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<entry dataset="Swiss-Prot" created="2021-02-10" modified="2025-04-09" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1U8QHS4</accession>
    <accession>C8VPE4</accession>
    <accession>Q5BCE4</accession>
    <name>SDGC_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FAD-dependent monooxygenase sdgC</fullName>
            <ecNumber evidence="4">1.-.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Aspernidgulenes biosynthesis cluster protein C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">sdgC</name>
        <name type="ORF">AN1786</name>
        <name type="ORF">ANIA_01786</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2019" name="ChemBioChem" volume="20" first="329" last="334">
            <title>Discovery and elucidation of the biosynthesis of aspernidgulenes: novel polyenes from Aspergillus nidulans by using serial promoter replacement.</title>
            <authorList>
                <person name="Lin T.S."/>
                <person name="Chen B."/>
                <person name="Chiang Y.M."/>
                <person name="Wang C.C.C."/>
            </authorList>
            <dbReference type="PubMed" id="30302871"/>
            <dbReference type="DOI" id="10.1002/cbic.201800486"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>PATHWAY</scope>
    </reference>
    <comment type="function">
        <text evidence="4">FAD-dependent monooxygenase; part of the gene cluster that mediates the biosynthesis of the polyenes aspernidgulenes (PubMed:30302871). The carbon backbone of aspernidgulenes is synthesized by the HR-PKS sdgA, which accepts acetyl-CoA as the starter unit and performs malonyl-CoA extensions as well as regioselective methylation and reduction (PubMed:30302871). The resulting nonaketide offloads the HR-PKS by intramolecular lactonization to yield the 5,6-dihydro-alpha-pyrone-containing hexaenoic acids preaspernidgulene A1 and A2 (PubMed:30302871). The FAD-dependent monooxygenase sdgC then installs the first epoxide on the penultimate double bond (PubMed:30302871). Subsequently, the FAD-dependent monooxygenase sdgF presumably generates a ketone intermediate through Meinwald rearrangement involving a hydride shift (PubMed:30302871). Next, sdgC introduces another epoxide on the last olefin of the ketone intermediate after E/Z isomerization (PubMed:30302871). The epoxide hydrolase sdgD then catalyzes stereospecific cyclization of the 5,6-dihydro-alpha-pyrone and opening of the epoxide ring to form an oxygenated trimethylcyclopentanone and an oxabicyclo[2.2.1]heptane unit (PubMed:30302871). Finally, the bicyclic unit undergoes hydrolytic cleavage, either spontaneously or catalyzed by sdgD, to assemble the dimethyl-gamma-lactone moiety in aspernidgulene A1 (PubMed:30302871).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="4"/>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF85559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AACD01000028">
        <property type="protein sequence ID" value="EAA63962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_659390.1">
        <property type="nucleotide sequence ID" value="XM_654298.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1U8QHS4"/>
    <dbReference type="SMR" id="A0A1U8QHS4"/>
    <dbReference type="STRING" id="227321.Q5BCE4"/>
    <dbReference type="GlyCosmos" id="A0A1U8QHS4">
        <property type="glycosylation" value="1 site, No reported glycans"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CBF85559">
        <property type="protein sequence ID" value="CBF85559"/>
        <property type="gene ID" value="ANIA_01786"/>
    </dbReference>
    <dbReference type="GeneID" id="2875010"/>
    <dbReference type="KEGG" id="ani:ANIA_01786"/>
    <dbReference type="eggNOG" id="KOG2614">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009665_12_2_1"/>
    <dbReference type="InParanoid" id="A0A1U8QHS4"/>
    <dbReference type="OMA" id="WAPWISK"/>
    <dbReference type="OrthoDB" id="10029326at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050562">
        <property type="entry name" value="FAD_mOase_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47356:SF2">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47356">
        <property type="entry name" value="FAD-DEPENDENT MONOOXYGENASE ASQG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0274">FAD</keyword>
    <keyword id="KW-0285">Flavoprotein</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0503">Monooxygenase</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000451915" description="FAD-dependent monooxygenase sdgC" evidence="2">
        <location>
            <begin position="24"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="446"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="330"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="B8M9J8"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="30302871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="5">
        <source>
            <dbReference type="PubMed" id="30302871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="6"/>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAA63962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005890"/>
        </source>
    </evidence>
    <sequence length="475" mass="52305" checksum="68F8DCD2F0BB4022" modified="2017-05-10" version="1" precursor="true">MDKRSFKVIVVGGSIAGLTLAHSLDLAGIDYIVLEKHSDPLATVGGSVGLLPNGWRILHQLGLRHQLEQEACPVKVAHMTYPDGFVFSDNFPAAIQERQVPEIQFPIGYMPANDERFGYSLSVLTRQQLIEVLYLGLRDKSKIKVGQRVIKIQHHQNRRGVSVFTESGQEHVGDLVAGADGVHSITRSQMWLQLGQKLDAEKERRQLVAEYSCVFGISSPLKGIPPGEQLIACHDNATVLAFPGKDAHIGWGLIQKLNRPCNSPATTQSSDGETALIMAKSAAGLGLCKDLKFHDLWVNTPKYSFTILEEGLFQIWHHGRIMTPNMAQGANTAIEGAAALANTLRRISQIDKPSEDDINRLLQGYTVRQQKRLRAVHAISRSVTRVHARQGRIKKIIGRYVYPYTPGAALHTFSRIIAPAPCLDYVPMPFPGPGWTRALVSGWSPISGVLLLVIPIIALVYGYSVINFGRDSINN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2025-10-08" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>C8V0H4</accession>
    <name>C8V0H4_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytochrome P450, putative (Eurofung)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ANIA_06414</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF69518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_664018.2">
        <property type="nucleotide sequence ID" value="XM_658926.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V0H4"/>
    <dbReference type="STRING" id="227321.C8V0H4"/>
    <dbReference type="GeneID" id="2871312"/>
    <dbReference type="KEGG" id="ani:ANIA_06414"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN6414"/>
    <dbReference type="eggNOG" id="KOG0156">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_14_2_1"/>
    <dbReference type="InParanoid" id="C8V0H4"/>
    <dbReference type="OMA" id="AHRCEIT"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11059">
        <property type="entry name" value="CYP_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000093">
        <property type="entry name" value="Cytochrome P450 monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF96">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE STCB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="6 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="4 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="451"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBF69518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="506" mass="56557" checksum="227855F34A4CCBC2" modified="2009-11-03" version="1">MIKSLPAAGTLSCLVRMMERSWKYIAIACALWVVQKIYSAITSPLRAIPGPFYTSLTRLPLKLSIIAGQRIYFIHSLHQRYGPIVRVSPTEVSIASLPEFREIHRVGSPFLKSNWYEKFVMGQHSPGVFAISDPKQHGARRRLFARAMSNTELRRVWEDVVRSKVRLAVDRIKGELEADGARCDVLKWWTFLATDVVGHLMFGEDFDMLNIGVKNEYIHVLESTMKGSGINAELPLVGCIGRHLPFSVVRSMFRANDYLTNYGKRAVTNARAKSDSSRNIFSGMLYEAEKCTDSDSGLSELDIITEAGNMIVAGSDTTAVTLTYLVWVVLSRPQLQREIESEVLALEEGYDDAKLETLPVLNAVIKETLRLYGAAPGSLPRTVPRGGATLGGYFIPEGMTVSTQSWTVHRDENLFPDPDSFNISRWLEENDAGFPAAQLAFSPFGAGGRICLGIHLAYMELRLAAAEFFRRCRGVRLSPDTTWKIMKPMNYFLIAPTGNRCDIMRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>C8V1J4</accession>
    <name>C8V1J4_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">arginyltransferase</fullName>
            <ecNumber evidence="2">2.3.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ANIA_06250</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the R-transferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.8" evidence="2"/>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF69856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050466955.1">
        <property type="nucleotide sequence ID" value="XM_050611520.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V1J4"/>
    <dbReference type="FunCoup" id="C8V1J4">
        <property type="interactions" value="599"/>
    </dbReference>
    <dbReference type="STRING" id="227321.C8V1J4"/>
    <dbReference type="GeneID" id="2871035"/>
    <dbReference type="KEGG" id="ani:ANIA_06250"/>
    <dbReference type="eggNOG" id="KOG1193">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020349_0_0_1"/>
    <dbReference type="InParanoid" id="C8V1J4"/>
    <dbReference type="OMA" id="KYQTAIH"/>
    <dbReference type="OrthoDB" id="74183at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004057">
        <property type="term" value="F:arginyl-tRNA--protein transferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010498">
        <property type="term" value="P:proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030700">
        <property type="entry name" value="N-end_Aminoacyl_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007472">
        <property type="entry name" value="N-end_Aminoacyl_Trfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007471">
        <property type="entry name" value="N-end_Aminoacyl_Trfase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21367">
        <property type="entry name" value="ARGININE-TRNA-PROTEIN TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21367:SF1">
        <property type="entry name" value="ARGINYL-TRNA--PROTEIN TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04377">
        <property type="entry name" value="ATE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04376">
        <property type="entry name" value="ATE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-end aminoacyl transferase N-terminal" evidence="5">
        <location>
            <begin position="24"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="N-end rule aminoacyl transferase C-terminal" evidence="6">
        <location>
            <begin position="175"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBF69856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="433" mass="49944" checksum="610A8969AFA80A97" modified="2009-11-03" version="1">MEPIDAERARQLSLFRPLGYQRNSCGYCKSDNGSASYYASSVSVRPVHYEELVNRGWRRSGTLYYKQNLQRSCCPHYTMRLEASAYKPRRDQRKAINRWNKFVLGPEYIRRAAYLCPKTREEKKHRKCNFDLHDAVHAVEYSNVKRPTDPKTKRSLEPAHRFEVNLEGDTVSQAKFDLFRKYQTKVHKEDVSKWQTKDFKRFLCSGLKRSEPNGRDVQRRIGSWHQCYRLDGKLIAVAVLDLMPNGVSSVYIFRSYDPDYEQWEIGKLSAMREIAFAVEQGYQYYYMGYYIHSCQKMRYKGNFRPQYILDGELTAKLNTRPYVSLSRDRATTATSGTEANAADNAEAEAEINDEEVSLFALHMPGVLTVDEVKKLDLGSWPLLIHGSFVHMSDLVGWEKMPIDEPQSIKGIVAELAATLGPTVMKDSAVVLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>C8V1V7</accession>
    <name>C8V1V7_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CNH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ANIA_10849</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the VAM6/VPS39 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF71321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_664324.2">
        <property type="nucleotide sequence ID" value="XM_659232.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V1V7"/>
    <dbReference type="STRING" id="227321.C8V1V7"/>
    <dbReference type="GeneID" id="2870343"/>
    <dbReference type="KEGG" id="ani:ANIA_10849"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN10849"/>
    <dbReference type="eggNOG" id="KOG2063">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004190_1_1_1"/>
    <dbReference type="InParanoid" id="C8V1V7"/>
    <dbReference type="OMA" id="EEYCNQV"/>
    <dbReference type="OrthoDB" id="5325112at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034058">
        <property type="term" value="P:endosomal vesicle fusion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007033">
        <property type="term" value="P:vacuole organization"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000547">
        <property type="entry name" value="Clathrin_H-chain/VPS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001180">
        <property type="entry name" value="CNH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032914">
        <property type="entry name" value="Vam6/VPS39/TRAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019452">
        <property type="entry name" value="VPS39/TGF_beta_rcpt-assoc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019453">
        <property type="entry name" value="VPS39/TGFA1_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12894">
        <property type="entry name" value="CNH DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12894:SF49">
        <property type="entry name" value="VAM6_VPS39-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00780">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10366">
        <property type="entry name" value="Vps39_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10367">
        <property type="entry name" value="zf-Vps39_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50236">
        <property type="entry name" value="CHCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50219">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CNH" evidence="6">
        <location>
            <begin position="18"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="4">
        <location>
            <begin position="745"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="53"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="478"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="81"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="484"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="538"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBF71321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="1124" mass="125406" checksum="8C95D6079B25A910" modified="2009-11-03" version="1">MLSAFTARPLVELKPRDKSRIEAVLAYGDRVLVGLNNGNLRVYRVNEVEIEAEHDADPPPTQNNGNGHDAGYGGSRPPTQNGNGDNGTNNPVAKAKRTDLLRELEKFSRYKIEQLAIIKEAKLLVSLSGGYVSIHDLQTYELQEQLTRTKGAVAFAVTSNIVNDPETGVPSIVSRLAVAVKRKIMLWSWRDMELENDTAELTLVSGIKTLTWVSGTRLVAGLSSNFVLVDIEMKTVTDLVGPGSIGGLGGQETGRLAGVGVASMSYIGIGGSAPKPLATRLSEGQILLAKDINTQFTDIDGNSLGRRQIPWSSAPADIGYSYPFLLALHDSMKGILEVRNPETLSLLQSISLPSASTMHIAQPTISLAHAGKGFLVASDRIIWRMEALGYDSQIDSLVEKGYLDEAISLAGMLEDALLKNKEGRIREIKLEKAEGMFRLRRYLESMELFTEVSAPPETVIQLYPRIIAGDLTSISEEDELEGSMTESQSKLPDSQAQAEGNGSEETTPIKALNHTPSMMSFLRSRDEGSGSDSGSVRGKPEEARLEKPLTGKDLKLAVRELQAYLADVRRRFQRFLNPDGSLKIDPQTHAAKDEYTDSVMKLLDVGEDDEDYDLGEKLREKARLVDTTLFRVYMYATPSLAGSLFRIANFCDPEVVMEKLEETGRHNDLIDFLYGKKMHRQALELLRKFGQSESEEETAPQLHGPKRMVAYLQHLPPEHIDLILEFSEWPIREDPDLGMEIFLADTENAETLPRQKVLDFLQGIDDKLAVRYLEHVIGELNDLTPDLHQRLAVLYLNRLQKHQNSKDGFATEDEYKFWREKLITMLKTSDQYSPSKILARLDRDDPEFFEARAILFSKMGQHRQALEIYVFKLEDYVKAEEYCNHLHRTEDTPTPSGPAAEYSALAPSDDEPSIYHTLLSLYLTPPHGYKPQYAPALDILARHGSRLPANSALDLIPESLPVHELEFYFKGRMRAANTILNESRITANLLKVQTIKTRAELLVGEGTDGRSSRSRHVTITEERVCSVCHKRIGGSVINVFPEAGLSFLIPRIVRLPKDSLFLLLRTPFTGLVYLLPCSSRRLMHRHQPLPLRSSLPPWLHSLTIGGPGLQLFSCPPPYVRSKTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>C8V2D0</accession>
    <name>C8V2D0_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ANIA_11501</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF70130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050466999.1">
        <property type="nucleotide sequence ID" value="XM_050611895.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V2D0"/>
    <dbReference type="STRING" id="227321.C8V2D0"/>
    <dbReference type="GeneID" id="74897077"/>
    <dbReference type="KEGG" id="ani:ANIA_11501"/>
    <dbReference type="HOGENOM" id="CLU_2372786_0_0_1"/>
    <dbReference type="InParanoid" id="C8V2D0"/>
    <dbReference type="OrthoDB" id="3552888at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF70130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="95" mass="10162" checksum="7FB1FD94190E4576" modified="2009-11-03" version="1">MRLATALPAFAAFTLERTSSSISPLTLPLNASNPSNLVPRNQPQSSTLALEAPIPGYGVEDFTWEMDTTPGGPTVLLNGIPAVNCILSKYVNRYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>C8V355</accession>
    <name>C8V355_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Rhamnosidase B, putative (AFU_orthologue AFUA_7G05040)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_10867</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF71752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467199.1">
        <property type="nucleotide sequence ID" value="XM_050611146.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V355"/>
    <dbReference type="GeneID" id="74896651"/>
    <dbReference type="KEGG" id="ani:ANIA_10867"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN10867"/>
    <dbReference type="eggNOG" id="ENOG502QVPG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009782_0_1_1"/>
    <dbReference type="InParanoid" id="C8V355"/>
    <dbReference type="OMA" id="NYPMAVK"/>
    <dbReference type="OrthoDB" id="6503935at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.420.10">
        <property type="entry name" value="Maltose phosphorylase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035396">
        <property type="entry name" value="Bac_rhamnosid6H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34987:SF2">
        <property type="entry name" value="B, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G05040)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34987">
        <property type="entry name" value="C, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G02880)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17389">
        <property type="entry name" value="Bac_rhamnosid6H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-L-rhamnosidase six-hairpin glycosidase" evidence="1">
        <location>
            <begin position="381"/>
            <end position="626"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF71752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="805" mass="91310" checksum="368A1B847706F1C7" modified="2009-11-03" version="1">MQQVTPNEQRIINTLQSNWIWVPNWIDSPPPNVNTAGRIVCFRRRLSLASPPTRALLHISADTRYKLFVNGERVAVGPTRSSPWIWYYDTIDIASYLRQGNNTVQLDVLRYFFVSRAAMPFQRTALPGLTVVGVIETENGAVELDTAKTEAWEARVDESRLFPMGLVDDPFLHINERVAPVELSAPITPILHGIKTLNGELAPWRLRPRAIPMYEESSVAVDTIRSCSSIRTKEEWLAGLSQSEKPLLLPAGSSHALDLQAAVHSTAFLRWTFKSTGRASSIRFKVTYSEGYELNPRAYPFFRTKNDRLDAENGHLIGPYDEIQLDIPAFGETIAYEPFWFRTFRFFRVEITVGSEPVALEALIARQVNYPLAIKANFANPSNPDSARIWDVSIRTMRNCMFDGYADCPFYEQLQYSGDSRSVGLFHYYLSGDDRLMRQAITNYAASITSEGLTQSRFPSHVPQIIAGFSLYWILQVADHFLFFGDRAYTRSFLPRIDGVLEFFESNVDQLGLVSGLPEDVWQYVDWVTTWGATDEHPDKGVPTSGRRSNRHTYFSLLYAYVLQRTAKLVRDLGRPGYAAEYEARAVSLQTAVRRHCYDGHYFTDSTADLSGDDAYSQHTQVFAILSGTALPDECSRLLKQSFADERFSRCSYMMRFYALRAFSAAGDEMYESFWRNEAWNPYRKMLAENLTTWEEDDVRQRSDCHAWGSVPIYEYCAELVGLTPVKPGCAKIRFKPRLRLSESVSAKVALGKDNLASVQWEAAGDQETRVHLKLESPVEVLSQLPGGEEVDHGAVDSLNLVWRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C8V415</accession>
    <name>C8V415_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Thioesterase-like superfamily-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_10534</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF74367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_661866.2">
        <property type="nucleotide sequence ID" value="XM_656774.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V415"/>
    <dbReference type="GeneID" id="2873685"/>
    <dbReference type="KEGG" id="ani:ANIA_10534"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN10534"/>
    <dbReference type="eggNOG" id="ENOG502S4FF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050730_0_0_1"/>
    <dbReference type="InParanoid" id="C8V415"/>
    <dbReference type="OMA" id="LVDMFPM"/>
    <dbReference type="OrthoDB" id="2532955at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.210">
        <property type="entry name" value="Acyl-CoA thioesterase, double hotdog domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049450">
        <property type="entry name" value="ACOT8-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042171">
        <property type="entry name" value="Acyl-CoA_hotdog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052389">
        <property type="entry name" value="Sec_Metab_Biosynth-Assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049449">
        <property type="entry name" value="TesB_ACOT8-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38110">
        <property type="entry name" value="CHROMOSOME 23, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38110:SF3">
        <property type="entry name" value="THIOESTERASE-LIKE SUPERFAMILY-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13622">
        <property type="entry name" value="4HBT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20789">
        <property type="entry name" value="4HBT_3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA thioesterase-like N-terminal HotDog" evidence="1">
        <location>
            <begin position="32"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA thioesterase-like C-terminal" evidence="2">
        <location>
            <begin position="185"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF74367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="343" mass="37682" checksum="8DFA35B03A2F5B7F" modified="2009-11-03" version="1">MDSGTAHGAQFEEAIRVTPLGHNRYSAFLQKSFCIGTVPHGGYTSAVLYRLALVHFATAHPNLYKGEPATPISMHLTFLRRTAEGPAKLRVHDMKLGKRTSSLHVELLQPKDQAQSGTEIDEREMEVKVAGYITVSPASSEVGVSAKTNWELHPKPVSGSRSDGGVDFDRLSKTGRDEAWARQDPPFAQFRKATTQVELYGIDPALKKRKNGIVDQWARLKPEGQLTRWSNEAVVFLTDMFPMALDGFDTMADGRESGSATGGAGPTAKYWFPTVSLSIDFKKRLPPAGEEWLYSRVVTKEVRDGRTDLDVTILDAKGEIVALSTQIGLVVSASRNIGKRARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C8V4F3</accession>
    <name>C8V4F3_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Golgi apparatus membrane protein TVP23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ANIA_03576</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Golgi membrane protein involved in vesicular trafficking.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Golgi apparatus membrane</location>
            <topology evidence="2 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the TVP23 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF75851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467528.1">
        <property type="nucleotide sequence ID" value="XM_050611503.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V4F3"/>
    <dbReference type="FunCoup" id="C8V4F3">
        <property type="interactions" value="375"/>
    </dbReference>
    <dbReference type="STRING" id="227321.C8V4F3"/>
    <dbReference type="GeneID" id="2872999"/>
    <dbReference type="KEGG" id="ani:ANIA_03576"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN3576"/>
    <dbReference type="eggNOG" id="KOG3195">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074845_1_1_1"/>
    <dbReference type="InParanoid" id="C8V4F3"/>
    <dbReference type="OMA" id="FEWMIVA"/>
    <dbReference type="OrthoDB" id="2151161at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008564">
        <property type="entry name" value="TVP23-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13019">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13019:SF7">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05832">
        <property type="entry name" value="DUF846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBF75851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="245" mass="27943" checksum="EB00499B00BFB27C" modified="2009-11-03" version="1">MEQQPLNSQPQQGDLNWRLSAHPITLLTFLGFRLGALLMYLFGVLFINNFILVFILTLLLLSADFYYLKNIAGRRLVGLRWWNEVNTTTGDSHWVFESADPNTRTIAATDKRFFWLSLYVAPALWIGLGILAIVRLNSVIWLSLIGTYTFSTQTQIRIRGGWKGADLFRVAIALVLTITNTTAFSRCDRFSQASTYANIIRVNVYWLFTPYGEDNHERLLNLPVVLSLTESPITFKPPVFCADEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C8V754</accession>
    <name>C8V754_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Disease resistance protein Aig2, putative (AFU_orthologue AFUA_5G03210)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_08193</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the gamma-glutamylcyclotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF74076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467275.1">
        <property type="nucleotide sequence ID" value="XM_050611227.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V754"/>
    <dbReference type="GeneID" id="3684056"/>
    <dbReference type="KEGG" id="ani:ANIA_08193"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN8193"/>
    <dbReference type="eggNOG" id="ENOG502S7T1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093936_1_0_1"/>
    <dbReference type="InParanoid" id="C8V754"/>
    <dbReference type="OMA" id="DPEPWQK"/>
    <dbReference type="OrthoDB" id="1044435at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="CDD" id="cd06661">
        <property type="entry name" value="GGCT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.10">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045038">
        <property type="entry name" value="AIG2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013024">
        <property type="entry name" value="GGCT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036568">
        <property type="entry name" value="GGCT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31544">
        <property type="entry name" value="AIG2-LIKE PROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31544:SF2">
        <property type="entry name" value="AIG2-LIKE PROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110857">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="45"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="54"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF74076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="224" mass="25160" checksum="9CB025B30F33FB78" modified="2009-11-03" version="1">MAPQILHRVIHGSPTPQQWQKDLLQFRPAVLHGYRRHRVRGADYPGIIRESESTQDAATDGSESATGKAALPSGPETRSRASVLGTVVSGLTDGDIHRLDIFEGAEYRREKVSVRILREALSKDLNNQDGVRNGDENRAHVDADAARDKHIKDVLEAAGADFADEEEEVETETYVWIAGRTMLEDAEWDFEAFKRDKMAWWVSADEKCVVSSHKKRSKTCKQSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>C8V7M7</accession>
    <name>C8V7M7_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">C6 transcription factor, putative (AFU_orthologue AFUA_4G12570)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ANIA_03684</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF75617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467490.1">
        <property type="nucleotide sequence ID" value="XM_050611461.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V7M7"/>
    <dbReference type="STRING" id="227321.C8V7M7"/>
    <dbReference type="GeneID" id="2873103"/>
    <dbReference type="KEGG" id="ani:ANIA_03684"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN3684"/>
    <dbReference type="eggNOG" id="ENOG502RSRA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019529_0_0_1"/>
    <dbReference type="InParanoid" id="C8V7M7"/>
    <dbReference type="OMA" id="FPCFSET"/>
    <dbReference type="OrthoDB" id="5319458at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.240.10:FF:000035">
        <property type="entry name" value="C6 transcription factor, putative (AFU_orthologue AFUA_4G12570)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052202">
        <property type="entry name" value="Yeast_MetPath_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782:SF2">
        <property type="entry name" value="TRANSCRIPTION FACTOR, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G12570)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="20"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="65"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBF75617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="624" mass="70377" checksum="43D3571B98550ABC" modified="2009-11-03" version="1">MSNSSFLDRPLLKVSRPVAACSRCRTAKIRCDGKLPACSACERAGKADTCSSSDEFPRGKERSYVGSLEAYCERLEKRAAELRERKRLLTGGEGGVVHENSITSASSVPATHAHSQEVSNIDDLVGEFGYLSVSATSRDFQGITSNTSFANLILAVSSGEQIPRSSPRPLPSRSEITPLIQHYFETFYVQLPFFLETSFWASVDSVYQNGAHFAKPFDNWAVRMVLAMAYGSLSNSQLDVNHRNALSLVQEALQYTEDVLRPGTLAGIQAILFLAQYSLIDPVHFRTWYLVGMAARVLVDLGLHQDHHAEYVLSSEKQDLRRRVFHCVYSLDRATSTALDRTLSFSDDSVNVAFPSSKLEKTYIFSHSSEPAWNMVKIRRILSAAYQQKYFTTTDPSFQSPTPTWVLYSQATEWFYNTPKNISQVLAIRYHLEFLYTITVILAPSTRHLPPCDYTKLLLFNRCIDYVHQLHQILESQIRLHVMDSIEIQRVYQTIRRLFNIVNQSFDVLMSPVPAAPQVPEDCPKPPSLELEDCLHCHERALECLNQAGNLLQYGARRWNHHALSQEFQKLSAPVRSILLPPAVTYAPTLGSYMPEEPAILPPADFLYGGLNLQHSSPENHNYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>C8V8A8</accession>
    <name>C8V8A8_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_11441</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF77335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467703.1">
        <property type="nucleotide sequence ID" value="XM_050611707.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V8A8"/>
    <dbReference type="GeneID" id="74897026"/>
    <dbReference type="KEGG" id="ani:ANIA_11441"/>
    <dbReference type="HOGENOM" id="CLU_2831183_0_0_1"/>
    <dbReference type="InParanoid" id="C8V8A8"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF77335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="66" mass="7151" checksum="218BF5040C20BFD4" modified="2009-11-03" version="1">MTEPGLSPLDASQNEPRTGSAKATISSHHSKLSKTAVVGWKYLVTGSDWWDKIDGVDALAIDRLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>C8V933</accession>
    <name>C8V933_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Meiotic sister chromatid recombination protein Ish1/Msc1, putative (AFU_orthologue AFUA_3G10480)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_04940</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF76433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467585.1">
        <property type="nucleotide sequence ID" value="XM_050611568.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V933"/>
    <dbReference type="FunCoup" id="C8V933">
        <property type="interactions" value="94"/>
    </dbReference>
    <dbReference type="STRING" id="227321.C8V933"/>
    <dbReference type="GeneID" id="2872737"/>
    <dbReference type="KEGG" id="ani:ANIA_04940"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN4940"/>
    <dbReference type="eggNOG" id="ENOG502RNIV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022672_1_0_1"/>
    <dbReference type="InParanoid" id="C8V933"/>
    <dbReference type="OMA" id="WTFDTWN"/>
    <dbReference type="OrthoDB" id="2527403at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018803">
        <property type="entry name" value="Ish1/Msc1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10281">
        <property type="entry name" value="Ish1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005669115" evidence="2">
        <location>
            <begin position="22"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="496"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF76433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="516" mass="57602" checksum="DBFABAE28DD869AF" modified="2009-11-03" version="1">MKLQLASWLVCALATAEAVGASNWFSKAVYNKWHETELERWLADHDIPYPSPADRKELENAVKTNWDLKVQKPLGQLSDHSGDRWEHTKEWIFDTWTDSQLKAFLDRHGIPSPQPRRRDTLLKAARENYEAVAKKLGEAAHYPGNWLYDQWSDSDLKLWLDERGWPAPQPTTRDRLIAAVRRNTRLASLQAKNIAASVVQSANAAQETLSEALFSAWSDSDLKRFLDEHGIHVPQGSKRNELIALARKHRAALVDQASSASSSVSSTASEYIGAATSRAGNEYARATDNASLKSQEAFDTAINSWSDSRLKAFLDARGVPVPQKNKRDELLAQVRLNKHKAATGWSAWTFDTWDTEHLKKYLSSVNSKVAHRAGVTRDELVKEAQDTYEKATKAGGSQLASATSYLKQATASAKDATFDTWSDSDLKQYLDSYGVPVYQGTELNELRAAARRNAHWFRYGTSTPQGALYAKFTGAAQWLLDQLKIGAASGRAQGREAAEKLQDKAEKKAEEVRSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C8VBC2</accession>
    <name>C8VBC2_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Integral membrane bound transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ANIA_10954</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF79400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467958.1">
        <property type="nucleotide sequence ID" value="XM_050611992.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VBC2"/>
    <dbReference type="STRING" id="227321.C8VBC2"/>
    <dbReference type="GeneID" id="2869477"/>
    <dbReference type="KEGG" id="ani:ANIA_10954"/>
    <dbReference type="eggNOG" id="KOG4711">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001127_0_0_1"/>
    <dbReference type="InParanoid" id="C8VBC2"/>
    <dbReference type="OMA" id="INEHFRH"/>
    <dbReference type="OrthoDB" id="68611at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052430">
        <property type="entry name" value="IVT-Associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049453">
        <property type="entry name" value="Memb_transporter_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47804">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47804:SF1">
        <property type="entry name" value="DUF2421 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13515">
        <property type="entry name" value="FUSC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="582"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="606"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="631"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="670"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="domain" description="Integral membrane bound transporter" evidence="7">
        <location>
            <begin position="552"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="287"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBF79400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="913" mass="102587" checksum="84F637BAA6F6A52D" modified="2009-11-03" version="1">MVATITVYFHPARSQGSMFKALVCACLAFIYTAFISITSMCVEMFFQDTLHLLPLGHAIVLIVFCGGGLGFIGWTKQRLNDPLVNVACSLASLSTISVLTKEGAVQAGDLSFTKISHVLKMIIMGVSATMTVSFLIFPISARKKLRSNLTSATETMATMLALITESFLSGSEEELQTAEFVNAAAQHKKAYGQLDSLVKEAKLEHYVRGTEKEYRLEKNLVRWVQDITHNLGGLRSAASMQFQLLKQTKPFGSPQPQSIGLSHQGVDVCRSISPWSMAEDRPYLEPIDERPEDDISEPDVLRPTLSRRQTSESEASAALLPADIFAIFIDHLGPSMRSLAFTLKEIFKEIPFGPAPSYKVTVDSRFITSLDRALELYKASREEALKSIYREKDIFKVKTLEIEADLEEVAASCGHFSFSLLEFGEQLKELLAILDELQLESEERPHGRSWNWLKFWRKNDLERRRFADSDQPLIESSPLRNSIAIPQPSYSSSQLQNSAPEFKKPFAKTRIGYQIWRSLSVFRRDDMKFAIKVGTGAALYACPSFITSTRPIYSHWRGEWGLLSYMLVCSMTIGASNTTGYARFLGTCLGAVCAILSWYITDGNALGLAFSGLMMATWTSYIIIVKRQGPMGRFIMLTYNLSVLYAYSLTQQDGQDDQDEGGDSPVITEIALHRVVAVFSGCIWGIIITRLIWPISARKRLKDGLALLWLRLSLIWKSGPLSATHSSKQQTEFMTARDKLEVERFLAHLESLQVSARSEFQLKQAFPDAVYTNLLAHTRNMVNAFVAMNLELAKNMTASQGELAILDYTVSERRHLSSRISHLLSFMASSMKMEYPLVDNLPNVEHARDRLLARLFHYRKNWEISKSSTDEDYSLLYAYVLVTGQLSKEIERISEEIGRLFGVLDESAVKLYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>C8VE53</accession>
    <name>C8VE53_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ANIA_11602</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF80380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468074.1">
        <property type="nucleotide sequence ID" value="XM_050612120.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VE53"/>
    <dbReference type="GeneID" id="74897163"/>
    <dbReference type="KEGG" id="ani:ANIA_11602"/>
    <dbReference type="HOGENOM" id="CLU_2606010_0_0_1"/>
    <dbReference type="InParanoid" id="C8VE53"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF80380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="79" mass="8610" checksum="7201ADD90FC753B3" modified="2009-11-03" version="1">MKANPMTPFSKTEPSMQNGTSIAGYVISSPQLESIPIDHAIPSLDQPELFRNVVKKNSAECLSGEQTHRTVKIAIKAQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>C8VER3</accession>
    <name>C8VER3_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cell wall cysteine-rich protein (AFU_orthologue AFUA_2G00400)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_08544</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF80768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468117.1">
        <property type="nucleotide sequence ID" value="XM_050612169.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VER3"/>
    <dbReference type="GeneID" id="2868881"/>
    <dbReference type="KEGG" id="ani:ANIA_08544"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN8544"/>
    <dbReference type="HOGENOM" id="CLU_930745_0_0_1"/>
    <dbReference type="InParanoid" id="C8VER3"/>
    <dbReference type="OMA" id="GEQCGVC"/>
    <dbReference type="OrthoDB" id="4492263at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002992175" evidence="1">
        <location>
            <begin position="19"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF80768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="291" mass="30840" checksum="3133DC9F8201915E" modified="2009-11-03" version="1">MVRISLLVLTASLATTLALPQNYCTAVCRPVKPECPAGEVATGSENCWGCCQPVSISANRVANATEMCTAVCRPEKPECPAGEAPTGQEGCWGCCAPITKTEEHICTRKCRLEKPECPAGEAPTGQEGCWGCCQPISKREERICTLECRLEKPECPAGEAPTGSEGCWGCCQPITASEKREGENDGDMCLAVCQEKKPECPAGEAPTGSEGCWGCCQPNAIAEKVAEGDSDVCMAVCQEKKPECPAGEAPTGQEGCWGCCTSVALVARQDQAHERPNDDHYWVTEDAGLAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>C8VEV5</accession>
    <name>C8VEV5_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Chromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ANIA_10632</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF80847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_662700.2">
        <property type="nucleotide sequence ID" value="XM_657608.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VEV5"/>
    <dbReference type="STRING" id="227321.C8VEV5"/>
    <dbReference type="GeneID" id="2871386"/>
    <dbReference type="KEGG" id="ani:ANIA_10632"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN10632"/>
    <dbReference type="eggNOG" id="KOG0017">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000384_6_12_1"/>
    <dbReference type="InParanoid" id="C8VEV5"/>
    <dbReference type="OMA" id="DEWEVNG"/>
    <dbReference type="OrthoDB" id="4509506at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF15">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="4">
        <location>
            <begin position="45"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="Chromo" evidence="3">
        <location>
            <begin position="283"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBF80847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="356" mass="40592" checksum="19448C4F9CD0406D" modified="2009-11-03" version="1">MLVSYEYFWPNISQDIRRFVQNCDICGRTKSWRDQRKGLLKPLPVPDHPWQEVSMDFITDLPESEGCTNIMVITDRLTKGVILEGMSEIDSESVAWALVRVLISKHGIPKAITSDRGSQFTRVSPFYLSHGYNLSPFSPTEEVEQLAEEPAKSPIQKGEAIVRKVKEALDWAQASMAYSQQNAENQANKHRSLATNYQVGDKVWLSLKNICTDRPSKKLDWKNAKYEVIGLVGSHAVRLNTPPGIYPVFHVDLLRLASSDLLPSQKNDDTQPPGIIVNGEKEYMVEKILDERPRRYGRGHRLEYLVKWSGYARPTWEAATALEEAQALDEWLDRTKQYRLQDGSLNRDAYIKAKAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>C8VH67</accession>
    <name>C8VH67_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">L-PSP endoribonuclease family protein (Hmf1), putative (AFU_orthologue AFUA_7G02340)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_09080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RutC family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF82591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_682349.2">
        <property type="nucleotide sequence ID" value="XM_677257.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VH67"/>
    <dbReference type="SMR" id="C8VH67"/>
    <dbReference type="FunCoup" id="C8VH67">
        <property type="interactions" value="540"/>
    </dbReference>
    <dbReference type="STRING" id="227321.C8VH67"/>
    <dbReference type="GeneID" id="2867961"/>
    <dbReference type="KEGG" id="ani:ANIA_09080"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN9080"/>
    <dbReference type="eggNOG" id="KOG2317">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100715_7_0_1"/>
    <dbReference type="InParanoid" id="C8VH67"/>
    <dbReference type="OMA" id="GSYFKEP"/>
    <dbReference type="OrthoDB" id="309640at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019239">
        <property type="term" value="F:deaminase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00448">
        <property type="entry name" value="YjgF_YER057c_UK114_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.40:FF:000001">
        <property type="entry name" value="L-PSP family endoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006056">
        <property type="entry name" value="RidA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019897">
        <property type="entry name" value="RidA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00004">
        <property type="entry name" value="Rid family detoxifying hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="2-IMINOBUTANOATE/2-IMINOPROPANOATE DEAMINASE RIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803:SF58">
        <property type="entry name" value="PROTEIN HMF1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01094">
        <property type="entry name" value="UPF0076"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF82591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="161" mass="17489" checksum="6A721081EC9260A8" modified="2009-11-03" version="1">MLRASFRLVTVSHSLLSPSIRPRISPRVRLPFQTAAMSDLTNIFTPNACPPVGPYSQAVKANGQIFLSGQIPADKNGNLVEGDIRTKTQACCDNIKAILDAAGSSVDKIIRVNVFLDDMSNFAEMNAQYEKFFTHKPARSCIAAKQLPKGVPVEIECIALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>C8VID9</accession>
    <name>C8VID9_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_10382</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF83259.1"/>
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    <dbReference type="OrthoDB" id="5394108at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="138"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF83259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="304" mass="33169" checksum="FCDB1124887AA8D4" modified="2009-11-03" version="1">MDLDYFCYSSDSEGEAEPSPQSELDHRSKTALRNIAQSERPASKKVRFEASPEDTPSKRRARATDPYRGRHFVGIGGPQTSSPPTTPTPEPHVVDPQQRPGFVPNKSGTFQLDYDALSDDSDTDTETVSSPKLPTPGTVRTSTPTQLDASLSAQSPAPRSAARSTQSPSTPAPKIDEEALARARSQAEKYKPKTPSGLRTASRYSSPLTAVTPDLTPVPAPPAEKDTEKFGDDEFAKDAQWLYSICPSGDLSQLVWPEKKPFGEGLIISSEALRIASEIWDPAEVDDAYDTFHREFAEFKKTAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C8VIS5</accession>
    <name>C8VIS5_EMENI</name>
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        <recommendedName>
            <fullName evidence="1">Tc1-like transposase DDE domain-containing protein</fullName>
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    <gene>
        <name evidence="2" type="ORF">ANIA_03048</name>
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        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
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            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
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        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF83503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_050612561.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VIS5"/>
    <dbReference type="STRING" id="227321.C8VIS5"/>
    <dbReference type="GeneID" id="2873923"/>
    <dbReference type="KEGG" id="ani:ANIA_03048"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN3048"/>
    <dbReference type="eggNOG" id="ENOG502SJME">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038496_0_0_1"/>
    <dbReference type="InParanoid" id="C8VIS5"/>
    <dbReference type="OMA" id="PIDIRHA"/>
    <dbReference type="OrthoDB" id="5415741at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
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        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052338">
        <property type="entry name" value="Transposase_5"/>
    </dbReference>
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        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
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        <property type="entry name" value="TC1-LIKE TRANSPOSASE DDE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TRANSPOSABLE ELEMENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tc1-like transposase DDE" evidence="1">
        <location>
            <begin position="265"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF83503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="390" mass="45127" checksum="6B9A4DBFB8202042" modified="2009-11-03" version="1">MMPRGGFHPVELRVQVLTLSAIGFSTEKISKSLNLSPRTVQSIVKKGRDRGYRPENTVITSVTADQAGREKLSEILAYEAGISHSSVLCILYSHGFVIAKPSWKPGLTEAACLRRLEFCLAHQHWTLEDWKRVIFTDETGVILGHRRGAIRVWRTVKDSHTRNCVRRRWKACSDFMVWGCFSYNKKGPLHIYKPETAAMWKQADIEIEAMNCELEPLCREEWELATGLSRVHLRPNRGRVPKWNWNEKNVLKPLLIPFAKECMIERPNTIVLEDSVPAHCHRIQQHVYKAEDVQKILDWPGNSPDLNAIEPCWAWMKKRTTSRGAPRDKKTGEAEWRQAWADLPQETIQHWIERLIRHIQIVIELEGGNEYKEGREDCDTRSWAGRRIKG</sequence>
</entry>
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    <accession>C8VL59</accession>
    <name>C8VL59_EMENI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_11320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
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            <taxon>Fungi</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF85949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VL59"/>
    <dbReference type="HOGENOM" id="CLU_3419422_0_0_1"/>
    <dbReference type="InParanoid" id="C8VL59"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF85949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="25" mass="2893" checksum="16694B718F616CC1" modified="2009-11-03" version="1">MDIDCNETTRRTNESEQTPPDALKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>C8VLB4</accession>
    <name>C8VLB4_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase LaeA-like, putative (AFU_orthologue AFUA_8G01930)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_08945</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF84602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468597.1">
        <property type="nucleotide sequence ID" value="XM_050612709.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VLB4"/>
    <dbReference type="STRING" id="227321.C8VLB4"/>
    <dbReference type="GeneID" id="2868197"/>
    <dbReference type="KEGG" id="ani:ANIA_08945"/>
    <dbReference type="eggNOG" id="ENOG502QSKG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010595_1_2_1"/>
    <dbReference type="InParanoid" id="C8VLB4"/>
    <dbReference type="OMA" id="LEGIVYM"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF31">
        <property type="entry name" value="LAEA-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G01930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF84602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="330" mass="38243" checksum="66E6E7F5362BA991" modified="2009-11-03" version="1">MADTEHGEFEPQQLIEPDTFDDQDSTYQSSLGDASYTTSITSSAMNYTYNGRRYHSYHEGEYVLPNDEQEQDRLDLSHHIYRMLLKGELHRAPVKNPARVLDIGTGTGIWAIDFADEHPETEVIGNDLSPIQPSWVPPNCRFEVDDFEQIWSYSQPFDFIHGRELEGAIRDHDHVFSEAFKSLKPGGWFEISSFDVNSYSDDGTHLRAKCMQEVVKNLHLSSKKFGKDMNTTHTWRERLEKAGFINVTEEMYKLPQSPWAKDPKMKELGRYHQVNMFEAIPPYCYALFTRVLGWQRPEIEALVAGIRQELKDMSLHLYTKVHVVYGQKPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>C8VN77</accession>
    <name>C8VN77_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Zn(II)2Cys6 transcription factor (Eurofung)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ANIA_01584</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF85162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_659188.2">
        <property type="nucleotide sequence ID" value="XM_654096.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VN77"/>
    <dbReference type="STRING" id="227321.C8VN77"/>
    <dbReference type="GeneID" id="2875229"/>
    <dbReference type="KEGG" id="ani:ANIA_01584"/>
    <dbReference type="eggNOG" id="ENOG502SHX6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009030_2_1_1"/>
    <dbReference type="InParanoid" id="C8VN77"/>
    <dbReference type="OMA" id="ERLACHH"/>
    <dbReference type="OrthoDB" id="3477330at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050675">
        <property type="entry name" value="OAF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069:SF32">
        <property type="entry name" value="ARGININE METABOLISM REGULATION PROTEIN II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069">
        <property type="entry name" value="OLEATE-ACTIVATED TRANSCRIPTION FACTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="24"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="142"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="245"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="165"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBF85162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="712" mass="78833" checksum="E4BB20612D98AD9D" modified="2009-11-03" version="1">MTELVWSLGGARKTKPSRSLSYTGCWTCRKRRIKCDETPVACRACQRAGLDCAGYDVRLIWNAGPNTRRRRIKPCALGCAPMTEAQVVRALETIEKSTTNSIGPFSVFTSQPPSAICSDTPEESQSLLPADEYVEDIFTDSMSHAHSTPPHSTDGSTADSNTDCQQAAAQSSSSSVEELPTHPLPDGTSGLPYRSTETSIPVDDIDSWDGTWIIPLEQTLTSRFSGALQFANRSLVADSREFRSHQPFVSSSPPPSDTHGILSTPGRVVSSSDLPRLEGNDRSPQGPVAGNRGVISLDCDLASTMIENTTATMLMDHYMQHVVHLMQPVSHPRNPFKTVYLPLALHGSSQLERSGRRSQLQSASIAAFHSLLSTAAANLQRMQGEQEALEQLACHHKQRSLIALQSALATKSTPYRDLMTAILSLVSADIMDGGMDDHWIHLEAGIKLLASRHYSLLVSRETSLLNNICKMLHLFGRTTRVHPERRAWPGYDHVPRGADFDTLEPSIEFIYGITTSIAGAIFRIYRLAQYLAYYREQGRPYPDSLLQSCETLGDELCSYTINSESFAEMDSTEAEPYMIDIARAQAKAFQGAARIYYYRSIQQCARSRLHREQQEVLAALNEAEDLKITFGKNGALPAPISWPAFVASCEAVGEQRRQWDGWWSRVLVYGMGNYSKQHATVHRVWSSLDADPDESMDWREALAAMGVRILPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>C8VTG0</accession>
    <name>C8VTG0_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein phosphatase PP1 regulatory subunit Sds22, putative (AFU_orthologue AFUA_1G04800)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ANIA_10088</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SDS22 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF89513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050469228.1">
        <property type="nucleotide sequence ID" value="XM_050613410.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VTG0"/>
    <dbReference type="STRING" id="227321.C8VTG0"/>
    <dbReference type="GeneID" id="74896194"/>
    <dbReference type="KEGG" id="ani:ANIA_10088"/>
    <dbReference type="eggNOG" id="KOG0531">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044236_0_0_1"/>
    <dbReference type="InParanoid" id="C8VTG0"/>
    <dbReference type="OMA" id="EVWASYN"/>
    <dbReference type="OrthoDB" id="266138at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072357">
        <property type="term" value="C:PTW/PP1 phosphatase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072542">
        <property type="term" value="F:protein phosphatase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045842">
        <property type="term" value="P:positive regulation of mitotic metaphase/anaphase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000055">
        <property type="entry name" value="Protein phosphatase 1 regulatory subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000446">
        <property type="entry name" value="Protein phosphatase 1 regulatory subunit SDS22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025875">
        <property type="entry name" value="Leu-rich_rpt_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050836">
        <property type="entry name" value="SDS22/Internalin_LRR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46652">
        <property type="entry name" value="LEUCINE-RICH REPEAT AND IQ DOMAIN-CONTAINING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46652:SF3">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12799">
        <property type="entry name" value="LRR_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="24"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBF89513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="355" mass="40627" checksum="DA4F6AF9B1598AA9" modified="2009-11-03" version="1">MKDSKGWDGKLRVEPKATITNPEALEDPDYSDSDAPPVEEIEADEDLLEDEDKDVEDIDLVHCRIHSILALRLERFTKLQRLCLRQNQISRIELPSSLGETLQELDLYDNLISHLKGLDDFHNLTSLDLSFNKLKHIKNISHLVKLKDLYFVQNKISKIEGLEGLTEIKNLELGANKIREIENLETLSALEELWLGKNKITEMKNLDALTNLRILSIQSNRLTSLKGLSSLKNLEELYVSHNAITDLAGLESNNALRVLDFSNNQVSKLEHLSHLKELEELWASNNQLSSFNEVERELKDKENLKTVYFEGNPLQTNGPVVYRNKVRLAIPQIMQIDASKCSTTRLYELLDQCCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>C8VTV7</accession>
    <name>C8VTV7_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA repair protein (Rad57), putative (AFU_orthologue AFUA_1G12520)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ANIA_10145</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
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    <dbReference type="VEuPathDB" id="FungiDB:AN10145"/>
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    <dbReference type="HOGENOM" id="CLU_013059_1_0_1"/>
    <dbReference type="InParanoid" id="C8VTV7"/>
    <dbReference type="OMA" id="GDGAYPE"/>
    <dbReference type="OrthoDB" id="1861185at2759"/>
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        <property type="entry name" value="P-loop_NTPase"/>
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        <property type="entry name" value="Rad51_C"/>
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        <property type="entry name" value="RecA_ATP-bd"/>
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        <property type="entry name" value="RE19845P"/>
        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR22942">
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    <dbReference type="Pfam" id="PF08423">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
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    <feature type="domain" description="RecA family profile 1" evidence="4">
        <location>
            <begin position="101"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="454"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="480"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50162"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="CBF88254.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="554" mass="60469" checksum="AA67F0E2DB434FD5" modified="2009-11-03" version="1">MDLLSILPEISIKSFSHILPPLERSRVNTVDLISLDTLEIAKRAHVPPADVRRLANHVIKALHNDVGFEEGPRPEQEQPDSSPDLELPLISGPRTKLDLSQWRTISTLDAALDTLLNGGIATGYVTEVTGESGSGKTQFLLGLLLAVQLPPPQGAGRSAIYISTEAPLATNRLSQLIECHPYLSTLSREQAPSLGRILSINAMDLESQDHILNYQLPVAIKRYNVGLVVIDSITSNYRAEHTSHDLSGLSTRSGELAKLGQMLRNLAASEDVAIVVANQVSDRFEGDAPLPFSRVTGDRTPMSSPATQQLRDYYVGFDREAAASPLSRVRTSEPANAELNHHTLAVSQCTPSFPSSSPLPTQDDQPQFDGSYLVGNPVRNEILSLQHQQRFFTGWGDSPPPLAHGTQPWVQQYTLKTPTLGLVWSTQIACRIALKKYNRPVIFDAVLDRNPTIPVQKLTSQEQDEPSESEVASDAASLPEENSTRPNNSTATAMKNVPTASAPQIIHSTEQSIQRTMKLVFAPWAGGSAPLSSEFGDEVEFEIWKGGIKAVKRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>C8VUP1</accession>
    <name>C8VUP1_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Auxin efflux transporter family protein (Eurofung)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ANIA_00930</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="CBF88504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_653442.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VUP1"/>
    <dbReference type="FunCoup" id="C8VUP1">
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    <dbReference type="STRING" id="227321.C8VUP1"/>
    <dbReference type="GeneID" id="2876703"/>
    <dbReference type="KEGG" id="ani:ANIA_00930"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN0930"/>
    <dbReference type="eggNOG" id="KOG2722">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026460_1_0_1"/>
    <dbReference type="InParanoid" id="C8VUP1"/>
    <dbReference type="OMA" id="WSWGYHI"/>
    <dbReference type="OrthoDB" id="2499604at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004776">
        <property type="entry name" value="Mem_transp_PIN-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31794">
        <property type="entry name" value="AUXIN EFFLUX TRANSPORTER FAMILY PROTEIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31794:SF2">
        <property type="entry name" value="AUXIN EFFLUX TRANSPORTER FAMILY PROTEIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03547">
        <property type="entry name" value="Mem_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="47"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="411"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="486"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="522"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="561"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="228"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="264"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBF88504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="584" mass="64526" checksum="843EEBC5261AAEE7" modified="2009-11-03" version="1">MAFFSSPRSFQNAQSLTSRQFVAQTQMGVNPGILQDISSPHSNHPPFLHLVLLVFEAVLEVVCVSLPGYIAARVGMFDADAQKFVANLNVALFTPCLIFTKLGSQLTAEKLTDLAIIPLIFIVQTAVSYSCAFVVSRCFRLKKRPSNFVAAMAVFGNSNSLPISLVISLSQTLNGLHWDRIPNDNDDEVAARGILYLLIFQQLGQLVRWSWGYRVLLAPKERYIEEGERDNGETVVAQGRERYTDNPEQVDPDEPLIRTRDSSDGSTEQATGSNDDSDVFHSGEATPVNTRSYSYTKLPHSGHEDQAHDQSPILGPPPSGPFLPRQDSRGDILYFPNVEVNPQDNTLEQGPLSRFKTSMGRLRVRIASGWARWTSALYSRLPPSLQKVLSKCSDSTSRFVRGVWDFMNPPLWAMLVAIIVASVPSLQRLFFDDGTFIPNSVTRAINQNGQVAVPLILVVLGANLERNTIPQEALEDTEDAETEKKLIIASLLARMLLPTIIMAPFLALIAKYAPVSIVDDPIFIIVCFLLTGAPSALQLAQICQINNTYVGAMSKLLFQSYVVWILPSTLILVMCALEVVEWAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-12-14" modified="2025-10-08" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>G5EB64</accession>
    <accession>C8V8E1</accession>
    <name>G5EB64_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histone deacetylase</fullName>
            <ecNumber evidence="2">3.5.1.98</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">ANIA_04493</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the histone deacetylase family. HD Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.98" evidence="2"/>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF77396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_662097.1">
        <property type="nucleotide sequence ID" value="XM_657005.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G5EB64"/>
    <dbReference type="SMR" id="G5EB64"/>
    <dbReference type="FunCoup" id="G5EB64">
        <property type="interactions" value="1017"/>
    </dbReference>
    <dbReference type="STRING" id="227321.G5EB64"/>
    <dbReference type="GeneID" id="2872294"/>
    <dbReference type="KEGG" id="ani:ANIA_04493"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN4493"/>
    <dbReference type="eggNOG" id="KOG1342">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007727_0_3_1"/>
    <dbReference type="InParanoid" id="G5EB64"/>
    <dbReference type="OMA" id="EHRWDKH"/>
    <dbReference type="OrthoDB" id="1918432at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033698">
        <property type="term" value="C:Rpd3L complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070210">
        <property type="term" value="C:Rpd3L-Expanded complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032221">
        <property type="term" value="C:Rpd3S complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004407">
        <property type="term" value="F:histone deacetylase activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141221">
        <property type="term" value="F:histone deacetylase activity, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd10004">
        <property type="entry name" value="RPD3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.20:FF:000001">
        <property type="entry name" value="Histone deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003084">
        <property type="entry name" value="HDAC_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF10">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01271">
        <property type="entry name" value="HISDACETLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="11">
        <location>
            <begin position="45"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="441"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="585"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="614"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="625"/>
            <end position="637"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00061569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CBF77396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="687" mass="75431" checksum="CFC7C65352366451" modified="2011-12-14" version="1">MASGTSGPAGPPLDPIDLNVSGDRSKRVAYFYDSDVGNYAYVSGHPMKPHRIRMTHSLVMNYSLYKKMEIYRAKPASKFEMTQFHTDEYIDFLSKVTPDNMDAFAKEQSKYNVGDDCPVFDGLFEFCGISAGGSMEGAARLNRNKCDIAVNWAGGLHHAKKSEASGFCYVNDIVLGILELLRFKQRVLYVDIDVHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGELRDIGVGQGKYYAVNFPLRDGIDDVSYKSIFEPVIKSVMEWYRPEAVVLQCGGDSLSGDRLGCFNLSMRGHANCVKYVKSFNLPTLIVGGGGYTMRNVARTWAFETGILVGDNLGSELPYNDYYEYFAPDYELDVRPSNMDNANTREYLDKIRTQVVENLKRTAFAPSVQMTDVPREPLVDGMDDEAEAALDDLDEDENKDKRFTKRRFDQYVEKPGELSDSEDEDENAANGVTRKPAHLKRRNQANYRLDLADSGVESGMATPQDASSVADEEMDTGTDVKITEAPGPEPDSEAQGTSSAAEPPSRAGNGSVDEPSEMIVDSKEPPRSVPVSRPVSPKPTDEDTAMEDADMPVPEVNQENTPEASQATQNKPAEGTPASESAVAKLTSQTKASFESNEGRKQLEPETVKEAGLAAVTTETKDKTPEAPRAGALPAVTAEQETTKQGEPSAEAQPEAAKE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-05-30" modified="2026-01-28" version="129" xmlns="https://uniprot.org/uniprot">
    <accession>O59922</accession>
    <accession>C8V8P0</accession>
    <accession>Q5B393</accession>
    <name>KAPR_EMENI</name>
    <protein>
        <recommendedName>
            <fullName>cAMP-dependent protein kinase regulatory subunit</fullName>
            <shortName>PKA regulatory subunit</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">pkaR</name>
        <name type="ORF">AN4987</name>
    </gene>
    <organism>
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="1998-01" db="EMBL/GenBank/DDBJ databases">
            <title>Characterization of the Aspergillus nidulans pkaR gene encoding the cAMP dependent protein kinase regulatory subunit.</title>
            <authorList>
                <person name="D'Enfert C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Tetramer, composed of 2 regulatory (R) and 2 catalytic (C) subunits. In the presence of cAMP it dissociates into 2 active monomeric C subunits and an R dimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cAMP-dependent kinase regulatory chain family.</text>
    </comment>
    <dbReference type="EMBL" id="AF043231">
        <property type="protein sequence ID" value="AAC18061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AACD01000084">
        <property type="protein sequence ID" value="EAA61065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF76336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_662591.1">
        <property type="nucleotide sequence ID" value="XM_657499.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O59922"/>
    <dbReference type="SMR" id="O59922"/>
    <dbReference type="FunCoup" id="O59922">
        <property type="interactions" value="420"/>
    </dbReference>
    <dbReference type="STRING" id="227321.O59922"/>
    <dbReference type="EnsemblFungi" id="CBF76336">
        <property type="protein sequence ID" value="CBF76336"/>
        <property type="gene ID" value="ANIA_04987"/>
    </dbReference>
    <dbReference type="KEGG" id="ani:ANIA_04987"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN4987"/>
    <dbReference type="eggNOG" id="KOG1113">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018310_0_0_1"/>
    <dbReference type="InParanoid" id="O59922"/>
    <dbReference type="OMA" id="WSPPHHP"/>
    <dbReference type="OrthoDB" id="417078at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
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    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030552">
        <property type="term" value="F:cAMP binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004862">
        <property type="term" value="F:cAMP-dependent protein kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034236">
        <property type="term" value="F:protein kinase A catalytic subunit binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000039">
        <property type="entry name" value="cAMP-dependent protein kinase regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000006">
        <property type="entry name" value="cAMP-dependent protein kinase type I-alpha regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050503">
        <property type="entry name" value="cAMP-dep_PK_reg_su-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012198">
        <property type="entry name" value="cAMP_dep_PK_reg_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11635">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE REGULATORY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11635:SF152">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000548">
        <property type="entry name" value="PK_regulatory"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00103">
        <property type="entry name" value="CAMPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00888">
        <property type="entry name" value="CNMP_BINDING_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00889">
        <property type="entry name" value="CNMP_BINDING_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0114">cAMP</keyword>
    <keyword id="KW-0116">cAMP-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <feature type="chain" id="PRO_0000205408" description="cAMP-dependent protein kinase regulatory subunit">
        <location>
            <begin position="1"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Dimerization and phosphorylation" evidence="2">
        <location>
            <begin position="23"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="16"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="49"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="binding site">
        <location>
            <begin position="160"/>
            <end position="291"/>
        </location>
        <ligand>
            <name>3',5'-cyclic AMP</name>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>3',5'-cyclic AMP</name>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>3',5'-cyclic AMP</name>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site">
        <location>
            <begin position="292"/>
            <end position="405"/>
        </location>
        <ligand>
            <name>3',5'-cyclic AMP</name>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="359"/>
        </location>
        <ligand>
            <name>3',5'-cyclic AMP</name>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="368"/>
        </location>
        <ligand>
            <name>3',5'-cyclic AMP</name>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="modified residue" description="Phosphoserine" evidence="1">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="412" mass="44904" checksum="40F574887A1D5CBB" modified="1998-08-01" version="1">MSNYSHSSNNPFLKVSTKEDKPSSFHKIAEDEEYEVTSPTDATFRASKNADNSAGGNNPLESGRAGESGDGIRFGRDPFGNFQGGAEGQDESSIDPNGFRPTGGPDHGFPNNYALGRRTSVSAESLNPTSAGSDSWTPPSHPKSEEQLARLKTAVSNNFLFSHLDDEQSRTVLDALVEKPIPAKDIKVISQGDAGDYFYIVEEGHFDVYINPSGSVQPGPDGAGTKISTIGPGGSFGELALMYNAPRAATIVSTEPKSTLWALDRITFRRILMDSAFQRRRMYEAFLEEVPLLSSLKPYERAKIADALDTIKFPAGEYIIKEGDPGDAFYLLESGEAEAFMEGVEEPVKSYKRGDYFGELALLDDKPRAASVRAKTEVKVAKLGRDGFKRLLGPVENIMRRTEYSSRPSTAT</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2026-01-28" version="144" xmlns="https://uniprot.org/uniprot">
    <accession>Q00177</accession>
    <accession>C8VPM8</accession>
    <accession>Q1HFU9</accession>
    <accession>Q5BCB2</accession>
    <name>XYNC_EMENI</name>
    <protein>
        <recommendedName>
            <fullName>Endo-1,4-beta-xylanase C</fullName>
            <shortName>Xylanase C</shortName>
            <ecNumber>3.2.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>1,4-beta-D-xylan xylanohydrolase C</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>34 kDa xylanase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Xylanase X34</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">xlnC</name>
        <name type="ORF">AN1818</name>
    </gene>
    <organism>
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1996" name="Gene" volume="175" first="29" last="33">
            <title>Identification, isolation and sequence of the Aspergillus nidulans xlnC gene encoding the 34-kDa xylanase.</title>
            <authorList>
                <person name="Maccabe A.P."/>
                <person name="Fernandez-Espinar M.-T."/>
                <person name="de Graaff L.H."/>
                <person name="Visser J."/>
                <person name="Ramon D."/>
            </authorList>
            <dbReference type="PubMed" id="8917072"/>
            <dbReference type="DOI" id="10.1016/0378-1119(96)00116-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <scope>FUNCTION</scope>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="11417" last="11422">
            <title>Development and application of a suite of polysaccharide-degrading enzymes for analyzing plant cell walls.</title>
            <authorList>
                <person name="Bauer S."/>
                <person name="Vasu P."/>
                <person name="Persson S."/>
                <person name="Mort A.J."/>
                <person name="Somerville C.R."/>
            </authorList>
            <dbReference type="PubMed" id="16844780"/>
            <dbReference type="DOI" id="10.1073/pnas.0604632103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA]</scope>
        <scope>FUNCTION</scope>
        <scope>BIOPHYSICOCHEMICAL PROPERTIES</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="613" last="613">
            <title>Elucidating how the saprophytic fungus Aspergillus nidulans uses the plant polyester suberin as carbon source.</title>
            <authorList>
                <person name="Martins I."/>
                <person name="Hartmann D.O."/>
                <person name="Alves P.C."/>
                <person name="Martins C."/>
                <person name="Garcia H."/>
                <person name="Leclercq C.C."/>
                <person name="Ferreira R."/>
                <person name="He J."/>
                <person name="Renaut J."/>
                <person name="Becker J.D."/>
                <person name="Silva Pereira C."/>
            </authorList>
            <dbReference type="PubMed" id="25043916"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-613"/>
        </citation>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2004" name="J. Biol. Chem." volume="279" first="36029" last="36037">
            <title>The dual nature of the wheat xylanase protein inhibitor XIP-I: structural basis for the inhibition of family 10 and family 11 xylanases.</title>
            <authorList>
                <person name="Payan F."/>
                <person name="Leone P."/>
                <person name="Porciero S."/>
                <person name="Furniss C."/>
                <person name="Tahir T."/>
                <person name="Williamson G."/>
                <person name="Durand A."/>
                <person name="Manzanares P."/>
                <person name="Gilbert H.J."/>
                <person name="Juge N."/>
                <person name="Roussel A."/>
            </authorList>
            <dbReference type="PubMed" id="15181003"/>
            <dbReference type="DOI" id="10.1074/jbc.M404225200"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) OF 25-327 IN COMPLEX WITH WHEAT XIP-1</scope>
        <scope>DISULFIDE BOND</scope>
    </reference>
    <comment type="function">
        <text evidence="4 6">Endo-1,4-beta-xylanase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose.</text>
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    <comment type="catalytic activity">
        <reaction>
            <text>Endohydrolysis of (1-&gt;4)-beta-D-xylosidic linkages in xylans.</text>
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        </reaction>
    </comment>
    <comment type="biophysicochemical properties">
        <phDependence>
            <text evidence="4">Optimum pH is 4.9.</text>
        </phDependence>
        <temperatureDependence>
            <text evidence="4">Optimum temperature is 52 degrees Celsius.</text>
        </temperatureDependence>
    </comment>
    <comment type="pathway">
        <text>Glycan degradation; xylan degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="6">Expressed in presence of xylan and repressed by glucose.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the glycosyl hydrolase 10 (cellulase F) family.</text>
    </comment>
    <comment type="sequence caution" evidence="7">
        <conflict type="erroneous gene model prediction">
            <sequence resource="EMBL-CDS" id="CBF85620" version="1"/>
        </conflict>
    </comment>
    <comment type="sequence caution" evidence="7">
        <conflict type="erroneous gene model prediction">
            <sequence resource="EMBL-CDS" id="EAA64983" version="1"/>
        </conflict>
    </comment>
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        <property type="protein sequence ID" value="CAA90075.1"/>
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        <property type="protein sequence ID" value="ABF50851.1"/>
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        <property type="entry name" value="JC5034"/>
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        <property type="nucleotide sequence ID" value="XM_654330.1"/>
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        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.70 A"/>
        <property type="chains" value="B=25-327"/>
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    <dbReference type="PDBsum" id="1TA3"/>
    <dbReference type="AlphaFoldDB" id="Q00177"/>
    <dbReference type="SMR" id="Q00177"/>
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        <property type="family name" value="Glycoside Hydrolase Family 10"/>
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    <dbReference type="KEGG" id="ani:ANIA_01818"/>
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        <property type="organism ID" value="517"/>
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        <property type="component" value="Chromosome VII"/>
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    <dbReference type="PANTHER" id="PTHR31490">
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        <property type="entry name" value="Glyco_hydro_10"/>
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        <property type="entry name" value="GLHYDRLASE10"/>
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        <property type="entry name" value="Glyco_10"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="GH10_2"/>
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    <proteinExistence type="evidence at protein level"/>
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    <keyword id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword id="KW-1015">Disulfide bond</keyword>
    <keyword id="KW-0326">Glycosidase</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0624">Polysaccharide degradation</keyword>
    <keyword id="KW-0873">Pyrrolidone carboxylic acid</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <keyword id="KW-0732">Signal</keyword>
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    <feature type="active site" description="Nucleophile" evidence="1">
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    <evidence type="ECO:0000250" key="1"/>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01096"/>
        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="104" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AQG3</accession>
    <accession>C8V5M1</accession>
    <name>Q5AQG3_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ANIA_09467</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the phosphatase 2A regulatory subunit B family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF73680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_868849.1">
        <property type="nucleotide sequence ID" value="XM_863756.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AQG3"/>
    <dbReference type="FunCoup" id="Q5AQG3">
        <property type="interactions" value="635"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5AQG3"/>
    <dbReference type="GeneID" id="3684064"/>
    <dbReference type="KEGG" id="ani:ANIA_09467"/>
    <dbReference type="eggNOG" id="KOG2085">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012437_1_2_1"/>
    <dbReference type="InParanoid" id="Q5AQG3"/>
    <dbReference type="OMA" id="ECSHEYT"/>
    <dbReference type="OrthoDB" id="10264446at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072542">
        <property type="term" value="F:protein phosphatase activator activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070199">
        <property type="term" value="P:establishment of protein localization to chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051177">
        <property type="term" value="P:meiotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051754">
        <property type="term" value="P:meiotic sister chromatid cohesion, centromeric"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031578">
        <property type="term" value="P:mitotic spindle orientation checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000786">
        <property type="term" value="P:positive regulation of autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031107">
        <property type="term" value="P:septin ring disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031134">
        <property type="term" value="P:sister chromatid biorientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000016">
        <property type="entry name" value="Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002554">
        <property type="entry name" value="PP2A_B56"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10257">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE 2A PP2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10257:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT GAMMA ISOFORM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01603">
        <property type="entry name" value="B56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028043">
        <property type="entry name" value="PP2A_B56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="605"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="612"/>
            <end position="625"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00064351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR028043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBF73680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="631" mass="72634" checksum="F85F77871F0F4F3D" modified="2005-04-26" version="1">MKGFRQRVHEQLSRAKDNKSSKKKESASQASQQNSANLGIHHGQQSASPNQVTPTSSTTSVNDIRGKAPEDASQAGGFPPATPTKQGQPMAPSVVISPSGPHAPPPGAAETMPGDLAPPRKSHVFDRLQTTPKDMSEGIRTPKRQHSSRFDISDQRQRELEKLPGFHEVPPNRRQELFMQKIDQCNIIFDFNDPTADMKSKEIKRLALHELLDYIANNRSVITEPMYPRVVEMFAKNLFRPIPPPITPQGEAFDPEEDEPVLEVAWPHIQVVYEFFLRFIESQDFNTNIAKAYIDHHFVLQLLELFDSEDPRERDFLKTTLHRIYGKFLNLRSYIRRSINNVFFQFSYETERFNGIAELLEILGSIINGFALPLKEEHKLFLTRVLLPLHKVKSLSMYHPQLAYCIVQFLEKDSTLTEDVVLGLLRYWPKTNSTKEVMFLNEVEDIFEVMDPAEFAKVQEPLFQQLAKSVASPHFQVAERALYFWNNEYFCNLVSDNVEVILPIMFPPLFENSKGHWNRTIHSMVYNAMKMFMEINPQLFDECSHEYNERQNSAEMREKARQNRWEKVAERAMQRQNGVNLPRNSTTAEIPLQLDDVDALTQESQRRLQSLKLDEAGSKDRRPREGSITSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="102" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ARW6</accession>
    <accession>C8VL90</accession>
    <name>Q5ARW6_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ANIA_08964</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF84557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_682233.1">
        <property type="nucleotide sequence ID" value="XM_677141.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ARW6"/>
    <dbReference type="GeneID" id="2868217"/>
    <dbReference type="KEGG" id="ani:ANIA_08964"/>
    <dbReference type="eggNOG" id="KOG1231">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018354_1_1_1"/>
    <dbReference type="InParanoid" id="Q5ARW6"/>
    <dbReference type="OMA" id="YWSLTAQ"/>
    <dbReference type="OrthoDB" id="2151789at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF53">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="5">
        <location>
            <begin position="40"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBF84557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="470" mass="51492" checksum="E1C8FEDF3AA1C335" modified="2005-04-26" version="1">MDTREKALANLHAAGLSDILYLPSSDVYSARVESYWSLTAQLKPWAIVRPRNTEEVSKAVKAIVATPDVKFAIRSGGHMQWPGANNIVNGITIDLGLMNSTTYDPETGIASIQPGGTWAKSYQELEKQGRMVAGGREGKVGIGGLLTGGGKTFYTCRNGFACDQVVNYELVLADGSISNANSTTNPDLFRALKGGGNNFGVVTRFDMTTFSAVDVWDCTITYPKKATLQLSEAIVDLTKNLAAYPDDHILAMWTYLPKTEEHFVMVNMMNLEGVKEARTLEKFLGIPEQMNRVDTTVSVATKLTSFVVPSGKYDTWYTTTFKADPQIILKSASVFESLVSALKNQVPYSNFYTQIVLQPLPVSFGAHSTARGGNMMGLDQMKVDCVLLVWAVEVDTPELNANVAGPTLKSAIEKIETYARSVKGDVGFRYLNYCDKEQDALGSYGEENVRHMKEVAVFSEKVAEDVVRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="111" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ARZ5</accession>
    <accession>C8VLH3</accession>
    <name>Q5ARZ5_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transketolase-like pyrimidine-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ANIA_08935</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the transketolase family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF84621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_682204.1">
        <property type="nucleotide sequence ID" value="XM_677112.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ARZ5"/>
    <dbReference type="STRING" id="227321.Q5ARZ5"/>
    <dbReference type="GeneID" id="2868146"/>
    <dbReference type="KEGG" id="ani:ANIA_08935"/>
    <dbReference type="eggNOG" id="KOG0523">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009227_0_0_1"/>
    <dbReference type="InParanoid" id="Q5ARZ5"/>
    <dbReference type="OMA" id="MTWCMVG"/>
    <dbReference type="OrthoDB" id="10267175at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004802">
        <property type="term" value="F:transketolase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd07033">
        <property type="entry name" value="TPP_PYR_DXS_TK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02012">
        <property type="entry name" value="TPP_TK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000004">
        <property type="entry name" value="Transketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.920:FF:000012">
        <property type="entry name" value="Transketolase, variant 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055152">
        <property type="entry name" value="Transketolase-like_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020826">
        <property type="entry name" value="Transketolase_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033247">
        <property type="entry name" value="Transketolase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43522">
        <property type="entry name" value="TRANSKETOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43522:SF6">
        <property type="entry name" value="TRANSKETOLASE-LIKE PYRIMIDINE-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22613">
        <property type="entry name" value="Transketolase_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00456">
        <property type="entry name" value="Transketolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00802">
        <property type="entry name" value="TRANSKETOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="9">
        <location>
            <begin position="375"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBF84621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="719" mass="78107" checksum="B232F8D6EEE7708F" modified="2005-04-26" version="1">MAPGLELLPKTTALPTKAANAINNAVYGRDSDVKFESAEKHQRVLNVFRAFIADLVQQYGDGHPGAPMGMAAIGIALWKYVMKYSPTNCNYFNRDRFVLSNGHACLWQYLFMHLVGVKSMTLEQLKSYHSTDSSSLCPGHPEIENEGVEVTTGPLGQGVANAVGLAMATKNLAATYNKPGYEVVNNMTWCMVGDACLQEGVGLEALSLAGHWRLNNLCVIFDNNNVTCDGTADVANTEDINTKMRATGFKVIDVYDGDSDVVAITNALLAARSSTKPTFINIRTTIGVGSKQAGTADAHGAALGVDEVAKIKRAFGLNPEEHFHIPQDVYDFFSDLPSRGKTHEAEWHAAVAAYREAEPVLASEFDLRVAGKMPADWTKYKLGQNVKNFLVGTADLTPSVNVAYKNKVDFQSPDLKTACGMSGNYAGRYIHYGIREHAMCAISNGLAAFNKGTFIPITSTYLVFHLYAAAAVRMAALQGLHQIHIATHDSIGVGENGPTHQPIAVPALYRAMPNILFIRPCDAEETVGAYIAAIQHDTTPSVLALSRQNLTQYPAHSSREGVQKGAYVFVEEENFDVTLLSVGSEMAYTMAAREILAAEHGIKARVVSFPCARLFELQSREYKHSVLKPRAGKPAVAIEAYPSVGWERYADAAIAQNQFGKSLPCKEVYEHFGFSGKIIADKVKGLVDEVRRDGVEVLRGDFRDLNGGPSVGVEHPNVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="133" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AS41</accession>
    <accession>C8VLT0</accession>
    <name>Q5AS41_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS sugar transporter, putative (AFU_orthologue AFUA_3G00220)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ANIA_08889</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF84724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_682158.1">
        <property type="nucleotide sequence ID" value="XM_677066.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AS41"/>
    <dbReference type="GeneID" id="2868215"/>
    <dbReference type="KEGG" id="ani:ANIA_08889"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_13_1"/>
    <dbReference type="InParanoid" id="Q5AS41"/>
    <dbReference type="OMA" id="EIAYPAH"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000134">
        <property type="entry name" value="MFS sugar transporter protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF3">
        <property type="entry name" value="HEXOSE TRANSPORTER PROTEIN (AFU_ORTHOLOGUE AFUA_8G04480)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="269"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="307"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="335"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="370"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="406"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="433"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="1"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="474"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="475"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBF84724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="501" mass="54816" checksum="842E9D9A91E4A74E" modified="2005-04-26" version="1">MTVRESQKPDNGQLAVVFETPWWSPQLRRLSFCILSLIFFSSSNGFDGSLVNGLQSLDSWMGFMGQPSGALVSTIFAAWCSNRYGRKQCVWIGIAFILAGSILGAAAPNDTVYIVSRAVIGVSSGMVSNAPPLLLNEIAYPAHRSISSCLFMIGYYFGAVISSWVTFATRTYASSWSWRLPTLLQMLCPLVAIPGFLLTPESPRWLIGQNRVEEARKVLADLHASGDLTAPLVIKEIHEIQEAISTERESAASSSYSDMITTPGNRHRLLITVTLGIFSQWSGNGVVSYYLAMVLDTVGVTATKDQLLISGCLQIWNLIFGTIGAVLVERAGRRPLFLTSAGVMLVSYIIITGLSGSFASTGSAPMGTAVIPFIFIYFAGYDIALTPLLVAYPCEIWPFALRSRGLSVAWFSAIGALIFNTFVNPIALSAIGWRYYFVFVAILICYGLTSWFVYPETKGYNLESISHIFDGNHQPGHDSEKATSSEDCIEKVPESREVERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="106" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AS52</accession>
    <accession>C8VLU4</accession>
    <name>Q5AS52_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyldiphosphate specific]</fullName>
            <ecNumber evidence="5">2.5.1.87</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">ANIA_08878</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>n isopentenyl diphosphate + (2E,6E)-farnesyl diphosphate = a di-trans,poly-cis-polyprenyl diphosphate + n diphosphate</text>
            <dbReference type="Rhea" id="RHEA:53008"/>
            <dbReference type="Rhea" id="RHEA-COMP:19494"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="ChEBI" id="CHEBI:136960"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
            <dbReference type="EC" id="2.5.1.87"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the UPP synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.87" evidence="5"/>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF84753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_682147.1">
        <property type="nucleotide sequence ID" value="XM_677055.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AS52"/>
    <dbReference type="FunCoup" id="Q5AS52">
        <property type="interactions" value="271"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5AS52"/>
    <dbReference type="GeneID" id="2868309"/>
    <dbReference type="KEGG" id="ani:ANIA_08878"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN8878"/>
    <dbReference type="eggNOG" id="KOG2818">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051870_1_0_1"/>
    <dbReference type="InParanoid" id="Q5AS52"/>
    <dbReference type="OMA" id="AWSSCAG"/>
    <dbReference type="OrthoDB" id="19639at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904423">
        <property type="term" value="C:dehydrodolichyl diphosphate synthase complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045547">
        <property type="term" value="F:ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1180.10">
        <property type="entry name" value="Decaprenyl diphosphate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038887">
        <property type="entry name" value="Nus1/NgBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036424">
        <property type="entry name" value="UPP_synth-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21528">
        <property type="entry name" value="DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE COMPLEX SUBUNIT NUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21528:SF0">
        <property type="entry name" value="DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE COMPLEX SUBUNIT NUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64005">
        <property type="entry name" value="Undecaprenyl diphosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CBF84753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="353" mass="39967" checksum="E18FCA86DA2EFF3D" modified="2005-04-26" version="1">MVSRRDRELLRDNIRSRGAKLSATDRENIMKPYLPDPSELPRWPPQRRRKLPRKTPIRTFIKSQIHLITYTFLHIFFGIAVRLVQTYHAVLDRILAIIYYHHRTPELIRKDVKDLDRLPGHLSVILSLRKEDDALPILMDEVAELVSWSASAGIPVLSVYEKSGLLKSCIPMLHQVITNKLSSYFGSLQQPTLQLFAPHHPIYKTRPAGDAAKNSLVVLLLSATDGQETLVDLTKTLAEMSQNGKLSPDDITMELVDAEISEITTQPSQDVAPTANDHKVSKPLQVKPEPDLLLVFGPSLKLNGYPPWHIRLTEMYCTGVNSDGFTGYGDNVEYQGFLRGLWHYAGAQMRFGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AS70</accession>
    <accession>C8V9B8</accession>
    <name>Q5AS70_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Adenylate kinase isoenzyme 6 homolog</fullName>
            <shortName evidence="10">AK6</shortName>
            <ecNumber evidence="10">2.7.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Dual activity adenylate kinase/ATPase</fullName>
            <shortName evidence="10">AK/ATPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ANIA_08860</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has also ATPase activity. Involved in the late cytoplasmic maturation steps of the 40S ribosomal particles, specifically 18S rRNA maturation. While NMP activity is not required for ribosome maturation, ATPase activity is. Associates transiently with small ribosomal subunit protein uS11. ATP hydrolysis breaks the interaction with uS11. May temporarily remove uS11 from the ribosome to enable a conformational change of the ribosomal RNA that is needed for the final maturation step of the small ribosomal subunit. Its NMP activity may have a role in nuclear energy homeostasis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>AMP + ATP = 2 ADP</text>
            <dbReference type="Rhea" id="RHEA:12973"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Interacts with small ribosomal subunit protein uS11. Not a structural component of 43S pre-ribosomes, but transiently interacts with them by binding to uS11.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the adenylate kinase family. AK6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.3" evidence="10"/>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF77857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_682129.1">
        <property type="nucleotide sequence ID" value="XM_677037.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AS70"/>
    <dbReference type="FunCoup" id="Q5AS70">
        <property type="interactions" value="795"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5AS70"/>
    <dbReference type="GeneID" id="2868405"/>
    <dbReference type="KEGG" id="ani:ANIA_08860"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN8860"/>
    <dbReference type="eggNOG" id="KOG3347">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079096_3_1_1"/>
    <dbReference type="InParanoid" id="Q5AS70"/>
    <dbReference type="OMA" id="QCEIFGT"/>
    <dbReference type="OrthoDB" id="10251185at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:AMP kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000372">
        <property type="entry name" value="Adenylate kinase isoenzyme 6 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00039">
        <property type="entry name" value="Adenylate_kinase_AK6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020618">
        <property type="entry name" value="Adenyl_kinase_AK6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12595:SF0">
        <property type="entry name" value="ADENYLATE KINASE ISOENZYME 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12595">
        <property type="entry name" value="POS9-ACTIVATING FACTOR FAP7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13238">
        <property type="entry name" value="AAA_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 10" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="NMPbind" evidence="10">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="LID" evidence="10">
        <location>
            <begin position="110"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CBF77857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="177" mass="20087" checksum="C264E4D7F2513908" modified="2005-04-26" version="1">MRTSPNIIITGTPGVGKTVHCEQLAQDTGLRHLSINQIAKDRDCIETYDEELKTWVVDEDKLLDAIEDEVLQGGYLIDWHACDLFPKSWIDLVVVLRCPSTSTLYDRLSSRGYHETKLQENLDAEIFGVLIEEAREGFDEEIVVELNSEEDGDVEANCARIASWIENWKSDQSKNSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="105" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ASD4</accession>
    <accession>C8V9P2</accession>
    <name>Q5ASD4_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GTP-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ANIA_08796</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">GTPase involved in activation of the TORC1 signaling pathway, which promotes growth and represses autophagy in nutrient-rich conditions.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the GSE complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the GTR/RAG GTP-binding protein family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF78003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_682065.1">
        <property type="nucleotide sequence ID" value="XM_676973.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ASD4"/>
    <dbReference type="FunCoup" id="Q5ASD4">
        <property type="interactions" value="261"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5ASD4"/>
    <dbReference type="GeneID" id="2868418"/>
    <dbReference type="KEGG" id="ani:ANIA_08796"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN8796"/>
    <dbReference type="eggNOG" id="KOG3886">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044099_0_0_1"/>
    <dbReference type="InParanoid" id="Q5ASD4"/>
    <dbReference type="OMA" id="LIPNMQD"/>
    <dbReference type="OrthoDB" id="10020193at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990131">
        <property type="term" value="C:Gtr1-Gtr2 GTPase complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010507">
        <property type="term" value="P:negative regulation of autophagy"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd11384">
        <property type="entry name" value="RagA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.190:FF:000003">
        <property type="entry name" value="Small monomeric GTPase (Gtr1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000488">
        <property type="entry name" value="Small monomeric GTPase (Gtr1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006762">
        <property type="entry name" value="Gtr1_RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039397">
        <property type="entry name" value="RagA/B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11259">
        <property type="entry name" value="RAS-RELATED GTP BINDING RAG/GTR YEAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11259:SF1">
        <property type="entry name" value="RAS-RELATED GTP-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04670">
        <property type="entry name" value="Gtr1_RagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBF78003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="332" mass="37394" checksum="342755F052709544" modified="2005-04-26" version="1">MDGRKKKRKVLLMGKSGSGKSSMRSIIFSNYVAKDVRRLGATIDVEHSHVKFMGNLTLNLWDCGGQDAFMETYLASQRGNIFSDVAVLIYVFDIESREVERDLDTYMAIIAALREYSPHAYVFCLVHKLDLIQAEHRQRIYEERSALIRSRTEHFTIDTFGSSIWDQSLYKAWAGIVHKLIPNLSVIERFLHAFAKRIDAEEVILFERSTFLTVTSVSSEIGDLNPIYDRHERLSNIMKAFKHCAARNTHTTPASAGFVVMHTKTPQFNVFLGRFTDNTYIFIVVPPGEAAYNCAVLNTMLAREGFSKAAGAVHGDGFPLPAPDSPDESNSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ASE6</accession>
    <accession>C8V9Q4</accession>
    <name>Q5ASE6_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_08784</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
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            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF78026.1"/>
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        <property type="nucleotide sequence ID" value="XM_676961.1"/>
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    <dbReference type="AlphaFoldDB" id="Q5ASE6"/>
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    <dbReference type="KEGG" id="ani:ANIA_08784"/>
    <dbReference type="eggNOG" id="ENOG502S7FQ">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_084831_2_0_1"/>
    <dbReference type="InParanoid" id="Q5ASE6"/>
    <dbReference type="OrthoDB" id="2253354at2759"/>
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        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035213">
        <property type="entry name" value="DUF5321"/>
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        <property type="match status" value="1"/>
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        <location>
            <begin position="10"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="172"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF78026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="247" mass="27962" checksum="3D72D44D7591FC25" modified="2005-04-26" version="1">MNSTRLFLRVRPSATSKTTTPTALLSPAHPRRTPSTHFQACSYGTRLTTEHLPKIAQPSLWTSLIPKSFRNRSPSTSPASSPKTKEWNPASFYIIIFILIGSQAIRMIALKNEYNSYLRSTDAKIRLLKEVIGKIQRGEEVDVEKMLGTGDARVEREWDEVLKEIEREDSLWHQKQKRAAEDKAKEEARQRTARRNERPASFSQLFPASSQTCSPPEQRDCGGMGTAMARADRKLAEWDSSAQSSLR</sequence>
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    <accession>Q5ASI1</accession>
    <accession>C8V9Z2</accession>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
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            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF78103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_676926.1"/>
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    <dbReference type="AlphaFoldDB" id="Q5ASI1"/>
    <dbReference type="GeneID" id="2868442"/>
    <dbReference type="KEGG" id="ani:ANIA_08749"/>
    <dbReference type="eggNOG" id="ENOG502RC91">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_024469_1_1_1"/>
    <dbReference type="InParanoid" id="Q5ASI1"/>
    <dbReference type="OMA" id="KEPYFAR"/>
    <dbReference type="OrthoDB" id="2150604at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
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    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
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        <property type="entry name" value="Alcohol_O-acetyltransferase"/>
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        <property type="entry name" value="CAT-like_dom_sf"/>
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    <dbReference type="PANTHER" id="PTHR28037">
        <property type="entry name" value="ALCOHOL O-ACETYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR28037:SF1">
        <property type="entry name" value="ALCOHOL O-ACETYLTRANSFERASE 1-RELATED"/>
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        <property type="entry name" value="CoA-dependent acyltransferases"/>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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    </evidence>
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    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
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                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S58 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF78337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_681877.1">
        <property type="nucleotide sequence ID" value="XM_676785.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ASX2"/>
    <dbReference type="GeneID" id="2868481"/>
    <dbReference type="KEGG" id="ani:ANIA_08608"/>
    <dbReference type="eggNOG" id="ENOG502QRNQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1468146_0_0_1"/>
    <dbReference type="InParanoid" id="Q5ASX2"/>
    <dbReference type="OMA" id="CYAASHD"/>
    <dbReference type="OrthoDB" id="2107894at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.70.12">
        <property type="entry name" value="L-amino peptidase D-ALA esterase/amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016117">
        <property type="entry name" value="ArgJ-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005321">
        <property type="entry name" value="Peptidase_S58_DmpA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36512:SF3">
        <property type="entry name" value="BLR5678 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36512">
        <property type="entry name" value="D-AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03576">
        <property type="entry name" value="Peptidase_S58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56266">
        <property type="entry name" value="DmpA/ArgJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="173"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF78337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="184" mass="20259" checksum="EF8CF781FEE3358A" modified="2005-04-26" version="1">MVGTRPRIRDLGYSPGRFRPGPKNSLLDVKGVTVGQITIHKDPDVHTGLTLIFPRGMHGTRQHPCYAASHDLNGMGELRDRMGLQSGALTNTVSIGKVYDALFSFQFEQADALCEEDIESARRMTIPVVGETFDGLLNDIRRSVIDNTTVYRAIEAAETQPEILEGNHGGLNMGQQLHNTQESN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ASX8</accession>
    <accession>C8VAG9</accession>
    <name>Q5ASX8_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ANIA_08602</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF78352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_681871.1">
        <property type="nucleotide sequence ID" value="XM_676779.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ASX8"/>
    <dbReference type="GeneID" id="2868478"/>
    <dbReference type="KEGG" id="ani:ANIA_08602"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN8602"/>
    <dbReference type="eggNOG" id="ENOG502STGI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041681_0_0_1"/>
    <dbReference type="InParanoid" id="Q5ASX8"/>
    <dbReference type="OMA" id="RDDYMPF"/>
    <dbReference type="OrthoDB" id="3944128at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF78352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="437" mass="47631" checksum="7068CD832980C20F" modified="2005-04-26" version="1">MLLLALWIGAAIAQDAITSDQWLITLNTSIFWPTSTDYFYGPTTGPSASAVTCNAAWVEYARRSTELRSLGPTATSPSLVSYMTSEGACRTSVSPEAWSNTHSGPLTTLCDGAPRALGPREIVTAYYPGTGPCASSYITNTYTETFYREPSVTPDCTLETTDCVSIWQTYSSISSSWRDSVVTPTPGDTNSPIPPFDCPTPARTYPEENPCSNCHFLPGTATLFYWPVTTAAGDLCLQNGTTVPASGPSTAIVNGETFISPTVYLSFTSIYAWSNRRAHPGSQCGVDHSNTIVSLHPSTLTSMRNHRNAKYPIIGTAYPFNFAEFMPHEIGNYTQSLIPWPQYRGGQQCPIPDGNTCTMIRDDYMPWLMIPEEVRDIDPGWSVCDNDWYIPPVTMVALDKPEITITPAPEASEFRLDAAAAPKEGLAATTPEPTRGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ASY1</accession>
    <accession>C8VAH3</accession>
    <name>Q5ASY1_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ANIA_08599</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF78360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_681868.1">
        <property type="nucleotide sequence ID" value="XM_676776.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ASY1"/>
    <dbReference type="GeneID" id="2868494"/>
    <dbReference type="KEGG" id="ani:ANIA_08599"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN8599"/>
    <dbReference type="eggNOG" id="ENOG502QVG4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053011_0_0_1"/>
    <dbReference type="InParanoid" id="Q5ASY1"/>
    <dbReference type="OMA" id="RPRFMAQ"/>
    <dbReference type="OrthoDB" id="4664297at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF78360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="331" mass="37894" checksum="C07031E12D711E36" modified="2005-04-26" version="1">MATETHPSVQPESVSQYALTESQKAHFLQHGYVVIPDCFSREKALSWTKDVWIRLGYSPTDKSTWTSERINMPHHREEAVRTFAPKAWAAICELCGGEDRISEEFGSWRDSLIVNLGLPEYEGMKNPDPKELDNWHVDGDFFWHFLDSPEQALLVIPLFSDIAPMGGATMICPEAIPLMARYLYEHPEGVSPYMVPRGEVQSQNPDAEPGLSFYTNLVQKCTDFREMTGKTGDVVLMHPLMLHSASRNILRTPRIITNPPVALKEPFNFDRDDPSKYSLVEKKTLLALGKDRLKGWKITTERERIVPARLKRFHEMKIKEEERLRQAEVGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="117" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AU36</accession>
    <accession>C8V757</accession>
    <name>Q5AU36_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Endosomal cargo receptor (Erp3), putative (AFU_orthologue AFUA_5G03260)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">ANIA_08194</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endomembrane system</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF74081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_681463.1">
        <property type="nucleotide sequence ID" value="XM_676371.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AU36"/>
    <dbReference type="FunCoup" id="Q5AU36">
        <property type="interactions" value="56"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5AU36"/>
    <dbReference type="GeneID" id="2868988"/>
    <dbReference type="KEGG" id="ani:ANIA_08194"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN8194"/>
    <dbReference type="eggNOG" id="KOG1693">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066963_4_2_1"/>
    <dbReference type="InParanoid" id="Q5AU36"/>
    <dbReference type="OMA" id="VGEYTFC"/>
    <dbReference type="OrthoDB" id="1929172at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006621">
        <property type="term" value="P:protein retention in ER lumen"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036598">
        <property type="entry name" value="GOLD_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101576">
        <property type="entry name" value="Supernatant protein factor (SPF), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010292097" evidence="10">
        <location>
            <begin position="21"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="176"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="11">
        <location>
            <begin position="32"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CBF74081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="210" mass="23943" checksum="FDA2CA3634520453" modified="2005-04-26" version="1">MRFTALLIGLLAYLVSSVTATALTYRLEANEKACFYKFVEQRNTKVAFYFAVQSGGSFDVDYAVVGPGEKPVLDGTKERQGDFVFTAQSVGEYRFCFNNEMSTFAEKMVDFEIALENESRTELPSRQGANPEQASAIEESIFKLSAQLSTISRNQKYFRTRENRNFSTVRSTERRIWNFSIIESLMMVSMAGLQVFIVRFFFQGARKGYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AU65</accession>
    <accession>C8V6X8</accession>
    <name>Q5AU65_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_08165</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF74019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_676342.1"/>
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    <dbReference type="AlphaFoldDB" id="Q5AU65"/>
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    <dbReference type="HOGENOM" id="CLU_016581_1_0_1"/>
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        <property type="component" value="Chromosome II"/>
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        <property type="entry name" value="Methyltranfer_dom"/>
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    <dbReference type="InterPro" id="IPR052220">
        <property type="entry name" value="METTL25"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12496">
        <property type="entry name" value="CGI-41 METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12496:SF0">
        <property type="entry name" value="METHYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
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            <begin position="147"/>
            <end position="401"/>
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    </feature>
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        <location>
            <begin position="242"/>
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        </location>
    </feature>
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        <location>
            <begin position="242"/>
            <end position="260"/>
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    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF74019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="635" mass="71619" checksum="1228945BD1D788C6" modified="2005-04-26" version="1">MSATRSLPLPEGWTDPDAYVEALLSFATSSDLFRHLCGGVHMLDFLTREPDLYTTLLPEDWRQFFEHHNIADIIDLLLRDDIQPMLAAYKQGDLAGQEWRGVAVLPPLSLIEFIQQIRRLTLRREFTPHGSGKATIPPRIAVGMKVKKYHEVAHFSKYVNSLCDTVHRERGEEITHIVDFGSGQNYLGRTLASPPYNRNIVAIERRHQFINGANRMDVYAKLAEKKKVRLYNKKLDKCKTCEDPDMPVEKLDSQPERTSDDVDEQDTGNDDEGVAEISIFRDISVTSDELGTFPKAGGTVQKPVTNTNTDAPRGAMNYIEHEIKDGYLEPIIKDVVAPSSQKSAEPTDDVENTEQASDVNVMVVSLHSCGNLVHHGVRALVLNPSVKAIAMIGCCYNLMTERLGPATYKLPVLRTMHPRLSKDATAYDPHGFPMSRRLEEFKHDGGTGVKLNITARSMAVQAPYNWGTADAEDFFTRHYYRTLLQRVLVDRGVVPKPSVPKDLYSTEPEKLEDVGNPLIVGSLRKAAFTSFQAYVRAAVVKLSRDPVYGQKIKENMVTITDEELDRYATEYWPTKKRLSVTWTLMSFCAAVAEAIIAVDRWQFLREQDCVKECWVEPVFDYGQSPRNLAVIGIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="108" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AUB5</accession>
    <accession>C8V6M6</accession>
    <name>Q5AUB5_EMENI</name>
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        <recommendedName>
            <fullName evidence="6">Nucleoside phosphorylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ANIA_08115</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF73917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_681384.1">
        <property type="nucleotide sequence ID" value="XM_676292.1"/>
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    <dbReference type="AlphaFoldDB" id="Q5AUB5"/>
    <dbReference type="STRING" id="227321.Q5AUB5"/>
    <dbReference type="GeneID" id="2868925"/>
    <dbReference type="KEGG" id="ani:ANIA_08115"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN8115"/>
    <dbReference type="eggNOG" id="ENOG502T4FU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_34_22_1"/>
    <dbReference type="InParanoid" id="Q5AUB5"/>
    <dbReference type="OMA" id="CIEMESA"/>
    <dbReference type="OrthoDB" id="1577640at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
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    </dbReference>
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        <property type="entry name" value="NLR-like"/>
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        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
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        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
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        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
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        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="RPA2825-like"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="12"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3597" evidence="3">
        <location>
            <begin position="319"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="307"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="307"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBF73917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="419" mass="45400" checksum="6E92286DC7013635" modified="2005-04-26" version="1">MSSKRLRVEDYRVACITVIPAEYAAFEQMFDHTHGQPIGIDRGDLNHYEYGDVAGHNVVLCAAARPGTNNAAITATEVRRTFHNLKFGLLVGIGGGVPNGSCDIRLGDVVVAASDGTSNGITHHDHGKQLSDAFILLNYPVVTPRVLEGVICAVRASDILDASAIPQIISAVTKKYPKFQRPDNEHDLLFKAAYEHIAGNFDCDECAKEQLEDRAPRESLVPHVHYGPIASGNQVVKSAEKREFLRQSYGVYCIEMEAAGVMPTLPSLVIRGISDYADSHKNDRWQNYAALAAAAYAKDLLTRISPSDSTSGRDVSSSGTAGQPASTVARNPKLEDLLEHRGRQIGAKDWRSSIVDLLKVLGLKSDGASRNDLAAILQVREGLSGSAKRNNALRRALMDCLVVEDGDVVSPNSLDALRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AUJ4</accession>
    <accession>C8V600</accession>
    <name>Q5AUJ4_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aldo-keto reductase (AKR), putative (AFU_orthologue AFUA_5G01910)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ANIA_08036</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF73751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_681305.1">
        <property type="nucleotide sequence ID" value="XM_676213.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AUJ4"/>
    <dbReference type="GeneID" id="2869099"/>
    <dbReference type="KEGG" id="ani:ANIA_08036"/>
    <dbReference type="eggNOG" id="KOG1577">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_10_1_1"/>
    <dbReference type="InParanoid" id="Q5AUJ4"/>
    <dbReference type="OMA" id="FQSFWTL"/>
    <dbReference type="OrthoDB" id="5357513at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004032">
        <property type="term" value="F:aldose reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000045">
        <property type="entry name" value="Aldo-keto reductase (AKR), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF3">
        <property type="entry name" value="NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="4">
        <location>
            <begin position="29"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBF73751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="299" mass="33659" checksum="6B2E16F326418F29" modified="2005-04-26" version="1">MSWEGYTLRSLQHANPAFVPTFLYGTAWKKDRTGDLVHQAISTGFRAVDTAAQPKHYREDLVGEGIRKVLSDGIVRREDLYNPDDMPYNPNNSLTDQVHSSVRSSFYNLRPSAEPESAEETYIDTLVLHSPLPTMAQTIEAWSALETYVPHRIRHLGISNTTLSVLRELVSLAKVKPAVVQNRFYAGTQFDVPLRAYCREHEILYQSFWTLTANPELVRSRPVIALARDAGISSVAALYGLVLGLGQTTILNGTTKKEHMEADLNALKSLALFSNENPEEWQNILEDFEQLTGDHVYLQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-04-05" modified="2025-04-09" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AUR8</accession>
    <accession>C8V5D9</accession>
    <name>NPIIA_EMENI</name>
    <protein>
        <recommendedName>
            <fullName>Neutral protease 2 homolog AN7962</fullName>
            <ecNumber>3.4.24.39</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Deuterolysin AN7962</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="ORF">AN7962</name>
    </gene>
    <organism>
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="613" last="613">
            <title>Elucidating how the saprophytic fungus Aspergillus nidulans uses the plant polyester suberin as carbon source.</title>
            <authorList>
                <person name="Martins I."/>
                <person name="Hartmann D.O."/>
                <person name="Alves P.C."/>
                <person name="Martins C."/>
                <person name="Garcia H."/>
                <person name="Leclercq C.C."/>
                <person name="Ferreira R."/>
                <person name="He J."/>
                <person name="Renaut J."/>
                <person name="Becker J.D."/>
                <person name="Silva Pereira C."/>
            </authorList>
            <dbReference type="PubMed" id="25043916"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-613"/>
        </citation>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Secreted metalloproteinase that allows assimilation of proteinaceous substrates. Shows high activities on basic nuclear substrates such as histone and protamine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>Preferential cleavage of bonds with hydrophobic residues in P1'. Also 3-Asn-|-Gln-4 and 8-Gly-|-Ser-9 bonds in insulin B chain.</text>
            <dbReference type="EC" id="3.4.24.39"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peptidase M35 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.39"/>
    <dbReference type="EMBL" id="AACD01000135">
        <property type="protein sequence ID" value="EAA59616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF73605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_681231.1">
        <property type="nucleotide sequence ID" value="XM_676139.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AUR8"/>
    <dbReference type="SMR" id="Q5AUR8"/>
    <dbReference type="STRING" id="227321.Q5AUR8"/>
    <dbReference type="MEROPS" id="M35.002"/>
    <dbReference type="EnsemblFungi" id="CBF73605">
        <property type="protein sequence ID" value="CBF73605"/>
        <property type="gene ID" value="ANIA_07962"/>
    </dbReference>
    <dbReference type="KEGG" id="ani:ANIA_07962"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN7962"/>
    <dbReference type="eggNOG" id="ENOG502SGF5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039313_1_1_1"/>
    <dbReference type="InParanoid" id="Q5AUR8"/>
    <dbReference type="OMA" id="ANCDLYY"/>
    <dbReference type="OrthoDB" id="412874at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11008">
        <property type="entry name" value="M35_deuterolysin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050414">
        <property type="entry name" value="Fungal_M35_metalloproteases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001384">
        <property type="entry name" value="Peptidase_M35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37016">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37016:SF3">
        <property type="entry name" value="NEUTRAL PROTEASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02102">
        <property type="entry name" value="Peptidase_M35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00768">
        <property type="entry name" value="DEUTEROLYSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00142">
        <property type="entry name" value="ZINC_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword id="KW-1015">Disulfide bond</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0482">Metalloprotease</keyword>
    <keyword id="KW-0645">Protease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <keyword id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="propeptide" id="PRO_0000407102" evidence="1">
        <location>
            <begin position="20"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000407103" description="Neutral protease 2 homolog AN7962">
        <location>
            <begin position="179"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="306"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="320"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="184"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="262"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="25043916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <sequence length="354" mass="37423" checksum="129ECC9B8FE79605" modified="2005-04-26" version="1" precursor="true">MKFIAPIALLGMFQAASASPVDIKTSNAGLQVTLSQINNTRIKAVVQNTGSEEVTFMHMNFFKDASPVKKVSIFRNNDEVEFQGIKYRVQTDDLSDEVLTSLAPGASFEDEFDIAATSDLSSGGPVTIRSEGIVPLVTEKSVTGSLSYSSNELTIDVDGAEAAKIETVGAQLSKLSKRTRVSSCSGTRATALQTALRNAASLASRAASAASQGGSTFTTFFKSDSSSTRNAVAARLRAVASESSSTSSGSTTYYCTDVYGYCSSNVLAYTLPAYNIIANCDIYYTYLPALTGTCYAQDQATTTLHEFTHAPGVYSPGTDDLGYGYDAATRLSASQALNNADSYALYANAVYLGC</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2010-06-15" modified="2026-01-28" version="103" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AV15</accession>
    <accession>C8V7D6</accession>
    <name>BGLJ_EMENI</name>
    <protein>
        <recommendedName>
            <fullName>Probable beta-glucosidase J</fullName>
            <ecNumber>3.2.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Beta-D-glucoside glucohydrolase J</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Cellobiase J</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Gentiobiase J</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">bglJ</name>
        <name type="ORF">AN7865</name>
    </gene>
    <organism>
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Beta-glucosidases are one of a number of cellulolytic enzymes involved in the degradation of cellulosic biomass. Catalyzes the last step releasing glucose from the inhibitory cellobiose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text>Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21"/>
    <dbReference type="EMBL" id="AACD01000134">
        <property type="protein sequence ID" value="EAA58910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF73413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_681134.1">
        <property type="nucleotide sequence ID" value="XM_676042.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AV15"/>
    <dbReference type="SMR" id="Q5AV15"/>
    <dbReference type="STRING" id="227321.Q5AV15"/>
    <dbReference type="CAZy" id="GH3">
        <property type="family name" value="Glycoside Hydrolase Family 3"/>
    </dbReference>
    <dbReference type="GlyCosmos" id="Q5AV15">
        <property type="glycosylation" value="3 sites, No reported glycans"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CBF73413">
        <property type="protein sequence ID" value="CBF73413"/>
        <property type="gene ID" value="ANIA_07865"/>
    </dbReference>
    <dbReference type="KEGG" id="ani:ANIA_07865"/>
    <dbReference type="eggNOG" id="ENOG502QR4D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004542_4_0_1"/>
    <dbReference type="InParanoid" id="Q5AV15"/>
    <dbReference type="OMA" id="SQGCYGH"/>
    <dbReference type="OrthoDB" id="47059at2759"/>
    <dbReference type="UniPathway" id="UPA00696"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.300:FF:000006">
        <property type="entry name" value="Beta-glucosidase H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000119">
        <property type="entry name" value="Probable beta-glucosidase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019800">
        <property type="entry name" value="Glyco_hydro_3_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037524">
        <property type="entry name" value="PA14/GLEYA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011658">
        <property type="entry name" value="PA14_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF16">
        <property type="entry name" value="BETA-GLUCOSIDASE J-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07691">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00758">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00775">
        <property type="entry name" value="GLYCOSYL_HYDROL_F3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51820">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword id="KW-0136">Cellulose degradation</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0326">Glycosidase</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0624">Polysaccharide degradation</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <feature type="chain" id="PRO_0000394894" description="Probable beta-glucosidase J">
        <location>
            <begin position="1"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="domain" description="PA14" evidence="3">
        <location>
            <begin position="423"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="254"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="43"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="850" mass="92696" checksum="D960EA3EBBFA8555" modified="2005-04-26" version="1">MYRQEATTVTILAQAPPNWPAPAFDISGFTSAFRPSRRAQRSNTTMGSIDTNSTDAWHTFAIPRLGIPAMRITDGPNGARGTRYFNGVPSACLPCGTALGATFDTDLLFKLGRLLAAECKAKGAHVLLGPTINIQRGPLGGRGFESFSEDPVLSGNSAASYCAGVKDLGIVPTLKHLVCNDQEHERIAVSAMVTERALREIYLMPFQLAIKNARPGALMTSYNKVNGLHASEDPGLLNHIIRKEWGFEGLIMSDWFGTYSVASAVNAGLDLEMPGPTRFRGPALMHALTSNKVSEKTLDDRVRKVLELVQLTSRAGIPEYAPAQKLDRVEDRVLLRQAAADSIVLLKNANEVLPLDPRKKTLVIGPNADIAAYCGGGSASLLAYYTVTPRQGIAEKCEEVVFSQGCYGHKELPLLGDHLKTETGERGYTFRVYTEPATYEDRQPVDVLHMTNSCAFLMDYSHPKISGDTYYATLEGRFEPTESGVYELGLTVAGTGLLYIDGELVIDNKTKQRHGTSFFGIGTVEERGERYLEAGRQHHVFVEYSTAPTSNLKHHGVVSFGPGGVRLGGCRKLDAETAIKQAVQLAAETEQVVVCVGMNGNWESEGFDRPHMDLPPGTDNLVRAVIEAQPNAVIVVQSGTPVTMPWADQAKALVQAWYGGSEGGNGIADVLFGDVNPSAKLPLTFPRDIAHNPSYLSYRSERGRVLYSEDVYVGYRYYDKVKQAPLFHFGHGLSYTTFKLSGLNVQETDPQASDISAEVVQIYVRPPTTASVGRPVRELKGYEKTMLHPGETKEISVTVPMGVATSFWDEGRSAWLSEKGTYAIEVVGTGERNMLSAPLCVQVSRYWNGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="121" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AVF9</accession>
    <accession>C8VDI5</accession>
    <name>Q5AVF9_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Translocon Sec61/SecY plug domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">ANIA_07721</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the SecY/SEC61-alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF79973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_680990.1">
        <property type="nucleotide sequence ID" value="XM_675898.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AVF9"/>
    <dbReference type="FunCoup" id="Q5AVF9">
        <property type="interactions" value="905"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5AVF9"/>
    <dbReference type="GeneID" id="2869747"/>
    <dbReference type="KEGG" id="ani:ANIA_07721"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN7721"/>
    <dbReference type="eggNOG" id="KOG1373">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031763_2_1_1"/>
    <dbReference type="InParanoid" id="Q5AVF9"/>
    <dbReference type="OMA" id="PMMRQMF"/>
    <dbReference type="OrthoDB" id="420669at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005784">
        <property type="term" value="C:Sec61 translocon complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904680">
        <property type="term" value="F:peptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015450">
        <property type="term" value="F:protein-transporting ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005048">
        <property type="term" value="F:signal sequence binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070843">
        <property type="term" value="P:misfolded protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031204">
        <property type="term" value="P:post-translational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030970">
        <property type="term" value="P:retrograde protein transport, ER to cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006616">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3370.10:FF:000002">
        <property type="entry name" value="Transport Sec61 subunit alpha isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3370.10">
        <property type="entry name" value="SecY subunit domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002208">
        <property type="entry name" value="SecY/SEC61-alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030659">
        <property type="entry name" value="SecY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023201">
        <property type="entry name" value="SecY_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019561">
        <property type="entry name" value="Translocon_Sec61/SecY_plug_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00967">
        <property type="entry name" value="3a0501s007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006341">
        <property type="entry name" value="PRK08568.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10906">
        <property type="entry name" value="SECY/SEC61-ALPHA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10559">
        <property type="entry name" value="Plug_translocon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00344">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004557">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103491">
        <property type="entry name" value="Preprotein translocase SecY subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00755">
        <property type="entry name" value="SECY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00756">
        <property type="entry name" value="SECY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 10 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="75"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="284"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="359"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="416"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="440"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="Translocon Sec61/SecY plug" evidence="13">
        <location>
            <begin position="41"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF10559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CBF79973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="478" mass="52216" checksum="D5C4D192209211CC" modified="2005-04-26" version="1">MSGLRFLDLIKPFTPLLPEVAAPETKVPFNQKLMWTGLTLLIFLVMSQMPLYGIVSSDTSDPLYWLRMMLASNRGTLMELGITPIISSGMVFQLLAGTHLIDVNLDLKTDRELYQTAQKLFAIILSFGQACVYVLTGLYGQPSDLGAGICVLLIVQLVVAGLVVILLDELLQKGYGLGSGISLFIATNICESIVWKAFSPTTINTGRGPEFEGAIIALFHLLFTWSDKQRALREAFYRQNLPNVMNLLATLVVFAAVIYLQGFRVEIPVKSSRQRGMRGSYPVRLFYTSNMPIMLQSALCSNIFLISQMLYSRFSDNILVKLLGVWEPREGSAQLHASSGVAYYMSPPLNFREALLDPIHTAVYITFMLVACALFSKTWIEVSGSAPRDVAKQLKDQGLVMAGHREQSMYRELKRIIPTAAAFGGACIGALSVASDLLGALGSGTGILLAVTIIYGYFEIAAREGDIGGGLKGLVPGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AVX2</accession>
    <accession>C8VBP4</accession>
    <name>Q5AVX2_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_07558</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF79627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_680827.1">
        <property type="nucleotide sequence ID" value="XM_675735.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AVX2"/>
    <dbReference type="GeneID" id="2869603"/>
    <dbReference type="KEGG" id="ani:ANIA_07558"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN7558"/>
    <dbReference type="eggNOG" id="ENOG502RNIK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1348662_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AVX2"/>
    <dbReference type="OMA" id="TTEPGRH"/>
    <dbReference type="OrthoDB" id="4509376at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="52"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF79627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="197" mass="21184" checksum="BDD6A75D49430FDB" modified="2005-04-26" version="1">MSTTNQPPQPPKQSSYTQPSNPVTQNPAESQQTEQRSHTYGTAPATITRGTSSNPSNPSNVSSTRTKKEQSGKSLHAHGDVDTEYGVEQQPSEGDIANAVEGRSRHRAQAGAHAGPVGTAQGPGMPARGEGVSNLQDLDRKAEEHQRILGDKVGRSPPIEGEEVEREKLRERKLRQDRKLHTSDAVSEATGKPVVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AW15</accession>
    <accession>C8VBK1</accession>
    <name>Q5AW15_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aspergillopepsin, putative (AFU_orthologue AFUA_3G02970)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ANIA_07515</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF79544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_680784.1">
        <property type="nucleotide sequence ID" value="XM_675692.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AW15"/>
    <dbReference type="STRING" id="227321.Q5AW15"/>
    <dbReference type="MEROPS" id="G01.004"/>
    <dbReference type="GeneID" id="2869578"/>
    <dbReference type="KEGG" id="ani:ANIA_07515"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN7515"/>
    <dbReference type="eggNOG" id="ENOG502RJF6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066466_0_1_1"/>
    <dbReference type="InParanoid" id="Q5AW15"/>
    <dbReference type="OMA" id="SLNWAGY"/>
    <dbReference type="OrthoDB" id="2862635at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004175">
        <property type="term" value="F:endopeptidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070007">
        <property type="term" value="F:glutamic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd13426">
        <property type="entry name" value="Peptidase_G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.700">
        <property type="entry name" value="Peptidase G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000250">
        <property type="entry name" value="Peptidase_G1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038656">
        <property type="entry name" value="Peptidase_G1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37536">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_3G02970)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37536:SF3">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_3G02970)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01828">
        <property type="entry name" value="Peptidase_A4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00977">
        <property type="entry name" value="SCYTLDPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010168534" evidence="3">
        <location>
            <begin position="20"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="207"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="103"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="115"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600250-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR600250-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBF79544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="270" mass="28308" checksum="5BDCB647464F6291" modified="2005-04-26" version="1">MKLSIAAISSILLAGGALAAPLTEARRQARALRGRGPSNRASHPPYKVGSTELLSLSNETQVEYSSNWAGAVLIGTGYTSVTGEFTVPTPSLPTGASRNKQYCASAWVGIDGDTCSTAILQTGIDFCIQGSSVSFDAWYEWYPDYAYDFSGITISAGDSIRVTVDATTLTAGTATVENLTTGKTVTHTFTGGVDGDLCEYNAEWIVEDFESNGQLVPFADFGTVTFTSAEVTNDGKTVGPSGATIIDIKQGNSVLTDVSVTDDSVTVSYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="129" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AW42</accession>
    <accession>C8VBG5</accession>
    <name>Q5AW42_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">agmatinase</fullName>
            <ecNumber evidence="5">3.5.3.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ANIA_07488</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>agmatine + H2O = urea + putrescine</text>
            <dbReference type="Rhea" id="RHEA:13929"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:58145"/>
            <dbReference type="ChEBI" id="CHEBI:326268"/>
            <dbReference type="EC" id="3.5.3.11"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the arginase family. Agmatinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.3.11" evidence="5"/>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF79478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_680757.1">
        <property type="nucleotide sequence ID" value="XM_675665.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AW42"/>
    <dbReference type="STRING" id="227321.Q5AW42"/>
    <dbReference type="GeneID" id="2869675"/>
    <dbReference type="KEGG" id="ani:ANIA_07488"/>
    <dbReference type="eggNOG" id="KOG2964">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039478_1_1_1"/>
    <dbReference type="InParanoid" id="Q5AW42"/>
    <dbReference type="OMA" id="YELTTIM"/>
    <dbReference type="OrthoDB" id="288726at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008783">
        <property type="term" value="F:agmatinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033389">
        <property type="term" value="P:putrescine biosynthetic process from arginine, via agmatine"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019627">
        <property type="term" value="P:urea metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11592">
        <property type="entry name" value="Agmatinase_PAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.10:FF:000006">
        <property type="entry name" value="Agmatinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.10">
        <property type="entry name" value="Ureohydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006035">
        <property type="entry name" value="Ureohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020855">
        <property type="entry name" value="Ureohydrolase_Mn_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358">
        <property type="entry name" value="ARGINASE/AGMATINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358:SF26">
        <property type="entry name" value="GUANIDINO ACID HYDROLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00491">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00116">
        <property type="entry name" value="ARGINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01053">
        <property type="entry name" value="ARGINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51409">
        <property type="entry name" value="ARGINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010248546" description="agmatinase" evidence="8">
        <location>
            <begin position="20"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="405"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="411"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00050304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00066392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBF79478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="430" mass="46776" checksum="0038078C52142B00" modified="2005-04-26" version="1">MKLTWAGLWALAGTALCCSHHDEESVPQEVREELLKKWNQEWSFSGHASFAHLKPVKCLVEPDEKYDIAIIGAPFDTAVSYRPAGARFGPRAIRAASARQMAGTSYNTRAGINPYSSWATIKDCGDIPITPFDNGLAERQMYEAFLELGTRSPVTPASSEYGSKGISAGKSKLVTLGGDHSVALPALRALYQIYQKPITVLHFDAHLDTWNPVRYSAYWQSEQSAFNHGSFFHKASREGLICNSTSAHAGLRTRLTGIDDSDYTAPGTPEQGFMRIHADDIDELGGPMGVVNKIMERIGLDLDQPVYLSVDIDVLDPSTAPGTGTPEPGGWTTREFIRILRGIEKLNIVGADIVEVSPSYDNKGETTALAAAQVAYEIITSMVKNGAGKDLGGWYGRKESVTQESVPVVDAEAEVEAEVPEPESVLKDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AWH8</accession>
    <accession>C8VCJ9</accession>
    <name>Q5AWH8_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GDP/GTP exchange factor Sec2 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ANIA_07352</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF78563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_680621.1">
        <property type="nucleotide sequence ID" value="XM_675529.2"/>
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    <dbReference type="AlphaFoldDB" id="Q5AWH8"/>
    <dbReference type="STRING" id="227321.Q5AWH8"/>
    <dbReference type="GeneID" id="2869774"/>
    <dbReference type="KEGG" id="ani:ANIA_07352"/>
    <dbReference type="eggNOG" id="ENOG502S1Y5">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_055310_1_0_1"/>
    <dbReference type="InParanoid" id="Q5AWH8"/>
    <dbReference type="OMA" id="CADYEDQ"/>
    <dbReference type="OrthoDB" id="5560525at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
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    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0000318"/>
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    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
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    <dbReference type="Gene3D" id="6.10.140.910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040351">
        <property type="entry name" value="RAB3IL/RAB3IP/Sec2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009449">
        <property type="entry name" value="Sec2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14430:SF4">
        <property type="entry name" value="GDP_GTP EXCHANGE FACTOR SEC2 N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14430">
        <property type="entry name" value="RABIN3-RELATED"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF06428">
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        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF144284">
        <property type="entry name" value="Sec2 N-terminal region"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="190"/>
            <end position="267"/>
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    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="27"/>
            <end position="46"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="79"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="198"/>
            <end position="275"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="27"/>
            <end position="37"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="80"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="99"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBF78563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="280" mass="30978" checksum="2536C0BD2D80591F" modified="2005-04-26" version="1">MATTTATAYTSTTLVSVPSTFGTNCPTCGQAPGSQSHPAEPTRRRVKELEGQVQFLNEQAAKMSEKLLEYEAELRRLRAQSPNQGQNQPSSFTSRNGFSISSTSTSSHSPSNSQSQSPLQVQQTQSRLSSLASLLPYRRPSTASSQPQSQSQPPASPGAQQCQLAPFTQSPPPLSQPRTDTPTPRPSFEETLELQNALNREQSLRKAAETQLTQASTELEELTAQLFSQANEMVAQERKARARLEERVAVLERRDIEKRNRLERLEKAMERVERIRALVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="126" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AX92</accession>
    <accession>C8VDE8</accession>
    <name>Q5AX92_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Hexose transporter protein (AFU_orthologue AFUA_8G04480)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ANIA_07088</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF79108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_664692.1">
        <property type="nucleotide sequence ID" value="XM_659600.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AX92"/>
    <dbReference type="GeneID" id="2870060"/>
    <dbReference type="KEGG" id="ani:ANIA_07088"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN7088"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_13_1"/>
    <dbReference type="InParanoid" id="Q5AX92"/>
    <dbReference type="OMA" id="TYVMEVC"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000117">
        <property type="entry name" value="MFS hexose transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
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    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF24">
        <property type="entry name" value="HEXOSE TRANSPORTER PROTEIN (AFU_ORTHOLOGUE AFUA_8G04480)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="208"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="274"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="307"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="375"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="1"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBF79108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="471" mass="52212" checksum="1929DD4FE85B3430" modified="2005-04-26" version="1">MTFGPTGGTLISVLISSQLRERFGRRYPICGGSIIIIVGGILQAAAVNYGMFVLSRFVVGFGLGIVATAAPPLLTEVAYPTHRGKLVSFYLVTWPLGSLIAAWVTYGTFKMEGSDWSWRIPSALQCFFSLVQAILALVAPESPRWLIYQGRSEEALAILTKYHGHGDADSRLVCFEMAEITATLEMEKVQRLSRWTEWLSTRGNRHRLFLACYIPAMLQWSGNALTSYYLAKVLVTIDITDPKTQLIINACLSVWGFLTAAVFATMVDRAGRRCLFLSGMGSMGVVYIIWTICSALNEKHNFEDKGYAGGVLAMIFVFSAAYHMCSPVAPTYIMEVVPFSLRSKAAMMYQLTGNLAGLYNSFANPVAMDAISWRYYIVWCVVIGVNFTLIFLFFPETKGKGLEEVAEIFDGPDALAGKNAMREMGLDVNADKDKVIFGTSYRRLFVTEVNTLLVAVIAEQWDCSRRLQGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="108" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AXB2</accession>
    <accession>C8VB34</accession>
    <name>Q5AXB2_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Aryl-alcohol oxidase vanillyl-alcohol oxidase (AFU_orthologue AFUA_3G09500)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ANIA_07068</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF79150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_664672.1">
        <property type="nucleotide sequence ID" value="XM_659580.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AXB2"/>
    <dbReference type="STRING" id="227321.Q5AXB2"/>
    <dbReference type="GeneID" id="2869945"/>
    <dbReference type="KEGG" id="ani:ANIA_07068"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN7068"/>
    <dbReference type="eggNOG" id="KOG1232">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024402_0_1_1"/>
    <dbReference type="InParanoid" id="Q5AXB2"/>
    <dbReference type="OMA" id="FCDFFMH"/>
    <dbReference type="OrthoDB" id="5332616at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004458">
        <property type="term" value="F:D-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008720">
        <property type="term" value="F:D-lactate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903457">
        <property type="term" value="P:lactate catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.10">
        <property type="entry name" value="FAD-linked oxidases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="entry name" value="Vanillyl-alcohol Oxidase, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016170">
        <property type="entry name" value="Cytok_DH_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-bd_oxidored_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11748:SF114">
        <property type="entry name" value="ARYL-ALCOHOL OXIDASE VANILLYL-ALCOHOL OXIDASE (AFU_ORTHOLOGUE AFUA_3G09500)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11748">
        <property type="entry name" value="D-LACTATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="FAD-linked oxidases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="5">
        <location>
            <begin position="89"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBF79150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="588" mass="65680" checksum="39F27E116A13C503" modified="2005-04-26" version="1">MAVYSPLDPFSLALTDKENEMANEVLSTWVGTASKSPTVNILPPGLDAPTWADVLQQFRSILGDEGVLCGHEHRVRYIDPYAEQSDEQEKRGSSATLFPVTVEHIQAILKICNKHKIPLWTVSRGKNLGYGGPAARVKGSIILDLQCMRKVLEMNDRYSYYTVEPGVTFCDIYREIQAQKKDIWCSVPALGWGSVVGNALDRGWGYTPAGDHSNQICGIEVVLADGTVVRTGAGAIDNSPCWPLFRGGYGPTYESMFSQSNFGIVTKLSLWATPSPEGFMNCRVDVENEEDLVPLIDIFRDLLLHDVIPNHPLIGNVPREMVKRGQRKDFYNGAGAIPDTRLKEIQTQLGIGFWSARFGLYGPKELIEYSFERCRRAFQSLPSAKLTGKAFYPPEGKTKLSPEDIPPADRTVETGTPSLMALKAVEYRGKDGGHISFSPVLPPEGSSAMAFYRDVKPLCAQYGFDYFGGLHLYPRHLAMINMIYFDRTSELERTNANKLFVELVHLARRHGYSEYRAHIDYMDLVADQYDFNGCSLRQLNERIKDALDPNGILSPGKQGIWPGRSRELTEKKDSYQGSSQRLLGLILC</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="99" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AXP4</accession>
    <accession>C8V368</accession>
    <name>Q5AXP4_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glutathione S-transferase kappa</fullName>
            <ecNumber evidence="1">2.5.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ANIA_06936</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily. Kappa family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="1"/>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF71777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_664540.1">
        <property type="nucleotide sequence ID" value="XM_659448.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AXP4"/>
    <dbReference type="GeneID" id="2870385"/>
    <dbReference type="KEGG" id="ani:ANIA_06936"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN6936"/>
    <dbReference type="HOGENOM" id="CLU_069253_1_3_1"/>
    <dbReference type="InParanoid" id="Q5AXP4"/>
    <dbReference type="OMA" id="FGAPWYV"/>
    <dbReference type="OrthoDB" id="4664297at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018845">
        <property type="term" value="F:2-hydroxychromene-2-carboxylate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004602">
        <property type="term" value="F:glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901170">
        <property type="term" value="P:naphthalene catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03022">
        <property type="entry name" value="DsbA_HCCA_Iso"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001853">
        <property type="entry name" value="DSBA-like_thioredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051924">
        <property type="entry name" value="GST_Kappa/NadH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014440">
        <property type="entry name" value="HCCAis_GSTk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044087">
        <property type="entry name" value="NahD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42943">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE KAPPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42943:SF13">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE KAPPA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01323">
        <property type="entry name" value="DSBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006386">
        <property type="entry name" value="HCCAis_GSTk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DSBA-like thioredoxin" evidence="3">
        <location>
            <begin position="7"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR006386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR006386-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBF71777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="216" mass="24596" checksum="515012A4608AE4DF" modified="2005-04-26" version="1">MAARPVIEYYFSFISLWSYIGSRRFQRLVQETNAHVIHKPIDLMYIFSISGGLPVKQRSAQRQAYRLLEMERWRRIHGIPIVQNPKYYPADPSLAHRVLLAAIEESGNDSLAVQEFARLGLEAVWARELDIANEATIVQLAKEAGLSGDRLLQRAKTEPLLADQETALTKEAEIRQYFGAPLYSFRGEPFWGQDRLDMLDDAIKSGRDPIVVPSLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="129" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AXP7</accession>
    <accession>C8V365</accession>
    <name>Q5AXP7_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Malic enzyme</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">ANIA_06933</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(S)-malate + NAD(+) = pyruvate + CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:12653"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.38"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>oxaloacetate + H(+) = pyruvate + CO2</text>
            <dbReference type="Rhea" id="RHEA:15641"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="EC" id="1.1.1.38"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="10">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="10">Divalent metal cations. Prefers magnesium or manganese.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the malic enzymes family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF71772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_664537.1">
        <property type="nucleotide sequence ID" value="XM_659445.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AXP7"/>
    <dbReference type="FunCoup" id="Q5AXP7">
        <property type="interactions" value="858"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5AXP7"/>
    <dbReference type="GeneID" id="2870383"/>
    <dbReference type="KEGG" id="ani:ANIA_06933"/>
    <dbReference type="eggNOG" id="KOG1257">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011405_5_2_1"/>
    <dbReference type="InParanoid" id="Q5AXP7"/>
    <dbReference type="OMA" id="EVPVTPW"/>
    <dbReference type="OrthoDB" id="5365701at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004471">
        <property type="term" value="F:malate dehydrogenase (decarboxylating) (NAD+) activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd05312">
        <property type="entry name" value="NAD_bind_1_malic_enz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10380:FF:000001">
        <property type="entry name" value="NAD-dependent malic enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000055">
        <property type="entry name" value="NAD-dependent malic enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10380">
        <property type="entry name" value="Malic enzyme, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015884">
        <property type="entry name" value="Malic_enzyme_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012301">
        <property type="entry name" value="Malic_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037062">
        <property type="entry name" value="Malic_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012302">
        <property type="entry name" value="Malic_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001891">
        <property type="entry name" value="Malic_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010052">
        <property type="entry name" value="PRK13529.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23406">
        <property type="entry name" value="MALIC ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23406:SF34">
        <property type="entry name" value="NAD-DEPENDENT MALIC ENZYME, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00390">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03949">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000106">
        <property type="entry name" value="ME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00072">
        <property type="entry name" value="MALOXRDTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01274">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00919">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00331">
        <property type="entry name" value="MALIC_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="4 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Malic enzyme N-terminal" evidence="13">
        <location>
            <begin position="87"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Malic enzyme NAD-binding" evidence="12">
        <location>
            <begin position="284"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="429"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="475"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00050168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00052591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CBF71772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="581" mass="64482" checksum="8E6F4F96A2354409" modified="2005-04-26" version="1">MSLARFKHLPRATQGPIKCPYKGAALLGNANYNKGSAHSERERREFNLHGLLPPNIQTLDEQVERAYQQYKSRPDDLAKNTFMASMKSQNQVLYYRLLQTHLKEMFSVIYTPTEADAIQNYSRLFRKPEGCYLSIRDHGEKEIDECFANFSGGDDVDYIVVSDGEQWQILGIGDQGVGAILISVAKLVITTACAGIHPSRQLPVVLDCGTNNEELLNDKLYLGLRQRRAQGEEYDKFVDKFVRMARKRFPNAYIHLCSEDFGLQNAKRILDRYRSQLPCFNDDIQGTGCVTLAALMAGLHVSNVKLKDVRVVCYGSGSAGTGIADQISDAIATEAGFSKSDALKQIWCIDKQGLLLKSQGDALTASQKYFAKEDNEWPEGQDIDLYSVIKHVKPHVLIGTSTKPGSFTEETIREMAKHVDRPIIFPLSNPTRLHEAQPQDITKWTDGKALIATGSPFPPVEYNGTKTEIVSAECNNSTAFPGIGLGAVLSRASRLSEKMVVAASKALAAKAPALEDPNKPLLPDVENVRELSLNVAKAVIQTAVKEGLAQEEGIPEDEKDLEDWIRAQMWEATYRDLEKAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="124" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AYP5</accession>
    <accession>C8V120</accession>
    <name>Q5AYP5_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ANIA_06585</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DEAD box helicase family. DEAH subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF71041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_664189.1">
        <property type="nucleotide sequence ID" value="XM_659097.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AYP5"/>
    <dbReference type="FunCoup" id="Q5AYP5">
        <property type="interactions" value="1190"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5AYP5"/>
    <dbReference type="GeneID" id="2870655"/>
    <dbReference type="KEGG" id="ani:ANIA_06585"/>
    <dbReference type="eggNOG" id="KOG0926">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001832_0_4_1"/>
    <dbReference type="InParanoid" id="Q5AYP5"/>
    <dbReference type="OMA" id="EAIHNNS"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd17982">
        <property type="entry name" value="DEXHc_DHX37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000637">
        <property type="entry name" value="ATP-dependent RNA helicase DHX37/DHR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF99">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX37-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="383"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="583"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="84"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="922"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="34"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="144"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
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            <begin position="197"/>
            <end position="208"/>
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    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="219"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CBF71041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="956" mass="106177" checksum="E5FFDB8BDAE9F725" modified="2005-04-26" version="1">MPKFVPRQRKQKHRQQAANAAVDTNAAEIQPLSKSEREARKEKLREELRAQHTKISAKKQKRLDKYIENKLKKEENTALLKKLAQSKVEVTGLQSSKELGKRKREDDEAPRLTADAAEERNAPEYSSDETDDDLSGLKSDATGKGQQEQKASTLMNGIGLKRPLELGPDGFPILKKRKRAPKAAPKAPLNEIPWEGFDSDDEDKEEEIGPGIDAKSEEEGTGSDDSSESESEVDDNGDSGSDEDEDRKDEEDEDEDEDEDVDDDEDEDEDDEKEDDDDEDEDENNTDGRIKPRQSAFKSWARQQINEVVGFKPTSGPITTEPQVIPKSALPVRAVEEEPLPLELQVTKGNPYRKAFSVQVDRPEHIQEARLKLPVVGEEQKIMEAIHNNSAIVIWGATGSGKTTQLPQFLFESGYGNPESGNPGMIGVTQPRRVAAVSMAKRVGDELGQFSSQVSYQIRFESTASSKTAIKFMTDGILIREIAEDFSLSKYSIIVIDEAHERSVNTDILIGMVSRIVDLRKTMSEEDPSVKPLKLVIMSATLRISDFTQNASLFRQGPPPLVQAEGRQYPVTIHFSRRTHRDYVEEAFRKVSRGHRKLPPGAILVFLTGQNEIRQLSKRLKQAFKPTQRGEVTNAKVQISANEAPLEAEDLEIGEADITNTANTNAYGYDDDDSDLEITGLDDPEEDEEFNVGEEGEEAMDSSTKVHVLPLYSQLPTKEQLRVFEPPPEGSRLIVLATNVAETSLTIPGIRYVFDCGRAKEKQYDLETGVQKFQINWISKASANQRAGRAGRTGPGHCYRLYSSAIYEGEFAEYTDPEILRTPIEGVVLQMKSMGLHNVINFPFPTPPSRQGLAKAEKLLKNLGALTADGKITPVGNSLSTYPLSPRFGKMVYVGHQHGCMPYVIALVAALAVGDLFVPENQIDPHPGKEDNEDNGVYKNSDRLEDTARTQGGYAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AZE7</accession>
    <accession>C8V108</accession>
    <name>Q5AZE7_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_06333</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF69682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_663937.1">
        <property type="nucleotide sequence ID" value="XM_658845.2"/>
    </dbReference>
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    <dbReference type="STRING" id="227321.Q5AZE7"/>
    <dbReference type="GeneID" id="2871228"/>
    <dbReference type="KEGG" id="ani:ANIA_06333"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN6333"/>
    <dbReference type="eggNOG" id="ENOG502S25T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_573662_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AZE7"/>
    <dbReference type="OMA" id="RYERSHN"/>
    <dbReference type="OrthoDB" id="2359117at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="373"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="282"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="374"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="398"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CBF69682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="476" mass="51783" checksum="1DF01CDBC0873C33" modified="2005-04-26" version="1">MLDGSLQVHRRQGAQGQGRTHRRENISNIDVPNGLDRYQGRTTGMRPLSLDASSNMQRTAEGISVDCQVWRHESSAVPLEGYTSPQDKSTAGGETVPKEAGGLETSRQIDIERTEASGHTRSSTNLPGAQHSPRVGDIGRRRSQSTGFGSRGSRIAALSVQLRTRLSYAAARIEKARQSQSQYQSPTGLLQKNSSTPILSVETLSRTGQPSLGEPGDQFEAGSPDGTTVSAPDAPAASSRHPFEGPIRQTLNATIDVNSQTQPDLNKHAEYHPELRPPRLAPPADIDPGRVNRQRRRPNPNNPSNPSRYAPFPLHRRGRSQQELVADTEVTRVPETPPLCPSNDNGIPFHGWSDNSQSSSMEQDAIETLLFMSSPGTSGYHSNSQNSQRNQDVRNIDDSASQSVKWHGSLNGTQSDRQSGLTGTVETRTGDEIDLMLDQMNSDSDDDADYTFRRSIRVEAGSRANDAVGSNVQHGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AZH9</accession>
    <accession>C8V191</accession>
    <name>Q5AZH9_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_06301</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF69750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_663905.1">
        <property type="nucleotide sequence ID" value="XM_658813.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AZH9"/>
    <dbReference type="GeneID" id="2870975"/>
    <dbReference type="KEGG" id="ani:ANIA_06301"/>
    <dbReference type="eggNOG" id="ENOG502STCV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_135725_1_0_1"/>
    <dbReference type="InParanoid" id="Q5AZH9"/>
    <dbReference type="OMA" id="RQQGYGP"/>
    <dbReference type="OrthoDB" id="5386823at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF69750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="111" mass="12072" checksum="0ADECAA133C9E562" modified="2005-04-26" version="1">MTDTKLMDIEAGGEQTQYEGVRQFSKTPEKQTGQLGYNLPHTKSQTRTTLAGDHSEAKAKREDSKLAHKLELGERTSGITGYTNESSDETEHDAAKSRREQGYGPGSGIGA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-10-31" modified="2025-06-18" version="120" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AZQ5</accession>
    <accession>C8V1S0</accession>
    <name>FIS1_EMENI</name>
    <protein>
        <recommendedName>
            <fullName>Mitochondrial fission 1 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">fis1</name>
        <name type="ORF">AN6225</name>
    </gene>
    <organism>
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Has a role in mitochondrial fission. Has a role in outer membrane fission but not matrix separation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">The C-terminus is required for mitochondrial localization, while the N-terminus is necessary for mitochondrial fission.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FIS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="AACD01000106">
        <property type="protein sequence ID" value="EAA57639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF69911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_663829.1">
        <property type="nucleotide sequence ID" value="XM_658737.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AZQ5"/>
    <dbReference type="SMR" id="Q5AZQ5"/>
    <dbReference type="FunCoup" id="Q5AZQ5">
        <property type="interactions" value="663"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5AZQ5"/>
    <dbReference type="EnsemblFungi" id="CBF69911">
        <property type="protein sequence ID" value="CBF69911"/>
        <property type="gene ID" value="ANIA_06225"/>
    </dbReference>
    <dbReference type="KEGG" id="ani:ANIA_06225"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN6225"/>
    <dbReference type="eggNOG" id="KOG3364">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104368_2_0_1"/>
    <dbReference type="InParanoid" id="Q5AZQ5"/>
    <dbReference type="OMA" id="QFNYAWG"/>
    <dbReference type="OrthoDB" id="421154at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd12212">
        <property type="entry name" value="Fis1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000179">
        <property type="entry name" value="Mitochondrial fission 1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016543">
        <property type="entry name" value="Fis1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033745">
        <property type="entry name" value="Fis1_cytosol"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028061">
        <property type="entry name" value="Fis1_TPR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028058">
        <property type="entry name" value="Fis1_TPR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13247:SF0">
        <property type="entry name" value="MITOCHONDRIAL FISSION 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13247">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 11 TPR REPEAT PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14853">
        <property type="entry name" value="Fis1_TPR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14852">
        <property type="entry name" value="Fis1_TPR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF008835">
        <property type="entry name" value="TPR_repeat_11_Fis1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0802">TPR repeat</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000256185" description="Mitochondrial fission 1 protein">
        <location>
            <begin position="1"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="2">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="topological domain" description="Mitochondrial intermembrane" evidence="2">
        <location>
            <begin position="149"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR">
        <location>
            <begin position="75"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="153" mass="17064" checksum="9569B9033F635A0B" modified="2005-04-26" version="1">MTSSNLPYAADAESPLKPAELQVLRAQYEKEGDYVGVQTKFNYAWGLIKSNFRADQQEGVRLLSEIFRAHPERRRECLFYLALGNYKLGNYGEARRYNDLLIDKEPGNLQAASLRTLIDDRVSREGMVGIAIVGGLALAAGVVGGLLFRGQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="105" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AZU9</accession>
    <accession>C8V227</accession>
    <name>Q5AZU9_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">60S ribosomal protein L44 P (Broad)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ANIA_06181</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL42 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF70023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_663785.1">
        <property type="nucleotide sequence ID" value="XM_658693.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AZU9"/>
    <dbReference type="FunCoup" id="Q5AZU9">
        <property type="interactions" value="697"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5AZU9"/>
    <dbReference type="GeneID" id="2871075"/>
    <dbReference type="KEGG" id="ani:ANIA_06181"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN6181"/>
    <dbReference type="eggNOG" id="KOG3464">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114645_2_1_1"/>
    <dbReference type="InParanoid" id="Q5AZU9"/>
    <dbReference type="OMA" id="CKKHTIH"/>
    <dbReference type="OrthoDB" id="2967263at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.80:FF:000001">
        <property type="entry name" value="60S ribosomal protein L44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000552">
        <property type="entry name" value="Ribosomal_eL44"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053708">
        <property type="entry name" value="Ribosomal_LSU_eL42"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10369">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L36A/L44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00935">
        <property type="entry name" value="Ribosomal_L44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01172">
        <property type="entry name" value="RIBOSOMAL_L44E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBF70023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="106" mass="12110" checksum="0FC263DE0BFD4901" modified="2005-04-26" version="1">MVNVPKTRKTYCKGKECHKHTQHKVTQYKAGKASLFAQGKRRYDRKQSGYGGQTKPVFHKKAKTTKKVVLRLECTQCKTKKQLALKRCKHFELGGDKKTKGAALVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B1C8</accession>
    <accession>C8VFU4</accession>
    <name>Q5B1C8_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ANIA_05652</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxoprolinase family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF81473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_663256.1">
        <property type="nucleotide sequence ID" value="XM_658164.2"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5B1C8"/>
    <dbReference type="GeneID" id="2871944"/>
    <dbReference type="KEGG" id="ani:ANIA_05652"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN5652"/>
    <dbReference type="eggNOG" id="KOG1939">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002157_0_1_1"/>
    <dbReference type="InParanoid" id="Q5B1C8"/>
    <dbReference type="OMA" id="PVVEFYM"/>
    <dbReference type="OrthoDB" id="3643at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017168">
        <property type="term" value="F:5-oxoprolinase (ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049517">
        <property type="entry name" value="ACX-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008040">
        <property type="entry name" value="Hydant_A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002821">
        <property type="entry name" value="Hydantoinase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003692">
        <property type="entry name" value="Hydantoinase_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045079">
        <property type="entry name" value="Oxoprolinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365:SF9">
        <property type="entry name" value="5-OXOPROLINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365">
        <property type="entry name" value="5-OXOPROLINASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19278">
        <property type="entry name" value="Hydant_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05378">
        <property type="entry name" value="Hydant_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01968">
        <property type="entry name" value="Hydantoinase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02538">
        <property type="entry name" value="Hydantoinase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydantoinase/oxoprolinase N-terminal" evidence="4">
        <location>
            <begin position="7"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="Hydantoinase A/oxoprolinase" evidence="2">
        <location>
            <begin position="240"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="domain" description="Acetophenone carboxylase-like C-terminal" evidence="5">
        <location>
            <begin position="542"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="domain" description="Hydantoinase B/oxoprolinase" evidence="3">
        <location>
            <begin position="735"/>
            <end position="1270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF19278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBF81473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="1307" mass="140840" checksum="8CBDEBF52D9CA97E" modified="2005-04-26" version="1">MATQGVRIAIDRGGTFTDCWAEVPGRKEHIVFKILSVCPDEYDDAPTECIRQVLEIASGTSIPKGSLLDLEPIESIRMGTTVATNALLERKGDRVAFLVTKGFRDILFIGNQTRPNLFDLTVQRLEQLYETVIEVDERITIEGASEAPQPEEPIDVSSDPDLVVGQTGEIVRIMKKPDLDAVREDLEKLKAQGLKNIAIGFMHSYTYPEHELQVQRLAEDMGFKVSASSVLQSMAKFVPRSQSAVADAYLTPMTFAYLDGFRKNFKGQLEDESANKLLICQSDGGLTSWSKFTGLRGVLSGPAGGVVGLSRTCYDEADGTPVLGFDMGGTSTDVARYSGALEHIFESTLAEVTIQTPQLDINTVAAGGGSILAWENGLLKVGPSSAGANPGPACYGRGGPLTVTDANFLLGRIIPETFPRKLDYDTVKEKFSALAETVNKEKDGGEPFTPETLALGFLAIANATMTRPIRTLSEGRGYGAASHNLGCFGGAGGQHAVFIARDLGIKRAIIPCYSSILSAYGMALADVVVENQEPAALTFSEAAVPEIRARFESLSSRGAKGLKAQGFDASVTEHEYFLNMRYQGSDTSLMIALTGDVADAGNAFTARHTQEFGFSQTRDILVDDVRVRSVGKSRVLNISSPFEELKKYSSDGLTPCPTPVFSRQIFFEKYGWTQTPVYELKSLSAGVHITGPAMVIDKTQTIVVDHLSKAIILPEHVILEVERAEQQTVDTQTVDPVQLSVFGHRFMTVAEQMGHTMEKTSISVNIKERLDYSCAIFSADGGLVANAPHIPSHLGSMSTAIAYQAQKYKADLKPGDVLISNHPRAGGTHLPDITTITPVFDDEDKEIIFFVANRGHHADIGGIVPGSMPPNSTELWQEGAAIESFKMIKEGVFDEAGLIKHLYEEPASFPGCSGTRTLAENIADLKAAVASNQKGIELIRALVKEFTWPVVQLYMYAIQENAAQAVRDLLKQFAAKYEGGVLEATEYNDDGIPFKLKVTIDKDTGDAVFDFTGTGPEHSGNLNAPPTCSYSVIMYCLRCMISTDIPLNQGCLKPIKVVCPDNTILSPSPTAATVGCTTETSQKVADLVLRAFNAAAASQGTMNNLSFGCGGTDPVTGEVKKGFGYYETICGGAGAGLGWQGASCTQVHMTNTRITDPEIFEKRYPVILHQFSIRHGSGGNGRWRGGDGCIREIEFRMPLQVSVLSDRRVTAPYGLEGGSDGERGQNIWVRKDPVTGATRMVSLGPRKTSMFGAGDRIIILTPGGGGYGAPVKDGEGVKETVFVKPQDSRSFLTNGSLGVRHSIATGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B1J3</accession>
    <accession>C8VG18</accession>
    <name>Q5B1J3_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_05587</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF81610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_663191.1">
        <property type="nucleotide sequence ID" value="XM_658099.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B1J3"/>
    <dbReference type="GeneID" id="2871878"/>
    <dbReference type="KEGG" id="ani:ANIA_05587"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN5587"/>
    <dbReference type="eggNOG" id="ENOG502SD7X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054588_0_0_1"/>
    <dbReference type="InParanoid" id="Q5B1J3"/>
    <dbReference type="OMA" id="DIVLLRM"/>
    <dbReference type="OrthoDB" id="5378679at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="336"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF81610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="361" mass="39841" checksum="7FBAEFB51273C069" modified="2005-04-26" version="1">MSSRTIFLMGAPTFSSLRWDERDLLSESLPPFEDSKGCRERFGVFSGSTPVKWRLLSAPIVPKTTQSKPSQVMTGETRFFTTHDLATSVGKCASEQEDSELSQFYDHSFTVHETSEVSAPSALSGESALDSGLWTVSTDTSIATSDEREIPAARPHIQGGITDLKDIPNTVYLNSIVPQTMTVNLVVAIIDIRSPRRVITKHWKRELDLVEVVVGDETRAGFGVTFWLPPADENAVNTRGCGDGAGEELRASLMALRPRDIVLLRNVGLSCFQDRVYGQSLRRGYTKIDLLHRQQVDATDTGGIYRIRDILSHPAKDDDLPLVKVRKVHEWIRRFVPDSAGGGSNGPRMTTLPPDSQDGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B2B1</accession>
    <accession>C8VGV8</accession>
    <name>Q5B2B1_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_05319</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF82107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_662923.1">
        <property type="nucleotide sequence ID" value="XM_657831.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B2B1"/>
    <dbReference type="STRING" id="227321.Q5B2B1"/>
    <dbReference type="GeneID" id="2871608"/>
    <dbReference type="KEGG" id="ani:ANIA_05319"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN5319"/>
    <dbReference type="HOGENOM" id="CLU_054243_1_0_1"/>
    <dbReference type="InParanoid" id="Q5B2B1"/>
    <dbReference type="OMA" id="RYTHPSF"/>
    <dbReference type="OrthoDB" id="5275938at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="318"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF82107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="338" mass="37834" checksum="8E4151B0832B59D4" modified="2005-04-26" version="1">MSTEVIDPYGDIIVACSNVNFLVSSNALSLASPVFYSMFRPGIKEGLAVRGIPGSLDVPVIPFPDDDSDTFLLFCNLAHHKLPALPETLNATLLKDLAVFIVKYACRPAIIDRGWLWITKDELSAELSPEDCWNALLFAYAMDLPDRFSYFSGKLLSSRRQSFSNWDYALANLEFIPHHVLEQLDIKQALLHFNVETALMEIVSVAQTKSSKECRKLKMFLGSYSQILWKAGILPGMLELRRKTLPQIMQCALGLPAISYNPGSGECDGYYNECYCSHANELDIKQHLLKELMKCAEDEQAGICLLCVKREPCDKHPRLHKEDGNLGNEEKEVSGPAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B2U5</accession>
    <accession>C8VEZ7</accession>
    <name>Q5B2U5_EMENI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_05135</name>
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    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
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            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
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        <property type="protein sequence ID" value="CBF80925.1"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    </feature>
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    </evidence>
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        <source>
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<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B3P4</accession>
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            <fullName evidence="7">SD08430p (AFU_orthologue AFUA_3G07290)</fullName>
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        <name evidence="7" type="ORF">ANIA_04836</name>
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        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
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    <reference evidence="8" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
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            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
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                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
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            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
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        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
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    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_657348.2"/>
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    <dbReference type="FunCoup" id="Q5B3P4">
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    <dbReference type="KEGG" id="ani:ANIA_04836"/>
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    <dbReference type="eggNOG" id="KOG3574">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:acetyl-CoA transmembrane transporter activity"/>
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        </source>
    </evidence>
    <sequence length="576" mass="63731" checksum="5951E91280BE96AF" modified="2005-04-26" version="1">MKRKNNTVSKRRSKPNLSVATGQNGNAHGKMNSNIEMRKRDTSTGSSSSARADRFMSRSSFTLDQDPPTPQTPGMTTTSFSDLPSSDKRNFMLLCLLYFLQGVPMGLATGSVPFLLKPYLSYGQIGVFSLASYPYSLKLLWSPIVDAVWSRRFGRRKSWITPVQVIAGLAMIYLGGHIEDMMKQAGANGGAGVWKFTYWWFLLVFFCATQDIAVDGWAITLMSPPNISYASTAQTVGLTAGHFLSYTVFLAFNSKDFANRWFRTTPAEGGLLSLGTYLTIWGWAYLVVTTCLALMKKEDHVSERDSISAVYRSMWSVLKLKNVQTIIIVHLIAKIGFQANDGVTSLKLLDKGFGQDNMALVVLIDFPFEIGLGYYAGKWSTEYTPMRLWCWAFVGRLAAAILAQFTVMIYPSAPEVPTWYMLTVIFEHVASTFMNTVMFVAVSAFHARVSDPAIGGTYMTMLATVSNLGGTFPRYFILKLVDMFTEATCVPPTTNPSPGSLKGDLVTSPFSCAVEPDRTRCIDGGGTCDITRDGYYMTNILCVLVGTVTFIMFIKPAVLKLQSLPLRAWRLAPGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="135" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B460</accession>
    <accession>C8VB09</accession>
    <name>Q5B460_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcription factor (SPT8), putative (AFU_orthologue AFUA_5G09080)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ANIA_04670</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF77033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_662274.1">
        <property type="nucleotide sequence ID" value="XM_657182.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B460"/>
    <dbReference type="FunCoup" id="Q5B460">
        <property type="interactions" value="339"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5B460"/>
    <dbReference type="GeneID" id="2872469"/>
    <dbReference type="KEGG" id="ani:ANIA_04670"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN4670"/>
    <dbReference type="eggNOG" id="ENOG502QS8F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010934_1_0_1"/>
    <dbReference type="InParanoid" id="Q5B460"/>
    <dbReference type="OMA" id="WDRRQPN"/>
    <dbReference type="OrthoDB" id="10260946at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900237">
        <property type="term" value="P:positive regulation of induction of conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000789">
        <property type="entry name" value="Transcription factor (SPT8), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000927">
        <property type="entry name" value="Transcription factor (SPT8), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057544">
        <property type="entry name" value="Beta-prop_SPT8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF8">
        <property type="entry name" value="F-BOX AND WD REPEAT DOMAIN CONTAINING 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23798">
        <property type="entry name" value="Beta-prop_SPT8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Transcription factor spt8 beta-propeller" evidence="5">
        <location>
            <begin position="108"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="228"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="457"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription factor spt8 beta-propeller" evidence="5">
        <location>
            <begin position="463"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="281"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="400"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="55"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="296"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="416"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="454"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBF77033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="643" mass="69038" checksum="82AA29965E7B58DC" modified="2005-04-26" version="1">MASIVEDEDDRDIAGSQDGSSDNDMDDTLRDADEGGGDNEPDMDADGDADDQDADSASNASHASESAEVATQQNQETTMTPVPDNATTDLTSVFHPSVRPECLTASSYDIVPTTAAPHSTSINAITATADMRWVFSGGSDGYVRKFNWVDSINSKLMLTVAQRHPFVDSVIKAGVLMTYWENMDGNALSPVYSLACQSEGLWLLSGLESGSIRLQSIRHDEGKEIALLQQHTSAVSVLSLTSDEKSLLSGSWDKRIYDWDLNTGQTRRVFGSSAGQISAIELRPESSLPVPRDTTEIQQPNGTFSSNNQASGGNSFSYMDTTNDQGDNDAVNPQAGSPADSLFGGADSLFGDADGTAGDGLGTATNSFGIDDDDEFGKALTNGVAPDADAAGEPDTVQQKNLFDSKDPSNDAPGVDSNTLVPNQPLDSHSTDAVNNQSQPLVNGLPHAEELEPPSQSQEHTQSTPTEASNDNDNTFLAASIDGTIRVWDRRQPSAIARITPRNSPPWCMNACWSPDGNYIYAGRRNGTVEEYSLHKGLREPERTFKFPQGSGPVTALKAMPNGRHLLCASHDILRLYDLKHEQATRHSTVPFLIIPGHRTGTVSQLYVDQACRFLVSTSGNRGWEGSTTEVLLGYEIGVPVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="111" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B4E4</accession>
    <accession>C8V7V3</accession>
    <name>Q5B4E4_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">C2H2 finger domain protein, putative (AFU_orthologue AFUA_2G02080)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">ANIA_04586</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in transcriptional regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF77201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_662190.1">
        <property type="nucleotide sequence ID" value="XM_657098.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B4E4"/>
    <dbReference type="GeneID" id="2872381"/>
    <dbReference type="KEGG" id="ani:ANIA_04586"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN4586"/>
    <dbReference type="eggNOG" id="ENOG502SXT7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081645_1_0_1"/>
    <dbReference type="InParanoid" id="Q5B4E4"/>
    <dbReference type="OMA" id="PPMEHSY"/>
    <dbReference type="OrthoDB" id="2687452at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000771">
        <property type="entry name" value="zinc finger protein 648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="153"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CBF77201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="226" mass="24985" checksum="BB14B382187E6029" modified="2005-04-26" version="1">MSFRPTMSQPIACPPMEHSPSSLSSYSSYSPSSSYSAVSDDSGMSMLDMYFLHGGRGHGASPGTSTGPGSVVDFPLSQQSFDFEPSSLDSNGPYFEFNPTFVYTPEAFPVMDAPTSYPASSNPAWSPTSMLVEQSIFPLDGLSQEPVKPAKPYSCEDCGKAFTRPADLKRHHSTVHYPVFQNCPVPDCSRKDNHGFPRRDHLVEHLRSYHHMDVPKRRAAKRLRTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B4X8</accession>
    <accession>C8V8U0</accession>
    <name>Q5B4X8_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Mitochondrial outer membrane protein porin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">ANIA_04402</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Forms a channel through the cell membrane that allows diffusion of small hydrophilic molecules. The channel adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic mitochondrial porin family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF77600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_662006.1">
        <property type="nucleotide sequence ID" value="XM_656914.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B4X8"/>
    <dbReference type="SMR" id="Q5B4X8"/>
    <dbReference type="FunCoup" id="Q5B4X8">
        <property type="interactions" value="1065"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5B4X8"/>
    <dbReference type="GeneID" id="2872202"/>
    <dbReference type="KEGG" id="ani:ANIA_04402"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN4402"/>
    <dbReference type="eggNOG" id="KOG3126">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044399_0_0_1"/>
    <dbReference type="InParanoid" id="Q5B4X8"/>
    <dbReference type="OMA" id="FKQPAFH"/>
    <dbReference type="OrthoDB" id="7827681at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046930">
        <property type="term" value="C:pore complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015288">
        <property type="term" value="F:porin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008308">
        <property type="term" value="F:voltage-gated monoatomic anion channel activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd07306">
        <property type="entry name" value="Porin3_VDAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.10:FF:000004">
        <property type="entry name" value="Por1 mitochondrial outer membrane porin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.10">
        <property type="entry name" value="Porin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023614">
        <property type="entry name" value="Porin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001925">
        <property type="entry name" value="Porin_Euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027246">
        <property type="entry name" value="Porin_Euk/Tom40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11743:SF70">
        <property type="entry name" value="GH26960P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11743">
        <property type="entry name" value="VOLTAGE-DEPENDENT ANION-SELECTIVE CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01459">
        <property type="entry name" value="Porin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00185">
        <property type="entry name" value="EUKARYTPORIN"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="8" id="KW-0626">Porin</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1134">Transmembrane beta strand</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00054641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00073272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CBF77600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="284" mass="29910" checksum="AFB2FE8279C6D72C" modified="2005-04-26" version="1">MAAPAAFSDIAKAANDLLNKDFYHGSAASLEVKSKAPNGVTFNVKGKSAHEGPIAGSLEAKYVDAPTGLTLTQAWTTANALDTKLELDNNIAKGLKAEIITQYLPAKQSKGAKLNLHFKQPNLHARAFFDLLNGPSANFDAVLGHEGFLVGAEGGYDVQKAAITKYSAAVGYSVPQYSAAIQAANNLTVFSASYYHRVNAQVEAGAKATWDSKTGNSVGLEVASKYRLDPSSFAKVKINDRGIAALAYNVLLRPGVTLGLGASFDTQNLNQAAHKVGASFTFEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="99" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B517</accession>
    <accession>C8V8Y0</accession>
    <name>Q5B517_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ANIA_04363</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF77678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_661967.1">
        <property type="nucleotide sequence ID" value="XM_656875.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B517"/>
    <dbReference type="STRING" id="227321.Q5B517"/>
    <dbReference type="GeneID" id="2872161"/>
    <dbReference type="KEGG" id="ani:ANIA_04363"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN4363"/>
    <dbReference type="eggNOG" id="ENOG502SJ3M">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018354_0_1_1"/>
    <dbReference type="InParanoid" id="Q5B517"/>
    <dbReference type="OMA" id="PVNMAFE"/>
    <dbReference type="OrthoDB" id="9996127at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF8">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030175768" description="FAD-binding PCMH-type domain-containing protein" evidence="5">
        <location>
            <begin position="19"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="77"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBF77678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="518" mass="57351" checksum="88E2F7B13F29FB11" modified="2005-04-26" version="1">MQVRGFLFLAYSLTLVGPQAVARSAADNPDLFPRQHQQLSVAEIQRELNSILSPRSIIFGVDDARYVNATKPWNTVATPHIQLVIQPGEEADVSTIVSYCNENNVPFLARDRAHGGASSLNAFTGIQIDLSPFSEITIDSSGTSARFGGGVYGGQVVSYLWDRGYVTPTGACDCVSVMGPGLGGGHGRLEGLYGMISDNILQLNVVLGNGTAITVNSTSHPDLYWAMRGAGHNFGIVTSFESKIYLRGPETWHYHNYVWAGEQLEVLFRALNALHKNGFGSTPVNMAQNWGSFFMNETIDAQNPLIRWYFAYHGSAEAAAPLLAPFNAIPALFEESGDLPYPEIAATQGLDSESVVCQHGYRIVSATAGLQVYNVTAERRIFESFRRRIGSNRALARGGVIEHDGYSTAGVEAFDPDDSAYPFRSDRHLMLINIGIALDNTDSELQREAWEWAGEVRDMWNEGQPGRKAHAYVNYANGFEPVEEKYGHEAWRLERLRVLKERYDPDNRIRFYNPIIQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="100" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B5F6</accession>
    <accession>C8V4A7</accession>
    <name>Q5B5F6_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DUF887 domain protein (AFU_orthologue AFUA_1G06320)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ANIA_04224</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
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            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
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    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF74448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_656736.2"/>
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    <dbReference type="KEGG" id="ani:ANIA_04224"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN4224"/>
    <dbReference type="eggNOG" id="KOG4561">
        <property type="taxonomic scope" value="Eukaryota"/>
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        <property type="entry name" value="TOPOISOMERASE I DAMAGE AFFECTED PROTEIN 4"/>
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        <property type="entry name" value="TRAM_LAG1_CLN8"/>
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    <proteinExistence type="predicted"/>
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            <end position="54"/>
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            <begin position="365"/>
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            <dbReference type="ARBA" id="ARBA00022989"/>
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            <dbReference type="PROSITE-ProRule" id="PRU00205"/>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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            <dbReference type="EMBL" id="CBF74448.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
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    <sequence length="390" mass="44467" checksum="F8C06398FB58DB79" modified="2005-04-26" version="1">MLDPIPPPPEWLREYTEPWAQRFNLPALTDHSHEVIAAFIGYLFIHYVLSPWLSPKLFPRHYPNLNKRTKLNWDVHVVSLVQSSFINAVALWVLFADEERKSMTIGERVFGYTGSCALINSLAVGYFIYDLIISTLYVKMFGIGMLFHAVSALWVFSFGFRPFVNFYAPVFILYELSSPFLNIHWFLDKVNMTGSKLQWYNGMALLVVFFCCRLIWGTWQSVLVYMDMFAALRQTWSAGSSSPLDPVNITAQIFQTRDDGSLCINEACIKANAEITKYSKHTAVGVPTWLVATYVTSNLILNSLNYYWFSKMIETVMKRFRPQKEQSKVAEKLKEHNKEASAVEELAQQAVLDAASKLEQEEGSLFLGDNEQPVASGVDASTSDLRNRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B5K7</accession>
    <accession>C8V4N9</accession>
    <name>Q5B5K7_EMENI</name>
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        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ANIA_04173</name>
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    <organism evidence="10 11">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
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        <property type="protein sequence ID" value="CBF74556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_656685.1"/>
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    <dbReference type="KEGG" id="ani:ANIA_04173"/>
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        <property type="component" value="Chromosome II"/>
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        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS"/>
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        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511:SF4">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="128"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="182"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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            <end position="252"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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            <begin position="333"/>
            <end position="354"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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            <begin position="374"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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            <begin position="425"/>
            <end position="447"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="459"/>
            <end position="481"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="487"/>
            <end position="508"/>
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    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="60"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBF74556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="516" mass="55700" checksum="AF2065FD359CFB29" modified="2005-04-26" version="1">MSFLIKNPFTTESRVGGNHPPTGGEDTSLQKELATVDEVLAKKMASVNSAIDEIGMTPFQWKLFFLNGFGYAVDSLLVVCQSIAQPAVTQEFGNPSKHIAGVALASQIGLLVGAAVWGFSADVIGRKLAFNSSLFICATFVLIAGGMPNYVSFCAMVAIYSAGAGGNYVLDATNFLEFLPVSHSWLVTFLAVWWAVGYTITGLLAWAFMSNYSCHPDATVAECTRAANMGWRYLHITCGGLVLVASILRLVLIRMAETPKWLVSQNRDDELIEILSNLSKKYNRPFSLTLEELSSQGRVQGTEKSVFSALRLASHFTGLFSTKKLTYSTVMIIINWLLIGTVSPLYSVFLPYYLQSRGADTGDNSNYTTWRNYAINQVAGLIGPVIAAVLVELRLIGRRRTLAIGAAVTTALQFGYTQIKTPAQNVGVSAAITAASNIYYGTIYAYTPEILPSSHRATGYGLCVVLNRVGGIVGVLVGSFANVQTTVPLFICAGIYAALIITSLSLPFESRGKRTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B5K8</accession>
    <accession>C8V4P0</accession>
    <name>Q5B5K8_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_04172</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF74558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_661776.1">
        <property type="nucleotide sequence ID" value="XM_656684.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B5K8"/>
    <dbReference type="STRING" id="227321.Q5B5K8"/>
    <dbReference type="GeneID" id="2873596"/>
    <dbReference type="KEGG" id="ani:ANIA_04172"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN4172"/>
    <dbReference type="eggNOG" id="ENOG502RNRV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065198_0_0_1"/>
    <dbReference type="InParanoid" id="Q5B5K8"/>
    <dbReference type="OMA" id="FLPYWAR"/>
    <dbReference type="OrthoDB" id="4525340at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.30">
        <property type="entry name" value="Dynein light chain 2a, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="272"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF74558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="378" mass="40468" checksum="B2CF1636F6CD2201" modified="2005-04-26" version="1">MAEFKHPVHTGFSKPGGFADPHHRPYWARSQVKYAQDLLDYSPDPIVYEHDDQDYWDNHFFFPEDCLWSPPKDWVLDEEDDDDNSEEDIVAGECYDHDDTMIPGLPDIKMLDAEALSDLLEDNLSPPEITSILVFATNGAIFAYASPLPSRQLRNLSATYGAAYTCYAKNASSGNLTGVNPASHPSSYVTAQSVSLGDVGSIVFELDDLVAVVTKIADKVLLAAVGPSKLADAAPENQTLANSKPDSPKSAAYSHTESAQGPGTASGTGNNSTISTAASTPQTQSAASANMNGTSPYTNNTSSSASTVTPTAAPAGGYMTEAQLESQYEVDRSRDLERLASLNLSTPPSILLALESKSAALGRFLSQKLEDLESPEDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="112" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B5P6</accession>
    <accession>C8V4Z6</accession>
    <name>Q5B5P6_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Response regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ANIA_04134</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF74630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_661738.1">
        <property type="nucleotide sequence ID" value="XM_656646.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B5P6"/>
    <dbReference type="STRING" id="227321.Q5B5P6"/>
    <dbReference type="GeneID" id="2873550"/>
    <dbReference type="KEGG" id="ani:ANIA_04134"/>
    <dbReference type="eggNOG" id="KOG0519">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_69_12_1"/>
    <dbReference type="InParanoid" id="Q5B5P6"/>
    <dbReference type="OMA" id="HAWNGQE"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339:SF1">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="3"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="3">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBF74630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="171" mass="19486" checksum="A292216CECEA2A7E" modified="2005-04-26" version="1">MMHILVAEDNKVNQKLVTRLLQRLSCTVSIAHNGQEALDYLSASPATHHRPDVILMDTAMPVMDGIRATSILRTSLPFTVDPKIPTTPIIAMTPISLRVPGQTEEWLKRGFDDVLPKPFRLETLRMMLLYWSKRRIFPRQGTLSAPETGKVVPIPYGFLLRKGLEREWDRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B655</accession>
    <accession>C8V5X1</accession>
    <name>Q5B655_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ANIA_03975</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF74969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_661579.1">
        <property type="nucleotide sequence ID" value="XM_656487.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B655"/>
    <dbReference type="GeneID" id="2873398"/>
    <dbReference type="KEGG" id="ani:ANIA_03975"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN3975"/>
    <dbReference type="eggNOG" id="ENOG502SIYH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010595_9_5_1"/>
    <dbReference type="InParanoid" id="Q5B655"/>
    <dbReference type="OMA" id="WIAPARN"/>
    <dbReference type="OrthoDB" id="417697at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF74969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="300" mass="33219" checksum="B3A8B9A0C4831897" modified="2005-04-26" version="1">MSAASSNAEAQDASKYWVAPARNFRTSARLHLQHFLFQNTIGFLLEPAVGKAVTASSQPLKIADLACGNGVWLTELHSQLAKNNISVQLDGFDINPVNFPNPAFLPASVSFRQLDIFAKPLPAELLGVYDIVHIRAFGSIILDSNLAPILTAAFELLKPGGFIQWEETRGDRWIVESPSAQVSTTACDSIVQILLGGMQQRGIQNDWIDALDTHLNQFGFQNARLLVQEKRKHDFKGWTEDYLMVWEELADYFPSKAQAPDVSFSREAWISLFANAVKETEEGVVVHQGRVITAVGQKPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="103" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B6E0</accession>
    <accession>C8V6B8</accession>
    <name>Q5B6E0_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">DNA repair protein Rad4, putative (AFU_orthologue AFUA_2G04860)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ANIA_03890</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the XPC family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF75160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_661494.1">
        <property type="nucleotide sequence ID" value="XM_656402.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B6E0"/>
    <dbReference type="FunCoup" id="Q5B6E0">
        <property type="interactions" value="123"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5B6E0"/>
    <dbReference type="GeneID" id="2873313"/>
    <dbReference type="KEGG" id="ani:ANIA_03890"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN3890"/>
    <dbReference type="eggNOG" id="KOG2179">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003639_1_1_1"/>
    <dbReference type="InParanoid" id="Q5B6E0"/>
    <dbReference type="OMA" id="IPEWLMS"/>
    <dbReference type="OrthoDB" id="300780at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000111">
        <property type="term" value="C:nucleotide-excision repair factor 2 complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071942">
        <property type="term" value="C:XPC complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2460:FF:000001">
        <property type="entry name" value="DNA repair protein Rad4 family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.20.110:FF:000003">
        <property type="entry name" value="Putative DNA repair protein Rad4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.20.110">
        <property type="entry name" value="Rad4, beta-hairpin domain BHD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.290">
        <property type="entry name" value="Rad4, beta-hairpin domain BHD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2460">
        <property type="entry name" value="Rad4, beta-hairpin domain BHD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.260.10">
        <property type="entry name" value="Transglutaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018327">
        <property type="entry name" value="BHD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004583">
        <property type="entry name" value="DNA_repair_Rad4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018325">
        <property type="entry name" value="Rad4/PNGase_transGLS-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018326">
        <property type="entry name" value="Rad4_beta-hairpin_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018328">
        <property type="entry name" value="Rad4_beta-hairpin_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042488">
        <property type="entry name" value="Rad4_BHD3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036985">
        <property type="entry name" value="Transglutaminase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12135:SF0">
        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-C CELLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12135">
        <property type="entry name" value="DNA REPAIR PROTEIN XP-C / RAD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10403">
        <property type="entry name" value="BHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10404">
        <property type="entry name" value="BHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10405">
        <property type="entry name" value="BHD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03835">
        <property type="entry name" value="Rad4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01030">
        <property type="entry name" value="BHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01031">
        <property type="entry name" value="BHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01032">
        <property type="entry name" value="BHD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad4 beta-hairpin" evidence="8">
        <location>
            <begin position="479"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="domain" description="Rad4 beta-hairpin" evidence="9">
        <location>
            <begin position="540"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="domain" description="Rad4 beta-hairpin" evidence="10">
        <location>
            <begin position="602"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="298"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="723"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="806"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="889"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="662"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="22"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="348"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="889"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="904"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="924"/>
            <end position="944"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CBF75160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="951" mass="106218" checksum="E2E4CC3D5CB03568" modified="2005-04-26" version="1">MSSRTRPGRLASRGTPRSRRSKQAEDEIPEVYREMLAEAEAQEISQSENERPAKRFKPAGYRARTAQAFKAQVLQQDTNPMDAEEDAVKQPQIVYNSPSESDESDMEWEEVDIQQPTISGPTSSVTDEAPLQITLEQDHNRKRRVVRRKPVTAAEKKLRLDVHKMHLLCLMCHVQRRNLWCNDEEVQLNPPEEKPQHTRSAMFLDGLNQAGDIFFRRFKITRPGLRRAHWANDPDSLKRRTEAIISDAEVFLSLDDFRAQAKTMQGSRDFGAQLFCALLRSVAVEARLVCSLQPLPFSGAMQPPQKPEPEPIVISSDDPDSLTDGSTKSEAKPAPIRRIGRPGFKPTGVQNTTVLSSRPTRSESSYPVFWVEAFNEAFQKWVVIDPMVTKTLAKPHKLEPPATDPYNLLSYVVAFEEDASARDVTRRYTRVFNAKTRKLRVESTKNGEAWWKRVLEHFEKPFLEDRDELEIAELTAKTASEPMPRNVQDFKDHPIYALERHLRRNEVIFPKRVTGHVSLGKSGGKGQTEPIYRRSDVHILRSANKWYRLGRDIKVGEQPLKRIPVRNRGMAVDDEEEGEETALYAFFQTELYKPPPVVQGRIPKNAFGNLDVYVPSMVPAGGIHITHLDAARAARILGIDYADAVTGFSFKGRHGTAIIKGVVVASEYKEAVEEVLKALEEEKLQNEQEERAVEVLRAWKNLLMKLRIAERVKGYVIEGEADDEASGMEQGEPQGAGGFLPESDAETVTPQPNPRPPKEHSAYDGEVGGGFLPDFSAEGHSLVGELRRYRTSHGDQRDQLVSASLSDLGGGFVPEGDGLNPTVREPPRRVKSPPLRYDLIVVPNNADIPPAERHSTIGQPQNANPAQALSAVTRALGGSIDEPITVASSVNDSASASVEILSRAPSQVQSRAQSVEVASQASEHEDEENEGSLLSEDPEDEDAVPEWLMSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B6M7</accession>
    <accession>C8V6T8</accession>
    <name>Q5B6M7_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Mitochondrial import receptor subunit (Tom37), putative (AFU_orthologue AFUA_2G03840)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ANIA_03803</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF75348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_661407.1">
        <property type="nucleotide sequence ID" value="XM_656315.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B6M7"/>
    <dbReference type="STRING" id="227321.Q5B6M7"/>
    <dbReference type="GeneID" id="2873224"/>
    <dbReference type="KEGG" id="ani:ANIA_03803"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN3803"/>
    <dbReference type="eggNOG" id="KOG3028">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032751_0_0_1"/>
    <dbReference type="InParanoid" id="Q5B6M7"/>
    <dbReference type="OMA" id="GYMVHVG"/>
    <dbReference type="OrthoDB" id="5835136at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001401">
        <property type="term" value="C:SAM complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03078">
        <property type="entry name" value="GST_N_Metaxin1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033468">
        <property type="entry name" value="Metaxin_GST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050931">
        <property type="entry name" value="Mito_Protein_Transport_Metaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019564">
        <property type="entry name" value="Sam37/metaxin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12289:SF41">
        <property type="entry name" value="FAILED AXON CONNECTIONS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12289">
        <property type="entry name" value="METAXIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17171">
        <property type="entry name" value="GST_C_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10568">
        <property type="entry name" value="Tom37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Mitochondrial outer membrane transport complex Sam37/metaxin N-terminal" evidence="7">
        <location>
            <begin position="21"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Metaxin glutathione S-transferase" evidence="8">
        <location>
            <begin position="221"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBF75348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="421" mass="46246" checksum="8ECD8DA6E13DE671" modified="2005-04-26" version="1">MVLELHIWGPGFSLPSIDAQCLATIAYFSLAVPKDSWVLVASSDPTVSPTHELPALKNGSTWVSRFRNIVDYLRQYSNGAWDLDRDLSALEKADSVAFSSFVESHAQALLDLSLYVTSQNYYNSTSPAYGAILQWPNQWILPPQLHATAKARTEPLGLSSLDLEATEEQRKRDHSAAVAAGRIPQNLISRPRETVTNLLGKTPQQHQFRLEALTGELFVPLEELLDDKTHLLGTTPSSLDCLSVGYLSLALVPDLPLPWLRDAMQRKAPRLSQYIERLRLELFGTVNVADAFNSGANSLLPWQAPERASFARVGTSLLTSLADSTPILKEIRMNNKLRETAECSSAGLSEVESKSLSEYARAQGKDTLLSIATVIGGVAALIGYMAHIGVFSAPQEEEKEEPEEYQVELPKSISANDFLGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="109" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B6P6</accession>
    <accession>C8V709</accession>
    <name>Q5B6P6_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA repair protein RAD14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">ANIA_03784</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the XPA family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF75392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_661388.1">
        <property type="nucleotide sequence ID" value="XM_656296.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B6P6"/>
    <dbReference type="FunCoup" id="Q5B6P6">
        <property type="interactions" value="86"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5B6P6"/>
    <dbReference type="GeneID" id="2873204"/>
    <dbReference type="KEGG" id="ani:ANIA_03784"/>
    <dbReference type="eggNOG" id="KOG4017">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053731_0_1_1"/>
    <dbReference type="InParanoid" id="Q5B6P6"/>
    <dbReference type="OMA" id="HISATEW"/>
    <dbReference type="OrthoDB" id="5368863at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000110">
        <property type="term" value="C:nucleotide-excision repair factor 1 complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901255">
        <property type="term" value="P:nucleotide-excision repair involved in interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000715">
        <property type="term" value="P:nucleotide-excision repair, DNA damage recognition"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070914">
        <property type="term" value="P:UV-damage excision repair"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd21077">
        <property type="entry name" value="DBD_Rad14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.530.10:FF:000003">
        <property type="entry name" value="Dna repair rad14 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.530.10">
        <property type="entry name" value="XPA C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000465">
        <property type="entry name" value="XPA/RAD14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022656">
        <property type="entry name" value="XPA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022658">
        <property type="entry name" value="XPA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037129">
        <property type="entry name" value="XPA_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00598">
        <property type="entry name" value="rad14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10142">
        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-A CELLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10142:SF0">
        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-A CELLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05181">
        <property type="entry name" value="XPA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="Putative DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00753">
        <property type="entry name" value="XPA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="XPA C-terminal" evidence="12">
        <location>
            <begin position="154"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="21"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="73"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00072989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF05181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CBF75392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="309" mass="35726" checksum="DFCB22B18C344287" modified="2005-04-26" version="1">MASDSQSTPPPSTGTLARGELTPEQRKRIQKRSENSANPSSAPPPLSQQKAKMTDTKGGFLAEEDDPFNKALHVKDGKDEKPANMTQKEWERQQLLKNLRRDRAGPFEPGISVLDEKSEQKVCRECGSLEIDWRWEEELRCRVCHACKDKFPEKYSLLTKTEAKEDYLLTDPELRDTELLPHIEKPNPHKSTWNNMMLYLRYQVEEYAFSDKKWGSPEALDAEFEKRENDKKRRREEKFKTKLDDLKKRTRVEAYRRNRKGAAGGNFGDEIGRGGRHVHQWGRSILDPETGIGTKKCVDCGMEVEELEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="103" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B893</accession>
    <accession>C8VI68</accession>
    <name>Q5B893_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ANIA_03237</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF83124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_660841.1">
        <property type="nucleotide sequence ID" value="XM_655749.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B893"/>
    <dbReference type="GeneID" id="2874416"/>
    <dbReference type="KEGG" id="ani:ANIA_03237"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_25_3_1"/>
    <dbReference type="InParanoid" id="Q5B893"/>
    <dbReference type="OMA" id="FWVLEAV"/>
    <dbReference type="OrthoDB" id="4161376at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010573">
        <property type="entry name" value="MFS_Str1/Tri12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF109">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06609">
        <property type="entry name" value="TRI12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="58"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="126"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="209"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="252"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="285"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="323"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="365"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="391"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="420"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="552"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="59"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="24"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBF83124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="586" mass="63741" checksum="EC181BA98D237EE3" modified="2005-04-26" version="1">MASDESKETHVQYGSEEGSIDRTQTADDGERSQIFDSDSQHPKVPRLLYDFRLENTRLIMVLVGFGMSFVGSQIQPLLFAPIFPLVSSSFNASNLLFWFTCTQQIATGVVAPFSGSLADLFGRKSITLAGILSAMVGMILCAASPSAGGYLAGQVFNGFGIAVQELMAIAAIAEIVPTRYRGYYIAAVVASFLPFAPGSLYGALIAQHNWRYCACMVAIWNLLTAGMIWWFYNPPPRTNTAGLSKIEKVKRIDSIGGLIMTAGLVFLLISLNWGGQQYPWNEAKVIAFLTLGIALLILFFVYEKFFAAYPMFPSTLLRHPRTFTALMVVILLAGINYVALLVFWVLEAVSVFDSSQFELGVRTMPYGFCIVGGAIISAILISAFKGHLRLIMTGFCVVQVTPLTQAGIGCMAAIRTSDISTVWAPLIFSLLGIGGVLVPNQIIVTIICPDDLLATATCLTACLRAVGQVIGTSIFFNQFTSALVANTYSHVVPAAIEAKFYQFNMIAPMMETLVTTPWKEWVVTVKDTITPEQATILHTAVVEAFRLAFERVWYISIGFGVAAVLASVLIEDLGALMDGHIAVKYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B8H2</accession>
    <accession>C8VIF6</accession>
    <name>Q5B8H2_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F-box domain protein (AFU_orthologue AFUA_3G13460)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_03158</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF83289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_660762.1">
        <property type="nucleotide sequence ID" value="XM_655670.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B8H2"/>
    <dbReference type="GeneID" id="2873859"/>
    <dbReference type="KEGG" id="ani:ANIA_03158"/>
    <dbReference type="eggNOG" id="ENOG502S4JF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_364471_0_0_1"/>
    <dbReference type="InParanoid" id="Q5B8H2"/>
    <dbReference type="OMA" id="IHNRRKA"/>
    <dbReference type="OrthoDB" id="8864979at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025204">
        <property type="entry name" value="CENP-L"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13092">
        <property type="entry name" value="CENP-L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="508"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="720"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="520"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="720"/>
            <end position="735"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF83289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="766" mass="85300" checksum="44E9A3E9F9F9A4B7" modified="2005-04-26" version="1">MSIMLTLTMGSVPPPLGIGCFRLLPRSLHFLTLKLVCKAFNEVLSKHEHPIARRYLRQRRHGTLPSPIDTQRTYTWKPEDDVVLLSDLFPPTISAKGGFLYTFRYLHSLRRRQKLCSRLCYYLADRIVNKFVACEGMFMKTTFASKAERAVFMRRAMGKVWSYLSPLMYYTLYFLESYADARREQTNVLLRDFEAGRLPVRIPPDIRKRMYQELQRKIMQSPPFTDTTTLISTHHCLRLLVSWLRDTVPPDEQDVSDDSWIGSLLTVSPFQRLVEYFSAEIGDGGNQRMQRKDFMYNFHRDISLTENDEMNSRVFESAPNVHLHRSVQDVWFDAATAEIAKRRAGNHRKEKVMLYDGVPFLFGCPYCKPGAGDGCPYHLLNTSWTSHRLSPLHYEINKNAESYSLLTNRTALDTYAARLRDYLTNSLAVAGAPTLQHDPATSATLGALQSCTWEAISSLSFLDASMISEHGGHSAFEQNEEEPAGLLITLTYENATYKAALLSSGAVSRNQSQDQEQLQKQRKRKRGRPSLKSSITTVSASTHLPLLLLRLPKPLRESLFSFLSSNFDTYVSALRISSHGLCEILQSYLSGLTPAGPVNAGADVGEIMRELHITISFAPPIAPSLKALTVCIPRETSGAFIRVPGSTSYAGNAGTSVLSGLSAYLSKHLALDLRLPLVEGAAATTAGSLLTGGYVRLTRIACAGFVVTSEGRLKIVAKAEDRTGGEEDDEQKRGELSGGEALLRAVLKRAGNGMGSGFDSHAEEQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BA11</accession>
    <accession>C8VHT0</accession>
    <name>Q5BA11_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6594 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ANIA_02619</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF84353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_660223.1">
        <property type="nucleotide sequence ID" value="XM_655131.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BA11"/>
    <dbReference type="GeneID" id="2874102"/>
    <dbReference type="KEGG" id="ani:ANIA_02619"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN2619"/>
    <dbReference type="eggNOG" id="ENOG502SQ2Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051118_2_2_1"/>
    <dbReference type="InParanoid" id="Q5BA11"/>
    <dbReference type="OMA" id="MFFETAA"/>
    <dbReference type="OrthoDB" id="3533814at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046529">
        <property type="entry name" value="DUF6594"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34502:SF5">
        <property type="entry name" value="DUF6594 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34502">
        <property type="entry name" value="DUF6594 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20237">
        <property type="entry name" value="DUF6594"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="256"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="282"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6594" evidence="3">
        <location>
            <begin position="55"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBF84353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="314" mass="35704" checksum="906EFAA4E47996EA" modified="2005-04-26" version="1">MAQIHTVDNTTSPYSYPLKQIPAKSTCMPIPMPAPDLPTESPSPSPSSKPRNPGYSDLASLMYKDKGLSIFRSFRHLNAKNLLYYQAEIVNAEAELQEIIEDDATSGDTDREKFASSVRYLKDSQFPPSEQWKKFIELRGLLEAYNAAVLQYASILQLAAPHENDRELLRSWLREWAFCKTGAEFDQWFGERDENADDLVTLLGRYENVDHFTKWVIQSVIPAFHEWVGWRRTNDRDIEMGIVTYDDKKVKRATRIASTITSSVIPASSMIALYLIKNMITRLIIIIIYNIAFSVILGLLAKARRVEVFAASTA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2023-02-22" modified="2025-02-05" version="103" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BA93</accession>
    <accession>C8VPM0</accession>
    <name>PLYL_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pectate lyase PEL9</fullName>
            <ecNumber evidence="5">4.2.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">AnPL9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">PEL9</name>
        <name evidence="6" type="synonym">PL9</name>
        <name evidence="9" type="ORF">ANIA_02537</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="journal article" date="2022" name="Appl. Biochem. Biotechnol." volume="0" first="0" last="0">
            <title>Biochemical Characterization of a Pectate Lyase AnPL9 from Aspergillus nidulans.</title>
            <authorList>
                <person name="Suzuki H."/>
                <person name="Morishima T."/>
                <person name="Handa A."/>
                <person name="Tsukagoshi H."/>
                <person name="Kato M."/>
                <person name="Shimizu M."/>
            </authorList>
            <dbReference type="PubMed" id="35802235"/>
            <dbReference type="DOI" id="10.1007/s12010-022-04036-x"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>COFACTOR</scope>
        <scope>ACTIVITY REGULATION</scope>
        <scope>BIOPHYSICOCHEMICAL PROPERTIES</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>INDUCTION</scope>
        <source>
            <strain evidence="6">A26</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Presents an endo-cleaving activity on the homogalacturonan (HG) region in pectin (PubMed:35802235). Active on homogalacturonan with a degree of polymerization above 4, and does not appear to be affected by the degree of methylation of the substrate (PubMed:35802235). Does not degrade linear rhamnogalacturonan (PubMed:35802235).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>Eliminative cleavage of (1-&gt;4)-alpha-D-galacturonan to give oligosaccharides with 4-deoxy-alpha-D-galact-4-enuronosyl groups at their non-reducing ends.</text>
            <dbReference type="EC" id="4.2.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="5">Inhibited by iron ions (PubMed:35802235). Activated in presence of the surfactant polysorbate 20, while inhibited in the presence of Triton X-100 and sodium dodecyl sulfate (PubMed:35802235). Inhibited in presence of the organic solvents methanol, ethanol, propan-2-ol and acetone (PubMed:35802235).</text>
    </comment>
    <comment type="biophysicochemical properties">
        <kinetics>
            <text evidence="5">kcat is 280 sec(-1) for homogalacturonan (HG) (at 45 degrees Celsius and at pH 8) (PubMed:35802235). kcat is 357 sec(-1) for apple pectin (at 45 degrees Celsius and at pH 8) (PubMed:35802235). kcat is 272 sec(-1) for citrus peel pectin (at 45 degrees Celsius and at pH 8) (PubMed:35802235). kcat is 236 sec(-1) for rhamnogalacturonan type I (at 45 degrees Celsius and at pH 8) (PubMed:35802235).</text>
        </kinetics>
        <phDependence>
            <text evidence="5">Optimum pH is 8.</text>
        </phDependence>
        <temperatureDependence>
            <text evidence="5">Optimum temperature is 45 degrees Celsius.</text>
        </temperatureDependence>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="5">Induced during growth on homogalacturonan (HG).</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the polysaccharide lyase 9 family.</text>
    </comment>
    <dbReference type="EC" id="4.2.2.2" evidence="5"/>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF87052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_660141.1">
        <property type="nucleotide sequence ID" value="XM_655049.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BA93"/>
    <dbReference type="SMR" id="Q5BA93"/>
    <dbReference type="STRING" id="227321.Q5BA93"/>
    <dbReference type="CAZy" id="PL9">
        <property type="family name" value="Polysaccharide Lyase Family 9"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CBF87052">
        <property type="protein sequence ID" value="CBF87052"/>
        <property type="gene ID" value="ANIA_02537"/>
    </dbReference>
    <dbReference type="GeneID" id="2874771"/>
    <dbReference type="KEGG" id="ani:ANIA_02537"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN2537"/>
    <dbReference type="eggNOG" id="ENOG502QSUT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030634_1_0_1"/>
    <dbReference type="InParanoid" id="Q5BA93"/>
    <dbReference type="OMA" id="DSHHNYD"/>
    <dbReference type="OrthoDB" id="5561043at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016837">
        <property type="term" value="F:carbon-oxygen lyase activity, acting on polysaccharides"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030570">
        <property type="term" value="F:pectate lyase activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052009">
        <property type="term" value="P:symbiont-mediated disruption of host cell wall"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053868">
        <property type="entry name" value="Pel9A-like_beta_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052052">
        <property type="entry name" value="Polysaccharide_Lyase_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40088">
        <property type="entry name" value="PECTATE LYASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40088:SF1">
        <property type="entry name" value="PECTATE LYASE PEL9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22842">
        <property type="entry name" value="Pel9A-like_beta_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0106">Calcium</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010168540" description="Pectate lyase PEL9" evidence="2">
        <location>
            <begin position="19"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="342"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="381"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="342"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="271"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P0C1A7"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="35802235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="6">
        <source>
            <dbReference type="PubMed" id="35802235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="7"/>
    <evidence type="ECO:0000305" key="8">
        <source>
            <dbReference type="PubMed" id="35802235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="9">
        <source>
            <dbReference type="EMBL" id="CBF87052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CBF87052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="410" mass="43891" checksum="1BF619F86AB51CE6" modified="2005-04-26" version="1" precursor="true">MMGKSVWVFAALFPAVLAADIYVSPDGSDDAAGTIDAPLQSIQLAVDQATAGSTIYLRGGTYTPTSNIQITKSGTASAPYVLRAYEGESVIIDGEELPGTPADLDASLDNADRGILHIQDAEYWEFYDLELINGPYGVYARDASNNHYERITTRNNYETGFQLQGESSNNVVLYLDSYGNRDPRKNGESADGFACKEGSGEGNILRGARLWNNVDDGLDLWYAVNPVHPRISANTSREFKSAVTIEDTIAWGNGFNRWDFTPFEGDGNGFKLGGGDDTDIGPADHIITNCIAFSNAKDGFTDNSQPGNFVLTRNTAWDNTAVGFKFGTAVATLTGNIAASNGEAPTSLSDEQISDGNSWDGDEDWDDGSFVSVDVSLVQGERNADGTIEPSGFLLPADGEEIGATTDWSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BBJ7</accession>
    <accession>C8VLR0</accession>
    <name>Q5BBJ7_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_02083</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF86142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_659687.1">
        <property type="nucleotide sequence ID" value="XM_654595.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BBJ7"/>
    <dbReference type="GeneID" id="2875728"/>
    <dbReference type="KEGG" id="ani:ANIA_02083"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN2083"/>
    <dbReference type="eggNOG" id="ENOG502T3TM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_422738_0_0_1"/>
    <dbReference type="InParanoid" id="Q5BBJ7"/>
    <dbReference type="OMA" id="FWMGSQD"/>
    <dbReference type="OrthoDB" id="73788at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="434"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="498"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="42"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="378"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="402"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="509"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF86142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="648" mass="70744" checksum="A31E3F55F6E7A101" modified="2005-04-26" version="1">MGRGDNDRISRSNPDRFRTPDKPASSSKLARVPARLGVGSLAVTPGASSTSTATSTPSTVSTSRSRSGGSKRNTALDQTTLTQIEFVKRSQPDYDDDVFKYIGGSGSNACEVIEIDDDEPDNANDKNYRPSGSRTKRENSIRLGSAPSRLKKKGSVQGDKISRNGRKKSGNDKGVQNDDNTLTQMKYVKLIDLESDDGDAKLEYAYLTSRKRDPELRAASTGKHDNTKQQQPTYVSEPPSGHKRRKLSSCSMKKEPCQMKEKLEEKVENLPSTPRKLLRTEIPSSQSPESPGVAFITSSQFRSAARSPERRPLIFSKETPVKEEPHSSLEKGDAAEIAQMPLNDKNQSVHYDSPQPSPLARRASAERTPKTTGREKSVAVADAPAAFDPRQRPAQRTVVYETDAESDYDEYEDGMQDISSSSKDTNIAVYEAPVENEPNSPIIESQELPPQPVSVKEPEYGPFSSESTLLSEASICYRRVHPNTQFPLEPVPTINTQKLAELFPEESNGLRSITPTPSSSPMKAPLTSNAPIMVSETQSLDQTLPDSEDGSRTPTDIVPESSPAARHEDSVPLNGHGPSARNVVVQVESSQPVDRAGRPRTAGQDSAPRAMLSRSQILTSSVMESIPIPGFWMSSQDSVGEPYNQPDS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-22" modified="2026-01-28" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BBM5</accession>
    <accession>C8VLN1</accession>
    <name>MDM34_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mitochondrial distribution and morphology protein 34</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">mdm34</name>
        <name type="ORF">AN2055</name>
    </gene>
    <organism>
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. Mdm34 is required for the interaction of the ER-resident membrane protein mmm1 and the outer mitochondrial membrane-resident beta-barrel protein mdm10.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the ER-mitochondria encounter structure (ERMES) or MDM complex, composed of mmm1, mdm10, mdm12 and mdm34.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <text evidence="1">The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria-endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids.</text>
    </comment>
    <comment type="domain">
        <text evidence="1">Lacks alpha-helical transmembrane segments, suggesting that it resides in the membrane via beta-sheet conformations similar to those predicted for other outer membrane proteins and porin.</text>
    </comment>
    <comment type="domain">
        <text evidence="1">The SMP-LTD domain is a barrel-like domain that can bind various types of glycerophospholipids in its interior and mediate their transfer between two adjacent bilayers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MDM34 family.</text>
    </comment>
    <dbReference type="EMBL" id="AACD01000032">
        <property type="protein sequence ID" value="EAA64887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF86089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_659659.1">
        <property type="nucleotide sequence ID" value="XM_654567.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BBM5"/>
    <dbReference type="SMR" id="Q5BBM5"/>
    <dbReference type="STRING" id="227321.Q5BBM5"/>
    <dbReference type="EnsemblFungi" id="CBF86089">
        <property type="protein sequence ID" value="CBF86089"/>
        <property type="gene ID" value="ANIA_02055"/>
    </dbReference>
    <dbReference type="KEGG" id="ani:ANIA_02055"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN2055"/>
    <dbReference type="eggNOG" id="ENOG502QT3W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036502_1_0_1"/>
    <dbReference type="InParanoid" id="Q5BBM5"/>
    <dbReference type="OMA" id="VFRAWSG"/>
    <dbReference type="OrthoDB" id="17927at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032865">
        <property type="term" value="C:ERMES complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990456">
        <property type="term" value="P:mitochondrion-endoplasmic reticulum membrane tethering"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015914">
        <property type="term" value="P:phospholipid transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd21673">
        <property type="entry name" value="SMP_Mdm34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03105">
        <property type="entry name" value="Mdm34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027536">
        <property type="entry name" value="MDM34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058825">
        <property type="entry name" value="MDM34_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031468">
        <property type="entry name" value="SMP_LBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28185">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28185:SF1">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26545">
        <property type="entry name" value="Mdm34_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51847">
        <property type="entry name" value="SMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0445">Lipid transport</keyword>
    <keyword id="KW-0446">Lipid-binding</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1134">Transmembrane beta strand</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000384342" description="Mitochondrial distribution and morphology protein 34">
        <location>
            <begin position="1"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="domain" description="SMP-LTD" evidence="1">
        <location>
            <begin position="1"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="208"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="299"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="531"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="314"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="332"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="359"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="370"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="386"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="561" mass="61417" checksum="102C368490F9A910" modified="2005-04-26" version="1">MAFNFNWSPLTADANFYTRAQDLLTAALNKSPKPPIIVDDIIVTELNLGSIPPELEILEVGDLAEDRFRGIFKMSYSGDAFLTLKTRVQANPLNTYLLTRPSFASPLPLAAATPLTIPLQITLSDFKLSGFVVLVFSKQKGITVVFRNDPLESLKVSSTFDSIPFVRDFLQKEIEAQLRILFMDELPAIIHRLSLRLWVPEYRDGEQLETQDTASRTEGPGQDPLASPPQDPVDALGNALNESDIASLSLESSVETHSLFSQKNLLRLAALTDSQRTLSLFTPSIREVVYRAWTSPTDSGEATAGVISPASPALSRTHSQVGNISSFPDTASMVSSQTRSTTSTHSFSSYGLNTGSSRSKVHSRKRKKRVVDLRRPKTTDDAASVSDESAFTESTSAPSVYSAPLPIVREQPDDPVTPPLSPETGLHLPPVPERHRLSTSRPGIRRGADAFVQSGESSSSARRRSDVDVDATPRGTMRSHVAMTRCSEKPEPEAPQQLPSTILPFADEKASSNLVDQALVERLAGEIARRMRDEKMPGSSTCTPFWDRLNHDEAPPPAYGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="109" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BBM6</accession>
    <accession>C8VLN0</accession>
    <name>Q5BBM6_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ANIA_02054</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF86087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_659658.1">
        <property type="nucleotide sequence ID" value="XM_654566.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BBM6"/>
    <dbReference type="STRING" id="227321.Q5BBM6"/>
    <dbReference type="GeneID" id="2875774"/>
    <dbReference type="KEGG" id="ani:ANIA_02054"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN2054"/>
    <dbReference type="eggNOG" id="KOG2464">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029053_0_0_1"/>
    <dbReference type="InParanoid" id="Q5BBM6"/>
    <dbReference type="OMA" id="DMCCAAD"/>
    <dbReference type="OrthoDB" id="5327538at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072354">
        <property type="term" value="F:histone H3T3 kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000961">
        <property type="entry name" value="Putative serine/threonine-protein kinase haspin homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024604">
        <property type="entry name" value="GSG2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24419">
        <property type="entry name" value="INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24419:SF18">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE HASPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12330">
        <property type="entry name" value="Haspin_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01331">
        <property type="entry name" value="DUF3635"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Serine/threonine-protein kinase haspin C-terminal" evidence="10">
        <location>
            <begin position="471"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="541"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CBF86087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="642" mass="72384" checksum="E5ACADCA493B758A" modified="2005-04-26" version="1">MESVRPLYIKDTPPPRNTGASSTRAPGKRKVYGKRRTDAPRAVFEQRSPAKTLDVADSDAVQNAVNLLQAKLADFKIDETKITKKVQEVSKQKDIHKAAGAGLCKSTANETPISNPESLGDTVPAQQPVLKATPRRKKKYQTMVEVRVTPRVIPKDPQIPPTLDSCKRSTRKIKPLQRPSFEYISDEKATSYVRSILDQTLSPAAAQGIQKFDSWAARAGEMLEVVKLAEGSYGEVYKLRLREDICQKEMSSSRLARLRACGNGVFKVVPLRAQSGPGSKKFTSIEEIVAEVKMLKYLDPIPGFARFREVHVVQGRFPEAFQKAWDHYRKTKDDCLNPNPSSKRAYPDSQIWAIIEMDDAGCELEKFSWSSIFQVYDIFWGVAMSLARAEEYALFEHRDLHLGNICIRSTRPDGLMHPPSDSEIICQAYSSGFGLSTLQTTLIDYSLSRAELVVDETSETLEVTSSDLDKKQIFDAIGQDEDDALLRDTYRHMRAQLYKGNPIDTEKTPDIPGIWAEYAPRTNLIWLRFLLKMLLKNRKHETSEPPSQNQRQPLAPCSPNKKIKKGAKSDKKKQDAINGLQLASDAHSQIVQLKRILEERLLAVLELLDLEHGHEDMCCSADLVAFAIDAQWLDERDFFFAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="102" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BBP2</accession>
    <accession>C8VLG7</accession>
    <name>Q5BBP2_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Amine oxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_02038</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF86059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_659642.1">
        <property type="nucleotide sequence ID" value="XM_654550.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BBP2"/>
    <dbReference type="GeneID" id="2875066"/>
    <dbReference type="KEGG" id="ani:ANIA_02038"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN2038"/>
    <dbReference type="eggNOG" id="ENOG502SMFE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028280_0_0_1"/>
    <dbReference type="InParanoid" id="Q5BBP2"/>
    <dbReference type="OMA" id="YGHYYAG"/>
    <dbReference type="OrthoDB" id="68575at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0000270"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1990:FF:000001">
        <property type="entry name" value="Amine oxidase, flavin-containing superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.405.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030175802" description="Amine oxidase domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF86059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="463" mass="50678" checksum="B577DF811D336EFF" modified="2005-04-26" version="1">MLTAFLFVAGALVACVRPQQFDPSAYAAEDVIERDFAIIGGGAAGTYAAISLADQNKTFTVVEMTGRLGGHTRTFRDEATGASIDIGVQLHENIPIVRDFFKRLNSPLAAFKPTDFGNPKYYDFTKKVALPNHTRPTIESDYVAVLNKYPFLDDLNNLPDNVPEELLLTWPDFAEKQNLSAASTEAGLLWPATPGNPLDTTALAIFNDGNHIELAEYAGAAVRSAAHYNSQIYDNALAELKEHVLLKSSIIAAQRGSSRKDGVRLIAETPSGRKLIKAKQLIIAMPPVLDNVKYFALDQQEHSILSKLSGKHYYAGVVNNTGLEAGVAYTNVGQNTPYHVASLPGVVEIAGSASPGYFFYWYNSVDPQTQAEIEEATRCTIKWLQSESGTEAVEPTFQDFADYSPFHLSPSTSDVADGWYGKMKGLQGHRNTWYISSLFVVGSTQVWNNTRNILPEIIDAARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="151" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BBR9</accession>
    <accession>C8VLD9</accession>
    <name>Q5BBR9_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Phospholipid-transporting ATPase</fullName>
            <ecNumber evidence="16">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">ANIA_02011</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="21">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11 16">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66132"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:66133"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Membrane</location>
            <topology evidence="1 16">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="16"/>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF86008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_659615.1">
        <property type="nucleotide sequence ID" value="XM_654523.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q5BBR9">
        <property type="interactions" value="24"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5BBR9"/>
    <dbReference type="GeneID" id="2874957"/>
    <dbReference type="KEGG" id="ani:ANIA_02011"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN2011"/>
    <dbReference type="eggNOG" id="KOG0206">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000846_5_0_1"/>
    <dbReference type="InParanoid" id="Q5BBR9"/>
    <dbReference type="OMA" id="GWFLWNI"/>
    <dbReference type="OrthoDB" id="377733at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140326">
        <property type="term" value="F:ATPase-coupled intramembrane lipid transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006892">
        <property type="term" value="P:post-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000159">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000172">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006539">
        <property type="entry name" value="P-type_ATPase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032631">
        <property type="entry name" value="P-type_ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01652">
        <property type="entry name" value="ATPase-Plipid"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF174">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE DNF3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16209">
        <property type="entry name" value="PhoLip_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 15 16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 14 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 16" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="592"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="634"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1360"/>
            <end position="1380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1410"/>
            <end position="1433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1445"/>
            <end position="1462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1474"/>
            <end position="1493"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1521"/>
            <end position="1541"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase N-terminal" evidence="18">
        <location>
            <begin position="318"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase C-terminal" evidence="19">
        <location>
            <begin position="1296"/>
            <end position="1551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="192"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="754"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="936"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1011"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1641"/>
            <end position="1669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="105"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="936"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1025"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="13">
        <location>
            <position position="701"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="701"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="701"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="702"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="703"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="703"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="842"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="890"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="913"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU362033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF16209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF16212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CBF86008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="1688" mass="188713" checksum="F18A9DF76454940D" modified="2005-04-26" version="1">MSQPNRVPDSTQNRSPQQPRISLDQPSSPSDTTSQIPRRPPQPSRSHSLRIAAPGRTSLSPSRTLSDSGRRLSQQHVRFSADLERPIAEGNTQASWEQDRRPSSRGLSINTSIANTQSLSSATSPDANRAPNSTLSPRSALSPTSPQSPDTVGRSRSRNRGYSLRRTIFAKNIESQSAPPSPVELGDIAKTESEVAEQEVSAAPAPGTSETKFSENEKLEVNVAQKSTSASACTENGLSVYSSEQTDLKEGRNLSPSLSYDRWLKRKAAITALQLRAENFLETIRKTILRIKTIPPSKDGRHIDLDPTRTENLIDERTGKPYVENWIRSSRYSLWSFFPRQFFAQFTKLANFYFLVVAILQMIPGLSTTGKFTTIVPLLIFVGISMGKEGFDDWRRYRLDKEENNRFAYVLRPGANVLSRSVTGDSGSTSSESQDWDMVKWNEIKVGDVIRLERDQPVPADMVLLHADGPNCTAYVETMALDGETNLKTKQPCHSVAKVCGTVGGICSSSIHFAVEDPNLDLYKFDGNVTVAAGEKTPLTNNEILYRGSILRNTERAVGMVIYTGEECKIRMNANKNPRIKMPSLQGKVNRVVMLIVLLVVMLAGACTIAYKYWSHDVESHAWYLEDANVSYGPVFTSFLIMFNTMIPISLYVSMEIVKVAQMLMLNADIDMYDPESDTPLEARTSTINEELGQVSYIFSDKTGTLTNNSMRFRKMSVAGTAWFHDFDLLDEAAQEGDREKLIHKKRSVKGKKAVARQSNVSEVQRSLARPSMSTHDGARKEGPSVPNTRTTDMLKYIQRKPYTVFARKAKMFILAMALCHTCLPEEDESGNTTFQAASPDELALVTAARELGYIVHDRQPNTLTVRTFPNGQDQEPVDEVYEILDVIEFSSARKRMSVVVRMPDRRICLFCKGADSVLMKLLKRAALAQEKVNEIERRASKRKAAEASEVIRRNSEHHNRKDSGVRNSFSRPSMSHRRSSVSGRRASTLRDSIDVWLRDRETDGGLLHRNSDVEYYSPRPSAQLGRQSTTFSDSGSSVHDDEEDLVEEALVVDEAAVFERCFQHLNDFATEGLRTLLYAHRFLDEATYAEWRCAYQEATTSLVNRQERIEQVGQQIEQQLELTGATAIEDKLQKGVPETIDKLRRANIKLWMLTGDKRETAINVGHSCRLVKDYSSLVILDQEMGNVEESISNLTKDILNKTVAHSVVVVDGQTLSMIEGDETLRAAFFKLAILVDSVICCRASPKQKAFLVKSIRRQVQDSVTLAIGDGANDIAMIQEAHVGIGITGKEGLQAARISDYSIAQFRFLLKLLLVHGRWNYMRACKYTLGTFWKEMLFYLTQALYQRWNGYTGTSLYEPWSLSMFNTLFTSLAVIFLGIFTKDLSASTLLAVPELYTKGQRSEGFNIRLYLGWTFIATCEAMLVYFVMYSLFGNVLFTTGNINDIFSAGLLTFSACVIIINTKLQVLEVHNKTYLSLAVFIISVGGWFLWNMILSRQYDFKSGDGIYHVPGNFLLHSGHDLSFWVVLLITVTAVIIFEIIVASLRANIFPTDVDVFQEYEKDLDIRKRFEEAAASELQQGWDHGKKKSSFEIAREEAEMEARERQVAELLARPRVMSDAAKNDSSRGVGVYVESASESASASASALGDSQDQIAGTGVGAESSAPRRSMEIHELFSKGFGALKKGQLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="129" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BC65</accession>
    <accession>C8VKG4</accession>
    <name>Q5BC65_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS sugar transporter, putative (AFU_orthologue AFUA_2G04550)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ANIA_01865</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF85717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_659469.1">
        <property type="nucleotide sequence ID" value="XM_654377.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BC65"/>
    <dbReference type="GeneID" id="2874751"/>
    <dbReference type="KEGG" id="ani:ANIA_01865"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN1865"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_12_1"/>
    <dbReference type="InParanoid" id="Q5BC65"/>
    <dbReference type="OMA" id="IIMTYAE"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000090">
        <property type="entry name" value="MFS sugar transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF4">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="108"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="263"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="302"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="330"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="367"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="436"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="13"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBF85717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="490" mass="53512" checksum="979112702C340725" modified="2005-04-26" version="1">MGRKLSLFRAIYLASASCMGSFAFAFDTGVISGVLTLESFQRDFRYTESQKTTVNSNAVSILQAGAFFGCFLTTPVASRFGRRSGLIISSLVFTVGTILQIINAHTLATFYTGRVIAGVGIGAATVLIPMYSAEMAPKEIRGRLGACFQLFFALGVMIAYWVTFAVSETQPPKPKQWQIALGLQLLPSTLLLIGMVTVKESARWLAVKGRNEEAWESLKWVRGGEDTPELQQEFDEILAGIAEEARVKENFTWRELLLPANRYRIFIAITIQLCAQLSGNTSLAYYATQIFSAVGAGSSAKLVTGFFGVVKVVGVSIFQLFVIDKIGRRVPFMAGAFAMGSFMLIIACVLATHPTSSDGADSGATPAGIAMIIMVYAEAFSFNMSWGALPWLYVGEIFSSRLREVGVTVGAASQWLFNFMMSQVTPHAISNIGWRMFLMFAIFNYAIVVYSWVFLKETLKVSLEEMQGIFGAGTEPDGKPTVEAHESLTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="141" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BC79</accession>
    <accession>C8VPR4</accession>
    <name>Q5BC79_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CCT-theta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ANIA_01851</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF85686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_659455.1">
        <property type="nucleotide sequence ID" value="XM_654363.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BC79"/>
    <dbReference type="FunCoup" id="Q5BC79">
        <property type="interactions" value="1491"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5BC79"/>
    <dbReference type="GeneID" id="2875556"/>
    <dbReference type="KEGG" id="ani:ANIA_01851"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN1851"/>
    <dbReference type="eggNOG" id="KOG0362">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008891_4_2_1"/>
    <dbReference type="InParanoid" id="Q5BC79"/>
    <dbReference type="OMA" id="WGLKYAV"/>
    <dbReference type="OrthoDB" id="1748577at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd03341">
        <property type="entry name" value="TCP1_theta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000008">
        <property type="entry name" value="T-complex protein 1 subunit theta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012721">
        <property type="entry name" value="Chap_CCT_theta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02346">
        <property type="entry name" value="chap_CCT_theta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="476"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="485"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBF85686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="581" mass="62624" checksum="C3A24CFCD905E8E5" modified="2005-04-26" version="1">MSLSLPGPSQAGLFKPGYQSHDAEDGAVIRNIEACQAISQTVQTSLGPYGRNKIVINHLQKMILTSDAATILRELEVVHPAAKLLVMASQQQDAEMGDGTNLVIVLAGELLKKAEELLRLGLKTSDIVQGYEKAQNFALKVLEDLEVDRLQDLRSQTELTKALRTVVASKQSGTEQLLASLVAEAVLSVLPKNPVNFNVDNVRVVKIMGGSLEQSRVIKGMVFGREPEGSIKKAHKAKVGVFSCPIDISQTETKGTVLLKNAQDMLDFTKGEEERLEAAIKELYDSGLRVVVAGAQVGDLALHYLNRFNILVIKILSKFELRRLCRVVGATPLARLGAPMPDEMGSVDVVETTEIGGDRVTVFRQEDATAVTRTATIVLRGATQNHLDDVERAIDDGVNAVKAITKDPRLVPGAGATEIQLVERISAFADRTPGLPQHAIRKYAEAFEVIPRTLAESAGLEATEVLSRLYTAHHQANAGVKSTDGDDDDEEESEDSEEERSSGGGEAEAYWTTGVDLEGSSSSGTLDTVEEGILDLLSSKSWAIRLASESARTVLSVDQIIVARQAGGPKPPGPNPNWDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BCT2</accession>
    <accession>C8VNJ4</accession>
    <name>Q5BCT2_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GED domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_01648</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF85290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_659252.1">
        <property type="nucleotide sequence ID" value="XM_654160.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BCT2"/>
    <dbReference type="STRING" id="227321.Q5BCT2"/>
    <dbReference type="GeneID" id="2875323"/>
    <dbReference type="KEGG" id="ani:ANIA_01648"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN1648"/>
    <dbReference type="eggNOG" id="KOG0446">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_561602_0_0_1"/>
    <dbReference type="InParanoid" id="Q5BCT2"/>
    <dbReference type="OMA" id="LWENAMH"/>
    <dbReference type="OrthoDB" id="415706at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF215">
        <property type="entry name" value="DYNAMIN GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GED" evidence="1">
        <location>
            <begin position="329"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF85290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="417" mass="46971" checksum="9251FAE12BC935D1" modified="2005-04-26" version="1">MKKASDERRAFLLLYKVDCILAVMPCNVDITTQEILKLAEEADPSGIRTMGVLTKPDFATEKATQDVAMDLLLGRRNVLKLGYHVVKNRSADDHNSTLPARLADERAFFAARPWSSIPDRCGITALQTRLRELLTLISRKELSPVKLEIEGRLRKRRLELEIMGPARDDSNAQRQCLGKLAAQPNLKLITKVVKLNEVFSDTFWKRGHKQHFGATWDDDGEASYGSSTDSFPSKVPLNYFCPKPLKGPIMSLIEEVFESIRGPELGTITPGFCWPSSAEADHLPSTTTSTQNLQEKRNERMCKSLEALAVSSTDKEAYIPVKSLRSRCARISLDTLISYYEVARKRFVDIVCQQVKQYFLLETDDGPLRIFSSDLVMSLGTEELEIVAGEDAESERRRDILKREMENLEAALGILRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BDJ4</accession>
    <accession>C8VRT9</accession>
    <name>Q5BDJ4_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">IQ calmodulin-binding motif domain protein (AFU_orthologue AFUA_1G08920)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ANIA_01386</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TCP11 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF87598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_658990.1">
        <property type="nucleotide sequence ID" value="XM_653898.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BDJ4"/>
    <dbReference type="GeneID" id="2877165"/>
    <dbReference type="KEGG" id="ani:ANIA_01386"/>
    <dbReference type="eggNOG" id="KOG1981">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005050_0_0_1"/>
    <dbReference type="InParanoid" id="Q5BDJ4"/>
    <dbReference type="OMA" id="FHAWKTH"/>
    <dbReference type="OrthoDB" id="276323at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008862">
        <property type="entry name" value="Tcp11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12832:SF18">
        <property type="entry name" value="IQ CALMODULIN-BINDING MOTIF DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G08920)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12832">
        <property type="entry name" value="TESTIS-SPECIFIC PROTEIN PBS13 T-COMPLEX 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05794">
        <property type="entry name" value="Tcp11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="21"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="422"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="123"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="27"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="422"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBF87598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="960" mass="105803" checksum="A86B4B83D2C1D1C8" modified="2005-04-26" version="1">MLSESSPPSLSLPAHLATRFARKSSVARRSSAASSRRSSISSLSSQHSNATSHGATATDHIAQHLRRASILDSRKARLADRALHAEKVRLRAALTKAATRNLQREGRALAAQQARERLLAEITAKCEEEVRRAKKKAEDNREKKAAEHARLRIEMAEKLAEAEKRRLLYQQTPRRHRTSSSTLEEKRKVTMKRLSEDAAARRIQRAWKAHHAKLVIKEFLALNLTKERIRDMAFEDVGSLLSEERILSTTAQVLRLCGLQDMTSGTLGGRGAVRTFLSSYLIVTHPAEVLSGDGEQEQDLISKARELIAAFEQVTPLLASGCCPPEAICTDIQTLCEEYNVFFSAFHAWKAHDSSVLIEIMLAQFIELELIWQTVKDDQAGGVADDYRQGIRQNQILLLARLKRLAGSDKAMQMVRDALKKAKRQKKRSASKRAIPRSAEVASATTTTEALTESVASPISESFNNVESAVLQELEKQRTSPHEQFTKILTALPENRALVHELLINKDFKIDEKSYTEPRKRIMEHMCALMRRDIEAGSGTNWIVAMATVIQDRLLRSLRPGNSLHVLISEALDPSLVENQCKAGTFSYDAFFNFMATILPKLCAPYRDPVVNAFAEDTSGDAIERLARLMGIIDLLSLDHTNFMIHVAAPQLIQEAPGYEQRTFERGLQDGSLGIGKSRRFWRTHRKIVADEMRKRDPEDVHGEPQPPALKVYAHGLVDLVFSNAPVSDDLIPETLELDRQRLNALHSQAFKIVATASILLTAKNLLKRDARAQWKAEADRIMSLDLNDVSSDRIQSILESTHPMPPTASAQLAATIRRVLPPVVTACAAASSSAGQTLVEVHTEIPAQGAQSSAAAANPATSGVAGSGVSSFADPVARLILSRLRAHVLSRLSALSASERVRAASTASQSLAGAGMPEFVSQVGQLTEELNKVREVDWLCHGTVYERILGESGPLSPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="103" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BDR1</accession>
    <accession>C8VS62</accession>
    <name>Q5BDR1_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">H/ACA ribonucleoprotein complex subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Nucleolar protein family A member 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">ANIA_01319</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Common component of the spliceosome and rRNA processing machinery. In association with the spliceosomal U4/U6.U5 tri-snRNP particle, required for splicing of pre-mRNA. In association with box C/D snoRNPs, required for processing of pre-ribosomal RNA (rRNA) and site-specific 2'-O-methylation of substrate RNAs. Essential for the accumulation and stability of U4 snRNA, U6 snRNA, and box C/D snoRNAs.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
            <location evidence="1 10">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the eukaryotic ribosomal protein eL8 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF87726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_658923.1">
        <property type="nucleotide sequence ID" value="XM_653831.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BDR1"/>
    <dbReference type="FunCoup" id="Q5BDR1">
        <property type="interactions" value="1222"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5BDR1"/>
    <dbReference type="GeneID" id="2877096"/>
    <dbReference type="KEGG" id="ani:ANIA_01319"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN1319"/>
    <dbReference type="eggNOG" id="KOG3387">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084513_4_1_1"/>
    <dbReference type="InParanoid" id="Q5BDR1"/>
    <dbReference type="OMA" id="IKNQIYA"/>
    <dbReference type="OrthoDB" id="1924699at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031428">
        <property type="term" value="C:box C/D methylation guide snoRNP complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031429">
        <property type="term" value="C:box H/ACA snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030621">
        <property type="term" value="F:U4 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000494">
        <property type="term" value="P:box C/D sno(s)RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000452">
        <property type="term" value="P:snoRNA guided rRNA 2'-O-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031120">
        <property type="term" value="P:snRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000002">
        <property type="entry name" value="NHP2-like protein 1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050257">
        <property type="entry name" value="eL8/uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002415">
        <property type="entry name" value="H/ACA_rnp_Nhp2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004037">
        <property type="entry name" value="Ribosomal_eL8-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018492">
        <property type="entry name" value="Ribosomal_eL8/Nhp2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23105">
        <property type="entry name" value="RIBOSOMAL PROTEIN L7AE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00881">
        <property type="entry name" value="L7ARS6FAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00883">
        <property type="entry name" value="NUCLEARHMG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01082">
        <property type="entry name" value="RIBOSOMAL_L7AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="11">
        <location>
            <begin position="20"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CBF87726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="126" mass="13718" checksum="9DC576D0B5694B45" modified="2005-04-26" version="1">MADDTNAAWPIADEALSQQLLDLVQSATHYRQLKKGANETTKTLNRGTSELVILAADTTPLPIILHLPLLCEDKNVPYVYVPSKLALGRATGVSRPVIAASITTNEASDLMPQIRAIKVQVERLMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="121" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BE99</accession>
    <accession>C8VTB6</accession>
    <name>Q5BE99_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">superoxide dismutase</fullName>
            <ecNumber evidence="4">1.15.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ANIA_01131</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>2 superoxide + 2 H(+) = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell envelope</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Cu-Zn superoxide dismutase family.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="4"/>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF88081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_658735.1">
        <property type="nucleotide sequence ID" value="XM_653643.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BE99"/>
    <dbReference type="STRING" id="227321.Q5BE99"/>
    <dbReference type="GeneID" id="2876907"/>
    <dbReference type="KEGG" id="ani:ANIA_01131"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN1131"/>
    <dbReference type="eggNOG" id="ENOG502S5NX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063073_1_2_1"/>
    <dbReference type="InParanoid" id="Q5BE99"/>
    <dbReference type="OMA" id="FTYHIHV"/>
    <dbReference type="OrthoDB" id="159229at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.200:FF:000007">
        <property type="entry name" value="Cell surface Cu-only superoxide dismutase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.200">
        <property type="entry name" value="Superoxide dismutase, copper/zinc binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053257">
        <property type="entry name" value="Cu-only_SOD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036423">
        <property type="entry name" value="SOD-like_Cu/Zn_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20910">
        <property type="entry name" value="AGAP001623-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <source>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="207" mass="22024" checksum="9C3B0CB5E2414C6C" modified="2005-04-26" version="1">MLFKILPSASLGLAVFTAACAQNISTNAPIVTDNEPVSAHHASLLPKDNTTVYGGITITSRLSSPALAVDVYIGGIPEGQYLNYHIHRAPVPADGNCYLTGGHLDPYGRGQQPPCNMTAPNTCEVGDLSGKHGVAWAPRGEVFRASYSDFFLANTPGAEAYFGDLSWVVHAPNGDRLTCGNFEVLVAAGGAGDYEDDDEELERRWKA</sequence>
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<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
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    <accession>C8VTC8</accession>
    <name>Q5BEB2_EMENI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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        <name evidence="2" type="ORF">ANIA_01118</name>
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        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
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            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
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            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
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            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
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        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
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    <dbReference type="KEGG" id="ani:ANIA_01118"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
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        <property type="component" value="Chromosome VIII"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
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    </evidence>
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        <source>
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    </evidence>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
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            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
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            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF88594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="XP_658488.1">
        <property type="nucleotide sequence ID" value="XM_653396.2"/>
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    <dbReference type="AlphaFoldDB" id="Q5BEZ6"/>
    <dbReference type="STRING" id="227321.Q5BEZ6"/>
    <dbReference type="GeneID" id="2876664"/>
    <dbReference type="KEGG" id="ani:ANIA_00884"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN0884"/>
    <dbReference type="eggNOG" id="ENOG502S06P">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_071891_0_1_1"/>
    <dbReference type="InParanoid" id="Q5BEZ6"/>
    <dbReference type="OMA" id="IHRGVQM"/>
    <dbReference type="OrthoDB" id="190201at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
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    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="210"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF88594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="332" mass="35544" checksum="296FF2A3AFF088E6" modified="2005-04-26" version="1">MAEVSMGDTSGCPPTFSLFPPFIPTVIKQCLTASRYAIVKTATTNSPSASRASTISFSTNSGTGDNTPRPSSSGSASTARNIEDLFSDEDLGNINRDVLALGAPGSCEVGSGVQWNRVDVGLYLLRQAGYEAQNPIRESHHVRSLYIDSMAYFLSALPEDLSSEETLTVRRMLPEKLKPAFTPSAGLELSESTPHSHVLPANTYPAQRSYLHRLLAASIIYFCMLLQYIMPYIKDVLIHLYRYDRAHRVTERVTAATLYVVEKVGRGSVNLGASFLNMYDGKPGSAVSGAAEWWIEGVAGGIYEGVGEGMAILGIGLGPVGGGKGVRNGVGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BFJ6</accession>
    <accession>C8VRQ8</accession>
    <name>Q5BFJ6_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cell wall proline rich protein, putative (AFU_orthologue AFUA_1G13450)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_00684</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF88988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_658288.1">
        <property type="nucleotide sequence ID" value="XM_653196.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BFJ6"/>
    <dbReference type="STRING" id="227321.Q5BFJ6"/>
    <dbReference type="GeneID" id="2876461"/>
    <dbReference type="KEGG" id="ani:ANIA_00684"/>
    <dbReference type="eggNOG" id="ENOG502RD9J">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007264_0_0_1"/>
    <dbReference type="InParanoid" id="Q5BFJ6"/>
    <dbReference type="OMA" id="FNTPDMR"/>
    <dbReference type="OrthoDB" id="5406427at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="409"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="542"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="625"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="767"/>
            <end position="825"/>
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    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="14"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
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    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="118"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="337"/>
            <end position="351"/>
        </location>
    </feature>
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        <location>
            <begin position="374"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="551"/>
            <end position="560"/>
        </location>
    </feature>
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        <location>
            <begin position="582"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="627"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="701"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="785"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="801"/>
            <end position="820"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF88988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="850" mass="91977" checksum="DF7238B383404D5F" modified="2005-04-26" version="1">MSTPLPNPPFVFPARDHDEPDKQDLDTTTNGRPPLPAFSFNPGSVGSNQAPAPAPSNSRMSGHRRQYSEFVGGDQLIIPGNTAAGQTSDETPMAPLKLPPPGPGFSAGGRRRHAHRRSAAISSVDLTAISNALDLKPYVESAPCTSADMTRERRPSLEPSQLLPHSATVLSRPTPPASPQLNLNEASPSSQIPKNERLENPRLCTPTSFLAPESQNATRSSVLARKSDTAITSPKAESSAASQQPRPRPRTADASLMLELSGSTMTDNSSPTKRPNSAAGHSRSHKSMSSNLLIAAFRKSHAEDDGSFPPRISSSDDESDANADDVHEASGSPSFTSKKKEKSKKRQKKVRSWAGSLLIKKGKSHDSKKDDIESNSNKVTPPALTRTNSDFGSGLDVEFDDDNIVVIRTPTNPAHPDSNQTTGETESWASLENSWKPRSFYEQVTTPDTTSPVIDLDAALGPFNTPDLRSGRVPESGFSAATKRMYSGGRRGEFVGPEMRYHRRAESAPEMPPFDRAFLGSHRFPTTSSLENPDVFYEEEEDAFLAATSDSGKDSEEHLQDQATLTESKDDKSEESAESSDTLTGKATDESASGENTGLGIQNPDAGDATSATVATPFQGLFKSDQRFYSNQPGNLTTSFPSQLKTGLEPAKYDEWQRRAPVPPSPEVSPRFLPADSRPVTSPTELCAIPPFSLQGGASHPNSSFPSSEFTPSPEAPRSITTSSTTDPFPHASIEDVPSLTSSASTMTNTLNRVSATFFTRPRLSTDRSASFSAAVYRRSSQPTSKRSSLASLSKLVVGPHAERSKLSHEEKPPGDEREKAKKKGRRISRLMHFWRIKDKEKLDELADQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BG37</accession>
    <accession>C8VSY5</accession>
    <name>Q5BG37_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_00493</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF89373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_658097.1">
        <property type="nucleotide sequence ID" value="XM_653005.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BG37"/>
    <dbReference type="GeneID" id="2876266"/>
    <dbReference type="KEGG" id="ani:ANIA_00493"/>
    <dbReference type="eggNOG" id="ENOG502SPD0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_117282_0_0_1"/>
    <dbReference type="InParanoid" id="Q5BG37"/>
    <dbReference type="OMA" id="CTFIVEA"/>
    <dbReference type="OrthoDB" id="5352317at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010324830" description="Small secreted protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF89373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="145" mass="15199" checksum="64D95C5875A5DBD0" modified="2005-04-26" version="1">MKLSLNLLLATLSLSSTAFAAPSSAKSMMVANTQWTITSLKRVCDTADTKCTWTFGIDTGSDSTDCTYVVTGTPASQANGGPAHCGAYTVTSGWSDQFGAENGFTTLSVVNEGTRQIIWPAYTDKQLAGGNVVTPDQSYTPSVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="110" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BG80</accession>
    <accession>C8VT81</accession>
    <name>Q5BG80_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cytoplasmic tRNA 2-thiolation protein 1</fullName>
            <ecNumber evidence="6">2.7.7.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Cytoplasmic tRNA adenylyltransferase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">NCS6</name>
        <name evidence="6" type="synonym">CTU1</name>
        <name evidence="10" type="ORF">ANIA_00450</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TtcA family. CTU1/NCS6/ATPBD3 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.-" evidence="6"/>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF89461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_658054.1">
        <property type="nucleotide sequence ID" value="XM_652962.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BG80"/>
    <dbReference type="FunCoup" id="Q5BG80">
        <property type="interactions" value="455"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5BG80"/>
    <dbReference type="GeneID" id="2876226"/>
    <dbReference type="KEGG" id="ani:ANIA_00450"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN0450"/>
    <dbReference type="eggNOG" id="KOG2840">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026481_1_3_1"/>
    <dbReference type="InParanoid" id="Q5BG80"/>
    <dbReference type="OMA" id="MGKCERC"/>
    <dbReference type="OrthoDB" id="198857at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002144">
        <property type="term" value="C:cytosolic tRNA wobble base thiouridylase complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032447">
        <property type="term" value="P:protein urmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002143">
        <property type="term" value="P:tRNA wobble position uridine thiolation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd01713">
        <property type="entry name" value="CTU1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000132">
        <property type="entry name" value="Cytoplasmic tRNA 2-thiolation protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03053">
        <property type="entry name" value="CTU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056369">
        <property type="entry name" value="CTU1-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032442">
        <property type="entry name" value="CTU1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000541">
        <property type="entry name" value="Ncs6/Tuc1/Ctu1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011063">
        <property type="entry name" value="TilS/TtcA_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11807">
        <property type="entry name" value="ATPASES OF THE PP SUPERFAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11807:SF12">
        <property type="entry name" value="CYTOPLASMIC TRNA 2-THIOLATION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01171">
        <property type="entry name" value="ATP_bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16503">
        <property type="entry name" value="zn-ribbon_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 6" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="2 6" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal" evidence="8">
        <location>
            <begin position="54"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Cytoplasmic tRNA 2-thiolation protein 1 C-terminal" evidence="9">
        <location>
            <begin position="364"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="336"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="401"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBF89461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="422" mass="46591" checksum="08CA5A4D0A4A730A" modified="2005-04-26" version="1">MAPSLCFKCQKERAVIIRPKNRHKLCRECFLEVFETEVHETITSNSLFHPGERIAIGASGGKDSTVLASVLKTLNERYEYGLDLCLLSIDEGIRGYRDDSLETVKRNAVQYNMPLVIVGYGELYGWTMDQVVEQIGKKGNCTYCGVFRRQALDRGAERLGIKHVVTGHNADDVAETVMMNLLRGDLPRLSRGTSIVTGSAASDIKRSKPLKYAYEKEIVLYAHHKQLDYFSTECIYSPEAFRGSARTLIKDLEKIRPSSILDIVRSGEEMAVLVPITDGGQAAAAGEAEDVSTIGGCGSQSGRTRGGEMAEMEKSLAQNEAAAELETEIKMPSHLAGQVPLPKRTNKPKRQQTQKTSKVGQVLGKCERCGYISSQRTCHACTLLEGLNKNRPKAAIELELDAEEEESSTTLRRQMEQVQLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="147" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BGF0</accession>
    <accession>C8VTQ3</accession>
    <name>Q5BGF0_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peptidyl-prolyl cis-trans isomerase-like 1</fullName>
            <ecNumber evidence="3">5.2.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Rotamase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">ANIA_00380</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="3"/>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF89598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_657984.1">
        <property type="nucleotide sequence ID" value="XM_652892.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BGF0"/>
    <dbReference type="STRING" id="227321.Q5BGF0"/>
    <dbReference type="GeneID" id="2876156"/>
    <dbReference type="KEGG" id="ani:ANIA_00380"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN0380"/>
    <dbReference type="eggNOG" id="KOG0882">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012062_31_2_1"/>
    <dbReference type="InParanoid" id="Q5BGF0"/>
    <dbReference type="OMA" id="GMVEYWR"/>
    <dbReference type="OrthoDB" id="10264753at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd01927">
        <property type="entry name" value="cyclophilin_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000003">
        <property type="entry name" value="Peptidylprolyl isomerase domain and WD repeat-containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000450">
        <property type="entry name" value="Peptidylprolyl isomerase domain and WD-repeat protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625:SF4">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE DOMAIN AND WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0697">Rotamase</keyword>
    <keyword evidence="4 10" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="70"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="114"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="12">
        <location>
            <begin position="476"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="21"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00040798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CBF89598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="629" mass="69471" checksum="2883B21D3FAD92F6" modified="2005-04-26" version="1">MTAEEEQAKLAQNKRPHSEVEADEDGSESSDDDFGPALPSADAPKKKRRKLPFEKVYVNALPASARYSKSLMHKDQLSFVTMTPHTDFLITSSIDGVVKFWKKMAVGVEFVKEFRAHAAEIKGVSVSADGRSFATTGADKTVKIFDVITFDLLAMLTLDFSPRCICWVHPRGASLPLLAVTDDASSTIRIYDGRGENPAPLHTLKSVHRSPISAIAFNDAYNCVVSADESGMIEYWRASDGTFEKPDNVFELKSSTNLFEFKKAKSTPSSITISPSGKQFATISFPDRQVRVFDFGTGKLYRKYDESLSTITDMQQAGTALYTLDAVEFGRRLAVERELENPVTKPKANVIFDESNHFILYGSLYGVKCINTYTNRVVRVYAKDEPFRPLNLAMYQGQPQKKGVVTVSMAASANPLLAEAEERDPILVTTGFAKLRFYLFTNETEISKSTRDVHNEKPRDIDSAAATAASNKSGELGTSAILHTTMGDIHLRLFPSAAPKAVENFTTHAKNGYYNNTIFHRVIRKFMIQGGDPLGDGTGGESIWGGEFEDEFSALKHDKPYTLSMANAGPNTNGSQFFITTEKTPWLDGKHTIFGRAVQGLDVVHKIENVKTVKEKPEVDVKIVSISVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="113" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BGX1</accession>
    <accession>C8VUV2</accession>
    <name>Q5BGX1_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ammonium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ANIA_00209</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ammonia transporter channel (TC 1.A.11.2) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF89970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_657813.1">
        <property type="nucleotide sequence ID" value="XM_652721.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BGX1"/>
    <dbReference type="STRING" id="227321.Q5BGX1"/>
    <dbReference type="GeneID" id="2875977"/>
    <dbReference type="KEGG" id="ani:ANIA_00209"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN0209"/>
    <dbReference type="eggNOG" id="KOG0682">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_33_0_1"/>
    <dbReference type="InParanoid" id="Q5BGX1"/>
    <dbReference type="OMA" id="QWIFWGY"/>
    <dbReference type="OrthoDB" id="534912at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium channel activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072488">
        <property type="term" value="P:ammonium transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3430.10:FF:000003">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="entry name" value="Ammonium transporter AmtB like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001905">
        <property type="entry name" value="Ammonium_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018047">
        <property type="entry name" value="Ammonium_transpt_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00836">
        <property type="entry name" value="amt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029:SF15">
        <property type="entry name" value="AMMONIUM TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029">
        <property type="entry name" value="AMMONIUM TRANSPORTER MEP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111352">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01219">
        <property type="entry name" value="AMMONIUM_TRANSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0924">Ammonia transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="65"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="192"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="306"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="387"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="Ammonium transporter AmtB-like" evidence="10">
        <location>
            <begin position="34"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="451"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CBF89970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="472" mass="50575" checksum="E9F17016BA6DC8B3" modified="2005-04-26" version="1">MSSPEYDPSIPDGGDTTKLDVNAPFVGYEFHAVYIAACTFIVYLILPGIGFLYSGLTRRKSAMTFLFQAFLVLAVTTFQWMFWGYSLTYSRDGGPYIGTLQNFGLMDALAAPSPGSAVLPEVLFCLYQLLFGSCTVMIVVGGAFERGGILASLVFAFVWETIVYCPLARWTWSSHGWLYNLPSVDFAGGGPVHIASGCAALAYAVVLGKRKGYPDASMKRPHNTTLVFLGTVFIWTGWLGFNGGSTLNASVRSYMAVMNTNIAGSTGVLGWVLVDMIRNKGKFSMVGACEGAIAGLVGITPCAGCVTFWLGALVGFLTGIVCSACKNLNEWIRVDEGMDVFKLHGVGGMVGSFLTGIFADQYISALDGDSLIPGAINGEGVQVGKQLAEICAISAYSFGVTWVILMVMKFIPYLGLRANEEAEMVGLDRSFFVDEQIGDYSMLDGINSSPLMGVSKTPSSEVQQTAAETKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="124" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BH71</accession>
    <accession>C8VQL7</accession>
    <name>Q5BH71_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">U1 small nuclear ribonucleoprotein, putative (AFU_orthologue AFUA_5G11930)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">ANIA_00109</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRM U1 A/B'' family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF90183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_657713.1">
        <property type="nucleotide sequence ID" value="XM_652621.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BH71"/>
    <dbReference type="FunCoup" id="Q5BH71">
        <property type="interactions" value="166"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5BH71"/>
    <dbReference type="GeneID" id="2875883"/>
    <dbReference type="KEGG" id="ani:ANIA_00109"/>
    <dbReference type="eggNOG" id="KOG4206">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041869_0_1_1"/>
    <dbReference type="InParanoid" id="Q5BH71"/>
    <dbReference type="OMA" id="VRMIPTK"/>
    <dbReference type="OrthoDB" id="266020at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030619">
        <property type="term" value="F:U1 snRNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd12246">
        <property type="entry name" value="RRM1_U1A_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12247">
        <property type="entry name" value="RRM2_U1A_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000039">
        <property type="entry name" value="U1 small nuclear ribonucleoprotein A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000029">
        <property type="entry name" value="U2 small nuclear ribonucleoprotein B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10501">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN A/U2 SMALL NUCLEAR RIBONUCLEOPROTEIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="9 13" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="14"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="177"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="119"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="229"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="119"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CBF90183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="252" mass="27765" checksum="E482E4728F0B8623" modified="2005-04-26" version="1">MATVPVPSNIPPNPTVYVRNLEERIKLDQLKEALSEIFSEYGTILEIVAKRNLKAKGQAFIVFDNVDSATRAIDEVNGFDLFDKPMVLDYAKTRSDATVRREGGDEELEAHKRRRLAEKERRQAHEALEAQKKLKRPPVGAPEAPGRPVKAAKGAGLKPTSGAAAAVIPDEYLPPNKILFLRELPDTADQGSLTAVFGRFEGFREVRLVPGRKGIAFVEYENESGAISAKEATSGMPMGPEGKPIRVTYQRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>C8UZX8</accession>
    <name>C8UZX8_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_10749</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF70656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467061.1">
        <property type="nucleotide sequence ID" value="XM_050612607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8UZX8"/>
    <dbReference type="GeneID" id="74896580"/>
    <dbReference type="KEGG" id="ani:ANIA_10749"/>
    <dbReference type="HOGENOM" id="CLU_2049679_0_0_1"/>
    <dbReference type="InParanoid" id="C8UZX8"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF70656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="120" mass="13189" checksum="2DFFC19A12F35DF0" modified="2009-11-03" version="1">MSKHQSMLIHSSSDSAFDLLFFFFFSFFSDPSTAGSTSESLFRFFFFSFFSFLAFSVSSSSSGATNAFSRSFIFSSRFIRCLSITSSFCARSLASLDKKYSPDSICRSTLLFSGAGGKGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>C8V1K0</accession>
    <name>C8V1K0_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_06245</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF69867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050466959.1">
        <property type="nucleotide sequence ID" value="XM_050611535.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V1K0"/>
    <dbReference type="GeneID" id="2870837"/>
    <dbReference type="KEGG" id="ani:ANIA_06245"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN6245"/>
    <dbReference type="eggNOG" id="ENOG502S0PN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061830_1_0_1"/>
    <dbReference type="InParanoid" id="C8V1K0"/>
    <dbReference type="OMA" id="WIHIWIA"/>
    <dbReference type="OrthoDB" id="5397827at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF69867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="260" mass="29454" checksum="05AC7148CB312493" modified="2009-11-03" version="1">MPPSAIPPFLLPRGVPSARAILFLSRSSRIGRLPPTHRCASTNSSSDNSQNPRVLAQPDKFRPPSHPARRVVPTRNGKVVNYPGPKFSEKEEAERAKKKYPNMFPPEGTVMFRFLTSRWIHVWIAFGVLTSLATFTFTTNFKATSPFAHLLPPWSALLSHPIDTISQALSVFRMHVQHTSVETREKRMRAVEDAEKRRQFRIAHGLEEPSEQDLAKEETRAEQVDDQSPIAPEARDGAGAGEYVDWEGKRRPIKKWLGIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>C8V2A9</accession>
    <name>C8V2A9_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Large ribosomal subunit protein uL14m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ANIA_06146</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uL14 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF70091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050466992.1">
        <property type="nucleotide sequence ID" value="XM_050611849.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V2A9"/>
    <dbReference type="FunCoup" id="C8V2A9">
        <property type="interactions" value="368"/>
    </dbReference>
    <dbReference type="STRING" id="227321.C8V2A9"/>
    <dbReference type="GeneID" id="2870880"/>
    <dbReference type="KEGG" id="ani:ANIA_06146"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN6146"/>
    <dbReference type="eggNOG" id="KOG0901">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095071_2_0_1"/>
    <dbReference type="InParanoid" id="C8V2A9"/>
    <dbReference type="OMA" id="IVCVVQK"/>
    <dbReference type="OrthoDB" id="274765at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00337">
        <property type="entry name" value="Ribosomal_uL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.150.20:FF:000005">
        <property type="entry name" value="50S ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.150.20">
        <property type="entry name" value="Ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01367">
        <property type="entry name" value="Ribosomal_uL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000218">
        <property type="entry name" value="Ribosomal_uL14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005745">
        <property type="entry name" value="Ribosomal_uL14_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019972">
        <property type="entry name" value="Ribosomal_uL14_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036853">
        <property type="entry name" value="Ribosomal_uL14_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01067">
        <property type="entry name" value="rplN_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761">
        <property type="entry name" value="50S/60S RIBOSOMAL PROTEIN L14/L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL14M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00238">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01374">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50193">
        <property type="entry name" value="Ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00049">
        <property type="entry name" value="RIBOSOMAL_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6 7" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBF70091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="131" mass="14304" checksum="21BB071FDA8D1642" modified="2009-11-03" version="1">MIQLKTLLNCIDNSGAAVVECVNVLKKKRAATVGDRIVIVVQKQRNFGPEGTSSTGIANKVRRGDIRHAVVVRVKKEMQRPDGTLVKFDDNACVLVNKSGDPIGTRMNGVVATELRGRQWSKILSLAPMHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>C8V2Z0</accession>
    <name>C8V2Z0_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Probable vacuolar protein sorting-associated protein 16 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ANIA_06911</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Essential for vacuolar protein sorting. Required for vacuole biogenesis, stability and to maintain vacuole morphology.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the VPS16 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF71716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467194.1">
        <property type="nucleotide sequence ID" value="XM_050611140.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V2Z0"/>
    <dbReference type="FunCoup" id="C8V2Z0">
        <property type="interactions" value="1044"/>
    </dbReference>
    <dbReference type="STRING" id="227321.C8V2Z0"/>
    <dbReference type="GeneID" id="2870626"/>
    <dbReference type="KEGG" id="ani:ANIA_06911"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN6911"/>
    <dbReference type="eggNOG" id="KOG2280">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008909_1_0_1"/>
    <dbReference type="InParanoid" id="C8V2Z0"/>
    <dbReference type="OMA" id="WCGDDCL"/>
    <dbReference type="OrthoDB" id="1792at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042144">
        <property type="term" value="P:vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.780:FF:000002">
        <property type="entry name" value="Probable vacuolar protein sorting-associated protein 16 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000635">
        <property type="entry name" value="Probable vacuolar protein sorting-associated protein 16 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.780">
        <property type="entry name" value="Vps16, C-terminal region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016534">
        <property type="entry name" value="VPS16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006925">
        <property type="entry name" value="Vps16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038132">
        <property type="entry name" value="Vps16_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006926">
        <property type="entry name" value="Vps16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12811">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING VPS16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12811:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 16 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04840">
        <property type="entry name" value="Vps16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04841">
        <property type="entry name" value="Vps16_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007949">
        <property type="entry name" value="VPS16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0653">Protein transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Vps16 N-terminal" evidence="4">
        <location>
            <begin position="7"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="Vps16 C-terminal" evidence="3">
        <location>
            <begin position="503"/>
            <end position="811"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR007949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBF71716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="829" mass="93284" checksum="D3C2FDBD2AE4130A" modified="2009-11-03" version="1">MAPSNPLANWERLGSSFYRKVPLYHSVFGEDVELENYIVAGAPYGGAIALYRDESKPLRFRDAQTGKSNIDIYSRSGKLINRLNWEHGTIRGLGWSDQEELLVITEDGTVRRYFGLYGDFTSFSLGNGAEEYGVRACRFWNSGFVALLANNQLIAVSSYNEPRPRLLAQCPEGEVASWSLIPPAYTLSRSVEVLLAVDKTIYLVDPTEAEDKVLQNGPFKHASVSPTGQFVALLTAEGKVWVVSSDFQSKYSEYDPDSRVTPRAVEWCGNDAVVIAWEDEVHLIGPNGAAARYWYDGTVHVLPEFDGVGLLTNDTYEFLHKVSDVTETIFRLGSTSPASVLLDSIDLLEKKSPKADDNIQRIKPSLPEAVDMCVKASGLEFDAYWQKRLLKAASFGKSVLDLYNSDEFVEMTEKLRVLQAVRDFQIGLAVSYDQYMRLTSEKLIERLVNRRNYLLAIRISEYLQLPADKIYVHWGSSKVKVSTVDDEAVCKLIVQRLDGKPGISFEAIAQAAYDEGRSHLATQLLNHEPRAGKQVPLLLNMEEDEIALDKALQSGDDDLVNYVLLHLKSKLPIASFFRMINTRPMASALVETTAREEDPELLKDLFYQDDRPLDGSNVLLSDALKESDLPRKQEKLLLASRLLSDSKDPTLVLHRNLLNESSQLLKTQEALDKDLAERSEFLGLSLNETVYRLIRSGYGRRAQKIQSDFKMPERTYWWLRLRALVAKRDWGELEEIGKIKKSPIGWEPFYNEILGAGNTKLASVFVPKCTNLPAEERIEMWVKCGMIVKAGEEAFKAKDINTLELLQAKASGPSAVEIGRMINQLRPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>C8V742</accession>
    <name>C8V742_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Septin-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ANIA_08182</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF74054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467270.1">
        <property type="nucleotide sequence ID" value="XM_050611221.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V742"/>
    <dbReference type="FunCoup" id="C8V742">
        <property type="interactions" value="132"/>
    </dbReference>
    <dbReference type="STRING" id="227321.C8V742"/>
    <dbReference type="GeneID" id="2869036"/>
    <dbReference type="KEGG" id="ani:ANIA_08182"/>
    <dbReference type="eggNOG" id="KOG2655">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017718_8_0_1"/>
    <dbReference type="InParanoid" id="C8V742"/>
    <dbReference type="OMA" id="EASHAEI"/>
    <dbReference type="OrthoDB" id="416553at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015630">
        <property type="term" value="C:microtubule cytoskeleton"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031105">
        <property type="term" value="C:septin complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005940">
        <property type="term" value="C:septin ring"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061640">
        <property type="term" value="P:cytoskeleton-dependent cytokinesis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd01850">
        <property type="entry name" value="CDC_Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000238">
        <property type="entry name" value="Cell division control 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016491">
        <property type="entry name" value="Septin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006698">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="5">
        <location>
            <begin position="27"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="317"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBF74054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="384" mass="44304" checksum="C329EAC7A295880C" modified="2009-11-03" version="1">MAPVNETASPIGIANLPNQRHKIVAKRGAAFTIMVAGESGLGKTTFINTLFSTTIKNYADHKRRHQKQVDRTVEIEITKAELEEKFFKVRLTVIDTPGFGDYVNNRDSWQPIIEFLDDQHESYMLQEQQPRRTDKIDMRVHACLYFIRPTGHTLKPLDIEVMKRLSSRVNLIPVIAKADTLSPADLSRFKQRIQAVIEAQGIKIYTPPIEEDDETAAAHARSLMAAMPFAVIGSEKDVKTNDGRVVKGRQYAWGVAEVEDEEHCDFKKLRSILIRTHMLDLIHTTEEQHYEAYRAQQMETRKFGEARPRKLDNPKFKEEEENLRKRFTDQVKLEESRFRQWEQKLIAERDRLNKDLEATHAAIKALESEIESLQGSSTRSHGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>C8V7N2</accession>
    <name>C8V7N2_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_03680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF75627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467493.1">
        <property type="nucleotide sequence ID" value="XM_050611464.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V7N2"/>
    <dbReference type="GeneID" id="2873104"/>
    <dbReference type="KEGG" id="ani:ANIA_03680"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN3680"/>
    <dbReference type="HOGENOM" id="CLU_2196932_0_0_1"/>
    <dbReference type="InParanoid" id="C8V7N2"/>
    <dbReference type="OrthoDB" id="197676at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF75627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="92" mass="9843" checksum="045618CE96FC5910" modified="2009-11-03" version="1">MPIPLYTDQTTNQLQGQANPNTTQFSQQAGAPGTTSGSSSTSNTGPAMTTSFAQSSFPSAMDAQGQRLSKEEADRLYEERMEDEYAKREGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>C8VA12</accession>
    <name>C8VA12_EMENI</name>
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        <submittedName>
            <fullName evidence="8">Zn(II)2Cys6 transcription factor (Eurofung)</fullName>
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    <gene>
        <name evidence="8" type="ORF">ANIA_08732</name>
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    <organism evidence="8 9">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF78142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_682001.2">
        <property type="nucleotide sequence ID" value="XM_676909.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VA12"/>
    <dbReference type="GeneID" id="2868410"/>
    <dbReference type="KEGG" id="ani:ANIA_08732"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN8732"/>
    <dbReference type="eggNOG" id="ENOG502QVPF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_685166_0_0_1"/>
    <dbReference type="InParanoid" id="C8VA12"/>
    <dbReference type="OrthoDB" id="4456959at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF50">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="12"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBF78142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="490" mass="54794" checksum="73E17E3D32DD9116" modified="2009-11-03" version="1">MAPVKKPRPAFSCLTCRTRKVRCGRERPECANCRRMNKVCEYQSTSKVSDNQSRHDQIHTDRSNVSRLDVVSRLPSRVRPVNDSLLGLMPFRKKATVDPLPPHINFLTIASVFERIPDRHACDGFVQTFITSVYPLYPLIDLPDFQSWYAVFWQWCHEAGDRRSTIIPNTLLEDVTMNCVLFAVLYAGAAASAHTSQESVTTRNLESAVSAILTSCDHLRRPTVNTVAASLIIDPFMSKDLGSLEYGLWVSSTVRLAQSIGLHRQEHVTPDRDIDFGSALEARLERRIWAHIVWLDVQHSLLTGLPLAVTATAGSRFGSLPTPISGAGPDTLAGDTAILFQARSEIARIQHRLIDTVHNASASTGLISEEIYRGDYHEQRGRFLGSEVGDVDSPAHGNPDPQSFLTIPVTANTFLRSEYRHRSRSRPVVESYNSPLHPIPPNLLIYRIVFRICATPLVLRALCGTDSVCFSVGIILVPLAWLYRCIFWIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>C8VCH5</accession>
    <name>C8VCH5_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">alpha-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ANIA_10935</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing (1-&gt;4)-linked alpha-D-glucose residues with release of alpha-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.20"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.20" evidence="3"/>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF78517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467840.1">
        <property type="nucleotide sequence ID" value="XM_050611861.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VCH5"/>
    <dbReference type="STRING" id="227321.C8VCH5"/>
    <dbReference type="GeneID" id="74896684"/>
    <dbReference type="KEGG" id="ani:ANIA_10935"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN10935"/>
    <dbReference type="eggNOG" id="KOG1066">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005043_1_0_1"/>
    <dbReference type="InParanoid" id="C8VCH5"/>
    <dbReference type="OMA" id="FNTWHYG"/>
    <dbReference type="OrthoDB" id="1334205at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004558">
        <property type="term" value="F:alpha-1,4-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090599">
        <property type="term" value="F:alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006491">
        <property type="term" value="P:N-glycan processing"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd06595">
        <property type="entry name" value="GH31_u1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048395">
        <property type="entry name" value="Glyco_hydro_31_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762">
        <property type="entry name" value="ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762:SF89">
        <property type="entry name" value="ALPHA-XYLOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21365">
        <property type="entry name" value="Glyco_hydro_31_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 31 TIM barrel" evidence="5">
        <location>
            <begin position="193"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 31 C-terminal" evidence="6">
        <location>
            <begin position="505"/>
            <end position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF21365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBF78517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="813" mass="92735" checksum="6EE45166E0BBDFDC" modified="2009-11-03" version="1">MEGHVFETHPRANPGAVVQGAQYRFTLLSERLIRFEWAEDGQFEDRASTFAIDREFPVPRFRIVDGDELEIITEYFHVSYTKQKFSPESLVFHFSGKSVKYGTPWRFGTPTEFNLGGTARTLDGVDGRCDMGQGVLSKAGYAVLDDSKSMLFDGKGFVAPRQAGDRADWYLFCYGRDYKAAIKAFYAVSGKQPVVPRFVLGNWWSRYYAYHQDEYVALVDKFLEHSIPLSVAVLDMDWHYVSDERVPHAGWTGYTWNEKLFPNPKKFRRDIHQRQLRITMNDHPHGGIHAHEAAYERMALFLDHDTRDRNPILFDPASPKFMEAYLSILHHRLELDACDFWWIDWQQGPYSKIPGFDPLWLLNHFQYLESKHYGSVPLIFSRYGGPGSHRYPIGFSGDTVVTWESLAFQPEFTATASNIGYGWWSHDIGGHIRGIRDDELLIRWTQLGVFSPVMRLHSTSSRWNSKEPWLYGDECFRVMARFLRFRHRLVPYLYTQNVSGSFNDEPLVQPMYWSWPNEPNAYEVPNQYFLGSELLVAPIVQPRDKRTNLASVKAWLPPGKRFVDIFCGTVYDGGRMVTLYRPIDKYPVLAPEGSIVTLTSEACPGNGCLNPSGIEALVIVGKDGRARLIEDVVDDDFFKERVAPAPNLRVAWNIEFIQATGKLTARIPAGKLNLNLRFLGMNLKPQDFRLLGNGRDLKNDGIDVRLAQYGNKPCLSVFFSDFVSLQPTTITISLGPDPQLEVVDHTASLEELIRGYQAEVRMKDQLWNAIEEGKGRPLCIISSLLALGYDEAIVGPLVELITADSRPCPGWMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>C8VDC5</accession>
    <name>C8VDC5_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">SRP54-type proteins GTP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ANIA_07108</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the GLYK kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF79067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467904.1">
        <property type="nucleotide sequence ID" value="XM_050611935.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VDC5"/>
    <dbReference type="FunCoup" id="C8VDC5">
        <property type="interactions" value="321"/>
    </dbReference>
    <dbReference type="STRING" id="227321.C8VDC5"/>
    <dbReference type="GeneID" id="2869866"/>
    <dbReference type="KEGG" id="ani:ANIA_07108"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN7108"/>
    <dbReference type="eggNOG" id="KOG2878">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056986_0_0_1"/>
    <dbReference type="InParanoid" id="C8VDC5"/>
    <dbReference type="OMA" id="FWRSLHP"/>
    <dbReference type="OrthoDB" id="347435at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001691">
        <property type="entry name" value="Probable ATP-dependent kinase TDA10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10285">
        <property type="entry name" value="URIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00061312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBF79067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="321" mass="36471" checksum="03A83DB14B546218" modified="2009-11-03" version="1">MPEIFDDKSQHCIPFLLQRLKAHQARHSNDPANTPPFFLGLNGVQGAGKTVLVSTLNSILRSPPYSLAVVTLSLDDLYLTHEDQVSLAKSNPTNPLLQHRGQPGTHDLPLAQSVFSALRAGRPTAIPQYDKSAFSGQGDRVPMEQWETVNVEGQEQIKVLIFEGWSVGFRAWDDDILKQKWEDAVKRKEQDKEYRGRLGHVKFEDVRKVNEALRGYDVLTDQLDALIHIDAQDNHFVYEWRQEQERTLRATKGIGMTEEQVNRFVDGYYPSYELYSEALRAGAFRPIPYSTTASASPEGWEGRQLRLVVDKGRKVQEVIKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>C8VDE5</accession>
    <name>C8VDE5_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ANIA_07091</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF79103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_664695.2">
        <property type="nucleotide sequence ID" value="XM_659603.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VDE5"/>
    <dbReference type="STRING" id="227321.C8VDE5"/>
    <dbReference type="GeneID" id="2870056"/>
    <dbReference type="KEGG" id="ani:ANIA_07091"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN7091"/>
    <dbReference type="eggNOG" id="KOG0733">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004471_2_3_1"/>
    <dbReference type="InParanoid" id="C8VDE5"/>
    <dbReference type="OMA" id="FRSRIHM"/>
    <dbReference type="OrthoDB" id="10042665at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19481">
        <property type="entry name" value="RecA-like_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056599">
        <property type="entry name" value="AAA_lid_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054289">
        <property type="entry name" value="DUF7025"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411:SF3">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411">
        <property type="entry name" value="FAMILY ATPASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23232">
        <property type="entry name" value="AAA_lid_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22942">
        <property type="entry name" value="DUF7025"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="3">
        <location>
            <begin position="400"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="659"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="10"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="660"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="703"/>
            <end position="726"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBF79103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="753" mass="86602" checksum="7BE89E4E7D4C7DD7" modified="2009-11-03" version="1">MIPSTKIEDIERTRAMAAQLRRERDELRCLVEFMDHDMRDIFEIKRAIQANTLREIRLSTSGNFQDDDSRRQAFRVLHVTGGRVCFDTKKLSYFDPVNYRVWDSESEDERRCRDAVRRSSAQMTNFIIDCFYLESDGVRLAPRPKRFAITPYSGKRPIASLPLRPLQFDPQKEVLEKQLVARGARFMEVAQGKHMEYHGNTIEESKNSQYRHRNHRIEAFEVHGEVVVDQEAGVTHFQDTLPAFSLGTGGGIVLTHTEPDSREVSDFFPQKSDGDWVTDVFNDAAFEEYRHSEYFTTTDLLTSRPVKDIQLSDDQLLLLPPRVYGYSLLDRRWVALNVSLLQEISIHDKQARSKLEELVLPTEHKRVLQALITNQVRLPHGGSNHVQEQLSMDVVSAKGKGLIILLHGAPGVGKTSTAECIAIELNRPLLSITCGHIGTVAEEAEKNLDSFCKLAHRWRCVLLLDEADVFLAKRERGDIARNSLVSVFLRVLEYFSGVIILTTNRVGEFDEAFRSRIHVCLYYPKLEERQTKEIWEKNIQRVKESNLNLDMEEKKIRRFADQHWQRNLDRPTRRWNGRQIKNAFQTAIALANWEFYDEKNVAKLERPLLKAKHFQYVAKITAHFDDYISDIYGTFDEDTYSFLAARDALRVDEASAMFASRSTTQENSRASKSGIVRRGTDFRSPPANPGKPQGSNFGRYSSDDDESTDEEESEESEADNEEDDQADEVKKLELQLQLAKLKNKKASSRGSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>C8VDM6</accession>
    <name>C8VDM6_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_07758</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF80048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468038.1">
        <property type="nucleotide sequence ID" value="XM_050612081.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VDM6"/>
    <dbReference type="GeneID" id="2869468"/>
    <dbReference type="KEGG" id="ani:ANIA_07758"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN7758"/>
    <dbReference type="eggNOG" id="KOG4300">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037990_6_1_1"/>
    <dbReference type="InParanoid" id="C8VDM6"/>
    <dbReference type="OMA" id="CEHVVNP"/>
    <dbReference type="OrthoDB" id="540004at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052356">
        <property type="entry name" value="Thiol_S-MT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45036:SF1">
        <property type="entry name" value="METHYLTRANSFERASE LIKE 7A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45036">
        <property type="entry name" value="METHYLTRANSFERASE LIKE 7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="82"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF80048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="334" mass="36376" checksum="E21A308DB4678BAF" modified="2009-11-03" version="1">MARDDLTTRQWLLALLEPAKILTWAMSYYVGANFKAVLSGRLLAPILNAHQLRDEAFGKFWVAFSSNREEPPSTDHLSPGDTGATGATGATGASKSPFPSSSLSSSAKEDEQKALQSSDLIPPIISQATGVVLDVGPGTGTQIPLLSQIPAANISVIYGAEPCLGLHEELRRRAADYGLAQKYTILPCSVVQKELGPELKSIGLVSDSSDGGDGGVFDSIITIRVLCSVPDPETTISYLYSLLKPGGKLLVVEHVVNPWNTPKGSILARMMQGFYHFFGWRWVMGDCCLNRDTERLLRRAPERAGDGGWESVDLERWFERTCMVYIAGVFVKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>C8VDN4</accession>
    <name>C8VDN4_EMENI</name>
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        <recommendedName>
            <fullName evidence="4">Transposase Tc1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_07765</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF80063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468042.1">
        <property type="nucleotide sequence ID" value="XM_050612086.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VDN4"/>
    <dbReference type="GeneID" id="2869688"/>
    <dbReference type="KEGG" id="ani:ANIA_07765"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN7765"/>
    <dbReference type="eggNOG" id="ENOG502SYTZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1540029_0_0_1"/>
    <dbReference type="InParanoid" id="C8VDN4"/>
    <dbReference type="OMA" id="WGAKRIH"/>
    <dbReference type="OrthoDB" id="5151590at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF80063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="174" mass="19687" checksum="9FF46299C1BA7D98" modified="2009-11-03" version="1">MNVQRLHTEDDAGIRYGSGVKLSHNSMSRRRKELTPDIRARLCELKAIGWKVTKIHKRYPDIPYSTIRSTIMRENARKNQQSCPRSGRPKKISPEEQQQLLGLVETDQHIKMRELSEAVQSGPSVRTVQRLLSTLQKKKQSNKHAGYIAERISSEVSGLDSARQSVGAGDQVLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>C8VEU2</accession>
    <name>C8VEU2_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Thioredoxin, putative (AFU_orthologue AFUA_6G10300)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ANIA_08571</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF80822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468124.1">
        <property type="nucleotide sequence ID" value="XM_050612177.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VEU2"/>
    <dbReference type="STRING" id="227321.C8VEU2"/>
    <dbReference type="GeneID" id="2868877"/>
    <dbReference type="KEGG" id="ani:ANIA_08571"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN8571"/>
    <dbReference type="eggNOG" id="KOG0907">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090389_14_0_1"/>
    <dbReference type="InParanoid" id="C8VEU2"/>
    <dbReference type="OMA" id="CQALMPD"/>
    <dbReference type="OrthoDB" id="10263751at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000245">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46115">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="3">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBF80822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="108" mass="11779" checksum="E022E2CC555404FA" modified="2009-11-03" version="1">MSHGKVIQVDNPVIFKALVSSGPVVVDFFATWCGPCKAVAPVVGKFSETYTGVKFLQVDVDKARSIAQEHQIRAMPTFVLYKDGKPLDKRVVGGNMKELEEGIKSIIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>C8VF94</accession>
    <name>C8VF94_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ANIA_11470</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF81103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468165.1">
        <property type="nucleotide sequence ID" value="XM_050612221.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VF94"/>
    <dbReference type="GeneID" id="74897047"/>
    <dbReference type="KEGG" id="ani:ANIA_11470"/>
    <dbReference type="HOGENOM" id="CLU_2512619_0_0_1"/>
    <dbReference type="InParanoid" id="C8VF94"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF81103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="85" mass="9711" checksum="5EFBDC162EDF9D8F" modified="2009-11-03" version="1">MLLMQRIILGEHKIVPRPTYYVMKILRTTSPVNMPTLPTIPYPLLNNAVLDIDVNACYSFQLKDVPHGTILPSKLTVLPVFESRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>C8VFJ6</accession>
    <name>C8VFJ6_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">14-3-3 protein (Eurofung)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ANIA_05744</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 14-3-3 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF81292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468201.1">
        <property type="nucleotide sequence ID" value="XM_050612259.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VFJ6"/>
    <dbReference type="SMR" id="C8VFJ6"/>
    <dbReference type="STRING" id="227321.C8VFJ6"/>
    <dbReference type="GeneID" id="2872034"/>
    <dbReference type="KEGG" id="ani:ANIA_05744"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN5744"/>
    <dbReference type="eggNOG" id="KOG0841">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058290_0_0_1"/>
    <dbReference type="InParanoid" id="C8VFJ6"/>
    <dbReference type="OMA" id="SKGTDKH"/>
    <dbReference type="OrthoDB" id="10260625at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.190.20:FF:000002">
        <property type="entry name" value="14-3-3 protein epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.190.20">
        <property type="entry name" value="14-3-3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000308">
        <property type="entry name" value="14-3-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023409">
        <property type="entry name" value="14-3-3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036815">
        <property type="entry name" value="14-3-3_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023410">
        <property type="entry name" value="14-3-3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18860">
        <property type="entry name" value="14-3-3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00244">
        <property type="entry name" value="14-3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000868">
        <property type="entry name" value="14-3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00305">
        <property type="entry name" value="1433ZETA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00101">
        <property type="entry name" value="14_3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48445">
        <property type="entry name" value="14-3-3 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00796">
        <property type="entry name" value="1433_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="14-3-3" evidence="4">
        <location>
            <begin position="5"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="232"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="258"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with phosphoserine on interacting protein" evidence="2">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with phosphoserine on interacting protein" evidence="2">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000868-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBF81292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="270" mass="30655" checksum="FE95E7DCF4611068" modified="2009-11-03" version="1">MTSERENKTFLARLCEQAERYDEMVTYMKEVANIGGELTVDERNLLSVAYKNVVGTRRASWRIISSIEQKEESKGSEQHVSIIREYRQKIETELEKVCQDVLDVLDESLIPKAETGESKVFYYKMKGDYHRYLAEFASGNKRKLAATAAHEAYKNATDVAQTELTPTHPIRLGLALNFSVFYYEILNSPDRACHLAKQAFDDAIAELDSLSEESYRDSTLIMQLLRDNLTLWTSSDGNEPENVSAPKEEKPEEDAAAPEEKPEEAKAPES</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>C8VGD1</accession>
    <name>C8VGD1_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nitrilase family protein (Nit3), putative (AFU_orthologue AFUA_6G13230)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ANIA_10675</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF81817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468260.1">
        <property type="nucleotide sequence ID" value="XM_050612322.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VGD1"/>
    <dbReference type="SMR" id="C8VGD1"/>
    <dbReference type="FunCoup" id="C8VGD1">
        <property type="interactions" value="666"/>
    </dbReference>
    <dbReference type="STRING" id="227321.C8VGD1"/>
    <dbReference type="GeneID" id="74896537"/>
    <dbReference type="KEGG" id="ani:ANIA_10675"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN10675"/>
    <dbReference type="eggNOG" id="KOG0806">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030130_1_0_1"/>
    <dbReference type="InParanoid" id="C8VGD1"/>
    <dbReference type="OMA" id="MQSKPYA"/>
    <dbReference type="OrthoDB" id="10250282at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050152">
        <property type="term" value="F:omega-amidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043605">
        <property type="term" value="P:amide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006528">
        <property type="term" value="P:asparagine metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006107">
        <property type="term" value="P:oxaloacetate metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd07572">
        <property type="entry name" value="nit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.110.10:FF:000002">
        <property type="entry name" value="Nitrilase family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045254">
        <property type="entry name" value="Nit1/2_C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001110">
        <property type="entry name" value="UPF0012_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23088">
        <property type="entry name" value="NITRILASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23088:SF30">
        <property type="entry name" value="OMEGA-AMIDASE NIT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01227">
        <property type="entry name" value="UPF0012"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="3">
        <location>
            <begin position="9"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBF81817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="293" mass="31665" checksum="B6173F2C87F9459A" modified="2009-11-03" version="1">MTALLKKPLKLALVQLASGADKAANLAHARTKVLEAAKAGASLIVLPECFNSPYGTQYFPKYAETLLPSPPTKEQSPSYHALSALAAEAKAYLVGGSIPELETTSKKYYNTSLVFSPSGALIGTHRKTHLFDIDIPGKITFKESEVLSPGNQLTIVDLPDYGKIGLAICYDIRFPEPGMTAARKGAFALIYPGAFNTTTGPLHWQLLARARAVDNQVYVALCSPARDTTATYHAYGHSLVADPSAKILSEAEESETIVYADLDPETIESTRKGIPIYTQRRFDLYPDVSAGKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>C8VHD0</accession>
    <name>C8VHD0_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Casein kinase substrate phosphoprotein PP28 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_10411</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF82707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468375.1">
        <property type="nucleotide sequence ID" value="XM_050612453.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VHD0"/>
    <dbReference type="GeneID" id="2874343"/>
    <dbReference type="KEGG" id="ani:ANIA_10411"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN10411"/>
    <dbReference type="eggNOG" id="KOG3375">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068528_0_0_1"/>
    <dbReference type="InParanoid" id="C8VHD0"/>
    <dbReference type="OMA" id="NQMGLWR"/>
    <dbReference type="OrthoDB" id="21120at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019380">
        <property type="entry name" value="Casein_kinase_sb_PP28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039876">
        <property type="entry name" value="HAP28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22055">
        <property type="entry name" value="28 KDA HEAT- AND ACID-STABLE PHOSPHOPROTEIN PDGF-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10252">
        <property type="entry name" value="PP28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Casein kinase substrate phosphoprotein PP28" evidence="2">
        <location>
            <begin position="157"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF82707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="260" mass="28714" checksum="4DD93A1E5929B534" modified="2009-11-03" version="1">MAPRGRGGKFSKPSRGGGKHFSRDIQTVDKDGNPVSMWRDPADDPETSEEEEASTGDSDDESENEAGPSTITPNFPQDTVSENRSELSREERRALAKAKKAAAALRKAQGPAQPGDLPPSDSESEIEAPLTNGNKSKGKVSAPVADSEESDLDLPSNPNYTSKSKKTEEGEGEEAHLSRREREAIEAQQARERYMKLHAEGKTEEARADLARLAIVRERREQERLRKEAEKEEKAELARQRAEEREKKLAKVGKKKGGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>C8VI46</accession>
    <name>C8VI46_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_11381</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF83084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468422.1">
        <property type="nucleotide sequence ID" value="XM_050612509.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VI46"/>
    <dbReference type="GeneID" id="74896977"/>
    <dbReference type="KEGG" id="ani:ANIA_11381"/>
    <dbReference type="HOGENOM" id="CLU_3032319_0_0_1"/>
    <dbReference type="InParanoid" id="C8VI46"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002992206" evidence="1">
        <location>
            <begin position="20"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF83084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="55" mass="6672" checksum="1BC6408C313D1DC6" modified="2009-11-03" version="1">MRFSTIIAVSVLLLSGAYAQDREYSCWGHWDWRHRPDCDRWHGNNWFFKIPTNMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>C8VQK3</accession>
    <name>C8VQK3_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Porphobilinogen deaminase</fullName>
            <ecNumber evidence="5">2.5.1.61</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Hydroxymethylbilane synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Pre-uroporphyrinogen synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">ANIA_00121</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="16">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>4 porphobilinogen + H2O = hydroxymethylbilane + 4 NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:13185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57845"/>
            <dbReference type="ChEBI" id="CHEBI:58126"/>
            <dbReference type="EC" id="2.5.1.61"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>dipyrromethane</name>
            <dbReference type="ChEBI" id="CHEBI:60342"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 2/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HMBS family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.61" evidence="5"/>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF90157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050469325.1">
        <property type="nucleotide sequence ID" value="XM_050611057.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VQK3"/>
    <dbReference type="FunCoup" id="C8VQK3">
        <property type="interactions" value="631"/>
    </dbReference>
    <dbReference type="STRING" id="227321.C8VQK3"/>
    <dbReference type="GeneID" id="2875892"/>
    <dbReference type="KEGG" id="ani:ANIA_00121"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN0121"/>
    <dbReference type="eggNOG" id="KOG2892">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019704_0_2_1"/>
    <dbReference type="InParanoid" id="C8VQK3"/>
    <dbReference type="OMA" id="LWQANHI"/>
    <dbReference type="OrthoDB" id="564646at2759"/>
    <dbReference type="BRENDA" id="2.5.1.61">
        <property type="organism ID" value="517"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00319"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004418">
        <property type="term" value="F:hydroxymethylbilane synthase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006783">
        <property type="term" value="P:heme biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd13645">
        <property type="entry name" value="PBP2_HuPBGD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.40:FF:000002">
        <property type="entry name" value="Porphobilinogen deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000005">
        <property type="entry name" value="Porphobilinogen deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000086">
        <property type="entry name" value="Probable porphobilinogen deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.40">
        <property type="entry name" value="Porphobilinogen deaminase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000860">
        <property type="entry name" value="HemC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022419">
        <property type="entry name" value="Porphobilin_deaminase_cofac_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022417">
        <property type="entry name" value="Porphobilin_deaminase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022418">
        <property type="entry name" value="Porphobilinogen_deaminase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036803">
        <property type="entry name" value="Porphobilinogen_deaminase_C_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00212">
        <property type="entry name" value="hemC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11557">
        <property type="entry name" value="PORPHOBILINOGEN DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11557:SF0">
        <property type="entry name" value="PORPHOBILINOGEN DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01379">
        <property type="entry name" value="Porphobil_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03900">
        <property type="entry name" value="Porphobil_deamC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001438">
        <property type="entry name" value="4pyrrol_synth_OHMeBilane_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00151">
        <property type="entry name" value="PORPHBDMNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54782">
        <property type="entry name" value="Porphobilinogen deaminase (hydroxymethylbilane synthase), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00533">
        <property type="entry name" value="PORPHOBILINOGEN_DEAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="9" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Porphobilinogen deaminase N-terminal" evidence="13">
        <location>
            <begin position="19"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Porphobilinogen deaminase C-terminal" evidence="14">
        <location>
            <begin position="245"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF03900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CBF90157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="347" mass="37580" checksum="3DA4485FE5C55515" modified="2009-11-03" version="1">MTTQTPPPSADPASQKIFTIGTRKSKLALLQTDLVLAALKERFPDYTFKIHSRETAGDQNTTIALRDFTTKNLWTQELEDLLEAGSVDLIVHSLKDVPTLLPTSCTLGPMMKREDSRDGLVIKKGLPNMSLAEMPAGSVVGTSSIRRTAQLARKYPHLKVMDVRGNIGTRLAKLDAEDSPYTCLILAAAGLLRLGLGDRIYQYLDSRNAGMLYAVGQGALGIEIRKGDKAMEDILNTIGHKETTFACLAERSLLRTLEGGCSAPLGVETEWIQDTNGSSKLRMRSVVVSVDGSEHAEVEIDGTVDSPQSAEEFGVTVAKALVNEGAGKILSEIQQNRQLKVPVSEST</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C8VRT4</accession>
    <name>C8VRT4_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Adenosine deaminase, putative (AFU_orthologue AFUA_1G13240)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ANIA_00662</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N(6)-methyl-AMP + H2O + H(+) = IMP + methylamine</text>
            <dbReference type="Rhea" id="RHEA:16001"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:59338"/>
            <dbReference type="ChEBI" id="CHEBI:144842"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:16002"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF89034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050469173.1">
        <property type="nucleotide sequence ID" value="XM_050613349.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VRT4"/>
    <dbReference type="STRING" id="227321.C8VRT4"/>
    <dbReference type="GeneID" id="2876437"/>
    <dbReference type="KEGG" id="ani:ANIA_00662"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN0662"/>
    <dbReference type="eggNOG" id="KOG1097">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039228_3_1_1"/>
    <dbReference type="InParanoid" id="C8VRT4"/>
    <dbReference type="OMA" id="RPQFKPY"/>
    <dbReference type="OrthoDB" id="272271at2759"/>
    <dbReference type="SABIO-RK" id="C8VRT4"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004000">
        <property type="term" value="F:adenosine deaminase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006154">
        <property type="term" value="P:adenosine catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046103">
        <property type="term" value="P:inosine biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000033">
        <property type="entry name" value="Adenosine deaminase-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001365">
        <property type="entry name" value="A_deaminase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006330">
        <property type="entry name" value="Ado/ade_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409">
        <property type="entry name" value="ADENOSINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409:SF42">
        <property type="entry name" value="ADENOSINE DEAMINASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00962">
        <property type="entry name" value="A_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Adenosine deaminase" evidence="9">
        <location>
            <begin position="16"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBF89034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="354" mass="39821" checksum="1B49C44EBF45AB35" modified="2009-11-03" version="1">MDLSKPVDLQFTKSLPKIEVHAHLSGSISRQCLHEIWLQKKARDPTLEIEDPWVVMPLGKVDFSLNTFFGVFNQSIYQLVNDLESVAYATTSVLQAFLDDGVRYLELRTIPRASPNAAFTRDQYLSTVLDTIAEFKSQNSGKISVYLILGMDRGQLVADSTHAHEIVDLAIANRERGVIGVDVCGNPTKGDISLCRDAFAKAKKHGLSLTVHFAEVHSMGLHEELQTMLSFNPDRLGHVIHVPDDIKQEIARKRLGLELCISCNVHAKMFDGGFLDHHFGYWRHEECPVILCTDDVGFFCSPVSNEYLLAAEHFQLNRRDLISISRKAVKAIFGGDEEKQRLWNALDKFESNGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C8VTU4</accession>
    <name>C8VTU4_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acyl CoA binding protein, putative (AFU_orthologue AFUA_1G12300)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ANIA_01062</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF88230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050469069.1">
        <property type="nucleotide sequence ID" value="XM_050613239.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VTU4"/>
    <dbReference type="STRING" id="227321.C8VTU4"/>
    <dbReference type="GeneID" id="2876840"/>
    <dbReference type="KEGG" id="ani:ANIA_01062"/>
    <dbReference type="eggNOG" id="KOG0817">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043304_1_1_1"/>
    <dbReference type="InParanoid" id="C8VTU4"/>
    <dbReference type="OMA" id="WMRRKKD"/>
    <dbReference type="OrthoDB" id="346910at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000062">
        <property type="term" value="F:fatty-acyl-CoA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000582">
        <property type="entry name" value="Acyl-CoA-binding_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035984">
        <property type="entry name" value="Acyl-CoA-binding_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310">
        <property type="entry name" value="ACYL-COA-BINDING PROTEIN, ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310:SF133">
        <property type="entry name" value="COA BINDING PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12300)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00887">
        <property type="entry name" value="ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00689">
        <property type="entry name" value="ACOABINDINGP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47027">
        <property type="entry name" value="Acyl-CoA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51228">
        <property type="entry name" value="ACB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="314"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="ACB" evidence="4">
        <location>
            <begin position="3"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="116"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="156"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="196"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="249"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBF88230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="376" mass="43306" checksum="589340965D643998" modified="2009-11-03" version="1">MILDRVFVHALNTVKRIPRTGTARPPATERLKLYGLYKQSMEGDVEGVMDRPVGNTADVYMEDAWYAQRGLSRTEAKRRYITTLVETMHTYASQTEEARELVAELEFVWNQVKSNIPSSTSSPVQSTGVPPISQPQSPYGSISAQLAQNNEYQYKTSTARGDSRLRVLSPVSQPDDIYQRRTARMGYDRDQGLDQGGDDESVNLDEDEEEEEYAEAQANLYEDDDEVEGEAGGAVDEDDDDDHHHHHQQVYSSHIPDNSPSRKRDHDIDSWRWRRRVEQALTKMTAEIAAAREQMEARTLAARRRSGVWAWLRWLVWVTLRQIIWDLALLGMLLIWMRLRQDRRLEEQLKAGWSVVKARLAGLKALRDLRKVYIFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C8VTZ4</accession>
    <name>C8VTZ4_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carbohydrate kinase PfkB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ANIA_10054</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF89680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050469249.1">
        <property type="nucleotide sequence ID" value="XM_050610971.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VTZ4"/>
    <dbReference type="STRING" id="227321.C8VTZ4"/>
    <dbReference type="GeneID" id="2876119"/>
    <dbReference type="KEGG" id="ani:ANIA_10054"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN10054"/>
    <dbReference type="eggNOG" id="KOG2947">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027634_3_1_1"/>
    <dbReference type="InParanoid" id="C8VTZ4"/>
    <dbReference type="OMA" id="CDYVVFS"/>
    <dbReference type="OrthoDB" id="204058at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004454">
        <property type="term" value="F:ketohexokinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006000">
        <property type="term" value="P:fructose metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070873">
        <property type="term" value="P:regulation of glycogen metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009750">
        <property type="term" value="P:response to fructose"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009749">
        <property type="term" value="P:response to glucose"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032868">
        <property type="term" value="P:response to insulin"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009744">
        <property type="term" value="P:response to sucrose"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010043">
        <property type="term" value="P:response to zinc ion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd01939">
        <property type="entry name" value="Ketohexokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1190.20:FF:000072">
        <property type="entry name" value="AT09463p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052562">
        <property type="entry name" value="Ketohexokinase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034093">
        <property type="entry name" value="KHK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42774:SF3">
        <property type="entry name" value="KETOHEXOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42774">
        <property type="entry name" value="PHOSPHOTRANSFERASE SYSTEM TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="3">
        <location>
            <begin position="3"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBF89680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="317" mass="34951" checksum="05C993BFB4712C26" modified="2009-11-03" version="1">MVLVAVGACYIDTILTTPHYPGEDDKLRATSILRRRGGNCPNTLEVLKQLVPQPSFGQEPPLKLIAVLPAQTSVASKQIRDAFEPQVSLNNCIYRQEFKEPASSYIIKSQASGSRTIVNYNELPEMKLEEFIQIADKLGTEARWFHFEGRIPDVTLSCMRHIREHYPSIKISVEVEKPGREGLQELAQEADVVFYSKSWAQANGYKSAKECIEKQSFQLGKATLLCCTWGQDGAAALEPRVGSAVQSPAYTPKGFQVVDTIGAGDTFIAGMLYGLTVKGDTWDLSQKLSIANRLAGTKVAQEGFDNLGRVLEPLSDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>C8VU88</accession>
    <name>C8VU88_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ANIA_11286</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF88402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3437675_0_0_1"/>
    <dbReference type="InParanoid" id="C8VU88"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF88402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="11" mass="1293" checksum="4DAEF4321045B057" modified="2009-11-03" version="1">MCSLISIERKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2025-10-08" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>C8VUP2</accession>
    <name>C8VUP2_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Choline kinase, putative (AFU_orthologue AFUA_1G15930)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ANIA_00929</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the choline/ethanolamine kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF88506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_658533.2">
        <property type="nucleotide sequence ID" value="XM_653441.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VUP2"/>
    <dbReference type="FunCoup" id="C8VUP2">
        <property type="interactions" value="359"/>
    </dbReference>
    <dbReference type="STRING" id="227321.C8VUP2"/>
    <dbReference type="GeneID" id="2876705"/>
    <dbReference type="KEGG" id="ani:ANIA_00929"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN0929"/>
    <dbReference type="eggNOG" id="KOG2686">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012712_4_0_1"/>
    <dbReference type="InParanoid" id="C8VUP2"/>
    <dbReference type="OMA" id="CEQVINW"/>
    <dbReference type="OrthoDB" id="10267235at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004103">
        <property type="term" value="F:choline kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004305">
        <property type="term" value="F:ethanolamine kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006656">
        <property type="term" value="P:phosphatidylcholine biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd05157">
        <property type="entry name" value="ETNK_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007521">
        <property type="entry name" value="Choline_kin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22603">
        <property type="entry name" value="CHOLINE/ETHANOALAMINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22603:SF93">
        <property type="entry name" value="RE24176P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04428">
        <property type="entry name" value="Choline_kin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01633">
        <property type="entry name" value="Choline_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Choline kinase N-terminal" evidence="3">
        <location>
            <begin position="207"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="19"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="106"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="180"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBF88506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="730" mass="82698" checksum="ED114274B99BCDA9" modified="2009-11-03" version="1">MPSFTEHELQGHYLGVETRLPSAQNPSQDSAATSEANTTRQRRVSVSKVTVRQSFHYPTSAGALNHQVPNANESVTKEDIDRWLKQSEEESRHNLFSQVYEWLSREKSKRKHSNKSNGSTNGSGNGFDGEGDAHGDGAQLTRTVSQGSDTTLALDALEKILLQYASRYDSRTMSTCSSRRSTRRRHPIKGLRRGSVSESDYELDPITPAVDAVLDNSRTLSYTGGGVESEDGDAASITRAKDREAWVVFKSELLRLTHTLQLKGWRKIPMELASEIDVVRLSGALTNAVYKITPPQNIPPPKAEDGSYTLVPRRPPPKLLLRIYGPQVDHLIDREKELQILRRLGRKNIGPKVLGTFNNGRFEEYFEARPLTPKELRDPSTMKQIAKRMRELHDGIDLLDEERENGPMVFHNWDKWVDRCEQVISWVDAEIKSPLNEGKAASEPWRRRGYVCGVPWPKFRKAVEDYRKWLIVDSGGVHEIKRQLVFGHNDTQYGNLLRMEPSQQSPLLLPQNEHKQLVVIDFEYASANTPGLEFANHFTEWCYNYHDAEKPWACNNQLYPTPEQQHQFVTAYLTHRPGLGSRVSPSITPIMRPLSASTPTMTPLDLNATSPDLAPQRPPDNIERSAQDTLEAETQFLIRQTRLWRVLNSAQWVAWGIVQAKVPGMEDDGSSTPTPPVDSDVDESDEFDYLAYAQDRAFFFWADLVALGFVQKEQLPESLAEVVDGRILEY</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1993-10-01" modified="2026-01-28" version="147" xmlns="https://uniprot.org/uniprot">
    <accession>Q03134</accession>
    <accession>C8V0K7</accession>
    <accession>Q5AYV5</accession>
    <name>FDH_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Formate dehydrogenase</fullName>
            <shortName evidence="1">FDH</shortName>
            <ecNumber evidence="1">1.17.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Acetate inducible protein A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">NAD-dependent formate dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">aciA</name>
        <name type="ORF">AN6525</name>
    </gene>
    <organism>
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1992" name="Mol. Gen. Genet." volume="235" first="349" last="358">
            <title>Characterization of the amdA-regulated aciA gene of Aspergillus nidulans.</title>
            <authorList>
                <person name="Saleeba J.A."/>
                <person name="Cobbett C.S."/>
                <person name="Hynes M.J."/>
            </authorList>
            <dbReference type="PubMed" id="1465107"/>
            <dbReference type="DOI" id="10.1007/BF00279380"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the NAD(+)-dependent oxidation of formate to carbon dioxide. Formate oxidation is the final step in the methanol oxidation pathway in methylotrophic microorganisms. Has a role in the detoxification of exogenous formate in non-methylotrophic organisms.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>formate + NAD(+) = CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:15985"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.17.1.9"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="2">Acetate induction mediated by the amdA regulatory gene.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. FDH subfamily.</text>
    </comment>
    <comment type="sequence caution" evidence="4">
        <conflict type="erroneous gene model prediction">
            <sequence resource="EMBL-CDS" id="CAA77687" version="1"/>
        </conflict>
    </comment>
    <comment type="sequence caution" evidence="4">
        <conflict type="erroneous gene model prediction">
            <sequence resource="EMBL-CDS" id="EAA57865" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EC" id="1.17.1.9" evidence="1"/>
    <dbReference type="EMBL" id="Z11612">
        <property type="protein sequence ID" value="CAA77687.1"/>
        <property type="status" value="ALT_SEQ"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AACD01000109">
        <property type="protein sequence ID" value="EAA57865.1"/>
        <property type="status" value="ALT_SEQ"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF70916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="S30088">
        <property type="entry name" value="S30088"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q03134"/>
    <dbReference type="SMR" id="Q03134"/>
    <dbReference type="FunCoup" id="Q03134">
        <property type="interactions" value="441"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q03134"/>
    <dbReference type="EnsemblFungi" id="CBF70916">
        <property type="protein sequence ID" value="CBF70916"/>
        <property type="gene ID" value="ANIA_06525"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AN6525"/>
    <dbReference type="eggNOG" id="KOG0069">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019796_0_0_1"/>
    <dbReference type="InParanoid" id="Q03134"/>
    <dbReference type="OMA" id="HYTDRHR"/>
    <dbReference type="OrthoDB" id="418179at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008863">
        <property type="term" value="F:formate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006083">
        <property type="term" value="P:acetate metabolic process"/>
        <property type="evidence" value="ECO:0000270"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042183">
        <property type="term" value="P:formate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05302">
        <property type="entry name" value="FDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000057">
        <property type="entry name" value="Formate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03210">
        <property type="entry name" value="Formate_dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033689">
        <property type="entry name" value="FDH_NAD-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005750">
        <property type="entry name" value="PRK07574.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42938">
        <property type="entry name" value="FORMATE DEHYDROGENASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42938:SF9">
        <property type="entry name" value="FORMATE DEHYDROGENASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00670">
        <property type="entry name" value="D_2_HYDROXYACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000076024" description="Formate dehydrogenase">
        <location>
            <begin position="1"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="175"/>
            <end position="176"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="231"/>
            <end position="235"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="312"/>
            <end position="315"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="1">
        <location>
            <position position="259"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="1">
        <location>
            <position position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="1465107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="3">
        <source>
            <dbReference type="PubMed" id="1465107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="365" mass="40131" checksum="C9AB2B4EFBFC540D" modified="2011-11-16" version="3">MGKVLMVLYDGGSHAKDQPGLLGTTENELGIRKWIEEQGHTLVTTSDKDGENSTFDKELVDAEVIITTPFHPGYLTAERLAKAKNLKLAVTAGIGSDHVDLDAANKTNGGITVAEVTGSNVVSVAEHVVMTILLLVRNFVPAHDQIRNGDWNVAAVAKNEFDLENKVVGTVGVGRIGERVLRRLKPFDCKELLYYDYQPLRPEVEKEIGARRVDSLEEMVSQCDVVTINCPLHEKTRGLFNKELISKMKPGSWLVNTARGAIVVKEDVAEALKSGHLRGYGGDVWFPQPAPKEHPLRYAEHPWGGGNATVPHMSGTSIDAQIRYANGTKAILDSYFSGRFDYQPQDLIVHGGDYATKAYGQREKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AQB7</accession>
    <accession>C8V4T6</accession>
    <name>Q5AQB7_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Trichothecene 3-O-acetyltransferase-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ANIA_09513</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF75968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_868895.1">
        <property type="nucleotide sequence ID" value="XM_863802.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AQB7"/>
    <dbReference type="GeneID" id="3684112"/>
    <dbReference type="KEGG" id="ani:ANIA_09513"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN9513"/>
    <dbReference type="eggNOG" id="ENOG502SHDQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026450_2_1_1"/>
    <dbReference type="InParanoid" id="Q5AQB7"/>
    <dbReference type="OMA" id="QHNVMFA"/>
    <dbReference type="OrthoDB" id="671439at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051283">
        <property type="entry name" value="Sec_Metabolite_Acyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054710">
        <property type="entry name" value="Tri101-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31896">
        <property type="entry name" value="FAMILY REGULATORY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G14730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31896:SF13">
        <property type="entry name" value="TRICHOTHECENE 3-O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22664">
        <property type="entry name" value="TRI-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Trichothecene 3-O-acetyltransferase-like N-terminal" evidence="3">
        <location>
            <begin position="37"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBF75968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="514" mass="57897" checksum="EE6CC94AA83EA7E2" modified="2005-04-26" version="1">MPESQTYHLHPYGWEDDPEEERFKLSTLDYLSACTYNMYALFFRLDESLSSTAVEALKAGLERTLSQARHLCGTIEKDSDGGHSFTRKKDSTVKFVVQWVDKDPAYPSIDEIEATHFSTVRLGDLKRWSVQPMTYGEKPEAHPDASPAVAAYKANFVRGGLVFIMHHHHYANDVMGWAGLTHQLAENCYAVLNHTPFPLWDPANLDVSRLTKPAPAEEDKVDGPTPPQPTEGQLPRIALLFHLPRSKAAELKRLATPKAADGSWISTYDAFSAFILRTLTRLRAPVYKLDTSKPLFWGEAVDMRRRMHSPPVPARLQGNVMSAAMNINAPAEIAHPTIADIISHADPDGEAEWPLWRLASYIRQLTNSVTQERLDAMLTMVSRVRDKAALKLRIDCQPLMSILQTDHRDANISQADFGFARPITYRHLLDFVTPGLIIIYPPRVGSGPHGDDEGCEFSIVYEQELAQTLIDDPEWNAYFEFRGIDAVDISSTLEVPEYRYPSQHLYVDGSDGYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AQN2</accession>
    <accession>C8VRK1</accession>
    <name>Q5AQN2_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">rRNA processing protein Bystin, putative (AFU_orthologue AFUA_3G04110)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_09398</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bystin family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF87537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_682667.1">
        <property type="nucleotide sequence ID" value="XM_677575.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AQN2"/>
    <dbReference type="FunCoup" id="Q5AQN2">
        <property type="interactions" value="821"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5AQN2"/>
    <dbReference type="GeneID" id="2867835"/>
    <dbReference type="KEGG" id="ani:ANIA_09398"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN9398"/>
    <dbReference type="eggNOG" id="KOG3871">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029727_0_1_1"/>
    <dbReference type="InParanoid" id="Q5AQN2"/>
    <dbReference type="OMA" id="TKLPVIW"/>
    <dbReference type="OrthoDB" id="2192561at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007955">
        <property type="entry name" value="Bystin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12821">
        <property type="entry name" value="BYSTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12821:SF0">
        <property type="entry name" value="BYSTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05291">
        <property type="entry name" value="Bystin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="470"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="42"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="483"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF87537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="492" mass="54862" checksum="030910A2B9FD1AA7" modified="2005-04-26" version="1">MPKVTSARAAAGTRRHNPLAEDIIGTGHLRTAPSKKIKRKSKADGDQEDGERFVDAKTSRKILQIGQELADEDAAEQRAARGVVEEPANRAFDFESRFEDEDVFSDDEGKFNEDQWDDEEDIEEVEVDPNDLDIFHKFVPRGDEDPIFNPSGPETSGQTTNLADLILEKIAEHEAKQAGNTGPIIQGGGLPEDAVQIPAKAVEVYEKVGMILSRYKSGPLPKPFKILPTVPNWQTLLSITRPESWTANAIYAGTRIFISHKPAIAQEFISTVLLERVREEIYEHKKLNVHTYNSMKKALYKPACFFKGLLFPLVSSGTCTLREAHIVSSVIARVSIPVLHSAAALLRMCDLAAEQSMKSLESTGAVNTFIRVFLEKKYALPYKVIDALVFHFLRFRAADPAEDSMTDGPSKAYKLPVLWHQSLLVFAQRYRNDITEDQREALLDLLLVRGHKDIGPEVRRELLAGRGRGIVAPDPERQHALDAGDDTMDTTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AR78</accession>
    <accession>C8VJT4</accession>
    <name>Q5AR78_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribonuclease H1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_09202</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF82335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_682471.1">
        <property type="nucleotide sequence ID" value="XM_677379.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AR78"/>
    <dbReference type="STRING" id="227321.Q5AR78"/>
    <dbReference type="GeneID" id="2867950"/>
    <dbReference type="KEGG" id="ani:ANIA_09202"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN9202"/>
    <dbReference type="eggNOG" id="ENOG502SU8Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1455051_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AR78"/>
    <dbReference type="OMA" id="WGDAHPR"/>
    <dbReference type="OrthoDB" id="407198at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.970.10">
        <property type="entry name" value="Ribonuclease H1, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009027">
        <property type="entry name" value="Ribosomal_bL9/RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011320">
        <property type="entry name" value="RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037056">
        <property type="entry name" value="RNase_H1_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01693">
        <property type="entry name" value="Cauli_VI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55658">
        <property type="entry name" value="L9 N-domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribonuclease H1 N-terminal" evidence="1">
        <location>
            <begin position="6"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="Ribonuclease H1 N-terminal" evidence="1">
        <location>
            <begin position="78"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF82335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="170" mass="19945" checksum="71A6FE5A05673232" modified="2005-04-26" version="1">MSPKNYYAIYKGRVDRPTIVSSWAQAHPRVKEYNGADHEGFDTLEEARNSMQKRGFSEYSEVIKGNQASKTVPRSTERFYAVAYGKSTGVFKDYKDVRKATDYFESACHQRFNTQDEAEEFIEQWRLACSEVWQREIREKLQNGWLLNDLSFNTESILKKEDEGPVLHRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="121" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ARB1</accession>
    <accession>C8VK21</accession>
    <name>Q5ARB1_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ANIA_09169</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF82398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_682438.1">
        <property type="nucleotide sequence ID" value="XM_677346.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ARB1"/>
    <dbReference type="GeneID" id="2867947"/>
    <dbReference type="KEGG" id="ani:ANIA_09169"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN9169"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_3_1"/>
    <dbReference type="InParanoid" id="Q5ARB1"/>
    <dbReference type="OMA" id="WMDYGTS"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000090">
        <property type="entry name" value="MFS sugar transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF28">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="139"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="303"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="333"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="361"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="401"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="427"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="17"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBF82398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="510" mass="56165" checksum="E598D8AE5F58FDDA" modified="2005-04-26" version="1">MHLWKHDFRGRVLVVAIALASCQAFLLLGFDQGVMSGLVGADNRFGRDFDNPDANMQGNITALYDIGCVLGSIVSYFVGERLGRRTMLIAGGGIMVIGTVILASSDTVAQLIVGRIVTGVGNGMNSSTAPVYQSECAPAAYRGALLTLQGTVTILGVVIAYWMDYGPSFTESSLQWRFPLAFQAVFAIFLVLQVIGLPETPRWLVQHDRHEDAREVVAAITDRDVNDPQVVRTVLDIQVGLEEEQKGGPFKFKELFAWGEEQNLRRLLVIISVELGQQFTGSNMINYYGPVMFQTTMNMGRNLSMILGGAIQCTYLVGSAIPVLLMDRFGRRTLLIVCSVGLCFCFVMVSILLSLGSTNAAYGATAFIFIFQIFYGIGWLPVPWFYPSEISTTRTRTRMQAIASAWNWMAVFAVVKITPLAFQNIGWRTFVIFAVLNAAFIPMVYFFYPETKGLELEDIPLLFSKGGFTGGVFSSKGGRTVTPGQHAMQTNVDRKVERMGIELEQVETVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ARK6</accession>
    <accession>C8VH73</accession>
    <name>Q5ARK6_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Conserved glycine-rich protein (AFU_orthologue AFUA_7G02440)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ANIA_09074</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF82602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_682343.1">
        <property type="nucleotide sequence ID" value="XM_677251.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ARK6"/>
    <dbReference type="GeneID" id="2868053"/>
    <dbReference type="KEGG" id="ani:ANIA_09074"/>
    <dbReference type="eggNOG" id="ENOG502S4KZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060392_0_0_1"/>
    <dbReference type="InParanoid" id="Q5ARK6"/>
    <dbReference type="OMA" id="HASGYWV"/>
    <dbReference type="OrthoDB" id="5425547at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056634">
        <property type="entry name" value="DUF7732"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42091">
        <property type="entry name" value="CONSERVED GLYCINE-RICH PROTEIN (AFU_ORTHOLOGUE AFUA_7G02440)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42091:SF1">
        <property type="entry name" value="CONSERVED GLYCINE-RICH PROTEIN (AFU_ORTHOLOGUE AFUA_7G02440)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24866">
        <property type="entry name" value="DUF7732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010321228" evidence="2">
        <location>
            <begin position="20"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7732" evidence="3">
        <location>
            <begin position="120"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBF82602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="257" mass="26305" checksum="499762681192280C" modified="2005-04-26" version="1">MKIALLSAITVLLSTTVTSFTVPTSDITIRHGNLIRSASEPVDLEGRDLEKRRGGGGRGGSGGGSSGGGSGGRGGGGGSSSSSSNHPGTRPGSTSTTSNTGGTSRGGSGTRPTYGRGGGYYGGGATVPYQSGIRSPLGIVPFFLPLAALVAFFPGPWLYGAHIYPYGHPYHYINDTTNKNESMPVICLCAEYSTCGCDDNNNSTYYESLFNGTQPKNGSIVRVTDVNGTQTIAINGTLQNGTTADEDTVDSAAALTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="129" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ARV8</accession>
    <accession>C8VL81</accession>
    <name>Q5ARV8_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ANIA_08972</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF84541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_682241.1">
        <property type="nucleotide sequence ID" value="XM_677149.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ARV8"/>
    <dbReference type="GeneID" id="2868232"/>
    <dbReference type="KEGG" id="ani:ANIA_08972"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_373852_0_0_1"/>
    <dbReference type="InParanoid" id="Q5ARV8"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000061">
        <property type="entry name" value="MFS sugar transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF68">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="269"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="356"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="386"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="543"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="575"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="619"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="641"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="212"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="718"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="733"/>
            <end position="743"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBF84541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="743" mass="82367" checksum="F959BB8BA51D4B73" modified="2005-04-26" version="1">MQSPEPQPCHLPSVTIKPAPSTSPAPIQFGEFPAHSDARTGLSKMHDGGTYSNRPEPLAPTLGLGVDSQIQAATLCSVSSTFLCLSPGRSCSHSQILKTTVSAVGQLGKLDDSCGMYLSREDGRMVAGVWHKESPSPFPNMAQSVLARSQPRRTWPAATVLTGLKESLFDVGRGHDWVPRGLAPAPASGNRYLLARSSGGPPRAVLDLSASSVFVNDYYSELFGYDQGVTGGLLELPSFYKYFPEITADMCPEDENLSSCRSQRSTNQGIAVAAYNLGCFLGAILTVFIGNAIGRRRTIFCGCVTMTTGAILQCTAYSLPHWIVGRIVTGIGNGMNTSTVPTWQSESAKAHDRGKLVMIEGMLITGGICLSYWINYGFAFLPDHEVSWRFPIAFQIIFAVTIFISIMNLPESPRWLVMKGRDDEAVEILELLNEKPRDDPYIQNELLSIKETVMEMNKGSFRSLFKMSEYREFHRVALAYVNQMFQQISGINLITYYAPNIYTDIGLGGGNTAKLMAAANGTEYLLAAFIPIFIIEKVGRRPLMLFGAAGMSISMAILAGTHYRRETYDDTKAGVAQAVFLFVFNTFFAIGWLGMTWLYPAEIVPLRIRAPTNALSTSANWIFNFMVVMITPVAFENIKHNTYTIFAVINAFMFPVVYFCFPETRYRSLEEMDAIFKKSDGIWSAVQHSIKEPYRYDKHGQLKPEYLEEAIRRESVRHVEGKFESEDSTNESQEAKGTETRLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AS13</accession>
    <accession>C8VLJ6</accession>
    <name>Q5AS13_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DUF636 domain protein (AFU_orthologue AFUA_2G12650)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ANIA_08917</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF84664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_682186.1">
        <property type="nucleotide sequence ID" value="XM_677094.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AS13"/>
    <dbReference type="GeneID" id="2868213"/>
    <dbReference type="KEGG" id="ani:ANIA_08917"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN8917"/>
    <dbReference type="eggNOG" id="ENOG502SH4K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038839_1_0_1"/>
    <dbReference type="InParanoid" id="Q5AS13"/>
    <dbReference type="OMA" id="WADSGKR"/>
    <dbReference type="OrthoDB" id="5422068at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1590.10">
        <property type="entry name" value="glutathione-dependent formaldehyde- activating enzyme (gfa)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337:SF31">
        <property type="entry name" value="DUF636 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_2G12650)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337">
        <property type="entry name" value="GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="5">
        <location>
            <begin position="6"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBF84664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="361" mass="39400" checksum="C298700572321E23" modified="2005-04-26" version="1">MSTKTLTIRCHCRSTHFALTVEPTSLPLRAHLCHCTLCRTTHGTTASYHAPLPEGVKPSFIAPSSWDNLTAYTPPGSGAKLYFCSTCGCQVGGTNVLGIWDTVVSIIEGGNEEDAIWVIDEHIYTEKGSTGDGGIAELLPRIGERELRVWNPDIKGTEFPTAGSGAAGRSASHNRQDDKLLAQCNCGGVSFTISRPREDFMNSPLSKGWIHPSFRTKWLALLDVCDDCRLLTGAHVTTWLFVPIDHITPSLPDDLVIGTMKRYESTPGTVSRTFCGTCGATVFCYYDKRGGIVDIATGILRAPEGVMLGDWAVWRTAKLGFKDDGRRYDKLFTEGLEKGAKEWGRRVHGEVIDFQGGPATD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AT17</accession>
    <accession>C8VET4</accession>
    <name>Q5AT17_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Kinesin light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ANIA_08563</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF80807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_681832.1">
        <property type="nucleotide sequence ID" value="XM_676740.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AT17"/>
    <dbReference type="STRING" id="227321.Q5AT17"/>
    <dbReference type="GeneID" id="2868644"/>
    <dbReference type="KEGG" id="ani:ANIA_08563"/>
    <dbReference type="eggNOG" id="KOG1840">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1343223_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AT17"/>
    <dbReference type="OMA" id="ALMERCV"/>
    <dbReference type="OrthoDB" id="5986190at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005871">
        <property type="term" value="C:kinesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002151">
        <property type="entry name" value="Kinesin_light"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45783">
        <property type="entry name" value="KINESIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45783:SF3">
        <property type="entry name" value="KINESIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0802">TPR repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="19"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="30"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBF80807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="204" mass="23633" checksum="2954733F1D65A9FB" modified="2005-04-26" version="1">MCRCRGRYKRYKEAAAITESLLSKQRAGEEEVEEEEEEEEEEEEEEEDDDDDNDANTSTLISLSDLAITYQRQGRWKEAEELNVQVFELRKKFLGSEHPDTLMLGPEHPDTLASMANLACTYGSQGQWLEAEELQVRVLKMRKQVLCPQHPDTLQSMNNLAHTWHSERKVHDALALMERCVELRIRVLGYSHPASESSSFYLRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ATR2</accession>
    <accession>C8VE08</accession>
    <name>Q5ATR2_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter, putative (AFU_orthologue AFUA_1G17530)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ANIA_08318</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF80296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_681587.1">
        <property type="nucleotide sequence ID" value="XM_676495.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ATR2"/>
    <dbReference type="GeneID" id="2868753"/>
    <dbReference type="KEGG" id="ani:ANIA_08318"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_0_5_1"/>
    <dbReference type="InParanoid" id="Q5ATR2"/>
    <dbReference type="OMA" id="THSEQVF"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000556">
        <property type="entry name" value="MFS transporter, putative (AFU_orthologue AFUA_1G17530)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF74">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17530)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="298"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="336"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="369"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="436"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="465"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="475"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBF80296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="492" mass="55019" checksum="F6D9BE220F63B576" modified="2005-04-26" version="1">MSSDPKVTAEHSECVDMSVKDGSVESCAGMSPRAPVLDDEKNRKLLRKIDMHLMPVVRSLALDCAPDRRRSRPQMCFTYALQYYDKALLSQAAIFGLRTDLGIEDGLKYSWVSLIFYFGYIAGCYPISWLSQKFTVGKVCPIICFLWAVVVLTTPACTNYTGMLVNRFMLGLIESGVSPAFMLCTGMWYTHSEQVFRSSLWYSFIGGSNIVSPLINYGLSHITGGVLHPWQYMYLIAGLATLLWSIILWFVFPGSPHIAKGFSAEERIMVLERVRSNNAGAENRHFKWYQVREALLSYQFWFVFVLSLLSSIGRGAVTTFGSIIFNGMGFSTFQSLLLNMPIGALAFICVLGSGYIGRKVPNSRLYIRAARIIGFYLINFFSSAWVQCIAMGTSNVAGHTKKATMAAATFMGYSLGNIVGPLTFDANDAPRYDPGFRATVICFAICFVLAQVFRALMLAQNKRRNSKYGPPTQEHGLEDLTDRENKSFRYPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="107" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AU51</accession>
    <accession>C8V6Z4</accession>
    <name>Q5AU51_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DnaJ domain protein (AFU_orthologue AFUA_5G03040)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ANIA_08179</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF74048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_681448.1">
        <property type="nucleotide sequence ID" value="XM_676356.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AU51"/>
    <dbReference type="STRING" id="227321.Q5AU51"/>
    <dbReference type="GeneID" id="2869023"/>
    <dbReference type="KEGG" id="ani:ANIA_08179"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN8179"/>
    <dbReference type="eggNOG" id="KOG0718">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019611_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AU51"/>
    <dbReference type="OMA" id="QLDKHTM"/>
    <dbReference type="OrthoDB" id="666364at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042407">
        <property type="term" value="P:cristae formation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="DnaJ-like_C11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
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    <dbReference type="InterPro" id="IPR055225">
        <property type="entry name" value="DNAJC11-like_beta-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052243">
        <property type="entry name" value="Mito_inner_membrane_organizer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44157">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44157:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 11"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF11875">
        <property type="entry name" value="DnaJ-like_C11_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22774">
        <property type="entry name" value="DNAJC11_beta-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="5">
        <location>
            <begin position="21"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="199"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="204"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBF74048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="748" mass="83560" checksum="86EC205B74B2FDF0" modified="2005-04-26" version="1">MNNNSKQIPVGDADTDNNEAETYSLLMSYPEELDSLCRPWSSPRPSAYRRRNPLRLPDAHDAAKQQFERIREAYDTLIDPKKRVVYDLLGAEGVRREWGVHGAMGRGGEAERQEKQGQVGVKTMKPEEFRRWFLESMKNRERAVLNSLVRSKGSLIVGVDARDMISVNEREGEVYLEIPSAKLSSFAVRYSFVTPFPTLRTGMGEDEREGAESEVGEEEEQKASQSPELEIYAGVAGGFQRLFNKVELEWEDGETELREVPLPLILSTQNVTLGASTSRVLSDPNPKGILKRWPFSLFQDTLVSVEATALPSTTVQANVAKSIVVTPGTRPFNVILGTIFNRSIFQAPPMLNLQVTKGIGQKKTAFCSWSSGFIGWPSFIETLLLPFAGDSLSLEDQAISQLQVGIASQLAKLAPGLADEDEDMPESAEDDEEEDEFEMLRAKKREEQKAAEAWHVAISASPATAGIIFKYSRNIFSGKPATDAALSQWSSEKHYSLPPANEPRSVRLEITSTVDMNLSLRWSVHGSRQVSELTRVGFGVSLQPQGLIMSLSWARLGQRIRLPIAICPIDSVNADSATLAVLLPWLTYCAVEFGFIRPRERRNRRKLIAKRQKKLRKLVPQKRLESTQAIELMADQVRRRQDKEYSRGGLVITKAEYGHYPSKRNADKGAKEPEVTDVTIPVAALVDHGQLIISKKTAKFQILGFHDPAPLLPKTLKIWYQYHGKEHYAEATDAEGVTCPMRSHLLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AU70</accession>
    <accession>C8V6X1</accession>
    <name>Q5AU70_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ANIA_08160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF74006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_681429.1">
        <property type="nucleotide sequence ID" value="XM_676337.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AU70"/>
    <dbReference type="GeneID" id="2869243"/>
    <dbReference type="KEGG" id="ani:ANIA_08160"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN8160"/>
    <dbReference type="HOGENOM" id="CLU_1390215_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AU70"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF74006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="196" mass="22032" checksum="5A7CEBD0AEE322B6" modified="2005-04-26" version="1">MTELRLLLDIFRVIEVVTVSCRALLVSLSLKYLAASLAAGVDGSSYLDVPYVQEGIAKEEMRKKDCCCKEVYIGISSKKLRSKAAIKAMTTLNILAKCYSKYIFNPFWLFNKCYGSFAYTRTLDLSDSAKACAVLKAVSHLQDFLATTILLSHFFFSDSFLVIQGDISLYSLLEYLGRNWLDLVFFLNNPGPKVLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="116" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AU87</accession>
    <accession>C8V6V1</accession>
    <name>Q5AU87_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">(2E,6E)-farnesyl diphosphate synthase</fullName>
            <ecNumber evidence="6">2.5.1.1</ecNumber>
            <ecNumber evidence="5">2.5.1.10</ecNumber>
            <ecNumber evidence="4">2.5.1.29</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Dimethylallyltranstransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Farnesyl diphosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Farnesyltranstransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Geranylgeranyl diphosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Geranyltranstransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">ANIA_08143</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="21">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>isopentenyl diphosphate + (2E)-geranyl diphosphate = (2E,6E)-farnesyl diphosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19361"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58057"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
            <dbReference type="EC" id="2.5.1.10"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>isopentenyl diphosphate + (2E,6E)-farnesyl diphosphate = (2E,6E,10E)-geranylgeranyl diphosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:17653"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58756"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
            <dbReference type="EC" id="2.5.1.29"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>isopentenyl diphosphate + dimethylallyl diphosphate = (2E)-geranyl diphosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22408"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
            <dbReference type="ChEBI" id="CHEBI:58057"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="EC" id="2.5.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis; terpenoid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 19">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.1" evidence="6"/>
    <dbReference type="EC" id="2.5.1.10" evidence="5"/>
    <dbReference type="EC" id="2.5.1.29" evidence="4"/>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF73971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_681412.1">
        <property type="nucleotide sequence ID" value="XM_676320.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AU87"/>
    <dbReference type="FunCoup" id="Q5AU87">
        <property type="interactions" value="451"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5AU87"/>
    <dbReference type="GeneID" id="2868962"/>
    <dbReference type="KEGG" id="ani:ANIA_08143"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN8143"/>
    <dbReference type="eggNOG" id="KOG0777">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014015_6_0_1"/>
    <dbReference type="InParanoid" id="Q5AU87"/>
    <dbReference type="OMA" id="ANFAYFW"/>
    <dbReference type="OrthoDB" id="6921389at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004337">
        <property type="term" value="F:(2E,6E)-farnesyl diphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004161">
        <property type="term" value="F:dimethylallyltranstransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004311">
        <property type="term" value="F:geranylgeranyl diphosphate synthase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046165">
        <property type="term" value="P:alcohol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001">
        <property type="entry name" value="GERANYLGERANYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001:SF70">
        <property type="entry name" value="PYROPHOSPHATE SYNTHETASE ATMG, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G02400)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 19" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00033096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00049399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CBF73971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="355" mass="40105" checksum="922EC2C04430CCD9" modified="2005-04-26" version="1">MVFDTLNAPQPYQEHYPPRWNVHHSSSPLPNGHSIIPNGHSIIPNGKTAVAVTNGADNQHQHKGKEEEIISAPVHYISTLPGKDIRGKLISAFNEWFQIPDEQLEIIKRAVGLLHVASLLIDDIEDYSKLRRGFPVAHSIFGIPQTINSANYAYFQAQNEVLKLRRCEKALRIFTEELLRLHRGQGMDLYWRDSLTCPSEEEYLDMVANKTGGLFRLAIKLIQLESDVDEFIRDDYQNLQSDQYAKNKGFGEDITEGKFSYPIVHSIRSSSRTGVGSDSSLQLLSILRQKTEDEAVKKYTIQILEKTGSFEFTRQKLRDLTARARDMLTELRERAGAGAGAAGLLGILDFLELKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AUA3</accession>
    <accession>C8V6N9</accession>
    <name>Q5AUA3_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">MFS transporter, putative (AFU_orthologue AFUA_1G17480)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ANIA_08127</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF73940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_681396.1">
        <property type="nucleotide sequence ID" value="XM_676304.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AUA3"/>
    <dbReference type="GeneID" id="2869104"/>
    <dbReference type="KEGG" id="ani:ANIA_08127"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN8127"/>
    <dbReference type="eggNOG" id="KOG3098">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030884_1_0_1"/>
    <dbReference type="InParanoid" id="Q5AUA3"/>
    <dbReference type="OMA" id="FCYWLMG"/>
    <dbReference type="OrthoDB" id="196103at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051617">
        <property type="entry name" value="UNC-93-like_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294">
        <property type="entry name" value="ET TRANSLATION PRODUCT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294:SF55">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17480)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="195"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="255"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="293"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="324"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBF73940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="482" mass="52093" checksum="20AD7BD486392A74" modified="2005-04-26" version="1">MDQKAQPEAEDGRTVAAGQEERSIVYRTYTHPWFQIFLISFICFCCPGMYNALTGLGGSGQVDPTVAANATVALLSATAGTALFVVGPIFDRVGPRICLLFGGWTYPLYAGSLLCFNRTGNGAFVIASGAILGIGASFLWVSQGAIMTTYVRESQKGRAIAAFWIIFNLGGGVGSLASFGLNYHSTSGTVSDGTYIALLILMAVGWLLGMLICPPSAVRLEELQQSSRTQTAVVETEKPNWKSTLRLAARTILDWRVLCMLPLFFCANVFYSYQQNIVNGMTFNIRTRSLNSALYWLAQMLGGLVMGLILDIPALTRPGRARAGWLFLAVTGLAIWGGGYAFEKWSSDRLAHGLKQDIDYTQGTVSTGPIFLYIFYGAFDAFWQSYCYWLMGARSNDPAVAAVLVGAYKTFQSTGGAMAWRINALDKPAMTQFAMDWGLCMGALVVAIPAVLTVTKTSTVDAEVAHQGEKGEEKTMSASVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="104" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AUB1</accession>
    <accession>C8V6N0</accession>
    <name>Q5AUB1_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alpha-1,2-mannosyltransferase (Ktr4), putative (AFU_orthologue AFUA_5G02740)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ANIA_08119</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 15 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF73924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_681388.1">
        <property type="nucleotide sequence ID" value="XM_676296.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AUB1"/>
    <dbReference type="CAZy" id="GT15">
        <property type="family name" value="Glycosyltransferase Family 15"/>
    </dbReference>
    <dbReference type="GeneID" id="2869186"/>
    <dbReference type="KEGG" id="ani:ANIA_08119"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN8119"/>
    <dbReference type="eggNOG" id="KOG4472">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024327_4_3_1"/>
    <dbReference type="InParanoid" id="Q5AUB1"/>
    <dbReference type="OMA" id="WCFFLYQ"/>
    <dbReference type="OrthoDB" id="439943at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000032">
        <property type="term" value="P:cell wall mannoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000051">
        <property type="entry name" value="Alpha-1,2-mannosyltransferase (Ktr4)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002685">
        <property type="entry name" value="Glyco_trans_15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121">
        <property type="entry name" value="ALPHA-1,2 MANNOSYLTRANSFERASE KTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121:SF7">
        <property type="entry name" value="MANNOSYLTRANSFERASE KTR4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01793">
        <property type="entry name" value="Glyco_transf_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010164930" evidence="4">
        <location>
            <begin position="29"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBF73924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="395" mass="46294" checksum="0250714BF5D80DA0" modified="2005-04-26" version="1">MAVARPIRMLSAACVVLVIFLVFQMKRSPSYVGMGPGEYNGMTADPLNDPTGEPDGYLWRADEHDYAPDSTNSARTNAAIISLVRNEELNELLPSMRDLERTWNHKFNYPWIFFNDVPFTEEFKKRTQAETKAKCQYELVPKEHWEVPSFIDMNLFKESAALLKEKGLQYADKISYHQMCRWNSGMFYKHPALKDYRYYWRVEPKVQFFCDVDYDVFRFMEDRNKTYGFTINLFDAPESIPSLWPTTQEFLAANPSYLSDNNMMDWLTDDQLRPDHTRDANGYSTCHFWSNFEIGDMEFFRGDKYSAYFDFLDHAGGFFYERWGDAPVHSIGLGLFEDKNKVHWFRDIGYRHIPYFNCPNSPKCSACTPGKFYEGASFLAKEDCRPSYFKHVGTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="107" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AUD0</accession>
    <accession>C8V6L0</accession>
    <name>Q5AUD0_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Sodium ion/proton exchanger (Eurofung)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">ANIA_08100</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF73888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_681369.1">
        <property type="nucleotide sequence ID" value="XM_676277.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AUD0"/>
    <dbReference type="STRING" id="227321.Q5AUD0"/>
    <dbReference type="GeneID" id="2869217"/>
    <dbReference type="KEGG" id="ani:ANIA_08100"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN8100"/>
    <dbReference type="eggNOG" id="KOG1650">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024407_1_0_1"/>
    <dbReference type="InParanoid" id="Q5AUD0"/>
    <dbReference type="OMA" id="TWAITLC"/>
    <dbReference type="OrthoDB" id="1288932at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43562">
        <property type="entry name" value="NAPA-TYPE SODIUM/HYDROGEN ANTIPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43562:SF3">
        <property type="entry name" value="SODIUM ION_PROTON EXCHANGER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0050">Antiport</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0915">Sodium</keyword>
    <keyword evidence="9" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="198"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="240"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="336"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="367"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="535"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="12">
        <location>
            <begin position="40"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="292"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="416"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="292"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="419"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="468"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CBF73888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="583" mass="62443" checksum="37BBB04709B9E48B" modified="2005-04-26" version="1">MADSAFAYHEPSISTILNQTGLLLVLNIVNTCLDKLLYCGLIGQLFVGILWGTPGAQWLDRSVETVIQQLGYLGLIMLVYEGGLSTSLSSLRANMYLSVAVAFTGIGIPMALSFVLMELVSATPLQAFAAGAALSATSLGTTFTILSTTGLITTRLGTVTTSAAMLDDVVGLVMVQIISNLGGSGNSFSALTVVRPLFVSLGLGVGVVLACRFVLRPFLMRVLPSRDRLPGFTSTPQFAFLRYTGLLVGLVAGATYAGTSSLLAAYLAGVISSWFDGLLRAMPVSTAESSSFRQEASPQPASRDSSVTHSPRSPEPGQEREQITGMHIYEHYYQGPVNRILTPMFFASIGFAIPITEMFQGSVVWRGFVYALLMTFGKMCTGLWLVRGSPVSGLTTFARILKASLSYVTSCLRRPLKSQSEKSPHAQQAQHREPVQNTDGAPQEPSDNRSARVGSNNQKEGEYATNTDSDRPPQREPDQRTPFVSSLPPKPKSLYPATILSLAMVARGEIGYLIASLAESNGIFGKDSQGSSETYLVVVWAISLCTLIGPISVGTLVKRVKILQRQRENSNTGGADPLGVWGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AUE2</accession>
    <accession>C8V6F0</accession>
    <name>Q5AUE2_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">C6 transcription factor, putative (AFU_orthologue AFUA_7G00410)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ANIA_08088</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF73860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_681357.1">
        <property type="nucleotide sequence ID" value="XM_676265.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AUE2"/>
    <dbReference type="GeneID" id="2868950"/>
    <dbReference type="KEGG" id="ani:ANIA_08088"/>
    <dbReference type="eggNOG" id="ENOG502RPVK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024404_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AUE2"/>
    <dbReference type="OMA" id="FDFLPMM"/>
    <dbReference type="OrthoDB" id="4454541at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF38">
        <property type="entry name" value="TRANSCRIPTION FACTOR, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G00410)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="501"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="502"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBF73860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="593" mass="67249" checksum="064C4313DBAF21E2" modified="2005-04-26" version="1">MPALICPARAVAQQDHAQRSGEGMRIRHGKLLFPGGRSATADRQYWDSQRSSFDTGLGVSPRSNISVPSNHLENIELQQFSPQDMIAPQSVMHSMSVNMREDSPIFLGDSDVSDPKGDIISRGIISEEDARCIYERFMNCSKNFLPLFDPVRDTFDSIRSRSLFCFTVIIYLASRAASDFRADTHLQRVLQDEAQRLAEDSFFAKPTKLETVQGMILLAAYSEKTWFSTALILRTALDLGLEKSLDTLLAQSSPPRSYLSARMEDRQLVWQTRTWLISSTLELDVASGTGRKSRLGDVDISKLRKFLDYPLSLHSDMRTVSIIEYHQIRTRGRQIIENSAAAPIIHTELPAIMRKLQQWWEEWDELHHPRIQKLQQTPEGDQGISSDAVLGLWKSLVEVIESQLTLLVTESAYRCQLVWAPTYPALTIAFITTFAIRVARWHPTLINRRLVLQRVRQILEYLKQPPYPDIHRTVQIFVNYAGALLAEQDLCNDHGQAIAAQPSRTPEVNSTPRSEFTTSIPEQAAENPMIRMDKDTDLTAPLPSESRPEPVLPRLLGFDIPNWNLTAPIADSFDLFEEGQTDIFDFLPDLCRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AUM0</accession>
    <accession>C8V5S6</accession>
    <name>Q5AUM0_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glycogen [starch] synthase</fullName>
            <ecNumber evidence="8">2.4.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ANIA_08010</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Glycogen synthase participates in the glycogen biosynthetic process along with glycogenin and glycogen branching enzyme. Extends the primer composed of a few glucose units formed by glycogenin by adding new glucose units to it. In this context, glycogen synthase transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan.</text>
    </comment>
    <comment type="function">
        <text evidence="8">Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + UDP-alpha-D-glucose = [(1-&gt;4)-alpha-D-glucosyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18549"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:9587"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.11"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:18550"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Glycan biosynthesis; glycogen biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyltransferase 3 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.11" evidence="8"/>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF73699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_681279.1">
        <property type="nucleotide sequence ID" value="XM_676187.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AUM0"/>
    <dbReference type="FunCoup" id="Q5AUM0">
        <property type="interactions" value="429"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5AUM0"/>
    <dbReference type="CAZy" id="GT3">
        <property type="family name" value="Glycosyltransferase Family 3"/>
    </dbReference>
    <dbReference type="GeneID" id="2869281"/>
    <dbReference type="KEGG" id="ani:ANIA_08010"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN8010"/>
    <dbReference type="eggNOG" id="KOG3742">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015910_1_0_1"/>
    <dbReference type="InParanoid" id="Q5AUM0"/>
    <dbReference type="OMA" id="RDVRNHI"/>
    <dbReference type="OrthoDB" id="6335297at2759"/>
    <dbReference type="UniPathway" id="UPA00164"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004373">
        <property type="term" value="F:alpha-1,4-glucan glucosyltransferase (UDP-glucose donor) activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd03793">
        <property type="entry name" value="GT3_GSY2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000014">
        <property type="entry name" value="Glycogen [starch] synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000045">
        <property type="entry name" value="Glycogen [starch] synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008631">
        <property type="entry name" value="Glycogen_synth"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10176:SF3">
        <property type="entry name" value="GLYCOGEN [STARCH] SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10176">
        <property type="entry name" value="GLYCOGEN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05693">
        <property type="entry name" value="Glycogen_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="3 8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="629"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="680"/>
            <end position="711"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00043883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBF73699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="711" mass="81157" checksum="27C7B3844D9C8D2E" modified="2005-04-26" version="1">MADDQDPPRRDVRNHMLFEIATEVANRVGGIYSVLKSKAPVTTAEYGERYTLIGPLNRNSAAVEVEELTPSSPAMKETMQSMKERGIEMVYGRWLIEGAPRVLLIDTGTGYKYLDEWKGDLWNTAGIPSPASDHETNEAIVFGYLVAWFLGEYIAHERRRAVVAHFHEWLAGVALPLTKKRHMDLTTIFTTHATLLGRYLCAGSVDFYNNLQYFDVDAEAGKRGIYHRYCIERAAAHSADVFTTVSHITAFESEHLLKRKPDGVLPNGLNVKKFSAVHEFQNLHSQSKEKINEFVRGHFYGHNDFDFDDTLYVFTSGRYEFRNKGVDMFIEGLARLNHRLKSSGSKTTVVAFIIMPAQTSSLTVESLKGQAVVKSLRDTIHMIEQGIGKRMYERCLAWKEGDNMPDEKDLITSQDRVLLRRRLFAMKRHTLPPIVTHNMINDSEDPILNQIRRVQLFNQSSDRVKIVFHPEFLNSSNPVLPLDYDDFVRGTHLGVFPSYYEPWGYTPAECTVMGVPSITTNLSGFGCYMEELIENSSDYGIYIVDRRMKGVDDSVNQLTDFMYNFTLKSRRQRINQRNRTERLSDLLDWKRMGLEYVKARQLALRRAYPSSFDNQEDYFDVIGGTEQKISRPLSVPGSPRDRSGMMTPGDFASLQEVKEGLSTEDYVAWRLPTSEEDDAEDHFYPLTLRTKKSDRPSSPLDRISINGGQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AUR2</accession>
    <accession>C8V5E5</accession>
    <name>Q5AUR2_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ANIA_07968</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF73616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_681237.1">
        <property type="nucleotide sequence ID" value="XM_676145.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AUR2"/>
    <dbReference type="GeneID" id="2869270"/>
    <dbReference type="KEGG" id="ani:ANIA_07968"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN7968"/>
    <dbReference type="eggNOG" id="ENOG502SJME">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1768029_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AUR2"/>
    <dbReference type="OMA" id="PRVEHAH"/>
    <dbReference type="OrthoDB" id="5415741at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF73616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="147" mass="16831" checksum="7F612EE118BDBEB6" modified="2005-04-26" version="1">MPAPHPNELRVQVLSYWALGIQPPDIAKMLQINVRTIRDMIQKGQDRGYNPAQCMRVKLEYVEDGKRSGRPKDISEATDMAVLASVKQDRNRREKSSEILAFEAAAKATRLRFCLDHQHWTLEDWKAVIFTDETSVILGHRQGSCKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AVA6</accession>
    <accession>C8VDP3</accession>
    <name>Q5AVA6_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Integral membrane protein Pth11-like, putative (AFU_orthologue AFUA_7G06620)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ANIA_07774</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF80080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_681043.1">
        <property type="nucleotide sequence ID" value="XM_675951.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AVA6"/>
    <dbReference type="GeneID" id="2869612"/>
    <dbReference type="KEGG" id="ani:ANIA_07774"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN7774"/>
    <dbReference type="eggNOG" id="ENOG502R3ID">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028200_0_2_1"/>
    <dbReference type="InParanoid" id="Q5AVA6"/>
    <dbReference type="OMA" id="CLTSWAF"/>
    <dbReference type="OrthoDB" id="444631at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF114">
        <property type="entry name" value="MEMBRANE PROTEIN PTH11-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G06620)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="160"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="197"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="231"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="26"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBF80080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="348" mass="38633" checksum="753AE6D53AA9C6E8" modified="2005-04-26" version="1">MVETQGPTVTGIALAFAIITVFVILLRLFARLYVLKKFDVDDALIIFACGFSWAFSAVTIVAVKHGLGMHLDDVDPSNMVTYAFNVWLSSMFYLSCLGFVKTSVCWFYTRLGDKYLRRMSYIMFGIVACQAIANVCTAAFQCRPISKAWDTTLKGTCVNINVFYLANAALNILTDLLTYTLPVRVIFKLQMPRKQKIALVFILCLGLFACVSSIVRITYIPTMLSSDDATWAISGAMYWSAIEINVGILAASIPSFKAIASRFLPRLIGEYSSNKAYNYAYGAGSGFSKVRDPSRNQSVHMHSLRGRANDHTVIGTGNLSGIDRSSEERIFVPEGKIYAHTEIEVRQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="112" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AVJ6</accession>
    <accession>C8VC42</accession>
    <name>Q5AVJ6_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Monooxygenase, putative (AFU_orthologue AFUA_2G01680)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ANIA_07684</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF79896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_680953.1">
        <property type="nucleotide sequence ID" value="XM_675861.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AVJ6"/>
    <dbReference type="STRING" id="227321.Q5AVJ6"/>
    <dbReference type="GeneID" id="2869665"/>
    <dbReference type="KEGG" id="ani:ANIA_07684"/>
    <dbReference type="eggNOG" id="KOG2614">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009665_19_3_1"/>
    <dbReference type="InParanoid" id="Q5AVJ6"/>
    <dbReference type="OMA" id="QRHDFHM"/>
    <dbReference type="OrthoDB" id="16820at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000115">
        <property type="entry name" value="Salicylate hydroxylase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF238">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_2G01680)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="480"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="7">
        <location>
            <begin position="51"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="7">
        <location>
            <begin position="331"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBF79896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="506" mass="55804" checksum="F2280F861117B380" modified="2005-04-26" version="1">MPVTGKLDKLIAGSGIIDSKYTPGYPGRSPPIGAHCHVYPGYPGYQMTSLNILVVGAGLSGLATAISCAQSGHTVTVLEQAAELAEVGAGLQVTPNASRLFNHWGLRQSLWREAPEPKTLTVHRYTGDVLAHDAFFDKHIRQRYGAPFVDVHRVDLQQALYARAKELGIVVVLAERVKSILDARDAETSTATVLTESGKTYTADLVVAADGLWSRCRECLLNRKDEPLPTGDLAYRIVLHIDQISDPKLRAFVQNPQVHFWIGPGAHVVSYSMRGGDMINIVLLVPDNLPPGVSREAGSVEEMRGLFKGWDPVLITADAEMETWINPSSTLVFVGDACHPMLPYLAQGANSSLEDGAVLGGLLGHLRHKSQLPQILKLYESLRKNRGEAIVRETFKQRHDFHLPDGEQQEKRDALFKSQLGKEEIDPDTAFPSRWTCPKVQPWLYGYDAVREVENAVKANPDIFGDSGYKKDVNVEGQKLWSWAGLSSYLPFYLPILLFGVGKFVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AVM6</accession>
    <accession>C8VC07</accession>
    <name>Q5AVM6_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GPI anchored cell wall protein (Dan4), putative (AFU_orthologue AFUA_2G01140)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_07654</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF79832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_680923.1">
        <property type="nucleotide sequence ID" value="XM_675831.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AVM6"/>
    <dbReference type="STRING" id="227321.Q5AVM6"/>
    <dbReference type="GeneID" id="2869454"/>
    <dbReference type="KEGG" id="ani:ANIA_07654"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN7654"/>
    <dbReference type="HOGENOM" id="CLU_946745_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AVM6"/>
    <dbReference type="OMA" id="GTHHASD"/>
    <dbReference type="OrthoDB" id="4510264at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010186610" evidence="2">
        <location>
            <begin position="23"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="91"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF79832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="294" mass="30328" checksum="47A763AD9DEEC6A3" modified="2005-04-26" version="1">MAVMSRIVQILCVSLLATSTFAAPAPERASLERGTISRVEVREIVEHVDEKLIQSLADKLRTARPDLKDRDFAIANGLSFVKRQEASPGASDTVTDSPTSTESTETSDPTSTSDTETSTDTEPTSSEPTSTDTTVTSTSSSSEPTSTDTDTTTSSDTSSSATTSETSATTTSDTPTSTTEGETSTSSTDERTSTSTSSESTETSSSTSSDEPTTTFSTTSASEVTSTYTRTSTNAEGELVTVTETAIVHPTQSSTDEATTTGPEPGLQTNGAASAFAKELFAMMGGAALAVAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AVV2</accession>
    <accession>C8VBR6</accession>
    <name>Q5AVV2_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Borealin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">ANIA_07578</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the borealin family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF79665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_680847.1">
        <property type="nucleotide sequence ID" value="XM_675755.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AVV2"/>
    <dbReference type="STRING" id="227321.Q5AVV2"/>
    <dbReference type="GeneID" id="2869513"/>
    <dbReference type="KEGG" id="ani:ANIA_07578"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN7578"/>
    <dbReference type="eggNOG" id="ENOG502S9QE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038589_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AVV2"/>
    <dbReference type="OMA" id="ITMQQKQ"/>
    <dbReference type="OrthoDB" id="2392550at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032133">
        <property type="term" value="C:chromosome passenger complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051233">
        <property type="term" value="C:spindle midzone"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018851">
        <property type="entry name" value="Borealin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018867">
        <property type="entry name" value="Cell_div_borealin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16040">
        <property type="entry name" value="AUSTRALIN, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16040:SF7">
        <property type="entry name" value="AUSTRALIN, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10444">
        <property type="entry name" value="Nbl1_Borealin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="9" id="KW-0137">Centromere</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Borealin N-terminal" evidence="11">
        <location>
            <begin position="39"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="102"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="203"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="229"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="245"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="302"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF10444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CBF79665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="376" mass="40507" checksum="83999B658C61D8FE" modified="2005-04-26" version="1">MSPTSKRKSHEMADAYPGLEDATPTNSPPKKRMRITRSQKQALMDNLQLEITERARKLRAQYALQAQDLRARIERRVNRIPVILRKANMGELLEKHNASLRAQLENSSPRKYRSPAKGSRNFTAISASGRKKAATVSPSPRRVRKQQHSPAGIYSDKENAPASGEQLDVLKNPKRRTKAGTTGGTSRIVSQEVRGADYRILSPKSSNSRTYPQSPLLRSPEKAQPSSYLSRPMSPLKPSSPLKSTTGNYAASRTGSSRGAVPPRPPSSQTKRPASRAATAGPRSIRSPLSRPGTRQTDRRGSVSSSASSGTTVAKTSSSRRITTASTASAATKMSTARSQASAAAKKTTVSGSRKATVPAGSETATGGRRVLRKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AWQ9</accession>
    <accession>C8VCT9</accession>
    <name>Q5AWQ9_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ANIA_07271</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF78728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_680540.1">
        <property type="nucleotide sequence ID" value="XM_675448.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AWQ9"/>
    <dbReference type="GeneID" id="2869955"/>
    <dbReference type="KEGG" id="ani:ANIA_07271"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN7271"/>
    <dbReference type="HOGENOM" id="CLU_685165_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AWQ9"/>
    <dbReference type="OMA" id="NTCEAIF"/>
    <dbReference type="OrthoDB" id="4500289at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF78728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="402" mass="43823" checksum="661F4077762A1F90" modified="2005-04-26" version="1">MYNAVHPQEAPQQMPQIRAMGSVASPILLPISATGPVPLSLTLASDNLSPNASSAFSMIPISMDVEEGAPQPEFRDIQPWDLKHPVAVYANRDGKQLPVFYDAATQEYYLFTIEGAVLLHKTPTITIKKRQARQVLGRISYSQIRRITETELAESIMKGIDLPLSSSPLVDSVSLLRNAMHDSIIVTRNSRPTTFFRFWEDKDVRDSGTLGSDSLLMYLRPSMDGLVGHRCDALWHCGNNVIYCSKCTSYRLPSTCPTSGDADKADNTLTFGPPIPVGRVTVGVHITRKIFDGCLRPDKKGLNIPHAYQTLSKIFHKPTIDSIPIPQTYMVSNLLKDSLFVVADMFPKTAAESWADYFDVGGEHAQQGMSGMTNAAVGVTAGSAIIGTGAMVGLRIAEVVGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AX18</accession>
    <accession>C8VD62</accession>
    <name>Q5AX18_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Flavin reductase like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_07162</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF78951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_664766.1">
        <property type="nucleotide sequence ID" value="XM_659674.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AX18"/>
    <dbReference type="GeneID" id="2870077"/>
    <dbReference type="KEGG" id="ani:ANIA_07162"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN7162"/>
    <dbReference type="eggNOG" id="ENOG502QT5Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059021_3_4_1"/>
    <dbReference type="InParanoid" id="Q5AX18"/>
    <dbReference type="OMA" id="PHNPFNA"/>
    <dbReference type="OrthoDB" id="298012at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43812">
        <property type="entry name" value="BLR2425 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43812:SF2">
        <property type="entry name" value="FLAVIN REDUCTASE LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00903">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavin reductase like" evidence="2">
        <location>
            <begin position="19"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF78951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="241" mass="26692" checksum="DA0FB8A9F2BFD635" modified="2005-04-26" version="1">MFYKPGVTDHGLPHDPFKACVIPRPIGWISTKSAGPSGTANLAPYSQFNNLTFDPPYVMFSSNQTPSNERKDTVRNVESTGQFVWNLATYPLREAVNITAEQVPYGIDEFERAGLSKEDANLVDVPMVKESPVKFECVYHSTIRLPGNPPMGTVDIIIGRVVGVHIADGVINERGLLDVSRTQPIARCGYYQYAVIRETFDMVIPGMSEDILKGLEGSVKGNTEMGLRGRRGEGERNEKER</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="136" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AXB3</accession>
    <accession>C8VB35</accession>
    <name>Q5AXB3_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ANIA_07067</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF79152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_664671.1">
        <property type="nucleotide sequence ID" value="XM_659579.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AXB3"/>
    <dbReference type="GeneID" id="2869938"/>
    <dbReference type="KEGG" id="ani:ANIA_07067"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN7067"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_1_1"/>
    <dbReference type="InParanoid" id="Q5AXB3"/>
    <dbReference type="OMA" id="ANGWYMT"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000078">
        <property type="entry name" value="MFS maltose transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF10">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="107"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="130"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="291"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="331"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="358"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="386"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="427"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="461"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="31"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBF79152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="536" mass="59461" checksum="9ADF8DA14DDEFCE7" modified="2005-04-26" version="1">MSNTIQGEEVQTVTEGRRDTSLKANWRVFAITLYMGIALFEYGFDKGAIAGFQAMPGFLQVFGYQTESGEWDIHAGPQQIITSFMILGSVIGSLLTGFVGARIGRRYGLMLGSLIVIICVVIMSETTVLGALYFSRLLIGIGNGLLLNFTVLYLQECTPPRFRGLCLSMVTCWITIGTTIGMVINHQTNGMMSREAYRIPLYVCYPAPAILILTLPLLPESPRWLLQHGKPEAALRSLQFFRQGAYDEVAVQQEFEEMKAAAARERDQEIHQNKWLLFFELFRGHNLRRTIIAVAVGTANAAVGAMFILSYGTYFFQVVLQQANVGDPFKWIIVTNCVGLAGLFTTWAIVTHVGRRRIILAGCVICTLPMLVMAAVYSAPNVSADGAGIALVVIVSIYVFGFNFGLEPYVYLVAGEMPSQNLRGYTMGLSTAVSFVFAWLSAFTTPYFINPGELNWGPKYGYIWFGSGIITTAFLWYYLPEVRGRTLEEIDEMFRNNVPTRAFAKYVCVERMEANARAVSTVKGESKPNATHVEVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="107" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AXJ4</accession>
    <accession>C8VCB6</accession>
    <name>Q5AXJ4_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Calcium/ hydrogen exchanger, putative (Eurofung)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">ANIA_06986</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF79317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_664590.1">
        <property type="nucleotide sequence ID" value="XM_659498.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AXJ4"/>
    <dbReference type="FunCoup" id="Q5AXJ4">
        <property type="interactions" value="18"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5AXJ4"/>
    <dbReference type="GeneID" id="2869965"/>
    <dbReference type="KEGG" id="ani:ANIA_06986"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN6986"/>
    <dbReference type="eggNOG" id="KOG1397">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001583_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AXJ4"/>
    <dbReference type="OMA" id="PQWDMIT"/>
    <dbReference type="OrthoDB" id="16982at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990816">
        <property type="term" value="C:vacuole-mitochondrion membrane contact site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015369">
        <property type="term" value="F:calcium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
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        <property type="entry name" value="CaH_exchang"/>
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        <property type="entry name" value="VNX1 PROTEIN"/>
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</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AXL5</accession>
    <accession>C8V3F2</accession>
    <name>Q5AXL5_EMENI</name>
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        <recommendedName>
            <fullName evidence="5">LysM domain-containing protein</fullName>
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        <name evidence="6" type="ORF">ANIA_06965</name>
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        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
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            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
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            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="LysM_dom_sf"/>
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        <property type="entry name" value="LYSM DOMAIN-CONTAINING PROTEIN"/>
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            <begin position="1"/>
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        </location>
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    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBF71846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="264" mass="28267" checksum="FAD06B6B55F9FE9F" modified="2005-04-26" version="1">MHLANIVAAGLAPAMATALSPSLSYFVVECVYSTLPDPGATCSSLASSWDLTVDALQQLNPDISCPGLDLSRSYCIIGTVTEDTYEPSTTLTTTTSTSTSIRTTTTSTTAATTTITSPSNSPTMPGIAENCDGFYQISAGDQCLTIAAKHSITMDQLKSWNSAVNNDCTNLWLDYYICVHVPSASTTEPTGPGTTDESEVPTGPTPQMPGIVYNCKSYYLIESRESCWSIYTGAGITFEQFRLWNTHVDAACSNLWLGYYPSSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="113" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AXQ8</accession>
    <accession>C8V304</accession>
    <name>Q5AXQ8_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">CCCH finger DNA binding protein, putative (AFU_orthologue AFUA_5G13930)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ANIA_06922</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF71743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_664526.1">
        <property type="nucleotide sequence ID" value="XM_659434.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AXQ8"/>
    <dbReference type="FunCoup" id="Q5AXQ8">
        <property type="interactions" value="1311"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5AXQ8"/>
    <dbReference type="GeneID" id="2870634"/>
    <dbReference type="KEGG" id="ani:ANIA_06922"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN6922"/>
    <dbReference type="eggNOG" id="KOG1763">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042870_1_0_1"/>
    <dbReference type="InParanoid" id="Q5AXQ8"/>
    <dbReference type="OMA" id="GREMFYF"/>
    <dbReference type="OrthoDB" id="278280at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032378">
        <property type="entry name" value="ZC3H15/TMA46_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12681:SF0">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12681">
        <property type="entry name" value="ZINC FINGER-CONTAINING PROTEIN P48ZNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16543">
        <property type="entry name" value="DFRP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="91"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="166"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="91"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="166"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="264"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="318"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="31"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="264"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="293"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="318"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBF71743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="340" mass="39041" checksum="3F9888A4430BC195" modified="2005-04-26" version="1">MPPKKPDQPKKKKATVDDKTFGMKNKKGGSAKKQIAQLQAQAAHSKTADEKRKAAEKERREAEKRAAEQAKKEALELFKPVQVQKVPFGVDPKTVLCQFYKQGHCEKGRKCKFSHDLNVDRKAAKKDLYTDSREAEDEKKKADTMEQWDEAKLRSVVLSKHGNPRTTTDKVCKYFIEAVENQKYGWFWVCPNGGDKCMYKHSLPPGFVLKTKEQRAAEKAMMDKSPLNTLTLEDWLESERHKLTGELTPVTPETFAKWKKERMDKKAAEEQARKAKEATGRTLFESGNWRTEESEEESDEDDDGAWNLAALRKETERIREQKEEERLAKLHGEQQPGGED</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-04-18" modified="2025-06-18" version="115" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AXT6</accession>
    <accession>C8V2X0</accession>
    <name>PPIL2_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidyl-prolyl cis-trans isomerase-like 2</fullName>
            <shortName>PPIase</shortName>
            <ecNumber evidence="3">2.3.2.27</ecNumber>
            <ecNumber evidence="1">5.2.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Cyclophilin-60</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Cyclophilin-like protein Cyp-60</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">RING-type E3 ubiquitin transferase isomerase-like 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Rotamase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">cyp8</name>
        <name type="ORF">AN6894</name>
    </gene>
    <organism>
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 3">May catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides thereby assisting the folding of proteins. May also function as a chaperone, playing a role in intracellular transport of proteins. May also have a protein ubiquitin ligase activity acting as an E3 ubiquitin protein ligase or as a ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the cyclophilin-type PPIase family. PPIL2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="3"/>
    <dbReference type="EC" id="5.2.1.8" evidence="1"/>
    <dbReference type="EMBL" id="AACD01000113">
        <property type="protein sequence ID" value="EAA58293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF71677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_664498.1">
        <property type="nucleotide sequence ID" value="XM_659406.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AXT6"/>
    <dbReference type="SMR" id="Q5AXT6"/>
    <dbReference type="STRING" id="227321.Q5AXT6"/>
    <dbReference type="EnsemblFungi" id="CBF71677">
        <property type="protein sequence ID" value="CBF71677"/>
        <property type="gene ID" value="ANIA_06894"/>
    </dbReference>
    <dbReference type="KEGG" id="ani:ANIA_06894"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN6894"/>
    <dbReference type="eggNOG" id="KOG0883">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012062_7_0_1"/>
    <dbReference type="InParanoid" id="Q5AXT6"/>
    <dbReference type="OMA" id="NFIKHCA"/>
    <dbReference type="OrthoDB" id="407558at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01923">
        <property type="entry name" value="cyclophilin_RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16663">
        <property type="entry name" value="RING-Ubox_PPIL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000079">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000014">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase cyp65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026951">
        <property type="entry name" value="PPIL2_U-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625:SF1">
        <property type="entry name" value="RING-TYPE E3 UBIQUITIN-PROTEIN LIGASE PPIL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51698">
        <property type="entry name" value="U_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0697">Rotamase</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="chain" id="PRO_0000232985" description="Peptidyl-prolyl cis-trans isomerase-like 2">
        <location>
            <begin position="1"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="domain" description="U-box">
        <location>
            <begin position="42"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="4">
        <location>
            <begin position="309"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="227"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="439"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="479"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="553"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="439"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="490"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="Q08752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="Q09928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="3">
        <source>
            <dbReference type="UniProtKB" id="Q13356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="6"/>
    <sequence length="580" mass="64101" checksum="F2D0D7B8FBA7FA21" modified="2005-04-26" version="1">MGKGTDKLYITHSEWASEDAYSASAGAGVGKARRGVGEASFKRLPFRFCSLSLQPFEHPVCTQSGTIFDLTSILPWIKKHGTNPVDGTPLKGSDLIKLTIAKNDAGEYIDPVTYKVLTDNTHVVALRNTGNVFAWDTIERLNIKGKMWRDLVSDEEFTRKDIITLQDPQNIESRDLSRFNHIKEGESGLSDEQLREREDPSRNVNVNALGSSAKILKAREAVAKARQERAQKAGNAASTPVAKTDAPVKSAQKTASYQSGKPVPYNAARYTTGLAAASFTSTGMTPHTSAELALLSDEDYMLKRGRVKQKGYARISTTSGDINLELHTEYAPKAVWNFIKLAKKGYYKDVTFHRNIKGFMIQGGDPTGTGRGGESIWGKYFNDEFEGPLKHDSRGTLSMANKGKNTNSSQFFIAYRALPHLNLKHTIFGHVIDDPTPSSPTLNKLETHPVNPTTNRPTPDIRIVDVTIFVDPFEEFLKQKKQSEQSAENEANRTAENDEEGSRRAEDDQITWTGKRVRGPGASKEESSTTVGKYLKAALSERAAHDEDEIVEFVDEEPTSEPAKKKFKGIGGFGDFSSWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="107" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AY87</accession>
    <accession>C8V1Y3</accession>
    <name>Q5AY87_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hydrolase, CocE/NonD family, putative (AFU_orthologue AFUA_7G00600)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_06743</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF71371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_664347.1">
        <property type="nucleotide sequence ID" value="XM_659255.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AY87"/>
    <dbReference type="ESTHER" id="emeni-q5ay87">
        <property type="family name" value="Cocaine_esterase"/>
    </dbReference>
    <dbReference type="GeneID" id="2870264"/>
    <dbReference type="KEGG" id="ani:ANIA_06743"/>
    <dbReference type="eggNOG" id="ENOG502QZDY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015590_2_0_1"/>
    <dbReference type="InParanoid" id="Q5AY87"/>
    <dbReference type="OMA" id="FWTKHGY"/>
    <dbReference type="OrthoDB" id="416441at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02231">
        <property type="entry name" value="cupin_BLL6423-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3020.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005674">
        <property type="entry name" value="CocE/Ser_esterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000383">
        <property type="entry name" value="Xaa-Pro-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013736">
        <property type="entry name" value="Xaa-Pro_dipept_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050585">
        <property type="entry name" value="Xaa-Pro_dipeptidyl-ppase/CocE"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00976">
        <property type="entry name" value="CocE_NonD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43056:SF10">
        <property type="entry name" value="COCE_NOND FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G00600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43056">
        <property type="entry name" value="PEPTIDASE S9 PROLYL OLIGOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02129">
        <property type="entry name" value="Peptidase_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08530">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00939">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xaa-Pro dipeptidyl-peptidase C-terminal" evidence="2">
        <location>
            <begin position="319"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF71371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="793" mass="88240" checksum="5BCC5D276F42C984" modified="2005-04-26" version="1">MPNPIRADITTIDSTSFPYIFEQNVTITLKDNSGLVRCNVYRPKSPEKVPVLVTYGPYGKDIPYADFHPKSFSEVNPEHRSQHSAWETPDPAFWTKKGYAVVRADERGTGQSRGKLDTMSRETSEAFFDVVEWAAEQEWSSGKVGLLGISYYAGSQWRVAARQPKGLACIIPWEGMSDYYRDRCRHGGILSNSFISFWWNRQVLSNQYGRPGRAARNWGVDTIEGDLVEEELEANRQDQTVDNRINRFRDDLYYASKEYTMSDIQVPLLSVANWGGILLHLRGNVEGYTQAGSQLKYLRFITGRHDLPFYYKEEVDIQLSFLDAFLKGDDRAGWSTGTAPKVDLVLRKGDVGFNNAEAEKTYARRVENEWPIARTQYTRFYLTPNRELLTTPPEQKGYSKLSYAALGNIENPSFIQFTTPPFEHETEITGHIVAHLNVSMSPNPGAPTPTDIDLFLTLRYISPEGKEVYYTGTAGDPVPLCKGWLRVSLRKVNDKHARHREYLPHRDYFSTDVQPVIPGEVYPVDVEIWPTNVVVEKGGQIVLEVASGDTQGSGIFLHNEPTDSGVSLHILDVFHAPDVDAVVPNTARPWLAQPASPKMSASNESSAPKNLRPLSRYITTHNAAGKAIFSESIAPTMPVTPIPDGADFSLAYTSPTIPASFANETDIAAYASYLEPGNSPGLVISTGSVCRIVDMPPNALSSMHRTVSLDYGVVLEGEVQLELDSGETRLLKRGDVAVQRGTNHAWRNVTPPGEDGQAQWARMLYVLLPAKTVEIDGKALGEELGHIGVRSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="104" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AYE7</accession>
    <accession>C8V1L8</accession>
    <name>Q5AYE7_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">L-ornithine N(5)-monooxygenase</fullName>
            <ecNumber evidence="5">1.14.13.196</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">L-ornithine N(5)-oxygenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">ANIA_06683</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-ornithine + NADH + O2 = N(5)-hydroxy-L-ornithine + NAD(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:41512"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78275"/>
            <dbReference type="EC" id="1.14.13.196"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-ornithine + NADPH + O2 = N(5)-hydroxy-L-ornithine + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:41508"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78275"/>
            <dbReference type="EC" id="1.14.13.196"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Siderophore biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the lysine N(6)-hydroxylase/L-ornithine N(5)-oxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.196" evidence="5"/>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF71241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_664287.1">
        <property type="nucleotide sequence ID" value="XM_659195.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AYE7"/>
    <dbReference type="GeneID" id="2870471"/>
    <dbReference type="KEGG" id="ani:ANIA_06683"/>
    <dbReference type="eggNOG" id="KOG1399">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006937_7_0_1"/>
    <dbReference type="InParanoid" id="Q5AYE7"/>
    <dbReference type="OMA" id="DVASHFY"/>
    <dbReference type="OrthoDB" id="74360at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051209">
        <property type="entry name" value="FAD-bind_Monooxygenase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025700">
        <property type="entry name" value="Lys/Orn_oxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877:SF5">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13434">
        <property type="entry name" value="Lys_Orn_oxgnase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0274">FAD</keyword>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0521">NADP</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CBF71241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="503" mass="56694" checksum="23C6BE0FDE229FA5" modified="2005-04-26" version="1">MIVDTDVLIIGAGLSGVGFAIQLQKKYPRITFEIYEKAEGFGGTWWANTYPGCACDVPSHLYSYSFALNPDWSEQFASQAEIAAYCRAVAEMHDIPRHVTLRSTVQSATFDEYLGTWAVKILDQQTGRIYERHSRVLITAVGMLSEPKDCDIPGAEEYNGRLFHSACWDHEFEWAGKEVVVVGNGCSATQFVPILTNTPGSAKQVTQFIRQPHWLEPRPNPEYPSAIKWIFRHVPLVMRCFRYAIFLYLESYFSTFKRVSGKRTREARMKSQAAYLKKMAPKKYHEILTPRIELGCKRRVMDTDYLACLHRENMELIHDDPIERITVDGVRTKSGRKIYADAIILATGFKTAQPLFPLGDNIRGEGGVTLSEHWESTASHAPQAYYGTCVSRFPNMFILVGPNTATGHTSVLFTVECQIDFTLKVLDPILNSLYPESSSSSSSVLQEMICFLRKPFSSGPRAGKKLALPPDIVSVTSQAEEKESQWIDEAILKELWKVFAAEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AYU2</accession>
    <accession>C8V0M0</accession>
    <name>Q5AYU2_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">LRR-containing protein second PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_06538</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF70941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_664142.1">
        <property type="nucleotide sequence ID" value="XM_659050.2"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5AYU2"/>
    <dbReference type="GeneID" id="2870223"/>
    <dbReference type="KEGG" id="ani:ANIA_06538"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN6538"/>
    <dbReference type="eggNOG" id="KOG4308">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003789_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AYU2"/>
    <dbReference type="OMA" id="CEDAPCF"/>
    <dbReference type="OrthoDB" id="120976at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052394">
        <property type="entry name" value="LRR-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057334">
        <property type="entry name" value="PH_2nd_LRR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24114">
        <property type="entry name" value="LEUCINE RICH REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24114:SF41">
        <property type="entry name" value="PH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25353">
        <property type="entry name" value="PH_2nd_LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LRR-containing protein second PH" evidence="2">
        <location>
            <begin position="282"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1127"/>
            <end position="1146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1170"/>
            <end position="1285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1206"/>
            <end position="1243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF70941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="1285" mass="142140" checksum="5BDA500FB9C7BA09" modified="2005-04-26" version="1">MAQSLGKRERRKSLGSFGPLSTTSNPGPIPLDRSTIHETNVLRKKQRRNSGFFGGRNPSPVRASTGYRDPGTVAPVRVATSPALDGPRARRKSLQKRRNSVFGSLRSLHSLDDDDPNRRSLDSEEGHGVGSIILHHGEIQITGGVWRKKSQYLVLTDTHIVRFKSLNKALETFPSIPPSMARSGSNRQSIASISSLQDPQLSAVGDASVGIPLNSIVAVYMLDDGKPSSSIEVAYMDERTQKTTFIQMQTPDIQELNLWMVGIRSAAEMSRSNTPMPYDPRALDCVIRILEHERDYDPEIFRMFRVIQMASSKSPTRASADELTKLSPTGCYLALGMHKLHLVSLQKVSSRGSTASLTDLDAATSFGLMNLTSLSMEWGDDSLHLTFRVPLQKSCSIFVASVHSLEIAYWIRQQTEFLRPLWLKQPYDFIVPRDLNNENNFPPVCLDEDYGCFDRTLVAHCASYGIDTSNIRYTIDTQCDDAPCFRLLRPASPQRSKYTALELIALMRTLRYNESFRSISFSGVSLDAIQDVRDLNGIDKDALLTRANAQIHIPGQENLSVLSQEIRALSLKSKWLRRLDFSYTLSRTPKSDNDSHDPGCGIPEAIFPICRRELTNVDWIVLNGIKLGDSDLDYLVDAASQRSSHFRALEVGNCGLSVHDIDLLLSTTVAQVSTLEAINISGIQGRIKPDMLQQYLGYFGQVKKLDLSRIARTSGPEPLIPAQVLFNWRLEELSMNQTPANRETVDAIATYLASDRSECLRVIRLDQCGLSGQDVAIFLHSLAALQHSRDLHLHVNDNRLDLGCSYLCDAIAQDKTPTHLSMRMIDFKKEQQFQDLVEALRKNRTLKYLDISKASLPYDAGPETSKSLQLMFEENDTLEDLDISGDNAHLDVARFGIGLNLALTGLKKNSSLKVLRIEHQKLGLQGANTLASVLESNTSLLEVYCENNDINLQSFTVLVNGLQNNRSLLSLSCMDCDRARSLDKVRREIANVKRDLTHSQPSTSSLRRSLHAAINAKHMSVNSKLAKHSRSYGHIRATASSLSAVESSKPPMDDQVEAIMQSLSAKWDAEVSRLRRYLFRNFNLANGLSKDGTDFVGDDAESDGRPATAASLGTMLEQLKLDVALSTNDTQEQRSQMPPQSAPQISVADSSPHLEIFQSLDVENGLDDELQKSPYLSSNPEIASQPFPDYGASNSRSALPVPTMPSAVSKTSSVRSTRSSSTVSTSTGTGASARSTYGAASSTLRGLLSSRERKKMEAMKGTVCVGDRPPTLDWSPPRFDLGELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AZ01</accession>
    <accession>C8V045</accession>
    <name>Q5AZ01_EMENI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_06479</name>
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    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF69373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_664083.1">
        <property type="nucleotide sequence ID" value="XM_658991.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AZ01"/>
    <dbReference type="GeneID" id="2871377"/>
    <dbReference type="KEGG" id="ani:ANIA_06479"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN6479"/>
    <dbReference type="HOGENOM" id="CLU_439420_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AZ01"/>
    <dbReference type="OrthoDB" id="4508904at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="504"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="371"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="520"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF69373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="622" mass="70226" checksum="B3FC6E24B3CE901F" modified="2005-04-26" version="1">MSPQCPVPRYLNQNQDSKIELVVPGDYPGNSPKESLISVEATARLPLPENDPSGSVDELPGLLLGVKSIDTTTKIEPPEQLRLLHVSNNDYGMEFSAFLGRALEAYGLTEPHTQKTIFKFFDRFLELSEQSAFRGGRFSPVPASTKVRLPARNGSKEEEVRVTFIAIPYFLLHDAQRPPQRAIMSRNKVHWVQPLVQSGYHLDSSMMREDQQAIRRLYRHIKQVIHVPQLWVLSIGHNFVATCAPTPLFDGQRSPSASPCIALRAIGEQTAFPPTVRITTPWGFVFCLELRKCGVWSGFLYQVQVMLSSVAPENTSIDTRNWVYSLEVDGSTIDARRWRSLWEAHGDNNPLLAIIASPPPEHIPRRKEPTEPTTSPSSLSAETPEPRYPSGISDTLKKLDERMREHRERRSRTIATTQSKYAGDDDADGLRNPFSRRFPSSVKHRVRRYRSAGFRNYDNDHPYQYIDPYYFPPQFVLDAIRNQFKAEKEDGESHGLAQGASGAVGVAQADGPGPGAQSATKRDKKQEQEKPLPVFKWSIGKKASEEASSNSDEAESTRRMESLLAYIHRHMLFHTNNKKSSSYFPQTTKASTKVLNRTYNAIPLKTRSIVDSQLLHLRDTYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AZP6</accession>
    <accession>C8V1Q9</accession>
    <name>Q5AZP6_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Siderophore biosynthesis acetylase AceI, putative (AFU_orthologue AFUA_3G03400)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ANIA_06234</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the lysine N-acyltransferase MbtK family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF69890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_663838.1">
        <property type="nucleotide sequence ID" value="XM_658746.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AZP6"/>
    <dbReference type="STRING" id="227321.Q5AZP6"/>
    <dbReference type="GeneID" id="2871052"/>
    <dbReference type="KEGG" id="ani:ANIA_06234"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN6234"/>
    <dbReference type="eggNOG" id="ENOG502SMIQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039848_1_0_1"/>
    <dbReference type="InParanoid" id="Q5AZP6"/>
    <dbReference type="OMA" id="GQIWNVI"/>
    <dbReference type="OrthoDB" id="4250781at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016410">
        <property type="term" value="F:N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019290">
        <property type="term" value="P:siderophore biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000080">
        <property type="entry name" value="Siderophore biosynthesis acetylase AceI, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019432">
        <property type="entry name" value="Acyltransferase_MbtK/IucB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31438:SF6">
        <property type="entry name" value="BIOSYNTHESIS ACETYLASE ACEI, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G03400)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31438">
        <property type="entry name" value="LYSINE N-ACYLTRANSFERASE C17G9.06C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13523">
        <property type="entry name" value="Acetyltransf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01006">
        <property type="entry name" value="AlcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyltransferase MbtK/IucB-like conserved" evidence="3">
        <location>
            <begin position="251"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="73"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBF69890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="443" mass="51225" checksum="3EB7C210F5B1548E" modified="2005-04-26" version="1">MAAKQQYPWVKLPHPYLTTYRIHIVSDSSPRVLQLRLHDSQVPGEPLAEPLHNDALTYTDIAFDESAKDIPDNDNSPWARSQRAPGTTFQWTGTEPPSFAQIWNVIHAIFLTHPQREVLRLDLKGAGNEIVREECIRTGLAVPYPSPRVPFGNESEPSGIDTLILLRSSFWQGAGSPLGPRPIWMVDQGTHGLARKSLSQYPVMPKNYEFSMKFPRERIYARHPVRPAKPTPGSLVYSRYIPHLDKHFSLMVVDWQNEEHLKRFNRWQNDPRVAKGWNETGTLDEHREYLRRLHEDKHVLCLFGRFDDFPFAYYEIYWAKEDHYGAHYDAGDYDRGRHSLVGEESIRGAERVNAWWSSCIHYCFLDEPRTQCVVGEPKATGGTVLSYENAQGLTIQSYVDLGHKRSVHVFCSREKWFQLCPLFWDGRERPLESSDRAAWNAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B002</accession>
    <accession>C8V2C8</accession>
    <name>Q5B002_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_06128</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF70126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_663732.1">
        <property type="nucleotide sequence ID" value="XM_658640.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B002"/>
    <dbReference type="GeneID" id="2871057"/>
    <dbReference type="KEGG" id="ani:ANIA_06128"/>
    <dbReference type="eggNOG" id="ENOG502SBPR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036324_0_0_1"/>
    <dbReference type="InParanoid" id="Q5B002"/>
    <dbReference type="OMA" id="QTDTMIE"/>
    <dbReference type="OrthoDB" id="2016523at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="CDD" id="cd22189">
        <property type="entry name" value="PGAP4-like_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029675">
        <property type="entry name" value="PGAP4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31410:SF1">
        <property type="entry name" value="POST-GPI ATTACHMENT TO PROTEINS FACTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31410">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="308"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="337"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF70126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="484" mass="55341" checksum="5C68F279AD6F5317" modified="2005-04-26" version="1">MYPSTHSPLLVESLLPVEMPLPLPLSAVAKRAPAQLTHILKLRASRIFLSSLLLWLLLYAYCRTRFWRDPHSAFFQEAHVYDLDYSLYREREGTHFLARHNAPTTRPGEEFHYHYTKNNSEGGSETPAVCVAIVTVRREQDTYFDASVGSLLEGLTEHERKPLHLSVLFADIDPAVHPSWGQKWVERLVDQVGGYNVSAEQLEDLRKWEAERNFYRKGVFDYIYALRTCQGVNAPYTLIFEDDIILATGWFARTLKSLAEISRREAGANQGHSHAAKNQKPWLYLRLFYTETALGWSSADFAYEHMPLIFLTLTALSFTALYFLQRSRRFQPLHLDTPSILVISLLCIPAFTALAYMVGKYNLMPLRGVVQMNKFGCCTQGLLFPAQQVDRLIGFLEDRGHGQTDSLIEEYADLNGLNRYAVALPLLQHVGLKSSRDNTDVNTQSTWAFWFETNKPEALRREHAELLGDADVQQMLELPCPRLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="103" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B066</accession>
    <accession>C8V2T8</accession>
    <name>Q5B066_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GDSL Lipase/Acylhydrolase family protein (AFU_orthologue AFUA_2G08920)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_06064</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF70259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_663668.1">
        <property type="nucleotide sequence ID" value="XM_658576.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B066"/>
    <dbReference type="FunCoup" id="Q5B066">
        <property type="interactions" value="234"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5B066"/>
    <dbReference type="GeneID" id="2871155"/>
    <dbReference type="KEGG" id="ani:ANIA_06064"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN6064"/>
    <dbReference type="eggNOG" id="KOG3035">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051989_0_0_1"/>
    <dbReference type="InParanoid" id="Q5B066"/>
    <dbReference type="OMA" id="VIWPKVI"/>
    <dbReference type="OrthoDB" id="671439at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="CDD" id="cd01838">
        <property type="entry name" value="Isoamyl_acetate_hydrolase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1110:FF:000019">
        <property type="entry name" value="GDSL Lipase/Acylhydrolase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045136">
        <property type="entry name" value="Iah1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14209">
        <property type="entry name" value="ISOAMYL ACETATE-HYDROLYZING ESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14209:SF19">
        <property type="entry name" value="ISOAMYL ACETATE-HYDROLYZING ESTERASE 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGNH hydrolase-type esterase" evidence="1">
        <location>
            <begin position="17"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF70259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="257" mass="28650" checksum="5A1537398CAD1E66" modified="2005-04-26" version="1">MSAVEDSLYKPYDQFVLFGDSITQMSSNQDQGFGFQPALQDAYSRALDVINRGFGGYTTAHAVKVFPKFFPTPETATVRFLTIWFGANDASLLESDNKQHVPLDVYKKNLVSLVQHPATVAQQPRIIIITPTPVNEYQLQSFDEDKGNVHPTRKNSRAREYAQAAREVAESLNIPVVDLWTAFMTAVGWKEGDPLIGSREGPNDEKFASLFTDGLHLTADGYRIVYNEVVGAIEANWPDQAPGKLPYVHPAWMEAPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="110" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B0A8</accession>
    <accession>C8V323</accession>
    <name>Q5B0A8_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Aldehyde dehydrogenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ANIA_06022</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF70342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_663626.1">
        <property type="nucleotide sequence ID" value="XM_658534.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B0A8"/>
    <dbReference type="STRING" id="227321.Q5B0A8"/>
    <dbReference type="GeneID" id="2871097"/>
    <dbReference type="KEGG" id="ani:ANIA_06022"/>
    <dbReference type="eggNOG" id="KOG2455">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005391_4_1_1"/>
    <dbReference type="InParanoid" id="Q5B0A8"/>
    <dbReference type="OMA" id="NVYYPYM"/>
    <dbReference type="OrthoDB" id="5322683at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003842">
        <property type="term" value="F:L-glutamate gamma-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010133">
        <property type="term" value="P:L-proline catabolic process to L-glutamate"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050485">
        <property type="entry name" value="Proline_metab_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42862">
        <property type="entry name" value="DELTA-1-PYRROLINE-5-CARBOXYLATE DEHYDROGENASE 1, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42862:SF1">
        <property type="entry name" value="DELTA-1-PYRROLINE-5-CARBOXYLATE DEHYDROGENASE 2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="4">
        <location>
            <begin position="191"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="4">
        <location>
            <begin position="419"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="120"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="354"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="373"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBF70342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="610" mass="67780" checksum="EE80CC8D14DCF05B" modified="2005-04-26" version="1">MGEGVMCAGAKDLRDRLHTPFNYRDRGRNQQRCNCGSREVCPERAPVRAELVISRCATRMIASDALWGNMLGGAPDAAEDKAPFSFQIELPTSILKHIYAISNRLLTSRLSSADLRLPRPQIRTKATAPSRLPDARNEPNPTYVKGSSERLKIESALSKLRSQLPVQSSIYYNGKVQAAWRSWDQPLPAEHAAIESALKAKKDWENTPFIDRAAIFLKAAELVTGKYRYELIAATMLGQGKNIWQAEIDAAAELADFFRLNCNFAAELLERQPTRGTVGMWSRMEYRPLEGFVYAVSPFNLTALGGSLLSGPALMGNVVLWKPSPPNVYTSTLIYKILLEAGLPADVVQFVPGARKKSPTSRYKREELPPHPPHGRHSQRRQPHHPRCIRVPGTKVLGDLARIHPSVPRGRIHLAPQGRVQEITIGSPDKELEAFMGPVIHRRSFDQIKRIIDESNDDPSLNSITGGTYDDSVGFYVHPTVYQANAPTHRLFDEIFGPIPALYVYLDNEWSEILAKVDQAGGGFALTGPVFATDRRVIWEAEDALGYSAGNFYINCKTTAALIGQQLFGGARASGTNDKAGSSDILRRFPSLRMIKEFFLLEGFKYPSNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B0E2</accession>
    <accession>C8V3A6</accession>
    <name>Q5B0E2_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_05988</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF70410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_663592.1">
        <property type="nucleotide sequence ID" value="XM_658500.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B0E2"/>
    <dbReference type="GeneID" id="2870913"/>
    <dbReference type="KEGG" id="ani:ANIA_05988"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN5988"/>
    <dbReference type="eggNOG" id="ENOG502RJH1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002672_0_0_1"/>
    <dbReference type="InParanoid" id="Q5B0E2"/>
    <dbReference type="OMA" id="MGLFNKP"/>
    <dbReference type="OrthoDB" id="5335210at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="356"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="447"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="947"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1016"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="356"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="447"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="472"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="528"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="548"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="571"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="631"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="644"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="661"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="698"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="828"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1057"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1085"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1117"/>
            <end position="1126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF70410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="1142" mass="124577" checksum="2DB475E0B73E9143" modified="2005-04-26" version="1">MNRFRKSKKEKEVKREKAKEDVVVTETSVPPTTFGAILKKNKKEPESKPDLDIDLSSALPSTDDFRTSLLMPKLSARFSMLREQDDPESLIGKASDDSVLFPRRASRLNLFGHNPSLLTDIDEVSSSGRPSFNHERGSYASGSDGYNGDDDSQHQGSIMSRGRRTEGNNLFGGRQKVYKIPSSGSGRSGRALYEHDVNNSLFRRKPSVKKGNEEEHAPNSPQESEDALSRVSSVNRTTFSSTTSGPMSNTRISTAATSVDEHPLSTSPAQTHNSSSESIQPKPTGPGMATERASVRTRRLYGQALEQSAHTQQASALHRLESLSRQRAGTPEIPSLNRNYSRSAVNLRNGLLKLTTAESSPAASRPTSPPSSATSPSRPQIESELKPPGQPPLSPPVSENEEATLMSALQPEDRGKATAMGMFNKPRTAYDDSQFSHRQLQLFQGRNTPPLRQQSPAPAPSQDELTRQRGFSNASHRSRSGSAGSSNYSEAHRPGSRSTGKSVYASPARPGQIGTFFDNSSPSETEDEGYRPVSRDDYSIHSNHPAFRSRTPSRPTTPTAEENNNTLPEVRFSDLGDLKPIAEHRESIAEQGSNTPASPEKPDSPTIPAGLGLSGLVRTHLRQDSDKSSIMPPPSPRFPPPTEPETAPEPSTEQPQFGQPSHPPTAAPPSVPVVPDPIPDWRDELGISRHQRQASTETQREREEFANELAERRRRVQEKLRDFADESRAASPVSGRQTPDFGQPKPGNAFALLKSKTGKHHLFGRGESRGPRGLPFGGNASTPALVSDDPWGEEDRMAFPHIGRHNNSSSPHVGERSMRSRIASFSRRSQEESRESSRSRGASPHSSFRSRRERSSSNASSRSKSRSRRDRDNLTTLEEDEISSDNGFTYGRRRVTSVTSSTRPSLENYERPMFDNRAPSAASGAYFQESRSATPVDRPFAAPIANSPIIGAPRPSPAAPPFSANATPPLNDANGDSPAASTTTLPQPLPQRAAGHTGLQKRIIDKSKISEPTFISCTSNVPTVGLPPGASLSNGMETPPIPPMNPRRRRQTTTQTILNAFKSQSDYEPSQAQERSTFDDEGQKRSRSRSRPRNRLRKVSSEQGELNATADAMARQSTAPGASASPSPTPYQPRIPMDGGMF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-08-16" modified="2026-01-28" version="113" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B0L1</accession>
    <accession>C8V3K5</accession>
    <name>ATG15_EMENI</name>
    <protein>
        <recommendedName>
            <fullName>Putative lipase atg15</fullName>
            <ecNumber>3.1.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Autophagy-related protein 15</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">atg15</name>
        <name type="ORF">AN5919</name>
    </gene>
    <organism>
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Lipase which is essential for lysis of subvacuolar cytoplasm to vacuole targeted bodies and intravacuolar autophagic bodies. Involved in the lysis of intravacuolar multivesicular body (MVB) vesicles. The intravacuolar membrane disintegration by atg15 is critical to life span extension.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12044"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17855"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="EC" id="3.1.1.3"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Binds to both phosphatidylinositol (PI) and phosphatidylinositol 3,5-bisphosphate (PIP2).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome</location>
            <location evidence="2">Multivesicular body membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Prevacuolar compartment membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <text evidence="2">From ER, targeted to vacuolar lumen at the MVB vesicles via the Golgi and the prevacuolar compartment (PVC).</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <comment type="sequence caution" evidence="5">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="EAA57782" version="1"/>
        </conflict>
        <text>Truncated N-terminus.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.3"/>
    <dbReference type="EMBL" id="AACD01000101">
        <property type="protein sequence ID" value="EAA57782.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF70571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B0L1"/>
    <dbReference type="FunCoup" id="Q5B0L1">
        <property type="interactions" value="50"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5B0L1"/>
    <dbReference type="ESTHER" id="emeni-atg15">
        <property type="family name" value="ATG15-related-lipase"/>
    </dbReference>
    <dbReference type="GlyCosmos" id="Q5B0L1">
        <property type="glycosylation" value="6 sites, No reported glycans"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CBF70571">
        <property type="protein sequence ID" value="CBF70571"/>
        <property type="gene ID" value="ANIA_05919"/>
    </dbReference>
    <dbReference type="GeneID" id="2870991"/>
    <dbReference type="KEGG" id="ani:ANIA_05919"/>
    <dbReference type="eggNOG" id="KOG4540">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028295_0_1_1"/>
    <dbReference type="InParanoid" id="Q5B0L1"/>
    <dbReference type="OMA" id="CHDCYNW"/>
    <dbReference type="OrthoDB" id="58570at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032585">
        <property type="term" value="C:multivesicular body membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005775">
        <property type="term" value="C:vacuolar lumen"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004620">
        <property type="term" value="F:phospholipase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034496">
        <property type="term" value="P:multivesicular body membrane disassembly"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046461">
        <property type="term" value="P:neutral lipid catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006660">
        <property type="term" value="P:phosphatidylserine catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000129">
        <property type="entry name" value="Autophagy related lipase Atg15, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050805">
        <property type="entry name" value="ATG15_Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47175">
        <property type="entry name" value="LIPASE ATG15-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47175:SF2">
        <property type="entry name" value="LIPASE ATG15-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00120">
        <property type="entry name" value="LIPASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0072">Autophagy</keyword>
    <keyword id="KW-0967">Endosome</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0442">Lipid degradation</keyword>
    <keyword id="KW-0443">Lipid metabolism</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0735">Signal-anchor</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000090368" description="Putative lipase atg15">
        <location>
            <begin position="1"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Signal-anchor for type II membrane protein" evidence="3">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="3">
        <location>
            <begin position="42"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="4">
        <location>
            <position position="321"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="201"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="223"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="281"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="305"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="P25641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3"/>
    <evidence type="ECO:0000255" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <sequence length="603" mass="65804" checksum="38A12630C4010864" modified="2011-10-19" version="2">MDQPHRRTRKWHLMDLSVSTLLMSLALVLPSCVSAYQPVYFRSQEATPFIPPQVPSADPQSLSGTHEFTLRHIVQRGAYEYPELHRRLDIKPNTQLRTVSEDGIEDNEPAVFNVPFVASSEPVTIERLADRRLSVIEEHLAAARSAGSAVTLSSSQWTKDTLAGPNVTDKKTILTFAKMTANDYIEVPGTEDWQDINGKLNYSTSFGWQNDGLRGHIYADDTNSTIVISLKGTSPALFDGAGTTTNDKVNDNLYFSCCCGQGGSYLWREVCDCQKSAFNANLTCIIEAMNDENRYYRASLDLYSNVTELYPNANVWLTGHSLGGAMASLLGLTFGLPVVTFEAVPEALPAARLGLPTPPGYNPALPQARKFTGAYHFGHTADPVYMGTCNGVSSVCTWGGYAMESACHTGQMCVYDTVADKGWRVAIGTHRIKAVISDVIEVYDDLPQCAPEEECYDCELWKFFRSNGSEITTTSSTTTTSTITTSTRTTTCKTPGWWGCLDDSTTTDPPTTTTTTSSTCKTPGWFGCKDPTSTTATTTTEAPTTTTTCKDPGWFGCRDPTSPTTSTAPQTSTCETPGFFWGCYDTQTAVDHLITPAPILIDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="102" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B210</accession>
    <accession>C8VGK2</accession>
    <name>Q5B210_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ANIA_05420</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF81939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_663024.1">
        <property type="nucleotide sequence ID" value="XM_657932.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B210"/>
    <dbReference type="STRING" id="227321.Q5B210"/>
    <dbReference type="GeneID" id="2871711"/>
    <dbReference type="KEGG" id="ani:ANIA_05420"/>
    <dbReference type="eggNOG" id="ENOG502SK60">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008719_2_1_1"/>
    <dbReference type="InParanoid" id="Q5B210"/>
    <dbReference type="OrthoDB" id="4525710at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF2">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13508">
        <property type="entry name" value="Acetyltransf_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="4">
        <location>
            <begin position="694"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="71"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="86"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBF81939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="844" mass="94564" checksum="10C71060207DD83B" modified="2005-04-26" version="1">MAGCAASCSSRQPEAFPGDRQNPKCGRCQSRNIECMPVERKAVFRRGRVSRKHDLHENMFAVNQTWVNSRPRKWKGAKSAVDGAQQGASPNPGGSNREQASVSEGADAVELNLDYFPRQTCMDPSLDHLPVQECIGEGSTGVRARTEDSGLEDAILPRAAVEGHTSLTRLNVLVSAAVGNQTQHESPVTVQGVSYSISASPQAPYSSINSPVSSYQPLASVQESCLLRYFIEELSPWFDHCDPQSHFRQLVPHRAQRSRYPSLLNAIFAVSARHLSRLPQYRTLEGNINYHGQSLPGLSTSSAVEYMLKCIPGLSSFHDIGNLTEQENLMCAAIILRQYEEMEEEMEEMGTDPISFLTDSSFGGENTGEGDSPIEKQVNFLAITQTIIQAMISVSSPLQRSPLAVAAYWIAIRQEVYYALTRKSAPCLTFTAQDWESAAIANKMIMHAGEVTKWCWGDRTLSEYGTSPFLLALLYALSQRLRHHQQQLITAYSSQLTPILHRLADRTKGDIFPTIWYATDAQVTGVQHLELARMILIAENPRLLVSHSMHRRTEFIVRNIVLNLCGIAVDVSRRMPALVNAVISILLYGEYFTDLAERNALLNIIERMKDMRAWPLRRGVERLRRAWREADNYKYIVARYRALRLTALQRSPEAFTSTYAREAQFDDKTWTIRVLNPLATVFIVPFPETASEDIGTRPNDDEDMLMKRPWLGQLTLMGPVFFPINDEKAARVPWDLFKNIDFEQAARDAASIPAGSNVVYVLVGMYVLPEGRGAGNGQRLLEAAIRVVDEERKAKKVNATVILLVARENKKAKRLYERVGFVSWEDGVDIEGETHWALSLTLAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B2L9</accession>
    <accession>C8VF87</accession>
    <name>Q5B2L9_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">1-phosphatidylinositol-3-phosphate 5-kinase (Fab1), putative (AFU_orthologue AFUA_6G07440)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_05211</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF81091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_662815.1">
        <property type="nucleotide sequence ID" value="XM_657723.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B2L9"/>
    <dbReference type="STRING" id="227321.Q5B2L9"/>
    <dbReference type="GeneID" id="2871504"/>
    <dbReference type="KEGG" id="ani:ANIA_05211"/>
    <dbReference type="eggNOG" id="KOG0230">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_170607_0_0_1"/>
    <dbReference type="InParanoid" id="Q5B2L9"/>
    <dbReference type="OMA" id="AMSTYFR"/>
    <dbReference type="OrthoDB" id="158357at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052742">
        <property type="term" value="F:phosphatidylinositol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046488">
        <property type="term" value="P:phosphatidylinositol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.810.10:FF:000017">
        <property type="entry name" value="1-phosphatidylinositol-3-phosphate 5-kinase (Fab1), putative (AFU_orthologue AFUA_6G07440)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.810.10">
        <property type="entry name" value="2-Layer Sandwich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027483">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002498">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45748">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 3-PHOSPHATE 5-KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45748:SF7">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 3-PHOSPHATE 5-KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01504">
        <property type="entry name" value="PIP5K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51455">
        <property type="entry name" value="PIPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PIPK" evidence="2">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF81091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="108" mass="12280" checksum="36A93275851BD285" modified="2005-04-26" version="1">MIAIDESRSELVVGVIDCIRTYTWDKKLESWIKDRGFAGGGKNRPTVTSPKEYKSRFREAMARYVLQAPSCWHQFQSSRYAVMDTHVHMNQHHSLTDGDAEGAAGQSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="146" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B2Z2</accession>
    <accession>C8V7Y6</accession>
    <name>Q5B2Z2_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Calcium-transporting ATPase</fullName>
            <ecNumber evidence="17">7.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">ANIA_05088</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="23" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="23">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Catalyzes the hydrolysis of ATP coupled with the transport of calcium.</text>
    </comment>
    <comment type="function">
        <text evidence="16">This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. Transports the calcium to the vacuole and participates in the control of the cytosolic free calcium.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 17">
            <text>Ca(2+)(in) + ATP + H2O = Ca(2+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="17">Membrane</location>
            <topology evidence="17">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.10" evidence="17"/>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF76107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_662692.1">
        <property type="nucleotide sequence ID" value="XM_657600.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B2Z2"/>
    <dbReference type="FunCoup" id="Q5B2Z2">
        <property type="interactions" value="446"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5B2Z2"/>
    <dbReference type="GeneID" id="2872889"/>
    <dbReference type="KEGG" id="ani:ANIA_05088"/>
    <dbReference type="eggNOG" id="KOG0204">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002360_9_3_1"/>
    <dbReference type="InParanoid" id="Q5B2Z2"/>
    <dbReference type="OMA" id="MINVHDI"/>
    <dbReference type="OrthoDB" id="3352408at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd02081">
        <property type="entry name" value="P-type_ATPase_Ca_PMCA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000028">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000031">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000018">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006408">
        <property type="entry name" value="P-type_ATPase_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01517">
        <property type="entry name" value="ATPase-IIB_Ca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093:SF369">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093">
        <property type="entry name" value="CATION TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08282">
        <property type="entry name" value="Hydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 17" id="KW-0106">Calcium</keyword>
    <keyword evidence="4 17" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="13 17" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 17" id="KW-0813">Transport</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="392"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="433"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1021"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="21">
        <location>
            <begin position="160"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="19">
        <location>
            <begin position="258"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase C-terminal" evidence="20">
        <location>
            <begin position="903"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1084"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="26"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="1094"/>
            <end position="1105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00059328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU361146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF00690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="CBF76107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="1134" mass="123287" checksum="BF8A08A98C23D13E" modified="2005-04-26" version="1">MAQPNFPALSRPLTPPRGGSGHPGYGTQSSSKYGNSDVRASNCTLNKDNSVNGRGTKRPEPNGKSDSGMENNKFAFSPDQLDKLLNPKNFGAFGTFGGLRGLEKGLRTNVQSGLSLDETVLDGTVSFNEAVSRTFVPATKSASPAPLTPSRDTIADASQDRFVDRQRVFGTNKLPEKKLKSIWELVWIAYNDKVLILLSFAALVSLVVGIPQSVRGTGVEWVEGAAIIAAIVVVVTVGAANDWQKERQFAKLNKKKEDRYVKVIRSGQISEVSTYDIIAGDVMYLEPGDMIPADGILIEGHGVKCDESSVTGESDLLRKTPGDKVYEAVAQKKELKKMDPFIMSGSSVEEGTGTFLVTATGVHTTYGRTVMSLQDEGEITPLQVKLNALADYIAKVGLTSGLILFVVLFIKFLVRLKEIEGGAEAKGQAFLRILIVAVTIVVVAVPEGLPLAVTLALAFATTRMIKDNNLVRLLRACETMGNATTICSDKTGTLTQNKMIVVAATLDTASQFGGQPSLNNAASAPGSRAHSALEFVSTLSPSTKNHLLQSIALNSTAFESDRDGVTTFIGSKTETALLSFAREQLGLGPVAEERANAEIVQMFPFDSSRKCMAVVTCMDNGKYRMMVKGAAEILLRQSAQIVQDATNGLAAVPLSEEAKITLDTIITDYASRSLRCIALVHRDFEKWPPHGIPTDENEMAVFEPIFKDMTMLGIFGIQDPVREGVPDAVRQCQHAGVFVRMVTGDNIITAKAIAQQCGIYTPGGVAIEGPEFRELSHDQMNKLIPRLQVIARSSPDDKKILVSQLKELGETVAVTGDGTNDAQALKTADVGFAMGVAGTEVAKEASDIIIMDDNFTSIVKAIAWGRTVNDAVKKFLQFQLTVNITAVILTFVSAVASNDEDPVLSAVQLLWVNLIMDTFAALALATDPPSPHVLERKPEPKSAPLITLTMWKMIISQAIYQLAVTLVLNFAGQHIFPKWDSRCIQTVVFNTFVFMQIFNQYNCRRVDNRLNVIEGILNNRWFIAIQVIIIGGQIMIIFLGGQVFSVQRLDQPSQWAATYFIYLAPLEGPRARYLRGKPPLRVGFGSKRNPRPANVHEEGPRRTTEAYHTQAPPNFPPVPRQLTIPAFFYAPNSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="99" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B373</accession>
    <accession>C8V8L7</accession>
    <name>Q5B373_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Class II aldolase/adducin domain protein (AFU_orthologue AFUA_3G09800)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_05007</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF76291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_662611.1">
        <property type="nucleotide sequence ID" value="XM_657519.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B373"/>
    <dbReference type="STRING" id="227321.Q5B373"/>
    <dbReference type="GeneID" id="2872807"/>
    <dbReference type="KEGG" id="ani:ANIA_05007"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN5007"/>
    <dbReference type="eggNOG" id="KOG3699">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006033_1_1_1"/>
    <dbReference type="InParanoid" id="Q5B373"/>
    <dbReference type="OMA" id="REAHDWT"/>
    <dbReference type="OrthoDB" id="3238794at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.225.10:FF:000009">
        <property type="entry name" value="Class II aldolase/adducin N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="entry name" value="Class II aldolase/adducin N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051017">
        <property type="entry name" value="Aldolase-II_Adducin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004855">
        <property type="entry name" value="PRK06208.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672">
        <property type="entry name" value="ADDUCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672:SF40">
        <property type="entry name" value="CLASS II ALDOLASE_ADDUCIN DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_3G09800)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="AraD/HMP-PK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Class II aldolase/adducin N-terminal" evidence="2">
        <location>
            <begin position="75"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF76291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="312" mass="33802" checksum="5B9CB5F30F38212C" modified="2005-04-26" version="1">MSTTTATLTNPSPAQVAVAPNPELSNENSTIKNIPPAATDKVFQATARGNRAGTLKPRGIPTFSDPYAERQWIKEHMAAAFRVFGKQGFNEGISGHISVRDPVLKDHFWINPFGKHFSAMKASDLVLVDAEGYVTEGGAQQAINEAGFMIHSEIHKARPDVMAAAHTHGIYGKTWSIFGKPIEMLTQDACNFYGKLAVYEDHGGVALAQDEGRAIAKALGKENIACILQNHGLLTVGSTVDEAAWLFVSLDSACHAQLMAEAAAANGIPKRIIPDEVAQYTADAAQNAHYFYHEFQPEFDLVVEESNGRVLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="129" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B3B7</accession>
    <accession>C8V909</accession>
    <name>Q5B3B7_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cell division control protein (Cdc15), putative (AFU_orthologue AFUA_3G10250)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ANIA_04963</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF76386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_662567.1">
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</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B4C5</accession>
    <accession>C8V7T4</accession>
    <name>Q5B4C5_EMENI</name>
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        <recommendedName>
            <fullName evidence="1">Class II aldolase/adducin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_04605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CBF77164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_657117.1"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
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        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="entry name" value="Class II aldolase/adducin N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051017">
        <property type="entry name" value="Aldolase-II_Adducin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672">
        <property type="entry name" value="ADDUCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672:SF25">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 14 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="AraD/HMP-PK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Class II aldolase/adducin N-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF77164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="205" mass="22222" checksum="A122796E1EB29614" modified="2005-04-26" version="1">MSSLGLHFGIIKPSDIILVDETGIAVGGNRTRPANAAGFLIHSALHKSRPDVNAASHFHSTYGKAWSTFVQPLEMLNQDVAIFYVKAQSVYKEFGGVVLEEDESAALASALGKEGIGMILKNHGLLTVGSTVDEAAYLFLLMWKSCQIQLAADAAAAAGREKVYICDEFARFTFENTSEAESLHAEFQVYLQFESGDSHDGYKAL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-07-24" modified="2026-01-28" version="127" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B563</accession>
    <accession>C8V976</accession>
    <name>SEC13_EMENI</name>
    <protein>
        <recommendedName>
            <fullName>Protein transport protein sec13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">sec13</name>
        <name type="ORF">AN4317</name>
    </gene>
    <organism>
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules. It also functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. Sec13 is required for efficient mRNA export from the nucleus to the cytoplasm and for correct nuclear pore biogenesis and distribution.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">The COPII coat is composed of at least 5 proteins: the SEC23/24 complex, the SEC13/31 complex, and the protein SAR1. Component of the nuclear pore complex (NPC). NPC constitutes the exclusive means of nucleocytoplasmic transport. NPCs allow the passive diffusion of ions and small molecules and the active, nuclear transport receptor-mediated bidirectional transport of macromolecules such as proteins, RNAs, ribonucleoparticles (RNPs), and ribosomal subunits across the nuclear envelope. Due to its 8-fold rotational symmetry, all subunits are present with 8 copies or multiples thereof.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">COPII-coated vesicle membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat SEC13 family.</text>
    </comment>
    <dbReference type="EMBL" id="AACD01000075">
        <property type="protein sequence ID" value="EAA60478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF77777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_661921.1">
        <property type="nucleotide sequence ID" value="XM_656829.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B563"/>
    <dbReference type="SMR" id="Q5B563"/>
    <dbReference type="FunCoup" id="Q5B563">
        <property type="interactions" value="1052"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5B563"/>
    <dbReference type="EnsemblFungi" id="CBF77777">
        <property type="protein sequence ID" value="CBF77777"/>
        <property type="gene ID" value="ANIA_04317"/>
    </dbReference>
    <dbReference type="GeneID" id="2872114"/>
    <dbReference type="KEGG" id="ani:ANIA_04317"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN4317"/>
    <dbReference type="eggNOG" id="KOG1332">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032441_0_1_1"/>
    <dbReference type="InParanoid" id="Q5B563"/>
    <dbReference type="OMA" id="IWKEEGD"/>
    <dbReference type="OrthoDB" id="364224at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061700">
        <property type="term" value="C:GATOR2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090114">
        <property type="term" value="P:COPII-coated vesicle budding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051664">
        <property type="term" value="P:nuclear pore localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902953">
        <property type="term" value="P:positive regulation of ER to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070863">
        <property type="term" value="P:positive regulation of protein exit from endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032008">
        <property type="term" value="P:positive regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032527">
        <property type="term" value="P:protein exit from endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000017">
        <property type="entry name" value="SEC13 homolog (S. cerevisiae)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037363">
        <property type="entry name" value="Sec13/Seh1_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN SEC13 / SEH1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024:SF2">
        <property type="entry name" value="PROTEIN SEC13 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword id="KW-0931">ER-Golgi transport</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0509">mRNA transport</keyword>
    <keyword id="KW-0906">Nuclear pore complex</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-0653">Protein transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0811">Translocation</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <keyword id="KW-0853">WD repeat</keyword>
    <feature type="chain" id="PRO_0000295415" description="Protein transport protein sec13">
        <location>
            <begin position="1"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 1">
        <location>
            <begin position="11"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 2">
        <location>
            <begin position="55"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 3">
        <location>
            <begin position="110"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 4">
        <location>
            <begin position="155"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 5">
        <location>
            <begin position="216"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 6">
        <location>
            <begin position="264"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="Q04491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="309" mass="34072" checksum="7D485BB22CED996B" modified="2005-04-26" version="1">MAAAQVISNSGHDDMIHDAGLDYYGRRLATCSSDKTIKIFEIEGDTHKLVETLKGHEGPVWCVEWAHPKFGTILASSSYDGKVLIWREQHQSSTAPIGSGAWTKVFDFSLHTASVNMISWAPHETGCLLACASSDGHVSVLEFRDNSWTHQIFHAHGMGVNSISWAPAASPGSLVSSNPGIGQQRRFVTGGSDNLLKIWDYNPETKTYNATQTLEGHSDWVRDVAWSPSILSKSYIASASQDKTVRVWTADASNPGQWTSQVLEFDNVLWRVSWSPSGNILAVSGGDNKVSLWKENLRGQWEKVKDIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="105" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B5A7</accession>
    <accession>C8V403</accession>
    <name>Q5B5A7_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">C2 domain protein (AFU_orthologue AFUA_7G03800)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_04273</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF74345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_661877.1">
        <property type="nucleotide sequence ID" value="XM_656785.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B5A7"/>
    <dbReference type="STRING" id="227321.Q5B5A7"/>
    <dbReference type="GeneID" id="2873695"/>
    <dbReference type="KEGG" id="ani:ANIA_04273"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN4273"/>
    <dbReference type="eggNOG" id="ENOG502S2KW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022666_2_0_1"/>
    <dbReference type="InParanoid" id="Q5B5A7"/>
    <dbReference type="OMA" id="SRYNFQA"/>
    <dbReference type="OrthoDB" id="73919at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010628">
        <property type="term" value="P:positive regulation of gene expression"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd04041">
        <property type="entry name" value="C2A_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037767">
        <property type="entry name" value="C2A_Mug190-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47800">
        <property type="entry name" value="C2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47800:SF5">
        <property type="entry name" value="FER-1-LIKE PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="2">
        <location>
            <begin position="42"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="485"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="502"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="523"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF74345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="584" mass="66411" checksum="C44325E4F545BE1F" modified="2005-04-26" version="1">MADTQSHIRPQHLGDKYGPRLVDKAEKLQNQAVAMAVGSKSDSSEPAGGFDSTPFPYAPPGFTLRFTFHRGVNLPVADFGTFSSDSYLVASLAVDVPQRHKQDPLPTYRTPTVRKNRDPVWEKEWTVANVPACGFRLKCRVYDEDAADHDDKLGNAYIQVDSISAQWPGIQQQPFRLKKHTGSKRVYLFGNVAAIASRRLHTDPHLVISVECLGKTPGTNGAQVYTVGPNYWFKHFSPLIGRLTGTKDAVQSQDGRKTVNRYNFQAIQIQLKGPVPKELYHRYVEFKPFVAGMFTSHTLRGRILNRALHHQHERIYNFDRATLDGQFDEPCLELTQKFLEFVHYAQGGRIFTYVLTLDGQLRFTETGKEFGIDLLSKHTMHSNVSIYIAYSGEFFVRQRKHNHRMQSLVSNSSSTEYIMDNDGEEMEVSTDPTKYELFIDNDSGTYRPNAKYLPLLKQFISSNFPGLHITTLDCQADAERMERLKNEQREQKNRARGQMAFLQQRSRSSSSLSISSSDEDELNEHSGLENKKRGDFARKVHEMRDVKSQVLRWAQADQDEGARKNATMSSRPPEGAPDQKNPQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B5U1</accession>
    <accession>C8V5B9</accession>
    <name>Q5B5U1_EMENI</name>
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        <recommendedName>
            <fullName evidence="3">DUF3074 domain-containing protein</fullName>
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    </protein>
    <gene>
        <name evidence="4" type="ORF">ANIA_04089</name>
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    <organism evidence="4 5">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF74728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_661693.1">
        <property type="nucleotide sequence ID" value="XM_656601.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B5U1"/>
    <dbReference type="STRING" id="227321.Q5B5U1"/>
    <dbReference type="GeneID" id="2873514"/>
    <dbReference type="KEGG" id="ani:ANIA_04089"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN4089"/>
    <dbReference type="eggNOG" id="ENOG502S6FW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022947_0_0_1"/>
    <dbReference type="InParanoid" id="Q5B5U1"/>
    <dbReference type="OMA" id="MNPVEWI"/>
    <dbReference type="OrthoDB" id="5403181at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="CDD" id="cd08864">
        <property type="entry name" value="SRPBCC_DUF3074"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.530.20:FF:000053">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024500">
        <property type="entry name" value="DUF3074"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051213">
        <property type="entry name" value="START_lipid_transfer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19308">
        <property type="entry name" value="PHOSPHATIDYLCHOLINE TRANSFER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19308:SF14">
        <property type="entry name" value="START DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11274">
        <property type="entry name" value="DUF3074"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3074" evidence="3">
        <location>
            <begin position="113"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="62"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="323"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="403"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="515"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="609"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="480"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="71"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="334"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="346"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="405"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="425"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="515"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="543"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBF74728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="681" mass="75144" checksum="1A1B989E109AD42D" modified="2005-04-26" version="1">MASLQDSLLSLNATTWDAIPSDQSSLREYIIDLRAKARLITDSVPEPPPSDTISTLNDIKLKPSPARLGTKNESTLANQKQWSKPIVKPTPNKDNPLGIPVYKLSGTDGQGHWFGRRSVHKGLPYSVWEKKLSSEMAETLRTNQERVQKGQAPDMAVRGIGAQRGLETIEVKDEDGEELVGKVNVYHVSASFPKPTTSRDFVVMIVTWDKGFVEYKRDDGDVIQKEEREGRSWMMVSKPVEHPDAPEGDEYIRGQYESVEMIREILMDKDGSETDAESETNPVEWTMVTRSNPGGTIPRWMVEKGTPKSICTDAAKFLEWASQDPEAATKAREQAQSPAGSKTSQVDGTAASAAVGDSSDSDSSLSSEYEQEEHHGLIASVGHLLNAGLERYAPQAVLDYIPTQSRQSSSSHATPSSKSNIINEHTPEPQQAKHEDAHDHDDGLSQASITSSLRAEETTPGDMLDISAAEILQRNRKGKLSSHERQLAKLAQEKRSVEAQIQLVRSDIHALGLRAPDEQEVKKETTSARASVDKPGSPISPNSSTNKLTSDSTSSSSATKNRSRSGTPAPASDTPQMHKVASGLFREEAKLVRRLSKIERHQIKEAAKIEARHRKEAEKEDKARSRDETEVLKREVEHLKKECERLKGERKQWLSLIKALQAENTKLARQGNAAAIDGNTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B6I9</accession>
    <accession>C8V6J2</accession>
    <name>Q5B6I9_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphoinositide phosphatase (Sac1), putative (AFU_orthologue AFUA_4G08050)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_03841</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF75263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_661445.1">
        <property type="nucleotide sequence ID" value="XM_656353.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B6I9"/>
    <dbReference type="SMR" id="Q5B6I9"/>
    <dbReference type="FunCoup" id="Q5B6I9">
        <property type="interactions" value="1331"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5B6I9"/>
    <dbReference type="GeneID" id="2873254"/>
    <dbReference type="KEGG" id="ani:ANIA_03841"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN3841"/>
    <dbReference type="eggNOG" id="KOG1889">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003016_7_4_1"/>
    <dbReference type="InParanoid" id="Q5B6I9"/>
    <dbReference type="OMA" id="ITKAQPV"/>
    <dbReference type="OrthoDB" id="405996at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005797">
        <property type="term" value="C:Golgi medial cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072517">
        <property type="term" value="C:host cell viral assembly compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017059">
        <property type="term" value="C:serine palmitoyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052629">
        <property type="term" value="F:phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004438">
        <property type="term" value="F:phosphatidylinositol-3-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043812">
        <property type="term" value="F:phosphatidylinositol-4-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061909">
        <property type="term" value="P:autophagosome-lysosome fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002013">
        <property type="entry name" value="SAC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45662">
        <property type="entry name" value="PHOSPHATIDYLINOSITIDE PHOSPHATASE SAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45662:SF2">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-3-PHOSPHATASE SAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02383">
        <property type="entry name" value="Syja_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50275">
        <property type="entry name" value="SAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="590"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="623"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="domain" description="SAC" evidence="2">
        <location>
            <begin position="118"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF75263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="706" mass="79767" checksum="426A9ADFC8DEF4FC" modified="2005-04-26" version="1">MVTSILPFRDINLHASPAHYAFTSPSSPDAPTLVVERPTGDLRLSNGSLSGAKRISSIAGILGIIKLKLDKYIIVITKAQPMGRLRGQMIYKVAGTEFLPLRERPLHDHDEDAYLTMLKELLRTGPMYFSYTLDITNSFQRQSQSDMSLPMWKRADDRFFWNRFIQSDLIDFSLGEHNTTSVRYGPQPGVDPYILPVIFGMLRITPAKVKSTTFTFALITRRSRHRAGTRYFSRGIDEQGNVSNYNETEQIVILNDATGGLSGFAGGQTITKEKPADLGQDPQVMSFVQTRGSVPVFWAEVNNLKYTPKLQVRGVETAVQAARKHFAEQIRLYGDNYLVNLVNQKGREERVKNAYEQLIRILVSSPNELTEADDESSEKLHVLEPDHPQKEMDRLHYVYFDFHNETKGLRWHRAELLMDRLINGLNQGGYFRGLENPGAAGGQLEARALQSSVVRTNCMDCLDRTNVVQSMLGRWALTRQLTEAGVLRPGEAANDDQEFEDLFRNIWADNADVVSKAYSGTGALKTDFTRTGQRTRAGMVQDLSNSITRYVRNNFLDGPRQDGFDVFLGAYLPPESTLGNLRIFVDRRPLIIQSIPYIFAAGLFMIIIALFTRRLPDAAVWPLRLFVVFWLLISGWCARFMLAHGMLYVNWPKLNTPAAGSEGYQDALIKARSDPVIGQLLPSRRHQRGYSNARLGFLEEGKTRIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="117" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B736</accession>
    <accession>C8V3W9</accession>
    <name>Q5B736_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein involved in error-free postreplication DNA repair (Eurofung)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_03644</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF75708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_661248.1">
        <property type="nucleotide sequence ID" value="XM_656156.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B736"/>
    <dbReference type="FunCoup" id="Q5B736">
        <property type="interactions" value="1088"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5B736"/>
    <dbReference type="GeneID" id="2873067"/>
    <dbReference type="KEGG" id="ani:ANIA_03644"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN3644"/>
    <dbReference type="eggNOG" id="KOG0896">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063065_4_0_1"/>
    <dbReference type="InParanoid" id="Q5B736"/>
    <dbReference type="OMA" id="GPESCSY"/>
    <dbReference type="OrthoDB" id="6508832at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031371">
        <property type="term" value="C:ubiquitin conjugating enzyme complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006301">
        <property type="term" value="P:DNA damage tolerance"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070534">
        <property type="term" value="P:protein K63-linked ubiquitination"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd23807">
        <property type="entry name" value="UEV_UBE2V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000026">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="2">
        <location>
            <begin position="8"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF75708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="141" mass="15818" checksum="EE0ABAA9D65718D1" modified="2005-04-26" version="1">MAANAKVPRNFRLLEELEKGEKGLGAEACSYGLADGEDMMMSNWNGTVLGPPHSVHENRIYSLNIHCGPEYPDQPPTLQFISRVNLPCVDAHSGKVDPSKLPCLAQWKRDYTMETVLIELRRYMALPQHKKLPQPPEGSTF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2018-05-23" modified="2025-02-05" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B7J0</accession>
    <accession>C8V551</accession>
    <name>INPC_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Acyl-CoA ligase inpC</fullName>
            <ecNumber evidence="3">6.2.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Fellutamide B biosynthesis cluster protein C</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Inp cluster protein C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">inpC</name>
        <name type="ORF">ANIA_03490</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2010" name="Appl. Environ. Microbiol." volume="76" first="8143" last="8149">
            <title>Activation of a silent fungal polyketide biosynthesis pathway through regulatory cross talk with a cryptic nonribosomal peptide synthetase gene cluster.</title>
            <authorList>
                <person name="Bergmann S."/>
                <person name="Funk A.N."/>
                <person name="Scherlach K."/>
                <person name="Schroeckh V."/>
                <person name="Shelest E."/>
                <person name="Horn U."/>
                <person name="Hertweck C."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="20952652"/>
            <dbReference type="DOI" id="10.1128/AEM.00683-10"/>
        </citation>
        <scope>IDENTIFICATION</scope>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2016" name="ACS Chem. Biol." volume="11" first="2275" last="2284">
            <title>Resistance gene-guided genome mining: serial promoter exchanges in Aspergillus nidulans reveal the biosynthetic pathway for fellutamide B, a proteasome inhibitor.</title>
            <authorList>
                <person name="Yeh H.H."/>
                <person name="Ahuja M."/>
                <person name="Chiang Y.M."/>
                <person name="Oakley C.E."/>
                <person name="Moore S."/>
                <person name="Yoon O."/>
                <person name="Hajovsky H."/>
                <person name="Bok J.W."/>
                <person name="Keller N.P."/>
                <person name="Wang C.C."/>
                <person name="Oakley B.R."/>
            </authorList>
            <dbReference type="PubMed" id="27294372"/>
            <dbReference type="DOI" id="10.1021/acschembio.6b00213"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>PATHWAY</scope>
    </reference>
    <comment type="function">
        <text evidence="5 9">Acyl-CoA ligase; part of the inp gene cluster that mediates the biosynthesis of fellutamide B, a mycotoxin that acts as a proteasome inhibitor (PubMed:20952652, PubMed:27294372). In the first step of fellutabmide B biosynthesis inpC activates 3-hydroxydodecanoic acid to generate 3-hydroxydodecanoyl-AMP that is then loaded onto the T0 domain of inpB (PubMed:27294372). The 3-hydroxydodecanoyl-S-phosphopantetheinyl-T0 is sequentially extended with L-Asn and L-Gln by the two CAT modules of inpB (PubMed:27294372). The linear lipodipeptide from inpB is then transferred onto inpA for the addition of the third amino acid, L-Leu (PubMed:27294372). Reductive releasing of the lipotripeptide by the TE domain of inpA produces (2S)-fellutamide B (PubMed:27294372). InpF might be involved in the release and transfer of the lipodipeptide from inpB to inpA (PubMed:27294372). The inp cluster-encoded proteasome subunit inpE confers resistance to internally produced fellutamides (PubMed:27294372). The MFS efflux transporter inpD may contribute to fellutamide resistance as well (PubMed:27294372).</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="induction">
        <text evidence="4">Expression is positively regulated by the secondary metabolism cross-pathway regulator scpR (PubMed:20952652).</text>
    </comment>
    <comment type="domain">
        <text evidence="2">Both substrate-binding domains (SBD1 and SBD2) are involved in the substrate recognition, and are sufficient to confer the substrate specificity.</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="5">Eliminates the production of fellutamides (PubMed:27294372).</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.-" evidence="3"/>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF76048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_661094.1">
        <property type="nucleotide sequence ID" value="XM_656002.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B7J0"/>
    <dbReference type="SMR" id="Q5B7J0"/>
    <dbReference type="STRING" id="227321.Q5B7J0"/>
    <dbReference type="EnsemblFungi" id="CBF76048">
        <property type="protein sequence ID" value="CBF76048"/>
        <property type="gene ID" value="ANIA_03490"/>
    </dbReference>
    <dbReference type="GeneID" id="2872911"/>
    <dbReference type="KEGG" id="ani:ANIA_03490"/>
    <dbReference type="eggNOG" id="KOG1176">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_59_2_1"/>
    <dbReference type="InParanoid" id="Q5B7J0"/>
    <dbReference type="OMA" id="HRIGGIC"/>
    <dbReference type="OrthoDB" id="6509636at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.980">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.38.10">
        <property type="entry name" value="Luciferase, Domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF422">
        <property type="entry name" value="BCDNA.GH02901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000444110" description="Acyl-CoA ligase inpC">
        <location>
            <begin position="1"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="SBD1" evidence="2">
        <location>
            <begin position="280"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="SBD2" evidence="2">
        <location>
            <begin position="351"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="202"/>
            <end position="217"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="350"/>
            <end position="355"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="434"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="456"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="554"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="Q08AH3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="Q42524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="3">
        <source>
            <dbReference type="UniProtKB" id="Q5BA81"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="20952652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="27294372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="6">
        <source>
            <dbReference type="PubMed" id="20952652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="7">
        <source>
            <dbReference type="PubMed" id="27294372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="8"/>
    <evidence type="ECO:0000305" key="9">
        <source>
            <dbReference type="PubMed" id="20952652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBF76048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="583" mass="64205" checksum="5800D00D2046BE70" modified="2005-04-26" version="1">MIFTPPVWGPEMMAIPASRPIHEFLVERDSRHLYDWSEEKPALTIADRVDALARSLGRELGWSPNTGSPWSKVVGIFSFNTLDFLVASWAIHRIGGICMLMHPTSSAAEIKRHIELTECRVLFTCRSLLPTANEVLVASKVQDPRAYLLDLPEELGRKPSLPDQGQQTVEQLISAGATLPLIEALDWAEGQGKEQVAYLCPTSGTSGLQESALTVKKLAMITHYNIIANIIQATTFEAGPKKGRTEVALGFLPLSHSYGLILAHLTAWRGDTYILHARFDMQAALASIEKYRIERLYLVPPIISALVNNPFLLDLCDTSSVTSVVTGSGPFGPRLAEALSRVRPSWQVLPGYGLTETAVIISITDPNITYPGADGCLVPGVEARLINSNGNEVEAYNEPGELLLKSPSIMKGYLGQETATREVFDEQGWLRTGDIAVFRLTGQDGKVTPHLDIVDRKKDIMKVKGLQVAPVEIESHLAAHPAVAEVAVVGVRDEDAGERPYAFIVRSPRTMADLDEEALKADLNRHVEATLSEPHWLRKNIRFVEEFPKSSNGKPLKYKLKESLATSYARKTSPAIPNNTRNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="107" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B8D6</accession>
    <accession>C8VIB7</accession>
    <name>Q5B8D6_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Amidohydrolase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ANIA_03194</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF83217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_660798.1">
        <property type="nucleotide sequence ID" value="XM_655706.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B8D6"/>
    <dbReference type="STRING" id="227321.Q5B8D6"/>
    <dbReference type="GeneID" id="2874441"/>
    <dbReference type="KEGG" id="ani:ANIA_03194"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN3194"/>
    <dbReference type="eggNOG" id="KOG3968">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012358_2_1_1"/>
    <dbReference type="InParanoid" id="Q5B8D6"/>
    <dbReference type="OMA" id="WLVPVEP"/>
    <dbReference type="OrthoDB" id="194468at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019239">
        <property type="term" value="F:deaminase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016814">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01298">
        <property type="entry name" value="ATZ_TRZ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000014">
        <property type="entry name" value="5-methylthioadenosine/S-adenosylhomocysteine deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050287">
        <property type="entry name" value="MTA/SAH_deaminase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43794:SF11">
        <property type="entry name" value="AMIDOHYDROLASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43794">
        <property type="entry name" value="AMINOHYDROLASE SSNA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="4">
        <location>
            <begin position="57"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBF83217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="464" mass="50360" checksum="D0757F6E573155DD" modified="2005-04-26" version="1">MLFTHATILTLDSTRRIITDGAIYVPRGSNRISSLGKTAALLAQYPDEEKYDLTGRIVIPGLVSTHMHTAQTLLRGTADDLELVSWLCERIWVLQGNFTKDDGYAAARLSIAEMLKSGTTCFLESMFADRYGFEGLCQAVAESGIRGCLGKIVMDKGTYAADDAWAMHPGLIEDRETSLLGTVKMWEKWNGKADDRIRVWFGARTPGGVSDELYREMTAISREKNIPITMHCAEVKADRAFFGSVGHTPMTYCSSVGLLSPSTVLVHMVHLDDRDISLLSESGTHVAHCPTSNAKLASGTCRVPDLQTAGVNIGLGTDGAPCNNTCDLLQEMKLAAIIHKGASYDPTVVSAESVLEMATINGAKALGLDSEIGSLEVGKKADFVAIDTRGVSMQPWFNPVSAVVYTATGRDVDTVVVDGRVVVRNGELLTMDEGQIVKEAERRSREVVERAGLGEKVRPKWTVE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-09-23" modified="2026-01-28" version="106" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B8G3</accession>
    <accession>C8VIE7</accession>
    <name>NOP58_EMENI</name>
    <protein>
        <recommendedName>
            <fullName>Nucleolar protein 58</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">nop58</name>
        <name type="ORF">AN3167</name>
    </gene>
    <organism>
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for pre-18S rRNA processing. May bind microtubules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the NOP5/NOP56 family.</text>
    </comment>
    <dbReference type="EMBL" id="AACD01000051">
        <property type="protein sequence ID" value="EAA63738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF83273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_660771.1">
        <property type="nucleotide sequence ID" value="XM_655679.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B8G3"/>
    <dbReference type="SMR" id="Q5B8G3"/>
    <dbReference type="FunCoup" id="Q5B8G3">
        <property type="interactions" value="1553"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5B8G3"/>
    <dbReference type="EnsemblFungi" id="CBF83273">
        <property type="protein sequence ID" value="CBF83273"/>
        <property type="gene ID" value="ANIA_03167"/>
    </dbReference>
    <dbReference type="GeneID" id="2873782"/>
    <dbReference type="KEGG" id="ani:ANIA_03167"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN3167"/>
    <dbReference type="eggNOG" id="KOG2572">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015495_5_0_1"/>
    <dbReference type="InParanoid" id="Q5B8G3"/>
    <dbReference type="OMA" id="MGMRSNW"/>
    <dbReference type="OrthoDB" id="6780543at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031428">
        <property type="term" value="C:box C/D methylation guide snoRNP complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017069">
        <property type="term" value="F:snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000494">
        <property type="term" value="P:box C/D sno(s)RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902570">
        <property type="term" value="P:protein localization to nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000452">
        <property type="term" value="P:snoRNA guided rRNA 2'-O-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.246.90:FF:000003">
        <property type="entry name" value="Nucleolar protein 58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.4070:FF:000001">
        <property type="entry name" value="Probable Nucleolar protein 58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.4070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.90">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045056">
        <property type="entry name" value="Nop56/Nop58"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012974">
        <property type="entry name" value="NOP58/56_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042239">
        <property type="entry name" value="Nop_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002687">
        <property type="entry name" value="Nop_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036070">
        <property type="entry name" value="Nop_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012976">
        <property type="entry name" value="NOSIC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894">
        <property type="entry name" value="NUCLEOLAR PROTEIN 5 NUCLEOLAR PROTEIN NOP5 NOP58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894:SF1">
        <property type="entry name" value="NUCLEOLAR PROTEIN 58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01798">
        <property type="entry name" value="Nop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08156">
        <property type="entry name" value="NOP5NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00931">
        <property type="entry name" value="NOSIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89124">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51358">
        <property type="entry name" value="NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0690">Ribosome biogenesis</keyword>
    <keyword id="KW-0698">rRNA processing</keyword>
    <feature type="chain" id="PRO_0000350984" description="Nucleolar protein 58">
        <location>
            <begin position="1"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="domain" description="Nop" evidence="2">
        <location>
            <begin position="285"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="464"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="464"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="499"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="549"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="586" mass="63772" checksum="8095F75DB6B0599C" modified="2005-04-26" version="1">MTLFILTETSAGYALLKAKDKKLLKRDDLATEASTAEGVSNLLKLKSFQKFDSATAALEEVASVVEGKVTPRLASLLDEIKDEKKVSLAVADPKLGNAIGKLPGLDISLIADSTTADIYRAIREHLPTLIPGLLPQDMSTMSLGLSHSLARHKLKFSPDKIDTMIVQAIGLLDDLDKELNNYAMRVKEWYGWHFPELAKILNDNIAYSRLVLKMGMRSNFENADLAEILPEEIEAAVKAAADRSMGTEISEDDLENIQALAEQVVGFSEYRSQLAGYITARMNAIAPNLTALVGDLVGARLIAHAGSLTNLSKSPASTLQILGAEKALFRALKTKHDTPKYGLIYHASLIGQATGKNKGKMARVLAAKASLGLRVDALAEWDDDVTEEDKAALGTEARFNLERKLAALEGKPLKPRGVAIGPDGASAQPGKFNINEARKYNPDADAVDQDKATPSKKMLVQEVQDEEMADADSDEEPAANGVDSDSSDEETSKKSKKSKGSEIEKLAEKAGLSVKRYKRKLERGEIQFDAAGNPSAISKKDIKKAKKEAKKEAKKASKGDDKEKKRKRSDETEDTDGKKKKKKRDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B8X1</accession>
    <accession>C8VIW4</accession>
    <name>Q5B8X1_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Six-hairpin glycosidase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_03009</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF83573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_660613.1">
        <property type="nucleotide sequence ID" value="XM_655521.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B8X1"/>
    <dbReference type="STRING" id="227321.Q5B8X1"/>
    <dbReference type="GeneID" id="2873734"/>
    <dbReference type="KEGG" id="ani:ANIA_03009"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN3009"/>
    <dbReference type="eggNOG" id="ENOG502QSHV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024197_0_0_1"/>
    <dbReference type="InParanoid" id="Q5B8X1"/>
    <dbReference type="OMA" id="KFHMEMY"/>
    <dbReference type="OrthoDB" id="3534988at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010175698" description="Six-hairpin glycosidase-like protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="698"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF83573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="698" mass="78258" checksum="C04E94F622B90BA6" modified="2005-04-26" version="1">MFSLHLFLGPLLLALTTINASTTQKEPRMVRKDVVRQYNPVRTSLSTTTPVQVGNGDFAFGADITGLQTLLAFNILSSWCWCNDSLPTAPNQTEPSDFTGMDWWTHGRLVNYNIHNPAEAEILQWLVANPHRVNLGRVGFLYKGRNISVEEVNDAVQTLDLYSGILTSEFTLQGERVSVTTVGDPESDIVAVDVQSSLLQYGSLVVFFDYPLTTGTNKFEAPFVGNWAAVSAHDTSLNSITEQKSVIRHLLGGTSYFNAIRWEQKGNLSGPFEGTHRYLLQPAGESSRFTFSTGFSPSRKVQIKPFASVQKASMKWWAQYWESGAFVDLTRSGSSDAEELQRRIILSQYLLAVDSAGKDPPQESGLQNNGWYGKFHLEMVFWHLGHWARWNKWDLLHRSLDVYERFLPSSIERAQKQGYAGARLGKMSDPTGTSAPGPQNALLIWQQPHPMFFAELEYRLWPNSTTLHKWGHLLDELATWMVSYAWWNASTQVYDLGPPMYPSSENTSPNSTYNPTFELAYWRFGLKIASDWRMRQDIPVPESWTRVLHNLAPLPIVDGGYSISADLPDMWTNAAYTADHPSQIAVYGLLPPTAAEECIRCQCYHESDYGNLGFQQVLWLGFPDARDDIASFRGREPGCRVVTGFALPVRRCWESCGYGCAYTVLSGVVRLAACGCNDGWRMGWSRGHAFSEALGAKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="107" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B9K3</accession>
    <accession>C8VJM3</accession>
    <name>Q5B9K3_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ANIA_02777</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAH family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF84034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_660381.1">
        <property type="nucleotide sequence ID" value="XM_655289.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B9K3"/>
    <dbReference type="STRING" id="227321.Q5B9K3"/>
    <dbReference type="ESTHER" id="emeni-q5b9k3">
        <property type="family name" value="6_AlphaBeta_hydrolase"/>
    </dbReference>
    <dbReference type="GeneID" id="2874317"/>
    <dbReference type="KEGG" id="ani:ANIA_02777"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN2777"/>
    <dbReference type="eggNOG" id="KOG1454">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1535">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_436837_0_0_1"/>
    <dbReference type="InParanoid" id="Q5B9K3"/>
    <dbReference type="OMA" id="DHKQFFL"/>
    <dbReference type="OrthoDB" id="194468at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018773">
        <property type="term" value="F:acetylpyruvate hydrolase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050163">
        <property type="term" value="F:oxaloacetate tautomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006107">
        <property type="term" value="P:oxaloacetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.850.10:FF:000002">
        <property type="entry name" value="2-hydroxyhepta-2,4-diene-1,7-dioate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000807">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="entry name" value="Fumarylacetoacetase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820">
        <property type="entry name" value="ACYLPYRUVASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820:SF7">
        <property type="entry name" value="ACYLPYRUVASE FAHD1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="FAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarylacetoacetase-like C-terminal" evidence="4">
        <location>
            <begin position="77"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="342"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBF84034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="587" mass="62655" checksum="4653AD5BDA00487C" modified="2005-04-26" version="1">MVFNYCAYADPATGEDRIGHLDHQSLQIQPLSFTSGTRITNLYQVIEAGQASIVSARAEPLPLSSVKLLPTISGRDILAVGKNYVEHAKEFNSSGFDSSDKVDQPTAPVIFTKRATSIIAHGEDVLLHPGFTETPDYEGEIGVIIGKAGHKIPEDQAMDYVWGYTIINDFTARERQRDHKQFYIGKSPDTYCPIGPVAVPKEQLPEKENIRLQTFVNGEKRQDATLDQLIFSIPNLVSTLSQGQTIQPGDTIATGTPYGVGFGFRPMKFLKAGDEVKVSVTGLGSLVNRMAALDAPNPTIERVQASTSIHTANQKARGNNGLVKVGSKQLFYQFQGQKDGTPVIFIHGLGGSSSYFTPLLDKLSATHALHLTDLEGHGLSPTSALSSLTISSFAGDIRDVYILAAGSNPKPATVIAHSMGCLIALKLALENLNLVSNLVLLGPPPSPLPEAGSNGSFARAETVRAQGMAAVADAVVNAGLSSKTKSSNPLAVTATKLSLLGQDPEGYAKACMALARSAEETLDVEEVAAKTLILTGTADAVSPPALCEKYGQRIKDSTVVVLEDVAHWHLFEHVEGVRGAIYQFLGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B9W1</accession>
    <accession>C8VKF1</accession>
    <name>Q5B9W1_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Sphingoid long-chain base transporter RSB1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ANIA_02669</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
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                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
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                <person name="Visser J."/>
                <person name="Oliver S.G."/>
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            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
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        <subcellularLocation>
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    <evidence type="ECO:0000256" key="1">
        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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            <dbReference type="ARBA" id="ARBA00022989"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="CBF84243.1"/>
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    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    </evidence>
    <sequence length="341" mass="37741" checksum="5BCDDBE44E9F01A8" modified="2005-04-26" version="1">MMETLPTNQTLLEDPSLCTLDTCPLSMASFEYIPKLWAQILFMALFGLAFVVQLFLGIRYKTYTFMVAMVLGLAGEVVGYGGRVSLHDNPFNDDAFLQYLVSLTIAPAFLTAAIYLTLSRIVVAYGERISFFKPRTYTITFITFDFIALLLQAVGGAIASTADDDDRDMTDLGINIMIAGLAWQVASLLIFIAMSTYFFLRVRKAPGADLNLNFDTLRRSRYFKGSLWGLSIATIVILVRSIFRCAELSEGFDGELANDEVTFMILEAAMIGIAAICLTVFHPGVVWKGQWNQAVWSTRGKSGKTYAKASTADGDSEVSLRSMGMQARTAYPETSYQPYNP</sequence>
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<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BAB3</accession>
    <accession>C8VPJ7</accession>
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        <name evidence="2" type="ORF">ANIA_02517</name>
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        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
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            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF87012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_655029.2"/>
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        <property type="component" value="Chromosome VII"/>
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    </evidence>
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        <source>
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    <sequence length="419" mass="46446" checksum="5EE1A061DF6A165C" modified="2005-04-26" version="1">MVPPTPQDLGISSQYRQVPQYAQGQVTFDSRAVAAPDNAHYQSYSFSPNFYTPQHIPIPDAFPQTHSPQPSQQSSRPASYQPQQLHQNSLSQYTITPGFPDDPTHPSLSFPNEFTQPQRAPEQTINPQFISTPQPMNQSSSLNNQNQFVYVNPAEDPKMFSYFPDNVHLQPILPQPEVNNSLASDHISTVGSPAINGIKSVPAIAPAKPAPSKTKQAGIKKQPVTKKAPAKKADGKGSASSSSDSYESDSDLEIQEPEEPSPLPPTRPAEPEAAAQYDVLQAVWSPRNRRPKVDKVKAALVAFKDVVKNLRDSWKETAQALKAAENKGESSDTAQLRKQVAHQRRLMEVAVIATLEKGHPMIVEKYVIPLLLGFAYLAYCRHGHRSQKRIERISHVISLIWLPSCLKESYRGRVSLTLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="103" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BB84</accession>
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            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
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            <taxon>Aspergillaceae</taxon>
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    <reference evidence="10" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
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            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF86363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_659800.1">
        <property type="nucleotide sequence ID" value="XM_654708.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BB84"/>
    <dbReference type="FunCoup" id="Q5BB84">
        <property type="interactions" value="64"/>
    </dbReference>
    <dbReference type="GeneID" id="2875653"/>
    <dbReference type="KEGG" id="ani:ANIA_02196"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_2_0_1"/>
    <dbReference type="InParanoid" id="Q5BB84"/>
    <dbReference type="OMA" id="ARVCTFA"/>
    <dbReference type="OrthoDB" id="1935484at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000106">
        <property type="entry name" value="MFS transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF104">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="245"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="278"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="355"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="393"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="421"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="451"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="509"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="116"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBF86363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="555" mass="62894" checksum="662DBBA9294299F5" modified="2005-04-26" version="1">MAVDEKKTPPISTGEVEADSRGVSEIDDSDREQGRSGFKKGTFNATEDPRFYKPIDTYEGLHRWDPDFEWTEEEERRIVRKVSPQLPMAIKDNIKIINHQKTKEKKAKRDQIDARVCTFACVTFFALQLDRGNIGNALADNLLQDLHMTTNDYNTGQTIFLCCFLFAELPSQLISKRLGPDRWIPIQMVAWSLVAACQAFLKTRSGYLGLRALLGLLEGGFIPDTILFLSFFYKSSELPKRLTCFWVSYTVTTIIGAFLAFGLLHIKDSNGGGSWRYLFAYEGLLTGVIGIIAAFWMPASPTQTKGGFRGKGGWFTEHEEKIMVNRVIRDDPSKGSMHNRQAVTPRLLWDSLKDYHMWPIYILGFVWMIPYTPETNYLTLQLRSQGFTTFQTNLLTIPAAVVSITTMITTTWLAERTNQRLLFGAAIEVWYLVLLIALQTLPEKSMPWPRFAILTLIVGGPSLHPVLVALTSRNAGSVRTRTVASALYNMSVQVYRTEDQPYYRKGNKVLIALAVVSIFLFISAKVYYVWRNNLIPCDGLTSADAWIRIDFTFAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="130" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BBL9</accession>
    <accession>C8VLN7</accession>
    <name>Q5BBL9_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Alcohol dehydrogenase, putative (AFU_orthologue AFUA_2G04590)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">ANIA_02061</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF86100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_659665.1">
        <property type="nucleotide sequence ID" value="XM_654573.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BBL9"/>
    <dbReference type="STRING" id="227321.Q5BBL9"/>
    <dbReference type="GeneID" id="2874838"/>
    <dbReference type="KEGG" id="ani:ANIA_02061"/>
    <dbReference type="eggNOG" id="KOG0023">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_624081_0_0_1"/>
    <dbReference type="InParanoid" id="Q5BBL9"/>
    <dbReference type="OrthoDB" id="2209940at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000039">
        <property type="entry name" value="Alcohol dehydrogenase AdhP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.150:FF:000005">
        <property type="entry name" value="UPF0303 protein Ping_1243"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.150">
        <property type="entry name" value="Haem-degrading domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005624">
        <property type="entry name" value="PduO/GlcC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038084">
        <property type="entry name" value="PduO/GlcC-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G04590)-RELATED"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03928">
        <property type="entry name" value="HbpS-like"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="GlcG-like"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="11">
        <location>
            <begin position="57"/>
            <end position="143"/>
        </location>
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    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="10">
        <location>
            <begin position="183"/>
            <end position="253"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00004496"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CBF86100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="439" mass="46273" checksum="03E2127F42F511EB" modified="2005-04-26" version="1">MAEIPKVQTVALVREIGGPVEFPNDYPVPTPGNNEVLAKVLYTGDAVAPGPDGIPITKFKLPHIGGHEGVGRIVALGPGCGPDLKLGTLVGIRFASRVCRRCEYCLAGTEQYCLKGTNHLHHEDGSFQEYIALDADYLTILPDDVDPKTIAPVLCAGITAYKAVLGANIRAGHWLVVVGAGGGLGHMAVQYAKVLGAQVIGIDAPDKRDFVLSVGATEFVDFVNTDPVQRVHEITGLGAHSAVVTAGSGKAFAHPRELAAQESSPSTIFNSFTSNTAFKLGLALRTRILSLPSSQRKPALISISLGGSNGPTGAPHVVFQCATEPGTVPDNEVWVRRKRNTVERWGVSSWLMRRKIFAGLEGASADGIGAEEAFVRKYALVSSSGGKIADDYAIHGGGFPIRVKGVDGIVGVVVVSGLKQEDDHQVIVEVVQELIAQGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BBR1</accession>
    <accession>C8VLE7</accession>
    <name>Q5BBR1_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ANIA_02019</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF86023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_659623.1">
        <property type="nucleotide sequence ID" value="XM_654531.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BBR1"/>
    <dbReference type="STRING" id="227321.Q5BBR1"/>
    <dbReference type="GeneID" id="2875018"/>
    <dbReference type="KEGG" id="ani:ANIA_02019"/>
    <dbReference type="eggNOG" id="ENOG502STNU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1815476_0_0_1"/>
    <dbReference type="InParanoid" id="Q5BBR1"/>
    <dbReference type="OMA" id="KRRCQEW"/>
    <dbReference type="OrthoDB" id="5271495at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046670">
        <property type="entry name" value="DUF6540"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20174">
        <property type="entry name" value="DUF6540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF86023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="135" mass="14908" checksum="279BEAD90BCBC392" modified="2005-04-26" version="1">MTPTHELYIPISGLGLTPTSCSHWSFFLRTPGASYGDLLHIQPISLSPLWFQFDACEGIDISSLQAEGMVKIADLTSEQRRHAVKIIRSEPAPRDGKRRCQEWVVDVLVSLEVEELVTKTLDIGQASSNSAGVRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BCB6</accession>
    <accession>C8VPM4</accession>
    <name>Q5BCB6_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_01814</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF85613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_659418.1">
        <property type="nucleotide sequence ID" value="XM_654326.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BCB6"/>
    <dbReference type="GeneID" id="2874675"/>
    <dbReference type="KEGG" id="ani:ANIA_01814"/>
    <dbReference type="HOGENOM" id="CLU_1777410_0_0_1"/>
    <dbReference type="InParanoid" id="Q5BCB6"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF85613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="146" mass="16031" checksum="AD9B2EB4D8234B8E" modified="2005-04-26" version="1">MPIFPHLGLPPTASDLPSLTIDHNSFAMSSAASPAGHSTANGAARPDAQAPLPVLSRSLLVEHQARGKEGILKDPCFYMINAVNERVSKDLEGYGFGHRDLDKVLVRFFRYVFESMNPDLEKAWKTYKKKSDSPEYADGPTQAQGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="134" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BCD3</accession>
    <accession>C8VPF6</accession>
    <name>Q5BCD3_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ANIA_01797</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF85580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_659401.1">
        <property type="nucleotide sequence ID" value="XM_654309.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BCD3"/>
    <dbReference type="FunCoup" id="Q5BCD3">
        <property type="interactions" value="196"/>
    </dbReference>
    <dbReference type="GeneID" id="2875001"/>
    <dbReference type="KEGG" id="ani:ANIA_01797"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_1_1"/>
    <dbReference type="InParanoid" id="Q5BCD3"/>
    <dbReference type="OMA" id="GCYRIPV"/>
    <dbReference type="OrthoDB" id="5141738at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd17356">
        <property type="entry name" value="MFS_HXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF40">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="322"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="353"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="388"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="425"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="21"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBF85580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="512" mass="55627" checksum="045651BBBD907503" modified="2005-04-26" version="1">MGFMLRKPDDAAGSAAPAILIGLFVAFGGVLYGYDTGTISGILAMKYWRRQFSTGYVNPNDHIPDVTSSQSSMIVSLLSAGTFFGALTAAPVADYFGRRIAMILDCFVFCFGVVLQTAATAIPLFVAGRFFAGFGVGLLSATVPLYQSETAPKWIRGTIVGAYQLAITIGLLLAAIVNNSTKDRNDTGCYRIPVAVQFAWAIILVVGMIILPETPRFLIKQDNHEAAIKSLARLRRLDINDLAVVEELEEIKANHEYELSVGKASYLEILRGSIVTVYYGTTFFQHSGINNSFVITLITNIVNVVSTLPGLWMVEKWGRRPLLLFGAVGMCVSQFIVAIVGTTTDSGVANKVLIAFVCVYIFFFASSWGPVAWVVTGELFPLKARAKCLSITTAANWLLNWAIAYATPYMVDSGPGNANLQSKVFFIWGGFCLIAGIFVWTCIYETKGLTLEEVDELYAKVPVAWRSKGFVPSVHYTDVRDVAAGRKGSGLAELEADAQAKQISEHVEKASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="109" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BCK6</accession>
    <accession>C8VP23</accession>
    <name>Q5BCK6_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ANIA_01724</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF85438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_659328.1">
        <property type="nucleotide sequence ID" value="XM_654236.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BCK6"/>
    <dbReference type="GeneID" id="2875542"/>
    <dbReference type="KEGG" id="ani:ANIA_01724"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN1724"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_27_4_1"/>
    <dbReference type="InParanoid" id="Q5BCK6"/>
    <dbReference type="OMA" id="FIMPNAV"/>
    <dbReference type="OrthoDB" id="440755at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:001179">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:001185">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF41">
        <property type="entry name" value="MFS TRANSPORTER OF UNKOWN SPECIFICITY (AFU_ORTHOLOGUE AFUA_5G09940)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="151"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="239"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="304"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="343"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="375"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="406"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="431"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="468"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="508"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="81"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="34"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="34"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBF85438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="576" mass="62560" checksum="1BCEE752E3FE9C44" modified="2005-04-26" version="1">MALVSTLHHELALPVPKLEPATTSPLFVSNETSLRQSADNTAEDTVTNNHQDAPVSPVQAEPGQTRQVFERAPLPESSRYRQLAITTLIVISNLVQMIVNFAGIAGGRTFIESMGVKQTYATWIAASYGLTQGTFVLVSGRLGDVYGHRKMLLGGGAWLVLCSFVGAFVHTNFFAFVTMRALAGVGGACIMPNAVAMIAITNPPGRVRNLSLGFFAASAPLGGYFSALFLGAFMEHTHWRWFFTFVACLGAVTFIPLWLLSNNQATSSRNEKIDWLGAALGTSALILFNFVWNQAPSVGWSTPYEIALLVLSVILFSFFIIWEHKISHPIMPPSIFRAPSFAILVLVILLDYMTVGTVLWYQLLWLQDVWGWSTLQFAIGWTPFVICGTFAACLAAWLIPRLAAQWILALGSVTVMVSTVLIATIPLKQSYWAQMFPSIVLFSFCPDLVYTAGQIIASNTVRRHQQGVAGSIIGTLNLYGNSLGLGFASTVEVQIAKTSGNNITGYRAALYFGVAISAIALLLDVAFVRRVKDEREGWEEGDQDGEAIELAQAATTGAQVSRLEAGQGSSVVQRVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BCP4</accession>
    <accession>C8VNT5</accession>
    <name>Q5BCP4_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ANIA_01686</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF85367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_659290.1">
        <property type="nucleotide sequence ID" value="XM_654198.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BCP4"/>
    <dbReference type="STRING" id="227321.Q5BCP4"/>
    <dbReference type="GeneID" id="2875685"/>
    <dbReference type="KEGG" id="ani:ANIA_01686"/>
    <dbReference type="eggNOG" id="ENOG502S3WG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_438673_0_0_1"/>
    <dbReference type="InParanoid" id="Q5BCP4"/>
    <dbReference type="OMA" id="PQSWHPY"/>
    <dbReference type="OrthoDB" id="2247093at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="BZIP" evidence="3">
        <location>
            <begin position="500"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="369"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="491"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="554"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="295"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="393"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="405"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="491"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="554"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBF85367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="653" mass="70291" checksum="F700BD9E1886EDEC" modified="2005-04-26" version="1">MDADLAVANNTNRWPGARKPLSAAGQSCEPRTTRFVFLGLSVGAMLSLLCSMMVHSQYCTFTPLDVILYRQTSLTAHDHPIDLAVSSVAVVDLAALKPYPPRPGFDPVWPVYSLPPPLPLVLTSPSYSSHPLRSRQYHSLSDYHLAQSVPGSLSRAPLHESPSTLSEREGAPPCPGLPLQRSTESNAEHMSKNPPVSAPSPTGAHSRESRGSLERKRRHTNDEFSPTTECRDAVRPRPLSWHPSAPVEPPLQPSQHRPIGVSSILNQPATETPDIRTATGDSGHEGPGERLSVDPPSHSRFPSSSSIHLPSPSINPANPTVLSPAITNRQGISPVSPSARFVGAAGYFPAKSGLGQPPLAQQLPRLHTVAPSSPLPMTDTSNPPPVSGHHHQTSTNSTSTYTSHRASTNHTPTPGSKEASPTTPASVLSQIGRSSPGISATTAPHSASVYMNTPMYTAVDPITRLPIVVAGQRASGIEAPPGMIPCYVDHKPGSSTQAEKRKANSNASRRFRDRKRNEMQMEQKITAQQDEIRKLTETVQKQADELRVAVEQRDFYRSERDYFRDQASRFGQIPARPISPKLLRPASEATGGSDDKAEETTTDSSSHQRTPGPIAPAPMSGADWSGPLPYPSGPTEPQTRPMASTPAAWDRTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BCP8</accession>
    <accession>C8VNT0</accession>
    <name>Q5BCP8_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Helix-turn-helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_01682</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF85358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_659286.1">
        <property type="nucleotide sequence ID" value="XM_654194.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BCP8"/>
    <dbReference type="STRING" id="227321.Q5BCP8"/>
    <dbReference type="GeneID" id="2875077"/>
    <dbReference type="KEGG" id="ani:ANIA_01682"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN1682"/>
    <dbReference type="eggNOG" id="ENOG502SEWH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087328_0_0_1"/>
    <dbReference type="InParanoid" id="Q5BCP8"/>
    <dbReference type="OMA" id="QFDPRRN"/>
    <dbReference type="OrthoDB" id="4085451at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054448">
        <property type="entry name" value="HTH_put_ascomycetes"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22943">
        <property type="entry name" value="HTH_68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helix-turn-helix" evidence="2">
        <location>
            <begin position="156"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF85358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="203" mass="21642" checksum="042DBC8ACADADFE5" modified="2005-04-26" version="1">MGSSASKPARSAAQASRRQYPKQPSAPSPASRPPTQRPPPPAPSPASRQPKIPPQSPAQGPTYHSKEKASLEKSSAIDLDGRDPHFAASLRSIGPVTPNPTLSHSSTFNQTHPPSVFPSTSTNPALLAVTARQRITREAEAEAEELGKGGFEGRRYLDAYTIRQILAMRDRQGLGAEEIERALRLKRGIVGRVGAAKGVFGVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BCW2</accession>
    <accession>C8VNB5</accession>
    <name>Q5BCW2_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_01618</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF85232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_659222.1">
        <property type="nucleotide sequence ID" value="XM_654130.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BCW2"/>
    <dbReference type="GeneID" id="2875064"/>
    <dbReference type="KEGG" id="ani:ANIA_01618"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN1618"/>
    <dbReference type="HOGENOM" id="CLU_1938129_0_0_1"/>
    <dbReference type="InParanoid" id="Q5BCW2"/>
    <dbReference type="OrthoDB" id="3552888at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35605">
        <property type="entry name" value="ECP2 EFFECTOR PROTEIN DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35605:SF1">
        <property type="entry name" value="ECP2 EFFECTOR PROTEIN DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010212215" evidence="1">
        <location>
            <begin position="20"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF85232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="130" mass="14348" checksum="EA6B42409CFDC6D0" modified="2005-04-26" version="1">MFSPLTLAILAICIAVSSSLTVGCYPEDYQIVQNDLFDGLYSLKNDQISNLQPGTCERVVCNSNAAVYWCNDNEDRHAEVKSKQVGDAAWKIIHDCGISAHTLIYAAGVVVYPTKIRVVVIKDDECLDQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="109" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BCW4</accession>
    <accession>C8VNB3</accession>
    <name>Q5BCW4_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ANIA_01616</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF85228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_659220.1">
        <property type="nucleotide sequence ID" value="XM_654128.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BCW4"/>
    <dbReference type="GeneID" id="2874625"/>
    <dbReference type="KEGG" id="ani:ANIA_01616"/>
    <dbReference type="eggNOG" id="KOG1575">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_2_2_1"/>
    <dbReference type="InParanoid" id="Q5BCW4"/>
    <dbReference type="OMA" id="KANEPFW"/>
    <dbReference type="OrthoDB" id="48988at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19146">
        <property type="entry name" value="AKR_AKR9A1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF7">
        <property type="entry name" value="NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="4">
        <location>
            <begin position="30"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="4">
        <location>
            <begin position="309"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBF85228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="404" mass="45084" checksum="CECAD00991CD6E84" modified="2005-04-26" version="1">MSMFPPAPKPPTLLGYHRVLSPSAGVKVSPLCLGAMNFGDAWKEYMGECNKEQTFALLDAFYEAGGNFIDTANNYQQEESEKWIGEWLKKRGNRDQMVIATKYTTGFRTSHRATEPLQSNFVGNSFKSMRVSVDNSLRKLQTDYIDILYLHWWDFTTSVEEVMHGLNSLVTAGKVLYLGVSDTPAWVVVKANDYARAHGLKPFSVYQGKWNAAYRDMEREIVPMCRDQGMGIAPWAPLGGGKFKSAEARKAASSGGSNRGAEMSESDIRISDALEKIAERKKTTLHAIVSHPCQYPYLYSITDQCPCQALAYVMHKTPNVFPIVGQRKIEHLKANIEALSISLSDADMDEIDGATEFDVGFPMSFIFREFTGRNTAADVWLTKASALIDAPPQPGPVRHREAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BDB0</accession>
    <accession>C8VME1</accession>
    <name>Q5BDB0_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_01470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF84924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_659074.1">
        <property type="nucleotide sequence ID" value="XM_653982.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BDB0"/>
    <dbReference type="STRING" id="227321.Q5BDB0"/>
    <dbReference type="GeneID" id="2875154"/>
    <dbReference type="KEGG" id="ani:ANIA_01470"/>
    <dbReference type="eggNOG" id="ENOG502RS3Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036496_0_0_1"/>
    <dbReference type="InParanoid" id="Q5BDB0"/>
    <dbReference type="OMA" id="SLWDEFT"/>
    <dbReference type="OrthoDB" id="448954at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF84924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="469" mass="51780" checksum="002E33642391B882" modified="2005-04-26" version="1">MEPSGLARHVSKPLDHLINSGKTRESKHQIAILEDEDVETFVAFCEYAYTGNYAVPPPGSRENEIEPVSINHALNGAYPDTGSTSPAASWEKSPPKPKVPSEACPGNPDDSNDRDGVGDGDVEPRRDPSQQSSSKDRHVYHSTKSEYTAQNPVATPHDSDNSPAPWAEDPPTRGRRRRRGKKDQQGVTQDATSKLTPPCTPPGAAQVEPDMPAAEPSEEFPVLPGAEQSTSQSPERPGRTLSNGANGSGFGGIRNQREESLTKSRVRPVIDTSFANQQFSPRHEKGTTNLWEEFTGIDDSGFRPSFRTRSPNPPAGITLPYLIFHAKLYVFATRYLIPGLAHLCLQKLHYDLLNLAFPDPDPENQYEEQLVLTTTKARMIVDLLNYTYTKTTRLEPITPSSATQLRDNELRRLVVHYAACKVRDLAVYCPPVEPIAGAAFYPEQPSARGFRALLDTLPELASDLIYRMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="109" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BE02</accession>
    <accession>C8VSR3</accession>
    <name>Q5BE02_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">60S ribosomal protein L35 (AFU_orthologue AFUA_1G10510)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ANIA_01228</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL29 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF87895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_658832.1">
        <property type="nucleotide sequence ID" value="XM_653740.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BE02"/>
    <dbReference type="FunCoup" id="Q5BE02">
        <property type="interactions" value="864"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5BE02"/>
    <dbReference type="GeneID" id="2877009"/>
    <dbReference type="KEGG" id="ani:ANIA_01228"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN1228"/>
    <dbReference type="eggNOG" id="KOG3436">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_110381_1_1_1"/>
    <dbReference type="InParanoid" id="Q5BE02"/>
    <dbReference type="OMA" id="VMNQKAR"/>
    <dbReference type="OrthoDB" id="528635at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030684">
        <property type="term" value="C:preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00427">
        <property type="entry name" value="Ribosomal_L29_HIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.310:FF:000002">
        <property type="entry name" value="60S ribosomal protein L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.250.3450:FF:000001">
        <property type="entry name" value="60S ribosomal protein L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00374">
        <property type="entry name" value="Ribosomal_uL29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001854">
        <property type="entry name" value="Ribosomal_uL29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045059">
        <property type="entry name" value="Ribosomal_uL29_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036049">
        <property type="entry name" value="Ribosomal_uL29_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00012">
        <property type="entry name" value="L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45722">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45722:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL29-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00831">
        <property type="entry name" value="Ribosomal_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46561">
        <property type="entry name" value="Ribosomal protein L29 (L29p)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBF87895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="124" mass="14546" checksum="C511FDACDC989909" modified="2005-04-26" version="1">MSSKVKAGQLWGKSKDELTKQLDELKTELAQLRVQKITGGASSKSLRIHDVRKSIARVLTVINANQRSQLRLFYKNKKYLPLDLRPRLTRALRRRLTKHEATLKTERQRKKEIHFPQRKYAIKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="139" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BED3</accession>
    <accession>C8VTK3</accession>
    <name>Q5BED3_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein kinase, putative (AFU_orthologue AFUA_1G11930)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ANIA_01097</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF88151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_658701.1">
        <property type="nucleotide sequence ID" value="XM_653609.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BED3"/>
    <dbReference type="FunCoup" id="Q5BED3">
        <property type="interactions" value="171"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5BED3"/>
    <dbReference type="GeneID" id="2876874"/>
    <dbReference type="KEGG" id="ani:ANIA_01097"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN1097"/>
    <dbReference type="eggNOG" id="KOG0583">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015975_0_0_1"/>
    <dbReference type="InParanoid" id="Q5BED3"/>
    <dbReference type="OMA" id="GMAEWMT"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000985">
        <property type="entry name" value="Serine/threonine-protein kinase MARK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000567">
        <property type="entry name" value="Serine/threonine-protein kinase MARK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="324"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="133"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="271"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="498"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="30"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="133"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="206"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="277"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="360"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBF88151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="645" mass="71745" checksum="FFC1B81F59FF7550" modified="2005-04-26" version="1">MATVQRSSRSSGLRIETTFHHGSRNCWGNGEREGEWREADEHRAGNEGDRTNISHDYDAHRCGTDEESSVLSSLHSSTPPISVPRHDDSPSQDEIPHEIPHNPEDIGASSPFDSFLQQEQSSFGFDPALTVTQRGIQPERQLSQSERLSRARRFQPQRTSSLRNILPQDDDELVSGVSQLGFSPDSRRSHIRRAVPTVLSREGLSGSPNGDRPTSLTTVSTMSPVIDEVQTPPEASRGMLSPICMSSPTQTYHSPEDRSASWSGGSAVPFGSKLSRYRSGTTRSRRSTASSGKSPASAFLSMWSTREEPAPKPDDEGQMVGTEYVLGKIIGSGGFSVVKEAYKVEESGETRRLAVKIVKKQVADKTERENDAVQAEFDHEVRVWRYLSHPNVLSLDAVYETDYATFCFTKLHIGGTLFDLIRQNRQNRRKLTMDLAKKYTYQLACALRYLHEDARVVHRDIKLENCLLDPVELPDGTKTSNLVLCDFGMAEWINADNEDASSEPYGDAGDRPPLRNIGPSDSSTSVAGSLEYASPELLDSITGIIDPSVDVWAFGVIVFTLIVGSRPFQHSFQPRLISNIRHGVWDREAVLGDGADSEARRDALDLITNCLEMDCRKRWTVRDILSSRFVREFSVDSPSDNAWKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BFE9</accession>
    <accession>C8VRA3</accession>
    <name>Q5BFE9_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Integral membrane protein, Mpv17/PMP22 family, putative (AFU_orthologue AFUA_1G13840)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ANIA_00731</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peroxisomal membrane protein PXMP2/4 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF88890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_658335.1">
        <property type="nucleotide sequence ID" value="XM_653243.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BFE9"/>
    <dbReference type="STRING" id="227321.Q5BFE9"/>
    <dbReference type="GeneID" id="2876498"/>
    <dbReference type="KEGG" id="ani:ANIA_00731"/>
    <dbReference type="eggNOG" id="KOG1944">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049109_10_0_1"/>
    <dbReference type="InParanoid" id="Q5BFE9"/>
    <dbReference type="OMA" id="FFSMQAL"/>
    <dbReference type="OrthoDB" id="430207at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007248">
        <property type="entry name" value="Mpv17_PMP22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266:SF113">
        <property type="entry name" value="MEMBRANE PROTEIN, MPV17_PMP22 FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G13840)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2, PXMP2 MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04117">
        <property type="entry name" value="Mpv17_PMP22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="124"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBF88890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="305" mass="34310" checksum="43CA621E1C028949" modified="2005-04-26" version="1">MRHAFIRRPALSPSPSRSSAPPQARLQSRRYESNTPTQRQPDHATTPKSELPAQSHISIPPTPPPVPARAAPRSLRQIIQAGPLGRMGRSYSRFQEKRPYTTQVCSSIVIYLCGDLSAQFFFPPENPPQRRMESQPEKDDNGGVAEKKGGYDPWRTMRHLTVGIGSSIPSYNWFMFLHNNFNFASKPLSILTKVVVQQAVFTPVFNTYFFSVHSLLSGASLEETWERLKVALPRSIVNSAKFWPMVTAFSFMYVPPQFRNVFSGCIAVGWQTYLSWLNQKAARQVETALTEPAPSEEQVAVVIKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BGS0</accession>
    <accession>C8VUJ4</accession>
    <name>Q5BGS0_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA primase large subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">ANIA_00260</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="9">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the eukaryotic-type primase large subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF89862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_657864.1">
        <property type="nucleotide sequence ID" value="XM_652772.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BGS0"/>
    <dbReference type="FunCoup" id="Q5BGS0">
        <property type="interactions" value="897"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5BGS0"/>
    <dbReference type="GeneID" id="2876037"/>
    <dbReference type="KEGG" id="ani:ANIA_00260"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN0260"/>
    <dbReference type="eggNOG" id="KOG2267">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026253_1_0_1"/>
    <dbReference type="InParanoid" id="Q5BGS0"/>
    <dbReference type="OMA" id="RINYKPW"/>
    <dbReference type="OrthoDB" id="421393at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005658">
        <property type="term" value="C:alpha DNA polymerase:primase complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006269">
        <property type="term" value="P:DNA replication, synthesis of primer"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07322">
        <property type="entry name" value="PriL_PriS_Eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.930.80:FF:000003">
        <property type="entry name" value="DNA primase large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058560">
        <property type="entry name" value="DNA_primase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016558">
        <property type="entry name" value="DNA_primase_lsu_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007238">
        <property type="entry name" value="DNA_primase_lsu_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10537">
        <property type="entry name" value="DNA PRIMASE LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10537:SF3">
        <property type="entry name" value="DNA PRIMASE LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04104">
        <property type="entry name" value="DNA_primase_lrg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26466">
        <property type="entry name" value="DNA_primase_lrg_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009449">
        <property type="entry name" value="DNA_primase_large_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140914">
        <property type="entry name" value="PriB N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9 10" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4 9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 9 10" id="KW-0408">Iron</keyword>
    <keyword evidence="7 9 10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 9" id="KW-0639">Primosome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA primase large subunit C-terminal" evidence="11">
        <location>
            <begin position="301"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="390"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="407"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="448"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR009449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR009449-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CBF89862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="500" mass="58019" checksum="14BC8AAEFCF707D7" modified="2005-04-26" version="1">MIRQEFNRIDPKRRANLNYKKTQFATPTFKQQDYPYRLNFYDTPPTAEITLEQFEQWAIDRLKILAEIEACSYRNKTAAETTAHITPLLQKFLPLSANTSSPKGAADPRIKNERQKDHYSHFILRLAFSATEDLRRRFARAETMLFRFRFQADDSRERRAFIDSLNLDWESVGEDERRELSEYLVAATPGLRRSDEDTWYKVDWERVPELVERRSVFLSKGKAYVPEREQLSMIIAEFTARLERALELTSRALPRLDEDDRLSPILNHLSKNFGSAESVYTEGEGFVDGAPITAASIDPLSQHFPLCMRSLHMSLRKNNHLKHFGRLQYTLFLKGIGLSLEECILFWRQSFKGFTDEEFNSRYKYNVRHAYGDVGGDINRRGRGYPPYSCQKILSDTNPGAGQTHGCPYRHFSVDNLIGLLQSTGVNDKDLLRGVREDVEKTRYHIACNRVFEYTHKAEIKRAKEDGSAGEIELDTIVHPNTYFKRSYLLKQLGKTPRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="118" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BH22</accession>
    <accession>C8VQ53</accession>
    <name>Q5BH22_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable quinone oxidoreductase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">NADPH:quinone reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ANIA_00158</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF90074.1"/>
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    <dbReference type="RefSeq" id="XP_657762.1">
        <property type="nucleotide sequence ID" value="XM_652670.2"/>
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    <dbReference type="AlphaFoldDB" id="Q5BH22"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_026673_3_1_1"/>
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    <dbReference type="OMA" id="VDMSYSR"/>
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        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
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    <dbReference type="GO" id="GO:0035925">
        <property type="term" value="F:mRNA 3'-UTR AU-rich region binding"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0070402">
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    </dbReference>
    <dbReference type="GO" id="GO:0003960">
        <property type="term" value="F:quinone reductase (NADPH) activity"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="CDD" id="cd05286">
        <property type="entry name" value="QOR2"/>
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        <property type="entry name" value="Quinone oxidoreductase 1"/>
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        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
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        <property type="entry name" value="ADH-like_N"/>
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    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
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    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
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    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
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    <dbReference type="InterPro" id="IPR047618">
        <property type="entry name" value="QOR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002364">
        <property type="entry name" value="Quin_OxRdtase/zeta-crystal_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48106">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE PIG3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48106:SF13">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01162">
        <property type="entry name" value="QOR_ZETA_CRYSTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="5">
        <location>
            <begin position="16"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00043088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00070796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBF90074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="332" mass="36005" checksum="E62C464B44C35B35" modified="2005-04-26" version="1">MPPLSTMKAIVTEKTGGPEVLEVRTHHPVPTASEGQLLVKNQIIGINYIDTYFRTGLYPSSKPEILGREAVGEVVAVGPGANPYNFQIGDRVAWLSTGSYAEYTAVPQAFAVKVPEGISNEDVMGSFLSGLTVLTLAKETYPVQRGDWVLLHAAAGGAGFLMTQVLKSIGAIVIGTAGGPEKVELVKSLGADYVIDYRSEEGKDWVKKVKEITNGRGVDVVYDSVGKDTWEGSLEAVKRKGMIVWFGNASGPVPPLPLAKLSPKCVKVARPQLFGYIQAREEFEFYVNELFNMLKSGNLKVKIHKVYPLEQVAEAHSDLEGRKTTGKLLLKA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-01-10" modified="2026-01-28" version="124" xmlns="https://uniprot.org/uniprot">
    <accession>Q8TFN1</accession>
    <accession>C8V6J4</accession>
    <accession>Q5B6J1</accession>
    <name>NMT_EMENI</name>
    <protein>
        <recommendedName>
            <fullName>Glycylpeptide N-tetradecanoyltransferase</fullName>
            <ecNumber evidence="4">2.3.1.97</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Myristoyl-CoA:protein N-myristoyltransferase</fullName>
            <shortName>NMT</shortName>
        </alternativeName>
        <alternativeName>
            <fullName>Peptide N-myristoyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">swoF</name>
        <name type="synonym">nmt1</name>
        <name type="ORF">AN3839</name>
    </gene>
    <organism>
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Eukaryot. Cell" volume="1" first="241" last="248">
            <title>Aspergillus nidulans swoF encodes an N-myristoyl transferase.</title>
            <authorList>
                <person name="Shaw B.D."/>
                <person name="Momany C."/>
                <person name="Momany M."/>
            </authorList>
            <dbReference type="PubMed" id="12455958"/>
            <dbReference type="DOI" id="10.1128/EC.1.2.241-248.2002"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <scope>FUNCTION</scope>
        <scope>MUTAGENESIS OF ASP-370</scope>
        <scope>CATALYTIC ACTIVITY</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>N-terminal glycyl-[protein] + tetradecanoyl-CoA = N-tetradecanoylglycyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15521"/>
            <dbReference type="Rhea" id="RHEA-COMP:12666"/>
            <dbReference type="Rhea" id="RHEA-COMP:12667"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57385"/>
            <dbReference type="ChEBI" id="CHEBI:64723"/>
            <dbReference type="ChEBI" id="CHEBI:133050"/>
            <dbReference type="EC" id="2.3.1.97"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location>Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the NMT family.</text>
    </comment>
    <comment type="sequence caution" evidence="5">
        <conflict type="erroneous gene model prediction">
            <sequence resource="EMBL-CDS" id="AAL14203" version="1"/>
        </conflict>
    </comment>
    <comment type="sequence caution" evidence="5">
        <conflict type="erroneous gene model prediction">
            <sequence resource="EMBL-CDS" id="EAA59104" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EC" id="2.3.1.97" evidence="4"/>
    <dbReference type="EMBL" id="AY057437">
        <property type="protein sequence ID" value="AAL14203.1"/>
        <property type="status" value="ALT_SEQ"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AACD01000062">
        <property type="protein sequence ID" value="EAA59104.1"/>
        <property type="status" value="ALT_SEQ"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF75267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8TFN1"/>
    <dbReference type="SMR" id="Q8TFN1"/>
    <dbReference type="FunCoup" id="Q8TFN1">
        <property type="interactions" value="924"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q8TFN1"/>
    <dbReference type="EnsemblFungi" id="CBF75267">
        <property type="protein sequence ID" value="CBF75267"/>
        <property type="gene ID" value="ANIA_03839"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AN3839"/>
    <dbReference type="eggNOG" id="KOG2779">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022882_2_0_1"/>
    <dbReference type="InParanoid" id="Q8TFN1"/>
    <dbReference type="OMA" id="GWKRDWH"/>
    <dbReference type="OrthoDB" id="60315at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004379">
        <property type="term" value="F:glycylpeptide N-tetradecanoyltransferase activity"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018008">
        <property type="term" value="P:N-terminal peptidyl-glycine N-myristoylation"/>
        <property type="evidence" value="ECO:0000255"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072657">
        <property type="term" value="P:protein localization to membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.170:FF:000003">
        <property type="entry name" value="Glycylpeptide N-tetradecanoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000042">
        <property type="entry name" value="Glycylpeptide N-tetradecanoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000056">
        <property type="entry name" value="Glycylpeptide N-tetradecanoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000903">
        <property type="entry name" value="NMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022677">
        <property type="entry name" value="NMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022678">
        <property type="entry name" value="NMT_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022676">
        <property type="entry name" value="NMT_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11377:SF5">
        <property type="entry name" value="GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11377">
        <property type="entry name" value="N-MYRISTOYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01233">
        <property type="entry name" value="NMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02799">
        <property type="entry name" value="NMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015892">
        <property type="entry name" value="N-myristl_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00975">
        <property type="entry name" value="NMT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00976">
        <property type="entry name" value="NMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0012">Acyltransferase</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000064241" description="Glycylpeptide N-tetradecanoyltransferase">
        <location>
            <begin position="1"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; via carboxylate" evidence="1">
        <location>
            <position position="493"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="82"/>
            <end position="85"/>
        </location>
        <ligand>
            <name>tetradecanoyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57385"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="216"/>
            <end position="218"/>
        </location>
        <ligand>
            <name>tetradecanoyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57385"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="224"/>
            <end position="228"/>
        </location>
        <ligand>
            <name>tetradecanoyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57385"/>
        </ligand>
    </feature>
    <feature type="mutagenesis site" description="Causes a temperature sensitive growth defect." evidence="4">
        <original>D</original>
        <variation>Y</variation>
        <location>
            <position position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="P14743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="12455958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <sequence length="493" mass="56419" checksum="3EAFEA4EC8A66A32" modified="2011-11-16" version="2">MSDSKDSKGKAPQKPNDAEQTPGGKLTPQAAEALLENNPSLKNELGGLDKDKALEALRKMDISELLTGLSLTGKNKKDMAAFKFWQTQPVPRFDEAASNAAGGPIKMIDPEKVSKEPDALIEGFEWTTLDLTNEEELRELWDLLTYHYVEDDNAMFRFRYSKSFLHWALMSPGWRKEWHVGVRATKSRKLVASISGVPTQIRVRGQKIKVTEINFLCIHKKLRSKRLAPVLIKEITRRCYLNGIYQAIYTAGVVLPTPVSSCRYYHRPLDWLKLYEVGFSPLPRGSTKARQITKNHLPSHTSTPNLRPMEAKDVDAVHDLLERYLNQFDIHQAFTREEIDHWLVYKESPQKEQVIWSYVVEDPETHKITDFFSFYNLESTVIQHPKHDCVRAAYLYYYATETAFLDDQKALKNRLQMLMNDALILAKKAQFDVFNALTSHHNPLFLEQLKFGAGDGQLHFYLYNYRTAPIAGGVNEKNLPDENRMGGVGVVML</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-06-21" modified="2025-04-09" version="99" xmlns="https://uniprot.org/uniprot">
    <accession>Q9P905</accession>
    <accession>C8VBP6</accession>
    <accession>Q5AVX0</accession>
    <name>PALC_EMENI</name>
    <protein>
        <recommendedName>
            <fullName>pH-response regulator protein palC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">palC</name>
        <name type="ORF">AN7560</name>
    </gene>
    <organism>
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1999" name="Mol. Microbiol." volume="33" first="994" last="1003">
            <title>Ambient pH signal transduction in Aspergillus: completion of gene characterization.</title>
            <authorList>
                <person name="Negrete-Urtasun S."/>
                <person name="Reiter W."/>
                <person name="Diez E."/>
                <person name="Denison S.H."/>
                <person name="Tilburn J."/>
                <person name="Espeso E.A."/>
                <person name="Penalva M.A."/>
                <person name="Arst H.N. Jr."/>
            </authorList>
            <dbReference type="PubMed" id="10476033"/>
            <dbReference type="DOI" id="10.1046/j.1365-2958.1999.01540.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="1986" name="Mol. Gen. Genet." volume="203" first="346" last="353">
            <title>Regulation of gene expression by pH of the growth medium in Aspergillus nidulans.</title>
            <authorList>
                <person name="Caddick M.X."/>
                <person name="Brownlee A.G."/>
                <person name="Arst H.N. Jr."/>
            </authorList>
            <dbReference type="PubMed" id="3016485"/>
            <dbReference type="DOI" id="10.1007/BF00333978"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Required for the proteolytic cleavage of the transcription factor pacC in response to alkaline ambient pH.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the palC family.</text>
    </comment>
    <dbReference type="EMBL" id="AF152925">
        <property type="protein sequence ID" value="AAF70857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AACD01000129">
        <property type="protein sequence ID" value="EAA62140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF79630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_680829.1">
        <property type="nucleotide sequence ID" value="XM_675737.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9P905"/>
    <dbReference type="STRING" id="227321.Q9P905"/>
    <dbReference type="EnsemblFungi" id="CBF79630">
        <property type="protein sequence ID" value="CBF79630"/>
        <property type="gene ID" value="ANIA_07560"/>
    </dbReference>
    <dbReference type="KEGG" id="ani:ANIA_07560"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN7560"/>
    <dbReference type="eggNOG" id="ENOG502QWTM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023703_0_0_1"/>
    <dbReference type="InParanoid" id="Q9P905"/>
    <dbReference type="OMA" id="PNDKEWM"/>
    <dbReference type="OrthoDB" id="10266451at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000815">
        <property type="term" value="C:ESCRT III complex"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071467">
        <property type="term" value="P:cellular response to pH"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042318">
        <property type="term" value="P:penicillin biosynthetic process"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900198">
        <property type="term" value="P:positive regulation of penicillin biosynthetic process"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900376">
        <property type="term" value="P:regulation of secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="CDD" id="cd09245">
        <property type="entry name" value="BRO1_UmRIM23-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.280:FF:000005">
        <property type="entry name" value="pH-response regulator protein palC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.280">
        <property type="entry name" value="alix/aip1 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004328">
        <property type="entry name" value="BRO1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038499">
        <property type="entry name" value="BRO1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037505">
        <property type="entry name" value="pH-resp_palC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40463">
        <property type="entry name" value="PH-RESPONSE REGULATOR PROTEIN PALC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40463:SF1">
        <property type="entry name" value="PH-RESPONSE REGULATOR PROTEIN PALC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03097">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01041">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51180">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000218887" description="pH-response regulator protein palC">
        <location>
            <begin position="1"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="BRO1" evidence="1">
        <location>
            <begin position="1"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="375"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="439"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="375"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; AAF70857." evidence="4" ref="1">
        <original>EL</original>
        <variation>DV</variation>
        <location>
            <begin position="325"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="3016485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="507" mass="54608" checksum="6FFD5FF0237D2F3F" modified="2011-11-16" version="2">MVYPFELPTTSHLSFQSALSSHTHPSLPQSATTARHALRLALKAHNRLPRGFQRDSHLTSVLSAINDYLPYVVALAQGLNNGKPIDTTTPSTTTHLEEIRVAQRAELEPEWRATLASSSLRRPSTNRTRGTGVQYELAFILTTLGYILSSLARSGVTRTLYASTTPSAEQRTAAVQTATKHLLQASTIHSFLSSSPYFATVSEAATLPDLAPATQAALSSLALAEATLLTVLKDDSYVVACIQARNPNDKDWMVRAPEIPKVRAHLFARLCIRAAEYAEQAATGLSSVAAEGRKAGVDEDVARYAHVLGLVARARACRFFGVDAELAGKVGEGIAWLRAAKGALGLRNTGSASAEEVTTKSRGLSKLKLGFRERREERKLEKGAGGERVDKGGLGPGDNAGREEEGRVLEMLETKWVRANDTLNTQLIPSSADYVANLPSGRDVLPPQPPYTPPSLDEERLFQMRGPPTELELNPGSDDGDSDFESQAAGDAHTPGAFPGRADNAYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>C8UZY0</accession>
    <name>C8UZY0_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ANIA_10748</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF70659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467063.1">
        <property type="nucleotide sequence ID" value="XM_050612613.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8UZY0"/>
    <dbReference type="GeneID" id="74896579"/>
    <dbReference type="KEGG" id="ani:ANIA_10748"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN10748"/>
    <dbReference type="HOGENOM" id="CLU_2775914_0_0_1"/>
    <dbReference type="InParanoid" id="C8UZY0"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF70659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="69" mass="7591" checksum="BA7AEACDB7F44726" modified="2009-11-03" version="1">MFVLDGNLGVDGQWNDAKLGVAIPHSFRVRQPGQDVNTSQSGCFSSKGVSKMNGIVCMVHRCRPKEKDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>C8V2C5</accession>
    <name>C8V2C5_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VOC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_10787</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF70120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050466996.1">
        <property type="nucleotide sequence ID" value="XM_050611881.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V2C5"/>
    <dbReference type="GeneID" id="2871209"/>
    <dbReference type="KEGG" id="ani:ANIA_10787"/>
    <dbReference type="eggNOG" id="ENOG502RMEJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052361_0_1_1"/>
    <dbReference type="InParanoid" id="C8V2C5"/>
    <dbReference type="OMA" id="FEVNDFD"/>
    <dbReference type="OrthoDB" id="3360610at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.180.10:FF:000034">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.180.10:FF:000039">
        <property type="entry name" value="Trihydroxytoluene oxygenase (AFU_orthologue AFUA_8G02470)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051785">
        <property type="entry name" value="MMCE/EMCE_epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43048">
        <property type="entry name" value="METHYLMALONYL-COA EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43048:SF3">
        <property type="entry name" value="METHYLMALONYL-COA EPIMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="2">
        <location>
            <begin position="197"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF70120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="360" mass="40916" checksum="E2F257DFBDC3E685" modified="2009-11-03" version="1">MTPATKPIRLVRLAHVCYTHVDLAAASRFLIDFGFQELTQTVSPSTGQRTIYYRGTTTQQPFVYCAREGPEDAFGGAAFVVESREDFDYAAETLPGPAGIVDLEAEGVPGGGLSLTFHDPVDGFPFHLVWGQRGREEEGEKQGEDGLPVLQYNFPTEKHRPGNSSQRFKPGMSSLASPGINYCIQTNLRSGPAPVHKLGHFGMCVTDFARAYEFYTTRFNFKASDLIHDEAGKDVTAFLHLDRGRELVDHHCFFIFEGPKWHVHHSSFETHDFDTQLLGHHWLREKGYTNCWGVGRHIMGSQIFDYWFDPSRFILEHYVDGDLVDETYPTHRSLASPDNLHVWGGSFLFFHVRTRYWSWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>C8V3X4</accession>
    <name>C8V3X4_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex</fullName>
            <ecNumber evidence="6">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ANIA_03639</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="6"/>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF75718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467508.1">
        <property type="nucleotide sequence ID" value="XM_050611481.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V3X4"/>
    <dbReference type="STRING" id="227321.C8V3X4"/>
    <dbReference type="GeneID" id="2873063"/>
    <dbReference type="KEGG" id="ani:ANIA_03639"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN3639"/>
    <dbReference type="eggNOG" id="KOG0558">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016733_10_0_1"/>
    <dbReference type="InParanoid" id="C8V3X4"/>
    <dbReference type="OMA" id="MPFCIKA"/>
    <dbReference type="OrthoDB" id="15567at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160157">
        <property type="term" value="C:branched-chain alpha-ketoacid dehydrogenase complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045333">
        <property type="term" value="P:cellular respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06849">
        <property type="entry name" value="lipoyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000041">
        <property type="entry name" value="Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000007">
        <property type="entry name" value="Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.320.10:FF:000009">
        <property type="entry name" value="Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="entry name" value="E3-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050743">
        <property type="entry name" value="2-oxoacid_DH_E2_comp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004167">
        <property type="entry name" value="PSBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43178">
        <property type="entry name" value="DIHYDROLIPOAMIDE ACETYLTRANSFERASE COMPONENT OF PYRUVATE DEHYDROGENASE COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43178:SF5">
        <property type="entry name" value="LIPOAMIDE ACYLTRANSFERASE COMPONENT OF BRANCHED-CHAIN ALPHA-KETO ACID DEHYDROGENASE COMPLEX, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02817">
        <property type="entry name" value="E3_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47005">
        <property type="entry name" value="Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51826">
        <property type="entry name" value="PSBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4 6" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="8">
        <location>
            <begin position="50"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Peripheral subunit-binding (PSBD)" evidence="9">
        <location>
            <begin position="184"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="129"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="138"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="157"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBF75718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="471" mass="51190" checksum="B22CFA24397B9D98" modified="2009-11-03" version="1">MMNLLRCSRGFSKAWTSSQSRTALSVLRSSWPTIGPTTRSFHAALALGGIRSQVLKDVGEGITEVQIIQWYVEEGARVEEWKPLCQYQSDKAVDDITSRYEGIVKKLHFQADDTVPTGRALCDIEVDDAQYPEDHPPTESNAETSPPARTTIDSQPVPRPTTPLPASPAAEIPSNGAKGRYATLATPAVRGLLKQLNVNIEDVKGTGKDGRVLKEDIHRFVAMRDAPSATPSLSQDADTAVNLTHIQTQMFKTMTRSLTIPHFGYADELNINNITALRKKIANDKSDPRKITFLSFVVKAVSLALNDYPILNAKLDTSNADKPQLIMRPRHNIGIAMDTPQGLIVPNIKDVGSRSILDVAQEISRLSALGKEGKLTPADLSGGTITVSNIGNIGGTYVSPVLVPNELAILGIGRARTIPVFDDAGQVTKGEVVNFSWSADHRVVDGATMARMASKVKELIESPERMLLSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>C8V4D1</accession>
    <name>C8V4D1_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Aminotransferase class I/classII large domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ANIA_10529</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF74491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467334.1">
        <property type="nucleotide sequence ID" value="XM_050611293.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V4D1"/>
    <dbReference type="FunCoup" id="C8V4D1">
        <property type="interactions" value="402"/>
    </dbReference>
    <dbReference type="STRING" id="227321.C8V4D1"/>
    <dbReference type="GeneID" id="74896459"/>
    <dbReference type="KEGG" id="ani:ANIA_10529"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN10529"/>
    <dbReference type="eggNOG" id="KOG1357">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015846_7_2_1"/>
    <dbReference type="InParanoid" id="C8V4D1"/>
    <dbReference type="OMA" id="CVKIGIQ"/>
    <dbReference type="OrthoDB" id="65434at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017059">
        <property type="term" value="C:serine palmitoyltransferase complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004758">
        <property type="term" value="F:serine C-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046512">
        <property type="term" value="P:sphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd06454">
        <property type="entry name" value="KBL_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000004">
        <property type="entry name" value="2-amino-3-ketobutyrate coenzyme A ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050087">
        <property type="entry name" value="AON_synthase_class-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693:SF82">
        <property type="entry name" value="AMINOTRANSFERASE CLASS I_CLASSII DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693">
        <property type="entry name" value="CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="6">
        <location>
            <begin position="164"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBF74491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="580" mass="64674" checksum="CA4E11C668793BC7" modified="2009-11-03" version="1">MVSLRSVTRCFNDENTAGTTADLATGPAENLTKKHAEFGPLGDPSHLYTSVVFGGEIPDPVVDEPPYFIILTTYISFLVLIFLGHFQDFVSRWFQPHTYLRLRSQNGYASLYNGFESFFSRRMKQRINDCFERPTTGVPGRHVVLLDRISKDNIHFELTGKATDTLNLSSYNYLGFAQSEGPCADTVEETIYRDGISMAGPYPGTTKLLVEVEDQISRLVGKDAAIVFSIGFVTNSTVFQALVQRECLILSDEFNHASIRFGARLSGAAIEVFAHNNMTSLDEKLRQAISQGQPRTHRPWKKIMVTVEGLYSMEGTMCNLPQILELKKKYKFYLFIDEAHSIGAIGSRGRGVCDYFKVDPADVDILMGTFTKSFGATGGYVAANQPIIDKLRCTNAGQAYSEAPTLPVLAQISSSLRLIADEDPLYPGQGLERMQRLTFNSRYLRLGLKRLGFIVYGHDDSPIVPLMLYHPAKMPAFSREMLRRKISVVVVTYPATPLELSRARLCVSAAHTKDDLDRVLEACDEVGEALQLKFSSGKAGGLKQPRPCVTISPDKITEPPRWTLTEIIKWGVRDAKLTLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>C8V4I8</accession>
    <name>C8V4I8_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glucose oxidase goxC-Aspergillus niger [putative sequencing error] (ANG_orthologue An01g14740)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ANIA_07890</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF73465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467217.1">
        <property type="nucleotide sequence ID" value="XM_050611164.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V4I8"/>
    <dbReference type="STRING" id="227321.C8V4I8"/>
    <dbReference type="GeneID" id="2869220"/>
    <dbReference type="KEGG" id="ani:ANIA_07890"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN7890"/>
    <dbReference type="eggNOG" id="KOG1238">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091406_0_0_1"/>
    <dbReference type="InParanoid" id="C8V4I8"/>
    <dbReference type="OMA" id="YSGPRND"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF201">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE OXIDOREDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="6">
        <location>
            <begin position="106"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBF73465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="266" mass="29568" checksum="56F1944349FC5733" modified="2009-11-03" version="1">MVIDIQPSLLSNPHDVAGKIRLIIVGGGLTVFTAAAKLTEDPKVKVLIIEKGFYESSDGPIIEDPTKYSKIFRTSADQNFFTVPLINNRTELIKSEKGPGGSTLVFGMDGWNWDSLFQYMNKGERSRPPIEAQIATGHSFNSSCHGLNGTIHTGYRDTGEPWSPLMNALMTTVSEQGIHTQIDFHCDRPRGVSMIHNNVLENQVRADAAREWLLPNYQRPNLKILTGQVVGKVLFDEESKASSLTGECSAFDADIDQWAEYVTEYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C8V4N3</accession>
    <name>C8V4N3_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha/beta hydrolase, putative (AFU_orthologue AFUA_6G11570)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ANIA_10520</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF74547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467347.1">
        <property type="nucleotide sequence ID" value="XM_050611308.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V4N3"/>
    <dbReference type="STRING" id="227321.C8V4N3"/>
    <dbReference type="GeneID" id="74896452"/>
    <dbReference type="KEGG" id="ani:ANIA_10520"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN10520"/>
    <dbReference type="eggNOG" id="ENOG502QR0K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021595_0_0_1"/>
    <dbReference type="InParanoid" id="C8V4N3"/>
    <dbReference type="OMA" id="DWYNTEH"/>
    <dbReference type="OrthoDB" id="2851338at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43039">
        <property type="entry name" value="ESTERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="304"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="243"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBF74547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="545" mass="60596" checksum="0B68617F810D16E3" modified="2009-11-03" version="1">MATPGLLYVTMQPRPSLPAAQFHDWYNSEHGPLRLRLPFITNGFRYRAVDGVEPEWVALYDITDMDELTRETYLSLRGDTIKTPREKATMAQIDVGRKLYDLLQDEKASDFKPLEDQPDTAASGHVLISNTSTLPADKEDDLKAWYKEEHIPMLARVPGWRRSRLFVTASIDPKAQREFVALHEFTPQNGLGGPEHKASMETPWRARIADALTSKTRRVYNWAYTFGPAPRELGSLASPDTIGPWSSNDGRTRTLPDQTNPAVESYITTPDGVEIPYRLEGSTDPHSSVIVLSNSILVDYTIWDSFVKSFLAEERNRKFRILRYNTRGRSAAAGETPINVDVLAGDIIALLDALRIPQAILIGVSLGGVTVLNTSLLYPSRVKTFISCDTNSSAPETNRKAWNDRAAIAESEGATHPETKEPIIGEELSEVTVRRWFTEKSYETQPEVPAKVKDVVRANSLVGFKKAMQALCAYDVRERMQKASVKGLFVAGDSDGVLPKTMKQMAEDLKVEGGAELKIVPGAGHLPMVEQPEAFKAVVNDFLHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>C8V5J7</accession>
    <name>C8V5J7_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">sterol 22-desaturase</fullName>
            <ecNumber evidence="8">1.14.19.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ANIA_04042</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.19.41" evidence="8"/>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF74825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467375.1">
        <property type="nucleotide sequence ID" value="XM_050611339.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V5J7"/>
    <dbReference type="FunCoup" id="C8V5J7">
        <property type="interactions" value="1490"/>
    </dbReference>
    <dbReference type="STRING" id="227321.C8V5J7"/>
    <dbReference type="GeneID" id="2873461"/>
    <dbReference type="KEGG" id="ani:ANIA_04042"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN4042"/>
    <dbReference type="eggNOG" id="KOG0157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023517_0_0_1"/>
    <dbReference type="InParanoid" id="C8V5J7"/>
    <dbReference type="OMA" id="KCIGLEY"/>
    <dbReference type="OrthoDB" id="1372046at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000249">
        <property type="term" value="F:C-22 sterol desaturase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd11082">
        <property type="entry name" value="CYP61_CYP710"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000021">
        <property type="entry name" value="Cytochrome P450 61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24286:SF228">
        <property type="entry name" value="C-22 STEROL DESATURASE ERG5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24286">
        <property type="entry name" value="CYTOCHROME P450 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 10" id="KW-0349">Heme</keyword>
    <keyword evidence="7 9 10" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="477"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00039038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CBF74825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="531" mass="60281" checksum="07AC38380BDDFB62" modified="2009-11-03" version="1">MAEINGSFVSPAADATVFPQVFQPAGLIADFLNGLTLWKTLATLFALAVVYDQFRYIYLKGAIVGPAWKLPFMGPFLQSVNPKFHEYKAKWDSGELSCVSVFHKFVVIASTRDMSRKIFNSPTYVKPCVVDAAHKLLGKTNWVFLDGKEHVDFRKGLNNLFTRQALSCYLPRMEEVYNDYYARFLKKSKNNNYKPTPWMPEFRDLMCAVSCRTFVGHYISDEAIDKISVDYYNITAALELVNFPIILPFTKTWYGKKAADMVLDEFAKCAAKSRARMAAGGEISCIMDAWIKAQLDSAKYREKIAKGIEVDSSEKPPQVLRDFTDYEVSQTIFTFLFASQDATSSACTWLFQLMADRPEILDKVREENLRLRNGDVNAPLTMDLLDSMTYTRAVVKETLRYRPPVIMVPYIAKKDFPITDKITVAKGSMIIPSVYPATRDEEAYPNADSFDPDRWITGTAEQHPKNFLIFGTGPHYCLGQTYAVLNLMAMIGKASMEMDWVHTPTPQSEEIKVFATIFPQDDCLLTFRPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>C8V783</accession>
    <name>C8V783_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ANIA_11057</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF74131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467281.1">
        <property type="nucleotide sequence ID" value="XM_050611234.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V783"/>
    <dbReference type="GeneID" id="74896756"/>
    <dbReference type="KEGG" id="ani:ANIA_11057"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN11057"/>
    <dbReference type="HOGENOM" id="CLU_1815760_0_0_1"/>
    <dbReference type="InParanoid" id="C8V783"/>
    <dbReference type="OrthoDB" id="292213at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052241">
        <property type="entry name" value="SLC66/Scramblase_ANY1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14856:SF9">
        <property type="entry name" value="PQ-LOOP REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14856">
        <property type="entry name" value="PQ-LOOP REPEAT-CONTAINING PROTEIN 1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBF74131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="142" mass="15671" checksum="BF1369234E371BB6" modified="2009-11-03" version="1">MYIVSQLLEYGAPIFIVTSPVTSYADQILSIHRNRSSAGFSLDIPLIMLVASILKVFFWVRRLLLSRSPGAGHLDDWSPSHTAKSCPGQSTGARAKKRNRAYSILVVPGLFHRCPFLHPHLPDAHLELPHLHQLPGILGTGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>C8V8T2</accession>
    <name>C8V8T2_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_04410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF77584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
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            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
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    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
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            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
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        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
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    </dbReference>
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        <location>
            <begin position="1"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CBF76455.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2025-10-08" version="75" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="9">Zn(II)2Cys6 transcription factor (Eurofung)</fullName>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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    <reference evidence="10" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
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            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
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            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
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    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_676832.2"/>
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    <dbReference type="AlphaFoldDB" id="C8VAB2"/>
    <dbReference type="STRING" id="227321.C8VAB2"/>
    <dbReference type="GeneID" id="2868570"/>
    <dbReference type="KEGG" id="ani:ANIA_08655"/>
    <dbReference type="eggNOG" id="ENOG502RMHE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015161_2_0_1"/>
    <dbReference type="InParanoid" id="C8VAB2"/>
    <dbReference type="OMA" id="TYVSDCA"/>
    <dbReference type="OrthoDB" id="426882at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
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    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF6">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="18"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="219"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="636"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="224"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="649"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="662"/>
            <end position="674"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBF78244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="726" mass="81631" checksum="EB7564D648908285" modified="2009-11-03" version="1">MMPPEGSGTRRRLRSNHACINCRRKKTRCPGEKPACSCCVRLNQQCSYAAVGGSSGPDKDRLAELEEKVNQILRGAAQHEQPTIEEAPDFASTTHGDVGYMQDNAYPSIFGLDGASPQASSLAVAKAIDLYLECCHRQPVWCLNIKELGNIESHPEELICSILALTSRFTRDAAQGQRYADSAKSLIMLRIANGTVELATIESLCLLAYSAFIGRKKKRKREGKKTGEEEKKEKETRLTGQTDGNLQLGRFHLGMGFQLCRAAMLDTEAAYMNQQDRHAEQKKRLFWSLQLLEQSYGRQTGLLSIPTSKWRPPYLSSCDPRASDNDSMPRPPPIPRDTVGCASPDDTGIWSMSIHFGWVWSKVRAYVSHCSSNRVTEPWRHESMYAVVLSDLNEIENSTPLCHRYDHVQFYRRTAEELAVNKSYWVPWVKLQFMYHAILTVLNHPFLYIMASQHNPNLAIPNSFWRRSSELVLLHATWIVRLIDMVSEKNVRLTDPFFAHVAGIAATVQLYYCCADDPRLKYKSRADFAKCSDFLRGFTGFSRACEVLSQKLDALTRIASGTEIIDLDDWVPSKIHLNIPLMWDILQFNVSTDFETEGRGLLHPSLAPTTMTPSPNDISNLDIIVTASPEVSVNTADGGQAVPMPLYRSPTTATAESLRNTSLRDRDRDRERDPLVAPVDSLMLNTPWLWADSSQFSGNMDEVEYHDSMPVVGDVEGSAWWNLGNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>C8VAX8</accession>
    <name>C8VAX8_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF8035 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_04698</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF76973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467660.1">
        <property type="nucleotide sequence ID" value="XM_050611656.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VAX8"/>
    <dbReference type="STRING" id="227321.C8VAX8"/>
    <dbReference type="GeneID" id="2872498"/>
    <dbReference type="KEGG" id="ani:ANIA_04698"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN4698"/>
    <dbReference type="eggNOG" id="ENOG502SM5I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018248_0_0_1"/>
    <dbReference type="InParanoid" id="C8VAX8"/>
    <dbReference type="OMA" id="MIDPMRA"/>
    <dbReference type="OrthoDB" id="5418088at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058348">
        <property type="entry name" value="DUF8035"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42081">
        <property type="entry name" value="ZINC FINGER PROTEIN DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42081:SF1">
        <property type="entry name" value="ZINC FINGER PROTEIN DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26118">
        <property type="entry name" value="DUF8035"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF8035" evidence="2">
        <location>
            <begin position="509"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="563"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="414"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="441"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="452"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="478"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="563"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="588"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF76973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="615" mass="70211" checksum="9677EE3EAE9710A7" modified="2009-11-03" version="1">MSSAARYRPISPGSANMIDPLRASTGTVQLASSYDPYDPAGRPIYTGYRSDVPYSPTYDSRYPVAPRLEAHPVSQQTYHDPGQSTRLRTEYAIRPRQRSSTTSAADSHGRLGVPPISSVSRTSAVVLSDYGRSPSPLTDQDGYLVPASSRHHRHHRHSSYDYASDTGGQPTSRRHYGAYPTYVSRRRYPQNGGLRKGEDIDKYDAYSYTNPREQFEKEAVAKLQYHRNARKERPLSLTGIEDPRLLGRRDPRAHGPPPSHRGYDKVHRDDLRRSTYGFGNSELDLASARQRPPRSVTLHQDHDEGYSSYRDEFDDTRPAHREHKRPDGDARKRDTIDSHGARKPFNKQSPPSVSGSGLGTAVLASGYSEGQDYDLSSHADRYRHRGRVPRDRSRSRRRSRRRGGSESDECSSDDDLKKYRREPSVRPRINGSDSSKENEPHRHRSRSRHHERPSDKKSDQKKTDSKEPDAPPKGILKPPRDKFPEEPNPVREGVAPLKDAHKKGIPPGARWTKIDRRLVNPAALEAGQERFEERPDHVIVLRVLTKEEIQAYAVKTQEIRDSRYREYIRERRRQREEDRRRGRPVDDFSSDDEDESDNFPLAIEGPGEPRSSQKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>C8VC27</accession>
    <name>C8VC27_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_10995</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF79869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468016.1">
        <property type="nucleotide sequence ID" value="XM_050612057.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VC27"/>
    <dbReference type="GeneID" id="74896721"/>
    <dbReference type="KEGG" id="ani:ANIA_10995"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN10995"/>
    <dbReference type="HOGENOM" id="CLU_2223259_0_0_1"/>
    <dbReference type="InParanoid" id="C8VC27"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF79869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="106" mass="11608" checksum="D8331FFAA7843CAE" modified="2009-11-03" version="1">MQGSCFTLHTCRCRSIEDTVHLTPLHQIATCYELPEHSRSQSLFWCIMAMPSIVVCSGGHSATLADDQTTTGTRAPLRASAHDHSSSAKAYRIRVAEDRCVRSCAA</sequence>
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<entry dataset="TrEMBL" created="2009-11-03" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>C8VDS5</accession>
    <name>C8VDS5_EMENI</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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    <gene>
        <name evidence="1" type="ORF">ANIA_11012</name>
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    <organism evidence="1 2">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF80140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_681072.2">
        <property type="nucleotide sequence ID" value="XM_675980.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VDS5"/>
    <dbReference type="GeneID" id="2869436"/>
    <dbReference type="KEGG" id="ani:ANIA_11012"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN11012"/>
    <dbReference type="eggNOG" id="ENOG502SI4B">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027146_1_0_1"/>
    <dbReference type="InParanoid" id="C8VDS5"/>
    <dbReference type="OMA" id="KEIECIM"/>
    <dbReference type="OrthoDB" id="4360026at2759"/>
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        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF80140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="370" mass="42561" checksum="38813802CFFCA743" modified="2009-11-03" version="1">MKTTTKRIVLRGLLPILTRALNARDIMSNKIPDISDPDEFPYCIWYPETATEVTYRALAGRYPQVKYLIGRACAVAGYVGLFHELDLLPQFHIAEEARENQQWEINDTIMKADIRFNAMNDYTLTVFSQPIKGCLNGDTAVRAYLDIKTKFKAPPDLDDLLYDGGRRTSHFDITEDDPINARFIMNNDLSRITPETKHLPYCIWYTSVPHPSTCKELFRRVPSMKPAIARACILANFPETWDLLDADPDENSMMDARQSHNPKYLRDLESKIPTRGCRQFHGSKFRVVPRHCMFDYTSIDPTTNVSHNPCTDYLVGVPYNGRPASMAQIELTAALPHEMKKLIKELWERDYTTLTFDDEYYASLRNKGSQ</sequence>
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<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>C8VH01</accession>
    <name>C8VH01_EMENI</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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    </protein>
    <gene>
        <name evidence="1" type="ORF">ANIA_11474</name>
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    <organism evidence="1 2">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
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            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF82178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468296.1">
        <property type="nucleotide sequence ID" value="XM_050612365.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VH01"/>
    <dbReference type="GeneID" id="74897051"/>
    <dbReference type="KEGG" id="ani:ANIA_11474"/>
    <dbReference type="HOGENOM" id="CLU_2904180_0_0_1"/>
    <dbReference type="InParanoid" id="C8VH01"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF82178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="62" mass="6776" checksum="76E8D8AC8AC38488" modified="2009-11-03" version="1">MADVKAHFLINQAGVRALHRQVLARDITDAAVGGSRDRADSRVWGCDGVEIWERTGSIPRAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>C8VHH7</accession>
    <name>C8VHH7_EMENI</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ANIA_11356</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF84328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468578.1">
        <property type="nucleotide sequence ID" value="XM_050612687.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VHH7"/>
    <dbReference type="GeneID" id="74896956"/>
    <dbReference type="KEGG" id="ani:ANIA_11356"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN11356"/>
    <dbReference type="eggNOG" id="ENOG502RPJF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2346670_0_0_1"/>
    <dbReference type="InParanoid" id="C8VHH7"/>
    <dbReference type="OrthoDB" id="4509242at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF84328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="97" mass="10788" checksum="828B7CE7393850DE" modified="2009-11-03" version="1">MTYKGLFSEQDAHQPVAIKDKHEAVQQQIISNLQAQSKSDLSAALPSLPRKKDGTVYISNMRKKIKELGYIIPCNKYPSAKDCCKDQNTSLRPAAVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>C8VJ14</accession>
    <name>C8VJ14_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MGS207 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_10370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF83662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468487.1">
        <property type="nucleotide sequence ID" value="XM_050612578.1"/>
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    <dbReference type="AlphaFoldDB" id="C8VJ14"/>
    <dbReference type="STRING" id="227321.C8VJ14"/>
    <dbReference type="GeneID" id="74896365"/>
    <dbReference type="KEGG" id="ani:ANIA_10370"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN10370"/>
    <dbReference type="eggNOG" id="ENOG502QSSH">
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    <dbReference type="InParanoid" id="C8VJ14"/>
    <dbReference type="OMA" id="NHWNAWK"/>
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    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
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    <dbReference type="GO" id="GO:0016491">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025337">
        <property type="entry name" value="Questin_oxidase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35870:SF6">
        <property type="entry name" value="MGS207 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35870">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G03330)-RELATED"/>
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    <dbReference type="Pfam" id="PF14027">
        <property type="entry name" value="Questin_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF83662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="411" mass="47281" checksum="66C9EF672A6D5D19" modified="2009-11-03" version="1">MPLNFLKNLLPWGERVIFNLPPCQIVEIDTAQEKAARALKHLLKLNHANYAILWNERKFHNHAPHSLCSFYLLGANADDLNRLYEAELKPLEAWIDSPGEISTYDWRDYLGKREYQRAYVDFFEDELVRHGYDWKTVVFQYLFSGKEPLFNALASDLGHPLIHLAYAFEVSSREVAMEALSLATVCYGTAHKYLDDPSYSQAESSYHSTSPFEILQKVRADKRLSNLFTAPGDHNTEIVFRDAEATILDHWNAWKITSNSDPVKSFRESQELAVALLTATSSSDNRDAKYDFFFVHVLTTSHAVRVLLPLIPAKFQIPLVRQWWLMTLAVYIGQLRPEINLHSVRKYDTEGKGWGYMKDKALHGEHSTETHYIKALRVIRDIARTWGDPDEFYLKAALKFADGFTGWGGFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>C8VJG5</accession>
    <name>C8VJG5_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ANIA_10358</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF83931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468527.1">
        <property type="nucleotide sequence ID" value="XM_050612626.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VJG5"/>
    <dbReference type="STRING" id="227321.C8VJG5"/>
    <dbReference type="GeneID" id="2874516"/>
    <dbReference type="KEGG" id="ani:ANIA_10358"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN10358"/>
    <dbReference type="eggNOG" id="KOG0023">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_20_1_1"/>
    <dbReference type="InParanoid" id="C8VJG5"/>
    <dbReference type="OMA" id="PTWDTCM"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08297">
        <property type="entry name" value="CAD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000039">
        <property type="entry name" value="Alcohol dehydrogenase AdhP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940:SF1">
        <property type="entry name" value="ENOYL REDUCTASE (ER) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="10">
        <location>
            <begin position="22"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CBF83931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="361" mass="38156" checksum="8C4A63BC63657353" modified="2009-11-03" version="1">MGSITPLEIPTHCKAGVIYNPGPNFTVKVEDVPVPQPGADDILIRLNVTGLCQSDLHYMLDDLGISMSTFGVRSPGHEGAGVVVKVGENVKNFKVGDRAGIKPMMDTCGACTSCWSDKETYCAGAVHTGLMVPGTYQQYVVSPARYATPIPEGIPDEIAAPIMCSASTIYRSLVESRLQAGDWAVFPGGGGGVGIQGVQLASAMGMRPIVVDTGEEKKNLALKMGAEAFIDFKTVPDAAAAVVEIADGIGGHGVFVTAQAAYPTALAYLGTRIGGDLMCIGIAPAGTMSIPVDPNLLLFRNTRIQGTLVGSRHDTIKALDFARRGKLKQICEVWPVERLPEAVDRLRKGLVAGRMVVDFNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>C8VL02</accession>
    <name>C8VL02_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ANIA_11639</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF84488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468591.1">
        <property type="nucleotide sequence ID" value="XM_050612702.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VL02"/>
    <dbReference type="GeneID" id="74897192"/>
    <dbReference type="KEGG" id="ani:ANIA_11639"/>
    <dbReference type="HOGENOM" id="CLU_3143046_0_0_1"/>
    <dbReference type="InParanoid" id="C8VL02"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF84488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="49" mass="5746" checksum="A088A7890D6513D9" modified="2009-11-03" version="1">MPEYHPFDRVGSEKDPFTFILSTFSLPYHSRDLIALCKEDLTCKKLELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>C8VLW6</accession>
    <name>C8VLW6_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">KH domain RNA binding protein (AFU_orthologue AFUA_2G04940)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ANIA_10257</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF86155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468804.1">
        <property type="nucleotide sequence ID" value="XM_050612955.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VLW6"/>
    <dbReference type="FunCoup" id="C8VLW6">
        <property type="interactions" value="755"/>
    </dbReference>
    <dbReference type="STRING" id="227321.C8VLW6"/>
    <dbReference type="GeneID" id="74896300"/>
    <dbReference type="KEGG" id="ani:ANIA_10257"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN10257"/>
    <dbReference type="eggNOG" id="KOG2190">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022670_4_0_1"/>
    <dbReference type="InParanoid" id="C8VLW6"/>
    <dbReference type="OMA" id="MQVVPYS"/>
    <dbReference type="OrthoDB" id="1937934at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051252">
        <property type="term" value="P:regulation of RNA metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd22439">
        <property type="entry name" value="KH-I_PCBP_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22455">
        <property type="entry name" value="KH-I_Rnc1_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22456">
        <property type="entry name" value="KH-I_Rnc1_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10288">
        <property type="entry name" value="KH DOMAIN CONTAINING RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="106"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="189"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="389"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="334"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="28"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBF86155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="465" mass="48498" checksum="1CEDB0B482A8C7E7" modified="2009-11-03" version="1">MSASPSALQSTKRPLEDPSSPSGPNDQPEAKRPALDKVVKGEESENNAEVKTESGAANDADGQGDTVVPDAPKGGVSETQPIQSTASHGEAAGNQSEQQRPQDESNWIHIRAVISSQEAATVIGKGGENVSQIRRLSGAKCTVSDYSRGAVERILTVSGPQDAVAKAFGLIIRTLNNEPLDAASTAQSKTYPLRLLIPHILIGSIIGKGGTRIREIQDASGARLNASDACLPLSTERSLVILGVADAVHIATYYVAVTLVEQLTERFGGPAASAYATRSGGPAGAVPGGMQVVPYVPQPAGGQYGHPDTFKRHHPGQARAGAGAYGVPYLHGQHAPAPVAPQPMHYGAPQTPYAGAGPHQPTPYGAPQAAQPRGGPTPAAPVGGAMPGQPLTQQIYIPNDMVGAIIGKGGAKINEIRHLSGSVIKINEPQENSNERLVTITGTQECNQMALYMLYSRLESEKHRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C8VM99</accession>
    <name>C8VM99_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">TAM domain methyltransferase, putative (AFU_orthologue AFUA_2G15860)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ANIA_02165</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF86301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_659769.2">
        <property type="nucleotide sequence ID" value="XM_654677.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VM99"/>
    <dbReference type="GeneID" id="2874864"/>
    <dbReference type="KEGG" id="ani:ANIA_02165"/>
    <dbReference type="eggNOG" id="ENOG502S6PS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010595_1_2_1"/>
    <dbReference type="InParanoid" id="C8VM99"/>
    <dbReference type="OMA" id="RYHAYRN"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF10">
        <property type="entry name" value="ABC TRANSMEMBRANE TYPE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF86301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="373" mass="41912" checksum="96EE275EFD2CE088" modified="2009-11-03" version="1">MPPPNFHEQIQVDVSSLQVTSSRGQATIQRICLSPKAAGDLPYPSPPAGARELTVLQTSDEDSLYDADSVADSSLSFASTVRDYYYENGRRYHAYRYGQYPIPNDEEEQDRLNITHHLFKLLTGGDLYRTPLAQQPAPKRILDIGTGTGAWALEMAEQFPEAEIIGTDLSPIQPSFSPPNCTFIIDDAESDWAFSKDEPFDYIHARSMGGGIADWDRLFRQAYNHLKPGGWLEVQEFEAAIHSDDGTEEKAPMLVDLSKKLDEASKKFGKRVSVAPSLAGWMDRAGFTNITEDIYKCPVGSWPKSPRLKEIGRVGKVAVIEAIEPYSLALFTRVLGWSYERAQDYVNKCRREAMNCSGHIHILYYFVYAQRPL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2020-10-07" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>C8VN91</accession>
    <accession>Q5BCY2</accession>
    <name>PBCG_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cytochrome P450 monooxygenase AN1598</fullName>
            <ecNumber evidence="8">1.-.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Pimaradiene biosynthesis cluster protein AN1598</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="ORF">AN1598</name>
        <name type="ORF">ANIA_01598</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2012" name="PLoS ONE" volume="7" first="e35450" last="e35450">
            <title>Identification and characterization of a novel diterpene gene cluster in Aspergillus nidulans.</title>
            <authorList>
                <person name="Bromann K."/>
                <person name="Toivari M."/>
                <person name="Viljanen K."/>
                <person name="Vuoristo A."/>
                <person name="Ruohonen L."/>
                <person name="Nakari-Setaelae T."/>
            </authorList>
            <dbReference type="PubMed" id="22506079"/>
            <dbReference type="DOI" id="10.1371/journal.pone.0035450"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INDUCTION</scope>
        <scope>PATHWAY</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2016" name="Appl. Microbiol. Biotechnol." volume="100" first="6345" last="6359">
            <title>Engineering Aspergillus nidulans for heterologous ent-kaurene and gamma-terpinene production.</title>
            <authorList>
                <person name="Bromann K."/>
                <person name="Toivari M."/>
                <person name="Viljanen K."/>
                <person name="Ruohonen L."/>
                <person name="Nakari-Setaelae T."/>
            </authorList>
            <dbReference type="PubMed" id="27098256"/>
            <dbReference type="DOI" id="10.1007/s00253-016-7517-5"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INDUCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="4 5 8">Bifunctional terpene synthase; part of the gene cluster that mediates the biosynthesis of the diterpene ent-pimara-8(14),15-diene (PD) (PubMed:22506079, PubMed:27098256). Within the cluster, the HMG-CoA reductase AN1593 functions in the mevalonate pathway, which produces isoprenoid precursors (PubMed:22506079, PubMed:27098256). The geranylgeranyl pyrophosphate (GGPP) synthase AN1592 is needed in the formation of GGPP, the precursor for diterpenes (PubMed:22506079, PubMed:27098256). Lastly, the pimaradiene synthase pbcA performs the 2 cyclization steps that convert GGPP to ent-pimara-8(14),15-diene (PubMed:22506079, PubMed:27098256). The putative roles of the remaining cluster enzymes in ent-pimara-8(14),15-diene biosynthesis is unclear (Probable). The cytochrome P450 monooxygenase AN1598, the glutathione S-transferase AN1595, the oxidoreductases AN1596 and AN1597 probably function as decorative enzymes (Probable). It is possible that in biological conditions the compound is oxidized to ent-pimara-8(14),15-dien-19-oic acid, which is a bioactive diterpene compound predominant in many plant extracts.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Secondary metabolite biosynthesis; terpenoid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="4 5">Expression is positively regulated by the cluster-specific transcription factor pbcR.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="sequence caution" evidence="7">
        <conflict type="erroneous gene model prediction">
            <sequence resource="EMBL-CDS" id="EAA64305" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="8"/>
    <dbReference type="EMBL" id="AACD01000025">
        <property type="protein sequence ID" value="EAA64305.1"/>
        <property type="status" value="ALT_SEQ"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF85188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VN91"/>
    <dbReference type="EnsemblFungi" id="CBF85188">
        <property type="protein sequence ID" value="CBF85188"/>
        <property type="gene ID" value="ANIA_01598"/>
    </dbReference>
    <dbReference type="GeneID" id="2875700"/>
    <dbReference type="KEGG" id="ani:ANIA_01598"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN1598"/>
    <dbReference type="eggNOG" id="KOG0156">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022195_0_1_1"/>
    <dbReference type="InParanoid" id="C8VN91"/>
    <dbReference type="OMA" id="CKDEWVE"/>
    <dbReference type="OrthoDB" id="1844152at2759"/>
    <dbReference type="UniPathway" id="UPA00213"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0000270"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd11041">
        <property type="entry name" value="CYP503A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000059">
        <property type="entry name" value="Cytochrome P450 monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206:SF6">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE AN1598-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0349">Heme</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0503">Monooxygenase</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000450845" description="Cytochrome P450 monooxygenase AN1598">
        <location>
            <begin position="1"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="1">
        <location>
            <position position="464"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="3"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P04798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="22506079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="27098256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="6">
        <source>
            <dbReference type="PubMed" id="22506079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="7"/>
    <evidence type="ECO:0000305" key="8">
        <source>
            <dbReference type="PubMed" id="22506079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBF85188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="534" mass="61207" checksum="06921449276122F0" modified="2009-11-03" version="1">MDNYTWHSGTLIPSDSPSSIDRSQLYLEILGVLSVVYLLQTLVAYSKSFKAPFVGFRFWYEPKWLVGLRFSQGALAQVNEGYAKYKNAMFKVARNDSDILVIPNKYVEELRSLPDEKISAIRAHIKNLLGKYSTTLILLESDLHTRMLQTKLTPNLGSFIEVIESELLFAMDQEIPANLDDWQSVNVFHIVLRIVARISARVFLGVPACRNEEWLQTSIHYTENVFATVMLLRRFPKWMHPIVGHLLPSYWAIHRNLRTAKRIISPMVRQRRAEEAKRNPDYVKPNDLLQWMMDGANENDGQPDKLAHRQLLLSLASIHTTTMAAAHCFYDLCQHPEYFEPLREEINDVIAQDGGWKKTTLNKMRKLDSFLKESQRINPPSLLAFNRIVSEDLTLSDGTLLPKGTHFSMPSAAILQDNGVEPGADQFDGFRYYKKRLNPEEANKHQFAMTDNNNLHFGHGKYSCPGRFFASNEIKIIMAHLLTDYEFKYPRGATRPRNLTADENLYPDPSARLLMRRRVVAPPQASITPQLVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>C8VP28</accession>
    <name>C8VP28_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">NADH-ubiquinone oxidoreductase 30.4 kDa subunit, mitochondrial [Precursor] (Eurofung)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ANIA_10229</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29091"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="7.1.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the complex I 30 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF85447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468721.1">
        <property type="nucleotide sequence ID" value="XM_050612851.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VP28"/>
    <dbReference type="STRING" id="227321.C8VP28"/>
    <dbReference type="GeneID" id="2875435"/>
    <dbReference type="KEGG" id="ani:ANIA_10229"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN10229"/>
    <dbReference type="eggNOG" id="KOG1713">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042628_0_0_1"/>
    <dbReference type="InParanoid" id="C8VP28"/>
    <dbReference type="OMA" id="PCRKNRF"/>
    <dbReference type="OrthoDB" id="37721at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.80:FF:000002">
        <property type="entry name" value="NADH dehydrogenase iron-sulfur protein 3, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.80">
        <property type="entry name" value="NADH:ubiquinone oxidoreductase, 30kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01357">
        <property type="entry name" value="NDH1_NuoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010218">
        <property type="entry name" value="NADH_DH_suC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037232">
        <property type="entry name" value="NADH_quin_OxRdtase_su_C/D-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001268">
        <property type="entry name" value="NADH_UbQ_OxRdtase_30kDa_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020396">
        <property type="entry name" value="NADH_UbQ_OxRdtase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01961">
        <property type="entry name" value="NuoC_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004733">
        <property type="entry name" value="PRK06074.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10884:SF14">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10884">
        <property type="entry name" value="NADH DEHYDROGENASE UBIQUINONE IRON-SULFUR PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00329">
        <property type="entry name" value="Complex1_30kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143243">
        <property type="entry name" value="Nqo5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00542">
        <property type="entry name" value="COMPLEX1_30K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0520">NAD</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="NADH:ubiquinone oxidoreductase 30kDa subunit" evidence="10">
        <location>
            <begin position="106"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="27"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="257"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="32"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CBF85447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="290" mass="32783" checksum="CB4A5A2D0A8F4547" modified="2009-11-03" version="1">MAAPRSLMRLGSGRSLASAARSSRNCRAFSSTPLQQVAKATTAGTDTPNMRHAARPPPGPLRAPVVNPADKYQDKADSLHQYGQYIMACLPKHVQQFSVWKDELCIYVPPSGIIPTFTFLKYHTSAEFTTVSDITAVDYPTKDQRFEVVYNLLSVRYNSRIRVKTYADEASPVPSITGLYEGALWYEREVYDLFGVFFTGHPDLRRIMTDYGFDGHPLRKDFPMTGYTELRYDEEKKRIVIEPLELTQAFRNFEGGTTAWEPVGAGRDRTPESFKLASPKPEPPKEEEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>C8VPZ2</accession>
    <name>C8VPZ2_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Flavoprotein oxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_10133</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF88607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050469112.1">
        <property type="nucleotide sequence ID" value="XM_050613284.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VPZ2"/>
    <dbReference type="STRING" id="227321.C8VPZ2"/>
    <dbReference type="GeneID" id="74896222"/>
    <dbReference type="KEGG" id="ani:ANIA_10133"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN10133"/>
    <dbReference type="eggNOG" id="ENOG502SAW3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_341955_0_0_1"/>
    <dbReference type="InParanoid" id="C8VPZ2"/>
    <dbReference type="OMA" id="QDCGYNS"/>
    <dbReference type="OrthoDB" id="5369448at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="448"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="613"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="656"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="772"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="93"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="458"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="676"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="772"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="805"/>
            <end position="814"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF88607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="829" mass="91339" checksum="2C659C2B1EAA1511" modified="2009-11-03" version="1">METSVDSQTIHLKEKANPSMSDHEATTISAAISDPANSEKQSEHSDESSFDRSMQVAAQDSGYNSSGSSGHHSPVGTQNGGPEEGELVRIRSRTSSCTSISSIPASTLTSPAGENRRMNIREGQDYMAQPWDHHVPQLRHTIRQREGTFRKPSSVRALQMHTEDEGDDYYHLTPPKRRGSQRTSDISIRSAGSSPFKRSPFYSPTGATAKPKIKKEYPLVLLHCTLLPPSLPVSGLIEHPNRQNILKEGLPSVYWRRWKLLEEKTGSGVIRDRGILISHPEDGYDLLEERLLESLELQHPRLDHGHFIGHDETESDGEDRLVPEDSGTEDEGEECPDCGARVVRQNTTRKWEVKVFAANGLMRAGAWAAAWKEMEKVDVEVGLWLPPDIRADLEKRLIEYPSHMNIANGPPIALLQEPENIPVDPSVRALTTKPPKADMLSQVTQARGGDLAPASPGVTASRSQDNQKWTQNTPKLSEDIDLRLLLVNYIYILASDRRNITIVFLSILVIFFALNPRAAVYESDLRPFPTYIPEYTTSPVVSLQQPATQTWTVHTSSQTPSVAISDPAGILASAVESVPFVSSDDIPTAAAGLSVTKREEVPPTETVTVSAKSAKIVSEEQEEPIPSIELGRESPLGAESCDLFAEGTRLVSKLREQSVYPRGNEPDGPVQIETDSSSMGSAESGSGEQEQFPHSSESALEKPQPTDTGDSPMKNTEAVPEEQRCLAQLSESVLEESLLTAVESPSIDDIHHTPEERPLQFMETVSMTESLSTAASINHSDADQTLPTDDQHNENEQNGQNGQNEPHELHELHEPVLPNEHDDDEMHEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>C8VRF7</accession>
    <name>C8VRF7_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Steroid monooxygenase, putative (AFU_orthologue AFUA_8G00440)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ANIA_00027</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF90348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050469360.1">
        <property type="nucleotide sequence ID" value="XM_050611096.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VRF7"/>
    <dbReference type="GeneID" id="2875803"/>
    <dbReference type="KEGG" id="ani:ANIA_00027"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN0027"/>
    <dbReference type="eggNOG" id="KOG1399">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006937_8_1_1"/>
    <dbReference type="InParanoid" id="C8VRF7"/>
    <dbReference type="OMA" id="NYFQTFN"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050775">
        <property type="entry name" value="FAD-binding_Monooxygenases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43098:SF5">
        <property type="entry name" value="DUAL-FUNCTIONAL MONOOXYGENASE_METHYLTRANSFERASE PSOF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43098">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBF90348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="544" mass="61769" checksum="5D820732127F69DD" modified="2009-11-03" version="1">MGSIGHPPLEQNGFLDYDVLIIGAGLSGIYSLHQMRALGLRVKVLEAGGGPGGTWYWNRYPGARFDSESYSYGFSWSQEVLDEWSWSEHFAGQSETLRYCEFLVSKFDLARDMQFNTRVKQAHYQEDSRSWLLTDDKGNTYSSRWLVTCMGILNQYTLPNIPGVHDFQGQAIHTARWPHEPVTFEGKKVGIIGTGATGIQAIQEIVKTAGHLTVFQRTPNWSAPLNNGPISTDEMQEIRKAYPEIFKRCRESYSCFLHKSNPTSVFSVSAEEREKFWNELYKTKGFEKWLSNYHDIFTNKEANDLYSEFIANKIRERVHDPVTAEKLIPKCHGFGTKRVPLESGYFEAFNRPNVELVDVKSDPIERITAKGVKTRDSEYDLDILIYATGFDAVTGAFTAVDFQGVGGVKLKDKWKDGPRTFLGLWVESFPNMMMVMGPHQMFGNFPRSIEYAVGWVSRFIQNACERGISYAECTGKKVEEWTEHVHACAEGLLANNVDSWMTGVNKNLAHKQKRIIARYNGPAPGYRARADDVAHRGYEDLNMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>C8VRY6</accession>
    <name>C8VRY6_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation initiation factor eIF2B subunit beta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eIF2B GDP-GTP exchange factor subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ANIA_01344</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the eIF-2B alpha/beta/delta subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF87678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468996.1">
        <property type="nucleotide sequence ID" value="XM_050613159.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VRY6"/>
    <dbReference type="FunCoup" id="C8VRY6">
        <property type="interactions" value="1073"/>
    </dbReference>
    <dbReference type="STRING" id="227321.C8VRY6"/>
    <dbReference type="GeneID" id="2877122"/>
    <dbReference type="KEGG" id="ani:ANIA_01344"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN1344"/>
    <dbReference type="eggNOG" id="KOG1465">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016218_4_3_1"/>
    <dbReference type="InParanoid" id="C8VRY6"/>
    <dbReference type="OMA" id="SHSCAVA"/>
    <dbReference type="OrthoDB" id="269919at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005851">
        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002183">
        <property type="term" value="P:cytoplasmic translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006446">
        <property type="term" value="P:regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006413">
        <property type="term" value="P:translational initiation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10470:FF:000008">
        <property type="entry name" value="Translation initiation factor 2B, beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="entry name" value="Translation initiation factor eif-2b, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051855">
        <property type="entry name" value="eIF2B_beta_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45859">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45859:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="108"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="161"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="117"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="129"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CBF87678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="433" mass="46866" checksum="D0A0DD249D812B0E" modified="2009-11-03" version="1">MPATSAPLTPGLASFLKSLKTNPIDTSIDNLISLLKRRQIRHSRSCATATAYLLRSVISACRTSDASKLIERVQSVGRRLIAAQPREMVVGNIVRRVLGLIRDEAEDDRDGDFTLSDAGSESQPQTPRAGDEPSEFHGSDRGASKPISSLATHPVSMFSLLSHPEPETSLPGTPATGSPSGRLPGHTQNKDIRAEVLDGINEIIDELGQVDDQIAAYALDHIHSNEIILTHTSSTTVQKFLLKAAAKRKFTVIHAESYPNNHEATHATVSGAASNDDEILSTESFQKPLIAHGITVILIPDSAVFALMSRVNKVILGTHSVLANGGLVAAAGTRVIARAAKVHQTPCVVVSGVYKLSPVYPFDFESLIEYGDSSKVIDYEDGDLVDQIDVQNPLYDYVPAELVDLYITNLGGHAPSYLYRIVSDHYRKEDISF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>C8VU15</accession>
    <name>C8VU15_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha/beta hydrolase, putative (AFU_orthologue AFUA_1G02390)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ANIA_00325</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF89718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050469255.1">
        <property type="nucleotide sequence ID" value="XM_050610978.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VU15"/>
    <dbReference type="FunCoup" id="C8VU15">
        <property type="interactions" value="454"/>
    </dbReference>
    <dbReference type="STRING" id="227321.C8VU15"/>
    <dbReference type="ESTHER" id="emeni-c8vu15">
        <property type="family name" value="ABHD11-Acetyl_transferase"/>
    </dbReference>
    <dbReference type="GeneID" id="2876106"/>
    <dbReference type="KEGG" id="ani:ANIA_00325"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN0325"/>
    <dbReference type="eggNOG" id="KOG2382">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_53_0_1"/>
    <dbReference type="InParanoid" id="C8VU15"/>
    <dbReference type="OMA" id="FLGMSDN"/>
    <dbReference type="OrthoDB" id="8119704at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000039">
        <property type="entry name" value="Esterase ybfF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46118">
        <property type="entry name" value="PROTEIN ABHD11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46118:SF4">
        <property type="entry name" value="PROTEIN ABHD11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="44"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBF89718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="295" mass="33003" checksum="8D3720BA662A56B9" modified="2009-11-03" version="1">MLLSSRIALRSASSIRCFSTSSRHLRSDLSFQVYGPEKAHPRRNPIVFLHGLFGSKQNNRSISRAIARDLKREVYIVDLRNHGNSFHDTEHNYPVMADDVAEFIHKHDLSKCVLIGHSMGAKAAMTVALNAPELVSALVPVDNAPVNAPLRTDFDKYIKGMQHVESANVTKQSDADKILQEYEEALPIRQFLLTNLIRSPENQTMKFRVPLSTLGASLRAMGDFPFSQPGSVQYKGPTLVIRGTKSPYVSEDTFPIIKAFFPNSKIADVEAGHWLISENPEAFRKAVVDFLQEID</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>C8VU36</accession>
    <name>C8VU36_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_10064</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PP2C family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="1"/>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF89755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050469259.1">
        <property type="nucleotide sequence ID" value="XM_050610984.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VU36"/>
    <dbReference type="STRING" id="227321.C8VU36"/>
    <dbReference type="GeneID" id="74896181"/>
    <dbReference type="KEGG" id="ani:ANIA_10064"/>
    <dbReference type="eggNOG" id="KOG1379">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029404_1_0_1"/>
    <dbReference type="InParanoid" id="C8VU36"/>
    <dbReference type="OMA" id="FKTEGQW"/>
    <dbReference type="OrthoDB" id="25675at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.40.10:FF:000118">
        <property type="entry name" value="Phosphatase 2C-like domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039123">
        <property type="entry name" value="PPTC7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12320:SF24">
        <property type="entry name" value="PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12320">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU366020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF89755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="399" mass="44484" checksum="0AB22AB292D43C0C" modified="2009-11-03" version="1">MVPRIPGTPSAVSSSSSSLLRASATSSLPIDPRWSWGLKKTLVRRYHRAVWPSYGITTPVPDRSPHFPILKSPFYFQTGYALCAKRTSRPFPPPFLSPPSHSFSDPLTTHYHSQDKRLSVKGELIRGLNNGDDAVLVTENFLGVNDGVGAWATKPRGHAALWSRLILHFWALEVERIPSPDAAIDPIAYLQRAYEETTQATTSPSEWFGTTTSVTALLHKTLDGSGTEKPLLYVTNIGDCKVLVIRPSEKKVIFRTEEQWHWFDCPMQLGTNSMDTPQKDAVLSLVDLEEGDIVLAVSDGVLDNLWEHEVLSITLEGLDKWEHGRYNDKELEWAPPAVLAEEQMVFLARELLKSALAVAQDPFAESPYMEKAVEEGLAIQGGESDYIFDSSEPSSDYFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>C8VUF9</accession>
    <name>C8VUF9_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">L-dopachrome isomerase</fullName>
            <ecNumber evidence="9">5.3.2.1</ecNumber>
            <ecNumber evidence="8">5.3.3.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">L-dopachrome tautomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Phenylpyruvate tautomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">ANIA_00958</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>3-phenylpyruvate = enol-phenylpyruvate</text>
            <dbReference type="Rhea" id="RHEA:17097"/>
            <dbReference type="ChEBI" id="CHEBI:16815"/>
            <dbReference type="ChEBI" id="CHEBI:18005"/>
            <dbReference type="EC" id="5.3.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-dopachrome = 5,6-dihydroxyindole-2-carboxylate</text>
            <dbReference type="Rhea" id="RHEA:13041"/>
            <dbReference type="ChEBI" id="CHEBI:16875"/>
            <dbReference type="ChEBI" id="CHEBI:57509"/>
            <dbReference type="EC" id="5.3.3.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MIF family.</text>
    </comment>
    <dbReference type="EC" id="5.3.2.1" evidence="9"/>
    <dbReference type="EC" id="5.3.3.12" evidence="8"/>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF88442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_658562.2">
        <property type="nucleotide sequence ID" value="XM_653470.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VUF9"/>
    <dbReference type="GeneID" id="2876730"/>
    <dbReference type="KEGG" id="ani:ANIA_00958"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN0958"/>
    <dbReference type="eggNOG" id="ENOG502S2ZV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1372207_0_0_1"/>
    <dbReference type="InParanoid" id="C8VUF9"/>
    <dbReference type="OrthoDB" id="255819at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004167">
        <property type="term" value="F:dopachrome isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050178">
        <property type="term" value="F:phenylpyruvate tautomerase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.429.10">
        <property type="entry name" value="Macrophage Migration Inhibitory Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001398">
        <property type="entry name" value="Macrophage_inhib_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014347">
        <property type="entry name" value="Tautomerase/MIF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11954">
        <property type="entry name" value="D-DOPACHROME DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11954:SF6">
        <property type="entry name" value="MACROPHAGE MIGRATION INHIBITORY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55331">
        <property type="entry name" value="Tautomerase/MIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0202">Cytokine</keyword>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="145"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00036735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00036823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00042730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CBF88442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="199" mass="21517" checksum="A1438B86A38F6401" modified="2009-11-03" version="1">MAQIYQRSESFMFVSMQVIPSLRFGNSTVPAYSMKVFALPYLIAPITNLRSTILIQAALHDILHIQPSRGIILYIPVAEENMATNNTTMMGEVARLQSDTHGCGRESGIFKSLSRSLSRRKKSSSGASAPLSVATTSSWAARSDVHEAKPAAISESEGTNTSADEGSVRPRQSRTLRLFGSRRLTEPSEHSNAGSGIGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>C8VUM6</accession>
    <name>C8VUM6_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_00230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF89921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050469289.1">
        <property type="nucleotide sequence ID" value="XM_050611016.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VUM6"/>
    <dbReference type="GeneID" id="2876003"/>
    <dbReference type="KEGG" id="ani:ANIA_00230"/>
    <dbReference type="eggNOG" id="ENOG502RPNP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_162128_0_0_1"/>
    <dbReference type="InParanoid" id="C8VUM6"/>
    <dbReference type="OMA" id="FTGVGCT"/>
    <dbReference type="OrthoDB" id="4291851at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002993464" evidence="1">
        <location>
            <begin position="23"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF89921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="112" mass="12181" checksum="C8C34D5C28692616" modified="2009-11-03" version="1">MRTTSFSLFGLNLVLLISSTVAKTTTVGVETETESRGVSVPMDDCFDIDVDELTYPSRDVTTLAITKKCRVFTGPMCTGRTTLLEPGEHSSPEPVMLGSILCEEPEVFSTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>C8VUW5</accession>
    <name>C8VUW5_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Zn(II)2Cys6 transcription factor (Eurofung)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ANIA_00197</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF89994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050469300.1">
        <property type="nucleotide sequence ID" value="XM_050611029.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VUW5"/>
    <dbReference type="STRING" id="227321.C8VUW5"/>
    <dbReference type="GeneID" id="2875975"/>
    <dbReference type="KEGG" id="ani:ANIA_00197"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN0197"/>
    <dbReference type="eggNOG" id="ENOG502RYZ8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009377_1_1_1"/>
    <dbReference type="InParanoid" id="C8VUW5"/>
    <dbReference type="OMA" id="CMDLLGR"/>
    <dbReference type="OrthoDB" id="103819at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="12"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="101"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="56"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="101"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBF89994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="638" mass="70477" checksum="5848D120994B4A17" modified="2009-11-03" version="1">MADMTTLIQKRACEPCRNRKIRCDKSSPCSNCRLSGASCITLKPAARPKQARVLISSQYERKIDSIESRLDRLSNLVESLALQLHSAPPCQSAIQHSSTHRFATGDASSNNSTPDVCSRQVHGFPTLDDPAEKGRLLKGQSSSSLSAQSSFAVRFLHDAVDSKQERDITGEVTCLLKTISQFVESFSYQSLAATSLFPHARLEPAAGLPKYEMPPIEVTVSILREAQETDSVDIQLLAESFKMFLSSESLSDLCLKVYFSPEYSDAEFIIVNAALYFFATWAGVIQQQANSSLNDNPENLLSTCRVNLETALSRLPLYIQPSHEMVFALVLASSTILDSDITVPAPSSRTSSSPDSQLMEYFGYLVELARLAGRIYEELYCAGSLSLPVDVRRHRATESWLRSATQEHAQRIKSSTISEDVLRQSMLTLIYRAMPVQTGSSSTFNEESLESARAALEGHQSFIREFGTTDTDLLSGHITWSILFVPFVPFIVLFCHVIETGSLQDLSQMQAFVTSMESVCPHSPAIAKHYHLFHVFCTVAQRYCDIMSTASSSEEQRRLRMEVDAQLCAFGVQSQLPAGISGRIPNKRMSSLEADTSSPGANFGDGTIDAVDGFNLGDWFSFSQNIVGLLDRDDLPFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-12-14" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>G5EAX2</accession>
    <accession>C8V6D8</accession>
    <name>G5EAX2_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Phenylacetate 2-hydroxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ANIA_08078</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Aromatic compound metabolism; phenylacetate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF73838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_681347.1">
        <property type="nucleotide sequence ID" value="XM_676255.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G5EAX2"/>
    <dbReference type="SMR" id="G5EAX2"/>
    <dbReference type="STRING" id="227321.G5EAX2"/>
    <dbReference type="GeneID" id="2869025"/>
    <dbReference type="KEGG" id="ani:ANIA_08078"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN8078"/>
    <dbReference type="eggNOG" id="KOG0156">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_2_4_1"/>
    <dbReference type="InParanoid" id="G5EAX2"/>
    <dbReference type="OMA" id="DPRAYWQ"/>
    <dbReference type="OrthoDB" id="1055148at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11066">
        <property type="entry name" value="CYP_PhacA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000072">
        <property type="entry name" value="3-hydroxyphenylacetate 6 hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF9">
        <property type="entry name" value="P450, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0349">Heme</keyword>
    <keyword evidence="5 9" id="KW-0408">Iron</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="437"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00060591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBF73838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="518" mass="58495" checksum="9B5387AA59859A71" modified="2011-12-14" version="1">MSLQTIGIAAVAVVYFLIRYFNRTDIPKIKGLPEVPGVPIFGNLIQLGDQHATVAQKWAKKFGPVFQVRMGNKRVVFANTFDSVRQLWIKDQSALISRPTFHTFHSVVSSSQGFTIGTSPWDESCKRRRKAAATALNRPATQSYMPIIDLESMSSIRELLRDSANGTMDINPTAYFQRFALNTSLTLNYGIRIEGNVNDELLREIVDVERGVSNFRSTSNQWQDYIPLLRIFPKMNREAEEFRVRRDKYLTYLLDVLKDRIAKGTDKPCITGNILKDPEAKLNDAEIKSICLTMVSAGLDTVPGNLIMGIAYLASEDGQRIQKRAHDEIMKVYPDGDAWEKCLLEEKVPYVTALVKETLRFWTVIPICLPRENTKDIVWNGAVIPKGTTFFMNAYAADYDETHFTNPHAFEPERYLTASSDGSGTPHYGYGAGSRMCAGSHLANRELFTAYVRLITAFTMHPAKRAEDRPILDAIECNAIPTALTTEPKPFKVGFKPRDPVLVRKWIAESEERTKHLN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-08-14" modified="2026-01-28" version="121" xmlns="https://uniprot.org/uniprot">
    <accession>O60032</accession>
    <accession>C8VIM7</accession>
    <accession>Q5B8N5</accession>
    <name>HYMA_EMENI</name>
    <protein>
        <recommendedName>
            <fullName>Conidiophore development protein hymA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">hymA</name>
        <name type="ORF">AN3095</name>
    </gene>
    <organism>
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1999" name="Mol. Gen. Genet." volume="260" first="510" last="521">
            <title>Molecular characterization of HymA, an evolutionarily highly conserved and highly expressed protein of Aspergillus nidulans.</title>
            <authorList>
                <person name="Karos M."/>
                <person name="Fischer R."/>
            </authorList>
            <dbReference type="PubMed" id="9928930"/>
            <dbReference type="DOI" id="10.1007/s004380050924"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text>Required for conidiophore development.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location>Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Mo25 family.</text>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="erroneous gene model prediction">
            <sequence resource="EMBL-CDS" id="EAA63666" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EMBL" id="AJ001157">
        <property type="protein sequence ID" value="CAA04556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AACD01000051">
        <property type="protein sequence ID" value="EAA63666.1"/>
        <property type="status" value="ALT_SEQ"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF83417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468461.1">
        <property type="nucleotide sequence ID" value="XM_050612551.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O60032"/>
    <dbReference type="SMR" id="O60032"/>
    <dbReference type="FunCoup" id="O60032">
        <property type="interactions" value="375"/>
    </dbReference>
    <dbReference type="STRING" id="227321.O60032"/>
    <dbReference type="EnsemblFungi" id="CBF83417">
        <property type="protein sequence ID" value="CBF83417"/>
        <property type="gene ID" value="ANIA_03095"/>
    </dbReference>
    <dbReference type="GeneID" id="2874076"/>
    <dbReference type="KEGG" id="ani:ANIA_03095"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN3095"/>
    <dbReference type="eggNOG" id="KOG1566">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035755_0_0_1"/>
    <dbReference type="InParanoid" id="O60032"/>
    <dbReference type="OMA" id="AYDHKES"/>
    <dbReference type="OrthoDB" id="609103at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005933">
        <property type="term" value="C:cellular bud"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000131">
        <property type="term" value="C:incipient cellular bud site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071958">
        <property type="term" value="C:new mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035839">
        <property type="term" value="C:non-growing cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043539">
        <property type="term" value="F:protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007118">
        <property type="term" value="P:budding cell apical bud growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048315">
        <property type="term" value="P:conidium formation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030448">
        <property type="term" value="P:hyphal growth"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071574">
        <property type="term" value="P:protein localization to medial cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000100">
        <property type="term" value="P:regulation of establishment or maintenance of bipolar cell polarity regulating cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070507">
        <property type="term" value="P:regulation of microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000920">
        <property type="term" value="P:septum digestion after cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000257">
        <property type="entry name" value="Conidiophore development protein hymA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013878">
        <property type="entry name" value="Mo25"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10182">
        <property type="entry name" value="CALCIUM-BINDING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10182:SF3">
        <property type="entry name" value="PROTEIN MO25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08569">
        <property type="entry name" value="Mo25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000209835" description="Conidiophore development protein hymA">
        <location>
            <begin position="1"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="362"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="362"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="384" mass="44393" checksum="2E203D0D110C5FD6" modified="1998-08-01" version="1">MAFFFNRGRSRQPSDVVRSIKDLLLRLREPSTASKVEDELAKQLSQMKLMVQGTQELEASTDQVHALVQAMLHEDLLYELAVALHNLPFEARKDTQTIFSHILRFKPPHGNSPDPPVISYIVHNRPEIIIELCRGYEHSQSAMPCGTILREALKFDVIAAIILYDQSKEGEPAIRLTEVQPNVPQRGTGVFWRFFHWIDRGTFELSADAFTTFREILTRHKSLVTGYLATNFDYFFAQFNTFLVQSESYVTKRQSIKLLGEILLDRANYSVMMRYVESGENLKLCMKLLRDDRKMVQYEGFHVFKVFVANPDKSVAVQRILINNRDRLLRFLPKFLEDRTDDDQFTDEKSFLVRQIELLPKEPIEPSRSAREPSRSTANTTTVA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1988-11-01" modified="2026-01-28" version="150" xmlns="https://uniprot.org/uniprot">
    <accession>P08844</accession>
    <accession>C8VH97</accession>
    <accession>Q5B7L2</accession>
    <name>H2A_EMENI</name>
    <protein>
        <recommendedName>
            <fullName>Histone H2A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">htaA</name>
        <name type="synonym">hta1</name>
        <name type="ORF">AN3468</name>
    </gene>
    <organism>
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1987" name="Gene" volume="58" first="59" last="66">
            <title>The unique histone H2A gene of Aspergillus nidulans contains three introns.</title>
            <authorList>
                <person name="May G.S."/>
                <person name="Morris N.R."/>
            </authorList>
            <dbReference type="PubMed" id="3319784"/>
            <dbReference type="DOI" id="10.1016/0378-1119(87)90029-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>R153</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text>Core component of nucleosome which plays a central role in DNA double strand break (DSB) repair. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text>The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location>Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location>Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text>The [ST]-Q motif constitutes a recognition sequence for kinases from the PI3/PI4-kinase family.</text>
    </comment>
    <comment type="PTM">
        <text evidence="1">Phosphorylated to form H2AS128ph (gamma-H2A) in response to DNA double-strand breaks (DSBs) generated by exogenous genotoxic agents and by stalled replication forks. Phosphorylation is dependent on the DNA damage checkpoint kinases mec1/ATR and tel1/ATM, spreads on either side of a detected DSB site and may mark the surrounding chromatin for recruitment of proteins required for DNA damage signaling and repair. Gamma-H2A is removed from the DNA prior to the strand invasion-primer extension step of the repair process and subsequently dephosphorylated. Dephosphorylation is necessary for efficient recovery from the DNA damage checkpoint.</text>
    </comment>
    <comment type="PTM">
        <text evidence="1">Acetylated by esa1 to form H2AK4ac and H2AK7ac.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="3">In contrast to vertebrates and insects, its C-terminus is not monoubiquitinated.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the histone H2A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">To ensure consistency between histone entries, we follow the 'Brno' nomenclature for histone modifications, with positions referring to those used in the literature for the 'closest' model organism. Due to slight variations in histone sequences between organisms and to the presence of initiator methionine in UniProtKB/Swiss-Prot sequences, the actual positions of modified amino acids in the sequence generally differ. In this entry the following conventions are used: H2AK4ac = acetylated Lys-5; H2AK7ac = acetylated Lys-9; H2AS128ph = phosphorylated Ser-129.</text>
    </comment>
    <dbReference type="EMBL" id="M18258">
        <property type="protein sequence ID" value="AAA33309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AACD01000058">
        <property type="protein sequence ID" value="EAA63008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF82646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="A27332">
        <property type="entry name" value="A27332"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_661072.1">
        <property type="nucleotide sequence ID" value="XM_655980.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P08844"/>
    <dbReference type="SMR" id="P08844"/>
    <dbReference type="FunCoup" id="P08844">
        <property type="interactions" value="972"/>
    </dbReference>
    <dbReference type="STRING" id="227321.P08844"/>
    <dbReference type="EnsemblFungi" id="CBF82646">
        <property type="protein sequence ID" value="CBF82646"/>
        <property type="gene ID" value="ANIA_03468"/>
    </dbReference>
    <dbReference type="KEGG" id="ani:ANIA_03468"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN3468"/>
    <dbReference type="eggNOG" id="KOG1756">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062828_3_0_1"/>
    <dbReference type="InParanoid" id="P08844"/>
    <dbReference type="OMA" id="CALESQH"/>
    <dbReference type="OrthoDB" id="9421954at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00074">
        <property type="entry name" value="HFD_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000008">
        <property type="entry name" value="Histone H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002119">
        <property type="entry name" value="Histone_H2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032454">
        <property type="entry name" value="Histone_H2A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032458">
        <property type="entry name" value="Histone_H2A_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23430">
        <property type="entry name" value="HISTONE H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16211">
        <property type="entry name" value="Histone_H2A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00620">
        <property type="entry name" value="HISTONEH2A"/>
    </dbReference>
    <dbReference type="SMART" id="SM00414">
        <property type="entry name" value="H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00046">
        <property type="entry name" value="HISTONE_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0007">Acetylation</keyword>
    <keyword id="KW-0158">Chromosome</keyword>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0488">Methylation</keyword>
    <keyword id="KW-0544">Nucleosome core</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="initiator methionine" description="Removed" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000055322" description="Histone H2A">
        <location>
            <begin position="2"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="[ST]-Q motif">
        <location>
            <begin position="129"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="site" description="Not ubiquitinated" evidence="3">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-acetyllysine" evidence="1">
        <location>
            <position position="5"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-acetyllysine" evidence="1">
        <location>
            <position position="9"/>
        </location>
    </feature>
    <feature type="modified residue" description="N5-methylglutamine" evidence="1">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphoserine" evidence="1">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="132" mass="13979" checksum="538FACEA096EAE00" modified="2007-01-23" version="2">MTGGKSGGKASGSKNAQSRSSKAGLAFPVGRVHRLLRKGNYAQRVGAGAPVYLAAVLEYLAAEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGHVTIAQGGVLPNIHQNLLPKKTPKAGKGSQEL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1997-11-01" modified="2025-04-09" version="161" xmlns="https://uniprot.org/uniprot">
    <accession>Q12553</accession>
    <accession>C8VFY5</accession>
    <accession>Q5B1G7</accession>
    <name>XDH_EMENI</name>
    <protein>
        <recommendedName>
            <fullName>Xanthine dehydrogenase</fullName>
            <ecNumber>1.17.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Purine hydroxylase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">hxA</name>
        <name type="ORF">AN5613</name>
    </gene>
    <organism>
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1995" name="J. Biol. Chem." volume="270" first="3534" last="3550">
            <title>Cloning and molecular characterization of hxA, the gene coding for the xanthine dehydrogenase (purine hydroxylase I) of Aspergillus nidulans.</title>
            <authorList>
                <person name="Glatigny A."/>
                <person name="Scazzocchio C."/>
            </authorList>
            <dbReference type="PubMed" id="7876088"/>
            <dbReference type="DOI" id="10.1074/jbc.270.8.3534"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <scope>INDUCTION</scope>
        <source>
            <strain>biA1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Key enzyme in purine degradation. Catalyzes the oxidation of hypoxanthine to xanthine. Catalyzes the oxidation of xanthine to uric acid.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>xanthine + NAD(+) + H2O = urate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17712"/>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.17.1.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>hypoxanthine + NAD(+) + H2O = xanthine + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24670"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17368"/>
            <dbReference type="ChEBI" id="CHEBI:17712"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.17.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </cofactor>
        <text evidence="1">Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
        <text evidence="2">Binds 2 [2Fe-2S] clusters per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="5">By 2-thiouric acid. Repressed by ammonium.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the xanthine dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.17.1.4"/>
    <dbReference type="EMBL" id="X82827">
        <property type="protein sequence ID" value="CAA58034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AACD01000098">
        <property type="protein sequence ID" value="EAA62706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF81549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="A55875">
        <property type="entry name" value="A55875"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_663217.1">
        <property type="nucleotide sequence ID" value="XM_658125.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q12553"/>
    <dbReference type="SMR" id="Q12553"/>
    <dbReference type="STRING" id="227321.Q12553"/>
    <dbReference type="EnsemblFungi" id="CBF81549">
        <property type="protein sequence ID" value="CBF81549"/>
        <property type="gene ID" value="ANIA_05613"/>
    </dbReference>
    <dbReference type="GeneID" id="2871900"/>
    <dbReference type="KEGG" id="ani:ANIA_05613"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN5613"/>
    <dbReference type="eggNOG" id="KOG0430">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001681_1_2_1"/>
    <dbReference type="InParanoid" id="Q12553"/>
    <dbReference type="OMA" id="PHPTQER"/>
    <dbReference type="OrthoDB" id="8300278at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004854">
        <property type="term" value="F:xanthine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006145">
        <property type="term" value="P:purine nucleobase catabolic process"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009115">
        <property type="term" value="P:xanthine catabolic process"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.120:FF:000016">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000015">
        <property type="entry name" value="Aldehyde oxidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.365.10:FF:000003">
        <property type="entry name" value="Aldehyde oxidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1170.50:FF:000001">
        <property type="entry name" value="Aldehyde oxidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.365.10:FF:000001">
        <property type="entry name" value="Xanthine dehydrogenase oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.365.10:FF:000002">
        <property type="entry name" value="Xanthine dehydrogenase oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.365.10:FF:000004">
        <property type="entry name" value="Xanthine dehydrogenase oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.43.10:FF:000001">
        <property type="entry name" value="Xanthine dehydrogenase/oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.465.10:FF:000004">
        <property type="entry name" value="Xanthine dehydrogenase/oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.120">
        <property type="entry name" value="[2Fe-2S]-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.50">
        <property type="entry name" value="Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.365.10">
        <property type="entry name" value="Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.50">
        <property type="entry name" value="CO dehydrogenase flavoprotein, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002888">
        <property type="entry name" value="2Fe-2S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036884">
        <property type="entry name" value="2Fe-2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000674">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036856">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016208">
        <property type="entry name" value="Ald_Oxase/xanthine_DH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008274">
        <property type="entry name" value="AldOxase/xan_DH_MoCoBD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046867">
        <property type="entry name" value="AldOxase/xan_DH_MoCoBD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037165">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005107">
        <property type="entry name" value="CO_DH_flav_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036683">
        <property type="entry name" value="CO_DH_flav_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002346">
        <property type="entry name" value="Mopterin_DH_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014307">
        <property type="entry name" value="Xanthine_DH_ssu"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02963">
        <property type="entry name" value="xanthine_xdhA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45444">
        <property type="entry name" value="XANTHINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45444:SF3">
        <property type="entry name" value="XANTHINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01315">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03450">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00941">
        <property type="entry name" value="FAD_binding_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01799">
        <property type="entry name" value="Fer2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02738">
        <property type="entry name" value="MoCoBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20256">
        <property type="entry name" value="MoCoBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000127">
        <property type="entry name" value="Xanthine_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01008">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01092">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55447">
        <property type="entry name" value="CO dehydrogenase flavoprotein C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47741">
        <property type="entry name" value="CO dehydrogenase ISP C-domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54665">
        <property type="entry name" value="CO dehydrogenase molybdoprotein N-domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56003">
        <property type="entry name" value="Molybdenum cofactor-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-0001">2Fe-2S</keyword>
    <keyword id="KW-0274">FAD</keyword>
    <keyword id="KW-0285">Flavoprotein</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0411">Iron-sulfur</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0500">Molybdenum</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-0576">Peroxisome</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000166087" description="Xanthine dehydrogenase">
        <location>
            <begin position="1"/>
            <end position="1363"/>
        </location>
    </feature>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="3">
        <location>
            <begin position="35"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="4">
        <location>
            <begin position="266"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="1295"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="294"/>
            <end position="301"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="374"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="384"/>
            <end position="388"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="397"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="459"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="798"/>
        </location>
        <ligand>
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </ligand>
        <ligandPart>
            <name>Mo</name>
            <dbReference type="ChEBI" id="CHEBI:28685"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="829"/>
        </location>
        <ligand>
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </ligand>
        <ligandPart>
            <name>Mo</name>
            <dbReference type="ChEBI" id="CHEBI:28685"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="833"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="911"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="943"/>
        </location>
        <ligand>
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </ligand>
        <ligandPart>
            <name>Mo</name>
            <dbReference type="ChEBI" id="CHEBI:28685"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="945"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="1041"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="1110"/>
        </location>
        <ligand>
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </ligand>
        <ligandPart>
            <name>Mo</name>
            <dbReference type="ChEBI" id="CHEBI:28685"/>
        </ligandPart>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; CAA58034." evidence="6" ref="1">
        <original>R</original>
        <variation>H</variation>
        <location>
            <position position="741"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="P22985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="7876088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="6"/>
    <sequence length="1363" mass="149523" checksum="18D8F50B731EDE4B" modified="2007-05-01" version="2">MAPGVLLQPSQSELEAASPPKAAASLLQLTEEWDDTIRFYLNGTKVILDSVDPEITLLEYLRGIGLTGTKLGCAEGGCGACTVVVSQINPTTKKLYHASINACIAPLVAVDGKHVITVEGIGNVKNPHAIQQRLAIGNGSQCGFCTPGIVMSLYALLRNDPKPSEHAVEEAFDGNLCRCTGYRPILDAAQSFTSPIGCGKARANGGSGCCMEEQKGTNGCCKGSSEETTEDVKHKFASPDFIEYKPDTELIFPPSLWKHELRPLAFGNKRKKWYRPVTVQQLLEIKSIHPDAKLIGGSTETQIEIKFKQMRYGASVYLGDLAELRQFAFHDNYLEIGANISLTDLESVCDQAIERYGSARGQPFAAIKKQLRYFAGRQIRNVASPAGNLATASPISDLNPVFVATNTTLVARSLDKETEIPMTQFFRGYRSTALPPDAIISSLRIPTASEKGEYLRAYKQSKRKDDDIAIVNAALRVSLSSSNDVTSVSLVFGGMAPLTVSARNAEAFLTGKKFTDPATLEGTMGALEQDFNLKFGVPGGMATYRKSLALGFFYRFYHDVLSQIEARSSDLDNSVVAEIERAISTGEKDNEASAAYQQRVLGRAGPHLSALKQATGEAQYTDDIPAQKNELYGCMVLSTKAHAKLLSVNTEAALEIPGVIDYVDHKDLPSPRANWWGAPNCDEVFFAVDKVTTAGQPIGMILANTAKAAEEGARAVKVEYEELPVILSIEEAIEAQSFFERFRYIKNGDPESAFRDADHVFEGVSRMGGQEHFYLETQACVAIPKAEDGEMEIWSSTQNPTETQSYVAQVTGVAANKIVSRVKRLGGGFGGKETRSVQLAGICATAAAKVRRPVRCMLNRDEDIATSGQRHPFYCKWKVGVTREGKLLALDADVYANGGHTQDLSGAVVERSLSHIDNVYRFPNIYVRGRICKTNTVSNTAFRGFGGPQGLFFAESIISEVADHLDLQVEQLRILNMYEPGDMTHFNQELKDWHVPLMYDQVLQESEYFERRKAVEEYNRTHKWSKRGMAIIPTKFGISFTALFLNQAGALVHIYHDGSVLVAHGGVEMGQGLHTKMTMIAAEALGVPLSDVFISETATNTVANTSSTAASASSDLNGYAIYNACTQLNERLKPYREKMPNATLKDLAHAAYFDRVNLSAQGYYRTPDIGYTWGENKGQMFFYFTQGVTAAEVEIDTLTGDWTPLRADIKMDVGRTINPSIDYGQIEGAYIQGQGLFTTEESLWHRTTGQIFTKGPGNYKIPGFRDIPQIFNVSLLKDVEWENLRTIQRSRGVGEPPLFMGSAAFFAIRDALKAARKEWGVTDVLSLVSPATPERIRVSCADPIIERARVKAEEGEKSFFVAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ARP4</accession>
    <accession>C8VKR3</accession>
    <name>Q5ARP4_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ANIA_09036</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF84417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_682305.1">
        <property type="nucleotide sequence ID" value="XM_677213.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ARP4"/>
    <dbReference type="STRING" id="227321.Q5ARP4"/>
    <dbReference type="GeneID" id="2868205"/>
    <dbReference type="KEGG" id="ani:ANIA_09036"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN9036"/>
    <dbReference type="eggNOG" id="ENOG502SM6F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028200_6_2_1"/>
    <dbReference type="InParanoid" id="Q5ARP4"/>
    <dbReference type="OMA" id="DWTILAC"/>
    <dbReference type="OrthoDB" id="2496787at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF141">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="237"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="276"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="36"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBF84417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="401" mass="44082" checksum="F0191D7D4EC5B02D" modified="2005-04-26" version="1">MGVTSTVCEIPPRNRKSTQLAVGWIFIVLTTLALGLRLMARPPLSASFGIDDGIGIGTYVQLLSCTALVDMILMIQGANLGWGTDMWALQAEQIILQMKVDANLQPIFILFTNNSTLCQLFYAGIIAFYLSVSLAKLSILFFYLRIFTTDTFKRIAYTMIFLCSAYGVGSVVTSILDCMPPSYFWTRFDGVSTGYCVSKAAFKVIPPVNIALDVVVMVLPLPLLARLNLPLQKKIRVLSMFSMGVLIIVADILRITHLFHSITAYNITYNGGELSYFGVIESGVGVICICMPAIAALLKRVLPQCFGSLAKRSYLYRTINSRSNTEFGASRSRSQRGAIQPSAYAHTNPNNPVSFSAIAWGAREDERDGDGNTSDIHLTLLPATEIADERIQRPQKALTSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="104" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ARR9</accession>
    <accession>C8VKZ0</accession>
    <name>Q5ARR9_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ANIA_09011</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF84465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_682280.1">
        <property type="nucleotide sequence ID" value="XM_677188.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ARR9"/>
    <dbReference type="GeneID" id="2868258"/>
    <dbReference type="KEGG" id="ani:ANIA_09011"/>
    <dbReference type="eggNOG" id="KOG1238">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002865_6_0_1"/>
    <dbReference type="InParanoid" id="Q5ARR9"/>
    <dbReference type="OMA" id="GINYMMY"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF210">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE OXIDOREDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="5">
        <location>
            <begin position="103"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="6">
        <location>
            <begin position="293"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="153"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBF84465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="617" mass="66045" checksum="79AE61BC078EC25A" modified="2005-04-26" version="1">MTQSQVHESGDSPVASIEEFTTTPFDFIVCGGGTAGLAIAARLSEISNVNVGIVEAGKYRIGDPLIETPATFMQMFEDPEYDWCLFTAPQEANNGKVHHIPRGKVLGGSSAINYLMYVRGSLQDYDDWAALVGDEGWSAANMKAYMRKHQAQPVNPESKAAASPIAPEHHGTTGPIRTSFNESNLPIETDFVKACAETANLPNMPIDAWSGDHIGFYHTLGAVARTGPNRGKRSYAGIEYYEANRLRPNLKLLCEARVNKVILNGTRATGVSITFRGQEYTVSASREVIVSGGTIQSPQILELSGIGDPEVLAASGVQCLVENRAVGANVQDHSVSLISWQMQPGVVTSDTLGQVPEAAAAALHQYAESRTGPLSSIGSTQGFIPVKSILSDAELAEIVQSIRDIKPSSAFHEKQLQQVIAHLESETSANLQVVFLPCSVHENGVEHQRGLFTPPPVGEPVCVSAAPCLQYPVSRGSIHINSNDPSVPPTIQPNYISHSADVALLAAFLSWIDRVGHAAPFASSVSRRILPKSSLDLQDSEQAKRAIHDTVIGEYHICGSVAMGDALDSRLRVKGVEGLRVVDASVFPNNVSGNIMSSVYAVAEKGADLVKEDHGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ARX2</accession>
    <accession>C8VL97</accession>
    <name>Q5ARX2_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_08958</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF84571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_682227.1">
        <property type="nucleotide sequence ID" value="XM_677135.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ARX2"/>
    <dbReference type="GeneID" id="2868285"/>
    <dbReference type="KEGG" id="ani:ANIA_08958"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN8958"/>
    <dbReference type="HOGENOM" id="CLU_074380_0_0_1"/>
    <dbReference type="InParanoid" id="Q5ARX2"/>
    <dbReference type="OMA" id="YEAHVLY"/>
    <dbReference type="OrthoDB" id="4480078at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010175682" evidence="1">
        <location>
            <begin position="25"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF84571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="265" mass="28992" checksum="7792B0C28E813020" modified="2005-04-26" version="1">MSSLLQAKPHLTAALSFLAFGASACRNIIESSEGAPGPPQRTDKSALLSEWPGSNGIKRETQKTHWVTSLVALQVDVPVAQLVRCGISEVGDAYDLARNLFSAFLDARARGLEAWFLDKDVPQLSFTPWSLLFGRSHSAGAFMLGHWSSARRIQLDQPILHSETANPICEFRPSKAMITASNINAETDAAGTVLYWKFPRRSVDQVDKAASYGIPWRLMEGAFQEFIVEKITSETTKVTYVTVGCGNMYPGGQRERTSKGAVVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="112" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ARX6</accession>
    <accession>C8VLA2</accession>
    <name>Q5ARX6_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ANIA_08954</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF84580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_682223.1">
        <property type="nucleotide sequence ID" value="XM_677131.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ARX6"/>
    <dbReference type="STRING" id="227321.Q5ARX6"/>
    <dbReference type="GeneID" id="2868219"/>
    <dbReference type="KEGG" id="ani:ANIA_08954"/>
    <dbReference type="eggNOG" id="ENOG502RVFM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_568611_0_0_1"/>
    <dbReference type="InParanoid" id="Q5ARX6"/>
    <dbReference type="OMA" id="TWRMIAL"/>
    <dbReference type="OrthoDB" id="300709at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF14">
        <property type="entry name" value="SNOAL-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13577">
        <property type="entry name" value="SnoaL_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010237704" evidence="3">
        <location>
            <begin position="18"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="NmrA-like" evidence="4">
        <location>
            <begin position="128"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="SnoaL-like" evidence="5">
        <location>
            <begin position="325"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBF84580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="480" mass="54337" checksum="8D5B90DE54781DB6" modified="2005-04-26" version="1">MSDRKLILVMGILALRALPLSRVRRIPDGIARNSSLTWRMIALSSSGRYDVRVLTRNTASEQARKMVVLPQVTLQQGFQETRQISTLPSPAYTAPGRLYARGKSELIYGIRAYEIARHHGVKHYVFANIDYTLRKAGKEDGSFAWENPAADGKIPLIALDDVGVYSLWLFDNPSQSAGLNLEVATDQVSFAEIATTFTKVTRKKGIHKRLSLDEYLDEAELYPGAYANWAVASDVPRDESFMTWRENFTAWWGYWSEGKGATRDMALMDRIHPSRIPSLEAWMRMKGYDGRPRLHPPYPIIMASFLVDGRFPPVPLPPSKDIKSEERSTAIDFVNRHNLIFQEFNYDKVTATFLPDAIVYHSHGTIRGHAEIKQFLENVYGFFIPGIGRSATNHVVDRDENGGVVVRYQETLIRYGWGEGEPDADVVAGRDIVRADGLPAIWWFGQVVDRLRIAANGWRILERYLGGSFRNQSLDLTNKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ASB2</accession>
    <accession>C8V9L8</accession>
    <name>Q5ASB2_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_08818</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF77958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_682087.1">
        <property type="nucleotide sequence ID" value="XM_676995.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ASB2"/>
    <dbReference type="GeneID" id="2868439"/>
    <dbReference type="KEGG" id="ani:ANIA_08818"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN8818"/>
    <dbReference type="HOGENOM" id="CLU_1643688_0_0_1"/>
    <dbReference type="InParanoid" id="Q5ASB2"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF77958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="161" mass="18245" checksum="73971C27D5864B1D" modified="2005-04-26" version="1">MKPILERFLQIPLHCFLGSISSNKDNDCCPSSHRCTDLLSNIAPSIFYKDTLARFYDPRYEPAFSNPKILHPDHEAVTANPAPGDGEFRPVSPGLTSYSDVKSERVTGIAYDDYLTFLDNGASGSGISRRESELRAFARYKERYHEYLHEIASVKVGKRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="107" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ASE1</accession>
    <accession>C8V9P9</accession>
    <name>Q5ASE1_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">MFS monocarboxylate transporter, putative (AFU_orthologue AFUA_2G12710)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ANIA_08789</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF78016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_682058.1">
        <property type="nucleotide sequence ID" value="XM_676966.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ASE1"/>
    <dbReference type="GeneID" id="2868454"/>
    <dbReference type="KEGG" id="ani:ANIA_08789"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN8789"/>
    <dbReference type="eggNOG" id="KOG2504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_1_2_1"/>
    <dbReference type="InParanoid" id="Q5ASE1"/>
    <dbReference type="OMA" id="MITTCAF"/>
    <dbReference type="OrthoDB" id="6499973at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF284">
        <property type="entry name" value="EG:103B4.3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="35"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="277"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="322"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="361"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="400"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="431"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="477"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="5">
        <location>
            <begin position="35"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBF78016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="506" mass="54714" checksum="1FA752B3269876BD" modified="2005-04-26" version="1">MGSVVELASREADGSPQTASPQTNEAEQEHPTWKYALVVAAGFSVMFTTCAFIFSYGVYQSLYEEMAEAEGTPFTGSSTALINLVGILAIALMSMGGPFAMHWSKIYSPQAVIIAGGWVFGIAYILSSFGQALWHFALTQGVLLGIGTCLAYVPTMSVAPTWFDQRRGLAMGVIISGSAVGGMVWPPALRAMITHLGFRNALRISGCISLTLVSVAGYALRWEPKFHEQVRIQTQGLRRRSGWIKAPMVNYRVARSKRFLAQALGCFLQSAGYSTPLFFYAAYASTLGYSPTTAANFITLNNASNFVSRIAIGYGADRYGRINALVVTTLLSAVAVFAFWIPSMFHTPDAGVPKSSADGLFIVFTILYGAFASAYISLFPASLIELFGVQHFTSVNGALYLIRGMGALIGTPLTGMLIPKDALTSSFIYERAGIVVGVLLVAATLACLWVRIEASLGSSWTMESVNMHIRAMRSKRTVLRLGPALWLLSEGLYTQGVTWLVSELRM</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-03-21" modified="2026-01-28" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ASI2</accession>
    <accession>C8V9Z3</accession>
    <name>APTH1_EMENI</name>
    <protein>
        <recommendedName>
            <fullName>Acyl-protein thioesterase 1</fullName>
            <ecNumber evidence="2">3.1.2.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Palmitoyl-protein hydrolase</fullName>
            <ecNumber evidence="2">3.1.2.22</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name type="ORF">AN8748</name>
    </gene>
    <organism>
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Hydrolyzes fatty acids from S-acylated cysteine residues in proteins with a strong preference for palmitoylated G-alpha proteins over other acyl substrates. Mediates the deacylation of G-alpha proteins such as GPA1 in vivo, but has weak or no activity toward palmitoylated Ras proteins. Has weak lysophospholipase activity in vitro; however such activity may not exist in vivo.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>S-hexadecanoyl-L-cysteinyl-[protein] + H2O = L-cysteinyl-[protein] + hexadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19233"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="3.1.2.22"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.-" evidence="2"/>
    <dbReference type="EC" id="3.1.2.22" evidence="2"/>
    <dbReference type="EMBL" id="AACD01000161">
        <property type="protein sequence ID" value="EAA60541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF78105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_682017.1">
        <property type="nucleotide sequence ID" value="XM_676925.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ASI2"/>
    <dbReference type="SMR" id="Q5ASI2"/>
    <dbReference type="FunCoup" id="Q5ASI2">
        <property type="interactions" value="475"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5ASI2"/>
    <dbReference type="ESTHER" id="emeni-apth1">
        <property type="family name" value="LYsophospholipase_carboxylesterase"/>
    </dbReference>
    <dbReference type="MEROPS" id="S09.941"/>
    <dbReference type="EnsemblFungi" id="CBF78105">
        <property type="protein sequence ID" value="CBF78105"/>
        <property type="gene ID" value="ANIA_08748"/>
    </dbReference>
    <dbReference type="KEGG" id="ani:ANIA_08748"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN8748"/>
    <dbReference type="eggNOG" id="KOG2112">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049413_3_8_1"/>
    <dbReference type="InParanoid" id="Q5ASI2"/>
    <dbReference type="OMA" id="WYDILAM"/>
    <dbReference type="OrthoDB" id="2418081at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000010">
        <property type="entry name" value="Acyl-protein thioesterase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050565">
        <property type="entry name" value="LYPA1-2/EST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003140">
        <property type="entry name" value="PLipase/COase/thioEstase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655:SF17">
        <property type="entry name" value="LYSOPHOSPHOLIPASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655">
        <property type="entry name" value="LYSOPHOSPHOLIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02230">
        <property type="entry name" value="Abhydrolase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0276">Fatty acid metabolism</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0443">Lipid metabolism</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0719">Serine esterase</keyword>
    <feature type="chain" id="PRO_0000229009" description="Acyl-protein thioesterase 1">
        <location>
            <begin position="1"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="1">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="1">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="1">
        <location>
            <position position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="Q12354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="239" mass="26553" checksum="74BF28A872ACA8DF" modified="2005-04-26" version="1">MSRAPFIVPALKKHTATVIMAHGLGDSGAGWVSLAHNWRRRGLFEEVTFIFPNAPMIPITVNFGMSMPGWYDITKLGRDLDFQEAVKNQDEAGILKSRDYFNSLIKEQMDQGIKPSRIVLGGFSQGGAMSLFSGITGQEKLGGVFGLSCYMLLSDRIKNYIPENFPNKKTPFFLAHGTEDDIVPHEFGKRSAEMAKELGLEDVTFNSYKYLSHSADPVEIEDLEKFLDRVIPAENGGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="99" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ASN3</accession>
    <accession>C8VA52</accession>
    <name>Q5ASN3_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_08697</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF78217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_681966.1">
        <property type="nucleotide sequence ID" value="XM_676874.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ASN3"/>
    <dbReference type="STRING" id="227321.Q5ASN3"/>
    <dbReference type="GeneID" id="2868519"/>
    <dbReference type="KEGG" id="ani:ANIA_08697"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN8697"/>
    <dbReference type="eggNOG" id="ENOG502RY8V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031479_1_0_1"/>
    <dbReference type="InParanoid" id="Q5ASN3"/>
    <dbReference type="OMA" id="CAIHIIM"/>
    <dbReference type="OrthoDB" id="336240at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="529"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="592"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="529"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="599"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF78217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="617" mass="69567" checksum="A8031F287C3F5488" modified="2005-04-26" version="1">MNPNTAAFVPGHSYKQSDGDVVSINGFPDSNTAPYLSSSDITPSVSEFPSMESLRTSLQIHSGPYQDACNLVNRTQITMMPQLSRTPHETELVSRSSQCTEPSPLHHLSNPDLQDVPERSSVLAVYTQSVDKTTNPGYMPIGSLVNLKGPPKWGVVKISNIPYGVTKPEVFQFIGRQARPITEEMGCPIHIIMERSTAKTMDCYVEFQTVPDAFETVERINRVQSNGRVPRLGGRHVDVEVSDQDALLKDLFPRANCVKWEAGMPKIQPNHDQIACSGFNGFFTSEEIIMAIRHAELPKRSPFSEKCPQRTYESTISTLYKFPWYAPWTYTVADRNQLFELANRHIQCLATGIKHKTVGLLEKLLRELLQAGLSCPGFSERQKYTLCMNSQIESEINKLSVMSKWFPFDTLSNKPDFDEDIHIYYADLISQSVVPDLRNSGLINKFPMDMPYLSSPYGRIWLEWSQNAAKVHWEDAVEYEMKILHDLVLHGWMNDDRSNMLNLNLRRPSGELSFSRGLSDRRNMSLSLYTSDTDESQAQTDSSSRSGVYMPHFRRASESAGSGRISGLSGPSSTWTHALLLDSSFEARPAYRHHRKTESSPMCLTPTTNNWSPEMTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="105" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ASX6</accession>
    <accession>C8VAG7</accession>
    <name>Q5ASX6_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family acetyltransferase, putative (AFU_orthologue AFUA_7G00850)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_08604</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
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    <dbReference type="EMBL" id="BN001303">
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF78348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="236" mass="26792" checksum="2491C9596F46FFD1" modified="2005-04-26" version="1">MSNQPVGAIVELPVSTHPAPTTLTGRSINLVPLKITHADELFPLVNNADSFQTALWDYIPDGPYDDVAHLRADFAAREISKDPVFFAIIDTRPSRPTTGNAIGYIAFMNISPEHRRIEIGHVIFTMALQRTIGATEAVYLLLQHAIEELGYRRVEWKCNALNEGSRRAALRLGFQFEGVFRQHMVVKGRNRDTAWFSIVREEWPELKKAFDGWLDEGNFDENGAQRRRLEEFRASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="126" xmlns="https://uniprot.org/uniprot">
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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    <reference evidence="6" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
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            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
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        <property type="match status" value="2"/>
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        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010324819" evidence="2">
        <location>
            <begin position="24"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoside phosphorylase" evidence="4">
        <location>
            <begin position="11"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="NB-ARC" evidence="3">
        <location>
            <begin position="361"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1091"/>
            <end position="1127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBF80770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="1136" mass="127482" checksum="BD24A87E0AFA67B4" modified="2005-04-26" version="1">MRPRSRNEFAIAIICALTLEADAVEAVFDVTYDRLGRDYGKEPGDANTYVNGRIGGHNVVLCYLPRKGKGSAASVASSLQVSYRNIRLALVVGICGGAPSIGEDQIYLGDVVISDSVVEYDYGRQYPGGFQRKTNVEDTLGGLDRRLGTFLSGLKATRTMAEFGRRVSECLNTLQQSEPRWGRPGIADVLYEAAYLHRHYTNDGSIKCNCAEECTSDNICEIALQKDCDELGCEDTHIVRRRAAGESVPSVYVRKVASADTVLKSGQYRDAIVRTENVAAFEMEGAGVWNNLPCVIIKGVCDYSDSHKNKLWQAYAAATAASATKVFLEYWKPLQSDDAATAGYFMLPFMRNPRFVGRHHELQELEEWIATPDGPRKLAITGLGGVGKTQVALELAYRMRDREPRCSIFWIPCITREAVEQAYLAIADTIGIHADRDSVKEQLQRYFTETKEQWLLIFDNADDIDMWTDGSETLPALQEFLPQSNQGHILFTTRNRKAAVKMASASNYVTHVAEPSENDGLEMLRRSLIDKKLLDDPEVCITLLEQLCFLPLAITQATAFINENSIGLSDYLELLSEQEAAVTELLSKEFGDEGRYQDVQNPVALTWHISFKQILEMDAMAADYLSLLACVHSRDIPQSFLPQPKSKTALIETLGLLKAYSFVTLQGNGSISMHRLVSLAMRNWLNMRNKLSAYVLWAADRFEEIFPDPDHINRRLWRQFLPHVLHLLDEAAFKEAQSKGRYLLLVDDIMGCLWKENRHREAEPLARDLMTYYQKAYGDSDRRTLSCMNDLVYCYLHQDKISQAEEVALQATSICRETLGLADRTTATSMSFLVQVYVHQGKYKEAEKLQLEVLSTSGDVENSLRGISNLASIYSDLGRAEEAAKLRQKVLKLETESLGVDHPDTIATMHNLAQTYESQGRLAEAEDLAVQVLKTNKRVLGLKHPSTARSMATLAVVYRGQGRLEEAEELLIEAVDISQHVFGTTHTYTVTMTSELATTYYLQERWSEAEEIQDHVLKLRMEKLGPMHPDTLLSMYRLALTWRAAGAQALAIQMMEECFERSAKYLGPDHPATIWSKKELDNWEDLDNAEADSTGAVSLSNKPRGLSGPGDAGEEKTSQPVRRRKREIISRFICSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="120" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ATD5</accession>
    <accession>C8VEF6</accession>
    <name>Q5ATD5_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Peptide hydrolase</fullName>
            <ecNumber evidence="14">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">ANIA_08445</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="19">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M28 family. M28A subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="14"/>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF80569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_681714.1">
        <property type="nucleotide sequence ID" value="XM_676622.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ATD5"/>
    <dbReference type="SMR" id="Q5ATD5"/>
    <dbReference type="STRING" id="227321.Q5ATD5"/>
    <dbReference type="GeneID" id="2868791"/>
    <dbReference type="KEGG" id="ani:ANIA_08445"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN8445"/>
    <dbReference type="eggNOG" id="KOG2195">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024336_0_2_1"/>
    <dbReference type="InParanoid" id="Q5ATD5"/>
    <dbReference type="OMA" id="VRFCFWT"/>
    <dbReference type="OrthoDB" id="2214at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd03876">
        <property type="entry name" value="M28_SGAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02130">
        <property type="entry name" value="PA_ScAPY_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000054">
        <property type="entry name" value="Peptide hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.30.30:FF:000030">
        <property type="entry name" value="Peptide hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041756">
        <property type="entry name" value="M28_SGAP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046450">
        <property type="entry name" value="PA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="METALLOPEPTIDASE M28 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147:SF57">
        <property type="entry name" value="PEPTIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52025">
        <property type="entry name" value="PA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 18" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="7 14" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="9 14" id="KW-0732">Signal</keyword>
    <keyword evidence="11 14" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010392549" description="Peptide hydrolase" evidence="14">
        <location>
            <begin position="18"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="PA" evidence="16">
        <location>
            <begin position="121"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="17">
        <location>
            <begin position="233"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="477"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="477"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CBF80569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="503" mass="54062" checksum="319122E49FBB92F3" modified="2005-04-26" version="1">MKSILVPALSLASLAWAGKHKPLVTPEALQDLITLDDLLAGSQQLQDFAYAYPERNRVFGGRAHDDTVNWLYRELKRTGYYHVYKQPQVHLYSNAEESLTVNGEAIEATTMTYSPSANASAELAVISGLGCSPADFASDVAGKVVLVQRGNCTFGEKSVYAAAADAAATIVYNNVEGSLSGTLGAAQSEQGPYSGIVGISLADGEALLALAEEGPVHVDLWIDSVMENRTTYNVIAQTKGGDPDNVVTLGGHSDSVEAGPGINDDGSGIISNLVIARALTKFSTKHAVRFFFWTAEEFGLLGSDYYVSSLSPAELAKIRLYLNFDMIASPNYGLLLYDGDGSAFNLTGPAGSDAIEKLFYDYFQSIGQATVETEFDGRSDYEAFILNGIPAGGVFTGAEEIKSEEEVALWGGEAGVAYDANYHQVGDTIDNLNTEAYLLNSKATAFAVATYANDLSTIPKREMTTAVKRANVNGHMHRRTMPKKRQTAHRHAAKGCFHSRVEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ATL8</accession>
    <accession>C8VE56</accession>
    <name>Q5ATL8_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_08362</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF80385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_681631.1">
        <property type="nucleotide sequence ID" value="XM_676539.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ATL8"/>
    <dbReference type="GeneID" id="2868637"/>
    <dbReference type="KEGG" id="ani:ANIA_08362"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN8362"/>
    <dbReference type="eggNOG" id="ENOG502S9HK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050866_1_1_1"/>
    <dbReference type="InParanoid" id="Q5ATL8"/>
    <dbReference type="OMA" id="MECNEYS"/>
    <dbReference type="OrthoDB" id="9970474at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.400.10">
        <property type="entry name" value="Acetoacetate decarboxylase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023375">
        <property type="entry name" value="ADC_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40518">
        <property type="entry name" value="ACETOACETATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40518:SF1">
        <property type="entry name" value="ACETOACETATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160104">
        <property type="entry name" value="Acetoacetate decarboxylase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF80385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="314" mass="34546" checksum="686FF55B479F786A" modified="2005-04-26" version="1">MAPFIPPPPSPDKPGTLPPDTGSAIPIPISPPPWTLRARSWTFLYTSSSPNAPLEASSQNPNNTPEVLQSVLPAGAYHPFETIHASALQRLSDGTSQFRETWLKAVMIVRYEETDVGPYDELAFIPGRAANPETGKKEIRISSIYVSTDASVWNGRRNWNIPKYRARFEFTPVGADTALRVYHPENSPAPLDSKTPFFTVLLKSSSLPRLPLPRLAPLTIAQPPLAKSRWPPGIQDAVIATDDPENGRENQWLNITPSFKGRWGLAYAHTLEEKDGKETLQSHGDGLGFPKVKLRCLGGYFEGEIEFGIADIVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AUV3</accession>
    <accession>C8V4W7</accession>
    <name>Q5AUV3_EMENI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_07927</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
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        <lineage>
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            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF73537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_681196.1">
        <property type="nucleotide sequence ID" value="XM_676104.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AUV3"/>
    <dbReference type="STRING" id="227321.Q5AUV3"/>
    <dbReference type="GeneID" id="2869199"/>
    <dbReference type="KEGG" id="ani:ANIA_07927"/>
    <dbReference type="eggNOG" id="ENOG502SRGH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067182_1_0_1"/>
    <dbReference type="InParanoid" id="Q5AUV3"/>
    <dbReference type="OMA" id="RTIQYQA"/>
    <dbReference type="OrthoDB" id="5620at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF73537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="202" mass="23424" checksum="530AB4E24725EA47" modified="2005-04-26" version="1">MPSQAAKPSAAERRLARSHAARSTHARARRLRTIQYQAQKAQDASNELQEDSGELPQYGLLHALSYYRRDPFESSARRLRPMEQMFFDHYLTVIIPLMRCNGLDVEFYRRMTLSWIPLALSDDGLLNVLFLAACRHLSECYQTRPQAEPFSRMAFQYKLRLLRSLREEISAETAHFTDASVIKAIMLAYDEEKLSRRLLINA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AUZ3</accession>
    <accession>C8V4I5</accession>
    <name>Q5AUZ3_EMENI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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    </protein>
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        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
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            <taxon>Aspergillaceae</taxon>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF73459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_681156.1">
        <property type="nucleotide sequence ID" value="XM_676064.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AUZ3"/>
    <dbReference type="GeneID" id="2869260"/>
    <dbReference type="KEGG" id="ani:ANIA_07887"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN7887"/>
    <dbReference type="HOGENOM" id="CLU_1570633_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AUZ3"/>
    <dbReference type="OMA" id="TMYARTH"/>
    <dbReference type="OrthoDB" id="3445803at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010175683" evidence="1">
        <location>
            <begin position="28"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF73459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="170" mass="18620" checksum="ED3886A683F8E98C" modified="2005-04-26" version="1">MRLSSILKCAVLAQFAVSSALPSKSQGNDYTRLSSAFGCQLYGFPDNEDGSANNAIPPNLRSGSRFKYCPAGGAQLTSPSLRDARGTRGSLDAVHYPGDAGDEGDWVHFDDFMGQGIAFIKNNNMQDGLELDLWNGPDSTLFWNTDYSQYLETWTRMCKRFNLTNTGAVP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2018-05-23" modified="2025-06-18" version="121" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AV02</accession>
    <accession>A0A1U8QYE8</accession>
    <accession>C8V3Y3</accession>
    <name>ATNH_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Branched-chain-amino-acid aminotransferase atnH</fullName>
            <ecNumber evidence="7">2.6.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Aspercryptin biosynthesis cluster protein H</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">atnH</name>
        <name type="ORF">ANIA_07878</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="E99" last="E107">
            <title>Accurate prediction of secondary metabolite gene clusters in filamentous fungi.</title>
            <authorList>
                <person name="Andersen M.R."/>
                <person name="Nielsen J.B."/>
                <person name="Klitgaard A."/>
                <person name="Petersen L.M."/>
                <person name="Zachariasen M."/>
                <person name="Hansen T.J."/>
                <person name="Blicher L.H."/>
                <person name="Gotfredsen C.H."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Mortensen U.H."/>
            </authorList>
            <dbReference type="PubMed" id="23248299"/>
            <dbReference type="DOI" id="10.1073/pnas.1205532110"/>
        </citation>
        <scope>IDENTIFICATION OF THE CLUSTER</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2016" name="ACS Chem. Biol." volume="11" first="2117" last="2123">
            <title>New aspercryptins, lipopeptide natural products, revealed by HDAC inhibition in Aspergillus nidulans.</title>
            <authorList>
                <person name="Henke M.T."/>
                <person name="Soukup A.A."/>
                <person name="Goering A.W."/>
                <person name="McClure R.A."/>
                <person name="Thomson R.J."/>
                <person name="Keller N.P."/>
                <person name="Kelleher N.L."/>
            </authorList>
            <dbReference type="PubMed" id="27310134"/>
            <dbReference type="DOI" id="10.1021/acschembio.6b00398"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2016" name="Angew. Chem. Int. Ed." volume="55" first="1662" last="1665">
            <title>Development of genetic dereplication strains in Aspergillus nidulans results in the discovery of aspercryptin.</title>
            <authorList>
                <person name="Chiang Y.M."/>
                <person name="Ahuja M."/>
                <person name="Oakley C.E."/>
                <person name="Entwistle R."/>
                <person name="Asokan A."/>
                <person name="Zutz C."/>
                <person name="Wang C.C."/>
                <person name="Oakley B.R."/>
            </authorList>
            <dbReference type="PubMed" id="26563584"/>
            <dbReference type="DOI" id="10.1002/anie.201507097"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>PATHWAY</scope>
    </reference>
    <comment type="function">
        <text evidence="3 4 5">Branched-chain-amino-acid aminotransferase; part of the gene cluster that mediates the biosynthesis of aspercryptins, linear lipopeptides built from six amino acids including 2 highly unusual and nonproteogenic amino acids, 2-amino-octanoic acid (2aoa) and 2-amino-dodecanol (2adol) (PubMed:23248299, PubMed:26563584, PubMed:27310134). The core structure of aspercryptins is as follows: Ser/Ala-Thr-Ile/Val-2aoa-Asn-2adol (PubMed:27310134). The first step of aspercryptin biosynthesis is the generation of the fatty acid precursors, octanoic and dodecanoic acids, by the FAS subunits atnF and atnM (PubMed:26563584, PubMed:27310134). The fatty acid precursors are likely transformed into the corresponding alpha-amino fatty acids in three steps (PubMed:26563584, PubMed:27310134). First, they are hydroxylated by the cytochrome P450 monooxygenase atnE, then oxidized to the corresponding alpha-keto acids by the NAD(P)-dependent oxidoreductase atnD, and finally converted to the alpha-amino fatty acids by the PLP-dependent aminotransferases atnH or atnJ (PubMed:26563584, PubMed:27310134). the alpha-amino fatty acids, 2-amino-octanoic and 2-amino-dodecanoic acids, are recognized, activated, and covalently tethered to the NRPS atnA by its fourth and sixth adenylation domains (PubMed:27310134). The second module of atnA is the Thr module and contains an epimerase (E) domain responsible for the epimerization of Thr to D-allo-Thr (PubMed:26563584). Additionally, despite atnA having only one epimerase domain, the first amino acid of aspercryptin A1 is D-Ser, suggesting that serine is either loaded directly as D-Ser on the first module or that the epimerase domain in the threonine module epimerizes both L-Ser and L-Thr (PubMed:27310134). After condensation of the hexapeptide of aspercryptin, the C-terminal reductase (TE) domain might be involved in the reductive release and production of the aldehyde hexapeptide (PubMed:26563584). Further reduction would generate aspercryptins (PubMed:26563584, PubMed:27310134). The variety of aspercryptins produced reflects the flexibility of the atnA NRPS, allowing incorporation of alanine instead of serine, valine for isoleucine, and a C10 fatty amino alcohol instead of the C12 version (PubMed:27310134). AtnB seems to be involved in the selectivity for Ile versus Val by the third module (PubMed:26563584). Moreover, type B, C and D aspercryptins have an additional N-terminal cichorine, acetyl and propionyl group respectively (PubMed:27310134).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="induction">
        <text evidence="5">Expression is positively regulated by the aspercryptin cluser-specific transcription factor atnN (PubMed:27310134).</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="4">Eliminates approximately 40% of aspercryptin production (PubMed:26563584).</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.-" evidence="7"/>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF73440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AACD01000135">
        <property type="protein sequence ID" value="EAA59532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_681147.1">
        <property type="nucleotide sequence ID" value="XM_676055.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AV02"/>
    <dbReference type="SMR" id="Q5AV02"/>
    <dbReference type="STRING" id="227321.Q5AV02"/>
    <dbReference type="EnsemblFungi" id="CBF73440">
        <property type="protein sequence ID" value="CBF73440"/>
        <property type="gene ID" value="ANIA_07878"/>
    </dbReference>
    <dbReference type="GeneID" id="2869297"/>
    <dbReference type="KEGG" id="ani:ANIA_07878"/>
    <dbReference type="eggNOG" id="KOG0975">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031922_0_2_1"/>
    <dbReference type="InParanoid" id="Q5AV02"/>
    <dbReference type="OMA" id="ISIEWTA"/>
    <dbReference type="OrthoDB" id="1732691at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004084">
        <property type="term" value="F:branched-chain-amino-acid transaminase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd01557">
        <property type="entry name" value="BCAT_beta_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.10.10:FF:000004">
        <property type="entry name" value="Branched-chain-amino-acid aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="entry name" value="D-amino Acid Aminotransferase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018300">
        <property type="entry name" value="Aminotrans_IV_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005786">
        <property type="entry name" value="B_amino_transII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033939">
        <property type="entry name" value="BCAT_family"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01123">
        <property type="entry name" value="ilvE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009897">
        <property type="entry name" value="PRK13357.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11825:SF44">
        <property type="entry name" value="BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11825">
        <property type="entry name" value="SUBGROUP IIII AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006468">
        <property type="entry name" value="BCAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="D-aminoacid aminotransferase-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00770">
        <property type="entry name" value="AA_TRANSFER_CLASS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0032">Aminotransferase</keyword>
    <keyword id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000444131" description="Branched-chain-amino-acid aminotransferase atnH">
        <location>
            <begin position="1"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="1">
        <location>
            <position position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P19938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="23248299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="26563584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="27310134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="6">
        <source>
            <dbReference type="PubMed" id="26563584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="7">
        <source>
            <dbReference type="PubMed" id="26563584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBF73440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="396" mass="44244" checksum="48CCE97D80E9D4B6" modified="2005-04-26" version="1">MARLLNRWHLPALVRRHYSSRFQSLRIEKTQSPKPLPDSTELQFGRSFTGKYPSQTRNHILKLEWTTTQGWSDAQITPYDNLRLDPASCVLHYAFTCFEGMKAYKDPHGNARLFRPEENLARLNRSAARLALPTFEESGVLEFLAKYVDLEKRFIPHLPGHSLYLRPTLLGTDASISVSRPRSALLFVIASPMGDYFANGMKAVTLQATRSPVRAWPGGVGEFKVGGNYAPSIVPQEEAAEAGSQQNLWLLADRESGEEFVTEAGTMNLFVVWVSSSTGKKELVTPPLDGTILPGVTRMSILELARERLEGDRSGIEVVERRITMRELAAASKEGRLLEVFGAGTAVVVSPVRSIRWGDQCISCGLRDGEEAGPMSLQMKTWLEEVQYGLVEHPWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="119" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AVH4</accession>
    <accession>C8VDG9</accession>
    <name>Q5AVH4_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNA binding protein, putative (AFU_orthologue AFUA_5G08310)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ANIA_07706</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF79945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_680975.1">
        <property type="nucleotide sequence ID" value="XM_675883.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AVH4"/>
    <dbReference type="FunCoup" id="Q5AVH4">
        <property type="interactions" value="999"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5AVH4"/>
    <dbReference type="GeneID" id="2869696"/>
    <dbReference type="KEGG" id="ani:ANIA_07706"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN7706"/>
    <dbReference type="eggNOG" id="KOG0533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052367_4_0_1"/>
    <dbReference type="InParanoid" id="Q5AVH4"/>
    <dbReference type="OMA" id="RNDYPRD"/>
    <dbReference type="OrthoDB" id="5382468at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd12418">
        <property type="entry name" value="RRM_Aly_REF_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051229">
        <property type="entry name" value="ALYREF_mRNA_export"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025715">
        <property type="entry name" value="FoP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19965">
        <property type="entry name" value="RNA AND EXPORT FACTOR BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19965:SF82">
        <property type="entry name" value="THO COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13865">
        <property type="entry name" value="FoP_duplication"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01218">
        <property type="entry name" value="FoP_duplication"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="86"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="51"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="156"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="16"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="51"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="165"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="222"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="284"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBF79945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="328" mass="36307" checksum="A7F98A198B466180" modified="2005-04-26" version="1">MDRSLDEIIAERPQRQNRGQNRGPRNQGRRSNGVKKPYRDERVDLDLDWVHDKYEDDRDTRPSRGGRRPRVDRYSPSPDRSASAGTRLRIENLHYDITETDLEELFSRIGPISNVSLVYDRAGRSEGVAYVTYSRYNDAKTAIAEFDGANAKGQPIRISITSSGPRRDRNPFDTAEKPRGSLFDRVERPRDARSLSPESRSESAEGAGRRRRRRGGGGGNYRRSDVSKPAPDHIDRYIPGQQAPARRAGGGRRQGGDGRRGNPRPKKTQEELDQEMEDYWGSNAAAETAEQAAAPEQTAAEPAPAASAVAAPAAAAAPAADDDIDMIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AVU4</accession>
    <accession>C8VBS5</accession>
    <name>Q5AVU4_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ANIA_07586</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF79681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_680855.1">
        <property type="nucleotide sequence ID" value="XM_675763.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AVU4"/>
    <dbReference type="GeneID" id="2869422"/>
    <dbReference type="KEGG" id="ani:ANIA_07586"/>
    <dbReference type="HOGENOM" id="CLU_3207614_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AVU4"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF79681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="45" mass="4892" checksum="7C895A518D046B05" modified="2005-04-26" version="1">METAGCQRLAHPCHVIAGPLSNPMLSDHRQEIRGLLTGHQQTDDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="120" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AVW4</accession>
    <accession>C8VBQ3</accession>
    <name>Q5AVW4_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Exonuclease, putative (AFU_orthologue AFUA_2G14950)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ANIA_07566</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the REXO1/REXO3 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF79641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_680835.1">
        <property type="nucleotide sequence ID" value="XM_675743.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AVW4"/>
    <dbReference type="FunCoup" id="Q5AVW4">
        <property type="interactions" value="214"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5AVW4"/>
    <dbReference type="GeneID" id="2869567"/>
    <dbReference type="KEGG" id="ani:ANIA_07566"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN7566"/>
    <dbReference type="eggNOG" id="KOG2248">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008679_1_0_1"/>
    <dbReference type="InParanoid" id="Q5AVW4"/>
    <dbReference type="OMA" id="CGFMTVK"/>
    <dbReference type="OrthoDB" id="206335at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031125">
        <property type="term" value="P:rRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd06145">
        <property type="entry name" value="REX1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000019">
        <property type="entry name" value="RNA exonuclease NEF-sp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034922">
        <property type="entry name" value="REX1-like_exo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047021">
        <property type="entry name" value="REXO1/3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801:SF115">
        <property type="entry name" value="FI18136P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801">
        <property type="entry name" value="RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="8">
        <location>
            <begin position="344"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="243"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="31"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBF79641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="723" mass="78994" checksum="371F65766A64380D" modified="2005-04-26" version="1">MPKRKHTDYGYSDDAAPVMADPGSQGFGLGQTLSMLSKSTEPATDASTGSTAQPASGGSPDDADNGPDGARPSKKKRLNGEKIKYPTLTYVEGRTLQSSIRIADLQNLLLFCFADGVAPQWIAVKNTTRIRKAVFLMVPGLELGMLNGKVPLDGSEVKEVKGADAEDGTEDTRAAEFARWKEGLPPQDRSHLFSPRPLSRDNVPEPLQPLADVFPHAWPVRAPGDSKYNKVHSPLQAVLLTSVPKEKEKKTKGPKPPRVDKNYTSKRTPITAFISGADELRENDYPLHPALCASEDEKLALKNARKRAGQSAEDGWVDTHVESLEEGNVPEAEIQQGSMTAGRDVLALDCEMCITEGGSSELTRISLVRWDGEVVLDELVKPRLPVIDYLTRFSGITKEMLDPVTTTLRDIQQKLLNIITPRSILVGHSLNSDLNALKLTHPFIVDTVFLYPHPRGPPLRASLKWLTQKYLGKEIQKGTTGHDSIEDARAVLELVKQKCEKGEQWGTSDASNESIFKRLSRHSAPGKPNVAAGGTGRTGAVVDWGNPERGLGAQATVAIGCSDDEAVVKGIQAAVNGDESKPSIPGGGVDFTWARMRELEIYRGWCNRIPDPSNANTSTLIAFDSSSSSSESRTLPTVVSQTVSRIKEVYDALPACTLFVVYSGTGDPREVSRLQAMHKIFRDEYQSKKPWDELSVKWTDTEEQALKKACERAREGCAFMCVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AWL4</accession>
    <accession>C8VCN7</accession>
    <name>Q5AWL4_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ANIA_07316</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-beta-lactamase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF78631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_680585.1">
        <property type="nucleotide sequence ID" value="XM_675493.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AWL4"/>
    <dbReference type="STRING" id="227321.Q5AWL4"/>
    <dbReference type="GeneID" id="2869849"/>
    <dbReference type="KEGG" id="ani:ANIA_07316"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN7316"/>
    <dbReference type="eggNOG" id="ENOG502SIPA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030571_3_2_1"/>
    <dbReference type="InParanoid" id="Q5AWL4"/>
    <dbReference type="OMA" id="MYCILID"/>
    <dbReference type="OrthoDB" id="10250730at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07729">
        <property type="entry name" value="AHL_lactonase_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051013">
        <property type="entry name" value="MBL_superfamily_lactonases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42978:SF2">
        <property type="entry name" value="102 KBASES UNSTABLE REGION: FROM 1 TO 119443"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42978">
        <property type="entry name" value="QUORUM-QUENCHING LACTONASE YTNP-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="6">
        <location>
            <begin position="66"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBF78631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="294" mass="33194" checksum="D8D72C0B4250984F" modified="2005-04-26" version="1">MSAIQTQIQNGAVPNAVSNVCPPGTKFHVLEVGWLECDEAFVTRGGNTSTKSTEGKSFVNKRRQLPMYCILIEHPHEGLILWETGCGKDYPEVWGPAVSDIFARVRYEPQHELRAAIEATGNKVEDVKKIIIGHLHLDHAGGLDEFMENKEVEVWVHERELNAAFWSVATGADAGVYLAHYLNLSLNWKTFNDQTMDFCQGITLHHLPGHTDGLIGMQINMPESGTFFFISDHCHVLENWIDGIPQGWLARDHPAWFRSTQRLKQLQRITKGQVIPGHDETTFLELKKQAKVFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="128" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AXC4</accession>
    <accession>C8VB47</accession>
    <name>Q5AXC4_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ANIA_07056</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF79175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_664660.1">
        <property type="nucleotide sequence ID" value="XM_659568.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AXC4"/>
    <dbReference type="STRING" id="227321.Q5AXC4"/>
    <dbReference type="GeneID" id="2870198"/>
    <dbReference type="KEGG" id="ani:ANIA_07056"/>
    <dbReference type="eggNOG" id="KOG1238">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_540816_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AXC4"/>
    <dbReference type="OMA" id="EHKSAIG"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-dep_OxRdtase_2_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF138">
        <property type="entry name" value="DEHYDROGENASE PKFF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030175741" description="Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein" evidence="5">
        <location>
            <begin position="24"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-dependent oxidoreductase 2 FAD-binding" evidence="7">
        <location>
            <begin position="28"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="6">
        <location>
            <begin position="116"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase C-terminal" evidence="8">
        <location>
            <begin position="289"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBF79175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="504" mass="54885" checksum="F4A60164C583297F" modified="2005-04-26" version="1">MNISISKFASFLIATDLLGGAFQAETFDYVVVGGGTAGVTLAVRLAEASHSVALIEAGTYYEDSWPFAAIPGADVIPVGSDPDAKFGADWGFVTAPQAGADGRRIHFARGKCVGDLHTQRLAKRILFDEHKSAIGVEVANGFGYLSNITASREVIISAGAFQYPQLLMVSGIGPAEQLAKHGIEVISDLQVGQNMWDHPFFALSYRVNVETLTRAANDLLYLGTTFLDYTTKHTGPLTNPVADFIAFEKIPSSHRTAFSAETEKHLAGFPEDWPEVETEAIQYMSGAGYFRPPVINPNWLATEADQEAAIAIFKCIRDIFASDGMAPVILGDEYYPGNGTQADAEILRFIQKNVMTLWHPSCTNKMGTKDDPSAVLDSKARVFGVGGLRVANASSFPFLPPGHPQSTVFKQLYYCFYTAVGNLGGLNIYNRSMNPFLGCGMRKASNYNINLPKDSSSAARSYSFEWARAIFFLEQACQIMAQKYRIAYLMTLFNTASRGRLGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="102" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AXF3</accession>
    <accession>C8VB78</accession>
    <name>Q5AXF3_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter, putative (AFU_orthologue AFUA_4G04250)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ANIA_07027</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF79229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_664631.1">
        <property type="nucleotide sequence ID" value="XM_659539.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AXF3"/>
    <dbReference type="GeneID" id="2870101"/>
    <dbReference type="KEGG" id="ani:ANIA_07027"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_0_1_1"/>
    <dbReference type="InParanoid" id="Q5AXF3"/>
    <dbReference type="OMA" id="TFWYRNS"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000057">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF49">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G04250)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="209"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="319"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="351"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="383"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="415"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="44"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBF79229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="455" mass="49656" checksum="6B292E2B8427BA7A" modified="2005-04-26" version="1">MEKEVAPDGVVNATDAELVIQNSGGDAAVQAREKALIWKQDLHIIPLSAAIYLLCYLDRSNIGNAKIMNSETGNDLLTETNMSSYEYTIALMVFLIAYALFEVPSNYFLKKLKPSRWIAFLMLSWGAVTMGLGGAHNYAQVTGLRFLLGVLEAGLFPGLVYFLTFWYRTSERSMRVALILASATLAGAFGGAIAYGVGHMNQAQGLSAWRWLFIIEGAPSLASAFLVWFILPDYPESASWLSEEEKALAAQRLAVEGSKGGAKAMTWQDAKEILLDWRLYAHYVVYFGISAPFSSLSLFTPAITSGLGYTSLNAQLMTVPPWAVAYVVTTAVAWSADHFNRYPRISLHRYGCLIVATSGSFACIPPLLGWLSSNIRSTAGTGLAIALNVSFGAPGQIVGVWIYKSNEAKRGYPTGHWTNAALLLLVTVGCLALRVYYGWRNKRLKAGGSGQRFAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="105" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AXN5</accession>
    <accession>C8V379</accession>
    <name>Q5AXN5_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">O-methyltransferase, putative (AFU_orthologue AFUA_8G00390)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ANIA_06945</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
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        <property type="protein sequence ID" value="CBF71797.1"/>
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    <dbReference type="KEGG" id="ani:ANIA_06945"/>
    <dbReference type="eggNOG" id="KOG3178">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_005533_5_0_1"/>
    <dbReference type="InParanoid" id="Q5AXN5"/>
    <dbReference type="OMA" id="KQFNNHM"/>
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        <property type="component" value="Chromosome I"/>
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        <property type="evidence" value="ECO:0007669"/>
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        <property type="term" value="F:protein dimerization activity"/>
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        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
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    </dbReference>
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        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:secondary metabolite biosynthetic process"/>
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        <property type="project" value="GO_Central"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="COMT_dimerisation"/>
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        <property type="entry name" value="SAM-dependent_MTases_sf"/>
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        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF1">
        <property type="entry name" value="HYPOTHETICAL O-METHYLTRANSFERASE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08100">
        <property type="entry name" value="Dimerisation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase dimerisation" evidence="5">
        <location>
            <begin position="96"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="4">
        <location>
            <begin position="272"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBF71797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="434" mass="48168" checksum="6B4F5DCBC2A79C04" modified="2005-04-26" version="1">MPHTENTTNACANGHGNGYNENGITVNVEELAVSPNLPDQVPGLLDKIAAFSKQYLGAEPQARLKLLETARSLVYALETPREAIIRHCWAESTSYAALETAVALNLFTALGTHESKTVAELAEATGAEPALLSQLETGRLMKHLAAMGVITETGCDEYRPTSFSKVLTVEKYSDAFPLMTSRFTMGILALPAFLEKTKYRNPTSATDTAFQLGYNTDKGFFGLLQQEPITAKRFNNHMGVYAQGRARWMDPGFYPVRERLIDGVAINQEDVLLVDVGGSFGHDLLDFRRKWPDIPGRLVLQDLPEVISAVKDLHPSIDITAHDFFTEQPVKAARAYYLHSVLHDWPDDLCSKILANLAAAMKPRYSKLLVNENVIPDKGAYWETTSLDLIMMQLGSGERTERHWRSLLESAGLRIVGFWTAHRSVESLIECELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AXU8</accession>
    <accession>C8V2R0</accession>
    <name>Q5AXU8_EMENI</name>
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        <submittedName>
            <fullName evidence="1">Carboxyvinyl-carboxyphosphonate phosphorylmutase (AFU_orthologue AFUA_2G00120)</fullName>
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        <name evidence="1" type="ORF">ANIA_06882</name>
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    <organism evidence="1 2">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
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        <lineage>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
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            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF71655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
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        <property type="component" value="Chromosome I"/>
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    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
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        <property type="project" value="GO_Central"/>
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    <dbReference type="CDD" id="cd00377">
        <property type="entry name" value="ICL_PEPM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039556">
        <property type="entry name" value="ICL/PEPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42905:SF13">
        <property type="entry name" value="CARBOXYVINYL-CARBOXYPHOSPHONATE PHOSPHORYLMUTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42905">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13714">
        <property type="entry name" value="PEP_mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF71655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="334" mass="36528" checksum="09C5E383B11FB19F" modified="2005-04-26" version="1">MPVPYPFKFTTPDQPTSSCNGEITSLTIQLENVRGRIPSAQASRLRTMMLEAHNDPSKIIAHACSYDGLSSRLVEEAGFPIVFLAGYTVASSFGLPDTGYIAMEDQCKRIQEVVRLVKVPVMADGDTGYGGPMNVKRTVESFAAAGAAGIMIEDQTWPKRCGHTKGKSVVTRGEAYARIQAAVDARNEGQDIFILARTDALIHGWDEALTRAKEFKRIGVDAVFVEALPDRESMRRCVQDVGIPTFANIIEGGKTENISAKNLAELGFCAVAYPWTLVAARLKSIRETLDALKKSMTEGAPPMILSYAEVCEGVGFNKYWVELEKQQEAGDLIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AY57</accession>
    <accession>C8V262</accession>
    <name>Q5AY57_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">LIP-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_06773</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF71430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_664377.1">
        <property type="nucleotide sequence ID" value="XM_659285.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AY57"/>
    <dbReference type="ESTHER" id="emeni-q5ay57">
        <property type="family name" value="Fungal-Bact_LIP"/>
    </dbReference>
    <dbReference type="GeneID" id="2870303"/>
    <dbReference type="KEGG" id="ani:ANIA_06773"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN6773"/>
    <dbReference type="eggNOG" id="ENOG502SHJQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029538_5_0_1"/>
    <dbReference type="InParanoid" id="Q5AY57"/>
    <dbReference type="OMA" id="HATTEII"/>
    <dbReference type="OrthoDB" id="2373480at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005152">
        <property type="entry name" value="Lipase_secreted"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34853">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34853:SF5">
        <property type="entry name" value="LIP-DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03583">
        <property type="entry name" value="LIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029171">
        <property type="entry name" value="Esterase_LipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013437485" description="LIP-domain-containing protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR029171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF71430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="448" mass="48738" checksum="9614BFB20594B8FA" modified="2005-04-26" version="1">MYSPLWHLLWSLAVSLSLDVAQSIPAAQDPRTDPFYQPPPGFERAPPGTIFRKRLVTTSFFGLVPDPVEAHQLLYRTTAINGSAIASITTVFKPLHAITDRYVSFHTAYDSASVTCDPSYQYQLGVPQTDLISTFEFLFLQRHLLHGYIVASPDHEGPDAALGSGRLAGMTVLDGMRAVNNFNETLGFSTSRPMIAATGYSGGAIATGWAASLHYVYAPELNVKGWAMGGTPANLTGTFYYLDGKLYSGFIPAAVNGLSKPSAYGTQLLPIIDRIVTEKGRALLDYANSHCVPADLANWPNQSMLSPDIQTLGPTLLLEPTIHSVLLENLLGGRPEEAPMAPVLVYHSVEDEIIPYHDIPLMVDSWCSAGATVQFRTYVTGGHARTLLGSLTDSAGYIDDAFAGTLEHGCSWQFRTISPHPVIGKVDHEHIFSQLSENLNQLFWAEAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AYD4</accession>
    <accession>C8V1N1</accession>
    <name>Q5AYD4_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcription factor Tos4, putative (AFU_orthologue AFUA_7G05440)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_06696</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF71266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_664300.1">
        <property type="nucleotide sequence ID" value="XM_659208.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AYD4"/>
    <dbReference type="FunCoup" id="Q5AYD4">
        <property type="interactions" value="413"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5AYD4"/>
    <dbReference type="GeneID" id="2870487"/>
    <dbReference type="KEGG" id="ani:ANIA_06696"/>
    <dbReference type="eggNOG" id="ENOG502RZJP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027207_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AYD4"/>
    <dbReference type="OMA" id="RDRVEIM"/>
    <dbReference type="OrthoDB" id="5348546at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="CDD" id="cd22699">
        <property type="entry name" value="FHA_PLM2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="2">
        <location>
            <begin position="106"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="344"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="52"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="239"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="292"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF71266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="510" mass="56819" checksum="780D99A3C5D0E247" modified="2005-04-26" version="1">MESSPPRSCSVAPVAGVKRPASLLPAFEPLSSSPSLPRPQKRVARDDDRAISTYPTPVPTSSTHIMSSSPPRMPTSSRRNLTSTLSERAPLSTVPTLMLPETGEPIMMGRSSLSCQYQLAANRMISRVHVKATYKPAPNPFDRDRVEIMCLGWNGLKLHCQGKTYTLAKGKTFTSDIKDADIMIDVSESRVLVQWPRGDRKEDVSTDSEQTWEETTPTRKKQTHRSLQDSPGAERQRLASPVSPSPAVKSMIPPSSPLFTPTRSRNAVVVYEDEASPVRLLHSDDALKPSSSVASLLQSSQSSDLSDLSKPDDLSDHDEENDPIIHSFGPFGDNLLPRMASFSADESPLRPTRPRAHLQPTSPKQPSKPVEHSQEEEEKKKKKKTAVINEDAEHVQNHAVNQLAFSRLSSTPFSTILDNLPSSIWKADNHSRHGPSREEIRVILDSTKCIGKVAREGKDAAGKPLEAEYYYIPDFDDDVMRREAVVTDLRKPGLRNCRKQHKQYFWRKPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="102" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AYS9</accession>
    <accession>C8V0T4</accession>
    <name>Q5AYS9_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HATPase_c domain protein, putative (AFU_orthologue AFUA_6G04830)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_06551</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF70970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_664155.1">
        <property type="nucleotide sequence ID" value="XM_659063.1"/>
    </dbReference>
    <dbReference type="GeneID" id="2870277"/>
    <dbReference type="KEGG" id="ani:ANIA_06551"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN6551"/>
    <dbReference type="eggNOG" id="ENOG502QPMA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001744_1_0_1"/>
    <dbReference type="InParanoid" id="Q5AYS9"/>
    <dbReference type="OMA" id="VYWWVIL"/>
    <dbReference type="OrthoDB" id="10031156at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022155">
        <property type="entry name" value="DUF3684"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058210">
        <property type="entry name" value="SACS/Nov_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF047352">
        <property type="entry name" value="P_loop_sacsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47839">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G04830)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47839:SF1">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G04830)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12449">
        <property type="entry name" value="DUF3684"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25794">
        <property type="entry name" value="SACS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sacsin/Nov" evidence="2">
        <location>
            <begin position="32"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1439"/>
            <end position="1528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1480"/>
            <end position="1497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1507"/>
            <end position="1517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF70970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="1734" mass="193704" checksum="4DF0532956DCAA81" modified="2005-04-26" version="1">MTQNVDFSALKARTMRSGEDEEAVTVDTRGLISKVLARYSGQWTVLREMIQNAADANATKVTIKFETLPSKTVPFPSTTDRTSLIKHTISHHTIKRLLISNNGLLFNEKDWARLKRIADGNPDETKIGAFGVGFYSVFEDCEEPFVSSGSDAMAFYWKENALFTRRLQLNEQANSETTFVLDYRNDTSPIPSLMQLCQFLSSSLTFVNLECIELWLDDWNILRLAKKAAPGIALALPKDIETKTQEGLMKITSVTREVAQVDAAWMQVVEWNPNSSTLVEGIRDTTSSLRSFLSRLTQGSSSKVADTQKKEAADDTGDLTKISTATIFLHINTGSIQASISQSLGSELERATRKPPPKKTSIAVLTPSYDTSLASSSSQAEFLSTILPSKGGRVFIGFPTQQTTGLNAHISAPSVIPTVERESIDLNSRYIRKWNTEMLRAAGIICRIAWSAEMASVKNRIISGKDPSKQSKIRKADITTVLPEAIHTANQFVFRESTPLSVLGQIIEDAFWTCNKNASIEVISTCGVVHNHQARIATKDLTFLDSIPVLPDEFVEGSKEFVKKLTLLGLVTEVTVTDIKRELETCPLRSSQITEFLSWLARRTVSGQLDSYSARSILNVAVASADENDTDTGLIVFSGVSLFLNPQRIPADLPLPPAVMPFKYTKSLSKKDLESFGWEELQIVPWLCWLVSNAGNRDVLPQTQDITKCPSFAAQVLPVISKQWETLGQSSKQDVIDQLQAHTVIPTKIGMKCPTEAYFSSVRLFDDLPVVHGLQGVKEKLLTALGVRKTVELGVIFERLLNAPGSSDGDKSSQGKWSHVDLIRYLASVSSDIPASDIKRLKDTNFCTAEPIIDHDGSRRPNEDRYKVQQLYEPNDALRALRLPILEWPAKFTSSSPEGRFLARLGLRTFPQSTVLTRIMAAAAEHNDWALHGKAMSYYVTEFENNGYGAIDCGSINDEFLPVEQINDSGAEKRYKVSAPSKCFTDEGAALFGYDILRKDLHRHASKLGVQRHPKLSNCLDTLIRLPPSTVREARSLYRYLAGRVSELTPRDIDRVGRAEIVPVFAENNKGSTMHRVAPSLCYLGEGEDYKDIFDFVDFGQEANLFLMAVGSKREPTKIELAQMIVREPARISSTFQSGEKYLKLLRTLAEDMSLLRKNKELWQEMKRSAFLLASKDITSTAQVGDGAKKIVDNSDDEDEAEDGGIREWALTMAKETIVVDDYQSFILFKDHVLAGKPAPQEEILENFYLALGALPLSQLVEERANWGAPATDQRLAVKLLKLIKERSRLFLHDQPADSIRHDSRWLDKNLNVQVVQSITLTRSLRNRGISYRQERKAIVTEVSRECIMRICPEKYDFYEISQALSSLILARPKLHSALTLEMLLKTDLLELRGRGYNVDRILKQKAHDAQIAETRRQQQLEEERRRLREKELALAEEARDQIAETQDATSMPGVFPDSPSSKDVRPNSPTQSPKEKRNLFSTFTKHFSEGNRSSWNPFRGETASLPDPPRASPPQLPTEQVKPPRPEAPVAVNSALQLQKSLHSAIQSSRSHGASGVFSRPQVDRINELKSYCDEKPGHDLEFAATLPCGVNILVARSVERSAFLTKNSVGLNLFGSILLDCADVFALRPDTVSIFYDPGSKAIGFNRSGSIFCNYHYFQQLHEKALLQKPTPDRAEAMVYWWVTLSHELAHNLVADHSSAHSYYTESFVSQYFTRIAAKIAHAATKRPNPEQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2010-05-18" modified="2026-01-28" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AZ85</accession>
    <accession>C8V0P1</accession>
    <accession>Q1HFS3</accession>
    <name>RGLB_EMENI</name>
    <protein>
        <recommendedName>
            <fullName>Rhamnogalacturonate lyase B</fullName>
            <ecNumber>4.2.2.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">rglB</name>
        <name type="ORF">AN6395</name>
    </gene>
    <organism>
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="11417" last="11422">
            <title>Development and application of a suite of polysaccharide-degrading enzymes for analyzing plant cell walls.</title>
            <authorList>
                <person name="Bauer S."/>
                <person name="Vasu P."/>
                <person name="Persson S."/>
                <person name="Mort A.J."/>
                <person name="Somerville C.R."/>
            </authorList>
            <dbReference type="PubMed" id="16844780"/>
            <dbReference type="DOI" id="10.1073/pnas.0604632103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA]</scope>
        <scope>FUNCTION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Pectinolytic enzymes consist of four classes of enzymes: pectin lyase, polygalacturonase, pectin methylesterase and rhamnogalacturonase. Degrades the rhamnogalacturonan I (RG-I) backbone of pectin. Active against linseed rhamnogalacturonan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>Endotype eliminative cleavage of L-alpha-rhamnopyranosyl-(1-&gt;4)-alpha-D-galactopyranosyluronic acid bonds of rhamnogalacturonan I domains in ramified hairy regions of pectin leaving L-rhamnopyranose at the reducing end and 4-deoxy-4,5-unsaturated D-galactopyranosyluronic acid at the non-reducing end.</text>
            <dbReference type="EC" id="4.2.2.23"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the polysaccharide lyase 4 family.</text>
    </comment>
    <comment type="sequence caution" evidence="5">
        <conflict type="erroneous gene model prediction">
            <sequence resource="EMBL-CDS" id="CBF69554" version="1"/>
        </conflict>
    </comment>
    <comment type="sequence caution" evidence="5">
        <conflict type="erroneous gene model prediction">
            <sequence resource="EMBL-CDS" id="EAA58417" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EC" id="4.2.2.23"/>
    <dbReference type="EMBL" id="DQ490501">
        <property type="protein sequence ID" value="ABF50877.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AACD01000108">
        <property type="protein sequence ID" value="EAA58417.1"/>
        <property type="status" value="ALT_SEQ"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF69554.1"/>
        <property type="status" value="ALT_SEQ"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_663999.1">
        <property type="nucleotide sequence ID" value="XM_658907.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AZ85"/>
    <dbReference type="SMR" id="Q5AZ85"/>
    <dbReference type="STRING" id="227321.Q5AZ85"/>
    <dbReference type="CAZy" id="PL4">
        <property type="family name" value="Polysaccharide Lyase Family 4"/>
    </dbReference>
    <dbReference type="GlyCosmos" id="Q5AZ85">
        <property type="glycosylation" value="7 sites, No reported glycans"/>
    </dbReference>
    <dbReference type="GeneID" id="2871281"/>
    <dbReference type="KEGG" id="ani:ANIA_06395"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN6395"/>
    <dbReference type="eggNOG" id="ENOG502QQM5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016624_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AZ85"/>
    <dbReference type="OrthoDB" id="2130367at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016837">
        <property type="term" value="F:carbon-oxygen lyase activity, acting on polysaccharides"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102210">
        <property type="term" value="F:rhamnogalacturonan endolyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="CDD" id="cd10317">
        <property type="entry name" value="RGL4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10316">
        <property type="entry name" value="RGL4_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10320">
        <property type="entry name" value="RGL4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1120">
        <property type="entry name" value="Carboxypeptidase-like, regulatory domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051850">
        <property type="entry name" value="Polysacch_Lyase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029413">
        <property type="entry name" value="RG-lyase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029411">
        <property type="entry name" value="RG-lyase_III"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32018:SF9">
        <property type="entry name" value="RHAMNOGALACTURONATE LYASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32018">
        <property type="entry name" value="RHAMNOGALACTURONATE LYASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14683">
        <property type="entry name" value="CBM-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14686">
        <property type="entry name" value="fn3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="Starch-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0624">Polysaccharide degradation</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000394378" description="Rhamnogalacturonate lyase B">
        <location>
            <begin position="19"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="446"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="453"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="25"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="284"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="524"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="566"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="16844780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <sequence length="660" mass="73509" checksum="D2629EAE80E2DAB6" modified="2010-05-18" version="2" precursor="true">MRLGVCFSLAAAASVARAALTATENDTSIVLENDRLRATFDKGRGSIIDLYLDGQDFLGPQSGSTGIGPYLDCYCTPSGFYTAGSTNPVTELVQGTDSTGTKYAGIILNDTYTPTGQEFQQYWFLRDGETGFHMFSRLAYYNETTPFLRNLQELRTLFRPNTDLWTHLTSSDLQTAPLPSDEAIAEQIVVQDATWRLNNTPDDAYYQQFSEYFTKYTFSNHWRDNDVHGLYADGSTSDGTTYGAWLVMNTKDTYYGGPLHSDLTVDGIIYNYIVSNHHGEGTPNITNGFDRTFGPQFYLFNGGGSSSLEELRDEARSLASPSWNADFYDSIAKHVIGYVPSSQRGSVKGTIKLPKNAKSPIAVLTVDGHYFQDNSAVPSSHQYWADIDKNGRFSIDRVVAGKYRLTVYADGIFGDFTRDGIVVKARKSTSIKETWKPESAGTEIWRLGTPDKSSGEFRHGAARDPTHPRHPPEYLIYWGAYDWQSDFPGGIDYMIGESDPATDFNTVHWAVFGPTPDNPVAESNTTHDWRIRFDLSAKQLHARKTATLTIQLAGAKAASGNTDVYNASEPYANLPLRSYINEQEEPLTMVIGYDQSSSCIVRSAVSCYQVREKWEFPASWLKEGSNLLRLSLPTNGTNYESAVLPTSVYVQYDALRLELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="136" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B055</accession>
    <accession>C8V2S7</accession>
    <name>Q5B055_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phenylalanine ammonia-lyase (AFU_orthologue AFUA_2G09110)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_06075</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the PAL/histidase family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF70237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_663679.1">
        <property type="nucleotide sequence ID" value="XM_658587.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B055"/>
    <dbReference type="STRING" id="227321.Q5B055"/>
    <dbReference type="GeneID" id="2871022"/>
    <dbReference type="KEGG" id="ani:ANIA_06075"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN6075"/>
    <dbReference type="eggNOG" id="KOG0222">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014801_3_1_1"/>
    <dbReference type="InParanoid" id="Q5B055"/>
    <dbReference type="OMA" id="GNFHGDY"/>
    <dbReference type="OrthoDB" id="10051290at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016841">
        <property type="term" value="F:ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00332">
        <property type="entry name" value="PAL-HAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.200.10">
        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="entry name" value="Fumarase/aspartase (N-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.20">
        <property type="entry name" value="Phenylalanine ammonia-lyase 1, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001106">
        <property type="entry name" value="Aromatic_Lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022313">
        <property type="entry name" value="Phe/His_NH3-lyase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005922">
        <property type="entry name" value="Phe_NH3-lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023144">
        <property type="entry name" value="Phe_NH3-lyase_shielding_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01226">
        <property type="entry name" value="phe_am_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10362">
        <property type="entry name" value="HISTIDINE AMMONIA-LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00221">
        <property type="entry name" value="Lyase_aromatic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00488">
        <property type="entry name" value="PAL_HISTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF70237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="701" mass="76825" checksum="17AF31B57EDED820" modified="2005-04-26" version="1">MLVRSHLDMKAEALQPHLNTTIQAWYRVQNLVKYGEIEIDGNRLDIPGVVAVACHNCIPKITEDPAVLENIDASIRLLKDRLNQGYSVYGVNTGFGGSADSRTDKMTALQSALLQLTQAGVLLESDKSGNQNKLLESHAMPASWVRGTMLARCNSNLRGHSAVKLSILQSIVKLLQHRITPIVPLRGSISASGDLMPLSYIAGAIEGNPDVYVQVDGLDMPRIMKSIEGLQYAGLEAQKLGPKEGLGLINGTSTSAAVASLVLYETNQLSVLVQALSAMGLEALTGTAESYHPFISAVRPHDGQVECANNLLSLLRGSKLVQGLDGQKFQDRPGLIQDRYALRCVPQWVGPQLEDLLLAHRQVTTELNSTCDNPLVDVKSKSIYSGGNFQAVSITSAMEKTRQCLQMFGRLIFSQATEMIDPSINNGLPTNLVADDPSLSFTMKGVDISMASYMAELGYLSNPVSSHVQSAEMRNQAINSMALVSARYSMQAVEVLSLMCACDVYICCQALDLRVLHNTFLEKAIPQLHSVTERVLSPFLPQPALEDLNRSLDQHLTQTWPMTNRLSPADRVHTVIEKAIPVLLENLKSHRGPSLGDLETWKSQARNLLNVVYQEIAESFFVKPHTADYLGEGAKALYVMVRQELGIPFHQGFIEHPTVENEILNGRPKKTTGSWISIIYEAIRDSRLMGPLIQALTPTDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B0I5</accession>
    <accession>C8V3H4</accession>
    <name>Q5B0I5_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_05945</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF70512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_663549.1">
        <property type="nucleotide sequence ID" value="XM_658457.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B0I5"/>
    <dbReference type="GeneID" id="2870826"/>
    <dbReference type="KEGG" id="ani:ANIA_05945"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN5945"/>
    <dbReference type="HOGENOM" id="CLU_612644_0_0_1"/>
    <dbReference type="InParanoid" id="Q5B0I5"/>
    <dbReference type="OMA" id="QHDAPKL"/>
    <dbReference type="OrthoDB" id="4475110at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF70512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="467" mass="53704" checksum="2C2913B758895672" modified="2005-04-26" version="1">MAIRLPLKIYTCIFKHLLADERDGRKHAFKLRLVSKTIRAIIDPLLDRQLGSPSDRAVEILCHRMIAQPGLGARVEQICLEEDEGAENSEDEFEDEFEDEFEDEDEDEDEEEDESEDEDEDDPGSDSNLKAEARRKAKRDRDVIIAAAEAIKRAFESDPASRYSQALEKNDLNWLTRSTLKTRKWILLFQLSNLKSLALTARTDKFTNMALFLRLPYLEELDFAVLAPGVDSDAHRAIDYVPPIEILETIISSTSRLRSLRFEDMSGTGFRPVLHDAPKLKRILEQHAAATLTYLSICLTNNDEKDWRKEQEFSNIKGYFGSMKSFTRLQGLVMQLEVLLGTPSDGLQLKDVLPTQLQYFTGLNLPDLHGAEDSDRLWEDNDYLLQFQDLAEAARDGQHLPWLKSVKMHLKRKDYFSVYDNWPKKGQFTDFFLCEHDPRIDFRLLAESRIYFGWVSGPYADDGPGPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="134" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B0U1</accession>
    <accession>C8V021</accession>
    <name>Q5B0U1_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">ANIA_05839</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="16">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Plastid</location>
            <location evidence="1">Chloroplast</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
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        <property type="protein sequence ID" value="CBF70735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="XP_663443.1">
        <property type="nucleotide sequence ID" value="XM_658351.1"/>
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    <dbReference type="GeneID" id="2870747"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="InParanoid" id="Q5B0U1"/>
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        <property type="component" value="Chromosome I"/>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0000318"/>
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        <property type="term" value="F:hydrolase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="evidence" value="ECO:0000318"/>
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        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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        <property type="entry name" value="DEXHc_RHA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ATP dependent RNA helicase, putative"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="3.40.50.300:FF:000500">
        <property type="entry name" value="ATP-dependent RNA helicase DHX29"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Putative ATP-dependent RNA helicase DHX36"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
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        <property type="entry name" value="Helicase-assoc_dom"/>
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        <property type="entry name" value="Helicase_ATP-bd"/>
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        <property type="entry name" value="Helicase_C-like"/>
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        <property type="entry name" value="P-loop_NTPase"/>
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    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR18934:SF145">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX57-RELATED"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
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    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
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    <dbReference type="SMART" id="SM00847">
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        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF52540">
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    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
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    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0934">Plastid</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="655"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="901"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
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            <begin position="228"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="377"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="848"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="31"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="55"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="235"/>
            <end position="252"/>
        </location>
    </feature>
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            <begin position="377"/>
            <end position="389"/>
        </location>
    </feature>
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            <begin position="855"/>
            <end position="865"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
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            <dbReference type="ARBA" id="ARBA00022640"/>
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            <dbReference type="ARBA" id="ARBA00022801"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00047984"/>
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    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
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            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS51194"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="CBF70735.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="1436" mass="162188" checksum="B528B249601813AD" modified="2005-04-26" version="1">MPPNSKKKKKPAANPARGFATVSVPSKVKPTETSEPASTVDSKSVSESDRPTPSEPTHTAPSSDKTPSLQNYTPEELERHLEDAELQILVEKYAAKCKSDAVRQASKLETERRVLRQQAVSVNHVEWLPSDVVSSILALAEAEEQGLSPQPVRDKRVVTEDELCMKLWVLKDTLLRLGFPENRVEEALKHVLIYFAGNFTVTNRDVVCNLEEALEWLAMHCSLDELPSYTQTNGQRKDADKNVSWISDRETSGKSAPKFAAGSKMQKAKPVVRENITQPDPYDSDSSLDPDTLVPKYLDLQTRLYNLCPEIFDRPKKGKKGQPAGATDDPQALKLQRKISSIENDVLFDRKEAEYLWREKLDELRKEAAIFRRVDANAETEQVEKKESEPETPPALDDEADDILGGMFQDEEPTLELGVITEELNKASIATRDFGKWTGLSPRRVLEEACKARDSGCKVTYKDISTASHLNRMALEVRWSKPQEMPSPFSHEAVTQKSTSYATFVSMDKIATPTSQQAEAYASTFALFILFPQNSKEGKAYMRLPAAWRDLWEEFANAKKVQDDEADKQVVKSLRKLIQENHGTFEDDVVLSDNFRKRNGTPRNRSPVRAGAKEAPGINEQLSQIWMEKASTPAFQYMVQSRMQLPIWTFKNEILNTLNSHRALIICSETGSGKSTQIPSFILEHEMLSGRPCKIYVTEPRRISAISLARRVSEELGESKNDVGTSRSLIGFAVRLESKVSPATRLVFATTGVVVRMLERPDDFQDITHVVLDEVHERSIDSDFLLIVLRRLMQKRQDLKLILMSATVDANRFSTYLGGVPVLNIPGRTFPVETKFLEDAIELTQYRTTENESNVADDEYEDDAETSQGETTGVAATLENYSKQTRETIMNFDEYRLDYQLIKKLLMKLATAPEMEYYSKAILVFLPGMAEIRRLNDELLSEPTFQHGWIIHALHSSIASDEQEKAFVVPPDGMRKIVIATNIAETGITIPDITAVIDAGKEKTMRFDERRQLSRLVEAFISRANAKQRRGRAGRVQRGICFHMFTKHRHDNLLAEQQTPEMLRLSLQDLVLRVKICKLGEVEPTLLEALDPPSSKNIRRAIDALKEVKALTSTENLTPLGQQLAKLPLDVFLGKLIIHGAFFKCLDAAISIAAILSCKSPFVNTMGSNAQKEAVRLGFRRGDSDLLTVYNAYCAWKRTRSTPGANEYAFCRKNFLSPQTLLNIEDVKLQLMVSIADAGLVTLDTNQKASLNRARSTRQRHFFTTPPSHDTNNANDTLIQSVIAWSFYPKLLTREGKGWRNIANNQSVTLHPTSVNRVPSASSERSPGQSQYLSYYHIMQGRNRKYNAFETSAVEDWAVAVLCGEGDFKMYPGVLSIDTNRLRFSLRDWKSMLAMKVLATRIREILANVFRDPQQPLSYKQRQWMDIWQGIWQARM</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="102" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B1C0</accession>
    <accession>C8VFT5</accession>
    <name>Q5B1C0_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Plasma membrane sensor transducer (Eurofung)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ANIA_05660</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
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            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
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        <property type="protein sequence ID" value="CBF81457.1"/>
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    <dbReference type="KEGG" id="ani:ANIA_05660"/>
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    <dbReference type="eggNOG" id="KOG4157">
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        <property type="component" value="Chromosome V"/>
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        <property type="entry name" value="WSC_carb-bd"/>
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        <property type="entry name" value="LPXTG_anchor"/>
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    </dbReference>
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        <property type="entry name" value="MID2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
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        <property type="entry name" value="WSC"/>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
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    <feature type="chain" id="PRO_5010215911" evidence="7">
        <location>
            <begin position="25"/>
            <end position="280"/>
        </location>
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            <begin position="187"/>
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        </location>
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    <feature type="domain" description="WSC" evidence="8">
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            <begin position="26"/>
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="126"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="254"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="126"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBF81457.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B2I6</accession>
    <accession>C8VFC5</accession>
    <name>Q5B2I6_EMENI</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">ANIA_05244</name>
    </gene>
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        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF81161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_657756.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B2I6"/>
    <dbReference type="GeneID" id="2871538"/>
    <dbReference type="KEGG" id="ani:ANIA_05244"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN5244"/>
    <dbReference type="eggNOG" id="ENOG502SKGQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027514_1_0_1"/>
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        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027796">
        <property type="entry name" value="OTT_1508_deam-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42037">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42037:SF1">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14441">
        <property type="entry name" value="OTT_1508_deam"/>
        <property type="match status" value="1"/>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF81161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="456" mass="52426" checksum="ACA005FDE6706457" modified="2005-04-26" version="1">MKQGNSLTLVPKQIGPPRFDPYGRLLARFYESLFFWKYLGRTQGEHTPEPPVLDIHQECRRRFLKNLSYICDFRKGVQACTAIAVEDRVDCYRFWVASNMNVNKAVAFIREILAMLHDRHLDASNNESMIEASLIQRCVEFAAKRIDSEGRFLRIMANRCILMLEDEESEAGMTFFLSNLLERALSCSRNITLCRFLYDQRHSAAMKELSARAISDKGRPGRAEEDSCFSSARHHIGRLIHHIRAPIELAQDSRHLMYLTDAYTVCPVSPCSAVSCPVSDMHTNLQGILNRMFTADDEDRVAVGDGLVYINKTRPIFDTFLAEYNGRDRQVHAEIQVLEHFYQQRLSFLDGDRYIACSKPACLCCQLYFKHHPARMVVPASHQNVYTSWSPPLLPRFAKGDKDTQLQKQVLSYMAQDMREQIIQQVLQRSRSMIRHPDSRTSLTDLPAEAAFGFLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B2N5</accession>
    <accession>C8VF69</accession>
    <name>Q5B2N5_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Endosomal cargo receptor (Erv14), putative (AFU_orthologue AFUA_6G07290)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ANIA_05195</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cornichon family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF81057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_662799.1">
        <property type="nucleotide sequence ID" value="XM_657707.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B2N5"/>
    <dbReference type="SMR" id="Q5B2N5"/>
    <dbReference type="FunCoup" id="Q5B2N5">
        <property type="interactions" value="830"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5B2N5"/>
    <dbReference type="GeneID" id="2871485"/>
    <dbReference type="KEGG" id="ani:ANIA_05195"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN5195"/>
    <dbReference type="eggNOG" id="KOG2729">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112942_0_0_1"/>
    <dbReference type="InParanoid" id="Q5B2N5"/>
    <dbReference type="OMA" id="HKKECFI"/>
    <dbReference type="OrthoDB" id="434393at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003377">
        <property type="entry name" value="Cornichon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033466">
        <property type="entry name" value="Cornichon_conserved"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12290">
        <property type="entry name" value="CORNICHON-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03311">
        <property type="entry name" value="Cornichon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01398">
        <property type="entry name" value="Cornichon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01340">
        <property type="entry name" value="CORNICHON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBF81057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="138" mass="16118" checksum="764B9C13157B94EF" modified="2005-04-26" version="1">MSGEAWLYLLAVLINAVNLFLQVFFTIMYSDLECDYINPIDLCNRLNAYIIPEAGVHAFLTFLFVINGYWLAIALNLPLLAFNAKKIYDNQHLLDATEIFRKLNVHKKESFIKLGFHLLMFFFYLYSMIVALIRDESH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B3W4</accession>
    <accession>C8VAQ5</accession>
    <name>Q5B3W4_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Vacuolar ATPase assembly protein VMA22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_04766</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF76830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_662370.1">
        <property type="nucleotide sequence ID" value="XM_657278.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B3W4"/>
    <dbReference type="STRING" id="227321.Q5B3W4"/>
    <dbReference type="GeneID" id="2872565"/>
    <dbReference type="KEGG" id="ani:ANIA_04766"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN4766"/>
    <dbReference type="eggNOG" id="ENOG502S6WS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057721_0_0_1"/>
    <dbReference type="InParanoid" id="Q5B3W4"/>
    <dbReference type="OMA" id="GQDCYDE"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990871">
        <property type="term" value="C:Vma12-Vma22 assembly complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070072">
        <property type="term" value="P:vacuolar proton-transporting V-type ATPase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040357">
        <property type="entry name" value="Vma22/CCDC115"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31996">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31996:SF2">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21730">
        <property type="entry name" value="Vma22_CCDC115"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="145"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="184"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="201"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00093634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF76830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="316" mass="34535" checksum="788A54F0F62553F6" modified="2005-04-26" version="1">MTEISSDCPAALHISAFVLQLTTSPSTSLPEELLTIDACIACVHILRPMKQLPTPPASRQSSEVPDTDLKQLHIDDPTPDLLESLDALLEKYLHLLDKHQRLQHVLASKLSSGFLSLAHANYTCPPGRRYGADYYDERMKASRRVILRPPSSADREDSTAELESPPPNGASSKGIFSIEFTPSNDEEEQPDTDEPSGTGEKAPEKALEQEPLKKAGDNNAADTTASPQDSSEASETKTEADADADADARSGLVRRRPRTLDPIKWFGILVPPSLRSAQKSFTEAVEGSLPELAGIVVEMQAAEKEITELRRRMGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="130" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B424</accession>
    <accession>C8VAX0</accession>
    <name>Q5B424_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Myosin II homolog (Eurofung)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">ANIA_04706</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Binds to cdc4 and rlc1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF76957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_662310.1">
        <property type="nucleotide sequence ID" value="XM_657218.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q5B424">
        <property type="interactions" value="342"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5B424"/>
    <dbReference type="GeneID" id="2872506"/>
    <dbReference type="KEGG" id="ani:ANIA_04706"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN4706"/>
    <dbReference type="eggNOG" id="KOG0161">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000192_5_3_1"/>
    <dbReference type="InParanoid" id="Q5B424"/>
    <dbReference type="OMA" id="DVRFLHK"/>
    <dbReference type="OrthoDB" id="6108017at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032168">
        <property type="term" value="C:hyphal septin ring"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110085">
        <property type="term" value="C:mitotic actomyosin contractile ring"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120104">
        <property type="term" value="C:mitotic actomyosin contractile ring, proximal layer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032982">
        <property type="term" value="C:myosin filament"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043936">
        <property type="term" value="P:asexual sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903475">
        <property type="term" value="P:mitotic actomyosin contractile ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902404">
        <property type="term" value="P:mitotic actomyosin contractile ring contraction"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd01377">
        <property type="entry name" value="MYSc_class_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.820:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.530:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.720:FF:000001">
        <property type="entry name" value="Myosin heavy chain, muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.270.10:FF:000007">
        <property type="entry name" value="Myosin II homolog (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000101">
        <property type="entry name" value="Slow myosin heavy chain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.360">
        <property type="entry name" value="Myosin S1 fragment, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.270.10">
        <property type="entry name" value="Myosin, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055914">
        <property type="entry name" value="DUF7491"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008989">
        <property type="entry name" value="Myosin_S1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004009">
        <property type="entry name" value="SH3_Myosin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF857">
        <property type="entry name" value="MYOSIN-11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24319">
        <property type="entry name" value="DUF7491"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02736">
        <property type="entry name" value="Myosin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90257">
        <property type="entry name" value="Myosin rod fragments"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51844">
        <property type="entry name" value="SH3_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 9" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5 9" id="KW-0518">Myosin</keyword>
    <keyword evidence="2 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myosin N-terminal SH3-like" evidence="13">
        <location>
            <begin position="115"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="Myosin motor" evidence="12">
        <location>
            <begin position="169"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="9">
        <location>
            <begin position="741"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1687"/>
            <end position="1714"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="2263"/>
            <end position="2283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="2378"/>
            <end position="2404"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="933"/>
            <end position="1576"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="1605"/>
            <end position="1646"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="1722"/>
            <end position="1790"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="1834"/>
            <end position="1875"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="1939"/>
            <end position="2069"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="71"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1692"/>
            <end position="1707"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="262"/>
            <end position="269"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00064372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CBF76957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="2404" mass="276843" checksum="F60CE5629EF3AA04" modified="2005-04-26" version="1">MLPSQINGSPKRANPFSRASPSPSPTPSPQTKARPKSAVLASAGKFEEPKSHIRNSSSISHTSLAPFGRNANRQRSNSLRNDVTSGTFAPEFIKSEDLRHGADQIRGQEGDNDFSGNKYVWLRDPEKAFVKGLVLEEQDGARLLVQTDDGQQREVDVDQVDRVNPAKFDKADDMAELTHLNEASVVHNLHTRYLADLIYTYSGLFLVTVNPYCPLPIYSNEYINMYKGQSREETRPHIFAMADEAFRNLVEEGENQSILVTGESGAGKTENTKKVIQYLAAVATSDNMYSRSGSKQMNTLSQQILRANPILEAFGNSQTVRNNNSSRFGKFIRIEFSRSGQISGASIDWYLLEKSRVVKPNLQERNYHIFYQLLRGAEPKLKQKLLLSNLQIEDFAYTREGNDTIAGVSDEKEWDSLLEAFHIMNFSEEDQMCILRTVAAVLHLGNITIVKESLRADQAALSRDALDSVHKACQLLGIETEPFVKGLLHPKVKAGREWVEKVQTPEQVRLALDALAKGIYERGFGDLVNRINSRLERNTVTGEDSYFIGVLDIAGFEIFQNNSFEQLCINYTNEKLQQFFNHHMFVLEQEEYAREQIEWQFIDFGKDLQPTIDLIEVTNPIGIFSCLDEDCVMPKATDKSFTEKLHSLWDTKSTKYRASRLRQGFILTHYAAEVEYSTDGWLEKNKDPLNDNITRLLASSQDNHIAALFSDCGNADEVDHPRSRVKKGLFRTVAQRHKEQLSSLMNQLHSTHPHFVRCIIPNHKKRPKMLNAPLVLDQLRCNGVLEGIRIARTGFPNRLSFNEFRQRYEVLCRDMPKSYMDGQSAARIMLQKLALDKAWFRVGRTKVFFRAGVLAELEEKRDELIRTIMTRFQSVARGFVQRRISNKRLYRAEATHIIQHNFRAYLEMKANPWWRLFSRMKPLLGETRTAQEVKRRDEKIKQLETKMKQDQSERQKVEEERRRAEIEIQRIQQTLESERALALDKEEIFKRLQDREVELSEKLAGAIADQENLEDQLDELILAKKKTDEELDLRKTQLEQAGEIIQRLEAERKEMQQKLEDLEQKLLEAQSSASETENHMRELGQEVKMLQSHLSLKERKLQDLEAKLLKTDQDLDVKLAKTSKELDRSKKEVKDLLDENRTIRQQISDLSKTSTSYEEMLRRKESELTVLRNDAKKHAEEKKQLDVEKSNLSTRHDNMQNKLRELQAQVDAMVSEKIQLEREAADVQKLLQAKISEDAEAGESRKLLEQQIQDLKNQLFQAQADLSRERQSRDDVQMLAEHKLAELKDKFESLNEAKITIEKEMYIQQDSLRRATEARVAAEQSRKELQQELIKLRDRFTAAEDARLRAEAEMEQALVKQTTQRLESIRKELDNTQHRLEEVEAERSRLAAREQQLMNAIAESESFRIRHDQHKERLERELVTLKGRLTASENDNRALLTKIQQKNLDIARSNSKASESQRLRVATLQKEKAKLEEENKALSRQLGDQQLSITSLEKQKEKLALSVEDLNHEVNREHKASRNAERAASTASIQLAEANRNLETERQLRTQAQANTRKLQSALDSSNKEIDDLHRQLMLFHKIVEPEADPSADSWDKIQPDLSRKVDLAQLVETLQSQLQVSEEKYNRAEAQLAEMRRRHGEEMKELDARYSSSKRALLEEIDQNEVAHNRTPNHLRKNSETAIAKKFGAPTTPNRRLNINDNSNDSARSDRTVDTVGYQKRMDLAAEIEELQNKLQMSEMQNKHLQDQLARSVPPKDIWQDDSPSIRRMQLLERENGRLHEQLDDSSKKVSALERSIHSGELSLRDVQAKSHEELYDLINSQEQSRRSLLRVHNETVAEITDAKAQFEKLKRAKAALEVELRDACSEAQELQAAREQDALSRNQLLQEFSDLQIRLDAETSKSADLAASLSLYKSRADEYFSKLEQAEITLLKASRAEQFAKAQAKETEDNCAQIMAERKEMEAIIDDLQRQTQSLEARMEDQAAELQGALQAKQRLQNELEDYRNQRAIDIEDKETSMEQTRQKYQREITTLNNELEMEREKVLNGRTEASRLREELEDLRSKWDNEVLNSSTWAKEKSRMEVMLQDVTTSRDEAVNAHNDAQARVVSLLSQVRSLRTSIDDVTAERDMLHKEKKMLEARLTEAGERLEDLAKGESPSMRNAASMDRELLELKAKLAQQEDLSLAAVGKMRRAEALATEMQKEVTAEREATAQLFKDKAALEKQLKEAQLRCVDLETKSYSSGSQDIRFLHKRIKELETHLEEQEAKNNSEQRSLRNVDRTVKDLQSQIERREKMNAQLEEEVNRGREKVERLLKNIDELQQSESDSQLQARRAERELREEREKSLRLERELNGWKALRVERGGSAIARSHVAFSDAGSRKGSGAYTTGDLHRMPSNTKGFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B4M2</accession>
    <accession>C8V8C5</accession>
    <name>Q5B4M2_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Bax Inhibitor family protein (AFU_orthologue AFUA_2G03220)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ANIA_04508</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the BI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF77367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_662112.1">
        <property type="nucleotide sequence ID" value="XM_657020.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B4M2"/>
    <dbReference type="STRING" id="227321.Q5B4M2"/>
    <dbReference type="GeneID" id="2872304"/>
    <dbReference type="KEGG" id="ani:ANIA_04508"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN4508"/>
    <dbReference type="eggNOG" id="KOG1630">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046868_1_0_1"/>
    <dbReference type="InParanoid" id="Q5B4M2"/>
    <dbReference type="OMA" id="TLMWSER"/>
    <dbReference type="OrthoDB" id="1277691at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099093">
        <property type="term" value="P:calcium export from the mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007007">
        <property type="term" value="P:inner mitochondrial membrane organization"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006214">
        <property type="entry name" value="Bax_inhibitor_1-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291">
        <property type="entry name" value="BAX INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291:SF112">
        <property type="entry name" value="GROWTH HORMONE-INDUCIBLE TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01027">
        <property type="entry name" value="Bax1-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="180"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="231"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="269"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBF77367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="335" mass="36914" checksum="737FBF482D27A158" modified="2005-04-26" version="1">MAFFLRRPFAVPTALRQVPKSANTARFIHNSPFKPAQPKPSFASSSIFAKSRQTFQNAFRRPYMQQTANASQGDLTQKLIYGAAIVGGTIMATNFIFNRETREDGGMPPFERAYLNETFMHTGLGVGIIGIAARALHTSGWTYRLMATNPWLVAGVGLVASMGTMFGTYYTSPNNYIQKYALWAGFNVTQAALLAPLMFMHPAILARAGLYTVGMMGSIAFVGATAKQEKYLYLGAPLLAGVTIVALSGFAPLVLPATATRALMWSENIWLYGGLAVFGGFTLYDVQKVLHHARMSERGLLQKDVVNESISLELDFINIFIRMVQILAMRNNNRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="126" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B572</accession>
    <accession>C8V986</accession>
    <name>Q5B572_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein uL3m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ANIA_04308</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the universal ribosomal protein uL3 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF77796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_661912.1">
        <property type="nucleotide sequence ID" value="XM_656820.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B572"/>
    <dbReference type="FunCoup" id="Q5B572">
        <property type="interactions" value="821"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5B572"/>
    <dbReference type="GeneID" id="2872107"/>
    <dbReference type="KEGG" id="ani:ANIA_04308"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN4308"/>
    <dbReference type="eggNOG" id="KOG3141">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044142_0_1_1"/>
    <dbReference type="InParanoid" id="Q5B572"/>
    <dbReference type="OMA" id="GKNIPCT"/>
    <dbReference type="OrthoDB" id="274683at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0000318"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000004">
        <property type="entry name" value="50S ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.810:FF:000001">
        <property type="entry name" value="50S ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.810">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01325_B">
        <property type="entry name" value="Ribosomal_uL3_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000597">
        <property type="entry name" value="Ribosomal_uL3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019927">
        <property type="entry name" value="Ribosomal_uL3_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019926">
        <property type="entry name" value="Ribosomal_uL3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03625">
        <property type="entry name" value="L3_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11229">
        <property type="entry name" value="50S RIBOSOMAL PROTEIN L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11229:SF8">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL3M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00297">
        <property type="entry name" value="Ribosomal_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00474">
        <property type="entry name" value="RIBOSOMAL_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 8 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBF77796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="296" mass="31949" checksum="76E4462583CCB9E9" modified="2005-04-26" version="1">MPPRLSRRLVQLPFSNGAVIPQSHAQSAVFVRAFGIRSLNPPKHSKFNDSPELLKSSPAAALERKANTLPPRTGAIAIKKGMTAIFDPETGKRISCTVLQLDRVQVIAHKTVDVHGYYAVQMGAGWKHPNNVTKSLLGHFSEQGVSPKRHVYEFRVKDEDGLLPVGQLVNADWFHEGQYVDARSNTKGKGFAGVMKRHGFGGQDRSHGVSLTHRSLGSAGPSQGGGSRVYPGKKMAGNMGNEQNTVQNLKVLKVDAENGLVLVNGSVSGPKGCVVRIQDAIKKPWPVNPESAQSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="111" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B5F1</accession>
    <accession>C8V4A1</accession>
    <name>Q5B5F1_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">PHD finger domain protein, putative (AFU_orthologue AFUA_1G06260)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ANIA_04229</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF74437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_661833.1">
        <property type="nucleotide sequence ID" value="XM_656741.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B5F1"/>
    <dbReference type="STRING" id="227321.Q5B5F1"/>
    <dbReference type="GeneID" id="2873651"/>
    <dbReference type="KEGG" id="ani:ANIA_04229"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN4229"/>
    <dbReference type="eggNOG" id="KOG4323">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025799_0_0_1"/>
    <dbReference type="InParanoid" id="Q5B5F1"/>
    <dbReference type="OMA" id="FCHDPPI"/>
    <dbReference type="OrthoDB" id="5863171at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045814">
        <property type="term" value="P:negative regulation of gene expression, epigenetic"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd15502">
        <property type="entry name" value="PHD_Phf1p_Phf2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12628:SF10">
        <property type="entry name" value="HOMEOBOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12628">
        <property type="entry name" value="POLYCOMB-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="8">
        <location>
            <begin position="428"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="26"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="99"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="186"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="227"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="283"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="322"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="604"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="37"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="101"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="195"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="369"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="404"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBF74437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="681" mass="73054" checksum="EA4BBD2EE9AAC9E4" modified="2005-04-26" version="1">MGVHIPKLSAATTELLARIAGNIKGTQQKGLRRDDPTTVTLSPSPLSSNSDIQNTASRRAGKMKVSSTIIELPTFPFVYPTRVETPVVPPRPACMPLPASNDINGTTSKSDSLVNIAPKPTEPRTTSTSATAVPRVPVQTQLPLDQPPASNDVCEISARPHNLANIAPKPAAPHTSSIPALVVPHEQVHTRPPSEHQSPSSSRINGTLANQGSVNIAPKPAVLYPRLTTLPGGLSGQTQLSSDPPPSESIRGPLTEPKDLVNAAPEPLVTNLAPISIAVSGATAGVQRPPEHQLSPPPPIARAPTILKVPNLFLLKSSTAVPVKTTSTVRQRRDSSNRKSGPKKRKRGNDSDSEDIIRAVDSSSDESDVTPTATQTTSGRQVKRPSLYVPPPLIPSLPREGSSLAGTSDRPQTSRSRKPVPRKLKSTNIRCCVCDRSHSPTSNTIVFCDRCNRAWHQHCHDPPIQSEVVAIREKEWLCRECKPANITILHPTVVRSNPSLISKPPAHPPLTIPKTEVGGERFSTDCRRRFLSTLSHAALVELLLTISNNHPTVPMFPENMESLPSSNFAASQAIVTGAAATSTSLPTNENNVASVVLADNIDEQTPEFASGRTSGRNYRESSDEESEYEFQDHRVYPRAGNGLRLSTNEQDLDILQEDPTCSTFSYALHAPASGAVGHVSA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-09-11" modified="2026-01-28" version="107" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B5I6</accession>
    <accession>C8V4L3</accession>
    <name>MED10_EMENI</name>
    <protein>
        <recommendedName>
            <fullName>Mediator of RNA polymerase II transcription subunit 10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Mediator complex subunit 10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">nut2</name>
        <name type="synonym">med10</name>
        <name type="ORF">AN4194</name>
    </gene>
    <organism>
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Mediator complex subunit 10 family.</text>
    </comment>
    <comment type="sequence caution" evidence="3">
        <conflict type="erroneous gene model prediction">
            <sequence resource="EMBL-CDS" id="CBF74511" version="1"/>
        </conflict>
    </comment>
    <comment type="sequence caution" evidence="3">
        <conflict type="erroneous gene model prediction">
            <sequence resource="EMBL-CDS" id="EAA59293" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EMBL" id="AACD01000068">
        <property type="protein sequence ID" value="EAA59293.1"/>
        <property type="status" value="ALT_SEQ"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF74511.1"/>
        <property type="status" value="ALT_SEQ"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B5I6"/>
    <dbReference type="SMR" id="Q5B5I6"/>
    <dbReference type="FunCoup" id="Q5B5I6">
        <property type="interactions" value="546"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5B5I6"/>
    <dbReference type="eggNOG" id="KOG3046">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011638_0_0_1"/>
    <dbReference type="InParanoid" id="Q5B5I6"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019145">
        <property type="entry name" value="Mediator_Med10"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09748">
        <property type="entry name" value="Med10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0010">Activator</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_0000303171" description="Mediator of RNA polymerase II transcription subunit 10">
        <location>
            <begin position="1"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="54"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="62"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="165" mass="18452" checksum="D34A99427ADFFB52" modified="2007-09-11" version="2">MAPITLSTIDGKLKDIIQHLFEIQSAVHGYLGPETQQELVRKIKNLTTALQTLSLHTRDDPTASTTAPNQYQSTNPNDPALHSIALPPEIIDYVDAARNPDIYTREFVELVQRGNQDLKGKKEAFADFRDVLAREMRSAMPELRGEVDKVIQATGGKKQSERERG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="105" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B670</accession>
    <accession>C8V5Z0</accession>
    <name>Q5B670_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ANIA_03960</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF75006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_661564.1">
        <property type="nucleotide sequence ID" value="XM_656472.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B670"/>
    <dbReference type="STRING" id="227321.Q5B670"/>
    <dbReference type="GeneID" id="2873384"/>
    <dbReference type="KEGG" id="ani:ANIA_03960"/>
    <dbReference type="eggNOG" id="KOG1238">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002865_6_3_1"/>
    <dbReference type="InParanoid" id="Q5B670"/>
    <dbReference type="OMA" id="EHEIPLV"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF138">
        <property type="entry name" value="DEHYDROGENASE PKFF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010208615" description="Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="3">
        <location>
            <begin position="267"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBF75006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="463" mass="50325" checksum="92A8AAB24FD9EE49" modified="2005-04-26" version="1">MPSRLLRLTIAFALSLGSCSSLTSPVERGSNALFDYIVVGGGNAGLTLASRLSENSIVRVAVIEAGTFYERVTGNESIIPGNRGLYEGKAPSITNPLVEWGFMITPQAYLNESRIYMKLSGCTALNAMNYERPNAGSMDLWAAMVIDSSYAWDNSLHYFQKSIDFTPPDMSTRFANSTPSYDPTVLASGGPLSLTHPNYAQPFSSWLAEAMPEVDIGHIPGFRSGRLTMAERISFQEIAARGVIVSDMVSNRTFDLLARREVIISAGAFQSPQMLMVSGVGPAGLLAEHEIPLVADRPGVGQNMHDHVLFGVSYGVDVDTAYALGEPEAAAEAATLYHEDQAGPLSNRWRLCCLRKTPAGLSWWLVGRSRASDWPGIQGLFPAYAGNFYNPYVGGPREGNYVTLLAILMSPQSRGNAHSPRPVCWIPHSLIQPDSPIPSTWSSLLRRSSGCGVSSVRRYWKAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B6L1</accession>
    <accession>C8V6S2</accession>
    <name>Q5B6L1_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">High osmolarity glycerol pathway protein Nbp2, putative (AFU_orthologue AFUA_2G03680)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ANIA_03819</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF75316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_661423.1">
        <property type="nucleotide sequence ID" value="XM_656331.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B6L1"/>
    <dbReference type="STRING" id="227321.Q5B6L1"/>
    <dbReference type="GeneID" id="2873244"/>
    <dbReference type="KEGG" id="ani:ANIA_03819"/>
    <dbReference type="eggNOG" id="ENOG502RZ32">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024803_2_0_1"/>
    <dbReference type="InParanoid" id="Q5B6L1"/>
    <dbReference type="OMA" id="RGYYMGT"/>
    <dbReference type="OrthoDB" id="19092at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="289"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="100"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="356"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="48"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="120"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="362"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="373"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBF75316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="420" mass="45691" checksum="9E95FCCA2DB7FA3E" modified="2005-04-26" version="1">MTTATSPPPSQQAVSSPNLTVLPPLVTDTPVKMSSRQRSSSHGKDRLSTFSNLSVASQSRSRPGSHVFPIFHSSLPYALVRDFAYPTIHPFHYGPLPPSASGLSSPVSENRRLSDPPASWDSSRGQWSTQPWGTDTGHGHQQLPAMSFGDGPPYSEDEDLHSPVFSAPRHRRNKSTGSDLNGGGGKISGSNHYTRHMSIAGEYDRGRLVSMNADGSETYYVNDDDDADDGPGGDLVTYPPDESRFTYLGSYTDNHGYGRQEGFDSEEDYAGTHRYSREFQFSVGCPDEEMHGKAVALFDFTREHENELPLTEGQVIFVSYRHGQGWLVAEDPRTGESGLVPEEFVRLVRDIEGGLTSLNGEAEADDDDEYPSPDSTDSQQEITPTFQSAVNGDLGNPKSGNEKGENVAPSELGQLSGGKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B6X7</accession>
    <accession>C8V7K5</accession>
    <name>Q5B6X7_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CsbD-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_03703</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF75576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_661307.1">
        <property type="nucleotide sequence ID" value="XM_656215.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B6X7"/>
    <dbReference type="STRING" id="227321.Q5B6X7"/>
    <dbReference type="GeneID" id="2873119"/>
    <dbReference type="KEGG" id="ani:ANIA_03703"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN3703"/>
    <dbReference type="eggNOG" id="ENOG502STPC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_167691_0_0_1"/>
    <dbReference type="InParanoid" id="Q5B6X7"/>
    <dbReference type="OMA" id="DAGQWKK"/>
    <dbReference type="OrthoDB" id="2565331at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40636">
        <property type="entry name" value="CSBD-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40636:SF1">
        <property type="entry name" value="CSBD-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF75576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="94" mass="9111" checksum="0491537EA9A0BF11" modified="2005-04-26" version="1">MPNNNWSSNTSSNDSGVTGAAKFVTSTLGNTVGGVSKTLGGVTGAATRGLGDTVNSATGSSGRPVGDALGNVGTGLEDGLKKVGKGVEDAGQWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="104" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B7Y7</accession>
    <accession>C8VHU8</accession>
    <name>Q5B7Y7_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ANIA_03343</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF82905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_660947.1">
        <property type="nucleotide sequence ID" value="XM_655855.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B7Y7"/>
    <dbReference type="STRING" id="227321.Q5B7Y7"/>
    <dbReference type="GeneID" id="2874018"/>
    <dbReference type="KEGG" id="ani:ANIA_03343"/>
    <dbReference type="eggNOG" id="KOG1075">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000680_23_0_1"/>
    <dbReference type="InParanoid" id="Q5B7Y7"/>
    <dbReference type="OrthoDB" id="4501366at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="3">
        <location>
            <begin position="242"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="539"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBF82905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="960" mass="106551" checksum="6914A2A10EF3DA0B" modified="2005-04-26" version="1">MVADDQLVLLNDWKLAMTSLAKALDLTVSSLQGRPRDLARGLAARFVSLAKQDSPQQIPLMTAVAPPQPSRQMEQPNQPPTPEACEGPLKRQTSQPTTWASLTAPRAGQGNWQTIAPEHRTQAKQPAQRKLKQSNKTDHRIFLHLPASSSLRAIGPHGIWVTLAGKVPDGIAQVQVILTGYAITTTEQGKVFLLSEKALFSPPTRWTARPRTLTYVQRDLPAHSLPEPILPDITTIYTAGLTIINVYCPPNNLVAPAGAGSTPSILSTLLGYAPPENTILAGDFNTQHPFWQPDTESYAVIPGATGLLDWLDAHELELRLEPGTPTRGPNTLDLVFSNLPLRALVEDHLKTPSDHATIGIILEQEEPPPIYKLGSTNWEKARALASLPDPTLLIDLLAKQLLRKAIVRAKAEYWKQRIEQATAPIDAFKLAKWIQHPDQLAASPLNIQGAQVTTPQGKADAFLNYLLEKGALLPNQTEEGPPNKPLGSLHLPTKEHCWAALCAPPLSAPREDRLATTAWRELWPVLGDIITQLYYRYVKGVFDAVIHQRLLSHLHLQGWYKGLLQLLKDWLTGCSVSVHIKEGTATAPIKGRLPQGSPLSPILFLLYAARIVSTLEGSFCYADDMGILLTGNTLEESLQQLVEAYKQITALGTETGLPFSIEKTEIQYFSRKQQQHLPTVTLPGVLLDTKLTFKAHINLVFSRGKRLAQHLKRLSNTQRGCPVASMWAAVIHSPGYYSAAYKTTPTAALLREADLPDPEALLNSILWRAAKPLQVRWIPGHSGIAGNELADKLAKLGSSIYSPDIPPSPAYLRREAKQWLRTETYTAYANKAPETYKALNIRPHTKESRSREHKLPRWVLGRLVAACTGHGDFTAYHQHFDHTDYLESCTCGKAKTPVHFFFCPYTRKRWKDRWRCIKDGPSKTIDWLLSTAAGAEEFSRIMQESSFFKDICPNWARRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B824</accession>
    <accession>C8VHZ5</accession>
    <name>Q5B824_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_03306</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF82991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_660910.1">
        <property type="nucleotide sequence ID" value="XM_655818.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B824"/>
    <dbReference type="STRING" id="227321.Q5B824"/>
    <dbReference type="GeneID" id="2874483"/>
    <dbReference type="KEGG" id="ani:ANIA_03306"/>
    <dbReference type="eggNOG" id="KOG2806">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_458571_0_0_1"/>
    <dbReference type="InParanoid" id="Q5B824"/>
    <dbReference type="OMA" id="TWIKHER"/>
    <dbReference type="OrthoDB" id="73875at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055560">
        <property type="entry name" value="DUF7136"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029226">
        <property type="entry name" value="Ecp2-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23584">
        <property type="entry name" value="DUF7136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14856">
        <property type="entry name" value="Hce2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7136" evidence="2">
        <location>
            <begin position="101"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="Ecp2 effector protein-like" evidence="1">
        <location>
            <begin position="481"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF82991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="595" mass="65195" checksum="BA3E43803DAE2101" modified="2005-04-26" version="1">MNAFDILITIASQQQGNVTPSLSPRGQRLALAKVLAGCDFGAPVFGGFPPCFAFLTLVSTRVLPSATTICNSCYARRSYALPSSEPLARHLYVVETVTESVNVVELDFVFPRNETYAPTEDFPVVFAVKNTQHAELLSLRITYTIFKWDAKSISGSWPSTTIPEELLRLDWTNLSDPYLAYRYYNGTSPGHWWLTWHLSWQSCDVEALDDADSDGGLFTNTSRRRGCHNPILTFRTTEGSRPGRCNRSWETCCLTGQGWLVIAGWDNVTSIALTNFLDGSPESVESHTEIISDGKLTPGNATADSPDGDEEMYHWSRHSSPVASYTLVDAGHLCGEPKDISKSLDDDTQRATVVCVDGNQYYLAYPDGDARECPCDHLTDTGFCRKICRDNTFSPPTGLEYIASESNYYGITKDELVIGSVRTWIKHERENPAKPGDGDPAQAICVFPFAAPSEFFNLEKQQSNPNATPNYPCDIPAGNDDCGKSTFVDQTSDASPKIGDCCQTILNIQDDGSTDWTIQVVGKNQREIASHASCHFGVETTKVDGNVNSVVGGQEVIYIINDAIAQFGNKDGLVGAKGEMSCNGNVHDQAVLWGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="131" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B8V0</accession>
    <accession>C8VIU3</accession>
    <name>Q5B8V0_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">alcohol dehydrogenase (NADP(+))</fullName>
            <ecNumber evidence="9">1.1.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">ANIA_03030</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a primary alcohol + NADP(+) = an aldehyde + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15937"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15734"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:15938"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="10">
            <dbReference type="Rhea" id="RHEA:15939"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.2" evidence="9"/>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF83535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_660634.1">
        <property type="nucleotide sequence ID" value="XM_655542.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B8V0"/>
    <dbReference type="STRING" id="227321.Q5B8V0"/>
    <dbReference type="GeneID" id="2873746"/>
    <dbReference type="KEGG" id="ani:ANIA_03030"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN3030"/>
    <dbReference type="eggNOG" id="KOG0023">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_20_2_1"/>
    <dbReference type="InParanoid" id="Q5B8V0"/>
    <dbReference type="OMA" id="RNEWGIA"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008106">
        <property type="term" value="F:alcohol dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006066">
        <property type="term" value="P:alcohol metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd05283">
        <property type="entry name" value="CAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000158">
        <property type="entry name" value="Zinc-binding alcohol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047109">
        <property type="entry name" value="CAD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42683">
        <property type="entry name" value="ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="13">
        <location>
            <begin position="35"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="12">
        <location>
            <begin position="197"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CBF83535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="361" mass="39125" checksum="FBD81E866CF5F625" modified="2005-04-26" version="1">MAQQDYKFEGWMGLDKNAADGNMVWQEFEPKEWEETDVDIKITHCGICGSDLHTLRSGWRPALYPCCVGHEIVGTAVRVGSKAVGGIKLGDRVGVGAQSDACVGRFGDCPECAMGWENYCSHKFVSTYNSVHFNGGKSYGGYALYNRCPSHFVVKIPDAVPSAEAAPMLCGGVTLYSPLKHNNCGPGKRVGIIGVGGLGHFGVLFAKALGADKVVAISRKNGKSEDALKMGADQYIATDDEPDWATKYARSLDLIVCTVSSTKMPLAEYVGLLATNGSFVQVGLPEDGVLNAPVANLRRRLKMESSLVGSPNEIREMFALVAEKGIKPWIETVPMKDANKAIVDMHEGKARYRYVLVNEEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="121" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B8W6</accession>
    <accession>C8VIV9</accession>
    <name>Q5B8W6_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Translation repressor/antiviral protein Ski3, putative (AFU_orthologue AFUA_3G08810)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ANIA_03014</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF83564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_660618.1">
        <property type="nucleotide sequence ID" value="XM_655526.2"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q5B8W6">
        <property type="interactions" value="504"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5B8W6"/>
    <dbReference type="GeneID" id="2874052"/>
    <dbReference type="KEGG" id="ani:ANIA_03014"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN3014"/>
    <dbReference type="eggNOG" id="KOG1127">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001688_2_0_1"/>
    <dbReference type="InParanoid" id="Q5B8W6"/>
    <dbReference type="OMA" id="CQWELDP"/>
    <dbReference type="OrthoDB" id="421075at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055087">
        <property type="term" value="C:Ski complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039226">
        <property type="entry name" value="Ski3/TTC37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040962">
        <property type="entry name" value="TPR_22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15704">
        <property type="entry name" value="SUPERKILLER 3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15704:SF7">
        <property type="entry name" value="SUPERKILLER COMPLEX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18833">
        <property type="entry name" value="TPR_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="444"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="640"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="674"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="716"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="974"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="319"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1134"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="322"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBF83564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="1410" mass="158965" checksum="29FFBE6E67930F2C" modified="2005-04-26" version="1">MSSKSALKEVRAALDAKNFELAADKAKAIVKEQPQNYHANVFLGLAQDKLNHFLESERAYLAATRIKGDDKTAWQGLISLYERQGIQYLEQYREVVIKLGLVFAALDDKHRCQDVVDKYVAFTRKNGTRLQYKRALELHLPTSPLYDYLEGRLPHPAHTYQRLIEISESEEREFINREIGERRTRLGARIDQVTLEVKRDAYRRSELEELYRGIVNWSHDDQIRRTYEEKLLQRAYDVLTVLPANEKHAKREEVLQAARDMVIIKHPFELAWKIVLEWQDVENFSQWDRPFLEDFIEFFPGDDLTKVLKGFLASDLSPFPKEPAKRNEEAEKSENGNGEEVAAQDRLLMMVEGFEMSSASIVAHRIMAELYSSLEEYESVVDVCRKGLQNVDDLVRRTGISLQNTSDSLNIALANSLIYHQSPRNHPEAQRIFQDILQRHPTSTSCLLGIGLILKVDEDYPEAVNFLERALERDHSNLKVRGELSWCRALNGDLSSGLSGLQDVLEELQASEKENRVFKGEILYRIGYCQWEIDPSPAARKNRAGAYASFLASVQANISFAPAYTSLGLYYADYKKDKVRARRCFHKAFELSPSEIVAAERLARTFADQKEWDLVEAVSQRVVDSGKAKPAPGSKRKGYSWPYAALGTVQINKQQYPKSIVSFQAALRISPDDYHSWVGLGESYHNSGRYIAATKAFYHAQQLEPTLSNTEKGQIWFARYMLANVKRELGEYDDAIARYEEVLKIRPNELGVTIALLQTLTENSWKCLESGLFNDCAELARKAIIVAKSLATERADIFNLWKGVGDACAILSYVKSKAAKLPMKEVRGLLSTQLEASALCILTDVDDVGENHLTALDDGKDILTLANDCMYASILAYKRAIHVSLQDTHAQAVSWYNLGWAEYRASRCIKLVGEKKKQSRRLLKAAMRCFKRAIELEAGNSEFWNALGVVTTSMSPRVAQHAFVRSLHLNDRSAQVWTNLGTLYLIHNDIQLSNEAFTRAQSTDPDYSQAWVGQGFLALLFGEPREARGLFEHAFDISRSSSRLPKQQYTLTLFDHLVADASVSNEVSQLIQPLFTLYQLTSQDPSDLPFVHLFSLLAERIGEFSDAESNLRNLSLHVEAEYEVSESATSLSRYAQANADIARVLLARQEYEEAAEKAETALMLSSEEDSEKFEPEMYKNLRLSAHLTAGLAHYYMRAMDNAIDMFRDALQEADNSPDVVCLLAQVLWAKGGEEERTVARQQLFECVESYPDHVGAVTLLGAIALLDDDRDVIEAVESDLHNMITRDDIEIHQRARLIKLLTAISACVAGDSDVPSETRRIGEAAAAVMRAPYDPQGWLELSSAAQESHPAEMGVKTALQSVPPRSNLDANDLSKAYSQTGKASDALRAIMVAPWMQGGWQELSHIVSAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B946</accession>
    <accession>C8VJ47</accession>
    <name>Q5B946_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Copper transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ANIA_02934</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF83720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_660538.1">
        <property type="nucleotide sequence ID" value="XM_655446.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B946"/>
    <dbReference type="FunCoup" id="Q5B946">
        <property type="interactions" value="514"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5B946"/>
    <dbReference type="GeneID" id="2874424"/>
    <dbReference type="KEGG" id="ani:ANIA_02934"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN2934"/>
    <dbReference type="eggNOG" id="KOG3386">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079690_4_0_1"/>
    <dbReference type="InParanoid" id="Q5B946"/>
    <dbReference type="OMA" id="AKTVACH"/>
    <dbReference type="OrthoDB" id="161814at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005375">
        <property type="term" value="F:copper ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007274">
        <property type="entry name" value="Cop_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483:SF115">
        <property type="entry name" value="COPPER TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 31 COPPER TRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04145">
        <property type="entry name" value="Ctr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="4" id="KW-0187">Copper transport</keyword>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="169"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="113"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBF83720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="198" mass="21719" checksum="600ADCB0B53E4274" modified="2005-04-26" version="1">MDMYHMGMDMDHSHHEHGDMDMGGNQCSMNMLFTWSTKNLCIVFSTWRVTGPLSLLGSLVVIVLLAAGYEGIRQVTRKYEVAHARRLSAFSTAVVGSNEFADEDVTGSGPGHESQSQAYVPNASSPLLVGSDNRRAMERRGKITMAALYGVQVFYSFFIMLLFMTYNGFVMLAVAIGAFVGYLAFGENMSATKSVACH</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-07-11" modified="2026-01-28" version="113" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B995</accession>
    <accession>C8VJ98</accession>
    <name>NHP6_EMENI</name>
    <protein>
        <recommendedName>
            <fullName>Non-histone chromosomal protein 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">nhp6</name>
        <name type="ORF">AN2885</name>
    </gene>
    <organism>
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">DNA-binding protein that induces severe bending of DNA. Required for DNA-binding by the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. Also augments the fidelity of transcription by RNA polymerase III independently of any role in the FACT complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Weakly associates with the stable spt16-pob3 heterodimer to form the FACT complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the NHP6 family.</text>
    </comment>
    <dbReference type="EMBL" id="AACD01000051">
        <property type="protein sequence ID" value="EAA63456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF83812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_660489.1">
        <property type="nucleotide sequence ID" value="XM_655397.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B995"/>
    <dbReference type="SMR" id="Q5B995"/>
    <dbReference type="FunCoup" id="Q5B995">
        <property type="interactions" value="425"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5B995"/>
    <dbReference type="EnsemblFungi" id="CBF83812">
        <property type="protein sequence ID" value="CBF83812"/>
        <property type="gene ID" value="ANIA_02885"/>
    </dbReference>
    <dbReference type="GeneID" id="2874036"/>
    <dbReference type="KEGG" id="ani:ANIA_02885"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN2885"/>
    <dbReference type="eggNOG" id="KOG0381">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082854_10_1_1"/>
    <dbReference type="InParanoid" id="Q5B995"/>
    <dbReference type="OMA" id="MKNMGGK"/>
    <dbReference type="OrthoDB" id="1919336at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01390">
        <property type="entry name" value="HMG-box_NHP6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.10:FF:000016">
        <property type="entry name" value="FACT complex subunit SSRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050342">
        <property type="entry name" value="HMGB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN DSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112:SF22">
        <property type="entry name" value="MITOCHONDRIAL TRANSCRIPTION FACTOR A, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00886">
        <property type="entry name" value="HIGHMOBLTY12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0158">Chromosome</keyword>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_0000245218" description="Non-histone chromosomal protein 6">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="2">
        <location>
            <begin position="27"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="60"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="12"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="61"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="106" mass="12016" checksum="C29FE86EA44EAF84" modified="2005-04-26" version="1">MPKANPTRKTKATRETGGRKKKDPNAPKRGLSAYMFFANDNRDKVREENPGISFGQVGKMLGEKWKSLSDKERKPYEDKAAADKKRYEDEKAAYKAGEAEEDEESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B9A0</accession>
    <accession>C8VJA3</accession>
    <name>Q5B9A0_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">DUF221 domain protein, putative (AFU_orthologue AFUA_3G11660)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">ANIA_02880</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CSC1 (TC 1.A.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF83820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_660484.1">
        <property type="nucleotide sequence ID" value="XM_655392.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B9A0"/>
    <dbReference type="SMR" id="Q5B9A0"/>
    <dbReference type="GeneID" id="2873910"/>
    <dbReference type="KEGG" id="ani:ANIA_02880"/>
    <dbReference type="eggNOG" id="KOG1134">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009187_1_0_1"/>
    <dbReference type="InParanoid" id="Q5B9A0"/>
    <dbReference type="OMA" id="VVCAWAF"/>
    <dbReference type="OrthoDB" id="2150324at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005227">
        <property type="term" value="F:calcium-activated cation channel activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045122">
        <property type="entry name" value="Csc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003864">
        <property type="entry name" value="CSC1/OSCA1-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027815">
        <property type="entry name" value="CSC1/OSCA1-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032880">
        <property type="entry name" value="CSC1/OSCA1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018:SF149">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11660)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
        <property type="entry name" value="PROBABLE MEMBRANE PROTEIN DUF221-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14703">
        <property type="entry name" value="PHM7_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02714">
        <property type="entry name" value="RSN1_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13967">
        <property type="entry name" value="RSN1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="117"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="381"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="429"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="476"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="520"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="547"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="591"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="645"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="670"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like N-terminal transmembrane" evidence="11">
        <location>
            <begin position="31"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like cytosolic" evidence="12">
        <location>
            <begin position="203"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like 7TM region" evidence="10">
        <location>
            <begin position="381"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="271"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="820"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="299"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="273"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="286"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="822"/>
            <end position="832"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF14703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CBF83820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="1033" mass="116987" checksum="0CB4EDD2D97C266E" modified="2005-04-26" version="1">MDYRALWRRDGAEEFLKLIQDPFKSAFQTNAVWASLATSAVVAIVLALLFSLFRPRHTLVYAPKVKHADRKHAPPPVGKGLFAWIKPVIRTKEAELVDCVGLDATIFIRFTKMCRNIFIFLSIIGCGVMIPVNLTQSQNTDGATAFVVMTPLYVKVNAIWSQVVCAWAFNIIITFFLWRNYKAVLALRRRYFESSDYQRSLHARTLMITDIPPDLRTDEGFLRLTDELNPTAALPRSSVGRNVKGLPKLIKEHEELVRKLESVLAKYLKNPDRLPPSRPTMRPPRGHRDEDGSGKVDAIDYLTDRIQRLEEEIRHVRASIDKRNAMPYGFVSWDKIEHAHAVAYVARNKHPRGTTIRLATRPHDLIWENLSLSKSARKWKAFVMFLWVTALTVVWIAPNALIAVFLSNLSNLGSVWPAFQTELDRNRKVWAAVQGILSPAVTSLFYLLLPIIFRRLSARTGDATKTLREQHVLRHLYSFFVFNNLIVFSLFSAVWTFIAAVIDLKNKNEDPWQAVQDGQFYIKAFSAMCNVSPFWVTYLLQRNMGAAIDLVQFVHLIWVWFAKTFLAPTPRQTIEWTAPPAFDYASYYNYFLYYSTIAICFATLQPIVLPVTALYFGLDAMMKKYMLMYIFVTKNESGGQFWRVLFNRVVFAAILSNVIIGLVAKARGTWNMVYCVVPLPFLMLLFKWYCMRTFDDDCTYYNKANLSDTEALAASKSSKSAGDRLSSKFGHPALFKPLITPMVHAKAADALKQIYRGRLGGNEAEGDYSDIVMDPMMKSQPGKTMPDTSAPFEVVPEHHLDFAYYKDRADFQEEFGGGIYGRPEDLMTERSHTPRSALGDWSPTSSRAPSPAPSVPSLPMLQPEAYDPRLNQGMHPVFRPPPFRTGSGMSRGLYQHQNESETELLGQVQQPAGVSMQPWRPGGGYGPVDQDDHAFTSYEQYLVSIVPENYTLAVRQQPQAPGACLPITGLGRSLFPDNTRTTDSRSLGSPSATVARPELYDAVAISNSRCLYKPALCKLNQQPIRRCLVQHLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B9T4</accession>
    <accession>C8VKC2</accession>
    <name>Q5B9T4_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ANIA_02696</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF84193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_660300.1">
        <property type="nucleotide sequence ID" value="XM_655208.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B9T4"/>
    <dbReference type="GeneID" id="2874299"/>
    <dbReference type="KEGG" id="ani:ANIA_02696"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN2696"/>
    <dbReference type="eggNOG" id="KOG1231">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_750113_0_0_1"/>
    <dbReference type="InParanoid" id="Q5B9T4"/>
    <dbReference type="OrthoDB" id="2151789at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051264">
        <property type="entry name" value="FAD-oxidored/transferase_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43716">
        <property type="entry name" value="D-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43716:SF1">
        <property type="entry name" value="D-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010241349" description="FAD-binding PCMH-type domain-containing protein" evidence="3">
        <location>
            <begin position="23"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBF84193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="369" mass="40864" checksum="F61D1028A7A12580" modified="2005-04-26" version="1">MNSILPWSLVLLALGFAECVLSNPRQNASIAAIGTVNLQTGVDYQILFPNLADYTTQTIQMSGQALARHYPGSNNIDGGVLLALNSMKDYKVDNEAITLCHVATRPLLNPQGRRQQLRRSDKIPTTDILDAHISTTIQQFNETGIYDFVRASCNLVLADDDASTAAGVILTITYNVTTSRASAVILGVQEGIISPPPRFANFIAIPGTSKAHNVTTSKQWYRVRPSLHVRDLESSGGADRRHPGPVPNLRVNLSPASAASVAKTNQIGNTWGVFEEPLIWWQVTTGWDRAEDSLRVEAWVRHLVEHLHANNKRNNLAREFIYMGDAGEWQDPFVGFPAENVQRMRDIRQIYDPSGTFSRLNWGGFKLGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BAC8</accession>
    <accession>C8VPI1</accession>
    <name>Q5BAC8_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_02502</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF86984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_660106.1">
        <property type="nucleotide sequence ID" value="XM_655014.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BAC8"/>
    <dbReference type="GeneID" id="2874813"/>
    <dbReference type="KEGG" id="ani:ANIA_02502"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN2502"/>
    <dbReference type="HOGENOM" id="CLU_087020_0_0_1"/>
    <dbReference type="InParanoid" id="Q5BAC8"/>
    <dbReference type="OMA" id="CPRYYST"/>
    <dbReference type="OrthoDB" id="4227585at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF86984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="227" mass="24781" checksum="6C185CA61DB6C9FC" modified="2005-04-26" version="1">MLPSASSNSSQSSFDSPISQYPPQQHAWFPAPVPSMPRRRELPKFPRFYSTPLDQDHPDSTPLNIYGLEEREPSIAERPRRFLRFSRALDDIKEDFTSQPNPRNTAEAIRARRQSTFSSFFFDNNSNPTLSSVGPASASASVFHSSGASVASGAGSISPDSDSASSAGARPFPPPPPIPESSTQRPTLGRRLSRRLSRLSFSQRRASYRAGSASISQPNLIGSSNQL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2010-06-15" modified="2026-01-28" version="100" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BB53</accession>
    <accession>C8VML9</accession>
    <accession>Q1HFU7</accession>
    <name>BGLI_EMENI</name>
    <protein>
        <recommendedName>
            <fullName>Probable beta-glucosidase I</fullName>
            <ecNumber>3.2.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Beta-D-glucoside glucohydrolase I</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Cellobiase I</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Gentiobiase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">bglI</name>
        <name type="ORF">AN2227</name>
    </gene>
    <organism>
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="11417" last="11422">
            <title>Development and application of a suite of polysaccharide-degrading enzymes for analyzing plant cell walls.</title>
            <authorList>
                <person name="Bauer S."/>
                <person name="Vasu P."/>
                <person name="Persson S."/>
                <person name="Mort A.J."/>
                <person name="Somerville C.R."/>
            </authorList>
            <dbReference type="PubMed" id="16844780"/>
            <dbReference type="DOI" id="10.1073/pnas.0604632103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Beta-glucosidases are one of a number of cellulolytic enzymes, and catalyze the last step releasing glucose from the inhibitory cellobiose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text>Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <comment type="sequence caution" evidence="4">
        <conflict type="erroneous gene model prediction">
            <sequence resource="EMBL-CDS" id="CBF86422" version="1"/>
        </conflict>
    </comment>
    <comment type="sequence caution" evidence="4">
        <conflict type="erroneous gene model prediction">
            <sequence resource="EMBL-CDS" id="EAA63912" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EC" id="3.2.1.21"/>
    <dbReference type="EMBL" id="DQ490477">
        <property type="protein sequence ID" value="ABF50853.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AACD01000036">
        <property type="protein sequence ID" value="EAA63912.1"/>
        <property type="status" value="ALT_SEQ"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF86422.1"/>
        <property type="status" value="ALT_SEQ"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_659831.1">
        <property type="nucleotide sequence ID" value="XM_654739.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BB53"/>
    <dbReference type="SMR" id="Q5BB53"/>
    <dbReference type="STRING" id="227321.Q5BB53"/>
    <dbReference type="CAZy" id="GH3">
        <property type="family name" value="Glycoside Hydrolase Family 3"/>
    </dbReference>
    <dbReference type="GlyCosmos" id="Q5BB53">
        <property type="glycosylation" value="2 sites, No reported glycans"/>
    </dbReference>
    <dbReference type="KEGG" id="ani:ANIA_02227"/>
    <dbReference type="eggNOG" id="ENOG502QR4D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004542_4_0_1"/>
    <dbReference type="InParanoid" id="Q5BB53"/>
    <dbReference type="OrthoDB" id="47059at2759"/>
    <dbReference type="UniPathway" id="UPA00696"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.300:FF:000006">
        <property type="entry name" value="Beta-glucosidase H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000495">
        <property type="entry name" value="Periplasmic beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000119">
        <property type="entry name" value="Probable beta-glucosidase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019800">
        <property type="entry name" value="Glyco_hydro_3_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037524">
        <property type="entry name" value="PA14/GLEYA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011658">
        <property type="entry name" value="PA14_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF27">
        <property type="entry name" value="BETA-GLUCOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07691">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00758">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56988">
        <property type="entry name" value="Anthrax protective antigen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00775">
        <property type="entry name" value="GLYCOSYL_HYDROL_F3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51820">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword id="KW-0136">Cellulose degradation</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0326">Glycosidase</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0624">Polysaccharide degradation</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <feature type="chain" id="PRO_0000394890" description="Probable beta-glucosidase I">
        <location>
            <begin position="1"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="domain" description="PA14" evidence="3">
        <location>
            <begin position="396"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="225"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="197"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="839" mass="92621" checksum="8790901E0381A819" modified="2010-06-15" version="2">MPQLDVDKTIEELRLGEKIDLVSGIDFWHTASVPRLNIPSLRMSDGPNGVRGTRFFNGVPAACFPCATALGATWDTELLHKVGHLMGEEAIAKGAHVILGPTINTQRSPLGGRGFESFAEDGVLAGHLAGYCSKGIQEKGVAACLKHFVCNDQEHERLAVDSIVTDRATREIYLLPFQIAMRICKTATVMTAYNKINGTHVSENKKYITDILRKEWGWDGLVMSDWFGTYSCTSESIIAGLDIEMPGKTRWRGDALAHAVSSNKVHEFVLDERVRNVLNLVNYVEPLGIPENAEEKVLNRPEDQALLRRAAAESIVLLKNEDNILPFNKEKSIAVIGPNAKIAAYCGGGSASLDAYYTITPFEGVSAQSKGEVHFAQGSYSYKDLPLIGHLLKTDDGKTGFKFRVYDEPASSSNRELLHELHLVSSQGFLMDYRHPKIKSYLYYVDMEGYFTPEESGVYDFGVVVVGTGKLLVDDEVVVDNTKNQRLGSAFFGNGTVEEKGSKELMAGQKYKITFQFGTAPTSDIDTRGVVIFGPGGFRFGAARRQTQEELISKAVEVASKADQVVVFAGLTSEWETEGYDRPDMDLPPGSDELISKILEVKPNAAIVIQSGTPVTMPWAPKAKALLQAWFGGNECGNGIADVLYGNVNPSGKLPLTFPVRLQDNPSYLNFRSERGRVLYGEDIYVGYRYYEKAQLPPLFPFGHGLSYTTFTREKLELNTSPEKDKLQDGEPITARVTVTNTGKVAGAETVQLWVVPPPTEVNRPVRELKGFAKVHLEPGESKDVEIVVEKKLATSWWDEKREAWASEKGVYWVQVTGTGEGVLTAEFEVKKTRFWTGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BBG3</accession>
    <accession>C8VLZ8</accession>
    <name>Q5BBG3_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Lincomycin-condensing protein lmbA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ANIA_02117</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
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            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF86212.1"/>
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        <property type="nucleotide sequence ID" value="XM_654629.1"/>
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    <dbReference type="KEGG" id="ani:ANIA_02117"/>
    <dbReference type="eggNOG" id="ENOG502SR07">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086437_0_0_1"/>
    <dbReference type="InParanoid" id="Q5BBG3"/>
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    <dbReference type="OrthoDB" id="440424at2759"/>
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        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038213">
        <property type="entry name" value="IFI6/IFI27-like_sf"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF86212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="160" mass="16935" checksum="43E059DD6867AFBF" modified="2005-04-26" version="1">MCILQPFLDCIFGTRPPTTNTVNATSSRSLESIASDVVTKILTADSHDTLHKELNDQISTTSWTEALAKATLKGLENAIKTGAKMAKAAADAVAQAKEAAIGFATEHPVYATLIALGVLAVLTPWILEVLGFGELGPIEASFAARWQSLYRGSEKLACCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BBS6</accession>
    <accession>C8VLD2</accession>
    <name>Q5BBS6_EMENI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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    <gene>
        <name evidence="2" type="ORF">ANIA_02004</name>
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    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF85995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_659608.1">
        <property type="nucleotide sequence ID" value="XM_654516.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BBS6"/>
    <dbReference type="GeneID" id="2875199"/>
    <dbReference type="KEGG" id="ani:ANIA_02004"/>
    <dbReference type="eggNOG" id="ENOG502SY3Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101047_1_0_1"/>
    <dbReference type="InParanoid" id="Q5BBS6"/>
    <dbReference type="OMA" id="KEEFMHA"/>
    <dbReference type="OrthoDB" id="4502478at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="141"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF85995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="190" mass="21619" checksum="91621D6B9BEDBCC5" modified="2005-04-26" version="1">MPPVGPRASKEEFMAALGLNSHDPQHEQYYRAMRDETILIYNLLNTSPSNLLDTLTNTSDKPKPPYFWHHIKPERQQWAIREIARNATPRTKALFASGETSGEYGPNWVAGWLLYSVFRSRDVRNNRNRRRGEDNSGGQSGNQSQAGGQARASDTGQGQVKKEYYDPVRNGLPERNVKREWIDDASICVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="102" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BBU2</accession>
    <accession>C8VL64</accession>
    <name>Q5BBU2_EMENI</name>
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        <submittedName>
            <fullName evidence="5">Exocyst complex component Sec6, putative (Eurofung)</fullName>
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    </protein>
    <gene>
        <name evidence="5" type="ORF">ANIA_01988</name>
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    <organism evidence="5 6">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
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        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
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            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEC6 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF85958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="XP_659592.1">
        <property type="nucleotide sequence ID" value="XM_654500.1"/>
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    <dbReference type="AlphaFoldDB" id="Q5BBU2"/>
    <dbReference type="FunCoup" id="Q5BBU2">
        <property type="interactions" value="249"/>
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    <dbReference type="STRING" id="227321.Q5BBU2"/>
    <dbReference type="GeneID" id="2874877"/>
    <dbReference type="KEGG" id="ani:ANIA_01988"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN1988"/>
    <dbReference type="eggNOG" id="KOG2286">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011776_0_1_1"/>
    <dbReference type="InParanoid" id="Q5BBU2"/>
    <dbReference type="OMA" id="MNIGPKT"/>
    <dbReference type="OrthoDB" id="190098at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051601">
        <property type="term" value="P:exocyst localization"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.50:FF:000006">
        <property type="entry name" value="Exocyst complex component sec6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.70:FF:000005">
        <property type="entry name" value="Exocyst complex component Sec6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.70">
        <property type="entry name" value="Exocyst complex component Sec6, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010326">
        <property type="entry name" value="EXOC3/Sec6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042532">
        <property type="entry name" value="EXOC3/Sec6_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21292:SF1">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21292">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT SEC6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06046">
        <property type="entry name" value="Sec6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="119"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBF85958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="759" mass="88383" checksum="9721FEE4ECD64D67" modified="2005-04-26" version="1">MAQGGNADRAVAMPRLEDLLRHPEDLDKINGLKAEYTRKKAAVDAQLREGLRDQLASVQRSLSALTEGQRQVSKTRDELQGIDRLCAESQNSVDDFSRIDQLAKIQRNFEATLMMKKGLENFSSDLAEIEELLREDDEDLENQPNLLRTHMRISRLRDFRDEAMDQVRRAQDASNEATLEEYFQGLDAVIDWFDDHLGTLCMNLIPLVQSDNPSMVVRLAVVVANEEKNDETVKALQEAQKDHQDLAGRFKSMNVGPKTVRGYKEKFIQAIEFYAQNQFEDTKEKFLDDPEGLEKSFRWFFNDLFVVQQGMQSLMPKKWKIFKTYTDIYHRMMHDFLIEMVNDPALPADNLLAILHWREKYYKKMKKLGWQASDLELDILDNREPDLIRRWQNVIINAVEDWMDKITETDRKALTERIPDSLDTTADGYFRTQTLPDMWRMLHEQVTVSSSSSRPDLLEGIMDAMFRVLKARQNAWQTLLEEECAKYKAPGGEQLDGLQLLQDWLIAVANDQIACIDDNDETGQYGHLTRFRRDIEQYVDPKYMASRAIPEIDALRDGYVDLSTYCISQFVNVIFAVDLQGTIRDFFTQRWYGDFAVKRITSTFDDYMADYSPVLHPSLTDILVEELSDELLVRYLSSVRNKGVKFRRQTDPYTDKFKDDVLTVFAFFQKYPDSFAGTIKQKWRLVDWLVRLLEAEKGPAVVNVYEDFKNEYWDLQLSWVETVLRARDDFERSMITAVKTKAAELSVERGMETLMSRVR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2010-06-15" modified="2026-01-28" version="111" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BCI8</accession>
    <accession>C8VP45</accession>
    <name>MANBA_EMENI</name>
    <protein>
        <recommendedName>
            <fullName>Beta-mannosidase A</fullName>
            <ecNumber>3.2.1.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Mannanase A</fullName>
            <shortName>Mannase A</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">mndA</name>
        <name type="ORF">AN1742</name>
    </gene>
    <organism>
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Exoglycosidase that cleaves the single beta-linked mannose residue from the non-reducing end of beta-mannosidic oligosaccharides of various complexity and length. Involved in the degradation of polymeric mannan and galactomannan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>Hydrolysis of terminal, non-reducing beta-D-mannose residues in beta-D-mannosides.</text>
            <dbReference type="EC" id="3.2.1.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text>Glycan metabolism; N-glycan degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 2 family. Beta-mannosidase A subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.25"/>
    <dbReference type="EMBL" id="AACD01000027">
        <property type="protein sequence ID" value="EAA64028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF85479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_659346.1">
        <property type="nucleotide sequence ID" value="XM_654254.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BCI8"/>
    <dbReference type="SMR" id="Q5BCI8"/>
    <dbReference type="STRING" id="227321.Q5BCI8"/>
    <dbReference type="CAZy" id="GH2">
        <property type="family name" value="Glycoside Hydrolase Family 2"/>
    </dbReference>
    <dbReference type="GlyCosmos" id="Q5BCI8">
        <property type="glycosylation" value="14 sites, No reported glycans"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CBF85479">
        <property type="protein sequence ID" value="CBF85479"/>
        <property type="gene ID" value="ANIA_01742"/>
    </dbReference>
    <dbReference type="KEGG" id="ani:ANIA_01742"/>
    <dbReference type="eggNOG" id="KOG2230">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005015_3_0_1"/>
    <dbReference type="InParanoid" id="Q5BCI8"/>
    <dbReference type="OMA" id="PWKPAYI"/>
    <dbReference type="OrthoDB" id="2866996at2759"/>
    <dbReference type="UniPathway" id="UPA00280"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004567">
        <property type="term" value="F:beta-mannosidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006516">
        <property type="term" value="P:glycoprotein catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000200">
        <property type="entry name" value="Beta-mannosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001511">
        <property type="entry name" value="Beta-mannosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:002310">
        <property type="entry name" value="Beta-mannosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000084">
        <property type="entry name" value="Beta-mannosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054593">
        <property type="entry name" value="Beta-mannosidase-like_N2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050887">
        <property type="entry name" value="Beta-mannosidase_GH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041625">
        <property type="entry name" value="Beta-mannosidase_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Ig-like_GH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041447">
        <property type="entry name" value="Mannosidase_ig"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43730">
        <property type="entry name" value="BETA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43730:SF5">
        <property type="entry name" value="BETA-MANNOSIDASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22666">
        <property type="entry name" value="Glyco_hydro_2_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17753">
        <property type="entry name" value="Ig_mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17786">
        <property type="entry name" value="Mannosidase_ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="beta-Galactosidase/glucuronidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0326">Glycosidase</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0624">Polysaccharide degradation</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000394649" description="Beta-mannosidase A">
        <location>
            <begin position="22"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="476"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="15"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="39"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="245"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="314"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="321"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="344"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="534"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="605"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="626"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="653"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="733"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="761"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="785"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="940" mass="105765" checksum="45E1CBB33D2AFAF0" modified="2005-04-26" version="1" precursor="true">MHFHGIATQAVLASNITTGSGRHVSLSDVKWTLSSSALNSTVPASLPSQAHLDLLNAGVIDDPYYGLNEIDLQWIAQANWTYTSDPIPDLLEEYESTWLVFEGLDTFATVTFCGHNIASTNNQFRQYAFDVSSALKECTGGPVVRIDFASAPNTVDAIAADPKTPVWPVQLTAQLPNRWLMRKQQSDFGWDWGPAFAPCGPWKPAYVVQLEKTAPIHVLNTDLDIYRQGNINHLPPDQKQPWVVNASIDFIGRLPAEPRLLIEIKELETGDVLASQISDSVTLIGTSITGVTTLKDASPKLWWPSSLGAQNLYNVTITVFNKTEEVARITKRTGFRTIFLNQRNITATQLSQGIAPGANWHFEVNGKEFYAKGSNFIPPDTFWPRVTKQKMTRLLDAVVAGNQNMLRIWSSGAYLPDFIYDLADERGILLWSEFQFSDSMYPVDEDFLDNVAQEVVYNVRRVNHHPSLALWAGGNEIESLMLPLTREADPDNYPKYLAEYEKLYISLILPLVYENTRSISYSPSSTTEGYLSVNLSAPVPMTERYENDEPGAYYGDTDYYNYDTTVSFDYSIYPVGRFANEFGFHSMPSLQTWQQVADPEDLYFNSTTVVIHNRHYTSEGYGRIENSSRGMAEMTLGVERYYPIPDNPDSVANFSAWCLATQLFQADFYKSQIQFYRRGSGMPERQLGSLYWQLEDIWQGPTWAGIEYDGRWKVLHYVARDVYQPIIVSPFWNYTTGDLEIYVTADLWESAAGTVNLKWLNLSGEQIIDNAGTPTEIPFTVGAINTTKVYSTNIHDLNLPDTRASILTLSLSSQANLPNAAVKTSLTHENHFTPSFPKDLELVNPGLELSYDAHSGIFTVEAKSGVSLYTWLDYPAGLVGYFTENAFLLVPGQKKKVQFVVQDGPKDQDWEWQSEVTVRSLWDQKSSTFLYALRVATGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BCL6</accession>
    <accession>C8VNW4</accession>
    <name>Q5BCL6_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_01714</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF85420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_659318.1">
        <property type="nucleotide sequence ID" value="XM_654226.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BCL6"/>
    <dbReference type="GeneID" id="2875406"/>
    <dbReference type="KEGG" id="ani:ANIA_01714"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN1714"/>
    <dbReference type="HOGENOM" id="CLU_1019335_0_0_1"/>
    <dbReference type="InParanoid" id="Q5BCL6"/>
    <dbReference type="OMA" id="DGSWNQY"/>
    <dbReference type="OrthoDB" id="4148828at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF85420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="253" mass="28676" checksum="26EC0F9B44F06BA7" modified="2005-04-26" version="1">MSLHRFRNIDSSRPAYDRRDDRALYKPSSSRTPTLEEDIIPLTSSISISRNNSSKMKALDPRRLSMRLKRSSISPSPSPAPYDQHSTSTFHRTHPDSLPLPRHTSPSPSTRTEFIYKPIHQTDYTAVVAETATAQSRSASKYHYNHLPAGPASGKHMGRGNRVEERTISLQSRSRSRSRARPQARARYASYDEDEINAGDDLYDDMDGEYTSIARPGRDYSTELYTLTADKRCHRAARRLTTVMVPDAEDIYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BCX7</accession>
    <accession>C8VNA0</accession>
    <name>Q5BCX7_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_01603</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF85204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_659207.1">
        <property type="nucleotide sequence ID" value="XM_654115.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BCX7"/>
    <dbReference type="GeneID" id="2875248"/>
    <dbReference type="KEGG" id="ani:ANIA_01603"/>
    <dbReference type="HOGENOM" id="CLU_1885736_0_0_1"/>
    <dbReference type="InParanoid" id="Q5BCX7"/>
    <dbReference type="OrthoDB" id="4402936at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF85204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="135" mass="14922" checksum="D68174DE9D04F3B1" modified="2005-04-26" version="1">MTKELVSSSAANKALLNMFIAAELRYPVRQCAGARSVRRWEKTCGSVGTQLPSALLLYPVAIGILVVCVTLTRIARIREIYKGKGLEIPDDFDSTLTMPPVHFMQVSAPDDVDVNELRKVEVPGGLDIEILEFFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BED2</accession>
    <accession>C8VTK2</accession>
    <name>Q5BED2_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_01098</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF88149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_658702.1">
        <property type="nucleotide sequence ID" value="XM_653610.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BED2"/>
    <dbReference type="GeneID" id="2876867"/>
    <dbReference type="KEGG" id="ani:ANIA_01098"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN1098"/>
    <dbReference type="HOGENOM" id="CLU_2606007_0_0_1"/>
    <dbReference type="InParanoid" id="Q5BED2"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF88149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="79" mass="9041" checksum="DE4BB11ACB8EB3AF" modified="2005-04-26" version="1">MTKFDEVASCNERTHREKTEEPIRDSSLVIPLITQVDYVCYSLLGFDPLRTLMYGDVIEAPQPLSMNAVRMLDAPPWLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BEW1</accession>
    <accession>C8VUQ3</accession>
    <name>Q5BEW1_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ANIA_00919</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; UMP biosynthesis via de novo pathway.</text>
    </comment>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF88527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_658523.1">
        <property type="nucleotide sequence ID" value="XM_653431.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BEW1"/>
    <dbReference type="STRING" id="227321.Q5BEW1"/>
    <dbReference type="GeneID" id="2876696"/>
    <dbReference type="KEGG" id="ani:ANIA_00919"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN0919"/>
    <dbReference type="eggNOG" id="KOG1377">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047844_0_0_1"/>
    <dbReference type="InParanoid" id="Q5BEW1"/>
    <dbReference type="OMA" id="HRFLLWE"/>
    <dbReference type="OrthoDB" id="10263753at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004588">
        <property type="term" value="F:orotate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004590">
        <property type="term" value="F:orotidine-5'-phosphate decarboxylase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019856">
        <property type="term" value="P:pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006222">
        <property type="term" value="P:UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19278">
        <property type="entry name" value="OROTATE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19278:SF9">
        <property type="entry name" value="URIDINE 5'-MONOPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="188"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="198"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBF88527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="458" mass="50030" checksum="5FEEFCDF8ACA6AA8" modified="2005-04-26" version="1">MDSSTTSALPGNRLIAYIQSLAKAKKGLPYGLPVCVAPSHTVNSTDALLRLASLIGPYITILQVQADIIDDWSEDTIRQLTLLAKKYAFLIWEGGRILNATIGVVGRQRAESREVRNTLVDLIRKKYTKGVVKPASWANISTAWASGVAVNNQAADILIPTLKAAAREAVADAVQTIRTEITAVIDSNRPFSPHDSFGAQTNGETSHQRQPSHYAIGEGEHNSLALPPRKASTISLTRTITQHTEESTDALMGTESYEPEDVWDFGVAPPPTIDTDLPPPPLLARGILLCLPSATDSAFTPEYRKSTMAAAYANQDFVLGFICGEPWHLVSQRDDQILGFDALMDTLTPTEQDQLSHDMDGIEDTPSHPLALLSIIPHTLSSANDQQLGDTTPTTFETPEIPTDSLNPLAHRLYSLVGESVRARDACTSQREKSTRKQATKRSYRRPDLLHIPLVYLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BF01</accession>
    <accession>C8VPZ0</accession>
    <name>Q5BF01_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DUF1014 domain protein (AFU_orthologue AFUA_1G15390)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ANIA_00879</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCDC124 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF88603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_658483.1">
        <property type="nucleotide sequence ID" value="XM_653391.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BF01"/>
    <dbReference type="STRING" id="227321.Q5BF01"/>
    <dbReference type="GeneID" id="2876655"/>
    <dbReference type="KEGG" id="ani:ANIA_00879"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN0879"/>
    <dbReference type="eggNOG" id="KOG3223">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069723_1_1_1"/>
    <dbReference type="InParanoid" id="Q5BF01"/>
    <dbReference type="OMA" id="FEERMMP"/>
    <dbReference type="OrthoDB" id="76412at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010422">
        <property type="entry name" value="Ccdc124/Oxs1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054414">
        <property type="entry name" value="Ccdc124/Oxs1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054413">
        <property type="entry name" value="LSO1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21680">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21680:SF0">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06244">
        <property type="entry name" value="Ccdc124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22048">
        <property type="entry name" value="LSO1_2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LSO1/LSO2" evidence="5">
        <location>
            <begin position="11"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="Coiled-coil" evidence="4">
        <location>
            <begin position="115"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="13"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="28"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="73"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="136"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF22048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBF88603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="222" mass="24204" checksum="59FA37C06E657B05" modified="2005-04-26" version="1">MGGKKGGGENSKKAAGNARKAEAAANKKAIEDQKRAAEEDKQWAKGAKSSSKKEEAEAKKAEAARKKAERDALLAAEEASQPSKPKNNKSAAKKNAPSRGTLNLDQLDDAPSSRASALNASGIDNALDALSLTSKDTSKVDRHPERRYKAAYAAFEARRLPEIEAENPGLRRQQRIELVKKEFDKSPENPFNQVHVAFDASKEEIAAVREAERKKTEARLTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="119" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BFG3</accession>
    <accession>C8VRC2</accession>
    <name>Q5BFG3_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">histidinol-phosphate transaminase</fullName>
            <ecNumber evidence="4">2.6.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Imidazole acetol-phosphate transaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">ANIA_00717</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:23744"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57766"/>
            <dbReference type="ChEBI" id="CHEBI:57980"/>
            <dbReference type="EC" id="2.6.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 7/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.9" evidence="4"/>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF88925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_658321.1">
        <property type="nucleotide sequence ID" value="XM_653229.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BFG3"/>
    <dbReference type="FunCoup" id="Q5BFG3">
        <property type="interactions" value="200"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5BFG3"/>
    <dbReference type="GeneID" id="2876497"/>
    <dbReference type="KEGG" id="ani:ANIA_00717"/>
    <dbReference type="eggNOG" id="KOG0633">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_3_1_1"/>
    <dbReference type="InParanoid" id="Q5BFG3"/>
    <dbReference type="OMA" id="NFVQFGR"/>
    <dbReference type="OrthoDB" id="2015537at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004400">
        <property type="term" value="F:histidinol-phosphate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01023">
        <property type="entry name" value="HisC_aminotrans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005861">
        <property type="entry name" value="HisP_aminotrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01141">
        <property type="entry name" value="hisC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42885:SF2">
        <property type="entry name" value="HISTIDINOL-PHOSPHATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42885">
        <property type="entry name" value="HISTIDINOL-PHOSPHATE AMINOTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5 13" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="9" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="12">
        <location>
            <begin position="100"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CBF88925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="447" mass="48434" checksum="7D6BEB2AE71A07DB" modified="2005-04-26" version="1">MASRTTAFDLSKCARKNILKLQPYRCAREYVRPLTLPPQSAPKLINRTSDYKDDGTNVLLDANENAYGPGLALNSGGALQESAANGHSTGSSKPEIDLLGLNRYPDPHQHPLKQLFCNIRNTHTHTDKTITPENLFVGVGSDEAIDALLRAFCVPGKDKILTCPPTYGMYSVSADVNDVEIVKVPLDTDNGFALQPEKINAALSADPTIKLVYICSPGNPTATLVSKSDIQKVLEHPTWNGVVVLDEAYIDFAPEGSSLAEWVAEWPNLVVMQTLSKAFGLAGIRLGVAFTSPEIATLLNSLKAPYNISSPTSALAMAALGNPKNLEVMRSYRSKIIAQRDRILKELPSIPGIGRFRGGTESNFLLVEILDKPADQGGKPSNPVALATYEAMAEKRGVVVRFRGKELGCEGCLRITVGTEDEVTRFLEEIRHVLGGLLNGNEIASRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BGA0</accession>
    <accession>C8VTF3</accession>
    <name>Q5BGA0_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sin3 complex subunit (Stb2), putative (AFU_orthologue AFUA_1G04480)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_00430</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF89500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_658034.1">
        <property type="nucleotide sequence ID" value="XM_652942.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BGA0"/>
    <dbReference type="STRING" id="227321.Q5BGA0"/>
    <dbReference type="GeneID" id="2876208"/>
    <dbReference type="KEGG" id="ani:ANIA_00430"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN0430"/>
    <dbReference type="eggNOG" id="ENOG502QT8Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010065_0_0_1"/>
    <dbReference type="InParanoid" id="Q5BGA0"/>
    <dbReference type="OMA" id="AKFYQLY"/>
    <dbReference type="OrthoDB" id="19806at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070822">
        <property type="term" value="C:Sin3-type complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038919">
        <property type="entry name" value="STB2/STB2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059025">
        <property type="entry name" value="STB6_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31011">
        <property type="entry name" value="PROTEIN STB2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31011:SF2">
        <property type="entry name" value="PROTEIN STB2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25995">
        <property type="entry name" value="STB6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STB6-like N-terminal" evidence="2">
        <location>
            <begin position="46"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="442"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="534"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="599"/>
            <end position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF89500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="845" mass="94125" checksum="EB9CCFBFB8352187" modified="2005-04-26" version="1">MSSTASGAQAASPTTNRETTRASVNAAENPSTKPHGAELPPRRGHQKIVFTDPVALRYLEEDPSTVVLHRRLALEGYEIYIVEQWACSRIHPTFVITTFTGDSSHKVVAGVLGVPTDESTWSPRLKLYFNAVKRFQLREKETPLGTVMVTDLNSFPSGLSVIAVPDGDILKHREDFVVNENLKRLGCAGRAGLKLQEPAPATVAKFHQLYRTSERIPLYSAVVELVKQCQIALMMFGKLAPEYVDGLLCDVTEDAVGDWWTDFGMDLYNIEPSDGKLGPTTVAALLGTLMGARNRLHASGAPVGKDAFDIVNLKRGIGSFQKSQKIERTRRLDRHTLDRLHRVTAKAANAEGWTDAVKSTMAELSGHGGEMVMGMVRGKEKGGIADIETIDIDNFAQLISGERAKWLWRGKPRKSTVESNGPPAADMMFTTDEQGGYVWTSRKRHSHEDLGMEPSFQRSERSWKQAEAAGLPEDKDQNLSRMVMKGVSEKVSDARIGFGKFKDAVGIPGLRSHKAKDGSEFGGDAAQLALMESETETGPWPNHEDAPLPETHISNDGEMGEQPLSTADQPAEKSPPAITVESAAPNEDTETSRKASVSRTDEEMHDLDLFKTRSTDASAVSGDQERAPTPASCAMVLRRPHSCDELYSDDSFERRNEYWPRHLSFSIVEEVVLVRKGLDDRTIFESSDATLEEAIVHEDVLASDARISRARIRDLELNTVPWVESQVSSVDRLNHTLYETHEKMSSKYLERFELYQQVRERSGNVLAAEHSQLTEHMKRVEMLGAKLDYELHALETKVEDVETGLGEFERHVNEIELRVKSLIRGEKKQNYSWLSWLSRLGGHWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="126" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BGF4</accession>
    <accession>C8VTQ7</accession>
    <name>Q5BGF4_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="2">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">ANIA_00376</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.49" evidence="2"/>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF89606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_657980.1">
        <property type="nucleotide sequence ID" value="XM_652888.2"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q5BGF4">
        <property type="interactions" value="22"/>
    </dbReference>
    <dbReference type="GeneID" id="2876154"/>
    <dbReference type="KEGG" id="ani:ANIA_00376"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN0376"/>
    <dbReference type="eggNOG" id="KOG0017">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000384_38_1_1"/>
    <dbReference type="InParanoid" id="Q5BGF4"/>
    <dbReference type="OMA" id="CESTINP"/>
    <dbReference type="OrthoDB" id="4499277at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000063">
        <property type="entry name" value="Zinc knuckle domaincontaining protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="12">
        <location>
            <begin position="582"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="domain" description="Chromo" evidence="11">
        <location>
            <begin position="1303"/>
            <end position="1363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="152"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="363"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="106"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="157"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="179"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CBF89606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="1376" mass="157740" checksum="9D91886D2424F368" modified="2005-04-26" version="1">MTIVGLIKGVLLWRKIQPCFPIFPHTTWVSELDSTPVTKTQGSASYTKRCCYGSFAYTRTLDLSDSAKACAVLKAVSHLQDFLTTTILLSPFFFSDSFLMRRPFTMTMEEESVTLLLQQLQELRTEMRTQKQQLQEENNSLRAELQAVRNSQLRNHPPVTTTVTSATPTPYERSYPRPRHPDVEPFTGEDPKDYPPFQMNLLYYAYSRMRGKASQRVLPWLLARQKSETPVLWAEFSAVLDKAFGDPDRQRKALVRVNTIKQGRRDFEEFLNEFDEELLNAGGINWDDNQKKALLDTAINVELLKAMGWLTRKGSHAAVPMHVARTRPAGGSDRTGTPDQMDWEATHAQIAALQKEVAALRMKGTRTPRKASQAPAEEKQKRLSEGKCLRCGDPDHFVQLDIGAHTEKGAYFYVIPDNLGYDLILGLPWLEQHDGRLEAKRGRLYLRTTGVRLWSTTKRPLPKLDIAQISAATMGGFIQRKRCHGQDIEIFAVSLADIQKALAPKRHIDPRTKLPRQYWKYLRLFEQDKAEELPPHRGDGIDHKIELVREESGKDPEVPWGPLYNMTQEELIVLRKTLSELLQKGFIRVSHSPAAAPVLFVRKPGGGLRFCVDYRALNAITKKDRYPLPLIHETLNQIGQARWFTKLDVSAAFHKIRIAKGQEWMTAFRTRYGLFEWLVTPFGLANAPSTFQKYINWTLREYLDEFCSAYIDDVLVYTNGDLRQHRKHVRMVLKKLEEAGLYLDIKKCEFECKETKYLGFIIQAGKGIKMDPEKVKAIKEWETPTTIKGVRGFLGFANFYRRFIPNFSGIKGTPFLWTKECQDSFDLLKEKFITGPVLATFNPSYRTVVETDSSGYNTGGVLSQYNEKGELHPCAYFSKRNSPAECNYEIYDKELLAIVRCLEAWDAELRSCGEFQVITDHKNLEYFFSPRKLTERHVRWSLFLSRFNFKLVYRKGSANQRADALSRRDQDMPDDKDDRVKSRTMQLFSKKHLGKMVVATLQPTGEPPREPCEKGDMWKEALKQDKGYNGAIQCLKDGARKFPPHLQLKVGTSECQLDAQGYILFRGRRWVPGSEQLRTNIIQAAHDSMLTGHPGREQTYMLVSRINRRLSTAHHPQTDGSTERMNSTVETYLRIYTCYDQRDWNRLLPLAELAINGPLPEEVEQLAEEPAKSPIQKGEAIVRKVKEALDWAQASMAYSQQNAENQANKHRSPATNYQVGDKVWLSLKNICTDRPSKKLDWKNAKYEVIGLVGSHAVRLNTPPGIHPVFHVDLLRLASSDPLPSQKNDDTQPPGIIVNGEKEYMVEKILDERPRRYGRGHRLEYLVKWSGYARPTWEAATALEEAQALDEWLDRTKQYRLQDGSLNRDAYIKAKAT</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2016-09-07" modified="2026-01-28" version="122" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BH33</accession>
    <accession>C8VQ69</accession>
    <name>MDPD_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">FAD-dependent monooxygenase mdpD</fullName>
            <ecNumber evidence="10">1.-.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Monodictyphenone synthesis protein D</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">mdpD</name>
        <name type="ORF">AN0147</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2010" name="Appl. Environ. Microbiol." volume="76" first="2067" last="2074">
            <title>Characterization of the Aspergillus nidulans monodictyphenone gene cluster.</title>
            <authorList>
                <person name="Chiang Y.M."/>
                <person name="Szewczyk E."/>
                <person name="Davidson A.D."/>
                <person name="Entwistle R."/>
                <person name="Keller N.P."/>
                <person name="Wang C.C."/>
                <person name="Oakley B.R."/>
            </authorList>
            <dbReference type="PubMed" id="20139316"/>
            <dbReference type="DOI" id="10.1128/AEM.02187-09"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2011" name="J. Am. Chem. Soc." volume="133" first="4010" last="4017">
            <title>Genome-based deletion analysis reveals the prenyl xanthone biosynthesis pathway in Aspergillus nidulans.</title>
            <authorList>
                <person name="Sanchez J.F."/>
                <person name="Entwistle R."/>
                <person name="Hung J.H."/>
                <person name="Yaegashi J."/>
                <person name="Jain S."/>
                <person name="Chiang Y.M."/>
                <person name="Wang C.C."/>
                <person name="Oakley B.R."/>
            </authorList>
            <dbReference type="PubMed" id="21351751"/>
            <dbReference type="DOI" id="10.1021/ja1096682"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2012" name="ChemBioChem" volume="13" first="1680" last="1688">
            <title>Genetic and biosynthetic studies of the fungal prenylated xanthone shamixanthone and related metabolites in Aspergillus spp. revisited.</title>
            <authorList>
                <person name="Simpson T.J."/>
            </authorList>
            <dbReference type="PubMed" id="22730213"/>
            <dbReference type="DOI" id="10.1002/cbic.201200014"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2020" name="Microorganisms" volume="8" first="0" last="0">
            <title>Genome Wide Analysis Reveals the Role of VadA in Stress Response, Germination, and Sterigmatocystin Production in Aspergillus nidulans Conidia.</title>
            <authorList>
                <person name="Son Y.E."/>
                <person name="Park H.S."/>
            </authorList>
            <dbReference type="PubMed" id="32872591"/>
            <dbReference type="DOI" id="10.3390/microorganisms8091319"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="4 5 6 11">FAD-dependent monooxygenase; part of the gene cluster that mediates the biosynthesis of monodictyphenone, a prenyl xanthone derivative (PubMed:20139316, PubMed:21351751, PubMed:22730213). MdpD does not seem to be required for the biosynthesis of emodin or monodictyphenone, but seems to be involved in a branching pathway between chrysophanol and shamixanthone; and more particularly in the conversion of arugosin I into arugosin H (PubMed:20139316, PubMed:21351751, PubMed:22730213). The pathway begins with the synthesis of atrochrysone thioester by the polyketide synthase (PKS) mdpG. The atrochrysone carboxyl ACP thioesterase mdpF then breaks the thioester bond and releases the atrochrysone carboxylic acid from mdpG. The atrochrysone carboxylic acid is then converted to atrochrysone by mdpH-1 which is further transformed into emodin anthrone. The next step is performed by the anthrone oxygenase mdpH-2 that catalyzes the oxidation of emodinanthrone to emodin. Emodin is further modified to yield monodictyphenone via several steps involving mdpB, mdpC and mdpL. Mdpj and mdpK are part of a branching pathway leading to arugosin F, which is further converted to shamixanthone and epishamixanthone via several intermediates including arugosins I, H, A, B or variecoxanthone A. These reactions are performed by the FAD-dependent monooxygenase mdpD, the xanthone prenyltransferases xptA and xptB and the dehydrogenase xptC.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="induction">
        <text evidence="7">Expression is negatively regulated by the spore-specific regulatory gene vadA in conidia.</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="4 5 6">Impairs the production of monodictyphenone, but still enables the synthesis of intermediates until emodin.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="10"/>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF90103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AACD01000005">
        <property type="protein sequence ID" value="EAA66020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_657751.1">
        <property type="nucleotide sequence ID" value="XM_652659.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BH33"/>
    <dbReference type="SMR" id="Q5BH33"/>
    <dbReference type="STRING" id="227321.Q5BH33"/>
    <dbReference type="EnsemblFungi" id="CBF90103">
        <property type="protein sequence ID" value="CBF90103"/>
        <property type="gene ID" value="ANIA_00147"/>
    </dbReference>
    <dbReference type="KEGG" id="ani:ANIA_00147"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN0147"/>
    <dbReference type="eggNOG" id="KOG2614">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009665_19_1_1"/>
    <dbReference type="InParanoid" id="Q5BH33"/>
    <dbReference type="OMA" id="ANESWVP"/>
    <dbReference type="OrthoDB" id="16820at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900815">
        <property type="term" value="P:monodictyphenone biosynthetic process"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF315">
        <property type="entry name" value="FAD-DEPENDENT MONOOXYGENASE MDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-0274">FAD</keyword>
    <keyword id="KW-0285">Flavoprotein</keyword>
    <keyword id="KW-0503">Monooxygenase</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000437106" description="FAD-dependent monooxygenase mdpD">
        <location>
            <begin position="1"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="23"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="244"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="271"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="369"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="382"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="B8M9J8"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="L0E4H0"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="20139316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="21351751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="6">
        <source>
            <dbReference type="PubMed" id="22730213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="7">
        <source>
            <dbReference type="PubMed" id="32872591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="8">
        <source>
            <dbReference type="PubMed" id="20139316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="9"/>
    <evidence type="ECO:0000305" key="10">
        <source>
            <dbReference type="PubMed" id="20139316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="11">
        <source>
            <dbReference type="PubMed" id="22730213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAA66020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005890"/>
        </source>
    </evidence>
    <sequence length="521" mass="57864" checksum="352125DD929A214A" modified="2005-04-26" version="1">MTHFPVNIASDKQEFDPERWAKTPTTESSVNGENGTAPTSGLPSRHPSTGISVLIVGAGMGGLMTALECWRKGHDVAGILERSEGPVYSGDIIVMQPSAVSIIRHWPDMLHDMKAEQVHAVVSYETHDGRHIYGPTVPSFNDPEHLETRKGPFVAPAQVRRKFYRMLLRQVARCGLRVEYGKTVKSYFEDEKDGKGGVIIATTGEAEVRVADIVVAADGLKSPSEILIAGQHVPPRSSGLSIYRTAFPKDLAMQNELVRKRWSDSPPIWEYWLGPGMYLGVFVGDDIISFGFTPRDDIVEGTATESWEPDTDPETVAQAMLSGAGDWDPAVLALIRSAPKGAIVHWPLLWRDLRREWTSPAGRVVQVGDSAHSFIPTSGNGGSQALEDAITLATCLQLAGSSQRAYLGTKIYNLLRYERVSCAQKMSFVNSQLKTGTDWDAIWKDPAKIRTRFPKWIFQHDPEAYAYEKFGEAFAHLLDGREFVNTNYPPGHEFRAWTVEEVWRNIADGKRVEDLLDGDWS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2020-10-07" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1U8QTJ9</accession>
    <accession>C8V0E1</accession>
    <accession>Q5AZ37</accession>
    <name>CICA_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ABC-type transporter cicA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Cichorine biosynthesis cluster protein A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">cicA</name>
        <name type="ORF">AN6443</name>
        <name type="ORF">ANIA_06443</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2012" name="J. Am. Chem. Soc." volume="134" first="8212" last="8221">
            <title>Illuminating the diversity of aromatic polyketide synthases in Aspergillus nidulans.</title>
            <authorList>
                <person name="Ahuja M."/>
                <person name="Chiang Y.M."/>
                <person name="Chang S.L."/>
                <person name="Praseuth M.B."/>
                <person name="Entwistle R."/>
                <person name="Sanchez J.F."/>
                <person name="Lo H.C."/>
                <person name="Yeh H.H."/>
                <person name="Oakley B.R."/>
                <person name="Wang C.C."/>
            </authorList>
            <dbReference type="PubMed" id="22510154"/>
            <dbReference type="DOI" id="10.1021/ja3016395"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2012" name="Med. Chem. Commun." volume="3" first="0" last="0">
            <title>Identification and molecular genetic analysis of the cichorine gene cluster in Aspergillus nidulans.</title>
            <authorList>
                <person name="Sanchez J.F."/>
                <person name="Entwistle R."/>
                <person name="Corcoran D."/>
                <person name="Oakley B.R."/>
                <person name="Wang C.C."/>
            </authorList>
            <dbReference type="PubMed" id="24244835"/>
            <dbReference type="DOI" id="10.1039/c2md20055d"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2019" name="Molecules" volume="24" first="0" last="0">
            <title>Discovery of three new phytotoxins from the fungus Aspergillus nidulans by pathway inactivation.</title>
            <authorList>
                <person name="Liao L."/>
                <person name="Zhang X."/>
                <person name="Lou Y."/>
                <person name="Zhou C."/>
                <person name="Yuan Q."/>
                <person name="Gao J."/>
            </authorList>
            <dbReference type="PubMed" id="30708999"/>
            <dbReference type="DOI" id="10.3390/molecules24030515"/>
        </citation>
        <scope>BIOTECHNOLOGY</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2025" name="Org. Biomol. Chem." volume="23" first="2721" last="2725">
            <title>Overexpression of a pathway-specific transcriptional factor CicD leads to the discovery of new phytotoxins in Aspergillus nidulans.</title>
            <authorList>
                <person name="Liu X."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Yu J."/>
                <person name="Hou X."/>
                <person name="Zhou L."/>
                <person name="Zhang F."/>
                <person name="Che Q."/>
                <person name="Zhu T."/>
                <person name="Li D."/>
                <person name="Zhang G."/>
            </authorList>
            <dbReference type="PubMed" id="39964146"/>
            <dbReference type="DOI" id="10.1039/d4ob02051k"/>
        </citation>
        <scope>BIOTECHNOLOGY</scope>
    </reference>
    <comment type="function">
        <text evidence="6 11">ABC-type transporter; part of the gene cluster that mediates the biosynthesis of cichorine and its derivatives 8-methoxycichorine, 8-epi-methoxycichorine, N-(4'-carboxybutyl) cichorine, isoleucylcichorine and leucylcichorine; phytotoxins active against knapweed, corn, and soybeans (PubMed:24244835). CicA is probably involved in the secretion of the products of the cluster.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="6">Abolishes the production of cichorine.</text>
    </comment>
    <comment type="biotechnology">
        <text evidence="7 8">Cichorine and its derivatives are promising in the course of developing novel herbicides.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF69461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AACD01000108">
        <property type="protein sequence ID" value="EAA58465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_664047.1">
        <property type="nucleotide sequence ID" value="XM_658955.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1U8QTJ9"/>
    <dbReference type="SMR" id="A0A1U8QTJ9"/>
    <dbReference type="FunCoup" id="A0A1U8QTJ9">
        <property type="interactions" value="247"/>
    </dbReference>
    <dbReference type="GlyCosmos" id="A0A1U8QTJ9">
        <property type="glycosylation" value="6 sites, No reported glycans"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CBF69461">
        <property type="protein sequence ID" value="CBF69461"/>
        <property type="gene ID" value="ANIA_06443"/>
    </dbReference>
    <dbReference type="GeneID" id="2871340"/>
    <dbReference type="KEGG" id="ani:ANIA_06443"/>
    <dbReference type="eggNOG" id="KOG0054">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_27_1_1"/>
    <dbReference type="InParanoid" id="A0A1U8QTJ9"/>
    <dbReference type="OMA" id="QVTDAWT"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062032">
        <property type="term" value="P:cichorine biosynthetic process"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd18597">
        <property type="entry name" value="ABC_6TM_YOR1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18606">
        <property type="entry name" value="ABC_6TM_YOR1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000565">
        <property type="entry name" value="ABC bile acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002040">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000010">
        <property type="entry name" value="Multidrug resistance-associated ABC transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF464">
        <property type="entry name" value="ABC-TYPE TRANSPORTER CICA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000450883" description="ABC-type transporter cicA">
        <location>
            <begin position="1"/>
            <end position="1396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1 3">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1 3">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1 3">
        <location>
            <begin position="300"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1 3">
        <location>
            <begin position="324"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1 3">
        <location>
            <begin position="409"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1 3">
        <location>
            <begin position="440"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1 3">
        <location>
            <begin position="816"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1 3">
        <location>
            <begin position="852"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1 3">
        <location>
            <begin position="930"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1 3">
        <location>
            <begin position="951"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1 3">
        <location>
            <begin position="1036"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1 3">
        <location>
            <begin position="1065"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1 1" evidence="3">
        <location>
            <begin position="143"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter 1" evidence="2">
        <location>
            <begin position="525"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1 2" evidence="3">
        <location>
            <begin position="816"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter 2" evidence="2">
        <location>
            <begin position="1131"/>
            <end position="1380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="510"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="751"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="18"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="510"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="757"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="563"/>
            <end position="570"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="1165"/>
            <end position="1172"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="4">
        <location>
            <position position="321"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="4">
        <location>
            <position position="604"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="4">
        <location>
            <position position="880"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="4">
        <location>
            <position position="1096"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="4">
        <location>
            <position position="1150"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="4">
        <location>
            <position position="1154"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="6">
        <source>
            <dbReference type="PubMed" id="24244835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="7">
        <source>
            <dbReference type="PubMed" id="30708999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="8">
        <source>
            <dbReference type="PubMed" id="39964146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="9">
        <source>
            <dbReference type="PubMed" id="24244835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="10"/>
    <evidence type="ECO:0000305" key="11">
        <source>
            <dbReference type="PubMed" id="24244835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAA58465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005890"/>
        </source>
    </evidence>
    <sequence length="1396" mass="155892" checksum="F4A720ACD473A5B6" modified="2017-05-10" version="1">MRLSSEAKIAESGGQPPTAGSRSETGSESTEAESADPKAQKWYQRSLNPLRWQKIPPVPEERTVSREYGASFFSIASFQWMAPLMKVGYLRPLELQDIWTVNPDREVDVLTKRFEVSLEKRTNAGAKRPLLWALYDTFRFEFLLGGFCHLISSLLIVFAPYLTRYQIAFATEAYVAQRSGQPAPRIGRGMGFVVGITVMQAIQSLCTNQFLYRGQMVGGQIRAVLILQIFNKAMKLSGRAKAGGVQSPEQQEKIKELKAAKDQALKKPGSPPADDKGWGNGRIVALMSIDVDRINLACGMFHISWTAPVSIIVALILLLVNLTYSALAGFGLLVIGMPFLTYAVRFLFKRRRNINKLTDQRVSLTQEILQGVRFVKFFGWESSFLDRLKEIRHHEIRSIQTLLAVRNGILCVSMAIPVFASMLSFITYALSNHVLDPAPIFSSLALFNSLRMPLNLLPLVLGQITDAWTALNRIQEFIVAEEQKEDIERDEHMPEAVRMDRASFTWERKAADKEAEKVEKKANPRRTEPKSEAPTDSAESDEPFQLRDMTLDIRRDELVAVIGTVGSGKSSLLAALAGDMRLTDGSVRLSTSRAFCPQYTWIQNTSLRDNILFGKDYDEKWYDQVIDACALKPDLEILPNGDATEIGERGITISGGQKQRLNIARAIYFNAELVLLDDPLSAVDAHVGRHIMDKAICGLLKGRCRILATHQLHVLSRCDRIVVMDDGRIHAVGTFDELSRDNDLFKQLMSTASQDSKEDEEEATEVVEEEAEKQAQQEPTKPAAALMQQEEKATDSVGWTVWKAYIRASGSYFNALAILFLLAFANVVNVWTNLWLSYWTSNHYPSLSTGQYIGIYAGLGAGSALTMFIFSTYMSTAGTNASRQMLQLAMTRVLRAPMSFFDTTPLGRITNRFSKDIGVMDNELCDAMRMYAITITMIVSIMILIIVFYHYFAIALVPLFLLFLTASNYYRSSAREMKRHESILRSAVYARFSEAITGTASIRAYGVQNQFRSSLRDSVDTMNGAYFLTFSNQRWLSVRLDAVAVLLVFVTGVLVVTSRFDVSPSISGLVLSYILAIAQMLQFTVRQLAEVENNMNATERVHYYGTQLEEEAPAHIPSNPVPESWPPHGEITFDNVAMRYRPGLPLVLKNLSMNISGGERIGIVGRTGAGKSSIMSALFRLTELSSGRITIDGVDISTIGLHDLRSRLAIIPQDPTLFRGSIRSNLDPFNEHSDLELWDALRKAHLIDSDTKDSAVDASNPNGNANAQRLTLDTAVDEEGLTFSLGQRQLMALARALVRNARIIICDEATSSVDFATDQRIQETMAQGFEGKTLLCIAHRLKTIIHYDRICVMDQGSIAEIDTPLNLWEKEDGIFRAMCERSGISREDIVGQVEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>C8V0M4</accession>
    <name>C8V0M4_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS multidrug transporter, putative (AFU_orthologue AFUA_2G00780)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ANIA_06412</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF69522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050466929.1">
        <property type="nucleotide sequence ID" value="XM_050613244.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V0M4"/>
    <dbReference type="GeneID" id="2871308"/>
    <dbReference type="KEGG" id="ani:ANIA_06412"/>
    <dbReference type="eggNOG" id="KOG3764">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_51_1_1"/>
    <dbReference type="InParanoid" id="C8V0M4"/>
    <dbReference type="OMA" id="MSGINNT"/>
    <dbReference type="OrthoDB" id="5086884at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050930">
        <property type="entry name" value="MFS_Vesicular_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506">
        <property type="entry name" value="GH10249P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506:SF35">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="145"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="208"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="246"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="294"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="322"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="1"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBF69522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="360" mass="38726" checksum="BE4BE69C5BC66A5A" modified="2009-11-03" version="1">MAGQILQSIASASVWIVAFATLVDNVDERSKGKVTATAMSFISMGIFAGPMVSGFLLELVGYWPAWFAALLLLVVDFLARLLMIETPSARKSESASDAQEQSPLLAASSGQTAQDHENETGTAAGDAKSAASRGFYRIMLTNPQILASMFNTLALSLTLASFDTTLPLHVRDVFGWGSLPVGLIFFCLQIPTIALGPGVGWLRDRIGLRYPTTVSCGLLAPLLWLLSVPGEEFPWGKLGGDKTGQVVYILAIVGIGFCLAFTRGAGTFQMMAVIHELERDNPSMFGPHGGNSRLSGLIELPFNIGMMVGPLLSGSFSEYLGYYWTCFVLAVIAMLVAISSWLYLTAQGQDVREMEEEGMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2025-10-08" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>C8V131</accession>
    <name>C8V131_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Acyl-CoA dehydrogenase NM domain-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ANIA_10834</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF71062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_664199.2">
        <property type="nucleotide sequence ID" value="XM_659107.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V131"/>
    <dbReference type="STRING" id="227321.C8V131"/>
    <dbReference type="GeneID" id="2870662"/>
    <dbReference type="KEGG" id="ani:ANIA_10834"/>
    <dbReference type="eggNOG" id="KOG1469">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018204_1_2_1"/>
    <dbReference type="InParanoid" id="C8V131"/>
    <dbReference type="OMA" id="WNMFLSK"/>
    <dbReference type="OrthoDB" id="434771at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050741">
        <property type="entry name" value="Acyl-CoA_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083:SF32">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE NM DOMAIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083">
        <property type="entry name" value="MEDIUM-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="9">
        <location>
            <begin position="35"/>
            <end position="155"/>
        </location>
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    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="8">
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            <begin position="209"/>
            <end position="279"/>
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    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="7">
        <location>
            <begin position="291"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBF71062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="488" mass="54033" checksum="1B51091FD5A111FF" modified="2009-11-03" version="1">MDPYRGPAPKGHIPASQRIPAIARPFVSARALKTLDAVEKFVEEECIPADAVYNQALGETTQERFSAHPQIMEDLKTKAKQLGLWNMFLPKNHFSEGAGYSNLEYGLMAEYLGRSLTASEATNCAAPDTGNMEVFAKYGTEEQKKKWLRPLLDGEIRSGFLMTEPQVASSDATNIELNMKKDGDYFILNGQVGLLCSIFRTGYSNGRLQKWWASGVGDLRTKVFLVMGKSDPANPNKYKQQTVIAVPSDTPGITIKRMLSVLGYDDAPHGHGHVFFDNVRVHKSNVILGEGRGFEVVQGRLGPGRIHHAMRSVGAAEKALEYFLARVNDPRKRPFGKQLSEHGIMLERIARSRIEIDAARLAVLNAAIMIDQGDAKHALKEIAEVKVQVPRMLQEIIDRAIQAYGAGGVSQDTPLANMSSGARTMRIVDGPDEVHMLQLGRNENKRGKALLGKIEAQKQKTQALLKQYNMQERDILQLDRRSGTSAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>C8V199</accession>
    <name>C8V199_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">AcuM, Zn(II)2Cys6 transcription factor involved in transcription control of gluconeogenisis (Eurofung)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ANIA_06293</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF69765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050466945.1">
        <property type="nucleotide sequence ID" value="XM_050611369.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V199"/>
    <dbReference type="FunCoup" id="C8V199">
        <property type="interactions" value="391"/>
    </dbReference>
    <dbReference type="STRING" id="227321.C8V199"/>
    <dbReference type="GeneID" id="2870974"/>
    <dbReference type="KEGG" id="ani:ANIA_06293"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN6293"/>
    <dbReference type="eggNOG" id="ENOG502QQGC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010748_0_0_1"/>
    <dbReference type="InParanoid" id="C8V199"/>
    <dbReference type="OMA" id="TRCVKRN"/>
    <dbReference type="OrthoDB" id="65716at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015976">
        <property type="term" value="P:carbon utilization"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045722">
        <property type="term" value="P:positive regulation of gluconeogenesis"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.240.10:FF:000002">
        <property type="entry name" value="Zn cluster transcription factor Rds2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056751">
        <property type="entry name" value="PAS_13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053045">
        <property type="entry name" value="Zinc_cluster_trans_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31986">
        <property type="entry name" value="REGULATOR OF DRUG SENSITIVITY 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31986:SF7">
        <property type="entry name" value="REGULATOR OF DRUG SENSITIVITY 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24990">
        <property type="entry name" value="PAS_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="75"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="104"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="162"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
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            <begin position="271"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="35"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="48"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="175"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="271"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="286"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBF69765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="522" mass="58261" checksum="75286A275039411B" modified="2009-11-03" version="1">MTEKNTTQPGSAPDQYAGNGTAENTGPSKTLDGNKVGRVDSNAKENAQKSPASKTESTPAGTRTSPKKRRKVNHACVYCRRSHMTCDSERPCTRCIKRNIGHLCHDEPREPSKRSRSEHEQSAADEEGSSNNEYSKVHAMPRKVDIQDAAGQQILADGSLGLTPSSMNAVQPGPMSSSTSQNMSVTSQQQLLGYNDWVGGQNQFQDMHTFHPSYMFNAPEVTNEYNLLGDFLSNSLLDDGSIFQNEDMQRMYSDPTLINSMAVLGGPSTSLLQQSQTLQPQQSQQNQGDTASGATIGNDKARETYYMTAADPAGSDPPEERMNKLLKAKYDAGLLRPFNYVKGYARLSAYMEKNLQVSSRQKIARQLDKFRPKFRDRMQKLTDIELILVEMWFERSLMEYDRVFASMAIPACCWRRTGEIFRGNKEMAELIGVPIELLRDGKLAIHEIIVEDQLVSYWEKFGAIAFDNTQKAMLTSCTLKNPNATSPTEGIPCCFSFTIRRDNHNIPSLIVGNFLPTQRDTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>C8V1I2</accession>
    <name>C8V1I2_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_10802</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF69832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050466951.1">
        <property type="nucleotide sequence ID" value="XM_050611486.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V1I2"/>
    <dbReference type="GeneID" id="74896610"/>
    <dbReference type="KEGG" id="ani:ANIA_10802"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN10802"/>
    <dbReference type="HOGENOM" id="CLU_2638058_0_0_1"/>
    <dbReference type="InParanoid" id="C8V1I2"/>
    <dbReference type="OrthoDB" id="4093673at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057394">
        <property type="entry name" value="PIGBOS1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23670">
        <property type="entry name" value="PIGBOS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF69832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="77" mass="8210" checksum="68F532E262C4F3B0" modified="2009-11-03" version="1">MSRNFIPVVLAVVMGVGTGYYTFQPALRELQSNKGIIARSPSGSQSFPAAQQPEHQSQQTVSTLTSTPTPTESNTGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2025-10-08" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>C8V1J1</accession>
    <name>C8V1J1_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Phenylalanine--tRNA ligase, mitochondrial</fullName>
            <ecNumber evidence="3">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Phenylalanyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">ANIA_06253</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="19">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Is responsible for the charging of tRNA(Phe) with phenylalanine in mitochondrial translation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>tRNA(Phe) + L-phenylalanine + ATP = L-phenylalanyl-tRNA(Phe) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="3"/>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF69850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_663857.2">
        <property type="nucleotide sequence ID" value="XM_658765.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V1J1"/>
    <dbReference type="FunCoup" id="C8V1J1">
        <property type="interactions" value="739"/>
    </dbReference>
    <dbReference type="STRING" id="227321.C8V1J1"/>
    <dbReference type="GeneID" id="2871038"/>
    <dbReference type="KEGG" id="ani:ANIA_06253"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN6253"/>
    <dbReference type="eggNOG" id="KOG2783">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022696_0_1_1"/>
    <dbReference type="InParanoid" id="C8V1J1"/>
    <dbReference type="OMA" id="PISHYPQ"/>
    <dbReference type="OrthoDB" id="4457at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070156">
        <property type="term" value="P:mitochondrial phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00496">
        <property type="entry name" value="PheRS_alpha_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.380:FF:000002">
        <property type="entry name" value="phenylalanine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000053">
        <property type="entry name" value="Phenylalanyl-tRNA synthetase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.380">
        <property type="entry name" value="Ferrodoxin-fold anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005121">
        <property type="entry name" value="Fdx_antiC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036690">
        <property type="entry name" value="Fdx_antiC-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004530">
        <property type="entry name" value="Phe-tRNA-synth_IIc_mito"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002319">
        <property type="entry name" value="Phenylalanyl-tRNA_Synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00469">
        <property type="entry name" value="pheS_mito"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538:SF41">
        <property type="entry name" value="PHENYLALANINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03147">
        <property type="entry name" value="FDX-ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01409">
        <property type="entry name" value="tRNA-synt_2d"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00896">
        <property type="entry name" value="FDX-ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54991">
        <property type="entry name" value="Anticodon-binding domain of PheRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51447">
        <property type="entry name" value="FDX_ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="16">
        <location>
            <begin position="112"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="FDX-ACB" evidence="17">
        <location>
            <begin position="412"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="58"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00057761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00073229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CBF69850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="516" mass="58533" checksum="B1C4468F6F2BF08C" modified="2009-11-03" version="1">MRLFATSRALRLGSGRWSITSARSSIRLPLSQLLRAGSVGHREWSSTVIRRTQHTINKSESTATTPSASPKSLTVGGKAYPIDDWTNTPDTILAHIDRRLYLDDSHPLAITRKLIESQFPRPVYGNYSEKDPIVTTAQNFDVLGFPADHPGRSRTDTYYLNEKTVLRTHTSAHQQAYFQQISRNEETRPEEVGYTVVADVYRRDAIDRSHYPVFHQMEGAMLWKRPADKPLEHAKQTAAAIMKDVYSIPSHSVPVEDPNPTIHPQRNPLQADYHSEEEVEAIAAHLKRSLERMVIKVFSEAQKASAASEGAEAETLRVRWVEAYFPFTSPSWELEVFWQGDWLEILGCGVVKQELLNNSDVPNRVGWAFGLGLERIAMLLFNIPDIRLFWSKDERFLSQFKAGQITRFEPFSKYPACYKDVAFWLPSAATSGGSAAGGAVPVHENDIMEIVRGVGGNLVEDVKLIDEFIHPKTNRKSLCYRINYRSLERTLTNEETNDLHDKVRQKLVSQLCVELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2025-10-08" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>C8V1S4</accession>
    <name>C8V1S4_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphatidylinositol 4-kinase</fullName>
            <ecNumber evidence="7">2.7.1.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ANIA_10791</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19877"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58178"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.67"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="7">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Vacuole membrane</location>
            <topology evidence="7">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the PI3/PI4-kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.67" evidence="7"/>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF69919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_663826.2">
        <property type="nucleotide sequence ID" value="XM_658734.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V1S4"/>
    <dbReference type="FunCoup" id="C8V1S4">
        <property type="interactions" value="240"/>
    </dbReference>
    <dbReference type="STRING" id="227321.C8V1S4"/>
    <dbReference type="GeneID" id="2870813"/>
    <dbReference type="KEGG" id="ani:ANIA_10791"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN10791"/>
    <dbReference type="eggNOG" id="KOG2381">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009049_2_0_1"/>
    <dbReference type="InParanoid" id="C8V1S4"/>
    <dbReference type="OMA" id="NWMVKVD"/>
    <dbReference type="OrthoDB" id="3349449at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004430">
        <property type="term" value="F:1-phosphatidylinositol 4-kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039756">
        <property type="entry name" value="Lsb6/PI4K2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12865:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-KINASE TYPE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12865">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-KINASE TYPE-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="9">
        <location>
            <begin position="172"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="314"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="422"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="613"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="649"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="72"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="344"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="444"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="616"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="665"/>
            <end position="676"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBF69919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="775" mass="88969" checksum="F34396C45980D3EA" modified="2009-11-03" version="1">MPKNNRPATSGYARLAQEEEDRHNDPYEYSDDDDLYHTSSTVNPYGTHYEPISTRGSMPPGVATTPPEYRRRSSVQHRRGRRNSAVDIKAINARLERWAEEFASKFKIHRVKGKTLEEEKLEIYHSVFQPPNGVRPITAEELDSEEAEMATRKAREGFEEVVESVRLAIELGVHPRMISQGSSGSYFARNSEGKVVGVFKPKDEEPYASRNPKWTKWIHRNLFPCFFGRACLIPNLSYVSEAAAYVLDSRLRTNMVPYTDIVWLSSKSFYYDFWDRRKAWMGKKPLPPKAGSFQVFLKGYKDANLFLREHPWPDQTNTGFRAQDAPKRKKRPWNEACRPSGIQSDDEDEGEEDEDYHARTPSPQEESRERRFYWTENLKQSFREELEKLVILDYIMRNTDRGLDNWMIKIDWKTEDVSIVAEPPKPNEHQQDDDDHLVPPRPVSVNSDKATSPSYPYRRHETMQAVSRTGTPLNSQEPQATIQIGAIDNSLSWPWKHPDAWRSFPFGWLFLPVSLIGQPFSQKTRDHFLPLLTSTAWWSGTQMALRRVFSQDDDFKESMFARQIAVMKGQAWNVVETLKQPDHGPLELTRRTRVCVWDDLVDVPVAIPLRGPSTEAQRRKIRGYDDRYDPDNEEMDIGAAMSVADQDLMGFQSPPSELPNPNRFELSRGRTSRDSVRPPTASSTDYGFSRDSADGLSPRRNGDQTWPSLPPRPGNKHQKHSSVSSARGAHVIWSSDDLEGDLGYAAAEGMEGNQRKVIVERIEAVKSKNPVFTWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C8V2F5</accession>
    <name>C8V2F5_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_06816</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF71517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467176.1">
        <property type="nucleotide sequence ID" value="XM_050611121.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V2F5"/>
    <dbReference type="STRING" id="227321.C8V2F5"/>
    <dbReference type="GeneID" id="2870494"/>
    <dbReference type="KEGG" id="ani:ANIA_06816"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN6816"/>
    <dbReference type="eggNOG" id="ENOG502QPZ8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032159_0_0_1"/>
    <dbReference type="InParanoid" id="C8V2F5"/>
    <dbReference type="OMA" id="RNHRIMF"/>
    <dbReference type="OrthoDB" id="550575at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="8"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF71517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="487" mass="53975" checksum="DE686CC897D41FD9" modified="2009-11-03" version="1">MQSTSSVTDPLSILPPELVLRVLEFATLSTVASLTAVSKAWHQFIDFIHQDAIYSVLSETSHPPEATFSQLFDGVPSYKSLCERQTLLARNWAAQQPVSRECILQIGNDPVWRFRADLKRRFIISTSHGGGLNVTDIDSGQLLWHLPSTLDTDNEHAVRPYAHLEYQDGMVVFDREGDAVEVWQTDVEGAPRGEFRRIAVLDHDCQTRGFQLSYWTLCVVSTQGQGFVYDMTQRPPSLTTHLQIENDAVGHLDQSHDAVIYSMGPRGYHVYNKASGEYLGALNPSQSTEKYHILPPKDDSRSATERLIHSLAGDNSLGPYSGLGPPSTEHLLPIKLEKGPLPPPDDPGHVRNGEDEWGAGMLDGDLFVGVSRAGRVFVCSNWRNAIQSQESLASCSAIIECESDGSTHDLGGWLSVRNHRLMFEVQERVYVVALDDNNRIQDIDHPTRASYSLITCSTPQLTVPVSYMALFDDAIMSIYTVSLGPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>C8V4J4</accession>
    <name>C8V4J4_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ANIA_11583</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF73477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467219.1">
        <property type="nucleotide sequence ID" value="XM_050611166.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V4J4"/>
    <dbReference type="GeneID" id="74897148"/>
    <dbReference type="KEGG" id="ani:ANIA_11583"/>
    <dbReference type="HOGENOM" id="CLU_3032318_0_0_1"/>
    <dbReference type="InParanoid" id="C8V4J4"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF73477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="55" mass="6232" checksum="A22EFE68CE23F9AC" modified="2009-11-03" version="1">MLSGVHHCPGSRFNVYRYRRGMSLPPAMARRTQSIKLFATMSGLFFHAAASRPTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>C8V4P5</accession>
    <name>C8V4P5_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DUF500 and SH3 domain protein (AFU_orthologue AFUA_6G07880)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ANIA_04168</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SH3YL1 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF74567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467349.1">
        <property type="nucleotide sequence ID" value="XM_050611310.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V4P5"/>
    <dbReference type="FunCoup" id="C8V4P5">
        <property type="interactions" value="253"/>
    </dbReference>
    <dbReference type="STRING" id="227321.C8V4P5"/>
    <dbReference type="GeneID" id="2873589"/>
    <dbReference type="KEGG" id="ani:ANIA_04168"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN4168"/>
    <dbReference type="eggNOG" id="KOG1843">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015320_2_0_1"/>
    <dbReference type="InParanoid" id="C8V4P5"/>
    <dbReference type="OMA" id="TQNDWWT"/>
    <dbReference type="OrthoDB" id="443981at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051017">
        <property type="term" value="P:actin filament bundle assembly"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd11842">
        <property type="entry name" value="SH3_Ysc84p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11525">
        <property type="entry name" value="SYLF_SH3YL1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000100">
        <property type="entry name" value="SH3 domain-containing YSC84-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051702">
        <property type="entry name" value="SH3_domain_YSC84-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033643">
        <property type="entry name" value="SYLF_SH3YL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007461">
        <property type="entry name" value="Ysc84_actin-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15629:SF2">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING YSC84-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15629">
        <property type="entry name" value="SH3YL1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04366">
        <property type="entry name" value="Ysc84"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01887">
        <property type="entry name" value="SPECTRNALPHA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="351"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="288"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="328"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="295"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBF74567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="410" mass="44251" checksum="DC9DA558DC848460" modified="2009-11-03" version="1">MPLGIHNPLPSSLSSECKKAGKILASFVDPRQAFGPDKVIPPEVLAGAKGLAILTVLKAGFLGSGRFGSGIVVARLADGSWSAPSAIATAGAGFGGQIGFELTDFVFILNDAAAVRTFSQAGTLTLGGNVSIAAGPVGRNAEAAGAASTKGVAAVFSYSKTKGLFAGVSLEGSMLVERRDANERLYNSRVSARQLLSGTIPPPPAAEPLMRVLNSRAFYGVRTNGDSMYNDIPVYDDRHDDVVWEGRRGEAYGEGIRRDRTGYHGPSDDYEYHDRPRRATTWADDIYDRPAGGLSRSSTARFSSRNDTFDTYNRQRSNTYDDDYVYSDRKPSRPTAPKPVFGQRTGQAAPLREDQAIALYTFDADQDGDLGFKKGEIITIIKRTEKKEDWWTGRIGDRVGIFPANYVDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>C8V503</accession>
    <name>C8V503_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ANIA_11429</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF74643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V503"/>
    <dbReference type="HOGENOM" id="CLU_3421362_0_0_1"/>
    <dbReference type="InParanoid" id="C8V503"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF74643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="24" mass="3024" checksum="652C5BEE30CD0185" modified="2009-11-03" version="1">MYLLPIQFYISKSTRLWDFKYGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>C8V5W7</accession>
    <name>C8V5W7_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_10494</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF74962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467389.1">
        <property type="nucleotide sequence ID" value="XM_050611353.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V5W7"/>
    <dbReference type="GeneID" id="74896437"/>
    <dbReference type="KEGG" id="ani:ANIA_10494"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN10494"/>
    <dbReference type="eggNOG" id="KOG1208">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_44_6_1"/>
    <dbReference type="InParanoid" id="C8V5W7"/>
    <dbReference type="OMA" id="PFMKDPI"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05327">
        <property type="entry name" value="retinol-DH_like_SDR_c_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF31">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF74962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="327" mass="35832" checksum="8F5AD8AEFDF01992" modified="2009-11-03" version="1">MFRSSNTFNPNTDIPDLSGKVYVVTGGSAGIGFGICAHLLQHNPAALYLLGKKEEHIQEATEGLKKYGDTSKVHSVQIELEDLKQTDQVAKELASKLDRLDGLICNAGLGSGVFNLTNDGIDSHMQVNHISQFHLSRILLPLLQKTSNSRLVLQSSDLHRAISDVKFESLEELNTDIGPTKLYNRTKLAMVLYIRALAERKGKGQLGFDPKTDTGPWMNATHPGAVSTDQQKQAEDAYGVLGKVGVAIVRPFLKDPVDQGCRPALFAATGEDIVKDAIQGQYIVPDRSPTSPSSEAQNHQLQENLWKLTEKILVDKLGSVPYETQYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C8V7M6</accession>
    <name>C8V7M6_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial import inner membrane translocase subunit TIM54</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">ANIA_10453</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TIM54 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF75615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467489.1">
        <property type="nucleotide sequence ID" value="XM_050611460.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V7M6"/>
    <dbReference type="FunCoup" id="C8V7M6">
        <property type="interactions" value="19"/>
    </dbReference>
    <dbReference type="STRING" id="227321.C8V7M6"/>
    <dbReference type="GeneID" id="74896410"/>
    <dbReference type="KEGG" id="ani:ANIA_10453"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN10453"/>
    <dbReference type="eggNOG" id="ENOG502QSFX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039097_1_0_1"/>
    <dbReference type="InParanoid" id="C8V7M6"/>
    <dbReference type="OMA" id="RNWMIFF"/>
    <dbReference type="OrthoDB" id="5598305at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
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    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050187">
        <property type="entry name" value="Lipid_Phosphate_FormReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021056">
        <property type="entry name" value="Mt_import_IM_translocase_Tim54"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358:SF101">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358">
        <property type="entry name" value="SPHINGOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11711">
        <property type="entry name" value="Tim54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="210"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="341"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="250"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
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            <begin position="345"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
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            <begin position="372"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006355"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020796"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CBF75615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="476" mass="52979" checksum="3B65DA6B0C80C293" modified="2009-11-03" version="1">MADSTASASSEAAKSAPKPQNPALKMMGLPNFRFKLPSRNWMIFLTITGSFTAALIYDRREKRRAQQKWCNLVAHISKESLPVEETRRKLTVFLAAPPGDGIRSAREHFKEYVKPILVAAALDYNVIEGRREGDIRAKFAEEIRKQRRKSGEVSAGIIGDEEKSTEDVIAEARKAIGVREEPGPRGDLVIGRHTWKEYVRGLHEGWLGPIDPPVSAESQPALEEPQVPAAEVPANTEEQATPAPEQGQAAEKKEEGEEEKKPSKPTGPASAYIAPSDYSGRTLPPSIPQTLDGSAAIPFPHLLGFLNTPIRIYRFLNRRYVADSVGRDVAALVLASHARPYAEGPASSSSDSDSPVDPSLSSSITYEQQSQLEHEEHDWHKSVHKTDDSNPDKEREWLNDVVMDPRIAARMQRYVLSGEEEARAQRIAQGSEYIRGEERPPVVPFWQRVWIKYGYGEDPEVAKRKPIIGNLDEENA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2025-10-08" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>C8V997</accession>
    <name>C8V997_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">U3 small nucleolar ribonucleoprotein protein MPP10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ANIA_04298</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in nucleolar processing of pre-18S ribosomal RNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
            <location evidence="1 7">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the MPP10 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF77817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_661902.2">
        <property type="nucleotide sequence ID" value="XM_656810.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V997"/>
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        <property type="interactions" value="921"/>
    </dbReference>
    <dbReference type="STRING" id="227321.C8V997"/>
    <dbReference type="GeneID" id="2872090"/>
    <dbReference type="KEGG" id="ani:ANIA_04298"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN4298"/>
    <dbReference type="eggNOG" id="KOG2600">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011271_1_0_1"/>
    <dbReference type="InParanoid" id="C8V997"/>
    <dbReference type="OMA" id="HFAEDFG"/>
    <dbReference type="OrthoDB" id="445326at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034457">
        <property type="term" value="C:Mpp10 complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005732">
        <property type="term" value="C:sno(s)RNA-containing ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012173">
        <property type="entry name" value="Mpp10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17039">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN MPP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17039:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN MPP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04006">
        <property type="entry name" value="Mpp10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017300">
        <property type="entry name" value="snoRNP_Mpp10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 7" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3 7" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="121"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="225"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="362"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="624"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="146"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="189"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="225"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="269"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="362"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR017300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBF77817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="688" mass="77011" checksum="4D573727249165DB" modified="2009-11-03" version="1">MSATQDRHGPGTSNLAPLPLNSALLSPWDFLRPTKKLRTEVLDTAKIFLDSLASSVCDSQNTRQRNSKKRKRPDDDHHAASILRLRQLYVDGFTSDQVWEQALRIFNSADQEIQRDYTVCANNRQPGSSEESPSEDGINSLRDASDEPEDILEDFSDDNEQGGERDGEAEDSSQSDLEESEDGVHQTEEDPYDEEDENLGTYIEDRFGLNDGFFSIDDFNKQTELFEQRDARGDVEDESDEEDINWHANPLDARGPSTLSQKQEKAVGVDDDLSGSDDDASEEEGPTFDNMAELDSEDEDVTAAAGAGFSNTSDIMYADFFAPPPRKASAKKSRPLPKTQPRITDNDIDRAMADVRRDLFDDDEASVQDSDNEPGVGRTHQSTHEKQRARIADEIRRLEAANVAKKEWMVSGEARAAERPVNSLIEEDLDFERVGKPVPVVTTELSESIEELIKRRIIAKEFDEVIRRRPGLLDRQLTQKARVEIEDSKPQQGLAELYETDHIRTTDSNYVDPKHQKLLKEHTEITNLWKEISSQLDTLSNWHYKPKAPQASINVVTDVATITMEDAQPTAGGAIRASAALAPQEIYAPSETTRATGEIVMRDGVPVTKEEMTREDKARFRRRQKKMAQASANSNQPRSRKALEKQQIVSDLKKAGVKLIGKEGDMMNINGSKIVGTVDRNGAHAIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>C8VBA8</accession>
    <name>C8VBA8_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Fungal specific transcription factor, putative (AFU_orthologue AFUA_2G06130)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ANIA_07434</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF79375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467953.1">
        <property type="nucleotide sequence ID" value="XM_050611987.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VBA8"/>
    <dbReference type="STRING" id="227321.C8VBA8"/>
    <dbReference type="GeneID" id="2869360"/>
    <dbReference type="KEGG" id="ani:ANIA_07434"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN7434"/>
    <dbReference type="eggNOG" id="ENOG502S1X9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015361_0_0_1"/>
    <dbReference type="InParanoid" id="C8VBA8"/>
    <dbReference type="OMA" id="DHTVGWE"/>
    <dbReference type="OrthoDB" id="10031947at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009062">
        <property type="term" value="P:fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052073">
        <property type="entry name" value="Amide_Lactam_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47171">
        <property type="entry name" value="FARA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47171:SF6">
        <property type="entry name" value="SPECIFIC TRANSCRIPTION FACTOR, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G06130)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="6">
        <location>
            <begin position="275"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBF79375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="636" mass="69717" checksum="DD6DD7DDC7F34403" modified="2009-11-03" version="1">MEITWLADSPQSRRRARALQACPTCRRRKKRCRHIVADTSNADIPETRRARPQIRTSGDSSAIAGAEKPRHFLALSTGISRVERFVGDLNPEAAIREKVDAPNGAFHRDRVGLWISNHGENPNRSSHATSVGATISEAQPVASLLHRRYTSALKACDRLPRSTSEPLASIYFSRVNHILPIVDHELFAGEYLNGAASVFLERAICLVAAKDKTASPHLRLTAGGALNTARKFCSEVYGGLVCAMEAGLEQDRVTRIRILALMSLHFEGYEGAEAASMHLCQAIHQAQTLGLHLERPKLAPDDSLTTLFWCLWSLDKMHASIGGRPVLLADRDIGIRRHDSAARQSKSAFDAWFALSELLSKVISFYRPTADDTTGWETEYPSFEEIIGNSIQGQIDFATLGILELYYHVISILSCRCRSSQHLSGSRPSRTRQGLAAVRINSLVASECAQGLPPLPVIPYAVSLSMSVSYQELRSSTLITQFNRAKASLEACCNMLEELVSWCSAEAMARLGRKALRQIDGISFATDMLSVSDNGGGKNPNRTTASAADLGISKASMPSSSSFDTHQPSNDNLLAVTDPEQHVIPLVDEQQAYLQGPTSGDGFADIDMLFDDFLDLSLPTNFWDPIFVSSEYSNDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>C8VBX5</accession>
    <name>C8VBX5_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Zn(II)2Cys6 transcription factor (Eurofung)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ANIA_10976</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF79773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468002.1">
        <property type="nucleotide sequence ID" value="XM_050612042.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VBX5"/>
    <dbReference type="STRING" id="227321.C8VBX5"/>
    <dbReference type="GeneID" id="74896711"/>
    <dbReference type="KEGG" id="ani:ANIA_10976"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN10976"/>
    <dbReference type="eggNOG" id="ENOG502SHT0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012331_2_0_1"/>
    <dbReference type="InParanoid" id="C8VBX5"/>
    <dbReference type="OMA" id="MMILVLR"/>
    <dbReference type="OrthoDB" id="25921at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052202">
        <property type="entry name" value="Yeast_MetPath_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782:SF1">
        <property type="entry name" value="PYRIMIDINE PATHWAY REGULATORY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="12"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBF79773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="715" mass="79699" checksum="6C7851E2EFC7E30D" modified="2009-11-03" version="1">MDSPKRARNRAACKRCQRRKIRCDGNIPSCSSCLKAGVPCINDGKQEVHRSHIAGMENRIKWLESIVQNRCPDIDLSCGPGSARESLDDGMQTETVNEPTEPYTRDYHQASHDPLQASRNPQIEVSPRVVITGDQEASRACSQPAVNEESHQAHEIGLVSLSPGGERRYIGPSSGYFFAKRILDNAGCRGGPRISTTAALDSAHLSLELLNTPAAMPVQKQSTIELTTKYFQTIHLLYPFLHEQMHMDAINRVYACQDKNPLETFQVYMVLAIASLNLSRQCKVRLPVEGYYASAMKHVDYVCNHGSVTSLQCLLLLMVYALYNPSCNIDIWNLNYQCLASVIDLGLQRDVRASSTLQISMFDQEMRTRIFWVVYTFDRTVCTMMGRPIGIRDEACDIRFPLAISDHDLIKIGKDTQTYGESTSHMSYSIHLFKLAQLNSEIKYIMHSINRSVPAYALPVIRDILSWQQEMVQSLDSWFAAIPPQPPGVSAEIVLLCKAKYHETMILLLRSSPGIPNPSDAVLDECFNHALGLLRKFSELYTIGSLLYSRLAVHSIFVGALVMLNCIWKLPAAAARVPVDELISNFNTTQNILSGIGEHWSEAMRARDCVKELSTATIQRLLRTQPGQPQSSTSQPLYYPIHRSTGQAAIEGHADVHGAAIHVTHSELNTGFDPSASNSEFSNLFDDFLQGDFMGYSGMSDIDGLMWEIFNSAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>C8VCA2</accession>
    <name>C8VCA2_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ubiquinone biosynthesis protein, putative (AFU_orthologue AFUA_4G04590)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ANIA_06996</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. ADCK protein kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF79292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467934.1">
        <property type="nucleotide sequence ID" value="XM_050611967.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VCA2"/>
    <dbReference type="FunCoup" id="C8VCA2">
        <property type="interactions" value="91"/>
    </dbReference>
    <dbReference type="STRING" id="227321.C8VCA2"/>
    <dbReference type="GeneID" id="2869970"/>
    <dbReference type="KEGG" id="ani:ANIA_06996"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN6996"/>
    <dbReference type="eggNOG" id="KOG1236">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006533_6_0_1"/>
    <dbReference type="InParanoid" id="C8VCA2"/>
    <dbReference type="OMA" id="SMVRTHH"/>
    <dbReference type="OrthoDB" id="1290869at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd13971">
        <property type="entry name" value="ADCK2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044095">
        <property type="entry name" value="ADCK2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052402">
        <property type="entry name" value="ADCK_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45890:SF1">
        <property type="entry name" value="AARF DOMAIN CONTAINING KINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45890">
        <property type="entry name" value="AARF DOMAIN CONTAINING KINASE 2 (PREDICTED)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="ABC1 atypical kinase-like" evidence="3">
        <location>
            <begin position="202"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="ABC1 atypical kinase-like" evidence="3">
        <location>
            <begin position="293"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBF79292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="685" mass="77503" checksum="121508D726EC2EDF" modified="2009-11-03" version="1">MRISLQLRCIRATCGRTPQLLARLPLPPSRRFTQLSCPQRPSQGRQKGVPRIGAVIFAALAPGAFVKIAETEDDGKTGERLMLEASRQEFREDVLEKTEQRIGLGGPVVAYWTYYVYDTIATGFRFVHLVIIFLPVILTAPTIWLGRRIKNNDGARTGTLWWYSFLVRAMERAGPAFIKLGQWAASRTDIFPPEMCEIMSSLHSNAPGHSLHETKRIIEKAFSGMPFEDIFEEFNEEPLGVGAIAQVYKAKLKPNLANLADNQLTCEPQNLRGKLRKNVDALVKSTPRRVPSSYVAVKVLHPRVERLIRRDLRIMSFFASLLNAVPTMHWLSFPDEVAQFGEMMKLQLDLRIEATNLKIFREKFRSRTTAWFPYPYLDYSTREVLIEEFAQGIPLSTFLEKGGGVYQHEIANEGLDAFLHMLLIDNFVHADLHPGNIMVRFYQPSELDLSLRKKGRADEAPTLKEVDVADAILARLLPHADDSQKWERALEELNAEGYRPQLLFIDTGLVTQLNDTNRANFLALFRAVAEFDGHRAGELMVERCRQPEEVIDPDIFALRMQNLVLGVKSRTFALGNIKIGDILSEVLSMVRRHHVRLEGDFVNVVISILLLEGIGRSMDPDLDLFKSALPILRKLGSNATFLKTIRSGDTSMLRVWVGLEARGLLRASIESVENCVKYDLLSPNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>C8VD17</accession>
    <name>C8VD17_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glutamate-rich WD repeat-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ANIA_07205</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="XP_050467884.1">
        <property type="nucleotide sequence ID" value="XM_050611913.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VD17"/>
    <dbReference type="FunCoup" id="C8VD17">
        <property type="interactions" value="851"/>
    </dbReference>
    <dbReference type="STRING" id="227321.C8VD17"/>
    <dbReference type="GeneID" id="2869951"/>
    <dbReference type="KEGG" id="ani:ANIA_07205"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN7205"/>
    <dbReference type="eggNOG" id="KOG0302">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025272_1_0_1"/>
    <dbReference type="InParanoid" id="C8VD17"/>
    <dbReference type="OMA" id="RHWKPNA"/>
    <dbReference type="OrthoDB" id="2161379at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051972">
        <property type="entry name" value="Glutamate-rich_WD_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022052">
        <property type="entry name" value="Histone-bd_RBBP4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
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        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45903">
        <property type="entry name" value="GLUTAMATE-RICH WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45903:SF1">
        <property type="entry name" value="GLUTAMATE-RICH WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12265">
        <property type="entry name" value="CAF1C_H4-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Histone-binding protein RBBP4-like N-terminal" evidence="8">
        <location>
            <begin position="87"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="299"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="399"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="154"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="164"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBF78870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="492" mass="53770" checksum="4A2AB186DE4AE23C" modified="2009-11-03" version="1">MSKRSADASEDAAALKAGERPLADAPPDDMGEFEDEFEDEFESEDEILEAGVDGRPDAEREEEEKADAMEVDQQTFIPGRTKLAPGEVLSPDPSTYDMLHTLSTPWPCLSFDIVRDTLGDNRKTYPATVYAVTGTQAEGRRAKENELMVLKLSGLGKMERENETDSESDSDDDEGGEAILEHKSIPLGSTANRIRAHQTPQSDITKPPQTITATMLENSQVVIHDVTPHLTSFDVPGTMLPPSASKPLSTLRMHKSEGYALDWSPLHPLGKLLTGDNDGLIYVTTRTEGGGWVTDTRAFRGHASSVEELQWSPNEKNVFASASSDGTVKVWDVRSKSRSPAVNVKISNTDVNVMTWSKQTSHLLATGADDGQWAVWDLRHWKPNPSSSAPITASPVASFNFHKEPITSIEWHPTDDSVIAVGSADNTVTLWDLAVELDEEESREAGLADVPPQLLFVHYMESVKEVHWQAQMPGTLMATGSGGFGVFKTISV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>C8VDJ7</accession>
    <name>C8VDJ7_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Bacteriophage T5 Orf172 DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_07732</name>
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    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF79994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_681001.2">
        <property type="nucleotide sequence ID" value="XM_675909.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VDJ7"/>
    <dbReference type="STRING" id="227321.C8VDJ7"/>
    <dbReference type="GeneID" id="2869705"/>
    <dbReference type="KEGG" id="ani:ANIA_07732"/>
    <dbReference type="eggNOG" id="ENOG502QWMU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024511_0_0_1"/>
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        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
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            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
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                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
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            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
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        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
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        <property type="nucleotide sequence ID" value="XM_050612111.1"/>
    </dbReference>
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    <dbReference type="InParanoid" id="C8VDY8"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="EMBL" id="CBF80259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
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    <accession>C8VHC6</accession>
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            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
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                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
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                <person name="Birren B.W."/>
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            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
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                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
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            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
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        <property type="nucleotide sequence ID" value="XM_050612449.1"/>
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    <dbReference type="AlphaFoldDB" id="C8VHC6"/>
    <dbReference type="GeneID" id="74896990"/>
    <dbReference type="KEGG" id="ani:ANIA_11396"/>
    <dbReference type="HOGENOM" id="CLU_3320032_0_0_1"/>
    <dbReference type="InParanoid" id="C8VHC6"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF82700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="39" mass="4646" checksum="87533073FE6B45C0" modified="2009-11-03" version="1">MVRTLRANWHRTYLFILGFVRRRNDTLNDLSAALRPSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>C8VHP5</accession>
    <name>C8VHP5_EMENI</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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    <gene>
        <name evidence="1" type="ORF">ANIA_11392</name>
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    <organism evidence="1 2">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
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            <taxon>Eurotiales</taxon>
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        </lineage>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF82827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468387.1">
        <property type="nucleotide sequence ID" value="XM_050612467.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VHP5"/>
    <dbReference type="GeneID" id="74896986"/>
    <dbReference type="KEGG" id="ani:ANIA_11392"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN11392"/>
    <dbReference type="HOGENOM" id="CLU_3392298_0_0_1"/>
    <dbReference type="InParanoid" id="C8VHP5"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF82827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="32" mass="3523" checksum="C0254EF8DE24C272" modified="2009-11-03" version="1">MEAPQSVVSLQCGWNVSFLRAKPKSVDPIHPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>C8VJF3</accession>
    <name>C8VJF3_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">D-arabinono-1,4-lactone oxidase</fullName>
            <ecNumber evidence="2">1.1.3.37</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">L-galactono-gamma-lactone oxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ANIA_02835</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; D-erythroascorbate biosynthesis; dehydro-D-arabinono-1,4-lactone from D-arabinose: step 2/2.</text>
    </comment>
    <dbReference type="EC" id="1.1.3.37" evidence="2"/>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF83909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468523.1">
        <property type="nucleotide sequence ID" value="XM_050612620.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VJF3"/>
    <dbReference type="GeneID" id="2873978"/>
    <dbReference type="KEGG" id="ani:ANIA_02835"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN2835"/>
    <dbReference type="eggNOG" id="KOG4730">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_530170_0_0_1"/>
    <dbReference type="InParanoid" id="C8VJF3"/>
    <dbReference type="OMA" id="YGMISPY"/>
    <dbReference type="OrthoDB" id="371463at2759"/>
    <dbReference type="UniPathway" id="UPA00771">
        <property type="reaction ID" value="UER00766"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003885">
        <property type="term" value="F:D-arabinono-1,4-lactone oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007173">
        <property type="entry name" value="ALO_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010031">
        <property type="entry name" value="FAD_lactone_oxidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43762:SF1">
        <property type="entry name" value="D-ARABINONO-1,4-LACTONE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43762">
        <property type="entry name" value="L-GULONOLACTONE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04030">
        <property type="entry name" value="ALO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00033418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBF83909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="436" mass="49535" checksum="91563ED68311BB66" modified="2009-11-03" version="1">MWYDTMCSDDPNTVIIQTENVNNIHDLDLEAGTVMIEAGVTFLQLAEYLHERGASAGYTLVNWNITLAGCVAMGAHRSSIREDSMVAAGVLALDIIDGEGNLRHLERDDSDEWLAASTSLGLLGVIARMKFKIYPDFKVYADQKTLDEAEVFDGDIYGMIAPYATANFWWWPYKRKFHWRYYDVVENSINEQQGFQNTFSVTGVEAAAIKVLWNSGRWLATSNMLAEEILFGQWEAPNFREKTTNKAIDTWPVYGWNYDVLIGGLYPDQKPVWEYGLSGYTLELAFPVTQANAVLKRARELFDAELKKGLVMTSTYRSGINIKFGRPYYDLLGQVTYNTSDGADWSKGAIMFDFPSFKPTVGDGSRFNEPFYGTLEKALIEEFPCRPHWTKNTREVFQLAKKNLDPDHIARFKAIREKFDPNGVYRSVVGEIIGVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>C8VJK5</accession>
    <name>C8VJK5_EMENI</name>
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        <recommendedName>
            <fullName evidence="5">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_02792</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF84002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468540.1">
        <property type="nucleotide sequence ID" value="XM_050612640.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VJK5"/>
    <dbReference type="GeneID" id="2873940"/>
    <dbReference type="KEGG" id="ani:ANIA_02792"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN2792"/>
    <dbReference type="eggNOG" id="ENOG502RY6P">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082451_0_0_1"/>
    <dbReference type="InParanoid" id="C8VJK5"/>
    <dbReference type="OMA" id="DYLDQQD"/>
    <dbReference type="OrthoDB" id="3596006at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="35"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="79"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="178"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF84002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="239" mass="26842" checksum="BC82767AD8B0963F" modified="2009-11-03" version="1">MTVIWGLDLHEICFSKFRSANMLNRAYHLRRTKMVVYQLAMILCVCSESVGTAAFSDYLDQQSYIQGQHPGVKIHNNSFIGAFSYNVFVGVAVAFIFGAAFFFDLFWPERHECKHVRISWKISAVVVTVMMLSSALTITCIGALHDAVVTGTDRDTAQTYRLEFSKKPSYTYRDNPKVIAAVVLAWPGWVFCVISTIVLFMSQKHDDKYGPMSKYGRSQEDGSIVVDKEGHNSPEPTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>C8VL50</accession>
    <name>C8VL50_EMENI</name>
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        <recommendedName>
            <fullName evidence="3">Cnl2/NKP2 family protein-domain-containing protein</fullName>
        </recommendedName>
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        <name evidence="1" type="ORF">ANIA_01977</name>
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        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
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        <lineage>
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            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF85933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468778.1">
        <property type="nucleotide sequence ID" value="XM_050612926.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VL50"/>
    <dbReference type="STRING" id="227321.C8VL50"/>
    <dbReference type="GeneID" id="2875281"/>
    <dbReference type="KEGG" id="ani:ANIA_01977"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN1977"/>
    <dbReference type="eggNOG" id="ENOG502S7X4">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_077446_2_0_1"/>
    <dbReference type="InParanoid" id="C8VL50"/>
    <dbReference type="OMA" id="REQDMDR"/>
    <dbReference type="OrthoDB" id="2311687at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031511">
        <property type="term" value="C:Mis6-Sim4 complex"/>
        <property type="evidence" value="ECO:0000318"/>
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    <dbReference type="InterPro" id="IPR018565">
        <property type="entry name" value="Nkp2/Cnl2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28064">
        <property type="entry name" value="INNER KINETOCHORE SUBUNIT NKP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28064:SF1">
        <property type="entry name" value="INNER KINETOCHORE SUBUNIT NKP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09447">
        <property type="entry name" value="Cnl2_NKP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF85933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>C8VLB2</accession>
    <name>C8VLB2_EMENI</name>
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            <fullName evidence="12">1,3-beta-glucanosyltransferase</fullName>
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    <gene>
        <name evidence="15" type="ORF">ANIA_11152</name>
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        <lineage>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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        </lineage>
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    <reference evidence="16" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="16">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall. Involved in cell wall morphogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Cell membrane</location>
            <topology evidence="1 12">Lipid-anchor</topology>
            <topology evidence="1 12">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the glycosyl hydrolase 72 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="12"/>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF84598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468595.1">
        <property type="nucleotide sequence ID" value="XM_050612707.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VLB2"/>
    <dbReference type="FunCoup" id="C8VLB2">
        <property type="interactions" value="156"/>
    </dbReference>
    <dbReference type="STRING" id="227321.C8VLB2"/>
    <dbReference type="GeneID" id="2868166"/>
    <dbReference type="KEGG" id="ani:ANIA_11152"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN11152"/>
    <dbReference type="eggNOG" id="ENOG502QPST">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021855_2_1_1"/>
    <dbReference type="InParanoid" id="C8VLB2"/>
    <dbReference type="OMA" id="QDHTECM"/>
    <dbReference type="OrthoDB" id="421038at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031982">
        <property type="term" value="C:vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042124">
        <property type="term" value="F:1,3-beta-glucanosyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071970">
        <property type="term" value="P:fungal-type cell wall (1-&gt;3)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1040:FF:000005">
        <property type="entry name" value="1,3-beta-glucanosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000038">
        <property type="entry name" value="1,3-beta-glucanosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004886">
        <property type="entry name" value="Glucanosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012946">
        <property type="entry name" value="X8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468:SF9">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03198">
        <property type="entry name" value="Glyco_hydro_72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07983">
        <property type="entry name" value="X8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00768">
        <property type="entry name" value="X8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 12" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="10 12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0732">Signal</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005125835" description="1,3-beta-glucanosyltransferase" evidence="12">
        <location>
            <begin position="20"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="X8" evidence="14">
        <location>
            <begin position="381"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="478"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CBF84598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="524" mass="55885" checksum="2CB403B233A24919" modified="2009-11-03" version="1">MKFALAAAAASALFGQVMADVDPIIIKGSKFFYSSNNTQFYIRGVAYQQDYTTNSTSSSDSSYKDPLADETACKRDIPILQDLNTNTIRVYAIDPTKNHTTCMNMLADAGIYVIADLSDPSESIDRNDPRWETALYTRYTNVIDAMAGFSNTLGFFAGNEVSNTVQTTDASAFVKAAVRDMKAYIKAQNYRSGLGVGYATNDDKSIRVQLADYFNCESEEDSIDFWGYNIYSWCGDSTYTESGYKDRTEEFANYSVPVFFAEYGCNEVTPRKFTEIEALFGDKMNGVWSGGIVYMYFQEANDYGLVSVVDSTSVSTMADYKYYSSQINAVSPSGTNKASYTPTNTALQSCPAVTSGSWLAKATPLPPTPNTDLCSCMDKTNACVVDSSVDSDDYADLFSIVCGLTECAGVSANGTTGSYGAYGMCQSKQQLNWALNKYYSEQGSVASACDFDGSATTTATTAATGSCSSMMSQAGTDGTGTVTATATGSGSSATETESSGANALNVGVSAGAGGFVVAVLGYLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>C8VLC5</accession>
    <name>C8VLC5_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ubiquinone biosynthesis O-methyltransferase, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">3-demethylubiquinol 3-O-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.64</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">3-demethylubiquinone 3-O-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.-</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Polyprenyldihydroxybenzoate methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.114</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">COQ3</name>
        <name evidence="6" type="ORF">ANIA_01999</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">O-methyltransferase required for two non-consecutive steps during ubiquinone biosynthesis. Catalyzes the 2 O-methylation of 3,4-dihydroxy-5-(all-trans-polyprenyl)benzoic acid into 4-hydroxy-3-methoxy-5-(all-trans-polyprenyl)benzoic acid. Also catalyzes the last step of ubiquinone biosynthesis by mediating methylation of 3-demethylubiquinone into ubiquinone. Also able to mediate the methylation of 3-demethylubiquinol into ubiquinol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 3,4-dihydroxy-5-(all-trans-polyprenyl)benzoate + S-adenosyl-L-methionine = a 4-hydroxy-3-methoxy-5-(all-trans-polyprenyl)benzoate + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:44452"/>
            <dbReference type="Rhea" id="RHEA-COMP:10930"/>
            <dbReference type="Rhea" id="RHEA-COMP:10931"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64694"/>
            <dbReference type="ChEBI" id="CHEBI:84443"/>
            <dbReference type="EC" id="2.1.1.114"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 3-demethylubiquinol + S-adenosyl-L-methionine = a ubiquinol + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:44380"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="Rhea" id="RHEA-COMP:10914"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:84422"/>
            <dbReference type="EC" id="2.1.1.64"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 3-demethylubiquinone + S-adenosyl-L-methionine = a ubiquinone + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:81215"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:19654"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:231825"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Mitochondrion inner membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.64" evidence="5"/>
    <dbReference type="EC" id="2.1.1.-" evidence="5"/>
    <dbReference type="EC" id="2.1.1.114" evidence="5"/>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF85983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VLC5"/>
    <dbReference type="FunCoup" id="C8VLC5">
        <property type="interactions" value="317"/>
    </dbReference>
    <dbReference type="STRING" id="227321.C8VLC5"/>
    <dbReference type="GeneID" id="2875119"/>
    <dbReference type="KEGG" id="ani:ANIA_01999"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN1999"/>
    <dbReference type="eggNOG" id="KOG1270">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042432_3_1_1"/>
    <dbReference type="InParanoid" id="C8VLC5"/>
    <dbReference type="OMA" id="LASRWWD"/>
    <dbReference type="OrthoDB" id="3265906at2759"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031314">
        <property type="term" value="C:extrinsic component of mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061542">
        <property type="term" value="F:3-demethylubiquinol 3-O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120537">
        <property type="term" value="F:3-demethylubiquinone 3-O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010420">
        <property type="term" value="F:polyprenyldihydroxybenzoate methyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00472">
        <property type="entry name" value="UbiG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010233">
        <property type="entry name" value="UbiG_MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43464">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43464:SF19">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS O-METHYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 5" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBF85983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="347" mass="37818" checksum="45A4FA54EF3816DF" modified="2009-11-03" version="1">MAMTPVRPAFRKISLLRCPSVRRSHSTSTSSVSASEVSHFSSLASSWWDPMGPSRVLHLMNPIRHEFIASCLAESSPDSLTKQPGTPPNTLHYLDVGCGGGIFAESLARTIPIPGSTESKSGTVTRAASITAIDPTTTLIQIARDHARKDPKVLAHLNEGRFQYVNCTLEDVIASSPNANQSSNSTDASRAGAGVRRKDGFDVITLFEVIEHIDTNASITPLTFLTNCLRLLKPGGWLIGSTIARTFPSWLVNQVIAEAPWPVGVVPKGTHEWKKFVNPDELESWASEGLMRSVDLERNSVARSGSEALDGMRWKCAGVVYFPGLGWKFVPGSESWGNYFWAIRRGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>C8VLV2</accession>
    <name>C8VLV2_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_08871</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF84767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468620.1">
        <property type="nucleotide sequence ID" value="XM_050612738.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VLV2"/>
    <dbReference type="STRING" id="227321.C8VLV2"/>
    <dbReference type="GeneID" id="2868218"/>
    <dbReference type="KEGG" id="ani:ANIA_08871"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN8871"/>
    <dbReference type="eggNOG" id="ENOG502SHAB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011743_1_1_1"/>
    <dbReference type="InParanoid" id="C8VLV2"/>
    <dbReference type="OMA" id="MCYLSEQ"/>
    <dbReference type="OrthoDB" id="4716584at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="450"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="456"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="479"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF84767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="605" mass="67979" checksum="68C52777AC79A233" modified="2009-11-03" version="1">MSQAASTTSRKPRRFLPEPIETSSRSSKNRQDNELTTQCLHQMQTSFRTSEIRSTSCKNEDSGRSSHPPPQQTCLSPCLTTDHDAHRFTATMHKTPFTQVIGGNQQGNAKRYTPQLMETVRHSFRPGKKPAKLFSSAGLGTQSSRDAIEAANRMEADHGAVQESRFSYSSLLRRQETRRHSFRVPDLPAIPSSGSDESNESDSPQVSSETIATARGTFSDDTARPRNGREMSFIEYILPFPRHPSENQLKEQALAAFPNEQVYQQVDHFAIDRDEEEPVNEDIIKIRDPELEFRTRRRASSADLPSELEYLRKHKEEAGMNRRHYFTTRGACFSTCAVYQTSRKSGKPANHDDGWDPNSPFARLRQAASPPMLGGDLIFPQSLTPKTTICEHPNSVGSQGHRDHSLGSGLWSACPCSSAQYDIGGLWNGTCKSDRYSTHGVENLSREAITPKKDVINNNSGNLDASSKASNLRHRKRQNAVQSPTNESADSERIDQEFNDDFVTQIYDYLSLGYPSIARYFDHELSRVSGLPIAALRADDLNMDAKGYVGVNDITNKGVANRVCMRWTALKLYIHEWARQHPRMLEAGHYHETWGVSERKGSWAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>C8VMC5</accession>
    <name>C8VMC5_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome c oxidase assembly factor 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ANIA_11304</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Required for assembly of cytochrome c oxidase (complex IV).</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 9">Component of 250-400 kDa complexes called cytochrome oxidase assembly intermediates or COA complexes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the COA3 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF84895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468642.1">
        <property type="nucleotide sequence ID" value="XM_050612762.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VMC5"/>
    <dbReference type="GeneID" id="74896908"/>
    <dbReference type="KEGG" id="ani:ANIA_11304"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN11304"/>
    <dbReference type="eggNOG" id="ENOG502SEY5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_153999_2_1_1"/>
    <dbReference type="InParanoid" id="C8VMC5"/>
    <dbReference type="OMA" id="WYTLNAV"/>
    <dbReference type="OrthoDB" id="10018333at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041752">
        <property type="entry name" value="Coa3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018628">
        <property type="entry name" value="Coa3_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15642:SF3">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 3 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15642">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09813">
        <property type="entry name" value="Coa3_cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c oxidase assembly factor 3 mitochondrial coiled-coil" evidence="10">
        <location>
            <begin position="21"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF09813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CBF84895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="77" mass="8352" checksum="4B1FF351F940A6B0" modified="2009-11-03" version="1">MPAGIFNSTYYGKDYRAGAALLRARRPYLFKNAATGLGLCMFTIGVYAYTIRAVGQDEFSDVKVPDAPAAAPQQSKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>C8VMQ2</accession>
    <name>C8VMQ2_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Zn(II)2Cys6 transcription factor (Eurofung)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ANIA_01518</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF85031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468669.1">
        <property type="nucleotide sequence ID" value="XM_050612791.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VMQ2"/>
    <dbReference type="GeneID" id="2875361"/>
    <dbReference type="KEGG" id="ani:ANIA_01518"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN1518"/>
    <dbReference type="eggNOG" id="ENOG502QSY9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007426_0_2_1"/>
    <dbReference type="InParanoid" id="C8VMQ2"/>
    <dbReference type="OMA" id="EPPEWRG"/>
    <dbReference type="OrthoDB" id="762982at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051430">
        <property type="entry name" value="Fungal_TF_Env_Response"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31944">
        <property type="entry name" value="HEME-RESPONSIVE ZINC FINGER TRANSCRIPTION FACTOR HAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31944:SF131">
        <property type="entry name" value="HEME-RESPONSIVE ZINC FINGER TRANSCRIPTION FACTOR HAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="33"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="104"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="780"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBF85031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="825" mass="92763" checksum="D10E99FA53C61895" modified="2009-11-03" version="1">MSPTPPSTTSSSNGPSPEGQYRIVRKRNRVPLSCGPCRHRKLKCNRAHPCENCVKRGDAHSCTYAQTNSRKKNSANQAASTSPDDMQNRIDRLEGLVLSLMTNGSQSEGPAAAMAAISGTSSSTGSAQHVHDLEIEDEGPNQEESETEQVTKSFGIMKMDNNKSYYISDAHWASVLSEISEVKNYFNTHKKQYEEQAEKLKATKLPTDVPGSTLLFGAMKATSRAEIMSSFPSKYTTDMLIARYFNCYDPATHFLHGPTFQAQYNKHWEDPSQTCIVWIGMLFAMMRLAMLSYYREGDEPPEFRGKSLDMAGTFRNLVAMCLTLADYTKPYPYLIECLAFHLHGDFCQTKEADVSVWVLNGVIVRLAMRMGYHRDSKAFPNITPFQGEMRRRVWSFVRQADLLFSCQVGLPSMIRMADSDTELPRNLYDDDFDENCKELPPSRPPNEPTPLSYLITKSRLANVLGQAIEQTSSLQNTPYDKVIEMDSELRRARDMIPDHLLVRPFEESSLDPLGLIMSRFSVMSVYHRAQCLLHRKYILRARENPRFIHSRRTCIDSALELLRYQSMLHVETRPTGRLRSRQNRVTTLSSSDFLQAATIICLDLYHGYNLPSASRASSDTYAWGRDRREEMMAAVQRSKEIWDELRDETMDAWKASGVLGVMLNGLQQRQNLEGTPVTPAFEPQDEKQSAAMTLGLLSSGMTPIGQSATFNDVSLKPSEPPLPTLGGFGGPETNPGASSIFNNMFGQMPDMQVNLDWDAWDNYIQGGTLDTSATWWTPMDIQQNSGPLSPSQLPATQSNPTERIRTVPRTTNLFPNNGYENDGLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>C8VP38</accession>
    <name>C8VP38_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_11313</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF85466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468725.1">
        <property type="nucleotide sequence ID" value="XM_050612855.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VP38"/>
    <dbReference type="GeneID" id="74896917"/>
    <dbReference type="KEGG" id="ani:ANIA_11313"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN11313"/>
    <dbReference type="HOGENOM" id="CLU_187027_0_0_1"/>
    <dbReference type="InParanoid" id="C8VP38"/>
    <dbReference type="OMA" id="EKEMTHE"/>
    <dbReference type="OrthoDB" id="4159814at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF85466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="82" mass="9619" checksum="A58205F6D1DB9D4C" modified="2009-11-03" version="1">MALTKEVQILIVIVGCVVSVLLGYSIHYLATNGFQGENEPKEMSHEQRQYMREFRLKQMNWMARDANAVWFVCMQQQQPQVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>C8VQ58</accession>
    <name>C8VQ58_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_10037</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF90083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050469314.1">
        <property type="nucleotide sequence ID" value="XM_050611044.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VQ58"/>
    <dbReference type="GeneID" id="74896163"/>
    <dbReference type="KEGG" id="ani:ANIA_10037"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN10037"/>
    <dbReference type="HOGENOM" id="CLU_2812335_0_0_1"/>
    <dbReference type="InParanoid" id="C8VQ58"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF90083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="67" mass="7650" checksum="BE1E6D649D5B45FE" modified="2009-11-03" version="1">MRWLGGSWGSSRRRGRGSHTSTRRTGDRAYFRGSDQWVNWMGVLFGFGWGFLTLLAVCNIVCPVREP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>C8VQI5</accession>
    <name>C8VQI5_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">General transcription and DNA repair factor IIH subunit TFB4</fullName>
            <shortName evidence="14">TFIIH subunit TFB4</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13 14">RNA polymerase II transcription factor B subunit 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">ANIA_00138</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="17">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 14">Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module TFIIK controls the initiation of transcription.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Component of the 7-subunit TFIIH core complex composed of XPB/SSL2, XPD/RAD3, SSL1, TFB1, TFB2, TFB4 and TFB5, which is active in NER. The core complex associates with the 3-subunit CTD-kinase module TFIIK composed of CCL1, KIN28 and TFB3 to form the 10-subunit holoenzyme (holo-TFIIH) active in transcription.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the TFB4 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF90125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050469322.1">
        <property type="nucleotide sequence ID" value="XM_050611054.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VQI5"/>
    <dbReference type="FunCoup" id="C8VQI5">
        <property type="interactions" value="1127"/>
    </dbReference>
    <dbReference type="STRING" id="227321.C8VQI5"/>
    <dbReference type="GeneID" id="2875918"/>
    <dbReference type="KEGG" id="ani:ANIA_00138"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN0138"/>
    <dbReference type="eggNOG" id="KOG2487">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040211_0_0_1"/>
    <dbReference type="InParanoid" id="C8VQI5"/>
    <dbReference type="OMA" id="QGCDITS"/>
    <dbReference type="OrthoDB" id="17307at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000084">
        <property type="entry name" value="Transcription factor TFIIH subunit Tfb4, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004600">
        <property type="entry name" value="TFIIH_Tfb4/GTF2H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12831:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12831">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIH TFIIH , POLYPEPTIDE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03850">
        <property type="entry name" value="Tfb4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11 14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 14" id="KW-0804">Transcription</keyword>
    <keyword evidence="9 14" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8 14" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="86"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="179"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="370"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="184"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00033341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU368090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CBF90125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="392" mass="42074" checksum="6243AC65E7832B7E" modified="2009-11-03" version="1">MNAVDATEHYGTSAHDPAPSLLTVIIDTNPHAWALLEQNEKNQLPFSTALANILVFLNAHLACNYANEVAVVASHTHKAAWLYPSPNSPTTSADSDGDVTMSNNNHMSTGGGSGKPSQVNKYRPFRIVEEQVTSNLRHLVDSTNRDDLDSGASTMMAGALTLALSHINRRTIAWAEAHGGGDASSFSRSGDPDTSTTSMIARRSTTTTATNDGAAEGLQSRILIISVSSATGSAHQYIPIMNGIFACQRLHIPIDVCKLSGDAVFLQQASDATKGIYMSLSEPRGLLQYLMMAFLPDQRSRKHLILPTRVDVDFRAACFCHRRVVDIGFVCSICLSIFCEPPENGDCLTCGTHLDTGDYGAKPAVVVRKKKKKKIRPNGVSATPTPTPTPGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>C8VSS2</accession>
    <name>C8VSS2_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nuclear localization protein, putative (AFU_orthologue AFUA_1G10600)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ANIA_01219</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF87911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050469018.1">
        <property type="nucleotide sequence ID" value="XM_050613185.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VSS2"/>
    <dbReference type="STRING" id="227321.C8VSS2"/>
    <dbReference type="GeneID" id="2876996"/>
    <dbReference type="KEGG" id="ani:ANIA_01219"/>
    <dbReference type="eggNOG" id="ENOG502R38T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013061_1_0_1"/>
    <dbReference type="InParanoid" id="C8VSS2"/>
    <dbReference type="OMA" id="GPMQPGH"/>
    <dbReference type="OrthoDB" id="5598844at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016586">
        <property type="term" value="C:RSC-type complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013933">
        <property type="entry name" value="CRC_Rsc7/Swp82"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22597:SF5">
        <property type="entry name" value="LOCALIZATION PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G10600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22597">
        <property type="entry name" value="POLYCOMB GROUP PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08624">
        <property type="entry name" value="CRC_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="431"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="28"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="61"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
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            <end position="114"/>
        </location>
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            <begin position="115"/>
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        </location>
    </feature>
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            <begin position="146"/>
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        </location>
    </feature>
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            <begin position="436"/>
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        </location>
    </feature>
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            <begin position="467"/>
            <end position="482"/>
        </location>
    </feature>
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        <location>
            <begin position="489"/>
            <end position="498"/>
        </location>
    </feature>
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            <begin position="521"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
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            <begin position="539"/>
            <end position="551"/>
        </location>
    </feature>
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            <end position="582"/>
        </location>
    </feature>
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        </location>
    </feature>
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        <location>
            <begin position="652"/>
            <end position="692"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBF87911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="692" mass="75741" checksum="EDA87EE8979DB4D7" modified="2009-11-03" version="1">MYGTSHSVSAPMNGIGGDLVDGSGTIDPAALNNTNVPVVLPTPPYGAADASTTPRGVKRARTPEQRGAPRDGDQDDDEHGRRKRGRPPKTPRPSTSDSSNNPQLQTPQMQPQQLHGSPTNASPPSGSPPEKTTPSKAPLVKALPTVRDHTTDQLNEARDEYIPKEFDEAGEKKVDENGVLQGDREYRCRTFTVPLRGKKLFMLATECARVLSYRDSYLLFNKNRSLHKIIATQLEKDDLIQQDILPYSYRSRQIAIVSARSMFRQFGSRVIVNGRRVRDDYWESKARKQGFTEDDLAGEKRPGGAKAREAAAEAANAANMLPTLAHGDVIYSNALENVPSNLSLGSGASMSQPLPMIHMATTTDDPRLREYNSMPRLRQELTGQPYQDRSQPSSAAEILNQATHTAEFNKILTNQRNFRQKGLDEFYAKQREAPVSTAQSQPEPTTSASHPMQSPRLSAASVLSSTPTQPNMMPQAQMMPSQAGFQPPTMHQQPQVAQSPIRAMPPVRPDLMHQRSNPAIAPQAGPYGYPPQQQQMWGQPPPQPQASPLPSNPQGVPQYPSQMQQQPGSQSQQAQHQQSPSPLTHNLPQQHPSQSPRNQVRPGVPQMPQSFAMHQPQTPQQQPMASMGFPGGGPYPTMAARGMYPSQHGPAGQPFMPGTQQPGMGMGMNPAMPGWPGQPMQPGHPQPGWSTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>C8VTX4</accession>
    <name>C8VTX4_EMENI</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ANIA_11288</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF88285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VTX4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN11288"/>
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    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF88285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="19" mass="2102" checksum="75C8C0171D2BF4EB" modified="2009-11-03" version="1">MLEPVESAECEILTCPCCM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>C8VUV3</accession>
    <name>C8VUV3_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ANIA_00208</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF89972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050469298.1">
        <property type="nucleotide sequence ID" value="XM_050611025.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VUV3"/>
    <dbReference type="STRING" id="227321.C8VUV3"/>
    <dbReference type="GeneID" id="2875985"/>
    <dbReference type="KEGG" id="ani:ANIA_00208"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN0208"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_0_2_1"/>
    <dbReference type="InParanoid" id="C8VUV3"/>
    <dbReference type="OMA" id="GICAKME"/>
    <dbReference type="OrthoDB" id="2250022at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF78">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01370)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="212"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="50"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBF89972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="325" mass="35517" checksum="5511F2D4BDCE6CF5" modified="2009-11-03" version="1">MDGHEAIKQKSSTAIATGDILRSENALASPLSEDEKRNEKKLVLKIDLLILPMIAFSFYLSIIDRGNYGAARLQHLESDVHMSGSEFQAALSIFYVGTILFGVPSNMLLNHFGRQSLHIGLAVLFWGTVTSCTAAVNNFEWMMACRTILGIADKGSSMCGNPILPLKMVKKIELSFRISICLSAGLVAAASGPLIAAGILNGLDGLRGLSAWRWLYLIEGIASICAGLALVAFLPDYPHTWAALTPHMRETNLTNEYRSYSASNIRRPETNLDGAKILALDGVKLALRDEKLYILTFLQLCTIICIESQSFYPTMTATLGYSHVI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2012-02-22" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>G5EAZ2</accession>
    <accession>C8V649</accession>
    <name>THI4_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thiamine thiazole synthase</fullName>
            <ecNumber evidence="1">2.4.2.60</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Thiazole biosynthetic enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">thiA</name>
        <name type="synonym">thi4</name>
        <name type="synonym">thiF</name>
        <name type="ORF">AN3928</name>
    </gene>
    <organism>
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in biosynthesis of the thiamine precursor thiazole. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylic acid (ADT), an adenylated thiazole intermediate. The reaction includes an iron-dependent sulfide transfer from a conserved cysteine residue of the protein to a thiazole intermediate. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme. May have additional roles in adaptation to various stress conditions and in DNA damage tolerance.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[ADP-thiazole synthase]-L-cysteine + glycine + NAD(+) = [ADP-thiazole synthase]-dehydroalanine + ADP-5-ethyl-4-methylthiazole-2-carboxylate + nicotinamide + 3 H2O + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:55708"/>
            <dbReference type="Rhea" id="RHEA-COMP:14264"/>
            <dbReference type="Rhea" id="RHEA-COMP:14265"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:90873"/>
            <dbReference type="ChEBI" id="CHEBI:139151"/>
            <dbReference type="EC" id="2.4.2.60"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="1">Binds 1 Fe cation per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homooctamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="1">During the catalytic reaction, a sulfide is transferred from Cys-220 to a reaction intermediate, generating a dehydroalanine residue.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the THI4 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.60" evidence="1"/>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF75074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AACD01000064">
        <property type="protein sequence ID" value="EAA59237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_661532.1">
        <property type="nucleotide sequence ID" value="XM_656440.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G5EAZ2"/>
    <dbReference type="SMR" id="G5EAZ2"/>
    <dbReference type="FunCoup" id="G5EAZ2">
        <property type="interactions" value="817"/>
    </dbReference>
    <dbReference type="STRING" id="227321.G5EAZ2"/>
    <dbReference type="EnsemblFungi" id="CBF75074">
        <property type="protein sequence ID" value="CBF75074"/>
        <property type="gene ID" value="ANIA_03928"/>
    </dbReference>
    <dbReference type="GeneID" id="2873351"/>
    <dbReference type="KEGG" id="ani:ANIA_03928"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN3928"/>
    <dbReference type="eggNOG" id="KOG2960">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053727_0_0_1"/>
    <dbReference type="InParanoid" id="G5EAZ2"/>
    <dbReference type="OMA" id="MFPRIVV"/>
    <dbReference type="OrthoDB" id="410463at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160205">
        <property type="term" value="F:cysteine-dependent adenosine diphosphate thiazole synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052837">
        <property type="term" value="P:thiazole biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03158">
        <property type="entry name" value="THI4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027495">
        <property type="entry name" value="Sti35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002922">
        <property type="entry name" value="Thi4_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00292">
        <property type="entry name" value="sulfide-dependent adenosine diphosphate thiazole synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43422">
        <property type="entry name" value="THIAMINE THIAZOLE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43422:SF3">
        <property type="entry name" value="THIAMINE THIAZOLE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01946">
        <property type="entry name" value="Thi4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000415874" description="Thiamine thiazole synthase">
        <location>
            <begin position="1"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="107"/>
            <end position="108"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="289"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="299"/>
            <end position="301"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="2,3-didehydroalanine (Cys)" evidence="1">
        <location>
            <position position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03158"/>
        </source>
    </evidence>
    <sequence length="331" mass="35616" checksum="2129CB2DCBD53160" modified="2011-12-14" version="1">MSPPAAIFEPTVAPTGIKGKVVVPETATIPGDSQTKLLDHFGGKWDNFKFAPIRESQVSRAMTRRYFQDLDRYAESDVVIVGAGSCGLSTAYVLAKARPDLKIAIIEASVSPGGGAWLGGQLFSAMVMRRPAELFLNELGVPYEEDPDMPNYVVVKHASLFTSTLLSKVLSFPNVKLFNATCVEDLVTRPGPNGNAQEVQIAGVVTNWTLVTLHHDDHSCMDPNTINAPVIISTTGHDGPFGAFSAKRLVSMTTIDKLGGMRGLDMNSAEDAIVKNTREVAKGLIIGGMELSEIDGFNRMGPTFGAMVLSGVKAAEEALRVFDDRKRECAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-12-14" modified="2025-10-08" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>G5EB07</accession>
    <accession>C8VIG3</accession>
    <name>G5EB07_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GATA-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">nsdD</name>
        <name evidence="9" type="ORF">ANIA_03152</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF83303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_660756.1">
        <property type="nucleotide sequence ID" value="XM_655664.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G5EB07"/>
    <dbReference type="STRING" id="227321.G5EB07"/>
    <dbReference type="GeneID" id="2874110"/>
    <dbReference type="KEGG" id="ani:ANIA_03152"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN3152"/>
    <dbReference type="eggNOG" id="KOG1601">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029475_1_0_1"/>
    <dbReference type="InParanoid" id="G5EB07"/>
    <dbReference type="OMA" id="HYATRAH"/>
    <dbReference type="OrthoDB" id="2162994at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043941">
        <property type="term" value="P:positive regulation of sexual sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000043">
        <property type="entry name" value="Sexual development transcription factor NsdD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47172:SF24">
        <property type="entry name" value="GATA ZINC FINGER DOMAIN-CONTAINING PROTEIN 14-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47172">
        <property type="entry name" value="OS01G0976800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="8">
        <location>
            <begin position="399"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="15"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="216"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="378"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="440"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="24"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="64"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="141"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="221"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBF83303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="461" mass="49251" checksum="37C3AAB57ABC2F87" modified="2011-12-14" version="1">MGSLEAGHRHRDHLPAIGFIGSRGPTTSPAPLVSPTTMYPNNPLPYSYSTTPANVGPGYASPPEPRRAEDEKEKAPRQSLPSIHEALGNDNPLPYPPAPTSAAPQQPNSAPPPHHLPNFGRSSAEGPSGPPNPFSNGSSFLRESSSSHQPQLQAEPSRSSLASLNTTDSRNASLQSISSGKSPTQSASTVMTSVSGSQTGTGYDYNAPPSAGSVASPNGYSGFSQPFPFQSQPPPGAPVYPAASYDSRPYEMKGGVTGSFGHQGDSAKRHLDVYDIESSLTEMVDLNTRALDFSRHYANRAHQSRSGAVVGSALPSLHEVEEMLNIQRRNHDALMRIRAVVFSQEHAMAEQVAQRKAFKFGGAHDDDHRMAMYQEEFKSSGGFGPDSKKRRGKAAPPGRCHSCNRAETPEWRRGPDGARTLCNACGLHYAKLTRKMGAKQAAGLGSNLKPKTLDSVSPRSH</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2025-04-09" version="100" xmlns="https://uniprot.org/uniprot">
    <accession>Q00648</accession>
    <accession>C8V452</accession>
    <accession>Q5B757</accession>
    <name>CSN7_EMENI</name>
    <protein>
        <recommendedName>
            <fullName>COP9 signalosome complex subunit 7</fullName>
            <shortName>CSN complex subunit 7</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">csnG</name>
        <name type="synonym">acoB</name>
        <name type="synonym">csn7</name>
        <name type="ORF">AN3623</name>
    </gene>
    <organism>
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1995" name="Microbiology" volume="141" first="1821" last="1828">
            <title>A pre-induction sporulation gene from Aspergillus nidulans.</title>
            <authorList>
                <person name="Lewis C."/>
                <person name="Champe S.P."/>
            </authorList>
            <dbReference type="PubMed" id="7551046"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA]</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="8089" last="8094">
            <title>An eight-subunit COP9 signalosome with an intact JAMM motif is required for fungal fruit body formation.</title>
            <authorList>
                <person name="Busch S."/>
                <person name="Schwier E.U."/>
                <person name="Nahlik K."/>
                <person name="Bayram O."/>
                <person name="Helmstaedt K."/>
                <person name="Draht O.W."/>
                <person name="Krappmann S."/>
                <person name="Valerius O."/>
                <person name="Lipscomb W.N."/>
                <person name="Braus G.H."/>
            </authorList>
            <dbReference type="PubMed" id="17470786"/>
            <dbReference type="DOI" id="10.1073/pnas.0702108104"/>
        </citation>
        <scope>IDENTIFICATION IN THE CSN COMPLEX</scope>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the COP9 signalosome (CSN) complex that acts as an regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunit of SCF-type E3 ubiquitin-protein ligase complexes (By similarity). The CSN complex seems to link protein degradation to sexual development. May be required for sporulation only at elevated temperatures.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the COP9 signalosome (CSN) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="tissue specificity">
        <text evidence="5">Present in uninduced vegetative hyphae, induced conidiating cultures and in both conidiospores and ascospores.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the CSN7/EIF3M family. CSN7 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="U18265">
        <property type="protein sequence ID" value="AAA85690.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AACD01000061">
        <property type="protein sequence ID" value="EAA59831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF75752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_661227.1">
        <property type="nucleotide sequence ID" value="XM_656135.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q00648"/>
    <dbReference type="SMR" id="Q00648"/>
    <dbReference type="DIP" id="DIP-60931N"/>
    <dbReference type="IntAct" id="Q00648">
        <property type="interactions" value="4"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q00648"/>
    <dbReference type="EnsemblFungi" id="CBF75752">
        <property type="protein sequence ID" value="CBF75752"/>
        <property type="gene ID" value="ANIA_03623"/>
    </dbReference>
    <dbReference type="KEGG" id="ani:ANIA_03623"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN3623"/>
    <dbReference type="eggNOG" id="KOG3250">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054426_0_0_1"/>
    <dbReference type="InParanoid" id="Q00648"/>
    <dbReference type="OMA" id="GTYKQFR"/>
    <dbReference type="OrthoDB" id="10265275at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070791">
        <property type="term" value="P:cleistothecium development"/>
        <property type="evidence" value="ECO:0000353"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045237">
        <property type="entry name" value="COPS7/eIF3m"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15350:SF5">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15350">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 7/DENDRITIC CELL PROTEIN GA17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22061">
        <property type="entry name" value="CSN7_HB_subdom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0736">Signalosome</keyword>
    <feature type="chain" id="PRO_0000314736" description="COP9 signalosome complex subunit 7">
        <location>
            <begin position="1"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="PCI" evidence="2">
        <location>
            <begin position="4"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="233"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="276"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="315"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="17470786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="7551046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="6"/>
    <sequence length="327" mass="35332" checksum="8E4472488AE01893" modified="1996-11-01" version="1">MDQVHHRALDALQSFIALTDSSSATSPRYIASIITNATSSPHTYVFAELLERPAVQALRSPDTPAEFQSYLTLLEIFAWGTWQDYQQTPNLPPLSEEQARKLRLLTLLSLASTIKPLTYEALMTSLSLSAPSELESLVTTAIYSSLITGRLSPATNPPTVNVTSVAPLRDVKPSSLPTMISTLTAWEARCGSVISDIETEIAKIRADSAQRRQKEHARAVAIEKTLEKWNAEGGEQLQGGNPGQGQGQGQGGLGKNAGWKPRDLSTAMFERGFFGGGSNKREFDDDGYFDGGSSDFDQHGSGMDIDEGAGARASGARHSKRFLGKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="109" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AQA4</accession>
    <accession>C8V9W7</accession>
    <name>Q5AQA4_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ER-Golgi SNARE complex subunit Sed5 (Eurofung)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ANIA_09526</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF76619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="XP_868908.1">
        <property type="nucleotide sequence ID" value="XM_863815.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AQA4"/>
    <dbReference type="FunCoup" id="Q5AQA4">
        <property type="interactions" value="744"/>
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    <dbReference type="STRING" id="227321.Q5AQA4"/>
    <dbReference type="GeneID" id="3684125"/>
    <dbReference type="KEGG" id="ani:ANIA_09526"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN9526"/>
    <dbReference type="eggNOG" id="KOG0812">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_044998_0_1_1"/>
    <dbReference type="InParanoid" id="Q5AQA4"/>
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        <property type="component" value="Chromosome III"/>
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        <property type="term" value="C:cis-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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        <property type="term" value="C:Golgi membrane"/>
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        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0000318"/>
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    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
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        <property type="project" value="GO_Central"/>
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    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="AspGD"/>
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        <property type="term" value="P:intracellular protein transport"/>
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        <property type="term" value="P:regulation of inclusion body assembly"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0000318"/>
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        <property type="term" value="P:vesicle fusion with Golgi apparatus"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd15844">
        <property type="entry name" value="SNARE_syntaxin5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.70:FF:000007">
        <property type="entry name" value="ER-golgi SNARE complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021538">
        <property type="entry name" value="Syntaxin-5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF3">
        <property type="entry name" value="SYNTAXIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11416">
        <property type="entry name" value="Syntaxin-5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
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    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="323"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="10">
        <location>
            <begin position="252"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="24"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="177"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="28"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
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            <begin position="177"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="8">
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            <begin position="214"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CBF76619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="344" mass="37853" checksum="A055C7DDC17F96FB" modified="2005-04-26" version="1">MTGPTIQDRTSEFQAILGQAQKRAASSKVGSQRQALLTDSQRQQANGSPNGTAAGGKRRSEFARRAAEIGRGITATTAKLRRLAELAKRKTLFDDRPVEISELTYVIKQDLASLNQQIASLQALTLSQHPKSNRSKTDQEGEHNDNVVVMLQGKLADVGANFKDVLEVRTKNIQASRSRTENFVSSVSSKSQAALDPQRSDSPLYPSGRRTPQPGGSSDLLTLEPSNPSPLGRPSMQSDQQLLMMEEAESSNSYIQSRGEAIDAIERTINELGGIFGQLAQMVSEQSEMIQRIDANTEDVVDNVQGAQRELMKYWTRVSGNRWLIAKMFGVLMIFFLLWVLISG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AQB5</accession>
    <accession>C8VMM3</accession>
    <name>Q5AQB5_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_09515</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF84978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468657.1">
        <property type="nucleotide sequence ID" value="XM_050612778.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AQB5"/>
    <dbReference type="STRING" id="227321.Q5AQB5"/>
    <dbReference type="GeneID" id="3684114"/>
    <dbReference type="KEGG" id="ani:ANIA_09515"/>
    <dbReference type="eggNOG" id="ENOG502S5IQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070610_4_0_1"/>
    <dbReference type="InParanoid" id="Q5AQB5"/>
    <dbReference type="OMA" id="WNCKIRT"/>
    <dbReference type="OrthoDB" id="10254720at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="84"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF84978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="231" mass="24671" checksum="9DC122D3A7C9507B" modified="2005-04-26" version="1">MSWKDADAGPCPSSQKRIRGLALPPPISGSEVSKWMAPANEETGRVPRPQPLPASPHPSSGIPSAPDRDGDAVEPADSNPGEISANPSSASSSRSQLESPNLAPKERPVSGIVPPYWSHHRNASRASQISADGGPAITLEDHTEDPNSETSRGLWAKSVTIDDHVVVQGKSGVGAYVVWNCKIRTLEGGTITVRMRYSYGSAIISTPSQRYPRRVFYSSFGHLSLNLAKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AQF4</accession>
    <accession>C8VEM1</accession>
    <name>Q5AQF4_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ANIA_09476</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF80690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_868858.1">
        <property type="nucleotide sequence ID" value="XM_863765.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AQF4"/>
    <dbReference type="GeneID" id="3684073"/>
    <dbReference type="KEGG" id="ani:ANIA_09476"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN9476"/>
    <dbReference type="HOGENOM" id="CLU_1402420_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AQF4"/>
    <dbReference type="OrthoDB" id="4496038at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF80690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="194" mass="21844" checksum="A45C4AE2BDDA7B31" modified="2005-04-26" version="1">MCTDHKAPFAGIARMPLKALQGNKSNDVPFQMTRRHCTYKPETSFSADNQISNDMADEDQPDEPATMENILPGLLRQIREEITKQVRDESITPHVQETISWEDSTLAAELWARITSTYGLSTAEERLMTVKALLDINPQGNYPAMIRDPQQIGAKLKCLWQQSFIYTKLDKFFSCGRGPIKNLDIAALADQLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AQG4</accession>
    <accession>C8VRV5</accession>
    <name>Q5AQG4_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PhoD-like phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_09466</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF87625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_868848.1">
        <property type="nucleotide sequence ID" value="XM_863755.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AQG4"/>
    <dbReference type="FunCoup" id="Q5AQG4">
        <property type="interactions" value="82"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5AQG4"/>
    <dbReference type="GeneID" id="3684063"/>
    <dbReference type="KEGG" id="ani:ANIA_09466"/>
    <dbReference type="eggNOG" id="ENOG502QPI0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000998_3_0_1"/>
    <dbReference type="InParanoid" id="Q5AQG4"/>
    <dbReference type="OMA" id="GPNLWND"/>
    <dbReference type="OrthoDB" id="9999821at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd07389">
        <property type="entry name" value="MPP_PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.70">
        <property type="entry name" value="PhoD-like phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018946">
        <property type="entry name" value="PhoD-like_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038607">
        <property type="entry name" value="PhoD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043904">
        <property type="entry name" value="PhoD_2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46689">
        <property type="entry name" value="MEMBRANE PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46689:SF3">
        <property type="entry name" value="PHOD-LIKE PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19050">
        <property type="entry name" value="PhoD_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PhoD-like phosphatase" evidence="2">
        <location>
            <begin position="9"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="PhoD-like phosphatase" evidence="2">
        <location>
            <begin position="203"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="PhoD-like phosphatase" evidence="2">
        <location>
            <begin position="285"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="444"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="524"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="540"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="552"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF87625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="562" mass="62750" checksum="692B0DD71B244F9B" modified="2005-04-26" version="1">MDAWIGPNLWKDVLRVHAMKPFHVMIGGGDQIYNDGIRVDGPLKEWTSIANPHKRRTHSFDNNLRAACDDYYFANYVRWYSTEPFKEANGRIPQINIWDDHDIIDGFGSYTDHFMKCSVFRGIGGVAFKYYCLFQHHIAPPKSTYTTDAPQTMQAVNGTAGADPRQLEDTFVLEDQTEDNSWIVGKRPGPYVEEKSRNLYMRLGKRMAFIGVDARTERTRHQVNYPDTYDLIFSRLEQEVAAANGDIKHLIVLLGVPIAYPRLAWLENILSSPIIAPIRLLNKRFGLAGGFFNQFDGQVDLLDDLDDHYTARQHKRERRIFIQRLQDFSKAHSIRVTILGGDVHLAAIGRFYSNPKLGVHSENDPRYMVNIVSSAITNKPPPKAVANLLARRNKIHHLDTDTDETLMDFFDGQPGGVDKSASWNKVTMPSRNYACITEIETPAANGDGAQQNGVTLPIPKDGHSPLHTGESTAGSAHSAADGVSSASTLHGGLNVAIRVEINPQNRDGAAHGYGFSIPALSYVQTEDDARPRPQSRSRSLHAAAASIRSHSNQREARPRTST</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="100" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AQV6</accession>
    <accession>C8VQS7</accession>
    <name>Q5AQV6_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Amidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_09324</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF87402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_682593.1">
        <property type="nucleotide sequence ID" value="XM_677501.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AQV6"/>
    <dbReference type="STRING" id="227321.Q5AQV6"/>
    <dbReference type="GeneID" id="2867793"/>
    <dbReference type="KEGG" id="ani:ANIA_09324"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN9324"/>
    <dbReference type="eggNOG" id="KOG1211">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009600_18_0_1"/>
    <dbReference type="InParanoid" id="Q5AQV6"/>
    <dbReference type="OMA" id="NPLGAWY"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895:SF171">
        <property type="entry name" value="AMIDASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="1">
        <location>
            <begin position="92"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="Amidase" evidence="1">
        <location>
            <begin position="218"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF87402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="563" mass="59872" checksum="4BB4A595FCDEBB25" modified="2005-04-26" version="1">MPQPRSPVTADDLRNLAARYNITIKPGPEEDAYLLLLQSAEALHRIIRDTTDYVHPDLAPVPTRAPRGFRRLSSAENPLNAWSHVSNITAANPINTLLAGRTVVVKDNVSVAGLPTTLGIPAWLHSKAGEYQPSPIDATVVRRLFFAGATLKGTAVCESYSAAPVSFTSATGAVHNPWARGHTAGGSSSGCAALIGQRAVLKESGSAINGPHQGSPTVELAVGGDQGGSIRVPAAYTGVYGLKPTHGLVPYTGAVSLTPMIDHLGPMATKIEDIALMLKVMAGYDGLDSRMTPESPMPGQVKDYPSLVADFIKSAKSTTLQKPVMKVGVLREAFDFPGLSAEVRDTVLQNAKAYFSAAGADILEVSVPMHREAPAIWTVAARTSLADYGLAMKPPGYLSYAPDHIDTQWPPTQEMYDYLSAGNPTIMNLIFSTDYLRETFGTSVEFKGHRKVFELRAAYDAVLSDVDVLITPTVPTVAFEFPSSTKGGTEWGDIGERVTAAVGLSYNTCPFNVTGHPAMNVPCGLGGSDGKKLPIGMQVIGKRWDDEAVLKAAALFEMGRDGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AR41</accession>
    <accession>C8VPX7</accession>
    <name>Q5AR41_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ANIA_09239</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF87226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_682508.1">
        <property type="nucleotide sequence ID" value="XM_677416.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AR41"/>
    <dbReference type="GeneID" id="2867904"/>
    <dbReference type="KEGG" id="ani:ANIA_09239"/>
    <dbReference type="eggNOG" id="ENOG502SKGQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_834264_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AR41"/>
    <dbReference type="OrthoDB" id="4851849at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42037">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42037:SF1">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF87226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="333" mass="37939" checksum="0E4B268CEBDA0CD2" modified="2005-04-26" version="1">MKQGNSLTLVPKQIGPPRLDPYGRLLARFYESLFFLTSLGRTQGEHTPEPPVLDIHQECRRRFLKNLSYICDFRKGGQACTAIAVEDRVDCYRFWVASNMNVNKAVAFIREILAMLHDRHLDASNNESMIEASLIQRCVEFAAKRIDSEGRFLRIMANRCILMLEDEESEAGMTFFLSNLLERALSCSRNITLCRFLYDQRHSAAMKELSARAISDKGRPGRAEEDSCFSSARHHIGRLIHHIRAPIELAQDSRHLMYLTDAYTVCPVSPCSAVSCPVSDMHTNLQGILNWMFMADDEDRVAVGDGLVYINKTRPIFDTFLAEYNGRDRQVHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="107" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ARE0</accession>
    <accession>C8VK59</accession>
    <name>Q5ARE0_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS transporter Fmp42, putative (AFU_orthologue AFUA_7G01670)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ANIA_09140</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC43A transporter (TC 2.A.1.44) family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF82467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_682409.1">
        <property type="nucleotide sequence ID" value="XM_677317.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ARE0"/>
    <dbReference type="FunCoup" id="Q5ARE0">
        <property type="interactions" value="52"/>
    </dbReference>
    <dbReference type="GeneID" id="2868101"/>
    <dbReference type="KEGG" id="ani:ANIA_09140"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN9140"/>
    <dbReference type="eggNOG" id="ENOG502QRYG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014401_1_0_1"/>
    <dbReference type="InParanoid" id="Q5ARE0"/>
    <dbReference type="OMA" id="CNILQQV"/>
    <dbReference type="OrthoDB" id="330047at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052599">
        <property type="entry name" value="SLC43A_AATransporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20772">
        <property type="entry name" value="PROTEIN FMP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20772:SF2">
        <property type="entry name" value="PROTEIN FMP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="278"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="312"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="453"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="495"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="544"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="573"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="612"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="14"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="406"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="674"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="49"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="675"/>
            <end position="689"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBF82467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="698" mass="76433" checksum="826B4ECB9158DB3A" modified="2005-04-26" version="1">MSLPRVSYLESWENNPALVRRHQDRDQSPGRAVHRDDDEESYHDIPDSSVASSFPSTTDLPSSRHRLNFNPYGGLGWTQAVGAEDDTNVLSKASSIVSRQGQADRTAEAGRVRQSGDSQLETWGPLETTGAFEVSKAKRVVQVSFAVIYCFLAAGIVFGFAAIKPVFIREGVYHDFCFEGEDICYRQELSLNLMFTIAAVATNVSALPVGTILDTYGPRVCGIIGSTLLFTGALLLALAKRLPFDAYVPGYLLLALGGPFIFISSFQLSNTFPARSGLILSALTGAFDASSALFLIFRIINEKTNGVFSTQKFFLVYLVVPIFIMIAQLSVMPKTSYKTAGELVQQAEDHIIAEVTDRVDEQILDRDEGERQRNDRRMHRQSIVSKIQDLLADEANASTINDLGLALNDGRDTNEANTTPARPGPSVPNKHMGGGVWGAMHGYSAVEQIRSPWFVLITVFTVLQMLRINYFVASIRQQYEYLFGSAEDARHINELFDFLLPLGGLCAVPFIGTILDNASTPFVLFVLAATATVIGALGCIPNSYLAAYANIILFVIYRPFYYTAVSDYAAKVFGFHTFGKVYGLIICVAGLGNFAQAGLDALTFTVFNRNPIPVNLILTSFTAVAGFALMLFVGRKAAVMSASNESETRADPEVASLIHNYDGVAARDWERERQPLLSPRSVPRPQPQSASYGSMRSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ARK7</accession>
    <accession>C8VH74</accession>
    <name>Q5ARK7_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_09073</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF82604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_682342.1">
        <property type="nucleotide sequence ID" value="XM_677250.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ARK7"/>
    <dbReference type="GeneID" id="2868022"/>
    <dbReference type="KEGG" id="ani:ANIA_09073"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN9073"/>
    <dbReference type="HOGENOM" id="CLU_1740507_0_0_1"/>
    <dbReference type="InParanoid" id="Q5ARK7"/>
    <dbReference type="OMA" id="ATADCIT"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010346605" evidence="2">
        <location>
            <begin position="20"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF82604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="150" mass="14664" checksum="4DFF665252F13B68" modified="2005-04-26" version="1">MQLLKTILLFSAAFTPAFAAVANGGSGETESFTSTRTTTVTVTVKTSTTATPTPTYTPTSTSTPVIVTPSSTATPTPSPCSSFVITKIHSSTIAPSYAPSSASTGGFASGSSTVSASPSQTPFTGAAVPGAKFSGAGVVGAGLAAMAFLL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2010-04-20" modified="2026-01-28" version="128" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ARL6</accession>
    <accession>C8VH83</accession>
    <name>XYL2_EMENI</name>
    <protein>
        <recommendedName>
            <fullName>Probable D-xylulose reductase A</fullName>
            <ecNumber>1.1.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Xylitol dehydrogenase A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">xdhA</name>
        <name type="ORF">AN9064</name>
    </gene>
    <organism>
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Xylitol dehydrogenase which catalyzes the conversion of xylitol to D-xylulose. Xylose is a major component of hemicelluloses such as xylan. Most fungi utilize D-xylose via three enzymatic reactions, xylose reductase (XR), xylitol dehydrogenase (XDH), and xylulokinase, to form xylulose 5-phosphate, which enters pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>xylitol + NAD(+) = D-xylulose + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20433"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17140"/>
            <dbReference type="ChEBI" id="CHEBI:17151"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text>Carbohydrate degradation; L-arabinose degradation via L-arabinitol; D-xylulose 5-phosphate from L-arabinose (fungal route): step 4/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.9"/>
    <dbReference type="EMBL" id="AACD01000169">
        <property type="protein sequence ID" value="EAA61897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF82620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_682333.1">
        <property type="nucleotide sequence ID" value="XM_677241.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ARL6"/>
    <dbReference type="SMR" id="Q5ARL6"/>
    <dbReference type="FunCoup" id="Q5ARL6">
        <property type="interactions" value="525"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5ARL6"/>
    <dbReference type="EnsemblFungi" id="CBF82620">
        <property type="protein sequence ID" value="CBF82620"/>
        <property type="gene ID" value="ANIA_09064"/>
    </dbReference>
    <dbReference type="KEGG" id="ani:ANIA_09064"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN9064"/>
    <dbReference type="eggNOG" id="KOG0024">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_11_5_1"/>
    <dbReference type="InParanoid" id="Q5ARL6"/>
    <dbReference type="OMA" id="FETWYAM"/>
    <dbReference type="OrthoDB" id="3941538at2759"/>
    <dbReference type="UniPathway" id="UPA00146">
        <property type="reaction ID" value="UER00577"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046526">
        <property type="term" value="F:D-xylulose reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003939">
        <property type="term" value="F:L-iditol 2-dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042732">
        <property type="term" value="P:D-xylose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019569">
        <property type="term" value="P:L-arabinose catabolic process to D-xylulose 5-phosphate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006062">
        <property type="term" value="P:sorbitol catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd05285">
        <property type="entry name" value="sorbitol_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000068">
        <property type="entry name" value="Sorbitol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045306">
        <property type="entry name" value="SDH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161:SF9">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0859">Xylose metabolism</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000393513" description="Probable D-xylulose reductase A">
        <location>
            <begin position="1"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="182"/>
            <end position="187"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="359" mass="38175" checksum="C5C720E33993C935" modified="2005-04-26" version="1">MSSQTPTAQNLSFVLEGIHRVKFEDRPIPKLKSPHDVIVNVKYTGICGSDVHYWDHGAIGQFVVKEPMVLGHESSGIVTQIGSAVTSLKVGDHVAMEPGIPCRRCEPCKAGKYNLCEKMAFAATPPYDGTLAKYYTLPEDFCYKLPESISLPEGALMEPLGVAVHIVRQANVTPGQTVVVFGAGPVGLLCCAVAKAFGAIRIIAVDIQKPRLDFAKKFAATATFEPSKAPATENATRMIAENDLGRGADVAIDASGVEPSVHTGIHVLRPGGTYVQGGMGRSEMNFPIMAACTKELNIKGSFRYGSGDYKLAVQLVASGQINVKELITGIVKFEDAEQAFKDVKTGKGIKTLIAGPGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="119" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ARP6</accession>
    <accession>C8VKR5</accession>
    <name>Q5ARP6_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Aldehyde dehydrogenase ALDH (AFU_orthologue AFUA_8G02310)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ANIA_09034</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF84421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_682303.1">
        <property type="nucleotide sequence ID" value="XM_677211.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ARP6"/>
    <dbReference type="STRING" id="227321.Q5ARP6"/>
    <dbReference type="GeneID" id="2868241"/>
    <dbReference type="KEGG" id="ani:ANIA_09034"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN9034"/>
    <dbReference type="eggNOG" id="KOG2450">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005391_0_1_1"/>
    <dbReference type="InParanoid" id="Q5ARP6"/>
    <dbReference type="OMA" id="VRHVMIK"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046394">
        <property type="term" value="P:carboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006598">
        <property type="term" value="P:polyamine catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000001">
        <property type="entry name" value="Aldehyde dehydrogenase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000026">
        <property type="entry name" value="Aldehyde dehydrogenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000012">
        <property type="entry name" value="Betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43720">
        <property type="entry name" value="2-AMINOMUCONIC SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43720:SF3">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE ALDH (AFU_ORTHOLOGUE AFUA_8G02310)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="5">
        <location>
            <begin position="28"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBF84421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="511" mass="54857" checksum="F8289110AAEA9E45" modified="2005-04-26" version="1">MADLFVDLVAPNGTHYSQPTGLFINNAFVASSGQTITSLDPATDKPIATVHAASAEDVDRAVIAARAALVHPSWKKLPGTERGQLMARLADLMEKNKELFATIDAWDNVLSLTEKSGKPYHIALSEDLVEAIGTIRYYSGWADKTFGQTISTTPAKFAYTIRQPVGVVGQIIPWNYPLSMACWKLGPALACGNTVVLKPAEQTPLSVLVLGSLIKEAGFPPGVVNIVNGYGREAGAALAGHPLIDKIAFTGSTVTAREIMKLAAGTLKNITLETGGKSPLLVFPDADLEQAVKWSHFGIMSNQGQICTATSRIYVHQDIFQLFLSKFKAAVETTSKIGDQWDESTFQGPQITRAQYDRILSYIETAKKGGMAVVTGGSAHAPSSEKNKDGYFIQPTVFTGTDDSHAIVREEVFGPVVVILPFASEEEAIRRANDTTYGLGAAVFTCDLERAHRVAAEIEAGMVWVNSSQDCDPRVPFGGVKQSGIGRELGEAGLEAYTQVKAVHVNMGNKL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-01-09" modified="2026-01-28" version="128" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ASA5</accession>
    <accession>C8V9K8</accession>
    <name>SET2_EMENI</name>
    <protein>
        <recommendedName>
            <fullName>Histone-lysine N-methyltransferase, H3 lysine-36 specific</fullName>
            <ecNumber evidence="2">2.1.1.359</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>SET domain-containing protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">set2</name>
        <name type="ORF">AN8825</name>
    </gene>
    <organism>
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Histone methyltransferase that trimethylates histone H3 'Lys-36' forming H3K36me3. Involved in transcription elongation as well as in transcription repression.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 7">
            <text>L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60324"/>
            <dbReference type="Rhea" id="RHEA-COMP:9785"/>
            <dbReference type="Rhea" id="RHEA-COMP:15536"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="2.1.1.359"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">The AWS and SET domains are necessary for transcription repression.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.359" evidence="2"/>
    <dbReference type="EMBL" id="AACD01000162">
        <property type="protein sequence ID" value="EAA60113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF77940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_682094.1">
        <property type="nucleotide sequence ID" value="XM_677002.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ASA5"/>
    <dbReference type="SMR" id="Q5ASA5"/>
    <dbReference type="FunCoup" id="Q5ASA5">
        <property type="interactions" value="100"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5ASA5"/>
    <dbReference type="EnsemblFungi" id="CBF77940">
        <property type="protein sequence ID" value="CBF77940"/>
        <property type="gene ID" value="ANIA_08825"/>
    </dbReference>
    <dbReference type="GeneID" id="2868338"/>
    <dbReference type="KEGG" id="ani:ANIA_08825"/>
    <dbReference type="eggNOG" id="KOG4442">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008492_0_1_1"/>
    <dbReference type="InParanoid" id="Q5ASA5"/>
    <dbReference type="OMA" id="AQSQPCY"/>
    <dbReference type="OrthoDB" id="422362at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ASU5</accession>
    <accession>C8VAD4</accession>
    <name>Q5ASU5_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ANIA_08635</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-beta-lactamase superfamily.</text>
    </comment>
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        <property type="protein sequence ID" value="CBF78286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_676812.1"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07730">
        <property type="entry name" value="metallo-hydrolase-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051013">
        <property type="entry name" value="MBL_superfamily_lactonases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42978:SF4">
        <property type="entry name" value="METALLO-BETA-LACTAMASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42978">
        <property type="entry name" value="QUORUM-QUENCHING LACTONASE YTNP-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="5">
        <location>
            <begin position="46"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBF78286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="317" mass="34799" checksum="60C82EE31C04254A" modified="2005-04-26" version="1">MSDTHAAVGLPATEAYVRLHLLNGGSMTAEYHKLHAGDAAEEFRLYNWAFFVQHTAQGRNVIWDVGMSSNSDDFPPVIGHGVIKEAKVLDPAESLTAQIQRRSGIMADQIDTVLLSHAHFDHCRPISRLFPNAIAYFGPGTFDFCSPGHFADPASPWDGRFFDPARATERCETLIGPWTPFGPFEHAIDFFGDGSFWVIQAPGHMPGNLCACARIESGEWVLLGSDCCHSRGLLEGAKEIATFPLPDGGTGCLHTDVAAAKDTLARLRVLQSQLGVHIALANDASWMEKEDDEVLMSLLDEKFQEDMRRALPLQEPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AT31</accession>
    <accession>C8VER9</accession>
    <name>Q5AT31_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">LTD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ANIA_08549</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF80779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_681818.1">
        <property type="nucleotide sequence ID" value="XM_676726.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AT31"/>
    <dbReference type="STRING" id="227321.Q5AT31"/>
    <dbReference type="GeneID" id="2868829"/>
    <dbReference type="KEGG" id="ani:ANIA_08549"/>
    <dbReference type="eggNOG" id="ENOG502SMSB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067370_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AT31"/>
    <dbReference type="OMA" id="SRLAYWV"/>
    <dbReference type="OrthoDB" id="2580841at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019268">
        <property type="entry name" value="DUF2278"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036415">
        <property type="entry name" value="Lamin_tail_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10042">
        <property type="entry name" value="DUF2278"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74853">
        <property type="entry name" value="Lamin A/C globular tail domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF80779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="399" mass="43771" checksum="9CA9ED4BCE7A0105" modified="2005-04-26" version="1">MPVDNYGVLKCRAITYKLEDGQQSPRAPQLSLYVRDTGSPTSQLNGCVHPSHLQEARAGLPVHRAAINITSGDLDDSRLAYWVNHQIGQNPIVNRLSQLEYGFHPVENNKTLGLDYIRDSLFTSTNGRLLPHDIPGQYTDIIDVLSPYIQHAVREKANLYLFGSESRSDTRGSAPVIHNIHMNQGNARKFRADDGVFQDGGLIFHFPCARPDSDTGCVEDRPRGEWLGIFLAFASQAVHTNPSSGHAISGVGWSDILRPDIIEEGVVIREARLHLDSSGTDADAVTDESETGARPCIGRRKSISLTVTLSNHTNRAVRLGDWTIRNRSGCVHTLPRGIALRPMVDQHFELGDYTLSEDGDTILLLNEHGLKVDGVSYNSAQEGMGLKGKGKGGSIVFVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ATF3</accession>
    <accession>C8VED3</accession>
    <name>Q5ATF3_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ANIA_08427</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF80526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_681696.1">
        <property type="nucleotide sequence ID" value="XM_676604.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ATF3"/>
    <dbReference type="GeneID" id="2868844"/>
    <dbReference type="KEGG" id="ani:ANIA_08427"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN8427"/>
    <dbReference type="HOGENOM" id="CLU_1378110_0_0_1"/>
    <dbReference type="InParanoid" id="Q5ATF3"/>
    <dbReference type="OrthoDB" id="10613705at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF80526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="198" mass="22325" checksum="A4E6EA3A8DC7488A" modified="2005-04-26" version="1">MNREEANGIWTTSASDSAAGIHPVPQDTNNLGQYTRNALLISDYGRTRPTLWQNMPQLDNEGAVIAWYNATFLWAPTPQPRGVIEANIATLNMIDPIQILINQNILHALAILHGTGRCNPAGYGISARTYFSMAWNRRRNPKLRIMHYICRECRKNRVFALERPKCPGLVAGASNKTHLDFIIRRDHSAFSQIDTDRA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2016-11-30" modified="2026-01-28" version="118" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ATG5</accession>
    <accession>C8VEB7</accession>
    <name>APDG_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Acyl-CoA dehydrogenase apdG</fullName>
            <ecNumber evidence="7">1.-.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Aspyridones biosynthesis protein G</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">apdG</name>
        <name type="ORF">AN8415</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2007" name="Nat. Chem. Biol." volume="3" first="213" last="217">
            <title>Genomics-driven discovery of PKS-NRPS hybrid metabolites from Aspergillus nidulans.</title>
            <authorList>
                <person name="Bergmann S."/>
                <person name="Schuemann J."/>
                <person name="Scherlach K."/>
                <person name="Lange C."/>
                <person name="Brakhage A.A."/>
                <person name="Hertweck C."/>
            </authorList>
            <dbReference type="PubMed" id="17369821"/>
            <dbReference type="DOI" id="10.1038/nchembio869"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INDUCTION</scope>
        <scope>PATHWAY</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2010" name="J. Am. Chem. Soc." volume="132" first="13604" last="13607">
            <title>Analysis of intact and dissected fungal polyketide synthase-nonribosomal peptide synthetase in vitro and in Saccharomyces cerevisiae.</title>
            <authorList>
                <person name="Xu W."/>
                <person name="Cai X."/>
                <person name="Jung M.E."/>
                <person name="Tang Y."/>
            </authorList>
            <dbReference type="PubMed" id="20828130"/>
            <dbReference type="DOI" id="10.1021/ja107084d"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2013" name="Chem. Sci." volume="4" first="3845" last="3856">
            <title>One pathway, many compounds: Heterologous expression of a fungal biosynthetic pathway reveals its intrinsic potential for diversity.</title>
            <authorList>
                <person name="Wasil Z."/>
                <person name="Pahirulzaman K.A.K."/>
                <person name="Butts C."/>
                <person name="Simpson T.J."/>
                <person name="Lazarus C.M."/>
                <person name="Cox R.J."/>
            </authorList>
            <dbReference type="DOI" id="10.1039/c3sc51785c"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2014" name="Org. Lett." volume="16" first="6390" last="6393">
            <title>Methylation-dependent acyl transfer between polyketide synthase and nonribosomal peptide synthetase modules in fungal natural product biosynthesis.</title>
            <authorList>
                <person name="Zou Y."/>
                <person name="Xu W."/>
                <person name="Tsunematsu Y."/>
                <person name="Tang M."/>
                <person name="Watanabe K."/>
                <person name="Tang Y."/>
            </authorList>
            <dbReference type="PubMed" id="25494235"/>
            <dbReference type="DOI" id="10.1021/ol503179v"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="1 2 3 4 8">Acyl-CoA dehydrogenase; part of the gene cluster that mediates the biosynthesis of aspyridones (PubMed:17369821, Ref.5). The polyketide-amino acid backbone preaspyridone A is first assembled by the PKS-NRPS hybrid apdA (PubMed:17369821, PubMed:20828130). The assembly of preaspyridone A is initiated by loading of malonyl-CoA onto apdA, followed by decarboxylation to yield the acetyl starter unit (PubMed:20828130). The growing polyketide chain then elongates into a tetraketide (PubMed:20828130). The adpA PKS module catalyzes three Claisen condensations, as well as beta-keto processing and methylation (PubMed:17369821, PubMed:20828130). Alpha-methylation step during polyketide synthesis is a prerequisite and a key checkpoint for chain transfer between PKS and NRPS modules (PubMed:25494235). The downstream NRPS module contains the condensation (C), adenylation (A), and thiolation (T) domains and catalyzes the incorporation of tyrosine via the formation of the L-tyrosinyl-thioester and the amide linkage between L-tyrosinyl-thioester and the tetraketide (PubMed:20828130). The bimodular assembly line is terminated with a reductase (R) domain that facilitates formation and release of the tetramic acid product (PubMed:20828130). Because apdA lacks a designated enoylreductase (ER) domain, the required activity is provided the enoyl reductase apdC (PubMed:17369821, PubMed:20828130, Ref.5). ApdC appears to operate with different stereoselectivity in different PKS cycle (Ref.5). Combined with apdC, apdA is proposed to synthesize preaspyridone A via about 20 enzymatic steps (PubMed:20828130). A number of oxidative steps performed successively by the cytochrome P450 monooxygenases apdE and apdB are required for the conversion of preaspyridone A to aspyridone A (PubMed:17369821). The cytochrome P450 monooxygenase apdE is responsible for the oxidative dephenylation of preaspyridone A (Ref.5). Finally, the predicted FAD-dependent monooxygenase apdD and the acyl-CoA dehydrogenase apdG may be involved in the transformation of aspyridone A into aspyridone B (Probable) (PubMed:17369821).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="induction">
        <text evidence="1">Expression is positively regulated by the aspyridones cluster specific transcription regulator apdR (PubMed:17369821).</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="7"/>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF80495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AACD01000153">
        <property type="protein sequence ID" value="EAA67037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_681684.1">
        <property type="nucleotide sequence ID" value="XM_676592.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ATG5"/>
    <dbReference type="SMR" id="Q5ATG5"/>
    <dbReference type="STRING" id="227321.Q5ATG5"/>
    <dbReference type="EnsemblFungi" id="CBF80495">
        <property type="protein sequence ID" value="CBF80495"/>
        <property type="gene ID" value="ANIA_08415"/>
    </dbReference>
    <dbReference type="KEGG" id="ani:ANIA_08415"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN8415"/>
    <dbReference type="eggNOG" id="KOG0141">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018204_4_1_1"/>
    <dbReference type="InParanoid" id="Q5ATG5"/>
    <dbReference type="OMA" id="YTTMAVR"/>
    <dbReference type="OrthoDB" id="10254877at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050741">
        <property type="entry name" value="Acyl-CoA_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083:SF15">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE APDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083">
        <property type="entry name" value="MEDIUM-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-0274">FAD</keyword>
    <keyword id="KW-0285">Flavoprotein</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000438456" description="Acyl-CoA dehydrogenase apdG">
        <location>
            <begin position="1"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000269" key="1">
        <source>
            <dbReference type="PubMed" id="17369821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="20828130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="25494235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source ref="5"/>
    </evidence>
    <evidence type="ECO:0000303" key="5">
        <source>
            <dbReference type="PubMed" id="17369821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="6"/>
    <evidence type="ECO:0000305" key="7">
        <source>
            <dbReference type="PubMed" id="17369821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="8">
        <source ref="5"/>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAA67037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005890"/>
        </source>
    </evidence>
    <sequence length="438" mass="47824" checksum="13AC0457AD908F2F" modified="2005-04-26" version="1">MAEISSVPFAEPPYLRGLPSPYYNESHRRFQKACRAFLYENLLKHAMEWEKAGTVPEHVFSDFCKANMLLPNLPAPLPVAWLKRLGIHDILGVKVEEWDYLHTGIYSDEMARSGLSGPSGSLTAGFAFGTPPIIKYGSKELQEKFLPDLLTGKKRNCIAITEPDAGSDVAGITTTATKSADGKYYIVNGNKKWITNGIWSDYSTMAVRTGGPGAGGLSLLVVPLKNYPGVTMQRLKVSGQITGGTTYIELDEVKVPVENLIGLEGDGMKMIMNNFNHERLTIAVGVTRQARVALSTAFSYCLKREAFGKTLMDQPVVRHRLAKAGAELETMWAFVEQLLYQLTNLPKEEADRQLGGITAMAKAKGAMVLNECAQTAVLLFGGAGFTKQGQGELAEAILRDVPGARIPGGSEDVLLDLSIRQLVKLFKAEEKKLGKARI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2016-11-30" modified="2025-04-09" version="130" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ATG9</accession>
    <accession>C8VEB2</accession>
    <name>APDE_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cytochrome P450 monooxygenase apdE</fullName>
            <ecNumber evidence="7">1.-.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Aspyridones biosynthesis protein E</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">apdE</name>
        <name type="ORF">AN8411</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2007" name="Nat. Chem. Biol." volume="3" first="213" last="217">
            <title>Genomics-driven discovery of PKS-NRPS hybrid metabolites from Aspergillus nidulans.</title>
            <authorList>
                <person name="Bergmann S."/>
                <person name="Schuemann J."/>
                <person name="Scherlach K."/>
                <person name="Lange C."/>
                <person name="Brakhage A.A."/>
                <person name="Hertweck C."/>
            </authorList>
            <dbReference type="PubMed" id="17369821"/>
            <dbReference type="DOI" id="10.1038/nchembio869"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INDUCTION</scope>
        <scope>PATHWAY</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2010" name="J. Am. Chem. Soc." volume="132" first="13604" last="13607">
            <title>Analysis of intact and dissected fungal polyketide synthase-nonribosomal peptide synthetase in vitro and in Saccharomyces cerevisiae.</title>
            <authorList>
                <person name="Xu W."/>
                <person name="Cai X."/>
                <person name="Jung M.E."/>
                <person name="Tang Y."/>
            </authorList>
            <dbReference type="PubMed" id="20828130"/>
            <dbReference type="DOI" id="10.1021/ja107084d"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>PATHWAY</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2013" name="Chem. Sci." volume="4" first="3845" last="3856">
            <title>One pathway, many compounds: Heterologous expression of a fungal biosynthetic pathway reveals its intrinsic potential for diversity.</title>
            <authorList>
                <person name="Wasil Z."/>
                <person name="Pahirulzaman K.A.K."/>
                <person name="Butts C."/>
                <person name="Simpson T.J."/>
                <person name="Lazarus C.M."/>
                <person name="Cox R.J."/>
            </authorList>
            <dbReference type="DOI" id="10.1039/c3sc51785c"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>PATHWAY</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2014" name="Org. Lett." volume="16" first="6390" last="6393">
            <title>Methylation-dependent acyl transfer between polyketide synthase and nonribosomal peptide synthetase modules in fungal natural product biosynthesis.</title>
            <authorList>
                <person name="Zou Y."/>
                <person name="Xu W."/>
                <person name="Tsunematsu Y."/>
                <person name="Tang M."/>
                <person name="Watanabe K."/>
                <person name="Tang Y."/>
            </authorList>
            <dbReference type="PubMed" id="25494235"/>
            <dbReference type="DOI" id="10.1021/ol503179v"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="4 5 6 7 10">Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of aspyridones (PubMed:17369821, Ref.5). The polyketide-amino acid backbone preaspyridone A is first assembled by the PKS-NRPS hybrid apdA (PubMed:17369821, PubMed:20828130). The assembly of preaspyridone A is initiated by loading of malonyl-CoA onto apdA, followed by decarboxylation to yield the acetyl starter unit (PubMed:20828130). The growing polyketide chain then elongates into a tetraketide (PubMed:20828130). The adpA PKS module catalyzes three Claisen condensations, as well as beta-keto processing and methylation (PubMed:17369821, PubMed:20828130). Alpha-methylation step during polyketide synthesis is a prerequisite and a key checkpoint for chain transfer between PKS and NRPS modules (PubMed:25494235). The downstream NRPS module contains the condensation (C), adenylation (A), and thiolation (T) domains and catalyzes the incorporation of tyrosine via the formation of the L-tyrosinyl-thioester and the amide linkage between L-tyrosinyl-thioester and the tetraketide (PubMed:20828130). The bimodular assembly line is terminated with a reductase (R) domain that facilitates formation and release of the tetramic acid product (PubMed:20828130). Because apdA lacks a designated enoylreductase (ER) domain, the required activity is provided the enoyl reductase apdC (PubMed:17369821, PubMed:20828130, Ref.5). ApdC appears to operate with different stereoselectivity in different PKS cycle (Ref.5). Combined with apdC, apdA is proposed to synthesize preaspyridone A via about 20 enzymatic steps (PubMed:20828130). A number of oxidative steps performed successively by the cytochrome P450 monooxygenases apdE and apdB are required for the conversion of preaspyridone A to aspyridone A (PubMed:17369821). The cytochrome P450 monooxygenase apdE is responsible for the oxidative dephenylation of preaspyridone A (Ref.5). Finally, the predicted FAD-dependent monooxygenase apdD and the acyl-CoA dehydrogenase apdG may be involved in the transformation of aspyridone A into aspyridone B (Probable) (PubMed:17369821).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 7">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="4">Expression is positively regulated by the aspyridones cluster specific transcription regulator apdR (PubMed:17369821).</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="7"/>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF80485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AACD01000153">
        <property type="protein sequence ID" value="EAA67033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_681680.1">
        <property type="nucleotide sequence ID" value="XM_676588.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ATG9"/>
    <dbReference type="SMR" id="Q5ATG9"/>
    <dbReference type="STRING" id="227321.Q5ATG9"/>
    <dbReference type="GlyCosmos" id="Q5ATG9">
        <property type="glycosylation" value="3 sites, No reported glycans"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CBF80485">
        <property type="protein sequence ID" value="CBF80485"/>
        <property type="gene ID" value="ANIA_08411"/>
    </dbReference>
    <dbReference type="KEGG" id="ani:ANIA_08411"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN8411"/>
    <dbReference type="eggNOG" id="KOG0158">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_27_0_1"/>
    <dbReference type="InParanoid" id="Q5ATG9"/>
    <dbReference type="OMA" id="TDLLWSM"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11063">
        <property type="entry name" value="CYP52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002974">
        <property type="entry name" value="Cyt_P450_E_CYP52_ascomycetes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047146">
        <property type="entry name" value="Cyt_P450_E_CYP52_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287:SF18">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE APDE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01239">
        <property type="entry name" value="EP450IICYP52"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0349">Heme</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0503">Monooxygenase</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000438448" description="Cytochrome P450 monooxygenase apdE">
        <location>
            <begin position="1"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="1">
        <location>
            <position position="466"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="327"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="379"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P04798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="17369821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="20828130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="6">
        <source>
            <dbReference type="PubMed" id="25494235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="7">
        <source ref="5"/>
    </evidence>
    <evidence type="ECO:0000303" key="8">
        <source>
            <dbReference type="PubMed" id="17369821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="9"/>
    <evidence type="ECO:0000305" key="10">
        <source ref="5"/>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAA67033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005890"/>
        </source>
    </evidence>
    <sequence length="519" mass="60440" checksum="B367EE6EB6FFA287" modified="2005-04-26" version="1">MSLASTLPRASFETLLQHTNFMDGIKFVFFAFVVYSCFTIAVGWVVYEWKRKAHGCGKIPRYPHRDPFFGFDIVFGMAKSLRNDYFLVWLNKVHENLPKTFLVNFVGTRFIYTIEPENMKSMSAINWQDFAVGPMRRNNKATAPFADKGVNTVDGHEWEFSRFLIKPFFKRETFTDTSRLTLHVDRVLEQLPADGETVNIQPLIQRWFLDVTTASLFGESIESLVYPERAPICWAMVDVLRGLRLRLQWYKYLWLFRHQAWLDAVEVVHRYLNAHIDRTYKELDEYKRQGKNPEAADRNDLLWYMASNLQDKEALRSQICLIFVPNNDTTSIFISHILWNLARHPGIYEKCRQEVLALGDAELSFSVLRNMKYLNAVLNETHRLFPNGVTQVRKCIRDTTLPVGGGPDGKQPIFVRKGDVVQVNKNVIHRDHDIWGPDAEDFRPERWENLRPYWNFVPFGGGPRRCPAQMLVTAEASYFLARLMRVYKRIEARDPNPYVGVMRVGPSNKTGVHIALFKE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2016-06-08" modified="2026-01-28" version="112" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ATK1</accession>
    <accession>C8VE77</accession>
    <name>AUSB_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">FAD-binding monooxygenase ausB</fullName>
            <ecNumber evidence="6">1.14.13.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Austinoid biosynthesis clusters protein B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ausB</name>
        <name type="ORF">AN8379</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2012" name="ACS Chem. Biol." volume="7" first="599" last="606">
            <title>Signaling the induction of sporulation involves the interaction of two secondary metabolites in Aspergillus nidulans.</title>
            <authorList>
                <person name="Rodriguez-Urra A.B."/>
                <person name="Jimenez C."/>
                <person name="Nieto M.I."/>
                <person name="Rodriguez J."/>
                <person name="Hayashi H."/>
                <person name="Ugalde U."/>
            </authorList>
            <dbReference type="PubMed" id="22234162"/>
            <dbReference type="DOI" id="10.1021/cb200455u"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2012" name="J. Am. Chem. Soc." volume="134" first="4709" last="4720">
            <title>Two separate gene clusters encode the biosynthetic pathway for the meroterpenoids austinol and dehydroaustinol in Aspergillus nidulans.</title>
            <authorList>
                <person name="Lo H.C."/>
                <person name="Entwistle R."/>
                <person name="Guo C.J."/>
                <person name="Ahuja M."/>
                <person name="Szewczyk E."/>
                <person name="Hung J.H."/>
                <person name="Chiang Y.M."/>
                <person name="Oakley B.R."/>
                <person name="Wang C.C."/>
            </authorList>
            <dbReference type="PubMed" id="22329759"/>
            <dbReference type="DOI" id="10.1021/ja209809t"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2013" name="J. Am. Chem. Soc." volume="135" first="10962" last="10965">
            <title>Spiro-ring formation is catalyzed by a multifunctional dioxygenase in austinol biosynthesis.</title>
            <authorList>
                <person name="Matsuda Y."/>
                <person name="Awakawa T."/>
                <person name="Wakimoto T."/>
                <person name="Abe I."/>
            </authorList>
            <dbReference type="PubMed" id="23865690"/>
            <dbReference type="DOI" id="10.1021/ja405518u"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2017" name="ACS Chem. Biol." volume="12" first="2927" last="2933">
            <title>Rewiring of the austinoid biosynthetic pathway in filamentous fungi.</title>
            <authorList>
                <person name="Mattern D.J."/>
                <person name="Valiante V."/>
                <person name="Horn F."/>
                <person name="Petzke L."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="29076725"/>
            <dbReference type="DOI" id="10.1021/acschembio.7b00814"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="4 5 6 7">FAD-binding monooxygenase; part of the gene cluster A that mediates the biosynthesis of austinol and dehydroaustinol, two fungal meroterpenoids (PubMed:22329759). The first step of the pathway is the synthesis of 3,5-dimethylorsellinic acid by the polyketide synthase ausA (PubMed:22329759). 3,5-dimethylorsellinic acid is then prenylated by the polyprenyl transferase ausN (PubMed:22329759). Further epoxidation by the FAD-dependent monooxygenase ausM and cyclization by the probable terpene cyclase ausL lead to the formation of protoaustinoid A (PubMed:22329759). Protoaustinoid A is then oxidized to spiro-lactone preaustinoid A3 by the combined action of the FAD-binding monooxygenases ausB and ausC, and the dioxygenase ausE (PubMed:22329759, PubMed:23865690). Acid-catalyzed keto-rearrangement and ring contraction of the tetraketide portion of preaustinoid A3 by ausJ lead to the formation of preaustinoid A4 (PubMed:22329759). The aldo-keto reductase ausK, with the help of ausH, is involved in the next step by transforming preaustinoid A4 into isoaustinone which is in turn hydroxylated by the P450 monooxygenase ausI to form austinolide (PubMed:22329759). Finally, the cytochrome P450 monooxygenase ausG modifies austinolide to austinol (PubMed:22329759). Austinol can be further modified to dehydroaustinol which forms a diffusible complex with diorcinol that initiates conidiation (PubMed:22234162, PubMed:22329759). Due to genetic rearrangements of the clusters and the subsequent loss of some enzymes, the end products of the Emericella nidulans austinoid biosynthesis clusters are austinol and dehydroaustinol, even if additional enzymes, such as the O-acetyltransferase ausQ and the cytochrome P450 monooxygenase ausR are still functional (PubMed:29076725).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>protoaustinoid A + AH2 + O2 = berkeleyone A + A + H2O</text>
            <dbReference type="Rhea" id="RHEA:65140"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:69024"/>
            <dbReference type="ChEBI" id="CHEBI:156350"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:65141"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="1">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Secondary metabolite biosynthesis; terpenoid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="5">Impairs the synthesis of austinol and dehydroaustinol and accumulates the intermediate compound protoaustinoid A (PubMed:22329759).</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="10">In A.calidoustus, the austinoid gene cluster lies on a contiguous DNA region, while clusters from E.nidulans and P.brasilianum are split in their respective genomes. Genetic rearrangements provoked variability among the clusters and E.nidulans produces the least number of austionoid derivatives with the end products austinol and dehydroaustinol, while P.brasilianum can produce until acetoxydehydroaustin, and A.calidoustus produces the highest number of identified derivatives.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.-" evidence="6"/>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF80421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AACD01000152">
        <property type="protein sequence ID" value="EAA66899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_681648.1">
        <property type="nucleotide sequence ID" value="XM_676556.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ATK1"/>
    <dbReference type="SMR" id="Q5ATK1"/>
    <dbReference type="STRING" id="227321.Q5ATK1"/>
    <dbReference type="GlyCosmos" id="Q5ATK1">
        <property type="glycosylation" value="3 sites, No reported glycans"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CBF80421">
        <property type="protein sequence ID" value="CBF80421"/>
        <property type="gene ID" value="ANIA_08379"/>
    </dbReference>
    <dbReference type="KEGG" id="ani:ANIA_08379"/>
    <dbReference type="eggNOG" id="ENOG502SHCE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006937_8_2_1"/>
    <dbReference type="InParanoid" id="Q5ATK1"/>
    <dbReference type="OMA" id="TANQSYM"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="UniPathway" id="UPA00213"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900563">
        <property type="term" value="P:dehydroaustinol biosynthetic process"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050775">
        <property type="entry name" value="FAD-binding_Monooxygenases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43098:SF2">
        <property type="entry name" value="FAD-BINDING MONOOXYGENASE AUSB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43098">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0274">FAD</keyword>
    <keyword id="KW-0285">Flavoprotein</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0503">Monooxygenase</keyword>
    <keyword id="KW-0521">NADP</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000436483" description="FAD-binding monooxygenase ausB">
        <location>
            <begin position="1"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="212"/>
            <end position="215"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="222"/>
            <end position="224"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="224"/>
            <end position="225"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="375"/>
            <end position="381"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="398"/>
            <end position="399"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="1">
        <location>
            <position position="517"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="627"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="645"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="H3JQW0"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="22234162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="22329759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="6">
        <source>
            <dbReference type="PubMed" id="23865690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="7">
        <source>
            <dbReference type="PubMed" id="29076725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="8">
        <source>
            <dbReference type="PubMed" id="22329759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="9"/>
    <evidence type="ECO:0000305" key="10">
        <source>
            <dbReference type="PubMed" id="29076725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAA66899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000005890"/>
        </source>
    </evidence>
    <sequence length="745" mass="82277" checksum="2A8BE15B0AF21073" modified="2005-04-26" version="1">MAKLYYMPYIFNEGMPLASGPPTLPEDFTPEKSGFRVLVEVRRMKGHFPAQKWRKRNQEWQCINNETLLPDHVRNGHLAKNVPYRPYRPVYVPFAMTVSPTTDAMGTSEETRSKQTKGSNDDILSAKIAGRVARPVYHCTSARLHDLAYDPWPITTIDTHGLSSLKAPSTHTRILIIGAGFGGLLFAVRLLQAGFSRDDLLLVDSAGGFGGTWYWNRYPGLMCDIESYIYMPLLEETGHMPSRKYVPGEELRTHAEGIAAKWELEQRALFRTTIRTLEWDEGGNQWIAHAEQLGVFTDAKQGGNGGGGPLTFTATFAIIASGTLSKPKVPNLHGVDDFQGHIFHTARWDYDYTGGSPANPAMHRLQGKRVGVIGTGSTAVQVIPQLARWSKELIVFQRTPAAVGLQKNQVTDPVWWKGNILKAGSGWQRKRSENFNAFISISNPPCMENLVNDGWTSSPSFSAAIGGALNMQPDFLDLVKAIDRPRLEAAQDHIRSTVRDDTTAEALINLNHGWCKRPCFHQGYFETYNLPHVRLIKTDAAGVTGLSPKGILVGDTLYEVDLVVLATGYDLGSLCPADRAQIQVLGSEGVAMKEKWAGGPTTLHGVMTRGFPNLFFPGTSQAGVTANQSYMFDRAAEHVAYIIQNSTLEAGGYIDKIRIEPTAEGEKHWTTQSVARISAFAATTACGTGDYTISNRYRSSDVDTMARHMPWGEGMASYVKILEAWRESGTMEGLDIRYHSSEGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AU38</accession>
    <accession>C8V753</accession>
    <name>Q5AU38_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ulp1 protease family protein (AFU_orthologue AFUA_5G03200)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ANIA_08192</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C48 family.</text>
    </comment>
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        <property type="protein sequence ID" value="CBF74074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_676369.1"/>
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    <dbReference type="AlphaFoldDB" id="Q5AU38"/>
    <dbReference type="STRING" id="227321.Q5AU38"/>
    <dbReference type="GeneID" id="2869197"/>
    <dbReference type="KEGG" id="ani:ANIA_08192"/>
    <dbReference type="eggNOG" id="KOG0779">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_007167_1_0_1"/>
    <dbReference type="InParanoid" id="Q5AU38"/>
    <dbReference type="OMA" id="REYLCKE"/>
    <dbReference type="OrthoDB" id="442460at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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    <dbReference type="GO" id="GO:0016929">
        <property type="term" value="F:deSUMOylase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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    <dbReference type="GO" id="GO:0016926">
        <property type="term" value="P:protein desumoylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051947">
        <property type="entry name" value="Sentrin-specific_protease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46896:SF3">
        <property type="entry name" value="FI06413P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46896">
        <property type="entry name" value="SENTRIN-SPECIFIC PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02902">
        <property type="entry name" value="Peptidase_C48"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50600">
        <property type="entry name" value="ULP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="3 8" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-like protease family profile" evidence="7">
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            <begin position="519"/>
            <end position="819"/>
        </location>
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="6">
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            <end position="185"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="6">
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="6">
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="6">
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    <feature type="region of interest" description="Disordered" evidence="6">
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            <begin position="890"/>
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        </location>
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            <begin position="984"/>
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        <location>
            <begin position="1"/>
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        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBF74074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="1051" mass="116852" checksum="933DC3ACF4C7F00E" modified="2005-04-26" version="1">MPSPVRDRGPMRETPSSSIADEYRLFGGGKQRDPNAVRVVPGQTFALKPWNTISRGAKGSGTVSANRKEKRFYTSHSRSDHPADAPERSSKRRRVEGPAEAQAAINISDDETPAHSSTRGSPVTTRSHAKSPTPSFSSNTRQPREYNSGLTSEYRTIDKGARVPRPSPKKKASSADPFSSEDPDIIFTRDAAKVRRKESALLQGDPDNVPWKAPAHASNLSVEIVNKPSVSDGAFKTPPPRHEKPRALSSRDSPDELQGDVTVGPVPTSLSKPRRESRDEPLSSDIRPTLFTSQVMSRLGKTRNKRGRASKGLPQRQTFRLVYYRGGSFLQEVPKGENDQLIMDPGGGDSGRQKKRSSFALVYANSRLRFRKRQESPKEAPKPPPGSTTKRMRLSDALQVTDEEAAAPRSSDTASGSRTSPSLPTTTGENTISKRAPSPTSRLHRDIGIEIPMKKFQSNSQAPTRTTRSRLMSRQTPTTLVCDDDDNENEEEYTPQPNLGGEQKWDRPLVYPRFGKKKAEVNALDLRRLAPHEFLNDNIIGFYIRFLEDHLQRCRPEAAQRVYFFNSYFFATLTKSPKGLKINYEGVAKWTRNVDIFSYDYIVVPINENAHWYMAIICNLPYLEGIGEEEKPLPSESRAEVEEVPETPEPHLEDGSSTTLQSIKEETARQSLASMSLIDTQVPQEEASKPGENEWSERDVYPDAARAKLAAPSSQPQPETQKDSEASGTPKKSRKPKKNRSYGVKYSTCQPIIITFDSLDLPRSGTISILREYLFAEAKSKRGIEIDKSLVKGMTAKEIPHQPNFSDCGLYLLAYAEKFVQDPDSFVRKLLRKEMRKQEDWPPLKSGLLRTRLRGFMELLYTEQEHLTKAKADESALVVDQQPVSYLLGDTAANNKDNVEGENYPQGKVQVERSPPAEASSKTTPERQPFAQSASPKPEIGHDVDPVNVDTQESVLCISQIPDAQLKSQKLEAYNQPSKHVVVEVPDSQDRTQANGPTAAALSTETPSSKPHPRREHSSAVYVDDSDDVEDAPQQGGVQVEETPPGLPSIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AUQ8</accession>
    <accession>C8V5E9</accession>
    <name>Q5AUQ8_EMENI</name>
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        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ANIA_07972</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF73623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_681241.1">
        <property type="nucleotide sequence ID" value="XM_676149.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AUQ8"/>
    <dbReference type="GeneID" id="2869317"/>
    <dbReference type="KEGG" id="ani:ANIA_07972"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_1_1_1"/>
    <dbReference type="InParanoid" id="Q5AUQ8"/>
    <dbReference type="OMA" id="AHYHTHW"/>
    <dbReference type="OrthoDB" id="5296287at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000082">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF135">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="97"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="286"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="331"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="371"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="395"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="428"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="60"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="10"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBF73623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="454" mass="49027" checksum="DC55961EA233911E" modified="2005-04-26" version="1">MAVDLELAYEKPAISGDGHDQQSSEPDQTAFEQETKDNVVDWDGPGDPHNPRNWPAWRRMSQVVLASGFLLTANLAATMFAPGAASLAKEFHITSSTIVSLTVSIYLCGFAVGPMFIAPLSELYGRLVIYHACNVIYIGFLIGCALAKNTGMFLVFRFLAGCASSGPLTVGGGTVADVVPPAQRGRAMSLFSTGPLLGPVLGPIIGGFVSELIGWRWTFWIITVLAGVLFIISIFFLRETNAAVLLEWKAARLRKETGNTALVSKMDRGLTPRQLFVRAITRPTKFLLLSPIVLLLSLLCAFVFGLLFMLFTTFPTVFEEQYNFSAGISGLSYLGVGIGMAVSLGVFAAVSDKLQKALGDSPKPEGRLKPMAWVMPAVPVGIFWYGWAAEKQTHWIVPIIGTSFFGFGLLWIIMPTQLYMVDAFGPEAAASALAANVILRLLFAAFVPLAGPPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AUR3</accession>
    <accession>C8V5E4</accession>
    <name>Q5AUR3_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Nucleoside transporter, putative (AFU_orthologue AFUA_2G04690)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ANIA_07967</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF73614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_681236.1">
        <property type="nucleotide sequence ID" value="XM_676144.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AUR3"/>
    <dbReference type="GeneID" id="2869271"/>
    <dbReference type="KEGG" id="ani:ANIA_07967"/>
    <dbReference type="eggNOG" id="ENOG502QR29">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026016_2_1_1"/>
    <dbReference type="InParanoid" id="Q5AUR3"/>
    <dbReference type="OMA" id="YWCTSYA"/>
    <dbReference type="OrthoDB" id="5428495at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015851">
        <property type="term" value="P:nucleobase transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.4160.10:FF:000002">
        <property type="entry name" value="Purine-cytosine permease fcyB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026030">
        <property type="entry name" value="Pur-cyt_permease_Fcy2/21/22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806">
        <property type="entry name" value="PURINE-CYTOSINE PERMEASE FCY2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806:SF7">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G04690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002744">
        <property type="entry name" value="Pur-cyt_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="162"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="295"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="352"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="388"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="417"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="458"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR002744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBF73614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="551" mass="59926" checksum="D8F85B10C33448EA" modified="2005-04-26" version="1">MVSDSDPEKGVHAVSCAAENGIPQVSSNGAPGLETTQLFDDASGGGVLCWLNGLEARMDRKLGVESEAIDRKRAEDKKPVSWFEELTMALLWASGVMNTSCFATGFLGWEFGLSLKQSMLIVIFASILGGALTGFCATFGGATGLRQISVSRYSFGWWPNKLIALLNGIQQMGWAAVSCITGGLALTAVSDGHVSLILGIVILAVVALFISFVGLNAILVYERYAWMIFFIIFMIIYGDTGRYADNESPASAEGLTLSGSLLSLLAVVYGSSASWCTMASDYYVHYPANVNRVKVFFMTTLGIALPTCIPMIAGCVVASAFKNKQEWQSAYEDQGLGYLIQDMLHPRGFAKFLLTLLVLSGINQNVISIYSASISFQQLARPFGRIPRFLWTLFCFACILALAVGGRAKLNEYLQNFLSLLGYWCTSYAIILFQEHFIFRKGSFENYDLEGWNDPARLPVGIAAAVAFCLGIIAWCMGMDETWFIGPLAKVIGESGGDVANELTFVVTAVTYAPASLNPEPHKFCISLDSRSDLTTTRFLCPCHHEHPVTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AV27</accession>
    <accession>C8V3L4</accession>
    <name>Q5AV27_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ANIA_07853</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF73388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_681122.1">
        <property type="nucleotide sequence ID" value="XM_676030.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AV27"/>
    <dbReference type="GeneID" id="2869263"/>
    <dbReference type="KEGG" id="ani:ANIA_07853"/>
    <dbReference type="HOGENOM" id="CLU_2038047_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AV27"/>
    <dbReference type="OrthoDB" id="2094269at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF73388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="121" mass="13027" checksum="749119569CAEFE42" modified="2005-04-26" version="1">MGNPNCCSVAASLILDHQNEQPQCPLPFCALIFICGGLPLPILASWGLPISAAAWEVHERTAHELWEQAGAVESILTACQARLDAVQAWPTANRLFADPESKNLCTPAAIDPHNVFRLGLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="115" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AWB2</accession>
    <accession>C8VCC2</accession>
    <name>Q5AWB2_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Phenol 2-monooxygenase, putative (AFU_orthologue AFUA_1G13660)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ANIA_07418</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PheA/TfdB FAD monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF78415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_680687.1">
        <property type="nucleotide sequence ID" value="XM_675595.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AWB2"/>
    <dbReference type="GeneID" id="2869810"/>
    <dbReference type="KEGG" id="ani:ANIA_07418"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN7418"/>
    <dbReference type="eggNOG" id="KOG3855">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009665_9_2_1"/>
    <dbReference type="InParanoid" id="Q5AWB2"/>
    <dbReference type="OMA" id="DYWKVFV"/>
    <dbReference type="OrthoDB" id="1716816at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02979">
        <property type="entry name" value="PHOX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012941">
        <property type="entry name" value="Phe_hydrox_C_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038220">
        <property type="entry name" value="PHOX_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050641">
        <property type="entry name" value="RIFMO-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004:SF20">
        <property type="entry name" value="2-MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G13660)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004">
        <property type="entry name" value="TRK SYSTEM POTASSIUM UPTAKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07976">
        <property type="entry name" value="Phe_hydrox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="12"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="Phenol hydroxylase-like C-terminal dimerisation" evidence="6">
        <location>
            <begin position="467"/>
            <end position="675"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBF78415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="694" mass="78492" checksum="0B2124B99C8A2883" modified="2005-04-26" version="1">MPGTVPTHEDHVDVLIVGAGPAGLMLSTWLSRCGIKTRIVDKRGTKVFNGQADGLQCRTLEIFDSFGFAHRAWRESNHMIEICLWNPDENGRIRRSDRIPDTIPQISRFQQVVLHQGRIERFFLDSMKEHSNLTVERGVLPVSFEIDEAKAADFDDYPISVTLRTLSDKEATPQQRQQHQKSADGQRAVVDDGLFRSNLVADDTDDLIRAATADSSRDGQVELVKAKFLVGCDGAHSWVRRQAGFKLEGDSTDYIWGVLDIVPITDFPDIRHRCAIHSANAGTIMVIPRENKLVRLYIQLQATSYNKNGEKADRSWITPDIILQSAQRIIHPYKLDYSYCDWWTAYQIGQRVGDHFSLHDRVFLAGDAVHTHSPKAGQGMNVSMQDTYNLGWKLAHVVKGYCDPAILKTYESERRGIAQQLIAFDHRFSRLFSGRPARDIIDEEGVSMEEFKATFEKGNEFASGIAVNYDASLLVAKGSKIAESNDEYKCRVTSKPQLATKIDVGKRMPSFKVLNQADARPWHLQELLKSNGRWRVIVFPGRLTDPRNMQRFQQLGQKLGDPDSFIRQYTPPGQPIDSMIEVLTVHAGPRTEIELLDLPEAFHPNHGDMGWDYWKVYVDDDSYHEGHGQAYANYGIDPSNGASVIIRPDQYVSWVGDMDDYEEMARFFSAFMKQQVAGKPGAANVRVPFMTTKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="115" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AWH1</accession>
    <accession>C8VCJ1</accession>
    <name>Q5AWH1_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Cytochrome P450, putative (Eurofung)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">ANIA_07359</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF78548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_680628.1">
        <property type="nucleotide sequence ID" value="XM_675536.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AWH1"/>
    <dbReference type="GeneID" id="2869794"/>
    <dbReference type="KEGG" id="ani:ANIA_07359"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN7359"/>
    <dbReference type="eggNOG" id="KOG0157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_14_0_1"/>
    <dbReference type="InParanoid" id="Q5AWH1"/>
    <dbReference type="OMA" id="MWLQYYA"/>
    <dbReference type="OrthoDB" id="3934656at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11060">
        <property type="entry name" value="CYP57A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000050">
        <property type="entry name" value="Cytochrome P450 monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF232">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 10" id="KW-0349">Heme</keyword>
    <keyword evidence="7 9 10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="461"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CBF78548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="514" mass="57699" checksum="6431AC6F4A15D2B1" modified="2005-04-26" version="1">MPTTLSTLQSSLPLPLPVLAIIALFLLRFIWRRFGSGLRGIPGPALAKCTRLWKLHSVWKGDHHLTEINLHRQHGPLVRIGPRHVSVADPKAIPVIYGLNKGFTKTGFYPIQCISWNKKPQMNLFSTRDEQFHRDQKRPVANAYSMTSLLELEPAVDSCTAIFLSRLRDFAGKKRPVDLGTWLQYYAFDVVGEFTFAKKLGFLEEGRDVDDMMAGIQGILAYASLIGQVPEAHKVLLGNPLMPILMPSMESWNQVLQFTLKQVNSRTSLARDGELDKGDLEEGKDMLSRWMAIHVADPEKMSTRDVIVHLSTNVFAGSDTTAIALRAIMYFLLKNPDKMEKAVGEIEAADSAGRLSSPISYKESMTHLPYLGAAIKEAMRLHPSVGLILERHVPEGGVTVCGRYIPAGTTVGINAWALHHDEKVFPSPGAFMPERWLESPPAKLKEMEQSFFAFGAGSRTCVGKNISLIEMHKIIPQLLRDFTFRLHRPGDEWKTKNAWFVQQEGLVVDLERRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AXH9</accession>
    <accession>C8VC97</accession>
    <name>Q5AXH9_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Oxidoreductase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_07001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF79283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_664605.1">
        <property type="nucleotide sequence ID" value="XM_659513.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AXH9"/>
    <dbReference type="STRING" id="227321.Q5AXH9"/>
    <dbReference type="GeneID" id="2869987"/>
    <dbReference type="KEGG" id="ani:ANIA_07001"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN7001"/>
    <dbReference type="eggNOG" id="KOG4690">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062297_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AXH9"/>
    <dbReference type="OMA" id="VNCVWDM"/>
    <dbReference type="OrthoDB" id="10064411at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019180">
        <property type="entry name" value="Oxidoreductase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039251">
        <property type="entry name" value="OXLD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21193">
        <property type="entry name" value="OXIDOREDUCTASE-LIKE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21193:SF3">
        <property type="entry name" value="OXIDOREDUCTASE-LIKE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09791">
        <property type="entry name" value="Oxidored-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidoreductase-like" evidence="2">
        <location>
            <begin position="137"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF79283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="258" mass="28450" checksum="668C02BEADBB20A2" modified="2005-04-26" version="1">MEDHALFTIRHLLLRSFRASPFPSIRTSLAQNSRHRRISSPKRLLHHHAKHTNHLGDGQAYPLSGYYSDILSARHSHRGQATTSPSAPQQKPETPRAQTNQLPQSPEERMAIVFGTRLAGPGRSSRYNRGSNSAWKTVNGVPIPPRPEEPDNCCMSGCVHCVWDDYRDEMEEWAALLAQAKAKGGTSKSPKVVPTAIPKTPVDVAASTSMDDDGGGSETNWSLPGSGDDLFADIPVGIREFMKTEKRLKQLHRNADDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AYA6</accession>
    <accession>C8V1W3</accession>
    <name>Q5AYA6_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_06724</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF71333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_664328.1">
        <property type="nucleotide sequence ID" value="XM_659236.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AYA6"/>
    <dbReference type="STRING" id="227321.Q5AYA6"/>
    <dbReference type="GeneID" id="2870353"/>
    <dbReference type="KEGG" id="ani:ANIA_06724"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN6724"/>
    <dbReference type="HOGENOM" id="CLU_320042_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AYA6"/>
    <dbReference type="OrthoDB" id="4497052at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="552"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="598"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="651"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="598"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="687"/>
            <end position="707"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF71333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="907" mass="102608" checksum="A2094D08CBB908F6" modified="2005-04-26" version="1">MSYFSRHGSGGAASAYPTLPPTPEEPEEDILTDHENEETGLCHHQPYAKNAVEAPDQYRHATVESHAQSSDDLQNEVVTTSTKCSNANEADTVLPLRPRSRSSTISTEPFPDLDASMSELPSLAYRAQEEAYKHAMGKVAEEILRMNEIRDHIIAIRGPASSVEDEELARSRSSMIVLEGVRPCPEVSHHDHFCVQQEAHKRAMHERVDQFLKGREDVPKHFGKRFSAVTSMIVHMEFILFRSKNFPRDPLNQASENDLKTVFHYTTKIIEYFSAVGGLIFRERNNAERARVLISQVAAKTGVTLLDRFKEMAAIIIQYLKRARRSEQNFFEIFQQFFEVWLYDDFHVMYNNYLVEHMPNIPPNFQRLSYLLNATYNMLGQMIRDYEALGKINRDIGDRFIRPVVDQMARGDNLYGNPINEPAYPACEHENKYLLALSRSAAERHQSEVHRELAFILGHAQTETGAKHHVNQARSPTVLSACFGISNDEAPQDHAHGLGNRTSQECRAAHEALHYPFHSRVEPHGRRISDRLGPSDVPLVYRSSPFIVRHHSNTLEQGTLSRPYPMPDGYRHDNSQLPEQSILQSSYTSAQMFSSQSSHALAAGSSRSDSLPVEHGKDDTCGVSDTDYAPPEAMTSLKFNRCWEETHRPNSKASLSSYAGHPQTGDAENNGGHITRHGTLNEHLRGHTSTEQSEATSSHSAQSSRTQSYDESKPQCQQDDCPDEDILDLNAAEEEEDEEAWLRHDYIDYRHRCTNTFAARLEALAHIRRQNSIENGEYEDPSNNVPSFAASRPRPSGYSISRSMLQFQYPAYEDASDQDQALERRVVARDDNNSPILPPMPEHPRFAVSLDSDEDHPVPVGIVRPQPRPAAMPIALPCPVTRRGLSSDCEREREVFIYEAPRQNPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AYZ6</accession>
    <accession>C8V039</accession>
    <name>Q5AYZ6_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TauD/TfdA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ANIA_06484</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF69362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_664088.1">
        <property type="nucleotide sequence ID" value="XM_658996.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AYZ6"/>
    <dbReference type="GeneID" id="2871383"/>
    <dbReference type="KEGG" id="ani:ANIA_06484"/>
    <dbReference type="eggNOG" id="ENOG502QS4K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036005_1_0_1"/>
    <dbReference type="InParanoid" id="Q5AYZ6"/>
    <dbReference type="OMA" id="GWHADTS"/>
    <dbReference type="OrthoDB" id="10257314at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051323">
        <property type="entry name" value="AtsK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468:SF20">
        <property type="entry name" value="TAUD_TFDA-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="7">
        <location>
            <begin position="28"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBF69362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="305" mass="34488" checksum="1B60A5AE66DF56B1" modified="2005-04-26" version="1">MADYNPTPSYPQPQRLTGALSQFKYIESTPALGREYMDLQLSSILENDEMVRDLAITASERGVLLFNDQNITPFELKRLLVKLGKLTGNPPEAGLHRSAFPSQIHSHLDIPEVEDPDIFIISSVTQKKSLADALPTGGRKFASWGWHTDESYEKYPPAYTGFKIAKSPPTGGDTLFVSSYGLYEHLSEPWQKFADGLTATHSAKEFLRFMEKGMTLDGELQRGHPENVGLEFRASQYASPLALYTNCSFNPADMRTVLRMITDSSDLQTRKRWNDNGVAIWDKLRYWREALLRPEFCLQGRVSSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="101" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AZ75</accession>
    <accession>C8V0N1</accession>
    <name>Q5AZ75_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">N,O-diacetylmuramidase</fullName>
            <ecNumber evidence="4">3.2.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Lysozyme CH</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">ANIA_06405</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="16">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">This enzyme has both lysozyme (acetylmuramidase) and diacetylmuramidase activities.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 25 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.17" evidence="4"/>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF69534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_664009.1">
        <property type="nucleotide sequence ID" value="XM_658917.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AZ75"/>
    <dbReference type="STRING" id="227321.Q5AZ75"/>
    <dbReference type="CAZy" id="GH25">
        <property type="family name" value="Glycoside Hydrolase Family 25"/>
    </dbReference>
    <dbReference type="GeneID" id="2871301"/>
    <dbReference type="KEGG" id="ani:ANIA_06405"/>
    <dbReference type="eggNOG" id="ENOG502S19Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044973_4_0_1"/>
    <dbReference type="InParanoid" id="Q5AZ75"/>
    <dbReference type="OMA" id="HLPVNWK"/>
    <dbReference type="OrthoDB" id="6590422at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003796">
        <property type="term" value="F:lysozyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016998">
        <property type="term" value="P:cell wall macromolecule catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042742">
        <property type="term" value="P:defense response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031640">
        <property type="term" value="P:killing of cells of another organism"/>
        <property type="evidence" value="ECO:0007669"/>
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        <property type="entry name" value="GLYCOSYL_HYDROL_F25_2"/>
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</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="129" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B010</accession>
    <accession>C8V2D8</accession>
    <name>Q5B010_EMENI</name>
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        <submittedName>
            <fullName evidence="4">Guanyl-nucleotide exchange factor, putative (AFU_orthologue AFUA_2G08780)</fullName>
        </submittedName>
    </protein>
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        <name evidence="4" type="ORF">ANIA_06120</name>
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        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
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            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
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    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
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            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
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        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
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    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBF70145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="1359" mass="149107" checksum="8DFC1A6C5FF85B0D" modified="2005-04-26" version="1">MHWKGLRLGALYDSESKRNPADPQSRHSEQLARSTLSATNLPPRISESSACSPNLTGLDADGQAESEGSNRAPAPGNSSLKSRVPNALNSSREALNRSGSRFSLMRLRHASDPQLSKSYAKAGTEVPPVPNIPPPTIITTAPTSHELDQPVKRKNKFSIFPEPRKSMEAHAEQQTVRNEKAKRSQDSTGSQSADTSLTASRVSAEEPGRLSTTSIRSTGRDRPNGSYRSSVVDGRFSESSRSDQSAATNNEISRTNSPLGGPASGTKRFRMPRLKRNRVQFPLPPKPTADNGQTPGLTQSRSVPDGPTRGSDASDGQDHVSPLPSPSRSSAGLSASRPPIIRKDSSNSAHSVHSTPSIRGGRNQGLPKNRARSSTLDSVTNIQDTDPHPSPNQPSSSRTSFSTTGRKSFGDIFSISQRLRQNSEPGYFRTNSSPSGTKGTSSPLTKVLSYPKREEGDTPATYLARLEENIPKSAVAGVLSQSGEDFYKTALRKFMRGFSFFGDPIDMAIRKLLMEVELPKETQQIDRFLQSFADRYHECNPGIFASTDQAYFIAFSILILHTDVFNKNNKRKMQKGDYVKNTRGEGVAEDILECFYENISYTPFIRIEDSNLGTRHLPKPKKALFRVPSAENLSRATREPVDPYALIMDGKLDTLRPSLRDVMNLEDPYCCNPTTGPADIKSLHRAFAQSAILQIVSARSRPDAFMPASMENPADSNPGLVDIKVAKVGLLWRKDPKKKRARSPWQEWGALLTLSHLYFFKDVNWVKSLMAQCDAHQKEGRRRAVVFKPPLNDFNPVSMMSTDNAVALLDSSYKKHKHAFLFVRPNSLEEVFLANSEADMNDWLAKLNYAAAFRTTGVGTKGMVVTKYDAQRNRMSRRLSFQSEMSRFSSDKEPASPSSGMGAAEELMAARTRLIQQKVREANETLFISQKQLDDILRNARHLQVLTPVHTRAREQLIMAAGRMSAKLKWVRQDIWRTKSHREVLVRDLGEENDQAVTAPEPQRLRLEIPASNSLSGNGGDSVWDKQLSPMFAKSPSIAPEKPSSVNQISSPSSSTGGVRRPSLATSVTSPDILLRTGRPPSVDNYERAKSVSPNPSHVLEREASVLSSGSKMDVSSLASKTSKLTLPGSFDDGEERLLREAGLLDASSASRKGSVTADGMDFDLKKDDAPEGSQDRMSRVRHSFHRTLRDSSSGHHYPRSRKRESAPSVTAAEDSQGSGDAGGLSRKGGSFTVHGKKASIVTFGSDWQNMPPEERLKLRKPTPSEEPRASDTDLVSGGESTRSGLRASLDIPVRLSEEKAEDKLDRRSVRSESAVSTVSQEPSSPSTNVHNSLRSVPLPDSSTVDENPTPTLPQAIHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="104" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B035</accession>
    <accession>C8V2L1</accession>
    <name>Q5B035_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Carboxylic acid transport protein (AFU_orthologue AFUA_2G09450)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ANIA_06095</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF70194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_663699.1">
        <property type="nucleotide sequence ID" value="XM_658607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B035"/>
    <dbReference type="GeneID" id="2870925"/>
    <dbReference type="KEGG" id="ani:ANIA_06095"/>
    <dbReference type="eggNOG" id="ENOG502QPK1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_46_1_1"/>
    <dbReference type="InParanoid" id="Q5B035"/>
    <dbReference type="OMA" id="MIPAWIL"/>
    <dbReference type="OrthoDB" id="5296287at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046943">
        <property type="term" value="F:carboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046942">
        <property type="term" value="P:carboxylic acid transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd17316">
        <property type="entry name" value="MFS_SV2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000395">
        <property type="entry name" value="Carboxylic acid transporter protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000465">
        <property type="entry name" value="Carboxylic acid transporter protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508:SF9">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORT PROTEIN (AFU_ORTHOLOGUE AFUA_2G09450)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="206"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="230"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="282"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="320"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="351"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="447"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="69"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="489"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBF70194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="514" mass="56422" checksum="666544CBCD84A2D1" modified="2005-04-26" version="1">MPSQNEPAEPIPDGIFAVAKQSWGDLFRWKQRVIIENEQGESYAEWQDPEPFKNPISLLMLLSARDWLFFLVGLAAWTADAFDFHALSIQQVKLADYYGKTKTDISTAITLTLLLRSVGAAFFGLAGDRFGRKWPMVINMIVLGVLQIATIYSSTFQQFLAVRSLFGLFMGGVYGNAIAMALEHCPLIARSVSARGLMSGILQQGYSLGYVFAACANLGVGGGTETYKTVFWIAAGISIGIGLIRVLFPESKQFLEAKAAGKRSVSAGEFWRETKVMVGQEWKICVYCIFLMTWFNYYSHTSQDSYTTFMLTQKELENSGASRASILMKTGACVGGTIIGYLSQFVGRRRAIIISAFVSGLIIPAWILPTTERSLSATGFFMQFFVQGAWGVIPIHLNELSPPAFRSLFPGLTYQLGNMISSPSAQIINAIAEKTFIKGPSGNPVEAYGPTMGVATAIIATGIMVTTAFGPEKRGRRFETVVVGMQEQNRTDKQLDLEADSKPGEETVERVDKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B194</accession>
    <accession>C8VFQ7</accession>
    <name>Q5B194_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tropomyosin TpmA (Eurofung)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_05686</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF81405.1"/>
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        <property type="nucleotide sequence ID" value="XM_658198.2"/>
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    <dbReference type="HOGENOM" id="CLU_104738_0_1_1"/>
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    <dbReference type="OrthoDB" id="128924at2759"/>
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        <property type="component" value="Chromosome V"/>
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        <property type="term" value="C:actomyosin contractile ring"/>
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        <property type="term" value="C:formin-nucleated actin cable"/>
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        <property type="term" value="C:mitotic actomyosin contractile ring"/>
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        <property type="term" value="P:mitotic actomyosin contractile ring contraction"/>
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        <property type="term" value="P:mitotic cytokinesis"/>
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    <dbReference type="GO" id="GO:0032220">
        <property type="term" value="P:plasma membrane fusion involved in cytogamy"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000114">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.340:FF:000001">
        <property type="entry name" value="Tropomyosin alpha-1 chain isoform 2"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000533">
        <property type="entry name" value="Tropomyosin"/>
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        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="58"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="58"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="73"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="98"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF81405.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="161" mass="18793" checksum="C7FB594F69EC573E" modified="2005-04-26" version="1">MDRIKEKMNALRLEADEAHEKNEELKARVKTLEQENLAKEQEITSLTHRNQLLEAEVEKLESSAKEAKDAASQSAQHDTQNEALQRRIQLLEEEAEEADRNLRETNEKLRQTDVKAGHYERKVQALETSRDEWERKYEEMAAKHESLKKELAELELSLNSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B1H4</accession>
    <accession>C8VFZ6</accession>
    <name>Q5B1H4_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">V-type proton ATPase subunit a</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ANIA_05606</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the V-ATPase 116 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF81569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_663210.1">
        <property type="nucleotide sequence ID" value="XM_658118.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B1H4"/>
    <dbReference type="FunCoup" id="Q5B1H4">
        <property type="interactions" value="392"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5B1H4"/>
    <dbReference type="GeneID" id="2871898"/>
    <dbReference type="KEGG" id="ani:ANIA_05606"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN5606"/>
    <dbReference type="eggNOG" id="KOG2189">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005230_0_2_1"/>
    <dbReference type="InParanoid" id="Q5B1H4"/>
    <dbReference type="OMA" id="FYLWFFL"/>
    <dbReference type="OrthoDB" id="10264220at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016471">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000220">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051117">
        <property type="term" value="F:ATPase binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002490">
        <property type="entry name" value="V-ATPase_116kDa_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026028">
        <property type="entry name" value="V-type_ATPase_116kDa_su_euka"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11629:SF63">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11629">
        <property type="entry name" value="VACUOLAR PROTON ATPASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01496">
        <property type="entry name" value="V_ATPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001293">
        <property type="entry name" value="ATP6V0A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 9" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="426"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="463"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="550"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="580"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="643"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="785"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="100"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CBF81569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="852" mass="97292" checksum="B55EAA51BB63203B" modified="2005-04-26" version="1">MAPKDTFFRSSDMSLTQLYIANEIGREVVSALGELGQVQFRDLNPETNAFQKTFTKEIRRLDNVERQLRYFHAQMDKAGIQMRPSSEFSDTLAAPLASEIDELAERSESLEQRIASLNDSYETLKKREVELTEWRWVLREAGGFFDRAHTHTEEIRQSFDNDEAPLLRDVEQQNHRGANGDAQGQQSFLELNIGFVSGVIPRDRIGAFERILWRTLRGNLYMNQAEIPDPIVDPTTNEETQKMVFVIFAHGKNIIAKIRKISESLGASLYSVDENSELRRDQIHEVNTRLSDVNNVLRNTKNTLDAELSQIARSLAAWMIIVKKEKAVYDTLNKCSYDQARKTLIAEAWCPTNSLSLIKSTLQDVNDRAGLSVPSIVNQIRTNKTPPTYVRTNKFTEAFQTIVDAYGISKYSEVNPGLYTVVTFPFLFAVMFGDFGHGFLMALAAAAMIFWERQLSKTKLDELTYMAFYGRYIMLMMGIFSMYTGLIYNDIFSKSFTVFSSSWKWPDNIEQGQSVEASLKGSYRFPFGLDWNWHEAENSLLFTNSLKMKMSIILGWAHMTYALILQYVNARHFKSKVDIIGNFIPGIIFFQSIFGYLVLTIIYKWSVDWPARNQSPPGLLNMLIFMFLSPGNVEEELYPGQGGVQLCLLLLAVAQVPIMLFFKPFYLRREHNRARALGYRGLGEQSRVSALDEDGDLDGPRQSTASDGEGVAMIAQDLEEEHEEFDFSEIMIHQVIHTIEFCLNCISHTASYLRLWALSLAHQQLSIVLWDMTLGTAFDQEDGTIRTIMIIVTFYMWFTLTIAILCVMEGTSAMLHSLRLHWVEAMSKHFMGDGIPFAPFSFKTLLEEDPVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="108" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B215</accession>
    <accession>C8VGK8</accession>
    <name>Q5B215_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">O-methyltransferase, putative (AFU_orthologue AFUA_5G02640)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ANIA_05415</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF81948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_663019.1">
        <property type="nucleotide sequence ID" value="XM_657927.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B215"/>
    <dbReference type="STRING" id="227321.Q5B215"/>
    <dbReference type="GeneID" id="2871705"/>
    <dbReference type="KEGG" id="ani:ANIA_05415"/>
    <dbReference type="eggNOG" id="KOG3178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005533_1_4_1"/>
    <dbReference type="InParanoid" id="Q5B215"/>
    <dbReference type="OMA" id="LNDWVGY"/>
    <dbReference type="OrthoDB" id="1606438at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012967">
        <property type="entry name" value="COMT_dimerisation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF5">
        <property type="entry name" value="O-METHYLTRANSFERASE ASQN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08100">
        <property type="entry name" value="Dimerisation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase dimerisation" evidence="6">
        <location>
            <begin position="90"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="5">
        <location>
            <begin position="277"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBF81948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="459" mass="50687" checksum="10A782C2AC637CA0" modified="2005-04-26" version="1">MANRDNETNSPNLSLTALASQISSCASLIDTFLLSNNHPTPSFAPDAPAAFPAAPANVQHARQSLIEAAQSLIDLLTGPAEHLRWLACRYHDMSSLRWIYHFKIAPAIPLDRAVSYADVAAKTGVDEDHLKRMLRHAMTNRLFIEPEPGMVAHTASSALLVTSRALNDWVGYTTEETFPASAKVVEAQERFGASRSPTETGYNVAFGTAKPMFEHMAEDQERERRFANTMVEMTSTEGYGIHHLVDGYGWDQIGKAKVVDQQGLGILAFRADAYVDIQVGGSTGHACIAIAKKAPEATFLVQDLAGVVDQGRASLPESLSSRITFKEHDFFTSQPEEADIYLLRFILHDHPDSTAIDIVKNLIPAMRQGARLIINDGVYPEVNTLPKGEERIARIMDLEMLTTFNARERPLADWVKLCADADSRLKLRSVSKPEGSVMSILEFVFDEPESKFDESLVDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="132" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B275</accession>
    <accession>C8VGS0</accession>
    <name>Q5B275_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">alcohol dehydrogenase (NADP(+))</fullName>
            <ecNumber evidence="9">1.1.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">ANIA_05355</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a primary alcohol + NADP(+) = an aldehyde + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15937"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15734"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:15938"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="10">
            <dbReference type="Rhea" id="RHEA:15939"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.2" evidence="9"/>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF82047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_662959.1">
        <property type="nucleotide sequence ID" value="XM_657867.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B275"/>
    <dbReference type="STRING" id="227321.Q5B275"/>
    <dbReference type="GeneID" id="2871647"/>
    <dbReference type="KEGG" id="ani:ANIA_05355"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN5355"/>
    <dbReference type="eggNOG" id="KOG0023">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_20_2_1"/>
    <dbReference type="InParanoid" id="Q5B275"/>
    <dbReference type="OMA" id="MEWGQFE"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008106">
        <property type="term" value="F:alcohol dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006066">
        <property type="term" value="P:alcohol metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd05283">
        <property type="entry name" value="CAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000158">
        <property type="entry name" value="Zinc-binding alcohol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047109">
        <property type="entry name" value="CAD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42683">
        <property type="entry name" value="ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="12">
        <location>
            <begin position="16"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CBF82047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="359" mass="38525" checksum="BE342AD2EA77ED96" modified="2005-04-26" version="1">MSTDYKFEGWLGLDAGSVDGKMQWKEFEPKPWEETDVDIKISHCGICGSDLHTLRSGWGPTNYPCCVGHEIVGTAVRVGSQVKHIKVGDRVGVGAQSESCVGRKGECNECATSNEPYCTKHFAGTYNGVFMNGGKSYGGYALYNRSPAHFAIKIPDAIPSAHAAPMMCGGVTVYSPLKHYGCGPGKTVGIIGIGGLGHFGVLFAKALGADRVVAISRKSDKRADALKLGADEYVATAEDTEWMANNKRSLDLIVCTVSSSKMPINDYVSLLKVDGTMIQVGAPEDGALTIPAFTLIANRVKLGGSLIGSPDTIREMLELAAEKGVKPWVEERPMKDANQAIKDMDAGDARYRYVLVNDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B2I9</accession>
    <accession>C8VFC0</accession>
    <name>Q5B2I9_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ANIA_05241</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF81151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_662845.1">
        <property type="nucleotide sequence ID" value="XM_657753.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B2I9"/>
    <dbReference type="GeneID" id="2871532"/>
    <dbReference type="KEGG" id="ani:ANIA_05241"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN5241"/>
    <dbReference type="HOGENOM" id="CLU_966525_0_0_1"/>
    <dbReference type="InParanoid" id="Q5B2I9"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF81151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="288" mass="32330" checksum="C34F0C95102D512E" modified="2005-04-26" version="1">MTENPYLHPGFAGFKPRPSHQRLALCVFLGALLHTAAVNSFNGFDLWEQKTTAICSSSLLLYRTPPVTCLALTPYPKQRALLLPISNGVKSSPPNINERSFSSSPRFRHKAFDTPADERQVPAWVISMTEVEVTASNEVKTRSRSYTIKGTPIVALTREVGDVGDSDAYISSFTYHLYTHPDDHDARFEDRLVTGIAVKMVTYRACYSDDEHDFFGDYLDWDQVHLWSPPYEPFLLLSIIYTDAFWLVRCEACGNQERASSSLKADAGPAQVSRQILPETTRSMGRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="101" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B355</accession>
    <accession>C8V860</accession>
    <name>Q5B355_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Flavin containing amine oxidase, putative (AFU_orthologue AFUA_3G12150)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_05025</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF76255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_662629.1">
        <property type="nucleotide sequence ID" value="XM_657537.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B355"/>
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    <dbReference type="STRING" id="227321.Q5B355"/>
    <dbReference type="GeneID" id="2872822"/>
    <dbReference type="KEGG" id="ani:ANIA_05025"/>
    <dbReference type="eggNOG" id="KOG0029">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004498_7_1_1"/>
    <dbReference type="InParanoid" id="Q5B355"/>
    <dbReference type="OMA" id="YVTFPRA"/>
    <dbReference type="OrthoDB" id="5046242at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0000318"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0140682">
        <property type="term" value="F:FAD-dependent H3K4me/H3K4me3 demethylase activity"/>
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        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0000318"/>
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    </dbReference>
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        <property type="term" value="P:epigenetic regulation of gene expression"/>
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    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050281">
        <property type="entry name" value="Flavin_monoamine_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742:SF414">
        <property type="entry name" value="CONTAINING AMINE OXIDASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12150)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742">
        <property type="entry name" value="FLAVIN MONOAMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00419">
        <property type="entry name" value="ADXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amine oxidase" evidence="2">
        <location>
            <begin position="14"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="Amine oxidase" evidence="2">
        <location>
            <begin position="424"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="544"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="588"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="544"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="594"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="623"/>
            <end position="644"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF76255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="657" mass="71797" checksum="F3E686D639C35F9B" modified="2005-04-26" version="1">MSRRPNVAIIGAGFAGLRCADILIQNGAQVTIFEARDRVGGRVHQCKVGGHLVDMGPNWIHGAGANPVLDIARATRTTLHDFEGSQLVFGSNGKALDERVAMKISEILWTTIDEAFTYSNNHEADIPAEKSLLDFIRERLQETNLTEDEKRLCIDTARLWGCYIGDPIERQSLKFFSLEESIDGSNYFVASTYKDILAQVSSTALQHADIRLNQPIVNIHSKPIIQGTSTRREITITTQTGERHAFDEVVVTCPLGWLKRNKEAFTPELPPRLSSAIDAISYGRLEKVYITFPEAFWHTKSTGNTVTLPTVSASAANGTNTKLSFAQFLTPLYYTDHPEEVPWDQECFSLAALPKDTAHPTLLFYTYGPCATYIVNKLTSLSSTTTEVTNSHSHAPSSKQYTFLNTLFAPFYSLLPNYIPNTKACTPTSILATTWQADPNAGHGSYSNFQVGLVDGNKDIETLRAGMGLDRGVWFAGEHTAPFVALGTTTGALWSGERAAGQICALYRLGRVGMGVERDDSLPSGNGNGSMGVFSEGANGKGGSGFRVGGGSATGVRNGGEGGERDALFSQLDTRQYTWVAGQCKAVHERKNKQASGSNPVKQNMGNPDKQTKARSQPNPDRTQPRSKQEGQTRNEADEDRSREALWGILIECNEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B3C2</accession>
    <accession>C8V914</accession>
    <name>Q5B3C2_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribonuclease H2 subunit B</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Ribonuclease HI subunit B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ANIA_04958</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF76396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_662562.1">
        <property type="nucleotide sequence ID" value="XM_657470.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B3C2"/>
    <dbReference type="STRING" id="227321.Q5B3C2"/>
    <dbReference type="GeneID" id="2872757"/>
    <dbReference type="KEGG" id="ani:ANIA_04958"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN4958"/>
    <dbReference type="eggNOG" id="ENOG502SCDS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057573_0_0_1"/>
    <dbReference type="InParanoid" id="Q5B3C2"/>
    <dbReference type="OMA" id="YYFCPKL"/>
    <dbReference type="OrthoDB" id="29098at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032299">
        <property type="term" value="C:ribonuclease H2 complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd09270">
        <property type="entry name" value="RNase_H2-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.120:FF:000004">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040456">
        <property type="entry name" value="RNase_H2_suB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019024">
        <property type="entry name" value="RNase_H2_suB_wHTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041195">
        <property type="entry name" value="Rnh202_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13383">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13383:SF11">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09468">
        <property type="entry name" value="RNase_H2-Ydr279"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17745">
        <property type="entry name" value="Ydr279_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rnh202 triple barrel" evidence="8">
        <location>
            <begin position="34"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="Ribonuclease H2 subunit B wHTH" evidence="7">
        <location>
            <begin position="112"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="227"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="360"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="360"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00033464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF09468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBF76396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="419" mass="46041" checksum="6A09D9D460ECBCE0" modified="2005-04-26" version="1">MRTRSAPPPKQSASEKQAQPEPSKATMKPSKAFILPTSASSDARFVTLPNPRTGDLTRYFFCPKLGVYEFTVVASQSPRSILYTSKSVSGKPQGSISKTAELLVATPIDILFFAIPLLCSVSSSNEGKRLFQPLDDIIDSHDDLPEHLRYILYNDTFRSTLLRRVEAVCDSVEAGDERVFRVSETKLLQELLAKAERMAVQGLPKSLEERFVKQALAVPLVSVTRTDVATSSAPAKEDHNGIESQESNDTQSTSATTSNSSVSRTSTPAESAPTPATEELPEQQACPDSIVRLQRLSVALAFLKTSYISAAVCAKIDELLSAPASPIDFKPLHDYLKHLADLRAEALASRSLGDFSRKRNVEDDDVVESRAEKKRRTEEEEKKKKASESRGVRELKKVNTSGMKKMSDFFGKAAPKKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B401</accession>
    <accession>C8VAU6</accession>
    <name>Q5B401_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF1479 domain protein (AFU_orthologue AFUA_5G09280)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ANIA_04729</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF76910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_662333.1">
        <property type="nucleotide sequence ID" value="XM_657241.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B401"/>
    <dbReference type="STRING" id="227321.Q5B401"/>
    <dbReference type="GeneID" id="2872529"/>
    <dbReference type="KEGG" id="ani:ANIA_04729"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN4729"/>
    <dbReference type="eggNOG" id="ENOG502QUAF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011148_0_0_1"/>
    <dbReference type="InParanoid" id="Q5B401"/>
    <dbReference type="OMA" id="NKACFGQ"/>
    <dbReference type="OrthoDB" id="8249012at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010856">
        <property type="entry name" value="Gig2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30613:SF1">
        <property type="entry name" value="DUF1479 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G09280)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30613">
        <property type="entry name" value="UNCHARACTERIZED PROTEIN YBIU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07350">
        <property type="entry name" value="Gig2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF76910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="476" mass="53311" checksum="8BAAD8D88984E670" modified="2005-04-26" version="1">MSVPKLITRSTARAASTSTSAQLTKAAGDISSVFPSLRPDYKPEPLPPRFKDLKERIFRRNGDALKKSWERLLPSLEEEVDKIKAKKSGIIPIVDYSDVVSGDVSPALLAEIRHRGSVVIRNVVPRKEARAWKERIEDYVAANQDKVKAFPPDSPAVFELYWTPSQAEARAHSNVLDTQRFLQRLWHSTDPNTRISTRYPLSYADRLRIRQPGDSKFTLGPHIDGGSLERWEDPEYSRVYAKILEGKWEEYDPWDAKHRIAANMDLYNGAGACSMLRFFQGWLSMSKTAPGEGSLHVCPMLVHSTAYTMLRPFFDSQTLQPAMDATFPGSVPGACQEYNPITHPHLELETTMVSVPEVEPGDYVAWHCDSLHSVDKEHRGKGDSSVLYIPATPMCDMNVDYLLKQRKAALAYSPPWDFPGAGGPGELGFKGALDWNSISAEGQRAMGLGQQRWDITDDMTEGERQAVERANKACFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="113" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B411</accession>
    <accession>C8VAV6</accession>
    <name>Q5B411_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ANIA_04719</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
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            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
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    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="4">
        <location>
            <begin position="501"/>
            <end position="690"/>
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            <begin position="874"/>
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            <begin position="1"/>
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    <feature type="region of interest" description="Disordered" evidence="3">
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            <begin position="221"/>
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            <begin position="38"/>
            <end position="63"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="113"/>
            <end position="123"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
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    <sequence length="1199" mass="135310" checksum="84C5CC840578959D" modified="2005-04-26" version="1">MADIGGQQGRNYRPHGHPSSVQRDAAFSEIFGGARQPGRSQTMTSQTPQFSQERAHTMSSQVPRPQMQRGPLPPQRPMQNGYPPSQSNGYYQAYPGSATMTSQSPQGPPRPYPGRYAYPQPQRLDSRPVPGPPYQDAKGYNRAIPHPALNSDPYRSRSMARLGGPPIQPPQPNSFNHTSAIASRNQPYNPATPMTPQGRVVPERHGNERAMSLTSYSMDREPMHTTRTGSGRVIPNRRQPSGPVQPPIAQHDDYSDYMNGRVRPPSDGPMPNPRTFSMASTVAPDRTMSMQSNLTHRPSAQTTTTLVSNNSRRSKLLAVNPALLSRVADAFREQIPLGEKQKNGLSYQNAFSGADAVDVICSIIKTTDRNLALLLGRALDAQKLFHDVTYDHRLRDAPGELYQFKETLGEEAPSSEVNGVFTLLTECYSPTCNRDSLCYSIACPRRLEQQARLNMNPLPVLRTSASKSSLHGDDDGGDNQKLWINMVPKEVSDSVDDKEKKRQEIIFEIMYTERDFVKDLEYLRDFWMRPLRSASNSPIPEHRREKFIRTVFGNCLDVLKVNGALSEALNARQKESHIVKTVGDIFLQHVPRFDPFIKYGANQLYGRYEFEKEKSSNPAFAKFVEETERLKESRKLELNGYLTKPTTRLARYPLLLEQVGKNTAEGSADKEDIPHAIRIIKDFLSRVNAESGRAENHFNLVSLNSSLKFGPGDYVDLKLTEENRQMLTKMAFKKTPTDNSEVTVYLFDHAVLLVRIKVVNKREEYRVYRKPIPLELLVIPQMDEVIPKPGIAKRPSSGLLANKTAANPPAAKDTLPITFRHLGKGGYEQTLYASSSQQRKKFLELVDEQQTKLRERNSNFYNKNIICEKFFNSVNRVNCLVPIDGGRKLVYGTDSGIYVSDRNPRDQSAKPRKVLDVSQVTQIDTLEEYQLLLVLANKTLYSYPMDALEVTEGQNPAAKRPKKIQGHANFFKSGIGLGRHLVCSVKTSALSTTIKVYEPMDNLAKGKKKSTVSKMFQSGQDTLKPFKEFYIPAESSSIHYLRSTLCVGCARGFEVVSLETTETQSLLDQADTSLDFVARKENVKPIHIERLNGEFLLNYSDFSFFVNRNGWRARADWKISWEGNPNSFALSLPYILAFEPNFIEFRHIDTSELIHIMTGKNIRMLHSSTREILYAYEDDSGEDVVASLDFWKHKPLAQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B574</accession>
    <accession>C8V988</accession>
    <name>Q5B574_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">JmjC domain protein, putative (AFU_orthologue AFUA_4G05980)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ANIA_04306</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF77800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_661910.1">
        <property type="nucleotide sequence ID" value="XM_656818.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B574"/>
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    <dbReference type="KEGG" id="ani:ANIA_04306"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN4306"/>
    <dbReference type="eggNOG" id="ENOG502QW48">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003774_2_1_1"/>
    <dbReference type="InParanoid" id="Q5B574"/>
    <dbReference type="OMA" id="WLKDNHG"/>
    <dbReference type="OrthoDB" id="298344at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018866">
        <property type="entry name" value="Znf-4CXXC_R1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02373">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10497">
        <property type="entry name" value="zf-4CXXC_R1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
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        <source>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="PROSITE" id="PS51184"/>
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        <source>
            <dbReference type="EMBL" id="CBF77800.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="720" mass="82851" checksum="4284B02BFB6F345D" modified="2005-04-26" version="1">MPAQRPRAAFEPISPALDAAELIKSSPNFEEVVRIHCDAIDENGLENFEKLVLLHVIVRGLPLVVEGFDKKLDNAIFSERWLRSHYSAKREDARDLTAKKAVPLTIGHYLKNMSILANQFNKFNHKNPDLQRLYLKDIDCPKIWHDFLKSIIPPFLFYLNNLAEPEFFESTGPKSAPFSKKRKVSQEQVGKAGDLMSCLPENMRAENLMCYIGHEGTYTPAHQEMCASLGQNLMVEASDGSIENGKATKPGSSLWFMTSSKDRNSVSEYWMTMLGHDINLEDHFAQINAWKAAPFTTYIVEQRPGDFILIPPLAAHQVWNRGTRTMKVAWNRTTVETLERALNEALPHARVVCRDEQYKNKAIVFYSLKQYSTRLNSVDANRSPARVQQLQNEFEQLFSLFNQILLSESFSTATPHEKNVEYIPFDSNITCAYCRGNIFNRFLTCPSCATTATGVELPYDICMECYVMGRSCACISELKWVEQFKWEQLLRMHEFWRQQVLRFDPELDKKYRQFRVEKEEMGKKSLAHICQEELKRRPWVDISKPKPIMEELVDGISELEDDTRPARRRKKSKSKGPKCHICKYVEPEWKLASCSNPKCSLRYCYGSLFRAFNMLPQEVLETSKWECPRCQKFCSCGGCRKNPQMTPFEPTCTSLGHDTSQVADVRSIEALVDFGHSNLGWLKKASSDEISRLSKHQEEADVKRNQALEITQYRSRSTLT</sequence>
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<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B589</accession>
    <accession>C8V9A2</accession>
    <name>Q5B589_EMENI</name>
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        <recommendedName>
            <fullName evidence="4">Transposase Tc1-like domain-containing protein</fullName>
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    <gene>
        <name evidence="2" type="ORF">ANIA_04291</name>
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        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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            <taxon>Aspergillus subgen. Nidulantes</taxon>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
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            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
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        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF77827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="XP_661895.1">
        <property type="nucleotide sequence ID" value="XM_656803.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B589"/>
    <dbReference type="GeneID" id="2872091"/>
    <dbReference type="KEGG" id="ani:ANIA_04291"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN4291"/>
    <dbReference type="eggNOG" id="ENOG502QUTZ">
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    <dbReference type="HOGENOM" id="CLU_138658_0_0_1"/>
    <dbReference type="InParanoid" id="Q5B589"/>
    <dbReference type="OMA" id="VQWTCES"/>
    <dbReference type="OrthoDB" id="4890185at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13384">
        <property type="entry name" value="HTH_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="87"/>
        </location>
    </feature>
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        <location>
            <begin position="134"/>
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        </location>
    </feature>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="CBF77827.1"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="162" mass="18570" checksum="422217226DFAB8AD" modified="2005-04-26" version="1">MAIPRPSTPPEAPLEVTEISERSQSSRWLSRDDRIRILTLRDAGFTYQQISSQLGFTYRQVQYTCQNEQSTPRKPPGQRPKLSEEDMDNIITFISSSQRTRRLSYKRVIEELNLPCGETALARALKKRGYSRCKALRKPPLSDDTKRASIPESGLPEEQEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="106" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B5R1</accession>
    <accession>C8V516</accession>
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        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
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    <gene>
        <name evidence="8" type="ORF">ANIA_04119</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
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        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
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            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF74667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_661723.1">
        <property type="nucleotide sequence ID" value="XM_656631.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B5R1"/>
    <dbReference type="FunCoup" id="Q5B5R1">
        <property type="interactions" value="79"/>
    </dbReference>
    <dbReference type="GeneID" id="2873534"/>
    <dbReference type="KEGG" id="ani:ANIA_04119"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN4119"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_11_4_1"/>
    <dbReference type="InParanoid" id="Q5B5R1"/>
    <dbReference type="OMA" id="RKWPLTI"/>
    <dbReference type="OrthoDB" id="9986881at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF138">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="215"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="290"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="326"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="367"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="398"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="429"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="463"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="58"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBF74667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="494" mass="53351" checksum="E2B455914D1AFC67" modified="2005-04-26" version="1">MTLSDAQQEWAPTEKCSIGAGKPFPPALPDQERYTVDFEGPDDPMHPQNWPLTIKLISSIMACSGTLIASLNSAIFSTAADQASRDFDVGREVISLGTALFVLGFATGPVFWAPMSELTGRKLPLVIAILSEGIFTVGCAAAQEVQTLIICRFFAGVCGASQLTVVPGVLADLYNNAHRGVAIGLYALTVFGGPFIAPIAGGFMASGHLGWRWTLYIPAILALAIGALSILFLKETYPPCILAVKASGIRKKRPENWAIHAEQETVELDIAVLVEKYFNRPLRLLVTEPMLLLISLYMSFIYGLVYALLQAFPYVFEHIHGLHPGLAGLMFVGLIIGVVLALCFILSQQAQYAKALAENGNVPVPEWRLRPAMLGAPIFALGLFWFGWTGFTPRIHWAAPAAAGIPIGFGILCIFFPCFNYLVDAYLPVAASAVAANIILRSAFASGFPLFTRQMFETMGVQWAATLLGCLATVLVPIPFVFKALGPRLRRTAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B6P1</accession>
    <accession>C8V703</accession>
    <name>Q5B6P1_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF52 domain protein (AFU_orthologue AFUA_2G03970)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_03789</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MEMO1 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF75380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_661393.1">
        <property type="nucleotide sequence ID" value="XM_656301.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B6P1"/>
    <dbReference type="FunCoup" id="Q5B6P1">
        <property type="interactions" value="495"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5B6P1"/>
    <dbReference type="GeneID" id="2873212"/>
    <dbReference type="KEGG" id="ani:ANIA_03789"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN3789"/>
    <dbReference type="eggNOG" id="KOG3086">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038085_0_0_1"/>
    <dbReference type="InParanoid" id="Q5B6P1"/>
    <dbReference type="OMA" id="MHLPYIH"/>
    <dbReference type="OrthoDB" id="417112at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="CDD" id="cd07361">
        <property type="entry name" value="MEMO_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.830.10">
        <property type="entry name" value="LigB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00055">
        <property type="entry name" value="MEMO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002737">
        <property type="entry name" value="MEMO1_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR04336">
        <property type="entry name" value="AmmeMemoSam_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11060">
        <property type="entry name" value="PROTEIN MEMO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11060:SF0">
        <property type="entry name" value="PROTEIN MEMO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01875">
        <property type="entry name" value="Memo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF75380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="366" mass="39931" checksum="DAA4F4D6F6DD4D76" modified="2005-04-26" version="1">MGFRAASHAGSWYSGNRQTLALQLDQWLDRVPGTLEGLGSLPAPGARIIIAPHAGYSYSGPCAAYAYKALDLSKAKRIFVLGPSHHHYFTSLALPTLTGYYTPLSDDPLPLDTELIAKLRSTPAAKSNGSTIAFEDMSQSVDEDEHSIELHLPYIHRLLQLQHPDKKAAEYPPLVPILVGSTSKATEAAFGALLAPYLEDPSNAFVVSSDFCHWGLRFRYTYYVPQAPVPGPRLPLSSYDLPQPEDDETEIESKIEVACAGYHLKRRDPIRRGKPLIHESISSFDIATMAAIATGKTERFTDILEKTGNTVCGRHPIGVIMAAIEAAGKQEGGKGKFHFARYERSSDIGEIVEDSSVSYVSAFAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B725</accession>
    <accession>C8V3V5</accession>
    <name>Q5B725_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Complex I-ESSS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">NADH-ubiquinone oxidoreductase ESSS subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">ANIA_03655</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="19">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Complex I is composed of 45 different subunits. Interacts with BCAP31.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I NDUFB11 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF75681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_661259.1">
        <property type="nucleotide sequence ID" value="XM_656167.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B725"/>
    <dbReference type="STRING" id="227321.Q5B725"/>
    <dbReference type="GeneID" id="2873070"/>
    <dbReference type="KEGG" id="ani:ANIA_03655"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN3655"/>
    <dbReference type="eggNOG" id="ENOG502S7S9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_138649_2_1_1"/>
    <dbReference type="InParanoid" id="Q5B725"/>
    <dbReference type="OMA" id="EDWEDIW"/>
    <dbReference type="OrthoDB" id="2147978at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019329">
        <property type="entry name" value="NADH_UbQ_OxRdtase_ESSS_su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40637">
        <property type="entry name" value="ESSS SUBUNIT OF NADH:UBIQUINONE OXIDOREDUCTASE (COMPLEX I) PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40637:SF1">
        <property type="entry name" value="ESSS SUBUNIT OF NADH:UBIQUINONE OXIDOREDUCTASE (COMPLEX I) PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10183">
        <property type="entry name" value="ESSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="13 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="7 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="65"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00031387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00046528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CBF75681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="113" mass="12899" checksum="1ED19D57B44F29D6" modified="2005-04-26" version="1">MTLRPLSHCLRARCIRRSAQNIQGFSTRTNLRGGADHGDHYDPPTGYLFGVKPGQKYVKEGWENIWYYGFIGSLLVAGVAYVFKPDTSIQTWALEEARRRLEAEGILEDPQRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="127" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B7N2</accession>
    <accession>C8VHB8</accession>
    <name>Q5B7N2_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Component of the RSC chromatin remodeling complex (Eurofung)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">ANIA_03448</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF82685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_661052.1">
        <property type="nucleotide sequence ID" value="XM_655960.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B7N2"/>
    <dbReference type="FunCoup" id="Q5B7N2">
        <property type="interactions" value="292"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5B7N2"/>
    <dbReference type="GeneID" id="2874256"/>
    <dbReference type="KEGG" id="ani:ANIA_03448"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN3448"/>
    <dbReference type="eggNOG" id="KOG1827">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007728_0_0_1"/>
    <dbReference type="InParanoid" id="Q5B7N2"/>
    <dbReference type="OMA" id="QKWINAC"/>
    <dbReference type="OrthoDB" id="1742084at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016586">
        <property type="term" value="C:RSC-type complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd04717">
        <property type="entry name" value="BAH_polybromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05522">
        <property type="entry name" value="Bromo_Rsc1_2_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04369">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.490:FF:000015">
        <property type="entry name" value="Chromatin structure-remodeling complex subunit RSC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.10:FF:000048">
        <property type="entry name" value="RSC complex subunit (RSC1), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.10:FF:000069">
        <property type="entry name" value="RSC complex subunit (RSC1), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001025">
        <property type="entry name" value="BAH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043151">
        <property type="entry name" value="BAH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018359">
        <property type="entry name" value="Bromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037382">
        <property type="entry name" value="Rsc/polybromo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048047">
        <property type="entry name" value="RSC1/2_bromodom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16062:SF21">
        <property type="entry name" value="CHROMATIN STRUCTURE-REMODELING COMPLEX SUBUNIT RSC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16062">
        <property type="entry name" value="SWI/SNF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01426">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00439">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="2"/>
    </dbReference>
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    <keyword evidence="3" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
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        <location>
            <begin position="56"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="10">
        <location>
            <begin position="261"/>
            <end position="323"/>
        </location>
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        <location>
            <begin position="366"/>
            <end position="485"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="154"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="522"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="154"/>
            <end position="190"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="204"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="522"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
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            <begin position="559"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="583"/>
            <end position="592"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
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    </evidence>
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        <source>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="10">
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            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51038"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CBF82685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="884" mass="100545" checksum="E3883B6D616E834E" modified="2005-04-26" version="1">MEKASEPSQAQPTPEEPVQSIEDDGKQNGVTSTVTEEQWKHMMDVVLAIYEVREADGHDPSRLFHRSVNKRNVPDYYDIIKEPMALSILKQKINKREYKSVSEFVRDCALIPHNAQTYNRPNSQAYEDSLVIKDAFVTELQKLVQAGIITAEEAELPDLGEIPEPDPLPEEDDDEDEDDEDDDDDEDSDDEGRRRKKRGPRPGFKRDGAKDDASKSADPEQRKKRGRPPRVDTPMEARIKAVLKGIRKLKGPGNQLKVRHFERLPDKGVYPDYYVEIKEPIAIDLIKRKSKRKKYNSVDHFMKDMDLMFNNAKAYNQPESQIYKDAVDLQMEARRLADLEKKKPDSDYLMEDGRLPLPDGILHKGELWKVGDWVHIQNPNDVTKPIVAQIYRTWQDSEGEKWINACWYYRPEQTVHHFEKHFYPNEVVKTGQYRDHRINEIVDRCFVMFFTRYNRGRPRDFPLDKEIYVCEARYNEEKHKLNKIKTWASCLPDEVREKDYEMDLYDVPRRIKKIPSPIKHLLKSDAKETDDLPKPSWGAENAPPVVGAVHCRPRDENESPPPEPTPSPPPPAIPPSALPSVSRQASMSQAPTQPVINSPAALLAAASPVPVRSPAAHVGPAQHSPAPAPPIPYHQPQVPYQTAIQQRRSSGFVNQNIIPGTYQGPTPPLPYAVPQGPHYTPYQLSRAQGAPTMYNSNAPRPVEVFHLSDTANAAIPADIREQFHCDDQGHVLFFSCAPLDIGSAVQQKLGHSLKYLAAKEERRKLVEAKKRKEISEREERERANKRQCADKQRALAVQVEAVAEKAVEIMTNEIVKGTDKIYEALYQDQAESAREADTKAREERILRARAIQTKTAQIQGKSTKPTFVSLKGSGMYLDEIDPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B7Z6</accession>
    <accession>C8VHV7</accession>
    <name>Q5B7Z6_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_03334</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF82922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_655846.2"/>
    </dbReference>
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    <dbReference type="GeneID" id="2874135"/>
    <dbReference type="KEGG" id="ani:ANIA_03334"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN3334"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073157_0_0_1"/>
    <dbReference type="InParanoid" id="Q5B7Z6"/>
    <dbReference type="OMA" id="HRGQLMT"/>
    <dbReference type="OrthoDB" id="10254221at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF22">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CBF82922.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="328" mass="35558" checksum="1C7B8EF367201D00" modified="2005-04-26" version="1">MSRNLVITSIESLTGSQIAKTILASRSFAKGIKKITGLTLYPDSDACAELKEEHGVQIVEHKPGNLDAMVSTLQETGADTICLLPPGHKDAFNITTELITATKKAGIPNVCFISSAGCDLAEREAQPLLRSVIDLEAMVMEAKGDASTETGHSPVVIRRGFYAEHLLLYSRQAQEEGKLPLPIGTSHKFAPMALSDVVEVVAHVLTGHGKHGFSDKHRGQLMVLTGPQLTAGDELATAASQALGKELKFEDISESEAKKVLKDDAGSSEGEIAYLLEYYALVREGKTNYISTTAFHDVTGKHPVEPTEFFKQYAENLRPKANKKRKTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="104" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B804</accession>
    <accession>C8VHW8</accession>
    <name>Q5B804_EMENI</name>
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        <recommendedName>
            <fullName evidence="6">GH26 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ANIA_03326</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 26 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF82942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_660930.1">
        <property type="nucleotide sequence ID" value="XM_655838.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B804"/>
    <dbReference type="STRING" id="227321.Q5B804"/>
    <dbReference type="CAZy" id="GH26">
        <property type="family name" value="Glycoside Hydrolase Family 26"/>
    </dbReference>
    <dbReference type="GeneID" id="2873867"/>
    <dbReference type="KEGG" id="ani:ANIA_03326"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN3326"/>
    <dbReference type="eggNOG" id="ENOG502QT55">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_813879_0_0_1"/>
    <dbReference type="InParanoid" id="Q5B804"/>
    <dbReference type="OMA" id="NWAYWMV"/>
    <dbReference type="OrthoDB" id="5286354at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016985">
        <property type="term" value="F:mannan endo-1,4-beta-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006080">
        <property type="term" value="P:substituted mannan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022790">
        <property type="entry name" value="GH26_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000805">
        <property type="entry name" value="Glyco_hydro_26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40079:SF4">
        <property type="entry name" value="GH26 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40079">
        <property type="entry name" value="MANNAN ENDO-1,4-BETA-MANNOSIDASE E-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02156">
        <property type="entry name" value="Glyco_hydro_26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00739">
        <property type="entry name" value="GLHYDRLASE26"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51764">
        <property type="entry name" value="GH26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030175778" description="GH26 domain-containing protein" evidence="5">
        <location>
            <begin position="22"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="GH26" evidence="6">
        <location>
            <begin position="50"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBF82942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="341" mass="38475" checksum="692CE17333FB2DC3" modified="2005-04-26" version="1">MHGKLWYGLMALATLGSPALANPLLHGLGHKNTSINLNHLMARNTDKFDPADLSYITRLAAIGDSYLAGIGAGDMLDSEAGKSLSFLILNRVFQQPWNEYCSCYNYSYPYLIHTNEQLDLMYYSLSAVAHGSKSHAVEDAINFDRQGGISTLVWYWYAPTCLLDSEEQPWYSGFYTEATCFNIANTLSHSRNRTDYGLLIQDIDVIAAQLKRLSDANIPFWWRAHGPAAFKQLWDLIYNHITCVHDIHNLVWVCNTADPSWYPGNNKCDITTVDHYAEAGDHGVLKGKFEGLKNITRGERVLALAEVGSIPDPELQAKENVPWAYWMTWNDEFIKDGKKTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B8U4</accession>
    <accession>C8VIT7</accession>
    <name>Q5B8U4_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Membrane fusion mating protein FIG1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_03036</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF83525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_660640.1">
        <property type="nucleotide sequence ID" value="XM_655548.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B8U4"/>
    <dbReference type="FunCoup" id="Q5B8U4">
        <property type="interactions" value="17"/>
    </dbReference>
    <dbReference type="GeneID" id="2873747"/>
    <dbReference type="KEGG" id="ani:ANIA_03036"/>
    <dbReference type="eggNOG" id="ENOG502QUDU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068733_0_0_1"/>
    <dbReference type="InParanoid" id="Q5B8U4"/>
    <dbReference type="OMA" id="YFGICVN"/>
    <dbReference type="OrthoDB" id="3550957at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000747">
        <property type="term" value="P:conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033481">
        <property type="entry name" value="Dni1/Fig1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016509">
        <property type="entry name" value="Fig1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28092">
        <property type="entry name" value="FACTOR-INDUCED GENE 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28092:SF1">
        <property type="entry name" value="FACTOR-INDUCED GENE 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12351">
        <property type="entry name" value="Fig1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007138">
        <property type="entry name" value="FIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF83525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="275" mass="29630" checksum="360B03C69BDCFBD4" modified="2005-04-26" version="1">MPRFAGGFARFITMVGYHHVLMIIIAIIIILLSNSHNHSALLLAGCSSSSPQMPTIFLISMYYERYDPIFDLAQVDPGVVTATANIVGGAQLEVRVGYFGICVQPDGGSYICNNNATALAEILTLDQDPLNLVWVASTFKDAVVFPYLIIIAIILAFICFIILATFPGWHEGTDATGSEVEYKPFPSRPVSQVALALIFVAAVFVLVSVLWQHTASVGASTIAQDLGNGSVKSGVGTSAMVLGWFGFALMVVVTIGLLFMILNLRLLRQLTDDEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B9I2</accession>
    <accession>C8VJJ9</accession>
    <name>Q5B9I2_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RTA1 domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ANIA_02798</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF83992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_660402.1">
        <property type="nucleotide sequence ID" value="XM_655310.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B9I2"/>
    <dbReference type="GeneID" id="2873720"/>
    <dbReference type="KEGG" id="ani:ANIA_02798"/>
    <dbReference type="eggNOG" id="ENOG502QURG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033465_9_0_1"/>
    <dbReference type="InParanoid" id="Q5B9I2"/>
    <dbReference type="OMA" id="HSNTESI"/>
    <dbReference type="OrthoDB" id="3358017at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF35">
        <property type="entry name" value="RTA1 DOMAIN PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBF83992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="136" mass="14962" checksum="9099A695A5B42870" modified="2005-04-26" version="1">MATENNIYGYSPSIPAAGIFIVLFGISTAYHVYQLIKARALYFIPFVIGGIFQILGYIFRILGHNSPDSVPLYALQTVLILLAPALYAASIYMVLGRLIVHLAAEQHSLVRVNWMTKIFVTGDVISFLMQCGGYSG</sequence>
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<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B9Y5</accession>
    <accession>C8VHF5</accession>
    <name>Q5B9Y5_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ANIA_02645</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the trt14 isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF84287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="XP_660249.1">
        <property type="nucleotide sequence ID" value="XM_655157.1"/>
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    <dbReference type="AlphaFoldDB" id="Q5B9Y5"/>
    <dbReference type="STRING" id="227321.Q5B9Y5"/>
    <dbReference type="GeneID" id="2874214"/>
    <dbReference type="KEGG" id="ani:ANIA_02645"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN2645"/>
    <dbReference type="eggNOG" id="ENOG502R6TN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2306081_0_0_1"/>
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    <dbReference type="OrthoDB" id="3758478at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900560">
        <property type="term" value="P:austinol biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900563">
        <property type="term" value="P:dehydroaustinol biosynthetic process"/>
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        <property type="project" value="GO_Central"/>
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    <dbReference type="InterPro" id="IPR050977">
        <property type="entry name" value="Fungal_Meroterpenoid_Isomerase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39598:SF1">
        <property type="entry name" value="AUSTINOID BIOSYNTHESIS CLUSTERS PROTEIN F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39598">
        <property type="entry name" value="AUSTINOL SYNTHESIS PROTEIN F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBF84287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="100" mass="10917" checksum="9FF2DD5050F5D186" modified="2005-04-26" version="1">MASWSANCTQQILPFSLGVPASSRAEAQQVLPKLIEVLINYKAKIRKVVHDADRGTAALYVTSKADSRSRETSSERTTSITRNVDQSSNVVNNAVLILTK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2010-06-15" modified="2026-01-28" version="100" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BA89</accession>
    <accession>C8VPS5</accession>
    <name>ABFA_EMENI</name>
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        <recommendedName>
            <fullName>Probable alpha-L-arabinofuranosidase A</fullName>
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            <shortName>Arabinosidase A</shortName>
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        </recommendedName>
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    <gene>
        <name type="primary">abfA</name>
        <name type="ORF">AN2541</name>
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        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Alpha-L-arabinofuranosidase involved in the degradation of arabinoxylan, a major component of plant hemicellulose. Acts only on small linear 1,5-alpha-linked L-arabinofuranosyl oligosaccharides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>Hydrolysis of terminal non-reducing alpha-L-arabinofuranoside residues in alpha-L-arabinosides.</text>
            <dbReference type="EC" id="3.2.1.55"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text>Glycan metabolism; L-arabinan degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 51 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.55"/>
    <dbReference type="EMBL" id="AACD01000043">
        <property type="protein sequence ID" value="EAA64646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF87061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_660145.1">
        <property type="nucleotide sequence ID" value="XM_655053.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BA89"/>
    <dbReference type="SMR" id="Q5BA89"/>
    <dbReference type="STRING" id="227321.Q5BA89"/>
    <dbReference type="CAZy" id="GH51">
        <property type="family name" value="Glycoside Hydrolase Family 51"/>
    </dbReference>
    <dbReference type="GlyCosmos" id="Q5BA89">
        <property type="glycosylation" value="7 sites, No reported glycans"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CBF87061">
        <property type="protein sequence ID" value="CBF87061"/>
        <property type="gene ID" value="ANIA_02541"/>
    </dbReference>
    <dbReference type="KEGG" id="ani:ANIA_02541"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN2541"/>
    <dbReference type="eggNOG" id="ENOG502QQEX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010060_1_1_1"/>
    <dbReference type="InParanoid" id="Q5BA89"/>
    <dbReference type="OMA" id="PGRESDW"/>
    <dbReference type="OrthoDB" id="406864at2759"/>
    <dbReference type="UniPathway" id="UPA00667"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031222">
        <property type="term" value="P:arabinan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019566">
        <property type="term" value="P:arabinose metabolic process"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046373">
        <property type="term" value="P:L-arabinose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000322">
        <property type="entry name" value="Probable alpha-L-arabinofuranosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010720">
        <property type="entry name" value="Alpha-L-AF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055235">
        <property type="entry name" value="ASD1_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051563">
        <property type="entry name" value="Glycosyl_Hydrolase_51"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31776">
        <property type="entry name" value="ALPHA-L-ARABINOFURANOSIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31776:SF0">
        <property type="entry name" value="ALPHA-L-ARABINOFURANOSIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06964">
        <property type="entry name" value="Alpha-L-AF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22848">
        <property type="entry name" value="ASD1_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00813">
        <property type="entry name" value="Alpha-L-AF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0326">Glycosidase</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0624">Polysaccharide degradation</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000394601" description="Probable alpha-L-arabinofuranosidase A">
        <location>
            <begin position="20"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="71"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="303"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="362"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="486"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="565" mass="62771" checksum="18B9A9B5206AFBC3" modified="2005-04-26" version="1" precursor="true">MPLSAAIKSSLSVSVRADAKGLVGFANTGYNGITVLKQTYWTSFYMKGEYSGTVLLRLTGTDSGTVYGSRNLSVKSTGGKWTQYETTFEANESYVAENEWQLLFDAATAKGHPLHFGLVQLFPPTYKNRTNGLRNDIARPIADLKPKFLRFPGGNNIQADRPGDWHYPNTDALGLDEYLWWCEDMDMVPVLSVWDGKSYGGIVSGEELQPYLDDIKDELEVTLPLTLLSHPLRAYLTPNTNEQYLLGPPSTPFGALRARNGHPDPWPIQYIEIGNEDDYSGGCDTYPDRLVQIYDTIHASYPNLTLIANNMDENCLPEIPLPGLWHDYHYYRSADDLVAMFNYWDNHDRGDRVLVGEYGCRNDSNPDGVFWSFMQGSCAEAVHMIGLERNSDVVMMAAYAPLLQHFGYTQWSVCTPSASLAYLGIHPADRGEEQPTLFGFESRPNSLTLSTSYYVNRMFSTNQGSTVHKVHSTAGFGPLYWVATSNETAYQVKLANYGAANQTVNIRVPGVGRGVLEMISGPKDASNLPGDIKIVPVSRNIRAGKEGYTVHMPPWGVAVLVVVFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="101" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BC40</accession>
    <accession>C8VKJ0</accession>
    <name>Q5BC40_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_01890</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF85765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_659494.1">
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    <dbReference type="KEGG" id="ani:ANIA_01890"/>
    <dbReference type="eggNOG" id="KOG1577">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_023205_0_0_1"/>
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        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
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        <property type="entry name" value="AKR"/>
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        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
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        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF3">
        <property type="entry name" value="NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ALDKETRDTASE"/>
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    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF85765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="265" mass="30342" checksum="B6ABBF76D1C91AB5" modified="2005-04-26" version="1">MSTQHFLRPISQAGRLRPIKFWKSSTIPSRQIGNYAGKTFTVNTGAQIPAIGCRTFQDEEQQEGAVLEALKAGVDLYLLHHPCTFARGKDRFPKGEDGLMRMGETTYVDTWKALQEIMKRTRKARAIGVSNFSRDETKNLINAEMVSFFLVPLSQAYDGGNMNSFYRDVYWSNRRANLGRLLDEPVLSEIGAMYSKNPAHVVLAWSVNHGRSVIPKSTIPWQIRQNVESDFVLEEDMERIDELNADLRFNTPQETYRWLLYEGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BCW5</accession>
    <accession>C8VNB2</accession>
    <name>Q5BCW5_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_01615</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF85226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_659219.1">
        <property type="nucleotide sequence ID" value="XM_654127.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BCW5"/>
    <dbReference type="GeneID" id="2874627"/>
    <dbReference type="KEGG" id="ani:ANIA_01615"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN1615"/>
    <dbReference type="HOGENOM" id="CLU_430218_0_0_1"/>
    <dbReference type="InParanoid" id="Q5BCW5"/>
    <dbReference type="OMA" id="HINNARA"/>
    <dbReference type="OrthoDB" id="10255512at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="79"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF85226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="636" mass="72254" checksum="DDCD54F748F3D4F6" modified="2005-04-26" version="1">MSSTLSTPSLSQFPTPNQTPRLPTPPNSPEETHPHIMSAEENEILAQESTRLTESGDDFAPTITSLLNEYTDRMKQIQRRRLAEQKGEHEILYAKLRRQKDSALSGLKQAQDLTTRYKQELDAKVIEEEQLTEKMKTLEKLLAETATQLSDTTKAYAEKEEIWNSVMGPLARLENDNNEIREQLGEIKQQLEGTNASIAEERAISDRNLSELASVRDKLAEEKVQRAAVERRLNEQDDRVRLLSNRIIYLKASKLQLRSELNQARREAEQVNRLRSANEELGARCETLTRDVSDLRDVRHHHEDEIRRMKQQQDTMTGAIHHLTSEVQVEQKRSEQLQSSVSDLEQKRDGLNNQLQHLQGEYNDLTGALANAHEAARRAEICMQWVVIAHRARCRSLKAEVAELKSSRLPKVEAKRSLANIRRGNSPARLGVVERPPVTIRKPRWKNQTVNSITTSAAAYLFWLCKTTGLRSALYALTTSCNHEEIKARCQPGMIQIYQLYPNSKIGATQLKKRLANVGLPKDHDYSRPTSEVTDTKVLVEVHEDRAQEQAQQPAAIPSQFQPEHNNICKATGRILTVRHPRRIQERVAQKDDLGIPSAVLPAHGPSQSCSLGIRVGRRPSYYLRTFGQKPDRGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BDA7</accession>
    <accession>C8VME4</accession>
    <name>Q5BDA7_EMENI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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    <gene>
        <name evidence="2" type="ORF">ANIA_01473</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF84930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_659077.1">
        <property type="nucleotide sequence ID" value="XM_653985.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BDA7"/>
    <dbReference type="GeneID" id="2875215"/>
    <dbReference type="KEGG" id="ani:ANIA_01473"/>
    <dbReference type="HOGENOM" id="CLU_3351063_0_0_1"/>
    <dbReference type="InParanoid" id="Q5BDA7"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF84930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="37" mass="4128" checksum="2C63E458B4D3C088" modified="2005-04-26" version="1">MTRDFRTRVGAESRLEVDRPVRVGPGKPVKPSEPPPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="143" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BE59</accession>
    <accession>C8VT23</accession>
    <name>Q5BE59_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">ANIA_01171</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="18">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF88003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_658775.1">
        <property type="nucleotide sequence ID" value="XM_653683.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BE59"/>
    <dbReference type="FunCoup" id="Q5BE59">
        <property type="interactions" value="216"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5BE59"/>
    <dbReference type="GeneID" id="2876951"/>
    <dbReference type="KEGG" id="ani:ANIA_01171"/>
    <dbReference type="eggNOG" id="KOG0583">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002664_0_2_1"/>
    <dbReference type="InParanoid" id="Q5BE59"/>
    <dbReference type="OMA" id="NSADYRP"/>
    <dbReference type="OrthoDB" id="1928777at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902716">
        <property type="term" value="C:cell cortex of growing cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140472">
        <property type="term" value="C:cell cortex of non-growing cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031097">
        <property type="term" value="C:medial cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035841">
        <property type="term" value="C:new growing cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035842">
        <property type="term" value="C:old cell tip after activation of bipolar cell growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051523">
        <property type="term" value="P:cell growth mode switching, monopolar to bipolar"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030950">
        <property type="term" value="P:establishment or maintenance of actin cytoskeleton polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902408">
        <property type="term" value="P:mitotic cytokinesis, division site positioning"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903500">
        <property type="term" value="P:negative regulation of mitotic actomyosin contractile ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007009">
        <property type="term" value="P:plasma membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd12121">
        <property type="entry name" value="MARK_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14077">
        <property type="entry name" value="STKc_Kin1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000333">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.80">
        <property type="entry name" value="Kinase associated domain 1, KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028375">
        <property type="entry name" value="KA1/Ssp2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001772">
        <property type="entry name" value="KA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF82">
        <property type="entry name" value="KP78A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02149">
        <property type="entry name" value="KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103243">
        <property type="entry name" value="KA1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50032">
        <property type="entry name" value="KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 17" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="44"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="KA1" evidence="16">
        <location>
            <begin position="873"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="435"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="784"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="818"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="79"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="503"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="586"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="642"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="685"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CBF88003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="922" mass="102082" checksum="CD40B85E0C4B63BF" modified="2005-04-26" version="1">MASAGPATADGGAGHSHAASGHHLHATNVQSKRRTMIATPTGQWSLGKTLGAGSMGKVKVGKHLETGEQVAIKIVPRQSTEEHRSQREAERADRSKEVRTAREAAIVSLVNHPYICGMRDVVRTNYHWYMLFELVNGGQMLDYIISHGKLKEKQARKFARQIASALDYCHRNSIVHRDLKIENILISKTGDIKIIDFGLSNLFSPRSLLKTFCGSLYFAAPELLQARQYTGPEVDVWSFGIVLYVLVCGKVPFDDQSMPKLHAKIKSGVFEYPPGLTAECRHIISRMLVTDPKQRASLTEIMNHPWMNKGFSGPPDNHLPHREPLQLPLDPEVIEKMTGFEFGKPEYITAQLTKIIESEEYQHAIALNAREHPVPAHTDKKRGVFDFYKRRNSASRDTLSAPSAEAVQLGNDPLNAYSPLLSVYYLVKEKLDRERSESNPGALSIAQAPGDMLQVPDLAPPEAAHTNQYQVPGEKDTGRRSRPRARTHGDDEITEGMKNASLAPNHAQASHSPAASQPDTPAKKESTAAGLLRRFSTRRTKDRSRDRERSRLASPHQPSLNVQPPADSASPLSRGFSMRKNRRTEPSATAIPSTGSQPQHQDLLKTPGSVEPASRSNKYLERSISVSSGEPRHRRSRRTEGDSGSQPPQTSGSEYSAVPKDSTAGREQKIAPRTHASRTMSLGHARRESIQARRARRDAAREANVPEETDGEISGPGAALESANEEDLSKPVYLKGLFSVSTTSSKPLAFIRADIIRVLKQLAVDYVEIKGGFSCRHAPSIELDKVVDNGPPSPERQGQVSNHRRRISLGGLLNHDDGREELARTTTRRRHRAPDRSFVSNSEVSDEYLETRDTTVTSGERVVGETTTRVQSDTGGNLVLRFEILIVKVPLFSLHGIQFKKVSGGMWQYREMAKKILDALRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BED8</accession>
    <accession>C8VTK8</accession>
    <name>Q5BED8_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glutamine amidotransferase, putative (AFU_orthologue AFUA_1G11980)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ANIA_01092</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF88161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_658696.1">
        <property type="nucleotide sequence ID" value="XM_653604.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BED8"/>
    <dbReference type="FunCoup" id="Q5BED8">
        <property type="interactions" value="10"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5BED8"/>
    <dbReference type="GeneID" id="2876864"/>
    <dbReference type="KEGG" id="ani:ANIA_01092"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN1092"/>
    <dbReference type="eggNOG" id="KOG1268">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042555_4_1_1"/>
    <dbReference type="InParanoid" id="Q5BED8"/>
    <dbReference type="OMA" id="SVHPAWN"/>
    <dbReference type="OrthoDB" id="14446at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061672">
        <property type="term" value="C:glutathione hydrolase complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036374">
        <property type="term" value="F:glutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008242">
        <property type="term" value="F:omega peptidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd01908">
        <property type="entry name" value="YafJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000045">
        <property type="entry name" value="Glutamine amidotransferase DUG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026869">
        <property type="entry name" value="EgtC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052373">
        <property type="entry name" value="Gamma-glu_amide_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43187">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE DUG3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43187:SF1">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE DUG3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13230">
        <property type="entry name" value="GATase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="3">
        <location>
            <begin position="2"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="334"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="334"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="371"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBF88161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="381" mass="42221" checksum="13564B13530E9620" modified="2005-04-26" version="1">MCRFLVYKGRHEIRLSKLVTEPSHSILTQSYDSRLRLDNRRPVNGDGFGVGFYTDPKLGPEPCIFTSTLPAWNCENLERLASKTCSNLIFAHVRATTEGTLSDTNCHPFQHNTLMWMHNGGIGGWHYIKRALADSLADKWYLGVKGGTDSEWAFALFLDLLAKEGADPSCDPGPEGFGQALLRKVMVKTIAKINEFIKDIPNRHNVPETLETRSLLNFAVTDGHTVVCTRYISSKTDEPASLYFSSGTKWKEGKVKGHFKMERHDKGADIVLVASEPITFERHNWVSVPANSIVTIHKQTVLLHPILDEYYNEDSNHDRSSCYAVSKGLVSTAPGTTVQPQGTDTLPKPDIGISDPGLEPEANGGMPRSQLKATNQCALSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="129" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BEW6</accession>
    <accession>C8VUQ8</accession>
    <name>Q5BEW6_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein phosphatase 2C, putative (AFU_orthologue AFUA_1G15800)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ANIA_00914</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the PP2C family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF88536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_658518.1">
        <property type="nucleotide sequence ID" value="XM_653426.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BEW6"/>
    <dbReference type="STRING" id="227321.Q5BEW6"/>
    <dbReference type="GeneID" id="2876687"/>
    <dbReference type="KEGG" id="ani:ANIA_00914"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN0914"/>
    <dbReference type="eggNOG" id="KOG0698">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021251_2_0_1"/>
    <dbReference type="InParanoid" id="Q5BEW6"/>
    <dbReference type="OMA" id="FKGGSTC"/>
    <dbReference type="OrthoDB" id="416093at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904359">
        <property type="term" value="P:regulation of spore germination"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.40.10:FF:000098">
        <property type="entry name" value="Protein phosphatase 2C, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF589">
        <property type="entry name" value="[PYRUVATE DEHYDROGENASE [ACETYL-TRANSFERRING]]-PHOSPHATASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="6">
        <location>
            <begin position="159"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="58"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="539"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="85"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="542"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBF88536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="560" mass="61980" checksum="77849EE2AA23BDF4" modified="2005-04-26" version="1">MTLAPSKRVTVRVWTLIDSQNYIRFYRCRYSSTTQAAESTRTTKRREFHDYFVTHLPSSSLHPDPRGPLTSFHKLPRSASVPHTGESTHSPTSFQALTSRETTVVRIPLRSAKHHFGAATSRGTRPSNEDTYQAGVIDIPAFAKRPPASLTIRNRSARVAGLRENRGADSASGDPQVFYFGIFDGHGGSECSTFLKETLHEYIQDTAAEFELQSSLRKAGENSASPDAESELPIRQGSNVARVQRLEKSLVQSWRNLVGGYFRRFVPPNFSHLAKHTAEESSSVPENNKGVTIEEILEYAFLRADLDFVSAQASREDDELSNVCRPLYQDDILYGPSRSQSLNIAGLRRFKGGSTASTVLISTPTPAPFWHPASPSSLLVSHVGDTRILLCSTVTGEAIPLTSNHHPSSPIEANRLRRYAATFVTDSFGEERISGLANTRAFGDVQSKRIGVSAEPELRRFEIAPAEYSFLVLMSDGISEALTDQEVVDIIKEAKTPDEGARHVVNFATEVTRTGDNATCLVVRLGGWERRLEGGLGSLGTKESREFRRQEATDPRRSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="117" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BF14</accession>
    <accession>C8VQ04</accession>
    <name>Q5BF14_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hsp70 family protein (AFU_orthologue AFUA_1G15200)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ANIA_00866</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF88630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_658470.1">
        <property type="nucleotide sequence ID" value="XM_653378.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BF14"/>
    <dbReference type="STRING" id="227321.Q5BF14"/>
    <dbReference type="GeneID" id="2876643"/>
    <dbReference type="KEGG" id="ani:ANIA_00866"/>
    <dbReference type="eggNOG" id="KOG0101">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009958_6_2_1"/>
    <dbReference type="InParanoid" id="Q5BF14"/>
    <dbReference type="OMA" id="MGRCTSR"/>
    <dbReference type="OrthoDB" id="2963168at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10170">
        <property type="entry name" value="ASKHA_NBD_HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187">
        <property type="entry name" value="ALPHA KINASE/ELONGATION FACTOR 2 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187:SF79">
        <property type="entry name" value="HSP70 FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_1G15200)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBF88630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="657" mass="73021" checksum="DF9C07D264C4C970" modified="2005-04-26" version="1">MNNPNQLGQPPSYTYNNVAGRPTSPMPPGNQPQMPHPLNTNMPYPGQQTLGAPPVYGMQQPVMGRGLPSSQVPYGARNPAHEVEGAGRSKASLIVGIDFGTTFSGVAFAFATNNEAREDIITEWPGAGTHTKQKIPTVLYYDQYQEVVGWGPDIANALAPTGYPKQGVQKVEWFKLQLMLSGNTYIDPINLPPLPPGKSEIDVAADYLFKLRQAMRSQLQKTLGEVFTREERNIKYYLTVPAIWNDAGKAATRAAALQAGFLRDENDNRLTLISEPEAAALFCAKTGLLNLKVGDAILIVDCGGGTVDLIAYEVEEEQPFSVAECTAGSGDSCGSTALNRNFSNILRAKIRKMKLPDGSRTAGKVYAKCIMDFENRIKADFRNNGQKWAVDVGIEADFPDAGIEEGYMTFTNEEILQCFEPVVNRILELVRNQIIAIQAQNRNLQNVLVVGGFGASEYLFQQIKLHVPPQYQSKVVRPMDSVAAIVKGAVTAGITERVVTHRVARRHYLMATLQPFKEGYHPEQYRVPSLDGRDRCKYTRQIFVQKGERVKIGEPVKVSFFRQVAPGATLMYEDILYACDEDVCPEYTKDPRIKEVVTLTSDLSRKNLETDFERMDTPQGTFYRVYFDIYLTLDGSEFSAELVCQGEVMGRCRAKFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="115" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BFL0</accession>
    <accession>C8VRS6</accession>
    <name>Q5BFL0_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GTP cyclohydrolase II</fullName>
            <ecNumber evidence="3">3.5.4.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">riboB</name>
        <name evidence="11" type="ORF">ANIA_00670</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>GTP + 4 H2O = 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + formate + 2 phosphate + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:23704"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58614"/>
            <dbReference type="EC" id="3.5.4.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; riboflavin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GTP cyclohydrolase II family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.25" evidence="3"/>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF89020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_658274.1">
        <property type="nucleotide sequence ID" value="XM_653182.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BFL0"/>
    <dbReference type="FunCoup" id="Q5BFL0">
        <property type="interactions" value="133"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5BFL0"/>
    <dbReference type="GeneID" id="2876447"/>
    <dbReference type="KEGG" id="ani:ANIA_00670"/>
    <dbReference type="eggNOG" id="KOG1284">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020273_2_4_1"/>
    <dbReference type="InParanoid" id="Q5BFL0"/>
    <dbReference type="OMA" id="RLPNVEC"/>
    <dbReference type="OrthoDB" id="5569761at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019238">
        <property type="term" value="F:cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003935">
        <property type="term" value="F:GTP cyclohydrolase II activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00641">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10990">
        <property type="entry name" value="GTP cyclohydrolase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032677">
        <property type="entry name" value="GTP_cyclohydro_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000926">
        <property type="entry name" value="RibA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036144">
        <property type="entry name" value="RibA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21327">
        <property type="entry name" value="GTP CYCLOHYDROLASE II-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21327:SF29">
        <property type="entry name" value="GTP CYCLOHYDROLASE-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00925">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142695">
        <property type="entry name" value="RibA-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0686">Riboflavin biosynthesis</keyword>
    <feature type="domain" description="GTP cyclohydrolase II" evidence="10">
        <location>
            <begin position="218"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="28"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="183"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="28"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="188"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CBF89020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="385" mass="41408" checksum="07AB00B08B800933" modified="2005-04-26" version="1">MANLPSHASPNFGAQSASIAPPVDDISLTSEQQTSSTSVQPNEFTLGNLPEVGAMGSTPGDLTPGVPASLLSPSFTPPATPGGTLNTERLLQQISPQPVSHAKPPKLLPRLPNVECIVRARIPTTTGAEMFLHLYHNDIDNKEHLAIVFGNTIRSRSLDRVKPGETEMDRMIRGAYIGKLHPGRVSSWHDSTQGSATDRSIEGSEGGAVHNTESMQERLNEAPLVRIHSECYTGETAWSARCDCGEQLDEAARLMSLPMETLNEIASQQSRSVPSNVSGGVIIYLRQEGRGIGLGEKLKAYNLQDLGSDTVEANLLLRHPADARSYGLATAMLVDLGLGKDANPHGIRLLTNNPDKVRAIEGPGREVIVKDRVPMVPLAWQTGDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BGD0</accession>
    <accession>C8VTI6</accession>
    <name>Q5BGD0_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_00400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF89561.1"/>
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        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
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                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
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                <person name="Penalva M.A."/>
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                <person name="Kumagai T."/>
                <person name="Asai K."/>
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                <person name="Denning D.W."/>
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                <person name="Paoletti M."/>
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                <person name="Miller B."/>
                <person name="Dyer P."/>
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            <dbReference type="DOI" id="10.1038/nature04341"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
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        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
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                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
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                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
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            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
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        <scope>GENOME REANNOTATION</scope>
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    </evidence>
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        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
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                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
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                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
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                <person name="Denning D.W."/>
                <person name="Caddick M."/>
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                <person name="Paoletti M."/>
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                <person name="Miller B."/>
                <person name="Dyer P."/>
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            <dbReference type="DOI" id="10.1038/nature04341"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
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                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
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                <person name="Visser J."/>
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        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
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    <dbReference type="HOGENOM" id="CLU_031465_2_0_1"/>
    <dbReference type="InParanoid" id="Q5BGV9"/>
    <dbReference type="OMA" id="VMTYDMM"/>
    <dbReference type="OrthoDB" id="73875at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004568">
        <property type="term" value="F:chitinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000159">
        <property type="entry name" value="Class V chitinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF378">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH18" evidence="3">
        <location>
            <begin position="1"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="350"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBF89945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="370" mass="40618" checksum="5A4D802B29C804BD" modified="2005-04-26" version="1">MYLTGVRQHNVVPEPSLVSDVTHVALAFMQSSIFNRNSTSSWPLFTTVDAVRTEFSNGTSILISIGGWGDTQGFSTAARTDESRKLFAENIRRMVDDTGADGVDIDWEYPGGNGEDYKRIPNSEKFWETAAYPQLLAEIRAAIPDKLITAAVPGLPRDMLAFTKETIPSISASVDFLNVMTYDLMNRRDTVTKHHTGVQLSLESIDAYIEAGMPPEKLNLGLAYYVKWFKTVPGEQCAKQPIGCPTVLMEDPDTGADLGQAGAFSWNDRVPQELAASFEKAKISGEYDPFGGGYYFWDSNENIFWSWDTANAIKRKFPAILEKRKLGGVFAWGLGEDAPEFAHLKATTAGLGDSSAAPGGKLSTSRKDEL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2020-04-22" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1U8QG99</accession>
    <accession>C8VNF2</accession>
    <accession>Q5BAT1</accession>
    <name>ATRC_EMENI</name>
    <protein>
        <recommendedName>
            <fullName>ABC multidrug transporter atrC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">atrC</name>
        <name type="ORF">AN2349</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2000" name="Mol. Gen. Genet." volume="263" first="966" last="977">
            <title>The role of ABC transporters from Aspergillus nidulans in protection against cytotoxic agents and in antibiotic production.</title>
            <authorList>
                <person name="Andrade A.C."/>
                <person name="Van Nistelrooy J.G."/>
                <person name="Peery R.B."/>
                <person name="Skatrud P.L."/>
                <person name="De Waard M.A."/>
            </authorList>
            <dbReference type="PubMed" id="10954082"/>
            <dbReference type="DOI" id="10.1007/PL00008697"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2002" name="Appl. Environ. Microbiol." volume="68" first="1351" last="1357">
            <title>Quantitative analysis of the relative transcript levels of ABC transporter Atr genes in Aspergillus nidulans by real-time reverse transcription-PCR assay.</title>
            <authorList>
                <person name="Semighini C.P."/>
                <person name="Marins M."/>
                <person name="Goldman M.H."/>
                <person name="Goldman G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11872487"/>
            <dbReference type="DOI" id="10.1128/aem.68.3.1351-1357.2002"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Pleiotropic ABC efflux transporter involved in the protection of the cells against a wide range of toxic compounds.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="6 7">Expression is strongly increased in the presence of cycloheximide, imazalil, itraconazole, hygromycin, and 4-nitroquinoline oxide (4-NQO).</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF86663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AACD01000038">
        <property type="protein sequence ID" value="EAA64460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_659953.1">
        <property type="nucleotide sequence ID" value="XM_654861.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1U8QG99"/>
    <dbReference type="SMR" id="A0A1U8QG99"/>
    <dbReference type="FunCoup" id="A0A1U8QG99">
        <property type="interactions" value="755"/>
    </dbReference>
    <dbReference type="GlyCosmos" id="A0A1U8QG99">
        <property type="glycosylation" value="7 sites, No reported glycans"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CBF86663">
        <property type="protein sequence ID" value="CBF86663"/>
        <property type="gene ID" value="ANIA_02349"/>
    </dbReference>
    <dbReference type="KEGG" id="ani:ANIA_02349"/>
    <dbReference type="eggNOG" id="KOG0055">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_17_2_1"/>
    <dbReference type="InParanoid" id="A0A1U8QG99"/>
    <dbReference type="OMA" id="NYDNHKQ"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042626">
        <property type="term" value="F:ATPase-coupled transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd18577">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18578">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03249">
        <property type="entry name" value="ABC_MTABC3_MDL1_MDL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001530">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000057">
        <property type="entry name" value="ABC multidrug transporter SitT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000913">
        <property type="entry name" value="ABC multidrug transporter SitT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF27">
        <property type="entry name" value="ATP-DEPENDENT TRANSLOCASE ABCB1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000449466" description="ABC multidrug transporter atrC">
        <location>
            <begin position="1"/>
            <end position="1284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1 3">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1 3">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1 3">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1 3">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1 3">
        <location>
            <begin position="282"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1 3">
        <location>
            <begin position="320"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1 3">
        <location>
            <begin position="705"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1 3">
        <location>
            <begin position="745"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1 3">
        <location>
            <begin position="824"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1 3">
        <location>
            <begin position="846"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1 3">
        <location>
            <begin position="931"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1 3">
        <location>
            <begin position="955"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1 1" evidence="3">
        <location>
            <begin position="55"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter 1" evidence="2">
        <location>
            <begin position="381"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1 2" evidence="3">
        <location>
            <begin position="705"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter 2" evidence="2">
        <location>
            <begin position="1027"/>
            <end position="1280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="416"/>
            <end position="423"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="1062"/>
            <end position="1069"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="4">
        <location>
            <position position="385"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="4">
        <location>
            <position position="401"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="4">
        <location>
            <position position="488"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="4">
        <location>
            <position position="632"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="4">
        <location>
            <position position="800"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="4">
        <location>
            <position position="995"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="4">
        <location>
            <position position="1122"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="6">
        <source>
            <dbReference type="PubMed" id="10954082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="7">
        <source>
            <dbReference type="PubMed" id="11872487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="8">
        <source>
            <dbReference type="PubMed" id="10954082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="9"/>
    <evidence type="ECO:0000305" key="10">
        <source>
            <dbReference type="PubMed" id="10954082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAA64460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005890"/>
        </source>
    </evidence>
    <sequence length="1284" mass="139551" checksum="6959ACA1986E806A" modified="2017-05-10" version="1">MKSTAESKETPSQDESTTSVPCTEAPLVEEGEEASFGAYKRIFTFAGRTELILQAVAILAACASGAGIALQNLIFGQFVTVITDFTNGISTPADFRDNAAELALYFVYLGIARLVLSYTYNTLLTYAAYRIVRNIRHAYLKAALSQEVAYYDFGSGGSIAAQATSNGKLIQAGASDKIGLLFQGLAAFVTAFIIAFVVQWKLTLICICIPVATIGTTGVVAAVEAGHETRILQIHAQANSFAEGILAGVKAVHAFGMRDSLVRKFDEYLVEAHKVGKKISPLLGLLFSAEYTIIYLGYGLAFWQGIHMFGRGEIGTAGDIFTVLLSVVIASINLTLLAPYSIEFSRAASAAAQLFRLIDRESEINPYGKEGLEPERVLGDVELENVTFSYPTRPGITVLDNFSLKVPAGKVTALVGQSGSGKSTIVGLLERWYNPTSGAIRLDGNLISELNVGWLRRNVRLVQQEPVLFQGSVFDNIRYGLVGTPWENASREEQMERVQEAAKLAYAHEFISELTDGYDTLIGERGGLLSGGQKQRVAIARSVVSQPKVLLLDEATSALDPHAETIVQKALDKAAEGRTTIVIAHKLATIRKADNIVVMSKGHIVEQGTHESLIAKDGVYAGLVKIQNLAVNASAHDNVNEEGEGEDVALLEVTETAVTRYPTSIRGRMNSIKDRDDYENHKHMDMLAALAYLVRECPELKWAYLVVLLGCLGGCAMYPGQAILMSRVVEVFTLSGDAMLDKGDFYASMLIVLAAGCLICYLAVGYATNTIAQHLSHWFRRLILHDMLRQDIQFFDREENTTGALVSRIDSYPHAILELMGYNIALVVIAVLQVVTCGILAIAFSWKLGLVVVFGGIPPLVGAGMVRIRVDSRLDRQTSKKYGTSSSIASEAVNAIRTVSSLAIEETVLRRYTEELDHAVSSSVKPMAATMICFGLTQCIEYWFQALGFWYGCRLVSLGETSMYSFFVAFLSVFFAGQASAQLFQWSTSITKGINATNYIAWLHQLQPTVRETPENHDKGPGSGAPIAMDNVRFSYPLRPDAPILKGVNLKINKGQFIAFVGSSGCGKSTMIAMLERFYDPTTGSITIDASTLTDINPISYRNIVALVQQEPTLFQGTIRDNISLGVFNPNTQPFFSDKDAVKSVSDEQIESALRAANAWDFVSSLPQGIYTPAGSGGSQLSGGQRQRIAIARALIRDPKILLLDEATSALDTESEKIVQKALEGAARDGDRLTVAVAHRLSTIKDANVICVFFGGKIAEMGTHQELIVRGGLYRRMCEAQALD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>C8UZZ1</accession>
    <name>C8UZZ1_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acetyltransferase, GNAT family family (AFU_orthologue AFUA_2G11500)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ANIA_05866</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF70679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467072.1">
        <property type="nucleotide sequence ID" value="XM_050612656.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8UZZ1"/>
    <dbReference type="FunCoup" id="C8UZZ1">
        <property type="interactions" value="238"/>
    </dbReference>
    <dbReference type="STRING" id="227321.C8UZZ1"/>
    <dbReference type="GeneID" id="2871116"/>
    <dbReference type="KEGG" id="ani:ANIA_05866"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN5866"/>
    <dbReference type="eggNOG" id="KOG4144">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061829_1_0_1"/>
    <dbReference type="InParanoid" id="C8UZZ1"/>
    <dbReference type="OMA" id="WLEHAAF"/>
    <dbReference type="OrthoDB" id="30840at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004059">
        <property type="term" value="F:aralkylamine N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000141">
        <property type="entry name" value="Acetyltransferase, GNAT family family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051635">
        <property type="entry name" value="SNAT-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10908">
        <property type="entry name" value="SEROTONIN N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10908:SF0">
        <property type="entry name" value="SEROTONIN N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="4">
        <location>
            <begin position="153"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBF70679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="288" mass="32331" checksum="2C87AE204DF193BC" modified="2009-11-03" version="1">MSDQSYQQPADHPINGLKPLSNADGFSLPITGNDLSHGGYDHSDAIMTNGHPLEETDEDEDEEEVDEDYVAVDHDDLNEYPYWFRRPPVRQPSKLDDLHPFVQVLTQSNVDDCLAVEESFPENERCTREKFIYRLGRCPELCLGLFTLPILGPDQPKPRPTLVGHVIATRTSTPFVTDKSMELPADWETMRSTVVDGETVGHDEYGSTIAIHSLAVLREHQGKQVGSTLMKSYIQRIREAAIADRIVIIAHDNLIPFYEGLGFENRGPSKCQFGGGGWTDMVLEFNTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>C8V0B1</accession>
    <name>C8V0B1_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Tryptophan--tRNA ligase, mitochondrial</fullName>
            <ecNumber evidence="3">6.1.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Tryptophanyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">ANIA_06488</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.2" evidence="3"/>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF70835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467098.1">
        <property type="nucleotide sequence ID" value="XM_050612863.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V0B1"/>
    <dbReference type="FunCoup" id="C8V0B1">
        <property type="interactions" value="390"/>
    </dbReference>
    <dbReference type="STRING" id="227321.C8V0B1"/>
    <dbReference type="GeneID" id="2870236"/>
    <dbReference type="KEGG" id="ani:ANIA_06488"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN6488"/>
    <dbReference type="eggNOG" id="KOG2713">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029244_1_3_1"/>
    <dbReference type="InParanoid" id="C8V0B1"/>
    <dbReference type="OMA" id="GWGQFKP"/>
    <dbReference type="OrthoDB" id="15808at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004830">
        <property type="term" value="F:tryptophan-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070183">
        <property type="term" value="P:mitochondrial tryptophanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00806">
        <property type="entry name" value="TrpRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000082">
        <property type="entry name" value="MSW1p Mitochondrial tryptophanyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.240.10:FF:000002">
        <property type="entry name" value="Tryptophan--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.240.10">
        <property type="entry name" value="Tyrosyl-Transfer RNA Synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002306">
        <property type="entry name" value="Trp-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050203">
        <property type="entry name" value="Trp-tRNA_synthetase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00233">
        <property type="entry name" value="trpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43766">
        <property type="entry name" value="TRYPTOPHAN--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43766:SF1">
        <property type="entry name" value="TRYPTOPHAN--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01039">
        <property type="entry name" value="TRNASYNTHTRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00069760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CBF70835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="384" mass="42755" checksum="9495D41366A51EDD" modified="2009-11-03" version="1">MLIAAKQYSQWLPACRAVKGINHEKWLCAGLGKPSRRLKSSQNAQAPTVFSGIQPTGVPHLGNFLGALREWFKIQEAATENTKLIFSIVDLHALTVPQQSSQLRKWRKEALATLIAVGLDPNRSTIFYQSSVPQHAELFWILSTVASTGYLSRMTQWKSKLQLPEDASLDNSEVRSNLRLGLFSYPVLQAADILVHRATHVPVGEDQRQHLEFARYTANSFNHLYGPIFPSPEALISPAKRVMSLKEPTLKMSKSHADGRSRIILTDSPEDIRRKIKVALTDSEPGITYDPIRRPGISNLIEIFSHLEGKPCSEIASLYQDATPRALKEHLSDKICQILSPIREKFHAVMADGHALSAISEQGAQEARANAEITMKKVRDAMGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>C8V1R3</accession>
    <name>C8V1R3_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7082 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">medA</name>
        <name evidence="3" type="ORF">ANIA_06230</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF69898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_663834.2">
        <property type="nucleotide sequence ID" value="XM_658742.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V1R3"/>
    <dbReference type="STRING" id="227321.C8V1R3"/>
    <dbReference type="GeneID" id="2870796"/>
    <dbReference type="KEGG" id="ani:ANIA_06230"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN6230"/>
    <dbReference type="eggNOG" id="ENOG502QTDM">
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        <property type="component" value="Chromosome I"/>
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    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="AspGD"/>
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        <property type="term" value="P:conidium formation"/>
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        <property type="term" value="P:positive regulation of conidium formation"/>
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        <property type="project" value="AspGD"/>
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            <end position="510"/>
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        </location>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF23305"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="CBF69898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
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    <accession>C8V1U6</accession>
    <name>C8V1U6_EMENI</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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        <name evidence="1" type="ORF">ANIA_11503</name>
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        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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            <taxon>Aspergillus subgen. Nidulantes</taxon>
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    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF69961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_050611678.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V1U6"/>
    <dbReference type="GeneID" id="74897079"/>
    <dbReference type="KEGG" id="ani:ANIA_11503"/>
    <dbReference type="HOGENOM" id="CLU_3351064_0_0_1"/>
    <dbReference type="InParanoid" id="C8V1U6"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF69961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="37" mass="4137" checksum="D25E7EE73299FCCA" modified="2009-11-03" version="1">MVQLFAGQASTPEFIQSGDVRTLDHETRRGTEFARAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>C8V2T9</accession>
    <name>C8V2T9_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter, putative (AFU_orthologue AFUA_2G08910)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ANIA_06063</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF70261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467015.1">
        <property type="nucleotide sequence ID" value="XM_050612080.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V2T9"/>
    <dbReference type="GeneID" id="2871151"/>
    <dbReference type="KEGG" id="ani:ANIA_06063"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN6063"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_13_7_1"/>
    <dbReference type="InParanoid" id="C8V2T9"/>
    <dbReference type="OMA" id="IWTVMIT"/>
    <dbReference type="OrthoDB" id="2533084at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="entry name" value="MFS multidrug transporter, putative"/>
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    </dbReference>
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        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF2">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G08910)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="118"/>
            <end position="137"/>
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    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
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            <begin position="204"/>
            <end position="225"/>
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            <begin position="267"/>
            <end position="293"/>
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            <begin position="313"/>
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    <feature type="transmembrane region" description="Helical" evidence="5">
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            <begin position="386"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="421"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="446"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="50"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBF70261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="479" mass="52838" checksum="A55AC4E9C34A6BA2" modified="2009-11-03" version="1">MHPSRFRNSGLPFIRSPSRVPAPALYGTLDLDPLPSASNEDPYNWPLWKKVINLVLVAFHACMSTFTASIIPAYEDISIDLGVSMQRASYLTSLQIAVLGGAPLFWKPLSNRYGRRPIFLLSTILSLVCNIGCAKSPNYASMAACRALTAFFISPAAAIGSAVVTETFFRKERGRYMGIWTLMVTLGVPVGPLIFGFVTNRAGYRWVFWVLAIINGVQFALYLFFGAETRYISSNQDQSSFISHSLCLPFRRIDPTPLKLSEFYHPLTLVTLPTVFIPAFAYAMVFLFGSVLITVEVPQLLQEKFGLNAEQLGLQFIGVIIGTVLGEQIGGSLSDIWMNRRTRKLQARPEPEFRLWLSYPGVLLTIIGVVVFLVCTQQAAEGHWEVSPIIGTAIAAFGNQVVTTVLVTYAVDSYPQDSGSVGVFVTFVRQIWGFIGPFWFPGMFSNVGIAASSGVAGGLMFVFSFLFIIPVHVFGAKWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>C8V3D0</accession>
    <name>C8V3D0_EMENI</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ANIA_11496</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF70457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467035.1">
        <property type="nucleotide sequence ID" value="XM_050612332.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V3D0"/>
    <dbReference type="GeneID" id="74897072"/>
    <dbReference type="KEGG" id="ani:ANIA_11496"/>
    <dbReference type="HOGENOM" id="CLU_3335557_0_0_1"/>
    <dbReference type="InParanoid" id="C8V3D0"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF70457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="38" mass="3932" checksum="5B6C27E1D966D2A5" modified="2009-11-03" version="1">MSSTRTVRLRSAVESATMEPVTAAGIMYTKAGAGPFQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>C8V4F9</accession>
    <name>C8V4F9_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ANIA_10428</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF75862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467531.1">
        <property type="nucleotide sequence ID" value="XM_050611506.1"/>
    </dbReference>
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        <property type="entry name" value="MFS_dom"/>
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    <dbReference type="PANTHER" id="PTHR43791:SF47">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="177"/>
            <end position="197"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="209"/>
            <end position="232"/>
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    <feature type="transmembrane region" description="Helical" evidence="7">
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            <begin position="284"/>
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    <feature type="transmembrane region" description="Helical" evidence="7">
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            <begin position="348"/>
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    <feature type="transmembrane region" description="Helical" evidence="7">
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            <begin position="374"/>
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    </feature>
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        <location>
            <begin position="407"/>
            <end position="428"/>
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    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="50"/>
            <end position="460"/>
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            <begin position="1"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CBF75862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="491" mass="54279" checksum="31C51517BD29A2CE" modified="2009-11-03" version="1">MAVMAEIKSSSARHVEDNEKGVLSPQVSDSSLQYDEVTVKRIKRKIDVRLCVVVAVMYTVCQIDRVNLANAVVAGMGAEIDLTGTHYSTIVAVFFPTYTVFQPVMTVIARKLGPRIFMGFITMSWGLVMVGMGLVNDWRELARLRVILGLFEAGLFPAAVFLISSWYIRHETGKRIGLFYLLGSAISSFGGILAYGLQQMHGLQGHAGWRWIFIIEGVLTVAIGLAGFVLIVDFPEDARRTRWFLTDREIDIMIDRVEKDRGDAHVTPFVLKEYLKYGLEWQGWLLAVNFLMTAIVIYAVSYFLPIVLMQGLEFNVAEAQTLTAPCFLFGTLLGLTESWLSDKYKTRGIVVVINAALQIMGVALLGYAKNNGVRYFGAFILAGSCNANIPASLTYQSNNITGQWRRAFGSALIVAAGGVGGVIGGLVFRDRDAPDYRYGFILKFSFLGKVVDVPTDPAYGRASLRLRSQLFRWVSQLSLWGGGIGGKRLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>C8V4Q3</accession>
    <name>C8V4Q3_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_10510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF74582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467351.1">
        <property type="nucleotide sequence ID" value="XM_050611312.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V4Q3"/>
    <dbReference type="STRING" id="227321.C8V4Q3"/>
    <dbReference type="GeneID" id="74896447"/>
    <dbReference type="KEGG" id="ani:ANIA_10510"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN10510"/>
    <dbReference type="eggNOG" id="ENOG502S8MB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080764_1_0_1"/>
    <dbReference type="InParanoid" id="C8V4Q3"/>
    <dbReference type="OMA" id="GWIHVSD"/>
    <dbReference type="OrthoDB" id="5397701at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37331">
        <property type="entry name" value="YALI0F11671P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37331:SF1">
        <property type="entry name" value="YALI0F11671P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF74582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="220" mass="23830" checksum="084C2C0A6E72365C" modified="2009-11-03" version="1">MWSFRNIYRQIPRRTQFRSVSTLEGHPHIYVFPSNGTHVLSLLPTEPPSADLAIGVTSKLPPTTDSFRENPKFLETLQEVVAQHGHEDPDAISQAQVMVSTSGANIASGGVLMPGSQTRRRRGGADMTSGASGQGGAGSAGRGGWIHISDSRRPPEYGRIAWPEDIFGSLEVDGDGKFVGGTGNYQASGTYRIVTRDGILGLSPFLREKLIQKLREQEAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>C8V5R0</accession>
    <name>C8V5R0_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_10503</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CoA-transferase III family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF74899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467382.1">
        <property type="nucleotide sequence ID" value="XM_050611346.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V5R0"/>
    <dbReference type="STRING" id="227321.C8V5R0"/>
    <dbReference type="GeneID" id="74896442"/>
    <dbReference type="KEGG" id="ani:ANIA_10503"/>
    <dbReference type="eggNOG" id="KOG3957">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033975_0_1_1"/>
    <dbReference type="InParanoid" id="C8V5R0"/>
    <dbReference type="OMA" id="RVAMYDV"/>
    <dbReference type="OrthoDB" id="5863171at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047369">
        <property type="term" value="F:succinate-hydroxymethylglutarate CoA-transferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="entry name" value="Crotonobetainyl-coa:carnitine coa-transferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="entry name" value="formyl-coa transferase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050483">
        <property type="entry name" value="CoA-transferase_III_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48207">
        <property type="entry name" value="SUCCINATE--HYDROXYMETHYLGLUTARATE COA-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48207:SF3">
        <property type="entry name" value="SUCCINATE--HYDROXYMETHYLGLUTARATE COA-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="CoA-transferase family III (CaiB/BaiF)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF74899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="442" mass="47914" checksum="EF80B4475EE874EC" modified="2009-11-03" version="1">MLLSRAPLRLLKPIGVSIRSLATHAKSKNKKLPLAGLKVLDLSRVLAGPYCTQILGDLGADIIKIEHPVRGDDTRAWGPPYAPYIDGREGPGESAYYLSVNRNKRSLALSFAHPQGQNILHRLVREADILVENYIPNSLAKYKLDYPTLSTINPSLIYTSITGYGQTGPYSNRPGFDVMVEAEFGLAHLTGSKNGPPVKVGVAVTDLTTGLYAVQSILAALWQRAQSKENGEAGKGEGQHLDVCLSDCQVATLANMGQGPLISGQKDSGRWGTAHPSVVPYQSFATADGDIFVGGANDKLFGILCARLNKPEWACDARFVTNSDRVANRSVLEEMIEHETRKLSTKEWQERFQGSGLPFAVVNDVLGTMGHEHVQARGMVQTIAHPACGLIKVISPPVKYSNAEPSIRRAPPLLGEHTDEVLMEIGLSELEIAGLRKEKIVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>C8V7D3</accession>
    <name>C8V7D3_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADH-ubiquinone oxidoreductase 39 kDa subunit, putative (AFU_orthologue AFUA_6G12790)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_10440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF75541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467472.1">
        <property type="nucleotide sequence ID" value="XM_050611443.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V7D3"/>
    <dbReference type="STRING" id="227321.C8V7D3"/>
    <dbReference type="GeneID" id="2873135"/>
    <dbReference type="KEGG" id="ani:ANIA_10440"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN10440"/>
    <dbReference type="eggNOG" id="KOG2865">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_6_4_1"/>
    <dbReference type="InParanoid" id="C8V7D3"/>
    <dbReference type="OMA" id="PEDQFTN"/>
    <dbReference type="OrthoDB" id="275457at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd05271">
        <property type="entry name" value="NDUFA9_like_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000358">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 39 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051207">
        <property type="entry name" value="ComplexI_NDUFA9_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12126:SF11">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12126">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 39 KDA SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="1">
        <location>
            <begin position="59"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF75541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="382" mass="43600" checksum="AD4A0E4D5DAE6773" modified="2009-11-03" version="1">MQKSRAINPVLGSRAFVPNPRIQFQAQRRFLQDITITRTGKPLLKIQGGRHSLGGHTATVFGATGFLGRYIVNKLATQGCTVVVPYREEMAKRHLKVTGDLGRVVFIEYDLRNTQSIEESVRHSDVVYNLVGRDYPTKNFSYTDVHVDGTERIAEAVAKYDVDRFIHVSSYNANKNSPSEFFSTKGWGEEVARSIFPETTIVRPAPLFGFEDRLLHKLASATNLFTANHLQQRSWPVHAIDVGTALERMLHDDTTAGQTFELYGPTNYSLAEIAPLVDREIVKRRRHINVPKRILKPAAYLLNKYLWWPTISADEVEREFIDQEIDPTAKTFKDLGIEPAELSELTFHYLKGYRSSSYYDLPPATERERAEEKKYVHVLDDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>C8V8G7</accession>
    <name>C8V8G7_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_09433</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF77448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_868815.2">
        <property type="nucleotide sequence ID" value="XM_863722.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V8G7"/>
    <dbReference type="GeneID" id="3684026"/>
    <dbReference type="KEGG" id="ani:ANIA_09433"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN9433"/>
    <dbReference type="eggNOG" id="ENOG502SSNK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085155_0_0_1"/>
    <dbReference type="InParanoid" id="C8V8G7"/>
    <dbReference type="OMA" id="SYEREQT"/>
    <dbReference type="OrthoDB" id="5426872at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF77448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="182" mass="19698" checksum="D8037D7747669194" modified="2009-11-03" version="1">MATQDPTPLPPTTILSSKPISQAVAHDFLAAYLDRATTDPALQPNAGISEHGPVSRTTAAAPNIILHNLKRVQAGLAGEVLGRDLAIAEMKEGAQLAQAQSGNDNADGKWEDKAQFEQEQDGNQVYDANVRDEPEGMDVDKVDDTEGKVAATTGTLDKEERKRLKKERRKAEKKAKLKDADE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>C8V9J3</accession>
    <name>C8V9J3_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNA polymerase II transcription elongation factor (Ctr9), putative (AFU_orthologue AFUA_5G05870)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ANIA_11128</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF77911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467777.1">
        <property type="nucleotide sequence ID" value="XM_050611792.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V9J3"/>
    <dbReference type="FunCoup" id="C8V9J3">
        <property type="interactions" value="924"/>
    </dbReference>
    <dbReference type="STRING" id="227321.C8V9J3"/>
    <dbReference type="GeneID" id="74896797"/>
    <dbReference type="KEGG" id="ani:ANIA_11128"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN11128"/>
    <dbReference type="eggNOG" id="KOG2002">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003008_0_1_1"/>
    <dbReference type="InParanoid" id="C8V9J3"/>
    <dbReference type="OMA" id="EHWLTIA"/>
    <dbReference type="OrthoDB" id="343875at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016593">
        <property type="term" value="C:Cdc73/Paf1 complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000250">
        <property type="entry name" value="RNA polymerase II transcription elongation factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000745">
        <property type="entry name" value="RNA polymerase II transcription elongation factor (Ctr9)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:001586">
        <property type="entry name" value="RNA polymerase II transcription elongation factor (Ctr9), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031101">
        <property type="entry name" value="Ctr9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14027">
        <property type="entry name" value="RNA POLYMERASE-ASSOCIATED PROTEIN CTR9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14027:SF2">
        <property type="entry name" value="RNA POLYMERASE-ASSOCIATED PROTEIN CTR9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13174">
        <property type="entry name" value="TPR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="798"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="973"/>
            <end position="999"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBF77911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="1027" mass="115937" checksum="8C813E5C9B51DCF8" modified="2009-11-03" version="1">MTSLRNKYSNGIVNGDSLPVTGVLANSRFSDIPSAIDIPASTLDSEVEVSLEGLPDDPTELCTLLENERAAKNFWVIIALAYAKQKQIDHAIDILNKGLASVAQGATKEKLGLLGWVCWLYLLKSREAPRVVSDVGLGTEARTKDYYIQQATGILNEASRLNPSFPPLFLARGVLSLLRASLHPPRPVRPGAVDNSERVESLRQALKQFDESSKAFGGRNAMAILGRARAHYLLGRYAEALEGYQKVLMRMPGLTDPDPRIGIGCCLWQLGFKEQAKAAWERALALNPDSKVANILLAVYYLYDSSRHATTDPAFGSLYKVAMTQYTQKAFKLDKEYPMTCALFGSYFLLRKAYSTVDTLARKSIENTDVMQIASDGWYLLGRKCHYEGDLAKAAEFYHRSDQARGGGDKGYLPAKFGSVQMQVSNKDYDGAKFQLEKIIQQTKNPECMTLLAALYAEEVFAAQKSGMKEDKSAEAKKAITLFEAVRALWKDESKKITPDESVLVYLSRLYEQNAPDKSMQCLTQLEELQLAEISDEERPEGLEDEEMKAALRVNLPPQLLNNMGCFLYQSSQLNMARSMFQAALDSCARSQEREGELDTDALVTTISYNLGRAFEASDMPDEAKKVYEALLERHSDYTEASARLTYLALRRSPTDEGPKKMAKLYETDSTNLEVRALFGWYLSKSKKRAANIAEDHEQRHHKHTLQYFDKHDRYALTGMGNVHLLFARDMRRDTDQEKEKRRKMYERAVEFFDKALQLDPRNAYAAQGIAIALVDDRKDLSTAVQIFSKIRDSLRDASVYLNLGHVYAELRQYTRSIEHYEAALSKDRARDAQILACLGRVWLLKGKQEMSLAAMKTALDYAQRAHSVAPTQAHLEFNVAFVQNQIASLTYSLPETQRTAQDVQDAADGLRTAVETFGRIAQAKNPPYPAESLEQRANMSKTIIKQLERALQSQKEYEEKNAAKLQQAREAREAEIRRREEEVRKAEEAERERKQRIAEERQRLVEEAQRLALSGQKRNGPAKKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>C8V9N6</accession>
    <name>C8V9N6_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_08802</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF77992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_682071.2">
        <property type="nucleotide sequence ID" value="XM_676979.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V9N6"/>
    <dbReference type="GeneID" id="2868325"/>
    <dbReference type="KEGG" id="ani:ANIA_08802"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN8802"/>
    <dbReference type="HOGENOM" id="CLU_801746_0_0_1"/>
    <dbReference type="InParanoid" id="C8V9N6"/>
    <dbReference type="OMA" id="NINFRFP"/>
    <dbReference type="OrthoDB" id="4510768at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF77992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="346" mass="37078" checksum="211F1FDF70CE3E37" modified="2009-11-03" version="1">MTCTCKSTLPPVSTDLAKGLYHVPPASDNSNTISITQTTTTTTTSIRIVDSDTSSDYDSHSITSADTDTNSVSDYGCGCGFGGDEHNCEDDIEDTNTDSNKISLPARPLPPVPVHRQSPSTSRRSSEVKTKTRLACIEETIPEEEEEVYLAQQRQEGDAKQHRDTTNRRKSMIELFNLSTSLSTSSSSGAASTSSGPGLSLSFSNLSFRFPMPPICGSGNQQCQTEKLDSAGIENPQRENLEHKRPKSMSALSLSYSASSATGSTSASVSPSQLSSTEKSYEKCLDGVPENRAQVHSPATTTTKKQRRMGTILFPPFAFLSRSSVGSALDQDSKGSAVPNGKSLFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C8VA14</accession>
    <name>C8VA14_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ANIA_11108</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDXG' lipolytic enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF78146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467804.1">
        <property type="nucleotide sequence ID" value="XM_050611822.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VA14"/>
    <dbReference type="GeneID" id="74896784"/>
    <dbReference type="KEGG" id="ani:ANIA_11108"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN11108"/>
    <dbReference type="eggNOG" id="ENOG502S9ZP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019364_0_0_1"/>
    <dbReference type="InParanoid" id="C8VA14"/>
    <dbReference type="OMA" id="PAWGAKQ"/>
    <dbReference type="OrthoDB" id="2152029at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033140">
        <property type="entry name" value="Lipase_GDXG_put_SER_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01174">
        <property type="entry name" value="LIPASE_GDXG_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="4">
        <location>
            <begin position="116"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBF78146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="364" mass="40776" checksum="4FF2838EDE8D9ED4" modified="2009-11-03" version="1">MVGPSLLQLPWVALAYARPKHRQDPNWTYRQAFTNSLLKAFLRNWVALHLKWRLSLKPRSESDRFIQIPPANPALYTGIVIDEKIRPETIGATWYPAPYPSPDSSQTALPEGQHVVLHLHGGSYILGDGRTSSCNFLATTLLEHTPSSYILCPQYRLAGNRNGNFPAQLQDTIASYAYLIHTIGIPASQIIISGDSAGADLALALLRYTIEFDNLSILPAPKCCWLWSPWCDVPPAVDPGRWNHSANYRTDYIPGSFPARGAKLFLKNVDVTKYVERYVSPVLHPFAVPSPVLIITGDREVLFEDHKKLSQGLKELAHKDEQIELFVTRGVPHDVLMIAWIMGFQKEARESAIKAGEFVSRLSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C8VAS0</accession>
    <name>C8VAS0_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">UBX domain-containing protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ANIA_04754</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in endoplasmic reticulum-associated protein degradation (ERAD). Acts as a platform to recruit both UBQLN1 and VCP to the ER during ERAD.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Directly interacts with VCP. Interacts with UBQLN1. Forms a complex with VCP and UBQLN1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF76860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467644.1">
        <property type="nucleotide sequence ID" value="XM_050611638.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VAS0"/>
    <dbReference type="FunCoup" id="C8VAS0">
        <property type="interactions" value="111"/>
    </dbReference>
    <dbReference type="STRING" id="227321.C8VAS0"/>
    <dbReference type="GeneID" id="2872546"/>
    <dbReference type="KEGG" id="ani:ANIA_04754"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN4754"/>
    <dbReference type="eggNOG" id="KOG2507">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035996_1_1_1"/>
    <dbReference type="InParanoid" id="C8VAS0"/>
    <dbReference type="OMA" id="FEPNNTS"/>
    <dbReference type="OrthoDB" id="2445133at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006986">
        <property type="term" value="P:response to unfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01767">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46424">
        <property type="entry name" value="UBX DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46424:SF1">
        <property type="entry name" value="UBX DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23187">
        <property type="entry name" value="UBX7_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0834">Unfolded protein response</keyword>
    <feature type="domain" description="UBX" evidence="7">
        <location>
            <begin position="262"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="113"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="386"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="121"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="160"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="211"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="242"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="386"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="426"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00041575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00046062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBF76860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="447" mass="48796" checksum="83280943FB814425" modified="2009-11-03" version="1">MFFTGTLQEGITLAVQESKAVVCFVPDNGETSSTWQEEYFQGDEEFTRLLGSQSVLLRIAKDSQEAGFLASVCPISKYPTVVIIRNGMLREYIVPDISKEGFRNRVMAAIADSKPQSQTISSSVPQQSAQQAQELSSPAARAPQTVTTAPTPAVDTTRASITQGQSSQNVSTRSSGGRANDITYSSGSRMYSATVPRKQEREYDTPQSSNKAKETTEQKNDDMKGKAPIRTNKDEKSKNQKSAAASPAPHSTSVPVPPSQYRLQVRLFDGSSVRSTFSPLHTIRSDVRPWLDNQLEEKRPYNLKLIMTPLPNKTLTIAEEDQTLSELISGSTATFVMVPIKAYTEAYSDSGSLPVRAVSSAYGLVTSVVGGAVGYIGSFIGYSPNRASSSESAPPQSREFQASADATRRPRQWGANIRTLGDQRDGQNSQFYNGNQLNFEPRQGDDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>C8VAY5</accession>
    <name>C8VAY5_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_10588</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF76987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467664.1">
        <property type="nucleotide sequence ID" value="XM_050611661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VAY5"/>
    <dbReference type="GeneID" id="74896488"/>
    <dbReference type="KEGG" id="ani:ANIA_10588"/>
    <dbReference type="eggNOG" id="ENOG502SARD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096567_2_0_1"/>
    <dbReference type="InParanoid" id="C8VAY5"/>
    <dbReference type="OMA" id="KMYIGVH"/>
    <dbReference type="OrthoDB" id="5363290at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42083">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42083:SF1">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF76987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="183" mass="20518" checksum="19A76147ED1C6AE6" modified="2009-11-03" version="1">MSKRAKIKALLSTALAVVQFAFGLAVIGLYSQDINTARDNGDSAPSRWVYAVVTAFLSTVTAFLYLVLGWWWKKRSKPSFSQRAGLFLPLFAWESVLVILWLVVFGIFGEMYIGVYHVGGKDGGESKVTRMRRAVWVDLACLVLWVLSGAWRGVRWWKAKGMGQGVGFFRRRADVESGEKEMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>C8VB27</accession>
    <name>C8VB27_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Conserved serine proline-rich protein (AFU_orthologue AFUA_2G01790)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_04650</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF77067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467675.1">
        <property type="nucleotide sequence ID" value="XM_050611672.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VB27"/>
    <dbReference type="STRING" id="227321.C8VB27"/>
    <dbReference type="GeneID" id="2872443"/>
    <dbReference type="KEGG" id="ani:ANIA_04650"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN4650"/>
    <dbReference type="eggNOG" id="ENOG502RDJ2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008050_0_0_1"/>
    <dbReference type="InParanoid" id="C8VB27"/>
    <dbReference type="OMA" id="RIEMTYY"/>
    <dbReference type="OrthoDB" id="270970at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="CDD" id="cd08681">
        <property type="entry name" value="C2_fungal_Inn1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037791">
        <property type="entry name" value="C2_fungal_Inn1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052981">
        <property type="entry name" value="Ingression_C2_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47052">
        <property type="entry name" value="CONSERVED SERINE PROLINE-RICH PROTEIN (AFU_ORTHOLOGUE AFUA_2G01790)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47052:SF3">
        <property type="entry name" value="INGRESSION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="2">
        <location>
            <begin position="9"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="169"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="390"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="526"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="542"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="604"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="658"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="727"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="749"/>
            <end position="760"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF77067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="811" mass="89107" checksum="160BADA9EAD80CFF" modified="2009-11-03" version="1">MALRMSGINHAAGIFADMSVDGPAIGTLVAVVDRAKNLPNRKTMGKQNPYCAARLGKEAQKTGTDVRGGQTPKWDQELRFTVHESPDYFRMKLSVFNDDKRTDLIGETWIDLQNLIIPGGSQSDQWHTLQFRGKYAGEIRLEMTYYDTRPEDEAVIERRTQGTERAKTSGSSRSGPVAVVPSPAPSSSSSSSLSGPRQLKEVKRRPLPSDHSSGPRPAPEKAYSSPAPLPVSHPPRAPYDGVPTPPSSSGMDYAHQPRHTAAPVIYDAPPRPRTYETPDDFGREWNAPPHHPPAGRGQPHYSEYYPTRAEQDYYARPRSGYENAPPADYRSMRQMPAGRQDPYYEDMHAEATRPSSRHYNQHPPDAYTYGPEELQPARYHHASSSMSSRHRIEYPQESEPYRQHNSLPRRGRSPSRYHAEYASMQPRVEDEDEEGAPPPPPVHRTAMAHPSPQLVPSPAPSYKAYSPEYGPRSTQDMKLPQPTELMLDPPPVTSTSMPPSLVAGLDPVVAEAESERFAREIRRRSGVLEEHLPGPNRSRDPSPSPISPPYPDNLPAEDHHRSLVSRRSVIAEAPSQQLVLRKSVSPRPPPSRGRGGSQPSVSQTPFSPDSFDSFNPNAARSVMNRDPAPAYTTPAEAMEAARRSEAAAARPEGPIIGDDGREIDPSDHLPTDTWAPEPDRKSRKPGVIVRFRNAPTRHSPAAPRPTSSYVSTSDGDRGRPGYGSNSGHGRTYSTPSSNPMPRRHSISPSPSPMYAPAPVGPPIPAKVPIGAPTGVQDALSRELNSIDIGSVGFSSSRAMRKYVPRPTGYAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>C8VCP2</accession>
    <name>C8VCP2_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">tRNA nucleotidyltransferase (AFU_orthologue AFUA_2G16660)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ANIA_10924</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF78640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467854.1">
        <property type="nucleotide sequence ID" value="XM_050611876.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VCP2"/>
    <dbReference type="FunCoup" id="C8VCP2">
        <property type="interactions" value="116"/>
    </dbReference>
    <dbReference type="STRING" id="227321.C8VCP2"/>
    <dbReference type="GeneID" id="74896682"/>
    <dbReference type="KEGG" id="ani:ANIA_10924"/>
    <dbReference type="eggNOG" id="KOG2159">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019592_2_0_1"/>
    <dbReference type="InParanoid" id="C8VCP2"/>
    <dbReference type="OMA" id="WQKFLDH"/>
    <dbReference type="OrthoDB" id="445712at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052929">
        <property type="term" value="F:ATP:3'-cytidine-cytidine-tRNA adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052927">
        <property type="term" value="F:CC tRNA cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004810">
        <property type="term" value="F:CCA tRNA nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001680">
        <property type="term" value="P:tRNA 3'-terminal CCA addition"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd05398">
        <property type="entry name" value="NT_ClassII-CCAase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3090.10:FF:000011">
        <property type="entry name" value="tRNA nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.10:FF:000019">
        <property type="entry name" value="tRNA nucleotidyltransferase cca2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3090.10">
        <property type="entry name" value="cca-adding enzyme, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002646">
        <property type="entry name" value="PolA_pol_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032828">
        <property type="entry name" value="PolyA_RNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13734:SF5">
        <property type="entry name" value="CCA TRNA NUCLEOTIDYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13734">
        <property type="entry name" value="TRNA-NUCLEOTIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01743">
        <property type="entry name" value="PolyA_pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12627">
        <property type="entry name" value="PolyA_pol_RNAbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81891">
        <property type="entry name" value="Poly A polymerase C-terminal region-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Poly A polymerase head" evidence="6">
        <location>
            <begin position="132"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA nucleotidyltransferase/poly(A) polymerase RNA and SrmB- binding" evidence="7">
        <location>
            <begin position="307"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBF78640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="605" mass="68945" checksum="11FE422CC8A6A9F7" modified="2009-11-03" version="1">MFAYSCSSCAIRVFTRLTQRTTYFPRSPSFHQPTSHRIPIQLALFSCYMSRHQLGDFPSPRAKKRRRISTTTAAEAGVATMNPAADGTSQQLPTIQLTPCETTLKDLLLDVAQYIQDCDTANRHGDGTKTVLRFTGGWVRDKLLGVESHDIDVAINNMTGYQFGTMLKEYLDIPENLDKYKGQNGEKELSLHKIEANPEKSKHLETVTTKIFGFDVDLVNLRKEAYDENSRTPQMEFGTAEEDALRRDATINALFYNLNESKVEDLTGRGLDDMRDEIIRTPMEPYQTFKDDPLRVLRLIRFASRLGFRIDKDTENAMQHGDIGAALKLKISRERVGIEVQKMLQGPDPRGALHIIDRLNLYPIIFANFQDDVTADYSTWSLAYEALHRLCSEDDSGTISRVRSLLVRDPLETYYSWVIVAFAPWSTVPTRVQGTKLIPPRMAETARDSLRADNRTVNILKQTGTHWRNIIDVKTALVEGRMEGTAAEVRQQLGLHIRSWSTDWRFCVLLSLLQEIMQGGNFVKVVQSYDQFLSYIVEQDLQDVCDLKHIVKGDEIMEAFETRKKGPWVSNALKLVIEWQLLHPGVEDKEGALKYLQSKREEIGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>C8VDK0</accession>
    <name>C8VDK0_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ANIA_07734</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF80000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468033.1">
        <property type="nucleotide sequence ID" value="XM_050612075.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VDK0"/>
    <dbReference type="STRING" id="227321.C8VDK0"/>
    <dbReference type="GeneID" id="2869706"/>
    <dbReference type="KEGG" id="ani:ANIA_07734"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN7734"/>
    <dbReference type="eggNOG" id="KOG1318">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046871_3_0_1"/>
    <dbReference type="InParanoid" id="C8VDK0"/>
    <dbReference type="OMA" id="KMVPGCE"/>
    <dbReference type="OrthoDB" id="71302at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11398">
        <property type="entry name" value="bHLHzip_scCBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000088">
        <property type="entry name" value="HLH DNA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
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            <begin position="32"/>
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        <name evidence="1" type="ORF">ANIA_11576</name>
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            <taxon>Eurotiomycetidae</taxon>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
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            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
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                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
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            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
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        <source>
            <dbReference type="EMBL" id="CBF80234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="25" mass="3023" checksum="96B5AB4BDAF56BB4" modified="2009-11-03" version="1">MLLLRIYFVRADQPVNQKDMDVTQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>C8VE39</accession>
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            <fullName evidence="1">FAD/NAD(P)-binding domain-containing protein</fullName>
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    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
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                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
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                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
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            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF80354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_676523.2"/>
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    <dbReference type="STRING" id="227321.C8VE39"/>
    <dbReference type="GeneID" id="2868821"/>
    <dbReference type="KEGG" id="ani:ANIA_08346"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN8346"/>
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    <dbReference type="HOGENOM" id="CLU_030742_2_2_1"/>
    <dbReference type="InParanoid" id="C8VE39"/>
    <dbReference type="OMA" id="ERYSMFI"/>
    <dbReference type="OrthoDB" id="5376590at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
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    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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        <property type="project" value="GO_Central"/>
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        <property type="entry name" value="Sulphide_quinone_reductase"/>
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        <property type="entry name" value="SULFIDE:QUINONE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SULFIDE:QUINONE OXIDOREDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="1">
        <location>
            <begin position="33"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF80354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="442" mass="47997" checksum="980A12E6C06FA33D" modified="2009-11-03" version="1">MFRSQVASAARAVATHRGFATASPVAATARNHKVVVIGGGTAGLAISHQLLRSGRFVKDDIAIVDPAIWHNYQPGWTLVGGGLKTREQLRQPLAGLMDPKLKFYNESVGSFAPEENYITLGNSDKLNYDHLVVAPGIALNFGSVQGLSEALAAPDSKVSTIYSYDTCSKVFPTIEKLKKGQAIFTQPAGVIKCAGAPQKIMWLALDYWKKAGLYDPSNPAGSAIKIAFATGTPSMFGVPKYNAKLEELRKERGVEGLFQHDLVAIDGKKATFARPNGESSVTREFDLLHVVPKMGPHAFVKNSALANEAGYVDVDDGTTRHKKFANVWSAGDASSLPTSKTAAAITAEAPVLVQNLLRSMDGKEIDATYDGYTSCPLTTEYGKVLLAEFKYGGVPKETFGKWFGIDQGTPRKEFYFLKKHFFPWVYYESMVSGKWGGPKGWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>C8VEK4</accession>
    <name>C8VEK4_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_11616</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF80658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468106.1">
        <property type="nucleotide sequence ID" value="XM_050612157.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VEK4"/>
    <dbReference type="STRING" id="227321.C8VEK4"/>
    <dbReference type="GeneID" id="74897177"/>
    <dbReference type="KEGG" id="ani:ANIA_11616"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN11616"/>
    <dbReference type="HOGENOM" id="CLU_3014135_0_0_1"/>
    <dbReference type="InParanoid" id="C8VEK4"/>
    <dbReference type="OrthoDB" id="5371334at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002993386" evidence="1">
        <location>
            <begin position="19"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF80658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="56" mass="6114" checksum="4E1B359990404531" modified="2009-11-03" version="1">MRLTIWLGLSFKLSLPNGATVAGIRNIPTDSPSPHYRPLIVGLHGGTYDCHYFDGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>C8VFX0</accession>
    <name>C8VFX0_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter, putative (AFU_orthologue AFUA_4G11060)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ANIA_05628</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF81521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_663232.2">
        <property type="nucleotide sequence ID" value="XM_658140.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VFX0"/>
    <dbReference type="FunCoup" id="C8VFX0">
        <property type="interactions" value="77"/>
    </dbReference>
    <dbReference type="GeneID" id="2871919"/>
    <dbReference type="KEGG" id="ani:ANIA_05628"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN5628"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_8_4_1"/>
    <dbReference type="InParanoid" id="C8VFX0"/>
    <dbReference type="OMA" id="NWNYRRR"/>
    <dbReference type="OrthoDB" id="2441642at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000009">
        <property type="entry name" value="MFS multidrug transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF150">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
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    <sequence length="592" mass="64208" checksum="F481CE27951B74E1" modified="2009-11-03" version="1">MASERSGYHQHHDRACPSIEIDEILPTDETVITPTTTSSLCQCSSSALSNASLRATAPPAEGSAMPTLMPTTTMGPRRYSAFSNSQKRFIVAMVTLASFFSPLSGQIYYPVMPTLVENYHLSNALINLTITTYMILQGVAPAFMGTFADACGRRPAYFFAFAIYTAANIGLALQDSYPALMVLRCIQSAGSSGTVSFGYGVIADIATPAERGSYVGPMAAGVMLAPALGPIIGGLLAKFLGWRSVFWFLAIGAGGYLVSYVFFVPETARTVVGDGRLFPRERWRWSAAQWLQRKWKSASGSGFNDDHGAHFEAATMQSAFNGSGQASTTSRLRFPNPLRALYILLEPDALIIVSSIGLLMLTNVALLTSTPSLFSKIYGFNDLQIGLCFLPLGIGAALGAVLNGYFLNRSYRRHAQSLDLPLDPSIATTLQDFPIEQSRLEIYFPLIILTILTLVPYGFVLERRANLSAPLILQFLNGFGTVACTNTLNTLLVDLFPDEPATAAAACNLVRCWLGALGAAVVDYMLSGMGWGWCFMFLGLLLLASIGLAWSEFVYGAKWRGSRRLRRERECESGRETIEIAEGEGDRRSGKG</sequence>
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<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>C8VH40</accession>
    <name>C8VH40_EMENI</name>
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            <fullName evidence="1">Uncharacterized protein</fullName>
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        <name evidence="1" type="ORF">ANIA_05250</name>
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        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
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            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
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        </citation>
        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
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        <property type="nucleotide sequence ID" value="XM_050612378.1"/>
    </dbReference>
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        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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        <property type="component" value="Chromosome V"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF82244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="376" mass="41661" checksum="806AE6A6DFB65A81" modified="2009-11-03" version="1">MRELTRHTDSRTAYQLSLLKLGFSGDEAKDVSLAPVFTGPVLYTQPNLVPSQYGLLAGVLELRALGSPDLDSQAYGEDPRLFFNHTLSCLLEGCLIPSAAGQLHNPLTAVVFHYDTFIGDQGGSPCEAAFLATSPKCPSEGSLCPQQISEIFRFKIRVHPLQINQQDLNTKRMLDLMTAGQGSSSGPLYLHTVQRVLREMRLLQQVSGGRFDYQDFKKRIFDSDLLPSQQQPLRQRLDILESFMPSQQIIASTSKKGKKAVNDAGTSWSPKTGCGISSWVAANRKTLSDSAKACAVLKAVSHLQDFLTTTILLSPFFFSDSFFMRRPFTMIMEEESRTTGCTELTAKKPSTSYYYSYICNAYPLQTKLSLSLSPGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>C8VI99</accession>
    <name>C8VI99_EMENI</name>
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            <fullName evidence="2">DUF6536 domain-containing protein</fullName>
        </recommendedName>
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    <gene>
        <name evidence="3" type="ORF">ANIA_10386</name>
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        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
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        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
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                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
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            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF83182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_050612521.1"/>
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    <dbReference type="AlphaFoldDB" id="C8VI99"/>
    <dbReference type="GeneID" id="74896377"/>
    <dbReference type="KEGG" id="ani:ANIA_10386"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN10386"/>
    <dbReference type="eggNOG" id="ENOG502RYAY">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_010112_0_1_1"/>
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    <dbReference type="OMA" id="DPYRWIC"/>
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    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046623">
        <property type="entry name" value="DUF6536"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35395">
        <property type="entry name" value="DUF6536 DOMAIN-CONTAINING PROTEIN"/>
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            <dbReference type="Pfam" id="PF20163"/>
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    </evidence>
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    <accession>C8VK44</accession>
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            <taxon>Eurotiomycetidae</taxon>
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        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
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            <dbReference type="DOI" id="10.1038/nature04341"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
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    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
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                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
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                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
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        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
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        <source>
            <dbReference type="EMBL" id="CBF82440.1"/>
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        <source>
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    <accession>C8VL27</accession>
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        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
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            <dbReference type="DOI" id="10.1038/nature04341"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
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    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
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                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
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            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
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        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
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    <feature type="region of interest" description="Disordered" evidence="1">
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF85890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="467" mass="50030" checksum="D034344CB375ACC2" modified="2009-11-03" version="1">MCFSMSSSLRPQFFCTRPNGTLTPLIAVDELPAHITIHGAPRVLSPNETQGMTSLGAVSTRGQFYSVEGAAPANGKNQPGSNDLQSHLLRLLNDENIPAAQRNALGALLQQSLPQSWQVTNPPTNGWLISNNGSNSGAGNSQQVGCLYKHEMPHDRAMLEKLGLRDIPRWYRDKYNIPSLLPNGHGHPRSNPANGNEMSLRSIQYTPQMGAYGAGEHSDINESVKQDAPAYTPQQHQHGVLLPGTPFSPLASPTGPFTPRQAPRSSSGHLNAGNRKFDPLPFDHAAFIPNNNPPYRPSNEASYEALGKYQHENVVQNFPSLTLNPITTNTDYLPATFDSPVSSGGFKHSLRSRRLYQGTHDVEPSSSQDLIEANTLHAYHNQATASSNGASPTSKTTGSAVASPVADIGRRSTNSNPPTRGPSPSASSPGASPGVFRGRGRNNRGQAKAFGTIGTKRSNGKQSVESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>C8VLJ5</accession>
    <name>C8VLJ5_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fatty acid hydroxylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_12277</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF84662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468603.1">
        <property type="nucleotide sequence ID" value="XM_050612717.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VLJ5"/>
    <dbReference type="GeneID" id="74897220"/>
    <dbReference type="KEGG" id="ani:ANIA_12277"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN12277"/>
    <dbReference type="eggNOG" id="ENOG502SJ0Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058483_0_0_1"/>
    <dbReference type="InParanoid" id="C8VLJ5"/>
    <dbReference type="OMA" id="WIRRGAY"/>
    <dbReference type="OrthoDB" id="4350666at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="69"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="398"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF84662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="423" mass="48202" checksum="185A503696BEA153" modified="2009-11-03" version="1">MPLLFSFFLFVYLYISSSLFFDIVHFCLHQWSSSRYEALRWLSRCHQFHHLYYNRSLNFNSRYRWQNSWFALPLEAACLCIGGLLGWFFLMLLPVIEQKHVLRTPLIAILAVHIIRTSVVIYMSGQDSNHVVYKTVPKDPSWLFVGPQFHALHHVHPDRYMGSVVKVFDWLAGTAYSLRNKSVVITGGSGALGSAIIRRLRSEGVRNVYSLKFGEHWTHGDFNRVGPIFDHLEPDILILAHGTKGEDAMDANCNSTIRLIQLYLEQRAGRTPASATKTLPEVWYIGSEVELHPAFGGAEMYRYLDSKRAFLPYARALYDDSGVVYRHIVPAAFQSRMGRAIVSADWAAGVMMWWIRRGARYVPVTYTGFAYSNFFKFFCSRNTIDGVPVDSARVRPDRSGIGVGRQRHGASSSSDVCRINPAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>C8VMP9</accession>
    <name>C8VMP9_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">2-hydroxyacyl-CoA lyase</fullName>
            <ecNumber evidence="12">4.1.2.63</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">ANIA_10214</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="20">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes a carbon-carbon cleavage reaction; cleaves a 2-hydroxy-3-methylacyl-CoA into formyl-CoA and a 2-methyl-branched fatty aldehyde.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a 2-hydroxy-3-methyl fatty acyl-CoA = a 2-methyl-branched fatty aldehyde + formyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:25375"/>
            <dbReference type="ChEBI" id="CHEBI:49188"/>
            <dbReference type="ChEBI" id="CHEBI:57376"/>
            <dbReference type="ChEBI" id="CHEBI:58783"/>
            <dbReference type="EC" id="4.1.2.63"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:25376"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>an (R)-2-hydroxy-long-chain-fatty acyl-CoA = a long-chain fatty aldehyde + formyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:67444"/>
            <dbReference type="ChEBI" id="CHEBI:17176"/>
            <dbReference type="ChEBI" id="CHEBI:57376"/>
            <dbReference type="ChEBI" id="CHEBI:170012"/>
            <dbReference type="EC" id="4.1.2.63"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:67445"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Peroxisome matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the TPP enzyme family.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.63" evidence="12"/>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF85026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468667.1">
        <property type="nucleotide sequence ID" value="XM_050612789.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VMP9"/>
    <dbReference type="FunCoup" id="C8VMP9">
        <property type="interactions" value="405"/>
    </dbReference>
    <dbReference type="STRING" id="227321.C8VMP9"/>
    <dbReference type="GeneID" id="74896275"/>
    <dbReference type="KEGG" id="ani:ANIA_10214"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN10214"/>
    <dbReference type="eggNOG" id="KOG1185">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013748_3_3_1"/>
    <dbReference type="InParanoid" id="C8VMP9"/>
    <dbReference type="OMA" id="PGPYGCL"/>
    <dbReference type="OrthoDB" id="10006023at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106359">
        <property type="term" value="F:2-hydroxyacyl-CoA lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001561">
        <property type="term" value="P:fatty acid alpha-oxidation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd02004">
        <property type="entry name" value="TPP_BZL_OCoD_HPCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07035">
        <property type="entry name" value="TPP_PYR_POX_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1220:FF:000006">
        <property type="entry name" value="2-hydroxyacyl-CoA lyase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000071">
        <property type="entry name" value="2-hydroxyphytanoyl-CoA lyase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000054">
        <property type="entry name" value="Putative 2-hydroxyphytanoyl-CoA lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045025">
        <property type="entry name" value="HACL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme_TPP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43710">
        <property type="entry name" value="2-HYDROXYACYL-COA LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43710:SF2">
        <property type="entry name" value="2-HYDROXYACYL-COA LYASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 19" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 15" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Thiamine pyrophosphate enzyme N-terminal TPP-binding" evidence="18">
        <location>
            <begin position="4"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme central" evidence="16">
        <location>
            <begin position="198"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme TPP-binding" evidence="17">
        <location>
            <begin position="400"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00059692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00070390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CBF85026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="605" mass="64769" checksum="793B91951520DE83" modified="2009-11-03" version="1">MAIRTGAQIIARSLRDLGVTVIFGIVGIPVVEIAEEAINLGIRFVAFRNEQACSYAASVYGYMTGQPGVCLVVGGPGVLHALAGIGNSSANNFPLLVLAGSAETSAVTKGAFQELDAISLLTPHTKFAARASSLDFIPDAIKNAYRTCWYGRPGPTFIDLPADIIQGKLTSQFELPKPENLLVSAPPKASGDPALILKATQLLKAASAPLIIVGKGAAYARAELGIRKLVDQTQVPFLPTPMGKGVVPDSHPLNASSARSAALKHADVVLVLGARLNWILHFGEPPKWSPKVKIIQVDICAEEIGRNAGTSELGILGDISLVVDQFRASLSSWKYSSSAKFPLLLAESAKKNEDKAQKAALRQTPAGKPLTYQRAYHIIKTALNALTPVEDGNIVYVSEGANTMDISRSIFPLYHPRQRLDAGTYATMGVGMGYIVAAHEAFNANPGASTSRPKKIVAFEGDSAFGFSAMEIETLARYRIPALIFVINNSGIYHGDSISKEDWKTLQNQTVANDTKTSESDSGTNAKTKGLRSTSLLYETRYEMLATMCGGKGYFVKSEEELERATKEGFVSDTVTIVNVIVEPGIGKEIGFAWQNQGKESKPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>C8VNR6</accession>
    <name>C8VNR6_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_11337</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF86783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468881.1">
        <property type="nucleotide sequence ID" value="XM_050613039.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VNR6"/>
    <dbReference type="GeneID" id="74896938"/>
    <dbReference type="KEGG" id="ani:ANIA_11337"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN11337"/>
    <dbReference type="HOGENOM" id="CLU_2346671_0_0_1"/>
    <dbReference type="InParanoid" id="C8VNR6"/>
    <dbReference type="OMA" id="TMKGGQP"/>
    <dbReference type="OrthoDB" id="4480828at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF86783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="97" mass="9965" checksum="B47430FDB7FE7CFD" modified="2009-11-03" version="1">MPPATMNIGKSAGRSPASSSRNIAFMTIAGVIGGAYALFRLQSPSKGVVKEDDIADATETPKYGRSKILGEGDTAAAMGNPPQGHGHVGRSPRKGLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>C8VNW7</accession>
    <name>C8VNW7_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HET domain protein (AFU_orthologue AFUA_8G07340)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_01717</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF85425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468718.1">
        <property type="nucleotide sequence ID" value="XM_050612848.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VNW7"/>
    <dbReference type="GeneID" id="2875717"/>
    <dbReference type="KEGG" id="ani:ANIA_01717"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN1717"/>
    <dbReference type="eggNOG" id="ENOG502SIYG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_799326_0_0_1"/>
    <dbReference type="InParanoid" id="C8VNW7"/>
    <dbReference type="OrthoDB" id="5135333at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF1">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="295"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF85425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="347" mass="39257" checksum="2C4354092EF8AE9D" modified="2009-11-03" version="1">MECAAIRKTTSGSKKVKVTGWDIQPGIGKDACTQFEVILSDGSQAKDPPWSTRCRCRSHSLYSTVLEGCEAHYPRSRFRGYCEWDLRLVDHKLHIVLRAVDGVEWSTSLESDSNQLIVPAQQAQLAELFIALCVACQNRFGAAALQLRAESPGPHVFAAPFCEVGGLPCRDRDDTCFELCRASDQSWSILSPDNILWWTREITQEAPQRKHPKPANWGGIQDARRNYKSLKESKKRASMLPPVDLTEAPRVHGSVMKFAQSGKPNGNTINPLRLIHVQTRDMIATAELETKRYAAISYTWSQVSKAKLLESATTRAKELGYEYIWIDQYCIDQTNRQERNAEIKRMR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2016-06-08" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>C8VQ92</accession>
    <name>AUSJ_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Austinoid biosynthesis clusters protein J</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ausJ</name>
        <name type="ORF">ANIA_11214</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2012" name="ACS Chem. Biol." volume="7" first="599" last="606">
            <title>Signaling the induction of sporulation involves the interaction of two secondary metabolites in Aspergillus nidulans.</title>
            <authorList>
                <person name="Rodriguez-Urra A.B."/>
                <person name="Jimenez C."/>
                <person name="Nieto M.I."/>
                <person name="Rodriguez J."/>
                <person name="Hayashi H."/>
                <person name="Ugalde U."/>
            </authorList>
            <dbReference type="PubMed" id="22234162"/>
            <dbReference type="DOI" id="10.1021/cb200455u"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2012" name="J. Am. Chem. Soc." volume="134" first="4709" last="4720">
            <title>Two separate gene clusters encode the biosynthetic pathway for the meroterpenoids austinol and dehydroaustinol in Aspergillus nidulans.</title>
            <authorList>
                <person name="Lo H.C."/>
                <person name="Entwistle R."/>
                <person name="Guo C.J."/>
                <person name="Ahuja M."/>
                <person name="Szewczyk E."/>
                <person name="Hung J.H."/>
                <person name="Chiang Y.M."/>
                <person name="Oakley B.R."/>
                <person name="Wang C.C."/>
            </authorList>
            <dbReference type="PubMed" id="22329759"/>
            <dbReference type="DOI" id="10.1021/ja209809t"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2013" name="J. Am. Chem. Soc." volume="135" first="10962" last="10965">
            <title>Spiro-ring formation is catalyzed by a multifunctional dioxygenase in austinol biosynthesis.</title>
            <authorList>
                <person name="Matsuda Y."/>
                <person name="Awakawa T."/>
                <person name="Wakimoto T."/>
                <person name="Abe I."/>
            </authorList>
            <dbReference type="PubMed" id="23865690"/>
            <dbReference type="DOI" id="10.1021/ja405518u"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2017" name="ACS Chem. Biol." volume="12" first="2927" last="2933">
            <title>Rewiring of the austinoid biosynthetic pathway in filamentous fungi.</title>
            <authorList>
                <person name="Mattern D.J."/>
                <person name="Valiante V."/>
                <person name="Horn F."/>
                <person name="Petzke L."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="29076725"/>
            <dbReference type="DOI" id="10.1021/acschembio.7b00814"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="2 3 4 5">Part of the gene cluster B that mediates the biosynthesis of austinol and dehydroaustinol, two fungal meroterpenoids (PubMed:22329759). The first step of the pathway is the synthesis of 3,5-dimethylorsellinic acid by the polyketide synthase ausA (PubMed:22329759). 3,5-dimethylorsellinic acid is then prenylated by the polyprenyl transferase ausN (PubMed:22329759). Further epoxidation by the FAD-dependent monooxygenase ausM and cyclization by the probable terpene cyclase ausL lead to the formation of protoaustinoid A (PubMed:22329759). Protoaustinoid A is then oxidized to spiro-lactone preaustinoid A3 by the combined action of the FAD-binding monooxygenases ausB and ausC, and the dioxygenase ausE (PubMed:22329759, PubMed:23865690). Acid-catalyzed keto-rearrangement and ring contraction of the tetraketide portion of preaustinoid A3 by ausJ lead to the formation of preaustinoid A4 (PubMed:22329759). The aldo-keto reductase ausK, with the help of ausH, is involved in the next step by transforming preaustinoid A4 into isoaustinone which is in turn hydroxylated by the P450 monooxygenase ausI to form austinolide (PubMed:22329759). Finally, the cytochrome P450 monooxygenase ausG modifies austinolide to austinol (PubMed:22329759). Austinol can be further modified to dehydroaustinol which forms a diffusible complex with diorcinol that initiates conidiation (PubMed:22234162, PubMed:22329759). Due to genetic rearrangements of the clusters and the subsequent loss of some enzymes, the end products of the Emericella nidulans austinoid biosynthesis clusters are austinol and dehydroaustinol, even if additional enzymes, such as the O-acetyltransferase ausQ and the cytochrome P450 monooxygenase ausR are still functional (PubMed:29076725).</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis; terpenoid biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="3">Impairs the synthesis of austinol and dehydroaustinol and accumulates the intermediate compound preaustinoid A3 (PubMed:22329759).</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="8">In A.calidoustus, the austinoid gene cluster lies on a contiguous DNA region, while clusters from E.nidulans and P.brasilianum are split in their respective genomes. Genetic rearrangements provoked variability among the clusters and E.nidulans produces the least number of austionoid derivatives with the end products austinol and dehydroaustinol, while P.brasilianum can produce until acetoxydehydroaustin, and A.calidoustus produces the highest number of identified derivatives.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the trt14 isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF87256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VQ92"/>
    <dbReference type="SMR" id="C8VQ92"/>
    <dbReference type="STRING" id="227321.C8VQ92"/>
    <dbReference type="EnsemblFungi" id="CBF87256">
        <property type="protein sequence ID" value="CBF87256"/>
        <property type="gene ID" value="ANIA_11214"/>
    </dbReference>
    <dbReference type="GeneID" id="2867939"/>
    <dbReference type="KEGG" id="ani:ANIA_11214"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN11214"/>
    <dbReference type="eggNOG" id="ENOG502S4TQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108113_3_0_1"/>
    <dbReference type="InParanoid" id="C8VQ92"/>
    <dbReference type="OMA" id="NEYMIVL"/>
    <dbReference type="OrthoDB" id="3758478at2759"/>
    <dbReference type="UniPathway" id="UPA00213"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900560">
        <property type="term" value="P:austinol biosynthetic process"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900563">
        <property type="term" value="P:dehydroaustinol biosynthetic process"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.50:FF:000062">
        <property type="entry name" value="Austinol synthesis protein F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050977">
        <property type="entry name" value="Fungal_Meroterpenoid_Isomerase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39598:SF1">
        <property type="entry name" value="AUSTINOID BIOSYNTHESIS CLUSTERS PROTEIN F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39598">
        <property type="entry name" value="AUSTINOL SYNTHESIS PROTEIN F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000436491" description="Austinoid biosynthesis clusters protein J">
        <location>
            <begin position="1"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="Q5AR31"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="22234162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="22329759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="23865690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="29076725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="6">
        <source>
            <dbReference type="PubMed" id="22329759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="7"/>
    <evidence type="ECO:0000305" key="8">
        <source>
            <dbReference type="PubMed" id="29076725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBF87256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="162" mass="18431" checksum="BFEC2C6793619EB3" modified="2009-11-03" version="1">MNTTRHRLLATASRFVETLESLDVDAMLAIRSSTCLHHMCCPSFRNYSITNDQTREAFPQWKATITKYKFGVLDDSQILVDEQARKVMIHAETAAETTVGDYNNEYVFILRMAEDCNTVDEIWEFYDTIRLQDLRHRLEASHVPIGVDAPAPFTTTASPAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>C8VR63</accession>
    <name>C8VR63_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NCT transcriptional regulatory complex subunit B</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Negative cofactor 2 B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ANIA_09358</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Part of the NCT transcriptional regulatory complex that acts as a key regulator of ergosterol biosynthesis and the azole exporter cdr1B. The NCT complex binds the promoters of genes linked to azole susceptibility, and especially represses the expression of cdr1B transporter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Forms the NCT transcriptional regulatory complex with nctA and mot1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF87468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468969.1">
        <property type="nucleotide sequence ID" value="XM_050613130.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VR63"/>
    <dbReference type="FunCoup" id="C8VR63">
        <property type="interactions" value="832"/>
    </dbReference>
    <dbReference type="STRING" id="227321.C8VR63"/>
    <dbReference type="GeneID" id="2867827"/>
    <dbReference type="KEGG" id="ani:ANIA_09358"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN9358"/>
    <dbReference type="eggNOG" id="KOG0871">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066247_11_3_1"/>
    <dbReference type="InParanoid" id="C8VR63"/>
    <dbReference type="OMA" id="RDAKFKK"/>
    <dbReference type="OrthoDB" id="601405at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017054">
        <property type="term" value="C:negative cofactor 2 complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001046">
        <property type="term" value="F:core promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017055">
        <property type="term" value="P:negative regulation of RNA polymerase II transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016480">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd22905">
        <property type="entry name" value="HFD_Dr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000019">
        <property type="entry name" value="Negative cofactor 2 beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042225">
        <property type="entry name" value="Ncb2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46138">
        <property type="entry name" value="PROTEIN DR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46138:SF1">
        <property type="entry name" value="PROTEIN DR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="9">
        <location>
            <begin position="13"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="100"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="100"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00053814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00065193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00072420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00079659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBF87468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="145" mass="16350" checksum="16C28E135A3C041B" modified="2009-11-03" version="1">MSDREFSSNDDLSLPKATVQKIITEILPPSSGQSFSKDARDLLMECCVEFITLISSEANDISEKEAKKTIACEHVERALRDLGFGDYVPDVLAVAEEHKEQLKSREKKQSKMEQSGLSEEELLRQQQELFRSATEKYHAAPEGTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>C8VSG1</accession>
    <name>C8VSG1_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ANIA_01278</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF87807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_658882.2">
        <property type="nucleotide sequence ID" value="XM_653790.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VSG1"/>
    <dbReference type="STRING" id="227321.C8VSG1"/>
    <dbReference type="GeneID" id="2877054"/>
    <dbReference type="KEGG" id="ani:ANIA_01278"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN1278"/>
    <dbReference type="eggNOG" id="ENOG502SBMP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_162852_1_0_1"/>
    <dbReference type="InParanoid" id="C8VSG1"/>
    <dbReference type="OMA" id="TIRTHHV"/>
    <dbReference type="OrthoDB" id="10013825at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.10.10">
        <property type="entry name" value="Trypsin Inhibitor V, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021719">
        <property type="entry name" value="Prot_inh_I78"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39600">
        <property type="entry name" value="PEPTIDASE INHIBITOR I78 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39600:SF1">
        <property type="entry name" value="PEPTIDASE INHIBITOR I78 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11720">
        <property type="entry name" value="Inhibitor_I78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF87807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="114" mass="13176" checksum="AE9361E859C4A2F5" modified="2009-11-03" version="1">MSPSHIRILSQNNLYYFYLCLTTKHYHHSTKVKMPLVVPGITNTGSGNSKDDWLNKLVGKKISDSHNETCFAKQDLPESHRIVKPGDFTTMDYRPERLNIHLDENENVRDVNYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>C8VSG5</accession>
    <name>C8VSG5_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">D-xylose reductase [NAD(P)H]</fullName>
            <ecNumber evidence="3">1.1.1.307</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">ANIA_01274</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the initial reaction in the xylose utilization pathway by reducing D-xylose into xylitol. Xylose is a major component of hemicelluloses such as xylan. Most fungi utilize D-xylose via three enzymatic reactions, xylose reductase (XR), xylitol dehydrogenase (XDH), and xylulokinase, to form xylulose 5-phosphate, which enters pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>xylitol + NAD(+) = D-xylose + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27441"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17151"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.307"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>xylitol + NADP(+) = D-xylose + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27445"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17151"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.307"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.307" evidence="3"/>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF87813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_658878.2">
        <property type="nucleotide sequence ID" value="XM_653786.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VSG5"/>
    <dbReference type="FunCoup" id="C8VSG5">
        <property type="interactions" value="487"/>
    </dbReference>
    <dbReference type="GeneID" id="2877051"/>
    <dbReference type="KEGG" id="ani:ANIA_01274"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN1274"/>
    <dbReference type="eggNOG" id="KOG1577">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_0_0_1"/>
    <dbReference type="InParanoid" id="C8VSG5"/>
    <dbReference type="OMA" id="MHWPASL"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004032">
        <property type="term" value="F:aldose reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006066">
        <property type="term" value="P:alcohol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019568">
        <property type="term" value="P:arabinose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042843">
        <property type="term" value="P:D-xylose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042180">
        <property type="term" value="P:ketone metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000018">
        <property type="entry name" value="Glycerol dehydrogenase Gcy1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="12">
        <location>
            <begin position="21"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="11">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CBF87813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="297" mass="33405" checksum="AB34E3E7F4083116" modified="2009-11-03" version="1">MSLEHTKKVYTLNTGDKIPAIGLGTWQSKPNEVREAVKNALLKGYRHIDTALAYGNEAEVGQGIKDSGVPREEIWITTKLDNTWHHRVTDGINSSLKDLGVDYVDLYLMHWPSSTDPNDLKKHLPDWDFIKTWQEMQKLPATGKVRNIGVSNFGIRNLEKLLNDPSCKIVPAVNQIELHPNNPSPKLVAYNSSKGIHSTGYSCLGSTNSPLYKDPTLLKLAEKKGKTPQQVLLVWGIQKGWSVIPKSVSKSRIDANFEIDGWSLTDEEINELDNLKDRFKVCGDDWLPIKVFFGDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>C8VUB6</accession>
    <name>C8VUB6_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">6-phosphogluconolactonase</fullName>
            <shortName evidence="6">6PGL</shortName>
            <ecNumber evidence="4 6">3.1.1.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ANIA_00285</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12556"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57955"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="EC" id="3.1.1.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 6">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.31" evidence="4 6"/>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF89810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050469270.1">
        <property type="nucleotide sequence ID" value="XM_050610996.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VUB6"/>
    <dbReference type="FunCoup" id="C8VUB6">
        <property type="interactions" value="262"/>
    </dbReference>
    <dbReference type="STRING" id="227321.C8VUB6"/>
    <dbReference type="GeneID" id="2876064"/>
    <dbReference type="KEGG" id="ani:ANIA_00285"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN0285"/>
    <dbReference type="eggNOG" id="KOG3147">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053947_0_1_1"/>
    <dbReference type="InParanoid" id="C8VUB6"/>
    <dbReference type="OMA" id="YQLFEFE"/>
    <dbReference type="OrthoDB" id="432544at2759"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00409"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017057">
        <property type="term" value="F:6-phosphogluconolactonase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009051">
        <property type="term" value="P:pentose-phosphate shunt, oxidative branch"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd01400">
        <property type="entry name" value="6PGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1360:FF:000005">
        <property type="entry name" value="6-phosphogluconolactonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005900">
        <property type="entry name" value="6-phosphogluconolactonase_DevB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039104">
        <property type="entry name" value="6PGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006148">
        <property type="entry name" value="Glc/Gal-6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01198">
        <property type="entry name" value="pgl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11054">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11054:SF0">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01182">
        <property type="entry name" value="Glucosamine_iso"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucosamine/galactosamine-6-phosphate isomerase" evidence="7">
        <location>
            <begin position="13"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBF89810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="265" mass="28742" checksum="B81CF0AA012ABF26" modified="2009-11-03" version="1">MPGPAPNLFSFQDTDALAKQLRPYVLRNQNAALSRHNTFRVAVSGGSLPTVLAKALLAPGDGTPEDTAQFSKWEIFFADERAVPLDHEDSNYRLLKDELLSKIPSELGSPNVHTIDEKHVNGDPQELADLYQEELMRSFAAKDSVKLPVFDLILLGCGPDGHTCSLFPGHELLREKDAWVSAISDSPKPPPKRITLTLPVVTHAVSIAFVATGGGKKDILKQIFDAEEGRSLPSALVNQGGGEKVSWFTDHAAVDGVAFPRRGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>C8VUM7</accession>
    <name>C8VUM7_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ANIA_11265</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF89923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050469290.1">
        <property type="nucleotide sequence ID" value="XM_050611017.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VUM7"/>
    <dbReference type="GeneID" id="74896875"/>
    <dbReference type="KEGG" id="ani:ANIA_11265"/>
    <dbReference type="HOGENOM" id="CLU_3050308_0_0_1"/>
    <dbReference type="InParanoid" id="C8VUM7"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF89923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="54" mass="6247" checksum="6A41E90E5D23FA09" modified="2009-11-03" version="1">MRKSVKRVSVQSTFLVDLAPFRRAALKFLAMPHANGEWLCQRYKSKNVKLLPSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-12-14" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>G5EB43</accession>
    <accession>C8VJA4</accession>
    <name>G5EB43_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">amidase</fullName>
            <ecNumber evidence="3">3.5.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ANIA_02879</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a monocarboxylic acid amide + H2O = a monocarboxylate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:12020"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:35757"/>
            <dbReference type="ChEBI" id="CHEBI:83628"/>
            <dbReference type="EC" id="3.5.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amidase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.4" evidence="3"/>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF83822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_660483.1">
        <property type="nucleotide sequence ID" value="XM_655391.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G5EB43"/>
    <dbReference type="FunCoup" id="G5EB43">
        <property type="interactions" value="48"/>
    </dbReference>
    <dbReference type="STRING" id="227321.G5EB43"/>
    <dbReference type="GeneID" id="2874088"/>
    <dbReference type="KEGG" id="ani:ANIA_02879"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN2879"/>
    <dbReference type="eggNOG" id="KOG1212">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009600_9_2_1"/>
    <dbReference type="InParanoid" id="G5EB43"/>
    <dbReference type="OMA" id="GQSEYPF"/>
    <dbReference type="OrthoDB" id="6428749at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004040">
        <property type="term" value="F:amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043605">
        <property type="term" value="P:amide catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072:SF3">
        <property type="entry name" value="AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072">
        <property type="entry name" value="AMIDASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001221">
        <property type="entry name" value="Amidase_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="7">
        <location>
            <begin position="83"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="214"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="5">
        <location>
            <position position="238"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="235"/>
            <end position="238"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBF83822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="543" mass="59151" checksum="A4EB017D8E08E2F4" modified="2011-12-14" version="1">MAEETWQAAVAERRRILDLLIPTDWKLSGEFRASLPADGRLLQADPVRKSGILSEDELDITENYSAGQLLQRLARGDVSSLAVTTAFCKRAAIAQQLTSCLTEHFFAQAIERARYLDEYLKREGKVVGPLHGLPISIKDSFQVKGLHTTVGYVSFLKNGPATENSAMVDLLLDLGAVLYVKTNIPQTLMTADSENNIYGRTLNPHNTNLTAGGSSGGEGALIAFRGSILGVGTDVAGSIRIPALCCGLYGFKPTTDRVPFGGQVSGVAEETPMISPSAGPLAQSFDDLELFMSRVLAAGPWRYDPAAVAMPWIRHTEPQSLLSVGILPEDKHFPLHPPVKRALESAIENLKRMGHRIIRLPSDPSRDIADANRLAFEFFTYGPRLDHITPSGEPVVTSVATLPSPMFSGPPYLSQDLGVFDKIKILQIARKKYSESWRRTIVENEIDVILAPGAQNTAVPHDSYGWPPYTAIWNLLDYPACIIPYGKASKELDPEPMVVGGGQPGYDPEAVDGAPCALQIVAPRFQDEKCLAAARIIDRDIRV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-02-21" modified="2026-01-28" version="136" xmlns="https://uniprot.org/uniprot">
    <accession>P78621</accession>
    <accession>C8V0K5</accession>
    <accession>Q00760</accession>
    <accession>Q5AYV7</accession>
    <name>SEPA_EMENI</name>
    <protein>
        <recommendedName>
            <fullName>Cytokinesis protein sepA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Forced expression inhibition of growth A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Protein FH1/2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">sepA</name>
        <name type="synonym">figA</name>
        <name type="ORF">AN6523</name>
    </gene>
    <organism>
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1997" name="EMBO J." volume="16" first="3474" last="3483">
            <title>The Aspergillus nidulans sepA gene encodes an FH1/2 protein involved in cytokinesis and the maintenance of cellular polarity.</title>
            <authorList>
                <person name="Harris S.D."/>
                <person name="Hamer L."/>
                <person name="Sharpless K.E."/>
                <person name="Hamer J.E."/>
            </authorList>
            <dbReference type="PubMed" id="9218790"/>
            <dbReference type="DOI" id="10.1093/emboj/16.12.3474"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <reference key="2">
        <citation type="submission" date="2001-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Hamer L."/>
                <person name="Harris S.D."/>
                <person name="Sharpless K.E."/>
                <person name="Hamer J.E."/>
            </authorList>
        </citation>
        <scope>SEQUENCE REVISION TO 143-153; 207; 1071-1109 AND 1644</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="5">
        <citation type="journal article" date="1995" name="Genetics" volume="139" first="537" last="547">
            <title>Identification of developmental regulatory genes in Aspergillus nidulans by overexpression.</title>
            <authorList>
                <person name="Marhoul J.F."/>
                <person name="Adams T.H."/>
            </authorList>
            <dbReference type="PubMed" id="7713416"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 559-1790</scope>
        <scope>FUNCTION</scope>
        <source>
            <strain>FGSC 26</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in cytokinesis. Overexpression results in growth inhibition.</text>
    </comment>
    <comment type="domain">
        <text evidence="1">The DAD domain regulates activation via by an autoinhibitory interaction with the GBD/FH3 domain. This autoinhibition is released upon competitive binding of an activated GTPase. The release of DAD allows the FH2 domain to then nucleate and elongate nonbranched actin filaments.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the formin homology family. BNI1 subfamily.</text>
    </comment>
    <comment type="sequence caution" evidence="8">
        <conflict type="erroneous gene model prediction">
            <sequence resource="EMBL-CDS" id="AAA33306" version="1"/>
        </conflict>
    </comment>
    <comment type="sequence caution" evidence="8">
        <conflict type="frameshift">
            <sequence resource="EMBL-CDS" id="AAA33306" version="1"/>
        </conflict>
    </comment>
    <comment type="sequence caution" evidence="8">
        <conflict type="erroneous gene model prediction">
            <sequence resource="EMBL-CDS" id="CBF70912" version="1"/>
        </conflict>
    </comment>
    <comment type="sequence caution" evidence="8">
        <conflict type="miscellaneous discrepancy">
            <sequence resource="EMBL-CDS" id="CBF70912" version="1"/>
        </conflict>
        <text>An additional intron is predicted in this sequence to correct a probable sequencing error.</text>
    </comment>
    <comment type="sequence caution" evidence="8">
        <conflict type="erroneous gene model prediction">
            <sequence resource="EMBL-CDS" id="EAA57863" version="1"/>
        </conflict>
    </comment>
    <comment type="sequence caution" evidence="8">
        <conflict type="miscellaneous discrepancy">
            <sequence resource="EMBL-CDS" id="EAA57863" version="1"/>
        </conflict>
        <text>An additional intron is predicted in this sequence to correct a probable sequencing error.</text>
    </comment>
    <dbReference type="EMBL" id="U83658">
        <property type="protein sequence ID" value="AAB63335.3"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AACD01000109">
        <property type="protein sequence ID" value="EAA57863.1"/>
        <property type="status" value="ALT_SEQ"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="L36341">
        <property type="protein sequence ID" value="AAA33306.1"/>
        <property type="status" value="ALT_SEQ"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF70912.1"/>
        <property type="status" value="ALT_SEQ"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_664127.1">
        <property type="nucleotide sequence ID" value="XM_659035.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P78621"/>
    <dbReference type="SMR" id="P78621"/>
    <dbReference type="FunCoup" id="P78621">
        <property type="interactions" value="463"/>
    </dbReference>
    <dbReference type="STRING" id="227321.P78621"/>
    <dbReference type="KEGG" id="ani:ANIA_06523"/>
    <dbReference type="eggNOG" id="KOG1922">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001313_1_0_1"/>
    <dbReference type="InParanoid" id="P78621"/>
    <dbReference type="OrthoDB" id="1104827at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005934">
        <property type="term" value="C:cellular bud tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000131">
        <property type="term" value="C:incipient cellular bud site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110085">
        <property type="term" value="C:mitotic actomyosin contractile ring"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051017">
        <property type="term" value="P:actin filament bundle assembly"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903475">
        <property type="term" value="P:mitotic actomyosin contractile ring assembly"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.150:FF:000003">
        <property type="entry name" value="Cytokinesis protein SepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.2220:FF:000006">
        <property type="entry name" value="Cytokinesis protein sepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000291">
        <property type="entry name" value="Cytokinesis protein sepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.30.50:FF:000001">
        <property type="entry name" value="Cytokinesis sepA protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.30.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2220">
        <property type="entry name" value="Formin, FH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.150">
        <property type="entry name" value="Formin, FH3 diaphanous domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051661">
        <property type="entry name" value="Actin_filament_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014767">
        <property type="entry name" value="DAD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015425">
        <property type="entry name" value="FH2_Formin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042201">
        <property type="entry name" value="FH2_Formin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010472">
        <property type="entry name" value="FH3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014768">
        <property type="entry name" value="GBD/FH3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010473">
        <property type="entry name" value="GTPase-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47102">
        <property type="entry name" value="PROTEIN BNI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47102:SF2">
        <property type="entry name" value="PROTEIN BNI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06367">
        <property type="entry name" value="Drf_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06371">
        <property type="entry name" value="Drf_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02181">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01139">
        <property type="entry name" value="Drf_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01140">
        <property type="entry name" value="Drf_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00498">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51231">
        <property type="entry name" value="DAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51444">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51232">
        <property type="entry name" value="GBD_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0132">Cell division</keyword>
    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000194903" description="Cytokinesis protein sepA">
        <location>
            <begin position="1"/>
            <end position="1790"/>
        </location>
    </feature>
    <feature type="domain" description="GBD/FH3" evidence="4">
        <location>
            <begin position="274"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="domain" description="FH1">
        <location>
            <begin position="955"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="domain" description="FH2" evidence="5">
        <location>
            <begin position="1141"/>
            <end position="1564"/>
        </location>
    </feature>
    <feature type="domain" description="DAD" evidence="3">
        <location>
            <begin position="1581"/>
            <end position="1613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="328"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="975"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1465"/>
            <end position="1484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1596"/>
            <end position="1790"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="724"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="1435"/>
            <end position="1566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="39"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="187"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="205"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="328"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="975"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="1015"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="1033"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1608"/>
            <end position="1620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1644"/>
            <end position="1661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1694"/>
            <end position="1710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1720"/>
            <end position="1746"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 3; EAA57863/CBF70912." evidence="8" ref="3">
        <location>
            <position position="713"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 5; AAA33306." evidence="8" ref="5">
        <original>P</original>
        <variation>T</variation>
        <location>
            <position position="1104"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 5; AAA33306." evidence="8" ref="5">
        <original>D</original>
        <variation>V</variation>
        <location>
            <position position="1476"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 5; AAA33306." evidence="8" ref="5">
        <original>V</original>
        <variation>L</variation>
        <location>
            <position position="1504"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="7">
        <source>
            <dbReference type="PubMed" id="7713416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="8"/>
    <sequence length="1790" mass="197356" checksum="192136DE2EF2A75B" modified="2001-08-14" version="2">MPTSDKSRQTSAGKSFFGRKLHKERPVEDRWDAHGSWESLAPPSSAAGSRSSRYSKRSSIQSVDFGADIDPSLLSTSAGPITSIPFESLSTDTQSPIPVDYLSKAETSPRKEPSPGHLAKGVGDFHQYPAWDPSAMRNHQQFSHPTGPRPPPHAAGVAMSSSATGDKGARYQQWGRPGSSAGNAGLSHHSSSTVDSSTNSRMSIDQASIHSSLSSNTRGSSYISTDGSSRTTLPSHSNDRSNYYAAMNSGRGSSAQGAIPPAQPRVQNTEQYLTRPRDDRVVDQLFLELMQKRGWQNLPEQARRQMMAYPASKKWTLVHQDRLTELQGEQKRKQKARETHGYDGPSGILERADEEGSPEWYVKKVMDDTITSKQLASLSVSLRTQPISWVKAFVEAQGQIALTNVLVKINRKKVTGPVPAPPSGDKDLDREYDIVKCLKALMNNKYGADDALAHQQIIVALISSLLSPRLNTRKLVSEVLTFLCHWAEGQGHERVLQAMDHVKNHQGETGRFDAWMRIVEVTIDGRGKMGSLVGASEEYRSGGIGMENLLMEYAVSTMILINMLVDAPENDLQLRCHIRAQFISCGIKRLLSKMEGFQYEVIDKQIEHFRENEAIDYEDLLQRESSSTKDSIEGEVKDMTDPLQITDAIASRLNGTRAHDYFLSALQHLLLIRENSGEDGLRMYQLVDAMLSYVAMDRRLPDLDLRQGLTFTVQSLLDRLHTDAEARRAYDESLEARQIAEAALAERDEMKAQVELGADGLVRKLQKQIEEQTGIIELQSRQNEMLKAELADVQRLRAQELQRNELETRELYLMLRDAQDIAASNAKKSNMGEAETDPAHMRGILDREKLLTRLEKQLERTKTQFKLEGKVWGQHDPSDRLRELREQMDGDAGPREAFEEQARLNLSLNPVGSVYRKKTYIQGMEDTATEELGQTDDEVVYAKARLVDLHRPRMDPEQATGLLGEIAAKVPKIDADDAKDEGKPTESEQPAEGAATKGDEQGVDDTVAVDKATAAPPPPPPPPPAHPGLSGAAPPPPPPPPPPPPGAGAAPPPPPPPPPPPPGGLGGPPPPPPPPPPGGFGGPPPPPPPPGGFGGPPPPPPPPPGGAFGVPPPPPPPGTVIGGWRANYLASQGAPSHAIPVMSSIRPKKKLKALHWDKVDTPQVTVWATHGTTPQEKEEKYVELAKRGVLDEVERLFMAKETRIFGGGVAAKQRKDKKQIISNDLSKNFQIALSKFSQFPAEEVVRRIIHCDAEILDNMVVMEFLQRDEMCTVPENVSKLMAPYSKDWTGPDAANTEREQDPSELTREDQIYLYTAFELNHYWKARMRALALTRSFEPDYEHISAKLREVVRVSESLRDSVSLMNVLGLILDIGNFMNDANKQAQGFKLSSLARLGMVKDDKNETTFADLVERIVRNQYPEWEDFTEQISGVIGLQKLNVDQLRTDAKKYIDNIKNVQASLDAGNLSDPKKFHPQDRVSQITQRSMKDARRKAEQMQLYLEEMVKTYDDIMVFYGEDNTDDGARRDFFAKLAAFLQEWKKSKEKNIALEEARRRTEASLARKRINVGLANGAGAAGDAPVSPATSGAMDSLLEKLRAAAPQAKDQRDRRRRARLKERHQVRVASGQKIPDLEGAEAPGSGGQNSGATDTNATDSSLLSPTIQEPEGGSSPIASQSEDVADRAASMLQDMLRNSPDPERTRRRRESAEEERRKRRLRRRNGATSGSKDSNDTTPLSPVTEPTSTQGESAEPENLSLSSPPNGEDPTLNPPTIVLSSDASDTPDDEHRPSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AQI7</accession>
    <accession>C8VN96</accession>
    <name>Q5AQI7_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transaldolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_09443</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF85197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_868825.1">
        <property type="nucleotide sequence ID" value="XM_863732.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AQI7"/>
    <dbReference type="STRING" id="227321.Q5AQI7"/>
    <dbReference type="GeneID" id="3684036"/>
    <dbReference type="KEGG" id="ani:ANIA_09443"/>
    <dbReference type="eggNOG" id="KOG2772">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047470_1_0_1"/>
    <dbReference type="InParanoid" id="Q5AQI7"/>
    <dbReference type="OMA" id="SKEIGPF"/>
    <dbReference type="OrthoDB" id="1711136at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004801">
        <property type="term" value="F:transaldolase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009052">
        <property type="term" value="P:pentose-phosphate shunt, non-oxidative branch"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001585">
        <property type="entry name" value="TAL/FSA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683">
        <property type="entry name" value="TRANSALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683:SF34">
        <property type="entry name" value="TRANSALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00923">
        <property type="entry name" value="TAL_FSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0704">Schiff base</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF85197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="303" mass="33697" checksum="C70754F1DCB1C202" modified="2005-04-26" version="1">MEETRVNLLEYLRSKTQVDLDTFDITGISFPRLLEHTLNLETVAAGLHDQFPEVTFDELGVEVGAVLLAGEMVPAFTGNLHLMVNPSYAYSREKVIEAAKSTPSPISLYPVLPATWEGLQACRDLQAFKIKTLGTTLFSMEQAILAGEAGCVSISPFVHSLRILVDPEYKDPHPVYNLSAQAQRWYRRQSLPTKVKSCSTVGVDELLELAGIDALTIIPDDLRALQSTYRDANQVFKLSIVENGTQNDDKIEHISYINDEEKYRADFQKADEGRAKAKTAEAIDIFCGFQAKAEDVIRKAKGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="138" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ASB8</accession>
    <accession>C8V9M4</accession>
    <name>Q5ASB8_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">ABC transporter (Eurofung)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">ANIA_08812</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCA family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF77969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <location>
            <begin position="224"/>
            <end position="247"/>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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            <dbReference type="EMBL" id="CBF77969.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="15">
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            <dbReference type="Proteomes" id="UP000000560"/>
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    </evidence>
    <sequence length="1626" mass="178969" checksum="BB4F92F965B13DE8" modified="2005-04-26" version="1">MTVPMLGRYSYVDSDSQKPTGCPCSPSTLDRFSSIDPACALCGIHVCTSKPAPWHSLRCMSDVNADPTYGIGEPTRVQSFSNALESVGAGRNRLIFVDNGFVGGSIEQVINEVAEPARTSQYEVHVLSDESEMRELCRTSLREGPAEAWNYTIRTDSVLGKGIDVGNSNNDQQVYLLPFQRSIDWAIARTNSSFDASTLPEETLEYPYTSLNEEGRKDRIRTRYMGAIIDVIAVAVFIGMVGVTYQLTGLIAMERELGMSQLIDCMMPDSSPWMSQAARFCAAHLALDIVYGPGWIIMGAILKAGVYSETSAGITVVYHILCGLALSSFSIFGASFFRKAQLSGISVVLACLLLGVVAQMAPAKSNGPVVILGLLFPSMNYVYFSIFVARWERENSAAILTESAPNNPWSLPGVVLWVLLILQIIIYPMLAAVVERMLYGTASKNRHVSSSGTSAALSIRNLNKIYRPGWFYRTIGPLFGSNRQTVHAVNNLSIDVNKGQIMVLLGANGSGKSTTLDAIAGLTKLSSGDININYGTEEPGFGLCPQKNVLWDNLTVKEHVKIFNRLKSTGKVDTEEQIMHLLRDCDLQKKAKARSKTLSGGQKRKVQLAMMFTGGSPICCVDEVSSGLDPISRRKIWDILLAERGSRTIILTTHFLDEADLLADHIAILSKGVLKAKGSSVELKNQLGSGYRIHVFNVPGSERAVQKRFSSIHKEVHFDETVYTVQNSAEAAQFVSELEQEGMMEYRVSGPTIEDVFLKVASELDFEPSRGRVREGERAADHSSEADDENIERRSLHLMTGCRIGIILQAWYLFRKRLTILRRNPLPYLAAFMIPVIAAGLVTLFLQGVAKPGCSGEDSYRTPESTIADQWDNLLLVIGPSDKVQPELLESFVVSMNDQSDAVQSSSNASQFYIVDDYPDFSDYIKANYSKVTPGGVYLGDSSWQPTIAWKGDNGNFPLAALTQNVLDRFATGMSINIGFDFFDIPSTPDFYNTLQLVVYFGLAMSVYPAFFALYPTVERLRNVRALQFSNGVRALSLWLAYISFDFCLVVASSVLAVIIFRAVTNIWYHIEYLFAVFFLYGLCGTLCAYLVSLFTKSQLAAFAFAAGFQCVMFLIYLIAYMCVLTYASTDKIDSYIDITHYTIAIVSPSGNLLRALFASLNVFSILCRGSEGREIASYPGEIGLYGGPILYLILQSIFLVVLLVWIEGGTPLLSWLRPKSRQRDVEEKELMDSDIAEEITRVSSSKDNLRLLHVSKAFKKFIAVEDVTFGVGAGEVFALLGPNGAGKTTTISLIRGDIQPTRNEGEIFVENISVLKQRAVARSRLGVCPQFDAMDQMTVLEHLVFYARIRGVPDINHNVNEVINAVGLKQFRHRMAAKLSGGNKRKLSLGIALMGNPSVLLLDEPSSGMDAASKRVMWKTLTAVAPGRSIVLTTHSMEEADALAHRAGIMARRMLALGTTDALRLKYGNMYHVHIVHTQAPHTSDEDMEKIRGWVTDNFPGAVIEQKTYHGQLRFSVPAGISPEKERAAHSDDSKGSSYRDIRSTDELRSVSLRSDVSIPVGLGPDTETGPGNFRARSGVSKLFSQLEQNKAALGVEHYSVSQTTLDQVFLTIVGKHHISEQDSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="99" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ATF7</accession>
    <accession>C8VEC8</accession>
    <name>Q5ATF7_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ANIA_08423</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF80516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_676600.1"/>
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    <dbReference type="AlphaFoldDB" id="Q5ATF7"/>
    <dbReference type="GeneID" id="2868848"/>
    <dbReference type="KEGG" id="ani:ANIA_08423"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_4_2_1"/>
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    <dbReference type="OMA" id="FQCTSYV"/>
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        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
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    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
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    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000065">
        <property type="entry name" value="Putative MFS pantothenate transporter"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
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    <dbReference type="PANTHER" id="PTHR43791:SF28">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="114"/>
            <end position="135"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="178"/>
            <end position="199"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="244"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="314"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="360"/>
            <end position="380"/>
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    <feature type="transmembrane region" description="Helical" evidence="7">
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            <begin position="387"/>
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    <feature type="transmembrane region" description="Helical" evidence="7">
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            <begin position="411"/>
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    <feature type="transmembrane region" description="Helical" evidence="7">
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            <begin position="443"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="477"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBF80516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="546" mass="62420" checksum="6615B5CDCB3454B3" modified="2005-04-26" version="1">MTDQVAKGKTSLDQPMAVDASQNPAFEDVKIADAERDAAPASISSAHKPKPRSLWVAWLYLFDWYPSHYSKQERKLLFKLDCVLLPLCCLAYFIKWLDQVNINNAYSSGMKEDLNLYGNEYSLFGTFYNIGYMLFEIPSMMIMSRPKFARYFLPTMEVCWSVLTFAQSRLRNHHDIYGLRFLLGVLETPVSSGTMYILSSWYRGDELFKRAGVWFVSSNLGSFAGGYLQAAAHETLDGVHGMAGWRWLFIIDGCISLPIALGSFFFFPGLPHGEKVWWLTDADHRLCVQRMRNEGVRESRKIGKRMLRRVFTHWHFYIAVFTYIFFQCTSYVAGQMILWLKDQADRYGTWTVSQINMIPTGVQAVSVFAGVLATSLVMVYPPWAVMGVVASVLLFSNVCLLVWDIPLGLKFTAYYLLGFTSCVTPILFPWVNMVMRDDSEARAFTSGAMMTFGWVFFSFYPITVFPVVEAPKWRKGYAVNTIFVICWCTLFMVGQWLWRRDVKAGKYSVGEYAIKDKEEESDGKDIDAKREVLEHVEVLDGKGAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ATW6</accession>
    <accession>C8V3N6</accession>
    <name>Q5ATW6_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_08264</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF74239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_681533.1">
        <property type="nucleotide sequence ID" value="XM_676441.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ATW6"/>
    <dbReference type="GeneID" id="2869107"/>
    <dbReference type="KEGG" id="ani:ANIA_08264"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN8264"/>
    <dbReference type="eggNOG" id="ENOG502RZIA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026017_0_0_1"/>
    <dbReference type="InParanoid" id="Q5ATW6"/>
    <dbReference type="OMA" id="MRFFMRA"/>
    <dbReference type="OrthoDB" id="5328412at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF74239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="497" mass="55127" checksum="B108260B6BDECAB8" modified="2005-04-26" version="1">MPKPKSFLKETKLKKKSAQQQAPRTADEFLAVGVEQEEAGEKWRAGDAAKSLRFFMRAIATYDEGLQKHPTAFDLAYNKARVQYEITQHPRLAAQLSIPLVEALSVALQSHREALVLEQDNADALFNTAQVLTSLAETVTDTKRPVEEDLNQAAKFLQEAIELFQRCLVLQELKYTEMQEQIRQMESGEVGRMEQVQESKQMQESPDVESQESEQEQWAAVVEPVTKDTLVDTAIAQLDALSTLCNLLAFDPGVGLKWAEEYSRDSLQKKLSTLVEGSNRHYEVNLSRARFNAALNEVLYRSGRIDVATYHGVVVSSFGDLDVSADPEGLCAKADAFISFNTASAEQPPHDPEVLKKSLGLRWQALSTAIDMLTKASKLPDAENLPKIHLARGDAEMSRWRLGFAPWEHSMAQQYGATLLRNAQTYYRGAAALARRDGGADEERDGTCKEAIAAAIEGQKEKLAQLKGSAPKELLQVAEDMVEEGWVSGPDMEALLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AU34</accession>
    <accession>C8V760</accession>
    <name>Q5AU34_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Hydrophobin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_08196</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF74087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_681465.1">
        <property type="nucleotide sequence ID" value="XM_676373.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AU34"/>
    <dbReference type="SMR" id="Q5AU34"/>
    <dbReference type="STRING" id="227321.Q5AU34"/>
    <dbReference type="GeneID" id="2869246"/>
    <dbReference type="KEGG" id="ani:ANIA_08196"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN8196"/>
    <dbReference type="HOGENOM" id="CLU_1261497_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AU34"/>
    <dbReference type="OMA" id="YEAYTCP"/>
    <dbReference type="OrthoDB" id="4292214at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010273966" description="Hydrophobin" evidence="2">
        <location>
            <begin position="26"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF74087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="219" mass="22590" checksum="1ECE24A259231E07" modified="2005-04-26" version="1">MQLQFSTLPGLLAVFVAFPLTSTFANPVEINSSPIPSAFPQSPSAGASASVNAGANANGPSIQEPERPIPSLKPEQATASQSLVHSIATLIASSAASSLDPTTCPPTHNSRQCCTSVDSLADDVVGEDAIGGLIPWFQGVKISSIVGFQYGTKANVDSGNRGDRTNLNGQPGTQSLFKSGCIPYDKAIQDKKEAIEKSKAEASYLAAQSSSVPTPTPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="146" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AU91</accession>
    <accession>C8V6U7</accession>
    <name>Q5AU91_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Cytochrome P450, putative (Eurofung)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">ANIA_08139</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF73963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_681408.1">
        <property type="nucleotide sequence ID" value="XM_676316.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AU91"/>
    <dbReference type="GeneID" id="2869208"/>
    <dbReference type="KEGG" id="ani:ANIA_08139"/>
    <dbReference type="eggNOG" id="KOG0157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022195_0_3_1"/>
    <dbReference type="InParanoid" id="Q5AU91"/>
    <dbReference type="OMA" id="EMFENDH"/>
    <dbReference type="OrthoDB" id="1844152at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd11041">
        <property type="entry name" value="CYP503A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206:SF2">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE AUSG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12 13" id="KW-0349">Heme</keyword>
    <keyword evidence="9 12 13" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 13" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="467"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CBF73963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="529" mass="60007" checksum="8B034F2CF6651071" modified="2005-04-26" version="1">MLQSLLQNNFVAVLGLLIVFGTATSLTWTAFTILSPYLRVKGAKIFNDRTGSEILWTNARKRFQRGARELFKAAFAQHPNAFYIMTDTDVELILDSKYAPEVRNDRRFDIGKYNEDMFHGTIAGFEMFENDHVLERVFVETVRNKLTRAIGKFVKPISLEAADGLREYWTDDTGIPAPTRNHSCVLRTIAKQSSRVFQGPPLCYNPDWLRITVNHTVTFFEAAESLKVWPHPLRPLAAKFLPLCKKLRAEAQEARRIITPILEERLKRAQARMAEKNNLPEKKTEVKEEGDSDGNMIEWAEETANGAIYDAALLQMKVSLASIHTTSDLVSQTLFNLCSRPELVNDLRKEVIEVIGQQGWVKPALYQLKLMDSVLKETQRLKPISIGTMVRTTTSPVTFSDGLQVPANTRTLVSCHNMWTESVHENPEVFDGYRFLKLRQLPGQENWTQLVSTSNNHLGFGHGMHACPGRFFAATTAKVLIAHVVLKYDLKLLDGQKPVIIEHGAAQYANVWCPIGVRRRREEIDLSDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="121" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AUC8</accession>
    <accession>C8V6L2</accession>
    <name>Q5AUC8_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Aspartic-type endopeptidase, putative (AFU_orthologue AFUA_3G01220)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ANIA_08102</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF73891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_681371.1">
        <property type="nucleotide sequence ID" value="XM_676279.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AUC8"/>
    <dbReference type="MEROPS" id="A01.081"/>
    <dbReference type="GeneID" id="2869216"/>
    <dbReference type="KEGG" id="ani:ANIA_08102"/>
    <dbReference type="eggNOG" id="KOG1339">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035052_1_0_1"/>
    <dbReference type="InParanoid" id="Q5AUC8"/>
    <dbReference type="OMA" id="YTINIDA"/>
    <dbReference type="OrthoDB" id="15189at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF47">
        <property type="entry name" value="ENDOPEPTIDASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01220)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase A1" evidence="5">
        <location>
            <begin position="49"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="309"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="346"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBF73891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="458" mass="49152" checksum="F4A690BC071E616A" modified="2005-04-26" version="1">MRHLVASSLLASAAAVNLPRHHLQIRQSSNTTRTAHTIPLTATLYGSRYNAPVTIGNTEFDLLVDTGSSDTFVIETGYECFGQSVYTGDIVTAEQSQCAYASETYNPSESDTFEPINNETFIAAYGAGVATGSMAYEDITLGGVTVTDQRFGLVNRSSPMGLGASGILGLAYPVITSAYEVNGTLEDYVDDLAEDLDDDDVDTSIEQEPYSPLFVNMARRGLVEPYFSLALERLDGDSETGDGGVLVLGGLPDVKLANNFTTVAAEYYEAAEFRSDNGTRLRSYWATTVQRISYGGDGEYTASYQTIVDSGAPMNYVPTEVADGFNQAFSSSAQWDDTQGAYRVDCDANAPDFAVQLGGTTFKLNPTDLVLRSGVEFGGEEICVSAVTRGLEQQINETDTTELYILGAGFLKGVVAVFDFGNSEMRFAERDTSAASVLEVFGGRKLAVVLGVMFALLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AUT4</accession>
    <accession>C8V581</accession>
    <name>Q5AUT4_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Intradiol ring-cleavage dioxygenases domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ANIA_07946</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF73576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_681215.1">
        <property type="nucleotide sequence ID" value="XM_676123.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AUT4"/>
    <dbReference type="GeneID" id="2868955"/>
    <dbReference type="KEGG" id="ani:ANIA_07946"/>
    <dbReference type="eggNOG" id="ENOG502QPRK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_994076_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AUT4"/>
    <dbReference type="OMA" id="HESHETQ"/>
    <dbReference type="OrthoDB" id="121380at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.130.10">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000627">
        <property type="entry name" value="Intradiol_dOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015889">
        <property type="entry name" value="Intradiol_dOase_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34315">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34315:SF9">
        <property type="entry name" value="INTRADIOL RING-CLEAVAGE DIOXYGENASES DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00775">
        <property type="entry name" value="Dioxygenase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49482">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010255828" description="Intradiol ring-cleavage dioxygenases domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="Intradiol ring-cleavage dioxygenases" evidence="3">
        <location>
            <begin position="111"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBF73576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="280" mass="30441" checksum="785F287275A434C3" modified="2005-04-26" version="1">MRFRASALLALAAPALALAHGTFEHESHETQLLKRNFFHIGSRSLKSYAGNLNSHGTNARARRHRAAVVSYHRRALAQKRSMVEVLNTSHLYGGDCIGPNARAPPSPTSTTSSRPTLIRSDAREDQEGVPIIVEAQVIDFITCKPAPGMWWDMWNANATGVYSGVINEGNGDFTDHSNINNTFLRAVQQADQDGVAQIKTIFPGHYTGRTTTSILSRTRMRNAHGIRTLETLPGENGPGPAVYDSPLPSAWDDETDAAEISAAKSWLEEQNNVAAATQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AUU0</accession>
    <accession>C8V575</accession>
    <name>Q5AUU0_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ANIA_07940</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PrpD family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF73564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_681209.1">
        <property type="nucleotide sequence ID" value="XM_676117.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AUU0"/>
    <dbReference type="STRING" id="227321.Q5AUU0"/>
    <dbReference type="GeneID" id="2869141"/>
    <dbReference type="KEGG" id="ani:ANIA_07940"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN7940"/>
    <dbReference type="eggNOG" id="ENOG502QVEB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_739733_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AUU0"/>
    <dbReference type="OMA" id="INPGHRQ"/>
    <dbReference type="OrthoDB" id="10267976at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4100.10">
        <property type="entry name" value="2-methylcitrate dehydratase PrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036148">
        <property type="entry name" value="MmgE/PrpD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042183">
        <property type="entry name" value="MmgE/PrpD_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005656">
        <property type="entry name" value="MmgE_PrpD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045337">
        <property type="entry name" value="MmgE_PrpD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045336">
        <property type="entry name" value="MmgE_PrpD_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16943:SF8">
        <property type="entry name" value="2-METHYLCITRATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16943">
        <property type="entry name" value="2-METHYLCITRATE DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19305">
        <property type="entry name" value="MmgE_PrpD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03972">
        <property type="entry name" value="MmgE_PrpD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103378">
        <property type="entry name" value="2-methylcitrate dehydratase PrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MmgE/PrpD N-terminal" evidence="2">
        <location>
            <begin position="12"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="MmgE/PrpD C-terminal" evidence="3">
        <location>
            <begin position="222"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBF73564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="374" mass="40508" checksum="EAA5EA05092448A1" modified="2005-04-26" version="1">MADMNEPGVTRQFLSWVSSLTAHDIPEKIQKRVKYLTLDELGCAMVAAHLPWTEKATGIILDMEAEGSCPRVGPLPAALLNSMQIQGFEIDDWHSLAPVHSNAIVLPALFAGAANAKAKGTVTLGDSLLLSAIPYALTGLALGRRIRPRTGCGGCGKIDQPLRTSNLGCDWDSLHTGLWSYVCPVQQRYKAHAARIRGTKWSLCGSARSGGLPGIKNEYPDKMKDLSKIKKITFEMSESAYKHGGWPAQRPLTVTGAQMSCAYAAPVQLIDGQAEETGNAMSQRARVKFNDGTEVSKFVAAAKGFDLPLSNREIVDKFRTFTKGLIPEEMQRKIEETVLGLEGIEDISELEDLLAGLISSPFMGVSKRSSLYGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AUX3</accession>
    <accession>C8V4U8</accession>
    <name>Q5AUX3_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">VOC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_07907</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF73501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_681176.1">
        <property type="nucleotide sequence ID" value="XM_676084.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AUX3"/>
    <dbReference type="GeneID" id="2868959"/>
    <dbReference type="KEGG" id="ani:ANIA_07907"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN7907"/>
    <dbReference type="eggNOG" id="ENOG502S6T6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099500_1_0_1"/>
    <dbReference type="InParanoid" id="Q5AUX3"/>
    <dbReference type="OMA" id="FFRCGPG"/>
    <dbReference type="OrthoDB" id="16820at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="CDD" id="cd08354">
        <property type="entry name" value="VOC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050383">
        <property type="entry name" value="GlyoxalaseI/FosfomycinResist"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21366">
        <property type="entry name" value="GLYOXALASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21366:SF22">
        <property type="entry name" value="VOC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="9"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF73501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="162" mass="17854" checksum="F1A8EB9C87D02714" modified="2005-04-26" version="1">MATENNPPPLTHVLETCLYVRDIHASRKFYEDVLNIKPFMQSHRSACFSLGNTTLLLFQLGQTDADITTPSGVIPGHGPSAQIVAKLNAAKEGDGDIDSLKQHFCVAVQSTEDVAKWEAYLQKKGVPIISCTNWERGGKSIYFADLDGHLAEIASRGIWPHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AV93</accession>
    <accession>C8VDQ7</accession>
    <name>Q5AV93_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phytanoyl-CoA dioxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_07787</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF80106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_681056.1">
        <property type="nucleotide sequence ID" value="XM_675964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AV93"/>
    <dbReference type="GeneID" id="2869491"/>
    <dbReference type="KEGG" id="ani:ANIA_07787"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN7787"/>
    <dbReference type="eggNOG" id="ENOG502RN2Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049199_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AV93"/>
    <dbReference type="OMA" id="PRFCTYT"/>
    <dbReference type="OrthoDB" id="445007at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31630:SF7">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31630">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF80106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="342" mass="39239" checksum="225F3518EEAF8238" modified="2005-04-26" version="1">MSTTTMTTALPGRIFSHGTDVHYGDFRDDLLRNGFAVVKGAVPRDRALKYADEIYDWLEEFGLGFNRHDPSTIHKDHLPDINEKGMCLGYAISHESFTWAVRQEPGVIAAFEKVYDTPDLIVSFDSVNIGFPNRTDIKPNKPWPHQDQDPEKPGFRCLQGLVNLLPNGPDDGGLIVCKGAHLLSEEFHEAFKDEERIWSWYERSVYSSTKEWYGFTDAGLQWLRDKGCEWIKLTAEPGDLLLWDSRTPHYNLSSKTSQPRFAVYTCYMPVEDATTKQLQTKKMAFEETKMTTHWPNAMHVVDLPVHRNGELDPYDRKKPRKPVQLTDRGFKLTGIPYLEARA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2010-04-20" modified="2026-01-28" version="103" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AVP1</accession>
    <accession>C8VBY8</accession>
    <name>MAND_EMENI</name>
    <protein>
        <recommendedName>
            <fullName>Mannan endo-1,4-beta-mannosidase D</fullName>
            <ecNumber>3.2.1.78</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Endo-beta-1,4-mannanase D</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">manD</name>
        <name type="ORF">AN7639</name>
    </gene>
    <organism>
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Endo-1,4-mannanase, a crucial enzyme for depolymerization of seed galactomannans and wood galactoglucomannans.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>Random hydrolysis of (1-&gt;4)-beta-D-mannosidic linkages in mannans, galactomannans and glucomannans.</text>
            <dbReference type="EC" id="3.2.1.78"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.78"/>
    <dbReference type="EMBL" id="AACD01000130">
        <property type="protein sequence ID" value="EAA61825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF79796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_680908.1">
        <property type="nucleotide sequence ID" value="XM_675816.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AVP1"/>
    <dbReference type="SMR" id="Q5AVP1"/>
    <dbReference type="STRING" id="227321.Q5AVP1"/>
    <dbReference type="CAZy" id="GH5">
        <property type="family name" value="Glycoside Hydrolase Family 5"/>
    </dbReference>
    <dbReference type="GlyCosmos" id="Q5AVP1">
        <property type="glycosylation" value="3 sites, No reported glycans"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CBF79796">
        <property type="protein sequence ID" value="CBF79796"/>
        <property type="gene ID" value="ANIA_07639"/>
    </dbReference>
    <dbReference type="KEGG" id="ani:ANIA_07639"/>
    <dbReference type="eggNOG" id="ENOG502QS4Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031603_4_1_1"/>
    <dbReference type="InParanoid" id="Q5AVP1"/>
    <dbReference type="OMA" id="YFQLHDK"/>
    <dbReference type="OrthoDB" id="406631at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016985">
        <property type="term" value="F:mannan endo-1,4-beta-mannosidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046355">
        <property type="term" value="P:mannan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000076">
        <property type="entry name" value="Mannan endo-1,4-beta-mannosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045053">
        <property type="entry name" value="MAN-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31451">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31451:SF57">
        <property type="entry name" value="BETA-1,4-ENDOGLUCANASE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26410">
        <property type="entry name" value="GH5_mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0326">Glycosidase</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000393711" description="Mannan endo-1,4-beta-mannosidase D">
        <location>
            <begin position="23"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="299"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="329"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="4">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="4">
        <location>
            <position position="273"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="4">
        <location>
            <position position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="B4XC07"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="3">
        <source>
            <dbReference type="UniProtKB" id="Q99036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="4"/>
    <evidence type="ECO:0000305" key="5"/>
    <sequence length="381" mass="41603" checksum="2D1871678CF69515" modified="2005-04-26" version="1" precursor="true">MKHLLSLVCTLGAATLAASAAAEAGSMPSANGLDFVIDGEASYFAGSNAYWLSFLTNNADVDLALDHFAESGLKILRIWGFSDVTAEPSDNKVYFQLHQNGSSTVNTGPNGLERLDYIISGAEKRGIKLVIPLVNYWDDFGGMNAYISAYGGDKPGWYTNDKIQAAYHAYVKAVVSRYVDSPAIFAWELANEPRCSGCDTSIINQWATKTSSFIKSLDPNHMVAMGDEGMGLPGDSNYPYSYYEGNDFALNLAIPDIDFGTLHLYTTDWGVSNNSWGNKWVQDHAAVCKSAGKPCLFEEYGMKGNHCTYELAWQKTALATPGMAADLFWQFGENLSSGQTHNDKYTVYYGSNEWKCVVSDHVAAVAVRRYRLPVGGGQHGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AVW9</accession>
    <accession>C8VBP7</accession>
    <name>Q5AVW9_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">NADH-ubiquinone oxidoreductase 12 kDa subunit, putative (AFU_orthologue AFUA_2G14905)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ANIA_07561</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF79632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_680830.1">
        <property type="nucleotide sequence ID" value="XM_675738.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AVW9"/>
    <dbReference type="STRING" id="227321.Q5AVW9"/>
    <dbReference type="GeneID" id="2869757"/>
    <dbReference type="KEGG" id="ani:ANIA_07561"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN7561"/>
    <dbReference type="eggNOG" id="ENOG502SBS6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_142967_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AVW9"/>
    <dbReference type="OMA" id="GYQKNDP"/>
    <dbReference type="OrthoDB" id="10252718at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039993">
        <property type="entry name" value="NDUFB10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13094:SF1">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13094">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE PDSW SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBF79632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="103" mass="11876" checksum="6E68917F67E46D43" modified="2005-04-26" version="1">MPTPESAAFLAKKPTVPPTYDGVDFEDNVAVHNARDAIIREQWVRSMMSRLVGEELGKCYAREGVNHLEKCGKLREKYFELLSERKIKGYLFEEKNYFATKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AWD7</accession>
    <accession>C8VCF2</accession>
    <name>Q5AWD7_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ricin B lectin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_07393</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
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            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
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    <dbReference type="RefSeq" id="XP_680662.1">
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    <dbReference type="AlphaFoldDB" id="Q5AWD7"/>
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    <dbReference type="KEGG" id="ani:ANIA_07393"/>
    <dbReference type="eggNOG" id="ENOG502SH6C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103467_0_0_1"/>
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    <dbReference type="OMA" id="FDRKCAA"/>
    <dbReference type="OrthoDB" id="4426724at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030175735" description="Ricin B lectin" evidence="1">
        <location>
            <begin position="19"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF78472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="185" mass="20060" checksum="1EB71E43A92319EA" modified="2005-04-26" version="1">MLASLVAAVLATTSCASAALTWSLDKSANPSDDESDAYSRIEAAMEAAVARYARLGDASKSIYVYYVPGVPTAEASYDGTIRFGSDRAYMNERTALHEISHTLGVGQTAAFDQQCADGDWPTALPLLRSWDGADAVINCGGGHFWPYGLNYNDEWSETNGDRNLLTAFIPPYYVSRIPENNCVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AWG8</accession>
    <accession>C8VCI8</accession>
    <name>Q5AWG8_EMENI</name>
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        <recommendedName>
            <fullName evidence="4">C2H2-type domain-containing protein</fullName>
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    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_07362</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF78542.1"/>
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    </dbReference>
    <dbReference type="RefSeq" id="XP_680631.1">
        <property type="nucleotide sequence ID" value="XM_675539.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AWG8"/>
    <dbReference type="STRING" id="227321.Q5AWG8"/>
    <dbReference type="GeneID" id="2869796"/>
    <dbReference type="KEGG" id="ani:ANIA_07362"/>
    <dbReference type="eggNOG" id="ENOG502SHF7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_314490_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AWG8"/>
    <dbReference type="OMA" id="CANICLQ"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35391:SF7">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35391">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="568"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="771"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="784"/>
            <end position="793"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF78542.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="116" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AWN0</accession>
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        <submittedName>
            <fullName evidence="7">PHD finger domain protein, putative (AFU_orthologue AFUA_2G16810)</fullName>
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        <name evidence="7" type="ORF">ANIA_07300</name>
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    <organism evidence="7 8">
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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    <reference evidence="8" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
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            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF78667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_680569.1">
        <property type="nucleotide sequence ID" value="XM_675477.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AWN0"/>
    <dbReference type="STRING" id="227321.Q5AWN0"/>
    <dbReference type="GeneID" id="2870174"/>
    <dbReference type="KEGG" id="ani:ANIA_07300"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN7300"/>
    <dbReference type="eggNOG" id="KOG4299">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_336144_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AWN0"/>
    <dbReference type="OMA" id="CVNSFHF"/>
    <dbReference type="OrthoDB" id="5876363at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032221">
        <property type="term" value="C:Rpd3S complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd15532">
        <property type="entry name" value="PHD2_CHD_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15534">
        <property type="entry name" value="PHD2_PHF12_Rco1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000748">
        <property type="entry name" value="PHD finger domain protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052819">
        <property type="entry name" value="Chromatin_regulatory_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47636">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATORY PROTEIN RCO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47636:SF1">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATORY PROTEIN RCO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="6">
        <location>
            <begin position="450"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="133"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="323"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="59"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="71"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="150"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="389"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBF78667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="841" mass="92363" checksum="789A19E3581D0070" modified="2005-04-26" version="1">MARNLRSSSHARSNDSRPSTPVPHTANMASPFTESTRPRKQRRTGRSSRVGTDSLRDTPVSSQSQSVQPQESATNGVSGTELNGHFADWIEPEPRAPVPSYLDTPWSNVSNAHNPVLGTMRPLGALPTTADRRKAGLAPSHPGTPSIPAVKEKQPVSEGEKKDDSPPTLLTPAEEQAPELILPRPTIEEDLAAFTILPVPNSIDADVDTLKAAVESALHLASDANNRLVIKGLLRMWEKCGNDPYVLRILDGVCQETPGSPQRSMFQKAMRTVLGELEAQEMARTEPGAPPVLGRARSASSVSTLSSAKSLDAETYAPVPVVAATSAPRPKKGKQSKNSTQKKTAPAVDFQRQRAVENPEFSEEAIQAKKSRLRKSLPKIATSESGIRSSLTSNPPSNFSSPGPIAANLDISVSRNTGAHRERSESVASSDAGDNRRLTPSLTDEPAENNDFCRQCEKSGRLLCCDGCVYSYHFSCLNPPLDPANPPEGDWFCPKCSVSKSLNTLLGGMEKTPGRDFALPNKIRDFFAGVRTGDDGKYEEVASLPRINPRAARGSRTGRYDDPFLLRITDAKGKLIVCVKCGQTTNGRRPIIQCDFCPCAFHMDCLDPPLAVPPTQRVGSDRLYHTWMCPNHALHDMCYPVRDEEGYETMKRIRRPKNPRFIDVEVLPENEEEENLEDEEKEGITYRVSEKGIKLDFIERVKRENETAAAKKAAEKMYFEYAKSKVDAITSEAKAFFESQKPADDTTAAILNSRTDVEREAAANLILFAQSNQVIWQNEQNGQINLLIDQLKANAPKNLPAPEDEISSLRALQKLIEQRISALQPKQKTKNAYSSEVQPTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AX20</accession>
    <accession>C8VD65</accession>
    <name>Q5AX20_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ANIA_07160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF78957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_664764.1">
        <property type="nucleotide sequence ID" value="XM_659672.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AX20"/>
    <dbReference type="GeneID" id="2870076"/>
    <dbReference type="KEGG" id="ani:ANIA_07160"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN7160"/>
    <dbReference type="HOGENOM" id="CLU_1165801_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AX20"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF78957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="238" mass="27506" checksum="009920E22D1917F3" modified="2005-04-26" version="1">MRISEIDEVVDQVVRPCQKAIMKAITSLSLAALLRAYQLEMPKSIQRENCGREQYEVQEYLCDCSPILRGHENENITQVPAVVQNHLHWSPANTRSSSWEASRSMNIVPIVRGTGRKYPVTSSCCQSEATSYRELYTQVNSNSTLTYPFSEILAPFVSASRSYYRRWLFDLNRKNDALGTFQCSKETVRVENDYSTSRKAVKWYKTGQKCEEFALWARMHPSHTVFLFLEGIRLCFVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AY76</accession>
    <accession>C8V1Z5</accession>
    <name>Q5AY76_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GPI anchored protein, putative (AFU_orthologue AFUA_7G00450)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_06754</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF71393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_664358.1">
        <property type="nucleotide sequence ID" value="XM_659266.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AY76"/>
    <dbReference type="GeneID" id="2870243"/>
    <dbReference type="KEGG" id="ani:ANIA_06754"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN6754"/>
    <dbReference type="eggNOG" id="ENOG502SCCN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074173_1_0_1"/>
    <dbReference type="InParanoid" id="Q5AY76"/>
    <dbReference type="OMA" id="MDISYSY"/>
    <dbReference type="OrthoDB" id="4991875at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40640">
        <property type="entry name" value="ANCHORED GLYCOPROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40640:SF2">
        <property type="entry name" value="GPI ANCHORED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030175747" evidence="2">
        <location>
            <begin position="18"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF71393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="215" mass="20927" checksum="2CDA60BD2E8DF7F7" modified="2005-04-26" version="1">MMLSSLLLPALASLAIAESIVTSMFIFGADRQPLAASIMGNDASATTYSINCPPGTDSNDCGMGPGMTVIAADETTTYMMNDGDNFKFTAECSVGKSIADCTASAGGPDANFPGVETATEEVSYIPVTVTAGSVTSTGGSTATSTSTSSSSNGSSASEEATAAGSASASRASETASQTAEETAAQPSETGAAVRVTGVVGLVVGGAAVALMGAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="131" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AYB5</accession>
    <accession>C8V1Q3</accession>
    <name>Q5AYB5_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cell pattern formation-associated protein stuA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Stunted protein A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ANIA_06715</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF71308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_664319.1">
        <property type="nucleotide sequence ID" value="XM_659227.1"/>
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    <dbReference type="AlphaFoldDB" id="Q5AYB5"/>
    <dbReference type="STRING" id="227321.Q5AYB5"/>
    <dbReference type="GeneID" id="2870342"/>
    <dbReference type="KEGG" id="ani:ANIA_06715"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN6715"/>
    <dbReference type="eggNOG" id="ENOG502QPWC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009666_1_1_1"/>
    <dbReference type="InParanoid" id="Q5AYB5"/>
    <dbReference type="OMA" id="HHIAMMA"/>
    <dbReference type="OrthoDB" id="6718656at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030907">
        <property type="term" value="C:MBF transcription complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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    <dbReference type="GO" id="GO:0033309">
        <property type="term" value="C:SBF transcription complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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    <dbReference type="GO" id="GO:0048315">
        <property type="term" value="P:conidium formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
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        <property type="project" value="GO_Central"/>
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    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Ankyrin repeat-containing domain"/>
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    <dbReference type="Gene3D" id="3.10.260.10">
        <property type="entry name" value="Transcription regulator HTH, APSES-type DNA-binding domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Ankyrin_rpt"/>
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        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
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        <property type="entry name" value="HTH_APSES_sf"/>
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        <property type="entry name" value="KilA/APSES_HTH"/>
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    <dbReference type="InterPro" id="IPR051642">
        <property type="entry name" value="SWI6-like"/>
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    <dbReference type="InterPro" id="IPR003163">
        <property type="entry name" value="Tscrpt_reg_HTH_APSES-type"/>
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        <property type="entry name" value="ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43828:SF3">
        <property type="entry name" value="CHROMO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04383">
        <property type="entry name" value="KilA-N"/>
        <property type="match status" value="1"/>
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    <dbReference type="SMART" id="SM01252">
        <property type="entry name" value="KilA-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF54616">
        <property type="entry name" value="DNA-binding domain of Mlu1-box binding protein MBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51299">
        <property type="entry name" value="HTH_APSES"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-0183">Conidiation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0749">Sporulation</keyword>
    <feature type="domain" description="HTH APSES-type" evidence="8">
        <location>
            <begin position="100"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="283"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="56"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="201"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="284"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00019309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBF71308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="888" mass="98132" checksum="3F4AA3E776BA15CE" modified="2005-04-26" version="1">MTTSNHHQQRPSLSMSYSQGSIGSANGMSFSQSQMSSLNASQSVASTPRATPPPKSSQQSAMSFNYSNGLPNGARASFSGFEDMNGYGTMIYHEEFKPQIYRAVYSNVSVYEMEVNGVAVMKRRSDGWLNATQILKVAGVVKARRTKTLEKEIAAGEHEKVQGGYGKYQGTWVNYQRGVELCREYHVEELLRPLLEYDMNPNGTAASGQDSLDTPTKEQAMAAQRKRLYSGMENRSMSQPQQGTFFQNISRTAATAVNAMSKARFESPAARGGDSRRLSVIRKPSQQMGSQDAQPPFGSQQSFYSAASDSGFASNIPTNGRYAPQDAMSFEQEEPMEPPRKRIRSSQAFSLPIDGTSMSMSEPTPTEPNDSFYQDMEPLHHIDEGRHGLDPLPPATTPERFQKMKLIMTLFLDKTTKDFSTHPALIQLSGEDLEVPLDEYRNNALHWAAMLARMPLVYALVKKGVNIARLNGAGETALQKAVGTRNNLDYRSFPRLLQVLAPTIDMVDRSGRTILHHIAVMAATGHGGHVSAKHYLEALLEFIVRHGGTSLNQQSNGTASQPGMPLSNEVITLGRFISEIVNLRDDQGDTALNLAGRARSVLVPQLLEVGADPHIPNHTGLRPADYGVGVDMVDGSSQPAGSRSDTFLAQLAKTRKEILEATTAQVTAIVQETLGTFDKELAASLTSKQEKFDHWHAKIRESAKARQIEQKQLDELKRRSIDRTETSRRLKNLEKSSTDLLEAHKEILTNLGDTSKPVSLGDADQESGFEIAEFEALFPETFDPASGFSEAQIAYLRKLPSAEILEQRVSCYRAFNKETLDEIDALRSKNVVLGQNYRRMVMACTGWSAEQVDEAAEGLTQCVKELNDNPVPEDEAIEILMRDRGQDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AYG2</accession>
    <accession>C8V1F7</accession>
    <name>Q5AYG2_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ANIA_06668</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family. Isoflavone reductase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF71213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_664272.1">
        <property type="nucleotide sequence ID" value="XM_659180.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AYG2"/>
    <dbReference type="GeneID" id="2870450"/>
    <dbReference type="KEGG" id="ani:ANIA_06668"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN6668"/>
    <dbReference type="eggNOG" id="ENOG502RXEE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044876_0_2_1"/>
    <dbReference type="InParanoid" id="Q5AYG2"/>
    <dbReference type="OMA" id="HTVLSFM"/>
    <dbReference type="OrthoDB" id="10000533at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF4">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="4">
        <location>
            <begin position="3"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBF71213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="317" mass="35157" checksum="C6FCF4C105733E99" modified="2005-04-26" version="1">MVKIAIAGGTSGVGQEVIDALVETKRHEVLLLSRKDAPSIILPDSITWIKTDYAETEQLADILKGVHTVLSFVIEQDSETSPVQRRLIDASIAAGVKRFAPSEWASSTFDHLPWYTYKSSIRTYLSEVNREKQILEYTLFQPGLFTNYLAAPYKTTPHISLLEMPIDFFHRRAILVEGAENAPITLTTIADFKAVFVRAIEYQGAWPVVSGIAGSTLTLGELIALGERVRGGKFSIERVKREDFLAGNWETSWVPRNEHPSIPKEMVDEFARPATKGISLGLADGAFAIQGVWNGNLDGFAFEGAEEFLGRIWKGKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="99" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AZ63</accession>
    <accession>C8V0H1</accession>
    <name>Q5AZ63_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter, putative (AFU_orthologue AFUA_5G00430)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ANIA_06417</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF69513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_664021.1">
        <property type="nucleotide sequence ID" value="XM_658929.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AZ63"/>
    <dbReference type="GeneID" id="2871314"/>
    <dbReference type="KEGG" id="ani:ANIA_06417"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_13_3_1"/>
    <dbReference type="InParanoid" id="Q5AZ63"/>
    <dbReference type="OMA" id="PTRRNKH"/>
    <dbReference type="OrthoDB" id="5215911at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF50">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G00430)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="181"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="301"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="347"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="390"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="48"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBF69513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="452" mass="50227" checksum="6AD4F0282CED0196" modified="2005-04-26" version="1">MESQTLFHEPPGTVTIEDLHHGEEAVVVLKPTPSEDPNDPLNWSKLRKLVNFALASFYTLATFVLLDIGTVIWVQLNAELDISWSNLNNSFALNLAGLAIGCILIVPFAIKYGRRSIYILSSVVQLATAIWQAKMNTTAELLAINALNGLAGAVSEAIVQMTIVDIFFVHQRASANAFYNFMVNTGAYLAPVAAGYCATAQGWRWIWWWTSIMLAINTLLFLLAFEETKYIPILFGQAREHVHTDSKARYEQPGMKSSGSTQATGELAMETEAYRRKPYRERLALITKTDNPIWENVKRPLVVLVSFPAVTFTAFVWGCFLSWFSIIATTQSSYLALPPYNYNSSQIGLFNLPPFIGGVIGGVLSGPVNDWYVLWRAKRSNGVFEPETRLHMSLPAIIATPIGLLVFGIGLAREVCSSSLLPLCSAYPDEAVYCDGHDADDYPNDRIWYFGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="107" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AZ90</accession>
    <accession>C8V0P6</accession>
    <name>Q5AZ90_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">homogentisate 1,2-dioxygenase</fullName>
            <ecNumber evidence="4">1.13.11.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">ANIA_06390</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="16">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 4/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the homogentisate dioxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.5" evidence="4"/>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF69562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_663994.1">
        <property type="nucleotide sequence ID" value="XM_658902.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AZ90"/>
    <dbReference type="STRING" id="227321.Q5AZ90"/>
    <dbReference type="GeneID" id="2871289"/>
    <dbReference type="KEGG" id="ani:ANIA_06390"/>
    <dbReference type="eggNOG" id="KOG1417">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027174_0_1_1"/>
    <dbReference type="InParanoid" id="Q5AZ90"/>
    <dbReference type="OMA" id="PGTIPHG"/>
    <dbReference type="OrthoDB" id="1689029at2759"/>
    <dbReference type="UniPathway" id="UPA00139">
        <property type="reaction ID" value="UER00339"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004411">
        <property type="term" value="F:homogentisate 1,2-dioxygenase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006572">
        <property type="term" value="P:L-tyrosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07000">
        <property type="entry name" value="cupin_HGO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000034">
        <property type="entry name" value="Homogentisate 1,2-dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046451">
        <property type="entry name" value="HgmA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046452">
        <property type="entry name" value="HgmA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005708">
        <property type="entry name" value="Homogentis_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01015">
        <property type="entry name" value="hmgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11056">
        <property type="entry name" value="HOMOGENTISATE 1,2-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11056:SF4">
        <property type="entry name" value="HOMOGENTISATE 1,2-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04209">
        <property type="entry name" value="HgmA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20510">
        <property type="entry name" value="HgmA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="9 12" id="KW-0408">Iron</keyword>
    <keyword evidence="5 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-0585">Phenylalanine catabolism</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0828">Tyrosine catabolism</keyword>
    <feature type="domain" description="Homogentisate 1,2-dioxygenase N-terminal" evidence="14">
        <location>
            <begin position="9"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="Homogentisate 1,2-dioxygenase C-terminal" evidence="13">
        <location>
            <begin position="288"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="299"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="342"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="348"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="357"/>
        </location>
        <ligand>
            <name>homogentisate</name>
            <dbReference type="ChEBI" id="CHEBI:16169"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="378"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="378"/>
        </location>
        <ligand>
            <name>homogentisate</name>
            <dbReference type="ChEBI" id="CHEBI:16169"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR605708-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR605708-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF20510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CBF69562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="462" mass="51448" checksum="2FF61828FD8CBBC9" modified="2005-04-26" version="1">MPNAQYSGYQAGFGNSFESEAVPGTIPHGQNSPRNVRFGLYAEQVTATAFIAPRHCNKKAWLYRARPAAELGANSVLFQTELPDNKDTECSFLPLNPRIHVSPTQLAWHPFDIEESETDFVAGLKTVAGSGDPTLREGIATHVYTANKSMTKRAFVNSDGEFLIVPQQGALDIQTEFGPLFVQPGEIVVIQRGLRFRVELPDGPSRGYILEIWGSQFELPELGPLGANGLANARDFLYPTAKYEVVKEPWEIIYKLGGKFFKSTQQHSPFDVVAWHGNYVPYKYDLTKFVNVGSISVDHIDPSIFCVLTAKSRDLNAPLADVLIFSPRWDVASHTYRPPYYHRNAASELMGLIYGDYGGRSDAFKPGSISFECGMVPHGVAYEEFSAATAGETDPPAMRISEGSIAFMFESSRPFTITDFAWKSEKRHEHEPKMWDNLVDHFSEHAKEVEEILAAKAKGLRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="108" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B0J3</accession>
    <accession>C8V3I3</accession>
    <name>Q5B0J3_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cupin type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ANIA_05937</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the germin family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF70529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_663541.1">
        <property type="nucleotide sequence ID" value="XM_658449.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B0J3"/>
    <dbReference type="STRING" id="227321.Q5B0J3"/>
    <dbReference type="GeneID" id="2870821"/>
    <dbReference type="KEGG" id="ani:ANIA_05937"/>
    <dbReference type="eggNOG" id="ENOG502QSRM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061239_1_0_1"/>
    <dbReference type="InParanoid" id="Q5B0J3"/>
    <dbReference type="OMA" id="EFNPDCG"/>
    <dbReference type="OrthoDB" id="1921208at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02241">
        <property type="entry name" value="cupin_OxOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000150">
        <property type="entry name" value="Spherulin, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006045">
        <property type="entry name" value="Cupin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001929">
        <property type="entry name" value="Germin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31238">
        <property type="entry name" value="GERMIN-LIKE PROTEIN SUBFAMILY 3 MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00190">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00325">
        <property type="entry name" value="GERMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00835">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010270423" description="Cupin type-1 domain-containing protein" evidence="6">
        <location>
            <begin position="23"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Cupin type-1" evidence="7">
        <location>
            <begin position="94"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBF70529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="274" mass="28848" checksum="E8C10E3712028458" modified="2005-04-26" version="1">MHFTQFISTSLSISLLAGSALAIPTGSYSHSNSTDGSGSNIDSLLPPIVPVNPRSGNKELITSLLLAPTQADRAALLTEPGDYIFDFNEGGAPEGAEAKGLGGFSIAAHSKTFPALIGNGASMTLGFLGPCGMNTPHVHNRATELNVVVKGRLVTNFILENGVSPVENTLDLYQMAVFPQGSIHQEFNPDCGETVFVAGFNDADPGVSQVAQGLFGLRGDVVQATLGGIQTFNGQDIESFREMIPKNVALGIEACLAKCGLQKNEKRELKELMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="111" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B0M6</accession>
    <accession>C8UZU7</accession>
    <name>Q5B0M6_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acyl CoA binding protein family (AFU_orthologue AFUA_2G11060)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ANIA_05904</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ACBP family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF70599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_663508.1">
        <property type="nucleotide sequence ID" value="XM_658416.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B0M6"/>
    <dbReference type="FunCoup" id="Q5B0M6">
        <property type="interactions" value="405"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5B0M6"/>
    <dbReference type="GeneID" id="2870819"/>
    <dbReference type="KEGG" id="ani:ANIA_05904"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN5904"/>
    <dbReference type="eggNOG" id="KOG0817">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_150174_0_0_1"/>
    <dbReference type="InParanoid" id="Q5B0M6"/>
    <dbReference type="OMA" id="MEKPGMF"/>
    <dbReference type="OrthoDB" id="346910at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036042">
        <property type="term" value="F:long-chain fatty acyl-CoA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.80.10:FF:000051">
        <property type="entry name" value="Acyl CoA binding protein family (AFU_orthologue AFUA_2G11060)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000582">
        <property type="entry name" value="Acyl-CoA-binding_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035984">
        <property type="entry name" value="Acyl-CoA-binding_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310:SF62">
        <property type="entry name" value="ACYL-COA BINDING PROTEIN 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310">
        <property type="entry name" value="ACYL-COA-BINDING PROTEIN, ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00887">
        <property type="entry name" value="ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00689">
        <property type="entry name" value="ACOABINDINGP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47027">
        <property type="entry name" value="Acyl-CoA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51228">
        <property type="entry name" value="ACB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACB" evidence="3">
        <location>
            <begin position="60"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBF70599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="144" mass="15563" checksum="C915B89481BFB157" modified="2005-04-26" version="1">MSVPTFTAALTASQNKEKYSAKVQELAAAINADALSSAIEAILSGGDDATVSDAEQSKALTAGFEYATELVKELKSSPGNDDKLKLYAFFKRSKNEEPAAPGAFSFEAKYKYNAWKEIKDISQQRAQALYIQKVNALLESIGTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="131" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B1X6</accession>
    <accession>C8VGG6</accession>
    <name>Q5B1X6_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Endochitinase B</fullName>
            <ecNumber evidence="3">3.2.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Chitinase B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">ANIA_05454</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="17">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 18 family. Chitinase class V subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="3"/>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF81882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_663058.1">
        <property type="nucleotide sequence ID" value="XM_657966.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B1X6"/>
    <dbReference type="FunCoup" id="Q5B1X6">
        <property type="interactions" value="571"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5B1X6"/>
    <dbReference type="CAZy" id="GH18">
        <property type="family name" value="Glycoside Hydrolase Family 18"/>
    </dbReference>
    <dbReference type="GeneID" id="2871749"/>
    <dbReference type="KEGG" id="ani:ANIA_05454"/>
    <dbReference type="eggNOG" id="KOG2806">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002833_1_3_1"/>
    <dbReference type="InParanoid" id="Q5B1X6"/>
    <dbReference type="OMA" id="FYYCSGG"/>
    <dbReference type="OrthoDB" id="76388at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004568">
        <property type="term" value="F:chitinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06548">
        <property type="entry name" value="GH18_chitinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.10:FF:000005">
        <property type="entry name" value="Endochitinase B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000095">
        <property type="entry name" value="Endochitinase B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF317">
        <property type="entry name" value="CHITINASE 12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010295876" description="Endochitinase B" evidence="14">
        <location>
            <begin position="19"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="15">
        <location>
            <begin position="68"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="39"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00072345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00076373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CBF81882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="463" mass="51584" checksum="B6785AACD149BDE9" modified="2005-04-26" version="1">MKLPILFFSTIFLVLAQAATLPPLYHIYRSLNSTSNNNTNYAHNNTTGRGPGYSPGPISDPSSGQREYRSMAYFVNWAIYARHHNPQDLPVSHLTHILYAFANVRPETGEVYLSDTYSDIEKHYPTDSWNDQGNDNVYGCVKQLFLLKQQNRHLKVLLSVGGWTYSKNFARMAATEEGRRLFAKSAVELMGDLGMDGVDVDWEYPENDDQASDFVELLRETREELDRYAADNDSDKPFLLSVASPAEPGPSKYTTLHLSSMDRYLDFWNLMAYDYSGSWDTITGHNANLFASRQNPASTPFNTHTAVTAYLAAGIPASKINLGMPLYGRSFTHTDGPGTEFEGVGYEGSFEAGVWDYKALPKPGAEVVEVEEIAASFSYDEDKKEVISYDNVGVVRHKGVYLMRLGMGGGMWWESSGDREVGSGGSLIETLVDTLGGVNALDKSENQLEYPASRFENLRNGFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B1Y4</accession>
    <accession>C8VGH4</accession>
    <name>Q5B1Y4_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_05446</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF81895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_663050.1">
        <property type="nucleotide sequence ID" value="XM_657958.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B1Y4"/>
    <dbReference type="GeneID" id="2871737"/>
    <dbReference type="KEGG" id="ani:ANIA_05446"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN5446"/>
    <dbReference type="HOGENOM" id="CLU_493446_0_0_1"/>
    <dbReference type="InParanoid" id="Q5B1Y4"/>
    <dbReference type="OMA" id="HPKRPYE"/>
    <dbReference type="OrthoDB" id="4509259at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="54"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="144"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="264"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="328"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="356"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="396"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="433"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="446"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="488"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="515"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="554"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF81895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="586" mass="59485" checksum="B47EFC66BEB5D0BB" modified="2005-04-26" version="1">MAKKGGKGKKGKKSGSTATAAAATNKAAEPVAAAVPDTSVEENVAKSETEVEQAPTETVEAPTSTPATAAPETTTETATSAPEAPPIAAAATENKDEVPVPAAKDAPIEEAVEAVPKTEAKEDELKETAVAPETTAEEPKVTTETETETATAPLTNPEIVAATTTLPERLKESESHEETSTKRPLETPIFTEKEHKPAKIAKFEDESVAEPTAAETPVQSENVGNAAETDLPNEAGKVPPQMVPGLGAHPADKPLADFETPGLSVVSSNVVNNKEATPAVETSEEPKAVEAIATSEVPTAQKETIPSDAKAPEPAKSENAPAEEKPLTTTATTTAVDSTTENAKEEAKALPKTDEPAVTQPTAAAAAVGAGTSEAPATLEGPKETPSAQKEPSVVGKTTADATTGPAATVGTTAQEESKTVPSAQQEPAVSKPTAAAAAATAAPTGDDKQKVEEPSKSKLETPEVTKPPAAVTPPEKAHAAPVVSEATGATSSAADKPAASNQTQPEKPSGLSESAAAARAATQKSQQAKAAESQSADKAQSDGAAQSEEGKTTTEQTAAAQSETSKADKRKSGFFGWLKRKVKGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B338</accession>
    <accession>C8V842</accession>
    <name>Q5B338_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_05042</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF76219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_662646.1">
        <property type="nucleotide sequence ID" value="XM_657554.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B338"/>
    <dbReference type="GeneID" id="2872840"/>
    <dbReference type="KEGG" id="ani:ANIA_05042"/>
    <dbReference type="HOGENOM" id="CLU_1927567_0_0_1"/>
    <dbReference type="InParanoid" id="Q5B338"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF76219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="131" mass="14646" checksum="E9A0F12290D86E72" modified="2005-04-26" version="1">MPLTRSTSQTKEVLSREWRRISFPKVILVLQLQDDYPSLRYANDDSSYKTATPAHPAQPPKHDYQQGPKVQQARLDGTLLDSIPPLLQEVFGPIPMLIFNNEVTNARSSVQEPSQICLGVLGVEALSSFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B3W8</accession>
    <accession>C8VAR0</accession>
    <name>Q5B3W8_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_04762</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF76839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_662366.1">
        <property type="nucleotide sequence ID" value="XM_657274.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B3W8"/>
    <dbReference type="GeneID" id="2872564"/>
    <dbReference type="KEGG" id="ani:ANIA_04762"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN4762"/>
    <dbReference type="eggNOG" id="ENOG502S6NX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_136890_0_0_1"/>
    <dbReference type="InParanoid" id="Q5B3W8"/>
    <dbReference type="OMA" id="MASMITR"/>
    <dbReference type="OrthoDB" id="3141857at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039965">
        <property type="entry name" value="C3H7.08c"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40466">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40466:SF1">
        <property type="entry name" value="FUNGAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF76839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="144" mass="16296" checksum="1AEE7E1B215ACA22" modified="2005-04-26" version="1">MSSIAAMASRRAFARQALFRAPVRRAYSSKMEESTLDKAPKRDPELYVLLGVMSGAFLIAGWYFGKKPTSVTSESNVRIPDSSMPWERDDDGKIYKYQYHPGGDKSQPLRNAPSALNTVIVPNVTLPVDLHERFNKYGKEEYDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="115" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B5V7</accession>
    <accession>C8V5G5</accession>
    <name>Q5B5V7_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ANIA_04073</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS12 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF74761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_661677.1">
        <property type="nucleotide sequence ID" value="XM_656585.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B5V7"/>
    <dbReference type="FunCoup" id="Q5B5V7">
        <property type="interactions" value="956"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5B5V7"/>
    <dbReference type="GeneID" id="2873492"/>
    <dbReference type="KEGG" id="ani:ANIA_04073"/>
    <dbReference type="eggNOG" id="KOG3406">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_110343_0_0_1"/>
    <dbReference type="InParanoid" id="Q5B5V7"/>
    <dbReference type="OMA" id="CAEHQIP"/>
    <dbReference type="OrthoDB" id="10249311at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990145">
        <property type="term" value="P:maintenance of translational fidelity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000530">
        <property type="entry name" value="Ribosomal_eS12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047860">
        <property type="entry name" value="Ribosomal_eS12_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11843">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00972">
        <property type="entry name" value="RIBSOMALS12E"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01189">
        <property type="entry name" value="RIBOSOMAL_S12E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="6">
        <location>
            <begin position="34"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBF74761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="183" mass="20303" checksum="E76D762E86B4EEBD" modified="2005-04-26" version="1">MSDGEETQSNPPVAAEEVEVPAESGAGGQMSVLDALKGVLRIALIHDGLARGLREAAKALDRRQAHMCVLNEGCEEEAYKKLVVALCSEHKIPLIKVPDGKMLGEWVGLCTYLEPPKNNYQRTLEELQKFTIGRMLTVIYLTGQLDREGNARKVVNCSCVVVKDWGEESQERSVLLNYFQTEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="123" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B6A4</accession>
    <accession>C8V651</accession>
    <name>Q5B6A4_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mitochondrial division protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ANIA_03926</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in mitochondrial fission. Acts as an adapter protein required to form mitochondrial fission complexes. Formation of these complexes is required to promote constriction and fission of the mitochondrial compartment at a late step in mitochondrial division.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the WD repeat MDV1/CAF4 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF75078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_661530.1">
        <property type="nucleotide sequence ID" value="XM_656438.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B6A4"/>
    <dbReference type="STRING" id="227321.Q5B6A4"/>
    <dbReference type="GeneID" id="2873346"/>
    <dbReference type="KEGG" id="ani:ANIA_03926"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN3926"/>
    <dbReference type="eggNOG" id="KOG0266">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_57_1_1"/>
    <dbReference type="InParanoid" id="Q5B6A4"/>
    <dbReference type="OMA" id="DCVRLWN"/>
    <dbReference type="OrthoDB" id="674604at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000510">
        <property type="entry name" value="WD repeat protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059122">
        <property type="entry name" value="Beta-prop_WDR5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847:SF637">
        <property type="entry name" value="WD REPEAT DOMAIN 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25175">
        <property type="entry name" value="Beta-prop_WDR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="WDR5-like beta-propeller" evidence="9">
        <location>
            <begin position="172"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="172"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="214"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="257"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="299"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="342"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="438"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="474"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="80"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="112"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="131"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="149"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="497"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00043913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF25175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBF75078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="522" mass="57512" checksum="BE01D7E64D33B805" modified="2005-04-26" version="1">MEHPSKRRRLTPSPPPISSPIETSSDELAAGSDHDQERRRVSLNAYPPKRPYPRSRSFSSSESPDELAMDADVYWRSRNRGRDDSPWARSDEENDENEADEEENENEDDEHDNMNGDDNGREANGSRERDLDEMDTVGENEPETDPDRSPTPVPPPPPPKPESVNYRQKFLLRGHLRGVSAVRFSPDASMIASGGADGAVKVWAASTGKLIYTFEGHLAGISTISWSPDGATIASGSDDKTIRLWNVLTGKAHPTPFIGHHNYVYAIAFSPKGNMLVSGSYDEAVFLWDVRSARVMKSLPAHSDPVSGIDVVWDGTLIASCATDGLVRIWDTSTGQCLRTLVHEDNPPVSSVKFSPNGKYVLAWTLDDCVRLWDYVEGRCLKTYQGHSNKKYSLSGAFGVYGQSIPGRTPGYAFAVSGSEDGAILCWDVVTKKVLQRIEAHDGVVLGVDTCSTGEGRFMVSCGLDGTVRVWEEVGPEREPEPEPEPEPGQCPDQDQDQGRDWDMDSEMREAGELAVETRDPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B6F5</accession>
    <accession>C8V6D5</accession>
    <name>Q5B6F5_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA ligase D 3'-phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_03875</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF75191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_661479.1">
        <property type="nucleotide sequence ID" value="XM_656387.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B6F5"/>
    <dbReference type="GeneID" id="2873299"/>
    <dbReference type="KEGG" id="ani:ANIA_03875"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN3875"/>
    <dbReference type="eggNOG" id="ENOG502SF29">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040687_0_0_1"/>
    <dbReference type="InParanoid" id="Q5B6F5"/>
    <dbReference type="OMA" id="SIHQRKW"/>
    <dbReference type="OrthoDB" id="2588098at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014144">
        <property type="entry name" value="LigD_PE_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39465:SF1">
        <property type="entry name" value="DNA LIGASE D 3'-PHOSPHOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39465">
        <property type="entry name" value="DNA LIGASE D, 3'-PHOSPHOESTERASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13298">
        <property type="entry name" value="LigD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA ligase D 3'-phosphoesterase" evidence="2">
        <location>
            <begin position="98"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF75191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="435" mass="48310" checksum="B6E92FE0CE1D595C" modified="2005-04-26" version="1">MNDALDANRRLSTLDRPISPPLTRPLTRTGNDSLSALEAGKEEVDDPLERISAHLHKFTPDRAATPPVAGGSCLIPFDAWKSLYTRNCHASGNHFVIHQHDHPIAGPHYDLRLQFSASSSVSWSVMYGLPGDPNSRRLNRNATETRVHALWNHLIETASEKTGSMIIWDTGVYEVLPDRTKVSNTGPETDDSDQDPEMHSGSGLDSSALPENEKLRNAFQNSKIHLRLHGTRLPKNYTIFLRRDKTDFRSAPTAASLLQKPRKRRRRRVAKAEPRSTSSSESDRETAGPADTQSPGSGKRGRQTDTGTEGEHEHSDAEGGDTDVDFQIRLNNAYPGAVNDIGSIHQRRWFIMLDRAGSGFVPEKASHSKTDLLGKKRWIRGIDKQTGARTGFDPFYVRGPEVERSVVTGRRGPDVVRDEGVQGFVPRKGWTPVLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B6T6</accession>
    <accession>C8V7A5</accession>
    <name>Q5B6T6_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small ribosomal subunit protein mS29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ANIA_03744</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mS29 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF75486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_661348.1">
        <property type="nucleotide sequence ID" value="XM_656256.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B6T6"/>
    <dbReference type="FunCoup" id="Q5B6T6">
        <property type="interactions" value="79"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5B6T6"/>
    <dbReference type="GeneID" id="2873168"/>
    <dbReference type="KEGG" id="ani:ANIA_03744"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN3744"/>
    <dbReference type="eggNOG" id="KOG3928">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046315_1_0_1"/>
    <dbReference type="InParanoid" id="Q5B6T6"/>
    <dbReference type="OMA" id="GLAHWMT"/>
    <dbReference type="OrthoDB" id="274828at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019368">
        <property type="entry name" value="Ribosomal_mS29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12810">
        <property type="entry name" value="MITOCHONDRIAL 28S RIBOSOMAL PROTEIN S29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12810:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10236">
        <property type="entry name" value="DAP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBF75486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="499" mass="54305" checksum="B2A3C68A2EB9D067" modified="2005-04-26" version="1">MASSFCSGCLTRLRQGPRAVLPPTTAVSRAAFHTSTALHRAVQKPKVSGHEGPKYRVGAAVKIKKKKPMEKSRPPAVGERKALRKRIILSNPNALEVEGMQELNGETMVDSRLRGQVLALPVPMIDQLRAVQAFKTSQGWSIFRRPGTVLRRETLEMGRLFDNISGEAAGSRTVVKKIITGQRKTGKSVHLLQAMAMGFTKEWVVITVPEARDLVTGTTSYAPLSEEEPNAYVQNAVTAALLSRTVTANQKVLSALHISQHHPALSAVKPGMTLEDLAKLGIQDQANAWPVFKALWAELTATSAVPGLEKNFRPRPPTLVTVDGLDHWMQNSAYRNAKHEPIHAHDFVFVRHFLNLLMPGKGKSTLPNGGALLYATSSSNSPSIYAFDVALKQVAARHAGVDPSSSEFPTPRPYSNPDPRVLEAFNSPKPTAAKEGMLDVQELGGLTKDEARGYLEYFARSGLLRETVSNESASEKWTLAGGGVIGELEKLGRRLRVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B706</accession>
    <accession>C8V3T2</accession>
    <name>Q5B706_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical PH domain protein (Eurofung)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_03674</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
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    <reference evidence="5" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
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                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
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    <reference evidence="5" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
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                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
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                <person name="Cornell M.J."/>
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            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
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        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051283">
        <property type="entry name" value="Sec_Metabolite_Acyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054710">
        <property type="entry name" value="Tri101-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31896">
        <property type="entry name" value="FAMILY REGULATORY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G14730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31896:SF64">
        <property type="entry name" value="TRICHOTHECENE 3-O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22664">
        <property type="entry name" value="TRI-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Trichothecene 3-O-acetyltransferase-like N-terminal" evidence="3">
        <location>
            <begin position="16"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBF82815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="465" mass="51150" checksum="2DD70A23A28F621D" modified="2005-04-26" version="1">MSFQDLLGQLPLLKSYTHILLVFPLVNSQRQPVLEALQCSIRRLLATFPFLSGAVVHQVPHPGHSGTFSVVLPEGDSSDRVQQILHVKDLSSILPDYATLNAAKAPPAMLPGPLVAPSRPAFPRVYEESSAPVLEIQASLINDGLLLTLAAQHNIVDATGIFYIAHLLSRFMYDPTASIPDAEVAMGNIDRRNLIPLLPENQVLPEEMGIFTMDRPPPLTREILDEYKWTLVHFSPAAVREMHDEAMSQPNDFIDGVSSVSVNDALTAFCWRRLSIIRAEHSHTRGEGATTQLTRAADLRRAMGLNPGYAYMGHMVRTSNLRLPLSTLVCPRTSLSHISSLLRKCLREHTEPQAISAYATLLFRTEDKSRILYAAEFNPLTDLSVSSVAHVDVPSFGTVLGKPRFVRRPTFGPLPGGMYLGPSMGSEGEEASGDGGLDAVICLRGWEVEGLAKDPEWKKKVVVWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="143" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B801</accession>
    <accession>C8VHW4</accession>
    <name>Q5B801_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">ABC multidrug transporter (Eurofung)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">ANIA_03329</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF82934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_660933.1">
        <property type="nucleotide sequence ID" value="XM_655841.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q5B801"/>
    <dbReference type="GeneID" id="2874222"/>
    <dbReference type="KEGG" id="ani:ANIA_03329"/>
    <dbReference type="eggNOG" id="KOG0065">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_35_0_1"/>
    <dbReference type="InParanoid" id="Q5B801"/>
    <dbReference type="OMA" id="QKNFAFF"/>
    <dbReference type="OrthoDB" id="245989at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03233">
        <property type="entry name" value="ABCG_PDR_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03232">
        <property type="entry name" value="ABCG_PDR_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001465">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000054">
        <property type="entry name" value="ABC multidrug transporter atrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034001">
        <property type="entry name" value="ABCG_PDR_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034003">
        <property type="entry name" value="ABCG_PDR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010929">
        <property type="entry name" value="PDR_CDR_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06422">
        <property type="entry name" value="PDR_CDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="510"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="543"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="645"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1079"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1103"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1145"/>
            <end position="1171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1186"/>
            <end position="1203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1215"/>
            <end position="1236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1343"/>
            <end position="1360"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="42"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="736"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="698"/>
            <end position="730"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CBF82934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="1361" mass="151713" checksum="4DB53652581E1895" modified="2005-04-26" version="1">MVEQQTDKDKRLGITWYNLIVKGIATDAAFHDNVGSQFNIPARVKGSRAKPLLRTIIDNSHGCVKPGEMLLVLGRPGAGCTSLLKILANRRLGYAQVTGEVRYGSMTADEAKPYRGQIVMNTEEELFFPTLTVQQTIDFATRMKVPHHLHSNSTKARFQQFNRDFLLRSMGIEHTRDTKVGNEFVRGISGGERKRVSIIETMATRGSVFCWDNSTRGLDASTAMEYIRCMRAMTEVLGLSSIVTLYQAGNGIYDLFDKVLILDEGKQTFYGPLHQAKPFMEELGFLYSDGANIADYLTSVTVPTERRVKPDMESRYPRNAEELRSYYEATQLKRKMALEYNYPISAEAAEATKNFQEAVHSEKSPALSRRSPLTVSFSTQVKSAVIRQYQLLWGDKVTFLIPQGLNFVQALITGSLFYNAPKNSSGLPFKSGSLFFAILLNSLLSMSEVTNSFAARPVLAKHRGFALNHPAAFCFAQIAADVPLILTQVTLFALPVYWMTGLKATGEAFMIYWITTISVTMCMTALFRAIGAAFSSFDAASKVSGFLMSALIMYTGFLLPKPSMHPWFSWIFWINPLAYGYEAILSNEFHGQLIPCVNNNLVPNGPGYTNSEFQACTGIRGVPAGASVITGDQYLQGLSYSHAHVWRNFGIMWAWWVLFVILTVYFTSNWSQVSGNSGYLVIPREKAKKTKHLTMDEEAQPGLDLHDSSHRGGTSPIDDEKGSHTNSSSKVDAQLIRNTSIFTWKGLSYTVKTPSGDRVLLDNVQGWVKPGMLGALMGSSGAGKTTLLDVLAQRKTEGTIRGSILVDGRDLPVSFQRSAGYCEQLDVHEPLSTVREALEFSALLRQSRDTPVVQKLKYVDTIIDLLEMHDIENTLIGTTAAGLSVEQRKRLTIGVELVSKPSILIFLDEPSSGLDGQAAFNIVRFLRKLADVGQAVLVTIHQPSASLFAQFDTLLLLAKGGKTVYFGDIGHNGATVKEYFGRNGAPCPQNTNPAEHMIDVVSGSLSVGKDWNEVWLTSPEYTAMTQELDRIIMEAASKPPGTLDDGHEFATPIWTQLKLVTNRNNASLWRNTDYINNKFMLHVISGLLNGFSFWKLGNSVADLQMRLFTIFNFIFVAPGVMAQLQPLFLERRDIYEAREKKSKMYHWSAFATGLVVSELPYLVLCAVLYYVTWYYTVGFPSGSDKAGAVFFVMLMYEFIYTGIGQAIAVYAPNAVFAILVNPLVIGILVFFCGVYVPYSQIHEVWRYWLYYLNPFNYLMGSMLVFTTFDAPVHCERSELAVFNTPDGQTCGEYLADYMQGLGSRTNLLNPNDTQDCKVCQYRTGSDYLYTINLKDYFYGWRDAAIVALFAVSSYACVYALM</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B820</accession>
    <accession>C8VHZ1</accession>
    <name>Q5B820_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Extracellular conserved serine-rich protein (AFU_orthologue AFUA_3G00880)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ANIA_03310</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF82983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_660914.1">
        <property type="nucleotide sequence ID" value="XM_655822.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B820"/>
    <dbReference type="GeneID" id="2874355"/>
    <dbReference type="KEGG" id="ani:ANIA_03310"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN3310"/>
    <dbReference type="eggNOG" id="ENOG502S7YR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_088618_1_0_1"/>
    <dbReference type="InParanoid" id="Q5B820"/>
    <dbReference type="OMA" id="SFDIYLV"/>
    <dbReference type="OrthoDB" id="5316007at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052479">
        <property type="entry name" value="GPI-anchor_Adhesion_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018466">
        <property type="entry name" value="Kre9/Knh1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35185">
        <property type="entry name" value="SERINE/THREONINE-RICH PROTEIN ADG2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35185:SF1">
        <property type="entry name" value="UPF0619 GPI-ANCHORED MEMBRANE PROTEIN C1322.10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10342">
        <property type="entry name" value="Kre9_KNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010273969" evidence="3">
        <location>
            <begin position="19"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal" evidence="4">
        <location>
            <begin position="24"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="116"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="116"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBF82983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="220" mass="21888" checksum="108283244685F76D" modified="2005-04-26" version="1">MRLVLASSLLPLAVSVGALQVTEPEKGAEIDPSSSFTVKWDSVSTDPSSFDLYLVNNAVYPSVEKKIASDVDTSEGSYTVDGVSGLENGGGYQINLFSNSGHNTGILAQSEQFNVTGADSTSSSTSSTTTPTSTSSKSTGTESTTSTSTGTSTTLSSTTPTTESESASVTPSSSGSSTPSSSNATASATGTPDDPNGGVTIGTPLAVLAGLVGGAVLFTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="116" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B956</accession>
    <accession>C8VJ58</accession>
    <name>Q5B956_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NRPS-like enzyme, putative (JCVI)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ANIA_02924</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF83739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_660528.1">
        <property type="nucleotide sequence ID" value="XM_655436.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B956"/>
    <dbReference type="STRING" id="227321.Q5B956"/>
    <dbReference type="GeneID" id="2874154"/>
    <dbReference type="KEGG" id="ani:ANIA_02924"/>
    <dbReference type="eggNOG" id="KOG1178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002220_0_0_1"/>
    <dbReference type="InParanoid" id="Q5B956"/>
    <dbReference type="OMA" id="DAPINGY"/>
    <dbReference type="OrthoDB" id="429813at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031956">
        <property type="term" value="F:medium-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051414">
        <property type="entry name" value="Adenylate-forming_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
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    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439:SF2">
        <property type="entry name" value="ENZYME, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439">
        <property type="entry name" value="PHENYLACETATE-COENZYME A LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23562">
        <property type="entry name" value="AMP-binding_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="22"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="Thioester reductase (TE)" evidence="4">
        <location>
            <begin position="661"/>
            <end position="834"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBF83739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="984" mass="108422" checksum="1A1EB973F913F216" modified="2005-04-26" version="1">MSRLKESKQAGRRLLLNYIDAVAAVNPTKVVFTQIISFDPPVQYDLTYQELASIVNRQAWWLAECLHGKARDVTIAYVGPSDARHLILSLAAVRAGSRLLLLSPRNSVAIHEHLIKETQSAAILYDSSFSTAITELTSLSQITAVQAPGLVDLLSDTTLANEYPYGDTFKDASDKPLVVFHTSGSTGMPKPVTFVHSALAAVDSLRELYSEDSYRVSVHRVIDAVEATYNGCPLFHTAGFVVSFFLVFSGCVTVIGPPDQPSSPQMFKQILHSTHTQGALLPPLVIDQIAEEPAMVEEAAKLKFLTYGGGSVSRAAGDLLSKRTNLINVLGSSECGLIGAYMTEPEHWDWFHFAEKEMGIKWEPVDEAKEKPEFFEMVLRREELPQKQAVFANFPDLDEWHMRDIFYRHPTIPYYYKYQSRKDDVIVFSTGEKTNPIDVEAGINSLPGVAASLVVGHKRPYPVLLVELAASATVDDTLPDIHRVLEELNKLSMKYAQIHRGDVLFAEPEKPFVRTPKGTINRSQTNKLYAEEIEALYSSATEIPDQALQARLDPSTDETLTESIAAMVGDLTEVKDLGISDDFFASGLDSRQVQILAATLARSLPDQKDVLFLRNAVYMNPTASGLVNYIRRNATEDVSATLDALFEKYEAIRALAYPVTNEPLLGLHEEAYTHLVSTVTEVIHCQWPVTFNLPLALFEPQFAGIVNLVQLAYDSQQNARIIFLSSIATIQGWDKGTPVPEAPLDLIKYTQGGYGQSKMLASKLLGQAVATSGVHSAVCRVGQVGGPIHGDGKWPERDWFPTLLRASEVMGVLPNSIGHFDDVDWLPVDSLSAALVTLALDLDDLDTEQTGPKTNKGAAYYHFTNPSVSSYPELIPAITRHLANGTSTMKLELVDTLAEWTERLAAWTPTSNGTDSGESKAVESYMTAATALLEFYQGLASNLDQPNVMLDTTLTTGKIPYLTTVGAVNESWIELWLDQWGFRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B9H7</accession>
    <accession>C8VJJ4</accession>
    <name>Q5B9H7_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ANIA_02803</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF83982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_660407.1">
        <property type="nucleotide sequence ID" value="XM_655315.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B9H7"/>
    <dbReference type="GeneID" id="2874432"/>
    <dbReference type="KEGG" id="ani:ANIA_02803"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN2803"/>
    <dbReference type="HOGENOM" id="CLU_1981584_0_0_1"/>
    <dbReference type="InParanoid" id="Q5B9H7"/>
    <dbReference type="OrthoDB" id="4469944at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35605">
        <property type="entry name" value="ECP2 EFFECTOR PROTEIN DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35605:SF1">
        <property type="entry name" value="ECP2 EFFECTOR PROTEIN DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF83982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="126" mass="13953" checksum="65CAAF6AA62A2CC2" modified="2005-04-26" version="1">MACGAIHCAGKAIAAPADGFRHGLDQLRYIEMNGGISGPGGSLEPSMGLEPNTCGEVYCFYSTSIRWCNEDKKHYKTMLYQHIREGAQDVYHKCLTKYKGKDVSGGVIDHNDNWSVIVQEDARCKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B9M3</accession>
    <accession>C8VJW7</accession>
    <name>Q5B9M3_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">SMP-LTD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">ANIA_02757</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF84078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_655269.1"/>
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        <property type="interactions" value="25"/>
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    <dbReference type="STRING" id="227321.Q5B9M3"/>
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    <dbReference type="KEGG" id="ani:ANIA_02757"/>
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    <dbReference type="eggNOG" id="KOG2238">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="InParanoid" id="Q5B9M3"/>
    <dbReference type="OMA" id="AKKWSWS"/>
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        <property type="component" value="Chromosome VI"/>
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        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0000318"/>
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        <property type="entry name" value="SMP_TEX2"/>
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        <property type="entry name" value="SMP_LBD"/>
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        <property type="entry name" value="NUCLEUS-VACUOLE JUNCTION PROTEIN 2"/>
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    </dbReference>
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    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
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    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
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            <begin position="7"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="SMP-LTD" evidence="11">
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            <begin position="276"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
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            <begin position="40"/>
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="480"/>
            <end position="572"/>
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    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="596"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="738"/>
            <end position="824"/>
        </location>
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            <begin position="844"/>
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            <begin position="43"/>
            <end position="57"/>
        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="620"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="9">
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            <begin position="647"/>
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            <begin position="683"/>
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            <begin position="865"/>
            <end position="913"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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            <dbReference type="ARBA" id="ARBA00023055"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CBF84078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="927" mass="102187" checksum="99350958C7EDEF92" modified="2005-04-26" version="1">MGLFNSFLFVYLLGGFTFLPLVLSLFLLYSYLVLPPSSPQSERVSDSADTSIHRPNDDQFSLKSGTDELAEEFYRTHDTDVAAGYFVVCREYVPGGINGKPPERTTPAGEVVGPESPSVYQTMYRSLFDRKQSPTIEPAKNMARNGKRTRNMFYIVLRHGHLMLYDDADQVEVRYVISLAHHDVSIYGGEGEIPEGELWLKRNAISLSRRLDSLGDLGGPTPPFFFFSENLSDKEDFYFAMLQNQSKMVHFPKGPPKHQDIDVKHIVTLVQRLHSSEEQLQTRWINAVLGRMFLALYRTPEVEEFVRTKIVKKISRVNKPNFISKIGLRSIDMGNGAPFIINPRLKDLTVDGNCCVETDVQYTGSFRVEITATVRIDLGQRFKAREVDIVLAVVLKKLEGHMLIRLKPPPSNRAWISFESMPNMDMDIEPIVSSKQITYGIILRTIESKIREMVAESIVLPFWDDVPFLDTMAQRFRGGIWQRDSSEPGSTVEIPDESGSRPQVPESSGTVKASKPADDRTMSAPALSESATNTATRRKKSEASEMLDKGSSTALSSPVGKNPNSPPRAIRSRTFSHTADPVLTADHGQVDAILSDFKTDEKGNATSSMIEISRRSPLVTPSKTPGSSPPSDHQSLSDIVHPGCESFNASSVGNLGETSSDPFKSPSSTQAVHSALDMRDAASQSSSSLNSNKTRRSSTLDSSAVSSASHISSDKKFQSSLSLGAATSIAKKWGLNMFGSKESHTNSGVGLSRPAGTPEEPIGRGHPFPPPGIPLPTPAKVNNKRNSVSVPKRKPVPSTSLQEEMTLDGNGRNQLPSKFPPSRRKTVLDFDVDAARSDELLVVEPPYDSTPNSPADFTPASGLPDQRRFATKEPRDLAQVDTKVETRQNHAEEHSTMDRLSALDRSENKERNPTKPPATDNCLLEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="110" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BA02</accession>
    <accession>C8VHH9</accession>
    <name>Q5BA02_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Tc1-like transposase DDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_02628</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF84331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_660232.1">
        <property type="nucleotide sequence ID" value="XM_655140.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BA02"/>
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    <dbReference type="KEGG" id="ani:ANIA_02628"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN2628"/>
    <dbReference type="eggNOG" id="ENOG502SJME">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038496_0_0_1"/>
    <dbReference type="InParanoid" id="Q5BA02"/>
    <dbReference type="OMA" id="ANTEWED"/>
    <dbReference type="OrthoDB" id="4502264at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tc1-like transposase DDE" evidence="2">
        <location>
            <begin position="197"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="297"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF84331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="331" mass="38468" checksum="0849618B83CD6AEE" modified="2005-04-26" version="1">MPAPHPNELRVQVLSYWALGIQPPDIAKMLQINVRTIWDMIQKGQDRGYNPAQSMRVKLEYVEDGKRSGRPKEISEATDMAVLASVKQDRNGREKSSEILAFEAETAYQHKKSEVEIAALNAELEPILREEWEIETRLKRLHLRGVPGRVPTWRFTEKTGKLVRKSKGGVDWWRYQQEILLPHLIPFAKACKIERPDTKVLEDGAPAHKHHAQRRIYSIHEIEKIFDWPGNSPDLNAIEPCWMWMKKRTTSRGAPRDKKTGKTAWIKAWNELPQEKIQGWIERLIRHIQEVIQHDGGNEYKEGRTDHDARSWKGRRIKGQLSARQDLSPDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BA80</accession>
    <accession>C8VPT4</accession>
    <name>Q5BA80_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ANIA_02550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF87078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_660154.1">
        <property type="nucleotide sequence ID" value="XM_655062.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BA80"/>
    <dbReference type="GeneID" id="2875577"/>
    <dbReference type="KEGG" id="ani:ANIA_02550"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN2550"/>
    <dbReference type="HOGENOM" id="CLU_1786821_0_0_1"/>
    <dbReference type="InParanoid" id="Q5BA80"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF87078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="145" mass="16279" checksum="16BDF2F624142422" modified="2005-04-26" version="1">MATGMSPIIRNKMIASIHSTHTYLKPPKHPQLHDIGHAAVSDISGEIILPIVLLVPDDGVSLAISVKSQLLQRLPERLLQGNIDDRPPNLRAIFAVSSSRLCWHYFHAAVLEGRGLAAKQNRPRHYKDVEHVLMTMDVQSENEYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="110" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BAT2</accession>
    <accession>C8VNF1</accession>
    <name>Q5BAT2_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ANIA_02348</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF86661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_659952.1">
        <property type="nucleotide sequence ID" value="XM_654860.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BAT2"/>
    <dbReference type="GeneID" id="2874934"/>
    <dbReference type="KEGG" id="ani:ANIA_02348"/>
    <dbReference type="eggNOG" id="KOG4177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_309495_0_0_1"/>
    <dbReference type="InParanoid" id="Q5BAT2"/>
    <dbReference type="OMA" id="RIRICQA"/>
    <dbReference type="OrthoDB" id="366390at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="F-box" evidence="4">
        <location>
            <begin position="9"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="64"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="96"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="355"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="388"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="458"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="490"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBF86661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="952" mass="104719" checksum="76A2FA20CE023677" modified="2005-04-26" version="1">MASSHPQTTQFLHQLPAEIILSIADALSVRDLNRLLRSCRRFASLLRPRLYRLATTYTFEAHGRRKSPLTWAAEHGILSTVQEMLDAGADVTATVGGFTAFYQALRNGHTEVVRVLLDAGADPLPSKSNGGIPLVLAAQHGDEELLRLLLRVTPTNATGERANYEHAVARAIYHGHIRLVRFMLDNAAGWLDVAHNGHLIYQAASTGNCDMIRLLIGYGATVEPLHRTARHPLVVAAQNGHKEAVQLLMTLSKEKSAPTAEPVKDPEERSISARLVDRFGTDVSQPTKDGLTPLQITLEEFSPPEVIHQLLDLGAEPSVQSRDGSTALHTLVRLKRYDLLETLIDGASLSASDSKGRTPLLLAVAVFNVSAASLFIECGADLAARDIHGRTVLHLAASHSSGVILSMLLRAGADVSATDEAGRIPLHYTTFGSNLTIPSAFIATHRATRTDHLVRSHTGRTVLDMAAESGNLDLVRELIREGADVNSHWEGYSPLHAAVANRHPELAELLLSHGANPLRLDYYGQTPFDLAAGDRSMLDGLARWCDIPYTRTDRDTRRGVLKESVLRFASRISDGQTGDFYKLAKCLVYLKDDEAALAAFRQAARIRACEDDLRYPMCCGGCRKRLNAPRFSEAVVLVCRRCHELDFSDPSPFLGFYSTDAGFATPSNSDERGNDELWNEQLEQIIRPRYVAKPMSKQRVTRIFGYIAIPSIVTGLGIHSGLKHLENKYPELPPAAAGSKALSTPARPTQHCPYTDIYAARIPLRALQARTRHPETKDQTALEEAWARSLLSCRLLRTEASLIGLLTRGKYEPGDLGDNGFGPGPGSEPRVLLNGALTVQRQPGAEGSNSLLVSWKMPDGPRLFFEKIARWGYPWRLMSGGRHEMIVSEPFNVKGQGEMVEVRFSAAHDYEIVEEEGGLQQQKVLPAWAIRLHRGYARLILDMAARDVERGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BAW2</accession>
    <accession>C8VN67</accession>
    <name>Q5BAW2_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SH3 domain protein (AFU_orthologue AFUA_5G10580)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_02318</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
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        <property type="protein sequence ID" value="CBF86597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="entry name" value="SH3 Domains"/>
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    </feature>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CBF86597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="522" mass="55301" checksum="4B7DA2028F28BF32" modified="2005-04-26" version="1">MSGTCISLSGSTQCPAFNASSISTNSNLYTDFPFLRNVTNLSEFDAALNSYVLGSYIQSKYSVFLGCQGDLSNASDYYARYTTSAICSGLVQSSESDCDLSAEQSRPLCAEDCALMASSEEEIVVNDELCPDRRSDYLNQIRSDFAVCTGPDGSLTGSCISAADNEPNECGFRSNLIGLCGFCASSTVNSTDSCCVNANASSRCEGVDLPTPTTSFIPIYTTGTDAGNDTDNGLSGGQIAGIVIGSVAGFAILAVLIAFGLIYYWRRKREATDDNSLNKPNPQRKGSPMQQPGNQAFGVAPGRVARMSALREAPSSSPGHSRSSGAFLGGSAKYSDSSDSEGFASPGAINKKIPPTTGKRQGSLSSNSALAGVGSDTSPRSGTIGQYSSPEGLTSGQSEQLSSFQDYYSQDDIHPGDKVAVLWAYQPRAGDEFGLERGEMIKVIGIWDDGWATGVRVPESAEEYDARHREQRDSGVSGRSQRTSPAPSGEIKAFPLVCVCLPQHWRKIIDGAQGDDEVAERY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BB06</accession>
    <accession>C8VMX2</accession>
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            <taxon>Eurotiomycetidae</taxon>
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            <taxon>Aspergillaceae</taxon>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
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            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="GeneID" id="2874767"/>
    <dbReference type="KEGG" id="ani:ANIA_02274"/>
    <dbReference type="eggNOG" id="ENOG502QSZU">
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    <dbReference type="HOGENOM" id="CLU_023536_1_0_1"/>
    <dbReference type="InParanoid" id="Q5BB06"/>
    <dbReference type="OMA" id="HYGPQDI"/>
    <dbReference type="OrthoDB" id="349045at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
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    <dbReference type="PANTHER" id="PTHR42107:SF1">
        <property type="entry name" value="WHIM1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42107">
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        <source>
            <dbReference type="EMBL" id="CBF86513.1"/>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="564" mass="62247" checksum="5FF1F47D0F1F150C" modified="2005-04-26" version="1">MSKMSLSDSELSSLSSAPPSDEESTPMALDEPVGITKYFQKKQQSESPPPKRAPSPPHEYVLADNPDIAFIVMFRARFHEVFPRSTPHFGPQDIERGVSESPPGDHIERLLCALLGLVLNRKKDVERNHYTRPLEEAVQTHASQWPKAWGGKNPLHGGRSFALMSPEERSLILWSLSSSDAVQAKIKESYKQARHEDDLNQPLSVQPWGRDSLKRRYWLIEGLDDTHFRLYRESNPALKHVTWWSVAGTIPELLSVAQKLEEEKGTNSKKLSERIRNSIPRFEGSEEKRKRRDYRIARKAAFSRPEPGFSLYEGRTRGKKLKYTYSDDEDIFSDGLPPPRRSGRNTSGPSTPAEPTGPRFTASGRQVRSRAGGLYGESLLAGQREDTDLAEDGGSERRQRTRITRTNGYTDYGMDDDEDTNSNDAQSSGNEWQGGEEEDENDFEGDDEEDVSGDESVINGKPPSLVVQLRYGKQGDDNNTGEQKVQTTSDSQKAATTGLQQPAPVDNAPQDSIPETPASLDTKNAPAETPATSAPLASSGGATQGLGGPVGTTMPSVQQPDGTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="117" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BBG0</accession>
    <accession>C8VM01</accession>
    <name>Q5BBG0_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Importin subunit beta-4, putative (JCVI)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ANIA_02120</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF86216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_659724.1">
        <property type="nucleotide sequence ID" value="XM_654632.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BBG0"/>
    <dbReference type="FunCoup" id="Q5BBG0">
        <property type="interactions" value="1232"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5BBG0"/>
    <dbReference type="GeneID" id="2875634"/>
    <dbReference type="KEGG" id="ani:ANIA_02120"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN2120"/>
    <dbReference type="eggNOG" id="KOG2171">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003794_1_1_1"/>
    <dbReference type="InParanoid" id="Q5BBG0"/>
    <dbReference type="OMA" id="ANACGCV"/>
    <dbReference type="OrthoDB" id="7862313at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061608">
        <property type="term" value="F:nuclear import signal receptor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008139">
        <property type="term" value="F:nuclear localization sequence binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058584">
        <property type="entry name" value="IMB1_TNPO1-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040122">
        <property type="entry name" value="Importin_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057672">
        <property type="entry name" value="TPR_IPO4/5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10527">
        <property type="entry name" value="IMPORTIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13513">
        <property type="entry name" value="HEAT_EZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25574">
        <property type="entry name" value="TPR_IMB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25780">
        <property type="entry name" value="TPR_IPO5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="9">
        <location>
            <begin position="24"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="8">
        <location>
            <begin position="386"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="8">
        <location>
            <begin position="480"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBF86216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="1093" mass="121457" checksum="C1677B39978541C0" modified="2005-04-26" version="1">MDQQRFLQQLQVVLNPTQGNVKEATGILQREYYKHPEALVLLIQVATGHDDAQLRQLAAVEARSLVGKHWAKVQAGQKPALREQLLRSGVSEANDLVRHSVARVISAVAKVDLEDGEWADLPNFLMRAADGGNKDERAVSLYILFTILETLGEGFEEKFQDLFTLFGKTIRDPESADVRINTLLALSKLAMYLDSAENMGPVKAFQDLVPSMVAVLKDAIDQGEDDRIMQAFEVFQTLLGFDPALLTVHLKDLVLFMNEIAANTEIDEDTRTQAISFLMQTVQYRKLKIQGMRLGEQLARTAVQIVTELGDAAPNDDDITPARSALGLLDMLAQSLPPSQVVVPLLNTLGQYFNNANPDYRRAGIMSLGMIVEGAPDFISTQMKEIMPIVLQLLADGELKVRQATLHAVARLADDLTEDLNRDHEKLMPLLFQNLASAMQESKGEEEGPTVDIMKAGLSAIDAVVDGLDEKDVAPYQNELVPILHQLFKHPNYRIKGLAAGALGSLASSAGEAFLPFFDDSMHLLQEFATVKDSEEQLDLRASVTDAMGEMSAAAGPERYQAYVEPLMRATEEALHLGHSRLKESTYIFWGAMAKVYGEHFATFLDGAVKGLFNCLEQDDDDLELSLGEAAKDLIGQEVTVAGRKVKVASAEDDDDEPVGEDGEIEDVDLDDEDDWDDITATTPLALEKEIAIEIIGDLVTHTRSAYLPYFEKTIEMVMPLVEHPYEGVRKATISTMHRSYAMLFTIAEESGQMPKWKPGLPLQVEPAKEVKKFGEILMTATIKMWTEEDDRSTVADINRNMAENLRFCGPALIANETTLHNVIQMITDIITKKHPCQLEFAEEDVDAGEETSEFDWIVVDTALDVVSGMAAALGESFAELWKVFEKIVLRYAGSTESIERATAVGVLAECINGMGAASTQFTPAFLKLLVHRLSDEDPQTKSNAAYAVGRLIEHSNSPEVVKEFPTILSRLEQCLHQDVSRLQDNATGCLSRMILKHRESVPIKDVLPVLVNILPLKNDYEENDPLYRMICQMYKWEDPTIRELTPQFLPVFQSVLCGDTDQLEDERRAELIELVKWLNQMQPGAAPWAEQL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-11-22" modified="2025-06-18" version="103" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BC23</accession>
    <accession>C8VKS7</accession>
    <name>SWF1_EMENI</name>
    <protein>
        <recommendedName>
            <fullName>Palmitoyltransferase swf1</fullName>
            <ecNumber>2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">swf1</name>
        <name type="ORF">AN1907</name>
    </gene>
    <organism>
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Palmitoyltransferase that targets several endosomal SNAREs. Palmitoylates the SNAREs at cysteine residues close to the cytoplasmic end of their transmembrane domain. May have a role in the cellular quality control of transmembrane domain-containing proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DHHC palmitoyltransferase family. SWF1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225"/>
    <dbReference type="EMBL" id="AACD01000029">
        <property type="protein sequence ID" value="EAA65072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF85801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_659511.1">
        <property type="nucleotide sequence ID" value="XM_654419.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BC23"/>
    <dbReference type="FunCoup" id="Q5BC23">
        <property type="interactions" value="27"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5BC23"/>
    <dbReference type="EnsemblFungi" id="CBF85801">
        <property type="protein sequence ID" value="CBF85801"/>
        <property type="gene ID" value="ANIA_01907"/>
    </dbReference>
    <dbReference type="KEGG" id="ani:ANIA_01907"/>
    <dbReference type="eggNOG" id="KOG1312">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042181_2_1_1"/>
    <dbReference type="InParanoid" id="Q5BC23"/>
    <dbReference type="OMA" id="HIYLIWA"/>
    <dbReference type="OrthoDB" id="9909019at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883:SF480">
        <property type="entry name" value="PALMITOYLTRANSFERASE SWF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883">
        <property type="entry name" value="ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0012">Acyltransferase</keyword>
    <keyword id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword id="KW-0449">Lipoprotein</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0564">Palmitate</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000212989" description="Palmitoyltransferase swf1">
        <location>
            <begin position="1"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="2"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="3"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="2">
        <location>
            <begin position="24"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="2">
        <location>
            <begin position="100"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="2">
        <location>
            <begin position="129"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="2">
        <location>
            <begin position="220"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="266"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="2">
        <location>
            <begin position="287"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="DHHC" evidence="3">
        <location>
            <begin position="155"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="412" mass="47344" checksum="2632DBE29AC15B23" modified="2005-04-26" version="1">MGLLRTIALVILGFSAFIFTVLFGRLPVFRKTPIGLLHRIIWLHIPHGISYIDARLFNGRILRSWGQAGNYILYENHPLVLIFFTTILVIGELIFIPSAWPRISVMHQLYIPIIIALPYYFLYVSVVTKSYITPDNHAEEMKRYPYDKVIFHPGHSCETCHFLKPARSKHCSYCKRCVSRQDHHCIWLTNCVGLNNYHYFLYLLLSLSVMLTYGSWLGYSLLSQTLDRLIPPSSPVRLRKQSWPTFLNMWAAVVAYDTRIGGVTMLMFMTAPLAFAFLVYHVYLIWAGMTTNESAKWSDWKDDITDGMAFKFIGDHKRSDSPLLESAETADSWPGYSDQILVLTEGDPPKEGHQVHKSSNDVIQPTNPDAPIDRRFARVRSMKEIDNIYDLGFWNNLCHVFGNYAAGKAHRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BCS9</accession>
    <accession>C8VNJ7</accession>
    <name>Q5BCS9_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ANIA_01651</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the paxB family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF85295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_659255.1">
        <property type="nucleotide sequence ID" value="XM_654163.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BCS9"/>
    <dbReference type="GeneID" id="2875318"/>
    <dbReference type="KEGG" id="ani:ANIA_01651"/>
    <dbReference type="eggNOG" id="ENOG502SNJ3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087059_0_1_1"/>
    <dbReference type="InParanoid" id="Q5BCS9"/>
    <dbReference type="OMA" id="IGWICLY"/>
    <dbReference type="OrthoDB" id="5294024at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039020">
        <property type="entry name" value="PaxB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42038">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42038:SF4">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25129">
        <property type="entry name" value="Pyr4-TMTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="27"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBF85295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="225" mass="26417" checksum="283FBA7977232645" modified="2005-04-26" version="1">MSDFWLTDHIRHLVVQPADARLNPPEAYLFVQDGLIISCGILYALTYVFCMMRAVKDRVLPGSIKYLSLTLAYELYYAFATTSTRTERICFLVWFQLDLIFVGLALWRVYDHDQWRRVAAEMVVYFVTACGLFRYLGYIYPDDREQVTAYWTGILLQLPVGWTYVYRLLKDRSVLGHSLEIWLVRYLGCFTAYGVFIWRYLNVPQNWEGRVSPINLSLDLSKVNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BCZ0</accession>
    <accession>C8VN83</accession>
    <name>Q5BCZ0_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nephrocystin 3-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ANIA_01590</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF85173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_659194.1">
        <property type="nucleotide sequence ID" value="XM_654102.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BCZ0"/>
    <dbReference type="GeneID" id="2875221"/>
    <dbReference type="KEGG" id="ani:ANIA_01590"/>
    <dbReference type="eggNOG" id="ENOG502SHWH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027356_0_0_1"/>
    <dbReference type="InParanoid" id="Q5BCZ0"/>
    <dbReference type="OMA" id="NNIKALC"/>
    <dbReference type="OrthoDB" id="5419927at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40619">
        <property type="entry name" value="FUNGAL STAND N-TERMINAL GOODBYE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40619:SF3">
        <property type="entry name" value="FUNGAL STAND N-TERMINAL GOODBYE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="4">
        <location>
            <begin position="423"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="336"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBF85173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="626" mass="71160" checksum="78A1F884A231851A" modified="2005-04-26" version="1">MGKEKHHFSRLPWRKSEPATDEDEAWIRKKAGAHHPAFRTPADYDRSEKRYISDEEQAIEYLENLLRKHDDSQPGEPKFYQCSWEVVIQSLTQAQDAYAKNTGCGQRTGMALDVTLSAFEALPAEFGLGTVKGILGLMFRVALQGIENRAKILDAFSSIPNTIVTINVACTVLRPSQGDLDLREEFYRTLIKGMPLLVDVLLRAAPWYRKLKEILLFRIPETVAVDEVLSEWKGIIDSFNQRMQRMRDRMLGTLHQQGVDLQNQADKHFSATENHFRGLREENSTTHDMMRDLQLMMTVIMYNQKQLSKQKAQEASTWHHGLKSGADATTLLYQELQAIRRQGEIQQEENSRLRRENVALREEAALRAETESSWKPTHPSMAALSELELLGVIGVPSNAAWRDLDIVLSQSSSFGSQMLGKAQRLIRTRAFRDWFNQSESSILLVEGYLDISPAASITPISILDATLISSLLDSSNTLVLFAFAGLHREYEKPEVMNGPGGLLRSLIMQLLTSDKFPLSNLEFLTPERIAACQKGDIVALCALFERLLLQVPPSLQVYCILDGLGWYERNPWGQDLLYVISMFEELAQWDFPQTAVIKPMISFPHHSLLVADAVQIPVLWSRRYWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="105" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BDA5</accession>
    <accession>C8VME7</accession>
    <name>Q5BDA5_EMENI</name>
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        <submittedName>
            <fullName evidence="9">Clip 170 homolog (Eurofung)</fullName>
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    <gene>
        <name evidence="9" type="ORF">ANIA_01475</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF84936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_659079.1">
        <property type="nucleotide sequence ID" value="XM_653987.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BDA5"/>
    <dbReference type="STRING" id="227321.Q5BDA5"/>
    <dbReference type="GeneID" id="2875214"/>
    <dbReference type="KEGG" id="ani:ANIA_01475"/>
    <dbReference type="eggNOG" id="KOG4568">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003115_0_0_1"/>
    <dbReference type="InParanoid" id="Q5BDA5"/>
    <dbReference type="OMA" id="KWCAVCE"/>
    <dbReference type="OrthoDB" id="1911237at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CAP Gly-rich-like domain"/>
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    <dbReference type="InterPro" id="IPR032108">
        <property type="entry name" value="CLIP1_ZNF"/>
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    <dbReference type="PANTHER" id="PTHR18916">
        <property type="entry name" value="DYNACTIN 1-RELATED MICROTUBULE-BINDING"/>
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        <property type="entry name" value="TIP ELONGATION PROTEIN 1"/>
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    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
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    <dbReference type="Pfam" id="PF16641">
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        <property type="match status" value="2"/>
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    <dbReference type="SUPFAM" id="SSF74924">
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    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
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            <begin position="27"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
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            <begin position="82"/>
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    <feature type="region of interest" description="Disordered" evidence="7">
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            <end position="378"/>
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    <feature type="region of interest" description="Disordered" evidence="7">
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    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="575"/>
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            <begin position="82"/>
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            <begin position="99"/>
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            <dbReference type="ARBA" id="ARBA00004245"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBF84936.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="668" mass="73480" checksum="253768770ACA19E9" modified="2005-04-26" version="1">MAPLDEIQVGDVVNVPGGMHGTVRFVGVVAGKPGRFAGIELAPEHAKRGKNSGDVDGKKYFATAMPGSGIFVPLNNNKYVTRRTVSNPPTTPSRPVNFSKSVGPGVSVPRPPRMRRPSLPRSESPRVTAPPKLSLSGLRTPSAASKTPTNGFSRSPVKAPSRASDRPPSRFSVEDGPTSARTSDYGRNSMGAEISDLKEQVKALEKQLLDRDQQLEEQANTLSDFQRTLEELEGSDALSIRAQLREKNERIAQLTMEFDMHRADFRSTLDTLEVAASETERVYEQRIDELMQQNKELQDRGEDVEAVARQLKQLEELVSELEEGLEDARRGEAEARAEVEFLRGEVERTKLELKKERESSGLSRESRMSPDGHFSRELEQKDDEIRGLKAIIHSLSRGEPDLHALQQNGFGARPDHNADHVADLEQRVQEYERANEHKTYRIEELERELQQLQANENGRTRSSTVTQSNAQHKPTGSAGKISNGHTINHAHRLSDRTVVPGDWQDEAPQDGLYPAYPSHGRGTSDTSARLETMHESDAQESDTRSEDGGSLWCEICETGGHDILSCTNMFGADAKNNKPAPAPEEQPSHEDSSADEKPSAHSPSSSRSQNAPSQKTGRDVVLEGLRGVGLTSSMAPVAGKASGIIDETKWCALCERDGHESIDCPFDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="101" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BDD2</accession>
    <accession>C8VM63</accession>
    <name>Q5BDD2_EMENI</name>
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        <submittedName>
            <fullName evidence="7">CCCH zinc finger protein (AFU_orthologue AFUA_8G04360)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ANIA_01448</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
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        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CBF84877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_653960.2"/>
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        <property type="component" value="Chromosome VII"/>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:box C/D snoRNP assembly"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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        <property type="entry name" value="NUFIP1-like"/>
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        <property type="entry name" value="NUFIP1_cons_dom"/>
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        <property type="entry name" value="Znf_CCCH"/>
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        <property type="entry name" value="Znf_CCCH_sf"/>
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        <property type="entry name" value="FMR1-INTERACTING PROTEIN NUFIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NUCLEAR FRAGILE X MENTAL RETARDATION PROTEIN INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
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            <begin position="525"/>
            <end position="553"/>
        </location>
    </feature>
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            <begin position="525"/>
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        </location>
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        <location>
            <begin position="630"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBF84877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="653" mass="71193" checksum="DCFA26B128AC097E" modified="2005-04-26" version="1">MNPQGFSFPPPPPPPPTQHPPQQQYAHNNAFTPYGQNHHGQRGGRGGGQFRGRGRGYGNRGRGGHFMSSDANHSGGYAAAHAGYAPMTHSGYPAQHMPNQQTGIPTPHYTQSSSQAFSNAVTGSTFASTSHYPQPAVNGTAYQHQSSYGTTYATPTQQSPPYTQTHPAHQNATPSVQPTMMGPPIRWGFEGTGHSGSFPGLQRPSQRGPRQNNTYNNQSSPGKHANKRDHTSAFGKPQSTAPRFPAPPPVPSFGNPLPLKPPTPVDSQRKPKKKKRKHNQLGLTPKTEEHESSEEEDDADEETRLASGGPGTGVALQITYKGRTSNLQTSADIAAWIAERKKRFPTQAKIEEKKKAMEEAKKAKKAREEAQRQQREARKSAATRAKDQEKKEQTRVALDPADAAAKAKMKAEKLRRKLLKEEKRIAQAEADAERARKMDGVQEDSVPTEREADQPEKKDSAANEQAVGDLASDASDDSDWTSSSGSDLSSSDSDESSDDDDDDSAPEQATSRREGPERVAPPARDEKKRICRHFARNGRCPRGKTCKFAHEKPDRGTKAQPVENKGRKGLLEALLDRQKEDENRKLMETIIWLGENGLLDEPAAQQDVFSTDPTRQTDESTGPLDASDIQLGNVSTSGSVGEQCHPSEGTARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="108" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BDE3</accession>
    <accession>C8VM52</accession>
    <name>Q5BDE3_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">C2H2 finger domain protein, putative (AFU_orthologue AFUA_8G04300)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_01437</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF84857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_659041.1">
        <property type="nucleotide sequence ID" value="XM_653949.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BDE3"/>
    <dbReference type="GeneID" id="2875743"/>
    <dbReference type="KEGG" id="ani:ANIA_01437"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN1437"/>
    <dbReference type="eggNOG" id="ENOG502QVRM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005537_1_1_1"/>
    <dbReference type="InParanoid" id="Q5BDE3"/>
    <dbReference type="OMA" id="HMEQISM"/>
    <dbReference type="OrthoDB" id="5315052at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058925">
        <property type="entry name" value="zf-C2H2_AcuF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35391">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35391:SF3">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04300)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26082">
        <property type="entry name" value="zf-C2H2_AcuF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="864"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="505"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="617"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="746"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="888"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1021"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="524"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="637"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="652"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="888"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="905"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1029"/>
            <end position="1042"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF84857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="1180" mass="131236" checksum="618FF7C31B86CCC2" modified="2005-04-26" version="1">MSAVSPQFVQSDSNDRNLDPELSNPFLTENDPEEAEFQKFTIRLTPVDDRGSAWTGSTSSQDHSINNTSTTGNHEGYGTTYSEFLSPVDEWASDISGHTSPADLMIPGVWPVIATSPQNVTASSPTQSGPSPSSPPASINPSQLLTPVLTNHPSPASDTRSVGSPRIPRAQQPPVPRLKTTLLDDNLGPGPVSESVTTISPIVKVESYSRGDSPVRDSFSTNRRPSQSSIHLSPGGASNASGEDATIEDDRHSVSRSADGAWVPNVLTGQAGLAPDAREDVYVPSPNELDSQRKLAERNADIYTWSEAVSEAHSEAGDDYLCFQRGRTDYHGTRRRAKSTGDPSLDYFSLKFTPDRSEIRGPGLVLHETSDYSDDETESSAPVSVKEERLVQEAFEMTPPEPQSAETGEPQAHQFLGSPPWRDIELDRSPQTTRMQPVSSTQAMVEYQRRARETDAISRVATWGTRDLDANSIRSFQMMSLNENGKEKKHERRNSFLKYLPQKKGNLLKRQRQKTDLSTMQPVHEGEAQDTESKAAPQRKDSFPHRLSLPFTPKTTNYSISGAVMATTRQMAAIGGKDSLSVVSPSTTTTTTTKPWNTLKVRGRSRSEVPRAPGLFELMTTHGGPPVPNISYTSEPVENKEAKHARPQHDAAEEDDDDDSEEKLIMEFPIPKELPIPTLEGFKTQILRLNPRIEPALIDRFAHEQVRRYKRLIEIKQTHARDVNHRKCKAGKFCFALGGTAKLLPPRLSAQDGDSHTQFQIPRPGEEEESSEDLGETTMLAHFPQGVPHPPPQVKLLPAEFECMVCYHVKKFQKPSDWTKHIYEDVQPFTCTFPDCTDPKSFKRKADWVRHESERHRQLEWWECSLADCRHKCYRKDNFVQHLVREHKMPEPKVKKPRNRELSDGASNDPTSLEVQEEINREREINGLWKLVESCHFETARNPREEPCRFCGNVCTNWKKLTVHLAKHMEQLAIPILGLVKERDFPYTVNIGSSGNPDNFSGQVPIAQKDSDFDPRLDTGVTEGPGTADNFTQAPYSNSHPGSSEPIMLPFNTGASYLPNASMPLDSTAPNPAARFEGVTPYTAHGGGVAGLAGDQTRLMAMHQHQNSVTYPPFNARPRLTVPNQDMRVLPEYNSFSMSPTEMQYDPQTTAYVSSGAENHYPYQGPIASAMPYDSGYQGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BEG3</accession>
    <accession>C8VTN9</accession>
    <name>Q5BEG3_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Antibiotic biosynthesis monooxygenase, putative (AFU_orthologue AFUA_1G12025)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_01067</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF88219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_653579.1"/>
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    <dbReference type="AlphaFoldDB" id="Q5BEG3"/>
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    <dbReference type="KEGG" id="ani:ANIA_01067"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN1067"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_131496_9_3_1"/>
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        <property type="component" value="Chromosome VIII"/>
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    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR007138">
        <property type="entry name" value="ABM_dom"/>
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    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
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    <dbReference type="PANTHER" id="PTHR40624">
        <property type="entry name" value="BIOSYNTHESIS MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12025)-RELATED"/>
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    <dbReference type="PANTHER" id="PTHR40624:SF1">
        <property type="entry name" value="BIOSYNTHESIS MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12025)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03992">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABM" evidence="1">
        <location>
            <begin position="6"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF88219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="109" mass="12246" checksum="1D3613850343838C" modified="2005-04-26" version="1">MSSKELYNVVRLVPKPGKFNEVAEAFRTLSKYVEENEPKTQIYFALQPQGTEEFVLVEKYTDSQNLKEHASTAAFKQFSKAIGGWLAQAPEIKRAGFVAGFDGRTKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="114" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BEY5</accession>
    <accession>C8VUS8</accession>
    <name>Q5BEY5_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical oxidoreductase (Eurofung)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_00895</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF88573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_658499.1">
        <property type="nucleotide sequence ID" value="XM_653407.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BEY5"/>
    <dbReference type="GeneID" id="2876673"/>
    <dbReference type="KEGG" id="ani:ANIA_00895"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN0895"/>
    <dbReference type="eggNOG" id="KOG1196">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_29_1_1"/>
    <dbReference type="InParanoid" id="Q5BEY5"/>
    <dbReference type="OMA" id="YPIKNIH"/>
    <dbReference type="OrthoDB" id="809632at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05288">
        <property type="entry name" value="PGDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000121">
        <property type="entry name" value="Prostaglandin reductase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
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        <property type="entry name" value="ADH_N_2"/>
    </dbReference>
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        <property type="entry name" value="ER"/>
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        <property type="entry name" value="GroES-like_sf"/>
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        <property type="entry name" value="MDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205:SF7">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16884">
        <property type="entry name" value="ADH_N_2"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
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        <location>
            <begin position="20"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF88573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="344" mass="37450" checksum="DBC720B1DC0CAB18" modified="2005-04-26" version="1">MAANKALVFKKIPDGYPVPGEHLTIEPAAYDASAAAPADGVFLQSLYTSFDPYMRGRMRSAEIKSYAPPFYLDKPIESASIAKVIRSNNGSYKEGDLVIGRLPIQEYVAVEKDELSRIRHLENPLGIEDIRVFLGALGMPGLTAYSSLYEIGQPKKGETIFVSAASGAVGQLVGQLAKHEGLKVIGSVGSDEKLNYIINDLGFDGGFNYKKEKPADALARLAPNGIDIYYENVGGEHLEAALEAINNFGRVVVCGMISQYNSAPYPIKNIAYVLTKRLTMRGFIVGDAGMGDKYTKEHQENVQKWIKDGSFKTLIHETEGIENAAEGLVGIFYGKNLGKAVLKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BF85</accession>
    <accession>C8VQI1</accession>
    <name>Q5BF85_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">COX assembly mitochondrial protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ANIA_00795</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for mitochondrial cytochrome c oxidase (COX) assembly and respiration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the CMC family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF88767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_658399.1">
        <property type="nucleotide sequence ID" value="XM_653307.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BF85"/>
    <dbReference type="STRING" id="227321.Q5BF85"/>
    <dbReference type="GeneID" id="2876571"/>
    <dbReference type="KEGG" id="ani:ANIA_00795"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN0795"/>
    <dbReference type="eggNOG" id="ENOG502SDUV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_113403_1_0_1"/>
    <dbReference type="InParanoid" id="Q5BF85"/>
    <dbReference type="OMA" id="WWGLPED"/>
    <dbReference type="OrthoDB" id="6224010at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013892">
        <property type="entry name" value="Cyt_c_biogenesis_Cmc1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22977">
        <property type="entry name" value="COX ASSEMBLY MITOCHONDRIAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22977:SF5">
        <property type="entry name" value="COX ASSEMBLY MITOCHONDRIAL PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08583">
        <property type="entry name" value="Cmc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="114"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU364104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBF88767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="133" mass="15661" checksum="0E3CE505C571374D" modified="2005-04-26" version="1">MTTTNPRYNLRNPLPLSAAQEAEVKQLYYKRVRAYCAPEIKAFAECAVNRTVTATWVCRAQRLAMNSCMIEHAKPEEEDRAREEWFASHEERRRAKLEEQERVEKRREEVIRMMREDEQRKSEAKAKAAGKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BFC2</accession>
    <accession>C8VQX5</accession>
    <name>Q5BFC2_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_00758</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the lysine N-acyltransferase MbtK family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF88843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_658362.1">
        <property type="nucleotide sequence ID" value="XM_653270.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BFC2"/>
    <dbReference type="STRING" id="227321.Q5BFC2"/>
    <dbReference type="GeneID" id="2876533"/>
    <dbReference type="KEGG" id="ani:ANIA_00758"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN0758"/>
    <dbReference type="eggNOG" id="ENOG502RZMI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027095_1_0_1"/>
    <dbReference type="InParanoid" id="Q5BFC2"/>
    <dbReference type="OMA" id="NGAIRHP"/>
    <dbReference type="OrthoDB" id="448427at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016410">
        <property type="term" value="F:N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31438">
        <property type="entry name" value="LYSINE N-ACYLTRANSFERASE C17G9.06C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31438:SF1">
        <property type="entry name" value="LYSINE N-ACYLTRANSFERASE C17G9.06C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13523">
        <property type="entry name" value="Acetyltransf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="285"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="111"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF88843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="496" mass="55605" checksum="BD2DD76D2323AB64" modified="2005-04-26" version="1">MKQKAPLLPLPIGVKVSEVFGGFKFTTKDHAQYNSFPPEWTVCLSTKVARPPNSREPETRAFTTPTLENDRLYLSSLSLPSCEDLKPGSASTRIAAMVLWVTFFWYFQEPEPTPDPSEPPHPSTGPNPTGSWHLIIEPRGILSRKDQIVKVERLGVFASKDSSVGLKKDTIELPQMFISQKAFWELDPRVHLFSISSVMPNPGKSYPAPSGSLDSLGVGFPFGAGPNTSGCFMPPYYPPQALQYTYTGDILHPLRPKAYKQGEVFYVRHIQSGKDYLTLRVPVLPTTDEAPRNRPPGESNGSAPGPDLCLDSEQANDLRLVHEWLRTRPQDTALPRPASIDEHESFLEDRMCSQSSFPVMVCWDSAPTGYCELFWVLEDPVGRVLGDAGGFDRGIRCLMGDKNFLEPKQLKRNISSLIHYCWLHDQRTDTVVLECRANNIEYALSTRVLSNPMLTYCSMISTLETIGLSKVDNVKPPSENNIIMRIHRREWLAPVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BFK9</accession>
    <accession>C8VRS5</accession>
    <name>Q5BFK9_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BZIP transcription factor (Eurofung)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_00671</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF89018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_658275.1">
        <property type="nucleotide sequence ID" value="XM_653183.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BFK9"/>
    <dbReference type="GeneID" id="2876446"/>
    <dbReference type="KEGG" id="ani:ANIA_00671"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN0671"/>
    <dbReference type="eggNOG" id="ENOG502RZFH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020925_1_1_1"/>
    <dbReference type="InParanoid" id="Q5BFK9"/>
    <dbReference type="OMA" id="MRWQIEP"/>
    <dbReference type="OrthoDB" id="4161589at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000093">
        <property type="entry name" value="BZIP transcription factor (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021833">
        <property type="entry name" value="DUF3425"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37012">
        <property type="entry name" value="B-ZIP TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37012:SF2">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11905">
        <property type="entry name" value="DUF3425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="65"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="202"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="114"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="224"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF89018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="552" mass="60895" checksum="E0943F122970ECA8" modified="2005-04-26" version="1">MATRLPPLSDVAPSSALELSSSSLPVIQRPPTTNATAANDSGPVKLEDSPTPVAVTSTSADALCSNPAVGNSNNSPSPVGNAAAGRKRKLNSTSARGVANLTPDQLAKKRANDRQAQRAIRERTKTHIENLEQRVRELSSQKPFLDLQAALKQNEAILAENRELRRGLRAIVDTIQPLLGKQDSIMPPVTAPTTARPTVPLIPSASPPLEVHTLPPNPHRSATVDRSYTESVASVETPSSTHSAPTLGSRRDSAAGNNASLRLAFDYQRHNLLHGLDFGGDERMGFGFLLEPSQQVPKMEGFRRPSEVTRSQSSISSAYSTPLPPVGTVTDQPLPAYMTPVRNIAPTCTLDAILLDFLHNRQREAAKGVPKQKLVGPAYPSVSSLLNPEKSVYSHPLSKVFTDILRTFPDISSLPEQVAVLYSMFLLMRWQIYPTAENYHRLPDWLTPRPSQLLTPHPAWIDYLPWPRMRDRLVMSYHEYPFDNWFIPFTRTLSVNWPYEPTDCLLSTGETDELIINPVFERHFADINNWTLGPAFAEAFPQLVETTKIKPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="115" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BG56</accession>
    <accession>C8VT55</accession>
    <name>Q5BG56_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">uracil phosphoribosyltransferase</fullName>
            <ecNumber evidence="4">2.4.2.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ANIA_00474</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uracil: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UPRTase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.9" evidence="4"/>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF89416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_658078.1">
        <property type="nucleotide sequence ID" value="XM_652986.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BG56"/>
    <dbReference type="STRING" id="227321.Q5BG56"/>
    <dbReference type="GeneID" id="2876254"/>
    <dbReference type="KEGG" id="ani:ANIA_00474"/>
    <dbReference type="eggNOG" id="KOG4203">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067096_1_1_1"/>
    <dbReference type="InParanoid" id="Q5BG56"/>
    <dbReference type="OMA" id="AGACMEQ"/>
    <dbReference type="OrthoDB" id="106623at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004845">
        <property type="term" value="F:uracil phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008655">
        <property type="term" value="P:pyrimidine-containing compound salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000023">
        <property type="entry name" value="Probable uracil phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001097">
        <property type="entry name" value="PRK00129.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14681">
        <property type="entry name" value="UPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="10">
        <location>
            <begin position="96"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF14681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CBF89416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="263" mass="28887" checksum="8FD204E94069905D" modified="2005-04-26" version="1">MTLVKTPSNDQDYFERVTLLRQGNYLLSLMTVIRDELTTSNAFAAAFDRISDLLIAAGSVSKSRSYIRTYPTSTEITAQHSKFSKPADHLSIPIPALDLLPTERLTIRTPTGWTYEGRRQVKPVCGVSILRAGASFETALRRAYGENLSMGKLLIQRNEETSLPVHLYSKLPAGIAEQSVLILEPMLATGGSAIKAIDVLKEKGVCEEDIVFVNLVASKKGLETIMQRFPRLRLVTAAVDEALTVSNHIAPGLGDFGDRFYGT</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-05-26" modified="2026-01-28" version="101" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BH19</accession>
    <accession>C8VQ49</accession>
    <name>CLP1_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">mRNA cleavage and polyadenylation factor clp1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">clp1</name>
        <name type="ORF">AN0161</name>
    </gene>
    <organism>
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for endonucleolytic cleavage during polyadenylation-dependent pre-mRNA 3'-end formation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of a pre-mRNA cleavage factor complex. Interacts directly with PCF11.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Clp1 family. Clp1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">May lack the polyribonucleotide 5'-hydroxyl-kinase and polynucleotide 5'-hydroxyl-kinase activities that are characteristic of the human ortholog.</text>
    </comment>
    <comment type="sequence caution" evidence="3">
        <conflict type="erroneous gene model prediction">
            <sequence resource="EMBL-CDS" id="EAA66034" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EMBL" id="AACD01000005">
        <property type="protein sequence ID" value="EAA66034.1"/>
        <property type="status" value="ALT_SEQ"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF90066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BH19"/>
    <dbReference type="SMR" id="Q5BH19"/>
    <dbReference type="BioGRID" id="1956714">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q5BH19">
        <property type="interactions" value="790"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5BH19"/>
    <dbReference type="EnsemblFungi" id="CBF90066">
        <property type="protein sequence ID" value="CBF90066"/>
        <property type="gene ID" value="ANIA_00161"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AN0161"/>
    <dbReference type="eggNOG" id="KOG2749">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018195_3_1_1"/>
    <dbReference type="InParanoid" id="Q5BH19"/>
    <dbReference type="OMA" id="VQYVNCH"/>
    <dbReference type="OrthoDB" id="258143at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005849">
        <property type="term" value="C:mRNA cleavage factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051731">
        <property type="term" value="F:polynucleotide 5'-hydroxyl-kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002095">
        <property type="entry name" value="mRNA cleavage and polyadenylation factor clp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.1030:FF:000001">
        <property type="entry name" value="Protein CLP1 homolog 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1030">
        <property type="entry name" value="Clp1, DNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.330">
        <property type="entry name" value="Pre-mRNA cleavage complex subunit Clp1, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03035">
        <property type="entry name" value="Clp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028606">
        <property type="entry name" value="Clp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045116">
        <property type="entry name" value="Clp1/Grc3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010655">
        <property type="entry name" value="Clp1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038238">
        <property type="entry name" value="Clp1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032324">
        <property type="entry name" value="Clp1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038239">
        <property type="entry name" value="Clp1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032319">
        <property type="entry name" value="CLP1_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755">
        <property type="entry name" value="CLEAVAGE/POLYADENYLATION FACTOR IA SUBUNIT CLP1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755:SF6">
        <property type="entry name" value="POLYRIBONUCLEOTIDE 5'-HYDROXYL-KINASE CLP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06807">
        <property type="entry name" value="Clp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16573">
        <property type="entry name" value="CLP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16575">
        <property type="entry name" value="CLP1_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0507">mRNA processing</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000375205" description="mRNA cleavage and polyadenylation factor clp1">
        <location>
            <begin position="1"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="410"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="9"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="411"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="155"/>
            <end position="160"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="546" mass="56959" checksum="DE8B420C3175FF0E" modified="2011-11-16" version="2">MSLPGLELTQPSAESQSASAPPTQINLSAGSEWRFEVAFGTTVRVKLLTGTAELFGTELAPSQTYTFSGTKAAIYTWHGCTLEVSAGDAVSGLDGTTSASGRGGLGAGGCQSEYIAEETPMVEYANVHFALEGLRAEAKASGRDGPRVLILGPEDAGKTSLSKILTAYAVKVGREPIVVNLDPTEGMLSVPGTVSATAFRAMLDVEEGWGSSPMSGPSAVPVKLPLVYFYPIVNPLEAEGSVFRPIVSRLALSVMGRMAEDEDAKETGIIVDTPGILSQSRAGALEMINHIVTEFSITTILVIGSERLYSLMMKSYDNKPSSSASSAASDERISVVKLSKSGGCVDRDAAFMKAVRESQIRTYFFGNPVPTTASSALSISSSSTTNVTLSPHAQQLDFDAIALYNYTTSSAEEDQNDEDDYDPAQLTTDSFLPGNNEAESASSLPGLNSAANASAAAAAGALVPLKKVPGPAPSALANTLLAITHASPTSSPSEIRDASTMGFLYVADVDSERGKIRVLAPVGGRVPSRAIIWGKKWPAEVVGLVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BH44</accession>
    <accession>C8VQI7</accession>
    <name>Q5BH44_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ANIA_00136</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF90129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_657740.1">
        <property type="nucleotide sequence ID" value="XM_652648.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BH44"/>
    <dbReference type="GeneID" id="2875912"/>
    <dbReference type="KEGG" id="ani:ANIA_00136"/>
    <dbReference type="HOGENOM" id="CLU_2108984_0_0_1"/>
    <dbReference type="InParanoid" id="Q5BH44"/>
    <dbReference type="OMA" id="LNDWELP"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF90129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="115" mass="12935" checksum="662C15089800B601" modified="2005-04-26" version="1">MASQEQPSQHIQGDARNRTECLGGTLKNWELETANIYLISVDRSTYFFVIALAASQLPIAPRGDAMSSDDLDQVQTWGRKLNDWELPWRKLPGMTSDSCSSLYQLCTSRKNESHG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2010-04-20" modified="2026-01-28" version="118" xmlns="https://uniprot.org/uniprot">
    <accession>Q8NK02</accession>
    <accession>C8VSY4</accession>
    <accession>Q5BG36</accession>
    <name>CBHB_EMENI</name>
    <protein>
        <recommendedName>
            <fullName>1,4-beta-D-glucan cellobiohydrolase B</fullName>
            <ecNumber>3.2.1.91</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Beta-glucancellobiohydrolase B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Exocellobiohydrolase B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Exoglucanase B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">cbhB</name>
        <name type="ORF">AN0494</name>
    </gene>
    <organism>
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Fungal Genet. Biol." volume="37" first="190" last="196">
            <title>Regulation by carbon and nitrogen sources of a family of cellulases in Aspergillus nidulans.</title>
            <authorList>
                <person name="Lockington R.A."/>
                <person name="Rodbourn L."/>
                <person name="Barnett S."/>
                <person name="Carter C.J."/>
                <person name="Kelly J.M."/>
            </authorList>
            <dbReference type="PubMed" id="12409103"/>
            <dbReference type="DOI" id="10.1016/S1087-1845(02)00504-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="11417" last="11422">
            <title>Development and application of a suite of polysaccharide-degrading enzymes for analyzing plant cell walls.</title>
            <authorList>
                <person name="Bauer S."/>
                <person name="Vasu P."/>
                <person name="Persson S."/>
                <person name="Mort A.J."/>
                <person name="Somerville C.R."/>
            </authorList>
            <dbReference type="PubMed" id="16844780"/>
            <dbReference type="DOI" id="10.1073/pnas.0604632103"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="1 5">The biological conversion of cellulose to glucose generally requires three types of hydrolytic enzymes: (1) Endoglucanases which cut internal beta-1,4-glucosidic bonds; (2) Exocellobiohydrolases that cut the disaccharide cellobiose from the non-reducing end of the cellulose polymer chain; (3) Beta-1,4-glucosidases which hydrolyze the cellobiose and other short cello-oligosaccharides to glucose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>Hydrolysis of (1-&gt;4)-beta-D-glucosidic linkages in cellulose and cellotetraose, releasing cellobiose from the non-reducing ends of the chains.</text>
            <dbReference type="EC" id="3.2.1.91"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the glycosyl hydrolase 7 (cellulase C) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.91"/>
    <dbReference type="EMBL" id="AF420020">
        <property type="protein sequence ID" value="AAM54070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AACD01000007">
        <property type="protein sequence ID" value="EAA66593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF89371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_658098.1">
        <property type="nucleotide sequence ID" value="XM_653006.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8NK02"/>
    <dbReference type="SMR" id="Q8NK02"/>
    <dbReference type="STRING" id="227321.Q8NK02"/>
    <dbReference type="CAZy" id="CBM1">
        <property type="family name" value="Carbohydrate-Binding Module Family 1"/>
    </dbReference>
    <dbReference type="CAZy" id="GH7">
        <property type="family name" value="Glycoside Hydrolase Family 7"/>
    </dbReference>
    <dbReference type="GlyCosmos" id="Q8NK02">
        <property type="glycosylation" value="2 sites, No reported glycans"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CBF89371">
        <property type="protein sequence ID" value="CBF89371"/>
        <property type="gene ID" value="ANIA_00494"/>
    </dbReference>
    <dbReference type="GeneID" id="2876273"/>
    <dbReference type="KEGG" id="ani:ANIA_00494"/>
    <dbReference type="eggNOG" id="ENOG502QPHV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020817_3_2_1"/>
    <dbReference type="InParanoid" id="Q8NK02"/>
    <dbReference type="OMA" id="CGFNGAL"/>
    <dbReference type="OrthoDB" id="412382at2759"/>
    <dbReference type="BRENDA" id="3.2.1.91">
        <property type="organism ID" value="517"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016162">
        <property type="term" value="F:cellulose 1,4-beta-cellobiosidase activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="CDD" id="cd07999">
        <property type="entry name" value="GH7_CBH_EG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.100.10:FF:000001">
        <property type="entry name" value="Glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.100.10">
        <property type="entry name" value="Glycoside hydrolase, family 7, domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001722">
        <property type="entry name" value="Glyco_hydro_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037019">
        <property type="entry name" value="Glyco_hydro_7_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33753">
        <property type="entry name" value="1,4-BETA-D-GLUCAN CELLOBIOHYDROLASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33753:SF2">
        <property type="entry name" value="GLYCOSIDE HYDROLASE FAMILY 7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00840">
        <property type="entry name" value="Glyco_hydro_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00734">
        <property type="entry name" value="GLHYDRLASE7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword id="KW-0136">Cellulose degradation</keyword>
    <keyword id="KW-1015">Disulfide bond</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0326">Glycosidase</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0624">Polysaccharide degradation</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000393550" description="1,4-beta-D-glucan cellobiohydrolase B">
        <location>
            <begin position="24"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="3">
        <location>
            <begin position="490"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Catalytic">
        <location>
            <begin position="24"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Ser/Thr-rich linker">
        <location>
            <begin position="459"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="464"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="468"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="235"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="240"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="293"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="400"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="498"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="509"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="16844780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="6"/>
    <sequence length="526" mass="56123" checksum="9A9CD7C5BEBCB6C9" modified="2002-10-01" version="1" precursor="true">MASSFQLYKALLFFSSLLSAVQAQKVGTQQAEVHPGLTWQTCTSSGSCTTVNGEVTIDANWRWLHTVNGYTNCYTGNEWDTSICTSNEVCAEQCAVDGANYASTYGITTSGSSLRLNFVTQSQQKNIGSRVYLMDDEDTYTMFYLLNKEFTFDVDVSELPCGLNGAVYFVSMDADGGKSRYATNEAGAKYGTGYCDSQCPRDLKFINGVANVEGWESSDTNPNGGVGNHGSCCAEMDIWEANSISTAFTPHPCDTPGQTLCTGDSCGGTYSNDRYGGTCDPDGCDFNSYRQGNKTFYGPGLTVDTNSPVTVVTQFLTDDNTDTGTLSEIKRFYVQNGVVIPNSESTYPANPGNSITTEFCESQKELFGDVDVFSAHGGMAGMGAALEQGMVLVLSLWDDNYSNMLWLDSNYPTDADPTQPGIARGTCPTDSGVPSEVEAQYPNAYVVYSNIKFGPIGSTFGNGGGSGPTTTVTTSTATSTTSSATSTATGQAQHWEQCGGNGWTGPTVCASPWACTVVNSWYSQCL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2016-06-08" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>A7XRY8</accession>
    <accession>C8VEN5</accession>
    <accession>Q5AT61</accession>
    <accession>Q5AT64</accession>
    <name>TDID_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Aminotransferase tdiD</fullName>
            <ecNumber evidence="4">2.6.1.28</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Terrequinone biosynthesis protein D</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">tdiD</name>
        <name type="ORF">AN8516</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2007" name="Nat. Chem. Biol." volume="3" first="584" last="592">
            <title>Terrequinone A biosynthesis through L-tryptophan oxidation, dimerization and bisprenylation.</title>
            <authorList>
                <person name="Balibar C.J."/>
                <person name="Howard-Jones A.R."/>
                <person name="Walsh C.T."/>
            </authorList>
            <dbReference type="PubMed" id="17704773"/>
            <dbReference type="DOI" id="10.1038/nchembio.2007.20"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA]</scope>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>BIOPHYSICOCHEMICAL PROPERTIES</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2006" name="Chem. Biol." volume="13" first="31" last="37">
            <title>Genomic mining for Aspergillus natural products.</title>
            <authorList>
                <person name="Bok J.W."/>
                <person name="Hoffmeister D."/>
                <person name="Maggio-Hall L.A."/>
                <person name="Murillo R."/>
                <person name="Glasner J.D."/>
                <person name="Keller N.P."/>
            </authorList>
            <dbReference type="PubMed" id="16426969"/>
            <dbReference type="DOI" id="10.1016/j.chembiol.2005.10.008"/>
        </citation>
        <scope>IDENTIFICATION</scope>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2007" name="Fungal Genet. Biol." volume="44" first="1134" last="1145">
            <title>Accurate prediction of the Aspergillus nidulans terrequinone gene cluster boundaries using the transcriptional regulator LaeA.</title>
            <authorList>
                <person name="Bouhired S."/>
                <person name="Weber M."/>
                <person name="Kempf-Sontag A."/>
                <person name="Keller N.P."/>
                <person name="Hoffmeister D."/>
            </authorList>
            <dbReference type="PubMed" id="17291795"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2006.12.010"/>
        </citation>
        <scope>IDENTIFICATION</scope>
        <scope>INDUCTION</scope>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2008" name="Fungal Genet. Biol." volume="45" first="302" last="309">
            <title>The Aspergillus nidulans enzyme TdiB catalyzes prenyltransfer to the precursor of bioactive asterriquinones.</title>
            <authorList>
                <person name="Schneider P."/>
                <person name="Weber M."/>
                <person name="Hoffmeister D."/>
            </authorList>
            <dbReference type="PubMed" id="18029206"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2007.09.004"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2012" name="Appl. Microbiol. Biotechnol." volume="93" first="2011" last="2022">
            <title>Heterologous expression system in Aspergillus oryzae for fungal biosynthetic gene clusters of secondary metabolites.</title>
            <authorList>
                <person name="Sakai K."/>
                <person name="Kinoshita H."/>
                <person name="Nihira T."/>
            </authorList>
            <dbReference type="PubMed" id="22083274"/>
            <dbReference type="DOI" id="10.1007/s00253-011-3657-9"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="2 3 4 5 6">Aminotransferase; part of the gene cluster that mediates the biosynthesis of terrequinone A, an antitumor agent (PubMed:16426969, PubMed:17291795, PubMed:17704773, PubMed:22083274). The first step in the biosynthetic pathway for terrequinone A is formation of indole pyruvic acid (IPA) from L-tryptophan by the aminotransferase tdiD (PubMed:17704773). The nonribosomal peptide synthase tdiA then immediately converts unstable IPA to didemethylasterriquinone D (DDAQ D), via condensation of 2 IPA molecules (PubMed:17704773). The symmetric connectivity of the 2 IPA molecules is thought to arise by head-to-tail dual Claisen condensations facilitated by the TE domain (PubMed:17704773). TdiB then catalyzes reverse prenylation by transferring dimethylallyl diphosphate to carbon atom 2' of DDAQ D, to yield asterriquinone C-1 (PubMed:18029206). Finally, tdiC and tdiE enzymes robustly convert asterriquinone C-1 to terrequinone A via a transformation involving regular prenylation at carbon atom 5, which requires elimination of the hydroxy group on C-5 (PubMed:17704773, PubMed:18029206).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>3-phenylpyruvate + L-tryptophan = indole-3-pyruvate + L-phenylalanine</text>
            <dbReference type="Rhea" id="RHEA:13741"/>
            <dbReference type="ChEBI" id="CHEBI:17640"/>
            <dbReference type="ChEBI" id="CHEBI:18005"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="EC" id="2.6.1.28"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:13742"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="biophysicochemical properties">
        <kinetics>
            <KM evidence="4">198 uM for L-tryptophan</KM>
        </kinetics>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="induction">
        <text evidence="2 3">Expression is positively regulated by the secondary metabolism regulator laeA (PubMed:16426969, PubMed:17291795).</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="sequence caution" evidence="8">
        <conflict type="erroneous gene model prediction">
            <sequence resource="EMBL-CDS" id="CBF80716" version="1"/>
        </conflict>
    </comment>
    <comment type="sequence caution" evidence="8">
        <conflict type="erroneous gene model prediction">
            <sequence resource="EMBL-CDS" id="EAA66860" version="1"/>
        </conflict>
    </comment>
    <comment type="sequence caution" evidence="8">
        <conflict type="erroneous gene model prediction">
            <sequence resource="EMBL-CDS" id="EAA66872" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EC" id="2.6.1.28" evidence="4"/>
    <dbReference type="EMBL" id="EF550584">
        <property type="protein sequence ID" value="ABU51605.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF80716.1"/>
        <property type="status" value="ALT_SEQ"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AACD01000154">
        <property type="protein sequence ID" value="EAA66860.1"/>
        <property type="status" value="ALT_SEQ"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AACD01000155">
        <property type="protein sequence ID" value="EAA66872.1"/>
        <property type="status" value="ALT_SEQ"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_681785.1">
        <property type="nucleotide sequence ID" value="XM_676693.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A7XRY8"/>
    <dbReference type="SMR" id="A7XRY8"/>
    <dbReference type="STRING" id="227321.A7XRY8"/>
    <dbReference type="KEGG" id="ani:ANIA_08516"/>
    <dbReference type="eggNOG" id="KOG0634">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="A7XRY8"/>
    <dbReference type="OrthoDB" id="691673at2759"/>
    <dbReference type="BioCyc" id="MetaCyc:MONOMER-18726"/>
    <dbReference type="BRENDA" id="2.6.1.28">
        <property type="organism ID" value="517"/>
    </dbReference>
    <dbReference type="SABIO-RK" id="A7XRY8"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070529">
        <property type="term" value="F:L-tryptophan aminotransferase activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047299">
        <property type="term" value="F:tryptophan-phenylpyruvate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901605">
        <property type="term" value="P:alpha-amino acid metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900796">
        <property type="term" value="P:terrequinone A biosynthetic process"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050859">
        <property type="entry name" value="Class-I_PLP-dep_aminotransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790:SF19">
        <property type="entry name" value="KYNURENINE_ALPHA-AMINOADIPATE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0032">Aminotransferase</keyword>
    <keyword id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000436367" description="Aminotransferase tdiD">
        <location>
            <begin position="1"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>substrate</name>
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    <feature type="binding site" evidence="1">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>substrate</name>
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    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="407"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="1">
        <location>
            <position position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="Q8N5Z0"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="16426969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="17291795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="17704773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="18029206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="6">
        <source>
            <dbReference type="PubMed" id="22083274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="7">
        <source>
            <dbReference type="PubMed" id="16426969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="8"/>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABU51605.1"/>
        </source>
    </evidence>
    <sequence length="436" mass="47705" checksum="015F606F1A48EDD8" modified="2007-10-23" version="1">MGSIGANNAVADPTPLFSSRVQKWEPGAIRSLLPLEALPGMISLVAGKPSPETFPIAEIAISLKDTPAGTGRIVVDGDELNQALQYGLPRGNAQLIQWFESLQRSVHGLDENGGWSCCIGNGSQELIHRVIQVFTDPGDPVLLETPAYPGVAGFLRADGQELIPVYSDAQGLNPASLEQALSEWPGDSPRPKVLYTTPTGSNPTGQSCTESRKAEILRLAKRFNFIILEDDAYYYLNYGDDKQRARSYLALERDVNGESGRVVRFDSLSKIVSPGMRLGILTAQAAVVDKVVRITENINLQPSSTTQLLALSLLRHWGQAGFLKHCAEAAEVYRRRRDVFVSAAERHLQGRATWVVPTAGMFVWLELKLPPEMDSFELLKSQGMKNGVLAIPGVAFMPGNEQTCYIRVSFSLVPERDMDEACRRIAGLVDRCACHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>C8V000</accession>
    <name>C8V000_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF3824 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_10736</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF70696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467074.1">
        <property type="nucleotide sequence ID" value="XM_050612676.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V000"/>
    <dbReference type="STRING" id="227321.C8V000"/>
    <dbReference type="GeneID" id="2871068"/>
    <dbReference type="KEGG" id="ani:ANIA_10736"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN10736"/>
    <dbReference type="eggNOG" id="ENOG502QW3V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_577497_0_0_1"/>
    <dbReference type="InParanoid" id="C8V000"/>
    <dbReference type="OMA" id="MMPGEAD"/>
    <dbReference type="OrthoDB" id="3561737at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024436">
        <property type="entry name" value="DUF3824"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35487">
        <property type="entry name" value="DUF3824 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35487:SF1">
        <property type="entry name" value="DUF3824 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12868">
        <property type="entry name" value="DUF3824"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3824" evidence="2">
        <location>
            <begin position="31"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3824" evidence="2">
        <location>
            <begin position="175"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="184"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="282"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="385"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="419"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="438"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF70696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="473" mass="52425" checksum="88FF133F6B2F1F45" modified="2009-11-03" version="1">MAEAGLAGAAVAGLVERARSHSRSRNRSRSRSKSRIRKALPVVAAGLGSAVAANIWDKKKDKEAEEEPRRKDRHRSRSRGRAPSDIYPDSTRDSAGLIEYGDHPVHGSIPAANYYGRPPSSPGYHTDASDRVARDAGLGSGHRGRTRSRSRSRARFSSSSPSSEEDRRRRRSRHRHRSRSRDLAGAALAATGVGYAAHKYSQHRKEDKERDRQRYDSDGPSLFEQPFSPGPYPPSPGTGPVDSSQYRPNNYYPPPPGPAPAPAPGPAHYNPADYPPPPNAVPPQQYSYPPPAADAYAPRPRRADENVSAARDFSSPSTQSQPYDGLDSTRLATPRPRSRRRRTRAGSEPPQSKSVAFDDDPQTNEKTTGYETDDSDSTVDGMSSGRRRRRRHHRRHRSDRRRYSSSDPYASSAKDRSAAQIQKQTSAPESDSDATIDLPDRFDRDGRLLPQPGDDPLAEKVESLLRKFNRVFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>C8V2K5</accession>
    <name>C8V2K5_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cytochrome P450, putative (Eurofung)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ANIA_06101</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF70183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_663705.2">
        <property type="nucleotide sequence ID" value="XM_658613.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V2K5"/>
    <dbReference type="GeneID" id="2870775"/>
    <dbReference type="KEGG" id="ani:ANIA_06101"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN6101"/>
    <dbReference type="eggNOG" id="KOG0157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_14_10_1"/>
    <dbReference type="InParanoid" id="C8V2K5"/>
    <dbReference type="OMA" id="WSYEKVK"/>
    <dbReference type="OrthoDB" id="6692864at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11061">
        <property type="entry name" value="CYP67-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000129">
        <property type="entry name" value="Benzoate 4-monooxygenase cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF78">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="2">
        <location>
            <position position="506"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBF70183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="562" mass="63435" checksum="29E9015658A8902F" modified="2009-11-03" version="1">MNSLLFREALQHASSTDISKLLLSAATLGVLSHVSLFRSLPVEEYLYGLLGLYTATVVAVTVLYLTATAFSPLQVLLRVGCISAAFNTGLASSIAIYRLFFHRLRRFPGPRLSKLSRFYDAYLAGKGLQYHVEIAEMHKRYGDFFRTGPREICIVRKSAVPLLLSPQSKCGKSTFYAQAQTEAEYCNVHQTRDFEDHRRRRKAWDRGLSVKALATYEPSIRAKADLLVLHIEKNRGRAIDATKWSMFLSFDIMGKVGFGKEFNNLSTGVEHPGIKAIHDHMAILGVMCHVPWLLNLISNLPGASFSMAEFFKWCEDEIVQKHRSWDIKETPQDITSWLLKAYVHKEVSAAPTANALHEDSRAVIVAGSETTATTLASILYFLCKNPEILAKLQLLLDEAMPGGSSEWTYDKIKTISYLDDIINETLRLRPAILTGGYRVTPAEGLQVDEVYIPGDVNVFVPTQLIQTDERYYVDAKRFVPERWNEKKEMIQDGAPYFPFLYGPYVCPKKNLALMSLRISVSKLAQLYDIHFAPGENGELFETRTLDTFTTTLPPLHVQFLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C8V2U3</accession>
    <name>C8V2U3_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein YOP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_06059</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF70269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467018.1">
        <property type="nucleotide sequence ID" value="XM_050612091.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V2U3"/>
    <dbReference type="STRING" id="227321.C8V2U3"/>
    <dbReference type="GeneID" id="2871028"/>
    <dbReference type="KEGG" id="ani:ANIA_06059"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN6059"/>
    <dbReference type="eggNOG" id="KOG1726">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048918_0_0_1"/>
    <dbReference type="InParanoid" id="C8V2U3"/>
    <dbReference type="OMA" id="WMPWGWG"/>
    <dbReference type="OrthoDB" id="434647at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004345">
        <property type="entry name" value="TB2_DP1_HVA22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12300">
        <property type="entry name" value="HVA22-LIKE PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12300:SF177">
        <property type="entry name" value="PROTEIN YOP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03134">
        <property type="entry name" value="TB2_DP1_HVA22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="248"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="265"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU362006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF70269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="320" mass="35974" checksum="BAC068010EEDA6D2" modified="2009-11-03" version="1">MFFGIFADLLSSILTILFPIFASYKALRSSDPYQLAPWLMYWVVLSAILMAESWTYFIIGWIPFYSWIRLGFFAYLVLPQTQGARILYQDYVEPFLAHHEREIEEFIGRAHERAKALGLQYLYQAIDFVRERVLGLPPQRPPTPPPASAASYAQSLLSRFNLPSAVGGTNPAPANDWYSAISSAVAAVTSPGKSHESRADELSASGSLLPREFESKTRAEKASFYSKQRDMLDVLRNALINEERNLEHAEEDPLAYGGGAPLRKNRSDNSFDHIEHEDTRDRSPRRSGNWFGDGEQTGAASGVEFAMRTVDAIARAREAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>C8V3I9</accession>
    <name>C8V3I9_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thiamin biosynthesis protein (Thi-4), putative (AFU_orthologue AFUA_2G10740)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_10762</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF70540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467046.1">
        <property type="nucleotide sequence ID" value="XM_050612451.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V3I9"/>
    <dbReference type="FunCoup" id="C8V3I9">
        <property type="interactions" value="696"/>
    </dbReference>
    <dbReference type="STRING" id="227321.C8V3I9"/>
    <dbReference type="GeneID" id="2871177"/>
    <dbReference type="KEGG" id="ani:ANIA_10762"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN10762"/>
    <dbReference type="eggNOG" id="KOG2598">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020520_2_1_1"/>
    <dbReference type="InParanoid" id="C8V3I9"/>
    <dbReference type="OMA" id="FWEMFPY"/>
    <dbReference type="OrthoDB" id="10028886at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008902">
        <property type="term" value="F:hydroxymethylpyrimidine kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008972">
        <property type="term" value="F:phosphomethylpyrimidine kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050334">
        <property type="term" value="F:thiaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="CDD" id="cd01169">
        <property type="entry name" value="HMPP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19367">
        <property type="entry name" value="TenA_C_ScTHI20-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.910.10:FF:000003">
        <property type="entry name" value="Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase THI20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1190.20:FF:000034">
        <property type="entry name" value="Putative hydroxymethylpyrimidine/ phosphomethylpyrimidine kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.910.10">
        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016084">
        <property type="entry name" value="Haem_Oase-like_multi-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004399">
        <property type="entry name" value="HMP/HMP-P_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013749">
        <property type="entry name" value="PM/HMP-P_kinase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004305">
        <property type="entry name" value="Thiaminase-2/PQQC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027574">
        <property type="entry name" value="Thiaminase_II"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00097">
        <property type="entry name" value="HMP-P_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR04306">
        <property type="entry name" value="salvage_TenA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20858:SF17">
        <property type="entry name" value="HYDROXYMETHYLPYRIMIDINE_PHOSPHOMETHYLPYRIMIDINE KINASE THI20-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20858">
        <property type="entry name" value="PHOSPHOMETHYLPYRIMIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08543">
        <property type="entry name" value="Phos_pyr_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03070">
        <property type="entry name" value="TENA_THI-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48613">
        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyridoxamine kinase/Phosphomethylpyrimidine kinase" evidence="2">
        <location>
            <begin position="13"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="Thiaminase-2/PQQC" evidence="1">
        <location>
            <begin position="299"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF70540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="510" mass="55416" checksum="7AF77D8B2CDB2BFA" modified="2009-11-03" version="1">MSVGRVLVIAGSDSSGGAGLEADQRVLTAHGCYALTATTGLTAQNTLGVQDIFVVPADFVEKQIRAGLDDVGADVVKLGMLSSATTIDVVADALTSYQIPSVVLDPVMISTSGSQLLPEAAVQGLRTKLLPLTTILTPNIPEAQLLLKDAGQEPTNPEDLQGLIDLAKRVAALGPRAVLLKGGHLPLTKDYTAAKGSDDASRVIDILYAGEEVTQFETEYLVSKNTHGTGCSLASAIAANLALGKDLKRAVRNGVRFVEAGIKTSYDIGKGSGPINHFHSVYSLPFAPGRFLEYVLDRPDVQSVWKRFTEHEFVLGLGSGTLPVERFKEYLVQDYLYLVQFARSNALASYKAKDMESIAASAKIVLHIQQETALHIDYCASFGLSKEEMEKVPETTACTAYSRYILDVGQSEDWLALQVALAPCLIGYGAIAQRLHAEEKTLREGNRYWKWIENYVAEDYTEAVRLGSELLETHMRKVSLSRMEELVKIFIKATELEIMFWDMGLGAGHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>C8V582</accession>
    <name>C8V582_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylesterase type B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ANIA_07947</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF73577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_681216.2">
        <property type="nucleotide sequence ID" value="XM_676124.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V582"/>
    <dbReference type="STRING" id="227321.C8V582"/>
    <dbReference type="GeneID" id="2869117"/>
    <dbReference type="KEGG" id="ani:ANIA_07947"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN7947"/>
    <dbReference type="eggNOG" id="KOG1516">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086412_0_0_1"/>
    <dbReference type="InParanoid" id="C8V582"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050654">
        <property type="entry name" value="AChE-related_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918">
        <property type="entry name" value="ACETYLCHOLINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918:SF4">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="3">
        <location>
            <begin position="50"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBF73577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="281" mass="31442" checksum="7B7B6038D5C3B96B" modified="2009-11-03" version="1">MVLTPACTLPSSTKTFFWGFTIFRPLYHLRPRHWHQRVGFQITAYAGRNDSLFRAAIMQSGNPVPEKGLNGTQYFQPLYDAIAQRVVPITSYALANDMAANDTCWDVDRMACLRNMDFEQMNDAINATSARAWFPVIDGDIVPEQPSRSLYTGKKYVKVPIILGASTDEGSKYMPEQNVTKEEEFVDLVANPQSYGVTPGIALPKILVRQLTEAYANISSSPCDAAIDANRRQACSTWSRANTSTYCYRFNVPLHDQNTAQQGNELPFVFANTEELGTNTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>C8V607</accession>
    <name>C8V607_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BYS1 domain protein, putative (AFU_orthologue AFUA_5G01990)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ANIA_08043</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF73764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_681312.2">
        <property type="nucleotide sequence ID" value="XM_676220.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V607"/>
    <dbReference type="SMR" id="C8V607"/>
    <dbReference type="STRING" id="227321.C8V607"/>
    <dbReference type="GeneID" id="2869278"/>
    <dbReference type="KEGG" id="ani:ANIA_08043"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN8043"/>
    <dbReference type="eggNOG" id="ENOG502SP0S">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083650_1_1_1"/>
    <dbReference type="InParanoid" id="C8V607"/>
    <dbReference type="OMA" id="CGAIEWA"/>
    <dbReference type="OrthoDB" id="3682664at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006771">
        <property type="entry name" value="CetA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36195:SF4">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G01990)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36195">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G01990)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04681">
        <property type="entry name" value="Bys1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF73764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="203" mass="21803" checksum="64AC6B2A3B793E58" modified="2009-11-03" version="1">MQSLCAPNLYKDDFSPLNGISKSRPQYHKSSTASSTDTVIPHLKMHFTSLAAVAITALAPLASAVGNAKVHNNCAAPFYLWSVGSSVSNVHKINPGETFSEQFHRDAVTGGIALKITRQSDGLYNGSPQLIFAYTLDPSQVWYDLSTIFGTDFQGQVLTVTSNNEDCPTICWPDGTQPAGSQVKTCEPNSDQTLTLCADECPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>C8V6W9</accession>
    <name>C8V6W9_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ANIA_11591</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF74002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467265.1">
        <property type="nucleotide sequence ID" value="XM_050611216.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V6W9"/>
    <dbReference type="GeneID" id="74897154"/>
    <dbReference type="KEGG" id="ani:ANIA_11591"/>
    <dbReference type="HOGENOM" id="CLU_3384739_0_0_1"/>
    <dbReference type="InParanoid" id="C8V6W9"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF74002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="33" mass="3563" checksum="F69A85018DCB25B4" modified="2009-11-03" version="1">MSSFILSAFSLPCCKPSSTDSSNIKICIYKGFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C8V723</accession>
    <name>C8V723_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sidoreflexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ANIA_10445</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the sideroflexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF75419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467452.1">
        <property type="nucleotide sequence ID" value="XM_050611421.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V723"/>
    <dbReference type="FunCoup" id="C8V723">
        <property type="interactions" value="285"/>
    </dbReference>
    <dbReference type="STRING" id="227321.C8V723"/>
    <dbReference type="GeneID" id="74896404"/>
    <dbReference type="KEGG" id="ani:ANIA_10445"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN10445"/>
    <dbReference type="eggNOG" id="KOG3767">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039425_0_0_1"/>
    <dbReference type="InParanoid" id="C8V723"/>
    <dbReference type="OMA" id="GRVRHCA"/>
    <dbReference type="OrthoDB" id="6608471at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015194">
        <property type="term" value="F:L-serine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0015075">
        <property type="term" value="F:monoatomic ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071454">
        <property type="term" value="P:cellular response to anoxia"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990542">
        <property type="term" value="P:mitochondrial transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140300">
        <property type="term" value="P:serine import into mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004686">
        <property type="entry name" value="Mtc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00798">
        <property type="entry name" value="mtc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11153">
        <property type="entry name" value="SIDEROFLEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11153:SF6">
        <property type="entry name" value="SIDEROFLEXIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03820">
        <property type="entry name" value="SFXNs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="274"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBF75419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="327" mass="35405" checksum="BA4B97A7F7DF0509" modified="2009-11-03" version="1">MSASLPGDRELPHSQYDLNTYWGRVRHAADISDPRMLFVSSAGLEQAKRLISSYKQNEVPTMNAELWRAKKVVDSTLHPDTGEPVFLPFRMSCYVLSNLVVTAGMLTPGLKTTGTLLWQIANQSLNVAINNANSNKSTPLSVSQMAKSYLMAVSASCSVALGLNALVPRLKNVSPNTKLILGRLVPFAAVSSASALNVFLMRSEEIRQGIDVYPVPEKEGEPVQSLGRSKVAAKIAVGETAISRVLNATPIMVVPPLILVQLEKRKLLSPRMVLPANLGLVLATSLFALPLALGAFPQRQAISAASLEEEFWNRGGKDGKVEFNRGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C8V8J8</accession>
    <name>C8V8J8_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">3-oxo-5-alpha-steroid 4-dehydrogenase family protein (AFU_orthologue AFUA_4G07350)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_10559</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF77510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467723.1">
        <property type="nucleotide sequence ID" value="XM_050611730.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V8J8"/>
    <dbReference type="STRING" id="227321.C8V8J8"/>
    <dbReference type="GeneID" id="74896475"/>
    <dbReference type="KEGG" id="ani:ANIA_10559"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN10559"/>
    <dbReference type="eggNOG" id="KOG1638">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065395_0_0_1"/>
    <dbReference type="InParanoid" id="C8V8J8"/>
    <dbReference type="OMA" id="PHYALEW"/>
    <dbReference type="OrthoDB" id="5788137at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039357">
        <property type="entry name" value="SRD5A/TECR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10556">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10556:SF43">
        <property type="entry name" value="STEROID 5-ALPHA-REDUCTASE DET2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50244">
        <property type="entry name" value="S5A_REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="131"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF77510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="402" mass="43382" checksum="B70F370A849EF117" modified="2009-11-03" version="1">MGSFLSSTLNGLPPLRDFILPTPEAYVILLNIWQYFPLITVAQWLTAWHPAGKTSKDSILNIPGRIAWFAMEIVGPINLLYILTTLPAKLPTLDIRTLPLTNKLVASLYVLHYVNRAVISPFFTAPSMSPIHVFIAVSAAAFNWVNSTCLACWLVGYNVTTVPGYYPTSGLGAAEAALMTPEKVLEDSLSSTVGTSLVIPAVGLVLFFVGMAGNIYAERTLFALRREAADKQASQTSANGADAKESTDGKKPNKYHKVYVIPPKSGLFASILYPHYVLEWLEWTGFALVGTTVFPALSPPSLIPDVLSTSFRSTTGGIPGFGLGLGASRTSYGAASAPASTVHLAPWLIPAVWAAGKMRLPVLPLPAMVFVVNAVSNMLPHARWGRKWYVERFGGGERWCGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C8V8S4</accession>
    <name>C8V8S4_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Nuclear pore complex protein An-Ndc1 (Eurofung)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">ANIA_04417</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="16">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NDC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF77569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467732.1">
        <property type="nucleotide sequence ID" value="XM_050611739.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V8S4"/>
    <dbReference type="STRING" id="227321.C8V8S4"/>
    <dbReference type="GeneID" id="2872213"/>
    <dbReference type="KEGG" id="ani:ANIA_04417"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN4417"/>
    <dbReference type="eggNOG" id="ENOG502S1MG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029386_1_0_1"/>
    <dbReference type="InParanoid" id="C8V8S4"/>
    <dbReference type="OMA" id="WQTANLF"/>
    <dbReference type="OrthoDB" id="67850at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070762">
        <property type="term" value="C:nuclear pore transmembrane ring"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106166">
        <property type="term" value="F:spindle pole body-nuclear membrane anchor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006999">
        <property type="term" value="P:nuclear pore organization"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070631">
        <property type="term" value="P:spindle pole body localization"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019049">
        <property type="entry name" value="Nucleoporin_prot_Ndc1/Nup"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13269">
        <property type="entry name" value="NUCLEOPORIN NDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13269:SF6">
        <property type="entry name" value="NUCLEOPORIN NDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09531">
        <property type="entry name" value="Ndc1_Nup"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="10" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="44"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="207"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="262"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="373"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="416"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CBF77569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="650" mass="72214" checksum="7D8C513F761A0A95" modified="2009-11-03" version="1">MAAKPRPYRRILTSALHRRFVHASALSLLVCYAISVLIGDKSSLFWALFPLGSCGIRTILLFISPLAIFVLRVGQMHIGSRTTSSSLNTFHYLFPLHVIQTFGWYIFSAWWFSELYKWSAPTSAHLEWVKRGSPHERATLNERTIYIYTYHLLLAIAQSLAHLYNDYDRVPIAITDKPVGGADQKTHPTQPISKRLQEGLHQTLRDGLFRSTVVALVCPVAYVFFLRRRAWTYTMSFAKLFWDFPRSAADPPSLILPVKPPLIARTIFSGALLVLCWQTTNLFFSMFLSQEPVKRGQPLTSGAKDPTGSLLNGLKAKKETVRAFAFWELCFISQQFPDRRKAIFNDIDREGGSAWTQIMQSATEVIQGITSRINEQKLGPAKSKPSPAETKSEPTLRTLPRLTDPVKEGNIFAASPRSTTTNGRLGEGFSSTLRSLGESPDWTPKARARARDVFDRASSAVLSPERKQKLLSSSQDFKLLTGASSTRPESIHPFLAQLLRSPIGLLIRQPFARRLSGIVLGTPTASLSSIIDAIESITRLLIASLNEDPYGKVQADVPAIVSLFTETLTTLDTYAHVELDVHWTDAAFPPSNDPAAQAAARRVPDVELIIDSLRASLKSLLTAFSPYFKDVGLVGKELRLAKGAAGFDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C8V938</accession>
    <name>C8V938_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Pentafunctional AROM polypeptide, putative (AFU_orthologue AFUA_4G06460)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ANIA_10544</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF77705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467744.1">
        <property type="nucleotide sequence ID" value="XM_050611756.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V938"/>
    <dbReference type="STRING" id="227321.C8V938"/>
    <dbReference type="GeneID" id="74896467"/>
    <dbReference type="KEGG" id="ani:ANIA_10544"/>
    <dbReference type="eggNOG" id="KOG0692">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009960_0_0_1"/>
    <dbReference type="InParanoid" id="C8V938"/>
    <dbReference type="OMA" id="AINAHCV"/>
    <dbReference type="OrthoDB" id="197068at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003855">
        <property type="term" value="F:3-dehydroquinate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00502">
        <property type="entry name" value="DHQase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000135">
        <property type="entry name" value="Pentafunctional AROM polypeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001381">
        <property type="entry name" value="DHquinase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050068">
        <property type="entry name" value="MurA_subfamily"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01093">
        <property type="entry name" value="aroD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43783">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43783:SF1">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01487">
        <property type="entry name" value="DHquinase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF77705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="688" mass="75122" checksum="B4D6AA7A331FE657" modified="2009-11-03" version="1">MQTAVHHQPVATTLRADSPVSVASTSLKGTSASAALPFPQALPQEPSRTVVAVYGPGQDAIVQVVADILGKPWTTETSLSTLGRGSSAVVVGIRATDLPGSLDGCDKSACMLVNLHCVDDGSFPEEGLTELCDYEFLYSLRSPFFRRDLTRFLSLILGQTRPHEDLKTKNRTNFISTTFPDVHAALPNLDILSVGSDAVEIRVDLLVDPDPLPQDQGYPGIPSLRYVGQQLMLLRQHTELPIIFTTRCTKENGKFPMDNPALFYRYLRRAIQWGVEYIDVELWLPEDIRRKLAEVKGNSVIMSAFHDFSGEWKWTSPEAPRIFEESAKYADIVKMIAMVDSVEANYELEYFRSTIKQTHGTYPLLSAVNMGQLGQLSRALNTVFSPITHPLLPMIAAPGQLTAAEINEALHIMGQLPKRDLYAIGSFRATPQSMFMEKCFNELSLPHTLTSMDRGPAGSLERVFSQPSFGGAALHPPLSSTSHLPAISDAARAIGLVDTIVVTSPGSLVGENATWKGIRATLTRDYVPSAYRGRAAIILAGSESEASASIFALRSLGVGAIYTVGFRATGPLAEGLEPFTSIQSVKLVEQPFVIVSALPPEKSLLVQPLLRHYRSTGRASPPSTRGKVYLDLTRGERTGDPVSVAERSGWTAYGIEDVNAWTTVEMLRLLVGQNVPFDFVRMASYSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>C8V996</accession>
    <name>C8V996_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein-lysine N-methyltransferase EFM6</fullName>
            <ecNumber evidence="1">2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Elongation factor methyltransferase 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">EFM6</name>
        <name evidence="2" type="ORF">ANIA_10539</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that methylates elongation factor 1-alpha.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. METTL21 family. EFM6 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF77815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V996"/>
    <dbReference type="FunCoup" id="C8V996">
        <property type="interactions" value="401"/>
    </dbReference>
    <dbReference type="STRING" id="227321.C8V996"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN10539"/>
    <dbReference type="eggNOG" id="KOG2793">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055721_2_1_1"/>
    <dbReference type="InParanoid" id="C8V996"/>
    <dbReference type="OMA" id="RRADMRF"/>
    <dbReference type="OrthoDB" id="407325at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008276">
        <property type="term" value="F:protein methyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03198">
        <property type="entry name" value="Methyltr_EFM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033684">
        <property type="entry name" value="EFM6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF152">
        <property type="entry name" value="PROTEIN-LYSINE N-METHYLTRANSFERASE EFM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="87"/>
            <end position="89"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF77815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="247" mass="27215" checksum="9CFD2CFBFD1CFBCC" modified="2009-11-03" version="1">MEDIHPGSATSDDPLDISESLVPAREIKQAGQSYVSFDGLLQRPLLLKEDLKEGCGGQLWPAGMVLAKYMLRQHRFSLADKTILELGAGGGLVGLAVASGCEVGPPQIYITDQVPMLPLMKSNIALNNLSRKVKAAVLDWGTTLSDEIPRRPDVILAADCVYFEPAFPLLISTLRDLLGPDSVCYFCFKKRRRADLRFLKLAKRAFQVTEIDDDPEAGTYKRENINLYTIRSKPGTGHHCIDGRDTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>C8V9Z6</accession>
    <name>C8V9Z6_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-phytase</fullName>
            <ecNumber evidence="2">3.1.3.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ANIA_11111</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.8" evidence="2"/>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF78112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_682014.2">
        <property type="nucleotide sequence ID" value="XM_676922.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V9Z6"/>
    <dbReference type="FunCoup" id="C8V9Z6">
        <property type="interactions" value="446"/>
    </dbReference>
    <dbReference type="GeneID" id="2868441"/>
    <dbReference type="KEGG" id="ani:ANIA_11111"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN11111"/>
    <dbReference type="eggNOG" id="KOG1382">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020880_3_1_1"/>
    <dbReference type="InParanoid" id="C8V9Z6"/>
    <dbReference type="OMA" id="RGRSDWC"/>
    <dbReference type="OrthoDB" id="6509975at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016158">
        <property type="term" value="F:inositol hexakisphosphate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1240:FF:000135">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033379">
        <property type="entry name" value="Acid_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963:SF18">
        <property type="entry name" value="ACID PHOSPHATASE PHO11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963">
        <property type="entry name" value="MULTIPLE INOSITOL POLYPHOSPHATE PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00616">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBF78112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="517" mass="57936" checksum="D43BDAB25D855CBF" modified="2009-11-03" version="1">MSGLSSSGSLIGFSIIIVFVSISNFYLDGAFSIIRDYITAPHKGPSTTSPYSSSWNTWFNPSHRTSNYNPSVPESDGWNLYYHLGGYGPWIEKLDGPTQDIKPPAGCHVDQVHMMARHGERYPTKNAGSRHLDLLERIKEANVTLNGSLSFLNNWDYFTSTPEEDFDQLTRTGPYSGMLGAFTTGTRLLTRYHHLLSSQSNFTFWASDCQRVIQTAQYFALGLLGLNWGDIGRAKLEIIPETFDRRADTLTPGDTCLRYLEDTENGHDKGMNMLALFQQSYAPAIAERLLFEQGNSALRALTNMDIFSMQEMCGFETLVRGSSPWCDVFSREDWENFEYARDLVHYYRAGPGNPYAGAMGWLWLNATAGLLQEGPKAGPLFFSFVHDGDIAPFLEALDILKDPKYDPELPATYRADDRVWRTSSVLPMGGRIILERITCSSIDSDRKPDEGTFIRVNINDKIVPLPYCKTGPGLSCPLDEFNGHVGRRNLEVGNFGEVCGLDGDVGRITFLKQQKSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>C8VAB6</accession>
    <name>C8VAB6_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ANIA_11096</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF78251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_681920.2">
        <property type="nucleotide sequence ID" value="XM_676828.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VAB6"/>
    <dbReference type="GeneID" id="2868528"/>
    <dbReference type="KEGG" id="ani:ANIA_11096"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN11096"/>
    <dbReference type="eggNOG" id="KOG1205">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_2_6_1"/>
    <dbReference type="InParanoid" id="C8VAB6"/>
    <dbReference type="OMA" id="LEIAPPW"/>
    <dbReference type="OrthoDB" id="37659at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43669">
        <property type="entry name" value="5-KETO-D-GLUCONATE 5-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43669:SF11">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="189"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBF78251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="209" mass="23309" checksum="B248E56B039592C8" modified="2009-11-03" version="1">MKGRNALSIYPHCSSPILCTNFVSSWAFKKVLIVGATSGIGRAIATRPIEKGIPVVISGRREENLQEFVRQHGSDKVKSKVFDVTKLDKLKIPVFASEVLIENPDIECDFVNSGVQRPFDFSKPDTVDLPMFDQELVTNYASAMALVPMMRCPNYGASKAALHHFILALRTQLRDGLVVEIYPPPVQTELHDTKHQRSQERTSNWDAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>C8VAC4</accession>
    <name>C8VAC4_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Zn(II)2Cys6 transcription factor (Eurofung)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ANIA_08645</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF78267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_681914.2">
        <property type="nucleotide sequence ID" value="XM_676822.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VAC4"/>
    <dbReference type="GeneID" id="2868579"/>
    <dbReference type="KEGG" id="ani:ANIA_08645"/>
    <dbReference type="eggNOG" id="ENOG502SUW5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031656_1_0_1"/>
    <dbReference type="InParanoid" id="C8VAC4"/>
    <dbReference type="OMA" id="NCAFAKV"/>
    <dbReference type="OrthoDB" id="2943660at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045122">
        <property type="term" value="P:aflatoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013700">
        <property type="entry name" value="AflR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050675">
        <property type="entry name" value="OAF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069:SF31">
        <property type="entry name" value="MONODICTYPHENONE CLUSTER TRANSCRIPTION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069">
        <property type="entry name" value="OLEATE-ACTIVATED TRANSCRIPTION FACTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08493">
        <property type="entry name" value="AflR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00755">
        <property type="entry name" value="AFLATOXINBRP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="31"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="94"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="101"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBF78267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="462" mass="49918" checksum="F816CB395E6290BE" modified="2009-11-03" version="1">MTEPFPSSSVCSLSSSRRLPNGQQPRKLRDSCIHCANSKVKCNKEKPICGRCVRRRLPCEYKVSRRTGRTSRSIAQLLGSGSTGRTTETLTISPAIHPANTGGNATSSVLPSNPVTSGPSQTPLLTPITPIPTSEPSPDHCIPQTPDVWRSFLSPSAFNPDVGDLSSLISMPPDVGNLFGSVMGSPLFDTCDIDSLPAQAIGESVSVTEHPLFPTPALSDPKSEDTSETTSNHVKSCLISVLDVFRDVFADTPTPCKKADRQQSSSRAPTIESVVSDNREAIDTLSAVMDCPCSHDGYILSIVSLAVLKVMGRYIAAARGQIPATEDTRGWGQEVSMHSDRSRQFLPFDEQLPGSPGPVGSYSIEGRNQNRMAAQLVLSELHRVQRLVNVLASRLENVRLRSCLSPASTFGPNSTDSIIENPLLAARRILPLSGSTFSKMEDDLRKRLRAVSSETIEILRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>C8VAN8</accession>
    <name>C8VAN8_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pyridoxamine phosphate oxidase, putative (AFU_orthologue AFUA_3G06670)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_04780</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF76796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_662384.2">
        <property type="nucleotide sequence ID" value="XM_657292.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VAN8"/>
    <dbReference type="FunCoup" id="C8VAN8">
        <property type="interactions" value="37"/>
    </dbReference>
    <dbReference type="STRING" id="227321.C8VAN8"/>
    <dbReference type="GeneID" id="2872580"/>
    <dbReference type="KEGG" id="ani:ANIA_04780"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN4780"/>
    <dbReference type="eggNOG" id="ENOG502S6QN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078856_0_0_1"/>
    <dbReference type="InParanoid" id="C8VAN8"/>
    <dbReference type="OMA" id="HPTIIMT"/>
    <dbReference type="OrthoDB" id="5300823at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052841">
        <property type="entry name" value="PMP_oxidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28040">
        <property type="entry name" value="PYRIDOXAMINE 5'-PHOSPHATE OXIDASE YLR456W HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28040:SF1">
        <property type="entry name" value="PYRIDOXAMINE 5'-PHOSPHATE OXIDASE YLR456W HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="PNPOx_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyridoxamine 5'-phosphate oxidase N-terminal" evidence="2">
        <location>
            <begin position="43"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF76796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="258" mass="28550" checksum="F03724B30669A8CE" modified="2009-11-03" version="1">MPFVHLPPSRNNARPETMSDSLNPPLSYEASATTTHRHVATTLPPEVSSCLKNSRFLHLATCDGLTPHISLMSYTYLPSTPFDPYPTIIMTTNSSSRKTTHLQTNPRVSLLVHDWVSHRPPTRASNPGNTRDGSPPPAATRSSLASLLLNLNTSALSSISTTITGEARFLQPNSEEETWCKERHLENNTFEEEMSTFGQAQQPGQRRPSLSIDDDVRVITIRVREGRLADWKGGVRDWLVVQEGEEGPDETTPNGVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>C8VBR5</accession>
    <name>C8VBR5_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ubiquitin-conjugating enzyme E2 Z</fullName>
            <ecNumber evidence="3">2.3.2.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">E2 ubiquitin-conjugating enzyme Z</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Ubiquitin carrier protein Z</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Ubiquitin-protein ligase Z</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">ANIA_07577</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="17">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="3"/>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF79663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467984.1">
        <property type="nucleotide sequence ID" value="XM_050612023.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VBR5"/>
    <dbReference type="STRING" id="227321.C8VBR5"/>
    <dbReference type="GeneID" id="2869515"/>
    <dbReference type="KEGG" id="ani:ANIA_07577"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN7577"/>
    <dbReference type="eggNOG" id="KOG0895">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037142_0_0_1"/>
    <dbReference type="InParanoid" id="C8VBR5"/>
    <dbReference type="OMA" id="SKLFWGS"/>
    <dbReference type="OrthoDB" id="1926878at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23809">
        <property type="entry name" value="UBCc_UBE2Z"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00195">
        <property type="entry name" value="UBCc_UEV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000103">
        <property type="entry name" value="Ubiquitin conjugating enzyme, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46116">
        <property type="entry name" value="(E3-INDEPENDENT) E2 UBIQUITIN-CONJUGATING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46116:SF26">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2 Z"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="15">
        <location>
            <begin position="4"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="UBC core" evidence="15">
        <location>
            <begin position="293"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00041798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00042316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00042401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CBF79663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="449" mass="51746" checksum="9B76A627E91181FF" modified="2009-11-03" version="1">MSDQAIIRITREIKQIENSADLSIAVDYDEKDIRNVRAVILGPPETPYQFGFFEFSIKFGKDYPARAPSVRALTTNSGVCRFSPNLYAGGKVCLSILGTWTGQPGEQWSSAQGLESVLISIQSLMSSNPYENEPGYEHAKSQTDEENMAHYKAKIRHETIRIAVLQPLESAMGISLDATSKSPGYEKYLSEADDSSEDENHTSTNAFIDLRKRRFLWYYDSYVQLIQSESAKETITPKLPFHRMPFESHGNTMDGHFDYPELQQRLMYLKGKIMDETKNWQAQGLEAKKNELGIAVNLQRQYEQIVETLKNHKNYSIDLTLVNGNPFLWKLTYFGRPTTPLEGGIIKIRIHLSPRFPEEQPRIFVETRLFHVRVSKEGVLCYFPRRIEEMRQHVEAIVAVLEEQEPPYDPRTTVNIEAAKLFWGSPEDRKKYKRTLRRDVERSVEDAFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2025-10-08" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>C8VCG4</accession>
    <name>C8VCG4_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ANIA_10933</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF78495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_680650.2">
        <property type="nucleotide sequence ID" value="XM_675558.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VCG4"/>
    <dbReference type="GeneID" id="2869833"/>
    <dbReference type="KEGG" id="ani:ANIA_10933"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN10933"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_0_1"/>
    <dbReference type="InParanoid" id="C8VCG4"/>
    <dbReference type="OMA" id="VTSMVMM"/>
    <dbReference type="OrthoDB" id="1393670at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:001190">
        <property type="entry name" value="Short-chain dehydrogenase/reductase SDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24321">
        <property type="entry name" value="DEHYDROGENASES, SHORT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24321:SF15">
        <property type="entry name" value="OXIDOREDUCTASE UCPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBF78495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="287" mass="30854" checksum="8C64B6638BDD9526" modified="2009-11-03" version="1">MTSPRAFDFTDEVAIVTGAGSRLAGEIGNGRATAILLARQGAKVALVDYNVDWAQETKRMIDLDGGQSIVIQADVTDEESCKKAVAQTIGAFGTVNILVNIVGVGGAMGDATRLDLAAWDRDFRINVTSMVLMSRYVIPEMRKNGRGAIVNMSSVSGLLGGNPSLLYPTTKGAIIQMTRAMAAQHGPENIRVNCVCPGMVFTPMVRGRGMTDEMRQARINQNLLKQEGTGWDVGYAILFLCSKEAKWITGLIMPVDGGCSLSTFCKDIMVSKSSAMKQIDMSDIFGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>C8VDN2</accession>
    <name>C8VDN2_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Pyruvate carboxylase, putative (AFU_orthologue AFUA_5G07570)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ANIA_11009</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF80060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468041.1">
        <property type="nucleotide sequence ID" value="XM_050612084.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VDN2"/>
    <dbReference type="STRING" id="227321.C8VDN2"/>
    <dbReference type="GeneID" id="2869687"/>
    <dbReference type="KEGG" id="ani:ANIA_11009"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN11009"/>
    <dbReference type="eggNOG" id="KOG0369">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000395_3_2_1"/>
    <dbReference type="InParanoid" id="C8VDN2"/>
    <dbReference type="OMA" id="KGDAWSI"/>
    <dbReference type="OrthoDB" id="196847at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06850">
        <property type="entry name" value="biotinyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000003">
        <property type="entry name" value="acetyl-CoA carboxylase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45007">
        <property type="entry name" value="CARBOXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G07570)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45007:SF1">
        <property type="entry name" value="CARBOXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G07570)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0092">Biotin</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="9">
        <location>
            <begin position="6"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="8">
        <location>
            <begin position="123"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="7">
        <location>
            <begin position="566"/>
            <end position="646"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBF80060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="653" mass="72244" checksum="368BE11171A445C6" modified="2009-11-03" version="1">MLVARPIQRILVANRGEIAVRILQATREACPSIKTYALYTDNDRTHCDIGRPHHALHITPDGYLDIELLVRLVQQHAIDAIHPGYGFLSESAEFARRMQDLGVIVIGPGWEALDRTGDKLRAKQLAVENNVPVLPSLEYDMATPRATGLGKIKSFAHNVGYPVMIKAVDGGGGRGIRLVHRDDDLGHAVRASAAESPSQTVFVEKAAIDGFHHIEIQIVGDGKDVQHLWERDCSVQRRFQKIVEIAPSLIRDRNQELVSRIADAAVRMMKAIRYRSLGTVEFLVNEQLNEFYFLEINPRIQVEHTITEAITGVDLVQTQLLIAQGYFLAQLGLDTCPKARGHCIQLRLCSEDPRANFSLSVGKVMDFSVPTGNGVRLDTHIDVTGLSPVVVGAQFDNLLAKIIVSGSLTWQATVLKARRVLADTRISGVKTNLDLLRGIIGQESFLNGSADTQWLERHLDQVVQEGVSTSGSLQAAAPSSHQTGAPSMPQSNLLFRPGDAWSITLEPLSSQRETQQQHHIQLTRVLQNDFPASISAEVQYSTPSSSTAYRVKLETTNTTASALVSSHRRGDPRNPRHIVLPLSGKLIEVLVLPGDIIEENQVVAFVKQMKMELEVRSPRAGRAQWVYEMEEEEEDVAEGILLVELEEELRGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>C8VF25</accession>
    <name>C8VF25_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_05156</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF80977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468153.1">
        <property type="nucleotide sequence ID" value="XM_050612208.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VF25"/>
    <dbReference type="STRING" id="227321.C8VF25"/>
    <dbReference type="GeneID" id="2871446"/>
    <dbReference type="KEGG" id="ani:ANIA_05156"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN5156"/>
    <dbReference type="eggNOG" id="KOG1674">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023749_3_0_1"/>
    <dbReference type="InParanoid" id="C8VF25"/>
    <dbReference type="OMA" id="HSHYEPT"/>
    <dbReference type="OrthoDB" id="337735at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048315">
        <property type="term" value="P:conidium formation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030643">
        <property type="term" value="P:intracellular phosphate ion homeostasis"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0075308">
        <property type="term" value="P:negative regulation of conidium formation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000909">
        <property type="term" value="P:sporocarp development involved in sexual reproduction"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="CDD" id="cd20558">
        <property type="entry name" value="CYCLIN_ScPCL7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF117">
        <property type="entry name" value="PHO85 CYCLIN PHO80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08613">
        <property type="entry name" value="Cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF80977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="390" mass="41698" checksum="10315E91F338BC6E" modified="2009-11-03" version="1">MLVSSPSPSALRPAPSSPAATQLHPPHSPCSTSFTRRLSSTSAALAYQAQQYDSAADRSVVPGSPFTPRSSRVAVEELRSALKRHSVSSPPSRPSGDPACGRMSAGQTSLGGGISTSASAAASFAAGPSSNAALPETSNQSTANTSSVPGPAPTVPPAFAAPQNTQPPPMPAPTTTAGSNKRNSQSDSTRGVEPAGPGSLSLEGSQSKRLRPANPAVKYLPVRYEFADPRDLVVLISSMLMELIRYNDKIPLNQGRLTRFHSRTPPRISVHDYLQRLTTHATLSPPILLSMVYYIDRLCALYPAFTVSSLTIHRFLITSATVASKGLSDSFWTNKTYARVGGISMAELALLELEFLFRVEWRIVPQPEVLNDYYQSLVERCDGYEIQSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>C8VFA4</accession>
    <name>C8VFA4_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ANIA_11471</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF81122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468167.1">
        <property type="nucleotide sequence ID" value="XM_050612224.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VFA4"/>
    <dbReference type="GeneID" id="74897048"/>
    <dbReference type="KEGG" id="ani:ANIA_11471"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN11471"/>
    <dbReference type="HOGENOM" id="CLU_3106324_0_0_1"/>
    <dbReference type="InParanoid" id="C8VFA4"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF81122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="51" mass="5600" checksum="D3D10D66BB0CC462" modified="2009-11-03" version="1">MFRKGKALRSPAMGGYCSLVDASTYPSSSDPSSLSLKLLKAFRRLASMMQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>C8VFG6</accession>
    <name>C8VFG6_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PRA1 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ANIA_10724</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Membrane</location>
            <topology evidence="1 5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PRA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF81237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_663373.2">
        <property type="nucleotide sequence ID" value="XM_658281.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VFG6"/>
    <dbReference type="FunCoup" id="C8VFG6">
        <property type="interactions" value="261"/>
    </dbReference>
    <dbReference type="STRING" id="227321.C8VFG6"/>
    <dbReference type="GeneID" id="2872062"/>
    <dbReference type="KEGG" id="ani:ANIA_10724"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN10724"/>
    <dbReference type="eggNOG" id="KOG3142">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103851_1_1_1"/>
    <dbReference type="InParanoid" id="C8VFG6"/>
    <dbReference type="OMA" id="PWTVFFN"/>
    <dbReference type="OrthoDB" id="63113at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004895">
        <property type="entry name" value="Prenylated_rab_accept_PRA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19317">
        <property type="entry name" value="PRENYLATED RAB ACCEPTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19317:SF0">
        <property type="entry name" value="PRENYLATED RAB ACCEPTOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03208">
        <property type="entry name" value="PRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="70"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="121"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="143"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBF81237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="174" mass="19131" checksum="0C247BF3B98AB2AC" modified="2009-11-03" version="1">MSSIQIPIDAITSRFGDRFNSLRSQSLGSRFANLRPISEFLDFKRLSKPANFGEAQSRVNYNLSYFSSNYAAIFVLLSIYSLLTNPLLLFVIFLVSGGLWGIGKLGGRDLDLGFARFNTSQLYTGLLIVAVPLGFWASPIATFLWLIGATGVTVFGHAAFMDKPIENAFSEEAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>C8VGR8</accession>
    <name>C8VGR8_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ANIA_11476</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF82043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468276.1">
        <property type="nucleotide sequence ID" value="XM_050612342.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VGR8"/>
    <dbReference type="GeneID" id="74897053"/>
    <dbReference type="KEGG" id="ani:ANIA_11476"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN11476"/>
    <dbReference type="HOGENOM" id="CLU_205444_0_0_1"/>
    <dbReference type="InParanoid" id="C8VGR8"/>
    <dbReference type="OMA" id="MGICESG"/>
    <dbReference type="OrthoDB" id="4233515at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009101">
        <property type="entry name" value="Gurmarin/antifun_pep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024206">
        <property type="entry name" value="Gurmarin/antimicrobial_peptd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11410">
        <property type="entry name" value="Antifungal_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57048">
        <property type="entry name" value="Gurmarin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0929">Antimicrobial</keyword>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0960">Knottin</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002993134" evidence="4">
        <location>
            <begin position="18"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBF82043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="54" mass="5483" checksum="75174FDCDA5B93CF" modified="2009-11-03" version="1">MNFSWLATLALIGTAMAAGKTLPAGAPCTKDGKMGVCESGVCIQDVNADKGHCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>C8VH91</accession>
    <name>C8VH91_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed RNA polymerases I, II, and III subunit RPABC5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ANIA_11183</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF82635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468359.1">
        <property type="nucleotide sequence ID" value="XM_050612435.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VH91"/>
    <dbReference type="FunCoup" id="C8VH91">
        <property type="interactions" value="475"/>
    </dbReference>
    <dbReference type="STRING" id="227321.C8VH91"/>
    <dbReference type="GeneID" id="74896830"/>
    <dbReference type="KEGG" id="ani:ANIA_11183"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN11183"/>
    <dbReference type="eggNOG" id="KOG3497">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_143122_2_1_1"/>
    <dbReference type="InParanoid" id="C8VH91"/>
    <dbReference type="OMA" id="YCCRRMF"/>
    <dbReference type="OrthoDB" id="10258858at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006360">
        <property type="term" value="P:transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000024">
        <property type="entry name" value="DNA-directed RNA polymerases I, II, and III subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00250">
        <property type="entry name" value="RNApol_arch_Rpo10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023580">
        <property type="entry name" value="RNA_pol_su_RPB10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020789">
        <property type="entry name" value="RNA_pol_suN_Zn-BS"/>
    </dbReference>
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        <property type="entry name" value="RPABC5/Rpb10"/>
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        <property type="entry name" value="PRK04016.1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC5"/>
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        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC5 FAMILY MEMBER"/>
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        <property type="entry name" value="RNA_pol_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RNA_pol_N/8_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RNA polymerase subunit RPB10"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="RNA_POL_N_8KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBF82635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="74" mass="8619" checksum="7C2D523BC342E62D" modified="2009-11-03" version="1">MIIPVRCFSCGKVVGDLWERYLQLLDDGIPDGDAMDQLGCKRYCCRRMVMTHVDLIEKLLRYNPTERDRAKAQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>C8VH93</accession>
    <name>C8VH93_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_11640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF82638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468360.1">
        <property type="nucleotide sequence ID" value="XM_050612436.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VH93"/>
    <dbReference type="GeneID" id="74897193"/>
    <dbReference type="KEGG" id="ani:ANIA_11640"/>
    <dbReference type="HOGENOM" id="CLU_3399386_0_0_1"/>
    <dbReference type="InParanoid" id="C8VH93"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF82638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="31" mass="3411" checksum="DBB5E7A1BE37A7AF" modified="2009-11-03" version="1">MIPANLTCSTQPTKPDPTRPNLPRNGLVYNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>C8VHI8</accession>
    <name>C8VHI8_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Nicotinate-nucleotide pyrophosphorylase [carboxylating]</fullName>
            <ecNumber evidence="6">2.4.2.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Quinolinate phosphoribosyltransferase [decarboxylating]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ANIA_03431</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in the catabolism of quinolinic acid (QA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 6">
            <text>nicotinate beta-D-ribonucleotide + CO2 + diphosphate = quinolinate + 5-phospho-alpha-D-ribose 1-diphosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:12733"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:29959"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from quinolinate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Hexamer formed by 3 homodimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the NadC/ModD family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.19" evidence="6"/>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF82722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468379.1">
        <property type="nucleotide sequence ID" value="XM_050612457.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VHI8"/>
    <dbReference type="FunCoup" id="C8VHI8">
        <property type="interactions" value="223"/>
    </dbReference>
    <dbReference type="STRING" id="227321.C8VHI8"/>
    <dbReference type="GeneID" id="2873862"/>
    <dbReference type="KEGG" id="ani:ANIA_03431"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN3431"/>
    <dbReference type="eggNOG" id="KOG3008">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039622_1_0_1"/>
    <dbReference type="InParanoid" id="C8VHI8"/>
    <dbReference type="OMA" id="DIVMCDN"/>
    <dbReference type="OrthoDB" id="10067394at2759"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00331"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004514">
        <property type="term" value="F:nicotinate-nucleotide diphosphorylase (carboxylating) activity"/>
        <property type="evidence" value="ECO:0000318"/>
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    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD+ biosynthetic process"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0034213">
        <property type="term" value="P:quinolinate catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd01572">
        <property type="entry name" value="QPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1170.20:FF:000003">
        <property type="entry name" value="Nicotinate-nucleotide pyrophosphorylase [carboxylating]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000030">
        <property type="entry name" value="Nicotinate-nucleotide pyrophosphorylase, carboxylating"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.20">
        <property type="entry name" value="Quinolinate phosphoribosyl transferase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004393">
        <property type="entry name" value="NadC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027277">
        <property type="entry name" value="NadC/ModD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036068">
        <property type="entry name" value="Nicotinate_pribotase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037128">
        <property type="entry name" value="Quinolinate_PRibosylTase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002638">
        <property type="entry name" value="Quinolinate_PRibosylTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022412">
        <property type="entry name" value="Quinolinate_PRibosylTrfase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00078">
        <property type="entry name" value="nadC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32179">
        <property type="entry name" value="NICOTINATE-NUCLEOTIDE PYROPHOSPHORYLASE [CARBOXYLATING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32179:SF3">
        <property type="entry name" value="NICOTINATE-NUCLEOTIDE PYROPHOSPHORYLASE [CARBOXYLATING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01729">
        <property type="entry name" value="QRPTase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02749">
        <property type="entry name" value="QRPTase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006250">
        <property type="entry name" value="NadC_ModD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51690">
        <property type="entry name" value="Nicotinate/Quinolinate PRTase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54675">
        <property type="entry name" value="Nicotinate/Quinolinate PRTase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3 6" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Quinolinate phosphoribosyl transferase N-terminal" evidence="8">
        <location>
            <begin position="39"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="Quinolinate phosphoribosyl transferase C-terminal" evidence="7">
        <location>
            <begin position="117"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR006250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBF82722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="319" mass="34013" checksum="93B0C36BA569B4C4" modified="2009-11-03" version="1">MASAHGDLRHLLPATYKRLISDWLEEDCPSFDYGGFVVGESEGEAKLLGKSEGIIAGVPFFDEVFSQLGCSVEWHHHEGSSLPANQKTHVATVRGPIRKILLGERVALNILARCSGIATKTSSLLQILRSHGWKGTLAGTRKTTPGFRVVEKYGILVGGADPHRHDLSSMTMLKDNHVWACANNASSSTATTAANGEQDIAAAIPKAVQAAKAVGGFATKVEVEVRSLDEANAAIEAGADVVMLDNFTSEGVRQAAKQLKEEWTAKGKSRGSFLIEVSGGLNEVNALQYVCDDVDIFSTSSIHQGVGIVDFSLKVSLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>C8VHR9</accession>
    <name>C8VHR9_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_11391</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF82872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468397.1">
        <property type="nucleotide sequence ID" value="XM_050612479.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VHR9"/>
    <dbReference type="GeneID" id="74896985"/>
    <dbReference type="KEGG" id="ani:ANIA_11391"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN11391"/>
    <dbReference type="HOGENOM" id="CLU_2638062_0_0_1"/>
    <dbReference type="InParanoid" id="C8VHR9"/>
    <dbReference type="OrthoDB" id="2364732at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF82872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="77" mass="8674" checksum="FC35D29F53777EF5" modified="2009-11-03" version="1">MGCGSNPVLQKERKVTLGPPDLQDLTPAILREFSSSTETLSTRQDDIEWCTARTIEAQDQDKFYRCFNKRAGRGVPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>C8VHX6</accession>
    <name>C8VHX6_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ANIA_10397</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF82956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468407.1">
        <property type="nucleotide sequence ID" value="XM_050612492.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VHX6"/>
    <dbReference type="GeneID" id="74896383"/>
    <dbReference type="KEGG" id="ani:ANIA_10397"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN10397"/>
    <dbReference type="eggNOG" id="KOG0504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_906228_0_0_1"/>
    <dbReference type="InParanoid" id="C8VHX6"/>
    <dbReference type="OMA" id="CMENALI"/>
    <dbReference type="OrthoDB" id="341259at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
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    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
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    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
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    <dbReference type="PANTHER" id="PTHR24171:SF9">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
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    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
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    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
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        <property type="entry name" value="Ankyrin repeat"/>
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        <property type="entry name" value="ANK_REP_REGION"/>
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    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
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        <location>
            <begin position="19"/>
            <end position="51"/>
        </location>
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    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="52"/>
            <end position="84"/>
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    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="85"/>
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    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="115"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="148"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBF82956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="307" mass="33967" checksum="2BA8112BE4D83529" modified="2009-11-03" version="1">MLVNQPNWDYSLVNKKSKERPTPLHEAAKNGHEKIISILLDRGAKVDERDEKRRVPLHEAAAGGHTGIVSLLLHKGAKVDEMDEAGRVPLHEAAAGGRNTVIEILLAGINIKDKEGRTPLHHAAKEGHLPSVSVLLSHGAWADVPDNDERTPLYLAAIHGRLEAVQKLLSEDADFRKTDIEGRGISAVLKEISDENFSEEVKEQLSQIKKLFEGLSRSPELYTESICGNEAVDSQFSCAIIKFASGIFQRQRKNSEPSIDKVISGQEEIFGPRMEENDVRFRWLHLPVNNVSSTGSHDTDITNVSES</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>C8VJ79</accession>
    <name>C8VJ79_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">26S proteasome regulatory subunit 6B homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">ANIA_02904</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF83778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468509.1">
        <property type="nucleotide sequence ID" value="XM_050612601.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VJ79"/>
    <dbReference type="FunCoup" id="C8VJ79">
        <property type="interactions" value="1249"/>
    </dbReference>
    <dbReference type="STRING" id="227321.C8VJ79"/>
    <dbReference type="GeneID" id="2873987"/>
    <dbReference type="KEGG" id="ani:ANIA_02904"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN2904"/>
    <dbReference type="eggNOG" id="KOG0727">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000688_2_0_1"/>
    <dbReference type="InParanoid" id="C8VJ79"/>
    <dbReference type="OMA" id="QDIGGMD"/>
    <dbReference type="OrthoDB" id="10255768at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:ATP hydrolysis activity"/>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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        <property type="term" value="P:positive regulation of RNA polymerase II transcription preinitiation complex assembly"/>
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        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0070682">
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        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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    <dbReference type="CDD" id="cd19502">
        <property type="entry name" value="RecA-like_PAN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="26S protease regulatory subunit 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000049">
        <property type="entry name" value="26S protease regulatory subunit 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000033">
        <property type="entry name" value="26S protease regulatory subunit 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 14" id="KW-0647">Proteasome</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="13">
        <location>
            <begin position="199"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="59"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00068703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CBF83778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="422" mass="47119" checksum="563ABD5A00BE6409" modified="2009-11-03" version="1">MGDIAVENPASVLSSYTKAAPLDTIPNIDSLEGTGADDGDEYATLKKLQRHLEYIKLQEEYIKDEQRSLKRELVRAQEEIKRIQSVPLVIGQFMEAIDQNTGIVQSSTGSNYVVRILSTLDREKLKPSSSVALHRHSNALVDILPPEADSSIAMLGENEKPDVTYADVGGLDMQKQEIREAVELPLTHFDLYKQIGIDPPRGVLLYGPPGTGKTMLVKAVANSTTASFIRVNGSEFVQKYLGEGPRMVRDVFRMARENSPAIIFIDEIDAIATKRFDAQTGADREVQRILLELLNQMDGFEQTSNVKVIMATNRADTLDPALLRPGRLDRKIEFPSLRDRRERRLIFSTIASKMSLSPEVDLDSLIVRNEPLSGAVIAAIMQEAGLRAVRKNRYNIIQSDLEDAYSAQVKTGQEADRLEFYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>C8VKF0</accession>
    <name>C8VKF0_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_11359</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF84241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468572.1">
        <property type="nucleotide sequence ID" value="XM_050612679.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VKF0"/>
    <dbReference type="GeneID" id="74896958"/>
    <dbReference type="KEGG" id="ani:ANIA_11359"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN11359"/>
    <dbReference type="HOGENOM" id="CLU_2440838_0_0_1"/>
    <dbReference type="InParanoid" id="C8VKF0"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF84241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="90" mass="10641" checksum="3627FDF7EF9BBB2F" modified="2009-11-03" version="1">MPIKSLTRHQKQPWKASTAYYINNFRYPWDNLKSPCYYQRGDFNMTFTGLVYQLPLFEPPNSTSQRARIDRADEPESTEPTSQYCRAVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>C8VLU6</accession>
    <name>C8VLU6_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cell cycle checkpoint protein Rad17, putative (AFU_orthologue AFUA_8G02820)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ANIA_08876</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the rad17/RAD24 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF84756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_682145.2">
        <property type="nucleotide sequence ID" value="XM_677053.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VLU6"/>
    <dbReference type="FunCoup" id="C8VLU6">
        <property type="interactions" value="137"/>
    </dbReference>
    <dbReference type="STRING" id="227321.C8VLU6"/>
    <dbReference type="GeneID" id="2868164"/>
    <dbReference type="KEGG" id="ani:ANIA_08876"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN8876"/>
    <dbReference type="eggNOG" id="KOG1970">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006397_0_0_1"/>
    <dbReference type="InParanoid" id="C8VLU6"/>
    <dbReference type="OMA" id="YNKREDP"/>
    <dbReference type="OrthoDB" id="10265971at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002611">
        <property type="entry name" value="Cell cycle checkpoint protein Rad17, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004582">
        <property type="entry name" value="Checkpoint_prot_Rad17_Rad24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057927">
        <property type="entry name" value="RAD24-like_helical"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12172">
        <property type="entry name" value="CELL CYCLE CHECKPOINT PROTEIN RAD17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12172:SF0">
        <property type="entry name" value="CELL CYCLE CHECKPOINT PROTEIN RAD17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03215">
        <property type="entry name" value="Rad17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25812">
        <property type="entry name" value="RAD24_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Checkpoint protein RAD24-like helical bundle" evidence="9">
        <location>
            <begin position="435"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="18"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="723"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="741"/>
            <end position="750"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF25812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBF84756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="766" mass="85230" checksum="A0E4CD003BD3D73B" modified="2009-11-03" version="1">MRNHKTQQLSDTTVCGLLQSASEPNYSHRRWPNSQMPGSAGTADVDDNEDSIEDDYDSYDDLFTQHFTDEKLSHLDGIKVAPRPQNRAISPIGNAKDQTAKNAKHFFWKSVSPSNNELPNPTPSEKGALPWAQRYAPLNLDELAVHKRKVGDVERWLSDALEGKTRKNLLILRGPAGSGKTTTISLLSKKLRFDVLEWKTPSTVTYSSKDYVSFGAQFDGFLSRSHIFGSLTLDGHHSSQVPLNNDHASQRRVILIEEFPTMAARNTTVLASFRLSILRYLSLNGPHGGNTYGREVRVPPIVMVVSETFSSTESSFNNLTTHQLLGRELYNHPDTTIIEFNSIAPTFMHKALNLVLKKSSCQPCGNQTLTQSIIENISKIGDIRNAIASLEFICLGNGNKGYWSDPTVKTRRTARTRMKNTAVGSEMREEIAQREASLGLFHAVGKIIYNKRSDASDAEHVQLPSPPDHLRDHDRPTVSMVHVNELLDETGTDIQLFIGTLHENYVPSCNGSSFTECLEGCIGFLSDSDMLCYDRKDRSKFQAGLGIGTVKIETGGVDVLRQEEISYQVAARGLLFSLPYPVRRQLSYARNIKQAGDSHKVFFPPVIRLVRQLQEISNQIDSWKDALLSSTVRPTAVPMKDHTTREFISGKGKSLQGNRDEESPSLVAMLSRSDLILHQLPYLTKIVGKGTMSKNLQQSTGFGAGGSDFTSQHDEDYDFEPSFCEAPGPKSRLEKRIGLSEPQTTLSSQTTDERLVLSDDDIIDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>C8VP08</accession>
    <name>C8VP08_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ubiquitin-protein ligase (Asi3), putative (AFU_orthologue AFUA_6G10590)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_02442</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF86861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_660046.2">
        <property type="nucleotide sequence ID" value="XM_654954.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VP08"/>
    <dbReference type="GeneID" id="2874703"/>
    <dbReference type="KEGG" id="ani:ANIA_02442"/>
    <dbReference type="eggNOG" id="ENOG502S2K4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006057_0_0_1"/>
    <dbReference type="InParanoid" id="C8VP08"/>
    <dbReference type="OMA" id="ERMNVTP"/>
    <dbReference type="OrthoDB" id="66726at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22696">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22696:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="323"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="355"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="392"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="544"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="722"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="815"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF86861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="928" mass="102948" checksum="1ED46489D090E1DD" modified="2009-11-03" version="1">MSSSTGTGIPSTAMNTSAHSPSVSSVNLSSTESDYVLRLFRGLRRAESYAFYLVPERLLRITGYRELQAYVWNTFGVGREMHAIAAATEAAGEAAREAAVEAAAQPDTGIHFTDLLQGAIKITIYASTRRHLHLDWMRRLALRIIPILLFVSQIHSLLRAIKCQTSPDYPELRYGTPGKSLLLDHAGQGGFLYSLSSTLLPWETDQHSCNALGMNRVGSDIPNGTFRLLWPVFLRICLSHFVETLSSSLQGRPVVAEGGMSIFEHSLSFAEAESTISQSLGLGPFSSPKPSTGGDGGGESSRSSLHMLTKSQILDRMNVTPELLLIALISCCHCLSSNVLDVLGKQSRYRLVNTTFWGLCFMAAMTWGLVSGSPPNSDGLSVRFPTVCVVGFIPHLMILCGIIVCAGIYSIALVITAFSLPSDTPQQLTLRQRFQLAHENMQGSNQVGSVRLNPHEDFYSALLRIGYTALTAASEAVFLNEGRSVVARNMTWLEEDRLAEIEQSRRVRSVQQASGTLPADFPFENRELVAFEVQEAASEWESGYGKEKKFQRPKNKPRTSRYQTNPGGVGAFRGLVRCYQGISFFRAIFYLMFRWVTVASDKALSRVGITARPQWVKAILRSKAAQDNSGKTEPESLDFWILTDEGELELPENHEFDVEKEMRKRERLNAGDWSPSDEQRLDEKLYNWWKAGGSWGNEDHTSDYELSENDWDDTTSVVSTVTTDSEWEDESDGRRTPTQTNPFPNEYYRESTPTPESLMDVSSIARLLDPPDEATRQEARILAAHLNAGREGRVLTRRQYQAQIERQRAQVLLGPHRSRLAAGSRDGNQKPSAQEESEILEKLILDKRSATLASAANTEQTWETGASGLGSSGPPCVVCQTNSRSIIVWPCRCLCICEDCRVSLAMNNFGSCVTCRQEVGGFVRLWVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>C8VP29</accession>
    <name>C8VP29_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cellular morphogenesis protein (Bud22), putative (AFU_orthologue AFUA_6G08800)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ANIA_10232</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF85449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="GeneID" id="74896283"/>
    <dbReference type="KEGG" id="ani:ANIA_10232"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN10232"/>
    <dbReference type="eggNOG" id="ENOG502S6Z4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029647_0_0_1"/>
    <dbReference type="InParanoid" id="C8VP29"/>
    <dbReference type="OMA" id="ALWEKKF"/>
    <dbReference type="OrthoDB" id="3364872at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0000318"/>
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        <property type="term" value="P:maturation of SSU-rRNA"/>
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        <property type="entry name" value="Bud22/SRFB1"/>
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    <dbReference type="InterPro" id="IPR015158">
        <property type="entry name" value="Bud22_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23325">
        <property type="entry name" value="SERUM RESPONSE FACTOR-BINDING"/>
        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR23325:SF1">
        <property type="entry name" value="SERUM RESPONSE FACTOR-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09073">
        <property type="entry name" value="BUD22"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bud22" evidence="3">
        <location>
            <begin position="45"/>
            <end position="494"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="2">
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            <begin position="1"/>
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    <feature type="region of interest" description="Disordered" evidence="2">
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            <begin position="194"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="2">
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            <begin position="9"/>
            <end position="18"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
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            <begin position="237"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
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            <begin position="261"/>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
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            <begin position="271"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="2">
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            <begin position="295"/>
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            <begin position="320"/>
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            <begin position="397"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="460"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBF85449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="494" mass="54188" checksum="50756E5526929F6E" modified="2009-11-03" version="1">MPKRKLSDLTDTNDTAQPQKPKLSEKEYQHLKLQTARLKQKFEFGVTSLSRALKTARGFERQKLGRRQKVAKGGPGTEIAVAHAKKAKSKPKSNVSPEETLRRIEGEIQVLKSLDPTTTAEKYLFKQLAKTKRIAESPVFYRFKQSKEKKIKLEGPKSTEEANVTARLFKSNPVQNVLPGIMEGLRGLFGLEGAGAKGKKDERDGGKRKAGEQAGGRKDVSGDESVSGSEDEDEADARDARGLERDIDMKDAESGDDEEDYSHFDARLASDSEDSNDDLLSEDNDNTGSRHARRSSMSISLSPSRSPSPSQSPPPKKPKSTSASKTPATSTTFLPSLMMGGYWSGSESEPEELEEAPKRKNRMGQQARRALWEKKYGAAANHIKAEQQKGQKGKGKGGRDAGWDLRKGATGDGDRDRDRGRKKFGTGSNAMAMSGKDRFGSGTSTAKERTTQGAKSKKTKPQDDKPLHPSWEAARKAKEQKATASFQGKKVVFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>C8VPU4</accession>
    <name>C8VPU4_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphoglycerate mutase family protein, putative (AFU_orthologue AFUA_7G06750)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_11348</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF87096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468926.1">
        <property type="nucleotide sequence ID" value="XM_050613085.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VPU4"/>
    <dbReference type="STRING" id="227321.C8VPU4"/>
    <dbReference type="GeneID" id="74896949"/>
    <dbReference type="KEGG" id="ani:ANIA_11348"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN11348"/>
    <dbReference type="eggNOG" id="ENOG502RZAI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2372792_0_0_1"/>
    <dbReference type="InParanoid" id="C8VPU4"/>
    <dbReference type="OrthoDB" id="425925at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF87096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="95" mass="10555" checksum="560DB7E89BA83234" modified="2009-11-03" version="1">MAMTPKDHGKRNRPYLTVLPLAEDLGLEVDISCDRDDPECVKDGVDNFDGDGNVLICWEHDALTDIIEELGDDDAPEYPEEDRPLSVDAPDEIGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>C8VQ30</accession>
    <name>C8VQ30_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">2-isopropylmalate synthase</fullName>
            <ecNumber evidence="7">2.3.3.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">ANIA_00840</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="17">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3-methyl-2-oxobutanoate + acetyl-CoA + H2O = (2S)-2-isopropylmalate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21524"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.13" evidence="7"/>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF88679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050469120.1">
        <property type="nucleotide sequence ID" value="XM_050613292.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VQ30"/>
    <dbReference type="FunCoup" id="C8VQ30">
        <property type="interactions" value="184"/>
    </dbReference>
    <dbReference type="STRING" id="227321.C8VQ30"/>
    <dbReference type="GeneID" id="2876618"/>
    <dbReference type="KEGG" id="ani:ANIA_00840"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN0840"/>
    <dbReference type="eggNOG" id="KOG2367">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004588_3_0_1"/>
    <dbReference type="InParanoid" id="C8VQ30"/>
    <dbReference type="OMA" id="WPDKVID"/>
    <dbReference type="OrthoDB" id="418791at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003852">
        <property type="term" value="F:2-isopropylmalate synthase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd07942">
        <property type="entry name" value="DRE_TIM_LeuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000045">
        <property type="entry name" value="2-isopropylmalate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.270:FF:000002">
        <property type="entry name" value="2-isopropylmalate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00572">
        <property type="entry name" value="LeuA_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013709">
        <property type="entry name" value="2-isopropylmalate_synth_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002034">
        <property type="entry name" value="AIPM/Hcit_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005668">
        <property type="entry name" value="IPM_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054692">
        <property type="entry name" value="LeuA-like_post-cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036230">
        <property type="entry name" value="LeuA_allosteric_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039371">
        <property type="entry name" value="LeuA_N_DRE-TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00970">
        <property type="entry name" value="leuA_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002991">
        <property type="entry name" value="PRK03739.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46911">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46911:SF1">
        <property type="entry name" value="2-ISOPROPYLMALATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22615">
        <property type="entry name" value="IPMS_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08502">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00917">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110921">
        <property type="entry name" value="2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89000">
        <property type="entry name" value="post-HMGL domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00815">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00816">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="13" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="15">
        <location>
            <begin position="33"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="620"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="620"/>
            <end position="633"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CBF88679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="648" mass="71400" checksum="C4E72334FD1D13CA" modified="2009-11-03" version="1">MPMLKDPSKKYRPFKPLSLPDRQWPNKVIDKPPRWLATDLRDGNQSLPDPMDGEQKLRFFKMLVEIGYKEIEVSFPSASQIDFDFTRSLVETPGLTPDDVWLQVLSPCREDLIRRTVDSLKGAKKAILHIYLATSPCFRRIVFNMDKQQSLEMAVRCTKYARSITKDDPSTAGTEWQLEFSPETFSDTEPEFAAEVCEAVKAAWEPTAERPIIFNLPATVEMTTPNVFADQIEYFCRNVSEREKYVVSVHPHNDRGCAIAAAELAQMAGAQRVEGTLFGNGERTGNVDLVTLALNLYTQGISPKVDFSDINAVIKVVEESNKIPVNERWPYGGQLVVCAFSGSHQDAIKKGFKLREDAGASDDIRWEIPYLPLDPQDIGRTYEAVIRVNSQSGKGGAAWVILRTLELDLPRALQVEFSKIVQKRTEEANRELRPAEIVALFEDAYHLKTNPRFNLVDYNITTDRSQSPAPPEPGKALNTKNLKRRFTGIIEIDGLQHAITGVGNGALSSLANALATLGIDLDVIDYKEHSIGQGAGKGRDVKAATYIHCSAAGSQQKVWGVGIHQDVVQASLIALLSAASSFLTSRAGSPAPFRPIRSNTLTDEDLQALEQLASSNGAGVTVANVSEGQSDSKPTVDLEALTKKAASQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2025-10-08" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>C8VQL1</accession>
    <name>C8VQL1_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WD repeat protein (AFU_orthologue AFUA_5G11870)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ANIA_10017</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat WDR48 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF90172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_657719.2">
        <property type="nucleotide sequence ID" value="XM_652627.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VQL1"/>
    <dbReference type="FunCoup" id="C8VQL1">
        <property type="interactions" value="83"/>
    </dbReference>
    <dbReference type="STRING" id="227321.C8VQL1"/>
    <dbReference type="GeneID" id="2875896"/>
    <dbReference type="KEGG" id="ani:ANIA_10017"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN10017"/>
    <dbReference type="eggNOG" id="KOG0308">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002197_0_0_1"/>
    <dbReference type="InParanoid" id="C8VQL1"/>
    <dbReference type="OMA" id="PMWLGDV"/>
    <dbReference type="OrthoDB" id="2421129at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd17041">
        <property type="entry name" value="Ubl_WDR48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001614">
        <property type="entry name" value="WD repeat protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051246">
        <property type="entry name" value="WDR48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021772">
        <property type="entry name" value="WDR48/Bun107"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19862">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19862:SF14">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11816">
        <property type="entry name" value="DUF3337"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="20"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="77"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="121"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="210"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="339"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="647"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="967"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="354"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="371"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="390"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="647"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="726"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="968"/>
            <end position="1010"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBF90172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="1010" mass="109952" checksum="999EF928B34B1808" modified="2009-11-03" version="1">MARKLSHQRVTYVLPPSDAPGGHRLGVNGLAIDSASSILYSAGRDGVICSWDLDLPSLTSSSSSARQPGPTKFRNQVQAHTHWVNDIVLTQNNSALVTASSDTTVRLWRPHSESTDVPEPIGKHTDYVKALASPGSHSTWVASGGLDHKVNLWDLNGNGQILSIGASGAERSAKGSVYALGAVSSVIASGGPEKLVRVWDPKSGKLITKFVGHTDNIRDILINSDGDTIMTASSDQTVKIWSLTAGRCMHTLTMHNDSVWSLYSNHPNLSVFYSSDRSGLVAKTDTRNVSDIEQGICVAALQEHEGVVKVVAAGDYIWTATPKSSINRWSDVDTAAEIDAPRARGGPDSDAAQSDDKSPPKEKPTKVPFESLLLLSNTSTLPSSRIPQGDSASNGQSSSPRQDIDDELGLTLPAYSLPEETVEGQHGLIKYCLLNDRKRTLTQDSAGEVVLWDLLRCVPIKSFGKRHMDDVELEVNTNESVAHWCTIDIRTGRLSVILEPGRCFDAEIYADEADLADYSQIREDQRLNLGKWVLRWLFAPLVDELVKRDAEYRAEAKARAEEMVKSHSVSAPVDIPGKLTVPIPSDPSAVPGRDSIASPTTPFSIGLATTPGSLTSSVLNHGHSYNNLGMSPGESYDHLTSHHSVDMARSSMSDRSSDYFSSPKSHAAIDSDKPLPTPGEQTPTPAAASEPDKEERKKGGSLFGKKFRMDFPKKLGRTSSEVKPQIQEEKAEEPEKTSVKEEKVFENNLSGLIDRTRHEYEEYLTANPGQELVSAFTPSDESEAPALDIPARTVVFIQEESGDSVVASDIYRGTLENISQDREKLEKTVPLWLGDLLLKNQMPIKEPVKIAFTLRPYDDLLPPVVKPETPSLNGTSNNSRLNANRMLRAKKILAYVSERIEEPTNDPLQDALKPEEYLELYCQNKLIPPNMTLATIRVTHWRNATDMVLHYKANGKKAIRLIGSANDANGQGEAQSNQQSQSESCAVPNGEEASASHGSTASGSVSTNIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>C8VR94</accession>
    <name>C8VR94_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Zn(II)2Cys6 transcription factor (Eurofung)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ANIA_00742</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF88873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050469145.1">
        <property type="nucleotide sequence ID" value="XM_050613319.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VR94"/>
    <dbReference type="GeneID" id="2876519"/>
    <dbReference type="KEGG" id="ani:ANIA_00742"/>
    <dbReference type="eggNOG" id="ENOG502RZ6G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011910_0_0_1"/>
    <dbReference type="InParanoid" id="C8VR94"/>
    <dbReference type="OMA" id="YCARSQA"/>
    <dbReference type="OrthoDB" id="5296287at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053230">
        <property type="entry name" value="Trans_reg_galc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47654:SF3">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47654">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="36"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBF88873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="791" mass="88070" checksum="0BD83B23DF86FDF5" modified="2009-11-03" version="1">MTSDFQGPPRTLAPLPVSQYLGQPRPVPRISKRSNACTACKTRRIKCRGSKPCDNCAATNRTCVFLVENDRRRKNALRRAEQELNTVQQHLDRILEVFKAGDKTQLDYLLATAAEFRTASTLGPALQDGMFAGIDQSAPGLPESSWSTPPSFPTPFFIPVGIPGQGEFLTKDPNRDEASRATGYIGSSSEIDWLQELGNKVNNSTKHTGQQCWPNIDDSAAAMNYHLDYTPLPETIPTDQRSLPPKPWAKTLVGLFFETVYPSFPVVSKSLFIIQFEQAYTFSAVQPSRKWLAVLNLILALGSRYYQETEPVSGRDVDDRVYISRALALASTPATRTSYAGLQQVQVEVLLAIYYLASGHVNQSWQTNGRAARLAISMGLNLWADGDQIDPVSKETRTRIRWSIFTLEHALSGMTGRPSCIDSQFMSVRLPLPFDEAQFQTPGVEELLKASAARERKLQWTVHATDAELDARDQWFVTIRPRQSLYFFHLVDLSVIMQAASRAIYCLTTANDGAEGNITFYRGKLKSWLSSLQPAFAFTTDSANARRRSSGEMPVLASHCRERTGLALAYYSSQVVLTRSCLTYPEVQFGTSAQTSRSRFGDDTAKSCVHFALALVSVLPDQPDMKWISKLTSWWFLLHSIMRALTVLLIQLSIGQVPVRSISGEREGIAREGEGSDAVRDAIKKILLWLHSMAKQDPSSKRAFHIGQRIFAAIARTNGLDLQGVASVLMAKEEASNLEDLDRGSFYPESSKMQVDFADWGPDVTGSESGYEQDQVPFVDPALLSFEEYRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>C8VU04</accession>
    <name>C8VU04_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_11268</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF89698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050469252.1">
        <property type="nucleotide sequence ID" value="XM_050610975.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VU04"/>
    <dbReference type="GeneID" id="74896878"/>
    <dbReference type="KEGG" id="ani:ANIA_11268"/>
    <dbReference type="HOGENOM" id="CLU_2386139_0_0_1"/>
    <dbReference type="InParanoid" id="C8VU04"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF89698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="94" mass="10173" checksum="A81EC2326AD90407" modified="2009-11-03" version="1">MTVQGNPAANQTSQTNVEAVPSLSSSSSIRSMFTTSIGGTRRSGKVQTQMLHGHSDTGFVFVTGKNNSLHKVVSSELARPRLYRGIMVLHRTIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>C8VUN8</accession>
    <name>C8VUN8_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Crh-like protein</fullName>
            <ecNumber evidence="19">3.2.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">ANIA_00933</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="26" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="26">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the glycosyl hydrolase 16 family. CRH1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.2.-.-" evidence="19"/>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF88498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_658537.2">
        <property type="nucleotide sequence ID" value="XM_653445.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VUN8"/>
    <dbReference type="GeneID" id="2876710"/>
    <dbReference type="KEGG" id="ani:ANIA_00933"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN0933"/>
    <dbReference type="eggNOG" id="ENOG502QQ71">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027506_3_2_1"/>
    <dbReference type="InParanoid" id="C8VUN8"/>
    <dbReference type="OMA" id="DDDNWEG"/>
    <dbReference type="OrthoDB" id="4781at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006030">
        <property type="term" value="P:chitin metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd02183">
        <property type="entry name" value="GH16_fungal_CRH1_transglycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000162">
        <property type="entry name" value="Glycosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017168">
        <property type="entry name" value="CHR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF27">
        <property type="entry name" value="GLYCOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037299">
        <property type="entry name" value="Glycosidase_CRH1_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0134">Cell wall</keyword>
    <keyword evidence="17" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="13 21" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="16" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="11 19" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="12 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="10 23" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="23">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002992284" description="Crh-like protein" evidence="23">
        <location>
            <begin position="20"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="24">
        <location>
            <begin position="28"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="263"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="22">
        <location>
            <begin position="269"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="20">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="20">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="21">
        <location>
            <begin position="25"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00038074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRNR" id="PIRNR037299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR037299-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRSR" id="PIRSR037299-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="CBF88498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="405" mass="42352" checksum="B353AB965FF1FAF4" modified="2009-11-03" version="1">MMYLRYAAALASVLPLAVAQTFTDCNPLEETCDPDPGLNSKTFSSDFTQGESALDGWVKASGDVTFGPDGAEFTVAKKGDAPTIDTDFYFFFGKAEVVMKAAPGVGIVSSIVIESDVLDEVDWEVLGGDTTQVQTNYFGKGDTSSYDRGTFEAVATPQEIFHTYTVTWSPDAISWIIDGNTVRTLNYADAKGGSRFPQTPARLRLGIWAGGDPDNAPGTIEWAGGQTDYSAGPFTMYIKSVHIENTYPGSEYTYSDNSGDWQSIKVDDSTPPQETTKTSSTTTSTAEPTSSTSSDSETTTTTTSATDSETETETSTPTSSSETTSSSSESEPASPTATETGSGSGSGSSSESDSASSTPSDSGSATPTSNETSEDPEFTGAASSLTRSAGGLFTVLGMMAAMLQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-12-14" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G5EAT4</accession>
    <accession>C8V7W2</accession>
    <name>G5EAT4_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein UsgS</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_04578</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF77219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_662182.1">
        <property type="nucleotide sequence ID" value="XM_657090.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G5EAT4"/>
    <dbReference type="GeneID" id="2872377"/>
    <dbReference type="KEGG" id="ani:ANIA_04578"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN4578"/>
    <dbReference type="eggNOG" id="ENOG502QW50">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045443_0_0_1"/>
    <dbReference type="InParanoid" id="G5EAT4"/>
    <dbReference type="OMA" id="FMESLKW"/>
    <dbReference type="OrthoDB" id="10041630at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38421:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38421">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN USGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="269"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="343"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF77219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="362" mass="40922" checksum="878857F7CBF5D0F2" modified="2011-12-14" version="1">MSSFEPNAVIRGAQLTVVGTVRALINPRLFKYDHFRQAALAIGIGIIIQLIIQIPIISLRLLIWITSWIVNLEDATWDDALLNSLDFLNKSVLQVPFLLMTLLRYLVPTLDEIFMDSLNWVDTTYVHKHKTDDPNTLRAMYYPNLVQYPTANGKGESKPVVKKLMAFLKRYGRKVGMLLGIYLVSLVPVVGRFVMPAASFYTFHRAVGTTPAAVIFGTGILLPKRYLVTFLHSYFASRSLMRELLEPYFSRIPFTSEQKSRWFKDREGVLFGFAFAFTFVLKIPIIGVLMYGIAEASTAYLITKITDPPPSPAESEGFAETQVTWKNKHDFLRLSLDNIDKLNVAAHEQPSPKPATPGRKFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-12-14" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>G5EB33</accession>
    <accession>C8VLG6</accession>
    <name>G5EB33_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ANIA_02037</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF86057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_659641.1">
        <property type="nucleotide sequence ID" value="XM_654549.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G5EB33"/>
    <dbReference type="GeneID" id="2875065"/>
    <dbReference type="KEGG" id="ani:ANIA_02037"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN2037"/>
    <dbReference type="eggNOG" id="ENOG502QTQ8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044876_1_1_1"/>
    <dbReference type="InParanoid" id="G5EB33"/>
    <dbReference type="OMA" id="PEYAKNQ"/>
    <dbReference type="OrthoDB" id="419598at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0000317"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="CDD" id="cd05259">
        <property type="entry name" value="PCBER_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045312">
        <property type="entry name" value="PCBER-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF8">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="17"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBF86057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="336" mass="36309" checksum="6D6C2CB18B85C5A0" modified="2011-12-14" version="1">MSFAKDQPASFTNAIERVAIVGAGGTVGSVIAGALLKTGKHTVTALTRKDSTNTLPEGVVVAPIDYNDEASIVDALRGQQFFIITVAPTAPRDTHSKLVQAAAKAGVPYIMPNGYGGDIEHVKFGQDVMLGPVAQANRDEIDKLGMKWITVCCGFWYDYSLAGRPARFGFDFDKKELTIYGDGNTKTSVSTLAQVGRAVATVLSLKVLPDGENDKSLTLSSWFNKPVYLQSFVISQNEMFESVKRVTGTADANWTITKEDVHERYADGLKMVKTGNMAGFAKLLYARAFFPEDAGNHSDKAQNKLLGLPEENLDEATQVGIGMVKALQSRAERMAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-12-14" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>G5EB59</accession>
    <accession>C8VEW7</accession>
    <name>G5EB59_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">Dolichyl-phosphate-mannose--protein mannosyltransferase</fullName>
            <ecNumber evidence="4 14">2.4.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">ANIA_05105</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="18">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17377"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:13546"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137321"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 14">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53396"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:13547"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137323"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Endoplasmic reticulum membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the glycosyltransferase 39 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.109" evidence="4 14"/>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF80869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_662709.1">
        <property type="nucleotide sequence ID" value="XM_657617.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G5EB59"/>
    <dbReference type="FunCoup" id="G5EB59">
        <property type="interactions" value="930"/>
    </dbReference>
    <dbReference type="STRING" id="227321.G5EB59"/>
    <dbReference type="CAZy" id="GT39">
        <property type="family name" value="Glycosyltransferase Family 39"/>
    </dbReference>
    <dbReference type="GeneID" id="2871398"/>
    <dbReference type="KEGG" id="ani:ANIA_05105"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN5105"/>
    <dbReference type="eggNOG" id="KOG3359">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008438_5_0_1"/>
    <dbReference type="InParanoid" id="G5EB59"/>
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            <dbReference type="Proteomes" id="UP000000560"/>
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    </evidence>
    <sequence length="740" mass="84556" checksum="C7087C39ECEA943F" modified="2011-12-14" version="1">MAEIGFASTTGASFAPDVRRRNVRTEGQARTSGLIEPDDKKHKQRPNSYLSALADWEPLIAPILLTVLSMFTRMYRIGRSNIVTWDEAHFGKFGSHYLKREFYFDVHPPLGKMLVGLSGLLAGYNGSFEFKSGETYPEDLNYTFMRLFNAAFGVVCVPLAYLTARELGFRRGTVWLVSLMVLFENSYATISRFILLDSMLLCFTFTTTFCWAKFHRLQHASFSIEWFTWLFLTGVSIGCVCSVKWVGLFCTALVGLYTIEDLWNKFGDLKMSEATLAKHFAVRVVGLILIPALVYIFSFYIHFLILENSGPGDAQMSSLFQANLKGTQVGKDSPLEIAFGSRVTLKNMGYGGGLLHSHVQTYPEGSSQQQVTCYHHKDANNDWFIYPNRKEPQYDAEAPLRFVGDGDVIRLIHGQTGRNLHSHNIPAPITKNHHEVSCYGNLTIGDDKDHWKVEVVDDVASRDRSRIRTLTTAFRLRHAVLGCYLRAGNTNLPQWGFKQIETTCVKENKPRDVYTHWNIETHTNDRLPPGDPGSYKSPFFKDFVHLNVAMMTSNNALVPDPDKQDDLASKPWQWPILNVGLRMCSWDEKVVKYYLLGNPVVYWGSTLSLAVFGLLTLWYLVRWQRGYNELSQADIDHIHYAGLYPVLGWFLHYVPFIAMARVTYVHHYYPALYYAILTFGFCVDWLTKTLNTKVRFLVYGLLYALVAGVFVYFRVIVFGIEGPSQQWRHLNWLSGWRIAN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1997-11-01" modified="2026-01-28" version="152" xmlns="https://uniprot.org/uniprot">
    <accession>Q00681</accession>
    <accession>C8VDT8</accession>
    <accession>Q5AV65</accession>
    <name>STCJ_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Fatty acid synthase alpha subunit stcJ</fullName>
            <ecNumber evidence="3">2.3.1.86</ecNumber>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="3">3-oxoacyl-[acyl-carrier-protein] reductase</fullName>
                <ecNumber evidence="3">1.1.1.100</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="3">3-oxoacyl-[acyl-carrier-protein] synthase</fullName>
                <ecNumber evidence="3">2.3.1.41</ecNumber>
            </alternativeName>
            <alternativeName>
                <fullName evidence="17">Sterigmatocystin biosynthesis cluster protein J</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="17" type="primary">stcJ</name>
        <name type="ORF">AN7815</name>
    </gene>
    <organism>
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1996" name="Proc. Natl. Acad. Sci. U.S.A." volume="93" first="1418" last="1422">
            <title>Twenty-five coregulated transcripts define a sterigmatocystin gene cluster in Aspergillus nidulans.</title>
            <authorList>
                <person name="Brown D.W."/>
                <person name="Yu J.-H."/>
                <person name="Kelkar H.S."/>
                <person name="Fernandes M."/>
                <person name="Nesbitt T.C."/>
                <person name="Keller N.P."/>
                <person name="Adams T.H."/>
                <person name="Leonard T.J."/>
            </authorList>
            <dbReference type="PubMed" id="8643646"/>
            <dbReference type="DOI" id="10.1073/pnas.93.4.1418"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <scope>INDUCTION</scope>
        <scope>FUNCTION</scope>
        <scope>PATHWAY</scope>
        <source>
            <strain>FGSC 26</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="1994" name="Appl. Environ. Microbiol." volume="60" first="1444" last="1450">
            <title>Aspergillus nidulans verA is required for production of the mycotoxin sterigmatocystin.</title>
            <authorList>
                <person name="Keller N.P."/>
                <person name="Kantz N.J."/>
                <person name="Adams T.H."/>
            </authorList>
            <dbReference type="PubMed" id="8017929"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="1995" name="Appl. Environ. Microbiol." volume="61" first="3628" last="3632">
            <title>StcS, a putative P-450 monooxygenase, is required for the conversion of versicolorin A to sterigmatocystin in Aspergillus nidulans.</title>
            <authorList>
                <person name="Keller N.P."/>
                <person name="Segner S."/>
                <person name="Bhatnagar D."/>
                <person name="Adams T.H."/>
            </authorList>
            <dbReference type="PubMed" id="7486998"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="1995" name="J. Bacteriol." volume="177" first="4792" last="4800">
            <title>Sterigmatocystin biosynthesis in Aspergillus nidulans requires a novel type I polyketide synthase.</title>
            <authorList>
                <person name="Yu J.-H."/>
                <person name="Leonard T.J."/>
            </authorList>
            <dbReference type="PubMed" id="7642507"/>
        </citation>
        <scope>FUNCTION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="7">
        <citation type="journal article" date="1996" name="Appl. Environ. Microbiol." volume="62" first="4296" last="4298">
            <title>Aspergillus nidulans stcP encodes an O-methyltransferase that is required for sterigmatocystin biosynthesis.</title>
            <authorList>
                <person name="Kelkar H.S."/>
                <person name="Keller N.P."/>
                <person name="Adams T.H."/>
            </authorList>
            <dbReference type="PubMed" id="8900026"/>
            <dbReference type="DOI" id="10.1128/aem.62.11.4296-4298.1996"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="8">
        <citation type="journal article" date="1996" name="Proc. Natl. Acad. Sci. U.S.A." volume="93" first="14873" last="14877">
            <title>Aspergillus has distinct fatty acid synthases for primary and secondary metabolism.</title>
            <authorList>
                <person name="Brown D.W."/>
                <person name="Adams T.H."/>
                <person name="Keller N.P."/>
            </authorList>
            <dbReference type="PubMed" id="8962148"/>
            <dbReference type="DOI" id="10.1073/pnas.93.25.14873"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>PATHWAY</scope>
    </reference>
    <reference key="9">
        <citation type="journal article" date="1997" name="J. Biol. Chem." volume="272" first="1589" last="1594">
            <title>Aspergillus nidulans stcL encodes a putative cytochrome P-450 monooxygenase required for bisfuran desaturation during aflatoxin/sterigmatocystin biosynthesis.</title>
            <authorList>
                <person name="Kelkar H.S."/>
                <person name="Skloss T.W."/>
                <person name="Haw J.F."/>
                <person name="Keller N.P."/>
                <person name="Adams T.H."/>
            </authorList>
            <dbReference type="PubMed" id="8999832"/>
            <dbReference type="DOI" id="10.1074/jbc.272.3.1589"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="10">
        <citation type="journal article" date="1998" name="Mol. Microbiol." volume="28" first="1355" last="1365">
            <title>Sequence-specific binding by Aspergillus nidulans aflR, a C6 zinc cluster protein regulating mycotoxin biosynthesis.</title>
            <authorList>
                <person name="Fernandes M."/>
                <person name="Keller N.P."/>
                <person name="Adams T.H."/>
            </authorList>
            <dbReference type="PubMed" id="9680223"/>
            <dbReference type="DOI" id="10.1046/j.1365-2958.1998.00907.x"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="11">
        <citation type="journal article" date="2000" name="Appl. Environ. Microbiol." volume="66" first="359" last="362">
            <title>Requirement of monooxygenase-mediated steps for sterigmatocystin biosynthesis by Aspergillus nidulans.</title>
            <authorList>
                <person name="Keller N.P."/>
                <person name="Watanabe C.M."/>
                <person name="Kelkar H.S."/>
                <person name="Adams T.H."/>
                <person name="Townsend C.A."/>
            </authorList>
            <dbReference type="PubMed" id="10618248"/>
            <dbReference type="DOI" id="10.1128/aem.66.1.359-362.2000"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="12">
        <citation type="journal article" date="2012" name="Metabolites" volume="2" first="100" last="133">
            <title>Genetics of polyketide metabolism in Aspergillus nidulans.</title>
            <authorList>
                <person name="Klejnstrup M.L."/>
                <person name="Frandsen R.J."/>
                <person name="Holm D.K."/>
                <person name="Nielsen M.T."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen J.B."/>
            </authorList>
            <dbReference type="PubMed" id="24957370"/>
            <dbReference type="DOI" id="10.3390/metabo2010100"/>
        </citation>
        <scope>REVIEW ON STERIGMATOCYSTIN BIOSYNTHESIS</scope>
    </reference>
    <comment type="function">
        <text evidence="2 8 9 11 12 13 14 16 19">Fatty acid synthase alpha subunit; part of the gene cluster that mediates the biosynthesis of sterigmatocystin (ST), a polyketide-derived furanocoumarin which is part of the most toxic and carcinogenic compounds among the known mycotoxins (PubMed:8643646, PubMed:8962148). The first step in the biosynthesis of sterigmatocystin is the production of hexanoate by the fatty acid synthase (FAS) units stcJ and stcK (PubMed:8962148). The polyketide backbone is assembled by the non-reducing polyketide synthase stcA by condensation of the starter hexanoyl-CoA and 7 malonyl-CoA extender units followed by cyclization and release of norsolorinic acid (By similarity). Norsolorinic acid is the first stable intermediate in the biosynthesis of sterigmatocystin and is converted into averantin (AVN) by the ketoreductase stcE which reduces the hexanoate ketone to an alcohol (Probable) (PubMed:8643646). Averantin is then oxidized into 5'-hydroxyaverantin (HAVN) by the cytochrome P450 monooxygenase stcF (PubMed:10618248). 5'-hydroxyaverantin is further converted to 5'-oxyaverantin (OAVN) by the 5'-hydroxyaverantin dehydrogenase stcG (PubMed:24957370). The next step is the conversion of OAVN into averufin (AVF) which is catalyzed by a yet to be identified enzyme (PubMed:24957370). The cytochrome P450 monooxygenase stcB and the flavin-binding monooxygenase stcW are both required for the conversion of averufin to 1-hydroxyversicolorone (PubMed:10618248). The esterase stcI probably catalyzes the formation of versiconal hemiacetal acetate from 1-hydroxyversicolorone (PubMed:24957370). The oxydoreductase stcN then probably catalyzes the biosynthetic step from versiconal to versicolorin B (VERB) (PubMed:24957370). The next step is performed by the versicolorin B desaturase stcL to produce versicolorin A (VERA) (PubMed:8999832). The ketoreductase stcU and the cytochrome P450 monooxygenase stcS are involved in the conversion of versicolorin A to demethylsterigmatocystin (PubMed:7486998). The Baeyer-Villiger oxidas stcQ and the reductase stcR might be involved in the biosynthetic step from versicolorin A to demethylsterigmatocystin (PubMed:24957370). The final step in the biosynthesis of sterigmatocystin is the methylation of demethylsterigmatocystin catalyzed by the methyltransferase stcP (PubMed:8900026).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>acetyl-CoA + n malonyl-CoA + 2n NADPH + 4n H(+) = a long-chain-acyl-CoA + n CoA + n CO2 + 2n NADP(+).</text>
            <dbReference type="EC" id="2.3.1.86"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a fatty acyl-[ACP] + malonyl-[ACP] + H(+) = a 3-oxoacyl-[ACP] + holo-[ACP] + CO2</text>
            <dbReference type="Rhea" id="RHEA:22836"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:14125"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:138651"/>
            <dbReference type="EC" id="2.3.1.41"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a (3R)-hydroxyacyl-[ACP] + NADP(+) = a 3-oxoacyl-[ACP] + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17397"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="EC" id="1.1.1.100"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="11 13">Mycotoxin biosynthesis; sterigmatocystin biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">[Alpha(6)beta(6)] hexamers of two multifunctional subunits (alpha and beta).</text>
    </comment>
    <comment type="induction">
        <text evidence="10 11 15">The genes forming the sterigmatocystin biosynthesis cluster are co-regulated and induced on oatmeal porridge or the fungal isolates were grown either on oatmeal porridge or in YEC medium (0.2% yeast extract, 5.0% corn steep liquor) (PubMed:8017929, PubMed:8643646). Expression is positively regulated by the cluster-specific transcription factor aflR that binds the palindromic sequence 5'-TCG(N5)CGA-3'found in the promoter (PubMed:9680223).</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="13">Fails to produce sterigmatocystin under conditions that supports production by wild-type. Able to grow without exogenous long-chain fatty acids.</text>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the thiolase-like superfamily. Fungal fatty acid synthetase subunit alpha family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.86" evidence="3"/>
    <dbReference type="EC" id="1.1.1.100" evidence="3"/>
    <dbReference type="EC" id="2.3.1.41" evidence="3"/>
    <dbReference type="EMBL" id="U34740">
        <property type="protein sequence ID" value="AAC49198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AACD01000132">
        <property type="protein sequence ID" value="EAA61603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF80164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_681084.1">
        <property type="nucleotide sequence ID" value="XM_675992.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q00681"/>
    <dbReference type="SMR" id="Q00681"/>
    <dbReference type="STRING" id="227321.Q00681"/>
    <dbReference type="EnsemblFungi" id="CBF80164">
        <property type="protein sequence ID" value="CBF80164"/>
        <property type="gene ID" value="ANIA_07815"/>
    </dbReference>
    <dbReference type="KEGG" id="ani:ANIA_07815"/>
    <dbReference type="eggNOG" id="ENOG502SH82">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000114_0_0_1"/>
    <dbReference type="InParanoid" id="Q00681"/>
    <dbReference type="OMA" id="VGVAPKY"/>
    <dbReference type="OrthoDB" id="4251012at2759"/>
    <dbReference type="UniPathway" id="UPA00377"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005835">
        <property type="term" value="C:fatty acid synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004321">
        <property type="term" value="F:fatty-acyl-CoA synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008897">
        <property type="term" value="F:holo-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042759">
        <property type="term" value="P:long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045461">
        <property type="term" value="P:sterigmatocystin biosynthetic process"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00828">
        <property type="entry name" value="elong_cond_enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08950">
        <property type="entry name" value="KR_fFAS_SDR_c_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.20">
        <property type="entry name" value="4'-phosphopantetheinyl transferase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008278">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037143">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040899">
        <property type="entry name" value="Fas_alpha_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047224">
        <property type="entry name" value="FAS_alpha_su_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026025">
        <property type="entry name" value="FAS_alpha_yeast"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041550">
        <property type="entry name" value="FASI_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050830">
        <property type="entry name" value="Fungal_FAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004568">
        <property type="entry name" value="Ppantetheine-prot_Trfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00556">
        <property type="entry name" value="pantethn_trn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10982:SF21">
        <property type="entry name" value="FATTY ACID SYNTHASE SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10982">
        <property type="entry name" value="MALONYL COA-ACYL CARRIER PROTEIN TRANSACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01648">
        <property type="entry name" value="ACPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18325">
        <property type="entry name" value="Fas_alpha_ACP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18314">
        <property type="entry name" value="FAS_I_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000454">
        <property type="entry name" value="FAS_yeast_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56214">
        <property type="entry name" value="4'-phosphopantetheinyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword id="KW-0276">Fatty acid metabolism</keyword>
    <keyword id="KW-0444">Lipid biosynthesis</keyword>
    <keyword id="KW-0443">Lipid metabolism</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0511">Multifunctional enzyme</keyword>
    <keyword id="KW-0521">NADP</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-0596">Phosphopantetheine</keyword>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0843">Virulence</keyword>
    <feature type="chain" id="PRO_0000180289" description="Fatty acid synthase alpha subunit stcJ">
        <location>
            <begin position="1"/>
            <end position="1559"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="68"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="6">
        <location>
            <begin position="873"/>
            <end position="1327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Ketoreductase (KR) domain" evidence="3 4">
        <location>
            <begin position="457"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1105"/>
            <end position="1125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1105"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="active site" description="For beta-ketoacyl synthase activity" evidence="6">
        <location>
            <position position="1058"/>
        </location>
    </feature>
    <feature type="active site" description="For beta-ketoacyl synthase activity" evidence="6">
        <location>
            <position position="1212"/>
        </location>
    </feature>
    <feature type="active site" description="For beta-ketoacyl synthase activity" evidence="6">
        <location>
            <position position="1253"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="1432"/>
            <end position="1434"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="1432"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="1480"/>
            <end position="1490"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="1504"/>
            <end position="1506"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="1532"/>
            <end position="1534"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="1533"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="5">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; AAC49198." evidence="18" ref="1">
        <original>T</original>
        <variation>N</variation>
        <location>
            <position position="215"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; AAC49198." evidence="18" ref="1">
        <original>A</original>
        <variation>P</variation>
        <location>
            <position position="456"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; AAC49198." evidence="18" ref="1">
        <original>I</original>
        <variation>S</variation>
        <location>
            <position position="1192"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P19097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="Q12053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="3">
        <source>
            <dbReference type="UniProtKB" id="Q8TGA2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="4"/>
    <evidence type="ECO:0000255" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="8">
        <source>
            <dbReference type="PubMed" id="10618248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="9">
        <source>
            <dbReference type="PubMed" id="7486998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="10">
        <source>
            <dbReference type="PubMed" id="8017929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="11">
        <source>
            <dbReference type="PubMed" id="8643646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="12">
        <source>
            <dbReference type="PubMed" id="8900026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="13">
        <source>
            <dbReference type="PubMed" id="8962148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="14">
        <source>
            <dbReference type="PubMed" id="8999832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="15">
        <source>
            <dbReference type="PubMed" id="9680223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="16">
        <source>
            <dbReference type="PubMed" id="24957370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="17">
        <source>
            <dbReference type="PubMed" id="8643646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="18"/>
    <evidence type="ECO:0000305" key="19">
        <source>
            <dbReference type="PubMed" id="8643646"/>
        </source>
    </evidence>
    <sequence length="1559" mass="170114" checksum="41AF9FC53973B3B4" modified="2009-05-26" version="2">MTQKTIQQVPRQGLELLASTQDLAQLCYIYGEPAEGEDSTADESIINTPQCSTIPEVAVEPEVQPIPDTPLTAIFIIRALVARKLRRSETEIDPSRSIKELCGGKSTLQNELIGELGNEFQTSLPDRAEDVSLADLDAALGEVSLGPTSVSLLQRVFTAKMPARMTVSNVRERLAEIWGLGFHRQTAVLVAALAAEPHSRLTSLEAAYQYWDGLTEAYGQSLGLFLRKAISQQAARSDDQGAQAIAPADSLGSKDLARKQYEALREYLGIRTPTTKQDGLDLADLQQKLDCWTAEFSDDFLSQISRRFDARKTRWYRDWWNSARQELLTICQNSNVQWTDKMREHFVQRAEEGLVEIARAHSLAKPLVPDLIQAISLPPVVRLGRLATMMPRTVVTLKGEIQCEEHEREPSCFVEFFSSWIQANNIRCTIQSNGEDLTSVFINSLVHASQQGVSFANHTYLITGAGPGSIGQHIVRRLLTGGARVIVTTSREPLPAAAFFKELYSKCGNRGSQLHLVPFNQASVVDCERLIGYIYDDLGLDLDAILPFAATSQVGAEIDGLDASNEAAFRLMLVNVLRLVGFVVSQKRRRGISCRPTQVVLPLSPNHGILGGDGLYAESKRGLETLIQRFHSESWKEELSICGVSIGWTRSTGLMAANDLVAETAEKQGRVLTFSVDEMGDLISLLLTPQLATRCEDAPVMADFSGNLSCWRDASAQLAAARASLRERADTARALAQEDEREYRCRRAGSTQEPVDQRVSLHLGFPSLPEYDPLLHPDLVPADAVVVVGFAELGPWGSARIRWEMESRGCLSPAGYVETAWLMNLIRHVDNVNYVGWVDGEDGKPVADADIPKRYGERILSNAGIRSLPSDNREVFQEIVLEQDLPSFETTRENAEALQQRHGDMVQVSTLKNGLCLVQLQHGATIRVPKSIMSPPGVAGQLPTGWSPERYGIPAEIVQQVDPVALVLLCCVAEAFYSAGISDPMEIFEHIHLSELGNFVGSSMGGVVNTRALYHDVCLDKDVQSDALQETYLNTAPAWVNMLYLGAAGPIKTPVGACATALESVDSAVESIKAGQTKICLVGGYDDLQPEESAGFARMKATVSVRDEQARGREPGEMSRPTAASRSGFVESQGCGVQLLCRGDVALAMGLPIYGIIAGTGMASDGIGRSVPAPGQGILTFAQEDAQNPAPIRTALARWGLGIDDITVASLHATSTPANDTNEPLVIQREMTHLGRTSGRPLWAICQKFVTGHPKAPAAAWMLNGCLQVLDTGLVPGNRNADDVDPALRSFSHLCFPIRSIQTDGIKAFLLNSCGFGQKEAQLVGVHPRYFLGLLSEPEFEEYRTRRQLRIAGAERAYISAMMTNSIVCVQSHPPFGPAEMHSILLDPSARICLDSSTNSYRVTKASTPVYTGFQRPHDKREDPRPSTIGVDTVTLSSFNAHENAIFLQRNYTERERQSLQLQSHRSFRSAVASGWCAKEAVFKCLQTVSKGAGAAMSEIEIVRVQGAPSVLHGDALAAAQKAGLDNIQLSLSYGDDCVVAVALGVRKWCLWPLASIIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="103" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AQ92</accession>
    <accession>C8VM17</accession>
    <name>Q5AQ92_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">C2H2 finger domain protein, putative (AFU_orthologue AFUA_2G16230)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ANIA_09538</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF86243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_868920.1">
        <property type="nucleotide sequence ID" value="XM_863827.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AQ92"/>
    <dbReference type="STRING" id="227321.Q5AQ92"/>
    <dbReference type="GeneID" id="3684137"/>
    <dbReference type="KEGG" id="ani:ANIA_09538"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019787_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AQ92"/>
    <dbReference type="OMA" id="FNAKAMY"/>
    <dbReference type="OrthoDB" id="9411774at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF8">
        <property type="entry name" value="C2H2 FINGER DOMAIN TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="3"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="29"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="46"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBF86243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="752" mass="84108" checksum="8FD17C3640929746" modified="2005-04-26" version="1">MNDPCLKCRSTFVRRDLLLRHDRTVHAKDGGVPLVSEGRRRGGGVRKASSPAPSKPSVTIDPTTLEQIEASSDGMVDLETAAMLMTDFQHKAAAAATGQVHDRAESDRSFSPGRGSLLEPPVSYLSGNATLPQMPWDSLVSPTESKHHLSPFVSQDAASESHGLMDRHVTDSMAPSLHSLVNSLPVSGNSTPNALSPYPSMTGPVSPVNYRRSPGPSQALTLPKAPQIANDLERNQIVERIRLADSLGVLPESFQLPTTAALNKYLTTYFNLYHHHLPFLHQESFKPTTASSPLLLAVLSIGALYTFERQHAFMLHVGSKMLVNQFLQHKDNFDSRKCPLWAMQSTLLNMIFESWSGDPKGLEWTCSIKSLLANMVAGNRYQLKLRTEAREGRQPTREEWIEDESCRRTYYAVYIFFGMLTLTFNHTPAMSFDEFDNLELPSSESMWNLDVNDDEAWRRNLASSTTMTVREAHDCLFQGDQTRYSAFATRVLINALFLQVWNHKRSFEALQDVVTEYKLRLALETWENSLEVCEPETIVVPLSTPQNGHPLIFNSMAVYRNTRARLEVDLKSIQEALRYHSSYEVAAAMTVAREKVKRSQEMNKVIQSCFECIEIAAIQGINWVAKTSATNWSVEHPLCGLDLMVILSLWLYRLEHDEEPASEAEMAIYNKVRNLFDDDAVDSCGKLSSTVARVWGNILDGVVVWGITKLMGESFKLHSQALVGYEDSLRVAKDQPIHAVPTKSLASVGTAY</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2021-09-29" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AR28</accession>
    <accession>C8VQ89</accession>
    <name>AUSS_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Austinoid biosynthesis clusters protein S</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ausS</name>
        <name type="ORF">AN9252</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2012" name="ACS Chem. Biol." volume="7" first="599" last="606">
            <title>Signaling the induction of sporulation involves the interaction of two secondary metabolites in Aspergillus nidulans.</title>
            <authorList>
                <person name="Rodriguez-Urra A.B."/>
                <person name="Jimenez C."/>
                <person name="Nieto M.I."/>
                <person name="Rodriguez J."/>
                <person name="Hayashi H."/>
                <person name="Ugalde U."/>
            </authorList>
            <dbReference type="PubMed" id="22234162"/>
            <dbReference type="DOI" id="10.1021/cb200455u"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2012" name="J. Am. Chem. Soc." volume="134" first="4709" last="4720">
            <title>Two separate gene clusters encode the biosynthetic pathway for the meroterpenoids austinol and dehydroaustinol in Aspergillus nidulans.</title>
            <authorList>
                <person name="Lo H.C."/>
                <person name="Entwistle R."/>
                <person name="Guo C.J."/>
                <person name="Ahuja M."/>
                <person name="Szewczyk E."/>
                <person name="Hung J.H."/>
                <person name="Chiang Y.M."/>
                <person name="Oakley B.R."/>
                <person name="Wang C.C."/>
            </authorList>
            <dbReference type="PubMed" id="22329759"/>
            <dbReference type="DOI" id="10.1021/ja209809t"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2013" name="J. Am. Chem. Soc." volume="135" first="10962" last="10965">
            <title>Spiro-ring formation is catalyzed by a multifunctional dioxygenase in austinol biosynthesis.</title>
            <authorList>
                <person name="Matsuda Y."/>
                <person name="Awakawa T."/>
                <person name="Wakimoto T."/>
                <person name="Abe I."/>
            </authorList>
            <dbReference type="PubMed" id="23865690"/>
            <dbReference type="DOI" id="10.1021/ja405518u"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2017" name="ACS Chem. Biol." volume="12" first="2927" last="2933">
            <title>Rewiring of the austinoid biosynthetic pathway in filamentous fungi.</title>
            <authorList>
                <person name="Mattern D.J."/>
                <person name="Valiante V."/>
                <person name="Horn F."/>
                <person name="Petzke L."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="29076725"/>
            <dbReference type="DOI" id="10.1021/acschembio.7b00814"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="1 3 4 5 6">Part of the gene cluster B that mediates the biosynthesis of austinol and dehydroaustinol, two fungal meroterpenoids (PubMed:22329759). The first step of the pathway is the synthesis of 3,5-dimethylorsellinic acid by the polyketide synthase ausA (PubMed:22329759). 3,5-dimethylorsellinic acid is then prenylated by the polyprenyl transferase ausN (PubMed:22329759). Further epoxidation by the FAD-dependent monooxygenase ausM and cyclization by the probable terpene cyclase ausL lead to the formation of protoaustinoid A (PubMed:22329759). Protoaustinoid A is then oxidized to spiro-lactone preaustinoid A3 by the combined action of the FAD-binding monooxygenases ausB and ausC, and the dioxygenase ausE (PubMed:22329759, PubMed:23865690). Acid-catalyzed keto-rearrangement and ring contraction of the tetraketide portion of preaustinoid A3 by ausJ lead to the formation of preaustinoid A4 (PubMed:22329759). The aldo-keto reductase ausK, with the help of ausH, is involved in the next step by transforming preaustinoid A4 into isoaustinone which is in turn hydroxylated by the P450 monooxygenase ausI to form austinolide (PubMed:22329759). Finally, the cytochrome P450 monooxygenase ausG modifies austinolide to austinol (PubMed:22329759). Austinol can be further modified to dehydroaustinol which forms a diffusible complex with diorcinol that initiates conidiation (PubMed:22234162, PubMed:22329759). Due to genetic rearrangements of the clusters and the subsequent loss of some enzymes, the end products of the Emericella nidulans austinoid biosynthesis clusters are austinol and dehydroaustinol, even if additional enzymes, such as the O-acetyltransferase ausQ and the cytochrome P450 monooxygenase ausR are still functional (PubMed:29076725). AusS is necessary for austinoids production and may play a possible function as a regulator.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Secondary metabolite biosynthesis; terpenoid biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="9">In A.calidoustus, the austinoid gene cluster lies on a contiguous DNA region, while clusters from E.nidulans and P.brasilianum are split in their respective genomes. Genetic rearrangements provoked variability among the clusters and E.nidulans produces the least number of austionoid derivatives with the end products austinol and dehydroaustinol, while P.brasilianum can produce until acetoxydehydroaustin, and A.calidoustus produces the highest number of identified derivatives.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the trt14 isomerase family.</text>
    </comment>
    <comment type="sequence caution" evidence="8">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="EAA66319" version="1"/>
        </conflict>
        <text>Extended N-terminus.</text>
    </comment>
    <dbReference type="EMBL" id="AACD01000172">
        <property type="protein sequence ID" value="EAA66319.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF87251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AR28"/>
    <dbReference type="SMR" id="Q5AR28"/>
    <dbReference type="STRING" id="227321.C8VQ89"/>
    <dbReference type="EnsemblFungi" id="CBF87251">
        <property type="protein sequence ID" value="CBF87251"/>
        <property type="gene ID" value="ANIA_09252"/>
    </dbReference>
    <dbReference type="KEGG" id="ani:ANIA_09252"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN9252"/>
    <dbReference type="eggNOG" id="ENOG502S4TQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108113_3_0_1"/>
    <dbReference type="InParanoid" id="Q5AR28"/>
    <dbReference type="OMA" id="LRCETIV"/>
    <dbReference type="OrthoDB" id="3758478at2759"/>
    <dbReference type="UniPathway" id="UPA00213"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900560">
        <property type="term" value="P:austinol biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900563">
        <property type="term" value="P:dehydroaustinol biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050977">
        <property type="entry name" value="Fungal_Meroterpenoid_Isomerase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39598:SF1">
        <property type="entry name" value="AUSTINOID BIOSYNTHESIS CLUSTERS PROTEIN F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39598">
        <property type="entry name" value="AUSTINOL SYNTHESIS PROTEIN F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000453834" description="Austinoid biosynthesis clusters protein S">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="A0A0U5CJU2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="Q5AR31"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="22234162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="22329759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="23865690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="6">
        <source>
            <dbReference type="PubMed" id="29076725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="7">
        <source>
            <dbReference type="PubMed" id="29076725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="8"/>
    <evidence type="ECO:0000305" key="9">
        <source>
            <dbReference type="PubMed" id="29076725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAA66319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000005890"/>
        </source>
    </evidence>
    <sequence length="140" mass="15959" checksum="15ADCF14DD649A78" modified="2021-09-29" version="2">MSIRERLLATVSKYIAAYNEFDPSAMKTVRTPTCLTHGVAPTCKFTQSMEEHTRHMMLSRGVFRSVNASIVDDNITVVDEVSRQVVVKVKIRCETTVGPYENEAMFIMAMNEEGALVDEIFQFLDTARFRQFQGRLEEAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ARU2</accession>
    <accession>C8VL14</accession>
    <name>Q5ARU2_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ANIA_08988</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF84510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_682257.1">
        <property type="nucleotide sequence ID" value="XM_677165.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ARU2"/>
    <dbReference type="STRING" id="227321.Q5ARU2"/>
    <dbReference type="GeneID" id="2868184"/>
    <dbReference type="KEGG" id="ani:ANIA_08988"/>
    <dbReference type="eggNOG" id="KOG1502">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_12_2_1"/>
    <dbReference type="InParanoid" id="Q5ARU2"/>
    <dbReference type="OMA" id="FNDYEGV"/>
    <dbReference type="OrthoDB" id="2130169at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051783">
        <property type="entry name" value="NAD(P)-dependent_oxidoreduct"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079:SF6">
        <property type="entry name" value="NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079">
        <property type="entry name" value="PROTEIN YEEZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF84510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="374" mass="41462" checksum="B150585E8E3AE13D" modified="2005-04-26" version="1">MPKLFITGITGYIGGDAFHLLSQKHRDFEFSALVRTEAKAKYVRELYPNVRIVIGGLDDADKIEKEAAWADIVLHTADSSDHVGAANAIARGLVQGHSLDRPGYWLHTGGTGILTYFDSDVHKVHGEHNDKVFNDYEGVSELTNLPAAAFHRNVDEIVLRTGVEHADRVKTVIVCPPTIYGRGRGPVALRGRQAYELTSFVLKEKYVPIIGKGLARWNNVHIYDLSRLFDLLVRAALDPARKDDKEIWGEKGYFLCENGEHVWGELSKLVGEQAHKLGYLKDAPVVKEMSVDEAISSPAGFEAASWGWNSRGQAQRGREVLGWSPEEKSIEEEIPDILAAEASRLDGQFSLTIMFPPTGETRLLIAVESSFADE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ASH8</accession>
    <accession>C8V9Y9</accession>
    <name>Q5ASH8_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ethanolamine utilization protein (EutQ), putative (AFU_orthologue AFUA_6G02845)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ANIA_08752</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF78098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_682021.1">
        <property type="nucleotide sequence ID" value="XM_676929.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ASH8"/>
    <dbReference type="GeneID" id="2868451"/>
    <dbReference type="KEGG" id="ani:ANIA_08752"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN8752"/>
    <dbReference type="eggNOG" id="ENOG502S3HA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_141740_0_0_1"/>
    <dbReference type="InParanoid" id="Q5ASH8"/>
    <dbReference type="OMA" id="FTYHAKA"/>
    <dbReference type="OrthoDB" id="4985585at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="CDD" id="cd02228">
        <property type="entry name" value="cupin_EutQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010424">
        <property type="entry name" value="EutQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36169:SF1">
        <property type="entry name" value="ACETATE KINASE EUTQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36169">
        <property type="entry name" value="ETHANOLAMINE UTILIZATION PROTEIN EUTQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06249">
        <property type="entry name" value="EutQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF78098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="119" mass="13000" checksum="0C4A18A3446701E3" modified="2005-04-26" version="1">MPTAMVYHAKAQSTFKPPLIANENAFLGDIDSSDSYNPEKPISAGFYRLEKGTPLIYEYTYDEMKIILEGEFEISDETGQTVTAGAGDVLHFPKGSKITFTTPSYGLAFYTGQRAKGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AST0</accession>
    <accession>C8VAB8</accession>
    <name>Q5AST0_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_08650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF78256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_681919.1">
        <property type="nucleotide sequence ID" value="XM_676827.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AST0"/>
    <dbReference type="STRING" id="227321.Q5AST0"/>
    <dbReference type="GeneID" id="2868553"/>
    <dbReference type="KEGG" id="ani:ANIA_08650"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN8650"/>
    <dbReference type="HOGENOM" id="CLU_045552_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AST0"/>
    <dbReference type="OMA" id="RPAQNEV"/>
    <dbReference type="OrthoDB" id="4276722at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010342998" evidence="1">
        <location>
            <begin position="27"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF78256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="496" mass="55910" checksum="C76BB21F35268E8A" modified="2005-04-26" version="1">MVPKRDPGVVAIMLLATLGLYLVSLGEEVPDPLEDRFVFRVLTFLHVQMSESSEATGWQQVRHYKDHLGHPVVLEQYIEEGYDPYSSHLVPIQIYSTVLLDTDHKSLRAYLLQGFYNDAVLPLFEIYSFCPPDAFACIEHNRREIAYRKSQHRLKVPNPPPLIPRFFNACSDRPIGRCLLLRSHSYRLGYVGDWDLYIEAGSAPDDLAFNRSFSRFQADVVEEQRRADGDDELGLAGFELSIERIQCQIDVSQVIVADIFPNAQRPELEYALDTDEGVLANAELPPDVEAEIREQLEKQSTEINYAVESTFRIMDDDAGVVTVTNTSEGDDADLQYLVYAPFLSHWRNVPHSSIPLLKATARLFHHSTSWSSIRPAHSHLIQTLIAPFPVGARHTITVAGSSSEIHRIYPQYLTDTVGAAERMLTNPCRILAVVLDRPNFVEEAGVYFYMSEYTSSVDIPPEMEPQPDDTEVWRVVGMKEVSGLLGMVGVGKGRAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ATA1</accession>
    <accession>C8VEJ1</accession>
    <name>Q5ATA1_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_08479</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF80633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_681748.1">
        <property type="nucleotide sequence ID" value="XM_676656.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ATA1"/>
    <dbReference type="GeneID" id="2868795"/>
    <dbReference type="KEGG" id="ani:ANIA_08479"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN8479"/>
    <dbReference type="eggNOG" id="ENOG502SK1W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008952_0_0_1"/>
    <dbReference type="InParanoid" id="Q5ATA1"/>
    <dbReference type="OMA" id="VRTWNSC"/>
    <dbReference type="OrthoDB" id="74545at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="CDD" id="cd01709">
        <property type="entry name" value="RT_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37015">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37015:SF1">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="386"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="390"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF80633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="901" mass="104122" checksum="FE82BBD6FB9FE4CF" modified="2005-04-26" version="1">MAPHISALSQTLESLTWSKIRELEKQRSLYEDRKAAILAEAERQPDLAARVSVILRGTQAIHPTASKDETVRSIDRWLDQHRFDPSITDGMLRQYEDELRSQLDAHSRKLSLADLYSRLLTEWTNTGDVQGSDGDITEEDYAVVDERQKQRLQQLCDQFEETVFTPLETNAEEIYAFLNELFPGDEERKQLNELREKIADESQEMFEEDAPFDKKALTATIKGLLTEDILSDAKQDVLKGFLKNEVALTEIADVLNMRWADLENWDWFAGEEGIPVLPRQQLNGKYRIWMDEDVLQLIFVQYIGTRLCNMLKNKLKEFILSNSVWNWKVGPVLTEHDKERQKYYFESPRTYGTAFQHGPEKSRKKDYLERYFLCQMPLELTTLADGGAPYDDDNSDEDDNSDEGSENGWNSSHHDSSATADRNIKQQLLRKVATETLIQRYVYGEAAVIQSDLRWYATGLPHSTIFAVMRYVGFSENWIHFFRKYLESPLNMDMSFEGRMPTGPRTRRRGVPMAHSSEKLLGELVLFFMDLTVNRTTGLLLYRLHDDLWLCGEPSKCAQSWEAIRRFANVTGLEFNKNKTGSVYLSNSVDPAVQSRLPGGPVTFGFLKLDSSGVWVIDQGQVDAHVKQLKAQLDKCESVMAWIRTWNSCIGRFFKNTFGQPATCFGQGHVDMILSTYRAMQKTLFGESTATVTQHLRQMIQARFGVSDIPDAFFYYPEELGGLGLRNPSISPFLVRNSLQTSPQQHIDNFFSEERKLYDRLKKAFDETPQKARMTHFAQANDGMERRFVSRAERDTFMSFEELTRFRWSQSTIFRTLYQRLQDVPKPENIILISKVSQALYSALGMVKVRMMDQEKRWVLQMYAPEVLRDYGGMALVDKKYLPVGVMAMVKERRVKWQMVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="108" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ATC9</accession>
    <accession>C8VEG2</accession>
    <name>Q5ATC9_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Luciferase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ANIA_08451</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF80580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_681720.1">
        <property type="nucleotide sequence ID" value="XM_676628.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ATC9"/>
    <dbReference type="GeneID" id="2868743"/>
    <dbReference type="KEGG" id="ani:ANIA_08451"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN8451"/>
    <dbReference type="eggNOG" id="ENOG502S7YG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027853_1_1_1"/>
    <dbReference type="InParanoid" id="Q5ATC9"/>
    <dbReference type="OMA" id="ADYNFCF"/>
    <dbReference type="OrthoDB" id="2558704at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01094">
        <property type="entry name" value="Alkanesulfonate_monoxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="entry name" value="Luciferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
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        <property type="entry name" value="SsuD_RutA_monooxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42847">
        <property type="entry name" value="ALKANESULFONATE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42847:SF4">
        <property type="entry name" value="ALKANESULFONATE MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
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    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="Bacterial luciferase-like"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="51"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBF80580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="389" mass="43007" checksum="5A6C4AD5684B8AA5" modified="2005-04-26" version="1">MPTTSVREGGPTLKGPSDFPDSPLRVASRQPLMLGVFLDLQDRKLSSFPTSNSWTFDYNLEIVRKAEEAGFDIAFSRMQWLPKGGYDGEASLDAFIALGAMAAATSKILLISTIHVLYGPLHPLHIAKFGATLDHISKGRWGINIVTGHRAVEHQMFGWNRIEHDKRYEMAGELFDVVNSLWGETENLTYEGKVSPWKLENAWVTPKPLYGRPVLVNATGSPAGVDFAVRYSDLVFITSPAGADIQSALDSLPDHIAGIKNAAGNAHREIKVLINPVIVSRNTAEDTQAYLQSIVDGMGVDEKERRPFTKYDSDAHAWRGQNDFRKQGYNLGGNVEVIGTPEEVVEQLKALHSVGIDGVQLGFYDWKVDFDHFLEHILPLLKEGGLRIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AU83</accession>
    <accession>C8V6V5</accession>
    <name>Q5AU83_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_08147</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF73978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_681416.1">
        <property type="nucleotide sequence ID" value="XM_676324.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AU83"/>
    <dbReference type="GeneID" id="2869309"/>
    <dbReference type="KEGG" id="ani:ANIA_08147"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN8147"/>
    <dbReference type="eggNOG" id="ENOG502QS59">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025989_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AU83"/>
    <dbReference type="OMA" id="DAQFWES"/>
    <dbReference type="OrthoDB" id="1708389at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021709">
        <property type="entry name" value="DUF3292"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38694:SF2">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38694">
        <property type="entry name" value="CONSERVED EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11696">
        <property type="entry name" value="DUF3292"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="93"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="342"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF73978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="606" mass="66322" checksum="FF41CF626BBCFB26" modified="2005-04-26" version="1">MTQPEDPLTPGLSNNDLWRLIRRFDKQVSHVEAIPCTDSHQLDLNRAADEQFPASKLQKTIERFYVSVLVKVGLFISHVNHLRSWDDPRRTGVFGAVYLIAWLCDFIIPLLSSILLAMIFSPSIRSSLFPPIPESELQTQGQPSSREESTLHVHVPPVNEGEAEDEAADLVNGIKSSIQQDAQEAIGIPPGIDGLEPEVVVASDTASADEPGKAKTSPAIRITLCVISDITDLCERFSNLLSPTPPFSLIAPRLQLAAILMLIFLASLSVSSHLIVKTSSLAIGFGFFGDPVLSRAMDFLNTKIPNWKTYLDIEKTLLKGVPTDAQLTLTLLRIGELNSSPLPVPPRSDSASSPEQSPLKLFRRKSSKTVETGSDASDAVESNKSQTETGTVSSEGESTKKSKAKKWLRILKFARRAITTAIKGHVAYNRAMGLTGAGSRYYAKSLLSAALDRNLTFQHLSVLALGPPSSHHLHGGPFTFEAKFERKRGTAVLDFSDNEHPILYFTSKNAAKIQDDLRIDSQKGENVLFRVPVADIRELRKTEGLGWKGKLIVQLAAGGEGSTEGLVVLVKDEDGVERSYHLTGVRGRNVLFNRLVAGGGQCWEMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AUJ9</accession>
    <accession>C8V5U7</accession>
    <name>Q5AUJ9_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_08031</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF73739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_681300.1">
        <property type="nucleotide sequence ID" value="XM_676208.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AUJ9"/>
    <dbReference type="STRING" id="227321.Q5AUJ9"/>
    <dbReference type="GeneID" id="2869295"/>
    <dbReference type="KEGG" id="ani:ANIA_08031"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN8031"/>
    <dbReference type="eggNOG" id="ENOG502S3MD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012320_2_0_1"/>
    <dbReference type="InParanoid" id="Q5AUJ9"/>
    <dbReference type="OMA" id="QTWRSWY"/>
    <dbReference type="OrthoDB" id="6235964at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38700:SF1">
        <property type="entry name" value="PH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38700">
        <property type="entry name" value="YALI0E22418P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="531"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="620"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="814"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="558"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="626"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="755"/>
            <end position="768"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF73739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="853" mass="92761" checksum="6EC1121DC6B2BCF5" modified="2005-04-26" version="1">MTTDAQELAGVGAQGPTPAKFSRYRSVRKAASTNAQVMAPLNTAIPPVPTRQSTPATASQEHTEIASAQPASIKKSMSRYRRQKPPTPSSTDAVPLPMTAEHGGPRTQHATAVYDDYPSRHPHQYPQRMEATKPRSKFTDAVRLDTRGNGFFGGNGSASSDAELDERERDRQAAMAKLTGGCVESPATPLAHQRPATRGRAATDREVNQGSNNLNHYDSAESRRHSHHEPKRKSFRDAMKFPRAKDKTRNGSPAKGGGESTAPGQFPGIDAPVSAVNAGERRVLVQYKKDNLKLSVSPSTSAYDILVSASGRISEIDPPRFILMESFTAQGLERPLRQYECIREVMNSWAHDAENTLIIVPAPSVHALDFLAAQNVPKDPPMDATFHIYYSQKPRKWDKRYVTIRSDGQIVSSKKEMAKEQTNVCHLSDFDIYSPKSSFLAQKVKPPKKICYAVKSQQKASMFLTTENFIHFFSTNDKTIADGWYKAVQNWRSWYLVNKLGAGQIENNAEPAQTEPAQFRSIQPLLASIDTAEQETSTERPQARQTSLRRGPSREHGPPLSSLPKSLTSTTETETSTTQTQSSGESPFSASGLLGRTYTLRQKAMKEREDREKREAEVLFQHGLIGSNTATATSAPRQRSQPGSRTNSITSAQAQSQHTDSESLLRRSQSVKQGGQKPKPLVDLTPVYQEPPQHARKGRGVAVDTGGPLIDAATGPSNELAGGIVIPPAKTWRRPTLTGNGPGVPSPPQEPQSSTEAQARTRNRSNTARSHRHGHYNAATTTPVTPTSPPDLGSPQDQVSAFAPNSLLARTGLASTGVPVGHGVATGDRNATKPMLDVSPQSPFAEGSLLRGL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2018-05-23" modified="2026-01-28" version="117" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AUZ9</accession>
    <accession>A0A1U8QUH5</accession>
    <accession>C8V3Y6</accession>
    <name>ATNE_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cytochrome P450 monooxygenase atnE</fullName>
            <ecNumber evidence="9">1.-.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Aspercryptin biosynthesis cluster protein E</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">atnE</name>
        <name type="ORF">ANIA_07881</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="E99" last="E107">
            <title>Accurate prediction of secondary metabolite gene clusters in filamentous fungi.</title>
            <authorList>
                <person name="Andersen M.R."/>
                <person name="Nielsen J.B."/>
                <person name="Klitgaard A."/>
                <person name="Petersen L.M."/>
                <person name="Zachariasen M."/>
                <person name="Hansen T.J."/>
                <person name="Blicher L.H."/>
                <person name="Gotfredsen C.H."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Mortensen U.H."/>
            </authorList>
            <dbReference type="PubMed" id="23248299"/>
            <dbReference type="DOI" id="10.1073/pnas.1205532110"/>
        </citation>
        <scope>IDENTIFICATION OF THE CLUSTER</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2016" name="ACS Chem. Biol." volume="11" first="2117" last="2123">
            <title>New aspercryptins, lipopeptide natural products, revealed by HDAC inhibition in Aspergillus nidulans.</title>
            <authorList>
                <person name="Henke M.T."/>
                <person name="Soukup A.A."/>
                <person name="Goering A.W."/>
                <person name="McClure R.A."/>
                <person name="Thomson R.J."/>
                <person name="Keller N.P."/>
                <person name="Kelleher N.L."/>
            </authorList>
            <dbReference type="PubMed" id="27310134"/>
            <dbReference type="DOI" id="10.1021/acschembio.6b00398"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2016" name="Angew. Chem. Int. Ed." volume="55" first="1662" last="1665">
            <title>Development of genetic dereplication strains in Aspergillus nidulans results in the discovery of aspercryptin.</title>
            <authorList>
                <person name="Chiang Y.M."/>
                <person name="Ahuja M."/>
                <person name="Oakley C.E."/>
                <person name="Entwistle R."/>
                <person name="Asokan A."/>
                <person name="Zutz C."/>
                <person name="Wang C.C."/>
                <person name="Oakley B.R."/>
            </authorList>
            <dbReference type="PubMed" id="26563584"/>
            <dbReference type="DOI" id="10.1002/anie.201507097"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>PATHWAY</scope>
    </reference>
    <comment type="function">
        <text evidence="4 5 6">Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of aspercryptins, linear lipopeptides built from six amino acids including 2 highly unusual and nonproteogenic amino acids, 2-amino-octanoic acid (2aoa) and 2-amino-dodecanol (2adol) (PubMed:23248299, PubMed:26563584, PubMed:27310134). The core structure of aspercryptins is as follows: Ser/Ala-Thr-Ile/Val-2aoa-Asn-2adol (PubMed:27310134). The first step of aspercryptin biosynthesis is the generation of the fatty acid precursors, octanoic and dodecanoic acids, by the FAS subunits atnF and atnM (PubMed:26563584, PubMed:27310134). The fatty acid precursors are likely transformed into the corresponding alpha-amino fatty acids in three steps (PubMed:26563584, PubMed:27310134). First, they are hydroxylated by the cytochrome P450 monooxygenase atnE, then oxidized to the corresponding alpha-keto acids by the NAD(P)-dependent oxidoreductase atnD, and finally converted to the alpha-amino fatty acids by the PLP-dependent aminotransferases atnH or atnJ (PubMed:26563584, PubMed:27310134). the alpha-amino fatty acids, 2-amino-octanoic and 2-amino-dodecanoic acids, are recognized, activated, and covalently tethered to the NRPS atnA by its fourth and sixth adenylation domains (PubMed:27310134). The second module of atnA is the Thr module and contains an epimerase (E) domain responsible for the epimerization of Thr to D-allo-Thr (PubMed:26563584). Additionally, despite atnA having only one epimerase domain, the first amino acid of aspercryptin A1 is D-Ser, suggesting that serine is either loaded directly as D-Ser on the first module or that the epimerase domain in the threonine module epimerizes both L-Ser and L-Thr (PubMed:27310134). After condensation of the hexapeptide of aspercryptin, the C-terminal reductase (TE) domain might be involved in the reductive release and production of the aldehyde hexapeptide (PubMed:26563584). Further reduction would generate aspercryptins (PubMed:26563584, PubMed:27310134). The variety of aspercryptins produced reflects the flexibility of the atnA NRPS, allowing incorporation of alanine instead of serine, valine for isoleucine, and a C10 fatty amino alcohol instead of the C12 version (PubMed:27310134). AtnB seems to be involved in the selectivity for Ile versus Val by the third module (PubMed:26563584). Moreover, type B, C and D aspercryptins have an additional N-terminal cichorine, acetyl and propionyl group respectively (PubMed:27310134).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="6">Expression is positively regulated by the aspercryptin cluser-specific transcription factor atnN (PubMed:27310134).</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="5">Abolishes the production of aspercryptin (PubMed:26563584).</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="9"/>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF73446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AACD01000135">
        <property type="protein sequence ID" value="EAA59535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_681150.1">
        <property type="nucleotide sequence ID" value="XM_676058.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AUZ9"/>
    <dbReference type="SMR" id="Q5AUZ9"/>
    <dbReference type="STRING" id="227321.Q5AUZ9"/>
    <dbReference type="GlyCosmos" id="Q5AUZ9">
        <property type="glycosylation" value="1 site, No reported glycans"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CBF73446">
        <property type="protein sequence ID" value="CBF73446"/>
        <property type="gene ID" value="ANIA_07881"/>
    </dbReference>
    <dbReference type="GeneID" id="2869072"/>
    <dbReference type="KEGG" id="ani:ANIA_07881"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN7881"/>
    <dbReference type="eggNOG" id="KOG0157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_14_11_1"/>
    <dbReference type="InParanoid" id="Q5AUZ9"/>
    <dbReference type="OMA" id="HILWRFD"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902181">
        <property type="term" value="P:verruculogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11061">
        <property type="entry name" value="CYP67-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000063">
        <property type="entry name" value="Cytochrome P450 monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF237">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ATNE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0349">Heme</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0503">Monooxygenase</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000444123" description="Cytochrome P450 monooxygenase atnE">
        <location>
            <begin position="1"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="11"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="1">
        <location>
            <position position="458"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P04798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="23248299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="26563584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="6">
        <source>
            <dbReference type="PubMed" id="27310134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="7">
        <source>
            <dbReference type="PubMed" id="26563584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="8"/>
    <evidence type="ECO:0000305" key="9">
        <source>
            <dbReference type="PubMed" id="26563584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBF73446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="518" mass="58116" checksum="224FCBF4AD633C88" modified="2005-04-26" version="1">MLPTYFGTSNFLAAFAVWMGVVVLAFAIFCVRRLYFHPYSKYPGPLLGKLTNYYAVYHSWKGDQHIDMWRCHEKYGPYVRYGPNELSINTAAGLKEIYSHGRNFKKSVKYNAMVHQAANTLTTIDKRKHGKKRRLISQAFSDAAFRSYEETIQQKIAQLCTALRRRDDDSNEIVPDGNWGPAKNMSHWCDWFTFDVMCSVIFGVPWSSLTEKTYRNVPHLIEVSNVRVGCLIEAGGSKNMKIDKYLFPAAIAARNQFVKFVNDIIRQGMAMSAKGSLKGAFALLRDATDPETQEPLSFKELCGESATLVVAGTDTTSTALAASIYYLCNHPKVYERAVQEVRSTFQSRAEIGLGPKVNSCTYLRAVIEESMRLSPSAPGPLWRQADAGGATVDGQYIPQGLEAGTCVYAIQHHPEIYPQPFKFVPERWLGPEAVPEQYRSDYSPFAGFTPFSIGPRGCIGKPLAYIELTLTLCHILYAFDMRLPQGVNVNEDAEYQLALHITAAKEGPLVEFRPRTVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AVQ8</accession>
    <accession>C8VBW9</accession>
    <name>Q5AVQ8_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ATP-grasp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_07622</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF79762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_680891.1">
        <property type="nucleotide sequence ID" value="XM_675799.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AVQ8"/>
    <dbReference type="GeneID" id="2869585"/>
    <dbReference type="KEGG" id="ani:ANIA_07622"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN7622"/>
    <dbReference type="eggNOG" id="ENOG502RZZG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026180_1_0_1"/>
    <dbReference type="InParanoid" id="Q5AVQ8"/>
    <dbReference type="OMA" id="HIAGCTQ"/>
    <dbReference type="OrthoDB" id="186626at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF79762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="494" mass="55862" checksum="E57D193268FD27B4" modified="2005-04-26" version="1">MVAFGLRRLNATSRRQIYLMARRLSRRQVLGHLLRVIVSLLFLLPNNLILSVALSVRCLSWFFPCSALRRRQGILQDVRFRPKTVLITGLDTPHGLHIARCWYSEGHRVVGADVAEARFASGGSLSKALVAHYRLSKSQYVSRLLDIVLREKVDIWIPCAQDASAVEDGMAKQAIESRTSCRCVTLDPELASQWSRSESFVQYLIDHGHPIVETHEVHSRDSIHKILHRSPTKVYHLRKTTPVANTETIIVLPKKTLSSTYSEVSRIQVTKDSPWIMQQHVRLGEFIADVLTIRGHVAVLVLRSASRGSEWGSSRLNEGIAAAAHQVVDKFASEGGSRVTGHFQMRLVVDEQLHLNSVRYEVYIAGCTQGAATIADLLQQTPAHTLVDRYLAVLEDALKTSENGFTHPEVGPKMLSRPSTVYQAITNHDARKALTALNQIAKQINWTLDRAGKFMLFWANWRFSIIDPLPWWWHIHVYRPLTELELMLGFSKRA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-04-03" modified="2025-06-18" version="124" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AW32</accession>
    <accession>C8VBH9</accession>
    <name>DOHH_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Deoxyhypusine hydroxylase</fullName>
            <shortName evidence="1">DOHH</shortName>
            <ecNumber evidence="1">1.14.99.29</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Deoxyhypusine dioxygenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Deoxyhypusine monooxygenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">lia1</name>
        <name type="ORF">AN7498</name>
    </gene>
    <organism>
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[eIF5A protein]-deoxyhypusine + AH2 + O2 = [eIF5A protein]-hypusine + A + H2O</text>
            <dbReference type="Rhea" id="RHEA:14101"/>
            <dbReference type="Rhea" id="RHEA-COMP:10144"/>
            <dbReference type="Rhea" id="RHEA-COMP:12592"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:82657"/>
            <dbReference type="ChEBI" id="CHEBI:91175"/>
            <dbReference type="EC" id="1.14.99.29"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="1">Binds 2 Fe(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; eIF5A hypusination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the deoxyhypusine hydroxylase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.29" evidence="1"/>
    <dbReference type="EMBL" id="AACD01000129">
        <property type="protein sequence ID" value="EAA62078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF79503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_680767.1">
        <property type="nucleotide sequence ID" value="XM_675675.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AW32"/>
    <dbReference type="SMR" id="Q5AW32"/>
    <dbReference type="FunCoup" id="Q5AW32">
        <property type="interactions" value="891"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5AW32"/>
    <dbReference type="EnsemblFungi" id="CBF79503">
        <property type="protein sequence ID" value="CBF79503"/>
        <property type="gene ID" value="ANIA_07498"/>
    </dbReference>
    <dbReference type="KEGG" id="ani:ANIA_07498"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN7498"/>
    <dbReference type="eggNOG" id="KOG0567">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053974_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AW32"/>
    <dbReference type="OMA" id="LQEPCSI"/>
    <dbReference type="OrthoDB" id="421002at2759"/>
    <dbReference type="UniPathway" id="UPA00354"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019135">
        <property type="term" value="F:deoxyhypusine monooxygenase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03101">
        <property type="entry name" value="Deoxyhypusine_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027517">
        <property type="entry name" value="Deoxyhypusine_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004155">
        <property type="entry name" value="PBS_lyase_HEAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12697:SF5">
        <property type="entry name" value="DEOXYHYPUSINE HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12697">
        <property type="entry name" value="PBS LYASE HEAT-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13646">
        <property type="entry name" value="HEAT_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00567">
        <property type="entry name" value="EZ_HEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0386">Hypusine biosynthesis</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0503">Monooxygenase</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <feature type="chain" id="PRO_0000283664" description="Deoxyhypusine hydroxylase">
        <location>
            <begin position="1"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT-like PBS-type 1">
        <location>
            <begin position="68"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT-like PBS-type 2">
        <location>
            <begin position="101"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT-like PBS-type 3">
        <location>
            <begin position="235"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT-like PBS-type 4">
        <location>
            <begin position="268"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="336" mass="36666" checksum="0C87ABFBA33A647B" modified="2005-04-26" version="1">MTTDNLNSADTTVQTLRNVLTSETEPLARRFRALFSLKHLACLQPPTEKTLPAIQAIAAGFSSASALLKHELAYCLGQTRNTDALPFLLDVVQDTQEDSMCRHEAAEALGALGYESSLEVLKALRDNENEVDVVRETCDIAVDRILWEQSEARKAEKLKPSDFTSIDPAPPMPLTAKEPSIPDLEKTLLDTNLPLFERYRAMFGLRDLASPPDLPTAKQAVQSLAKGMKDPSALFRHEIAFVFGQLCHPASVPSLTETLSDLNEVGMVRHEAAEALGSLGDVEGVEDTLKKFLNDPEKVVRDSIIVALDMAEFEKNGEIEYALIPDSGNPAAVPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AW73</accession>
    <accession>C8VBD3</accession>
    <name>Q5AW73_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Vacuolar membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ANIA_07457</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF79419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_680726.1">
        <property type="nucleotide sequence ID" value="XM_675634.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AW73"/>
    <dbReference type="FunCoup" id="Q5AW73">
        <property type="interactions" value="59"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5AW73"/>
    <dbReference type="TCDB" id="8.A.65.1.3">
        <property type="family name" value="the endoplasmic reticulum (er)-plasma membrane (pm) junctional competence regulator (tmem110) family"/>
    </dbReference>
    <dbReference type="GeneID" id="2869541"/>
    <dbReference type="KEGG" id="ani:ANIA_07457"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN7457"/>
    <dbReference type="eggNOG" id="ENOG502S1HE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040321_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AW73"/>
    <dbReference type="OMA" id="MLVIWAA"/>
    <dbReference type="OrthoDB" id="431202at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022127">
        <property type="entry name" value="STIMATE/YPL162C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31735">
        <property type="entry name" value="VACUOLAR MEMBRANE PROTEIN YPL162C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31735:SF1">
        <property type="entry name" value="VACUOLAR MEMBRANE PROTEIN YPL162C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12400">
        <property type="entry name" value="STIMATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
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        <location>
            <begin position="18"/>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="108"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="142"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="202"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="240"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="332"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="33"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="342"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBF79419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="370" mass="40640" checksum="FF0469BD1D6DD349" modified="2005-04-26" version="1">MAYASIPLFSAAILVSALDIGVNALVSPTGVITTPSPSLSTPAASYSPTSSSSSGHDEDNGECRLLGPFSLVVQAALGMLALLSLVYKRWRERPQRPVKVWAFDASKQVFGSSMLHLFNLLMSMFSAGQFEITSKYKPNPCSFYLLNLGIDTTLGIPILIVILHVLNRLAKYTPLANPPESIESGNYDDPPRVSWWFKQSMIYFLGLLGMKICVFFLIQMVPLIVKVGDWALRWTEGNTAIQIIFVMLIFPVIMNAIQYYIIDIFIKKPLSVSHDLESADTASDNDADDRHALLAGLEDDDTFDRDGSLGSDERTLHSPVQFKEALDHLNAAKRDPVGSLDSASTPTSSSARENDDTTLSTEINVQPKDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AWB8</accession>
    <accession>C8VCD0</accession>
    <name>Q5AWB8_EMENI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_07412</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF78429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_680681.1">
        <property type="nucleotide sequence ID" value="XM_675589.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AWB8"/>
    <dbReference type="GeneID" id="2869803"/>
    <dbReference type="KEGG" id="ani:ANIA_07412"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN7412"/>
    <dbReference type="eggNOG" id="ENOG502SVRF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_168472_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AWB8"/>
    <dbReference type="OMA" id="KACAAYK"/>
    <dbReference type="OrthoDB" id="3489571at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010342999" evidence="1">
        <location>
            <begin position="19"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF78429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="104" mass="11350" checksum="8A633307A43C8E3B" modified="2005-04-26" version="1">MIASIPLVIAALATTAFADLHIQGVCIDTPGSGVEVYNRVATEKACEAYKKRNTGSNQWDQCPDCVLKSERDLLYYCESQGQHIGGDELNYYCKQNGAGDSVAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="119" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AWG9</accession>
    <accession>C8VCI9</accession>
    <name>Q5AWG9_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Glutamyl-tRNA synthetase (AFU_orthologue AFUA_2G16280)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ANIA_07361</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF78544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_680630.1">
        <property type="nucleotide sequence ID" value="XM_675538.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AWG9"/>
    <dbReference type="FunCoup" id="Q5AWG9">
        <property type="interactions" value="694"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5AWG9"/>
    <dbReference type="GeneID" id="2869795"/>
    <dbReference type="KEGG" id="ani:ANIA_07361"/>
    <dbReference type="eggNOG" id="KOG1149">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015768_7_1_1"/>
    <dbReference type="InParanoid" id="Q5AWG9"/>
    <dbReference type="OMA" id="YHYLRWA"/>
    <dbReference type="OrthoDB" id="428822at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004818">
        <property type="term" value="F:glutamate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006424">
        <property type="term" value="P:glutamyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045462">
        <property type="entry name" value="aa-tRNA-synth_I_cd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020751">
        <property type="entry name" value="aa-tRNA-synth_I_codon-bd_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008925">
        <property type="entry name" value="aa_tRNA-synth_I_cd-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049940">
        <property type="entry name" value="GluQ/Sye"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43311">
        <property type="entry name" value="GLUTAMATE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43311:SF2">
        <property type="entry name" value="GLUTAMATE--TRNA LIGASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19269">
        <property type="entry name" value="Anticodon_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48163">
        <property type="entry name" value="An anticodon-binding domain of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic" evidence="9">
        <location>
            <begin position="14"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class I anticodon-binding" evidence="10">
        <location>
            <begin position="361"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="454"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="473"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF19269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CBF78544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="495" mass="55915" checksum="E7D102B3FC5231D8" modified="2005-04-26" version="1">MLRSALAGPTLMELQSERTEIHRKYAEKLIQRGHAYRCFCSPERLDAHARHRSQAGLPPGYDRKCASLLPAHSEERAALGESHVIRLRVEDHPYRYPVYDDLVYGETGHKGPPTKLDLIDRVYDDPILIKSDGYPTYHLANVVDDHLMEITHVIRGTEWMSSTPLHVLLYKCFGWKAPRFAHVPLLVDHSGQKLSKRNADIDLSHFRDQGVFPEPLLNFAALLGWSHKEKNDIFDLKKLEHRFTLKFTRGNTTVAFEKLWFLQSAHVKRYVDGNMPQVNEMISAVAKVVQSTASPEQLSQILQSRPLVDMITPLIKADAKNYTNPKEFVARNSTFFTTDISRPPYDRAVIQFVIPFSSLHTAAAAVTLIPKSHWTLETLRENFATYDAASAVPEEVMTVDAEKKFKKELYHYLRWALSAGASGPTVPEIMIILGREETLKRLEEARKLTTEDGAVSPVAARLMKEKGLEPKTGSANKAQTKGHSWTPHPSLPSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="122" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AWM6</accession>
    <accession>C8VCQ1</accession>
    <name>Q5AWM6_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial thiamine pyrophosphate carrier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">ANIA_07304</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="16">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF78658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_680573.1">
        <property type="nucleotide sequence ID" value="XM_675481.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AWM6"/>
    <dbReference type="FunCoup" id="Q5AWM6">
        <property type="interactions" value="225"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5AWM6"/>
    <dbReference type="GeneID" id="2870176"/>
    <dbReference type="KEGG" id="ani:ANIA_07304"/>
    <dbReference type="eggNOG" id="KOG0752">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_10_0_1"/>
    <dbReference type="InParanoid" id="Q5AWM6"/>
    <dbReference type="OMA" id="VYERMKW"/>
    <dbReference type="OrthoDB" id="270584at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015228">
        <property type="term" value="F:coenzyme A transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990559">
        <property type="term" value="P:mitochondrial coenzyme A transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24089">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="401"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="92"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="189"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="342"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="12"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CBF78658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="433" mass="46717" checksum="3EF4FF84D9833FBC" modified="2005-04-26" version="1">MSAAATGHAQDDSTSLIPNPTSPNIIGDSQSRNQSASQQMESASHAQRPTSHNISSGAVVAGPHATTADDPSHRPGQSSRNGGQEKNKRSLDYVLRSGLAGGLAGCATVVAPLDRVKILFQASNPQFAKYTGSWTGLVFAIRDIKRHEGARGLYRGHSATLLRIFPYASIKFLAYEQFRAIVIPSRDKETPFRRLVSGSLAGITSVFFTYPLELIRVRLAFETKKSSRSSLVDTIRQIYGEQVKPPKELSTGKGTSSVTGTAAAAANTVSSTTRNIVPSSGLANFYRGFTPTLLGMIPYAGVSFLTHDTVGDWLRLPLLAPYTTIPRSSSSGHKKDRQKLQLTAAAELLSGAIAGLVSQTSSYPLEVVRRRMQVGGVVGDGRRLGMAETARIIMMERGFRGFFIGLTIGYLKMIPMTATGFFVYERLKWSLGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="101" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AXQ2</accession>
    <accession>C8V359</accession>
    <name>Q5AXQ2_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ANIA_06928</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF71760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_664532.1">
        <property type="nucleotide sequence ID" value="XM_659440.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AXQ2"/>
    <dbReference type="GeneID" id="2870637"/>
    <dbReference type="KEGG" id="ani:ANIA_06928"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_13_0_1"/>
    <dbReference type="InParanoid" id="Q5AXQ2"/>
    <dbReference type="OMA" id="YALDCHK"/>
    <dbReference type="OrthoDB" id="4500315at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF4">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="72"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="109"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="168"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="198"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="314"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="352"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="395"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="422"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="477"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="73"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBF71760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="511" mass="55486" checksum="2A3EDD3CFB05F60D" modified="2005-04-26" version="1">MDIKGQIKVLEQDVSHTPGTQVWFSSVQTGTRWSLFQRTSDVELIPAPAPTVTNNSSSPNDPLNWPSWRRGALLYAVGINSFLAAALAPILATGFPSISSSFGVDLQKVSFTIGIYMLGLGFGALIGSPTAMLFGRRLVYVSGSALLIVSSAWAAASPSYTSIILARFVQGFAAAPGEFLVSVSISEIYTPQERGFRLGIYMLLLAGGKSLSPLIGAGVIQRLGWRWVLWILTIASGACFTCLFLFARETYWARDYKEDAITPQMPGELYTENLRISPPLRFSHTLSIWNGRLSSAGWVSLTLRPLALLNSPPLLWSATVYALSLGWLAVLAETIAHLFQSVGGYGFTPIQAGLLYLSPLIGTILGSVIGGKVSDILAKVKAYRNNGVYEPESRLLMMIPAILVSTLGLAGYGWSIQLRTHWFIPTLCFGAIYFGCILGSTIAVTYCLDCHKADAIGTQVVLSLMKNWVKACGPRNTFLIIAGIHSAFLSATIFMYIHGKQFRIRMGKRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="127" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AXW7</accession>
    <accession>C8V2P0</accession>
    <name>Q5AXW7_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">uncB</name>
        <name evidence="8" type="ORF">ANIA_06863</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF71617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_659375.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AXW7"/>
    <dbReference type="STRING" id="227321.Q5AXW7"/>
    <dbReference type="GeneID" id="2870565"/>
    <dbReference type="KEGG" id="ani:ANIA_06863"/>
    <dbReference type="eggNOG" id="KOG0245">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001485_2_3_1"/>
    <dbReference type="InParanoid" id="Q5AXW7"/>
    <dbReference type="OMA" id="SFWSHNT"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005871">
        <property type="term" value="C:kinesin complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047496">
        <property type="term" value="P:vesicle transport along microtubule"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd01365">
        <property type="entry name" value="KISc_KIF1A_KIF1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000050">
        <property type="entry name" value="Kinesin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47117">
        <property type="entry name" value="STAR-RELATED LIPID TRANSFER PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="3 4" id="KW-0505">Motor protein</keyword>
    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="7">
        <location>
            <begin position="106"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="39"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="584"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="645"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="485"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="44"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="74"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="599"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="645"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="212"/>
            <end position="219"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBF71617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="670" mass="75389" checksum="FB3A1455FE2D77D3" modified="2005-04-26" version="1">MYHHFIRRQREIVAQLEQTLSDHGEEMALDPRFYHHLGPGIGSGSQSSASLSGLSSATGITSPSIQSSAASSAGLRSTASSPSLRSRQGVVARPSDGVPGLGPGGNVRVVVRVRKFLPRELERKAPCLISMDPDTQTTRLKAPSSHYDEGKPKSQARGKVLDDKEFVFDNSFWSHNEADEHYAHQEDIYNCLGEEFLDHNFEGYHTCIFAYGQTGSGKSYTMMGTPEQPGLIPRTCEDLFQRIEHAESPDVSYNVRVSYFEVYNEHVRDLLVPRTDPPHYLRIRESPTEGPYVKDLTEVTVRNYAEIMKYMRKGDISRTVASTKMNDTSSRSHAVFTITLKQIHHDLSTDETTERTARIRLVDLAGSERAKSTEATGQRLREGSNINKSLTTLGRVIAALADPKAGRTGKRKGKEVVPYRDSILTWLLKDSLGGNSKTAMIACISPTDYEETLSTLRYADQAKHIRTRARVNQDHLSAAERDRQIEEMAETIRTLQLSVSQAAQNRRETEVQNERLEEYQQQVEKLQRLMEENKMVSECKIRQLQTENEALRNHLKLALDSLKNPIPPVTIEKALSDVDIPDEEQPIDEQQPGSPTSEAETEPDLIWEDENLPPDTSELEAQEMQATMENLLGDLDVFKRKLATDHERFGASRKHEGRKRRRALGDILGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AY04</accession>
    <accession>C8V2G6</accession>
    <name>Q5AY04_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Microfibrillar-associated protein MfaP1, putative (AFU_orthologue AFUA_5G12890)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_06826</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF71539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_664430.1">
        <property type="nucleotide sequence ID" value="XM_659338.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AY04"/>
    <dbReference type="STRING" id="227321.Q5AY04"/>
    <dbReference type="GeneID" id="2870502"/>
    <dbReference type="KEGG" id="ani:ANIA_06826"/>
    <dbReference type="eggNOG" id="KOG1425">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022379_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AY04"/>
    <dbReference type="OMA" id="FHNERAG"/>
    <dbReference type="OrthoDB" id="1111734at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033194">
        <property type="entry name" value="MFAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009730">
        <property type="entry name" value="MFAP1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15327">
        <property type="entry name" value="MICROFIBRIL-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06991">
        <property type="entry name" value="MFAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Micro-fibrillar-associated protein 1 C-terminal" evidence="2">
        <location>
            <begin position="145"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF71539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="439" mass="50052" checksum="FA71ABED8D1B1417" modified="2005-04-26" version="1">MPPPFPTSHRGMTANPQRPARYRPGKPIAEEPSSEEEEEEEVNEEIQGEQERKRLEQQRQKQAAPKATSFPGTRTVTKDIKDVKVQQEDDDDEEGFVTEEEDEGVAIARDIVAAQVAKPAEKEQEEEEEEEEESEEEESSDEESSSEDEAPRRVLLRPTFIKKDKRTNGATDHQGAAAADSIAEAEARKAQRQEKADALVREQIEKDAIARSSANKAWDDDEAMANEEAAIDDTDGKDPEAEYAAWKLRELKRIKREREAIEAAEKEREEVERRRNLTAEEREREDQEFLAKQKEEREASRGQTGYMQRYFHKGAFFRPDLEKEGLDKRNVMGARFADDVARETLPQYMQIRDMTKLGKKGRTRYKDLRTEDTGRFGEGFGNRRRQEAPVGVTDERFLPDRGFDKKGPTGANASVWTTLVRLKSIGSLACSLLILIYAG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2020-04-22" modified="2026-01-28" version="129" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AYI7</accession>
    <accession>A0A1U8QYB2</accession>
    <accession>C8V1C9</accession>
    <name>BIOB_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Biotin synthase, mitochondrial</fullName>
            <ecNumber evidence="8">2.8.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">bioB</name>
        <name type="ORF">ANIA_06643</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2011" name="Fungal Genet. Biol." volume="48" first="208" last="215">
            <title>Characterization of the Aspergillus nidulans biotin biosynthetic gene cluster and use of the bioDA gene as a new transformation marker.</title>
            <authorList>
                <person name="Magliano P."/>
                <person name="Flipphi M."/>
                <person name="Sanglard D."/>
                <person name="Poirier Y."/>
            </authorList>
            <dbReference type="PubMed" id="20713166"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2010.08.004"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INDUCTION</scope>
        <scope>PATHWAY</scope>
    </reference>
    <comment type="function">
        <text evidence="1 5">Biotin synthase; part of the cluster involved in the biosynthesis of biotin (also known as vitamin B8 or vitamin H), a water-soluble vitamin that functions as a prosthetic group of many carboxylases, such as acetyl-CoA carboxylase and pyruvate carboxylase (PubMed:20713166). Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(4R,5S)-dethiobiotin + (sulfur carrier)-SH + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = (sulfur carrier)-H + biotin + 2 5'-deoxyadenosine + 2 L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:22060"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="ChEBI" id="CHEBI:149473"/>
            <dbReference type="EC" id="2.8.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="1">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
        <text evidence="1">Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8">Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="5">Expression is increased when transferring biotin auxotrophic mutant mycelia from biotin-supplemented medium to biotin-deficient medium.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the radical SAM superfamily. Biotin synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.6" evidence="8"/>
    <dbReference type="EMBL" id="AACD01000110">
        <property type="protein sequence ID" value="EAA58172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF71159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_664247.1">
        <property type="nucleotide sequence ID" value="XM_659155.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AYI7"/>
    <dbReference type="SMR" id="Q5AYI7"/>
    <dbReference type="FunCoup" id="Q5AYI7">
        <property type="interactions" value="203"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5AYI7"/>
    <dbReference type="EnsemblFungi" id="CBF71159">
        <property type="protein sequence ID" value="CBF71159"/>
        <property type="gene ID" value="ANIA_06643"/>
    </dbReference>
    <dbReference type="GeneID" id="2870394"/>
    <dbReference type="KEGG" id="ani:ANIA_06643"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN6643"/>
    <dbReference type="eggNOG" id="KOG2900">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033172_1_2_1"/>
    <dbReference type="InParanoid" id="Q5AYI7"/>
    <dbReference type="OMA" id="NICTTHT"/>
    <dbReference type="OrthoDB" id="2414104at2759"/>
    <dbReference type="UniPathway" id="UPA00078">
        <property type="reaction ID" value="UER00162"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004076">
        <property type="term" value="F:biotin synthase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000011">
        <property type="entry name" value="Biotin synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01694">
        <property type="entry name" value="BioB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010722">
        <property type="entry name" value="BATS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002684">
        <property type="entry name" value="Biotin_synth/BioAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024177">
        <property type="entry name" value="Biotin_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00433">
        <property type="entry name" value="bioB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22976">
        <property type="entry name" value="BIOTIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22976:SF2">
        <property type="entry name" value="BIOTIN SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06968">
        <property type="entry name" value="BATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001619">
        <property type="entry name" value="Biotin_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01060">
        <property type="entry name" value="BATS_domain_containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00272">
        <property type="entry name" value="biotin_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01278">
        <property type="entry name" value="biotin_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00876">
        <property type="entry name" value="BATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-0001">2Fe-2S</keyword>
    <keyword id="KW-0004">4Fe-4S</keyword>
    <keyword id="KW-0093">Biotin biosynthesis</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0411">Iron-sulfur</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0809">Transit peptide</keyword>
    <feature type="transit peptide" description="Mitochondrion" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000449413" description="Biotin synthase, mitochondrial">
        <location>
            <begin position="21"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="3">
        <location>
            <begin position="81"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="366"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P12996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="20713166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="6">
        <source>
            <dbReference type="PubMed" id="20713166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="7"/>
    <evidence type="ECO:0000305" key="8">
        <source>
            <dbReference type="PubMed" id="20713166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBF71159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="393" mass="42979" checksum="68FA920C26B69BB5" modified="2005-04-26" version="1" precursor="true">MSVSFTRSFPRAFIRSYGTVQSSPTAASFASRIPPALQEAVAATAPRTNWTRDEVQQIYETPLNQLTYAAAAVHRRFHDPSAIQMCTLMNIKTGGCSEDCSYCAQSSRYSTGLKATKMSPVDDVLEKARIAKANGSTRFCMGAAWRDMRGRKTSLKNVKQMVSGVREMGMEVCVTLGMIDADQAKELKDAGLTAYNHNLDTSREFYPTIITTRSYDERLKTLSHVRDAGINVCSGGILGLGEADSDRIGLIHTVSSLPSHPESFPVNALVPIKGTPLGDRKMISFDKLLRTVATARIVLPATIVRLAAGRISLTEEQQVACFMAGANAVFTGEKMLTTDCNGWDEDRAMFDRWGFYPMRSFEKETNAATPQQHVDSVAHESEKNPAAPAAEAL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2010-10-05" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AYR9</accession>
    <accession>C8V0U4</accession>
    <name>RRP36_EMENI</name>
    <protein>
        <recommendedName>
            <fullName>rRNA biogenesis protein rrp36</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Ribosomal RNA-processing protein 36</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">rrp36</name>
        <name type="ORF">AN6561</name>
    </gene>
    <organism>
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the 90S pre-ribosome involved in the maturation of rRNAs. Required for early cleavages of the pre-RNAs in the 40S ribosomal subunit maturation pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Associates with 90S and pre-40S pre-ribosomal particles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RRP36 family.</text>
    </comment>
    <dbReference type="EMBL" id="AACD01000109">
        <property type="protein sequence ID" value="EAA57901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF70989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_664165.1">
        <property type="nucleotide sequence ID" value="XM_659073.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AYR9"/>
    <dbReference type="SMR" id="Q5AYR9"/>
    <dbReference type="FunCoup" id="Q5AYR9">
        <property type="interactions" value="530"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5AYR9"/>
    <dbReference type="EnsemblFungi" id="CBF70989">
        <property type="protein sequence ID" value="CBF70989"/>
        <property type="gene ID" value="ANIA_06561"/>
    </dbReference>
    <dbReference type="GeneID" id="2870329"/>
    <dbReference type="KEGG" id="ani:ANIA_06561"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN6561"/>
    <dbReference type="eggNOG" id="KOG3190">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048802_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AYR9"/>
    <dbReference type="OMA" id="ERKEMPW"/>
    <dbReference type="OrthoDB" id="448446at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009292">
        <property type="entry name" value="RRP36"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21738">
        <property type="entry name" value="RIBOSOMAL RNA PROCESSING PROTEIN 36 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21738:SF0">
        <property type="entry name" value="RIBOSOMAL RNA PROCESSING PROTEIN 36 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06102">
        <property type="entry name" value="RRP36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0690">Ribosome biogenesis</keyword>
    <keyword id="KW-0698">rRNA processing</keyword>
    <feature type="chain" id="PRO_0000397633" description="rRNA biogenesis protein rrp36">
        <location>
            <begin position="1"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="303"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="221"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="33"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="123"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="146"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="303"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="323"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="352" mass="39212" checksum="FF41FC16998C21C3" modified="2005-04-26" version="1">MAISDLLNRRVRAAPDEDEEVYSDESASGSEPPSDEGSSDESGSESGRDSLNGSDNDFDSESQNSEASDSISEDEDDDGDVKSSLNNISFGALAKAQASFAPQTKRRTKNLKDNEGTTASPLDDIRAKIQEAREQKRKASLASKDSSAKSRVDKPPPRTSKHAPTVQSSKYAVSRKRTIIEPPSVPKSRDPRFDPTIVGGRGGSGSSAPSDAYAFLDDYRAAELRALKEQLAKTKDVRRREALQREIRSMTDRLRTIENHKREKEILSEHKKREKQLIREGKKATPYFLKKSDIKKQALLKKYEGMKSKDRAKALERRRKKAAAKERKEMPMERRGLGGDSDAAPSKRRRMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="124" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B1D7</accession>
    <accession>C8VFV4</accession>
    <name>Q5B1D7_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">SNF2 family helicase/ATPase, putative (AFU_orthologue AFUA_4G13460)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">ANIA_05643</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family. ISWI subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF81492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_663247.1">
        <property type="nucleotide sequence ID" value="XM_658155.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B1D7"/>
    <dbReference type="FunCoup" id="Q5B1D7">
        <property type="interactions" value="1117"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5B1D7"/>
    <dbReference type="GeneID" id="2871937"/>
    <dbReference type="KEGG" id="ani:ANIA_05643"/>
    <dbReference type="eggNOG" id="KOG0385">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000315_0_2_1"/>
    <dbReference type="InParanoid" id="Q5B1D7"/>
    <dbReference type="OMA" id="VHDYQFF"/>
    <dbReference type="OrthoDB" id="5857104at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031010">
        <property type="term" value="C:ISWI-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140750">
        <property type="term" value="F:nucleosome array spacer activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd17997">
        <property type="entry name" value="DEXHc_SMARCA1_SMARCA5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000036">
        <property type="entry name" value="Chromatin remodelling complex ATPase chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000082">
        <property type="entry name" value="ISWI chromatin remodeling complex ATPase ISW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000022">
        <property type="entry name" value="ISWI chromatin-remodeling complex ATPase CHR11 isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.1190:FF:000005">
        <property type="entry name" value="ISWI chromatin-remodeling complex ATPase ISW1"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="1.10.10.60:FF:000234">
        <property type="entry name" value="ISWI chromatin-remodeling complex ATPase ISW2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.30:FF:000003">
        <property type="entry name" value="ISWI chromatin-remodeling complex ATPase ISW2"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1190">
        <property type="entry name" value="iswi atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.30">
        <property type="entry name" value="ISWI, HAND domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
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    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044754">
        <property type="entry name" value="Isw1/2_DEXHc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015194">
        <property type="entry name" value="ISWI_HAND-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036306">
        <property type="entry name" value="ISWI_HAND-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015195">
        <property type="entry name" value="SLIDE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623:SF49">
        <property type="entry name" value="SWI_SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY A MEMBER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09110">
        <property type="entry name" value="HAND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09111">
        <property type="entry name" value="SLIDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101224">
        <property type="entry name" value="HAND domain of the nucleosome remodeling ATPase ISWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6 14" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="205"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="501"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="13">
        <location>
            <begin position="867"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="137"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1041"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="42"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1041"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="1058"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1092"/>
            <end position="1101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CBF81492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="1111" mass="127247" checksum="B35A3EA2358748E8" modified="2005-04-26" version="1">MAPAAVPTSDPPSQADTPMTDANEEITSVPVDPLDAKMTDTPDYTDSDTNPNTTASSVAGDVVPSDGRRRRSEAFQMRKNMFGKKHGSLNENKDDDSIRRFRYLLGLTDLFRHFIESNPNPRIKEIMAEIDRQDAEEAAKSKRKVSARSGGASGERRRRTEQEEDAELLSDEKRGGGTNTIFRESPPFIQGEMRDYQIAGLNWLVSLHENGISGILADEMGLGKTLQTISFIGYLRHLCDITGPHLVAVPKSTLDNWKREFHKWTPEVNVLVLQGDKEERHKLINERLLDEDFDVCITSYEMILREKSHLKKFAWEYIIIDEAHRIKNEESSLAQIIRVFNSRNRLLITGTPLQNNLHELWALLNFLLPDVFGDSEAFDQWFSNQEADQDTVVQQLHRVLRPFLLRRVKSDVEKSLLPKKEVNLYVPMSSMQVKWYQKILEKDIDAVNGAGGKKESKTRLLNIVMQLRKCCNHPYLFEGAEEGPPYTNDVHIINNSGKMVILDKLLARMQAQGSRVLIFSQMSRVLDILEDYCALRKYQYCRIDGTTAHEDRIAAIDEYNKPDSDKFIFLLTTRAGGLGINLTTADIVVLYDSDWNPQADLQAMDRAHRIGQTKQVVVYRFITESAIEERVLERAAQKLRLDQLVIQQGRAQQQAKNTASKDELLGMIQHGAAEIFNKQGGTSTLQEGKDITDDDIDAILRKGEERTAELSKKYEQLGIDDLQKFNSESAYEWNGKDFTTDKKKDIGIHWINPAKRERKEQFYSIDKYYRQALATGGRTADPKPKVPRAPKQIAIHDWQFFPPGLQELQDKETAYFHKEIGYKVPLPDGPEELTHREAERDLEQAMIDNAAPLTEAEQAEKTKLSEQGFSDWNRRDFQQFINGSAKFGRTDYAGIATEVDSKDPKQVEEYANVFWKRYTEIQDYPKYIRVIEQGEEKLRKMGHQRKMLRKKMEMYRVPLQQLKINYTVSTTNKKVYTEEEDRFLLVMLDKYGVEGEGLYEKIREEVRESPLFRFDWFFLSRTPVEIGRRCTTLLNTIAKEFEPDGKNGDGKGRGRDREDDELDNEDDVPAKKKTKGAVNKQVKAVKGSKGNSASTSRASSANPPKSRGRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="119" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B1R1</accession>
    <accession>C8VG96</accession>
    <name>Q5B1R1_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AP complex subunit sigma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ANIA_05519</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the adaptor complexes small subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF81752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_663123.1">
        <property type="nucleotide sequence ID" value="XM_658031.2"/>
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    <dbReference type="AlphaFoldDB" id="Q5B1R1"/>
    <dbReference type="FunCoup" id="Q5B1R1">
        <property type="interactions" value="417"/>
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    <dbReference type="STRING" id="227321.Q5B1R1"/>
    <dbReference type="GeneID" id="2871807"/>
    <dbReference type="KEGG" id="ani:ANIA_05519"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN5519"/>
    <dbReference type="eggNOG" id="KOG0936">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061221_2_0_1"/>
    <dbReference type="InParanoid" id="Q5B1R1"/>
    <dbReference type="OMA" id="DLIFNWQ"/>
    <dbReference type="OrthoDB" id="10261046at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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    <dbReference type="FunFam" id="3.30.450.60:FF:000001">
        <property type="entry name" value="AP complex subunit sigma"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016635">
        <property type="entry name" value="AP_complex_ssu"/>
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    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
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    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
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    <dbReference type="PANTHER" id="PTHR11753">
        <property type="entry name" value="ADAPTOR COMPLEXES SMALL SUBUNIT FAMILY"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="AP_complex_sigma"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="SNARE-like"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AP complex mu/sigma subunit" evidence="7">
        <location>
            <begin position="1"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR015588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBF81752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="185" mass="19836" checksum="ED57F66CEA49DAF4" modified="2005-04-26" version="1">MINAVLVFNNNGQPRLTKFYTQIDTQTKQSLIAQIYDLVAQRPPTACNFLPLPPILARGASSSASTGPSDAPTQITYRTYATLSFIMISTSTESPLALIDLIQVFVEALDRIFENVCELDLIFGFETMHAVLSEMIVGGVVVETNIDKIVAGVQSQEGSLGKKRAIQAASSGVGRGGLSGLAAWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B1R7</accession>
    <accession>C8VGA3</accession>
    <name>Q5B1R7_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Leucine rich repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_05513</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF81765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_663117.1">
        <property type="nucleotide sequence ID" value="XM_658025.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B1R7"/>
    <dbReference type="GeneID" id="2871804"/>
    <dbReference type="KEGG" id="ani:ANIA_05513"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN5513"/>
    <dbReference type="eggNOG" id="ENOG502S5T4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018351_0_0_1"/>
    <dbReference type="InParanoid" id="Q5B1R7"/>
    <dbReference type="OMA" id="CKSIIWR"/>
    <dbReference type="OrthoDB" id="9876299at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="393"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="572"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="275"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="572"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="611"/>
            <end position="625"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF81765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="707" mass="77471" checksum="383259918E9DE6F8" modified="2005-04-26" version="1">MSKTAITEIRTDNFLKSFTCQRLEQHSTKRLYCGFVVFERKTDYSTMTMGRLTYSARKIGGIKAGQVVSKDLKKRIPPGLGSKAAARDPTLELDLTGKCLTDEGFAQFIDDLIECIWYRDEAHPAGLAKVTEVHLQGNNLTIYSLPKLGEVIAKSPGDLRELDLSNNNIRVVTAEEKAIWKSFLCCFKNCYVLMKLDLSGNPLGVAGLEILASVYIKSDLEYLEADADAIVRENLGLASDSVLAGETGALKIGENSSKENTDPRSGMGRSKKSPNKGGKTGKQNGTPTTVISSKNISFADLKKYACTRGLRSVPYFILSNLELRTSSAVHLSRMLATQRAAEQLLTFLPPAKASAIPESAEEGKSIIWQPNDGLGATAKRLLEVTESILAQKTKTQAQEVSDGDENTYERAEGSETDEDTKRKVQSKLALEFTRLTKRVRLEALKQEGTCASDIAITALQMMVVSRALLLEDRDRVVEASKIERAEAPLNTEGPTFEEGQEGLQGQEYVLEVEPSVEQPLSPVEYLPEPQYTFPQSFATGPFHPGAKLFDEEFPALQPILHEPPRLLTKPATTEPEVEEAAAPSVITGPSSSPGYPASSENGTKANGGSGSSHPTRSGKGNSRFSVAQKARKSSWRYNLPTEIWQRIIADAVGANGILDQEQQQRIMQYAADWDAVAYELTIKGAEDHQQIWKFLQTVGCFTYSPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B2R9</accession>
    <accession>C8VF32</accession>
    <name>Q5B2R9_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ANIA_05161</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF80990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_662765.1">
        <property type="nucleotide sequence ID" value="XM_657673.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B2R9"/>
    <dbReference type="STRING" id="227321.Q5B2R9"/>
    <dbReference type="GeneID" id="2871455"/>
    <dbReference type="KEGG" id="ani:ANIA_05161"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN5161"/>
    <dbReference type="eggNOG" id="ENOG502SJQV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_357152_0_0_1"/>
    <dbReference type="InParanoid" id="Q5B2R9"/>
    <dbReference type="OMA" id="CRENIDY"/>
    <dbReference type="OrthoDB" id="5422579at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004568">
        <property type="term" value="F:chitinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF80990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="785" mass="90276" checksum="4F45635406BD5DF0" modified="2005-04-26" version="1">MIASYLPNSSIKTLRMTCKPLCNTVSLRLDRAFLSANPLNIAVFRAIADSERFRHGIEEIIWDDARFIKAPLGEFHIADEREDLWIDEETGCPEWFVNSCKENRKDLEMGNYPDQGRIEQIALIEEQAAAEPPLKIFWQYYQNLLQQQEDTIIFDMDAEALEYGLRRFPALKRVTITPAVHGWLFTPLYETPMIRAFPKGFNYPIPRGWPDNPEGTFTPEATPWEDEATRKDFRGFGIVTRALASYADHHVSELIITANTLQTGLNCCVFETHNAQYTDFAAILRKPGFARLDLSLLVCGQERTGWPAYRDGLLRRALSGAHGLEHISLSTNIEEDPASDSTIPWSAGGRDQLVPLRTIFPVDEWKSLRHFSLSGFHVDKDDIISFLFALPPTLRSVYLGFLYFVDHGGSYRELLIDMRDQLDWRKRDPADRPVVSLAKPTSYNRIGHAVWLDNEKRRKIRNYASPAHTYTSACNPEDLHVLIPRVDGQATMGTKKVTACGNSHWLTGDWRYPAFPSRPDYDWEGIENGARDSISCYWGNTSDSCSNWAVGGLTSHDTRWARDTNGSPTRIRTNYQTEHVFEGQLIGDFFDWWLEQGKIKNQRPIPASASSKFPCSSSEDYFLRPRAYYPWTLDGKQTAFINVLLSELDVYGQRANRPRQIQAHGQRRSIAACLKRWEVWDKFCSTYEAIYGHFGSWDNWHRQAGYPAGPLPSMQDEWKEYIRVVLDSFVLRARDTFDFMLRERKTTHLLATDPPFDGHWLSNRFVIRMFLRLSLGCNNMDASRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B312</accession>
    <accession>C8V811</accession>
    <name>Q5B312_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cyclase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_05068</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Cyclase 1 superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF76157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_662672.1">
        <property type="nucleotide sequence ID" value="XM_657580.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B312"/>
    <dbReference type="GeneID" id="2872867"/>
    <dbReference type="KEGG" id="ani:ANIA_05068"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN5068"/>
    <dbReference type="eggNOG" id="ENOG502QU9Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030671_1_1_1"/>
    <dbReference type="InParanoid" id="Q5B312"/>
    <dbReference type="OMA" id="QVWVGKP"/>
    <dbReference type="OrthoDB" id="5396at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004061">
        <property type="term" value="F:arylformamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.50">
        <property type="entry name" value="Putative cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007325">
        <property type="entry name" value="KFase/CYL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037175">
        <property type="entry name" value="KFase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34861">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34861:SF8">
        <property type="entry name" value="CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04199">
        <property type="entry name" value="Cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102198">
        <property type="entry name" value="Putative cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF76157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="347" mass="39239" checksum="9C71618415215E42" modified="2005-04-26" version="1">MADSKLSQSPYDIPYDELANPRQVWVGEPGSEEEGKAKLGMLTPEVVHGAAASEIRTGRRVTMGWTLTELGYPNLGRQPCKHRIVPLLDGLAFDDYYEFNPQQSSQWDGLRHFSQTVPGQSERVFYGGTTAAEIYDRKNDRIGMQHWAKEGIAGRGVLIDYASWAKKKGIKYSTFSTHQVRLSDIQEIAKECEIEFKKGDILFVRIGVTEEWDTMTEAQKQEYSNNSKPLHAGVEATEDMLRWLWNEKFAAIASDAISWEVYPPQSDIFLHEYVLAGWGMPIGELFDLEALARMCIEHKRWSFFVASIPLNMPGVPATPKAPEVLDQSNISKFQHASIVMDVFETRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B3J9</accession>
    <accession>C8V9T9</accession>
    <name>Q5B3J9_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_04881</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF76563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_662485.1">
        <property type="nucleotide sequence ID" value="XM_657393.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B3J9"/>
    <dbReference type="STRING" id="227321.Q5B3J9"/>
    <dbReference type="GeneID" id="2872680"/>
    <dbReference type="KEGG" id="ani:ANIA_04881"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN4881"/>
    <dbReference type="eggNOG" id="ENOG502RZ4H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025591_0_0_1"/>
    <dbReference type="InParanoid" id="Q5B3J9"/>
    <dbReference type="OMA" id="HSRCETP"/>
    <dbReference type="OrthoDB" id="2163387at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40468:SF1">
        <property type="entry name" value="TOPOISOMERASE I DAMAGE AFFECTED PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40468">
        <property type="entry name" value="YALI0A15257P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="44"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF76563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="361" mass="39227" checksum="F330F53895C7C2B6" modified="2005-04-26" version="1">MVPSNPEKTIRKIDIAQVSLNLQDRLGLAKVKYQNGRLPSRQNGGLHISLGLGSSDKPSDSSSDISNSRCETPLTSPLRASSYSYSKELPRSSRNRHAVTFNSRVMQPMLSASRKRLRSDSAADIDRPAKASRASWKRSHQLPESSPGFRRHTSTRRGRNNLPLISETAPIPELSSPGPGYHAHSDDENDLDLPVHSFQVSSVVGSSPPRTPPPKHSSLSRNDRNLRHEDGADLLLYLANSPTPARVANKPQPQEFPPSTPPSQHAALPSLTPTPGGGLFPNFGTPNQQFNFADFVNVTPSPAQPAWGGRTPGGLARTPLASKDVRRRSNLDNLLPPGLDSPKIREKRPSAVLQLGGELRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B533</accession>
    <accession>C8V942</accession>
    <name>Q5B533_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Survival Motor Neuron Gemin2-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ANIA_04347</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SMN family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF77713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_661951.1">
        <property type="nucleotide sequence ID" value="XM_656859.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B533"/>
    <dbReference type="STRING" id="227321.Q5B533"/>
    <dbReference type="GeneID" id="2872146"/>
    <dbReference type="KEGG" id="ani:ANIA_04347"/>
    <dbReference type="eggNOG" id="KOG4327">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093937_1_0_1"/>
    <dbReference type="InParanoid" id="Q5B533"/>
    <dbReference type="OMA" id="MMSWYFA"/>
    <dbReference type="OrthoDB" id="197400at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22852">
        <property type="entry name" value="SMN_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22851">
        <property type="entry name" value="SMN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040424">
        <property type="entry name" value="Smn1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047313">
        <property type="entry name" value="SMN_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049481">
        <property type="entry name" value="SMN_G2-BD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39267:SF1">
        <property type="entry name" value="SURVIVAL MOTOR NEURON PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39267">
        <property type="entry name" value="SURVIVAL MOTOR NEURON-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20636">
        <property type="entry name" value="SMN_G2-BD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Survival Motor Neuron Gemin2-binding" evidence="7">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="86"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="180"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="95"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="117"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="185"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBF77713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="206" mass="22684" checksum="794D73D0638E68E3" modified="2005-04-26" version="1">MGKNKGASRALTQEEIWDDFALVQSWDEAVEEYKLYHSIAAKGENVEDVLREAEAAAEAETGPSMSWAQVEKDDDMADVNAADSVQPAAAPAETQGMQARLQTQEAAGSEQVKQEQETAAATGPQAQAPTMPYPAFPQTQDEGLKNLMMAWYYAGYYTALYQEQQQLATVIYRSWQPRLRANQPAPRNQATARNTGPSGMARRHSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B568</accession>
    <accession>C8V982</accession>
    <name>Q5B568_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_04312</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF77788.1"/>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_656824.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B568"/>
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    <dbReference type="KEGG" id="ani:ANIA_04312"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN4312"/>
    <dbReference type="eggNOG" id="ENOG502REX9">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_016576_0_0_1"/>
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    <dbReference type="OMA" id="HDPYRPV"/>
    <dbReference type="OrthoDB" id="5417135at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42088">
        <property type="entry name" value="YALI0F10131P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42088:SF1">
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    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="195"/>
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        </location>
    </feature>
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        <location>
            <begin position="485"/>
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        </location>
    </feature>
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        <location>
            <begin position="572"/>
            <end position="595"/>
        </location>
    </feature>
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        <location>
            <begin position="276"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF77788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="697" mass="76377" checksum="E50BF211977F14B8" modified="2005-04-26" version="1">MHRHQQHQHRHGKYLGARFAPVEPALMPRNRPPYLLMPEAPTLVKREPMPTTDSGRVETCSPGDNSARCEKNTSTASNTTLPVVLGAVIPIVCAIIVLIFLHRRNVKKLRNEDANDKHKSLDFGMDLAPSGGRSGMQEKGSHHMKGISLDIGPSPYMLPPSIRGSKDSLNSLPRTILADDDKYRHAHTYFSTDAQSIRSQRRVHDDAASVAGSTRRGAFGDEMNQGLLGNAQRISRSSPPLYNPPEPTAGRAQPQVQDAGFELSLPRSPSPVHVSGLTSINESTTETGREANVPRRISSPLNCPPEHQFDLPLQDTPATHAGPDHNPSHDKPIAMPRISLPSSDVDSDYGDQRTSGPAVPAVNVQTAGIGSTPHEESPDQVPKPAMPEEPSQSSNLNLDPRRDTRRLTMGLRPLPPEDPSDNPEQRANRIRSFYKEYFDESKAGQRETYYGDYGADYYPHDDDYVYDPVTGEYYDAVPAPYAEPMTRRAMTPPPRAPPRFQGAAHHMASGSIGGYSDRFQPPGPRAFSSASNRFPGPRAPRRPAPPPAPLNVLPSPHLLKDDSIMTAIDFAPGSSFRDQRDGRPETPLGGVRPYSPTVRAHTPLVSVFDDLAPMPSPHALRKSGAFGNLDFAPPPRFKTQDTASDAGSIRSTRTGVSATHLQNIRNGAYHVSRLPPETVGTKDDLISNLRPKWDMRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B5R4</accession>
    <accession>C8V519</accession>
    <name>Q5B5R4_EMENI</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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        <name evidence="1" type="ORF">ANIA_04116</name>
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        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF74673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_661720.1">
        <property type="nucleotide sequence ID" value="XM_656628.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B5R4"/>
    <dbReference type="GeneID" id="2873539"/>
    <dbReference type="KEGG" id="ani:ANIA_04116"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN4116"/>
    <dbReference type="HOGENOM" id="CLU_746021_0_0_1"/>
    <dbReference type="InParanoid" id="Q5B5R4"/>
    <dbReference type="OrthoDB" id="5125733at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF74673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="371" mass="40326" checksum="6241557D6379A84A" modified="2005-04-26" version="1">MQVSVVSGQDAIAINLPARYEQRLRLDTIYPFQTEFTRAAFSTAAAVYKTEPFTLRDMVSSAENGCRGCRFLAAVLAGVGSVYAYTELELAGMAFKWLGSSFTLDMTMEDGTQSSGGCFSETIPDSCILIPDPGWPAVYLGVRDCQGAGTIVQGPLPALHAIVGVSGTDALTTDSLLHKLEFQVGCQGGLSYECGGDSIAPHFKPVPTVMNVAKLKTLSELKAAEGGGGLVGDDFTMLIYRNWVDIVVSYAKLDITVPSDRFSAISVTAKIVSRNMKSEYLAGIWRATFMEEGLLWAHSAVTVEADGPLNQDWTRCTFAEPALDLMGAKLSFYADAYIDRDKYGFWNALAKGRAGLRHVIYFMFLERDALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="100" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B634</accession>
    <accession>C8V5U8</accession>
    <name>Q5B634_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_03996</name>
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    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
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            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
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        <property type="entry name" value="SAM-dependent_MTases_sf"/>
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        <property type="entry name" value="JUVENILE HORMONE ACID O-METHYLTRANSFERASE"/>
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        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase" evidence="1">
        <location>
            <begin position="71"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF74924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="221" mass="23613" checksum="29058C2C0493E3A6" modified="2005-04-26" version="1">MSTKTQVITENAHLASARGAVSKEACMALYDHWASSYNKDLADASQNYVAPILTAQTAVQMINSAMAPVTVLDAGCGTGLVGQALASLKHGAITIDGADLSLPMLKIAEETGVYRTLTQVDLTQPIGAPDGTYDVVTCCGTFTQGHVGPDPALREFVRLVKPGGFVVATVLHEIWLEWGFKTEAERLEKEGLVRVVSTEVMDYRRGAGDKATFLVLKKTQA</sequence>
</entry>
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    <accession>C8V6I2</accession>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
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            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
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                <person name="Cornell M.J."/>
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                <person name="Visser J."/>
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            <dbReference type="PubMed" id="19146970"/>
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        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
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        <property type="component" value="Chromosome II"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="103" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="6" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
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                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
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            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001302">
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        <property type="nucleotide sequence ID" value="XM_656061.1"/>
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    <keyword evidence="2" id="KW-0804">Transcription</keyword>
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        <location>
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            <end position="83"/>
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    <feature type="DNA-binding region" description="HMG box" evidence="3">
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    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50118"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="CBF75908.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="573" mass="64168" checksum="1759DC48EE77282A" modified="2005-04-26" version="1">MDSLCSCQPKPRIPRPRNAFFLYREAHYKAVVASAEVSPLPSTTVAKILGRQWRDLPESAKAEWKELAEEEKRQHKQRYPDYRYCPSSRICSQCGGRQIRGAKSHREGSSGSPARVASDEIMDLVPSREMMLEWSDYSDEQVCQLFSLPEKGEDQVARPITPSPPPFSTIKPCLLEKQHGRWTLCSILLPTDHGYGSQVTLFDSCLTYRMLHVVGWMAITTGEAYFKLTDDTIRELAEYYNSTCTDLSRQQRFLAAAYAFCYSVGYNEILDALEDDGSGELKVSVTVTQVTVLVTVTTTGTGVLLVELRIVVESMTTGEGALLEGGVLLRNNAVLEEAIPVLALLSFEGVDNPFLEHEEGIISGHVKFRSNRDIKLFLTLERAEEPEALRDTYICDVHGQCCLIEDHLSCWLRTQQEQHKEAMVSPQQLPSNWNRLRNARRHKHSVSVAYVLAAALHFLAPEASPNPVKEAAWDYSHSDHSSIVALVGLDTPQAQTGRETFKVGRRAPMAENLVILGSDFLLWNGIKRGGGRHSIHGLKGSWCQVCATLNFQVGVTAWRQKEFTKESGLGQFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="122" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B7R7</accession>
    <accession>C8VHK7</accession>
    <name>Q5B7R7_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein uS5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">40S ribosomal protein S2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ANIA_03413</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the universal ribosomal protein uS5 family.</text>
    </comment>
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        <property type="protein sequence ID" value="CBF82758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_655925.2"/>
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        <property type="interactions" value="831"/>
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    <dbReference type="KEGG" id="ani:ANIA_03413"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN3413"/>
    <dbReference type="eggNOG" id="KOG0877">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_065898_0_2_1"/>
    <dbReference type="InParanoid" id="Q5B7R7"/>
    <dbReference type="OMA" id="PYEEWSD"/>
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        <property type="component" value="Chromosome VI"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="F:small ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
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        <property type="term" value="F:structural constituent of ribosome"/>
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    <dbReference type="GO" id="GO:0045903">
        <property type="term" value="P:positive regulation of translational fidelity"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="P:ribosomal subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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        <property type="evidence" value="ECO:0000318"/>
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        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
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    <dbReference type="InterPro" id="IPR000851">
        <property type="entry name" value="Ribosomal_uS5"/>
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        <property type="entry name" value="Ribosomal_uS5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005711">
        <property type="entry name" value="Ribosomal_uS5_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013810">
        <property type="entry name" value="Ribosomal_uS5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018192">
        <property type="entry name" value="Ribosomal_uS5_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01020">
        <property type="entry name" value="uS5_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13718:SF4">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13718">
        <property type="entry name" value="RIBOSOMAL S SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00333">
        <property type="entry name" value="Ribosomal_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03719">
        <property type="entry name" value="Ribosomal_S5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00585">
        <property type="entry name" value="RIBOSOMAL_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50881">
        <property type="entry name" value="S5_DSRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="S5 DRBM" evidence="9">
        <location>
            <begin position="82"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBF82758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="259" mass="28237" checksum="5FC68FBB65F5B88E" modified="2005-04-26" version="1">MADAAPRGRGGFGSRGDRGGDRRGRGRGRGRRGGKTEEKEWQPVTKLGRLVKAGKITSMEQIYLHSLPVKEYQIVDFFLPKLKDEVMKIKPVQKQTRAGQRTRFKAVVVIGDSEGHIGLGIKTSKEVATAIRAAIIIAKLAVLPVRRGYWGTNLGEPHSLPVKQSAKCGSVSVRLIPAPRGTGLVASPAVKRLLQLAGVQDAYTSSSGSTKTLENTLKATFLAVVNTYGFLTPNLWTETKLTRSPLEEFSDVLRQGKKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B7W3</accession>
    <accession>C8VHQ7</accession>
    <name>Q5B7W3_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Translin-associated factor TraX, putative (AFU_orthologue AFUA_7G01330)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ANIA_03367</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the translin family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF82849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_660971.1">
        <property type="nucleotide sequence ID" value="XM_655879.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B7W3"/>
    <dbReference type="STRING" id="227321.Q5B7W3"/>
    <dbReference type="GeneID" id="2874284"/>
    <dbReference type="KEGG" id="ani:ANIA_03367"/>
    <dbReference type="eggNOG" id="KOG3066">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067225_2_1_1"/>
    <dbReference type="InParanoid" id="Q5B7W3"/>
    <dbReference type="OMA" id="DTCMETC"/>
    <dbReference type="OrthoDB" id="31005at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14820">
        <property type="entry name" value="TRAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.190:FF:000008">
        <property type="entry name" value="Translin-associated factor TraX, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.200:FF:000004">
        <property type="entry name" value="Translin-associated factor TraX, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.190">
        <property type="entry name" value="Translin, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.200">
        <property type="entry name" value="Translin, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016069">
        <property type="entry name" value="Translin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002848">
        <property type="entry name" value="Translin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016068">
        <property type="entry name" value="Translin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036081">
        <property type="entry name" value="Translin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10741">
        <property type="entry name" value="TRANSLIN AND TRANSLIN ASSOCIATED PROTEIN X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01997">
        <property type="entry name" value="Translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74784">
        <property type="entry name" value="Translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBF82849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="296" mass="33561" checksum="BE5958C22D0B82E6" modified="2005-04-26" version="1">MENKTDNSSAGTKRSWEGLPLHNDGKSQRFPSTTMVESASFDVLSMFEGFRDELDQHHDRRERLIKISRDITALSKKMQTLQSPNHSHSRVRTAGAPIPPSILKDVQSRFTQINDLFLSAVPETQGLNNYRYLRNLSGGIQEFIEALSFKHYLETQTLITREQVTSHLPPDILVTEDDYVMGLFDLTGELMRFAVTSLSAGNHTENDENGDGLPRLPPAQAGVVRDLREIRAEFEGVTIPRRHDYQIMRDWGKKTEIMCSSVEKVERAAYGILVRGSERPKGWKPDLSGPVEMDVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="108" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B8I2</accession>
    <accession>C8VIG7</accession>
    <name>Q5B8I2_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PH domain protein (AFU_orthologue AFUA_3G13830)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_03148</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF83310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_660752.1">
        <property type="nucleotide sequence ID" value="XM_655660.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B8I2"/>
    <dbReference type="FunCoup" id="Q5B8I2">
        <property type="interactions" value="9"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5B8I2"/>
    <dbReference type="GeneID" id="2874120"/>
    <dbReference type="KEGG" id="ani:ANIA_03148"/>
    <dbReference type="eggNOG" id="ENOG502QRAT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003938_0_0_1"/>
    <dbReference type="InParanoid" id="Q5B8I2"/>
    <dbReference type="OMA" id="DRWVMSI"/>
    <dbReference type="OrthoDB" id="5579281at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005628">
        <property type="term" value="C:prospore membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902657">
        <property type="term" value="P:protein localization to prospore membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040345">
        <property type="entry name" value="Mug56/Spo71"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039486">
        <property type="entry name" value="Mug56/Spo71_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057379">
        <property type="entry name" value="PH_SPO71"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029217">
        <property type="entry name" value="Spo7_2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28076:SF1">
        <property type="entry name" value="PROSPORE MEMBRANE ADAPTER PROTEIN SPO71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28076">
        <property type="entry name" value="SPORULATION-SPECIFIC PROTEIN 71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15404">
        <property type="entry name" value="PH_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23207">
        <property type="entry name" value="PH_SPO71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15407">
        <property type="entry name" value="Spo7_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01316">
        <property type="entry name" value="Spo7_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="857"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="716"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="731"/>
            <end position="744"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF83310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="1055" mass="119723" checksum="664D13447AB93C6D" modified="2005-04-26" version="1">MEHGCQNSGDGHPGLEQDSYTLEKLRHASATHVHITSRRFFIGPIPKNWLQSHRKSWYRKRLSSRDYRSRAVTFSAESDYAQETGQSASDPPSIEPEENESETEIEQDSGQETPRLTQDLRVLTHEYEDNDEPPPSVDPRGGDTPGTKTDSRSAYFTAREGNASLSTITPVQSARHAQFQNSRLLAVPHSVRGRSIHSHLNNTQPSLPATPSESGSMEPLLSVPRNKDKSEQHSVPPASLQRHEPQRGVSEGDDGSNDWRQDRTSRAPHIANPLTVNDNLHARRRRIASKISRTQGRVPDWFSRHRVEVGEVIKAEKMLIRVEETAQDELPEDYSEFDSLRMETRVQDNWREFLVVCRSASDKEAPYTLQMYKTRVIPKIQEQGRASPYHEIALGRKTVKVNLYSALDKTIAVWKRSKRGTTIYILRPKSTARAVEWYTFIAYTMGRRRASSLGITVPDLAVSLVFNNPFKQVGFANSSGHEGPEEIVKQTSAYDSIIQGCLTMLEDRPEWSAVMKRWTSTEKLGLAWKRYDRLEWIYGVNEKDMYGSVGMQGTHELELRPKQHYDTSVGYGAKKKEEPAPVEGFLIRLTSQTGAHQRMNRMFSKRLYFFSQDHYLFFCKPSQALPPTPPWLSALDSGIPSTQEILDKAPLSYEIDPFPLQDGQISWLSIGNTEHQKRRDEEAYAQFQRDIHNLSNADGFINLCLVQEVRSIPDDFSSASNTRETCDRGITQPNDPSQLQAGNVGEQSTDNAGFEMLLDNGLVVRFQAYNSATRDEWMQRLDALVQYWKARIVADAAELKNTRQRNLELLGMDEELESVIGQYAKKWEVRKAEASPLLHNMCSLIGCRPIKTSPNLSMEMSGLLYKKPRRHATFKRFHVILTAGKLLVYHSSLRKYNGAEVPHVHSTLESTIDLENCYIYSGLIAENDLLYSNQTFDSNHPGHGALPRVYLSSDMYTSSDEDTAITFVIWQPLRKGLFRAREREVEGGESGDGHGGGRVKTRQTLKQVSKLGVHGRTIVFKARSRVEKDRWVLCIASEINRLQEGKAEDVRLTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="99" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B8P5</accession>
    <accession>C8VIN7</accession>
    <name>Q5B8P5_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphatidyl synthase (AFU_orthologue AFUA_3G12330)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_03085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF83435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_660689.1">
        <property type="nucleotide sequence ID" value="XM_655597.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B8P5"/>
    <dbReference type="FunCoup" id="Q5B8P5">
        <property type="interactions" value="241"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5B8P5"/>
    <dbReference type="GeneID" id="2874511"/>
    <dbReference type="KEGG" id="ani:ANIA_03085"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN3085"/>
    <dbReference type="eggNOG" id="KOG1618">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030880_3_1_1"/>
    <dbReference type="InParanoid" id="Q5B8P5"/>
    <dbReference type="OMA" id="RDWASDQ"/>
    <dbReference type="OrthoDB" id="10251048at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046474">
        <property type="term" value="P:glycerophospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000069">
        <property type="entry name" value="HAD-superfamily subfamily IIA hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050324">
        <property type="entry name" value="CDP-alcohol_PTase-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006357">
        <property type="entry name" value="HAD-SF_hydro_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006353">
        <property type="entry name" value="HAD-SF_hydro_IIA_CECR5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01456">
        <property type="entry name" value="CECR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01460">
        <property type="entry name" value="HAD-SF-IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269:SF4">
        <property type="entry name" value="CAT EYE SYNDROME CRITICAL REGION PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13344">
        <property type="entry name" value="Hydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13242">
        <property type="entry name" value="Hydrolase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="68"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF83435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="450" mass="49919" checksum="C76B9FBDA56CA0E1" modified="2005-04-26" version="1">MSVYSQQSYTDAISNGNRYRRLSNNAAERADLFTGPNVLVPPKHLMASSQPADLAVEMEMAKQRMESDTSSTASAESPLAASPATSPLIPASTTTTDEFALAFDIDGVLIRGGKPIPAAIEAMKYINGDNPYGVKVPYIFVTNGGGKTEEERCLDLSRQLELEVAPGQFICGHTPMKEMAQKYDTVLVVGGEGEKCRIVAEGYGFRNVITPGDFIKTHHDTTPFRKLTEEEYNNSRVLDLETLRIDAIFVFADSRDWAGDQQIILDCLMSKNGNMLERSTTFDEGPPVFFSHNDVVWSTSHQHSRIGMGALRASLEALYKAVTGKELTTVAFGKPQLGTYEFATRLLRQWRKEFHGINKPPKTVYFVGDTPESDIRGTNKFNEISDTDWFSILVKTGVYQEGTIPRYPPKKTCGTVLDAVKFAINRELGLKTDDLRNNEPSPERYGEVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B923</accession>
    <accession>C8VJ21</accession>
    <name>Q5B923_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Miscellaneous Zn(II)2Cys6 transcription factor (Eurofung)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ANIA_02957</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF83674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_660561.1">
        <property type="nucleotide sequence ID" value="XM_655469.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B923"/>
    <dbReference type="STRING" id="227321.Q5B923"/>
    <dbReference type="GeneID" id="2874023"/>
    <dbReference type="KEGG" id="ani:ANIA_02957"/>
    <dbReference type="eggNOG" id="ENOG502QRH3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008719_5_0_1"/>
    <dbReference type="InParanoid" id="Q5B923"/>
    <dbReference type="OMA" id="TCWRIRD"/>
    <dbReference type="OrthoDB" id="415590at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF24">
        <property type="entry name" value="MISCELLANEOUS ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="99"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="15"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="44"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="108"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="118"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBF83674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="547" mass="61436" checksum="B6B11D0A11262D5D" modified="2005-04-26" version="1">MFSIEPPSKRPRLDQPSQTHSRSHSYSAEFLDETTGAEECATLPSANTRPPESSTTSNHDVFHSSPGSWYQDGFSQDPGFLASQEELRAILFTLANSAAPTRASSPEAGKKAPELDLRTSTSPSTTVTRPYHHYQTHQEQRRTAAPSRSPLSSRRRIEYLKNYVAEIAPWLDMFDSSCTFRQQLPALSHSFPALLYAILAISARQMERKSGTQGWCDSLELYQEAIRLLSPLIQVRDPKIVAACVLLCCLEMMSARAQDWHRHLEGCAALFEASGIHGFCGGLLQAVFWCYARMDLCGALISDGTRTTVLHPSKWLPVGCQEEDAYRLFKEARTPDMHANYAVYLAVKTTELVSNRTKFIELGEANGCTTEVFATRWGSLWDELQTWLAERPPELLPIQTIPRKPFPYILFVHWAAISSNQLYHTACILLLKMMPKGLRIPRSPTLSLLWHARRICGISISNKHQGCLNNAIQPLWIAGRLFSHASEHEQIVNTIRGIEAETGWGACWRIRDLELAWGYAVSGDRREMINQQFSASMDGDAHQVSSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="124" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B9Q0</accession>
    <accession>C8VJZ6</accession>
    <accession>Q2V9Y5</accession>
    <name>Q5B9Q0_EMENI</name>
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        <recommendedName>
            <fullName evidence="7">STAS domain-containing protein</fullName>
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    <gene>
        <name evidence="8" type="ORF">ANIA_02730</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF84130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_660334.1">
        <property type="nucleotide sequence ID" value="XM_655242.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B9Q0"/>
    <dbReference type="FunCoup" id="Q5B9Q0">
        <property type="interactions" value="453"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5B9Q0"/>
    <dbReference type="GeneID" id="2873886"/>
    <dbReference type="KEGG" id="ani:ANIA_02730"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN2730"/>
    <dbReference type="eggNOG" id="KOG0236">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003182_8_1_1"/>
    <dbReference type="InParanoid" id="Q5B9Q0"/>
    <dbReference type="OMA" id="VMLIEHI"/>
    <dbReference type="OrthoDB" id="288203at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
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    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008271">
        <property type="term" value="F:secondary active sulfate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015116">
        <property type="term" value="F:sulfate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902476">
        <property type="term" value="P:chloride transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902358">
        <property type="term" value="P:sulfate transmembrane transport"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="CDD" id="cd07042">
        <property type="entry name" value="STAS_SulP_like_sulfate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.750.24:FF:000024">
        <property type="entry name" value="Sulfate permease 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="entry name" value="STAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018045">
        <property type="entry name" value="S04_transporter_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001902">
        <property type="entry name" value="SLC26A/SulP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00815">
        <property type="entry name" value="sulP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11814">
        <property type="entry name" value="SULFATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01130">
        <property type="entry name" value="SLC26A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="255"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="284"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="380"/>
            <end position="396"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="417"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="475"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="STAS" evidence="7">
        <location>
            <begin position="567"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="601"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="732"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="753"/>
            <end position="762"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBF84130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="827" mass="90576" checksum="AB1DAEFC9629E35A" modified="2005-04-26" version="1">MPGDIPTKVGHGLAKVLRLKLPEKPQPDAVTRGESTFSVGTFDTYSYVEPEPTAAEWFAEITPSWKEIGLYFYRLFPFLSWITRYNTTWLIGDLVAGITVGAVVVPQGMAYAQLAQLPVEYGLYSSFMGVLIYWFFATSKDITIGPVAVMSTLVGNIVTEAAETLPDVEPHVIASCLAVICGGIVTFMGLARLGFIVDFIPLPAITAFMTGSAINICSGQVSTMLGETDKVNTRGATYNTIIQTLRALPSSTLDAAMGVTACAMLYIIRFACNTAAKKQPHRAKMWFFISTLRTVFVILFYTMISAATNLHRRDNPAFKVLGTVPRGFKHAAVPTVNAEIIKTFASELPAAVIVLLIEHIAISKSFGRVNNYTIDPSQELVAIGVTNLLGPFLGGYPATGSFSRTAIKSKAGVRTPLAGVITAVVVLLAIYALPALFWYIPKASLAGVIIHAVGDLITPPNVVYQFYRVSPLDCVIFFVGVIVTVFTSIEIGVYCTVCISVAVLLFRVAKARGEFLGRVTIHSVVGDHVLEESKPGLGDADRTRSIFLPLNHADGSNPEIEIEQPYPGIFIYRFSEGFNYPNANHYTDYLVETIFQKTRRTNPFTYSNPGDRPWNNPGPRKGKQEEDRSHLPTLRAVILDFSSVNNVDVTSVQNLIDVRNQLDIYASPHTVQWHFAHVKNRWTKRALAAAGFGYPTPQSEDGFHRWKPIFSVTEIEGQSSAAAHAEIVANENTRQASSHGHDLESGIKNPSHTAERETHGIEESSNSSIGEDDKLQRDLKDSKAYQNRRKMAVVQGVNLPFFHIDITSALESALANSQEEPADVSSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="99" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BA17</accession>
    <accession>C8VKN5</accession>
    <name>Q5BA17_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS multidrug transporter, putative (AFU_orthologue AFUA_7G00230)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ANIA_02613</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF87203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_660217.1">
        <property type="nucleotide sequence ID" value="XM_655125.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BA17"/>
    <dbReference type="GeneID" id="2874656"/>
    <dbReference type="KEGG" id="ani:ANIA_02613"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_1_2_1"/>
    <dbReference type="InParanoid" id="Q5BA17"/>
    <dbReference type="OMA" id="NFWLLII"/>
    <dbReference type="OrthoDB" id="5296287at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF153">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G00230)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="295"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="338"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="377"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="402"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="470"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="82"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBF87203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="506" mass="54762" checksum="66468E1A7F5BE9D7" modified="2005-04-26" version="1">MEGKASNSESTTPGQSISQLPQQGISLTPTLAEVPKAECSEKGTATEGPLTTDDDDSEMVKWDGESDPELPVNWQPSKKWQNVVMVSALTFVTPFASSMFAPAINQVMAEMGTSNRDIGSFAVSIYLLGYAFGPLVLGPCSELYGRLIVYHTGALLFILCNVACALSVSMPMLIIFRFLTGLIGAAPLTIGPGTVADCFRQEERGRAMAVWTMPVLLGPCLGPAVGAYVSRSLGWRWNFWLLIIVRETHPPTLLKRKAARLRKSTGNPNIRPVNHTTVSRSQLITTSIVRPIRMLFLSPVVFGLSLLTAVAYGTLYLLFTTVTDVFASRYGIATNVGLIYLGCGCGQFAGLLILGLVSDAIVKRAAQGGEMKPEYRLPPTIFGGSMIPIGLLIYGWTAEYRVFWFVPVMGTFFIGLGMITVFTPVGTYLIDAFPMYAASATAANTVFRSVGGALLPLAGPRMYSTLGQGWGNTLLAGISLLMMGMIFLSLQYGERLRTHPKYQIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BAI6</accession>
    <accession>C8VP10</accession>
    <name>Q5BAI6_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_02444</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF86865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_660048.1">
        <property type="nucleotide sequence ID" value="XM_654956.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BAI6"/>
    <dbReference type="GeneID" id="2874701"/>
    <dbReference type="KEGG" id="ani:ANIA_02444"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN2444"/>
    <dbReference type="HOGENOM" id="CLU_1906715_0_0_1"/>
    <dbReference type="InParanoid" id="Q5BAI6"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF86865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="133" mass="15042" checksum="9BFE6FBF035759F9" modified="2005-04-26" version="1">MSPVFQRFRQPAPQPNSGHGLQAYLMVIFVTLVMVSDLVSWVFYVVHTGWILYQYLDNLVLGGDGPLQILFSKWDLVLSALMTARLGMLAYGFLRKRVRPWAWGHWMFGYWAGLVQAAGLTGEGSDSVSVRFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="119" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BAM0</accession>
    <accession>C8VNX0</accession>
    <name>Q5BAM0_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Translation initiation factor eIF-2B subunit family protein (AFU_orthologue AFUA_2G14290)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ANIA_02410</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the eIF-2B alpha/beta/delta subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF86791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_660014.1">
        <property type="nucleotide sequence ID" value="XM_654922.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BAM0"/>
    <dbReference type="STRING" id="227321.Q5BAM0"/>
    <dbReference type="GeneID" id="2874606"/>
    <dbReference type="KEGG" id="ani:ANIA_02410"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN2410"/>
    <dbReference type="eggNOG" id="ENOG502SIEX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021101_1_0_1"/>
    <dbReference type="InParanoid" id="Q5BAM0"/>
    <dbReference type="OMA" id="NTYFEWV"/>
    <dbReference type="OrthoDB" id="206213at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046523">
        <property type="term" value="F:S-methyl-5-thioribose-1-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd18872">
        <property type="entry name" value="NUDIX_eIF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10470:FF:000032">
        <property type="entry name" value="Translation initiation factor eIF-2B subunit family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="entry name" value="Translation initiation factor eif-2b, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43475">
        <property type="entry name" value="METHYLTHIORIBOSE-1-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43475:SF3">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_2G14290)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="3">
        <location>
            <begin position="13"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBF86791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="548" mass="61145" checksum="7AB9374151984734" modified="2005-04-26" version="1">MAGQISGVGQGLERRSVVSSFIFHLPTSLSDQPLVALFKRSDKVSTYKNHIAPISGTISRNDKDALTAAWRELSEETGINPSSATFWRTGKPFSFVDESINREWTIYPFAFQLKGTAVGSRRDSAVELDWEHEGWEWYNPTDVLIGNGLQGKGKEVPHLRESLRRVWPEGELNSKAGKALRRGLEKLQNDHESGSHELTSVALGVFRDVVKHMPDGMGGAKWWEDLQMIAWHIVKNGRESMGAATLNALLAILEEMEEIWRLETGRIDSDAGWKLERMLTIIDHHLKSRMSRAGLVKDMFAAYVRDHFLPDGKPRDKLTILTLSASSTIRDSIIEAFASLEIATLELRVLESRPLFEGVSISSSILSKFKTQCKEPSKHLNITIYTDAAAAIAANDVDMVLLGADRISISKGVSNKTGSLPAVLCAKHVSPKVKIVVLSELEKVNGNNGVIDDAKHEDNDPAELIRPWQNEGVKGLRAIEEGFHSTVRVEKSNHSIEVRNVYFEWIPLDMVDGFVSGEGVLNHWSINEKAKQQDELAKRYFGSISLRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BB71</accession>
    <accession>C8VMK0</accession>
    <name>Q5BB71_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HPP family protein (AFU_orthologue AFUA_5G07010)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_02209</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF86388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_659813.1">
        <property type="nucleotide sequence ID" value="XM_654721.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BB71"/>
    <dbReference type="STRING" id="227321.Q5BB71"/>
    <dbReference type="GeneID" id="2874823"/>
    <dbReference type="KEGG" id="ani:ANIA_02209"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN2209"/>
    <dbReference type="eggNOG" id="ENOG502S3SU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040397_0_1_1"/>
    <dbReference type="InParanoid" id="Q5BB71"/>
    <dbReference type="OMA" id="PLYWWTS"/>
    <dbReference type="OrthoDB" id="2016548at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015112">
        <property type="term" value="F:nitrate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015706">
        <property type="term" value="P:nitrate transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007065">
        <property type="entry name" value="HPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058581">
        <property type="entry name" value="TM_HPP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33741">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN DDB_G0269096-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33741:SF5">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN DDB_G0269096-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04982">
        <property type="entry name" value="TM_HPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="HPP transmembrane region" evidence="2">
        <location>
            <begin position="68"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF86388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="307" mass="33971" checksum="8C769C15EF8739EC" modified="2005-04-26" version="1">MTGNLNRDRDAAREHSSQHSRIDFARWHLDIDAVLNRFIPPPPWHLLPRPVSHFLGYRGNKPQKALGNLVIAFWSLIGVFCGVLLISEVSLRVPAFQNHHAPIIVGSFGAAAVLEFSAIESPFAQPRNALFSQVIASVIGIGISKLFALNPSAQSKPEIAGSLACAITTMAMVLTNTVHPPAGATALLAATELHPVGWWLIPVMLLGCSLMLTAAMLLNNIQRRFPVYWWTPHPLSKEAKAKKQLQDIENAPKIKQESESSSSSDFEFSEPMQVVIRPGKVEWSDNLWLDADEKEVLERISERMKHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="102" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BBK2</accession>
    <accession>C8VLQ5</accession>
    <name>Q5BBK2_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Mediator of RNA polymerase II transcription subunit 13</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Mediator complex subunit 13</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">ANIA_02078</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="17">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 11">Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the SRB8-11 complex, which itself associates with the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the Mediator complex subunit 13 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF86133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_659682.1">
        <property type="nucleotide sequence ID" value="XM_654590.1"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5BBK2"/>
    <dbReference type="GeneID" id="2874919"/>
    <dbReference type="KEGG" id="ani:ANIA_02078"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN2078"/>
    <dbReference type="eggNOG" id="KOG3600">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002210_0_0_1"/>
    <dbReference type="InParanoid" id="Q5BBK2"/>
    <dbReference type="OMA" id="DRCTLFG"/>
    <dbReference type="OrthoDB" id="103819at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
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    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009401">
        <property type="entry name" value="Med13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051139">
        <property type="entry name" value="Mediator_complx_sub13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021643">
        <property type="entry name" value="Mediator_Med13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041285">
        <property type="entry name" value="MID_MedPIWI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48249">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48249:SF3">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06333">
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    <dbReference type="Pfam" id="PF11597">
        <property type="entry name" value="Med13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18296">
        <property type="entry name" value="MID_MedPIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0010">Activator</keyword>
    <keyword evidence="8 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0678">Repressor</keyword>
    <keyword evidence="7 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 11" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Mediator complex subunit Med13 N-terminal" evidence="14">
        <location>
            <begin position="1"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="MID" evidence="15">
        <location>
            <begin position="955"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="domain" description="Mediator complex subunit Med13 C-terminal" evidence="13">
        <location>
            <begin position="1133"/>
            <end position="1447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="131"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="400"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="523"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="707"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="893"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1288"/>
            <end position="1330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="400"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="412"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="523"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="556"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019618"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025661"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU364134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF06333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF11597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF18296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CBF86133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="1458" mass="158786" checksum="8198E15BEF8ED62E" modified="2005-04-26" version="1">MDFPGGCITNVRVIDGFSNVYWRIYTEDTSGTNPPGDGPNNGHTLLKHISRLKELELRLRSQGSLVLIYPRRLGLLIFSATPDFEHLAPVLLSESGDQTNRLLVGSTILKVWTSGSVSAADLAKSHLSDLQTTNANSPAPSQRLQNNSVQPRRADNSGGSAAIYASFISAVTAAFSLQIVRQNNAIPLGPRTLFNTVNGNLDDGQGPAGNGSTSVSALTSLHVQLTSAGKLTIALQTIAQTGLLRLSQPEESASAILPGADLWLAPTGSIARLITSHSEKNSHSRPTSASEDIRRWQLNVLEWLGYFGLPTEPVTDDGWVEVEVWEPFYSRLSGEAARLKEENSSLPLKRILWPAIYCFRRSKSNQSETLDRTGESFPFLCDPLDFAEGWCAKEIPKAVETKSELPSKNQERQVNSQDTSSPGPVGLPEGIESLSRASLHPEVQSANLVYPTPPDGTAGIGLNPVVPTTTKNALDPDTTMDFGPAAGLGVGSGLYDTNEDDDLFGDMNEKDFGTKGITDADFSFFDDQNFDQPSNGGNMEDIQESPGFIESNKPDVPLGPSDLVSSSPVSVDRNNTPKGSLEQIHPAPVPHGQPLSVNDALVLSPHQDHAQTASPPLSPVEVKKILFPESSTSPKSLAKTSNALSHYSPVAFKSNISSWDQKYGADGKFSFMGVRTAFNHDPHTSSDGIPTIGLPRRKSHMKALAYSKKADAEGSPVDEVDSASSPDSESESDDGCDNTGPENTMPYMTLTTLKRKRAVSSPINSPKPSSVMSSIGAEQEVNMPRSEDSIFIGNFLSIFSDLSIAGFFTLSENHIFPSLASREIQVQVAQLLVDQVTQSSLDHKIDGRFSVSCLDNQPSWSRELLEGSEYLGGIEKLDLNSFVSLQEQNAQNFLSPDAGPAPRQNLQHKDTGRGSITKLSPPHLRVRRGKDFLETLPPAISFWETFDLEPAHGPKDITAYCIHPQFSTRAANVFLDRLGLLYPSCNLGSHSRGENIDACRNGLVEWDVKSVKRPNYQTAVQQLKLICEELGTALLDGMPSKDNIVVYIINPFSHAASLVDICAAFWTLLQNYFASAEKPPKQVDEVLLQIVPLDFVMSAESLVVPPQAEYLNLALEVYSRCSTRQMQPSLVNCAPPVMLAETLPPSIGFRLASERFSPLQEGRCLHVACSRSQDQRWMTVAWSDNSGALQRTMSYCLRFRNSTASRTLSAVRSEIWAATRDIMDKSQGRWRVIIVNTDNVDQDEYDTWLNLADQYNKSRSMAIELAILSVNTAFDISLSPPPSPLSMSLLNPQASSTPIATPVPSGSILSPDGPGNAPTPPSGANAANNALTPTDSLLESESESLLVDICDESWCVLLSHRLNGNLHLTEYRPALASGYLVRRRGTTDADGAYTMNVNLLFTQRPSTHYETTLREIIGMYRDLATLARVRGTRIVQTGTLPWHIATAMRAQEILSYVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="113" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BBN5</accession>
    <accession>C8VLM1</accession>
    <name>Q5BBN5_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="13">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">ANIA_02045</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in the maturation of Asn-linked oligosaccharides. Progressively trims alpha-1,2-linked mannose residues from Man(9)GlcNAc(2) to produce Man(5)GlcNAc(2).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasmic vesicle lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 13">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="13"/>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF86071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_659649.1">
        <property type="nucleotide sequence ID" value="XM_654557.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BBN5"/>
    <dbReference type="FunCoup" id="Q5BBN5">
        <property type="interactions" value="99"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5BBN5"/>
    <dbReference type="CAZy" id="GH47">
        <property type="family name" value="Glycoside Hydrolase Family 47"/>
    </dbReference>
    <dbReference type="GeneID" id="2875775"/>
    <dbReference type="KEGG" id="ani:ANIA_02045"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN2045"/>
    <dbReference type="eggNOG" id="KOG2431">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003818_0_0_1"/>
    <dbReference type="InParanoid" id="Q5BBN5"/>
    <dbReference type="OMA" id="WRMFKNI"/>
    <dbReference type="OrthoDB" id="8118055at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060205">
        <property type="term" value="C:cytoplasmic vesicle lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000037">
        <property type="entry name" value="alpha-1,2-Mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050749">
        <property type="entry name" value="Glycosyl_Hydrolase_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742:SF49">
        <property type="entry name" value="ALPHA-1,2-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="7 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="320"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="436"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="503"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="589"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="393"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CBF86071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="598" mass="68698" checksum="A56407B747D74158" modified="2005-04-26" version="1">MLLIKKRYALPTFILTFLIYLVFTTLPPGAEKTYIEHYSQPAHDITEIAKDNRIHWTKHAEQYPIADYISLPTASPAPIPKIQYDFPAESWFARIWRKRKQGAVKEAFKHAWKGYKSNAWLRDELSPLSGGYRTSFAGWAATLVDALDTLIIMDLTDEFEEALEALEHIDFSTTDSIQINVFETNIRYLGGLLGAHDLTEGRYPILLKKATEIADFLYGSFDTRNRMPQSRWEWTRSASGQTIHPSGNTILAELGSLNLEFTRMSQLTGDQKYFDAIQRISDHLESAQKETLVPGLWPMMVDAESMRFSDPRYTIGGMADSAYEYLPKEHMLLEGRTQQYQRMYESAIPAIKERMLFRPMTKGGEDILFSGNIYAGTKASRKKVEAQAEHLKCYLGGTIGIGAKVFNRPEELSIARKLTDGCIWAYDIMPSGIMPEVMYLSPCDDLENCPWDEQKWYRDVRARPPPHANIADTEEAAKLLIEKFDLVPGVAEIADARYMLRPEAIESVFIMYRITGDKKYQDAAWRMFNSIEKATRTKYAHAAINDVREEKPKQLDYMESFWLAETLKYFYLIFSEPELISLDDYVLNTEAHPFKRPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="123" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BC13</accession>
    <accession>C8VKT9</accession>
    <name>Q5BC13_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">ANIA_01917</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF85823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_659521.1">
        <property type="nucleotide sequence ID" value="XM_654429.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BC13"/>
    <dbReference type="GeneID" id="2874901"/>
    <dbReference type="KEGG" id="ani:ANIA_01917"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN1917"/>
    <dbReference type="eggNOG" id="KOG0759">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_14_1_1"/>
    <dbReference type="InParanoid" id="Q5BC13"/>
    <dbReference type="OMA" id="TLWRGAI"/>
    <dbReference type="OrthoDB" id="756301at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000009">
        <property type="entry name" value="Mitochondrial 2-oxoglutarate/malate carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050391">
        <property type="entry name" value="Mito_Metabolite_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45618">
        <property type="entry name" value="MITOCHONDRIAL DICARBOXYLATE CARRIER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="184"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="21"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="122"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="221"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CBF85823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="314" mass="33943" checksum="32538721E91C39C8" modified="2005-04-26" version="1">MASTTKESAKPAVDFLHHPYTRAALPFINGGLAGMTATVVIQPIDMIKVRLQLAGEGVRTGPRPSALGVARNIIASGKVLDLYTGLSAGLLRQAVYTTARLGFFDTFMKALTKNADTANRKVTFAERAGAGLTAGGIAAMIGNPADLALVRMQSDGLKPPEARAHYRSVIDALFRISKAEGVTALWAGAFPTVVRAMALNLGQLAFFAESKAQLKTRTSLSAQNQTFAASAIAGFFASFLSLPFDFVKTRLQKQQKDPKTGQLPYKGMFDCARKVVRDEGWLRFYRGFGTYYVRIAPHAMVTLIVADYLNLITK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="123" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BDB1</accession>
    <accession>C8VME0</accession>
    <name>Q5BDB1_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DnaJ domain protein (AFU_orthologue AFUA_8G04610)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ANIA_01469</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HscB family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF84923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_659073.1">
        <property type="nucleotide sequence ID" value="XM_653981.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BDB1"/>
    <dbReference type="FunCoup" id="Q5BDB1">
        <property type="interactions" value="336"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5BDB1"/>
    <dbReference type="GeneID" id="2875153"/>
    <dbReference type="KEGG" id="ani:ANIA_01469"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN1469"/>
    <dbReference type="eggNOG" id="KOG3192">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068529_1_0_1"/>
    <dbReference type="InParanoid" id="Q5BDB1"/>
    <dbReference type="OMA" id="TVELKYW"/>
    <dbReference type="OrthoDB" id="448954at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044571">
        <property type="term" value="P:[2Fe-2S] cluster assembly"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051259">
        <property type="term" value="P:protein complex oligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000173">
        <property type="entry name" value="DnaJ domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.20:FF:000006">
        <property type="entry name" value="DnaJ domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.20">
        <property type="entry name" value="HscB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004640">
        <property type="entry name" value="HscB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036386">
        <property type="entry name" value="HscB_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009073">
        <property type="entry name" value="HscB_oligo_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00714">
        <property type="entry name" value="hscB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14021">
        <property type="entry name" value="IRON-SULFUR CLUSTER CO-CHAPERONE PROTEIN HSCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14021:SF15">
        <property type="entry name" value="IRON-SULFUR CLUSTER CO-CHAPERONE PROTEIN HSCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07743">
        <property type="entry name" value="HSCB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47144">
        <property type="entry name" value="HSC20 (HSCB), C-terminal oligomerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="93"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBF84923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="279" mass="30675" checksum="F95673500526CF1D" modified="2005-04-26" version="1">MATSLRAQRAFQRLTVSSTVQSQARPIHTTTRKLSTPTACFLCRLRPSRPNRRTSAIFPSALFAQRTFTSTPSTLNSASSETLPVPNAPDTTNYYTIFPQTLPNGPPPSSPFTIDVQALRREFFSLQNTLHPDKYPPGPTKTAAESLSAIINEAYRTLSDPLLRAQYLLREFHGIDVTAEDGSGAGAQPLDPELLMEVMDVQEAIEEVGEGQEAVEKIAVMKKENDERVKGCVQALAEAFDKGDVEGARGECVRLKFWVSVADGLREWEPGMGGIRLIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="102" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BDJ0</accession>
    <accession>C8VRN2</accession>
    <name>Q5BDJ0_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Iron/copper transporter Atx1, putative (AFU_orthologue AFUA_1G08880)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ANIA_01390</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the ATX1 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF87590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_658994.1">
        <property type="nucleotide sequence ID" value="XM_653902.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BDJ0"/>
    <dbReference type="FunCoup" id="Q5BDJ0">
        <property type="interactions" value="580"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5BDJ0"/>
    <dbReference type="GeneID" id="2877168"/>
    <dbReference type="KEGG" id="ani:ANIA_01390"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN1390"/>
    <dbReference type="eggNOG" id="KOG1603">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_134973_3_1_1"/>
    <dbReference type="InParanoid" id="Q5BDJ0"/>
    <dbReference type="OMA" id="MTHTYKF"/>
    <dbReference type="OrthoDB" id="689350at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016531">
        <property type="term" value="F:copper chaperone activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006825">
        <property type="term" value="P:copper ion transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000008">
        <property type="entry name" value="Copper transport protein ATOX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051881">
        <property type="entry name" value="Copper_transport_ATOX1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017969">
        <property type="entry name" value="Heavy-metal-associated_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46365">
        <property type="entry name" value="COPPER TRANSPORT PROTEIN ATOX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46365:SF1">
        <property type="entry name" value="COPPER TRANSPORT PROTEIN ATOX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="HMA, heavy metal-associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HMA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="3" id="KW-0187">Copper transport</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="HMA" evidence="8">
        <location>
            <begin position="5"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBF87590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="81" mass="8567" checksum="8F4594BD40970CFD" modified="2005-04-26" version="1">MSDQEHHYKFNVSMSCGGCSGAVERVLKKLDGVKSFDVNLDSQTASVVTDASVPYETVLATIKKTGKTVNAGEADGEAKDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BDX8</accession>
    <accession>C8VSI9</accession>
    <name>Q5BDX8_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Carboxymuconolactone decarboxylase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_01252</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF87851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_658856.1">
        <property type="nucleotide sequence ID" value="XM_653764.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BDX8"/>
    <dbReference type="STRING" id="227321.Q5BDX8"/>
    <dbReference type="GeneID" id="2877030"/>
    <dbReference type="KEGG" id="ani:ANIA_01252"/>
    <dbReference type="eggNOG" id="ENOG502RYNJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070025_3_2_1"/>
    <dbReference type="InParanoid" id="Q5BDX8"/>
    <dbReference type="OMA" id="FTEEFQD"/>
    <dbReference type="OrthoDB" id="104509at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052512">
        <property type="entry name" value="4CMD/NDH-1_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003779">
        <property type="entry name" value="CMD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33570">
        <property type="entry name" value="4-CARBOXYMUCONOLACTONE DECARBOXYLASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33570:SF2">
        <property type="entry name" value="CARBOXYMUCONOLACTONE DECARBOXYLASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02627">
        <property type="entry name" value="CMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxymuconolactone decarboxylase-like" evidence="2">
        <location>
            <begin position="59"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF87851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="157" mass="17251" checksum="A7A2ABD7940137E6" modified="2005-04-26" version="1">MSAQNEPQAEAQSPSSGEEGSSPLGSSLYQTGLQTRQSVLGSAHVNRSLSNSNAFTFPMQEAITEFAWGSIWNRPGLDRKQRSLMNIGILIALNRQLELGVHVRGAVRNGLSELEIREAVMHTLVYCGAPAAMEGMRTVDKVLEELEREGEIKRELK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-12-20" modified="2026-01-28" version="120" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BFG0</accession>
    <accession>C8VRB9</accession>
    <name>DPH5_EMENI</name>
    <protein>
        <recommendedName>
            <fullName>Diphthine methyl ester synthase</fullName>
            <ecNumber>2.1.1.314</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Diphthamide biosynthesis methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">dph5</name>
        <name type="ORF">AN0720</name>
    </gene>
    <organism>
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">S-adenosyl-L-methionine-dependent methyltransferase that catalyzes four methylations of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine methyl ester. The four successive methylation reactions represent the second step of diphthamide biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + 4 S-adenosyl-L-methionine = diphthine methyl ester-[translation elongation factor 2] + 4 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:42652"/>
            <dbReference type="Rhea" id="RHEA-COMP:9749"/>
            <dbReference type="Rhea" id="RHEA-COMP:10173"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73995"/>
            <dbReference type="ChEBI" id="CHEBI:79005"/>
            <dbReference type="EC" id="2.1.1.314"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text>Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the diphthine synthase family.</text>
    </comment>
    <comment type="sequence caution" evidence="3">
        <conflict type="erroneous gene model prediction">
            <sequence resource="EMBL-CDS" id="EAA65197" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EC" id="2.1.1.314"/>
    <dbReference type="EMBL" id="AACD01000011">
        <property type="protein sequence ID" value="EAA65197.1"/>
        <property type="status" value="ALT_SEQ"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF88920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BFG0"/>
    <dbReference type="SMR" id="Q5BFG0"/>
    <dbReference type="FunCoup" id="Q5BFG0">
        <property type="interactions" value="919"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5BFG0"/>
    <dbReference type="EnsemblFungi" id="CBF88920">
        <property type="protein sequence ID" value="CBF88920"/>
        <property type="gene ID" value="ANIA_00720"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AN0720"/>
    <dbReference type="eggNOG" id="KOG3123">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066040_1_0_1"/>
    <dbReference type="InParanoid" id="Q5BFG0"/>
    <dbReference type="OMA" id="HNASIMS"/>
    <dbReference type="OrthoDB" id="2516at2759"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141133">
        <property type="term" value="F:diphthine methyl ester synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="CDD" id="cd11647">
        <property type="entry name" value="DHP5_DphB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.950.10:FF:000004">
        <property type="entry name" value="Diphthine synthase putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1010.10:FF:000004">
        <property type="entry name" value="Putative diphthine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="entry name" value="Cobalt-precorrin-4 Transmethylase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="entry name" value="Methyltransferase, Cobalt-precorrin-4 Transmethylase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01084">
        <property type="entry name" value="Diphthine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004551">
        <property type="entry name" value="Dphthn_synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00522">
        <property type="entry name" value="dph5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10882:SF0">
        <property type="entry name" value="DIPHTHINE METHYL ESTER SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10882">
        <property type="entry name" value="DIPHTHINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036432">
        <property type="entry name" value="Diphthine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="Tetrapyrrole methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000156141" description="Diphthine methyl ester synthase">
        <location>
            <begin position="1"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="112"/>
            <end position="113"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="P32469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="285" mass="31602" checksum="9C139CFD95BD19D1" modified="2005-12-20" version="2">MLYLVGLGLADERDITVRGLEVVKKAERVYLEAYTAILLVDKAKLEAFYGRPVIEADRELVETGSDDILANADKVDVAFLVVGDPFGATTHTDLVLRARELGIESKVIPNASIMSGIGCTGLQLYNFGQTVSMVFFTETWKPSSYYDRVKENVQIGLHTLVLLDIKVKEQSLENMARGRLIYEPPRFMTVAQCAAQMLETEEERQEGVWGPDSLAVGAARVGAEDQKLVAGTLQELTQVDMGRPLHSLVLLGRRAHDLEKDYIRRFAVDEATFDAAWQNGKYGSS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-09-19" modified="2026-01-28" version="107" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BFH3</accession>
    <accession>C8VRD3</accession>
    <name>XRN2_EMENI</name>
    <protein>
        <recommendedName>
            <fullName>5'-3' exoribonuclease 2</fullName>
            <ecNumber>3.1.13.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">rat1</name>
        <name type="ORF">AN0707</name>
    </gene>
    <organism>
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 3">Possesses 5'-&gt;3' exoribonuclease activity (By similarity). Required for the processing of nuclear mRNA and rRNA precursors. May promote the termination of transcription by RNA polymerase II (By similarity). Essential for vegetative cell growth and chromosome segregation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Interacts with rai1; the interaction is direct, stabilizes rat1 protein structure and may stimulate its exoribonuclease activity (By similarity). The interaction also stimulates rai1 pyrophosphohydrolase activity, probably by recruiting it to mRNA substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the 5'-3' exonuclease family. XRN2/RAT1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.-"/>
    <dbReference type="EMBL" id="AACD01000010">
        <property type="protein sequence ID" value="EAA65483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF88946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_658311.1">
        <property type="nucleotide sequence ID" value="XM_653219.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BFH3"/>
    <dbReference type="SMR" id="Q5BFH3"/>
    <dbReference type="FunCoup" id="Q5BFH3">
        <property type="interactions" value="1040"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5BFH3"/>
    <dbReference type="EnsemblFungi" id="CBF88946">
        <property type="protein sequence ID" value="CBF88946"/>
        <property type="gene ID" value="ANIA_00707"/>
    </dbReference>
    <dbReference type="GeneID" id="2876473"/>
    <dbReference type="KEGG" id="ani:ANIA_00707"/>
    <dbReference type="eggNOG" id="KOG2044">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006038_1_1_1"/>
    <dbReference type="InParanoid" id="Q5BFH3"/>
    <dbReference type="OMA" id="ITHDMVV"/>
    <dbReference type="OrthoDB" id="28245at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004534">
        <property type="term" value="F:5'-3' RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051984">
        <property type="term" value="P:positive regulation of chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0180037">
        <property type="term" value="P:rapid tRNA decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18673">
        <property type="entry name" value="PIN_XRN1-2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.1050:FF:000002">
        <property type="entry name" value="5'-3' exoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12390:FF:000003">
        <property type="entry name" value="5'-3' exoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12390:FF:000005">
        <property type="entry name" value="5'-3' exoribonuclease 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12390">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027073">
        <property type="entry name" value="5_3_exoribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041412">
        <property type="entry name" value="Xrn1_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004859">
        <property type="entry name" value="Xrn1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017151">
        <property type="entry name" value="Xrn2/3/4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12341:SF41">
        <property type="entry name" value="5'-3' EXORIBONUCLEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12341">
        <property type="entry name" value="5'-&gt;3' EXORIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17846">
        <property type="entry name" value="XRN_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03159">
        <property type="entry name" value="XRN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037239">
        <property type="entry name" value="Exonuclease_Xrn2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-0269">Exonuclease</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0507">mRNA processing</keyword>
    <keyword id="KW-0540">Nuclease</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0698">rRNA processing</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <keyword id="KW-0806">Transcription termination</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <keyword id="KW-0863">Zinc-finger</keyword>
    <feature type="initiator methionine" description="Removed" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000249925" description="5'-3' exoribonuclease 2">
        <location>
            <begin position="2"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CCHC-type" evidence="5">
        <location>
            <begin position="267"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="416"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="543"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="861"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="120"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="406"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="416"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="563"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="910"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="961"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="1005"/>
            <end position="1015"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="P40848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="3">
        <source>
            <dbReference type="UniProtKB" id="Q02792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="4"/>
    <evidence type="ECO:0000255" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="7"/>
    <sequence length="1032" mass="115795" checksum="7E5F419573EE6E6D" modified="2007-01-23" version="3">MGVPALFRWLSKKYPKIISSVIEELPQEVNGEEIPVDITGPNPNGEEMDNLYLDMNGIVHPCTHPEGKPPPANEQEMMIEIFKYTDRVVNMVRPRKLLMIAVDGVAPRAKMNQQRARRFRSAQEAREQDEKKQEFQRMLAKQNGDKEQMLQEEVIQKTWDSNVITPGTPFMDILAASLRYWIAYKLNTDPAWEKLKIIISDATVPGEGEHKIMEFIRSQRASPEHDPNARHVIYGLDADLIMLGLATHEPHFRVLREDVFFQESKQRTCHLCGQPGHKAEECRGQAKEKNGEFDEKGKGATLKPFIWLHVSILREYLAAELYVPHQPFPFDLERALDDWVFMCFFVGNDFLPHLPSLDIREDGIDTLIAIWRDNIPLMGGYLTQDGRVDLKKAQLILQGLAKQEDAIFRRRRQAEERKLANEKRRKQEEKARNEERARKRRRSSPSYDAIESPTHAKPRSAGAAAAPPAGLELITPARGELARQTRELTHSMVVNRGNVYRANMANKSAAAVLKSKLLGGQDGQPSDDGESTAESDAQLDAAGPVLGKRKADEAEVGQLGTETPDKPEPAKADELPPDTVRLWEEGYADRYYEQKFGVDPQDKEFRHKVARAYAEGLAWVLLYYFQGCPSWTWYYPYHYAPFAADFVDIGDMELSFEKGTPFKPYEQLMGVLPASSNHAIPKVFHSLMTEPDSEIIDFYPEDFPVDLNGKKFAWQGVVLLPFIDEKRLLAAMSKKYPLLTEDEKARNTVGRDVLLLSESHPLYQDLVSNFYSKKQGAPKYKLNMRVSDGLAGKVEKNEAYIPHSSLVSSLEEYGMPSLEDDRSIMVNYEIPKSTNIHKSMLLRGVKFGPPALDNADIQATKSRAQHSGRSYGGAPFRGGRGGRMNYAGDRQSHGNDRPNPFAAHLDPKFMPGANPGAPMGMPSGWVPPSGNFSRGPPPPPRGGTSYGYGSQQYGSYGGYGQQQSYQQSSHSQSDYYGRGPPAPYNNGPADYYSGRPSGYGPQESRGGGYNRGGYRGGRDTYSSSGHGGYGRY</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-04-04" modified="2026-01-28" version="119" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BFU1</accession>
    <accession>C8VSB7</accession>
    <name>DBP4_EMENI</name>
    <protein>
        <recommendedName>
            <fullName>ATP-dependent RNA helicase dbp4</fullName>
            <ecNumber>3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">dbp4</name>
        <name type="ORF">AN0589</name>
    </gene>
    <organism>
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">ATP-dependent RNA helicase required for ribosome biogenesis. Involved in the release of U14 snoRNA in pre-ribosomal complexes. Required for pre-rRNA cleavage at site A2.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Interacts with the U3 and U14 snoRNAs. Associates with pre-ribosomal complexes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text>The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DEAD box helicase family. DDX10/DBP4 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13"/>
    <dbReference type="EMBL" id="AACD01000007">
        <property type="protein sequence ID" value="EAA66688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF89171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_658193.1">
        <property type="nucleotide sequence ID" value="XM_653101.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BFU1"/>
    <dbReference type="SMR" id="Q5BFU1"/>
    <dbReference type="FunCoup" id="Q5BFU1">
        <property type="interactions" value="1007"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5BFU1"/>
    <dbReference type="EnsemblFungi" id="CBF89171">
        <property type="protein sequence ID" value="CBF89171"/>
        <property type="gene ID" value="ANIA_00589"/>
    </dbReference>
    <dbReference type="GeneID" id="2876356"/>
    <dbReference type="KEGG" id="ani:ANIA_00589"/>
    <dbReference type="eggNOG" id="KOG0343">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_26_1_1"/>
    <dbReference type="InParanoid" id="Q5BFU1"/>
    <dbReference type="OMA" id="YDKMFER"/>
    <dbReference type="OrthoDB" id="10259640at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd17941">
        <property type="entry name" value="DEADc_DDX10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025313">
        <property type="entry name" value="SPB4-like_CTE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13959">
        <property type="entry name" value="CTE_SPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01178">
        <property type="entry name" value="DUF4217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0347">Helicase</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0690">Ribosome biogenesis</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0698">rRNA processing</keyword>
    <feature type="chain" id="PRO_0000232199" description="ATP-dependent RNA helicase dbp4">
        <location>
            <begin position="1"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="79"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="3">
        <location>
            <begin position="279"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
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        <location>
            <begin position="503"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="687"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif">
        <location>
            <begin position="48"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DEAD box">
        <location>
            <begin position="201"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="8"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
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            <begin position="521"/>
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            <begin position="579"/>
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    <feature type="binding site" evidence="2">
        <location>
            <begin position="92"/>
            <end position="99"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00542"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <sequence length="812" mass="92025" checksum="0B796C65721958A3" modified="2005-04-26" version="1">MAPSNGHRNGKHAKSSNKSGNLKRKRVQEDLSSLIKRVEDLDLKAKYESFSDLPISEPTLSGLTSSHFKTLTDIQSRAISHALKGRDVLGAAKTGSGKTLAFLVPILENLYRKQWSDHDGLGALIISPTRELAIQIFEVLRKIGRYHTFSAGLVIGGKSLKEEQERLGRMNILVCTPGRMLQHLDQTAFFETYNLQMLVLDEADRIMDMGFQKTVDAIIGHLPPERQTLLFSATQTKKVSDLARLSLQDPEYVAVHEAASSATPSKLQQHYVVTPLPQKLDTLWSFIRSNLKSKTIVFMSSGKQVRFVYESFRHMQPGIPLLHLHGRQKQGGRLDITTRFSQAQHAVLFSTDVAARGLDFPAVDWVIQLDCPEDADTYIHRVGRTARYERDGRAVLFLDPSEEKGMLRRLEQKRVTVERINVRANKQQSIKNQLQNMCFKDPELKYLGQKAFISYVKSVYIQKDKETFNLKELKLDDFAASLGLPGAPRIKFIKGDDTKERKNASRATAYLTSGDEESDEEGGKKKQPKEKEVRTKYDRMFERRNQDVLAEHYSKLINDDGTIADSKNTEEADEDEDFLSVKRRFDAGDDALHAEDSSASDSDASDSEAEDHTEKKDPKVVKISDKDTLVIDSKRREKLLKSKKKLLKFKGKGTKLVYDDEGNAHELYEMEDEEAFKARGDAKEQQARFLAEEAARTQRADMEDKEIAKQKRREKKEKRKARERELLAEEEREERVAQLVPFDEDEDMGDAGGYSQSSDGEEEAPRPSKRAKVEEPKAVPWYKKEAGKKNDAGEKQIQTLEDLESLATGLLG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-05-05" modified="2025-04-09" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BGR2</accession>
    <accession>C8VUD7</accession>
    <accession>Q870E3</accession>
    <name>MESA_EMENI</name>
    <protein>
        <recommendedName>
            <fullName>Protein mesA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">mesA</name>
        <name type="ORF">AN0268</name>
    </gene>
    <organism>
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Mol. Biol. Cell" volume="15" first="3658" last="3672">
            <title>MesA, a novel fungal protein required for the stabilization of polarity axes in Aspergillus nidulans.</title>
            <authorList>
                <person name="Pearson C.L."/>
                <person name="Xu K."/>
                <person name="Sharpless K.E."/>
                <person name="Harris S.D."/>
            </authorList>
            <dbReference type="PubMed" id="15155805"/>
            <dbReference type="DOI" id="10.1091/mbc.E03-11-0803"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <scope>FUNCTION</scope>
        <scope>MUTAGENESIS OF GLY-93</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <source>
            <strain>ACP21</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for the formation of actin cables at hyphal tips. Involved in establishment and maintenance of hyphal polarity axes. Stabilizes the localization of the formin sepA at sites of polarized growth.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cell cortex</location>
        </subcellularLocation>
        <text>Localizes to hyphal tips and sites of branch emergence.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the AFI1/mesA family.</text>
    </comment>
    <comment type="sequence caution" evidence="4">
        <conflict type="erroneous gene model prediction">
            <sequence resource="EMBL-CDS" id="CBF89848" version="1"/>
        </conflict>
    </comment>
    <comment type="sequence caution" evidence="4">
        <conflict type="erroneous gene model prediction">
            <sequence resource="EMBL-CDS" id="EAA66141" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EMBL" id="AY267354">
        <property type="protein sequence ID" value="AAP31022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AACD01000005">
        <property type="protein sequence ID" value="EAA66141.1"/>
        <property type="status" value="ALT_SEQ"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF89848.1"/>
        <property type="status" value="ALT_SEQ"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_657872.1">
        <property type="nucleotide sequence ID" value="XM_652780.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BGR2"/>
    <dbReference type="SMR" id="Q5BGR2"/>
    <dbReference type="STRING" id="227321.Q5BGR2"/>
    <dbReference type="KEGG" id="ani:ANIA_00268"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN0268"/>
    <dbReference type="eggNOG" id="ENOG502QQUZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009044_0_0_1"/>
    <dbReference type="InParanoid" id="Q5BGR2"/>
    <dbReference type="OrthoDB" id="66409at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030448">
        <property type="term" value="P:hyphal growth"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052809">
        <property type="entry name" value="Actin_polarity_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012860">
        <property type="entry name" value="Afi1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037516">
        <property type="entry name" value="Tripartite_DENN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28245">
        <property type="entry name" value="ARF3-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28245:SF1">
        <property type="entry name" value="ARF3-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07792">
        <property type="entry name" value="Afi1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08616">
        <property type="entry name" value="SPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50211">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000373999" description="Protein mesA">
        <location>
            <begin position="1"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="domain" description="uDENN" evidence="1">
        <location>
            <begin position="81"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="cDENN" evidence="1">
        <location>
            <begin position="361"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="dDENN" evidence="1">
        <location>
            <begin position="508"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="138"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="302"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="581"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="52"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="177"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="302"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="mutagenesis site" description="In mesA1; reduced function." evidence="3">
        <original>G</original>
        <variation>R</variation>
        <location>
            <position position="93"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; AAP31022." evidence="4" ref="1">
        <original>PL</original>
        <variation>HK</variation>
        <location>
            <begin position="133"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; AAP31022." evidence="4" ref="1">
        <original>S</original>
        <variation>T</variation>
        <location>
            <position position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="15155805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="791" mass="87985" checksum="C75724F25F3C031A" modified="2009-05-05" version="2">MSIPLPIRTSDGTGNLSSSPPKSNGLPRLSPSPSFVQKHSPRSSDTSGLRRSASHHNARQTFKQRRCKSQYPRDSPERHVEFILVASFHIDRGPIMEHQYPGPISSDEGMLAELMLPDQTHVRSQDWTIFFLPLDTGGEGEEDDLAGENNKRKGKRNRVRSSSGDEGTSADTNNESEVTEEEESSDEEDGGEGPPLMYVLNLVNTKQDNTVKRGAVVKAMAICTRHSFLHIYKPILLLALEDYFKNPYPETLETLYNAVNAMDLSPMPKLNLLERQILQATNSKDMFIEKFEQMVQQRAIEDGENDIDEDNPPSPRRGTAPRYTLPRDTHEFESKIIYNDIPIPVKVPTVIWPEIVGDFSLVKLIQIFSAPHAASPQPFPLHPHLTTSGPLTHPIIVLVNAMLTQKRVVFLGHNRPSGEVAEAVLAACALASGGILRGFTRHAFPYTDLTKIDDLLRVPGFIAGVTNPTFANHPEWWDVLCDLPTGRIKISNHIEPAPVTDGQLYFQQQSPVSASGPNADPTGDNLFMEDVLRSIANRYGENAIRAKWRAYITKFTRVAAAFEETVYGASNIYIIGPNEELSPDSPSGLQSDPGDPTTIRGHGYVWPDEASKQRELMASVSRIEGWRTTRSYYSFIQDIAAMYWPSRPIQKPDLHHHHDRLRTLKLSAYEAGAIYLAFAHAIKDYAGICQLLTVTPESQAGLFYLSMGLLHPDRNVREATADLLERIALHPAGRHFWAQLNRFAKTAYFRIKREKEAAGNSSPIVKSPSDSFGPQQSLVGVAISGVHSQGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BGZ3</accession>
    <accession>C8VUX6</accession>
    <name>Q5BGZ3_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_00187</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF90015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_657791.1">
        <property type="nucleotide sequence ID" value="XM_652699.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BGZ3"/>
    <dbReference type="GeneID" id="2875959"/>
    <dbReference type="KEGG" id="ani:ANIA_00187"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN0187"/>
    <dbReference type="HOGENOM" id="CLU_2812325_0_0_1"/>
    <dbReference type="InParanoid" id="Q5BGZ3"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF90015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="67" mass="7196" checksum="08E2DFD544BFE669" modified="2005-04-26" version="1">MKASMASSIGQIDLLPTTDYRLRWGVGDPAIQGSPRCSSRGVADSENPDTATKTQLNYPRSTATDHT</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2016-09-07" modified="2026-01-28" version="127" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BH34</accession>
    <accession>C8VQ70</accession>
    <name>MDPC_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Short chain dehydrogenase mdpC</fullName>
            <ecNumber evidence="7 9">1.3.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Monodictyphenone synthesis protein C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">mdpC</name>
        <name type="ORF">AN0146</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2010" name="Appl. Environ. Microbiol." volume="76" first="2067" last="2074">
            <title>Characterization of the Aspergillus nidulans monodictyphenone gene cluster.</title>
            <authorList>
                <person name="Chiang Y.M."/>
                <person name="Szewczyk E."/>
                <person name="Davidson A.D."/>
                <person name="Entwistle R."/>
                <person name="Keller N.P."/>
                <person name="Wang C.C."/>
                <person name="Oakley B.R."/>
            </authorList>
            <dbReference type="PubMed" id="20139316"/>
            <dbReference type="DOI" id="10.1128/AEM.02187-09"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>PATHWAY</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2011" name="J. Am. Chem. Soc." volume="133" first="4010" last="4017">
            <title>Genome-based deletion analysis reveals the prenyl xanthone biosynthesis pathway in Aspergillus nidulans.</title>
            <authorList>
                <person name="Sanchez J.F."/>
                <person name="Entwistle R."/>
                <person name="Hung J.H."/>
                <person name="Yaegashi J."/>
                <person name="Jain S."/>
                <person name="Chiang Y.M."/>
                <person name="Wang C.C."/>
                <person name="Oakley B.R."/>
            </authorList>
            <dbReference type="PubMed" id="21351751"/>
            <dbReference type="DOI" id="10.1021/ja1096682"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>PATHWAY</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2012" name="ChemBioChem" volume="13" first="1680" last="1688">
            <title>Genetic and biosynthetic studies of the fungal prenylated xanthone shamixanthone and related metabolites in Aspergillus spp. revisited.</title>
            <authorList>
                <person name="Simpson T.J."/>
            </authorList>
            <dbReference type="PubMed" id="22730213"/>
            <dbReference type="DOI" id="10.1002/cbic.201200014"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>PATHWAY</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2012" name="J. Am. Chem. Soc." volume="134" first="14742" last="14745">
            <title>Tautomers of anthrahydroquinones: enzymatic reduction and implications for chrysophanol, monodictyphenone, and related xanthone biosyntheses.</title>
            <authorList>
                <person name="Schaetzle M.A."/>
                <person name="Husain S.M."/>
                <person name="Ferlaino S."/>
                <person name="Mueller M."/>
            </authorList>
            <dbReference type="PubMed" id="22909031"/>
            <dbReference type="DOI" id="10.1021/ja307151x"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>PATHWAY</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2015" name="J. Am. Chem. Soc." volume="137" first="10867" last="10869">
            <title>New insights into the conversion of versicolorin A in the biosynthesis of aflatoxin B1.</title>
            <authorList>
                <person name="Conradt D."/>
                <person name="Schaetzle M.A."/>
                <person name="Haas J."/>
                <person name="Townsend C.A."/>
                <person name="Mueller M."/>
            </authorList>
            <dbReference type="PubMed" id="26266881"/>
            <dbReference type="DOI" id="10.1021/jacs.5b06770"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>PATHWAY</scope>
    </reference>
    <reference key="8">
        <citation type="journal article" date="2013" name="PLoS ONE" volume="8" first="e62088" last="e62088">
            <title>Identification of metabolic pathways influenced by the G-protein coupled receptors GprB and GprD in Aspergillus nidulans.</title>
            <authorList>
                <person name="de Souza W.R."/>
                <person name="Morais E.R."/>
                <person name="Krohn N.G."/>
                <person name="Savoldi M."/>
                <person name="Goldman M.H."/>
                <person name="Rodrigues F."/>
                <person name="Caldana C."/>
                <person name="Semelka C.T."/>
                <person name="Tikunov A.P."/>
                <person name="Macdonald J.M."/>
                <person name="Goldman G.H."/>
            </authorList>
            <dbReference type="PubMed" id="23658706"/>
            <dbReference type="DOI" id="10.1371/journal.pone.0062088"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="9">
        <citation type="journal article" date="2020" name="Microorganisms" volume="8" first="0" last="0">
            <title>Genome Wide Analysis Reveals the Role of VadA in Stress Response, Germination, and Sterigmatocystin Production in Aspergillus nidulans Conidia.</title>
            <authorList>
                <person name="Son Y.E."/>
                <person name="Park H.S."/>
            </authorList>
            <dbReference type="PubMed" id="32872591"/>
            <dbReference type="DOI" id="10.3390/microorganisms8091319"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="4 5 6 7 9 13">Short chain dehydrogenase; part of the gene cluster that mediates the biosynthesis of monodictyphenone, a prenyl xanthone derivative (PubMed:20139316, PubMed:21351751, PubMed:22730213, PubMed:22909031, PubMed:26266881). Within the pathway, mdpB, mdpC and mdpL are involved in modification steps after emodin (PubMed:20139316, PubMed:21351751, PubMed:22730213). This part of the pathway still requires clarification and several ways have been proposed. One path that fits best with gene deletion experiments suggests a direct reduction of emodin by mdpC followed by dehydration catalyzed by mdpB that leads to the formation of the intermediate chrysophanol in two simple steps. Subsequent Baeyer-Villiger oxidation by mdpL would give a lactone, the direct precursor of monodictyphenone (PubMed:22730213). The pathway begins with the synthesis of atrochrysone thioester by the polyketide synthase (PKS) mdpG. The atrochrysone carboxyl ACP thioesterase mdpF then breaks the thioester bond and releases the atrochrysone carboxylic acid from mdpG. The atrochrysone carboxylic acid is then converted to atrochrysone by mdpH-1 which is further transformed into emodin anthrone. The next step is performed by the anthrone oxygenase mdpH-2 that catalyzes the oxidation of emodinanthrone to emodin. Emodin is further modified to yield monodictyphenone via several steps involving mdpB, mdpC and mdpL. Mdpj and mdpK are part of a branching pathway leading to arugosin F, which is further converted to shamixanthone and epishamixanthone via several intermediates including arugosins I, H, A, B or variecoxanthone A. These reactions are performed by the FAD-dependent monooxygenase mdpD, the xanthone prenyltransferases xptA and xptB and the dehydrogenase xptC.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 9">
            <text>3,8,9,10-tetrahydroxy-6-methyl-1,4-dihydroanthracen-1-one + NADPH + H(+) = (3R)-3,8,9,10-tetrahydroxy-6-methyl-1,2,3,4-tetrahydroanthracen-1-one + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:64292"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:150020"/>
            <dbReference type="ChEBI" id="CHEBI:150021"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:64293"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="4 5 6 7 9">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="induction">
        <text evidence="8 10">Expression is negatively regulated by the gprB G-protein coupled receptor signaling pathway (PubMed:23658706). Expression is also negatively regulated by the spore-specific regulatory gene vadA in conidia (PubMed:32872591).</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="4 5 6">Impairs the production of monodictyphenone, but still enables the synthesis of intermediates until emodin.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.-" evidence="7 9"/>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF90105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="EMBL" id="AACD01000005">
        <property type="protein sequence ID" value="EAA66019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="XP_657750.1">
        <property type="nucleotide sequence ID" value="XM_652658.1"/>
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    <dbReference type="AlphaFoldDB" id="Q5BH34"/>
    <dbReference type="SMR" id="Q5BH34"/>
    <dbReference type="STRING" id="227321.Q5BH34"/>
    <dbReference type="EnsemblFungi" id="CBF90105">
        <property type="protein sequence ID" value="CBF90105"/>
        <property type="gene ID" value="ANIA_00146"/>
    </dbReference>
    <dbReference type="KEGG" id="ani:ANIA_00146"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
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        <property type="component" value="Chromosome VIII"/>
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    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="entry name" value="THN_reductase-like_SDR_c"/>
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        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
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        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
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        <property type="entry name" value="KR_dom"/>
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    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
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    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
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    <dbReference type="PANTHER" id="PTHR43639">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G02870)"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0521">NADP</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000437105" description="Short chain dehydrogenase mdpC">
        <location>
            <begin position="1"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="162"/>
        </location>
    </feature>
    <feature type="active site" description="Lowers pKa of active site Tyr" evidence="2">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="131"/>
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        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
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    <feature type="binding site" evidence="2">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="166"/>
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        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
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    <feature type="binding site" evidence="1">
        <location>
            <position position="197"/>
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        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="L0E2Z4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="O93868"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10001"/>
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            <dbReference type="PubMed" id="20139316"/>
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            <dbReference type="PubMed" id="21351751"/>
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            <dbReference type="PubMed" id="22730213"/>
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        <source>
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    </evidence>
    <evidence type="ECO:0000269" key="8">
        <source>
            <dbReference type="PubMed" id="23658706"/>
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        <source>
            <dbReference type="PubMed" id="26266881"/>
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    </evidence>
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        <source>
            <dbReference type="PubMed" id="32872591"/>
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    </evidence>
    <evidence type="ECO:0000303" key="11">
        <source>
            <dbReference type="PubMed" id="20139316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="12"/>
    <evidence type="ECO:0000305" key="13">
        <source>
            <dbReference type="PubMed" id="22730213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EAA66019.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000005890"/>
        </source>
    </evidence>
    <sequence length="265" mass="28448" checksum="4FE607E41DCD0FC7" modified="2005-04-26" version="1">MTATTHAPYRLEGKVALVTGSGRGIGAAMALELGRLGAKVVVNYANSREPAEKLVQEIKELGTDAIALQANIRNVSEIVRVMDDAVAHFGGLDIVCSNAGVVSFGHLGEVTEEEFDRVFSLNTRAQFFVAREAYRHLNTHGRIILMSSNTAKEFSVPRHSVYSGSKGAIESFVRVMAKDCGDKQITVNAVAPGGTVTDMFYDVAQHYIPNGEKHSAEELQKMAATVSPLKRNGFPVDIAKVVGFLASREAEWVNGKIITVDGGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="124" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BH43</accession>
    <accession>C8VQI6</accession>
    <name>Q5BH43_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glycerophosphocholine phosphodiesterase Gde1, putative (AFU_orthologue AFUA_5G11590)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ANIA_00137</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF90127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_652649.2"/>
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        <property type="interactions" value="165"/>
    </dbReference>
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    <dbReference type="KEGG" id="ani:ANIA_00137"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1162">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2421">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005444_1_0_1"/>
    <dbReference type="InParanoid" id="Q5BH43"/>
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    <dbReference type="OrthoDB" id="197419at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047389">
        <property type="term" value="F:glycerophosphocholine phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046475">
        <property type="term" value="P:glycerophospholipid catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd08606">
        <property type="entry name" value="GDPD_YPL110cp_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14484">
        <property type="entry name" value="SPX_GDE1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057506">
        <property type="entry name" value="C2_GPCPD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051578">
        <property type="entry name" value="GDPD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22958:SF1">
        <property type="entry name" value="GLYCEROPHOSPHOCHOLINE PHOSPHODIESTERASE GPCPD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22958">
        <property type="entry name" value="GLYCEROPHOSPHORYL DIESTER PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25329">
        <property type="entry name" value="C2_GDE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03105">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="SPX" evidence="6">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="370"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="490"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="528"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="domain" description="GP-PDE" evidence="7">
        <location>
            <begin position="817"/>
            <end position="1147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="586"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="899"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="602"/>
            <end position="637"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBF90127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="1205" mass="132964" checksum="0780846C3A8930F3" modified="2005-04-26" version="1">MKFGRNLPRNVVPEWSSSYIRYKALKKLIKSLADRVRAGHEADLAGFFYSLDRNLEDVDHFYNKKYADFSRRLKLLSDRYAHNLDGSHLDSDDVEDLLAALLELRGQFRKLQWYGEVNRRGFNKITKKLDKKVGAQAQQKYLETKVEPLPFASNTRVTEALKKINDWLSALGDQKTFDDASSTHSSLSLKRGPSRPNLNLPANTLLTIDDALRKDDTHVVLELLEDLKTVADEAGENVFPKVLRSLLQRAIHYRSKACISAVIGRSGSLEEEDDINKRNCIHRLVIAIGRAQTTTDSEQSASMVLDFPMDTPNYITPAALPTLQPPRSFAKESDHVQHLTRSDPAVSVLEYLLDHLRPDQRESLLSKDISGRTPLHYAAQYGFRVVCEVIIEHLQAWNMFDVSEGIDGPRWQDNDGWAPLHLSVVGGHPLTTQALLKAENWKGQIQDKAEIRKHVSRSSAVLALAVKANFIDIVQLLVDAKVDINYQDQQGETALHVAARFDHEKCARILLKGNDVQKADTELAESTYSWTPLFIACVDGSLSVVEALIEAGADLERLDSSGWTAKEHAALRGHLDVARCLAKVTPEPELSEEPALTVPTASGSTTSGPLSSQPQSSLMEKKSNGGSAAGSSPSRNPEPVKSFGHRYLTDEAMILVSLGTMDTRKHVHAVNLDRIPMENAHATQLDTALSIVVSANGAHGEPEIIDLPVQENISTEPIVFHAADPTKVRLLFDLVPTYSGSKDQIVGRGVALLSSVRPSVGSHRTNLQGDSTVPIVAANTLEVIGSITFNFLVITPFKHPNMSINREQTYWRSMSSTMVIGHRGLGKNFATRNSLQLGENTIQSFIAAANLGASYVEFDIQLTKDHVPVIYHDFLVSETGIDAPVHTLTLEQFLQLGERGTTRTPGSPGQIAIGGTERSKTPPLPPRHRSMSVGGTESDISELNERIKHTRDFKKKGFKGNSRGNHIQAPFATLEELFKKLPQNVGFNMELKYPMLYESEEEEMDTYAVELNSFVDTVLEKVYTLGQGRNMIFSSFNPDICLLLSFKQPSIPVLFLTDSGSSPIGDIRASSLQEAIRFASRWNLLGVVTQAECLVLCPRLIRVVKESGLVCVSYGTSNNDPHKVKLQAAEGIDAVIVDSVLAIRKGLTEHEGKNSFTPGPTPHASPLSQPTINAALKDAHRIPVLNNNTEVKDNYLQVKSDAASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>C8V019</accession>
    <name>C8V019_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein L19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ANIA_10740</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL19 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF70732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467079.1">
        <property type="nucleotide sequence ID" value="XM_050612710.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V019"/>
    <dbReference type="FunCoup" id="C8V019">
        <property type="interactions" value="962"/>
    </dbReference>
    <dbReference type="STRING" id="227321.C8V019"/>
    <dbReference type="GeneID" id="74896574"/>
    <dbReference type="KEGG" id="ani:ANIA_10740"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN10740"/>
    <dbReference type="eggNOG" id="KOG1696">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083919_0_1_1"/>
    <dbReference type="InParanoid" id="C8V019"/>
    <dbReference type="OMA" id="NRVWIDP"/>
    <dbReference type="OrthoDB" id="5407653at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01417">
        <property type="entry name" value="Ribosomal_L19e_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.240:FF:000001">
        <property type="entry name" value="Ribosomal protein L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1650.10:FF:000001">
        <property type="entry name" value="Ribosomal protein L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01475">
        <property type="entry name" value="Ribosomal_eL19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035970">
        <property type="entry name" value="60S_ribosomal_eL19_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039547">
        <property type="entry name" value="Ribosomal_eL19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023638">
        <property type="entry name" value="Ribosomal_eL19_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000196">
        <property type="entry name" value="Ribosomal_eL19_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015972">
        <property type="entry name" value="Ribosomal_eL19_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033935">
        <property type="entry name" value="Ribosomal_eL19_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057259">
        <property type="entry name" value="Ribosomal_L19e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057260">
        <property type="entry name" value="Ribosomal_L19e_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006343">
        <property type="entry name" value="PRK08570.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10722">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01280">
        <property type="entry name" value="Ribosomal_L19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25476">
        <property type="entry name" value="Ribosomal_L19e_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01416">
        <property type="entry name" value="Ribosomal_L19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48140">
        <property type="entry name" value="Ribosomal protein L19 (L19e)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00526">
        <property type="entry name" value="RIBOSOMAL_L19E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein eL19" evidence="6">
        <location>
            <begin position="3"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="154"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="154"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBF70732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="190" mass="22462" checksum="801AB2CAFE7856D4" modified="2009-11-03" version="1">MVNLRTQKRLAASVVGCGKRKIWLDPNEMSEISNANSRQTIRKLVKDGLIIRKPVTMHSRSRARELNAARRIGRHRGLGKRKGTKEARMPSSLLWMRRMRVLRRLLVRYRAAGKIDKHLYHELYHLSKGNTFKHKRALIEHIQKAKAERHRERILKEEMDAKRAKNKALRERRQERLEAKRNALVGEEQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>C8V156</accession>
    <name>C8V156_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Choline monooxygenase, chloroplastic</fullName>
            <ecNumber evidence="4">1.14.15.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ANIA_10842</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the first step of the osmoprotectant glycine betaine synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>choline + 2 reduced [2Fe-2S]-[ferredoxin] + O2 + 2 H(+) = betaine aldehyde hydrate + 2 oxidized [2Fe-2S]-[ferredoxin] + H2O</text>
            <dbReference type="Rhea" id="RHEA:17769"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15870"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="EC" id="1.14.15.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine aldehyde from choline (monooxygenase route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the choline monooxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.15.7" evidence="4"/>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF71110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467132.1">
        <property type="nucleotide sequence ID" value="XM_050613217.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V156"/>
    <dbReference type="STRING" id="227321.C8V156"/>
    <dbReference type="GeneID" id="74896634"/>
    <dbReference type="KEGG" id="ani:ANIA_10842"/>
    <dbReference type="eggNOG" id="ENOG502S0ZS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026244_0_0_1"/>
    <dbReference type="InParanoid" id="C8V156"/>
    <dbReference type="OMA" id="ARMEFDY"/>
    <dbReference type="OrthoDB" id="426882at2759"/>
    <dbReference type="UniPathway" id="UPA00529">
        <property type="reaction ID" value="UER00430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019133">
        <property type="term" value="F:choline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019285">
        <property type="term" value="P:glycine betaine biosynthetic process from choline"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00680">
        <property type="entry name" value="RHO_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.380.10">
        <property type="entry name" value="Naphthalene 1,2-dioxygenase Alpha Subunit, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015879">
        <property type="entry name" value="Ring_hydroxy_dOase_asu_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001663">
        <property type="entry name" value="Rng_hydr_dOase-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43756">
        <property type="entry name" value="CHOLINE MONOOXYGENASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43756:SF3">
        <property type="entry name" value="CHOLINE MONOOXYGENASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00848">
        <property type="entry name" value="Ring_hydroxyl_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aromatic-ring-hydroxylating dioxygenase alpha subunit C-terminal" evidence="7">
        <location>
            <begin position="151"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBF71110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="285" mass="32937" checksum="3B4B7BEFE2D4EBEC" modified="2009-11-03" version="1">MPELARTLPASWYCSQPLYQLERRAVFLKSWYLLGPLTRFQNVGEVEKTLRYHVTPTGLVFTTVSDQAPSFHEYFPELEPLLQRVDFTKLPYKRSIKYEGRFNWKTMQGPVSTCLHCQYTHPSFSIYYPPTWYEVHNHINFSQHIADPKKPDDGLFLYFFPNCTLNVYGGGMSSFRVCPTDDPGVTRMEFDYYHMESGEKFEEYYRFVRQVATEDYELCEKAQANLNKGVYREGILNPEKENGVSCESSSLVGERTKLTTFSLPGLLVRARLPTICSGGSEARGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>C8V1B0</accession>
    <name>C8V1B0_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">hydroxymethylglutaryl-CoA lyase</fullName>
            <ecNumber evidence="3">4.1.3.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ANIA_10797</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(3S)-3-hydroxy-3-methylglutaryl-CoA = acetoacetate + acetyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:24404"/>
            <dbReference type="ChEBI" id="CHEBI:13705"/>
            <dbReference type="ChEBI" id="CHEBI:43074"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="4.1.3.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Metabolic intermediate metabolism; (S)-3-hydroxy-3-methylglutaryl-CoA degradation; acetoacetate from (S)-3-hydroxy-3-methylglutaryl-CoA: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HMG-CoA lyase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.4" evidence="3"/>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF69786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050466946.1">
        <property type="nucleotide sequence ID" value="XM_050611403.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V1B0"/>
    <dbReference type="STRING" id="227321.C8V1B0"/>
    <dbReference type="GeneID" id="74896608"/>
    <dbReference type="KEGG" id="ani:ANIA_10797"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN10797"/>
    <dbReference type="eggNOG" id="KOG2368">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022138_3_0_1"/>
    <dbReference type="InParanoid" id="C8V1B0"/>
    <dbReference type="OMA" id="FQMRNTH"/>
    <dbReference type="OrthoDB" id="1905920at2759"/>
    <dbReference type="UniPathway" id="UPA00896">
        <property type="reaction ID" value="UER00863"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004419">
        <property type="term" value="F:hydroxymethylglutaryl-CoA lyase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046951">
        <property type="term" value="P:ketone body biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006552">
        <property type="term" value="P:L-leucine catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd07938">
        <property type="entry name" value="DRE_TIM_HMGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000071">
        <property type="entry name" value="Hydroxymethylglutaryl-CoA lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043594">
        <property type="entry name" value="HMGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004283">
        <property type="entry name" value="PRK05692.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42738">
        <property type="entry name" value="HYDROXYMETHYLGLUTARYL-COA LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42738:SF7">
        <property type="entry name" value="HYDROXYMETHYLGLUTARYL-COA LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="7">
        <location>
            <begin position="33"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBF69786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="353" mass="37573" checksum="3858482A4ACFBE93" modified="2009-11-03" version="1">MIKSRPGWRFLSSLRAPPTRRFATEARLTSDHVRIVEVGPRDGLQNEKKSISLETKLELISKLAKTGVTTIEAGSFVPAKWVPQMASTAEICEHLLQTPPQSLNAIAYNYLVPNVKGLEGLIKVMDATGASASTPGTKTTPPTTTEISLFAAATEAFSKANTNCTIQESLDRIRPIVALAKTKDIRVRGYVSVALGCPYEGPDVPPSKVADITATLLEMGADEVSVADTTGMGTAPRTMELLQALKAAGIANTDLALHFHDTYGQALVNTIVGLEHGVRIFDSSVGGLGGCPYSKGATGNVSTEDLVHTIHGLGMHTGIDLEEMSRIGQWISDELGRPNESRAGKATIARLQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C8V1C2</accession>
    <name>C8V1C2_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical base excision DNA repair protein (Eurofung)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_10840</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF71146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467134.1">
        <property type="nucleotide sequence ID" value="XM_050613274.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V1C2"/>
    <dbReference type="GeneID" id="74896632"/>
    <dbReference type="KEGG" id="ani:ANIA_10840"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN10840"/>
    <dbReference type="eggNOG" id="ENOG502QRUG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012862_9_3_1"/>
    <dbReference type="InParanoid" id="C8V1C2"/>
    <dbReference type="OMA" id="DGCVIDH"/>
    <dbReference type="OrthoDB" id="5607at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000702">
        <property type="term" value="F:oxidized base lesion DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="entry name" value="Helix-hairpin-Helix base-excision DNA repair enzymes (C-terminal)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47203">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47203:SF1">
        <property type="entry name" value="HYPOTHETICAL BASE EXCISION DNA REPAIR PROTEIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HhH-GPD" evidence="2">
        <location>
            <begin position="245"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF71146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="502" mass="54965" checksum="7CEF626275C209FA" modified="2009-11-03" version="1">MLPPASLYSPWFSAVSFHFPTIHGIMTRSQAARETALIAAGIEKIAPQMQDSAVGPPASQINGRVTRSKTAALQHHNPALQKEGANQLRKKKEQRKGKRKSVLIPGDVNELPHNLGFLPPLSKIEDVANGDIKTEVEEEGVDALTKELQATVNKATEVLAGPPPEDSKKKTKKPKKANTYGLTPGITPFPDWARPTPEECEEVNRLLSSIHGEIVAPTTIPEPSLTVTGCGEVPSVLDALIRTLLSGATTGNNSALAFNGLVQKFGILHDGIGKGSVNWDAVRRAPVKDVFEAIKSGGLADSKSKNIKAILDMVYKENQERRNILVKGQDTNSDSGKFVQQLNDKPEGEKQYEIACADQNFLSLNYLHGLPTEEVMTELMKYPGIGPKTAACVLLFCLQRPCFAVDTHIFRICKWLNWVPPDRATEITAFSHLEVRIPDHLKYPLHQLLIRHGKSCPRCRAITGHSSAGWEKGCVIDHLVTRTGKRKNAIEGEKGKSKRPKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>C8V263</accession>
    <name>C8V263_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter, putative (AFU_orthologue AFUA_3G11760)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ANIA_06774</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF71432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467168.1">
        <property type="nucleotide sequence ID" value="XM_050611113.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V263"/>
    <dbReference type="GeneID" id="2870302"/>
    <dbReference type="KEGG" id="ani:ANIA_06774"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN6774"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_8_0_1"/>
    <dbReference type="InParanoid" id="C8V263"/>
    <dbReference type="OMA" id="IHYLLAC"/>
    <dbReference type="OrthoDB" id="3066029at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000354">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF64">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11760)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="102"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="160"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="252"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="290"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="332"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="365"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="402"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="426"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="36"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBF71432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="457" mass="49731" checksum="FD1EB378B4D33758" modified="2009-11-03" version="1">MSLAQPEKNNGADKERGAEAPVDEFGRFSRSRKMVMTIVISWTGLLSPMASTSVLSAIPNVAATYKTTGSIIGLSNALYLVFMALSPCFWGPWCQTIGRRMSCLASTLIFLGASIGTALSPNIAAFMVFRMLTAFVGTAILVIGPAVIRDLYPPLERATGIAWFYTGTLVGPTVGPLLAGAIVTYTTWRVIFWLQTGLAAISLLGIFFLLPETLSETAPRPLKGLMRGQKVKVFFTMTNPWRVISPFKRPSLVVTAIASGSLVWNQYGLLTPIRYVLNPRFHLETPLQSGLLYLAPGCGYILGTFFGGRWADYVATRWYRHRGQVFVPEDRLYAAVPFLGIVIPACMLIYGWSVDKEFGGLPVPVIFMFFQGVSQLFCFPSLNTYCLDVVPDRSAELIAGNFFIRYIFGAVASATAIPAAESIGVGWFSTISALLLVVGGAGIFIVARWGKAKSVET</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C8V2L7</accession>
    <name>C8V2L7_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mitochondrial ATP synthase epsilon chain domain-containing protein (AFU_orthologue AFUA_2G09310)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_11499</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ATPase epsilon family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF70206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467008.1">
        <property type="nucleotide sequence ID" value="XM_050612006.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V2L7"/>
    <dbReference type="STRING" id="227321.C8V2L7"/>
    <dbReference type="GeneID" id="74897075"/>
    <dbReference type="KEGG" id="ani:ANIA_11499"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN11499"/>
    <dbReference type="eggNOG" id="KOG3495">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_187039_0_0_1"/>
    <dbReference type="InParanoid" id="C8V2L7"/>
    <dbReference type="OMA" id="NKYTQIA"/>
    <dbReference type="OrthoDB" id="269124at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042776">
        <property type="term" value="P:proton motive force-driven mitochondrial ATP synthesis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd12153">
        <property type="entry name" value="F1-ATPase_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1620.20:FF:000003">
        <property type="entry name" value="Mitochondrial ATP synthase epsilon chain domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1620.20">
        <property type="entry name" value="ATP synthase, F1 complex, epsilon subunit superfamily, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006721">
        <property type="entry name" value="ATP_synth_F1_esu_mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036742">
        <property type="entry name" value="ATP_synth_F1_esu_sf_mt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12448">
        <property type="entry name" value="ATP SYNTHASE EPSILON CHAIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12448:SF0">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT EPSILON, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04627">
        <property type="entry name" value="ATP-synt_Eps"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48690">
        <property type="entry name" value="Epsilon subunit of mitochondrial F1F0-ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF70206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="74" mass="8278" checksum="EB2726C25552793B" modified="2009-11-03" version="1">MVFAWKSAGLTYNRYLAVAARAVRRSLQDGPRLAAERRGNMDLRFAKWENGKQGEVKNLAEANDQAIAAQAEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>C8V3H9</accession>
    <name>C8V3H9_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_11495</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF70522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467044.1">
        <property type="nucleotide sequence ID" value="XM_050612417.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V3H9"/>
    <dbReference type="GeneID" id="74897071"/>
    <dbReference type="KEGG" id="ani:ANIA_11495"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN11495"/>
    <dbReference type="HOGENOM" id="CLU_2558269_0_0_1"/>
    <dbReference type="InParanoid" id="C8V3H9"/>
    <dbReference type="OrthoDB" id="4425388at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF70522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="82" mass="8927" checksum="68A5CF91E205762C" modified="2009-11-03" version="1">MPGLSKLKKRLAAIKEEWGPLMAAKEEGDEEYNFPAGGGPRPGQNSSNQTPSQKEKQPESTDSDGRTSERARRSPDLDAIAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>C8V3Q7</accession>
    <name>C8V3Q7_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Serine/threonine protein kinase (Kin28), putative (AFU_orthologue AFUA_7G03720)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">ANIA_08285</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF74278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467300.1">
        <property type="nucleotide sequence ID" value="XM_050611254.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V3Q7"/>
    <dbReference type="FunCoup" id="C8V3Q7">
        <property type="interactions" value="1004"/>
    </dbReference>
    <dbReference type="STRING" id="227321.C8V3Q7"/>
    <dbReference type="GeneID" id="2869299"/>
    <dbReference type="KEGG" id="ani:ANIA_08285"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN8285"/>
    <dbReference type="eggNOG" id="KOG0659">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_181_1_1"/>
    <dbReference type="InParanoid" id="C8V3Q7"/>
    <dbReference type="OMA" id="GIHHCHR"/>
    <dbReference type="OrthoDB" id="1732493at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070985">
        <property type="term" value="C:transcription factor TFIIK complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008353">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000097">
        <property type="entry name" value="Putative cyclin-dependent kinase 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF0">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 12" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="1"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="245"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="266"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CBF74278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="296" mass="33526" checksum="6299DE5F1C579E04" modified="2009-11-03" version="1">MDAIREVKYLQELSHPNVIALHDVFSSKDQNLNLVLEYLPRGDLEMLIKDSDIHYGAADVKAWMGMLIRGVWFCHENFVLHRDIKPNNLLIASDGEVKLADFGLARSFADPYMNMTHQVITRWYRPPELLYGARQYSGAVDIWSVGMVFAELLLRVPFVAGNSDLDQISKICEAFGTPTEESWPGVSKLPNYIPADNNIPLQGREFFLRQFPTAGPVGADLLMSMCTLDPRRRTTAHQALQHRWWTTEPRPTNKQDLPQKPGGTKKMGDDLTRRGGELDDQFKNAARQLDFGAIKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2025-10-08" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>C8V6D0</accession>
    <name>C8V6D0_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Thiamine biosynthetic bifunctional enzyme, putative (AFU_orthologue AFUA_2G08970)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">ANIA_10472</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="20">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+) = thiamine phosphate + CO2 + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:47848"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:62890"/>
            <dbReference type="EC" id="2.5.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+) = thiamine phosphate + CO2 + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:47844"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:62899"/>
            <dbReference type="EC" id="2.5.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>4-methyl-5-(2-phosphooxyethyl)-thiazole + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + H(+) = thiamine phosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22328"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:58296"/>
            <dbReference type="EC" id="2.5.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-(2-hydroxyethyl)-4-methylthiazole + ATP = 4-methyl-5-(2-phosphooxyethyl)-thiazole + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24212"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17957"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58296"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.50"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; thiamine diphosphate biosynthesis; 4-methyl-5-(2-phosphoethyl)-thiazole from 5-(2-hydroxyethyl)-4-methylthiazole: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; thiamine diphosphate biosynthesis; thiamine phosphate from 4-amino-2-methyl-5-diphosphomethylpyrimidine and 4-methyl-5-(2-phosphoethyl)-thiazole: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="16">In the C-terminal section; belongs to the Thz kinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="17">In the N-terminal section; belongs to the thiamine-phosphate synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF75182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_661482.2">
        <property type="nucleotide sequence ID" value="XM_656390.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V6D0"/>
    <dbReference type="FunCoup" id="C8V6D0">
        <property type="interactions" value="114"/>
    </dbReference>
    <dbReference type="STRING" id="227321.C8V6D0"/>
    <dbReference type="GeneID" id="2873301"/>
    <dbReference type="KEGG" id="ani:ANIA_10472"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN10472"/>
    <dbReference type="eggNOG" id="ENOG502QS2M">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019943_1_1_1"/>
    <dbReference type="InParanoid" id="C8V6D0"/>
    <dbReference type="OMA" id="GQTDMPI"/>
    <dbReference type="OrthoDB" id="4994at2759"/>
    <dbReference type="UniPathway" id="UPA00060">
        <property type="reaction ID" value="UER00139"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004417">
        <property type="term" value="F:hydroxyethylthiazole kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004789">
        <property type="term" value="F:thiamine-phosphate diphosphorylase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01170">
        <property type="entry name" value="THZ_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00564">
        <property type="entry name" value="TMP_TenI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1190.20:FF:000042">
        <property type="entry name" value="Probable thiamine biosynthetic bifunctional enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000104">
        <property type="entry name" value="Thiamine biosynthetic bifunctional enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00228">
        <property type="entry name" value="Thz_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00097">
        <property type="entry name" value="TMP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000417">
        <property type="entry name" value="Hyethyz_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036206">
        <property type="entry name" value="ThiamineP_synth_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022998">
        <property type="entry name" value="ThiamineP_synth_TenI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034291">
        <property type="entry name" value="TMP_synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006830">
        <property type="entry name" value="PRK09355.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00693">
        <property type="entry name" value="thiE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00694">
        <property type="entry name" value="thiM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20857:SF23">
        <property type="entry name" value="THIAMINE BIOSYNTHETIC BIFUNCTIONAL ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20857">
        <property type="entry name" value="THIAMINE-PHOSPHATE PYROPHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02110">
        <property type="entry name" value="HK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02581">
        <property type="entry name" value="TMP-TENI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01099">
        <property type="entry name" value="HYETHTZKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51391">
        <property type="entry name" value="Thiamin phosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiamine phosphate synthase/TenI" evidence="18">
        <location>
            <begin position="7"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00061146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00061283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CBF75182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="519" mass="54646" checksum="455850C97796C12F" modified="2009-11-03" version="1">MKLDLSVYLVTDSTPPILKGRDLCAVVEEAVKGGVTVVQYRDKKSDTGAQIETARKLHRITQAHGVPLIINDRVDVALAVGAEGVHLGQDDMVISEAKKLLPENAIIGISASSIEEAQAAVAAGADYLGIGTLFATPTKTNTKHIIGTAGTQAILDSIAESGRDVGTVCIGGINLSNVQRVLYQSASPRKSLNGAAIVSAIMAADDPRAAAAELARAIATPPPFVRKADGPLVRNVAGLLEKVPHIVQKMVEIHPLVHNMINFVVANFVANVTLAIGASPIMSPYGDEATDLCQFDGALLINMGTLTSQSPSEYLKAIRAYNQRGNPVVYDPVGAGATQIRRGVVKELMAGGYFDLIKGNEGEIRQVAGSTSVQQRGVDSGPSTLDHQGKARLARDLARREKNIVLLTGAVDYLSDGERIVAVENGHELLGQVTGTGCAVGTVAGCFIAANPTDKFLAVLSALLMYEIAAENAAARDSVRGPGSFATTFIDELYAIRQASLQGDHSWYAGRARVQEISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>C8V6U1</accession>
    <name>C8V6U1_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_03801</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF75354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467448.1">
        <property type="nucleotide sequence ID" value="XM_050611416.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V6U1"/>
    <dbReference type="GeneID" id="2873220"/>
    <dbReference type="KEGG" id="ani:ANIA_03801"/>
    <dbReference type="eggNOG" id="ENOG502S31A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_498766_0_0_1"/>
    <dbReference type="InParanoid" id="C8V6U1"/>
    <dbReference type="OMA" id="VESCHAN"/>
    <dbReference type="OrthoDB" id="4494726at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="518"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF75354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="568" mass="66090" checksum="5A9F67AE8FD808FF" modified="2009-11-03" version="1">MDTEYNYLNDQTVINDLINLSISSESDSLNENEAEIYHENDDRILHERNQAEVEVKECTHINLLDMNHQEVTDAMFNTIFQKRRDIISQRERPETRTTYSLYRSVCKSFQNSVACLASQTSCKPVLRKHSEPLLTSPFFVSRGIHSHPPPPPNKPPQLILDEILDLIRKMQSPDLTPSLFLRSPALKQFCQKYNGQTLSQIHNSFVNQDRFAAIIAKEKALLYRKGRGLAGVRCELDRHPEYREYVRRIYTDHDIVMIICGFNKQIQLLGSLDSFEVDMSYKRVKGDFNEVIFATFLPQHGKIITLLRVFMDHESAFSYKLLFTRVFQLIADIQGYMCAKQMSGLGHYLQELDPLQRPWTWQLMNILILCRTGDLSDYHSSARCRMESLLTCSTREEYFHLIELLEAHETPKIAEWARHKRHSVIAAGATLSSRILDQRDIDQYLARNQYGTSHLSRITSTRKRKRLAQDNELVLSSVEDNRRVLQDSFLHADLVPVVEVQDLDHGEAVTIQVFFRRSATANLQVQNLELQRQQLELEAQQVRIRKEKAEAEKLELENMLRRRELGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C8V897</accession>
    <name>C8V897_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta hydrolase, putative (AFU_orthologue AFUA_2G02920)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_04531</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF77314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_050611703.1"/>
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    <dbReference type="AlphaFoldDB" id="C8V897"/>
    <dbReference type="STRING" id="227321.C8V897"/>
    <dbReference type="ESTHER" id="emeni-q5b4j9">
        <property type="family name" value="6_AlphaBeta_hydrolase"/>
    </dbReference>
    <dbReference type="GeneID" id="2872334"/>
    <dbReference type="KEGG" id="ani:ANIA_04531"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN4531"/>
    <dbReference type="eggNOG" id="ENOG502S2YE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_534212_0_0_1"/>
    <dbReference type="InParanoid" id="C8V897"/>
    <dbReference type="OMA" id="DEATICD"/>
    <dbReference type="OrthoDB" id="408373at2759"/>
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        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0000318"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0046464">
        <property type="term" value="P:acylglycerol catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050266">
        <property type="entry name" value="AB_hydrolase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798:SF5">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE ABHD6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="273"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF77314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="510" mass="55933" checksum="BF7424D3AD044BD6" modified="2009-11-03" version="1">MADRPRVILEKSRTVRRRYQRSNKRFQFTASQIARIEREEEREIQAQKLREKEKRRIQLKKKKAEKEAKAREERIRRGIPDPNAPAVPASQPLLFNFIKRTPSVQPESESPEEQTRADPESHIETDTATESENDDLSFEDEEFDNILIALDGADHPTPVEKADGSGAKNNGNDEDEFSDCSAFYDEDLFKATEIVDQVSVATVLSTDSFEDDTAILLEKFVPDFDPGSSFDQELILTDIQPSPNKMPFVSINNHQLHYADSHPNGAPANGLTFFFIHGLGSSQNYYFPLLPHLTPQHRCITADTYGSGRSTYTGQSVSIASIADDVIGVLDALNIPQAVVVGHSMGGLVVTLLGSEHADRVKGIVAIGPTHPSETLTSVMRKRSATAAEGGMESLANSIPYQATGSAASPLASSFIRELVLGQNPKGYAALCQAIANAPTIDYSAINIPFLLIAGDEDKSASLEGCQYIFDRVSSANKKMEVLPQVGHWHCIEAPDTVGRAIAAFVKTSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>C8VA51</accession>
    <name>C8VA51_EMENI</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ANIA_11628</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF78215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467816.1">
        <property type="nucleotide sequence ID" value="XM_050611834.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VA51"/>
    <dbReference type="GeneID" id="74897186"/>
    <dbReference type="KEGG" id="ani:ANIA_11628"/>
    <dbReference type="HOGENOM" id="CLU_3106322_0_0_1"/>
    <dbReference type="InParanoid" id="C8VA51"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF78215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="51" mass="5639" checksum="8D7F446F94F91182" modified="2009-11-03" version="1">MVIITLEIVCGTPLHGPVSPGQLQQAVNKTDSWFRLYSISGPFVCVQSYKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2025-10-08" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>C8VD02</accession>
    <name>C8VD02_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ANIA_10908</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF78842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_680485.2">
        <property type="nucleotide sequence ID" value="XM_675393.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VD02"/>
    <dbReference type="STRING" id="227321.C8VD02"/>
    <dbReference type="ESTHER" id="emeni-q5aww4">
        <property type="family name" value="Fungal_carboxylesterase_lipase"/>
    </dbReference>
    <dbReference type="GeneID" id="2870023"/>
    <dbReference type="KEGG" id="ani:ANIA_10908"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN10908"/>
    <dbReference type="eggNOG" id="KOG4389">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006586_15_1_1"/>
    <dbReference type="InParanoid" id="C8VD02"/>
    <dbReference type="OMA" id="IMNYRVN"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050654">
        <property type="entry name" value="AChE-related_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918">
        <property type="entry name" value="ACETYLCHOLINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918:SF4">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005125861" description="Carboxylic ester hydrolase" evidence="3">
        <location>
            <begin position="17"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="28"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBF78842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="497" mass="54046" checksum="16938CC0FFDDB522" modified="2009-11-03" version="1">MLFETFLSLLPVAALATAVSTHPQTPSDLIVATSSGIVHGIYNDTAHKVRAFLGIPYAEPATGDLRFAPPQPRAPSQHPINASSFGAPCPQVYNYDNESIWNVLPYRIRNVEDMSEECLFVNIWTPAEHQTKKSGAGRKGKAVMLFIHGGGFGEGAGSVGFYDGVDLASSEDVVVVTFNYRLNVFGYPNAPGLDPAEQNLGLLDQRLAVQWVHQNIANFGGDPDRILLFGQSAGGASVDAYAYAYPEDPLVSGFVLQSGTVSLFNNADTAHANWNRLSTAVGCSAGDGSLACMRSVSFSRILEVLGNGSYTFTPVADNRTVFSDYIARAKAGGLARLVRIRTPLTRCQPTLAGINAREFSAGFPLSQSSINETAVTEDLFGSFSCPAYQAVKTRLRQHIPTWRYVYHGNFTNLSPKPWLGAYHSGAWVAFAQNRHTGLEDYGWPLFTFNETTLVNLAVDNRPGAVLGSAEDWDRHCRGDVYIGYTIPDSLQLHVYNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>C8VEQ4</accession>
    <name>C8VEQ4_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">L-ornithine N(5)-oxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ANIA_08537</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF80752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468115.1">
        <property type="nucleotide sequence ID" value="XM_050612167.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VEQ4"/>
    <dbReference type="GeneID" id="2868799"/>
    <dbReference type="KEGG" id="ani:ANIA_08537"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN8537"/>
    <dbReference type="eggNOG" id="KOG1399">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006937_7_0_1"/>
    <dbReference type="InParanoid" id="C8VEQ4"/>
    <dbReference type="OMA" id="GCQSWYI"/>
    <dbReference type="OrthoDB" id="74360at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051209">
        <property type="entry name" value="FAD-bind_Monooxygenase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877:SF10">
        <property type="entry name" value="L-ORNITHINE N(5)-OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBF80752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="568" mass="63950" checksum="58AF0C972ECEFB24" modified="2009-11-03" version="1">MPPEDAQFLPTYSQIACVGAGISGIALGATLKRWYQMDDIRYFERHSDCGGTWHISSYPGMSVESIEFSANSIYKGCACDVPSALYSYSFAQNPSWTKLMPSYKEIKAYQQEVADNYGLHEKMTFRTEVKECWWREDASRWLMKLRNVETDEISYHECQILFGATGVLVEPRACDIPGASTFKGSLFHTARWNHDVSLDGKKVVVIGNGCTAAQVVPAIMDRSGSVTQIIRSKHWVVETANVQYTPTMLWAFRNIPGLQALHRFAIYQGAEADWQLFPMTKSAAKYRQTRRKEIEAYMRRAAPAKYHDLLIPDFEVGCKRRIFDCGYLDSLHNDKYLLTDAKILEITPEGIQTSNGLIEADVIVLATGFNTNTFLPGMQVHGRDGITVDEHWSRQGGPGAYNTCAMNGFPNFFVLLGPNTVTGHTSAVMAAENSVNYALRVLKPVLDGAASAVEVKADAEHAYVESVQTALRNTVWNAGCHSWYVNEKGWNAMAYPWTQPHFWYRSLFPVWKDWNIKWAQKPATQAWRRLLLAVLLVVSLGVFNRAATSRNVSWWTGIVTGLRKRVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>C8VFG9</accession>
    <name>C8VFG9_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tyrosine/serine protein phosphatase, putative (AFU_orthologue AFUA_6G06650)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_05767</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF81243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468190.1">
        <property type="nucleotide sequence ID" value="XM_050612248.1"/>
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    <dbReference type="AlphaFoldDB" id="C8VFG9"/>
    <dbReference type="STRING" id="227321.C8VFG9"/>
    <dbReference type="GeneID" id="2872058"/>
    <dbReference type="KEGG" id="ani:ANIA_05767"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN5767"/>
    <dbReference type="eggNOG" id="ENOG502S8V4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057546_2_0_1"/>
    <dbReference type="InParanoid" id="C8VFG9"/>
    <dbReference type="OMA" id="PWETIRI"/>
    <dbReference type="OrthoDB" id="9988524at2759"/>
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        <property type="component" value="Chromosome V"/>
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    <dbReference type="GO" id="GO:0016791">
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        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
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    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
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        <property type="entry name" value="Tyr/Ser_Pase_IphP-type"/>
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        <property type="entry name" value="Y_phosphatase3"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="1">
        <location>
            <begin position="131"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF81243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="267" mass="30070" checksum="8E7B325E41F038A3" modified="2009-11-03" version="1">MCSLHYLLPIFILKPYRTEHQMAIKKHKRRHNVSTGSSDFQPQDEDGYIHLPSLDDTETGARRHLISLTGKGFERQLLWRLDWWNFTKVLAYVAAGYKQDAVRIVGEHVMKPAGLTGLAIDTLEASKGEIKQIFDILSSVDTDIAADLSTSASSAGVLIHCTQGKDRTGLIVLLSLLLTSVVDADVIASEYVLSEKELENESSEEKEERMKEIRAIGLDEEYARCPKDFTQRVATFIEEKYGGVREYLVSVGVDEEILESLRRRLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>C8VHJ4</accession>
    <name>C8VHJ4_EMENI</name>
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        <recommendedName>
            <fullName evidence="7">IEC3 subunit of the Ino80 complex, chromatin re-modelling-domain-containing protein</fullName>
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    </protein>
    <gene>
        <name evidence="5" type="ORF">ANIA_10408</name>
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    <organism evidence="5 6">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
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            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF82733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_655938.2"/>
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    <dbReference type="AlphaFoldDB" id="C8VHJ4"/>
    <dbReference type="STRING" id="227321.C8VHJ4"/>
    <dbReference type="GeneID" id="2874556"/>
    <dbReference type="KEGG" id="ani:ANIA_10408"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN10408"/>
    <dbReference type="eggNOG" id="ENOG502SG34">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_038623_0_0_1"/>
    <dbReference type="InParanoid" id="C8VHJ4"/>
    <dbReference type="OMA" id="PVSVYNW"/>
    <dbReference type="OrthoDB" id="1650at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055449">
        <property type="entry name" value="Iec3-like_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032742">
        <property type="entry name" value="Iec3_N"/>
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    <dbReference type="Pfam" id="PF24244">
        <property type="entry name" value="Iec3-like_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14612">
        <property type="entry name" value="Ino80_Iec3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="INO80 complex subunit 3 N-terminal" evidence="3">
        <location>
            <begin position="36"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="INO80 complex subunit 3-like middle region" evidence="4">
        <location>
            <begin position="166"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="175"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="264"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="59"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBF82733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="359" mass="40123" checksum="205A6AB67CAD1B45" modified="2009-11-03" version="1">MVRLFYSTRMSQERDETRSVAGSVPDADAPTKQSHRSFKRKFAKLKIQFELKMKESESLIREQLRIEDLSKRIQEQNDQLLEVLLEFNDALHIPPKLRYDLHVPGDEVILPPPDGELSAAYNDHALATSVLRNAKDDLAAGNITLESYQQLEGGLKRGRAFAPLLRYTDLLKVPHSAPTTESQDPVNPTDDSSLNQNLGFLTPEHETEYCLATDARLGDMAAAVQLSRVPEKPSLLEREREYALRSPVSVHHWLRKNHPNIFLQDNENASEKSASRPSNLRASKRSAPLSRKDEDTHDEDSVMADSGPATGGSKAKRKRDEEATPRSKAVTGRSNRKKKEESTSNNAKRPAKRTSGGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>C8VHV8</accession>
    <name>C8VHV8_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ANIA_11389</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF82924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468403.1">
        <property type="nucleotide sequence ID" value="XM_050612486.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VHV8"/>
    <dbReference type="GeneID" id="74896983"/>
    <dbReference type="KEGG" id="ani:ANIA_11389"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN11389"/>
    <dbReference type="HOGENOM" id="CLU_2413250_0_0_1"/>
    <dbReference type="InParanoid" id="C8VHV8"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF82924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="92" mass="10134" checksum="096E7527CA7F0F97" modified="2009-11-03" version="1">MAGDGSQVGATRSELRKNKVSIISIPLRSLKDIGEKKREFTSGYLGCGTMARVSRATPAGIARQFRKEMSLEEGVDVVLEFTQWATQFDLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>C8VHX7</accession>
    <name>C8VHX7_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mitochondrial division protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ANIA_10391</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in mitochondrial fission. Acts as an adapter protein required to form mitochondrial fission complexes. Formation of these complexes is required to promote constriction and fission of the mitochondrial compartment at a late step in mitochondrial division.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the WD repeat MDV1/CAF4 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF82958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468408.1">
        <property type="nucleotide sequence ID" value="XM_050612493.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VHX7"/>
    <dbReference type="STRING" id="227321.C8VHX7"/>
    <dbReference type="GeneID" id="74896379"/>
    <dbReference type="KEGG" id="ani:ANIA_10391"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN10391"/>
    <dbReference type="eggNOG" id="KOG0295">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_472531_0_0_1"/>
    <dbReference type="InParanoid" id="C8VHX7"/>
    <dbReference type="OMA" id="KQTHERT"/>
    <dbReference type="OrthoDB" id="538223at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990234">
        <property type="term" value="C:transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:003633">
        <property type="entry name" value="WD repeat-containing protein 38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847:SF637">
        <property type="entry name" value="WD REPEAT DOMAIN 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="292"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="334"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="375"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="417"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="459"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="501"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00043913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBF82958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="577" mass="64679" checksum="2468228F9C15E0C1" modified="2009-11-03" version="1">MANRSYYDQKMSTLRDLGTSWESCRRVLSTVTLAQRPLRLAELCVLSGLPQETQAKDIVALCDSFLTINEKDDSVDVDLPTKDYLINEARDEIYPSGVTGAHLSLFSRSLEAMSSTLRRNIYSLHHPGVSVDEDMLLIPEPDPLATIRYSCVHWISHFCDAYESDACHKHQIDPDNAKSVDNFLRSTTLYWLEVLSLIQETASALRSMWRLVLLLRRKSSDSDLLDLVRDSYRFFLQNISAIKCAPLQVYASALVFSPADSLIRKLFGKEEPNWIETKPDVANHWSPCLQALEGHEAAVLSVSYSHDSRLLASASDDRTVKIWDTETGSLQHTLEGHSDLVRSVIFSHDSRLLASASDSTVKIWDTGTGSLQHTLEGHRDWVRSVIFSHDSQLLASASDDSTVKIWDTGTGSLQHTLEGHRDWVRSVIFSHDSQLLASASDDSTVKIWDTGTGSLQHTLEGHRDWVRSVIFSHDSRLLASASDDRTVRIWDTEKGSHKHTLEGHSSLVTSVSFSHDSRLLASASNDQTVRIWDIEARSLQHTFDLDATIEAMRFDKATSLWIQVTVKASIRSAMGMA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2019-02-13" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>C8VI80</accession>
    <accession>Q5B8A4</accession>
    <name>PKFC_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Short-chain dehydrogenase/reductase pkfC</fullName>
            <ecNumber evidence="8">1.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Aspernidine A biosynthesis cluster protein pkfC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">pkfC</name>
        <name type="ORF">ANIA_03226</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2012" name="J. Am. Chem. Soc." volume="134" first="8212" last="8221">
            <title>Illuminating the diversity of aromatic polyketide synthases in Aspergillus nidulans.</title>
            <authorList>
                <person name="Ahuja M."/>
                <person name="Chiang Y.M."/>
                <person name="Chang S.L."/>
                <person name="Praseuth M.B."/>
                <person name="Entwistle R."/>
                <person name="Sanchez J.F."/>
                <person name="Lo H.C."/>
                <person name="Yeh H.H."/>
                <person name="Oakley B.R."/>
                <person name="Wang C.C."/>
            </authorList>
            <dbReference type="PubMed" id="22510154"/>
            <dbReference type="DOI" id="10.1021/ja3016395"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2013" name="Org. Lett." volume="15" first="2862" last="2865">
            <title>Molecular genetic characterization of the biosynthesis cluster of a prenylated isoindolinone alkaloid aspernidine A in Aspergillus nidulans.</title>
            <authorList>
                <person name="Yaegashi J."/>
                <person name="Praseuth M.B."/>
                <person name="Tyan S.W."/>
                <person name="Sanchez J.F."/>
                <person name="Entwistle R."/>
                <person name="Chiang Y.M."/>
                <person name="Oakley B.R."/>
                <person name="Wang C.C."/>
            </authorList>
            <dbReference type="PubMed" id="23706169"/>
            <dbReference type="DOI" id="10.1021/ol401187b"/>
        </citation>
        <scope>IDENTIFICATION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>FUNCTION</scope>
        <scope>PATHWAY</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2015" name="Genetics" volume="199" first="1127" last="1142">
            <title>Beyond asexual development: modifications in the gene expression profile caused by the absence of the Aspergillus nidulans transcription factor FlbB.</title>
            <authorList>
                <person name="Oiartzabal-Arano E."/>
                <person name="Garzia A."/>
                <person name="Gorostidi A."/>
                <person name="Ugalde U."/>
                <person name="Espeso E.A."/>
                <person name="Etxebeste O."/>
            </authorList>
            <dbReference type="PubMed" id="25701285"/>
            <dbReference type="DOI" id="10.1534/genetics.115.174342"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="4 5 8">Short-chain dehydrogenase/reductase; part of the gene cluster that mediates the biosynthesis of aspernidine A, a prenylated isoindolinone (PubMed:23706169). The starting point of the biosynthesis of aspernidin A is the production of orsellinaldehyde by the non-reducing polyketide synthase pkfA (PubMed:22510154). Hydroxylation, methylation of one of the phenol groups, and prenylation, presumably catalyzed by the prenyltransferase pkfE, would be needed to yield aspernidine D (Probable). Subsequently, the cytochrome P450 monooxygenase pkfB is responsible for hydroxylation of aspernidine D to yield aspernidine E (PubMed:23706169). The dehydrogenase pkfF may be responsible for further oxidation of aspernidine E to form a dialdehyde intermediate which is further transformed in a series of steps, some of which are enzyme-mediated, to generate aspernidine A (Probable). The possibility that additional enzymes outside of the cluster are involved in aspernidine A biosynthesis cannot be excluded.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="5">Abolishes the production of Aspernidine A.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="sequence caution" evidence="7">
        <conflict type="erroneous gene model prediction">
            <sequence resource="EMBL-CDS" id="EAA63127" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EC" id="1.1.1.-" evidence="8"/>
    <dbReference type="EMBL" id="AACD01000054">
        <property type="protein sequence ID" value="EAA63127.1"/>
        <property type="status" value="ALT_SEQ"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF83147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VI80"/>
    <dbReference type="SMR" id="C8VI80"/>
    <dbReference type="STRING" id="227321.C8VI80"/>
    <dbReference type="EnsemblFungi" id="CBF83147">
        <property type="protein sequence ID" value="CBF83147"/>
        <property type="gene ID" value="ANIA_03226"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AN3226"/>
    <dbReference type="eggNOG" id="KOG1208">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_44_6_1"/>
    <dbReference type="InParanoid" id="C8VI80"/>
    <dbReference type="OMA" id="FNPGNLQ"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097308">
        <property type="term" value="P:cellular response to farnesol"/>
        <property type="evidence" value="ECO:0000270"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:001499">
        <property type="entry name" value="Short-chain dehydrogenase/reductase pkfC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF236">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-0521">NADP</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000446361" description="Short-chain dehydrogenase/reductase pkfC">
        <location>
            <begin position="1"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="193"/>
        </location>
    </feature>
    <feature type="active site" description="Lowers pKa of active site Tyr" evidence="2">
        <location>
            <position position="197"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="L0E2Z4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="O93868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="22510154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="23706169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="6">
        <source>
            <dbReference type="PubMed" id="23706169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="7"/>
    <evidence type="ECO:0000305" key="8">
        <source>
            <dbReference type="PubMed" id="23706169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBF83147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="312" mass="34218" checksum="D8BD74C513722FB3" modified="2009-11-03" version="1">MVFGSRPPALTEANIGDQSGKVFIVTGATSGYGLLLSTYLYQNNGTVYLAARNAKKTAEVIADLKQRFPASRGRLDSISLNLSDLSTIKKSAEEFLAKETRLHVLWNNAGVMFPPAGSTTSQGYELQLGTNNVGPHLFTKLLYPTLAATAKEAPKNTVRVVWVSSDAASWAPKPAIDFNNLDYRRNESDRSKYGRSKAGTVMQAVELARRARKDGSGIVSIALDPGIANTGLQRDMGRLMSTMVKLIANKPEIGAYTQLFAGLSPEITAEVAEKEWVVPPGKIGCPRRDLFTDTETSRKWWEWNEEQVKAYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>C8VIG5</accession>
    <name>C8VIG5_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Glutamate--cysteine ligase</fullName>
            <ecNumber evidence="3 11">6.3.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Gamma-ECS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9 11">Gamma-glutamylcysteine synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">ANIA_03150</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-cysteine + L-glutamate + ATP = gamma-L-glutamyl-L-cysteine + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13285"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the glutamate--cysteine ligase type 3 family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.2" evidence="3 11"/>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF83306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468447.1">
        <property type="nucleotide sequence ID" value="XM_050612536.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VIG5"/>
    <dbReference type="FunCoup" id="C8VIG5">
        <property type="interactions" value="379"/>
    </dbReference>
    <dbReference type="STRING" id="227321.C8VIG5"/>
    <dbReference type="GeneID" id="2874121"/>
    <dbReference type="KEGG" id="ani:ANIA_03150"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN3150"/>
    <dbReference type="eggNOG" id="KOG3754">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010467_1_0_1"/>
    <dbReference type="InParanoid" id="C8VIG5"/>
    <dbReference type="OMA" id="IAHMFIR"/>
    <dbReference type="OrthoDB" id="7939818at2759"/>
    <dbReference type="UniPathway" id="UPA00142">
        <property type="reaction ID" value="UER00209"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017109">
        <property type="term" value="C:glutamate-cysteine ligase complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004357">
        <property type="term" value="F:glutamate-cysteine ligase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006750">
        <property type="term" value="P:glutathione biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.960:FF:000002">
        <property type="entry name" value="Glutamate-cysteine ligase Gcs1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.590.50:FF:000001">
        <property type="entry name" value="Glutamate-cysteine ligase Gcs1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.590.50:FF:000004">
        <property type="entry name" value="Glutamate-cysteine ligase Gcs1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.960">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.590.50">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004308">
        <property type="entry name" value="GCS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11164">
        <property type="entry name" value="GLUTAMATE CYSTEINE LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11164:SF0">
        <property type="entry name" value="GLUTAMATE--CYSTEINE LIGASE CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03074">
        <property type="entry name" value="GCS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 11" id="KW-0317">Glutathione biosynthesis</keyword>
    <keyword evidence="5 11 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="492"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CBF83306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="642" mass="73100" checksum="D956FDF8F2CF54A1" modified="2009-11-03" version="1">MGLLALGTALEWPEAKKRADQVRKWGIEQLLANWHRAKGKERDALLWGDEVEYLVVALDDAAKKARLSLAQADILKSLARDEELWKEGSCTYSQNKEHEGEEPPHFHPEFGRFMLEATPGVPWGIGFKDLLKVESNMRWRREVAKAHMAPNESPITLTTFPRLGTKDDYIQPYYPPSGPALRSQFVPDEIANPHIRFPTLAANIRARRGRKVELNVPVFKDKNTPEPFKDPTVNYDLHNWPEDDDVRNGAAKDGHVYMDAMAFGMGSCCLQITFQAKNVPEGRKLYDQLSPLGPILLALTAATPIYKGFLVDTDVRWNQISKAVDDRTREELGEVDPRLRKEYLDPDLIVDEDIKKRLMDDGMDELLATHFAHLFIRDPIVIFSEDLEELDLNKADHFENLQSTNWQHMRFKPPPPEKDDIGWRVEFRSMEIQMTDFENAAFSIFIVLVTRAILSFDLNFYIPIQRTAENMETAHARNAVLDRKFYFRKDPFSPSVRRHHNSSGDSNTSSANNTPPPSPPLGPVEYEFELMTISDIINGSADGSFPGLIPLVESYLNSVNVDVETRCSLARYLDLIRKRANGTLWTGAKWIREFVAQHPAYKQDSVVSEEICYDLVKAVEEMSVKEGADGSVGWEMLKGRTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>C8VII2</accession>
    <name>C8VII2_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ubiquitin conjugating enzyme, putative (AFU_orthologue AFUA_3G13060)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ANIA_03136</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF83338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468454.1">
        <property type="nucleotide sequence ID" value="XM_050612543.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VII2"/>
    <dbReference type="STRING" id="227321.C8VII2"/>
    <dbReference type="GeneID" id="2874255"/>
    <dbReference type="KEGG" id="ani:ANIA_03136"/>
    <dbReference type="eggNOG" id="KOG0895">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005619_1_0_1"/>
    <dbReference type="InParanoid" id="C8VII2"/>
    <dbReference type="OMA" id="EMWIEYE"/>
    <dbReference type="OrthoDB" id="47801at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd23837">
        <property type="entry name" value="UBCc_UBE2O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000094">
        <property type="entry name" value="Probable ubiquitin-conjugating enzyme E2 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057735">
        <property type="entry name" value="UBE2O-like_tSH3-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46116">
        <property type="entry name" value="(E3-INDEPENDENT) E2 UBIQUITIN-CONJUGATING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46116:SF15">
        <property type="entry name" value="(E3-INDEPENDENT) E2 UBIQUITIN-CONJUGATING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23046">
        <property type="entry name" value="tSH3-B_UBE2O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="3">
        <location>
            <begin position="785"/>
            <end position="953"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBF83338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="1070" mass="118712" checksum="748B91AD988D675C" modified="2009-11-03" version="1">MMYVAWFSYPTHQQYHVLTLSKLEEPELLGELLTGTYDGVPEEDVDIFITTSTILINHKPPEGYVFVIYIQPSHGSSLIHENDLELVDRVYELGETVKHNLSENDTMSGTIIGVSRRCTLEPIIYQPRDPITGDYLPVRFTEKPYKGYEASSASEEAGPFLLYDVPQSDLRGQEQFSEGDYIIYRQKLGLVQEVEHDVILLLPDSRVVSPLDPYALELPISDPACAISSVDLKSRDVGDGKYVWTTGTDSIYPGQSVFTERLNLSRADRPLGAQRSVVQGYVLATPAERIHVHWLCSNVFADGRSYYVSTEEVLRASTLQQDAIRCNFVRSPNQDSLAGGCDPMFDVGSYVRFHNPAHAQVKYPGLWQVPSHQSFGYDLNIFRIVSAKTQVTVQWQNGSCTTETATSLLPSDAGGDELYPGDMVALKDSVSVINFHTANRRIVSRLARGRFNETLRIQQLGIVHTFDSRERIASVRWYQDTDIELINGGNSLNPSCSLGRLGDTITDVSVYELTTFPALSKNLGDYVVVAPASISQSVMSSIPHDIPKVNEPRRIHSIAADAFLDPSSYLQSIKSALISSEWFKNTTTVQVPSLRRRYSIQNSDAAPLNDFFGKIVAKDTSGNITVRFPGPSGCRDIQVPFERILVVITSAESVTPNVQDHSSPYLNEDTLAGATANGCIVKDDNHGFPNCNELVTSQEGELKIGTIERGLVMTVSETCLESPMPDDGEIAVDGTPTPAPTKSGLPAILSFPVPTLSPPGFTVLEDLPPVDHHFINQNHAGSSTERMKRIRKEFAILESSLPSGIFVRSWESRIDLLRILFIGAESTPYEHAPYVVDMHFPSDFPHSPPSAFFHSWGSGEGSINPNLSEDGNICLSLLGTWPTRDLDERWSPARSTVLQLLVSIMGLILVQDPFYSEFPPFLHLSTHTQTLSDEAGYESLAAKGSRTIESSQYKEKVFLLTRRFIIHALEHPIRGLEDVLVWNYLPGLPSPRPQLLRKAIQEARVMIEHHNRTSESHQDSKASAFCSRLSQGATVLLQKLVSALERLETDLKARVVSKVTASQGSDRFIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>C8VJ25</accession>
    <name>C8VJ25_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">alpha-galactosidase</fullName>
            <ecNumber evidence="2">3.2.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ANIA_02953</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.</text>
            <dbReference type="EC" id="3.2.1.22"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.2.1.22" evidence="2"/>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF83682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_660557.2">
        <property type="nucleotide sequence ID" value="XM_655465.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VJ25"/>
    <dbReference type="STRING" id="227321.C8VJ25"/>
    <dbReference type="GeneID" id="2874022"/>
    <dbReference type="KEGG" id="ani:ANIA_02953"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN2953"/>
    <dbReference type="eggNOG" id="ENOG502RCTR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051214_1_1_1"/>
    <dbReference type="InParanoid" id="C8VJ25"/>
    <dbReference type="OMA" id="EYSECET"/>
    <dbReference type="OrthoDB" id="2108802at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004557">
        <property type="term" value="F:alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004352">
        <property type="entry name" value="GH114_TIM-barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35273">
        <property type="entry name" value="ALPHA-1,4 POLYGALACTOSAMINIDASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G07890)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35273:SF2">
        <property type="entry name" value="ALPHA-GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03537">
        <property type="entry name" value="Glyco_hydro_114"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside-hydrolase family GH114 TIM-barrel" evidence="5">
        <location>
            <begin position="78"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBF83682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="314" mass="35066" checksum="597C6AFEF7DF5151" modified="2009-11-03" version="1">METLKAPSTGWKSWTAKKKALLISSILIFIIALAVGLGVGLGLGLNKGSDNDNESGGNNTTPTTPNNTAIWQPAVGTSWQIVLRYALNDTSYDVDVYDIDLFDNKKAIIDELHSDGRKVICYFSAGTYEDWRDDADKFPEDDIGDNLDEWEGESWVDIRSSKIRDIMLDRLDIAVQKGCDGVDPDNVDGYDNQNGLDLTQDDTVDYMNFLADEAHSRNLSIGLKNAGAVIPRVISRMQWSVNEQCAQYDECDTYAAFVRRGKPVFHIEYPKGDDTNNEVQVTGQKKATACDFDDSNEFSTLIKNMDLDNWLQEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>C8VKK5</accession>
    <name>C8VKK5_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS monosaccharide transporter, putative (AFU_orthologue AFUA_2G05190)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ANIA_02585</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF87149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468934.1">
        <property type="nucleotide sequence ID" value="XM_050613093.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VKK5"/>
    <dbReference type="GeneID" id="2875711"/>
    <dbReference type="KEGG" id="ani:ANIA_02585"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN2585"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_12_1"/>
    <dbReference type="InParanoid" id="C8VKK5"/>
    <dbReference type="OMA" id="EWCEIRA"/>
    <dbReference type="OrthoDB" id="8120565at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000026">
        <property type="entry name" value="MFS quinate transporter QutD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF14">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="163"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="272"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="305"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="336"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="370"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="407"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="436"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="1"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBF87149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="499" mass="54980" checksum="C30C153EF0C658EC" modified="2009-11-03" version="1">MGGKVGGLSFGYDQGVISVTLVMEQFLGRFVEVAEGHPGSGFWKGLMTAMLELGAFVGALNQGWLADKISRRYSIVVAVAIFNVGSVLQTAAVDYAMLTVGRTIGGIGIGMLSMVAPLYISEVSPPECRGALLVLEEFCIVLGIVIAYWITYGTRFMAGEWAWRLPFLLQIVPSFVLLGGVIVLPFSPRWLASKGRNDEALQSLSQLRRLPTTDHRIQQELLDIKIDVRFHQELNAEKHPTLQGSGTTKSLLRELAGWADCFKSGCWRRTQVAVLVMFFQQFVGINALIYYSPTLFKTMGLDYDMQLLMSGIINVTQLVGVCTSLWTMDALGRRPLLLWGAAIMGISHVIIAALVGIYSDNWPAHRTRGWTSVAFLFVYMLAFGATWGSVGWALPAEVFSSFLRAKGVALATCGTWLFNFIIGLITPPLIQDTGYGAYVFFAVFCILAFIWTFFCVPETSGRTLEQMDAVFKDNSISAERARRQAIENELMGEHHGVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C8VM97</accession>
    <name>C8VM97_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HORMA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ANIA_02163</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MAD2 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF86297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_659767.2">
        <property type="nucleotide sequence ID" value="XM_654675.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VM97"/>
    <dbReference type="STRING" id="227321.C8VM97"/>
    <dbReference type="GeneID" id="2875287"/>
    <dbReference type="KEGG" id="ani:ANIA_02163"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN2163"/>
    <dbReference type="eggNOG" id="KOG3186">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050394_1_1_1"/>
    <dbReference type="InParanoid" id="C8VM97"/>
    <dbReference type="OMA" id="KEEQTWI"/>
    <dbReference type="OrthoDB" id="21254at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
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    <dbReference type="GO" id="GO:0016035">
        <property type="term" value="C:zeta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0000318"/>
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    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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    <dbReference type="FunFam" id="3.30.900.10:FF:000005">
        <property type="entry name" value="Mitotic spindle checkpoint protein"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="3.30.900.10">
        <property type="entry name" value="HORMA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003511">
        <property type="entry name" value="HORMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036570">
        <property type="entry name" value="HORMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045091">
        <property type="entry name" value="Mad2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11842">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11842:SF10">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02301">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56019">
        <property type="entry name" value="The spindle assembly checkpoint protein mad2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50815">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HORMA" evidence="3">
        <location>
            <begin position="31"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="227"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBF86297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="283" mass="31194" checksum="9E8BEB50BE85580A" modified="2009-11-03" version="1">MPIASESTTTTTTMTTFSAPVTAPRTPHNQAALAASFTNFLTVSVHQILWLRSVYPRATFLPVRAYNYPVRQSRHPKVCDYINDASIAVGTEILKGTITAVSIILSSARTNQPLERYAFDLSGFPRVPPGEVHTTFEDRMEDSSKSAPHNSQVLDLEAQFRACLARLASACARLTPLPRDDEFSFTVCIEVREDALPPAGTTTEEQTWVVAEPGKVHLRSCSAPYSVSKLKNGGPQQPPPKVSNGRAKTVPVRRVEAGELRLELWVEEARQKFNEPVDSEHPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>C8VMY3</accession>
    <name>C8VMY3_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">Protein phosphatase PP2A regulatory subunit B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ANIA_01545</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Phosphatase 2A affects a variety of biological processes in the cell such as transcription, cell cycle progression and cellular morphogenesis, and provides an initial identification of critical substrates for this phosphatase. The regulatory subunit may direct the catalytic subunit to distinct, albeit overlapping, subsets of substrates.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the phosphatase 2A regulatory subunit B family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF85082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468677.1">
        <property type="nucleotide sequence ID" value="XM_050612799.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VMY3"/>
    <dbReference type="FunCoup" id="C8VMY3">
        <property type="interactions" value="741"/>
    </dbReference>
    <dbReference type="STRING" id="227321.C8VMY3"/>
    <dbReference type="GeneID" id="2874884"/>
    <dbReference type="KEGG" id="ani:ANIA_01545"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN1545"/>
    <dbReference type="eggNOG" id="KOG1354">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021713_3_3_1"/>
    <dbReference type="InParanoid" id="C8VMY3"/>
    <dbReference type="OMA" id="NQIKWCR"/>
    <dbReference type="OrthoDB" id="6274823at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005934">
        <property type="term" value="C:cellular bud tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="C:mitotic spindle pole body"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="AspGD"/>
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        <property type="term" value="C:protein phosphatase type 2A complex"/>
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    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000705">
        <property type="term" value="P:achiasmate meiosis I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0071475">
        <property type="term" value="P:cellular hyperosmotic salinity response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045143">
        <property type="term" value="P:homologous chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016237">
        <property type="term" value="P:microautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0044818">
        <property type="term" value="P:mitotic G2/M transition checkpoint"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001100">
        <property type="term" value="P:negative regulation of exit from mitosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010515">
        <property type="term" value="P:negative regulation of induction of conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031030">
        <property type="term" value="P:negative regulation of septation initiation signaling"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043945">
        <property type="term" value="P:positive regulation of asexual sporulation resulting in formation of a cellular spore"/>
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        <property type="project" value="AspGD"/>
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    <dbReference type="GO" id="GO:2000786">
        <property type="term" value="P:positive regulation of autophagosome assembly"/>
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        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0010971">
        <property type="term" value="P:positive regulation of G2/M transition of mitotic cell cycle"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905477">
        <property type="term" value="P:positive regulation of protein localization to membrane"/>
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        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:1900182">
        <property type="term" value="P:positive regulation of protein localization to nucleus"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061586">
        <property type="term" value="P:positive regulation of transcription by transcription factor localization"/>
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        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0090266">
        <property type="term" value="P:regulation of mitotic cell cycle spindle assembly checkpoint"/>
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        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0031028">
        <property type="term" value="P:septation initiation signaling"/>
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        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000174">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000189">
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    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000009">
        <property type="entry name" value="PP2A_PR55"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018067">
        <property type="entry name" value="PP2A_PR55_CS"/>
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    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11871">
        <property type="entry name" value="PROTEIN PHOSPHATASE PP2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="PP2A_PR55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00600">
        <property type="entry name" value="PP2APR55"/>
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        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PR55_1"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS01025">
        <property type="entry name" value="PR55_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 7" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="403"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="415"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00055525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00067298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU331113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBF85082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="472" mass="53409" checksum="08367C545DF4619D" modified="2009-11-03" version="1">MVDRDPGTPTWKFTQCFGDKGDVEDITEADIISTVEFDHTGNYLATGDKGGRVVLFERNETKKTCEYKFHTEFQSHEPEFDYLKSLEIEEKINKIKWCRRQNASHFLLSTNDKTIKLWKVFDKSLKVVAENNLSTELTPGGVGGGGAPRAPRVSFKDSSALKLPRMTHHDTVVAAVPRRTYANAHAYHINSISVNSDGETFISSDDLRVNLWNLNIQDQSFNIVDIKPANMEELTEVITAAEFHPTSCNWFMYASSKGTIKLADMRQRALCDTHHKLFEQEEDASSRSFFSEIISSISDVRFSHDGRYIVSRDYLTVKIWDVNMERQPVKTIPIHEHLRPRLCDTYENDSIFDKFEVVFSGDAENVMTGSYNNNFMIYPTDPAKETEIVLQADKSAFKAKKVGVPTPMNKGANGKKSNSRTSSPAGPGSRMKKETDADQIDFNKKILHMSWHPFEDSIAIAATNNLFVFSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>C8VNE7</accession>
    <name>C8VNE7_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DMATS type aromatic prenyltransferase, putative (JCVI)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_10289</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the tryptophan dimethylallyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF86654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468868.1">
        <property type="nucleotide sequence ID" value="XM_050613025.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VNE7"/>
    <dbReference type="GeneID" id="74896322"/>
    <dbReference type="KEGG" id="ani:ANIA_10289"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN10289"/>
    <dbReference type="eggNOG" id="ENOG502S2XP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037431_4_0_1"/>
    <dbReference type="InParanoid" id="C8VNE7"/>
    <dbReference type="OMA" id="EYTYLAW"/>
    <dbReference type="OrthoDB" id="5392033at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009821">
        <property type="term" value="P:alkaloid biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd13929">
        <property type="entry name" value="PT-DMATS_CymD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033964">
        <property type="entry name" value="ABBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017795">
        <property type="entry name" value="ABBA_NscD-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03429">
        <property type="entry name" value="arom_pren_DMATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40627">
        <property type="entry name" value="INDOLE PRENYLTRANSFERASE TDIB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40627:SF3">
        <property type="entry name" value="PRENYLTRANSFERASE ASQH2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11991">
        <property type="entry name" value="Trp_DMAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00036">
        <property type="entry name" value="Aromatic_Prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF86654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="449" mass="50861" checksum="FFCED7D167FA47AA" modified="2009-11-03" version="1">MPSFSNGNQLQISSTSLPLQGKLVPKPISTQPFTLLTSYLPFTNEAQRQWWLDSGSLFSRFLQASQYTTGQQYKHLLFFHRYLLPFLGTYPPTWFSIVSRQGLAIEYSLNFQASGNPVIRSAFEPLSYASGKDAADPLNKRPTEDLLAGLVEQGLEGFDMTLFDHVRDTIFISDEETAALENPDAYGIKTHTALGFDMKGDNTVVKCYMHPRWKSLATGVPVAKLIRDSLERIKDQFDCEQALELVDEYMEDSGSWDLRTFIAWDCVPLAQTRLKIYGIINEVSLGKVEELWTMGGRLNDETTLEGLSLLRRLWHLLEVNKDDRLFSKGDEEKLEYGPTVDGFLPLFWNYEIWAGSNKVAPKVYIPVYGENDLKVALALSRFFRSLGPAWQEKADGLAMCSYAPKQPRSRYQSDNKTPGLDFVCVLPGEGSLRECLLPFDQFISIPRAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>C8VRM6</accession>
    <name>C8VRM6_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Golgi matrix protein, putative (AFU_orthologue AFUA_1G08830)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ANIA_10186</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF87581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468984.1">
        <property type="nucleotide sequence ID" value="XM_050613146.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VRM6"/>
    <dbReference type="STRING" id="227321.C8VRM6"/>
    <dbReference type="GeneID" id="2877170"/>
    <dbReference type="KEGG" id="ani:ANIA_10186"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN10186"/>
    <dbReference type="eggNOG" id="ENOG502RYXN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020680_1_1_1"/>
    <dbReference type="InParanoid" id="C8VRM6"/>
    <dbReference type="OMA" id="QAMHNWE"/>
    <dbReference type="OrthoDB" id="425925at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
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        <property type="entry name" value="MYOSIN HEAVY CHAIN - RELATED"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR18921:SF2">
        <property type="entry name" value="THYROID RECEPTOR-INTERACTING PROTEIN 11"/>
        <property type="match status" value="1"/>
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        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Coils"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50913"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CBF87581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="510" mass="57802" checksum="DFEAE8DF75D1E549" modified="2009-11-03" version="1">MPEGGKSKNKNKARQPDAADVNTSDDNRSGLSGANDVQPDTTDSHTPEETTNGKEIDANSTDHGHADIESDDSRAKSPILEALRSKDRFDALVRDRDSLRAEVTDMRKSLEEIQSKHRTDMQALQSKLDDAESKKEHAESQYRGLLERVNTIKAQLGERLKEDAEEISQARSRIEELEEQNSSTKEEYEAKISELSEENQRMAKELSELRERTNLSQQNWLREKDDLLEQESYLQSEFEQAKEAMHNWEVLAMEERSIRENLGEKVIDLEEQLTTLKDAYERTSAERDSQAAAVDGLQRALQEIQAARKQELRELVESSDAQLEGLKQSLNEAKSKESEAMKSLQDLQQELERVRPFEKEVREKNLLIGKLRHEAVTLNDHLTKALRFLKKGKPEDNVDRHIVTNHLLHFLALDRSDPKKFQILQLIAALLGWSDEQREQAGLARPGASGASARLRVPGSPMHRTPSTPSLATEFRDNGAASKESLAELWSNFLEQESQASSHDNSPLTK</sequence>
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<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>C8VRP9</accession>
    <name>C8VRP9_EMENI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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    <gene>
        <name evidence="2" type="ORF">ANIA_00693</name>
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    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
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            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF88972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_653205.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VRP9"/>
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    <dbReference type="KEGG" id="ani:ANIA_00693"/>
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    <dbReference type="eggNOG" id="ENOG502SVIN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_136305_1_0_1"/>
    <dbReference type="InParanoid" id="C8VRP9"/>
    <dbReference type="OMA" id="THRITQP"/>
    <dbReference type="OrthoDB" id="3913483at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF88972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="136" mass="14283" checksum="086FF67B95648A7E" modified="2009-11-03" version="1">MSDSTFHTTIQDIRKPESHASHAAKGNTPKDSNVSAMKSIIDQNTDKQADIEKTKANLPLPDQPPVASDWNSADQRAVNVGSGGIEGPISGENNSALRGPATASSSAREVGEETHRNTQPTSNVGRGDLPADAQAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2025-10-08" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>C8VSH7</accession>
    <name>C8VSH7_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">3-oxoacyl-(Acyl-carrier-protein) reductase (AFU_orthologue AFUA_1G10100)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ANIA_10169</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF87832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <location>
            <begin position="10"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
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    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU000363"/>
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        <source>
            <dbReference type="SMART" id="SM00822"/>
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        <source>
            <dbReference type="EMBL" id="CBF87832.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
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    <sequence length="296" mass="31673" checksum="7E8EE9AD32D2AD7E" modified="2009-11-03" version="1">MSRPLEGKFGIVTGGSRGIGEAIAKNLASKGCSLLLNFTSESSRSRTEELCKQLSTAHSIRCVSVQADLSKPEEAVSRILTAASEQFPNTTIDILINNAGVSADRTLNDTEKGPIDADYFNWHYNINVLAPLLLTQAIAPHLPNNRTGRIVNISSVSSSLGFIGQSAYGGTKAALEAMTRTWARELADRATVNAVNPGPVSGDMYFNTGEGFWKQIQGFQDGTPLSKLVDDVDRDPVLKEIGLSDEQKRLVREKMGGRRPAFTEEVAGVVGMLCTADGGWCTGSVVCANGGMKFTV</sequence>
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<entry dataset="TrEMBL" created="2009-11-03" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>C8VTN5</accession>
    <name>C8VTN5_EMENI</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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        <name evidence="1" type="ORF">ANIA_11293</name>
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    <organism evidence="1 2">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF88211.1"/>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VTN5"/>
    <dbReference type="HOGENOM" id="CLU_3419423_0_0_1"/>
    <dbReference type="InParanoid" id="C8VTN5"/>
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        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF88211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="25" mass="2921" checksum="B203DA3355F04214" modified="2009-11-03" version="1">MQARCVSGLDRTVRGLKLYLFQFMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>C8VUC6</accession>
    <name>C8VUC6_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ATP synthase subunit delta, mitochondrial</fullName>
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        <alternativeName>
            <fullName evidence="13">F-ATPase delta subunit</fullName>
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    <gene>
        <name evidence="16" type="ORF">ANIA_10032</name>
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    <organism evidence="16 17">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
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                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="17">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase epsilon chain family.</text>
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    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF89828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050469275.1">
        <property type="nucleotide sequence ID" value="XM_050611001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VUC6"/>
    <dbReference type="FunCoup" id="C8VUC6">
        <property type="interactions" value="717"/>
    </dbReference>
    <dbReference type="STRING" id="227321.C8VUC6"/>
    <dbReference type="GeneID" id="2876055"/>
    <dbReference type="KEGG" id="ani:ANIA_10032"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN10032"/>
    <dbReference type="eggNOG" id="KOG1758">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084338_0_0_1"/>
    <dbReference type="InParanoid" id="C8VUC6"/>
    <dbReference type="OMA" id="PHQTIYR"/>
    <dbReference type="OrthoDB" id="270171at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd12152">
        <property type="entry name" value="F1-ATPase_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.15.10:FF:000003">
        <property type="entry name" value="ATP synthase subunit delta, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.15.10">
        <property type="entry name" value="F0F1 ATP synthase delta/epsilon subunit, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00530">
        <property type="entry name" value="ATP_synth_epsil_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001469">
        <property type="entry name" value="ATP_synth_F1_dsu/esu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020546">
        <property type="entry name" value="ATP_synth_F1_dsu/esu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048938">
        <property type="entry name" value="ATPD_C_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036771">
        <property type="entry name" value="ATPsynth_dsu/esu_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01216">
        <property type="entry name" value="ATP_synt_epsi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13822">
        <property type="entry name" value="ATP SYNTHASE DELTA/EPSILON CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13822:SF7">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT DELTA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02823">
        <property type="entry name" value="ATP-synt_DE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21334">
        <property type="entry name" value="ATPD_C_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51344">
        <property type="entry name" value="Epsilon subunit of F1F0-ATP synthase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="11" id="KW-0139">CF(1)</keyword>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATP synthase F1 complex delta/epsilon subunit N-terminal" evidence="14">
        <location>
            <begin position="37"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="F1F0-ATP synthase subunit delta C-terminal" evidence="15">
        <location>
            <begin position="123"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF21334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CBF89828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="166" mass="17952" checksum="AC64EEA13832C8E0" modified="2009-11-03" version="1">MMTPLRFARSALRARPAAFRVPLQRRGYAEAVNDKIKLSLVLPHQTIFRSTDVVQVNIPAESGEMGVLANHVPSIEQLKPGLVEIVEEGGASKKFFLSGGFAVVQPDSQLSINAVEGFPLEDFSAENVRAQLAEAQKIASGNGSEQDIAEAKIEIEVLESLQAVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>C8VUH3</accession>
    <name>C8VUH3_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cation transporter, putative (Eurofung)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ANIA_10136</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF88469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050469100.1">
        <property type="nucleotide sequence ID" value="XM_050613271.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VUH3"/>
    <dbReference type="STRING" id="227321.C8VUH3"/>
    <dbReference type="GeneID" id="74896225"/>
    <dbReference type="KEGG" id="ani:ANIA_10136"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN10136"/>
    <dbReference type="eggNOG" id="KOG1341">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005947_4_0_1"/>
    <dbReference type="InParanoid" id="C8VUH3"/>
    <dbReference type="OMA" id="WFQAIAV"/>
    <dbReference type="OrthoDB" id="9999863at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140107">
        <property type="term" value="F:high-affinity potassium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003445">
        <property type="entry name" value="Cat_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015958">
        <property type="entry name" value="Trk1_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051143">
        <property type="entry name" value="TrkH_K-transport"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31064">
        <property type="entry name" value="POTASSIUM TRANSPORT PROTEIN DDB_G0292412-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31064:SF37">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02386">
        <property type="entry name" value="TrkH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002450">
        <property type="entry name" value="K+_transpter_TRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="267"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="310"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="341"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="406"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="469"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="185"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBF88469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="671" mass="74913" checksum="6DCD8DDC266AF611" modified="2009-11-03" version="1">MTRECFLSSPGIGGANCTVHKARRCLRLIASGVSTLLPPFNFLSLHYTYFIVVSLISSLIFWGASNPPRSVSYTDALFMCVSAMTGTGLNSVEASTLTTFQQVIMFVLLMLGHAILISITVLHVRKRAFQHKFKGISHALAQRTAQEAPAPNRNEDKSYPAADNVPMEPPTISSAEINVHFTNTGAQGVSHDQPRKAMVDQPSNLKSENERHRDNYQPINKAQLLQLGIWRGTQKYFESKGLISRNSQFHGLTLEERDRLLGVEYKAVSFLSVIVPLYWVLFLCCGILGMGIWLEVNKPQVPRDNGLSPFWTGAFFAVSAFVNSGMGILDANMTALQTDAYPLITMGLLILAGNTLYPCFLRLIIWSVRRMLPDQQAWKTWRSTLDFILDHPRRVYTNLFPARHTWYLLATVVIFNGIDWAGFEVLSIGNKEIEGLPTAYRIMDGLFQALAVRAGGFSVVTISDLRQGLLVLYVVLLVSAGPAVLIARRHTNVYEERSLGIYAEDETLYGHDKRPPNTVTNFLRRHLFLNKEGTRRHFLREQLKDQLSHDLWWIALAVFLISIMESSNYTKDPVGYSTFNILFEVISAYGCVGISTGYPGRDLSFCGVWHSLSKLILAAVALRGRHRGLPVAIDNAIMLPSESNAQAWAEEENVVSGREHQQVGHLGPGIV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2017-08-30" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>P0DP82</accession>
    <name>XPTB_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Xanthone prenyltransferase B</fullName>
            <ecNumber evidence="3">2.5.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">xptB</name>
        <name type="ORF">AN12402</name>
    </gene>
    <organism>
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2011" name="J. Am. Chem. Soc." volume="133" first="4010" last="4017">
            <title>Genome-based deletion analysis reveals the prenyl xanthone biosynthesis pathway in Aspergillus nidulans.</title>
            <authorList>
                <person name="Sanchez J.F."/>
                <person name="Entwistle R."/>
                <person name="Hung J.H."/>
                <person name="Yaegashi J."/>
                <person name="Jain S."/>
                <person name="Chiang Y.M."/>
                <person name="Wang C.C."/>
                <person name="Oakley B.R."/>
            </authorList>
            <dbReference type="PubMed" id="21351751"/>
            <dbReference type="DOI" id="10.1021/ja1096682"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2012" name="ChemBioChem" volume="13" first="1680" last="1688">
            <title>Genetic and biosynthetic studies of the fungal prenylated xanthone shamixanthone and related metabolites in Aspergillus spp. revisited.</title>
            <authorList>
                <person name="Simpson T.J."/>
            </authorList>
            <dbReference type="PubMed" id="22730213"/>
            <dbReference type="DOI" id="10.1002/cbic.201200014"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>PATHWAY</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2012" name="ChemBioChem" volume="13" first="2764" last="2771">
            <title>New insights into the biosynthesis of prenylated xanthones: Xptb from Aspergillus nidulans catalyses an O-prenylation of xanthones.</title>
            <authorList>
                <person name="Pockrandt D."/>
                <person name="Ludwig L."/>
                <person name="Fan A."/>
                <person name="Koenig G.M."/>
                <person name="Li S.M."/>
            </authorList>
            <dbReference type="PubMed" id="23150454"/>
            <dbReference type="DOI" id="10.1002/cbic.201200545"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>BIOPHYSICOCHEMICAL PROPERTIES</scope>
        <scope>PATHWAY</scope>
    </reference>
    <comment type="function">
        <text evidence="1 2 3">Dehydrogenase involved in the conversion of monodictyphenone to the prenyl xanthones such as emericellin, shamixanthone and epishamixanthone (PubMed:21351751, PubMed:22730213). Monodictyphenone is first converted to variecoxanthone A via a paeciloxanthone intermediate by the consecutive actions of the FAD-dependent monooxygenase mdpD and the xanthone prenyltransferase xptB (PubMed:21351751). XptB catalyzes regular O-prenylation at the hydroxy group of C-7 of the xanthone ring (PubMed:23150454). Variecoxanthone A is further prenylated to emericellin by xptA before being reduced to shamixanthone and epishamixanthone by the dehydrogenase xptC (PubMed:21351751).</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="3">Mn(2+) and Co(2+) strongly enhance prenylation activity (PubMed:23150454).</text>
    </comment>
    <comment type="biophysicochemical properties">
        <kinetics>
            <KM evidence="3">0.327 mM for 1,7-dihydroxy-6-methyl-8-hydroxymethyl-xanthone</KM>
            <KM evidence="3">1.147 mM for 1,7-dihydroxy-6-methylxanthone</KM>
            <KM evidence="3">0.081 mM for 1,7-dihydroxy-6,8-dimethylxanthone</KM>
            <KM evidence="3">0.087 mM for 1,7-dihydroxy-5,6,8-trimethylxanthone</KM>
            <KM evidence="3">0.024 mM for dimethylallyl diphosphate (DMAPP)</KM>
        </kinetics>
    </comment>
    <comment type="pathway">
        <text evidence="1 3">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="1">Impairs the production of the xanthones variecoxanthone A, emericellin, shamixanthone and epishamixanthone; and accumulates several upstream metabolites, including emodin, chrysophanol and monodictyphenone (PubMed:21351751).</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the tryptophan dimethylallyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.-" evidence="3"/>
    <dbReference type="EMBL" id="BN001302">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AACD01000137">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P0DP82"/>
    <dbReference type="SMR" id="P0DP82"/>
    <dbReference type="STRING" id="227321.P0DP82"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN12402"/>
    <dbReference type="InParanoid" id="P0DP82"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009821">
        <property type="term" value="P:alkaloid biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd13929">
        <property type="entry name" value="PT-DMATS_CymD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033964">
        <property type="entry name" value="ABBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012148">
        <property type="entry name" value="ABBA_DMATS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017795">
        <property type="entry name" value="ABBA_NscD-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03429">
        <property type="entry name" value="arom_pren_DMATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40627">
        <property type="entry name" value="INDOLE PRENYLTRANSFERASE TDIB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40627:SF4">
        <property type="entry name" value="PRENYLTRANSFERASE ASQH1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11991">
        <property type="entry name" value="Trp_DMAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000509">
        <property type="entry name" value="Trp_DMAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00036">
        <property type="entry name" value="Aromatic_Prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01162">
        <property type="entry name" value="I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000441130" description="Xanthone prenyltransferase B">
        <location>
            <begin position="1"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000269" key="1">
        <source>
            <dbReference type="PubMed" id="21351751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="22730213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="23150454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="4">
        <source>
            <dbReference type="PubMed" id="21351751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <sequence length="463" mass="52371" checksum="C5B9EC34D18B3A6A" modified="2017-08-30" version="1">MATDGMVLHKRSLSEGGTSTQAWKVLSQTLPSRGPDVDAWWQLTGRHLAVLLDAAAYPIEKQYECLLYHYHYAAPYLGPAPREGASPPTWKSMLQLDGTPFEFSWKWNNPGGEPDVRFGLEPIGPMAGTSLDPLNHLAMREILYKLSSAVPGSDLTWTHHFLATLFDHDYAKYTQKAATMGSSIGTSLVYSLEFQRKSTGLKTYFHPRKLDQQAFLDIPSWEASFRGLHPNSPSRTAVHEFLSTNPEGKLLKPFCLSVDNCSPAKARIKWYFNSPHTNFRAIREIMTLGGRIADTETRTKQFSELFNLLKTVTEEHADFPETSEFPYVPNNGDSIIPNFADAPDMLKGCVYFFDIAPGRNLPAIKVYFPVRNHCRNDLAVTQNLNRWLESRGRGQYGAAFGRALETIADYRRLEDSGGLLSFLSCQFMEDGELDLTSYFNPQAFHSGRLTHRRATRRRGDDRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="102" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AQN8</accession>
    <accession>C8VRJ5</accession>
    <name>Q5AQN8_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter, putative (AFU_orthologue AFUA_3G04010)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ANIA_09392</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF87526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_682661.1">
        <property type="nucleotide sequence ID" value="XM_677569.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AQN8"/>
    <dbReference type="GeneID" id="2867848"/>
    <dbReference type="KEGG" id="ani:ANIA_09392"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_0_1_1"/>
    <dbReference type="InParanoid" id="Q5AQN8"/>
    <dbReference type="OMA" id="AKLHMNA"/>
    <dbReference type="OrthoDB" id="9971669at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000188">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF67">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G04010)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="216"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="241"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="276"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="309"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="426"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="452"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="484"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="517"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="150"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBF87526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="568" mass="63132" checksum="3A3F71B50AD2E8FF" modified="2005-04-26" version="1">MCPGFMLGCWGYYGGRTASRDLDRKRTVRRRPETNQAAEANQASSVEANAPLLIGEQKNGRGFSFTRSACPSAAYFPLAFSPHPRLSRLAAGTASIVYLRPVPLIPTMDPEKPRAELADDVKQHSLSMTGDADADQKLARRILFKLDTRILPVLALLFLCSFLDRTNVGNAKILGLEDDLDITNHQYDIGLTIFYLFYILSEVPSNLVIKKASPKIWLPALTAVWGIITMCLGFVRNFGSFAAVRALLGIAEGGLLPGMVLYLSSFYRRGDLALRIGLFYTAASLSGAFGGLLARGLAEIGPRGGLEGWRWIMIIEGLLTFLCGCLAYFALPNSIETTPFLTEDERRFARERIQLENPHIQECGPRSRTGELGVVRTADNHRREWLRERCKPNAALDGDTVRRGRRADRRTVFVSFLSDRLKLRGVIMLFSLPIAIAGYAAIGNITSPQAKYGMTFLMATGMYASVPCILVWNSNNSAGHYKRATTSGMQLAIANCGGFVATFIYPNKDKPQFHRGHTVVLSLLVFAWFMILLNVLYCAKINRDKRNGKYSKYEGYSDDRDPKFMMVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ARD4</accession>
    <accession>C8VK52</accession>
    <name>Q5ARD4_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Integral membrane protein (AFU_orthologue AFUA_7G01610)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ANIA_09146</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transient receptor potential (TRP) ion channel family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF82455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_682415.1">
        <property type="nucleotide sequence ID" value="XM_677323.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ARD4"/>
    <dbReference type="STRING" id="227321.Q5ARD4"/>
    <dbReference type="TCDB" id="1.A.131.1.5">
        <property type="family name" value="the putative trp-like channel (p-trpl-ch) family"/>
    </dbReference>
    <dbReference type="GeneID" id="2868046"/>
    <dbReference type="KEGG" id="ani:ANIA_09146"/>
    <dbReference type="eggNOG" id="ENOG502R2RV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004278_0_0_1"/>
    <dbReference type="InParanoid" id="Q5ARD4"/>
    <dbReference type="OMA" id="DIWAGMM"/>
    <dbReference type="OrthoDB" id="5312224at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010308">
        <property type="entry name" value="TRP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040241">
        <property type="entry name" value="TRP_Flc/Pkd2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032800">
        <property type="entry name" value="TRP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31145">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_7G01610)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31145:SF6">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_7G01610)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06011">
        <property type="entry name" value="TRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14558">
        <property type="entry name" value="TRP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01320">
        <property type="entry name" value="TRP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="258"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="391"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="442"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="468"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="550"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="576"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="610"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="domain" description="ML-like" evidence="9">
        <location>
            <begin position="71"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="16"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="760"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="869"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="907"/>
            <end position="1134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="22"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="760"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="839"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="927"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="944"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1058"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1069"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1091"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1116"/>
            <end position="1134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBF82455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="1134" mass="125545" checksum="BA48269CF642BF61" modified="2005-04-26" version="1">MDFDYNARWHEEPWSSTVSHRPQSKQHLGRPSTRQHRKWRDTFRRRPRRRTSFGLGLWWMILVILSVMSSASAALLEFENCLDESIVDSSPRQLQFVPLDVWVTLNMTNSLYPLDVIVYGNVTGTANRSAEYPAPDDPQWDNPNSTFGKIIDLDVDNNNYSTLIASIQVASFTPYSEPSRFCDSVTQGDCPLGPVFYVNETDLSTLRAFSVHHDMVSSYHFSTLHTTFTIISGDAAADRLGCISVSITPDLGSTVKNVLAFVPLSILVLVGLATISAAIYSPWGTTDPFRWTSNYGRDEDVLRLVTPGFGDCLQYIQFVVLTGALSLNYPGYYQPVISQAAWSSLMFNQSFFGTERNPVVDGVYAVNGTRGLDRLERFVGMDGARDLWPGMMVWLCSIVGITILLIQFAFAFRWLYRELARIPEEDLRAKNMPFTVGNVIRIVYNFFLLPLISLSFFQLIVASESPAYCVALAGVVIFILICFSIWIIRLIITTRPRSYLFDDLPTVLLYGPLYNTFSDDAAAYAVIPIFISFARGVAIGAVQASGIAQIVLLAICEVVSVLTIIAFRPFPSPSSMNLYHICISIVRFLTILLSIVFVPSLGISQAARAWIGYVILLLHGLVLVFGFFLNALQTLVEVTARLLGAGGNEAGATRGGLVKLTKFQVFGMRQLSRRLPRRDVVTRQSMASDAAMLAHTDDRLSSQFEGSRPRSLSGSSALLLNRATLNESKGSAIYDAGERSHSRTNSAGLYTPTTLGGFQGSGYQTTGSNSPKIGPIFAMQPHDPYYRPPRPRKRTGFSEDSGRRRSSTLLRDADMDDDAIEGPSISRRGTPTPAYIPAPKDDLDYDEPRRSRKDYAVREVDFYYRVRGPPLSHTGTRKLKTGPADPTGPVSSATGFFRNLFSGKTKDKGKGFEVVRSTRAPPPGLIPEREEVHEPYTDEPGEQDTAHRDKSAPENDSVRHESDRRQDDEHESPQLSLPLIDAGGTIELPSRMGSRRDTQCPPLAPKTPSVSSERRASQGALDRNEDDQGDDSSLRPVQPSARLPFSANSSPSRDRNYSLASTSASISSGHERTAQSRIERPSSVGYVAQHRTRDNIHQGHAEEPSFTESAAELVNETPSEGNRSQPSRASSRYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="101" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AS53</accession>
    <accession>C8VLU5</accession>
    <name>Q5AS53_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ELMO/CED-12 family protein (AFU_orthologue AFUA_8G02810)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ANIA_08877</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF84754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_682146.1">
        <property type="nucleotide sequence ID" value="XM_677054.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AS53"/>
    <dbReference type="STRING" id="227321.Q5AS53"/>
    <dbReference type="GeneID" id="2868165"/>
    <dbReference type="KEGG" id="ani:ANIA_08877"/>
    <dbReference type="eggNOG" id="KOG2999">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009191_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AS53"/>
    <dbReference type="OMA" id="CPHMKDL"/>
    <dbReference type="OrthoDB" id="28413at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017124">
        <property type="term" value="F:SH3 domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048870">
        <property type="term" value="P:cell motility"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024574">
        <property type="entry name" value="ELMO_ARM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006816">
        <property type="entry name" value="ELMO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050868">
        <property type="entry name" value="ELMO_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12771:SF56">
        <property type="entry name" value="CED-12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12771">
        <property type="entry name" value="ENGULFMENT AND CELL MOTILITY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11841">
        <property type="entry name" value="ELMO_ARM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04727">
        <property type="entry name" value="ELMO_CED12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16457">
        <property type="entry name" value="PH_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51335">
        <property type="entry name" value="ELMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="2" id="KW-0581">Phagocytosis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0729">SH3-binding</keyword>
    <feature type="domain" description="ELMO" evidence="5">
        <location>
            <begin position="239"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="248"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="255"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBF84754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="554" mass="63532" checksum="4B135077C2F3ED04" modified="2005-04-26" version="1">MDSNVSELVERLGSEEDAVRKMAVFKLQSSIGDPSFADVFIAEDGLTRLRYLTLHATGNTLAYSLTSFARLLEVDKGWECVDHELVERVVELIVTHPLVNILRGAMSILVSIVSHPSSVGRLSQNAVWGFRALKPAIAIYPQFLEMLVNRLSSADHALCANALQLINSLMRDSITNDSDHEWPKFIQKLQDLGVIKAVYSLMQGTALQDHAHPLIEFQSLTKILLRKWRDTALDLENPEHRRALKGIHLASSQEKGNETGADMRRSKKHSPEKWRRLGFESESPVAQFEDMGFLGMMDLADYVRNHQDEFQKMLLEQSTKPARQRCPIARASLSVTSILYDHFEVDKCETEDSKTYLILESRSNLDKLFKPLLLHWTRLHVAGLHSFFRLWKSTSAELEDYDKIVELVRILIESVVGGAARTKDVQDVEEDLMEFEYSRLRDLQMELLELTYEDAWGQHLRQVREELQHEAAQFVKEQRIRCLLQGAWFPNENISELEGESGSPKWRYVQLSHNRRILHFGDFESMEMNRLDLDVLPGKSEVPLQPAIFELLAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="139" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AS63</accession>
    <accession>C8V9B0</accession>
    <name>Q5AS63_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">serine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Seryl-tRNA synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Seryl-tRNA(Ser) synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">ANIA_08867</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="16">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.11" evidence="2"/>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF77842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_682136.1">
        <property type="nucleotide sequence ID" value="XM_677044.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AS63"/>
    <dbReference type="FunCoup" id="Q5AS63">
        <property type="interactions" value="804"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5AS63"/>
    <dbReference type="GeneID" id="2868363"/>
    <dbReference type="KEGG" id="ani:ANIA_08867"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN8867"/>
    <dbReference type="eggNOG" id="KOG2509">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023797_0_1_1"/>
    <dbReference type="InParanoid" id="Q5AS63"/>
    <dbReference type="OMA" id="GYTPCFR"/>
    <dbReference type="OrthoDB" id="10264585at2759"/>
    <dbReference type="UniPathway" id="UPA00906">
        <property type="reaction ID" value="UER00895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990825">
        <property type="term" value="F:sequence-specific mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0004828">
        <property type="term" value="F:serine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110004">
        <property type="term" value="P:positive regulation of tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0006434">
        <property type="term" value="P:seryl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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        <property type="entry name" value="SerRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Seryl-tRNA synthetase, cytoplasmic"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Serine-tRNA synthetase, tRNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
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    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002317">
        <property type="entry name" value="Ser-tRNA-ligase_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015866">
        <property type="entry name" value="Ser-tRNA-synth_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042103">
        <property type="entry name" value="SerRS_1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033729">
        <property type="entry name" value="SerRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00414">
        <property type="entry name" value="serS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11778">
        <property type="entry name" value="SERYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02403">
        <property type="entry name" value="Seryl_tRNA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001529">
        <property type="entry name" value="Ser-tRNA-synth_IIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00981">
        <property type="entry name" value="TRNASYNTHSER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="tRNA-binding arm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="14">
        <location>
            <begin position="189"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="436"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="66"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="8"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="444"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="464"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
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    <feature type="binding site" evidence="11">
        <location>
            <begin position="272"/>
            <end position="274"/>
        </location>
        <ligand>
            <name>ATP</name>
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        <location>
            <position position="272"/>
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        <ligand>
            <name>L-serine</name>
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            <begin position="288"/>
            <end position="291"/>
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        <ligand>
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        <location>
            <position position="295"/>
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        <ligand>
            <name>L-serine</name>
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    <feature type="binding site" evidence="11">
        <location>
            <begin position="359"/>
            <end position="362"/>
        </location>
        <ligand>
            <name>ATP</name>
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    <feature type="binding site" evidence="10">
        <location>
            <position position="395"/>
        </location>
        <ligand>
            <name>L-serine</name>
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    <feature type="site" description="Important for serine binding" evidence="10">
        <location>
            <position position="397"/>
        </location>
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        <source>
            <dbReference type="ARBA" id="ARBA00010728"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012840"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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            <dbReference type="ARBA" id="ARBA00031113"/>
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            <dbReference type="ARBA" id="ARBA00034892"/>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="PIRSR" id="PIRSR001529-2"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CBF77842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="474" mass="54045" checksum="20157B99F4A2E50A" modified="2005-04-26" version="1">MLDLADFITDRGGDPNKIKESQRRRSAPEAAVDEVITLYEEARKARYEVSQINSKLNGLLREIGKKKKNKEDATSLLEEKAKLESQRKEAESVALQKEDLRDKKIRTIGNYVHDSVPVSNNEDDNSVIRTWFPEGFVAEKPNCLSHHEVLTRLDGYDPERGVKVVGHRGYCLTGYGLFLNLALVNYGLEFLWKRGYKPNQPPHFMLREMMAKTAQLEQFDEELYKVTESEDKSTDKYLIATSEQPLSALHDSEWLQDKDLPIRYAGYSTCYRKEAGAHGKDAWGIFRVHQFEKIEQFVLTKPEDSWKAFDEMISTSEEFYKSLGLPYQVVSIVSGALNNAAAKKYDLEAWFPFQQEYKELVSCSNCTDYQARALGIRYGPKKTTDAKKSYVHALNATLCATERTLCCVLENYQTEDGFIVPEPLRKYIPGAPEFLPYTKELPKDSTSTKARSKPTTKSASGADEVSRNLKDMQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="108" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ASD1</accession>
    <accession>C8V9N9</accession>
    <name>Q5ASD1_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61</fullName>
            <ecNumber evidence="2">2.1.1.220</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit trm61</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9 13">tRNA(m1A58)-methyltransferase subunit TRM61</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">ANIA_08799</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="17">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalytic subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Heterotetramer; composed of two copies of TRM6 and two copies of TRM61.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.1.1.220" evidence="2"/>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF77998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_682068.1">
        <property type="nucleotide sequence ID" value="XM_676976.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ASD1"/>
    <dbReference type="FunCoup" id="Q5ASD1">
        <property type="interactions" value="626"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5ASD1"/>
    <dbReference type="GeneID" id="2868347"/>
    <dbReference type="KEGG" id="ani:ANIA_08799"/>
    <dbReference type="eggNOG" id="KOG2915">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025402_2_0_1"/>
    <dbReference type="InParanoid" id="Q5ASD1"/>
    <dbReference type="OMA" id="IGQPWGS"/>
    <dbReference type="OrthoDB" id="1925287at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031515">
        <property type="term" value="C:tRNA (m1A) methyltransferase complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160107">
        <property type="term" value="F:tRNA (adenine(58)-N1)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000189">
        <property type="entry name" value="tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.330.20:FF:000005">
        <property type="entry name" value="tRNA (Adenine-N(1)-)-methyltransferase catalytic subunit trm61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049470">
        <property type="entry name" value="TRM61_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014816">
        <property type="entry name" value="tRNA_MeTrfase_Gcd14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12133">
        <property type="entry name" value="TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12133:SF2">
        <property type="entry name" value="TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE CATALYTIC SUBUNIT TRMT61A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08704">
        <property type="entry name" value="GCD14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51620">
        <property type="entry name" value="SAM_TRM61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 16" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61 C-terminal" evidence="15">
        <location>
            <begin position="121"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="76"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="374"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="456"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="385"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="491"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00054081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00063447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00067592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00077998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF08704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CBF77998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="502" mass="56078" checksum="B6DCE49C9E7D7CF2" modified="2005-04-26" version="1">MPSPFLSPSAHSQLDQLALLHLRRDNTIPAILRLHDEENLGYKEGNVTNTRFGSFPHSTLFDKPWGSQIIASKVDTGSRGRAQLKKRKANQLDSASGTGGDEDGTESSKLTREAPVAAASGFLHILCPTPELWTASLPHRTQVVYTPDYSYVLHRLGVRPGSTLIEAGAGSGSFTHAAVRAVFNGYPDITPPPTKRRRRLGKVCSFEFHAQRAGKIRDEIHDHGLDGLVEVTHRDVYQDGFLLNDPDGKPSTSPKANAIFLDLPAPWLALKHLVRNSPSGAESPLDPNTPVHICTFSPCMEQVQRTISALRQNGWLHISMVELQHRRIEVKREKTGLEFEGVRGANVFPRNIDDAVQKMRVVEQRSIRFRDVVGQVEQDQDQQDESTAQRRQSQTQTPSELPTFIPPTHYKDIPPYAQGRLVHRSEPDLKTHTSYLVFAVLPREWSEEDERKCVEKWPSQTVDEEAAQPAKAKSRRQMKKEAKAAAGGVNKAEEANRYENEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="109" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ATA4</accession>
    <accession>C8VEI8</accession>
    <name>Q5ATA4_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Xaa-Pro dipeptidyl-peptidase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_08476</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF80628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_681745.1">
        <property type="nucleotide sequence ID" value="XM_676653.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ATA4"/>
    <dbReference type="ESTHER" id="emeni-q5ata4">
        <property type="family name" value="Cocaine_esterase"/>
    </dbReference>
    <dbReference type="GeneID" id="2868796"/>
    <dbReference type="KEGG" id="ani:ANIA_08476"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN8476"/>
    <dbReference type="eggNOG" id="ENOG502RPGM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015590_3_0_1"/>
    <dbReference type="InParanoid" id="Q5ATA4"/>
    <dbReference type="OMA" id="NGGIEDF"/>
    <dbReference type="OrthoDB" id="2578740at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3020.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005674">
        <property type="entry name" value="CocE/Ser_esterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000383">
        <property type="entry name" value="Xaa-Pro-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013736">
        <property type="entry name" value="Xaa-Pro_dipept_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050585">
        <property type="entry name" value="Xaa-Pro_dipeptidyl-ppase/CocE"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00976">
        <property type="entry name" value="CocE_NonD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43056:SF10">
        <property type="entry name" value="COCE_NOND FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G00600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43056">
        <property type="entry name" value="PEPTIDASE S9 PROLYL OLIGOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02129">
        <property type="entry name" value="Peptidase_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08530">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00939">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xaa-Pro dipeptidyl-peptidase C-terminal" evidence="2">
        <location>
            <begin position="327"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF80628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="591" mass="66558" checksum="94E6B99DD3901EDF" modified="2005-04-26" version="1">MPPPVQAAYKRIKPPQAGENGYVPPQPGKTEILDAGWNGFNAKPLTSPILIEHDVELVVRDGARLYADIYRPPSSNDNVKVPAILSWSFYGKKYSALDMLPMCVWNCCVPRSDLSGLEKFEGLDPATWCPRGYAIVSVDTRGAGHSDGLIGVMGAQDAEDGYDVVEALAKMPWCNGAIGMAGNSALAISQWFIAAQQPPSLKAIAPWEGSADIYREQFCRGGWFSMSNFDLITNEIVRGPPSSGIEDFEEMYRRSNVSSPFWEDKRADLTRVQCPAYIRGSDVSSIHTMGSIRGWLEVPHDKKWIQWGSRQEWYELYSCPESMDELGRFFDRYLKGIENGWEQATPRVRWSALQFGDREAIDNIVLEDFPMPKTQYRELFLSKNKLNESPGSDYEIVSYNSESSSDFAEFSFTFMQDSRLIGLPKAILYMSCEDRDDFTVFVIIRKKDKNGKPLMHLNFPFHATPVASIEEIPPKEQASLNLHPGSVGILRASHRAFDPEKSIHPQFPFHPHTRQEKVKPGEIVKLEIGIWAMGVDFEAGETVSIRVSGQYPSIAEYKTWSRPRPEHELNRGKHFIHCGGECPSSVILPFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ATL4</accession>
    <accession>C8VE60</accession>
    <name>Q5ATL4_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ANIA_08366</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF80392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_681635.1">
        <property type="nucleotide sequence ID" value="XM_676543.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ATL4"/>
    <dbReference type="GeneID" id="2868773"/>
    <dbReference type="KEGG" id="ani:ANIA_08366"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN8366"/>
    <dbReference type="eggNOG" id="KOG2504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_1_1_1"/>
    <dbReference type="InParanoid" id="Q5ATL4"/>
    <dbReference type="OMA" id="WIGSIQC"/>
    <dbReference type="OrthoDB" id="6509908at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF234">
        <property type="entry name" value="MFS-TYPE TRANSPORTER DBAD-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="49"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="251"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="319"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="343"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="375"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="412"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="5">
        <location>
            <begin position="50"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="8"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBF80392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="443" mass="47281" checksum="93AB705CE14371DC" modified="2005-04-26" version="1">MGDRLQPVDQQVVTEKNPNNNDQEPTPKTSTDQLPKGPIGPSPPPNGGLVAWLHVVAGFMLFFNTWGLLNTFGVFQTYYESGTLFRRSSSDISWIGSVQAFMLLLVGFITGPIYDRGYLRTLLTVGSFGIVFGTMMLSLCKEYWQVLLAQGFCVGIGAGCLFVPCVSILPTYFSSKLGAALGLAVAGSSLGGIIYPIVLNRLLSPLGFGWAVRVIGFIALGTLLLPIVIMKQRVKPPKARALIDWTAFTDIPFMTLVIAGLIAFMGLFTLLFYISYVASARHLTSNDMAFYLVPILNAASCFGRTIPTAMADKFGPFNLIGPFCMVVGVLILCMMAVVNEAGIIVIAVFAGFFSGALIGLPPLCFVALTKDKSKIGTRLGMGFGIMAFGVLAGGPGAGDILGDTHDLDWNGVWIFGGASCLAAAAIFAGLRVSQYGFKLRVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ATL9</accession>
    <accession>C8VE55</accession>
    <name>Q5ATL9_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_08361</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF80383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_681630.1">
        <property type="nucleotide sequence ID" value="XM_676538.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ATL9"/>
    <dbReference type="GeneID" id="2868837"/>
    <dbReference type="KEGG" id="ani:ANIA_08361"/>
    <dbReference type="eggNOG" id="ENOG502SHT7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012014_1_0_1"/>
    <dbReference type="InParanoid" id="Q5ATL9"/>
    <dbReference type="OMA" id="DMSMRTW"/>
    <dbReference type="OrthoDB" id="4721035at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="125"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="170"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="696"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="745"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF80383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="769" mass="84629" checksum="06A451B216569FDC" modified="2005-04-26" version="1">MAPAAKDYRLPPLPEFVSSWNPVDLGDRSNIRYEHAPNDDEADDHPVRPVGLGISQPAGHSRSTSYDTTQTTATTPDPASSRFVNSETSLLGERERSHSRVQSQSQSHLVKCPTKKTIVHRRLSWVPATILVLAFYSTIFSGIYLVVAFIKPRYGRFIGVDGKLAASTATLLSTLFAKTIELAYVTVCVAFLGQVLTRRAITKGSRGISISDMSMRTWIMQPGSLIVHWESLRYSGWTILGAITLTATVVAMLYTTAAEALVTPKLKWGAVEERVIVGNVWTSFANADYLADNCETPVAIQDDLEFRNTTCLNMQHAGQAYNNYQSFIKEWASIAEGIQPSPTDAASRPRPTGSVYDNTTVEGSWVDRVSIADLAEKYGRIVHNVTAAMPHGGIIGAANHPDNKIIQPKDQSGEGMYELEASVPSPAVNVLCAGMNATELAPIVYNEWPNHGNFNAVSWTTNVPDDVPNIEHWHNRTVVDDIFEFGPDYPDQYAPVFGKLPEEFNTIVNVTSPYSNGAIFLLGASPNGTKPEYFLCRLKAKQSTRCSTRYKATATGSHLYTVCNENQPLQYDLRVPDAVESWANDWMYIASEWSFTLSLNAGITDGAAANARLLMQFAPTARTLNPKLPTLSEALAVLAGNTLLMASANAPFVPFWNYTNTYPETNILKTPEKQYINATLRAIEYASGGTQKWQGIFYPILLFAFFTSALCLAFMLLEIRGKQITDFTEPQNLFALAMNSPSTTKLQGACGSGPAGKQLGERWRRRARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="104" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ATU2</accession>
    <accession>C8V3R1</accession>
    <name>Q5ATU2_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">phosphoinositide 5-phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.36</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ANIA_08288</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the synaptojanin family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the central section; belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.36" evidence="4"/>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF74285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_681557.1">
        <property type="nucleotide sequence ID" value="XM_676465.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ATU2"/>
    <dbReference type="FunCoup" id="Q5ATU2">
        <property type="interactions" value="363"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5ATU2"/>
    <dbReference type="GeneID" id="2868969"/>
    <dbReference type="KEGG" id="ani:ANIA_08288"/>
    <dbReference type="eggNOG" id="KOG0566">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003016_2_1_1"/>
    <dbReference type="InParanoid" id="Q5ATU2"/>
    <dbReference type="OMA" id="HPCHELR"/>
    <dbReference type="OrthoDB" id="405996at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052658">
        <property type="term" value="F:inositol-1,4,5-trisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043813">
        <property type="term" value="F:phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004439">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.10.10:FF:000029">
        <property type="entry name" value="Inositol polyphosphate 5-phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046985">
        <property type="entry name" value="IP5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000300">
        <property type="entry name" value="IPPc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002013">
        <property type="entry name" value="SAC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200">
        <property type="entry name" value="INOSITOL 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200:SF257">
        <property type="entry name" value="PHOSPHOINOSITIDE 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22669">
        <property type="entry name" value="Exo_endo_phos2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02383">
        <property type="entry name" value="Syja_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00128">
        <property type="entry name" value="IPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50275">
        <property type="entry name" value="SAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SAC" evidence="10">
        <location>
            <begin position="148"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1019"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1020"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1057"/>
            <end position="1071"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CBF74285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="1106" mass="123519" checksum="AB7490F48C299C4B" modified="2005-04-26" version="1">MPSIRVFSRDHPVRTLILATSDDALVFQHSLRESANNHSSVNHDRQRCLVKFASLSSIDLASYRPLGSGYGTLGLVTIDHDVFVCVVTRSSKAATVRPGETVLRIEDVDLYCLNRSEYEFTPYYDAESSVNEDTISNTLPAKDPFLALKKLLTDGSFYYSLDFNLTDRLQDRSDKLTAFDIDSLDKDVLWNAYMIQPLLMFRSHLPPYEKQLLDASQILTCVIRGFCGTIAIPANANVLHSEPKAHLPSMLTLISRLSSRRAGTRFNARGLDDDGNVANFVETETILVCGTSGVAFSYVQVRGSVPIFWEQATGFLPGQQKIEVTRSIEATQHAFDKHIQFLELEYGAVHVVNLLCESKPGEIELSTRFREHIRRNLSSKKSNLPSDHALLRTTEFDFHAEARGPLGYGAGNQIKHELTQSLNGFAYFLSKQNRPSEIPGTSVVLQQEGVFRTNCLDCLDRTNLVQTIISLLALESFLSQENSVLYSEVHHRHSILWADNGDALSKIYAGTGALKSSYTRHGKMSIAGALADARKTAARLYINNFSDKARQRTIDLMLGLLPDQLPVHLYDPINDMVSAKLDRISSEFTSKKLADIWTGTFNVNGRVQGPGTDLSPWLFPEDNDQRKCPTIFAVGFQEIVTLSPQQIMSTDPTTRKSWELAVMDCLNSRAAARGSPKYVLLRSGQLVGTALMIYVREDILRDIKNVEGSVKKTGLSGIAGNKGGCAIRFEYSNTRLCFVTAHLAAGFANYDERNNDYETICQGLRFQRNRFIEDHDAVIWLGDFNYRIGLPNQTVRDLVRQSNYQKLYDNDQLNLQMLAGRAFQFYSEGLVTFPPTYKYDVGSDTYDTSDKSRIPAWCDRILWKGPDLRQSGYGASDMRLSDHRPVWATFTCTISIVDETRKESLRQSLHAQQWSKSQTVGTQITQSMRTDDNVLIPVEPTATGLPPPSSEHRKWWLDNGAPVKSSIRPPAKDYILNEHRTSNPFSYSESEKLEWVPIVATQRKFMVTGGAISRKPLVPPRSAAASVSPRSLQNKPLKAEEHQKAYSPPIPAKPSSLALNQSTPLPRQSASACGDATLPIASGSSLPTALLDDDVNVEFNWQPLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AU56</accession>
    <accession>C8V6Y7</accession>
    <name>Q5AU56_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_08174</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF74035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_681443.1">
        <property type="nucleotide sequence ID" value="XM_676351.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AU56"/>
    <dbReference type="GeneID" id="2869320"/>
    <dbReference type="KEGG" id="ani:ANIA_08174"/>
    <dbReference type="eggNOG" id="ENOG502RZ6R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_383106_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AU56"/>
    <dbReference type="OMA" id="SGRSMKM"/>
    <dbReference type="OrthoDB" id="3692311at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030175723" evidence="2">
        <location>
            <begin position="30"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="235"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="621"/>
            <end position="644"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF74035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="722" mass="78727" checksum="77A2149FC5D2E729" modified="2005-04-26" version="1">MSAAIALPLLNSIGCCLLLSVSNRRPVSPNPHLDSNAGSYSVGFKDIPQTMGVSQLNYPVALHCLGIRKGRGPMAVSLNSRDDMSSVPLQVEAPFKTTFSNRISVKARQDSGRTLRKPAGSIFALVFEGFLCLIALCFIGTHLTSKRPFLTTSLITEYGHVALALVALCIRNRPTGDSLGSAMEQAMRLGPTIYPILFAALLSRSLKSIGRYCAQRSVRMSKLWALMNTNATADPILHLVSMPASILVWGLLVLWIMSPLGGQSTIRLLYKANITNETHPELRYWDSGPLGNMFINVGIMEGNDGSWPLSMRDIYSASLMQSVSTKAGPLDQWGNVKIPRIEAGNESQVDSAGWMPIKKSLGAETFTSLFGMPIVGLSDMKKQGDLNLTIEATYVVLSEPSTYSTSNPRTLRFNNTVGDTTVTTCQVTQRMVEAFIECVDGSCEATKVRPSTTDLRDKNFTSFDYWAWIVLDMLTSVGSQKPQREVMWGVGSSVLFLNDSSSFLMQTGISGSQAEVNISNIDPELFSTRASILLNTGLQAFMAPTGFSGELPTNLSLYGVPHVPGRGLQAMANQTALDTFEYTVYAPPKQLLNMLNDLAPFVGASTNATFVRYTEVYRPDYVWAVILIISSVLLFGVGVAGICVRFKTFAPNMFDPVAALTYSNPYISLTGREYDPLDADERANLLGDKRVQIGEVDDYKGVKAVFGEAGYVTPLRLGIPYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="115" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AUC2</accession>
    <accession>C8V6L9</accession>
    <name>Q5AUC2_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Fumarylacetoacetase</fullName>
            <ecNumber evidence="3 13">3.7.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Fumarylacetoacetate hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">ANIA_08108</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="18">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>4-fumarylacetoacetate + H2O = acetoacetate + fumarate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10244"/>
            <dbReference type="ChEBI" id="CHEBI:13705"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18034"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="EC" id="3.7.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="13">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1 13">Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 6/6.</text>
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    <comment type="similarity">
        <text evidence="2 13">Belongs to the FAH family.</text>
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        <property type="protein sequence ID" value="CBF73904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_676285.1"/>
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    <dbReference type="VEuPathDB" id="FungiDB:AN8108"/>
    <dbReference type="eggNOG" id="KOG2843">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_026207_2_0_1"/>
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        <property type="reaction ID" value="UER00341"/>
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        <property type="component" value="Chromosome II"/>
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        <property type="term" value="F:metal ion binding"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="P:homogentisate catabolic process"/>
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        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
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        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
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        <property type="entry name" value="Fumarylacetoacetase_N_sf"/>
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        <property type="entry name" value="FAA_hydrolase"/>
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    <dbReference type="SUPFAM" id="SSF63433">
        <property type="entry name" value="Fumarylacetoacetate hydrolase, FAH, N-terminal domain"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12 13" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 13 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 12 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 13" id="KW-0585">Phenylalanine catabolism</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13" id="KW-0828">Tyrosine catabolism</keyword>
    <feature type="domain" description="Fumarylacetoacetase N-terminal" evidence="16">
        <location>
            <begin position="13"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="Fumarylacetoacetase-like C-terminal" evidence="15">
        <location>
            <begin position="116"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="304"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="305"/>
            <end position="322"/>
        </location>
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    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="118"/>
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        <ligand>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="193"/>
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        <ligand>
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        <location>
            <position position="195"/>
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        <ligand>
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        <location>
            <position position="229"/>
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        <ligand>
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        </ligand>
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    <feature type="binding site" evidence="12">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
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    <feature type="binding site" evidence="11">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>substrate</name>
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    <feature type="binding site" evidence="12">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
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    <feature type="binding site" evidence="12">
        <location>
            <position position="253"/>
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        <ligand>
            <name>Mg(2+)</name>
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        <location>
            <position position="367"/>
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        <ligand>
            <name>substrate</name>
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        <source>
            <dbReference type="ARBA" id="ARBA00004782"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00010211"/>
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        <source>
            <dbReference type="PIRSR" id="PIRSR605959-3"/>
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        <source>
            <dbReference type="RuleBase" id="RU366008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF09298"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CBF73904.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
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    <sequence length="435" mass="46126" checksum="1AA1A4DC416E0582" modified="2005-04-26" version="1">MTSPAYAHHFSIKNLPYGVASSPTHGQQCATRLHNTVIFLGDLQNSGFFGDISLPNGIFMNSTLNGYAALPKSVHTAVRATLQSVLGESGLNGLPENSKADITTVKLHLPVEILGFTDFSNSLNHVQNAGRAILNDPSPPPGFFHFPIGYTGRASTVVVSGTPITRPCGHFYDRSNPVARKVVYGPSRALDYEMELGVVVGRPFGWGSAEGIPATDAEEYVFGFVVLNDWSARDIQGLEMVPLGPLNGKAFGTTVSPWIVTTDALAPFKVAGPEPRVELEEHLKDEKEGNFDIVMKVEIIHPPAGQSTSSAATNSNEGAGNNTEDKSVSHIATSAAKELFWNHRQMIAHLTSCGSDLRTGDLLGTGTVSGSLEGSYGCLLESTKGGKQAVTLADGGERVYLLDGDIVRMSAFLGDEASGVGFGECTGEIYPVISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="106" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AUS2</accession>
    <accession>C8V593</accession>
    <name>Q5AUS2_EMENI</name>
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        <submittedName>
            <fullName evidence="8">GABA transporter, putative (Eurofung)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ANIA_07958</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF73597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_676135.1"/>
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    <dbReference type="AlphaFoldDB" id="Q5AUS2"/>
    <dbReference type="GeneID" id="2869114"/>
    <dbReference type="KEGG" id="ani:ANIA_07958"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN7958"/>
    <dbReference type="eggNOG" id="KOG1289">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004495_6_2_1"/>
    <dbReference type="InParanoid" id="Q5AUS2"/>
    <dbReference type="OMA" id="SNAFVWD"/>
    <dbReference type="OrthoDB" id="3257095at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015185">
        <property type="term" value="F:gamma-aminobutyric acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015812">
        <property type="term" value="P:gamma-aminobutyric acid transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF5">
        <property type="entry name" value="GABA TRANSPORTER (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="68"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="162"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="220"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="259"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="364"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="388"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="435"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="465"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="11"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBF73597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="499" mass="54279" checksum="76BBB4DDCB91EFC2" modified="2005-04-26" version="1">MPLTSVAGAGTERKTASTREVTQRDPDTMEAQRGGGSADDSGRTLAPEDDRFGDAHISYREKQRLDRYLSFLPSLFFSLTLLASWETVAGGLLAGLYNGGPAAIVYGLLVSIVGNMAIAMSLAELASVHPTAGAQYHWTYVLAPWHPRFFSFFQVNIFARRCLGVIETVAGIMHIVILPMIIGVLGRSAVSSNESHNSIEDANNFVWDTFLSGFSGWKDAGVVFSVGLLGVITPLSGVDGIIHMSEEVHNARLTIPRSMVWGTLLNGIMALGYAIAILYFMGPSPEAYASALLTSTGYPIIEITYRVTGSKAATFMLIATGMSSGWIAFFNGLASVTRLMWAFARDNGLPFSDFFVKVDRRLKIPLRALGLVTGWIFVLSFMQMGSTAAFNGIMSLSALGLYISYLFPLSFLVWGRLKGDVPSGAYSLGRWGLTLNLVAILFATYFAVFLPFPPTLPVTPENMNFSGPVLGFIMLCSCVDWVARGRHKWTGPTMRYPRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AV33</accession>
    <accession>C8VDX6</accession>
    <name>Q5AV33_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">LysM domain protein, putative (AFU_orthologue AFUA_5G03980)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ANIA_07847</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF80232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_681116.1">
        <property type="nucleotide sequence ID" value="XM_676024.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AV33"/>
    <dbReference type="STRING" id="227321.Q5AV33"/>
    <dbReference type="GeneID" id="2869662"/>
    <dbReference type="KEGG" id="ani:ANIA_07847"/>
    <dbReference type="eggNOG" id="KOG2806">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_423906_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AV33"/>
    <dbReference type="OMA" id="WNSEINT"/>
    <dbReference type="OrthoDB" id="5985073at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052210">
        <property type="entry name" value="LysM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34997">
        <property type="entry name" value="AM15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34997:SF2">
        <property type="entry name" value="LYSM DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010241343" evidence="5">
        <location>
            <begin position="19"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="6">
        <location>
            <begin position="28"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="6">
        <location>
            <begin position="128"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="6">
        <location>
            <begin position="210"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="6">
        <location>
            <begin position="296"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="82"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="262"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="82"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBF80232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="646" mass="70049" checksum="502D63EB113CCC20" modified="2005-04-26" version="1">MQLVHLLAAGLIPALVSALLRRDVDCLFATTPANGATCQSFASNWGLSVSEFQELNPGTTCPDIDTSKAYCVVGTVTADAPGTTLTTTTSTSTTTTPTNTTTTTQPPTAANPTVPTPTMPGIVDNCDSFYKVSSGDQCDNISQRHSITTAQLRSWNSEINTDCTNLWLDYYICIHVPGATTTSLTTTTTTNAIVTGPTPQQTGIISNCNKYHLVESGDGCASIASAYGISLSNFYSWNPAVGSSCGALWLGYYVCVGTSSSQPTPTSTTSQTTTATATTAPGPSPTQSGLIKTCTSYYKAQVGDTCQAIVQEKYPYVNSLTLFVRWNPAVGSSCSNLLAGYYYCVATELHQPMPGINGRLELERNQSVMAASPVGRPGRRKSEIVAEVMISRKWPSIVPRTPSFVEHFRPFVHLSSLTFQRPPPVDSLFVYLSLFAAGPLKCDLFVSAFLVIEVDTHASQLVNQFGGRLIRLISLYVEQSSSVLEGAKKGGHIRWHILAEDQTQLSSNYRDGCLKTYSIKFWLDESVQGVVPSVLDKSELRKFGRDLGVGLDEIRKLRLDQVVWVCQWLQDAGMIECFEVQENQATAEVNPLEPLGLCPPCCVCPRPAMAQCLSLSLRGHPQPNCYIVPGQEFFLDQEDRGVNFCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AVF2</accession>
    <accession>C8VDJ2</accession>
    <name>Q5AVF2_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ANIA_07728</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF79984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_680997.1">
        <property type="nucleotide sequence ID" value="XM_675905.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AVF2"/>
    <dbReference type="GeneID" id="2869746"/>
    <dbReference type="KEGG" id="ani:ANIA_07728"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN7728"/>
    <dbReference type="HOGENOM" id="CLU_1151785_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AVF2"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF79984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="241" mass="26395" checksum="5383156C899442E9" modified="2005-04-26" version="1">METYKVPSSALIGVAVPTSSPSASLPEIHRRVIAPFPVFVSVASRTLEKYADPLVADWLIGSLDRRKHMGVGLCKFKQTPAAEPYAAGSGEEVRSLGPGADLWGHAYLILQASHLTCTKHVRGSTCSIPVSGRMHCCIVAMLRIDLDLDPSGRDPSINSSQVLIQPGSRAGWLDRIERYPEFGCGQETCFDQNKKGGWLSSLEKLLRAPPTAEQVYSVLTLADQRTHWELRIAVGLTEYYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AVH8</accession>
    <accession>C8VC64</accession>
    <name>Q5AVH8_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Oligopeptide transporter, putative (AFU_orthologue AFUA_6G03140)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ANIA_07702</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF79935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_680971.1">
        <property type="nucleotide sequence ID" value="XM_675879.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AVH8"/>
    <dbReference type="GeneID" id="2869523"/>
    <dbReference type="KEGG" id="ani:ANIA_07702"/>
    <dbReference type="eggNOG" id="KOG2262">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004965_3_2_1"/>
    <dbReference type="InParanoid" id="Q5AVH8"/>
    <dbReference type="OMA" id="QLAYRII"/>
    <dbReference type="OrthoDB" id="9986677at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="251"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="288"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="318"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="389"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="413"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="570"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="602"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="648"/>
            <end position="671"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBF79935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="695" mass="78129" checksum="CBC23F6EF1AA9DA9" modified="2005-04-26" version="1">MAQFTVRRGAEAQQNDKDICSSAFKACSKLTKPAQLHGAEELSAEKVQSPETEAYTEADSADESQYYFDSAEFKNIPDLVRTVVGFEDDPSLPVLTFRSILLSAISCTLGSIVSQLTYFRTTTAPFPVFFVIQASDPLDRFLARILPAYKVPLGRVSFSLNPGPWSPKEHAIVGIAANAGSRGQWANYAYQTRAHLYSGLHSPQWAYPVRATLIDDPEFIFPLSLQQVTLYRSMDTRNRTGKKRALDQMKVFWILLLATFVWQFLPEYLFPFVASLAPLCWIASRNHMVNFIGAGRGGMGLLNITLNWSNIASVVITYLYSVQAIICLAFVLTCWILIPIADSGKLWGSPAYDIMSNGVFQKNGSAYPFNDLSKLVRSLTIEAEDNREWAALTLVPIVMLFGIVVSKKIYMPIWTYFVALGFGAAAMLPMSFVYAMPGFSIKVGYLNELIYGYMIEAKGSSRHPLGQLAYRIISGNVWYDARTVLEDQKIGHYLHLPPRQVVGIQIIANMLALPVNYGVTRWVLATKFEYVSGQKTDPLVQWTGHEFQSYNTAGIQYALVGPKKLFASDFFRPILWGFLAGAVAPILMWLLHRRFPRARFDLWNTTIFFASAAVFYGNLSTGPFTTFLVGTFTNFYLFRYRRVFWNKWAYISGAATDTGFNANLLFIFIFLGSTGTKMVHWWGNNADSVERCFAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AW91</accession>
    <accession>C8VBB3</accession>
    <name>Q5AW91_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA polymerase epsilon subunit B</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">DNA polymerase II subunit 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ANIA_07439</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA polymerase epsilon subunit B family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF79384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_680708.1">
        <property type="nucleotide sequence ID" value="XM_675616.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AW91"/>
    <dbReference type="FunCoup" id="Q5AW91">
        <property type="interactions" value="750"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5AW91"/>
    <dbReference type="GeneID" id="2869644"/>
    <dbReference type="KEGG" id="ani:ANIA_07439"/>
    <dbReference type="eggNOG" id="KOG3818">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010628_1_0_1"/>
    <dbReference type="InParanoid" id="Q5AW91"/>
    <dbReference type="OMA" id="PEDGAWF"/>
    <dbReference type="OrthoDB" id="10254730at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008622">
        <property type="term" value="C:epsilon DNA polymerase complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007185">
        <property type="entry name" value="DNA_pol_a/d/e_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016266">
        <property type="entry name" value="POLE2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12708:SF0">
        <property type="entry name" value="DNA POLYMERASE EPSILON SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12708">
        <property type="entry name" value="DNA POLYMERASE EPSILON SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04042">
        <property type="entry name" value="DNA_pol_E_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA polymerase alpha/delta/epsilon subunit B" evidence="9">
        <location>
            <begin position="432"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="129"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="131"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="142"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBF79384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="743" mass="80447" checksum="831CF0599715EFB9" modified="2005-04-26" version="1">MNPDSVPSSSPGFGTPVHPLRSNKLTPIPTRTSVLPILLPPATLRPIAFRTFTRKHNLTLSSSALQSLAGFVGKHCGSGWREEGLAERVLDEVAKSWKKAGGGVIIEEGRGASLKAILETLEGNMSGGRLIDSKSASKEGSTRTTSAGGMLSLQPSMSMMTTIDDQESNKSDDTVIHPRHWIKVIGAFDTPRLAYNAEKKNFEVTKIKPSLFPEPSHKTALFRDRYNLVHQRLLRNELFQVPLASASMPTLQRSSSTFARSQCYKLTPVANLLGRSGTSHLLLGLLSISPTGELSLTDLTGSIVLDLSHARLIPKGGAWLTPGMFVLVDGIYEEEENVRGSTLGGNSGIGGAIGGKFVGVTICGPPCERRETSLGMSIHGKNEDISSSGGFGWVDFTGVGSERAQGSRMRRIQTRCLHEAHDGNQLNRRFKIVIMGEVNLDNMKTMDALRKVFSLYNDSAVQERPLLFVLVGNFVQKAIINGGGQGGSIEYKECFDMLALVLSDFPSLLQRSTFIFVPGDNDPWSSSFSAGASSTIPRYAIPNLFTSRVKRAFASANSQMDRNQLSEPPGEAIWTTNPSRISLFGPVHDIAILRDDISSRLRRNAVTVGHNTADMGGDLSSAVEPEDQIHAGDQQGAGISNQTSPVTLSARKLIKSVLDQGTMSPFPQSVRPILWDYASSLQLYPLPTAFILADPEIAPFCLTYEGCHVMNPARFIPEGGLSTMTTEENAERCVEAAVDVYKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AWI2</accession>
    <accession>C8VCK3</accession>
    <name>Q5AWI2_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Mitochondrial protein from FMP27-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ANIA_07348</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF78570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_680617.1">
        <property type="nucleotide sequence ID" value="XM_675525.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q5AWI2">
        <property type="interactions" value="227"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5AWI2"/>
    <dbReference type="GeneID" id="2869772"/>
    <dbReference type="KEGG" id="ani:ANIA_07348"/>
    <dbReference type="eggNOG" id="KOG1910">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000592_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AWI2"/>
    <dbReference type="OMA" id="IQLKWNN"/>
    <dbReference type="OrthoDB" id="1562405at2759"/>
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        <property type="component" value="Chromosome IV"/>
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    <dbReference type="InterPro" id="IPR019441">
        <property type="entry name" value="FMP27/BLTP2/Hobbit_GFWDK_RBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019415">
        <property type="entry name" value="FMP27_SW_RBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019449">
        <property type="entry name" value="FMP27_WPPW_RBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045167">
        <property type="entry name" value="Hobbit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15678">
        <property type="entry name" value="ANTIGEN MLAA-22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15678:SF6">
        <property type="entry name" value="BRIDGE-LIKE LIPID TRANSFER PROTEIN FAMILY MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10344">
        <property type="entry name" value="Hobbit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01214">
        <property type="entry name" value="Fmp27_GFWDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01215">
        <property type="entry name" value="Fmp27_SW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01216">
        <property type="entry name" value="Fmp27_WPPW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMP27 SW motif-containing RBG unit" evidence="4">
        <location>
            <begin position="1128"/>
            <end position="1230"/>
        </location>
    </feature>
    <feature type="domain" description="FMP27/BLTP2/Hobbit GFWDK motif-containing RBG unit" evidence="3">
        <location>
            <begin position="1248"/>
            <end position="1407"/>
        </location>
    </feature>
    <feature type="domain" description="FMP27 WPPW motif-containing RBG unit" evidence="5">
        <location>
            <begin position="1653"/>
            <end position="2168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="89"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="702"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1054"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1893"/>
            <end position="1927"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2035"/>
            <end position="2059"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2510"/>
            <end position="2563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2742"/>
            <end position="2810"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1830"/>
            <end position="1878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="93"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1058"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1071"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1893"/>
            <end position="1906"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1907"/>
            <end position="1923"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2527"/>
            <end position="2537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2742"/>
            <end position="2760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="2761"/>
            <end position="2777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2780"/>
            <end position="2800"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBF78570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="3043" mass="344665" checksum="E8B73D781D6616A5" modified="2005-04-26" version="1">MTLFNPTTVLVGFLLLYLASFLIFAIVRIATGISIQRIGYFSLRRIAYVPSEGVQIELRGLGLSLHPPSFAQPTWLSLRLTDLKITLDPSASGKRSSSTTKLYTDEAQSQSEDEPLNQQYRKGEAASARKNKTWATFNRVKERVKRIHRMVHWLRLVDIVAVNTTINFLEAGQIQIGTLSMAVDTRRKMVDRGKVFRRKKGESGEQRPAEWILNVHNVQVAVDGNEPIEVLDNVGVNIHGILHKGLDGLRDASVAFKIGRMHIPYDDLTLLVQRIKQSRKPLVQVDVTKPDEEVTFADYVEELKKPGSTDETIVETVTASKEFAGSLLRGIQEIQVALSFFRLSRSVQSPSPGQSSVYLNVVSHEIGIDLHRMDQTSPAHRMYFQRTDVAHQALLAAISLSVSLDDSSGETDNILYIPMATTTIKTTLPSKTLSSYDGFNAEERNTNILFANLVVTSPALDLEPRHVSRLLGLAQTKASTSRGKKRARGQLISRLLPKANIKLSVHEPVVRFVLPIPDSSSTGEDDYNLLISSISSISVDVESSHSSEGGAHYSLSSIYRVASHKFYYQTPSGIKHNLLTTDNMELKLLLSASPEVCVVVSGSLNNFSGHMVNSEVNRGIQQVVEQFRAQIRPKKKYGLPGEDRKPSILRRLPPWLLRFQFEATGFSLEIAGVDESVSKVTRGVSLQLQSWTADYRAQKTEPTAVSVVRRRTPSHSTIGDESPFRFNPTSPPKQTRPGAADGRRLAFHARGFEGFVIESEDYLESEPFLSLPRFEIALSTSSDRLGPIFHVNSLIKGVYLQYSLYRYYCLSVALSVLQKAFLPSSQKQPSSPNVAGDTSPPLSPRLAIQRGELITVDIKATVLQVKTFMPADPPMLLQVYGVTAGSHRHSAPFVRAHLVRLHAEAPKLRGVWARIVSMNNFRLDLRKMKLKQGKSLVEDKSIDVWTDFVRIGVPHHMIMHRIFDNVINTSKALKQLHHRLKHQIPDFVSARDPEGPKKVPKISFRSKALLFELEDDAFEWKLGCIYRTGLIEQRQRRAREDAFHLKLQKLKESDQRRASSRLRTRSSHRTLRSERVSSDSRRSKSADPKPRNDRAEEKEEKRGRAHRFRYDTEGASSFSNEAKVSSESAWYWLQHYNARSWKAKIDAALQFQNSTIREVRNLFEGADDPPEDVQETETVLAIPNRPALMAALISDINLTIDKPTFPSENYPLFLHNIGKGMPMSTKYALLIPMSIQLDMGEARVNLRDYPLDLLHIPGLRPGQSPRLPSWSLRTNFVIAEEYRDYKSSRKVNVELVPSSEMSDGTTSPPFLLDIWRSVSPVKTYSDPVIEINTNLPTSISWGMSYQPVIQDMMKIIEGFTKVEIDPSERVGFWDKIRLSFHSRIRVKWKEDGDVHLRLKGSRDPYVVTGFGCGFVMCWRKDVQWNIHTTDDPKEFMSVTSGEYVLAIPDYSHEARYLAEATAEDLETSSMSSDQKNAAQFKKVIMKLSGDVKWAAGLVFERNVNENERSTEFRPHYDVVLRNPNYINPSEREDYDAYRGFRSNHIHLSVAIIAPNSKNWNADSEQPTTSYNTVHLTPRFFTHFYSWWSLFSGVMSLPVRQGRLWPGITKTNKKFNRHLATIKYKLLLAPLFVAHIYKHKDPEDYVDDIVTATGIKVRLDSLKLDVHQRREQIKTPSKGRLKQPQASAIRIYRAELDLQAADFRAVSASIEGTGADELEKKRDDIISSFQQPVPPADLSRFTIPDHNLDWVDMDDFVELDWILPQESNPRTKILPLAFTPRFTYFRQTDQEEVSAGQTGYSSFGHEDTHECVMSDRNQPRRVQLALIQDRLATIEAKIQECTRSIGDLELQMAKDVDQNEQLRVQHREYLRQAASLARRRAFLTAGLHRLEKQLNQSKSTETYQSESTRADADSDSASDGKEADFDGLYSSPHDDLNSDFNNRFMIHSVQLKWNNSLRNIILRYIHQVSQRRGFVYYMSRRAVKFILDIVEEQSKNQATYSKLFRGSSRRPSDVHDDDDSVEDRIEQLLHDAKRFVSAEEQDPPEQKDPPTVRSDSSESISPEFTAQNSYHLRLIAPQIQLQSEKNHKSVILVAAKGMQLQVVSIMDKERVFDDVSGLVQRRFTLNMDGAQFFVATQKNLMTHLQFYAGNKYGNAPGSAWPPWLTLEAMFDFELNPFGFSRIIQKTSASLRYDKYNNLRLKYNDEVAKGQPDELGHPDGQETRMDSISVDFPQFRAICDSAEYYTLYIIVLDLLLYSEPLEKVRNERLERIMFTSDFSDLRGAPEMVYKLQSRIRQLEEIKEHFQIHAKYLDKRGWEDRLILEKDIARCEDELFFLMKAITTSQRKVEPTVTGATGLLRWNISASEIVWHLMKDESEPLVEFQLRNAEYDRTDNTDGSNHNQVSVERLYGLNLLPDAVYPQIIVPYLDQARRLEGPDDYMIKIKWHMLEAVAGIPVVDDFEVSLFPLKIQLEHELGQRVFEYMFPNVGSTAFENGGFSPFMIKNVKPLESLDSDDEESGQTSPSSLQHHSDTSGDDPAKGPSPLELRLQPTLSLSENPRLERRPTHLKAFAMTPIHKESGRQQARPASALVKKKSADSLRVLSRQATSLSANGVNDEKGKKFGLGIMGGKGKGKKGIDDFAQMMARASNYMTLAHVRVHDVVLCVSYKGKGEHNIEDLHDFVFRLPILEYRNKTWSNLDLALRLKKDVIKALISHAPAILGNKFSHHRPSKQQLRRYRELATSSQLLNNQDTGTSPPENGTSPSMASADSSSGYLSESQSHRSSPLARSNSLGSSMYSGKDQSGLFDSRSASEVDVDARWEQSRRIVNPPARPVTSGSAITRSDTARKIDWSEDGQLSATLAANYSLVGSNLPQNGLHTSHLFRHHPPSMDSLALTSQKFPSHSTLIIFHLYQDTPDGEKPEIRYGTNLAICVSDQVCLSRRGCVDGTWHPSRLNSRCRAPDWTELKWIKLYMGLNLKRKVLTLPFIDCIGTSAAFDARVAPITSHIDLGSSAMRAQLQFLSVFRWQVLANGDRFGHIVRGLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AWL7</accession>
    <accession>C8VCP0</accession>
    <name>Q5AWL7_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glycosyl hydrolase family 43 protein (AFU_orthologue AFUA_8G02510)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ANIA_07313</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF78636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_680582.1">
        <property type="nucleotide sequence ID" value="XM_675490.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AWL7"/>
    <dbReference type="STRING" id="227321.Q5AWL7"/>
    <dbReference type="CAZy" id="CBM35">
        <property type="family name" value="Carbohydrate-Binding Module Family 35"/>
    </dbReference>
    <dbReference type="CAZy" id="GH43">
        <property type="family name" value="Glycoside Hydrolase Family 43"/>
    </dbReference>
    <dbReference type="GeneID" id="2869848"/>
    <dbReference type="KEGG" id="ani:ANIA_07313"/>
    <dbReference type="eggNOG" id="ENOG502QW2A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016116_1_1_1"/>
    <dbReference type="InParanoid" id="Q5AWL7"/>
    <dbReference type="OMA" id="TEITYEW"/>
    <dbReference type="OrthoDB" id="9970295at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04081">
        <property type="entry name" value="CBM35_galactosidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18821">
        <property type="entry name" value="GH43_Pc3Gal43A-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005084">
        <property type="entry name" value="CBM6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22925">
        <property type="entry name" value="GLYCOSYL HYDROLASE 43 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22925:SF3">
        <property type="entry name" value="GLYCOSYL HYDROLASE FAMILY PROTEIN 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51175">
        <property type="entry name" value="CBM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010324822" evidence="6">
        <location>
            <begin position="20"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="CBM6" evidence="7">
        <location>
            <begin position="341"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBF78636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="475" mass="51717" checksum="246C6DE12129C93B" modified="2005-04-26" version="1">MHRRFKILYFALVAKYARAALDIIPGATWTADSTSKHMAPDSCMISCLPSPQYQPLTLHSEEDGTYYMIGEEKTDGALFQAVNCYSSTNLVEWTFVNQLLTVTEEEGADLGPNRIVERPKVIKNDNTGQYVMWMHIDSTDYADARVGIATGNSVCEDYVYRESFRPLGFQSRDIGLFKDEDGSAYLLSEDREYGTRIIRLTDDYLHVANVTFGWEYFAESPALIKRGETYFIFGSHLTGWSPNDNIYSTATSLSGPWTDWTEVAPVGSNTFSSQVNYVLPLGTDKAIYMGDRWVSSNLGASTYIWLPLQIDGTTATASLTWYDSWSVDLASGTWNAEEDETVYEGEDGALSGGARLIDCSRCSGSTAAGYIGGAGDGENDGAVTLQVDYATQSTDSARITLNIHYLNGDTDPRYAAVSVNGGEAQTIAFLSTNQLSGSGSSAVHVDLVQGVNTVQISGVEGGGWGPDIDQVAVPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AWP2</accession>
    <accession>C8VCR8</accession>
    <name>Q5AWP2_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphoribosyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_07288</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF78690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_680557.1">
        <property type="nucleotide sequence ID" value="XM_675465.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AWP2"/>
    <dbReference type="STRING" id="227321.Q5AWP2"/>
    <dbReference type="GeneID" id="2869763"/>
    <dbReference type="KEGG" id="ani:ANIA_07288"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN7288"/>
    <dbReference type="eggNOG" id="ENOG502SH5I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012235_1_0_1"/>
    <dbReference type="InParanoid" id="Q5AWP2"/>
    <dbReference type="OMA" id="GHFMFWP"/>
    <dbReference type="OrthoDB" id="5416609at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13207">
        <property type="entry name" value="AAA_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14681">
        <property type="entry name" value="UPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="1">
        <location>
            <begin position="471"/>
            <end position="667"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF78690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="671" mass="74602" checksum="0B195FEE11D74040" modified="2005-04-26" version="1">MEPRTTSEPVNSSVPAHAAALAAPRVIGLYGLPGCGKSYIMDQLKQELGETDFEYFEGSKEISKVTPGGLDEFKMQDKYKQDHWRKLAIDAIKSTCAQTGKTGIVTGHYMFWEGGKKEEASRVCSQADLATYTHILYVNAPLEVTAKQRAEDTKRARSNLSSEHLRRWQETEIQEIHDLCRENNILFATIYPNLKSKLASLIRDFQCHDENHNRLVAEHIFDKCISPSYDELQTVLFFDADKTLAAVDTGTRFWKIHETKGGKKDPLSALFRGPLGYSYTAFRQAMLLYEESTNDDEFEAICEEIASHTRPLSGNVLASAPGRKLPPRFFCHCDLRTTTLKVVGGGRIKDGFVVTPSVKECLITRAKSAHTVYTWAFGDSPLDLPMMRAAHKPVVVVGEQQSRSKSMEHKLLTEIRDNGLQARQVLLPVNTSPPLLDTAKLPVANLTEKSFLDEIFQPLGRPGGVRLHHATDSHATKLLSTPMRDDSIRGPSLQEAHENAGRYLATRYLVELIGTEVLAIRHPQGNFVAGYRLLDEEQTLIVPLMRGGQSMASGIFKVFPKARLHDAKEPTDVKEEHLKGIVNVILVDSVINSGESMAQFVQRIREVDGAVRIIIVAGVIQDQAVKGCSQLRAVARSTELTVVALRLSANKYTGKGTTDTGNRLFNTTYLD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2010-06-15" modified="2026-01-28" version="100" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AX28</accession>
    <accession>C8VD73</accession>
    <accession>Q1HFR9</accession>
    <name>AGALD_EMENI</name>
    <protein>
        <recommendedName>
            <fullName>Alpha-galactosidase D</fullName>
            <ecNumber>3.2.1.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Melibiase D</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">aglD</name>
        <name type="ORF">AN7152</name>
    </gene>
    <organism>
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="11417" last="11422">
            <title>Development and application of a suite of polysaccharide-degrading enzymes for analyzing plant cell walls.</title>
            <authorList>
                <person name="Bauer S."/>
                <person name="Vasu P."/>
                <person name="Persson S."/>
                <person name="Mort A.J."/>
                <person name="Somerville C.R."/>
            </authorList>
            <dbReference type="PubMed" id="16844780"/>
            <dbReference type="DOI" id="10.1073/pnas.0604632103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA]</scope>
        <scope>FUNCTION</scope>
        <scope>BIOPHYSICOCHEMICAL PROPERTIES</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Hydrolyzes a variety of simple alpha-D-galactoside as well as more complex molecules such as oligosaccharides and polysaccharides. Active on paranitrophenyl-alpha-galactoside but not on raffinose, locust bean gum and gum guar.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.</text>
            <dbReference type="EC" id="3.2.1.22"/>
        </reaction>
    </comment>
    <comment type="biophysicochemical properties">
        <phDependence>
            <text evidence="3">Optimum pH is 5.0.</text>
        </phDependence>
        <temperatureDependence>
            <text evidence="3">Optimum temperature is 52 degrees Celsius.</text>
        </temperatureDependence>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyl hydrolase 27 family.</text>
    </comment>
    <comment type="sequence caution" evidence="4">
        <conflict type="erroneous gene model prediction">
            <sequence resource="EMBL-CDS" id="CBF78972" version="1"/>
        </conflict>
    </comment>
    <comment type="sequence caution" evidence="4">
        <conflict type="erroneous gene model prediction">
            <sequence resource="EMBL-CDS" id="EAA61404" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EC" id="3.2.1.22"/>
    <dbReference type="EMBL" id="DQ490505">
        <property type="protein sequence ID" value="ABF50881.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AACD01000122">
        <property type="protein sequence ID" value="EAA61404.1"/>
        <property type="status" value="ALT_SEQ"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF78972.1"/>
        <property type="status" value="ALT_SEQ"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_664756.1">
        <property type="nucleotide sequence ID" value="XM_659664.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AX28"/>
    <dbReference type="SMR" id="Q5AX28"/>
    <dbReference type="STRING" id="227321.Q5AX28"/>
    <dbReference type="CAZy" id="CBM35">
        <property type="family name" value="Carbohydrate-Binding Module Family 35"/>
    </dbReference>
    <dbReference type="CAZy" id="GH27">
        <property type="family name" value="Glycoside Hydrolase Family 27"/>
    </dbReference>
    <dbReference type="GlyCosmos" id="Q5AX28">
        <property type="glycosylation" value="9 sites, No reported glycans"/>
    </dbReference>
    <dbReference type="KEGG" id="ani:ANIA_07152"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN7152"/>
    <dbReference type="eggNOG" id="KOG2366">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013093_3_0_1"/>
    <dbReference type="InParanoid" id="Q5AX28"/>
    <dbReference type="OrthoDB" id="5795902at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004557">
        <property type="term" value="F:alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046355">
        <property type="term" value="P:mannan catabolic process"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="CDD" id="cd04081">
        <property type="entry name" value="CBM35_galactosidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14792">
        <property type="entry name" value="GH27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1180:FF:000008">
        <property type="entry name" value="Alpha-galactosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000197">
        <property type="entry name" value="Alpha-galactosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002241">
        <property type="entry name" value="Glyco_hydro_27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041233">
        <property type="entry name" value="Melibiase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452:SF75">
        <property type="entry name" value="ALPHA-GALACTOSIDASE MEL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452">
        <property type="entry name" value="ALPHA-GALACTOSIDASE/ALPHA-N-ACETYLGALACTOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16499">
        <property type="entry name" value="Melibiase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17801">
        <property type="entry name" value="Melibiase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00740">
        <property type="entry name" value="GLHYDRLASE27"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword id="KW-1015">Disulfide bond</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0326">Glycosidase</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0624">Polysaccharide degradation</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000395075" description="Alpha-galactosidase D">
        <location>
            <begin position="21"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="223"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="201"/>
            <end position="205"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="48"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="438"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="450"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="484"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="551"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="583"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="125"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="16844780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="659" mass="71482" checksum="F7D5BC5D10F6ECAB" modified="2010-06-15" version="2" precursor="true">MRALVPMVVAATALASPAPALKPRLDDGLARTPQMGWNTYNQYNCFPNESIVHENAQALVDTGLADLGYRYVTIDCGWGVEDRLPNGTITWNPELFPQGFPAMGQYLHDLGLLFGVYGDSGILLCGSPPNITGSLYYEDIDARTFAEWGADSLKYDNCYSDAATNYPNVNYAPSTSPHPRFANMSRYIQAQDRDILFQVCEWGIDFPALWAPEIGHSWRIGNDIIPHWRSIFRTLNQAVPQTDFAGPGQWPDLDMLLVGLDGVLTVPEEQTHFSLWSILKSPLTIGAAIPGMRAESLEILSNADVIAFNQDALGVSAALRRRWSDEGYEVWSGPLEGGRTIAAVINWRDEDREITLDLPDIGLQYAETLQNVWADETVNGVKTSYSSVVEAHGVMLVQLAETVEEGVYPADVFAATNRDVTTFSDVYAITSSPNFVLNITLTEVTAAATNITIITDSSRRPISTSIPAGSSSISTSVSLIAGSNNTITIRNAPPLSSITLSPPEPTYYTGAQDFTLTSPAGAYTCPDAYCLPAGSKIVDLSTESAATAHINSSTSGSKYLEIDYINNEVAFDSSWGWGANSRNLTIKVNDNNPVRLEVPLSGRHSELFGPGLGWWDSGRLGVLTDGWIKGTNELVLSNEGGEGGFTKYAPDVVGIAVYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AX94</accession>
    <accession>C8VDF0</accession>
    <name>Q5AX94_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F-box domain protein (AFU_orthologue AFUA_3G01810)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_07086</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF79112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_664690.1">
        <property type="nucleotide sequence ID" value="XM_659598.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AX94"/>
    <dbReference type="GeneID" id="2870059"/>
    <dbReference type="KEGG" id="ani:ANIA_07086"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN7086"/>
    <dbReference type="eggNOG" id="ENOG502SIWQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043307_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AX94"/>
    <dbReference type="OMA" id="LMALICH"/>
    <dbReference type="OrthoDB" id="3886018at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF79112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="471" mass="52867" checksum="4786065658C39326" modified="2005-04-26" version="1">MACLEYLPNEIIETIVSLLELTDIRNLRLTSRGLALRSSGHHFKSHFRRKHVDITESTLRDFVQATKPGRLGRLVQYLVLVGSHLPTEKQGLEAEDEAKTRQDLEVLAQRRTDYRVMRSSGTDVRLLSEAFGNLMAQDGGNNTAGGPRLRTLSLKVVVYHTDAEQRLPPKTGGWVPIWQVATETFHTALRALAISAMPVAKLDIYTQQSRSSLACSELSAVDHESSGLVASLASVKSLSVSFSDRIINGRRENLGITGGSADEVDRDAPVIDDFRDNEDVEAEACDESTFIGLVRLVQLCSGLKELELHHYKLGNHTVFVDLHREQFLQRIVAMTTLTTLKRCALRGLTVREVDLLAFIKETAPAIVELTLQNVSLVSGTFRAIFDHCTSEASCLTRLFFDDLFEQKLLYFVGEPGQSKLRSFNYQCSETLDRTGPEVRRPISYFIPLGRPKGSPALWQWRMRRRREFGPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AYJ7</accession>
    <accession>C8V1B8</accession>
    <name>Q5AYJ7_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_06633</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF71138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_664237.1">
        <property type="nucleotide sequence ID" value="XM_659145.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AYJ7"/>
    <dbReference type="GeneID" id="2870374"/>
    <dbReference type="KEGG" id="ani:ANIA_06633"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN6633"/>
    <dbReference type="eggNOG" id="ENOG502SEQP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_186255_1_1_1"/>
    <dbReference type="InParanoid" id="Q5AYJ7"/>
    <dbReference type="OMA" id="CGNRGRM"/>
    <dbReference type="OrthoDB" id="5230947at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF71138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
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</entry>
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        <name evidence="4" type="ORF">ANIA_06590</name>
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            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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            <taxon>Aspergillus subgen. Nidulantes</taxon>
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    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
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            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF71051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_664194.1">
        <property type="nucleotide sequence ID" value="XM_659102.1"/>
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    <dbReference type="STRING" id="227321.Q5AYP0"/>
    <dbReference type="GeneID" id="2870656"/>
    <dbReference type="KEGG" id="ani:ANIA_06590"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN6590"/>
    <dbReference type="eggNOG" id="KOG3687">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003828_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AYP0"/>
    <dbReference type="OMA" id="ATRFLMN"/>
    <dbReference type="OrthoDB" id="19311at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
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    <dbReference type="GO" id="GO:0033596">
        <property type="term" value="C:TSC1-TSC2 complex"/>
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    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032007">
        <property type="term" value="P:negative regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051056">
        <property type="term" value="P:regulation of small GTPase mediated signal transduction"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="ARM-type_fold"/>
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        <property type="entry name" value="Rap/Ran-GAP_sf"/>
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        <property type="entry name" value="Rap/Ran_GAP_dom"/>
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        <property type="entry name" value="Tuberin-type_domain"/>
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        <property type="entry name" value="Tuberin/Ral-act_asu"/>
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        <property type="entry name" value="Tuberin_N"/>
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        <property type="entry name" value="TUBERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10063:SF0">
        <property type="entry name" value="TUBERIN"/>
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        <property type="entry name" value="DUF3384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02145">
        <property type="entry name" value="Rap_GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03542">
        <property type="entry name" value="Tuberin"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="RAPGAP"/>
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        <location>
            <begin position="1273"/>
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    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="816"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="776"/>
            <end position="787"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
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        <source>
            <dbReference type="EMBL" id="CBF71051.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="1570" mass="173886" checksum="DFB2DD775055995B" modified="2005-04-26" version="1">MPSDDVSFPPRSKYSTSSFADVFRSLSASRAKSFPATPLSDSSNSVHDDTDGHTSFWNASGFDSMHRGSVVSSSSDASGGRDFETSVKLLAQKQNLGHACDEAEQVAKALQWYTPEQALGLWEAGSHLLHHEGSPDARRSGSLLLVSLSARQDLSPAARRTVFDSIASESEPDVIPARAQALISLSDHGRRLEFATSSLLPLISSFIVPLYEIISSARAKARKAKVGKANGLAYEDSVLDDLLQFAVDLITLQRKQPESDEVRELLDQIFIICRKTSVAADIKHSLAVFDAVILYGNVPDGSFTPMLELLCSIHASVRSLSGPTSRAVRNLAKSRRKHEMVATLHSFLLESNGENCQNLNVLRGAVYVFADLIRAHGQEGIAQLQFEPLMNSLQVVLQKNDGRLEADILELCLNTLEGEFAQVTLTQDWTGFVSILNFCSRRVVEEPETSATKPLSPDSPQSRGSVIDDVKPNILANIVQIASAVGSLWDSLNGQQRLEITNFLSNVCQHIEPTQAELILNTMRTEKLCDPQTSGWVQCCQQVINYFVRDRSKPTEVRITALEILKEAFHGYESMVLFHKERLLDLMLEDFSNEDSILFLESLVSFLVDNIVPSCDDTAFKSLIDIISSPMAKDSNPGESEPVQVSPPEGRSLSFALEASLANVCALGLVRTFLRSLNLSAAKAIKVYEALLKIAESSDRPLDSRLTALKMLFRLRCDSSGSIIVISVPEDDFRMSISGRNLEVGSLTNDLEDATGDYIADNDPGLSSTQKRHPTRATSSSALSRSTGRITNYNQRVPKLSHPVWAYAAPQVLPEEPPDGSSPFLYARATPNTSPQLDSEPAQRIALKANVWLETIIILLQRETNWDIYSYVLTHLAPQLQNKDLFDNAVPQIKLLRSILCDQIKNDSFREPPIYTGVKKSDVAGYIFDSLCVLISYHEHFAKSEEDELVRSFMMGIIGSWGGTSRGCIHALSVCCHEIPLSVTKALNGILDKISKLITLSNLAVHILEFLALLARLPEVYINLREEEIRTVFGICIRLLQTSREHRLKATEAPNRNPQGAARTGSVVGETAALPGNEMSEPSTQDAMSTYIYTSTHHVMIFWFLSLKLQDRAKHINWITSRLIFTDEHGKETLEEQSQVFLDLMQRVAFSDLGETIPYATFPPSPEDGPVIKRSWIVGMSIVTLETAGVSGLTQITKRQASGTTYAMYQQRTAPILPHQIPISHDAHLHSDSMHTNVLPSHIMLQLTATAFPTPTTIQPIPLPDDDITRRALSTFDRNDIVDGHKIGVIYIDDGQTTEAEILSNTVGSPDYEYFLSQLGTKVSLKEARFNTQGLHAETDGEFTYAWRDRVTEIVYHVATMMPTNFDSDPSCILKKSHIGNDFVNIIFNRSNTPFNFNTIPSQFNFFNIVVSPVSRLTQGDKMASAAASNPENMFYCVKVMSKPGFPEISPAASPKIISGKNLAPFVRILALNASVFSLVWNSQGEHISSWRNRLREIKRLRERVLGSQSQNADTLDATYPTQRRNTKANIFSEEVPVRTSSGKSEISTDWNATADSNILQNLDFSRWAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AYP4</accession>
    <accession>C8V121</accession>
    <name>Q5AYP4_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">RNA binding protein, putative (AFU_orthologue AFUA_6G04320)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ANIA_06586</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CWC21 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF71043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_664190.1">
        <property type="nucleotide sequence ID" value="XM_659098.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AYP4"/>
    <dbReference type="STRING" id="227321.Q5AYP4"/>
    <dbReference type="GeneID" id="2870651"/>
    <dbReference type="KEGG" id="ani:ANIA_06586"/>
    <dbReference type="eggNOG" id="KOG1869">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067891_2_0_1"/>
    <dbReference type="InParanoid" id="Q5AYP4"/>
    <dbReference type="OrthoDB" id="10267305at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21372">
        <property type="entry name" value="cwf21_CWC21-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051372">
        <property type="entry name" value="CWC21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013170">
        <property type="entry name" value="mRNA_splic_Cwf21_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36562">
        <property type="entry name" value="SERINE/ARGININE REPETITIVE MATRIX 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36562:SF5">
        <property type="entry name" value="SERINE_ARGININE REPETITIVE MATRIX 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08312">
        <property type="entry name" value="cwf21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01115">
        <property type="entry name" value="cwf21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="CWF21" evidence="8">
        <location>
            <begin position="62"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="80"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="168"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="40"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="80"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="174"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="188"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBF71043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="313" mass="34413" checksum="E26C2FC35B4562EC" modified="2005-04-26" version="1">MSSNVGLSTPRGSGTSGYVQKNHAFLRPRNTGAGAPYPSPSSSSKDGSESSFKQRQPDRAILEHEMKREIEVKVLEERERLEDINERVEEGKGREGEKVRSEEEIEKICDELRERLTREMEDRKNGNGRNDGRNRDGKGKRGFKAYQVHELAEAKIKESERLRRALGIRDLDEQGGGGGGGGSSSARAEVERRREKERERERERPSFTSFLCMTFLAGNGQPVLPTSPTNDGITKQARLSGTPPNDSIFPIGFPYSMSGVPCASAESCNPLGVTSGYILIFGTSPATTEGTDCSFSLMSDVLMGASRDRKSVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="119" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AZ26</accession>
    <accession>C8V0C9</accession>
    <name>Q5AZ26_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ANIA_06454</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF69440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_664058.1">
        <property type="nucleotide sequence ID" value="XM_658966.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AZ26"/>
    <dbReference type="STRING" id="227321.Q5AZ26"/>
    <dbReference type="GeneID" id="2871351"/>
    <dbReference type="KEGG" id="ani:ANIA_06454"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_361314_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AZ26"/>
    <dbReference type="OMA" id="GINENMD"/>
    <dbReference type="OrthoDB" id="508119at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF60">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="423"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="448"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="490"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="553"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="587"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="620"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="662"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="697"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="727"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="309"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="126"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="21"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="71"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="82"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="143"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="187"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBF69440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="774" mass="86947" checksum="5B4C17CEDE2FEFD8" modified="2005-04-26" version="1">MSPRLDYNEGYDSEDEEIPRYVHHSRGKSHRSVRTSGRSRTLDYDGDDEASDHAAPSGIDRDARACPTSRRYTDDCLETHKFRGARSSRSRGRTDDNKVLYYTKYRSPAKDLPIERDPEGINLFKVRQHTRPSDAHVPSGYREPYEVKVDEYEDDHPRTCTSRRDSRQPKVYKVRVDEYEDNLPARSHTDFRESPRSERCSSRYTEDSKPGELPPRSGPCRSSRPSPVDEDVEYEIREPRGHRSSRHSTDVDFQPVEQHPRFGQRGLSRPSRVDEEVDYEIREPRGNRVSHAAHGDSPCQDQSSRHIGIQLWTGVPVLSRQLTHAISTPVNMFRTVEDRPTPKEVYNWRLYTEATIIATGTLLFGYDSAFVGTTIARQSFVDAFNIVESEAADISSNITSTFQAGAFFGAIFCFLPEADAGRALTGIACGAITATVPSYIAELSIVSIRGFLTGFFEVAYQIGSLVGFWINYGINENMDNSSAASWRVPMAVQIIPAGVLFIGGFSSMREDIEMNRTRLLEEARIAEKYGQGWLAYIRGALFELSRHGMWNRVLLVLCAFALQNMSGAAAINYYSPILFASLGITDVALYTGIYGLVKAVASIIFYGILIDMWGRRRPTIVSSLACPLCLWFVGAYVKVGHPADIIDAGGELSPSTEAGGRAATAMIMIYSVFWSFGLNGIPWIVSAEIFPGALRNLTGTWAALVQWLIQFVITKALPYIFNSLGYGTWFFFASWMLLAIIWSFFFLPETKGKTLDEMHTIFLSKDGTHTITLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="131" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AZE9</accession>
    <accession>C8V110</accession>
    <name>Q5AZE9_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">CCCH zinc finger and RRM domain protein (AFU_orthologue AFUA_2G13540)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ANIA_06331</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">May be involved in the turnover of nuclear polyadenylated (pA+) RNA.</text>
    </comment>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF69686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_663935.1">
        <property type="nucleotide sequence ID" value="XM_658843.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AZE9"/>
    <dbReference type="STRING" id="227321.Q5AZE9"/>
    <dbReference type="GeneID" id="2871230"/>
    <dbReference type="KEGG" id="ani:ANIA_06331"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN6331"/>
    <dbReference type="eggNOG" id="KOG2135">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017928_1_0_1"/>
    <dbReference type="InParanoid" id="Q5AZE9"/>
    <dbReference type="OMA" id="ITYDSHA"/>
    <dbReference type="OrthoDB" id="443401at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12257">
        <property type="entry name" value="RRM1_RBM26_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1390.10:FF:000007">
        <property type="entry name" value="CCCH zinc finger and RRM domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000647">
        <property type="entry name" value="CCCH zinc finger and RRM domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1390.10">
        <property type="entry name" value="PWI domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002483">
        <property type="entry name" value="PWI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036483">
        <property type="entry name" value="PWI_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
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</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AZH6</accession>
    <accession>C8V188</accession>
    <name>Q5AZH6_EMENI</name>
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        <submittedName>
            <fullName evidence="6">Stress activated MAP kinase interacting protein, putative (AFU_orthologue AFUA_2G12210)</fullName>
        </submittedName>
    </protein>
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        <name evidence="6" type="ORF">ANIA_06304</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
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            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
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        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
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        <text evidence="1">Belongs to the SIN1 family.</text>
    </comment>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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            <begin position="575"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="689"/>
            <end position="698"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBF69744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="843" mass="92476" checksum="A40AEB50E0F917E7" modified="2005-04-26" version="1">MSLLHNEDFTIWQLRTSYLSTIKDGIGDRLINVNHSVLNTPGFRAAGWPAASANHPSQLAASIKRTYSPPIPTATAVSSEYYQLGARDLNDSQRSGFGQDGEDDEGGMVTGKSTIDGIGRRNPLRNEKRAHRKERQQREQQKARDVEEDDSSDLSDESDDDGEPLQRASEEIKFPKVPVRIRAGSSPIRATDRQERPQVMVTHPSHTSMNSHYRTGSLGTAPSVSERPRRDTTTTTTSSDMSSDHEIDMSAPGYRRRQIHFSGHDQVIDLGKASSDGLEQLDEQEEDSDAGSVESALSSEFDATAGSASLLGAVGITGGLNSSSPIALMHKLPHGPSSQTASPRKPKPPAPELQDLPPPRPISTVQPVSLLSTALNARAKAPANPVERFAVLSGKGLTDALNIRLYVPFSSDPEEPLDLPLARESKLADQPAPVTVAEAIGLALWRYSEERRQPPIERDKLNVNRWTLRMVEDGEVEYDFPPLGRASAISDFTSNNNSRAGGMRGRSRGKQYDEFALVEASDMEFEENERLYPMYNVSAPAEEARDPAPAAAAAPAGQPVPQTKTARPNPILGQPFSSALNDNTLTPADRPAVPVSHATPRLGVSKTLKIRYTNLESSTQTTTLNTSTDSYIAEILDSVCKRWGLDKGNYLLKVMGSNTIAPLDRTVEALGNITDLDLVRRRFGPQVLTGSPVSSSPNAPLLVDSPAVPTKKGKKSGQRMLHPLTQQQDLIGGYYRRYFVLRKQSMGFTTSLHRVLTFDNDYMHIMPADTGKNGSDTKTRSISFNDVVGCKVSRRHPKNFRVVVLRGNDATEQKRYDFEARNSFEAEEIVGEIKKNMAQYRTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AZL8</accession>
    <accession>C8V1I0</accession>
    <name>Q5AZL8_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Gag1-like clamp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_06262</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF69829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_663866.1">
        <property type="nucleotide sequence ID" value="XM_658774.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AZL8"/>
    <dbReference type="STRING" id="227321.Q5AZL8"/>
    <dbReference type="GeneID" id="2871166"/>
    <dbReference type="KEGG" id="ani:ANIA_06262"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN6262"/>
    <dbReference type="eggNOG" id="ENOG502SRCS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036307_2_0_1"/>
    <dbReference type="InParanoid" id="Q5AZL8"/>
    <dbReference type="OMA" id="WKSDGQW"/>
    <dbReference type="OrthoDB" id="5422958at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053274">
        <property type="entry name" value="Fluconazole_resistance"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025124">
        <property type="entry name" value="Gag1-like_clamp"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28065:SF1">
        <property type="entry name" value="DUF4050 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28065">
        <property type="entry name" value="FREQUENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13259">
        <property type="entry name" value="clamp_Gag1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gag1-like clamp" evidence="2">
        <location>
            <begin position="74"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="361"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="208"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="251"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="431"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF69829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="451" mass="48728" checksum="BF7D628F68540365" modified="2005-04-26" version="1">MSSESRDEAIREAKRYVRDVVQNDWSFEFSAKPGAPPPKYPANPEPTEVLEWRLREYDSSGSELEPQFSPIGSPERVDVGDAFDASSPQSAGSQQRRRKRRRQMEEEMSWNEGLRTWLERRDAWSGALSREQVRMWEQKHRSMSTKDAESGDKGGNAATALDTDAQSIPASTTSRPFAIPATGPATGESPNLASRTEALNIADNQTTPLQAQQAQDQSSDIQPPIPNDNAGKLEITTDAIPEIPVLPQSLTSATAVPTAEPPSTTTTTSSTPSTQDHFYDPLIPVVPSMIATSNPIRASITPAMYPSIYSKVVIQGLTPTVPINLADMTKAMVQGWKADGQWPPKPQNLVLANDAIVRPSNASATKHPDTPAIPASASGDKNRPSSPESKRKSGIASTVRKVLHFSGFQHHPFHRRGSSSQNISHQEDPAEAGVGAAEGSSVGANVEQGDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B0A4</accession>
    <accession>C8V319</accession>
    <name>Q5B0A4_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Proline dehydrogenase</fullName>
            <ecNumber evidence="2 5">1.5.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ANIA_06026</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Converts proline to delta-1-pyrroline-5-carboxylate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-proline + a quinone = (S)-1-pyrroline-5-carboxylate + a quinol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23784"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17388"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.5.5.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the proline oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.5.2" evidence="2 5"/>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF70334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_663630.1">
        <property type="nucleotide sequence ID" value="XM_658538.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B0A4"/>
    <dbReference type="STRING" id="227321.Q5B0A4"/>
    <dbReference type="GeneID" id="2871102"/>
    <dbReference type="KEGG" id="ani:ANIA_06026"/>
    <dbReference type="eggNOG" id="KOG0186">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018202_0_1_1"/>
    <dbReference type="InParanoid" id="Q5B0A4"/>
    <dbReference type="OMA" id="AESQHYQ"/>
    <dbReference type="OrthoDB" id="5464at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004657">
        <property type="term" value="F:proline dehydrogenase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010133">
        <property type="term" value="P:L-proline catabolic process to L-glutamate"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.220">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002872">
        <property type="entry name" value="Proline_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015659">
        <property type="entry name" value="Proline_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13914:SF0">
        <property type="entry name" value="PROLINE DEHYDROGENASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13914">
        <property type="entry name" value="PROLINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01619">
        <property type="entry name" value="Pro_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="FAD-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 5" id="KW-0642">Proline metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proline dehydrogenase" evidence="6">
        <location>
            <begin position="192"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBF70334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="378" mass="41494" checksum="0D07E2EE0C48C820" modified="2005-04-26" version="1">MAIDGAYPPATLPAGDTKTESESAAITAAAHPLSALPTPVLLRSLLIATISSKPSLLIPSLSALSFLCKPRAGPLLNVDRNPILHFILKATFYRQFCAGETPDEVRSTIRQLAGMGFQGTIMTYAKESVFDAKTKMQTGLGVSTKMSGKQEVTEPTLARGEAFCPQIEAWRKETVETIELLGANDYLALKLAYLKSTPATIARHLQAASDVGFTLGLKLVRGAYIFSDERSLIHETKADTDAAYNGIAQGVLCRQLGAFGTEKPFPSVELFLASHNKESVMKAHALRLQRLKEGLPTVPVGFGQLHGISDEVSFRLLTLKNERNEPMVYKCSTWGRLSECLAYLVRRAVENRDAVGRTEDEYRALKREMARRSWYSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="110" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B0F1</accession>
    <accession>C8V3B5</accession>
    <name>Q5B0F1_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">40S ribosomal protein S17, putative (AFU_orthologue AFUA_2G10300)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ANIA_05979</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS17 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF70428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_663583.1">
        <property type="nucleotide sequence ID" value="XM_658491.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B0F1"/>
    <dbReference type="FunCoup" id="Q5B0F1">
        <property type="interactions" value="1033"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5B0F1"/>
    <dbReference type="GeneID" id="2870887"/>
    <dbReference type="KEGG" id="ani:ANIA_05979"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN5979"/>
    <dbReference type="eggNOG" id="KOG0187">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112958_0_1_1"/>
    <dbReference type="InParanoid" id="Q5B0F1"/>
    <dbReference type="OMA" id="MKRIQQG"/>
    <dbReference type="OrthoDB" id="1727351at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.60.20:FF:000001">
        <property type="entry name" value="40S ribosomal protein S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.60.20">
        <property type="entry name" value="Ribosomal protein S17e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00511">
        <property type="entry name" value="Ribosomal_eS17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001210">
        <property type="entry name" value="Ribosomal_eS17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018273">
        <property type="entry name" value="Ribosomal_eS17_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036401">
        <property type="entry name" value="Ribosomal_eS17_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002242">
        <property type="entry name" value="PRK01151.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10732">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10732:SF0">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00833">
        <property type="entry name" value="Ribosomal_S17e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116820">
        <property type="entry name" value="Rps17e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00712">
        <property type="entry name" value="RIBOSOMAL_S17E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBF70428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="139" mass="16149" checksum="0FEE83863423AAD1" modified="2005-04-26" version="1">MGRVRTKTVKRSAKVVIERYYPKLTLDFETNKRVCDEIAIIPSKRLRNKIAGYTTHLMKRIQRGPVRGISFKLQEEERERKDQYVPEISALDVSQTESGQLDVDSDTKDLLKSLGFDNLKVNVVAVTQQQPERPRRFRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B0I9</accession>
    <accession>C8V3H8</accession>
    <name>Q5B0I9_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ANIA_05941</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF70520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_663545.1">
        <property type="nucleotide sequence ID" value="XM_658453.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B0I9"/>
    <dbReference type="GeneID" id="2870828"/>
    <dbReference type="KEGG" id="ani:ANIA_05941"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN5941"/>
    <dbReference type="HOGENOM" id="CLU_577496_0_0_1"/>
    <dbReference type="InParanoid" id="Q5B0I9"/>
    <dbReference type="OMA" id="WVCARAV"/>
    <dbReference type="OrthoDB" id="6365676at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF70520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="473" mass="53769" checksum="81926F8A1D61DF14" modified="2005-04-26" version="1">MQLPPELILLVIEALIPFKSRILPPGHIVTRTLLSLSLTCKLTYPLARELLFTHCLYLNSGKRIENVLNQSQLYRFGRYGPAGVDKGTRARSLFLAFPSPVTISLNSTDRQIDSLLSLFSTNVRCLIIDLPLRHLIFNDTENRRAQNVVYGAILRLEAVEEFCYLRDGLGTAPYRHTWLNRLDISAWSLGVTLMWPRLRRLALCNPAFDHLLVETLRQSSNLTHLAFTCPSKMESLYTDRAVQSLDFAKTFSHLQRVLILQGDGPLEITHPWDFWESRMVTQHVDRGNWEQSFLGKLMVTMQTAARSTSVLQFQPELVYINEPKTGPFDAEDYATFQEWTGARALDGTLWDYPGLIYDANVHGRIAAALFADAQDENSRSAFAGLTVPGIYALFKGHIAMCGANPIGNLTQLTKTRTYTQSCRCISLSRNRLEGDSKILPNQREFWLWRTHQVRFRDGGISRKLLEFGYNIGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="130" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B0U8</accession>
    <accession>C8V032</accession>
    <name>Q5B0U8_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ras small monomeric GTPase RasB (AFU_orthologue AFUA_2G07770)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ANIA_05832</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Ras family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF70756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_663436.1">
        <property type="nucleotide sequence ID" value="XM_658344.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B0U8"/>
    <dbReference type="STRING" id="227321.Q5B0U8"/>
    <dbReference type="GeneID" id="2870713"/>
    <dbReference type="KEGG" id="ani:ANIA_05832"/>
    <dbReference type="eggNOG" id="KOG0395">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041217_9_8_1"/>
    <dbReference type="InParanoid" id="Q5B0U8"/>
    <dbReference type="OMA" id="MWGCPFV"/>
    <dbReference type="OrthoDB" id="5976022at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019003">
        <property type="term" value="F:GDP binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000654">
        <property type="entry name" value="Small g-protein ras2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="180"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBF70756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="225" mass="24845" checksum="0B68841C27C17853" modified="2005-04-26" version="1">MAGKMTLYKLVVLGDGGVGKTALTIQLCLNHFVETYDPTIEDSYRKQVVIDQQSCMLEVLDTAGQEEYTALRDQWIRDGEGFVLVYSITSRASFSRITKFYNQIKMVKESANSSSPSGASYLGSPMSSPSGPPLPVPVMLVGNKSDKAVERAVSAQEGQALAKDLGCEFVEASAKNCINRMQQQRPQDTRRTTGLGQMRDSGPEYPRTFRPDRPRHRGGIKCQIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B256</accession>
    <accession>C8VGQ0</accession>
    <name>Q5B256_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_05374</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF82014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_662978.1">
        <property type="nucleotide sequence ID" value="XM_657886.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B256"/>
    <dbReference type="GeneID" id="2871666"/>
    <dbReference type="KEGG" id="ani:ANIA_05374"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN5374"/>
    <dbReference type="HOGENOM" id="CLU_698352_0_0_1"/>
    <dbReference type="InParanoid" id="Q5B256"/>
    <dbReference type="OrthoDB" id="10666163at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="57"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="254"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="71"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF82014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="395" mass="44979" checksum="A33ED9D70A69FF1E" modified="2005-04-26" version="1">MAQTLCQFVNHVDALQHTIAQLNKQFLPPSPTFTHHSPEDQESTDQALAVVKHTADGQYDPAGNEHIPTGPNRSSSLNHDGNQDHEDGERLACLYAEYGVDNSWHLPTNRVRTISYPLPEPQPLNGPEPTTGMALYRSLPLPTSPRAQTPAAVKAEQSKATVQGKPKGRSHSVPIMSLRSLYWYEMLDYESEPNPGSITWEESAEEDVCIEGTGPFWSEKEVGIEGYIDGRCASIVSSIDREQRSMVWETELRIFQQAHELERAKKEVARLKERIKDLQVAGRIYRDKLTMATQGIEEVKEQWRRDKSDLMDARECITWLEMQWGKDHAELLIARDYITELEKTGVQCDCWRKRKWELDVPGSTKKAKANGGNARRRSYDDFWAAQESRRSVLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B2P0</accession>
    <accession>C8VF64</accession>
    <name>Q5B2P0_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_05190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF81048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_662794.1">
        <property type="nucleotide sequence ID" value="XM_657702.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B2P0"/>
    <dbReference type="STRING" id="227321.Q5B2P0"/>
    <dbReference type="GeneID" id="2871482"/>
    <dbReference type="KEGG" id="ani:ANIA_05190"/>
    <dbReference type="eggNOG" id="ENOG502SIXT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_385428_0_0_1"/>
    <dbReference type="InParanoid" id="Q5B2P0"/>
    <dbReference type="OMA" id="FHEWIAN"/>
    <dbReference type="OrthoDB" id="4501801at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="67"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF81048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="717" mass="80114" checksum="2218A1BADB46E550" modified="2005-04-26" version="1">MEDPWIIHIPTDSPDDPDWTMDSNSITDSETFPGTDAETGDEMYSDVLTDTESDPSEIDSEAESGIVSPTDVEVSSDTSSESMHSDMDTETNDKAGFGGVSVAGRGIVSITGSVRSDENIELGLVRERGMTSLSDDERESVMALIDAAMTEMGVNIDPEIGFGIGNEETLRIGSVGSVSFGFEAGSVASVYNAKSASEVGSGVGSEAEFETCVVDSGFYSEIDIERDDNTDAGASCEASCETGVLDSGFESERDVKENDDIGAEMDLGYNTDAEMIVIKSNIGESTDSGSDSCSDSDIESDSEIELELETDLDREIREKITMKLSRTKYACSTLFRLRSIINFVYKGYLSRPLDGKIKTVVIKHAEPFLAVNRAWDLRTDRCTGEGTVIRALNEMFDVRVTNITRFKGTFRTIVRAPELYHINYAAHILIMEHLPDAINLHKFLTNMLCLSDERLHSWCFFIGSNLGHWLHAFHEWIANDQQKQLAKDFDNSLNKAMADLKFHINYEKLLDAVEKYPKILNKKKTRRIFRKVVEMARAEVRERSKNGRTGPIHGDFWAGKLSSIILPITALQDLEKDPKPDPDAEDDPRHIPCPQATLLITDWEFAQYGPHALDIGRMVAELYMLHHFQGIEAASSMLEGFLDGYEHITMETSYRMLIHIGVHFIVWGSRRANGVGTEKQVRKLIKLGRKFIVKGWKRDRYAFMGDFWNCLFKGYSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B308</accession>
    <accession>C8V807</accession>
    <name>Q5B308_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_05072</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF76149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_662676.1">
        <property type="nucleotide sequence ID" value="XM_657584.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B308"/>
    <dbReference type="GeneID" id="2872868"/>
    <dbReference type="KEGG" id="ani:ANIA_05072"/>
    <dbReference type="HOGENOM" id="CLU_1503419_0_0_1"/>
    <dbReference type="InParanoid" id="Q5B308"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="9"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF76149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="179" mass="19610" checksum="2D5280BEA7A5ECF9" modified="2005-04-26" version="1">MGLRHSVLFPLRGSCPGESPSPSPTGWPRRPRHRGLDLLNPTRQEIGWIMLSENPLGFGILKGYVTIEEMRENLGSNLSHQYTTIGEGYEEIPTVQGAAKPSHDSCNTEYEPSFAIVGIDSDIQLGLERSAEDLYPASSSRPSKFSNEPGKGELLMELISVTGSDACFRAALMKSWVTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="105" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B340</accession>
    <accession>C8V844</accession>
    <name>Q5B340_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Zn(II)2Cys6 transcription factor (Eurofung)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ANIA_05040</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF76223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_662644.1">
        <property type="nucleotide sequence ID" value="XM_657552.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B340"/>
    <dbReference type="STRING" id="227321.Q5B340"/>
    <dbReference type="GeneID" id="2872839"/>
    <dbReference type="KEGG" id="ani:ANIA_05040"/>
    <dbReference type="eggNOG" id="ENOG502SM98">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013296_0_0_1"/>
    <dbReference type="InParanoid" id="Q5B340"/>
    <dbReference type="OMA" id="KLACDHQ"/>
    <dbReference type="OrthoDB" id="4898680at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF40">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="56"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CBF76223.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="115" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B3E7</accession>
    <accession>C8V9D2</accession>
    <name>Q5B3E7_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Zn(II)2Cys6 transcription factor (Eurofung)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ANIA_04933</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF76447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_662537.1">
        <property type="nucleotide sequence ID" value="XM_657445.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B3E7"/>
    <dbReference type="GeneID" id="2872731"/>
    <dbReference type="KEGG" id="ani:ANIA_04933"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN4933"/>
    <dbReference type="eggNOG" id="ENOG502RJUK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052542_1_0_1"/>
    <dbReference type="InParanoid" id="Q5B3E7"/>
    <dbReference type="OMA" id="CQYGFAN"/>
    <dbReference type="OrthoDB" id="1393670at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050675">
        <property type="entry name" value="OAF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069:SF31">
        <property type="entry name" value="MONODICTYPHENONE CLUSTER TRANSCRIPTION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069">
        <property type="entry name" value="OLEATE-ACTIVATED TRANSCRIPTION FACTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="23"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="57"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="61"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="78"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBF76447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="357" mass="39319" checksum="4D1FA46DC538C87C" modified="2005-04-26" version="1">MLTESGTSSSSPGNGETPKLRTACENCRQSKVKCNLSGKDTCIRCLRHGLPCRYRVANRSGKPKGSKNRSTLRKLGQLQENKSAFTSSDRLPKRNIEAIPSPGFARSDTESLPTEQPLESPMGEMQDAALFLADCEYPSPYGESLADSSCAASMSPTFLQKEFITKGLTSFPLAVHVPSALRPTCECAETLVFYHDSLRQMVVNPAQVRFDQMLQGVQAALSVCRGFLQCPSGHKDNHSANDTSIILCMSTLEFTLQLLDYWTSYELLPQSREGPREVGYGEYEMEADEARRVRRFLIRGRLLLCKETLGLLKGAAGFEDGPGGNWLQQIIGGSEAMTDTFLHAMSEAECLCNLPTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="116" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B3Y2</accession>
    <accession>C8VAS6</accession>
    <name>Q5B3Y2_EMENI</name>
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        <submittedName>
            <fullName evidence="8">RNA binding protein (AFU_orthologue AFUA_3G06310)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ANIA_04748</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF76872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_662352.1">
        <property type="nucleotide sequence ID" value="XM_657260.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B3Y2"/>
    <dbReference type="STRING" id="227321.Q5B3Y2"/>
    <dbReference type="GeneID" id="2872547"/>
    <dbReference type="KEGG" id="ani:ANIA_04748"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN4748"/>
    <dbReference type="eggNOG" id="KOG0118">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037639_3_1_1"/>
    <dbReference type="InParanoid" id="Q5B3Y2"/>
    <dbReference type="OMA" id="IKAHFAS"/>
    <dbReference type="OrthoDB" id="167718at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043024">
        <property type="term" value="F:ribosomal small subunit binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033592">
        <property type="term" value="F:RNA strand annealing activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034057">
        <property type="term" value="F:RNA strand-exchange activity"/>
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        <property type="entry name" value="RRM_Nop6"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="RRM_MRD1_RNA_proc_ribogen"/>
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        <property type="entry name" value="RNA-BINDING MOTIF PROTEIN 14B"/>
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        <property type="entry name" value="RNA-BINDING PROTEIN 28"/>
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        <property type="entry name" value="RRM"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
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        <location>
            <begin position="196"/>
            <end position="279"/>
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    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
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        <location>
            <begin position="1"/>
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            <begin position="127"/>
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    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="144"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="290"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
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    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50102"/>
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        <source>
            <dbReference type="EMBL" id="CBF76872.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
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    </evidence>
    <sequence length="339" mass="38646" checksum="78BA64B65A519D21" modified="2005-04-26" version="1">MAEKKRKLENPPEDVAATEPEGKKAKRESKKEGKKDKKDKKDKKDKKRKVQDVDVVSIEDKETELKEKKDKKEKRDKKDKGDKKEKKEKQEPKEKKSKDGLADDEEQPTAKANGAEPEPEISKDAPDAMDIDGEEEVKETSGKEKKKKKGKKAKKAKSQEEQEQTGEQGNPQSEEKEKAEQGSKQTVAPKQKAARFIVFVGNLPYSANTESLSAHFEKIQPISVRVATQPDKPTKCRGFGFVEFDNYDRMKTCLKLYHHSSFDDGKYPPRRINVELTAGGGGKSEHRKAKIEYKNQKLAEERKRQAKETKTEKVNKAKAEEKPNDDYANIHPSRRPRMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="131" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B3Y7</accession>
    <accession>C8VAT1</accession>
    <name>Q5B3Y7_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RacA (Eurofung)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ANIA_04743</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
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        <property type="protein sequence ID" value="CBF76882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OrthoDB" id="8830751at2759"/>
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        <property type="component" value="Chromosome III"/>
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        <property type="term" value="C:cell projection"/>
        <property type="evidence" value="ECO:0000318"/>
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    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
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    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
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    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
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        <property type="project" value="GO_Central"/>
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    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
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        <property type="term" value="F:GTPase activity"/>
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        <property type="term" value="F:protein kinase binding"/>
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        <property type="term" value="P:actin filament organization"/>
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        <property type="term" value="P:cortical cytoskeleton organization"/>
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        <property type="term" value="P:establishment or maintenance of cell polarity"/>
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        <property type="term" value="P:regulation of actin cytoskeleton organization"/>
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        <property type="term" value="P:regulation of cell shape"/>
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        <property type="evidence" value="ECO:0007669"/>
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        <property type="entry name" value="Ras-related C3 botulinum toxin substrate 1"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
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    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
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    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
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    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
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        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
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        <property type="entry name" value="RAB"/>
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        <property type="match status" value="1"/>
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    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1" id="KW-0488">Methylation</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0636">Prenylation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBF76882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="199" mass="22187" checksum="FABB6052BEB686A6" modified="2005-04-26" version="1">MATGPATQSLKCVVTGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYTASVMVDGRPISLGLWDTAGQEDYDRLRPLSYPQTDVFLICFSIVSPPSFDNVKSKWFPEIEHHAPNVPIILVGTKLDLRDDPAQLESLRMRKQEPVTYEQALAVAKEIRAHKYLECSALTQRNLKSVFDEAIRAVLNPRPATKQRNKKCTIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B498</accession>
    <accession>C8V7Q4</accession>
    <name>Q5B498_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cytoplasm to vacuole targeting Vps64, putative (AFU_orthologue AFUA_2G02420)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ANIA_04632</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF77106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_662236.1">
        <property type="nucleotide sequence ID" value="XM_657144.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B498"/>
    <dbReference type="FunCoup" id="Q5B498">
        <property type="interactions" value="89"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5B498"/>
    <dbReference type="GeneID" id="2872432"/>
    <dbReference type="KEGG" id="ani:ANIA_04632"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN4632"/>
    <dbReference type="eggNOG" id="KOG3872">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021864_0_0_1"/>
    <dbReference type="InParanoid" id="Q5B498"/>
    <dbReference type="OMA" id="VEHAGFM"/>
    <dbReference type="OrthoDB" id="687730at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd22679">
        <property type="entry name" value="FHA_SLMAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051176">
        <property type="entry name" value="Cent_Immune-Sig_Mod"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15715">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 170 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15715:SF46">
        <property type="entry name" value="TO VACUOLE TARGETING VPS64, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G02420)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="718"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="domain" description="FHA" evidence="3">
        <location>
            <begin position="189"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="315"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="402"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="524"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="665"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="316"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="440"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="479"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="524"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="683"/>
            <end position="694"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBF77106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="746" mass="80790" checksum="882DCBC7C681A34F" modified="2005-04-26" version="1">MTAVASPPSVQTGPRLGWYDSGDGGQGALSSMNPDEVSRMFMPRKTLHRSNSSSSIGSNSSASTIAASPSNTDAGQFANGDSATAASKKKSSRSVWPSSKSEPVSGISNARSQAKPAFFSGTGASSAMSAVQQPSSILPSQHLLQSSQQNGVRAGSTPAGDPPAILTLIPLNGTFEKKQITLPYFPETLRIGRQTNAKTVPTSKNGFFDSKVLSRQHAEIWADRATGKVLIRDVKSSNGTFLNGQRLSPENRESEAHEIRENDTLELGIDIVSEDQKTIVHHKVSAKVEHAGVYGTVPNIFDLTLGDLDPASGNGLLPSPLSQPLSHLRGRAGSASSTRSAQSNASSQFNALQQQRQMNYWSSPLSIEQVVKRLTSEMKQAKQQQQELRQTDEFLTGLMKSGAAEKEKQKHSSGDSISSRQVNGRPKMPRVDSFSRFSEPPAPPPQQPLPEKPDALPRNGVDAISPLKRTDTEKPKMSAGSSPVSRESSQILSLIEALSSAKRELDTQGARVKELEQLLQQERLARESAEQKAKSLELVSAKGSDRPSALRQDSQADGFPQNPDHEMTVNKPDSQSIDEPAVQEQGHTPAEDQTEKLQRRLETMMEDMEAMRKQLSSYKERAEKAEAETGEARKSLVEMIETLRKERAAVRDREPLLPVRDTKFLNDTSHVDEEPTAAVNHSDVGSQDATSSPRSKGADTGTELATQPHKRLDAVEQASPLASMLGVVLLGVGLMAYLNGWQKMDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B578</accession>
    <accession>C8V992</accession>
    <name>Q5B578_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_04302</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF77807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_661906.1">
        <property type="nucleotide sequence ID" value="XM_656814.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B578"/>
    <dbReference type="STRING" id="227321.Q5B578"/>
    <dbReference type="GeneID" id="2872099"/>
    <dbReference type="KEGG" id="ani:ANIA_04302"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN4302"/>
    <dbReference type="eggNOG" id="ENOG502S1UN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017096_0_0_1"/>
    <dbReference type="InParanoid" id="Q5B578"/>
    <dbReference type="OMA" id="GRIYWFK"/>
    <dbReference type="OrthoDB" id="14339at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37332:SF1">
        <property type="entry name" value="ELMO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37332">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF77807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="313" mass="33773" checksum="61541ADA3A149B1B" modified="2005-04-26" version="1">MSAGRGQGSFGKTIDMLPSTFAPTLSRRDTNKSIGHEAGAGSIPPPLISGGGSLGPQSAAAIYQHIQDMATKRISTLDYLRKAHEGRIYWFNTVHYSRADMGRMPYFDARKLTRRAINYLLLGLSIPAIIDVSTTSGEYLRALNALLIEFEAFQQVHPPEGSSSSTLARARIPQMFKRATHGGTKARRASSATEIGLPMQHSDPSDLKNMAGSAASSVSAAAASVSIPNSEASELLPGEEYSYLLTPSLPFEPDYFETFVTLCDVLIDCYTRLVTLISTPAVCTVALGELFTKADAKIRKIIVAGMLYFVVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="122" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B5H3</accession>
    <accession>C8V4C5</accession>
    <name>Q5B5H3_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">AP-1 complex subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">ANIA_04207</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="9">Adaptor protein complex 1 (AP-1) is a heterotetramer composed of two large adaptins (gamma-type subunit APL4 and beta-type subunit APL2), a medium adaptin (mu-type subunit APM1) and a small adaptin (sigma-type subunit APS1). AP-1 interacts with clathrin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF74480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_661811.1">
        <property type="nucleotide sequence ID" value="XM_656719.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B5H3"/>
    <dbReference type="FunCoup" id="Q5B5H3">
        <property type="interactions" value="649"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5B5H3"/>
    <dbReference type="GeneID" id="2873629"/>
    <dbReference type="KEGG" id="ani:ANIA_04207"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN4207"/>
    <dbReference type="eggNOG" id="KOG1062">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003824_0_0_1"/>
    <dbReference type="InParanoid" id="Q5B5H3"/>
    <dbReference type="OMA" id="AICAMRI"/>
    <dbReference type="OrthoDB" id="28053at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030121">
        <property type="term" value="C:AP-1 adaptor complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035615">
        <property type="term" value="F:clathrin adaptor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016482">
        <property type="term" value="P:cytosolic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000030">
        <property type="entry name" value="AP-1 complex subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050840">
        <property type="entry name" value="Adaptor_Complx_Large_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017107">
        <property type="entry name" value="AP1_complex_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008152">
        <property type="entry name" value="Clathrin_a/b/g-adaptin_app_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013041">
        <property type="entry name" value="Clathrin_app_Ig-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008153">
        <property type="entry name" value="GAE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22780">
        <property type="entry name" value="ADAPTIN, ALPHA/GAMMA/EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02883">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037094">
        <property type="entry name" value="AP1_complex_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00809">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49348">
        <property type="entry name" value="Clathrin adaptor appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50180">
        <property type="entry name" value="GAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="GAE" evidence="12">
        <location>
            <begin position="724"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="601"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="688"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="608"/>
            <end position="620"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00062546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR037094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CBF74480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="839" mass="92631" checksum="F13539781DE145AB" modified="2005-04-26" version="1">MASLKQFIRNVRSAKTIADERAVIQKESAAIRASFREESHDSSIRRNNVAKLLYLFTLGERTHFGQIECLKLLASHRFADKRLGYLGTMLLLDENQEVLTLVTNSLKNDLNHSNQYIVGLSLCTLGNIASVEMSRDLFTEVESLLSTANPYIRRKAALCAMRICRKVPDLQEHFLEKAKNLLSDRNHGVLLCGLTLVIDMCEAEESEEGQEGVIEMFRPLAGNLVRALKGLTTSGYAPEHDVSGITDPFVQVKILRLLRVLARGDTATSELINDILAQVATNTDSSKNVGNAILYEAVLTILDIEADSGLRVLGVNILGKFLTNKDNNIRYVALNTLNKVVAIEPNAVQRHRNTVLECLRDPDISIRRRALDLSFMLINESNVRVLVRELLAFLEVADNEFKPTMTTQIGIAADRYAPNKRWHADTILRVLKLAGAYVKEQILSSFVRLIATTPELQTYSVQKLYVSLKEDISQEGLTLAATWLIGEYGDNLLRGGEYEEEELVKEIKESDIVDLFDNILNSTYATQTVVEYITTASMKLTVRMSDASQIERLRRLLHNRTADLSVEIQQRAVEYGNLFGYDQIRRGVLERMPPPEIREEQRVLGPSTKKRQSKMLKDKTRKPIKTAEQDMLLDLMGGSDVPVTSPTMNGSQNTADLLADILGGDSGLSSPAPQAAQQPVSNNSAIMDLFGSNGGTPSPNPAPASASLDLLGGAGAPVSTPSPSTSTAYTAYNKNELVLSLQVQRGNNNTAQIQARFRNQSSFSQFTSVGLQAAVPKSQRLQLSAINKAELEAGDEGVQMLKVTALNGPLPSKLRLRLRVTYAKDGSEPTTDQVDWSES</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B653</accession>
    <accession>C8V5W9</accession>
    <name>Q5B653_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">LysM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ANIA_03977</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
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            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
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    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
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        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
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                <person name="Tanaka T."/>
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                <person name="Asai K."/>
                <person name="Machida M."/>
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                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
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    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
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                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
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                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
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                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
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                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="532" mass="58736" checksum="768DAA7794A06798" modified="2005-04-26" version="1">MNSIYKGPRPIPASADSRSKLDAFRYKNNNQNGTAMSPKKTTPHKGHTNKENQTSWLNGVVEQDKSESDNRQNLQEGPEPKAVKDCPQTPGNRLPLADLIGNAEDAFSRAPMAQEFTPEDYVIWQHAPPSSNPSTQTPATQSKKRRHSSSPSSSPLAGSKGARKGSFDLQSIQALLKTPQNDLATDLWNNYVAKTAVNVTDLQQPRFAGLLSSSPRTPTSARAGQDSSGLRRSISCNAEWPSTKAKRRRVEGESPRKGRAIFSRTRSNIMVPKDLKTSNFSSLVQEMERSLKKAIPKYSDTSKTAPAIAHTETRRSRSASPLETRLAKGPVREAILDNEVNCALPSANQKPPQDSSSEFGDDDLDEFLGLANVSDPFVDHNQVGSKLEPHNTNFDHSLPSMGKDEQSFDNKNNDSHAQSHKDLKPASNNDTDNPDNDEFDDYFEGLSDNLEELLAGCDQTPHTKLTSAVQQHLPTSDHRPEKPPTLGTELRYEINEQLITSSDEFDDDDFDIDCLDQPILQGEDSPDDVRHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B815</accession>
    <accession>C8VHY4</accession>
    <name>Q5B815_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ANIA_03315</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF82971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_660919.1">
        <property type="nucleotide sequence ID" value="XM_655827.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B815"/>
    <dbReference type="STRING" id="227321.Q5B815"/>
    <dbReference type="GeneID" id="2873812"/>
    <dbReference type="KEGG" id="ani:ANIA_03315"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN3315"/>
    <dbReference type="eggNOG" id="ENOG502SH56">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003121_2_1_1"/>
    <dbReference type="InParanoid" id="Q5B815"/>
    <dbReference type="OMA" id="ASHTEAC"/>
    <dbReference type="OrthoDB" id="4357582at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37535">
        <property type="entry name" value="FLUG DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37535:SF3">
        <property type="entry name" value="FLUG DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF82971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="570" mass="66325" checksum="52DAD3C4B3F70BF6" modified="2005-04-26" version="1">MAQQPVARFTRVIDLDEHDDKEIKRAILPRTSRKYDRALRIFDRFLELHPAACFPPDIKSYKGFLEFYARNTTGRIEEQPITETIENFRRDFETALARARGIQVPKSTSITMKEYIISDLKTKLGLPDVQMSRDGLSPNDLTILLTQLWCRDFKEYRGKFPDRNRVQLTASILLYCFSSARTGEVHESTARRSIARQKDGDNSNDANLRAYSMAACYKHFILTIELVEGIPMLVLTYAREFVKGYWRLRKWEPPVHAFYEVYKEDVPLFFNLILFMLPLFSADRAFRYYGSYTEILDQLDSIKLSDLASQDNHVISRIHFRKDILDTPVFRPSSELDIQSSTECYCPCMSSMGTHGNWQTARMKHASHTEPRTFGRSYAHPVCEVDGPATYLNIASRHEHIQNRRSMGIHHNPNLWQSLPAKAEFEFQEREDIMALDEELKSLTAKLVDARADGPEAERKIQLERRHDSHVGSVYKQTLFCYYRRAMPERDRLAQLLPSKSSMRSPAGRDAMIDLETICREHSPVAYRTNLQPINGNLNLSPIQRMEQYLDMMPQSEDELSRWKNQHTND</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="125" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B822</accession>
    <accession>C8VHZ3</accession>
    <name>Q5B822_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">alpha-amylase</fullName>
            <ecNumber evidence="4">3.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">ANIA_03308</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="19">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endohydrolysis of (1-&gt;4)-alpha-D-glucosidic linkages in polysaccharides containing three or more (1-&gt;4)-alpha-linked D-glucose units.</text>
            <dbReference type="EC" id="3.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.1" evidence="4"/>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF82987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_660912.1">
        <property type="nucleotide sequence ID" value="XM_655820.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B822"/>
    <dbReference type="STRING" id="227321.Q5B822"/>
    <dbReference type="CAZy" id="GH13">
        <property type="family name" value="Glycoside Hydrolase Family 13"/>
    </dbReference>
    <dbReference type="GeneID" id="2874400"/>
    <dbReference type="KEGG" id="ani:ANIA_03308"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN3308"/>
    <dbReference type="eggNOG" id="KOG0471">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006462_7_2_1"/>
    <dbReference type="InParanoid" id="Q5B822"/>
    <dbReference type="OMA" id="NAQLCQT"/>
    <dbReference type="OrthoDB" id="204980at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004556">
        <property type="term" value="F:alpha-amylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11319">
        <property type="entry name" value="AmyAc_euk_AmyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000120">
        <property type="entry name" value="Alpha-amylase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013777">
        <property type="entry name" value="A-amylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015340">
        <property type="entry name" value="A_amylase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357:SF220">
        <property type="entry name" value="ALPHA-AMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357">
        <property type="entry name" value="ALPHA-AMYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09260">
        <property type="entry name" value="A_amylase_dom_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001024">
        <property type="entry name" value="Alph-amyl_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8 14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010219500" description="alpha-amylase" evidence="16">
        <location>
            <begin position="25"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="17">
        <location>
            <begin position="37"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="12">
        <location>
            <position position="234"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="12">
        <location>
            <position position="258"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="324"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="371"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="13">
        <location>
            <position position="324"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="54"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="178"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="268"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="466"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001024-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001024-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001024-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR001024-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CBF82987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="552" mass="61090" checksum="6D006C49C4CCFC72" modified="2005-04-26" version="1">MKILPSLRLAYIMTVLSVLNISNAATTAEWKARSIYQTMTDRFARTDGSTTHACNTTAGLYCGGTWRGTINHLDYIQGMGFDAVMISPIIENIGGRVSYGEAYHGYWPLDLYSLNDHFGTHQDLLDLSAALHERGMYLMMDTVINNMAYMTDGDDPAKNIDYSALTPFNKSEYYHPYCKIKDWNDYHDAQWCQTGDNKVALPDLYTERKDVQDTLISWAKGIVKTYSIDGLRIDAAKHVNTGFLKTFSDSVDMYVTGEVLQREVDIICNYTENYIDSVPNYPIYYSMLDAFTQGNTTSLYHQVENMKKSCRDVTTLVSFSENHDVARVPSFNDDMALAKNILTFTILFDGIPMIYQGQEQHLSGDGTPKNRQAVWLSAYNTDSELYKLIATLNKIRKHVISLGSDYLDEQTVPLYRGGSELAFSKGVEGRQIIMLLSGQGSKGDPYTLTLPVSYNAGTTVTDVLHCVNYTSVGSGERAGELDVPMSKGEPRVFFPADLMEGSGLCGHAGGNVSLAKLETGKDRVVSGGRIVGEANATLVMIMSVLAGVLLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="142" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B883</accession>
    <accession>C8VI58</accession>
    <name>Q5B883_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">ABC multidrug transporter (Eurofung)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">ANIA_03247</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF83105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_660851.1">
        <property type="nucleotide sequence ID" value="XM_655759.1"/>
    </dbReference>
    <dbReference type="GeneID" id="2874079"/>
    <dbReference type="KEGG" id="ani:ANIA_03247"/>
    <dbReference type="eggNOG" id="KOG0065">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_35_0_1"/>
    <dbReference type="InParanoid" id="Q5B883"/>
    <dbReference type="OMA" id="QILWGEK"/>
    <dbReference type="OrthoDB" id="245989at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03233">
        <property type="entry name" value="ABCG_PDR_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03232">
        <property type="entry name" value="ABCG_PDR_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001465">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000054">
        <property type="entry name" value="ABC multidrug transporter atrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034001">
        <property type="entry name" value="ABCG_PDR_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034003">
        <property type="entry name" value="ABCG_PDR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010929">
        <property type="entry name" value="PDR_CDR_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06422">
        <property type="entry name" value="PDR_CDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="588"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="733"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1180"/>
            <end position="1197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1217"/>
            <end position="1250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1262"/>
            <end position="1283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1289"/>
            <end position="1309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1321"/>
            <end position="1341"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="119"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="811"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="24"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="770"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="770"/>
            <end position="781"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CBF83105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="1457" mass="162026" checksum="794F710CEEEB31E2" modified="2005-04-26" version="1">MDNDGPPEKEQTPASNLHQVYSQEKRVADSHDTLVVPPGTPTGATSTETLALAHPYPPTTSTAPVKNTTWRLTDQVVKNRDRDRAAGYKPRELGVTWQGLSVEVPTAEASVNENLFSQFNIPQVAKDYFRKPPVRPILSDSHGCVKPGEMLLVLGRPGSGCTTLLNLLSNRRQGYRMIKGDVRFGTMDPKEAERYRGQIVMNTEEELFYPHLQVGATMDFATKLKVPAHLPDGADSIDGYVKETKDFLLESMGISHTAHTKVGNEFVRGVSGGERKRVSIIECLATRGSVFCWDNSTRGLDASTSLEWAKALRAMTDVNGLATIVTLYQAGNGIYNLFDKVLVLDEGKQIYYGPAAEAKPFMEELGFVYTEGGNIGDFLTGVTVPTERRIKPGYESRFPRNADEIRALYEKSPIYSQMIAEYDYPQTPLAKERTEAFKESVAWEQAKELPKGSSLTVGFWSQLLACTIRQYQILWGEKSTFLMKQVLSLAMALIAGSCFYDAPDDSSGLFIKGGGVFFAVLYNNIVAMSEVTESFKGRPVLVKHKSFAMYHPAAFCLAQIMADFPVLLFQCTIFSVVMYWMIGLKHTAAAFFTFWAILFTITLCLTAMFRCIGAAFKTFEAASKISGTAVKGIVMYAGYMIPKPDVRNWFVELYYTNPFAYAFQAALSNEFHDQHIACVGENLIPSGPGYEDVGAGHQACAGVGGALPGAAYVTGDQYLGSLHYKFTQLWRNYGVVWGFWGLFAVLTIIFTTFWNAGAGSGSTLFVPREKIKQHQRHKDEESQSQVGAATARDGGDTSLDEGNISRNTSIFTWQNLTYTVNTPTGERVLLDKVNGYVKPGMLGALMGSSGAGKTTLLDVLAQRKTDGTIKGSIMVDGRPLPVSFQRSAGYCEQLDIHEEYATVREALEFSALLRQPRTTPREEKLKYVDTIINLLELQDLADTLIGGVGNGLSVEQRKRVTIGVELVAKPSILIFLDEPTSGLDGQSAYNTVRFLRKLADIGQAILVTIHQPSAQLFAEFDTLLLLARGGKTVYFGDIGENGRTIKQYFGKYGAQCPVEANPAEFMIDVVTGAIPEVKDNDWHQIWLESPENAKMIKDLEDMIADAASKPPGTHDDGFEFSMPLWEQIKIVTHRMNVSLYRNTNYINNKFSLHIISALLNGFSFWRAGPKTGVSDLNLKMFSIFNFVFVAPGVINQLQPLFIQRRNIYDAREKKSKMYSWISFVIGLIVSEFPYLCVCAVLYFLCWYYCVKLPYDSSRAGSTFFIMLIYEFIYTGIGQTIAAIAPNATFAALVNPLIISILVLFCGVFVPYTQMNVFWKYWLYYLNPFNYVVSGMLTFGIWGNNVICNDDEYARFDPVNGTCAEYLKDYVTGSGWAINLANPEATSDCRVCQFRDGSDFLTTLNIKHYYYGWRDAGICVIFAISGLHRVLALGIQRISVQVSAMNTRDVTCFRALLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="99" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B932</accession>
    <accession>C8VJ30</accession>
    <name>Q5B932_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glutathione S-transferase, putative (AFU_orthologue AFUA_3G07930)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_02948</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF83691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_660552.1">
        <property type="nucleotide sequence ID" value="XM_655460.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B932"/>
    <dbReference type="GeneID" id="2873903"/>
    <dbReference type="KEGG" id="ani:ANIA_02948"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN2948"/>
    <dbReference type="eggNOG" id="ENOG502SAAV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011226_4_2_1"/>
    <dbReference type="InParanoid" id="Q5B932"/>
    <dbReference type="OMA" id="DAGHQWL"/>
    <dbReference type="OrthoDB" id="4951845at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd03038">
        <property type="entry name" value="GST_N_etherase_LigE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054416">
        <property type="entry name" value="GST_UstS-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22041">
        <property type="entry name" value="GST_C_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="23"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="Glutathione S-transferase UstS-like C-terminal" evidence="2">
        <location>
            <begin position="124"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF83691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="268" mass="30159" checksum="F6AE1344F3E04742" modified="2005-04-26" version="1">MAKQVPVHFFDILSTLPGPCKAWSPNTYKTRLILNYKGIPYTQTYVSYPDIAPLLKGLSVPPHPKGTAPFDYTLPAICHPSVKSTPSGAMNDSLPIARHLEEHFPERPIFPSGDASYALAVAINKLMGRVGFAAYRLVIVPIADILDPRGKEYYHRTRSEKWGMPFEEIRPTDEKQCQEMLETAKTEKATIVQMLKGKTGKTGPFFEGEKAGYADFLVMAFLVWFKTADEKVWKALVELGDGEVKALWDACYQWVEGQGENKDWKIDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="102" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B9K1</accession>
    <accession>C8VJM1</accession>
    <name>Q5B9K1_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Amidohydrolase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_02779</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF84030.1"/>
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    <dbReference type="KEGG" id="ani:ANIA_02779"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
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        <property type="component" value="Chromosome VI"/>
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    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01299">
        <property type="entry name" value="Met_dep_hydrolase_A"/>
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        <property type="entry name" value="Uncharacterized protein"/>
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        <property type="entry name" value="Metal-dependent hydrolases"/>
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        <property type="entry name" value="Urease, subunit C, domain 1"/>
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        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
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        <property type="entry name" value="Metal_Hydrolase"/>
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        <property type="entry name" value="Metallo-dep_Hydrolase"/>
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    <dbReference type="InterPro" id="IPR057744">
        <property type="entry name" value="OTAase-like"/>
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    <dbReference type="PANTHER" id="PTHR43135">
        <property type="entry name" value="ALPHA-D-RIBOSE 1-METHYLPHOSPHONATE 5-TRIPHOSPHATE DIPHOSPHATASE"/>
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        <property type="entry name" value="ALPHA-D-RIBOSE 1-METHYLPHOSPHONATE 5-TRIPHOSPHATE DIPHOSPHATASE"/>
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        <property type="entry name" value="Amidohydro_1"/>
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    </dbReference>
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        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="1">
        <location>
            <begin position="104"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF84030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="493" mass="54653" checksum="291613D231CC0971" modified="2005-04-26" version="1">MPLTWSSPDYPLEPYNGPPRNIAYIEQLDFGKEVQPKPYNIAGTHPDSRVLITDIKILDATGREPYHGDVLITGERFTHVGTVPNKEDLLRDPRVRVFYGNGRTLIPGLGDAHTHLSWNGGDLGRLGELGVEEHTLLTARSARCFLDSGYTMCFGAASAKRRLDVVVRDAINAGDIPGPRYLANGQEMARRDGDLVPGITAYADGPEEMREVIREHVKLGVDQVKLSMSGESITEIRDAMDCYFSDEETKACVDEAHKHGIRLCAHARARDSVRQCIKHGVEIIYHGSYIDEEVTAAGMDALEKKRSQHVVVPAINWLYATLYEAGAFGYATEAAEKVGYKKELEAAIRGLREMHRRGIVVLPGGDYGFAWTPHGTYARDLEHFTKLLGFTPHEAIIAATYGVAKLFMRSHEMGQIKAGNFADCVLVDGDPLDDITVLQDHSRLNVIMINGRVHKAGRRELLAPNIAASQELTQRITQAVDELEIKTPMQKAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BA06</accession>
    <accession>C8VHS5</accession>
    <name>Q5BA06_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_02624</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF84344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_655136.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BA06"/>
    <dbReference type="GeneID" id="2874543"/>
    <dbReference type="KEGG" id="ani:ANIA_02624"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN2624"/>
    <dbReference type="HOGENOM" id="CLU_1686546_0_0_1"/>
    <dbReference type="InParanoid" id="Q5BA06"/>
    <dbReference type="OrthoDB" id="2428527at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030175789" evidence="1">
        <location>
            <begin position="20"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF84344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="156" mass="17382" checksum="B8F45804774FBF1E" modified="2005-04-26" version="1">MAESAFLLFLRLSAGFTSASLPAQYPSLFKKRIMSKKTIYSIWARMDIAGCATGICGHIIFNFAENIAPEAQWQGAYSYILLVVSLCGHDDLCSLHTRHFLCHHAYQTELLGAAVCIDISNALRNGNVFSRMQCSSFQRDTSRTSRSHEAKRVDAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BA92</accession>
    <accession>C8VPM1</accession>
    <name>Q5BA92_EMENI</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_02538</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF87054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_660142.1">
        <property type="nucleotide sequence ID" value="XM_655050.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BA92"/>
    <dbReference type="GeneID" id="2875721"/>
    <dbReference type="KEGG" id="ani:ANIA_02538"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN2538"/>
    <dbReference type="HOGENOM" id="CLU_616810_0_0_1"/>
    <dbReference type="InParanoid" id="Q5BA92"/>
    <dbReference type="OMA" id="QITIAFH"/>
    <dbReference type="OrthoDB" id="4507588at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="186"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="229"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="259"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="302"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="336"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="380"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="408"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="432"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF87054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="444" mass="48498" checksum="0E0E4D6F62144493" modified="2005-04-26" version="1">MSSFSLDDYLDDLSDYGFDYSDFGLDDEDFDYSDYLNDDDFDYSDYGLDDEDFDFDYSDYLPSSTSSASYPTSTSYDWLSGGDSGDDGDITTPSSSDYDMNLDGTPPNGEGSTNGLPSSLGGAFGSDFSNQQVSDSCVSEVAFKTTAPKVDLAFDVIFLVLFIALAVFTVIRLFKIKRNGGGMVNWVLFPISLFFTILYLFLDTITLILSECVMMRGDKYWDAQTAVQWFSRLAIFLLIVIIMLPICRKLQQGGGIFATLTLVLHSLWIALTGIFLIVSLALTTRVRVGDRDGFKLEKASNGVTMAYSVFLFIAALLALVNMGIALVKKANLRKGLTLITIPVLALSTLILTLILMGGFADNVYGSKNRSAKYFQQSGDAQTFLARLFYAVSFVSALFVAGANTANDDAAQSAPSMTQTPKPAEYYQPQPQPVTTAPVPAPAQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="134" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BB24</accession>
    <accession>C8VMV4</accession>
    <name>Q5BB24_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">SNF2 family helicase, putative (AFU_orthologue AFUA_5G06590)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">ANIA_02256</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="16">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF86480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_659860.1">
        <property type="nucleotide sequence ID" value="XM_654768.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BB24"/>
    <dbReference type="STRING" id="227321.Q5BB24"/>
    <dbReference type="GeneID" id="2874756"/>
    <dbReference type="KEGG" id="ani:ANIA_02256"/>
    <dbReference type="eggNOG" id="KOG1001">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000315_2_5_1"/>
    <dbReference type="InParanoid" id="Q5BB24"/>
    <dbReference type="OMA" id="ETTVWRL"/>
    <dbReference type="OrthoDB" id="448448at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd18008">
        <property type="entry name" value="DEXDc_SHPRH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014905">
        <property type="entry name" value="HIRAN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF11">
        <property type="entry name" value="FAMILY HELICASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G06590)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08797">
        <property type="entry name" value="HIRAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00910">
        <property type="entry name" value="HIRAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 15" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="402"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="730"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="801"/>
            <end position="968"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
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    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CBF86480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="972" mass="108899" checksum="C341E8A25644C723" modified="2005-04-26" version="1">MAERSKAPDSRKRFSYLNKVSGLRKRAPGWYILIRLQLTRSPTKLEVPLQPKIMESRSTKRSIHLVDYAPGEVHEGAPAPPPKYPRIAGQRFGQDTTFIPLSQASQVSLQEDEDDAAAADLLQDNQVVDDFSDTTQLHYGDLNTKIVGVRYYRGTATIGEHVVLKREPHNQYDRNAIRVDNVMGTQIGHIPRNMAAKLATYMDNRLLVVEGVLTGVIGAFDCPIVLKLYGPSDLERREALKQRMVQDKLPLNHLKKAERDEKKVQKEREKAVKEAAKRARKGQLLEAATNLGYSNLSQPFGEGIITEESLDELINQSSTFNPREINRVTESFGLKESDLENMPMVESPSSLSTTLLPYQRQGLAWMISKENPGLPTSDNDVVQLWKKEGNKFTNIATNFSTTAPPSLASGGILADDMGLGKTIQIISLILSNSQPKTKESSKATLIISPVGIMSNWRNQIQEHTNPEQAPRVLIYHGPGRKEDANLDHYDVVVTSYGTLATEYKTESKATPQKGLFSVKWRRVVLDEGHTIRNPRSKGFSAACALRADSRWALTGTPIVNTLKDLYSQIRFLGLTGGLEDFAVFNSVLIRPLMSDDPDSRLLLQALMSTICLRRRKDMGFVNLRLPTLTSRVLRIKFHPHEKEKYDMFQSEAKGMLLDFKSNNKTGTTYSHLLEVILRLRQVCNHWALAKNRLDKLAAILDKHQTVPLTPDNIKALQDMLQIRIESQEICPICLDILETPVITACAHAFDHDCIEQVIVRQHKCPICRAEIENKSSLVAPAADLGENTDDVSADPDNPSSKIEALIKILTAHGQVEATKTVIFSQWTSFLTLVEPHLQNAGIQFARIDGKMTSIARDRSMRRFSTDPKCTVLLASLSVCSVGLNLVAANQAILADSWWAPAIEDQAVDRVYRLGQTRETTVWRLVMEDSIEDRVLAIQEQKRKLMLAAFREKASKKVDDRATRVADLEKLLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BC92</accession>
    <accession>C8VPQ0</accession>
    <name>Q5BC92_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ANIA_01838</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF85661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_659442.1">
        <property type="nucleotide sequence ID" value="XM_654350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BC92"/>
    <dbReference type="GeneID" id="2874677"/>
    <dbReference type="KEGG" id="ani:ANIA_01838"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN1838"/>
    <dbReference type="HOGENOM" id="CLU_2061453_0_0_1"/>
    <dbReference type="InParanoid" id="Q5BC92"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF85661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="119" mass="12960" checksum="9A97F7E3DBC3A904" modified="2005-04-26" version="1">MKQTLKEHGSLYALHSATATPYRCLLDDASIVIRWRNLPVCGGGNERKYGAMGVRFLVSRDGHLRPVQYTAGCAVIPVTPIEEARCPQSEGASDAISRRRTWSLAGSGCTICKVVAQVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="107" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BCG4</accession>
    <accession>C8VPC3</accession>
    <name>Q5BCG4_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS multidrug efflux transporter (Eurofung)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ANIA_01766</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF85521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_659370.1">
        <property type="nucleotide sequence ID" value="XM_654278.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BCG4"/>
    <dbReference type="GeneID" id="2875184"/>
    <dbReference type="KEGG" id="ani:ANIA_01766"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_22_0_1"/>
    <dbReference type="InParanoid" id="Q5BCG4"/>
    <dbReference type="OMA" id="HKLHNNL"/>
    <dbReference type="OrthoDB" id="3437016at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015802">
        <property type="term" value="P:basic amino acid transport"/>
        <property type="evidence" value="ECO:0000318"/>
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        <property type="term" value="P:transmembrane transport"/>
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        <property type="entry name" value="MFS"/>
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        <property type="entry name" value="MFS_dom"/>
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        <property type="entry name" value="MFS_trans_sf"/>
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        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
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        <property type="entry name" value="VACUOLAR BASIC AMINO ACID TRANSPORTER 4"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="MFS general substrate transporter"/>
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        <property type="entry name" value="MFS"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="164"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="176"/>
            <end position="194"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="252"/>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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    <feature type="transmembrane region" description="Helical" evidence="6">
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    <feature type="transmembrane region" description="Helical" evidence="6">
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    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="380"/>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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            <begin position="142"/>
            <end position="627"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
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        <source>
            <dbReference type="EMBL" id="CBF85521.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="636" mass="68454" checksum="C48474A5D1D80E8B" modified="2005-04-26" version="1">MILMLSIPSSTIVAKFMKKAPSKYQRGCFPGRLLSGEIAFLGRIFLTSPGNVAIVQKRPNFRYWRPYAPMSFVDPSRPVRCHQLDTLTTILNLTDMSLSQSSPPTQAATARDGSISEQTPLLAGQSQPPAEEEPSTKRLLLVLCGIWVGVFLAALDITIVATLTGPISSSFNSLSLFSWLATAYLISNAACQPLSGRLTDIFGRKAGLIFSNLVFAAGNLICGLAQRQWTIILGRVIAGIGGGGLTAISTFVASDLIPLRKRGVWQGVGNICFGVGSGLGGVFGGWINDTLGWRWAFLIQIPFVLASAILVALTVKIPPKNANKDKLRRVDFLGAITLVTALVLLLLGLNTGGNQLPWTHPLILTTLPLSAVVLGAFVYIEANIASEPVIPVRLLLNRTVLSGCLTNWFTTMNVYALLFYLPILFQVQGLSATASGARLIPQAIGTSFGSLGSGALMRYSGRYKMYSHITMLLLVVSSALICTLKPDTPTALPLLYFLLGGVAYGSMLTITLVALISAVDHEHHAVITSASYAFRSTGSSIGITIGSSVFQNILRSGLWSRFGDRENAREVISRLLDSLQEIQKVPADWLPGVMDAYMVSLRATFITLLGLAVLGALVSFGMREHVLHSNMARRNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="127" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BCQ2</accession>
    <accession>C8VNS6</accession>
    <name>Q5BCQ2_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Zn(II)2Cys6 transcription factor (Eurofung)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ANIA_01678</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="CBF85351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_654190.1"/>
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    <dbReference type="eggNOG" id="ENOG502SMHU">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="InParanoid" id="Q5BCQ2"/>
    <dbReference type="OMA" id="RRYFEFA"/>
    <dbReference type="OrthoDB" id="2579025at2759"/>
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        <property type="component" value="Chromosome VII"/>
    </dbReference>
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        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Stress_Response_Reg"/>
    </dbReference>
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        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
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        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47540">
        <property type="entry name" value="THIAMINE REPRESSIBLE GENES REGULATORY PROTEIN THI5"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="545"/>
            <end position="564"/>
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            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
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    <feature type="region of interest" description="Disordered" evidence="7">
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            <begin position="77"/>
            <end position="123"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="7">
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            <begin position="637"/>
            <end position="662"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="99"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBF85351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="741" mass="84140" checksum="FE2547D11127E3D5" modified="2005-04-26" version="1">MEAGRRLSRTSEGVLVRDSPPSPRPCFTSGGRQRKLRKVTRACDACKSKKKACTGTIPCAPCVRRKLACTYNTTYQRGVAVTPPPSSSRPRHDSPNPTPQQTVLETESESTPPYAPQPSEQRATAEVVDQYWGPTSAHSFLGWAVRDLPATPSDIAQASGRDRDRTSKTSIFHFGDRVAPEVQLGDFEWPDRAEAEALARRYFDFACPTYRTLHQPTIEREIRELYREDTQFDGGRSVREQSSASHAVLLMVFSTATMFRSDANGRITDADDACWKTSELYFAKAEQLLSQEIGEPRLESAQARFLIVLYLLSSSRANKAWFTLGTTIQLMMALGLHSRRSRKDDEKDLVQRECRRRILWCSYTLDKYISVILGRPRLWHDEDLDEELPARVNDTDLLPTPIPSPKRDCVMDAPVFHALLARTLSQAAKEPYVVAGISHRDQLNTIGALCKSVAEWHARLPPLLSGSIHPSSLVPIFQRQLTVLQLARYHLLMFITRPLLLRNYGRTWPDCEASYVHHLGVCLTAARDAVEMVLTFVRENQLFHAFWYSQYIAFNALSIIYIYLIQVRRGRIPQISGSFIYEAYSFSLDEPTLYRLSETAQHHLADATSRNSPSWKYSAILQGLRRELERLGLRPPFAEASREHTEPTSVSNMAAVPNDDELPMTENSRYGHIRDPEHMAPDSSLAEPDGNYMQIPGIHRSNEQYFVDPRTEYLFDSFATDKDLMLDFWPQLDSLPIAYMG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2010-06-15" modified="2026-01-28" version="100" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BD29</accession>
    <accession>C8VMY9</accession>
    <accession>Q1HFV1</accession>
    <name>BTGE_EMENI</name>
    <protein>
        <recommendedName>
            <fullName>Probable beta-glucosidase btgE</fullName>
            <ecNumber>3.2.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Beta-D-glucoside glucohydrolase btgE</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Cellobiase btgE</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Gentiobiase btgE</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">btgE</name>
        <name type="ORF">AN1551</name>
    </gene>
    <organism>
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="11417" last="11422">
            <title>Development and application of a suite of polysaccharide-degrading enzymes for analyzing plant cell walls.</title>
            <authorList>
                <person name="Bauer S."/>
                <person name="Vasu P."/>
                <person name="Persson S."/>
                <person name="Mort A.J."/>
                <person name="Somerville C.R."/>
            </authorList>
            <dbReference type="PubMed" id="16844780"/>
            <dbReference type="DOI" id="10.1073/pnas.0604632103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S72" last="S81">
            <title>Comprehensive genomic analysis of cell wall genes in Aspergillus nidulans.</title>
            <authorList>
                <person name="de Groot P.W."/>
                <person name="Brandt B.W."/>
                <person name="Horiuchi H."/>
                <person name="Ram A.F."/>
                <person name="de Koster C.G."/>
                <person name="Klis F.M."/>
            </authorList>
            <dbReference type="PubMed" id="19585695"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.07.022"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY</scope>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Beta-glucosidases are one of a number of cellulolytic enzymes involved in the degradation of cellulosic biomass. Catalyzes the last step releasing glucose from the inhibitory cellobiose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text>Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Secreted</location>
            <location evidence="5">Cell wall</location>
        </subcellularLocation>
        <text>Covalently-linked to the cell wall.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the glycosyl hydrolase 17 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21"/>
    <dbReference type="EMBL" id="DQ490473">
        <property type="protein sequence ID" value="ABF50849.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AACD01000025">
        <property type="protein sequence ID" value="EAA64258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF85093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_659155.1">
        <property type="nucleotide sequence ID" value="XM_654063.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BD29"/>
    <dbReference type="SMR" id="Q5BD29"/>
    <dbReference type="STRING" id="227321.Q5BD29"/>
    <dbReference type="CAZy" id="GH17">
        <property type="family name" value="Glycoside Hydrolase Family 17"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CBF85093">
        <property type="protein sequence ID" value="CBF85093"/>
        <property type="gene ID" value="ANIA_01551"/>
    </dbReference>
    <dbReference type="GeneID" id="2874885"/>
    <dbReference type="KEGG" id="ani:ANIA_01551"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN1551"/>
    <dbReference type="eggNOG" id="ENOG502QS0R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027285_2_1_1"/>
    <dbReference type="InParanoid" id="Q5BD29"/>
    <dbReference type="OMA" id="VVCPYAT"/>
    <dbReference type="OrthoDB" id="4082933at2759"/>
    <dbReference type="UniPathway" id="UPA00696"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042973">
        <property type="term" value="F:glucan endo-1,3-beta-D-glucosidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050732">
        <property type="entry name" value="Beta-glucan_modifiers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631:SF24">
        <property type="entry name" value="FAMILY 17 GLUCOSIDASE SCW11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword id="KW-0134">Cell wall</keyword>
    <keyword id="KW-0136">Cellulose degradation</keyword>
    <keyword id="KW-0326">Glycosidase</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0624">Polysaccharide degradation</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000395136" description="Probable beta-glucosidase btgE">
        <location>
            <begin position="19"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="263"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="263"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="392"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="O22317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3"/>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="19585695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="6"/>
    <sequence length="555" mass="57672" checksum="B8F0DF0153079DCA" modified="2005-04-26" version="1" precursor="true">MRGAILATAAAFAGTAVADMHMRRHAHEGLHHRALHASSAVPEEECGCTTEVITYWGEPTTIPLSVPTSTVTSETTETVHSTSYSTVTVTATSSAAPVETPSETPSPTPEVTLPTAGVTSYSETGTYTIPATTITVTDTTTVCGATTTELPSGTHTYGGVTTIVETATTITCPYATVKPTGSTVTSVIETTTYVCPSAGTYTIAPTTTFVPTSTVVVYPTPETVTPGTYTNPGTTITVTRTEDVYVCPYTNGNVPTSVPALPTTSAASTTTAVPSSSTTTSSATSVPTGASGNKMGMTFTPYNNDGSCMAKNDVLEQVGLIKGKGFSHVRVYGTDCHTLEYVGAACSTHGLKMILGVNVEGSTGFDGARSQFKDITNWGQWDLVSLIVVGNEVVTSNIASAAQLASFVSEGASAFSAAGYTGQVTTAEPIDVWLSNGATLCPVVDILGANLHPFFNPEFTAAEAGTLVSNQIKDLKQVCTGKDVINLETGWPNAGSANGKAIPGQSQQTTAIKSLVEKVGDVSVFFSYADDGWKSKFATSDKYNVEQHWGCIDQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="101" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BDH3</accession>
    <accession>C8VM19</accession>
    <name>Q5BDH3_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cytoplasmic protein required for cell viability, putative (AFU_orthologue AFUA_8G03980)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ANIA_01407</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
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        <text evidence="1">Belongs to the MIP18 family.</text>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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        <property type="entry name" value="CYTOSOLIC IRON-SULFUR ASSEMBLY COMPONENT 2B"/>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="73"/>
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        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01883"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CBF84795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="201" mass="21585" checksum="5BE22C1E961268B3" modified="2005-04-26" version="1">MASEMQNSNPTIINTADLPTRLRPSASPKSSTYGSEFFASALPSLTVDALSDYSPSTSESENDDDLMEEPIDEQEIYDLVSTISDPEHPISLGALAVVSLPDISIKPALPDVPDSPLRTVTVLITPTITHCSLATVIGLGVRVRLEQSLPPRFRVNVQIKEGTHSTADEVNKQLADKERVAAALENGTLMGVIAKMLETCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
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    <accession>C8VS73</accession>
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        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF87745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_658912.1">
        <property type="nucleotide sequence ID" value="XM_653820.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="ani:ANIA_01308"/>
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    </dbReference>
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    <dbReference type="InParanoid" id="Q5BDS2"/>
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    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF87745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="177" mass="20215" checksum="868453F6D252FF25" modified="2005-04-26" version="1">MTVQHVVLSDREIEEIQRAEGQTNLIRQAQESDEADQKLTIRQAFKERFEVYNPVPDRKLIPAEWQPGLSNSTSVGQLAGLVVNAICQEGFGGHFHSCLRPVTLSTYIWRSHVRYRLGRLQTLSTTYASEAVPTCLRSHVTAYVCMCWEQGFLLWCLSSYLSVKGGLDVYRRSIEYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BE54</accession>
    <accession>C8VT18</accession>
    <name>Q5BE54_EMENI</name>
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        <recommendedName>
            <fullName evidence="5">DAGKc domain-containing protein</fullName>
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        <name evidence="6" type="ORF">ANIA_01176</name>
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    <organism evidence="6 7">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
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            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
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            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
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        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
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                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
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            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
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        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
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    <accession>Q5BEM6</accession>
    <accession>C8VU62</accession>
    <name>Q5BEM6_EMENI</name>
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            <fullName evidence="11">CT20 family protein</fullName>
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        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
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        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
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                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EAF7 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF88354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_658608.1">
        <property type="nucleotide sequence ID" value="XM_653516.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BEM6"/>
    <dbReference type="STRING" id="227321.Q5BEM6"/>
    <dbReference type="GeneID" id="2876778"/>
    <dbReference type="KEGG" id="ani:ANIA_01004"/>
    <dbReference type="eggNOG" id="KOG4051">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050564_2_0_1"/>
    <dbReference type="InParanoid" id="Q5BEM6"/>
    <dbReference type="OMA" id="TRIPNIW"/>
    <dbReference type="OrthoDB" id="5595141at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043189">
        <property type="term" value="C:H4/H2A histone acetyltransferase complex"/>
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        <property type="project" value="InterPro"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="InterPro" id="IPR012423">
        <property type="entry name" value="Eaf7/MRGBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13581">
        <property type="entry name" value="MRG-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13581:SF5">
        <property type="entry name" value="MRG_MORF4L-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07904">
        <property type="entry name" value="Eaf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
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        <location>
            <begin position="87"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="151"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBF88354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="222" mass="24793" checksum="A6241EE971800534" modified="2005-04-26" version="1">MHKHFRMVAISEFMKSQGYAPSHAEHTRIPGIWKKLGTLYNLPALDEREDSLITDVSDDVDGREVYCPFELPEDEYGDLMFERRLAMEGSPSPAPSGHPESRRGSTVADTDEPRSSPVPTRGRKPGRGRPAGRGTRSSRLQVKVESRQESSEIEDEDAESEEENEESEEESSDAKDESEEEDADGDTGSSPNGRSTRARTTTSRRGRRRGGGASRRGRRRQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BF36</accession>
    <accession>C8VQ26</accession>
    <name>Q5BF36_EMENI</name>
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        <recommendedName>
            <fullName evidence="6">Protein SDA1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ANIA_00844</name>
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    <organism evidence="11 12">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
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            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for 60S pre-ribosomal subunits export to the cytoplasm.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the SDA1 family.</text>
    </comment>
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        <property type="protein sequence ID" value="CBF88672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_658448.1">
        <property type="nucleotide sequence ID" value="XM_653356.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BF36"/>
    <dbReference type="FunCoup" id="Q5BF36">
        <property type="interactions" value="1102"/>
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    <dbReference type="STRING" id="227321.Q5BF36"/>
    <dbReference type="GeneID" id="2876623"/>
    <dbReference type="KEGG" id="ani:ANIA_00844"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN0844"/>
    <dbReference type="eggNOG" id="KOG2229">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009161_2_1_1"/>
    <dbReference type="InParanoid" id="Q5BF36"/>
    <dbReference type="OMA" id="AMYKTYK"/>
    <dbReference type="OrthoDB" id="2196187at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
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    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0042273">
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        <property type="project" value="EnsemblFungi"/>
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        <property type="entry name" value="ARM-type_fold"/>
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        <property type="entry name" value="Sda1"/>
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        <property type="entry name" value="SDA1_C"/>
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        <property type="entry name" value="SDA1_MD"/>
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        <property type="entry name" value="SDA1_N"/>
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    <dbReference type="PANTHER" id="PTHR12730">
        <property type="entry name" value="HSDA/SDA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12730:SF0">
        <property type="entry name" value="PROTEIN SDA1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21638">
        <property type="entry name" value="SDA1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05285">
        <property type="entry name" value="SDA1_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08158">
        <property type="entry name" value="SDA1_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SDA1 N-terminal" evidence="9">
        <location>
            <begin position="69"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="SDA1 middle" evidence="8">
        <location>
            <begin position="548"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="domain" description="SDA1 C-terminal" evidence="10">
        <location>
            <begin position="697"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="463"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="507"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="475"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="516"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="553"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="567"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="662"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="691"/>
            <end position="703"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CBF88672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="748" mass="84766" checksum="18320F10B4D02876" modified="2005-04-26" version="1">MVKRKLGALEKVEADLPNLQHKIRRDPKSYIEDFRAQHYQYESHREIFMAAPSSATDTGLISLRELIDFIAHVADCYPDITKDFGQQLIDMLSQHHQVFEPELREKIVGSLVLLRKKDLLDSTTLLQTLFPILISTPSKTLRALIFQKILMDLRSSNAKTTNHKLNRTMQTVLFNLVTSDRTSSKGLWAIKLTRELWKRQIWTDAKAVEIMKEASLAENEKVIVGGVRFFLGGDKEREEMEEESSDEEAIDLGRVKHQVGINKKTKKKARAIEKAKATVQKRERKKNQPHPLNFSALHLLYDPQGFAESLFAKHLQSSKSKLNLEQKLMVLQLVTRLVGLHKLHIMHLYSYFQKYLTPRQPSVTSFLASLAQASHDLIPPDDLEPLVQKIANEFVSEASASEVATAGLNAIREICARQPLAMNETLLQDLVMYRKSKDKGVVMGARGLLSLYRDVNPEMLKRRDRGKDASISLQHGEKKEKRFAAQEAGGIEGIELLEQWKEEERKRKRAEKGLATDDEDEENEDEDENDWTAWNVEDDEDSDDSGGWIDVQSDVEIDLSDSEDDERPAKKAKQADDKENSADSNPQAPETKPDPRKPSLATSRILTPADLAKLQELRQQAAINALVPGPKRRGATSESRHKEDPLTAAEIEGLAALSAGKKTREERIAHAKEGKTDRSEHKSVTAKRKERKEEQGKSTTNKEKARKKNFLMTLGKAKSKGKRSLVETRAVLRAHHERAKRGGRRGNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="117" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BFH7</accession>
    <accession>C8VRN8</accession>
    <name>Q5BFH7_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WD repeat protein (AFU_orthologue AFUA_1G13690)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_00703</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF88953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_658307.1">
        <property type="nucleotide sequence ID" value="XM_653215.2"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q5BFH7">
        <property type="interactions" value="62"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5BFH7"/>
    <dbReference type="GeneID" id="2876480"/>
    <dbReference type="KEGG" id="ani:ANIA_00703"/>
    <dbReference type="eggNOG" id="KOG1064">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000310_0_1_1"/>
    <dbReference type="InParanoid" id="Q5BFH7"/>
    <dbReference type="OMA" id="NSHLTLW"/>
    <dbReference type="OrthoDB" id="342131at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043291">
        <property type="term" value="C:RAVE complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052208">
        <property type="entry name" value="DmX-like/RAVE_component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022033">
        <property type="entry name" value="Rav1p_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13950:SF9">
        <property type="entry name" value="RABCONNECTIN-3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13950">
        <property type="entry name" value="RABCONNECTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12234">
        <property type="entry name" value="Rav1p_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RAVE complex protein Rav1 C-terminal" evidence="2">
        <location>
            <begin position="650"/>
            <end position="1292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1337"/>
            <end position="1373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF88953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="1373" mass="154354" checksum="302509B2BA31A670" modified="2005-04-26" version="1">MSVDLLSSSFSRPVLVESLLRFSALYDSSWQWCNLRLERNERLISPPTTPMRAVLPGRPPAKLQSFGTASWNGLRVVVYISGQALVILGGPHNLLQTIYVDDTQALQAVAIDGASGRIAVCGGPSAFVYEPYGTYGETLKWSLAFTLRYEDDEEPICTISWGSSDELLLGNSHLTLWFLHDTPRAAWREKLANPVKFAQISPDSTLIVTTGVYDRFVKVWKRLAFGADDVRFDVSYLAHPAIVTGFHWRRPLHGEQSMANVFYTLCADNKIRVWAAIDNHAPSPLQLWTQIDMNRSVQPRHATNGVGVSRRYGFIIDSRDFCSATERAVERGAGNKGNHALEHIIEVATRSPEIYVVMDGEGHMAAWALEDVGSKAQSKMNVFNILHVEGLDFSFLRGLSAEEDYAQICAFQSADPGDALSILVHHFDGRIEWYDSQVDVLFDPAPVRNRIARKASWTGHIGPVKKIIRNAFGDTLTSRTDDNKALIWRQKRRDSGSGLLRKSTLFSDEHIHRSCVIENGDFIVNLHHNGISVWDVRSFHAERIASLTFELSGKPLCVLEMLTPEKNAGVVYIAAIAADMSGIAWEVNLPLAKGHTKSQCHLKKFCTFDLGLKEDVSYFLPVDPAGPRTQLSGFFDLFSPDIALSYTATGIVHTWTARVDKDNSRIEWLLTSTVETGIANPSLASGSSIKKAALVDEDRTHLTIWDTKGAQLEFEEHFAQKDIIRDLDWTSTPDMQSVLAVGFPHKVILLTQLRYDYLDSGPSWTQIREIWIRDLTPHPIGDSCWLSSGYLAIGAGNQLFVYDNEIEATDRVVSQLRIPTRGSSTVDLFEVVSRLNGALPVFHPQFLAQCILSGKTNLVHSILMNLHRKLKFYTEGDDIDGFLEMALEDFYVDHDVPQQAVSKELHSSYADLSLEEEPTVMDEATAAILNENLARVALPQLTSQEQVRLVDTIECVATVEKHRRSMDDNAARYLLFFRQHMLRRTQGIANNDTVSWREIVWAFHSGSQDILIDLVSRQFGGKLSWKAARESGIFMWLSNSATIREQLEVVARNEYTKTEERNPIDCSLYYLALRKKNILQGLWRMAHWNREQSATQKLLANDFRESRWQTAALKNAYALLGRRRFEYAAAFFLLADHLRDAVQVCLNQVGDLQLAIAIARAYEGDNGPVLKEILETRVLPEAAMDGNRWMASWAFWMLGRRDMAVRSLISPVESLIPSDPASPETPGSISLQAKSYLSNDPALVVLYKQLREMTLQTLKGASKVSAQAEWEFVLRNARLYDRMGCDLLALDLVRHWEFLKEPPSTQLSKDGMINLVDGAIDYRKMLRRRSSLVVADMPAKPREPTSPVAPKQQPPPTMFHEPDANSLLDSFGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="104" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BFR7</accession>
    <accession>C8VS94</accession>
    <name>Q5BFR7_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">glucarate dehydratase</fullName>
            <ecNumber evidence="5">4.2.1.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ANIA_00613</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-glucarate = 5-dehydro-4-deoxy-D-glucarate + H2O</text>
            <dbReference type="Rhea" id="RHEA:14573"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30612"/>
            <dbReference type="ChEBI" id="CHEBI:42819"/>
            <dbReference type="EC" id="4.2.1.40"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate acid metabolism; D-glucarate degradation; 2,5-dioxopentanoate from D-glucarate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the mandelate racemase/muconate lactonizing enzyme family. GlucD subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.40" evidence="5"/>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF89129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_658217.1">
        <property type="nucleotide sequence ID" value="XM_653125.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BFR7"/>
    <dbReference type="STRING" id="227321.Q5BFR7"/>
    <dbReference type="GeneID" id="2876390"/>
    <dbReference type="KEGG" id="ani:ANIA_00613"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN0613"/>
    <dbReference type="eggNOG" id="ENOG502SIK1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030273_9_0_1"/>
    <dbReference type="InParanoid" id="Q5BFR7"/>
    <dbReference type="OMA" id="MQYLIPN"/>
    <dbReference type="OrthoDB" id="17395at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008872">
        <property type="term" value="F:glucarate dehydratase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042838">
        <property type="term" value="P:D-glucarate catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd03323">
        <property type="entry name" value="D-glucarate_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="entry name" value="Enolase-like C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="entry name" value="Enolase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034593">
        <property type="entry name" value="DgoD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029065">
        <property type="entry name" value="Enolase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034598">
        <property type="entry name" value="GlucD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013342">
        <property type="entry name" value="Mandelate_racemase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48080">
        <property type="entry name" value="D-GALACTONATE DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48080:SF4">
        <property type="entry name" value="GLUCARATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13378">
        <property type="entry name" value="MR_MLE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00001">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00055">
        <property type="entry name" value="glucarate_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00922">
        <property type="entry name" value="MR_MLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="Enolase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="Enolase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mandelate racemase/muconate lactonizing enzyme C-terminal" evidence="9">
        <location>
            <begin position="169"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBF89129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="424" mass="46543" checksum="A2A339943B6B3BE6" modified="2005-04-26" version="1">MAIIKDIVITPVAFHDPPLLNSVGVHEPFALRSIVEVVTETVYGLGESYGDSAHLDRLAKAAQQIKSLSLSIYDTNAIYQICVNSLAKDTTTGGDGMAGMVTTASVADKVFSPFEVACLDLQGKLAGVPVSDILGGRVRDNVQYSAYLFYKWAGHPGLPDDEYGEALTPEQLVQQAEKIIAEYGFRAIKLKGGVFSPEQEVAAIKALHAAFPGIPLRFDPNAAWTVETSKWVANELAGIVEYLEDPAPEIGGMAAVAKEASMPLATNMAVVAFDHLPPSILQKAVQVILSDHHFWGGLRKSQTLASICTIWGMRLSMHSNSHLGISLAAMTHLAAATPNLDYACDTHWPWKRRDEDVIVDPERALRWVNGGIEVPRAPGLGIELDRGQLWRLHRQYLECGIRERDDTSYMRRFEPKFDASIPRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="123" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BGQ9</accession>
    <accession>C8VUD3</accession>
    <name>Q5BGQ9_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Deoxyuridine 5'-triphosphate nucleotidohydrolase</fullName>
            <shortName evidence="10">dUTPase</shortName>
            <ecNumber evidence="10">3.6.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">dUTP pyrophosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">ANIA_00271</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Involved in nucleotide metabolism via production of dUMP, the immediate precursor of thymidine nucleotides, and decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.</text>
    </comment>
    <comment type="function">
        <text evidence="2">This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>dUTP + H2O = dUMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10248"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61555"/>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <dbReference type="EC" id="3.6.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 10">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the dUTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.23" evidence="10"/>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF89841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_657875.1">
        <property type="nucleotide sequence ID" value="XM_652783.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BGQ9"/>
    <dbReference type="FunCoup" id="Q5BGQ9">
        <property type="interactions" value="1123"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5BGQ9"/>
    <dbReference type="GeneID" id="2876048"/>
    <dbReference type="KEGG" id="ani:ANIA_00271"/>
    <dbReference type="eggNOG" id="KOG3370">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068508_2_0_1"/>
    <dbReference type="InParanoid" id="Q5BGQ9"/>
    <dbReference type="OMA" id="RSGMGHK"/>
    <dbReference type="OrthoDB" id="419889at2759"/>
    <dbReference type="UniPathway" id="UPA00610">
        <property type="reaction ID" value="UER00666"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004170">
        <property type="term" value="F:dUTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006226">
        <property type="term" value="P:dUMP biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046081">
        <property type="term" value="P:dUTP catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd07557">
        <property type="entry name" value="trimeric_dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.40.10:FF:000004">
        <property type="entry name" value="Deoxyuridine triphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008181">
        <property type="entry name" value="dUTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029054">
        <property type="entry name" value="dUTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036157">
        <property type="entry name" value="dUTPase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033704">
        <property type="entry name" value="dUTPase_trimeric"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00576">
        <property type="entry name" value="dut"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001862">
        <property type="entry name" value="PRK00601.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11241">
        <property type="entry name" value="DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11241:SF0">
        <property type="entry name" value="DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00692">
        <property type="entry name" value="dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51283">
        <property type="entry name" value="dUTPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="dUTPase-like" evidence="12">
        <location>
            <begin position="79"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CBF89841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="208" mass="21487" checksum="FBC18AB3A9A3C17C" modified="2005-04-26" version="1">MTKEATPPPRETTTTSTTHEPPSLPASPLAKRPKPSDTTGTSASAIKMVSTDSTAPVATAPTASTPTPALLVKKLTDTARAPTRGSAFAAGYDLYAAKETIIPAKGKGLVDTGLAVAVPEGTYGRVAPRSGLASKHFIDVGAGVIDADYRGEVKVLLFNFSDVDFTIKEGDRVAQLVLERIYTPEVAVVEELAESVRGAGGFGSTGTN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-07-24" modified="2026-01-28" version="106" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BGR9</accession>
    <accession>C8VUJ3</accession>
    <name>SEC23_EMENI</name>
    <protein>
        <recommendedName>
            <fullName>Protein transport protein sec23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">sec23</name>
        <name type="ORF">AN0261</name>
    </gene>
    <organism>
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">The COPII coat is composed of at least 5 proteins: the sec23/24 complex, the sec13/31 complex, and the protein sar1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">COPII-coated vesicle membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SEC23/SEC24 family. SEC23 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AACD01000005">
        <property type="protein sequence ID" value="EAA66134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF89861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_657865.1">
        <property type="nucleotide sequence ID" value="XM_652773.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BGR9"/>
    <dbReference type="SMR" id="Q5BGR9"/>
    <dbReference type="FunCoup" id="Q5BGR9">
        <property type="interactions" value="1015"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5BGR9"/>
    <dbReference type="EnsemblFungi" id="CBF89861">
        <property type="protein sequence ID" value="CBF89861"/>
        <property type="gene ID" value="ANIA_00261"/>
    </dbReference>
    <dbReference type="GeneID" id="2876036"/>
    <dbReference type="KEGG" id="ani:ANIA_00261"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN0261"/>
    <dbReference type="eggNOG" id="KOG1986">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008658_3_0_1"/>
    <dbReference type="InParanoid" id="Q5BGR9"/>
    <dbReference type="OMA" id="FPPHYAE"/>
    <dbReference type="OrthoDB" id="10256289at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01478">
        <property type="entry name" value="Sec23-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11287">
        <property type="entry name" value="Sec23_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.730:FF:000001">
        <property type="entry name" value="Protein transport protein SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.380:FF:000001">
        <property type="entry name" value="Protein transport protein SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000006">
        <property type="entry name" value="Protein transport protein SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000008">
        <property type="entry name" value="Protein transport protein SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1670">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.730">
        <property type="entry name" value="Sec23/Sec24 helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012990">
        <property type="entry name" value="Beta-sandwich_Sec23_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007123">
        <property type="entry name" value="Gelsolin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036180">
        <property type="entry name" value="Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037364">
        <property type="entry name" value="Sec23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006900">
        <property type="entry name" value="Sec23/24_helical_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036175">
        <property type="entry name" value="Sec23/24_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006896">
        <property type="entry name" value="Sec23/24_trunk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037550">
        <property type="entry name" value="Sec23_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006895">
        <property type="entry name" value="Znf_Sec23_Sec24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036174">
        <property type="entry name" value="Znf_Sec23_Sec24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11141">
        <property type="entry name" value="PROTEIN TRANSPORT PROTEIN SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11141:SF0">
        <property type="entry name" value="PROTEIN TRANSPORT PROTEIN SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00626">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08033">
        <property type="entry name" value="Sec23_BS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04815">
        <property type="entry name" value="Sec23_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04811">
        <property type="entry name" value="Sec23_trunk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04810">
        <property type="entry name" value="zf-Sec23_Sec24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82754">
        <property type="entry name" value="C-terminal, gelsolin-like domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81811">
        <property type="entry name" value="Helical domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82919">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword id="KW-0931">ER-Golgi transport</keyword>
    <keyword id="KW-0333">Golgi apparatus</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0653">Protein transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000295462" description="Protein transport protein sec23">
        <location>
            <begin position="1"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="771" mass="85702" checksum="0C50FF108A87DC95" modified="2005-04-26" version="1">MDYEGLKDQWSDVEDRDGIRLSWNTFPSSRMEASRLVVPIGAIYTPLKERPDAPLLQYEPVTCKAPCRAVLNPYANVDVRARIWICPFCLMRNPLPPHYKDITESTIPPELHPLSTTIEYQLARPAPAPPIFVFVVDTCQEDDSLKAVKDSLILSLSLLPPNALVGLITFGTMAQVHELGYTECAKSYVFRGSKDYNAKQVQEMLGLASGIRPNMPNMPQQPVRPPLGAAARFLLPVQQAEFQITNMLEQLQRDPWPVANDKRPLRCTGVALNVAVGLLESSFQNAGAHIMLFTSGPATEGPGLVVSPELKEPIRSHHDIDRDNIKYYKKALKFYDALAKRAANNGHVVDLFAGCLDQVGLLEMKNLANYTGGHILLTDSFTSSQFKQSFIRVFDKDANDNLLMGFNASLEVLTTKELKVTGLIGHAVSLNKKSSSVGETECGIGNTCAWKMCGIDPSSSYGIYFEIANQGGPAAVQPGPQRGMMQFLTYYQHSSGHFHLRVTTVARNLSGPAGDPTLAQSFDQEAAAVLMARIGVFKAEVDDGPDVLRWVDRMLIRLCSRFADYRKDDPTSFRLEKNFTLYPQFMFHLRRSQFLQVFNNSPDETAFYRHVLNHEDVGDSLIMIQPTLDSYSLEHEGSLPVLLDSASIQPTHILLLDTFFHILIFHGETIAEWRKAGYQDQEGYENLKALLDLPKEDARELISERFPLPRFIVCDAGGSQARFLLSKLNPSTTHTTGGYGGGVSSQTIFTDDVSLQTFMDHLMKLAVSGTS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-16" modified="2026-01-28" version="109" xmlns="https://uniprot.org/uniprot">
    <accession>Q870L3</accession>
    <accession>C8VBG2</accession>
    <accession>Q5AW45</accession>
    <name>MIRC_EMENI</name>
    <protein>
        <recommendedName>
            <fullName>Siderophore iron transporter mirC</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Major facilitator iron-regulated transporter C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">mirC</name>
        <name type="ORF">AN7485</name>
    </gene>
    <organism>
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Biochem. J." volume="371" first="505" last="513">
            <title>Characterization of the Aspergillus nidulans transporters for the siderophores enterobactin and triacetylfusarinine C.</title>
            <authorList>
                <person name="Haas H."/>
                <person name="Schoeser M."/>
                <person name="Lesuisse E."/>
                <person name="Ernst J.F."/>
                <person name="Parson W."/>
                <person name="Abt B."/>
                <person name="Winkelmann G."/>
                <person name="Oberegger H."/>
            </authorList>
            <dbReference type="PubMed" id="12487628"/>
            <dbReference type="DOI" id="10.1042/BJ20021685"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AY135152">
        <property type="protein sequence ID" value="AAN08046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AACD01000129">
        <property type="protein sequence ID" value="EAA62065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF79472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_680754.1">
        <property type="nucleotide sequence ID" value="XM_675662.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q870L3"/>
    <dbReference type="SMR" id="Q870L3"/>
    <dbReference type="STRING" id="227321.Q870L3"/>
    <dbReference type="EnsemblFungi" id="CBF79472">
        <property type="protein sequence ID" value="CBF79472"/>
        <property type="gene ID" value="ANIA_07485"/>
    </dbReference>
    <dbReference type="GeneID" id="2869709"/>
    <dbReference type="KEGG" id="ani:ANIA_07485"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN7485"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012970_2_0_1"/>
    <dbReference type="InParanoid" id="Q870L3"/>
    <dbReference type="OMA" id="PWKGKGL"/>
    <dbReference type="OrthoDB" id="2241241at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015343">
        <property type="term" value="F:siderophore-iron transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010106">
        <property type="term" value="P:cellular response to iron ion starvation"/>
        <property type="evidence" value="ECO:0000270"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd17322">
        <property type="entry name" value="MFS_ARN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000510">
        <property type="entry name" value="Siderophore iron transporter mirC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000533">
        <property type="entry name" value="Siderophore iron transporter mirC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF87">
        <property type="entry name" value="SIDEROPHORE IRON TRANSPORTER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0406">Ion transport</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0410">Iron transport</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000084861" description="Siderophore iron transporter mirC">
        <location>
            <begin position="1"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="279"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="311"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="349"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="388"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="417"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="446"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="481"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="557"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="584"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="584"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="607" mass="66288" checksum="5826FFDD36B1A73A" modified="2003-06-01" version="1">MPLLEPSATAYGTFGDMRPDTEDEGERLLTDGYVSDDDGSAVTSVDSVQEGVRKIEAINITWTTRSLVIAYISIFLMAFCTSLEGQTIMSLSAYATSAFSKHSLISTVLVVQNVVNAVIKPPMAKIADVFGRFEAFCVSILIYVLGYIQMAASTNVQTYASAQIFYAAGSTGLQILQQVFIADSSSLLNRALLALLPELPFLVTVWIGPTIADVVLENSSWRWGYGMWSIILPASFLPLALSLLLNQRKAKRLNLIKERPHHRRGFVAAVRRTWYDLDIFGLALLSAAVTLILVPLTLAANTKNGWKSNSIVAMIVIGVVCLILLPFWETSKKLAPKPLLSLHLLKQRTALAGCCLAFFYFMAFYFSVQPYLYSYLQVVQGYDVATAGRVTQTFAFTSTIAAFGVSILIKYTRRYRVYVTLGCVIYMTGLLLMLLYRKEGSSPLQVLGTQVIVGMGGGLLNVPVQLGVQASASHQEVAAATAMFLTSMEMGGAVGAAISGAVWTHNIPRKLNLYLPDEYKSEAGAIFGKLTKALSYEMGTPVRSAINRSYQETMNKLLVLALLATLPLIPLSLLMSNYKLDKMSESSDHDDASPRNGLGPGERAKRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>C8V029</accession>
    <name>C8V029_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ANIA_10744</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF70751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V029"/>
    <dbReference type="HOGENOM" id="CLU_3419417_0_0_1"/>
    <dbReference type="InParanoid" id="C8V029"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF70751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="25" mass="2927" checksum="36BF8C8C671F0645" modified="2009-11-03" version="1">MGRQKLKTQIEISLLDPIQDAYPRL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2020-04-22" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C8V1D1</accession>
    <name>BIOF_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">8-amino-7-oxononanoate synthase</fullName>
            <shortName evidence="3">AONS</shortName>
            <ecNumber evidence="5">2.3.1.47</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">7-keto-8-amino-pelargonic acid synthase</fullName>
            <shortName evidence="3">7-KAP synthase</shortName>
            <shortName evidence="3">KAPA synthase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">8-amino-7-ketopelargonate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">bioF</name>
        <name type="ORF">ANIA_06645</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2011" name="Fungal Genet. Biol." volume="48" first="208" last="215">
            <title>Characterization of the Aspergillus nidulans biotin biosynthetic gene cluster and use of the bioDA gene as a new transformation marker.</title>
            <authorList>
                <person name="Magliano P."/>
                <person name="Flipphi M."/>
                <person name="Sanglard D."/>
                <person name="Poirier Y."/>
            </authorList>
            <dbReference type="PubMed" id="20713166"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2010.08.004"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INDUCTION</scope>
        <scope>PATHWAY</scope>
    </reference>
    <comment type="function">
        <text evidence="1 2">8-amino-7-oxononanoate synthase; part of the cluster involved in the biosynthesis of biotin (also known as vitamin B8 or vitamin H), a water-soluble vitamin that functions as a prosthetic group of many carboxylases, such as acetyl-CoA carboxylase and pyruvate carboxylase (PubMed:20713166). Catalyzes the decarboxylative condensation of pimeloyl-[acyl-carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>6-carboxyhexanoyl-[ACP] + L-alanine + H(+) = (8S)-8-amino-7-oxononanoate + holo-[ACP] + CO2</text>
            <dbReference type="Rhea" id="RHEA:42288"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9955"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78846"/>
            <dbReference type="ChEBI" id="CHEBI:149468"/>
            <dbReference type="EC" id="2.3.1.47"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; biotin biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="induction">
        <text evidence="2">Expression is increased when transferring biotin auxotrophic mutant mycelia from biotin-supplemented medium to biotin-deficient medium.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.47" evidence="5"/>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF71163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V1D1"/>
    <dbReference type="SMR" id="C8V1D1"/>
    <dbReference type="STRING" id="227321.C8V1D1"/>
    <dbReference type="EnsemblFungi" id="CBF71163">
        <property type="protein sequence ID" value="CBF71163"/>
        <property type="gene ID" value="ANIA_06645"/>
    </dbReference>
    <dbReference type="GeneID" id="2870398"/>
    <dbReference type="KEGG" id="ani:ANIA_06645"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN6645"/>
    <dbReference type="eggNOG" id="KOG1360">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015846_3_0_1"/>
    <dbReference type="InParanoid" id="C8V1D1"/>
    <dbReference type="OMA" id="GTHEYCD"/>
    <dbReference type="OrthoDB" id="2382073at2759"/>
    <dbReference type="UniPathway" id="UPA00078"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008710">
        <property type="term" value="F:8-amino-7-oxononanoate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050087">
        <property type="entry name" value="AON_synthase_class-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693:SF77">
        <property type="entry name" value="8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693">
        <property type="entry name" value="CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-0093">Biotin biosynthesis</keyword>
    <keyword id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000449414" description="8-amino-7-oxononanoate synthase">
        <location>
            <begin position="1"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="106"/>
            <end position="107"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="370"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="1">
        <location>
            <position position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="B7LC58"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="20713166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="3">
        <source>
            <dbReference type="PubMed" id="20713166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <evidence type="ECO:0000305" key="5">
        <source>
            <dbReference type="PubMed" id="20713166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBF71163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="412" mass="45580" checksum="F24A828DD0587550" modified="2009-11-03" version="1">MGDSPKCLRDSLREALRRREDKLCRRKLTILPSSSVDFSSNDFLSLSTSPAYRARFLDILQQAPPLHPFASGGSRLLDGNSAYAEELENFIAAFHNAPSGLLFNSGYDANVGVFSSIPQPGDLIVYDELIHASAHEGMRLSRAGKRIKFPHSSPDGLRAVLQAEITADPRLLQGRRNVFIAFESVYSMDGDVAPIREFVEIVDQLLPYGNGYFLVDEAHATGVFGPRGSGVVQELGLEDRMFVRVHTFGKALASHGAIVLCCADTRDYLINYARSLIYTTALGFPFLASIRAAYELLVEGKTEQLQHKLGQLIAHFRTGLDNLNHKDSSTFEVEHFTNSPIFSLRSSVPRVLASVCQEQGYTVRAIMPPTVPAGKERVRVCLHAGNTVEEVDGLLETIATWLQRMEKQKARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C8V1L4</accession>
    <name>C8V1L4_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Small ribosomal subunit protein uS15 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ANIA_06679</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS15 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF71234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467141.1">
        <property type="nucleotide sequence ID" value="XM_050613380.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V1L4"/>
    <dbReference type="FunCoup" id="C8V1L4">
        <property type="interactions" value="911"/>
    </dbReference>
    <dbReference type="STRING" id="227321.C8V1L4"/>
    <dbReference type="GeneID" id="2870467"/>
    <dbReference type="KEGG" id="ani:ANIA_06679"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN6679"/>
    <dbReference type="eggNOG" id="KOG0400">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090139_2_0_1"/>
    <dbReference type="InParanoid" id="C8V1L4"/>
    <dbReference type="OMA" id="MHTRRKG"/>
    <dbReference type="OrthoDB" id="623277at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070181">
        <property type="term" value="F:small ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00353">
        <property type="entry name" value="Ribosomal_S15p_S13e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.10:FF:000003">
        <property type="entry name" value="40S ribosomal protein S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.860.130:FF:000001">
        <property type="entry name" value="40S ribosomal protein S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.10">
        <property type="entry name" value="S15/NS1, RNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01343_A">
        <property type="entry name" value="Ribosomal_uS15_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000589">
        <property type="entry name" value="Ribosomal_uS15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023029">
        <property type="entry name" value="Ribosomal_uS15_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012606">
        <property type="entry name" value="Ribosomal_uS15_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009068">
        <property type="entry name" value="uS15_NS1_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006331">
        <property type="entry name" value="PRK08561.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11885">
        <property type="entry name" value="RIBOSOMAL PROTEIN S15P/S13E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11885:SF6">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08069">
        <property type="entry name" value="Ribosomal_S13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00312">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01386">
        <property type="entry name" value="Ribosomal_S13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01387">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47060">
        <property type="entry name" value="S15/NS1 RNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00362">
        <property type="entry name" value="RIBOSOMAL_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS15 N-terminal" evidence="5">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBF71234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="151" mass="16843" checksum="3A34E1A70D8068C2" modified="2009-11-03" version="1">MGRLHSKGKGIASSALPYSRTPAPWVKITPEQVVDHICKLARKGASPSQIGVVLRDSHGVAQVKTVTGNKILRILKSNGLAPEIPEDLYHLIKKAVAVRKHLERNRKDKDSKFRLILIESRIHRLSRYYKTVGVLPPTWKYESATASTMVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>C8V363</accession>
    <name>C8V363_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ANIA_11534</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF71768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467200.1">
        <property type="nucleotide sequence ID" value="XM_050611147.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V363"/>
    <dbReference type="GeneID" id="74897106"/>
    <dbReference type="KEGG" id="ani:ANIA_11534"/>
    <dbReference type="HOGENOM" id="CLU_2922615_0_0_1"/>
    <dbReference type="InParanoid" id="C8V363"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF71768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="61" mass="6543" checksum="CFA35D2437025E5E" modified="2009-11-03" version="1">MPTSRPTTIAWIARVTAEVGPTPATYANQHAKCLLDQPLPGICLILASRDGRCLSIAQCYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>C8V3Z3</accession>
    <name>C8V3Z3_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">General transcription and DNA repair factor IIH</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">ANIA_04283</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="17">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module TFIIK controls the initiation of transcription.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the GTF2H2 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF74326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467312.1">
        <property type="nucleotide sequence ID" value="XM_050611267.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V3Z3"/>
    <dbReference type="FunCoup" id="C8V3Z3">
        <property type="interactions" value="1010"/>
    </dbReference>
    <dbReference type="STRING" id="227321.C8V3Z3"/>
    <dbReference type="GeneID" id="2873708"/>
    <dbReference type="KEGG" id="ani:ANIA_04283"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN4283"/>
    <dbReference type="eggNOG" id="KOG2807">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028556_2_0_1"/>
    <dbReference type="InParanoid" id="C8V3Z3"/>
    <dbReference type="OMA" id="INWVEVP"/>
    <dbReference type="OrthoDB" id="284275at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01453">
        <property type="entry name" value="vWA_transcription_factor_IIH_type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000477">
        <property type="entry name" value="General transcription and DNA repair factor IIH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000015">
        <property type="entry name" value="General transcription factor IIH subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007198">
        <property type="entry name" value="Ssl1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004595">
        <property type="entry name" value="TFIIH_C1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012170">
        <property type="entry name" value="TFIIH_SSL1/p44"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00622">
        <property type="entry name" value="ssl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12695">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12695:SF2">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07975">
        <property type="entry name" value="C1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04056">
        <property type="entry name" value="Ssl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015919">
        <property type="entry name" value="TFIIH_SSL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01047">
        <property type="entry name" value="C1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="8 12" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="VWFA" evidence="15">
        <location>
            <begin position="91"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="13">
        <location>
            <begin position="316"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR015919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR015919-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CBF74326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="455" mass="50256" checksum="8C88925B531444A0" modified="2009-11-03" version="1">MADSDDEYIGGLSGDEGDDDIIRETRGAVGQAPKRRKQKGGAEFELARTWETLVEGADGTISSTVGGLLEASKRKRLLKDTTPLQRGIIRHIILILDLSQSMMEKDLRPTRYLLTLRYAQEFVREFFEQNPISQVGVIGLRDGLALRISDMSGNPTEHISAIQDLRSQDPKGLPSLQNGLEMARGALFHTPSHGTREIFIVFGSLLSSDPGDIHQTITTLIDDKIRVGIVGLAAQVAICRELCSRTNGGDDTYYGVALNEQHFRELMLAVTTPPATYSQKQSASSLLMMGFPSRTIESFPSLCACHSNPTPGGYLCSRCNSKVCGLPAECPSCGLTLILSTHLARSYHHLFPLMNWVEVSWERAHRSTTCFACGIAFPTIPPKEQWQATQNLAKGMSVSSRYECTVCENHFCIDCDLFAHEVVHNCPGCQSRVVRHPQDDIPRVQESVDQMDTSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>C8V4S5</accession>
    <name>C8V4S5_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ANIA_11399</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF75946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467539.1">
        <property type="nucleotide sequence ID" value="XM_050611516.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V4S5"/>
    <dbReference type="GeneID" id="74896992"/>
    <dbReference type="KEGG" id="ani:ANIA_11399"/>
    <dbReference type="HOGENOM" id="CLU_3410659_0_0_1"/>
    <dbReference type="InParanoid" id="C8V4S5"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF75946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="29" mass="3512" checksum="6BD28E69118187E8" modified="2009-11-03" version="1">MALSKEDLRYKKLERLQKFAEMDAIKERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>C8V6C0</accession>
    <name>C8V6C0_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Multidrug efflux transporter (Eurofung)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ANIA_03888</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF75163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_661492.2">
        <property type="nucleotide sequence ID" value="XM_656400.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V6C0"/>
    <dbReference type="FunCoup" id="C8V6C0">
        <property type="interactions" value="39"/>
    </dbReference>
    <dbReference type="GeneID" id="2873302"/>
    <dbReference type="KEGG" id="ani:ANIA_03888"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN3888"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_22_3_1"/>
    <dbReference type="InParanoid" id="C8V6C0"/>
    <dbReference type="OMA" id="TATITFM"/>
    <dbReference type="OrthoDB" id="6770063at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015802">
        <property type="term" value="P:basic amino acid transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000670">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000672">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF81">
        <property type="entry name" value="VACUOLAR BASIC AMINO ACID TRANSPORTER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="204"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="273"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="315"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="350"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="376"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="407"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="442"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="512"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="49"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBF75163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="542" mass="57954" checksum="D3D2411B9F6A0ECA" modified="2009-11-03" version="1">MSYGTIASVEDPPSADLAQEHEQDDEHAQEDEPLLPAVDWKPPKGFLWIEVAIFANVFLSGFDGTITASTYALISSEFKAANTSSWLTTSYLITSTAFQPLYGRFSDIFGRRACFFTSTISFLLGCLGCAVAQDVVFLNLMRALTGVGGGGLMTMATIINSDMIPFHRRGMYQAAQNVLHGFGSICGASLGGSIANTIGWRWCFLLQVPVSVFALAIGRIVIPMPQKPPTGVGWSVWKQVDLTGALLLILGLSVQLVGLSLGGNELPWSNGWVVSSLLGSLVLLGGFIVVEAKTSAIPVIPLRMLKGLLPVSTQIANVCVGMAAYAFLFNLPLFFQIVLLDSASKAGARLVIPSLATPVGGLLSGIVMSHYGKLSYLMRAGAMLMFLGNLLVMILDFEDSAWKYFVYVIPANLGQGVVYPAILFTVLAAFGHEDHAVSASTVYLIRSLGTVYGVAITSAIVQNELVRSLPGALRGVPNKWKVIDEIRHSVSAIYTLEPEIQLAARHVYYGGIRMAFAVSAGFGAVAVVAALFARGRGLKRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>C8V8W8</accession>
    <name>C8V8W8_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ilp is an apoptosis inhibitor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_04375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF77655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467740.1">
        <property type="nucleotide sequence ID" value="XM_050611749.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V8W8"/>
    <dbReference type="GeneID" id="2872167"/>
    <dbReference type="KEGG" id="ani:ANIA_04375"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN4375"/>
    <dbReference type="eggNOG" id="ENOG502S2F8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079969_0_0_1"/>
    <dbReference type="InParanoid" id="C8V8W8"/>
    <dbReference type="OMA" id="FEWYPHY"/>
    <dbReference type="OrthoDB" id="5335812at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053267">
        <property type="entry name" value="Verrucosidin_biosynth-assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42087">
        <property type="entry name" value="ILP IS AN APOPTOSIS INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42087:SF1">
        <property type="entry name" value="ILP IS AN APOPTOSIS INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF77655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="250" mass="27727" checksum="9FB10F2F1CBBE19D" modified="2009-11-03" version="1">MLRRILPDSFYPPTHSKKQAARATGPPSASPDPDTTAMLGLSELPQNANGENFDILEWYPHYQNCQRYFLDHAQHSSPVQAVSAYVNILLPFQRQPYPVFSATARTPSSTDAELTSGSSSTSNTPPPVSLLPYVRRLVATGMDYPGMLHGFFGDDWQSGIGPLHEKERCNYLLAARSGGWAVVKSEYDISPHETIPFLRPLQGPLEEEVVTAYRSWSEWLLLRDWEIGPRAPDGLQDSSSQSSPPPSAQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>C8VAM8</accession>
    <name>C8VAM8_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-dependent RNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ANIA_04790</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RdRP family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.48" evidence="1"/>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF76776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_662394.2">
        <property type="nucleotide sequence ID" value="XM_657302.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VAM8"/>
    <dbReference type="STRING" id="227321.C8VAM8"/>
    <dbReference type="GeneID" id="2872588"/>
    <dbReference type="KEGG" id="ani:ANIA_04790"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN4790"/>
    <dbReference type="eggNOG" id="KOG0988">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_330100_0_0_1"/>
    <dbReference type="InParanoid" id="C8VAM8"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031380">
        <property type="term" value="C:nuclear RNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003968">
        <property type="term" value="F:RNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007855">
        <property type="entry name" value="RDRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057596">
        <property type="entry name" value="RDRP_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079">
        <property type="entry name" value="RNA-DEPENDENT RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079:SF55">
        <property type="entry name" value="RNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05183">
        <property type="entry name" value="RdRP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 4" id="KW-0696">RNA-directed RNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RDRP core" evidence="3">
        <location>
            <begin position="247"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="RDRP core" evidence="3">
        <location>
            <begin position="318"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="RDRP core" evidence="3">
        <location>
            <begin position="488"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBF76776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="869" mass="98446" checksum="DCE68608BDEFA434" modified="2009-11-03" version="1">MSPAPRNRSKPNLPMMPPSKHRSRPVPQPADQQLILAPWRAWESIAVHLSNVTAGVRTLDLWRAFKDEGNVRSIDIFENFQGNRTTRARIRLIPNPEQTSPGTDFWKSAFRRITLHNGKSIYISMSLGKKPPNWEVSAQSKGGSVSRQKLRLRFRLRDTTKEWPTPICKWIDLNPKASKTSSTAVQDPFDTSHIHLPFAVRYLLEARKLFEHVTLQKKTYYNPDGSFRHKSCQEGKSRKNTVLLLPDISNCVIRRYANLADNFLRVRFTDAKHIGRIHATVDNTMDEVLTRIKRALANGITIGSTRYEFLAFGNSSSCFSTTRAISGCTAHVKKIDDIEGNGYIFSDGVGRISKFLAQIVKSELKIKTPTKEPPSAYQFRLVGCKGMLIVFPQARPQEVHIRKSQFKFAALSQGLEIIRWSQFTVASLNRQLILVLSTLGITDKVFHLKLKTMLRNLDEAMESDPKAAHLLRKYVDPNQVTLTIYLPKNGEKYEIIEGICILARNPSLHPGGIRVVRAVNAPGLHHLKDIVVLPRTGDRDIASMCSGSDLDGDDFLVIWDQDLLPDDWFRSFQLRQLPTRISHGVITLMMVSTKQNAYGSLSYTQKPSTTTRQLYDAVGRIDFGPNIEMDFDKRILNCNVEVHDAIYGFARRLKDEYDIAIRRITAQHEIKTEFEVWLTYYKFHEDIGAMSLALRENFKKRAFEKVGGRTFDALAPLAVAMYRVTYQEMATALAKHPTTLSTDLQCNRPAQHQIGEAELGTCLKKCDTTKQDHQALGPPKYHPDDDPFGLGLRDDADAATIASNNLPSSDCNVDRWKISFGFGPLNVLSAQSKLLYMPRLRLKKGLCWILTVTLPRAGGKLTLRRPRRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>C8VB99</accession>
    <name>C8VB99_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_10971</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF79358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_680696.2">
        <property type="nucleotide sequence ID" value="XM_675604.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VB99"/>
    <dbReference type="GeneID" id="2869396"/>
    <dbReference type="KEGG" id="ani:ANIA_10971"/>
    <dbReference type="eggNOG" id="ENOG502SIQW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022827_1_0_1"/>
    <dbReference type="InParanoid" id="C8VB99"/>
    <dbReference type="OMA" id="NMPVQAK"/>
    <dbReference type="OrthoDB" id="20105at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="215"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="251"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="329"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="40"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="125"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="255"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF79358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="474" mass="53266" checksum="F583B7F062118118" modified="2009-11-03" version="1">MNFLANDLEHTLEDDYRMALTTAHLEKEFYHVHAHTVQVLETERARVQRMEQLLLRIENENLQLQLNQAGLDLNQAKEAESGIRLELDRAIRELDLLQHVAHASSREIDNLRHELASLSAIASDTQKLQAEKVRLTKEVSSIRSEVDELRSQNTSANALLAENQAITRQLNATKIQLENEKRAHERTLAKQAQQKEDVGALTTKLEVARQELELARRHGHHNTRQKNSTPPVSGENRGADKNAVVLKDRHLEDTPVQQQEEWGTTTTIKVPTERAAESYPRNFTTRLHPELTIATPGAVCAQTQQKPFSTLPGDKSSFSITPFLNRTTELDDSSMSSDDELNEASNTGKDGHGANTITSPKQLKSPIPKQPSKLAKQAPAKAAVKDDTRNGQKQMIPDSPDVDRSNQSSLSRPVGQKQAPSKKRKLGLQRDRNLFDEDEDDNTSQEIRKPGRKLVGRTVHLRLPVNIAHSPNFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>C8VD16</accession>
    <name>C8VD16_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">GTP binding protein (SPG1), putative (AFU_orthologue AFUA_6G10330)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ANIA_07206</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF78868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="XP_050467883.1">
        <property type="nucleotide sequence ID" value="XM_050611912.1"/>
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    <dbReference type="AlphaFoldDB" id="C8VD16"/>
    <dbReference type="FunCoup" id="C8VD16">
        <property type="interactions" value="525"/>
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    <dbReference type="STRING" id="227321.C8VD16"/>
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    <dbReference type="KEGG" id="ani:ANIA_07206"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN7206"/>
    <dbReference type="eggNOG" id="KOG1673">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_041217_0_0_1"/>
    <dbReference type="InParanoid" id="C8VD16"/>
    <dbReference type="OMA" id="FDLNCTI"/>
    <dbReference type="OrthoDB" id="6585768at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
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    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
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        <property type="term" value="F:GTP binding"/>
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    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
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        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:positive regulation of mitotic division septum assembly"/>
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        <property type="entry name" value="Spg1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Septum-promoting GTP-binding protein 1"/>
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    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
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        <property type="entry name" value="Small_GTP-bd"/>
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    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
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    <dbReference type="InterPro" id="IPR017231">
        <property type="entry name" value="Small_GTPase_Tem1/Spg1"/>
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    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037527">
        <property type="entry name" value="Small_GTPase_Tem1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="42"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="70"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="109"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBF78868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="314" mass="35289" checksum="CE5A3754E5544F04" modified="2009-11-03" version="1">MDPAQPPVAEAPVPEAEPQHQDQYQENQPEHQHHQTELDQPDQMSQGLSHMSETETPTIVPTAASEEPTLPSTSYHNGYSSDSRAHYEYHTPTQDPQPQPPTSSRPSSGLSGTQKQPAQTTKNSVVIKVGMVGDAQIGKTSLMVKYVEGSWDEDYIQTLGVNFMEKTISIRNTEITFSIWDLGGQREFVNMLPLVCNDAVAILFMFDLTRKSTLNSIKEWYRQGRGFNKTAIPFLVGTKYDHFVNFPREDQEEISIQAKRFAKAMKASLIFSSTSHSINVQKIFKIVLAKAFDLKCTIPEIENIGEPLLLYKNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>C8VDG7</accession>
    <name>C8VDG7_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Polyubiquitin binding protein (Doa1/Ufd3), putative (AFU_orthologue AFUA_5G08370)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ANIA_07704</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF79941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468027.1">
        <property type="nucleotide sequence ID" value="XM_050612069.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VDG7"/>
    <dbReference type="FunCoup" id="C8VDG7">
        <property type="interactions" value="1365"/>
    </dbReference>
    <dbReference type="STRING" id="227321.C8VDG7"/>
    <dbReference type="GeneID" id="2869697"/>
    <dbReference type="KEGG" id="ani:ANIA_07704"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN7704"/>
    <dbReference type="eggNOG" id="KOG0301">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011791_2_0_1"/>
    <dbReference type="InParanoid" id="C8VDG7"/>
    <dbReference type="OMA" id="DKCIYYW"/>
    <dbReference type="OrthoDB" id="10265988at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010992">
        <property type="term" value="P:ubiquitin recycling"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.870:FF:000003">
        <property type="entry name" value="Polyubiquitin binding (Doa1 Ufd3) protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000377">
        <property type="entry name" value="Polyubiquitin binding protein (Doa1/Ufd3)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000236">
        <property type="entry name" value="Polyubiquitin binding protein (Doa1/Ufd3)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.870">
        <property type="entry name" value="PFU (PLAA family ubiquitin binding), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015155">
        <property type="entry name" value="PFU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038122">
        <property type="entry name" value="PFU_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013535">
        <property type="entry name" value="PUL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19849">
        <property type="entry name" value="PHOSPHOLIPASE A-2-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19849:SF0">
        <property type="entry name" value="PHOSPHOLIPASE A-2-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09070">
        <property type="entry name" value="PFU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08324">
        <property type="entry name" value="PUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51394">
        <property type="entry name" value="PFU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51396">
        <property type="entry name" value="PUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="36"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="131"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="258"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="PFU" evidence="7">
        <location>
            <begin position="397"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="PUL" evidence="8">
        <location>
            <begin position="526"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="486"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="486"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBF79941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="811" mass="87875" checksum="93401E4A93F96A93" modified="2009-11-03" version="1">MARSFVCHVSDSITTLLFRSLSFVYCMPEFKISAALEGHGDDVRAVAFPNSKAVFSASRDATVRLWKLVSSPPPTFDYTIICHGSAFINALAYYPPTPDFPEGLVFSGGQDTIIEARQPGKTSNDNADAMLLGHAHTVCSLDVCPEGEWIVSGSWDSTARLWRIGKWESEVVLEDHQGSVWAVLAYDKNTIITGCADNIIRIFNSSGKLLKRIKDSRDVVRALCKLPPTHPTGANFVSASNDGVIRLFTLQGDLVGELHGHESFIYSLAVLPTGELVSSGEDRTVRIWNETQCVQTITHPAISVWGVAVCPENGDIVTGASDRVTRVFTRAPERQASAEVLQQFETAVRESAIPAQQVGKINKEKLPGPEFLQQKSGTKDGQVQMIREANGSVTAHTWSAALGRWESVGTVVDSAGSSGRKTEYLGQDYDFVFDVDVEDGKPPLKLPYNLSQNPYEAATKFIGDNELPMSYLDQVAQFIVQNTQGATIGQPSQETAGGPDPWGQDRRYRPGDAPAQSTAIPESRPKVLPQKTYLSIKSANLKVISKKLNELNGKLVSEGSKDLSLSPSELETIVSLCNELEASNTLKGPSAVEAVVILLFKVATVWPAANRLPGLDLLRLFAAATPVTATADYNGKDLVSGIIESGVFDAPVNVNNAMLSVRMFANLFETDAGRRLIIDRFDQVIAAIRTCLTNSGSSVNRNLTIAVATLYINIAVFSTSEARNLSIESNQRGLILLEELTGMLRNEKDSEAVYRSLVALGTLVKELVSEVKAAAKEVYDLGAILQAISSSNLGKEPRIKGIVAEIKDSLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>C8VEE6</accession>
    <name>C8VEE6_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Cytochrome P450, putative (Eurofung)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">ANIA_08437</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="16">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF80550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468094.1">
        <property type="nucleotide sequence ID" value="XM_050612142.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VEE6"/>
    <dbReference type="GeneID" id="2868649"/>
    <dbReference type="KEGG" id="ani:ANIA_08437"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN8437"/>
    <dbReference type="eggNOG" id="KOG0158">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022195_7_0_1"/>
    <dbReference type="InParanoid" id="C8VEE6"/>
    <dbReference type="OMA" id="WFGSVHQ"/>
    <dbReference type="OrthoDB" id="1844152at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd11041">
        <property type="entry name" value="CYP503A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206:SF5">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12 13" id="KW-0349">Heme</keyword>
    <keyword evidence="9 12 13" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 13" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002993385" evidence="14">
        <location>
            <begin position="22"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="415"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CBF80550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="476" mass="53776" checksum="8FC9E500265077F3" modified="2009-11-03" version="1">MEITAYFCGALLLLLWYRVCARQSVDKTQVQLRQNIILVKNTPYAIPTPEAYQVHFSSATHIKQLIQAPDTHLSLHALAKDMFQPTHTMDGLAVDDCMSANGTIHQRALQAELRSHLPALTQPLSECIARTLTKEVSQASGSLAAVGDGWRALQLFPLAKRLVVSANALTFFGPEVSSNPIFLNAALEYPEHMMQTAEILRLLPSALTVLLDTLIPIIERRLYEHQSRPEQAEARVPRDCIQFFVNAVKHKKQLDKWHAQRIVQVLLGIWFASVHQPAMCLFYALDDLCLHPEYVVPLREKISQAVQIDISTLPLLDAFLKESARLHPTDSISVRRKALRPFTFSDGTSLAKGDVACIPLQPALQNPESYANPLTFNPHRFLKDKMTSTYIRSSRSRFTDADVAFPIWGLGKHACPGRHYASLLLKLVLAHVLLRYEIKLPDRNRRSEKRSFYWRSAIVPRSGAVLYFRERGSCTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>C8VEQ6</accession>
    <name>C8VEQ6_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ANIA_11619</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF80755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AN11619"/>
    <dbReference type="HOGENOM" id="CLU_3434148_0_0_1"/>
    <dbReference type="InParanoid" id="C8VEQ6"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF80755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="15" mass="1791" checksum="6CD1C61011B9803D" modified="2009-11-03" version="1">MTCTPKFREQPINLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>C8VF00</accession>
    <name>C8VF00_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ANIA_10647</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF80931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468141.1">
        <property type="nucleotide sequence ID" value="XM_050612195.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VF00"/>
    <dbReference type="STRING" id="227321.C8VF00"/>
    <dbReference type="GeneID" id="74896522"/>
    <dbReference type="KEGG" id="ani:ANIA_10647"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN10647"/>
    <dbReference type="eggNOG" id="KOG0684">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018012_0_0_1"/>
    <dbReference type="InParanoid" id="C8VF00"/>
    <dbReference type="OMA" id="FWNLVHI"/>
    <dbReference type="OrthoDB" id="3366823at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030448">
        <property type="term" value="P:hyphal growth"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="CDD" id="cd11040">
        <property type="entry name" value="CYP7_CYP8-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24306">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24306:SF7">
        <property type="entry name" value="AHBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0349">Heme</keyword>
    <keyword evidence="8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="511"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CBF80931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="570" mass="63910" checksum="C12FD9A73AEFDD70" modified="2009-11-03" version="1">MNTIQGAYDGLQPKTLVLAAIYILICVIIFTRILTGLQSYKKTDTAQPRRPRTAPYWIPWFGHSLSFARNHIEFLENTRHRLNETVFAIVMSGAKHNVVMSPSMIKSVLTFRGVTTAPLVQHVSRNILGDRGVFQKLNPSDRHVFVHNVPNQFMHEPSLSQTSGAAARFIERETPNLVTFSAAPIDQMLWERPGDVTVIEGKGQQVCEVDFFALIRYFVGTVTTTSLFGQAILDTFPTLLQDVWSVDDQFATLSMGPPRYLTPGISAAYMARDRLLDALAIFHQALLLWDEGKDLGMEFRDLRDLEDVSEPIKNRARMAKDMGLTPQESAPAHLALLWAMNGNSPNIVFYHLLHLYANPTLLEDLRKEIAPFVKVSRPTREETGFPILEAPRLSIDIDKLCDSCELLKASFYETLRLDSAGLSFRQLTADLTITESEEEASKAGRLTPESYSLKNGELVIIPHGVIHNDPTHFSNPDQFDPLRFIRTDPQSGQKYAKSETMTPFGGGMPACKGRAFAEKKILALSAAIISLWQITPAEGKKFKIPEHRISSAAFLPKNDIRVRMSPRYPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>C8VF30</accession>
    <name>C8VF30_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ANIA_11466</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF80986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VF30"/>
    <dbReference type="HOGENOM" id="CLU_3421363_0_0_1"/>
    <dbReference type="InParanoid" id="C8VF30"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF80986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="24" mass="2494" checksum="09EB6500DA7CC68F" modified="2009-11-03" version="1">MAEMVIMEASSLSINGFVPSGHSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>C8VFH0</accession>
    <name>C8VFH0_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Cytochrome P450, putative (Eurofung)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">ANIA_10704</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF81244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468191.1">
        <property type="nucleotide sequence ID" value="XM_050612249.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VFH0"/>
    <dbReference type="STRING" id="227321.C8VFH0"/>
    <dbReference type="GeneID" id="2872059"/>
    <dbReference type="KEGG" id="ani:ANIA_10704"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN10704"/>
    <dbReference type="eggNOG" id="KOG0157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020492_1_0_1"/>
    <dbReference type="InParanoid" id="C8VFH0"/>
    <dbReference type="OMA" id="HQNSDNI"/>
    <dbReference type="OrthoDB" id="10029320at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009403">
        <property type="term" value="P:toxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11051">
        <property type="entry name" value="CYP59-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000088">
        <property type="entry name" value="Cytochrome P450 monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF107">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0349">Heme</keyword>
    <keyword evidence="8 10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="10">
        <location>
            <position position="473"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CBF81244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="548" mass="62012" checksum="85D710D3D5DB5A5E" modified="2009-11-03" version="1">MAVTNLVLTLSIPLLTVIGYGLYCGFQHRRKINELRKRGIPMPKDWSWLTGHLLSLKKYTDRLPADAHVLLPTHELAVEFADTEMFLMDTWPVFPALVMVYDPDAALQISTKYNLPKSAIFPSLMHPITGGPSMISMNDAEWKKWRSIFNPGFSAGNMVDQVSTVVDSVQVFCDILREKAGTGLVHLDDLTTRLTMEVILKVTLDMDSNYQRSDNEMVHALNTITKWHSFWDPRVRANPLRPLVQKYYGRVMDRCIRKELDKRFAEMQQGQRSASTSKRVKSVIALALEAYLADYHQKDGKASKLDDNFAQYATHQIRLFLFAGNDTTSSSIVYVYHMLSKHPKALARVRQEHDRIFGTLPSAAPQLLKSNPALLNQCPYTLAVIKETLRLFPPASTTREGRDGVTLTDRLGNSYPLGHTIGAEIIHPTIHKNPRLWPQAEEFIPERWLVDPGHELYPSPAAWRPFEHGPRNCIGQTLVYNEMRIVIVMTARTFNIRPAYDEWDAMHAAKEGLLTVHGERAYQTEKAGTHPADGYPCHVALCSGSPIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>C8VFI3</accession>
    <name>C8VFI3_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_05756</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF81268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468197.1">
        <property type="nucleotide sequence ID" value="XM_050612255.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VFI3"/>
    <dbReference type="GeneID" id="2872046"/>
    <dbReference type="KEGG" id="ani:ANIA_05756"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN5756"/>
    <dbReference type="HOGENOM" id="CLU_1845080_0_0_1"/>
    <dbReference type="InParanoid" id="C8VFI3"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002992180" evidence="1">
        <location>
            <begin position="28"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF81268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="139" mass="15421" checksum="5483DA2DC43EA5BB" modified="2009-11-03" version="1">MISVLLTAHTIALSYIVITSIQSPSDGGEYAISAQTDNAYVPAETSVAQQTAGRLSARRDLSDTAEDSIKTSPITAQNIVSEYRQEPNKLKTSFLDLQDCASQSEKMRRSSLIWIPKFGLIHLLTRTIIEFLKRCTWAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>C8VGL9</accession>
    <name>C8VGL9_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Reticulon-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ANIA_05404</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Endoplasmic reticulum membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF81965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468270.1">
        <property type="nucleotide sequence ID" value="XM_050612336.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VGL9"/>
    <dbReference type="STRING" id="227321.C8VGL9"/>
    <dbReference type="GeneID" id="2871694"/>
    <dbReference type="KEGG" id="ani:ANIA_05404"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN5404"/>
    <dbReference type="eggNOG" id="KOG1792">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046578_1_0_1"/>
    <dbReference type="InParanoid" id="C8VGL9"/>
    <dbReference type="OMA" id="TGLMKQY"/>
    <dbReference type="OrthoDB" id="567788at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003388">
        <property type="entry name" value="Reticulon"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02453">
        <property type="entry name" value="Reticulon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50845">
        <property type="entry name" value="RETICULON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Reticulon" evidence="8">
        <location>
            <begin position="67"/>
            <end position="264"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="317"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBF81965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="326" mass="36200" checksum="7462035B52719133" modified="2009-11-03" version="1">MADNSEVRYPDPNANIKESITNGPVAETIRSEASRTGQEFRDLKSAKVIPSTTTATGQPLTYYHSLFYSLLSWEQPRATAASFASVVAFIFAARYLPLLRWFFKFLYLVLGVTAAAEIGGRVVLSQGLTSSFRPRKYYTLPRETIEAVLEDFQQLVDFLFIEFQRILFAENAVHTTAAAAAAFSAYWLIKILPFWGLSLLAVTIAYLGPFVYLNNQEIIDAQIENVRQMVGSQANQLKDLAEERTYHATGVVKQYVGDYSNKAQEYIGRRSASPEVAKGPAAGPVVKREPEPEAVVKTSDFPEAPKVEPVAQSIETQSEKEPLLAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>C8VHY6</accession>
    <name>C8VHY6_EMENI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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    <gene>
        <name evidence="2" type="ORF">ANIA_11383</name>
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    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
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            <taxon>Fungi</taxon>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF82974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468411.1">
        <property type="nucleotide sequence ID" value="XM_050612496.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VHY6"/>
    <dbReference type="GeneID" id="74896978"/>
    <dbReference type="KEGG" id="ani:ANIA_11383"/>
    <dbReference type="HOGENOM" id="CLU_3406370_0_0_1"/>
    <dbReference type="InParanoid" id="C8VHY6"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF82974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="30" mass="3658" checksum="A13E189DF3D4E1F6" modified="2009-11-03" version="1">MANFYIAMAFLALISGFPYWEWIRTNLFDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>C8VK18</accession>
    <name>C8VK18_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UDP-glucose dehydrogenase Ugd1, putative (AFU_orthologue AFUA_8G00920)</fullName>
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    <gene>
        <name evidence="3" type="ORF">ANIA_09172</name>
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        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF82393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468321.1">
        <property type="nucleotide sequence ID" value="XM_050612394.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VK18"/>
    <dbReference type="STRING" id="227321.C8VK18"/>
    <dbReference type="GeneID" id="2868086"/>
    <dbReference type="KEGG" id="ani:ANIA_09172"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN9172"/>
    <dbReference type="eggNOG" id="KOG2666">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_023810_7_1_1"/>
    <dbReference type="InParanoid" id="C8VK18"/>
    <dbReference type="OMA" id="CFIAVGT"/>
    <dbReference type="OrthoDB" id="5059218at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003979">
        <property type="term" value="F:UDP-glucose 6-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006024">
        <property type="term" value="P:glycosaminoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:001054">
        <property type="entry name" value="UDP-glucose dehydrogenase Ugd1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001732">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028356">
        <property type="entry name" value="UDPglc_DH_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11374:SF57">
        <property type="entry name" value="DEHYDROGENASE UGD1, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G00920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11374">
        <property type="entry name" value="UDP-GLUCOSE DEHYDROGENASE/UDP-MANNAC DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03721">
        <property type="entry name" value="UDPG_MGDP_dh_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDP-glucose/GDP-mannose dehydrogenase N-terminal" evidence="2">
        <location>
            <begin position="79"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="UDP-glucose/GDP-mannose dehydrogenase N-terminal" evidence="2">
        <location>
            <begin position="166"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF82393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="557" mass="61097" checksum="610AA4EEFA2A8844" modified="2009-11-03" version="1">MIFFFPILFALAGTCITLLFSNRIRQYRALVSKTRQPDRDRVVVKGHTYSEAVSGDQKTEVEFRSEGLSTISQIENVRQVCIIGAGKEGVITGIILASHNPEVEFCVADTDEELIRLWKSDTLPFSEPGLENMFFDDGALHATRSEDEKEDGKHANIDHGQDQDQQRLTGKETAAHVERRKKLSNLTFSADIHAALVPAQLVFLCLEMDPSAGASDESSSHSYLDSALYTIALASRGHKIIVQRSTAPYGATAYIKNRLQAISSPKATHTVLANPVLAVPFPGSLIASMITPSSVIIGHIFSSTASTPAITALKRLYASFVPEDRIVTMDAYSAELGTISAKAVIVQQMMALNSVHMICGKVEASPGNVGWILGGLDIAAVRTGVWMRREVRCLVNLAKGLGMEEVKAYWEGVLKLEGMKYRRDVRNFLETLNQGEDRKKAALILTDAMGDQETALVLLDELKRAEVTIRAWVDCATKEQSHNVLQTVRGRVEGLEVANSLESACAGSNVVILHGSLGIRDEAMQAIADNMERPKALLNLGDRMDEMKMRQLGFRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>C8VLY8</accession>
    <name>C8VLY8_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ANIA_02108</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF86194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_659712.2">
        <property type="nucleotide sequence ID" value="XM_654620.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VLY8"/>
    <dbReference type="GeneID" id="2875494"/>
    <dbReference type="KEGG" id="ani:ANIA_02108"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN2108"/>
    <dbReference type="eggNOG" id="ENOG502SHS7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079936_0_0_1"/>
    <dbReference type="InParanoid" id="C8VLY8"/>
    <dbReference type="OMA" id="FRIVHRI"/>
    <dbReference type="OrthoDB" id="3934549at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF165">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="124"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="256"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="30"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBF86194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="303" mass="32892" checksum="34419A228C2C1B35" modified="2009-11-03" version="1">MNDSGHTGFDETYFIVTWVEFVIAIFLLAARCHTALCIVKRVAADLPLAILTFILGAASMVMLTLAAQAGLGVPGPVLNMTENRYALLFGWLNQFFALIAIGLGKLTIVAFLQQIQGYHTLFRTIFLWTLAGSNFIVNCIAAALAIVQCDPVQRLWAESLPGECPGRERIQIFGYVQGAWSALCDFALALFPVVLFARIRAISIPTRIGLCLLMGSGVVAGACTIVKTIRLSNLTTFTDATHQMGNVIVWNQSEMWLVFIVSCLPPTKVFFASLCSGGAKSLSSLYGRLGWHGSSEEGQIAVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>C8VPR1</accession>
    <name>C8VPR1_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ANIA_01848</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF85681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468745.1">
        <property type="nucleotide sequence ID" value="XM_050612882.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VPR1"/>
    <dbReference type="STRING" id="227321.C8VPR1"/>
    <dbReference type="GeneID" id="2875741"/>
    <dbReference type="KEGG" id="ani:ANIA_01848"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN1848"/>
    <dbReference type="eggNOG" id="ENOG502RX7Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011522_0_0_1"/>
    <dbReference type="InParanoid" id="C8VPR1"/>
    <dbReference type="OMA" id="PFNMTLT"/>
    <dbReference type="OrthoDB" id="5294180at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
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    <dbReference type="GO" id="GO:0005634">
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        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="AspGD"/>
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    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
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        <property type="term" value="P:ascospore formation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="AspGD"/>
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        <property type="term" value="P:cleistothecium development"/>
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        <property type="project" value="AspGD"/>
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    <dbReference type="GO" id="GO:0006351">
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        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="AspGD"/>
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    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Fun_TF"/>
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    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
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    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
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    <dbReference type="PANTHER" id="PTHR37534:SF50">
        <property type="entry name" value="NOSA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="44"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="620"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="10"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBF85681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="675" mass="75590" checksum="08C9D5C5ACE913E1" modified="2009-11-03" version="1">MPAAPRKKATAAAKRAAESQASSGSESTPKPEGTTKSHKRSRSGCFTCRLRRKKCDEKHPSCGACNNLCVKCEYKRPVWWGNAEQRKMHKERIKNKIKQTKMNERNGSLAIDPASRVRSMAANSPTSPEFEYGRPFPEPSYDIFASQFPTPAMAQTIYAPQYPYEVDVKTEHQTFVNDVQLRHDSVSSTFSTFAPPQLNAPLPTFPGDEWFHDEYFRAPVLPGIDPALCEQPFPETYDMLQNIPVSDHDRPLLEHFIHNVLRVSFPVLEAHQRGHMRAQAVLQTLETNKCYLHCCLSVAAIHLKTTEGITGEQIDHDIMRNRFEAISQLCQALGDDTEHQEILDATLAMIFFHSSVGPADDYLPDIPWLDHFQAAANLVQRLGLTADAPNPYVLPPFSMTLTAWIDILGSTMYRRTPEFAHTYRSKHLGGVSLGLRELMGCEDRVMYLISEIACLDALKSDGRVDEMQVCSHVSALGQQLEFTEPPDQIMESPFSATTGLLRPEVLTKNMTAVFRIAARIYLCSLVPGFEATQPSNINLVQALANTLQYIPSGPDGFDRSLVWPLFIAGVHSLPGSQFRTVLMERAAALAEHADLGSFGRMCRVLQEVWRVNDEFAEQHSSLDEGASSSSQTASPVKAEPPSSPRESENSWTTKEAKKPHWRDIMQQNGWNYLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>C8VPT6</accession>
    <name>C8VPT6_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid transporter (Eurofung)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ANIA_10319</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF87082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468923.1">
        <property type="nucleotide sequence ID" value="XM_050613081.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VPT6"/>
    <dbReference type="STRING" id="227321.C8VPT6"/>
    <dbReference type="GeneID" id="2875568"/>
    <dbReference type="KEGG" id="ani:ANIA_10319"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN10319"/>
    <dbReference type="eggNOG" id="KOG1287">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013661_4_1_1"/>
    <dbReference type="InParanoid" id="C8VPT6"/>
    <dbReference type="OMA" id="AMHICAK"/>
    <dbReference type="OrthoDB" id="5982228at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003333">
        <property type="term" value="P:amino acid transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF382">
        <property type="entry name" value="LOW-AFFINITY METHIONINE PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="265"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="314"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="355"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="395"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="426"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="460"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBF87082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="514" mass="55979" checksum="C22BF7D87D8DBD5E" modified="2009-11-03" version="1">MESSLRDSSPMAEDSHEHAVLLPRELPDTDRDEYDGFSRQRRHLGLLSTTFLITNRMIGTAIFSTPSAIAASVGSAGAALALWVVGLILAYCGLFIWIELGSLMPRSGGEKVYLEAAYPNPPMLVTTVFAVHIIFLGFTGIGSVVVAENILLALNGSATDWVKRGLAIAVLAIIATIHIRFSALGVKIMILILFLIIVAGLRALRGDLPQIPDPASSLKSPFTGSSSSVSRYTNALFKILATYQGWSNAAYVLDEVKDPRKVLKIAGVVGVGLVGILYTLTNISYFIVATPDEISKTGVTVVALLIGKVFGDTMLWLTATLAALSSFGNLMTASFTMSRVVREFAREGIVPYSRFFAATTSSGSPSAAFLLVFLSSAVMILFIPFGEVYNFLLDVSQYAIALVNVLVVIALFIIRRKQPHRRTFRAWTPVIYLFLASQVFLLVTPFIPAALDTGRALPPWLYSVVALLVFFGSGVYWFMSWEVLPRRGQFVWTARESVLADGSSVVLWDKVKIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C8VQV2</accession>
    <name>C8VQV2_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Exo-beta-1,3-glucanase, putative (AFU_orthologue AFUA_6G11980)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ANIA_00779</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF88800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050469135.1">
        <property type="nucleotide sequence ID" value="XM_050613308.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VQV2"/>
    <dbReference type="GeneID" id="2876550"/>
    <dbReference type="KEGG" id="ani:ANIA_00779"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN0779"/>
    <dbReference type="eggNOG" id="ENOG502QV54">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002540_2_1_1"/>
    <dbReference type="InParanoid" id="C8VQV2"/>
    <dbReference type="OMA" id="AVFMNWN"/>
    <dbReference type="OrthoDB" id="1046782at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23668">
        <property type="entry name" value="GH55_beta13glucanase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000023">
        <property type="entry name" value="Exo-beta-1,3-glucanase Exg0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000026">
        <property type="entry name" value="Exo-beta-1,3-glucanase Exg0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039279">
        <property type="entry name" value="QRT3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024535">
        <property type="entry name" value="RHGA/B-epi-like_pectate_lyase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33928:SF2">
        <property type="entry name" value="PECTATE LYASE SUPERFAMILY PROTEIN DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33928">
        <property type="entry name" value="POLYGALACTURONASE QRT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12708">
        <property type="entry name" value="Pect-lyase_RHGA_epim"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002993452" evidence="4">
        <location>
            <begin position="19"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="domain" description="Rhamnogalacturonase A/B/Epimerase-like pectate lyase" evidence="5">
        <location>
            <begin position="60"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="Rhamnogalacturonase A/B/Epimerase-like pectate lyase" evidence="5">
        <location>
            <begin position="413"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBF88800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="781" mass="84101" checksum="40B99BD407C73684" modified="2009-11-03" version="1">MRFTNILLLLAGSAWVGASPVASGETEIVARQSSSEYWVGTIENRGAVPFGDDADYQVHRNVKDFGAVGDGTTDDTDAINKAISSGNRCGQGCDSSTTKPAVVYFPAGTYLVSKPIVQYYYTQMVGDANNLPVLKASADFSGMAVVDADPYTDDGSNWYTNQNNFFRSIRNFVVDLTAMPQSSGAGIHWQVGQATSLQNIRFEMIKGGGSENKQQGIFMDNGSGGFMTDLTFNGGNYGMFVGNQQFTSRNLTFNDCNTGVYMNWNWAWTFKSITFNNCNLGLNMSNSPSNQTVGSVLLLDTEFVNTPTGVVTAWGSDSIPVGAGTLVLDNVDFSGATTGVAGVDGTAILAGGSVVDNWVQGGIYRPASVNKRATRIQTALPGATKPASLLSSSSGKIFERSKPLYESYASSSFISVKANGAKGDGSTDDTAAIQKIFDSATSDQVVYFDHGAYVLTDTVKVPSNIKIVGEVWPVLMAYGDKFSDEQNPIPLLQVGQPGETGSVEISDLTILTKGPAPGAILMEWNVAEETPGSVGMWDVHFRIGGSAGTELQSDTCAKTPNSTTTPNTQCIGAFMLLHLTEKSTAYLENVWSWTADHELDLDDHNQINIYNGRGILVESQGPVWMYGTAAEHNQLYNYQVSNAKNIFMGLIQTETPYYQANPNALVPFTPQDSWNDPDFSYCTTDACRKAWGLRVINSSSVYVYGAGLYSFFENYGQECLGDSCQENMVQVDCSDVHIFGLSTIASENMITNSDGSSLVPQEGNKSTYCSTIALFEQTSQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2025-10-08" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>C8VQZ9</accession>
    <name>C8VQZ9_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">succinate-semialdehyde dehydrogenase [NAD(P)(+)]</fullName>
            <ecNumber evidence="6">1.2.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ANIA_10011</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>succinate semialdehyde + NAD(+) + H2O = succinate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13217"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57706"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>succinate semialdehyde + NADP(+) + H2O = succinate + NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13213"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57706"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.2.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; 4-aminobutanoate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.16" evidence="6"/>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF90243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_657683.2">
        <property type="nucleotide sequence ID" value="XM_652591.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VQZ9"/>
    <dbReference type="FunCoup" id="C8VQZ9">
        <property type="interactions" value="441"/>
    </dbReference>
    <dbReference type="STRING" id="227321.C8VQZ9"/>
    <dbReference type="GeneID" id="2875856"/>
    <dbReference type="KEGG" id="ani:ANIA_10011"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN10011"/>
    <dbReference type="eggNOG" id="KOG2451">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005391_5_4_1"/>
    <dbReference type="InParanoid" id="C8VQZ9"/>
    <dbReference type="OMA" id="QFDNNRR"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004777">
        <property type="term" value="F:succinate-semialdehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009450">
        <property type="term" value="P:gamma-aminobutyric acid catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd07103">
        <property type="entry name" value="ALDH_F5_SSADH_GabD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000004">
        <property type="entry name" value="Succinate-semialdehyde dehydrogenase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000005">
        <property type="entry name" value="Succinate-semialdehyde dehydrogenase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050740">
        <property type="entry name" value="Aldehyde_DH_Superfamily"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353:SF11">
        <property type="entry name" value="SUCCINATE SEMIALDEHYDE DEHYDROGENASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353">
        <property type="entry name" value="SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="9">
        <location>
            <begin position="24"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00050387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00052698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00067047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBF90243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="497" mass="53104" checksum="A806656699A7DEF4" modified="2009-11-03" version="1">MPSLANTLKDPTLFIESSYIDGKWVTSSSSRTFNVYDPATEEFIGTCPESNIDDINSAIRAAATAFPKWRALSGRQRGRILRRWFDLIVENKEDIGKIITAENGKAKGDAEGEALFSAGFFEWFSEEAARIYGDVVPHSNPSSRVQVLKEPVGVCGLITPWNFPMAMGARKVAAALAAGCTVVLKSDGLTPYSSNVLALLAERAGVPGGVFNVVTALENTPALGLALCESDNVKKISFTGSTRVGKLLMKQSSHTLKKLSLELGGNAPFIVFDDADLETAVTSAVACKFKVTGQTCVCANRFYVQEGIYEAFSKRFVEEVKKCQVGHGLDPGVTHGPLTNGIAKTQEHIQDALNKGATVLLGGSRLPSLGKNFHELTILGDVDDSMKVASEETFGPLAALSKFKAEDEVVRRANGVEVGLASYLITSDLGKAHRVSEKLEFGMVAINTGVISDSAAPFGGVKHSGMGREGSKYGIDDYLNIKTIVTGGIHTAYSAHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>C8VSZ1</accession>
    <name>C8VSZ1_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ketoreductase (KR) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_10094</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF89384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050469207.1">
        <property type="nucleotide sequence ID" value="XM_050613387.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VSZ1"/>
    <dbReference type="FunCoup" id="C8VSZ1">
        <property type="interactions" value="26"/>
    </dbReference>
    <dbReference type="GeneID" id="74896198"/>
    <dbReference type="KEGG" id="ani:ANIA_10094"/>
    <dbReference type="HOGENOM" id="CLU_1547521_0_0_1"/>
    <dbReference type="InParanoid" id="C8VSZ1"/>
    <dbReference type="OMA" id="IHAHPGM"/>
    <dbReference type="OrthoDB" id="2898509at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052228">
        <property type="entry name" value="Sec_Metab_Biosynth_Oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47534:SF2">
        <property type="entry name" value="KETOREDUCTASE (KR) DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47534">
        <property type="entry name" value="YALI0E05731P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF89384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="211" mass="23235" checksum="AD4D349EF432D549" modified="2009-11-03" version="1">MVPINLVRSSNAALRSIPSTSHSAGITALFVSGTSGIGLYTLRALTRHTEGKALTVYIVGRSAYRAKPVLSELQRISPRARFTFIEADVSLIRNVDSVCKKVIESEKGGKGKLDSLFMTPGGISIPFRRRETSEELDRLFALRYYARMRIIQNLLPLLESELEPSTSPGPNSIPSRMVSIHGSGFEYGINLDDLNLKHNFSLLNACNTPLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>C8VU20</accession>
    <name>C8VU20_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ANIA_11267</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF89726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050469256.1">
        <property type="nucleotide sequence ID" value="XM_050610980.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VU20"/>
    <dbReference type="STRING" id="227321.C8VU20"/>
    <dbReference type="GeneID" id="74896877"/>
    <dbReference type="KEGG" id="ani:ANIA_11267"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN11267"/>
    <dbReference type="HOGENOM" id="CLU_2399675_0_0_1"/>
    <dbReference type="InParanoid" id="C8VU20"/>
    <dbReference type="OrthoDB" id="2156052at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF89726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="93" mass="10321" checksum="FF5DA0375355F7E6" modified="2009-11-03" version="1">MDLWEKVVKSKTIPAEGPEKLRHNAARLTGSSVVQEYDVMLEAGLEYSYLTYGLALVLLRVDYDEPGTLYTTAPLTAILDIVFVPHELPLAIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>C8VUX2</accession>
    <name>C8VUX2_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">tRNA-splicing endonuclease subunit Sen34</fullName>
            <ecNumber evidence="5">4.6.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ANIA_00190</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. It probably carries the active site for 3'-splice site cleavage.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the tRNA-intron endonuclease family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.16" evidence="5"/>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF90007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_657794.2">
        <property type="nucleotide sequence ID" value="XM_652702.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VUX2"/>
    <dbReference type="FunCoup" id="C8VUX2">
        <property type="interactions" value="150"/>
    </dbReference>
    <dbReference type="STRING" id="227321.C8VUX2"/>
    <dbReference type="GeneID" id="2875967"/>
    <dbReference type="KEGG" id="ani:ANIA_00190"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN0190"/>
    <dbReference type="eggNOG" id="KOG4133">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049366_0_0_1"/>
    <dbReference type="InParanoid" id="C8VUX2"/>
    <dbReference type="OMA" id="RTFSLEW"/>
    <dbReference type="OrthoDB" id="48041at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000214">
        <property type="term" value="C:tRNA-intron endonuclease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000213">
        <property type="term" value="F:tRNA-intron lyase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000379">
        <property type="term" value="P:tRNA-type intron splice site recognition and cleavage"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd22363">
        <property type="entry name" value="tRNA-intron_lyase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1350.10:FF:000008">
        <property type="entry name" value="tRNA-splicing endonuclease subunit Sen34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036167">
        <property type="entry name" value="tRNA_intron_Endo_cat-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006677">
        <property type="entry name" value="tRNA_intron_Endonuc_cat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006676">
        <property type="entry name" value="tRNA_splic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016690">
        <property type="entry name" value="TSEN34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059049">
        <property type="entry name" value="TSEN34_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00324">
        <property type="entry name" value="endA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13070:SF0">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13070">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN34-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01974">
        <property type="entry name" value="tRNA_int_endo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26577">
        <property type="entry name" value="TSEN34_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017250">
        <property type="entry name" value="tRNA_splic_SEN34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53032">
        <property type="entry name" value="tRNA-intron endonuclease catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TSEN34 N-terminal" evidence="9">
        <location>
            <begin position="9"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA intron endonuclease catalytic" evidence="8">
        <location>
            <begin position="213"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="113"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="118"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="163"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="240"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="248"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00059865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR017250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR017250-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF26577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBF90007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="310" mass="34217" checksum="2FFF590204341C12" modified="2009-11-03" version="1">MNPSPDLPIPISYIAGNYFVFSVDAATFLRREHHICGVLAGTLPQVPQQNIFTGLPLELMPEEARLLAEKGVACIVDEVNFQKQGMNCLVEEDRKKYLEELELQGVESMQLQVRRKERQREEALKKKNEKAAAKAKKTERKQDTAEPASGEDSIVPFFDDAQPSVSPNHVSSRRPSTLATPDAMGITPAVSHPPLPQQPPAEHLLSLPEVPSSYPLFAHLHSKGYFLSPGLRFGCQYMAYPGDPLRFHSHFLVVSAEWDEQLDLMTIITGGRLGTGVKKGFLIGGADKSRGDPEEAGANVRSFSIEWAGM</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1993-04-01" modified="2025-06-18" version="137" xmlns="https://uniprot.org/uniprot">
    <accession>P30303</accession>
    <accession>C8V635</accession>
    <accession>Q5B689</accession>
    <name>MPIP_EMENI</name>
    <protein>
        <recommendedName>
            <fullName>M-phase inducer phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">nimT</name>
        <name type="ORF">AN3941</name>
    </gene>
    <organism>
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1992" name="EMBO J." volume="11" first="2139" last="2149">
            <title>An extra copy of nimEcyclinB elevates pre-MPF levels and partially suppresses mutation of nimTcdc25 in Aspergillus nidulans.</title>
            <authorList>
                <person name="O'Connell M.J."/>
                <person name="Osmani A.H."/>
                <person name="Morris N.R."/>
                <person name="Osmani S.A."/>
            </authorList>
            <dbReference type="PubMed" id="1534750"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA]</scope>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <source>
            <strain>GB20</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">This protein functions as a dosage-dependent inducer in mitotic control. It is a tyrosine protein phosphatase required for progression of the cell cycle. It may directly dephosphorylate p34(cdc2) and activate the p34(cdc2) kinase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the MPI phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="4"/>
    <dbReference type="EMBL" id="X64601">
        <property type="protein sequence ID" value="CAA45885.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AACD01000064">
        <property type="protein sequence ID" value="EAA59250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF75046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="S24395">
        <property type="entry name" value="S24395"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_661545.1">
        <property type="nucleotide sequence ID" value="XM_656453.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P30303"/>
    <dbReference type="SMR" id="P30303"/>
    <dbReference type="STRING" id="227321.P30303"/>
    <dbReference type="EnsemblFungi" id="CBF75046">
        <property type="protein sequence ID" value="CBF75046"/>
        <property type="gene ID" value="ANIA_03941"/>
    </dbReference>
    <dbReference type="GeneID" id="2873361"/>
    <dbReference type="KEGG" id="ani:ANIA_03941"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN3941"/>
    <dbReference type="eggNOG" id="KOG3772">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017900_0_0_1"/>
    <dbReference type="InParanoid" id="P30303"/>
    <dbReference type="OMA" id="HSPQMED"/>
    <dbReference type="OrthoDB" id="26523at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000086">
        <property type="term" value="P:G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010971">
        <property type="term" value="P:positive regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110032">
        <property type="term" value="P:positive regulation of G2/MI transition of meiotic cell cycle"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045840">
        <property type="term" value="P:positive regulation of mitotic nuclear division"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="CDD" id="cd01530">
        <property type="entry name" value="Cdc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.250.10:FF:000021">
        <property type="entry name" value="M-phase inducer phosphatase cdc-25.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000751">
        <property type="entry name" value="MPI_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10828">
        <property type="entry name" value="M-PHASE INDUCER PHOSPHATASE DUAL SPECIFICITY PHOSPHATASE CDC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10828:SF17">
        <property type="entry name" value="PROTEIN-TYROSINE-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00716">
        <property type="entry name" value="MPIPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0132">Cell division</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0498">Mitosis</keyword>
    <keyword id="KW-0904">Protein phosphatase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000198660" description="M-phase inducer phosphatase">
        <location>
            <begin position="1"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="2">
        <location>
            <begin position="371"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="257"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="505"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="287"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="505"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="421"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; CAA45885." evidence="5" ref="1">
        <original>P</original>
        <variation>G</variation>
        <location>
            <position position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="1534750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <evidence type="ECO:0000305" key="6">
        <source>
            <dbReference type="PubMed" id="1534750"/>
        </source>
    </evidence>
    <sequence length="556" mass="61626" checksum="F558E77944A0BA59" modified="2007-05-01" version="2">MEHSSPLAAMQPPSVMLGHCFRSDAPTSYHGFSPLPGLGPGGFNFKDLSMKRSNGDYFGTKVVRGSSPTASLAADLSQNFHIDQSPQVATPRRSLFSACLLGNGNRRGVDDAMTTPPLPSSSPAPAMDIMDMSPLPHKPPFISTPEIELDSPTLESSPMDTTMMSTDGLVPDSPTVLPKDGKQERRRPTFLRPSLARSKAQSFQVGMTRPAPESQGPPFKFQTNGINKTSSGVAASLEDMFGESPQRERPMMRINSTSGLNSRLRPPLGSGSHVRGNGSPSAASVRKSAHPNMRPRKQCRRSLSMYEHPEDVIADSEVSYTSNAPLQSISDFEETQALQLPHFIPEEQADNLPRIDKATLVDIKEGKYDNMFDNIMIIDCRFEYEYDGGHIVGAVNYNDKENLAAELFADPKPRTAIVFHCEYSVHRAPLMAKYIRHRDRAYNVDHYPQLSYPDMYILEGGYSGFFAEHRSLCYPQNYVEMSAKEHEFACERGLGKVKQRSKLSRAQTFAFGQQSPEMEDSPTGRCRNNPGDRKLLASPFNDSPGSRFPGRRMLSY</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2002-06-06" modified="2026-01-28" version="155" xmlns="https://uniprot.org/uniprot">
    <accession>Q02398</accession>
    <accession>C8VCP5</accession>
    <accession>Q00178</accession>
    <accession>Q00183</accession>
    <accession>Q5AWM1</accession>
    <name>RAD18_EMENI</name>
    <protein>
        <recommendedName>
            <fullName>Postreplication repair E3 ubiquitin-protein ligase rad18</fullName>
            <ecNumber evidence="1">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">RING-type E3 ubiquitin transferase rad18</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">uvsH</name>
        <name type="synonym">nuvA</name>
        <name type="synonym">rad18</name>
        <name type="ORF">AN7309</name>
    </gene>
    <organism>
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1995" name="Mol. Gen. Genet." volume="248" first="174" last="181">
            <title>The Aspergillus uvsH gene encodes a product homologous to yeast RAD18 and Neurospora UVS-2.</title>
            <authorList>
                <person name="Yoon J.H."/>
                <person name="Lee B.J."/>
                <person name="Kang H.S."/>
            </authorList>
            <dbReference type="PubMed" id="7651340"/>
            <dbReference type="DOI" id="10.1007/BF02190798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1996" name="Microbiology" volume="142" first="505" last="515">
            <title>nuvA, an Aspergillus nidulans gene involved in DNA repair and recombination, is a homologue of Saccharomyces cerevisiae RAD18 and Neurospora crassa uvs-2.</title>
            <authorList>
                <person name="Iwanejko L.A."/>
                <person name="Cotton C.M."/>
                <person name="Jones G.W."/>
                <person name="Tomsett A.B."/>
                <person name="Strike P."/>
            </authorList>
            <dbReference type="PubMed" id="8868425"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]</scope>
        <source>
            <strain>L20</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Together with the E2 ubiquitin conjugating enzyme uvsJ/ubc2, monoubiquitinates PCNA to promote two parallel branches of the DNA damage tolerance (DDT) pathway (also known as the post-replication repair (PRR) pathway) that bypasses replication-blocking lesions without removing them; monoubiquitination promotes the translesion synthesis (TLS) pathway and leads to the recruitment of translesion polymerases for lesion bypass, whereas further polyubiquitination of PCNA promotes template-switching (TS) to the newly synthesized sister chromatid for synthesis past the lesion.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Interacts with E2 UBC2, forming a complex with ubiquitin ligase activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the RAD18 family.</text>
    </comment>
    <comment type="sequence caution" evidence="6">
        <conflict type="erroneous gene model prediction">
            <sequence resource="EMBL-CDS" id="AAB35098" version="1"/>
        </conflict>
    </comment>
    <comment type="sequence caution" evidence="6">
        <conflict type="erroneous gene model prediction">
            <sequence resource="EMBL-CDS" id="CAA90033" version="1"/>
        </conflict>
    </comment>
    <comment type="sequence caution" evidence="6">
        <conflict type="erroneous gene model prediction">
            <sequence resource="EMBL-CDS" id="EAA61360" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="1"/>
    <dbReference type="EMBL" id="S79392">
        <property type="protein sequence ID" value="AAB35098.1"/>
        <property type="status" value="ALT_SEQ"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="Z49875">
        <property type="protein sequence ID" value="CAA90033.1"/>
        <property type="status" value="ALT_SEQ"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="Z49834">
        <property type="protein sequence ID" value="CAA89995.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AACD01000127">
        <property type="protein sequence ID" value="EAA61360.1"/>
        <property type="status" value="ALT_SEQ"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF78646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="S55494">
        <property type="entry name" value="S55494"/>
    </dbReference>
    <dbReference type="PIR" id="S57328">
        <property type="entry name" value="S57328"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q02398"/>
    <dbReference type="SMR" id="Q02398"/>
    <dbReference type="FunCoup" id="Q02398">
        <property type="interactions" value="293"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q02398"/>
    <dbReference type="EnsemblFungi" id="CBF78646">
        <property type="protein sequence ID" value="CBF78646"/>
        <property type="gene ID" value="ANIA_07309"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AN7309"/>
    <dbReference type="eggNOG" id="KOG0287">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028491_1_1_1"/>
    <dbReference type="InParanoid" id="Q02398"/>
    <dbReference type="OMA" id="IPNTGPR"/>
    <dbReference type="OrthoDB" id="9049620at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097505">
        <property type="term" value="C:Rad6-Rad18 complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006301">
        <property type="term" value="P:DNA damage tolerance"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006513">
        <property type="term" value="P:protein monoubiquitination"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000172">
        <property type="entry name" value="E3 ubiquitin-protein ligase RAD18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039577">
        <property type="entry name" value="Rad18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004580">
        <property type="entry name" value="Rad18_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006642">
        <property type="entry name" value="Rad18_UBZ4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00599">
        <property type="entry name" value="rad18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14134">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RAD18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14134:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RAD18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00734">
        <property type="entry name" value="ZnF_Rad18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51908">
        <property type="entry name" value="ZF_UBZ4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <keyword id="KW-0863">Zinc-finger</keyword>
    <feature type="chain" id="PRO_0000056156" description="Postreplication repair E3 ubiquitin-protein ligase rad18">
        <location>
            <begin position="1"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="SAP" evidence="3">
        <location>
            <begin position="239"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="RING-type" evidence="2">
        <location>
            <begin position="30"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="UBZ4-type" evidence="4">
        <location>
            <begin position="175"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="106"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="350"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="143"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="350"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="431"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="sequence conflict" description="In Ref. 2; CAA90033." evidence="6" ref="2">
        <original>FG</original>
        <variation>YR</variation>
        <location>
            <begin position="209"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P10862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="6"/>
    <sequence length="443" mass="48907" checksum="DD3327065D3511B2" modified="1996-11-01" version="1">MEPTFDIPDSTDWLDTPLTLLAPFETSLRCQVCKDFFDNPVITSCSHTFCSLCIRRCLSTEGKCPTCRSSDQELKLRRNWVVQELVEGFKNARPSILQLARMAQTGTDDSGDLAAEEPASKKRKIEPNAIVGTDGLPEEGIRTRSQSRGASRQPQATPVQVIDDGNDEDYMPDGLVPCPVCGRRMKEEAVFRHLDSCTGTAEELKPAAFGSLAPGPRKSFLAATGKPPERLPVINYSLLKDTVLRKKLKDLGIPNWGPRALLQRRHTEWLNLWNANCDSRTPKPKRELLRELDVWERTQGGNSVTPTDPTNAVMNKDFNTEEWSANYDTDFKALIANARKKNDAVIRSTIPNASQANSDTPRSAQLVDQPIEASLTPQDVDEKSTMNPQDAIDNRTEVPPVPDPPQALSGIDRAVNSPMKNVTEGDAQAIPISSSASTHKTPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AQI0</accession>
    <accession>C8VUA8</accession>
    <name>Q5AQI0_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_09450</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF89795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_868832.1">
        <property type="nucleotide sequence ID" value="XM_863739.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AQI0"/>
    <dbReference type="STRING" id="227321.Q5AQI0"/>
    <dbReference type="GeneID" id="3684043"/>
    <dbReference type="KEGG" id="ani:ANIA_09450"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN9450"/>
    <dbReference type="eggNOG" id="ENOG502SFMK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096545_1_1_1"/>
    <dbReference type="InParanoid" id="Q5AQI0"/>
    <dbReference type="OMA" id="CCIAGCF"/>
    <dbReference type="OrthoDB" id="5597238at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010219495" evidence="2">
        <location>
            <begin position="18"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="146"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF89795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="193" mass="19148" checksum="43A77FF8AF6BFD8D" modified="2005-04-26" version="1">MKVSLVTLTSVLALVAAQDSSSSSESSTETSTAPTTTPSLTAAERCALNCGDNDLCCVAACYSVPCPSDQQANNTNTCVSQCDQGDGSEEDIQAYAECQARCISSTYFPGTVTVTSAPTGSSTGSNTATTTSSGDDADSTDDSNSDDSSATSTNGDEATATGSGDEPSDTNAAARLGVSAAGLAGLLMAAWAL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2016-11-02" modified="2025-04-09" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AR46</accession>
    <accession>C8VJP5</accession>
    <name>ASQC_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Dehydratase asqC</fullName>
            <ecNumber evidence="4">4.2.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">4'-methoxyviridicatin/aspoquinolone biosynthesis cluster protein asqC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Aspoquinolone biosynthesis protein C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">asqC</name>
        <name type="ORF">AN9234</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2014" name="Angew. Chem. Int. Ed." volume="53" first="12880" last="12884">
            <title>Non-heme dioxygenase catalyzes atypical oxidations of 6,7-bicyclic systems to form the 6,6-quinolone core of viridicatin-type fungal alkaloids.</title>
            <authorList>
                <person name="Ishikawa N."/>
                <person name="Tanaka H."/>
                <person name="Koyama F."/>
                <person name="Noguchi H."/>
                <person name="Wang C.C."/>
                <person name="Hotta K."/>
                <person name="Watanabe K."/>
            </authorList>
            <dbReference type="PubMed" id="25251934"/>
            <dbReference type="DOI" id="10.1002/anie.201407920"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2017" name="Nat. Chem. Biol." volume="13" first="325" last="332">
            <title>Enzyme-catalyzed cationic epoxide rearrangements in quinolone alkaloid biosynthesis.</title>
            <authorList>
                <person name="Zou Y."/>
                <person name="Garcia-Borras M."/>
                <person name="Tang M.C."/>
                <person name="Hirayama Y."/>
                <person name="Li D.H."/>
                <person name="Li L."/>
                <person name="Watanabe K."/>
                <person name="Houk K.N."/>
                <person name="Tang Y."/>
            </authorList>
            <dbReference type="PubMed" id="28114276"/>
            <dbReference type="DOI" id="10.1038/nchembio.2283"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>PATHWAY</scope>
    </reference>
    <comment type="function">
        <text evidence="3 4 6">Dehydratase; part of the gene cluster that mediates the biosynthesis of the aspoquinolone mycotoxins (PubMed:25251934, PubMed:28114276). Within the pathway, the dehydratase asqC catalyzes the dehydratation of the epoxide at C-3 to produce (1'E,3'E)-5-(3,3-dimethyloxiran-2-yl)-3-methylhexa-1,3-dienyl-quinolinone B (PubMed:28114276). The first step of the pathway is catalyzed by the nonribosomal peptide synthetase asqK that condenses anthranilic acid and O-methyl-L-tyrosine to produce 4'-methoxycyclopeptin. 4'-methoxycyclopeptin is then converted to 4'-methoxydehydrocyclopeptin by the ketoglutarate-dependent dioxygenase asqJ. AsqJ also converts its first product 4'-methoxydehydrocyclopeptin to 4'-methoxycyclopenin. The following conversion of 4'-methoxycyclopenin into 4'-methoxyviridicatin is catalyzed by the cyclopenase asqI. 4'-methoxyviridicatin is the precursor of quinolone natural products, and is further converted to quinolinone B. The prenyltransferase asqH1 then catalyzes the canonical Friedel-Crafts alkylation of quinolinone B with dimethylallyl cation to yield dimethylallyl quinolone, which is subjected to FAD-dependent dehydrogenation by the FAD-linked oxidoreductase asqF to yield conjugated aryl diene. The delta(3') double bond then serves as the site of the second alkylation with DMAPP catalyzed by the prenyltransferase asqH2 to yield a carbenium ion intermediate, which can be attacked by H(2)O to yield a styrenyl quinolone containing a C3'-hydroxyprenyl chain. The FAD-dependent monooxygenase asqG performs epoxidation of the terminal C7'-C8' olefin. Finally, after dehydratation of the epoxide at C3 by asqC, the quinolone epoxide rearrangement protein asqO catalyzes an enzymatic 3-exo-tet cyclization to yield the cyclopropyl-THF ring system in aspoquinolone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>[(1'E)-5'-(3',3'-dimethyloxiran-2'-yl)-3'-hydroxy-3'-methylpent-1'-en-1'-yl]-quinolinone B = (1'E,3'E)-5-(3,3-dimethyloxiran-2-yl)-3-methylhexa-1,3-dienyl-quinolinone B + H2O</text>
            <dbReference type="Rhea" id="RHEA:74507"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:193079"/>
            <dbReference type="ChEBI" id="CHEBI:193561"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:74508"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Alkaloid biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Mycotoxin biosynthesis.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.-" evidence="4"/>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF82265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AACD01000170">
        <property type="protein sequence ID" value="EAA61525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_682503.1">
        <property type="nucleotide sequence ID" value="XM_677411.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AR46"/>
    <dbReference type="SMR" id="Q5AR46"/>
    <dbReference type="STRING" id="227321.Q5AR46"/>
    <dbReference type="GlyCosmos" id="Q5AR46">
        <property type="glycosylation" value="7 sites, No reported glycans"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CBF82265">
        <property type="protein sequence ID" value="CBF82265"/>
        <property type="gene ID" value="ANIA_09234"/>
    </dbReference>
    <dbReference type="KEGG" id="ani:ANIA_09234"/>
    <dbReference type="eggNOG" id="ENOG502SPEU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046730_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AR46"/>
    <dbReference type="OMA" id="PGYSWYW"/>
    <dbReference type="OrthoDB" id="5295747at2759"/>
    <dbReference type="BioCyc" id="MetaCyc:MONOMER-124181"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.370.10">
        <property type="entry name" value="AttH-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023374">
        <property type="entry name" value="AttH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010791">
        <property type="entry name" value="AttH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053112">
        <property type="entry name" value="Fungal_Dehydratase/Hydratase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40617:SF1">
        <property type="entry name" value="ATTH DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40617">
        <property type="entry name" value="TERPENE CYCLASE ASQC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07143">
        <property type="entry name" value="CrtC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159245">
        <property type="entry name" value="AttH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007924299" description="Dehydratase asqC">
        <location>
            <begin position="19"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="215"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="264"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="25251934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="28114276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="5">
        <source>
            <dbReference type="PubMed" id="25251934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="6"/>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAA61525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005890"/>
        </source>
    </evidence>
    <sequence length="347" mass="37948" checksum="B7C721D5547994EB" modified="2005-04-26" version="1" precursor="true">MRPAILAAFSTLPAAAKATYPFAPETFDGSYKDIGLPTIYDLSATQSTNYNGSWATGSWITSVSGGQYFVVSHYVNDGIHDVYRSSILDLSSLKYRYFFQAGNGSYTASPPSHLKAGVGKGNGFEGISNDNYTTMRVQSSHPNVTFDLTYHATTKPLINGGAGVVMLGASESKQWSLPACWTNGFLIVGDEQIPIDPKRSLTWYDRQWGTGGLTNWTWYGLHIPKTGHVLSIWTGDTDADRAAPITPVRFATVRNAYGAQTVCNITWIPDLSHIFHSDSTNKSYPLAWTVEIPSYDAIIKVKSRTENQLNTGSHGSEPEAYNGFVTFAGQFQGTETEGFGIVEIVYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="107" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AR97</accession>
    <accession>C8VJV2</accession>
    <name>Q5AR97_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Beta-1,4-glucosidase (Eurofung)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_09183</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF82369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_682452.1">
        <property type="nucleotide sequence ID" value="XM_677360.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AR97"/>
    <dbReference type="STRING" id="227321.Q5AR97"/>
    <dbReference type="CAZy" id="GH1">
        <property type="family name" value="Glycoside Hydrolase Family 1"/>
    </dbReference>
    <dbReference type="GeneID" id="2868120"/>
    <dbReference type="KEGG" id="ani:ANIA_09183"/>
    <dbReference type="eggNOG" id="KOG0626">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001859_1_3_1"/>
    <dbReference type="InParanoid" id="Q5AR97"/>
    <dbReference type="OMA" id="HAQVYHF"/>
    <dbReference type="OrthoDB" id="65569at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000182">
        <property type="entry name" value="Beta-glucosidase 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001360">
        <property type="entry name" value="Glyco_hydro_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353:SF53">
        <property type="entry name" value="BETA-1,4-GLUCOSIDASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00232">
        <property type="entry name" value="Glyco_hydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00131">
        <property type="entry name" value="GLHYDRLASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013266142" evidence="2">
        <location>
            <begin position="16"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF82369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="581" mass="65549" checksum="17E5655703D26403" modified="2005-04-26" version="1">MRARVILAFAVGVQGQQLYITTTGYSARPECTAAPATPSYRFEPFQYTLNETIRWLPGETVISATDTEDKYGQAAWSSQWQAASLINYTTVGLYTTTVSPTPIPSSELVLPPRDYFGPTDCYDFPEDFMFGVAGSAAQIEGAIALEGRAPTNQEKLVQDDRPKNYVTNENYYLYKQDIQRLAAMGVKYYSFSIPWTRILPFAVPGSPVNQQAIQHYDDLINYILEVGMLPVVTMIHFDSPLYFLEGSSVSATPDVGASNGGYWHPEFVKSFVNYGKILFTHYADRVPVWVTFNEPLLYSFNFTGIHNVVQAHAELYHYYHEELGGTGKVGFKLNNNFGVPKNPENQTDINAANRFNEMQLGAFGNPLCLGEQYPETLLNTLPGAQKLTEAQLDYMANTTDFFGIDPYTATVVSAPPGGIETCAKQNMSTNSLYPYCVTQETTNIYGWDIGYRSQSYVYITPKYLRSYLYYLWNTFRTPVLIGEFGFPVYAESERELQDQVFDSPRSQYYLSYLSETLKAIWEDGVHVAGAFAWSFADNWEFGDYASQFGIQVVNRTTLERVYKKSFFDVVDFVGARNGLGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="139" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ARJ7</accession>
    <accession>C8VH64</accession>
    <name>Q5ARJ7_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">adenine phosphoribosyltransferase</fullName>
            <ecNumber evidence="7">2.4.2.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">ANIA_09083</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>AMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + adenine</text>
            <dbReference type="Rhea" id="RHEA:16609"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.4.2.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.7" evidence="7"/>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF82585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_682352.1">
        <property type="nucleotide sequence ID" value="XM_677260.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ARJ7"/>
    <dbReference type="FunCoup" id="Q5ARJ7">
        <property type="interactions" value="584"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5ARJ7"/>
    <dbReference type="GeneID" id="2868092"/>
    <dbReference type="KEGG" id="ani:ANIA_09083"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN9083"/>
    <dbReference type="eggNOG" id="KOG1712">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063339_1_0_1"/>
    <dbReference type="InParanoid" id="Q5ARJ7"/>
    <dbReference type="OMA" id="QAYDLEY"/>
    <dbReference type="OrthoDB" id="363185at2759"/>
    <dbReference type="UniPathway" id="UPA00588">
        <property type="reaction ID" value="UER00646"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002055">
        <property type="term" value="F:adenine binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003999">
        <property type="term" value="F:adenine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006168">
        <property type="term" value="P:adenine salvage"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000004">
        <property type="entry name" value="Adenine phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00004">
        <property type="entry name" value="Aden_phosphoribosyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005764">
        <property type="entry name" value="Ade_phspho_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050054">
        <property type="entry name" value="UPRTase/APRTase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01090">
        <property type="entry name" value="apt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002636">
        <property type="entry name" value="PRK02304.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32315">
        <property type="entry name" value="ADENINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32315:SF3">
        <property type="entry name" value="ADENINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 14" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="13">
        <location>
            <begin position="70"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00011893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CBF82585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="214" mass="22939" checksum="01EB697653AD2360" modified="2005-04-26" version="1">MSQHTASTSPDASSTTQVAGHPSSATSRAAELASLKVKLRGALRQFPDFPSPGILFEDILPIFSDHSTHEALVRCLELHILETLADEKPDVIVGLEARGFLMGPSLALKLGAGFVPVRKRGKLPGPCETQGYEKEYGQDFFQMQSDAIKPGQKVIVIDDIIATGGSAYAAGELIKKMGGNVLGFVFLLELEFLHGRDKLSAPVHTLLTGQETKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AT06</accession>
    <accession>C8VEU5</accession>
    <name>Q5AT06_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_08574</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF80828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_681843.1">
        <property type="nucleotide sequence ID" value="XM_676751.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AT06"/>
    <dbReference type="GeneID" id="2868646"/>
    <dbReference type="KEGG" id="ani:ANIA_08574"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN8574"/>
    <dbReference type="HOGENOM" id="CLU_1820352_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AT06"/>
    <dbReference type="OMA" id="YKSANME"/>
    <dbReference type="OrthoDB" id="10557503at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="83"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="129"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF80828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="176" mass="21240" checksum="3E9899846CF941E7" modified="2005-04-26" version="1">MLACGVAWQVWLIANQRRIMISYVTYLQDSIIFLSLIEAVQNSAKLDKQDIIQYQNRDYFGVHHSYRTANMEANYLRHLAREESRKRRRSSSAHLSSQFDRRSQTRPRITRSPSESFQSPSVNILSFEEQRQALELRQIEIKLRREEEEVRALQLQNEEKELEFMERRRRLQEFDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AT44</accession>
    <accession>C8VEQ3</accession>
    <name>Q5AT44_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ANIA_08536</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF80750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_681805.1">
        <property type="nucleotide sequence ID" value="XM_676713.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AT44"/>
    <dbReference type="STRING" id="227321.Q5AT44"/>
    <dbReference type="GeneID" id="2868874"/>
    <dbReference type="KEGG" id="ani:ANIA_08536"/>
    <dbReference type="eggNOG" id="ENOG502SMU6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041307_1_2_1"/>
    <dbReference type="InParanoid" id="Q5AT44"/>
    <dbReference type="OMA" id="WSCFKIK"/>
    <dbReference type="OrthoDB" id="5207033at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="298"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="330"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBF80750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="412" mass="48642" checksum="DFF405420D941837" modified="2005-04-26" version="1">MTAVEMGTVNSRPLVQIFEEIGPDRWEDREPDLNILESRPEANFLVLLSNEFREYAKEHMPEFKNKFLDEFWPVLEDDINGSFHCEYNDSNARVTPAVTWSCFKIKEVKTAGEYKWKQPAIHVDWNADTGRHVVHVIEPPLQRPSEFLPRIPPAEERRCNPFSWHAAFARMVLEQYDRAFWLLRDLVRKQEKERSESAHKPNDFPHLHDILRHLFHYEETIEVAQHTLRMMAAEKDRWRNEDEEDIRQNLGIWIKTRQRILHEEKRAHSLKTRSKSLNDRHRNEINLVTHLAQQVSMVYLPGTFVSGLFGTNFFSFQADPGNTWLMADEFWLYWAVTLPLTFATVVIWAIWHWQDKFVFLRNKAQGQRSNTSAGFTNSRGNLESNDRPNITFLRRMTTALGWGEGVQRVETV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ATL2</accession>
    <accession>C8VE63</accession>
    <name>Q5ATL2_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Spherulin 4-like cell surface protein, putative (AFU_orthologue AFUA_4G14080)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_08368</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF80398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_681637.1">
        <property type="nucleotide sequence ID" value="XM_676545.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ATL2"/>
    <dbReference type="STRING" id="227321.Q5ATL2"/>
    <dbReference type="GeneID" id="2868776"/>
    <dbReference type="KEGG" id="ani:ANIA_08368"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN8368"/>
    <dbReference type="eggNOG" id="ENOG502S3WN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060605_0_0_1"/>
    <dbReference type="InParanoid" id="Q5ATL2"/>
    <dbReference type="OMA" id="AMHGIFF"/>
    <dbReference type="OrthoDB" id="5342184at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021986">
        <property type="entry name" value="Spherulin4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35040:SF9">
        <property type="entry name" value="4-LIKE CELL SURFACE PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14080)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12138">
        <property type="entry name" value="Spherulin4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF80398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="305" mass="33928" checksum="A3BD92C01425649C" modified="2005-04-26" version="1">MESLKHTQEGSNPVSRLRKCDLRRRWWITIGVVVAIAVILAVVIPLALILPNRGDKGEPSSVIFPLYIYPETDSTWAPLYDAIAAHPDLQFLLVVNPSSGPGDSSTPDEAYQTAIRQLNTYANVQKIGYVRTNYAQRNVSEVLADISTYSGWPSQSADLAVTGIFFDESPHQYAAETVEYLERINAAVINASGIGGDKTIIHNPGTLPDSQLVLNTTSITVVFEQSYDHYKTSQESRLSAVADSADRDSWAYIFHSVPQMGNSNMDSFVREISRQAAYLYATTRSTEYYEHFDTRLEEFCDAVPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ATW8</accession>
    <accession>C8V3N4</accession>
    <name>Q5ATW8_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">cAMP receptor-like protein, putative (AFU_orthologue AFUA_5G04135)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ANIA_08262</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="CBF74235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="XP_681531.1">
        <property type="nucleotide sequence ID" value="XM_676439.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ATW8"/>
    <dbReference type="STRING" id="227321.Q5ATW8"/>
    <dbReference type="GeneID" id="2869330"/>
    <dbReference type="KEGG" id="ani:ANIA_08262"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN8262"/>
    <dbReference type="eggNOG" id="ENOG502QTGV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024810_3_1_1"/>
    <dbReference type="InParanoid" id="Q5ATW8"/>
    <dbReference type="OMA" id="RMEIPYL"/>
    <dbReference type="OrthoDB" id="18453at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031669">
        <property type="term" value="P:cellular response to nutrient levels"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043942">
        <property type="term" value="P:negative regulation of sexual sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="AspGD"/>
    </dbReference>
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        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR 157-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05462">
        <property type="entry name" value="Dicty_CAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="46"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="164"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="308"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="344"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="6">
        <location>
            <begin position="8"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBF74235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="404" mass="45914" checksum="753CF7953F8C897E" modified="2005-04-26" version="1">MSLSAGQLFAISATERTCSTVSLFATSIIIVSFVSSQSFRKPINRLVFYASFGNIMANVATLISQSGIWAGTDSNLCQIQAFLIQWFMPADALWTFAMAFNVYLTFFRKYNSDQLRRLEWKYVMLCYGLPFIPAFTYFFIRTESRGKVYGSAILWCWVAPSWDFLRIAVFYGPVWFVIFVTLAIYARIGELVWRRRRQLKEVGGLDTTLDVSIPDDPPFSKVTEIRIEREDAASYRPEAGPSTEQDPPFSCAQSIPRPYSVNVQAGSSQLELGAIRSEEPFDGPPTREYRSSSTALEVNTAAWAYTKYAMLFFVALLVTWVPSTINRVYAFIRPDASNFGLNYASSFVLPLQGFWNSLIYISISWRCFKPALSDLHNRLLWYTHLGAGHRRPSSGQDSTRRLTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="141" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ATY0</accession>
    <accession>C8V7H6</accession>
    <name>Q5ATY0_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Cytochrome P450, putative (Eurofung)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">ANIA_08250</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF74206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_681519.1">
        <property type="nucleotide sequence ID" value="XM_676427.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ATY0"/>
    <dbReference type="GeneID" id="2869211"/>
    <dbReference type="KEGG" id="ani:ANIA_08250"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN8250"/>
    <dbReference type="eggNOG" id="KOG0157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022195_9_0_1"/>
    <dbReference type="InParanoid" id="Q5ATY0"/>
    <dbReference type="OMA" id="HTFLNCV"/>
    <dbReference type="OrthoDB" id="1844152at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd11041">
        <property type="entry name" value="CYP503A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206:SF1">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-0349">Heme</keyword>
    <keyword evidence="9 12" id="KW-0408">Iron</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="290"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="453"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CBF74206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="510" mass="58088" checksum="E229EF46EAE002EA" modified="2005-04-26" version="1">MSTAWTNSWIAIAVTTFLVAVFVLLYSAPQSEIDIPLVRDRGRKRFRTSTFVSYLFNANDILQEAYDTYLKHGKTCRVPDKSLGTMILIPNRYMKWMLSQPTGVLNSYEAIAEIVQARWTLGDTRYLSDDWHLNMLRDALRPLSKSGIVEFQEELERSMEDVLGNDHVNWKDVNPTIATKRIILQATTRYLVGSPLCADEQFLRWILIFIEWITPVGELLRLTPRGLRSVVGHIFSIPRFIVIQKLKAILRPQYDKRLSFIRSGQSPEDGPQDLLQMMMRDLYERNSTDLNLHFITINVLVFVIAAVVQTYMLAPSVLYDILESNAEYNTISKLQEELVCVLGEPAQGQRWSQNEARQMAKLDSVLRESLRTNTLVSQTMPRKVMVDSLQTPDGITLPRGATVALLARAAQTDPDIYPNPNKFIPFRHAVPGGKQFAATGENFLAFGHAKHACPGRFLVSVELKMLVAHILRHYHIELPAEYGGKRPKAVWFTDLNLPPQHGVIRVKRCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="144" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AU80</accession>
    <accession>C8V6V8</accession>
    <name>Q5AU80_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">ABC multidrug transporter (Eurofung)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">ANIA_08150</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF73982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_681419.1">
        <property type="nucleotide sequence ID" value="XM_676327.1"/>
    </dbReference>
    <dbReference type="GeneID" id="2869298"/>
    <dbReference type="KEGG" id="ani:ANIA_08150"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN8150"/>
    <dbReference type="eggNOG" id="KOG0054">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_238771_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AU80"/>
    <dbReference type="OMA" id="EYCNYAD"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd18579">
        <property type="entry name" value="ABC_6TM_ABCC_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18580">
        <property type="entry name" value="ABC_6TM_ABCC_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000055">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000296">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044746">
        <property type="entry name" value="ABCC_6TM_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044726">
        <property type="entry name" value="ABCC_6TM_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF404">
        <property type="entry name" value="ABC MULTIDRUG TRANSPORTER (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="125"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="268"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="363"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="412"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="445"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="477"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="506"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="542"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="603"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="693"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="727"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="821"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1363"/>
            <end position="1383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1450"/>
            <end position="1470"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="696"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="974"/>
            <end position="1190"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="1296"/>
            <end position="1505"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="1545"/>
            <end position="1761"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1189"/>
            <end position="1244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1189"/>
            <end position="1206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1214"/>
            <end position="1224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CBF73982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="1773" mass="193825" checksum="6A98AA27BB1CCFE6" modified="2005-04-26" version="1">MSASETTPLLPPSPTLSPSFSSIDKEKNNRFVFYVCLITLFIINGGGSMSVPPTTSILQDLLCERHYAQRGLTRPGTDELDCKIEPVQSSLSMLRGVVGLLALLPGLLLGVPYAALAENWGIKRVLLLSVTGIILCDVWFSLICWFGRNLPLQLIYLTPLGYLVGGGPSVGGSLLPTRFFLMEAAAYSGAVLGYTASSAIMNTHLWASVVLGPCLVFSTFFLVLLFPNDCPIGAKARPDAGPDPAPAPEAKSMLHTMRTAMVLFKGQIGLVIILLGYALRCLGDGVMALLIIYASQVFDWSFSQSGYLLSLQNATHLVVLLILPVVDRLLAQYLGRARQTEHEFIEPATGLAKHFSLARGSALLSAIGSAGMALFRSPFLFVISVILYGFGSGYNQSIRSIMTLSTPEEHRAITYSVLGIMEAAGNLVGAPFWPFIYQIGLKGDGYWVGLPFVVTAGLMAAVWVMLRIPNLSPRGPIPALIAIHIASFGMRLVVSSDRRSWLRSLYGLFMLQASLISLTALFIPQIVFLSERELRSPTLRNAVSLPADILELLATAAALVLSYIHHCRSLRPSTLLILFLSARSPLGIARVRTLWLIPGANRAAILFTAGFVATLLCAILESTEKTSNILPARKIGKAIPATPESFSGLWKCASFAWLSGTFRRGYVHVLSVDDLPQLDPALDSEVVRERLEYIWATTGFAFCQPFLINATVSWVGRPDAPADSGKALIGAFALVYVGQAVCTALYGYQNIRFIIRLRGGLISLIHKQTVHPRAVDLGGSTAITLMGTDVERIVSGFRLLHELWPSLTEIGIAVYLLERQVGVACLAPAVIVAVFILATFKLSTLTNKFQRLWIEKVEDRLGLTSYTLENIKAVKMLGLSEKIFSIVQGLRHAEIATSAVFRKLLIGTITLSNSPSDLAPMTTFAIYVIIALVRNDNSILAAQAFTSLSLISRYEPGADDMPAVAEGEEQKMLVTFNRYTVTWEKSVAPVLREISLTINHGITMITGSIGSGKSTLLESILGETLVTSGHADWVYRGSVAYCSQTQWLQSQSIKANIVGRSLPDETWYRTVISACGLEKDLSRLPRGDATAVGNNGMTLSGGQKQRIVCPPIPSLDLRAVFQSAYADSGQALSRALYSRAQIILLDDVFSGYLLRYADEIVVLESGQLVDKGSLEDLMAKSTYIQGLQTSLPKPTSSIDSRSSETVMATPFSVEQDRTAEERANEAVPSENDDLLGHEAPSDPTRLLTGVQQSGSTGGQRQMPDSKCPGGHVSRCLRASGHIWNDSYDHGVSSALKLHNDLVDNTARASLQFFQRVDIGSITNRFSQDLDLVDMSLPLDALSCLAAVCTCVLKLLILCVSAKYLAVTIPFILITIYFTQSLYLRTSRQMRLLDIEAKAPLYTHFTELVSGAATIRAFRWHASSQRSALKLLNLSQRPVYFQYCIQKCLGFVLDLLVAVLAVILVATVVLLRDKFQAGDVGVALVTVMTFNSSLMNLVRFWTEMETSIGAVKRVKNYVKTAEPEEDDVSQARLAELPYSWPEKGDIRFEGVMAGHLPSSPPILKDLTLSMSPGSRVAIKGSMMIDGLDLKAYRREEIRKRLNIITQNPFLVSGSVRFNIDPWGNAPDKRIVAALKRVGLWDVIVQQESGRDSFSGLDMQINANVFSAGQRQLLCLARALVRPGKVLILDEATSSVDNATESTMQSILETEFASYTILSVLHRFRYIHHYDEVAVLEAGRLVEFDEPGILLKREGSRYRELYRSGEYNGNDANGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AV09</accession>
    <accession>C8V3M8</accession>
    <name>Q5AV09_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Asl1-like glycosyl hydrolase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_07871</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF73424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_681140.1">
        <property type="nucleotide sequence ID" value="XM_676048.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AV09"/>
    <dbReference type="CAZy" id="GH128">
        <property type="family name" value="Glycoside Hydrolase Family 128"/>
    </dbReference>
    <dbReference type="GeneID" id="2869151"/>
    <dbReference type="KEGG" id="ani:ANIA_07871"/>
    <dbReference type="eggNOG" id="ENOG502RXK9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040908_4_0_1"/>
    <dbReference type="InParanoid" id="Q5AV09"/>
    <dbReference type="OMA" id="ERYAYHM"/>
    <dbReference type="OrthoDB" id="43654at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071966">
        <property type="term" value="P:fungal-type cell wall polysaccharide metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053183">
        <property type="entry name" value="ASL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024655">
        <property type="entry name" value="Asl1_glyco_hydro_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34154">
        <property type="entry name" value="ALKALI-SENSITIVE LINKAGE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34154:SF11">
        <property type="entry name" value="ASL1-LIKE GLYCOSYL HYDROLASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11790">
        <property type="entry name" value="Glyco_hydro_cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010317654" description="Asl1-like glycosyl hydrolase catalytic domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="Asl1-like glycosyl hydrolase catalytic" evidence="2">
        <location>
            <begin position="25"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF73424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="234" mass="26036" checksum="1EFB096FCBA70657" modified="2005-04-26" version="1">MAFKTASFVLYLLGPTLTFAQEKRGLAYNDGALANLFSGHSQVSWGYNWGSDGNGLDTALNFTPMLWGLASRLSPEWTAAVEGEGVEAILGFNEPDLDAHSNITPSDASRRIPVTNGSPPNMGIGWMDQFFEHCTTCTIDFVTIHWYANNDPQGFKSHVQQFYDKYRLPIWITEFAASGSEEEQISFLQAVLPWLDSQPYVERYAYFGVFPGFLVNENGDGLSRLGQVYATCSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AV83</accession>
    <accession>C8VDR8</accession>
    <name>Q5AV83_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">C4-dicarboxylate transporter/malic acid transport protein, putative (AFU_orthologue AFUA_2G17660)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ANIA_07797</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF80127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_681066.1">
        <property type="nucleotide sequence ID" value="XM_675974.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AV83"/>
    <dbReference type="STRING" id="227321.Q5AV83"/>
    <dbReference type="GeneID" id="2869415"/>
    <dbReference type="KEGG" id="ani:ANIA_07797"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN7797"/>
    <dbReference type="eggNOG" id="ENOG502QV03">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030057_2_0_1"/>
    <dbReference type="InParanoid" id="Q5AV83"/>
    <dbReference type="OMA" id="WIYYACE"/>
    <dbReference type="OrthoDB" id="2901184at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015140">
        <property type="term" value="F:malate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd09317">
        <property type="entry name" value="TDT_Mae1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.150">
        <property type="entry name" value="Voltage-dependent anion channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030185">
        <property type="entry name" value="Mae1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004695">
        <property type="entry name" value="SLAC1/Mae1/Ssu1/TehA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038665">
        <property type="entry name" value="Voltage-dep_anion_channel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31162">
        <property type="entry name" value="MALIC ACID TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31162:SF1">
        <property type="entry name" value="TRANSPORTER_MALIC ACID TRANSPORT PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G17660)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03595">
        <property type="entry name" value="SLAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="113"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="224"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="262"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="316"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="343"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBF80127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="375" mass="40638" checksum="C9953A6D1E709240" modified="2005-04-26" version="1">MEKRLSLRQRLSQATWGWYSASMATGGIAVLLYNTPHQFTGLETIGKIVYIFNIVLFVGISLCMVVRFCSSPPALKESVRDPSETHFIATCPLAVATIILGASSYGTDACGPWLLAALHAVFWVYVTASVVQAIAHNWYLYHRRMASQQPMAIVRCLPSFPAMLSGTIAAGLASDQPAGRAVPMIIAGTTLQGFGFVMTLFVYSEYFYRLNKDGLPDLHDRPEMFIAVGPWSFTALALIGMAEAAVEKVPAGYIVSSATDTAVAVATGQIALVLASLVAIFLWMLALYCLCIAILSMLAPCRALGGEGRVPMSLAYWSMVFPNTGFVIATIRIGQVLQSEPVLWVASAMTIVQVGTWLGVGLVTMWKIVHAFMYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="113" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AWV2</accession>
    <accession>C8VCY4</accession>
    <name>Q5AWV2_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Flavin-binding monooxygenase, putative (AFU_orthologue AFUA_2G17490)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ANIA_07228</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF78809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_680497.1">
        <property type="nucleotide sequence ID" value="XM_675405.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AWV2"/>
    <dbReference type="GeneID" id="2870071"/>
    <dbReference type="KEGG" id="ani:ANIA_07228"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN7228"/>
    <dbReference type="eggNOG" id="KOG1399">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006937_7_1_1"/>
    <dbReference type="InParanoid" id="Q5AWV2"/>
    <dbReference type="OMA" id="KELIWEM"/>
    <dbReference type="OrthoDB" id="74360at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051209">
        <property type="entry name" value="FAD-bind_Monooxygenase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877:SF4">
        <property type="entry name" value="FAD_NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBF78809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="565" mass="63297" checksum="F9A2EA7BBBCC2948" modified="2005-04-26" version="1">MGSATINQPVGNTDYTQSTVAIIGAGISGMCMAIDLLRRNHRNFVILEKGSSVGGTWNDNKYPGCACDVWSALYSYSFEQRSTWTREYPGQEEILHYLTGIAGKYGLYPHIRFNSTVEEARWDDEARKWKIKVSVSGAKDAQFQEGYELSANVLISGVGQLNQPAWPNIDGMNEFKGKSMHSARWDWTYDFKGKRIAVIGNGATATQIVPEVAKTASHLTVYQRTPQWIIPRDDKPVHPAQKALLSFPFFRNCKRSFMMLYREMSHDFIVKSDAKNSQEVRELCIGHIKKGLPSKPELWDVLTPSYPPGCRRILASDDYYPALGRENVKLDTRNIQRITETGIQTADGETTDFDLIVYATGFRTVEFLHPIKVYGAGGRDLAEIWDGGATAYYGVTVEEMPNFGLLYGPNTNLGHNSIILMIEAQSRYLAALIDPVIRAKEAGVSLAIQPKTEIVRAFNADIQKRLGKSNFADPACNSWYKTADGRITNNWPGTVVEYQQALSRVRWTDYIVDEETMKFVGKNETRIGHVEEVWPVSKSTLLLGLSVAVAAGGWYLQGARASRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="112" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AWY7</accession>
    <accession>C8VD29</accession>
    <name>Q5AWY7_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">D-xylose reductase [NAD(P)H]</fullName>
            <ecNumber evidence="3">1.1.1.307</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">ANIA_07193</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the initial reaction in the xylose utilization pathway by reducing D-xylose into xylitol. Xylose is a major component of hemicelluloses such as xylan. Most fungi utilize D-xylose via three enzymatic reactions, xylose reductase (XR), xylitol dehydrogenase (XDH), and xylulokinase, to form xylulose 5-phosphate, which enters pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>xylitol + NAD(+) = D-xylose + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27441"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17151"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.307"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>xylitol + NADP(+) = D-xylose + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27445"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17151"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.307"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate metabolism; D-xylose degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.307" evidence="3"/>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF78891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_664797.1">
        <property type="nucleotide sequence ID" value="XM_659705.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AWY7"/>
    <dbReference type="STRING" id="227321.Q5AWY7"/>
    <dbReference type="GeneID" id="2870144"/>
    <dbReference type="KEGG" id="ani:ANIA_07193"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN7193"/>
    <dbReference type="eggNOG" id="KOG1577">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AWY7"/>
    <dbReference type="OMA" id="LWNSQHH"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004032">
        <property type="term" value="F:aldose reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042732">
        <property type="term" value="P:D-xylose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000007">
        <property type="entry name" value="NAD(P)H-dependent D-xylose reductase xyl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0859">Xylose metabolism</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="13">
        <location>
            <begin position="18"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="12">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CBF78891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="334" mass="37265" checksum="00321F62493D3FF7" modified="2005-04-26" version="1">MSLGKKVTLNTGAQIPQLGFGTWQSAPGQVGEAVYQALKVGYRHLDLATIYQNQREVAEGIKRAYKDIPGLKREDIFITSKLWNTQHDPAVVEKALDDCLAELELDYLDLYLVHWPVAFKTGDNYFPLDESSDHPDGDVLIDDSISIVDTWKAMTKLPKEKARAIGVSNHTVEHLEAIINATGVVPAANQIERHPVLQSNDLIEYAAKKNIHITAYSAFGNNMFNIPLLVAHPEVKAVAEEASKRLGKTVTPAQVILNWSQEGGHSVIPKSVTASRIAENFQEVELTKEELAKVSKLGEERRRYNTPYVANKPRWNINIFGEEDEKPAKHKVIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AX65</accession>
    <accession>C8VDB7</accession>
    <name>Q5AX65_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RelA/SpoT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_07115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF79052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_664719.1">
        <property type="nucleotide sequence ID" value="XM_659627.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AX65"/>
    <dbReference type="STRING" id="227321.Q5AX65"/>
    <dbReference type="GeneID" id="2869816"/>
    <dbReference type="KEGG" id="ani:ANIA_07115"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN7115"/>
    <dbReference type="eggNOG" id="ENOG502S64P">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045995_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AX65"/>
    <dbReference type="OMA" id="FPGYCAD"/>
    <dbReference type="OrthoDB" id="4719016at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015969">
        <property type="term" value="P:guanosine tetraphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05399">
        <property type="entry name" value="NT_Rel-Spo_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007685">
        <property type="entry name" value="RelA_SpoT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41773">
        <property type="entry name" value="GTP PYROPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41773:SF1">
        <property type="entry name" value="RELA_SPOT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04607">
        <property type="entry name" value="RelA_SpoT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00954">
        <property type="entry name" value="RelA_SpoT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RelA/SpoT" evidence="1">
        <location>
            <begin position="58"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF79052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="456" mass="53120" checksum="D4A5CAD33174A0F2" modified="2005-04-26" version="1">MSSVGNTSSSIQDQETVIEQFQAWYEGHRSGYVSIAQESAGRLAQVLGDAGVPHKVEYRAKDIARLRIKVNGRKNDKRYGNVDDVATDIVDLAGVRVLLYFPSDKDRVEKLITENFEVHSSHRITGTKTIEIRRASHGYTPKYPTYCADHYRATLRLKEGREAEPWQSFRLEIQVTTILRHTWAEVGHDWSYKKLKPGGEDEFCCQLLDALSGAVDMGEFFLEQMQKRLMTQKEQADQPFRSHYELGEFLRRWAARNGRAQDLVDVQTLWQVLHYYDYDRPTELLQILAGLDLSSELAQKYEPLPFNLETSIIHSILVSDERYKRERETDAARPTKFQRYKLKVVRDCFIWFGRLFRFNHKWYSLLCSGSVPRRVLENMEWLVNQSMKEGETLSSGDERILDDLFDTFAKHGKLAVQYVFFLARLRVKAFPADGYAMRMVVQPLLKLRAHQRARLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AXC0</accession>
    <accession>C8VB43</accession>
    <name>Q5AXC0_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tyrosinase</fullName>
            <ecNumber evidence="3">1.14.18.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">ANIA_07060</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>2 L-dopa + O2 = 2 L-dopaquinone + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:34287"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57504"/>
            <dbReference type="ChEBI" id="CHEBI:57924"/>
            <dbReference type="EC" id="1.14.18.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-tyrosine + O2 = L-dopaquinone + H2O</text>
            <dbReference type="Rhea" id="RHEA:18117"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57924"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="EC" id="1.14.18.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tyrosinase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.18.1" evidence="3"/>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF79167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_664664.1">
        <property type="nucleotide sequence ID" value="XM_659572.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AXC0"/>
    <dbReference type="STRING" id="227321.Q5AXC0"/>
    <dbReference type="GeneID" id="2870197"/>
    <dbReference type="KEGG" id="ani:ANIA_07060"/>
    <dbReference type="eggNOG" id="ENOG502RYJI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013691_1_2_1"/>
    <dbReference type="InParanoid" id="Q5AXC0"/>
    <dbReference type="OMA" id="YTIVFYL"/>
    <dbReference type="OrthoDB" id="1658288at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004503">
        <property type="term" value="F:tyrosinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042438">
        <property type="term" value="P:melanin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.310.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050316">
        <property type="entry name" value="Tyrosinase/Hemocyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041640">
        <property type="entry name" value="Tyrosinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474:SF76">
        <property type="entry name" value="SHKT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474">
        <property type="entry name" value="TYROSINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18132">
        <property type="entry name" value="Tyrosinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00497">
        <property type="entry name" value="TYROSINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00498">
        <property type="entry name" value="TYROSINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0186">Copper</keyword>
    <keyword evidence="8" id="KW-0470">Melanin biosynthesis</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="11">
        <location>
            <begin position="90"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="12">
        <location>
            <begin position="384"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CBF79167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="674" mass="77686" checksum="A441FAF60725003A" modified="2005-04-26" version="1">MIVVRGIKTRDANGKPYLRQDIDKWYMEQMAGDRIQLTLFVEALALIQRRDLDDLKSYFRLAAIHSAPWCEWDDVPQAQREPGERGYCVHSNYTFPTWHRVYMMLYERTLYEAMLEWIHEAVPESHKDIWRKEADKWRLPYWDFARFADRPPSTAGPLPHDIDHDQLRLPILCMMPNVRITLFTKDSGPIIESRPNPLYKYITPQLMGEFRDPYKIRGETTEPDPNDKVQTPKFTLQWDKCNATTKYGLLDGFHESIWADGGQNWLRANYALNEHSNFEKLGENPVPTLQDLVHRLFQYGLDSWGAFSSVRYTKDSTKAESASTGIETYSEELDGNVKNALSLDFIHNNVHNFVGGSQFLRPPKEGIHLWGAGHMSSVAMAAFDPIFFIYHNNIDRLTAIWQILNWEKWFDDDKSKLIKDNALTPFHKDADRNFWKSDDEILKGIETLYGKPTENLYGLLPKHHGDSEDYVITVVYDKFALNGAPYKINLFLDGTRNFGGPDSKGFIASIYNFSGSLESCACGNCQRQKKDGVKCIAQVPATVPMRRFMGKTATAVQTTRDIRDEPKPVYLAVDSLGTPVQMDIHVELHKSRREYYKKPFQPDPNDPLEYNFLKHGKQAPDWAFASTRSSDRLEVYLISIPEARKVKSCLQELEVKKLGTHEGLWPNLTPELGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="99" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AXV0</accession>
    <accession>C8V2Q8</accession>
    <name>Q5AXV0_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Kinase</fullName>
            <ecNumber evidence="4">2.7.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ANIA_06880</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the inositol phosphokinase (IPK) family.</text>
    </comment>
    <dbReference type="EC" id="2.7.-.-" evidence="4"/>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF71651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_664484.1">
        <property type="nucleotide sequence ID" value="XM_659392.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q5AXV0">
        <property type="interactions" value="186"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5AXV0"/>
    <dbReference type="GeneID" id="2870582"/>
    <dbReference type="KEGG" id="ani:ANIA_06880"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN6880"/>
    <dbReference type="eggNOG" id="KOG1620">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001850_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AXV0"/>
    <dbReference type="OMA" id="SPTAHQW"/>
    <dbReference type="OrthoDB" id="2573163at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000824">
        <property type="term" value="F:inositol-1,4,5,6-tetrakisphosphate 3-kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008440">
        <property type="term" value="F:inositol-1,4,5-trisphosphate 3-kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.160">
        <property type="entry name" value="Inositol polyphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005522">
        <property type="entry name" value="IPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038286">
        <property type="entry name" value="IPK_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400:SF21">
        <property type="entry name" value="KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03770">
        <property type="entry name" value="IPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
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    </feature>
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    <feature type="region of interest" description="Disordered" evidence="5">
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
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            <begin position="725"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
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    <feature type="region of interest" description="Disordered" evidence="5">
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    <feature type="region of interest" description="Disordered" evidence="5">
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            <begin position="1"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
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            <dbReference type="ARBA" id="ARBA00007374"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBF71651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="1357" mass="151364" checksum="0BC97915296CB5E7" modified="2005-04-26" version="1">MSRPPSASETTPSTPPVTPAASAQHDCSGRPSSLHSKQRRHRDVRDQLVHIDPQHVPSPSRAESPTARQWANPSSNSTLKRAKTTASDTLSRPGLSYTGYNSPQLSERDSIFATHYLPSDNEAASSPQLPPVEAAYHDVPSKLNSDNASPSSFTPKALSYQHRGDDAHMEVDVRRTQPLRSAPLLPSDTPFTISPSDSDVGLDEDLDSSTRRPQKHTLDNIAPYRKSSLHLPGAGAAASAPPHGLHPSPVIDGTSRPQELMVTSDKRATNASPGGSSHQKQGQSPWDFAKGPKVERSSSRSRRGRVENSIEADITNAEHAPYVRSRKSSHYLGLFKENTATSPDRKRRDDRSARHDNSSESRGREQHGPHAEHRHSRDDQYEADSFKRPEVQGSKRLSQLSLANIPMIKPFAGGDSQEDYTAEHVPAKSEQKRLPRSLLEEIRNFHLTPGGARGTSFSRSIPTQYSERSKAFHPRSPFSDTEEPHVGSGPLDDEEDEQISSAVYFPHERVTVSGEVDPLQSIEVHPRDLHSFDESATEGSLVLKPERLTAPDEPETNHVDISLRSKNDSRILHGDLQDRKTPIEELNEKSIDSMLQRQTEYSTEESEAFSADDSGTSVRDEESSVTDEAEVTPTATPTQRPHIPRPRRKQGAVTPVGAVELKPYRHQVGGHTTVFRFSRRAVCKQLNNRENEFYERIERRHPEMLMFLPRYIGVLNVTFSKKRSKKSSEAQLEQSDVDATDDPQNKNTVATTGHSLHEAANSVEKERIFSQKQVTGIVPKVILENNRHIIPVDLFSHKRPRTATAALSDMRPSSNGAGRTTNQRNHEHGSLDEKLSHSPAKKTWGATTVNRKLQEQVLREVFSPPAIHHHRRHARGLLNLPRTTSDGHRRSANLSEGLITRQPRIMEQMEPPRSPAIDIVKKGSDGPGLSSSASTALEGGQQHLESVRSEEAVPRSSSVSRTRRVRRRHSGSGLQRRGTMDSDKGGGELIFFEDEGYGGDKEDEIFSMESDAPTSSTTPGEARLSSSSPSKGSDLIPQDRWTSGGPVVESSKSPAFPGFNDNILSQPPANPKEAQTRKDDRVQFFLLLEDLTAGMNKPCVLDLKMGTRQYGVEADDKKRKSQRRKCQNTTSQQLGVRLCGMQTWNVKKQEYIFEDKYFGRDLKSGREFQDALTRFLYDGVSYLSVAKKIPIILDKLAKLENMIRKLKRYRLYASSLLILYDGEQNPQHKASQHEAASNDNARNHLQRRTSEDGHNNTDVSLKIVDFANCVTGEDELSPNARCPPQHPDDIDRGYLRGLRTLRMYFQRIMKEVSQDEYLERGEGEGIALNPQSSSNNPTSDRYWDESVMDQDPGEVSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AY64</accession>
    <accession>C8V255</accession>
    <name>Q5AY64_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ANIA_06766</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF71416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_664370.1">
        <property type="nucleotide sequence ID" value="XM_659278.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AY64"/>
    <dbReference type="STRING" id="227321.Q5AY64"/>
    <dbReference type="GeneID" id="2870295"/>
    <dbReference type="KEGG" id="ani:ANIA_06766"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN6766"/>
    <dbReference type="eggNOG" id="KOG1176">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_59_11_1"/>
    <dbReference type="InParanoid" id="Q5AY64"/>
    <dbReference type="OMA" id="YMRMMRY"/>
    <dbReference type="OrthoDB" id="2962993at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001676">
        <property type="term" value="P:long-chain fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201:SF8">
        <property type="entry name" value="ACYL-COA SYNTHETASE FAMILY MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="2">
        <location>
            <begin position="80"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="3">
        <location>
            <begin position="466"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBF71416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="579" mass="63251" checksum="9D3C4CC64C555C20" modified="2005-04-26" version="1">MAGKLATPGDRTLTVPLHKGDTVLPNLPFFEKLLRYAHRRPPTISIRDVHAGVEKGYTQLLTDALALRRALRGRLRPETLRDLNNDHEVFVAVIAPGGYEYTMAFTAILALGAAVVPITPALPVQEAKSLVTRAQCVAVISTSEVVPLAHGIIQSIVASNPATELPHLVTSQYLQSDSLPPSSITISSDPVPNMNMAALVIFTSGTTGPPKGAVQRRSYITSAAEDVADHYRLTESDTVLHMLPVHHATGIGVTFLPFLVVGGCIEFRSGGFDPEWTWERFRQNANPTGAKALSVFSGVPTIYTRLKRYFEIHISPLPSIEQEQYIAGVRRIRVFLCGTSALPRPIQEFWTRILDGKMILTRYGGTEFHTTLKADLDGSSPANSVGRVSPGVDLRLSDEGEILVKGPNMFSKYLHDTNATSKAHDKDGYFKTGDIASCMGESYFIQGRASLDIIKSGGYKISALDIEREILGLDYVSEVMIVGVEDEEFGQRVAAVVTLKDEHRASGLSLEKLRGDLRGVLAGYKMPTVLRVAGGEIPKGATGKVQKKVLGPRYFPDGWRGLEEVQVWDPQKMQPKSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="138" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AYG1</accession>
    <accession>C8V1F8</accession>
    <accession>Q2HQT5</accession>
    <name>Q5AYG1_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ANIA_06669</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF71215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_664273.1">
        <property type="nucleotide sequence ID" value="XM_659181.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AYG1"/>
    <dbReference type="FunCoup" id="Q5AYG1">
        <property type="interactions" value="196"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5AYG1"/>
    <dbReference type="GeneID" id="2870454"/>
    <dbReference type="KEGG" id="ani:ANIA_06669"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN6669"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_1_1"/>
    <dbReference type="InParanoid" id="Q5AYG1"/>
    <dbReference type="OMA" id="TFAADMG"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005358">
        <property type="term" value="F:high-affinity D-glucose:proton symporter activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904659">
        <property type="term" value="P:D-glucose transmembrane transport"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="CDD" id="cd17356">
        <property type="entry name" value="MFS_HXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000180">
        <property type="entry name" value="MFS monosaccharide transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF6">
        <property type="entry name" value="MSTA PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="307"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="331"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="361"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="393"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="427"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="462"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="22"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBF71215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="534" mass="58602" checksum="9110B0B154C12E5B" modified="2005-04-26" version="1">MADGVVAGTRVEAPVTWKTYLMCAFAAFGGIFFGYDSGYINGVMAMDYFIHEFSGKVKAEYEAADNLSGYVISSSNKSLITSILSAGTFFGAIIAGDLADWFGRRTTIISGCGIFMVGVALQTASTTVALLVVGRLIAGFGVGFVSAILILYMSEIAPRKVRGAIVSGYQFCVTVGLMLASCVDYGTENRTDSGSYRIPIGLQLLWAIILAVGLFLLPESPRYYVRKGDVSSAAKVLARVRDQDVESDYVKEELAEIVANNEYEMSLIPQGGYFATWFNCFRGSIWSPNSNLRRTILGTSLQMMQQWTGVNFVFYFGTTFFTNLGTISDPFLISMITTIVNVFSTPISFYTMEKIGRRPLLLWGALGMVICQFIVAIAGVVDGSNNKTVSAQIAFICIYIFFFASTWGPGAWVVIGEIYPLPIRSRGVALSTASNWLWNCIIAVITPYMVDEDKGNLKSKVFFIWGSLCACAFVYTYFLIPETKGLTLEQVDKMMEETTPRTSSKWKPHGTFAAEMGMTEKDVTQTVEDIAKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="110" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AZ78</accession>
    <accession>C8V0N4</accession>
    <name>Q5AZ78_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">catechol O-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ANIA_06402</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.6" evidence="1"/>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF69540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_664006.1">
        <property type="nucleotide sequence ID" value="XM_658914.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AZ78"/>
    <dbReference type="STRING" id="227321.Q5AZ78"/>
    <dbReference type="GeneID" id="2871298"/>
    <dbReference type="KEGG" id="ani:ANIA_06402"/>
    <dbReference type="eggNOG" id="KOG1663">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_344827_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AZ78"/>
    <dbReference type="OMA" id="ANCAQVE"/>
    <dbReference type="OrthoDB" id="186626at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006584">
        <property type="term" value="P:catecholamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002935">
        <property type="entry name" value="SAM_O-MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43836">
        <property type="entry name" value="CATECHOL O-METHYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43836:SF2">
        <property type="entry name" value="CATECHOL O-METHYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01596">
        <property type="entry name" value="Methyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51682">
        <property type="entry name" value="SAM_OMT_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0128">Catecholamine metabolism</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="337"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="381"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="9">
        <location>
            <begin position="507"/>
            <end position="700"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBF69540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="816" mass="91085" checksum="2E06FFF2ECE8FC55" modified="2005-04-26" version="1">MPEAVSQTVKRGAFDPSKAYAAQEGTTFFNDGREIELLHFVYSHPKLDSIRGSPESVLDAIDEYARTRKYLMNVGEDKGRIVCDLIAEVKPKTMVELGGYVGYSSILFGAAVRAAGGSRYYSLEMNPEFAAVIMALVDLAGLSDVVKVVIGPSDVSIARLYESAALTHIGLLFLDHYKPAYTTDLKLCEELKLITPGSVLAADNVIKPGNPPYLEYVRRSVDEKRKHLGVSTNGGGLPGKTVDQYKDKTGFGQMKLSQSRGNPNLIYESRLVESFEPTGVPQCGRAYENHGTPGAAGMPWPHSLTQHLILLLHKAEFRIPSSKMAEPFFYSHIPKNILLILLSLMFLPTTAIIAITSLVINYVSKTPEQGRFKESSAPKTILVTGVSMAKGLAIARLLARETPHRIIGADTEPLLFTSPGRYSQSIVKFYRLSSPRPGDPKPYLDSLLSVMRKEEVHLWISCSSVIGAVEDGEVMVMAEKEFGKDRFKAVQFDSETVKRFHEKDTFIDYIKSLELPVPESYRCTSVEEVTILLNQGREKAKRFIMKPIGVNDKARGKMMTLLPLDSEEATSSYLTALDISKSSPFLLQEYITGEEYCTHSLVVRGDVKAFVACPSSDMLMHYSATPPGSALSMKMLEFTTRVAERGGEDFTGHLSFDFLVQGRGEEARLSPIECNPRTHTAVILFQHTPEVAHAYLSVFGHNLDSKLKQDKGSSDIVAPATPDYNVYWIGHDLVTLLIIPVVTWIGGIRSTEETKHSLRTFWHHLLHWRDGTWALWDPVPFFALYHVYWPARFVECIFKNRKWSRINVSTTKMFEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AZL9</accession>
    <accession>C8V1I1</accession>
    <name>Q5AZL9_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_06261</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF69831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_663865.1">
        <property type="nucleotide sequence ID" value="XM_658773.1"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5AZL9"/>
    <dbReference type="GeneID" id="2871158"/>
    <dbReference type="KEGG" id="ani:ANIA_06261"/>
    <dbReference type="eggNOG" id="ENOG502QSDS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000374_2_0_1"/>
    <dbReference type="InParanoid" id="Q5AZL9"/>
    <dbReference type="OMA" id="DNRIDYM"/>
    <dbReference type="OrthoDB" id="2386201at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035361">
        <property type="term" value="C:Cul8-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019021">
        <property type="entry name" value="Mms22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28122">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SUBSTRATE RECEPTOR MMS22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28122:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SUBSTRATE RECEPTOR MMS22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09462">
        <property type="entry name" value="Mus7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="323"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="454"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="551"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="644"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="921"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="146"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="224"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="479"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="500"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="523"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="570"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="585"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="613"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="921"/>
            <end position="930"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF69831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="2322" mass="259813" checksum="FD386FAFA2A988DF" modified="2005-04-26" version="1">MESWRERGFVPDSDEEDGLDSQEMGLMLDATTKSANNVSVVVSALRSEEVAELAGDDHHNGSDGVNSQQRDNADTCGGNTGAGKEGHDGADIVEETVAPVDEDMDLPLLLPDRRLRTPDDDNGEAEPDLGISAAEEARSKERKKSVSSQSSNGSSTVGGSGSSTPRPKQQHDFWDIPSSSPDLLQRDYHPWRKQTSHAIAVTPTPKAKVPSQPHSQNENAQRALESSPLSSPLSSPRSSILGEMEEQQQQRREALDQTFEDLLPPLDIPEDILRQLDQPERRSLRQRNPIQLHPYLLEDAKYKSLMKARGLKPVRFPQQILQPARAADDESQEKDFGDDAGSTSDSQTTGLQYILSSPLDSRPLSEPRPIEDTVKRGDRRFDRQPKYSARSTGQRSPKRRRVVGPGDERQRQRYLSAPRPAPPQVVVDNVSSSEPDASSIFDIVSPLCSDSVSPSLMQKDTGAQFPRRFSPPVATPRTGTRESAHDNFEPVLLDDDENGLDQQSDIAGTIRSVTPSSSSGSDLNDEDEDEDAQEAIFRRFQKKIKGVLPASWLRLDQQKQKGGSGATQRNNDRMGRLDTEAAKGVARKITKKAHSSAPSSAREHILSLRQLAEEDNDQSSDISDDDDPQQNIARWVGFEDSSLDQKLWPDGDIPEDNQIDYMFPTAPRNPALSGSRKRAKKRRGQEGDEVRTGGQSKKPRLERQARLTDSVYRVQRKKRLSQKPPRLGILDAPDVASVPRNKQPQFLRIAARKARYREDRGRRSPSRKVIRLSSRMDTEDANASLREWRSGRVQQTTLPLVPSQTHRRQPLRGLSTNARQIFNGLSAKRAKESDRGETRQATLMRHGIAAKEISPTVNAPPNGVQHAAPTEYDNVTEENLLTVNAPLDITPSTRGTAMKPAQQRRGNAWIIQRNLAVTSLSRSSPRPVVPEFDSHDSTVRQPSSLQRSLALLARDDRLPLNRFLSTGERQQGHDILQSVPPTNIEIDKPVHAPKSAGALRPRQLRKRPPKRIDLTTNIQDFYSPNLKATEIPTGSTAQLSQGRGAGQLRHFRTAYSVDFDVNPLHTGIFFHESTFIGSGEFSRSLNITRRDLDKNTSSSHFQLGDCSMRWDAWDDSVSSQLGSVFDKILESAETAKAGGPGDISWNMPDSAYATYRAVIRYASEALSFIDPIDRAGFVTRANSLIAKLLEILSDIMAATGCSAEQFMKVASYNVVFANQVCQVASHSLVNQTIKHETINLAKTASRQVITLISSQAGQECLRKFLAASKQRKLQEEGIKDDHPIVEAYVIVRHVLCSADRFRGCLEDFVAEACPEVDAKSTEKDIGILESGWQQVLTTLPLQEIDVHGISRIGSRFQGGHDNWTVVKRLLRPVLESDEADLESRPISYYSYCRVLFQRCFILINGWGWRDCKPILDTLYDFFAKRTLYDLKSEESYKSPAFLDELDGNPSFQILPGDSCFHILLKILASGLRFLTKAYDKKTIRNYTWRLLPNHGRDYPKEQPIHQADLNALRNHHDLLCVLYSSVPDGCRPRLGTIKDLVHPATSHRETCKISLRTWTRLARFKLSTKEDISGLEPFAEWHGYFVTEFLKQHNLARKEIEAQIDGGNNFSQQLIDRTVAQNQRQIESLLKTALQGLQSAIKSAPSLEHAQKIVSQTPIKLILDLFDSRTTRLNATVLEGLQVIVMYLQKCGSLTGSSTTNSANTLISADEDSQDYGDWTDIEAVYGYESPPITSGVEHVEQVFHPAVSRLVSNCFGDDRCPDDAVLLGVVDCWSSMAHTLVKHKLRRWDSYLSPYEADSWLALRWTTQTRKFTPQFLAKCIEKDSEILSECKAQILGMWLSSLVERVSMLKFQHRFTEAILNWNTEDPVLRNLPFSQNPKEERYSITLSDLSQRRLSLISCVLSNMRVHVQNLDDVKSRDLSTTRQDYREVIQKMMSSMKSNYQELGNGEAEVKGAYVEFVQRIVGFLQQHTRDICPIDPFFTDTATFPLPSKDPLYIVARLRSYQPKLSSAKVAKTLVIFIQSVSERAALDAEQTYFVDQLCESMKNTYETGNLEQPTLRATLLQGVFPAYLATAFTNGAAWILSRPIIETITRVFQELLFSIDTTDSACVSSVMGIFCAIFESAYRALHHIITDANMLTQPEVLITTTAFLEMITSALPVVDYLDRLVADSSAMSHLLAQIRAFQNLSIFINACLQPRSQQSSEPHISLTPTLEVLHPSTSDLAVSATRELQTYINESWSRHQGKYYFTRRGAHAPQEVIIDASISAKLDSLPEKGVSDAATALLCALDSLDLFGESKDVGDHLQTNLSWEWKEEVLVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="102" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B017</accession>
    <accession>C8V2J1</accession>
    <name>Q5B017_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transaldolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_06113</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF70159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_658625.2"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047470_1_1_1"/>
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    <dbReference type="OMA" id="PIKPHDQ"/>
    <dbReference type="OrthoDB" id="1711136at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
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        <property type="evidence" value="ECO:0000318"/>
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        <property type="term" value="P:pentose-phosphate shunt, non-oxidative branch"/>
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        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001585">
        <property type="entry name" value="TAL/FSA"/>
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        <property type="entry name" value="TRANSALDOLASE"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="TRANSALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TAL_FSA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0704">Schiff base</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF70159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="391" mass="43226" checksum="391B69237A335D32" modified="2005-04-26" version="1">MGANAKAQSWLHKLEEQGMLCAFHEEGTGSLTNQTMPVNVDVDAMDPDFIKSLPITPHDMTSNQIHVHGQISEPKNRQLLLDVAREYKDRSWVDVYTRVAVLLCKKNINLISGRVLLQILPSYAYDRDKVLSHARLYAKEFESVEITKDRFCIKIPSTGPALSVCSTLEAEGIRTLGTAVFSLPQAIAASQAGCLYISPYFNEIRANFNLSLWPNVEDPATQHTMSARLMQMLEMYRKLYKETGKTQPLIKNANFISPKEALAQGEFGVDSATVSAEVLSQLANIPYDVSVRPSGIVDIPKPQYPEHQNSVSSTPKRLQHLATTDPLAAADWDGSIASTDVDYLKHNGAELEKAIKADPIASARISDALDVFLKVEGESRELIEGVMKELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="113" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B0R5</accession>
    <accession>C8UZZ2</accession>
    <name>Q5B0R5_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nucleolar GTP-binding protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ANIA_05865</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 7">Involved in the biogenesis of the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 7">Nucleus</location>
            <location evidence="2 7">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF70681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_663469.1">
        <property type="nucleotide sequence ID" value="XM_658377.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B0R5"/>
    <dbReference type="FunCoup" id="Q5B0R5">
        <property type="interactions" value="1211"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5B0R5"/>
    <dbReference type="GeneID" id="2871115"/>
    <dbReference type="KEGG" id="ani:ANIA_05865"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN5865"/>
    <dbReference type="eggNOG" id="KOG1490">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011784_4_1_1"/>
    <dbReference type="InParanoid" id="Q5B0R5"/>
    <dbReference type="OMA" id="EWKNDVM"/>
    <dbReference type="OrthoDB" id="415015at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902626">
        <property type="term" value="P:assembly of large subunit precursor of preribosome"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
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        <property type="project" value="GO_Central"/>
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        <property type="term" value="P:ribosomal subunit export from nucleus"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="P:rRNA processing"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="entry name" value="NOG"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Nucleolar GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024926">
        <property type="entry name" value="NOG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041623">
        <property type="entry name" value="NOG1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010674">
        <property type="entry name" value="NOG1_Rossman_fold_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012973">
        <property type="entry name" value="NOG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45759">
        <property type="entry name" value="NUCLEOLAR GTP-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06858">
        <property type="entry name" value="NOG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17835">
        <property type="entry name" value="NOG1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08155">
        <property type="entry name" value="NOGCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038919">
        <property type="entry name" value="NOG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="OBG-type G" evidence="9">
        <location>
            <begin position="168"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="542"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="546"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="566"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="605"/>
            <end position="615"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR038919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBF70681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="656" mass="74348" checksum="386A03793308D2AB" modified="2005-04-26" version="1">MKTTWKDIPPVPTSQEFLDIVLSRTQRQLPTQIRAGFKISRIRGFYTRKVKYTQETFGEKFQAILDGFPRLQDIHPFHKDLMNTLYDADHFRIALGQVSTAKHLIETVSRDYVRLIKYAQSLFQCKQLKRAALGRMATICRRLKDPLVYLEQVRQHLGRLPSIDPNTRTLLICGYPNVGKSSFLRSITRADVDVQPYAFTTKSLFVGHFDYKYLRFQAIDTPGILDHPLEEMNTIEMQSITAIAHLRSAVMYFMDLSEQCGYSVADQIKLFHSIRPLFANKIVFVVVNKIDVRRPEDLEPELQEQMQSMLKTGDVELLQLSCTTTEGVTNVKNAACDKLLAERVAQKLKSGTNSTGTPGGRLGDVLARIHVAQPMGGAQLETFIPDAVKNLKKYDKNDPNRKRLERDIEEENGGAGVYNVDLKKSYTLADDEWKHDKIPEVWNGKNIYDYVDPDIEAKLAALEEEEEKLEADGYYDSDESVEDAEDADVRMKADLIREKRTLMRNEAKLRKSLKNRAAIPRSAKAKKLSQMEQGLDAAGYDPEAAVSRVRSQSQVRGRTTTRSEVEDGDAMDIDPSDPRQAIARAKGRARSQAATNRLQDGVTDETARSKAERLAKLGQKKMNRMARQGEADRHQTVSLTKHLVAGKRGLGKTQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="136" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B0V3</accession>
    <accession>C8V075</accession>
    <name>Q5B0V3_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">ANIA_05827</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="16">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF70766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_663431.1">
        <property type="nucleotide sequence ID" value="XM_658339.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B0V3"/>
    <dbReference type="STRING" id="227321.Q5B0V3"/>
    <dbReference type="GeneID" id="2871194"/>
    <dbReference type="KEGG" id="ani:ANIA_05827"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN5827"/>
    <dbReference type="eggNOG" id="KOG0923">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001832_7_0_1"/>
    <dbReference type="InParanoid" id="Q5B0V3"/>
    <dbReference type="OMA" id="PLDPMMS"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071006">
        <property type="term" value="C:U2-type catalytic step 1 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000001">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000007">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000726">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF83">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR ATP-DEPENDENT RNA HELICASE DHX16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 15" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="491"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="680"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="108"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1108"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="450"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="136"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="166"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="179"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="216"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="231"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CBF70766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="1128" mass="128110" checksum="F7314E2F6DAB0AD6" modified="2005-04-26" version="1">MDNRTFVSDSLLRLANASDPTVVDFILATATSAKSSSSLQDKIAPFLDAGAEEVSSFCSELYKRVGKSETSAITNAGTGSGNRDGKTVAAGTEKKKYRLLDMDEVDYEGVSGTGSSLGPRSVETERKDRGRRAHDKSRDGDGNSKSHSDRWDKNENRKRERENSRDRRRSKKLRRRDVDDFEDRWGDEEILEEEEQDVEGEFAESPSKRARLEDGSASPRSRASSADLDPEERKERERKRDLEERDALAKRLASKDDKRSKKIVEDRTKDSEAARRRALADDAKARDAAMPDLRLRSRQEYLKKRETERLALLRRQVAEETQELRENPNLTRREKEEFARNREVLRIAEERLRIDDHRDGYMMPEDYITEKGKIDRKKKEDALYKRYVERDELGQEKFITEHEEWEMEQTAKAKAQINRAEFVDEGDYEYVFDDTQRINFTMDAQMKGTRKLMTQEQRMLQEKLDQAEQKAQTIEDTRKKLPIYQFRDQIIQAVHDHQVLIIVGETGSGKTTQLPQYLHEAGYTKNGMKVGCTQPRRVAAMSVAARVAEEMGVKLGNEVGYSIRFEDNTSDKTVLKYMTDGMLLRELLTEPDLGQYSALMIDEAHERTVPTDIACGLLKDIAKARPDLKLLISSATMDAQKFQSYFDNAPIFNIPGRMYNVDIHYTQQPEANYLAAAITTVFQIHVSQGPGDILVFLTGQEEIEAAEQSLQETARKLGNKIPEMIICPIYANLPSDLQAKIFEPTPPKARKVVLATNIAETSLTIDGIVYVIDPGFVKENVFNPRTGMESLVVTPCSRASANQRAGRAGRVGPGKCFRLYTKWAYYNELEESTTPEIQRTNLSSVILMLKSLGIDQLLEFDFMDPPPAETIIRALEQLYALGALNDRGELTKIGRQMAEFPTDPMLAKAILAADKHGCVEEVLSIVSMLGEASALFFRPKDKKIHADSARNRFTVKDGGDHLTLLNIWNQWVDSDFSYVWAKENFLQQRSLTRARDVRDQLAKLCDRVEVTVSSCGSNNIVPIQKAITAGFFPNAARLQRGGDSYRTIKTGQTVYLHPSSTLFEVNPRWVIYFELVLTSKEYMRSNMPLQAEWLVEVAPHYYKKKDLETLGTEKKPKGQGAVGGKSRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B1J0</accession>
    <accession>C8VG15</accession>
    <name>Q5B1J0_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Defect at low temperature protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">DLT1</name>
        <name evidence="9" type="ORF">ANIA_05590</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 7">Required for growth under high-pressure and low-temperature conditions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the DLT1 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF81605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_663194.1">
        <property type="nucleotide sequence ID" value="XM_658102.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B1J0"/>
    <dbReference type="GeneID" id="2871875"/>
    <dbReference type="KEGG" id="ani:ANIA_05590"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN5590"/>
    <dbReference type="HOGENOM" id="CLU_022833_2_0_1"/>
    <dbReference type="InParanoid" id="Q5B1J0"/>
    <dbReference type="OMA" id="SHYEYAR"/>
    <dbReference type="OrthoDB" id="4096362at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038869">
        <property type="entry name" value="DLT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40021">
        <property type="entry name" value="DEFECT AT LOW TEMPERATURE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40021:SF1">
        <property type="entry name" value="DEFECT AT LOW TEMPERATURE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="135"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="187"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="378"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="474"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="192"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="427"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="506"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBF81605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="553" mass="60339" checksum="1ADD1CE2E3A7D075" modified="2005-04-26" version="1">MLPSRPTALPNSNLATRIRNGTTITRLLNYTVFTLLSIILLCLILLTPADAIYQCYVTHRLTNIFIITGGYVVTFLLAVLIYATRIYTNRSVLGGIPKAWIPVEKEDVSKSVRRLVVEGLGRSALIARGARPRNLGRGSGANGPRDVDGNGQAFADPGAGDNEEKEGLLRGFDYDVDPSNPPWGVIEHPGWSAPESSLSASAPDQGTSDGDAQTPEPSLCYRTVIRELPHLIEAKAVSLAPPDPVFTVHPQYQTQTGEGDEATRIPDTRIVAILRRPGTMSLRSYINHLISLSILHPPEIGLEFLALYERARFSGKELYEDEFRELMGVFADVLRGMRFDQEHHRLLLDMNDYNEDGDLGHWRRNTSVFEHSLFGSKTESVIGPSDEEGETTETDTLGSVNINIDSPRRRHRRQRQSRSGPRSRPVHGNDHTYNHTDGHPNLEPASRPPPGQSRSRSQSLVDFKAGNLSENAIYWPRAGARTPSTHSARSLHPDRSYGSGSGADAGSGLSLRSASRSGSASGSASVSLSGGSVIRLADARTESVSGLPYVIGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="111" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B240</accession>
    <accession>C8VGN3</accession>
    <name>Q5B240_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Zn(II)2Cys6 transcription factor (Eurofung)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ANIA_05390</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF81987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_662994.1">
        <property type="nucleotide sequence ID" value="XM_657902.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B240"/>
    <dbReference type="STRING" id="227321.Q5B240"/>
    <dbReference type="GeneID" id="2871681"/>
    <dbReference type="KEGG" id="ani:ANIA_05390"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN5390"/>
    <dbReference type="eggNOG" id="ENOG502SI37">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013869_2_0_1"/>
    <dbReference type="InParanoid" id="Q5B240"/>
    <dbReference type="OMA" id="ECPGYVQ"/>
    <dbReference type="OrthoDB" id="5418899at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
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        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
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        <property type="term" value="F:zinc ion binding"/>
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        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
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    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Fun_TF"/>
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    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF18">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="9"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="57"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="513"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="64"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="136"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="189"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="519"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBF81987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="706" mass="78177" checksum="9E21C98377296426" modified="2005-04-26" version="1">MPGVPSNKACERCKKRHLKCDETRPHCQRCADAGVECPGFVQTRKFIDQGASVRRRYAPYQEAGSKNTTAKPSRVANNPQPESLHNEATSTGLEPQGQSNPPVPPAPLVYDREHRPAIRSETSVLDSAPLAEASQPPATTMSVNRTGGDAVLGPMRWQGSDARAQQPSWALGNAGAGAGTGTFHERSRQSSPHVNPSSSRTPSQRGEQEEFQDIFSELMTGTEHEICFLTRHYCEVIAAWFDVSDSGKFFGGCVPIRAIDDQSLRCAIASISAKHLARMKGVKSTAGGGLFTSPATMESYPNSPHVDWSLKAANYYYLAVSHMSNSLSDYAAVSTSDVLEPPISVVNRWLNFQLKQSEQTSHTSDVAWKTAENLLAASTILTLYKIFDEPGENWQSYLTGVKPLFSKLLELLKKDGGNQFFPGLTAVFWNFARMDYLASYYNRLPTHLDPDDLALWRAAGLSLDDQGNLESSEVSRSHWSQEDVATNVLTRLLNKLTNYLAAAKKSQLEQWVGGQSPQSINSTRSSSDSPDSHPTTASWLKISFEFQSWVERIPETFRPCLRIERPKLAPTEPSHMPFPEIFYSLTSCAVAMQQYHFGRLALSLNRPSDDIAGPSTAFDRLQAYRELTKEVDYRCKEICGIALGRPQIGARVQMITLLYAVGQCLEKPEDRQIVIDLLRGIEADLGWSTATQLEYCSTSGYFYGFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="119" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B2D2</accession>
    <accession>C8VGY2</accession>
    <name>Q5B2D2_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Mitochondrial thiamine pyrophosphate carrier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">ANIA_05298</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF82147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_662902.1">
        <property type="nucleotide sequence ID" value="XM_657810.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B2D2"/>
    <dbReference type="STRING" id="227321.Q5B2D2"/>
    <dbReference type="GeneID" id="2871588"/>
    <dbReference type="KEGG" id="ani:ANIA_05298"/>
    <dbReference type="eggNOG" id="KOG0756">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1441043_0_0_1"/>
    <dbReference type="InParanoid" id="Q5B2D2"/>
    <dbReference type="OMA" id="YNETLDC"/>
    <dbReference type="OrthoDB" id="44467at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071913">
        <property type="term" value="F:citrate secondary active transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006843">
        <property type="term" value="P:mitochondrial citrate transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049563">
        <property type="entry name" value="TXTP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788">
        <property type="entry name" value="SUCCINATE/FUMARATE MITOCHONDRIAL TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788:SF4">
        <property type="entry name" value="TRICARBOXYLATE TRANSPORT PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="136"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CBF82147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="188" mass="20150" checksum="461DDC6AF9DC602A" modified="2005-04-26" version="1">MKNSSPSLWQSILAGEAAGGFESPLTLSPRLNTGARGILRLQRKQIRSPVLRIRDSTPIDAHGHFRKVHRTGNMGAGIIAGAAESILVVTPGETLKTKIIDNEAGAKRYTSARALSGRRLPPRESPAMSGSDSNNSVIGATVVAGALAGVVTVYATMPFDTLKTRLQALDARQRYNETLDCLKTIRFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B2J4</accession>
    <accession>C8VFB4</accession>
    <name>Q5B2J4_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DUF914 domain membrane protein (AFU_orthologue AFUA_5G07810)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ANIA_05236</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC35F solute transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF81140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_662840.1">
        <property type="nucleotide sequence ID" value="XM_657748.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B2J4"/>
    <dbReference type="GeneID" id="2871523"/>
    <dbReference type="KEGG" id="ani:ANIA_05236"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN5236"/>
    <dbReference type="eggNOG" id="KOG2766">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039639_4_1_1"/>
    <dbReference type="InParanoid" id="Q5B2J4"/>
    <dbReference type="OMA" id="VRYHWAQ"/>
    <dbReference type="OrthoDB" id="429955at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009262">
        <property type="entry name" value="SLC35_F1/F2/F6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052221">
        <property type="entry name" value="SLC35F_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14233">
        <property type="entry name" value="DUF914-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14233:SF4">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER F2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06027">
        <property type="entry name" value="SLC35F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="60"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="160"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="287"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="312"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="338"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBF81140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="399" mass="44663" checksum="EFF90F5A5F07C5F4" modified="2005-04-26" version="1">MSDTKHRPAVQTTAAEHYGEVPSPVVSAHPTRESSAPEIAADLVDEQKKGFFAYFRTKEFYVTLLLGQFLAIANTGTNTFNTLLANKNTNIPAFQTFFNYSLLNIIFTSYTIYKYGIKGWFEMLWKRGWKYIILSFCDVEGNYFMVLAYEYTTMMSAQLINFWAIVVVVVVSFLFLRVRYHISQVLGILICIGGMGILIASDHIQGTNGGDISRGNQIKGDLFALLGASFYGLANTGEEFFVSTAPVYEVIGQMGFFGMIINGVQAAIFDRKSIQHAHWDGQVGGYLTGYTLCLSIFYSTAPLLFRLASAAFFNISLLTMNFWGVIIGIRVFHYSVHWMYPIAFVLIIVGQLVYYLGRKVLGEARKPWLGRNQERGVAGIFTAKRRIESSAAAFRTAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="121" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B302</accession>
    <accession>C8V801</accession>
    <name>Q5B302_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BHLH transcription factor (Eurofung)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ANIA_05078</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF76137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_662682.1">
        <property type="nucleotide sequence ID" value="XM_657590.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B302"/>
    <dbReference type="STRING" id="227321.Q5B302"/>
    <dbReference type="GeneID" id="2872875"/>
    <dbReference type="KEGG" id="ani:ANIA_05078"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN5078"/>
    <dbReference type="HOGENOM" id="CLU_915354_0_0_1"/>
    <dbReference type="InParanoid" id="Q5B302"/>
    <dbReference type="OMA" id="NGGMEFI"/>
    <dbReference type="OrthoDB" id="4511011at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051732">
        <property type="entry name" value="USF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46117">
        <property type="entry name" value="FI24210P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46117:SF3">
        <property type="entry name" value="FI24210P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="7">
        <location>
            <begin position="142"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="29"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="188"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="266"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="221"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="67"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="82"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="188"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="206"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBF76137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="304" mass="33180" checksum="63C1DACCBE1EB760" modified="2005-04-26" version="1">MLALAPQISIGGTEFMNLGPLSQNLTPQTLAGGGGITPEEGLPINFNISPFVESPQPTDDAESGNSPLQQQQQQQQQQHQSPPVPPQIPPHMPPQISFHPQIRPPYGISIPTIHRVKLDRIRRNSAPELSLHELERQTKHANRRASHNIVEKRYRINLNSKFRKLHEIVFCRTDPTFVPDIANANGSSNSANSNSEGPASAPVSAIATQANRSQPPKASIIDSALNYIESLQREVHELKRRLEVYEKDGAPLQGLGRVGGKALPDLGAEIGSGDAQDYANDEHTKEGCESSSVKSESPFAWTIT</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-04-04" modified="2026-01-28" version="114" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B3H7</accession>
    <accession>C8V9G6</accession>
    <name>DBP8_EMENI</name>
    <protein>
        <recommendedName>
            <fullName>ATP-dependent RNA helicase dbp8</fullName>
            <ecNumber>3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">dbp8</name>
        <name type="ORF">AN4903</name>
    </gene>
    <organism>
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">ATP-binding RNA helicase involved in 40S ribosomal subunit biogenesis and is required for the normal formation of 18S rRNAs through pre-rRNA processing at A0, A1 and A2 sites. Required for vegetative growth.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text>The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DEAD box helicase family. DDX49/DBP8 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13"/>
    <dbReference type="EMBL" id="AACD01000084">
        <property type="protein sequence ID" value="EAA60981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF76513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_662507.1">
        <property type="nucleotide sequence ID" value="XM_657415.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B3H7"/>
    <dbReference type="SMR" id="Q5B3H7"/>
    <dbReference type="FunCoup" id="Q5B3H7">
        <property type="interactions" value="803"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5B3H7"/>
    <dbReference type="EnsemblFungi" id="CBF76513">
        <property type="protein sequence ID" value="CBF76513"/>
        <property type="gene ID" value="ANIA_04903"/>
    </dbReference>
    <dbReference type="GeneID" id="2872706"/>
    <dbReference type="KEGG" id="ani:ANIA_04903"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN4903"/>
    <dbReference type="eggNOG" id="KOG0340">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_1_1_1"/>
    <dbReference type="InParanoid" id="Q5B3H7"/>
    <dbReference type="OMA" id="IMIFTDT"/>
    <dbReference type="OrthoDB" id="10261904at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd17955">
        <property type="entry name" value="DEADc_DDX49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF24">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0347">Helicase</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0690">Ribosome biogenesis</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0698">rRNA processing</keyword>
    <feature type="chain" id="PRO_0000232287" description="ATP-dependent RNA helicase dbp8">
        <location>
            <begin position="1"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="126"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="3">
        <location>
            <begin position="337"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif">
        <location>
            <begin position="95"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DEAD box">
        <location>
            <begin position="248"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="139"/>
            <end position="146"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <sequence length="525" mass="56975" checksum="67AD1473326C4B5E" modified="2005-04-26" version="1">MAPLSTPESISREISVSSDASADESTSLDQMRAPKRRRLSESSTDSYTAAPAPLPSLSRIKKKSSSTNATSSRKDDENPVLIKDALEIGLNAEENSFKALNVAPWLVGSLTTMAVRKPTAIQRACIPEILKGRDCIGGSRTGSGKTIAFSVPILQKWAEDPFGIFAVILTPTRELALQIFEQIKAISAPQSMKPVLITGGTDMRSQAIELAGRPHVVVATPGRLADHINTSGTDTVAGLKRVRMVVLDEADRLLSPGPGSMLPDVETCLSFLPGPSQRQTLLFTATLTPEVRALKSMPQTPGKPPIFVTEISTEAKDTVPPTLRTTYVQVPLTHREAFLHVLLSTESNITKSAIVFTNTTKSADLLERLLRSLGHRVTSLHSLLPQSERNSNLARFRASAARVLVATDVASRGLDIPSVSLVVNFEVPRNPDDYVHRVGRTARAGRTGEAVTLVGQRDVQLVLAIEERIGRKMVEYEEEGVNLEARVAKGSLLKEVGAAKREAMVEIDEGRDVLGRKRNKLKKVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="111" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B3Q1</accession>
    <accession>C8VA94</accession>
    <name>Q5B3Q1_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">D-xylose reductase [NAD(P)H]</fullName>
            <ecNumber evidence="3">1.1.1.307</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">ANIA_04829</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the initial reaction in the xylose utilization pathway by reducing D-xylose into xylitol. Xylose is a major component of hemicelluloses such as xylan. Most fungi utilize D-xylose via three enzymatic reactions, xylose reductase (XR), xylitol dehydrogenase (XDH), and xylulokinase, to form xylulose 5-phosphate, which enters pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>xylitol + NAD(+) = D-xylose + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27441"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17151"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.307"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>xylitol + NADP(+) = D-xylose + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27445"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17151"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.307"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate metabolism; D-xylose degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.307" evidence="3"/>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF76682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_662433.1">
        <property type="nucleotide sequence ID" value="XM_657341.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B3Q1"/>
    <dbReference type="STRING" id="227321.Q5B3Q1"/>
    <dbReference type="GeneID" id="2872631"/>
    <dbReference type="KEGG" id="ani:ANIA_04829"/>
    <dbReference type="eggNOG" id="KOG1577">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_0_0_1"/>
    <dbReference type="InParanoid" id="Q5B3Q1"/>
    <dbReference type="OMA" id="RHQRMNF"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004032">
        <property type="term" value="F:aldose reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042732">
        <property type="term" value="P:D-xylose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19071">
        <property type="entry name" value="AKR_AKR1-5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000007">
        <property type="entry name" value="NAD(P)H-dependent D-xylose reductase xyl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0859">Xylose metabolism</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="13">
        <location>
            <begin position="18"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="12">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CBF76682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="326" mass="36570" checksum="DA0EC7EC1C41A246" modified="2005-04-26" version="1">MALKRTFKLNTGYEIPAVGLGTWQSKPSEVEEAVTAALNIGYRHIDAAAVYGNERDVGNGIKASGVPRGEIFLTSKLWNTHHDPENVEAAVDRSLSDLQTDYLDLYLIHWPVAFRYSTTTIQPVDEKTGLIDVIDVPIKDTWAAMEALVAKGKVRSIGVSNFNRRRIEELLKTAKIPPAVNQIEAHPYLQQRELLEWSKEKGILITGYSPLGNNIYNIPRTVDDPLVIEVAKFLNRTPAQVLISWAVQRGTAVLPKSVTPERIKSNFRDFILPEDAFQAIQSLERHQRMNFPARLGVDIFDEVGEESARRSALEWAEGQRLSKSQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="102" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B3Q7</accession>
    <accession>C8VAA1</accession>
    <name>Q5B3Q7_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Polysaccharide deacetylase, putative (AFU_orthologue AFUA_3G07210)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ANIA_04823</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF76696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_662427.1">
        <property type="nucleotide sequence ID" value="XM_657335.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B3Q7"/>
    <dbReference type="STRING" id="227321.Q5B3Q7"/>
    <dbReference type="GeneID" id="2872622"/>
    <dbReference type="KEGG" id="ani:ANIA_04823"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN4823"/>
    <dbReference type="eggNOG" id="ENOG502S8H7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022194_1_0_1"/>
    <dbReference type="InParanoid" id="Q5B3Q7"/>
    <dbReference type="OMA" id="RIMRVDQ"/>
    <dbReference type="OrthoDB" id="2128708at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004099">
        <property type="term" value="F:chitin deacetylase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10917">
        <property type="entry name" value="CE4_NodB_like_6s_7s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46471">
        <property type="entry name" value="CHITIN DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46471:SF6">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0170">Cobalt</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030175764" evidence="8">
        <location>
            <begin position="23"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="9">
        <location>
            <begin position="228"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="438"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBF76696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="458" mass="52394" checksum="3F292EAA39E61F52" modified="2005-04-26" version="1">MRPMVSLSQAFLALSPFLFTSAVQLLPPPPIPINSTSAFIRTPASSALHSKNRPPVLVIDSFTHPERNELGFWHGPSTNLASEPGNGYVRLFPSDPDQNYHTELGPATCFDMRPYQNMYLHIVFSGSTKFSISLNQHNEKCDSRLSPFLETWDSVETERYARGNDVYVPLNHFDIDQSRTVSVSFHGFFSPETVTLYRVEIVPDLPWGFYVPPKLETGKLFLRCTRPNSFAFGIDDGLPHLVQDVMNILEEEKILVTFFVVGAGLRDKEANFSQVYEEMLRRGHQVALHSDTHQQIEALDTIQAIDEEIVHNIETFQRLLGIHSRYFRPPYGTVGARTRQRLATYVQDPNIINWSVDVEDWLWAESKTPERQRDAFFRDVGRGGNLVVMHYLSPTTVKYFREFIRFVKSINLNIMRVDQCLEDPDSPPIDALRLSQQGRARYRVQSNRKSDNNPGKTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B4B7</accession>
    <accession>C8V7S5</accession>
    <name>Q5B4B7_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">37S ribosomal protein Rsm22 (AFU_orthologue AFUA_2G02290)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ANIA_04613</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Mitochondrial ribosome (mitoribosome) assembly factor. Binds at the interface of the head and body domains of the mitochondrial small ribosomal subunit (mt-SSU), occluding the mRNA channel and preventing compaction of the head domain towards the body. Probable inactive methyltransferase: retains the characteristic folding and ability to bind S-adenosyl-L-methionine, but it probably lost its methyltransferase activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF77146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_662217.1">
        <property type="nucleotide sequence ID" value="XM_657125.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B4B7"/>
    <dbReference type="FunCoup" id="Q5B4B7">
        <property type="interactions" value="286"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5B4B7"/>
    <dbReference type="GeneID" id="2872413"/>
    <dbReference type="KEGG" id="ani:ANIA_04613"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN4613"/>
    <dbReference type="eggNOG" id="KOG2539">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007075_1_0_1"/>
    <dbReference type="InParanoid" id="Q5B4B7"/>
    <dbReference type="OMA" id="CTNHSTC"/>
    <dbReference type="OrthoDB" id="421327at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052571">
        <property type="entry name" value="Mt_RNA_Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015324">
        <property type="entry name" value="Ribosomal_Rsm22-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13184">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN S22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13184:SF5">
        <property type="entry name" value="METHYLTRANSFERASE-LIKE PROTEIN 17, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09243">
        <property type="entry name" value="Rsm22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="771"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="828"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="771"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="828"/>
            <end position="841"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00045681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBF77146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="855" mass="96067" checksum="0543F8321517D24C" modified="2005-04-26" version="1">MLSRSPALRATRAKPKNIIIPGYGSLHAGSRRLRCRAPTLTNPQFSTKSTANAADSLKSIRHSGRTPNTYKSGHFVTGQRYFSSAKEADSKTEPDDALYALIDKINTTEAEILELLDELDLTDEYSGSGSSTQEVLDEASNKAAYHVEEQTAEERVHQARQAFGDTLPDGYLNEEETLLYSRLYGEPINLPEHESEVEGKQDEADRLFRDDGVGGWEEVPYDATETQNDWPVVYDMEAPPIEETAAMQRTREVAEQLGAEIMLETLEEQEAEGSSPRLHPLTRQGKFATDPYTVFPPKDTVTGPISAILSEFSNKHIAEAAHKAFGGKLLPQSTRTAPAHAQEPQEAIGLSASQRFMSEMEANAYMAVLYPGMYASTLSVLTEVRKRLGSDWLRSLISQEGGPNVLDAGAGGAAILAWRDVLRAEYELMVPDHPTSDPYPLGRSTVLTGSDPLRLRASLMLENTTFLPRLPDYIHTRDSPTVHDSRPPKRKQFDLVIAPYALMNFSEEYERKEYVENLWQLLKPNGGVLVLMEKGHQKGFEAIAGAREMLLKRYISSPGSTEYDALTESAGDDRKVQKEPGMIVAPCTNHERCPMYHTDGHAKGRKDYCHFEQRYIRPTFHQRIIGAKDRNHEDLKFSYVVVQRGVDLRQTEHIVQGSQATDAAFEGYEHLNEAGEVAEAEEVARTEVETPEPLSPAPETKFHALSLPRVLYPPMKRRGHVIFDMCTPAGKIERWTVPRSFSRRAFKDARKARWGDLWALGAKTRIPRNLKLGDKRGEGKKERLARRAAERSDFQEGEGNLDDLDEYVEGRPSHSHLDIANLMREKGEKKIPSWKKHAENKRLRHASRKIARESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="107" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B4J5</accession>
    <accession>C8V892</accession>
    <name>Q5B4J5_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">F-box domain protein (AFU_orthologue AFUA_2G02860)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_04535</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF77304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_662139.1">
        <property type="nucleotide sequence ID" value="XM_657047.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B4J5"/>
    <dbReference type="STRING" id="227321.Q5B4J5"/>
    <dbReference type="GeneID" id="2872333"/>
    <dbReference type="KEGG" id="ani:ANIA_04535"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN4535"/>
    <dbReference type="eggNOG" id="KOG4341">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025082_0_0_1"/>
    <dbReference type="InParanoid" id="Q5B4J5"/>
    <dbReference type="OMA" id="SRLDRKW"/>
    <dbReference type="OrthoDB" id="550575at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000675">
        <property type="entry name" value="F-box domain protein (AFU_orthologue AFUA_2G02860)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001680">
        <property type="entry name" value="F-box domain protein (AFU_orthologue AFUA_2G02860)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057207">
        <property type="entry name" value="FBXL15_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25372">
        <property type="entry name" value="DUF7885"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="166"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="598"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF77304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="723" mass="80385" checksum="86D87CA89B7A6E30" modified="2005-04-26" version="1">MATVDPEIVPFPEAPTSASPSSSADQIPLQQAQKVKGRHRLLQGLQRFSSSPSLTRRNRSRSASTTYRQNGASLSCVSLSQSAYAPCSSNGSATQLYGGLNIRPTTPGPTGSHAADDQEGNARIRFVADTINGPQPKKIALPTEMRPGSRGAVLEDTALIAKPKQFDFWGKMPNELGMLIFSYLTPKEIIRCSTVCKWWHRMCYDGQLWTVIDTTDYYSDISCDALMKLIMSGGPFIKDLNLRGCVQLRERWENEIDEITAVCRNVVNFSLEGSRMDKYPVHSFIGRNQRLQYVNLAGLDSVTNATMKIIAKSCHQLRTLNVSWCTNVTATGLKRVVKACPILADLLASEILGFDEVELSSELFKRNTLERLDISRTDITDESLKVLMHGIDPEIDILEERAIVPPRRLKHLDLHQCSELTDDGVKTLAHNVPHLVGLQLSGCPELTDNSIVPVIQTVPHLTHLELEELEHLSNRTLLELAKSPCAPFIEHINISSCESLSDPGMLQVMKSCPSLRFVEMDNTRISDLTLSEASYRVRKRGYDETLPQIGLRIVAFDCPNVTWVGVRDILAGNAYIPRQYKVPVPEAVSVINQALNSSKTSGSASEPLKPMISSSITPPPPPTVYPNHIIQLKCFYGWQATVEEHTKRVLRGDLAAANRLEKKWFDYMVATEEAGLGGAGARRRRRRAREAERIYNEDDEEEPYFGLLGGRRRARSGGSCVVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B4M4</accession>
    <accession>C8V8C7</accession>
    <name>Q5B4M4_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ANIA_04506</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
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            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CBF77371.1"/>
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        <property type="nucleotide sequence ID" value="XM_657018.1"/>
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    <dbReference type="eggNOG" id="ENOG502T6H4">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="InParanoid" id="Q5B4M4"/>
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        <property type="component" value="Chromosome III"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF77371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="308" mass="34948" checksum="F46FFD40A6B5F076" modified="2005-04-26" version="1">MCTNSYFQTDKEALEGIVDSFEAAGELLLVAVEGAIIEPFGIEFARCCGEAPAPQTYTRTLTKALQHSDDPKCLCHPRPKKPFPKLELVIRGSKPEESRRLDQVGAQLDVVFDLIGNGLTLRETIGDPTVAKASYSIAFLLKSKMIDFVNLQGLSDDSLLLSFRMQPSFCTATGKGRMTYKEKYQGFSPNRLESRLYNDFYSCNWFEQHLELLLPAERIMGWKTVALVLKTFQRITPENWCHMVKLRNRPGVAGLNWMAIEDKVMPRKIQAPVVLFPSEEEKKMHYLIEKKKAAAKRAMQKQGLLCNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B4W2</accession>
    <accession>C8V8S3</accession>
    <name>Q5B4W2_EMENI</name>
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        <submittedName>
            <fullName evidence="3">C2H2 finger domain protein, putative (AFU_orthologue AFUA_4G07090)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_04418</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF77567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_662022.1">
        <property type="nucleotide sequence ID" value="XM_656930.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B4W2"/>
    <dbReference type="GeneID" id="2872215"/>
    <dbReference type="KEGG" id="ani:ANIA_04418"/>
    <dbReference type="eggNOG" id="ENOG502RYIG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015534_1_0_1"/>
    <dbReference type="InParanoid" id="Q5B4W2"/>
    <dbReference type="OMA" id="SGHPFTN"/>
    <dbReference type="OrthoDB" id="3524154at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057026">
        <property type="entry name" value="Znf-C2H2_ascomycetes"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24537">
        <property type="entry name" value="zf-C2H2_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type zinc finger ascomycetes" evidence="2">
        <location>
            <begin position="453"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="370"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="426"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="145"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="188"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="214"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="226"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="321"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="370"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF77567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="132" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B564</accession>
    <accession>C8V978</accession>
    <name>Q5B564_EMENI</name>
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        <submittedName>
            <fullName evidence="11">MFS myo-inositol transporter, putative (AFU_orthologue AFUA_4G06080)</fullName>
        </submittedName>
    </protein>
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        <name evidence="11" type="ORF">ANIA_04316</name>
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    <organism evidence="11 12">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF77781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_661920.1">
        <property type="nucleotide sequence ID" value="XM_656828.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B564"/>
    <dbReference type="GeneID" id="2872116"/>
    <dbReference type="KEGG" id="ani:ANIA_04316"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN4316"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_5_1"/>
    <dbReference type="InParanoid" id="Q5B564"/>
    <dbReference type="OMA" id="ETGWRWM"/>
    <dbReference type="OrthoDB" id="6339427at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005366">
        <property type="term" value="F:myo-inositol:proton symporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904679">
        <property type="term" value="P:myo-inositol import across plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000073">
        <property type="entry name" value="MFS myo-inositol transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050814">
        <property type="entry name" value="Myo-inositol_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020:SF12">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="38"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="197"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="301"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="326"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="353"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="395"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="432"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="460"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="42"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CBF77781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="517" mass="56316" checksum="F7ADD2D433958C94" modified="2005-04-26" version="1">MNSREDTELSAAHAPLLAQEPVLRQHDEDQSKHSSGRFIWYLTFSAGISGLLFGYDTGVISSTLVSIDSDLSNRPLTTLDKSLITSCTSLFALIASPLAGILADRLGRKRVILVADVLFTVGSFIQAATGEVWGMIIGRSIVGFAVGSASLVTPLYISELAPSDARGRLVTILSLFITGGQVVAYIIGWLFSYVGGGWRWMVGLGMLPAVFQLIIVVALPKTPRWLVQAGYEDKAQRILSEVHQDDQTAKQTLRDIQQEVAEENSSNKSAGFKQRSHDLFKIAGNRRALTIAVMLQALQQLCGFNSLMYFSATIFSLLSFSSPTLTSLSVALTNFLFTLLAFVYIDRIGRRRILLYSIPVMIISLFVCAVTFSFVELPKDTSEAQARQAATDSSVIPLLILLCLTVYTAAYAFGLGNVPWQQSELFPLNVRSLGSALATATNWGSNFVVGLTFLPMMELLSPSLVFALYGVVCIAGWFGVRTFYPEMSGLNLEDVKALLADSWGVRASLIGVRNRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="105" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B587</accession>
    <accession>C8V9A1</accession>
    <name>Q5B587_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Nuclear pore complex protein An-Nup133 (Eurofung)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ANIA_04293</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus envelope</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleoporin Nup133 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF77824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_661897.1">
        <property type="nucleotide sequence ID" value="XM_656805.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q5B587">
        <property type="interactions" value="123"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5B587"/>
    <dbReference type="GeneID" id="2872094"/>
    <dbReference type="KEGG" id="ani:ANIA_04293"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN4293"/>
    <dbReference type="eggNOG" id="KOG4121">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002493_0_0_1"/>
    <dbReference type="InParanoid" id="Q5B587"/>
    <dbReference type="OMA" id="HVATLLW"/>
    <dbReference type="OrthoDB" id="103454at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000972">
        <property type="term" value="P:transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001057">
        <property type="entry name" value="Nuclear pore complex subunit Nup133, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007187">
        <property type="entry name" value="Nucleoporin_Nup133/Nup155_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014908">
        <property type="entry name" value="Nucleoporin_Nup133/Nup155_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037624">
        <property type="entry name" value="Nup133-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13405">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13405:SF11">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03177">
        <property type="entry name" value="Nucleoporin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08801">
        <property type="entry name" value="Nucleoporin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117289">
        <property type="entry name" value="Nucleoporin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup133/Nup155-like N-terminal" evidence="10">
        <location>
            <begin position="153"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin Nup133/Nup155-like C-terminal" evidence="9">
        <location>
            <begin position="618"/>
            <end position="1254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1263"/>
            <end position="1293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="57"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1267"/>
            <end position="1284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CBF77824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="1293" mass="144274" checksum="38B4EBAE90995DF5" modified="2005-04-26" version="1">MFVPKAGSATTLRNPRRRQRTSSGESIKAPSAKRQRSILSQDDNPDTGIPTYGAPNHRSSIPTATTEVDSTPAPGGENQKNIPIRTFNATEKRKSDVLGPIILYLNCHVYLTKSETSVQKIADVLSPPAMGMGLLSLNSRPSFGRIPPWSHRPYLPMDASDVSPLGVILSTATSSTPGLMILMPHNGRIIYWETVSCAASLSLPRQKQTGLQGYVPGMLSGECATDIVNAEPSGVIVTFSTGRVAHITLRDSQGKPAVTVNFLKNPHSTGGIGFLDGIKNVFGAGYWRKKVAAVRAGESFQRGQRDIIIATSAGLVEVWDTHWNNGSILKNQYDVKEDLLAATRKDEASDYEVKIWDLAVVTSSCEDSSNPWEISVLVGLFSGVTIQGVFVTRLRLTDGARVLSTNPISLHTFPTDSLHLEPRLFIPKPHETAFIVIGQSIILLSLTDAEGTSSSQLLIDNGQPRTFHDSINFRSGQAYEILGSGFEDQSEEYANPSCLLMIREFGVVRITALPRQETAETARISAQHKLEQAVFYGTMLGNPLNLSSKGDLDFPVPEIEQATLAICQGLLRSTSKFIPSAAISIDQNLKLRSKALDDLSRILLDQNKIIDRRIWWELLWGAEKLAAQRAIWRLEASARKRNSSGATFLAHVLGLMNEKFKTKLDDTDDPIRQWFLFDSYRMEHIVPWIFHAIKPQKGNTSKQMRRMSEQILEAGELSLAVLETAFRYRDEHASQFGIGDGYLEEGVLTTNYEGLPEFWTSQSISYSEIGHLLDLELDSCRAIQQTSTSSDGGDQQISAKIARNSARHLRIMGQMYSERIRWLSAQEDQKLIDEASATKQSHIKQRRWQLFKLAGIGQLNEAIELAESFQDMSALVELIIELQDQNKVVFTNVDTPDGIELDRKISLYFEKFGDAWADAFFGRQISMGQPGILFSAKKFQSFVTRFLHKHQPYARLSWINDVIGEADYECAAKTLEHLALEQEQDVWGHRVKLALAKLSHLARWEKDAPSDTRALQNDIKRLEGLAEMGAVQEVIYSYVSPVLRDAIDQKAEIDLAIDHFAKSTAQKLPSLHELLKEALTGVVTRKMLSLDQLVDVLTLIDPSQDPDIGQNDFSGDEFHLALRVIRLGHNAQGDPNYSLALQKLVWRRCIIRDKWDATGGTAEQMGSETESPLTATALSRTLALCLNDRTDPSKPPLYRPTRPQDVLLNDSDSALISSRFRPEQRARIIRDLERENSTLLRYIEKSELECWFKSLLSSAEKERTSDDALQTPCSMDAESSLSQTNRKERLSWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="132" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B5W6</accession>
    <accession>C8V5H4</accession>
    <name>Q5B5W6_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">ADP/ATP translocase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">ADP,ATP carrier protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">ANIA_04064</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="18">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell. Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane.</text>
    </comment>
    <comment type="function">
        <text evidence="16">Catalyzes the exchange of ADP and ATP across the membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ADP(in) + ATP(out) = ADP(out) + ATP(in)</text>
            <dbReference type="Rhea" id="RHEA:34999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:35000"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="3 16">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Membrane</location>
            <topology evidence="16">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF74779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_661668.1">
        <property type="nucleotide sequence ID" value="XM_656576.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B5W6"/>
    <dbReference type="FunCoup" id="Q5B5W6">
        <property type="interactions" value="941"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5B5W6"/>
    <dbReference type="GeneID" id="2873480"/>
    <dbReference type="KEGG" id="ani:ANIA_04064"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN4064"/>
    <dbReference type="eggNOG" id="KOG0749">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_12_0_1"/>
    <dbReference type="InParanoid" id="Q5B5W6"/>
    <dbReference type="OMA" id="CWATIYK"/>
    <dbReference type="OrthoDB" id="270584at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005471">
        <property type="term" value="F:ATP:ADP antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140021">
        <property type="term" value="P:mitochondrial ADP transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990544">
        <property type="term" value="P:mitochondrial ATP transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000001">
        <property type="entry name" value="ADP,ATP carrier protein, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002113">
        <property type="entry name" value="ADT_euk_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45635">
        <property type="entry name" value="ADP,ATP CARRIER PROTEIN 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45635:SF14">
        <property type="entry name" value="ADP_ATP TRANSLOCASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00927">
        <property type="entry name" value="ADPTRNSLCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0050">Antiport</keyword>
    <keyword evidence="11 14 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 14 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 15" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="13"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="118"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="218"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
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    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU368008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CBF74779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="311" mass="33812" checksum="85CA3BF479EAF17C" modified="2005-04-26" version="1">MASQSDKSVLGMPGFVVDFLMGGVSAAVSKTAAAPIERVKLLIQTQDEMLRSGRLDRKYNGLMDCFRRTTQAEGVVSLWRGNTANVIRYFPTQALNFAFRDTYKSMFAYKKDRDGYAKWMAGNLASGGMAGATSLLFVYSLDYARTRLANDAKSTKGGGERQFNGLIDVYKKTLASDGIVGLYRGFGPSVLGIVVYRGLYFGMYDSLKPVVLTGALEGSFLVSFLLGWGVTTGAGIASYPLDTVRRRMMMTSGEAVKYSSSFDAFRQIIAREGVKSLFKGAGANILRGVAGAGVLSIYDQVQLILFGKKFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="140" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B5Z6</accession>
    <accession>C8V5N0</accession>
    <name>Q5B5Z6_EMENI</name>
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        <submittedName>
            <fullName evidence="7">Transcription factor HapC (Eurofung)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ANIA_04034</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2012" name="Structure" volume="20" first="1757" last="1768">
            <title>DNA minor groove sensing and widening by the CCAAT-binding complex.</title>
            <authorList>
                <person name="Huber E.M."/>
                <person name="Scharf D.H."/>
                <person name="Hortschansky P."/>
                <person name="Groll M."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="22902862"/>
            <dbReference type="DOI" id="10.1016/j.str.2012.07.012"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.80 ANGSTROMS) OF 41-132</scope>
    </reference>
    <reference evidence="11 12" key="4">
        <citation type="journal article" date="2020" name="Life. Sci Alliance" volume="3" first="e202000729" last="e202000729">
            <title>Structural basis of HapE&lt;sup&gt;P88L&lt;/sup&gt;-linked antifungal triazole resistance in &lt;i&gt;Aspergillus fumigatus&lt;/i&gt;.</title>
            <authorList>
                <person name="Hortschansky P."/>
                <person name="Misslinger M."/>
                <person name="Morl J."/>
                <person name="Gsaller F."/>
                <person name="Bromley M.J."/>
                <person name="Brakhage A.A."/>
                <person name="Groll M."/>
                <person name="Haas H."/>
                <person name="Huber E.M."/>
            </authorList>
            <dbReference type="PubMed" id="32467317"/>
            <dbReference type="DOI" id="10.26508/lsa.202000729"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.20 ANGSTROMS) OF 41-132</scope>
    </reference>
    <reference evidence="13 14" key="5">
        <citation type="journal article" date="2022" name="Structure" volume="30" first="934" last="946.e4">
            <title>Structural insights into cooperative DNA recognition by the CCAAT-binding complex and its bZIP transcription factor HapX.</title>
            <authorList>
                <person name="Huber E.M."/>
                <person name="Hortschansky P."/>
                <person name="Scheven M.T."/>
                <person name="Misslinger M."/>
                <person name="Haas H."/>
                <person name="Brakhage A.A."/>
                <person name="Groll M."/>
            </authorList>
            <dbReference type="PubMed" id="35472306"/>
            <dbReference type="DOI" id="10.1016/j.str.2022.04.001"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (3.40 ANGSTROMS) OF 41-132</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NFYB/HAP3 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF74841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_661638.1">
        <property type="nucleotide sequence ID" value="XM_656546.2"/>
    </dbReference>
    <dbReference type="PDB" id="4G91">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.90 A"/>
        <property type="chains" value="B=41-132"/>
    </dbReference>
    <dbReference type="PDB" id="4G92">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.80 A"/>
        <property type="chains" value="B=41-132"/>
    </dbReference>
    <dbReference type="PDB" id="6Y37">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.20 A"/>
        <property type="chains" value="B=41-132"/>
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    <dbReference type="PDB" id="6Y39">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.30 A"/>
        <property type="chains" value="B/E/H=41-132"/>
    </dbReference>
    <dbReference type="PDB" id="7AW7">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="3.40 A"/>
        <property type="chains" value="B=41-132"/>
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    <dbReference type="PDB" id="7AW9">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="3.50 A"/>
        <property type="chains" value="B=41-132"/>
    </dbReference>
    <dbReference type="PDBsum" id="4G91"/>
    <dbReference type="PDBsum" id="4G92"/>
    <dbReference type="AlphaFoldDB" id="Q5B5Z6"/>
    <dbReference type="SMR" id="Q5B5Z6"/>
    <dbReference type="STRING" id="227321.Q5B5Z6"/>
    <dbReference type="GeneID" id="2873455"/>
    <dbReference type="KEGG" id="ani:ANIA_04034"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN4034"/>
    <dbReference type="eggNOG" id="KOG0869">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066247_10_0_1"/>
    <dbReference type="InParanoid" id="Q5B5Z6"/>
    <dbReference type="OMA" id="PMDRNTE"/>
    <dbReference type="OrthoDB" id="386949at2759"/>
    <dbReference type="EvolutionaryTrace" id="Q5B5Z6"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016602">
        <property type="term" value="C:CCAAT-binding factor complex"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="AspGD"/>
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    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006109">
        <property type="term" value="P:regulation of carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd22907">
        <property type="entry name" value="HFD_NFYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000039">
        <property type="entry name" value="Nuclear transcription Y subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027113">
        <property type="entry name" value="Transc_fact_NFYB/HAP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003956">
        <property type="entry name" value="Transcrpt_fac_NFYB/HAP3_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11064">
        <property type="entry name" value="CCAAT-BINDING TRANSCRIPTION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11064:SF9">
        <property type="entry name" value="NUCLEAR TRANSCRIPTION FACTOR Y SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00615">
        <property type="entry name" value="CCAATSUBUNTA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00685">
        <property type="entry name" value="NFYB_HAP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="9 10 11" id="KW-0002">3D-structure</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="6">
        <location>
            <begin position="46"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="135"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="149"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="210"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBF74841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="9">
        <source>
            <dbReference type="PDB" id="4G91"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="10">
        <source>
            <dbReference type="PDB" id="4G92"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="11">
        <source>
            <dbReference type="PDB" id="6Y37"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="12">
        <source>
            <dbReference type="PDB" id="6Y39"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PDB" id="7AW7"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="14">
        <source>
            <dbReference type="PDB" id="7AW9"/>
        </source>
    </evidence>
    <sequence length="219" mass="23402" checksum="CD574D720AE7CDC6" modified="2005-04-26" version="1">MSSTSPSKEPEVEQEPQSGEEHEQMDKEQDNQTQGQGEFEVKEQDRWLPIANVARIMKLALPENAKIAKEAKECMQECVSEFISFITSEASEKCQQEKRKTVNGEDILFAMTSLGFENYAEALKIYLSKYRETQSARGEHQNRPPSSGYAGGGPVGGAASGPSVVRAGGAAAGGAFPEASDNAGSIMNQGLDPSEQDASAYGYPPMVGQGHNGAGGESY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="99" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B6D4</accession>
    <accession>C8V6B2</accession>
    <name>Q5B6D4_EMENI</name>
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        <recommendedName>
            <fullName evidence="3">Fumarylacetoacetase-like C-terminal domain-containing protein</fullName>
        </recommendedName>
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    <gene>
        <name evidence="4" type="ORF">ANIA_03896</name>
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    <organism evidence="4 5">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAH family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF75148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_656408.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B6D4"/>
    <dbReference type="STRING" id="227321.Q5B6D4"/>
    <dbReference type="GeneID" id="2873319"/>
    <dbReference type="KEGG" id="ani:ANIA_03896"/>
    <dbReference type="eggNOG" id="KOG1535">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028458_2_0_1"/>
    <dbReference type="InParanoid" id="Q5B6D4"/>
    <dbReference type="OMA" id="HIQEDRA"/>
    <dbReference type="OrthoDB" id="411064at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="entry name" value="Fumarylacetoacetase-like, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820">
        <property type="entry name" value="ACYLPYRUVASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820:SF7">
        <property type="entry name" value="ACYLPYRUVASE FAHD1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="FAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarylacetoacetase-like C-terminal" evidence="3">
        <location>
            <begin position="4"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="Fumarylacetoacetase-like C-terminal" evidence="3">
        <location>
            <begin position="105"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBF75148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="156" mass="16628" checksum="5E3A1EA64BFE3BA9" modified="2005-04-26" version="1">MKLDIPTVPTLFLKPSTSLGDPYPTSSTILPKITQEDGTGDYESEMAIIIGQDAKDVSEEEALDYVLGYTAANDISSRTSQMNQSQWCFSKGFDGACPLGPVVGTTLPAGTVILTGTPPGVGAAKNPKEFLRDGDEFRVELLPFVGTLVSKIKNQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B6P7</accession>
    <accession>C8V710</accession>
    <name>Q5B6P7_EMENI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_03783</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF75394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_661387.1">
        <property type="nucleotide sequence ID" value="XM_656295.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B6P7"/>
    <dbReference type="GeneID" id="2873206"/>
    <dbReference type="KEGG" id="ani:ANIA_03783"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN3783"/>
    <dbReference type="eggNOG" id="ENOG502SG32">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_186262_0_0_1"/>
    <dbReference type="InParanoid" id="Q5B6P7"/>
    <dbReference type="OMA" id="NYKPTEH"/>
    <dbReference type="OrthoDB" id="5279375at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="62"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF75394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="86" mass="9310" checksum="373FBBEF82880E85" modified="2005-04-26" version="1">MVQGSTATGEKYKPSEHGGRREDNQPDKRTQQHQFAYGKVDPHQAGHEGGKVGGHAGGVASGKGSASKYNQQGQEQLEDEEPEYEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="112" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B6V2</accession>
    <accession>C8V7C1</accession>
    <name>Q5B6V2_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">serine C-palmitoyltransferase</fullName>
            <ecNumber evidence="5">2.3.1.50</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">ANIA_03728</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.50" evidence="5"/>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF75518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_661332.1">
        <property type="nucleotide sequence ID" value="XM_656240.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B6V2"/>
    <dbReference type="FunCoup" id="Q5B6V2">
        <property type="interactions" value="866"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5B6V2"/>
    <dbReference type="GeneID" id="2873150"/>
    <dbReference type="KEGG" id="ani:ANIA_03728"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN3728"/>
    <dbReference type="eggNOG" id="KOG1358">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015846_0_2_1"/>
    <dbReference type="InParanoid" id="Q5B6V2"/>
    <dbReference type="OMA" id="ITIRHAI"/>
    <dbReference type="OrthoDB" id="3168162at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004758">
        <property type="term" value="F:serine C-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046512">
        <property type="term" value="P:sphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000059">
        <property type="entry name" value="Serine palmitoyl CoA transferase subunit LcbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050087">
        <property type="entry name" value="AON_synthase_class-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693">
        <property type="entry name" value="CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693:SF2">
        <property type="entry name" value="SERINE PALMITOYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="6 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="11">
        <location>
            <begin position="123"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CBF75518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="504" mass="56105" checksum="9446DC841D1D6C2E" modified="2005-04-26" version="1">MDVQETQRLLSEYLHELANLFHRVPGSAIFLRYVKSSYQNDPIRSAVELFLFLFAVRYLLAPKYSTKPGVVQLSEDEIDDLVDEWTPEPLVGKPTALEEMEIDKRPVIAGPVGPKVRLSNGRTVMNLGSYNFYNFNTNESIKEKAIQTLRNYGVGPCGPRGFYGTQDVHMKTEADVASYLGTASCIIYSQAFSTISSVIPAFSKRGDIIVADKGVNFAIRKGIQISRSIVRWYEHNDMEDLERVLAKITKEQARKPLTRRFIITEGLFESYGDMSDLPKIIELKLKYKFRLILDESWSFGVLGRTGRGITEHQNVDAAEVDMIVGSLAGPLVAGGGFCAGSEEIVHHQRISAAAYTFSAALPALLSTTASATINILQNSPETISHLRDLTKAMWAQLDPRSDWVRCTSAPENPILVLVLKPEVVAAKRLSHEDQQYVLQDVVDECIANGVLITRLKCLDDNFEPKQNVPAALKVCVTTGLTKKEIEKSGTIIRHAITKVLSKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B7W4</accession>
    <accession>C8VHQ8</accession>
    <name>Q5B7W4_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RPEL repeat protein (AFU_orthologue AFUA_7G01340)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ANIA_03366</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
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            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
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    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
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            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
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        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
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        <source>
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<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="97" xmlns="https://uniprot.org/uniprot">
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
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            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
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    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
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                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
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            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
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        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
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        </source>
    </evidence>
    <sequence length="2880" mass="321929" checksum="13434985F26CD53F" modified="2005-04-26" version="1">MTQILHVSPVGWDHMKNHWWQFSRRRPEKVSPRVSAKIDGLANRHLNLANRPTGQKPSSVGIYLGGLDEHLSDYQRRFLDEWDMLIVDPYQSGVVEAVATAAGKQILGRLDLQDVASKEDAALAAIEKIDSALSQVFERSAFSGILLANWENKLSSECWASLLQAIQKLGLSVFLETAPPDFLPDRLVLQNQAISGLVVKNASILPNGQKRDYFQLQSMKSTIKAFVSEACMRDFTVVAWETIDDDASLSNAVVRRSLQWCNFYSAIPWIGCRAALKDVKLNTKLPEPLSSFSWLKEPEIMSAHDRWRANSSIEDVNGVVSSGWDELLPFFPTLSNLIASSERDNGAHEDLTMAIRDPPDWVSLTKSQTNPLSTSIGGLEYNSFGCFPLGAEATAGSFAEILKSQQRLKSLGLLHPVPLAKMQSLATLLRQFHDGFALSAWGSSDPVPGHIKELSNLAANEQLRVYLGLDSGFRKNTDIRFWGVYHMDSEGFDVFVSKKVQGLAGTVLHTYLSAKGCPRHVCFGAETALAKWTKDLVEEIGLPRRLVQDIDVLSPEERLLLLQHLSLTDAPSDLTKSICAYLQQQLIEGTSLVQLKQVNTVSYLEGSASPETLVNSRVKWYREQGCSYPSPSVCLSLFREVEATFPQILKERREADLAQISRGLCQLMQGKQVDAYTDILALALFCAARKGALDEIYQEVTDRNPLFNAHSDQAAAFAESFALGSRCESYFDISPSAFGKLLSDRFRKSYKDGDLPDWINGAPEMATSYAGAQIDVNPDDKVKPMRGYQRFTFLSVFAFPALIDIILLTLIGRGLYLSAFMTYEEQNSATTALMISLLLSGGIGTWIACGGPYYLISMAFAATNMFVFIRLIAGLAFTIAGGLIGFVVVSGVNGPRAGIVFYLYLVALTTYFSGFACLASFSYPGSTFLSGRKIIFACIPILFISPIVTTFTGHDSAIYIAVIYVFIGALILGLRSVASKWVTWYQKLRKTDDTEIRKWYVETYGNGDEKVFGGLSDPAVLKLSREALLKDVTAERNRWFFSRPTTKSTLVLELARDWEATNFLLEWYCRYADVPRPIPYSSGWNTQTKVALESLKAAQRGIRLHNAFIHWRQSSREIGCGMLYFIVALLDKWVELLSGGHLIGLSASLTTAYRMAVGFSLAYYLIGAVLIDTKAQELHSLVGSHTPVPLKTAKDIRDSQKRDVRFKRKVYWKTLGKYLMWHSWGLAFSTALVWTFQSHMEAMVMFLSYVAAYTGLLWYQYTKIFTGPHALKPLLVGSLVGLPLGIALKVCLPHFMYSQVVGLGAATWTVAFLSLIPAKMGMPKRVDSPVELGKTFHAYTAPWDDPDWSQQELQTFYESISLIPSDARLKLVPASHPGSEVKQMLISRRKEPRIEEAFPHSQELVDTALKAWEAGEVLLELVPLGSIGPNVHALSCSTSDHLKIAIAVGRGLDHRIDVSANCQVIAETLLHAVAESIMQIPHEQAVLAESLVAAGVTETTARQLREEADTPLVVRWAKKELLRQLCLGFECDFHWEKLPRAVRKALLDRCLGQPCRLSEKHYRWLEESICQFDIKDLAVHIARSNLAAAAAVSILDYANYGTGESATYKESETPAYIPYLPKQLPTVAYFIMKPLFSVYYKVAIALKFVVVALVADPEFQREYNHVMSPYPAIIRVPATFALSMVWNYAKIMQDLGLTFFLFHGRDNVKQLWDETKGMTINIKKSRYIVQSLDGTFTAFRHNQPDGGFKVYYYTGTPKTEPQGTKSLSCVSTYSKDLLLLIRQEYKGGNIVNEYHYDYRTPTKKGITLKLTDRKVPMGRRCVRGTNHLQSVQYNRKGLIEAGSYMKDGNLIRFKYHYRKNPQFGDELLRAEFALSHITCTVSWCAPPLRHPEKVDRWIPHAKVTEATFVQGPDVYEARWLYDHKFHPTIFTTLNGQKIQTPPMIEHDYLGVLAKPRLTSFVHDNPLFYCDSLSSNIFTRILGLTRKRFPVSISRARSLIWKAWKEKADFDGITVRWMDERLLRRDRTLSPYWRSRDWGDLTSAKKYLELRADTIAASADLDDGISSWTPLAVKVSDLFNFGPGGDAVVNTRSNDFGSDTEKSLHVMAADNGTWPNEGGGVSACRRDMINSLRTIKWHMICESANDFGVPKHQTEQNILSLKVIPLWGMDFLTPTHGLFRNKLDAEVESVTSANDMDIKMNFIPILTALVKGARAVHLSKADIRQATRALVNLNTFFQDSRHWTQIWNSEIVKESWRDLWLTQEMPNTMPSAEWFSTDLPTLGTLDVALELWYRYLFIFSIPIPEKIPSVFQASHHSVSASYGVVCKIKRNCTLQIWDHAIAWRETNLCLSSALCKLSPFVRNALLGLMRVTSALTLYHADIISPCADFFNPGWEVEIGTCQGTIEHRNIFRRKVDPVVNGITDMQKFAPVKEIKSERPTVTMLSHVWYAKDIKTALLAADIIINQWKFDDYHLDIYGAIDKAPTYSTECQEIIASKGLRGRVTLRGTADPMKVLESTWLFLNSSLSEGLPLALGEAALTGAPVVCTDVGASLRVLSDPDDFSRFSAVVAPNDALALARAQISMLALLGEWSQYAEDTEPAPILPSSPTPEDVAKITQRMYDKSEHRRKLGMMTRKIVQKSFSGDRYLREHEQMLWIGKSAKMMATRAPGLHEPADIATAIQQTLPIEEEVITIPRSAVHSWRSSAASGMSTLYTSYTSSTTPFSHLNPNNQPPTRSSYYAPAHTSASANLLTRPSSLYSAISNASTTDASSFLPLPNTPLPVFAPRHSFALPSAPGANGGNGGGISRPLSPAGRRSPLFTRARHSRSRSGSLSTGGREQLRGLQREDLQQYRNSDVSTIMREDFFQSSIYRGIEGGNNQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="108" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B9P6</accession>
    <accession>C8VJZ2</accession>
    <name>Q5B9P6_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">60S acidic ribosomal protein P0</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ANIA_02734</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. uL10 forms part of the P stalk that participates in recruiting G proteins to the ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF84123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_660338.1">
        <property type="nucleotide sequence ID" value="XM_655246.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B9P6"/>
    <dbReference type="FunCoup" id="Q5B9P6">
        <property type="interactions" value="1328"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5B9P6"/>
    <dbReference type="GeneID" id="2874227"/>
    <dbReference type="KEGG" id="ani:ANIA_02734"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN2734"/>
    <dbReference type="eggNOG" id="KOG0815">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053173_1_1_1"/>
    <dbReference type="InParanoid" id="Q5B9P6"/>
    <dbReference type="OMA" id="DMNPFKL"/>
    <dbReference type="OrthoDB" id="10259902at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd05795">
        <property type="entry name" value="Ribosomal_P0_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1730:FF:000002">
        <property type="entry name" value="60S acidic ribosomal protein P0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.105.20:FF:000001">
        <property type="entry name" value="60S acidic ribosomal protein P0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.105.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050323">
        <property type="entry name" value="Ribosomal_protein_uL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001790">
        <property type="entry name" value="Ribosomal_uL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040637">
        <property type="entry name" value="Ribosomal_uL10-like_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043164">
        <property type="entry name" value="Ribosomal_uL10-like_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_uL10-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030670">
        <property type="entry name" value="uL10_eukaryotes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45699">
        <property type="entry name" value="60S ACIDIC RIBOSOMAL PROTEIN P0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45699:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00428">
        <property type="entry name" value="Ribosomal_60s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00466">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17777">
        <property type="entry name" value="RL10P_insert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039087">
        <property type="entry name" value="L10E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="Ribosomal protein L10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL10-like insertion" evidence="7">
        <location>
            <begin position="109"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="287"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="295"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR039087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBF84123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="312" mass="33430" checksum="4D79A6311E984AD4" modified="2005-04-26" version="1">MGGKSATKAAYFEKLKNLLDEYKTVFIVGVDNVSSQQMHEIRIALRGEGVVLMGKNTMVRRALKGFINDNPEYERLLPHVKGNVGFIFTNGDLKETKDKILSNRVAAPARAGAVAPADVWIPAGNTGMEPGKTSFFQALGVPTKIARGTIEITTDLKLVEEGNKVGPSEATLLNMLNISPFTYGMTIQQVYQDGQTFSAAVLDIEEEQLLKVFSSAINTITSISLAVNYPTLPSVIHSVVNSYKKVLAVAVETEYSWPEIEELKDRIANPEAYASAAPAAAAGGAAPAAAAEAAPAEEAEESDEDMGFGLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="107" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B9W8</accession>
    <accession>C8VHD8</accession>
    <name>Q5B9W8_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">amidase</fullName>
            <ecNumber evidence="3">3.5.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ANIA_02662</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a monocarboxylic acid amide + H2O = a monocarboxylate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:12020"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:35757"/>
            <dbReference type="ChEBI" id="CHEBI:83628"/>
            <dbReference type="EC" id="3.5.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amidase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.4" evidence="3"/>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF84256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_660266.1">
        <property type="nucleotide sequence ID" value="XM_655174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B9W8"/>
    <dbReference type="FunCoup" id="Q5B9W8">
        <property type="interactions" value="48"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5B9W8"/>
    <dbReference type="GeneID" id="2873930"/>
    <dbReference type="KEGG" id="ani:ANIA_02662"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN2662"/>
    <dbReference type="eggNOG" id="KOG1212">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009600_9_2_1"/>
    <dbReference type="InParanoid" id="Q5B9W8"/>
    <dbReference type="OMA" id="EPWRPEM"/>
    <dbReference type="OrthoDB" id="6428749at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004040">
        <property type="term" value="F:amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043605">
        <property type="term" value="P:amide catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1300.10:FF:000003">
        <property type="entry name" value="Amidase signature enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072:SF11">
        <property type="entry name" value="AMIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072">
        <property type="entry name" value="AMIDASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001221">
        <property type="entry name" value="Amidase_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="7">
        <location>
            <begin position="75"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="206"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="5">
        <location>
            <position position="230"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="227"/>
            <end position="230"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBF84256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="536" mass="58334" checksum="2C605D9032DD38F6" modified="2005-04-26" version="1">MSWESVAAKKRQALKNAIPPEWVIPAEIFPPEDQLDVTNFPKDSGFFTDRELEITSTPAQGILDRLASGSWTAEEVTRTFCKTAAVAQQLTNCLSEILFDRAIAQAKELDAYYRETGKTKGPFHGLPISIKDNFNLIGVDATVGFTSLVDDPATYNSTLVDLLLGAGAVLYCKTNVPTAMMIAETVNNVFGRTVNPRNRKLTSGGSSGGESALIAFGGSRIGVGTDIGGSLRIPAACTGIFTIRPSFGRFPNFQTRSGLAGQEAVNSVNGPMAKTLEEIVLWARTVVGQQPWLTDPKCLPIPWRDVEVKKTLKIGVLHHDGLVTPTPPVTRALNETVQKLKDAGHKVVTWAPTEHKDLLTTLAKFFVADGGKSIRKLLEPTSEPFCPEMKAYEDAAELGVHEMWQLHLKRNALCKSYLDRWNASGIDAVLCPVTPYSTVEHGKFAYVGYTGVFNVLDYPGVSFPCGVKADKDIDKSYVNHQPLTDIDAQIQNDYSAESVHGMPVSLQLVGRRLEDERVLAITDAILRAIASSNGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="102" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BA33</accession>
    <accession>C8VKL7</accession>
    <name>Q5BA33_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Zn(II)2Cys6 transcription factor (Eurofung)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ANIA_02597</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF87170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_660201.1">
        <property type="nucleotide sequence ID" value="XM_655109.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BA33"/>
    <dbReference type="GeneID" id="2875258"/>
    <dbReference type="KEGG" id="ani:ANIA_02597"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN2597"/>
    <dbReference type="HOGENOM" id="CLU_024934_0_3_1"/>
    <dbReference type="InParanoid" id="Q5BA33"/>
    <dbReference type="OMA" id="WATDIVG"/>
    <dbReference type="OrthoDB" id="4937900at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053157">
        <property type="entry name" value="Sterol_Uptake_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784">
        <property type="entry name" value="STEROL UPTAKE CONTROL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784:SF8">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="13"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="45"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="63"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="76"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="102"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="241"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBF87170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="431" mass="47951" checksum="D3AA58E90027AFA4" modified="2005-04-26" version="1">MPVQRRLRKSPLECAQCAEGQMECSKARPQCDECKSQHLTCRYRDQKPAPYRTKAAAAAESPVYSSPSPTIYHRQSNASSTSTSSQSTESNTSTESNTSSESRNDECAEAPEKPESCHVQGSGLGDVRLWDNWRSSTERSLIHNKSKDQSWQVLIRRESDRYPALRHSTLALSAIQLAYTSEAGSDKRKAYLQEADAHYSQAVAAVTPVAEKPSGSRCNAAFSTASILLMYELASASLAEGGDKSSPRKDDEQGTSSPSLHKLLDMFNTVRGLSSSSEVIDKVERGELKALFTQTDPYHQLPSTYTLTILAMRNLNNASAKKDPSHETSIYDDAISKLDRSLEMLSKGGEPTMIALRWLFRLPSRYLDLVREQQPLALTIFAHYCAVLHHLRDRWWMGDWGCRLVKEISQLLGPERLGSILWASDIVGIQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="122" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BA40</accession>
    <accession>C8VKL0</accession>
    <name>Q5BA40_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">L-lactate dehydrogenase (cytochrome)</fullName>
            <ecNumber evidence="17">1.1.2.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Cytochrome b2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Flavocytochrome b2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">L-lactate ferricytochrome c oxidoreductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">ANIA_02590</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="25" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="25">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>(S)-lactate + 2 Fe(III)-[cytochrome c] = 2 Fe(II)-[cytochrome c] + pyruvate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:19909"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16651"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.1.2.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:19910"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">In the C-terminal section; belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="16">In the N-terminal section; belongs to the cytochrome b5 family.</text>
    </comment>
    <dbReference type="EC" id="1.1.2.3" evidence="17"/>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF87158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_660194.1">
        <property type="nucleotide sequence ID" value="XM_655102.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BA40"/>
    <dbReference type="STRING" id="227321.Q5BA40"/>
    <dbReference type="GeneID" id="2875480"/>
    <dbReference type="KEGG" id="ani:ANIA_02590"/>
    <dbReference type="eggNOG" id="KOG0537">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0538">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020639_1_1_1"/>
    <dbReference type="InParanoid" id="Q5BA40"/>
    <dbReference type="OMA" id="CWTRDAN"/>
    <dbReference type="OrthoDB" id="1925334at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004460">
        <property type="term" value="F:L-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02922">
        <property type="entry name" value="FCB2_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000009">
        <property type="entry name" value="Cytochrome b2, mitochondrial, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000062">
        <property type="entry name" value="Cytochrome b2, mitochondrial, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037458">
        <property type="entry name" value="L-MDH/L-LDH_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578:SF104">
        <property type="entry name" value="CYTOCHROME B2, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578">
        <property type="entry name" value="S -2-HYDROXY-ACID OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0288">FMN</keyword>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="12" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="22">
        <location>
            <begin position="8"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="23">
        <location>
            <begin position="111"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00052399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00061137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00061589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00066458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00068515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00075949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00078774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00078938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="CBF87158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="488" mass="53746" checksum="A87DAD59AD03DFC7" modified="2005-04-26" version="1">MDKDSNEIPLLSVQEILSHNTPNDCWVVIQGEVWDLTAFANEHPGGPSVILKYAGRDATDAFLGIHAPTIIRENLSSGHFKGRLDTSTITPGWTQITQKAQPTGQPRQPKPPLASLINSYDFEKAAAVSASEKAYTFYSTADTDCWTRDANESMLKRIWFRPRVMRDVASVDTSTSMLGIQMSIPLFICPAGVGSLINPDAEKALARAAESTGIVEIISTNSAHPLADIVEQAPGYPFLFQLYLNKQRQKSKELLLKAESLGCRAIFLTVDSAGRGKRESDERLKSDEMLRDPVTGKLMKAGAGLTRIMGSFIDQGMTWKDLAWIRSVTKLPIILKGITSAEDAKIAMQYKVDGILLSNHGGRNLDYSPPTILLLLELHKNCPEIFDKMEIYVDGGFRRGADIIKALCLGAKAVGMGRSFLYALNYGTEGVEHLIQLLKAEMEAVMKLIGIKDLSEVYPGLVNTADVDHLVPSGPNHPYIKWRMRSNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BAR8</accession>
    <accession>C8VNG7</accession>
    <name>Q5BAR8_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4246 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_02362</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF86691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_659966.1">
        <property type="nucleotide sequence ID" value="XM_654874.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BAR8"/>
    <dbReference type="STRING" id="227321.Q5BAR8"/>
    <dbReference type="GeneID" id="2875032"/>
    <dbReference type="KEGG" id="ani:ANIA_02362"/>
    <dbReference type="eggNOG" id="ENOG502QQIE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012066_2_1_1"/>
    <dbReference type="InParanoid" id="Q5BAR8"/>
    <dbReference type="OMA" id="MMRIMNI"/>
    <dbReference type="OrthoDB" id="415532at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025340">
        <property type="entry name" value="DUF4246"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049192">
        <property type="entry name" value="DUF4246_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33119:SF1">
        <property type="entry name" value="FE2OG DIOXYGENASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33119">
        <property type="entry name" value="IFI3P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14033">
        <property type="entry name" value="DUF4246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4246" evidence="2">
        <location>
            <begin position="148"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF86691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="347" mass="39854" checksum="410271C8807878AF" modified="2005-04-26" version="1">MMRIMNIITENPDRRLKLFDKRITTKWREEVAQSAQDVSARMMHWIIAELKWKADILRDTGFGKVFDDSVVNRDLFGDRIKFKGVEPENDTCPPPEGPRDDAEDYDFDHFEERRAECHKTLISGGQLPEAFSEPKVSSDCEIGEHYVDARKPEYEGGTWHIEGQLNERIAVSAIYYYDSHNITASALALRHRGMSGMYGVIHEQDMHHFLQQTYGFPEDVDGRNEVLITQDLGSVDTTEGRLITFPNTLQHRVSVSLADRSKPGHRKILALFFLDPHHRIISSANVLPQREDWRRTGNRASGYAHGTTTMTMEEAKALRLELMEERGHSSQESNNSFEMGEFSLCEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="107" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BAT4</accession>
    <accession>C8VNE9</accession>
    <name>Q5BAT4_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ANIA_02346</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF86658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_659950.1">
        <property type="nucleotide sequence ID" value="XM_654858.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BAT4"/>
    <dbReference type="STRING" id="227321.Q5BAT4"/>
    <dbReference type="GeneID" id="2875144"/>
    <dbReference type="KEGG" id="ani:ANIA_02346"/>
    <dbReference type="eggNOG" id="KOG4177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_505287_0_0_1"/>
    <dbReference type="InParanoid" id="Q5BAT4"/>
    <dbReference type="OMA" id="RIYLHWA"/>
    <dbReference type="OrthoDB" id="4772757at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="50"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="83"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="178"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="316"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="416"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="361"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="364"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBF86658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="539" mass="60248" checksum="772CB784FC7CEAAF" modified="2005-04-26" version="1">MLFLDLPDELLLFVGEVIPLQRDLSSLTKTNRRLYCLLSDLLLKINMKDSNSSALVYAAQHGNLAVVQRMVELGADINATNPDAYTVLDCAASEGHADIVRYLLRKGASHRFTVERPSVSNVSQRTVQNMFTTNVSKEEQETLEYTIPLFLAILHSHDEAALSLIEDQRVNINYCDLWGRTPLMWALTCGRRKLVRALLQHGANANVHDEHSGLTVLIAEIRRPKARHVRLLLAHDKVDPNLPDRHSCTPLWAALDSWDVTMLKQLLARHDLDVNKTRNGITPLLHAISNKQEDVAILLLKHPNLDSSSINSMDANERTPLSYASEYGQVWLTDMLLEKGADSQLTDVDGRVPRSYAAARVETQAATSPTQTEQVQADSGEVPAQAPIFLSIDHGRLDTLETLVSLGADPSQQNEDGHTPLHCLVKRSGRQPVLAPEDEQAIRYLLEHGADPWIKDKCGMTVLDMARAYGWGELMGGILRSSFRRIRGEDSHGSWEDANIPPMSEGCAAAGMCWTQRRTWRIGVGYESDWVESREPWRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BBE4</accession>
    <accession>C8VM70</accession>
    <name>Q5BBE4_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Zn(II)2Cys6 transcription factor (Eurofung)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ANIA_02136</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF86252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_659740.1">
        <property type="nucleotide sequence ID" value="XM_654648.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BBE4"/>
    <dbReference type="GeneID" id="2875395"/>
    <dbReference type="KEGG" id="ani:ANIA_02136"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN2136"/>
    <dbReference type="eggNOG" id="ENOG502SAWI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011074_1_0_1"/>
    <dbReference type="InParanoid" id="Q5BBE4"/>
    <dbReference type="OMA" id="SMENILH"/>
    <dbReference type="OrthoDB" id="4150467at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="601"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="152"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="417"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="663"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="170"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="188"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="206"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="270"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="300"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="350"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="417"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="478"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="533"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBF86252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="687" mass="74466" checksum="B5652CE80159F242" modified="2005-04-26" version="1">MQAVQNEQLVSPGESPTYTDHRPLQEPSPTKSPTPKNVAFELLLDDNSKARARIPMRVQIYPHDTTDSIVTTVKNFYGIYDGAAGVSFEDVNGITLIARYENLRNNMTVYVRVMPVPVYEEGYGDRYYGPMSMDNRKRPSLGEPFQMASAMQPIQHPEHGQSPSRPASRVARKRSVSPSGKSRRSASQHKQQSRPGLKSRGSSTHGSIYDDAGYSDSDGGYGSVSGAKKSRSEHFASSEISMENILQDGRRKRPKFESSELPLFVPPQVPLTTSTSSISPQRRSIGQEGAGSPFARPMHRSNNYYQQPLPSPQSYGHNDHIYGGNTSRNGIYTTPMVPEHGHRLRDRATVHSSGQYPNSTGRNGGPGILPTPDPTIASCISDEDVALQLIRLGDASNFSHGRTSASTLDDAFSGAADAASSTGATSDGEGYSEDDDDLPARPRQRLDSSPMLPPGTAKHTHKRLDDILPSFDSSDASYDSHDNEYHQEDYEGGMVKNEVDDDSSHESMSKPKKAKSRNTSTTSSKPRAGKTPQIRSGKSANKPASNNGARKGAKSTPSAPGHKVGPLQTANAAAPRKASTSSVNGQYPLAADEEDLSTKPRCQRCRKSKKGCDRQRPCGRCKDAGIGIEGCISEDEGNGRKGRYGRHMGVPVKKPLDTVPVANETQSSIPAVPMAASTVDKNKKRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="123" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BCN0</accession>
    <accession>C8VNV0</accession>
    <name>Q5BCN0_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">26S proteasome regulatory subunit RPN2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ANIA_01700</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the proteasome subunit S1 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF85394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_659304.1">
        <property type="nucleotide sequence ID" value="XM_654212.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BCN0"/>
    <dbReference type="FunCoup" id="Q5BCN0">
        <property type="interactions" value="1368"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5BCN0"/>
    <dbReference type="GeneID" id="2874940"/>
    <dbReference type="KEGG" id="ani:ANIA_01700"/>
    <dbReference type="eggNOG" id="KOG2062">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002323_0_1_1"/>
    <dbReference type="InParanoid" id="Q5BCN0"/>
    <dbReference type="OMA" id="IMFGRQE"/>
    <dbReference type="OrthoDB" id="261572at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
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    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004175">
        <property type="term" value="F:endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042176">
        <property type="term" value="P:regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000017">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016642">
        <property type="entry name" value="26S_Psome_Rpn2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002015">
        <property type="entry name" value="Proteasome/cyclosome_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048570">
        <property type="entry name" value="PSMD1_RPN2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040623">
        <property type="entry name" value="RPN2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943:SF2">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13646">
        <property type="entry name" value="HEAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01851">
        <property type="entry name" value="PC_rep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18004">
        <property type="entry name" value="RPN2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21505">
        <property type="entry name" value="RPN2_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015947">
        <property type="entry name" value="26S_Psome_Rpn2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 10" id="KW-0647">Proteasome</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="26S proteasome non-ATPase regulatory subunit 1/RPN2 N-terminal" evidence="9">
        <location>
            <begin position="6"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="26S proteasome non-ATPase regulatory subunit 1/RPN2 N-terminal" evidence="9">
        <location>
            <begin position="211"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="26S proteasome regulatory subunit RPN2 C-terminal" evidence="8">
        <location>
            <begin position="888"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="133"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="371"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="946"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1088"/>
            <end position="1144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="371"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="977"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="989"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1105"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1119"/>
            <end position="1130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR015947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF21505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBF85394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="1144" mass="125639" checksum="1E5227829C21D4BC" modified="2005-04-26" version="1">MVGLASAAGLVGFLSEPDSELKVFALQTLDSQIDLLWTEVVDAIPQIRRLCGNGYQTNIQFLREALYEDEDFPERELAALVAAKVYYHLQEYHESMVFALGAGKLFNLDNGGEFEETIIAKCVDTFISLSTSERPSAGDQPTNLNTAFPTSVEGASSTSASLTSPITPFSQSALPSKSLLSRQEVTGVDGAHPGAEETGSNVEVPLVLKRGVQGQLKAVIERLFEQCFLQKRYRQVIGIAIEAKDLEVLRTAIMRASEDAKQQNGESRQSEELMEYVLDICMGVVQERGFRNEILKLILELLNEIPSPDYFAIAKCVVYLNEHSMASVILRQLVEKGDARSLAVAYQISFDLYDNSTQEFLQKVHQEISELVPEKTEDSETKEEEPKESDALLDNQSSSIGANADSKVSAEARTAFKNILDILDGIKTIQLNMEFLHRNSRVDIAILNKLRDTLEPRNSIFHSAITISNGFMYAGTAQDKFFRDNLEWLGKAVNWSKFTATAALGVIHRGNLSQGQRLLQPYLPKENSIDGVGNSGSLYSQGGSLYALGLIYANHGGMAVDYIRDQFKKATEEVIQHGGALGLGVAGMATGDEGIYDDLRNVLYTDSALNGEAVGLAMGLVMLGTGNMKVLEDMIQYAHDTQHEKIVRGLAMGMALIMYGRQEAADELINGLLGDPDPTLRYGGIMTIALAYCGTSSNKAVRKLLHVAVSDVNDDVRRVAVLSLGFILFRKHQSVPRMVELLSESYNPHVRYGAAMALGISCAGTGLDEAIDLLEPMLKDSTDFVRQGALIALAMVLVQQNEAMNPRVSSLRKTMMKMVSDRHEDAMAKFGCAIALGIIDAGGRNCTISLQTQTGNLNMPGIVGAAVFLQYWYWFPLTHFLSLSFAPTSVIGVDQKLEVPFFKFHSNTRPSLFDYPPEQQVKAEEAPEKVKTAVLSTTALAKRRALRREKQHRRESMDVDQTPTTPKVADQMPEKMETDEDKGDEELKEGDKEAVEGQKKKAEREKVGYELENMSRVLPAQLKYLTFPDPRYEPVKRPTGGVVVVLDKTPEEPRDVIELKASKETKQPALATESAVPADLQARLAEFTDPSRLLATPRRPENPLSGSGAAAAAGVLTAVDEDEDGEEAPVPEEFGYTSEGEAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="108" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BCN3</accession>
    <accession>C8VNU7</accession>
    <name>Q5BCN3_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">mRNA-capping enzyme subunit beta</fullName>
            <ecNumber evidence="8">3.6.1.74</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">mRNA 5'-phosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">mRNA 5'-triphosphate monophosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ANIA_01697</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">First step of mRNA capping. Converts the 5'-triphosphate end of a nascent mRNA chain into a diphosphate end.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 5'-end triphospho-ribonucleoside in mRNA + H2O = a 5'-end diphospho-ribonucleoside in mRNA + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67004"/>
            <dbReference type="Rhea" id="RHEA-COMP:17164"/>
            <dbReference type="Rhea" id="RHEA-COMP:17165"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:167616"/>
            <dbReference type="ChEBI" id="CHEBI:167618"/>
            <dbReference type="EC" id="3.6.1.74"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:67005"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterodimer. The mRNA-capping enzyme is composed of two separate chains alpha and beta, respectively a mRNA guanylyltransferase and an mRNA 5'-triphosphate monophosphatase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the fungal TPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.74" evidence="8"/>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF85389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_659301.1">
        <property type="nucleotide sequence ID" value="XM_654209.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BCN3"/>
    <dbReference type="FunCoup" id="Q5BCN3">
        <property type="interactions" value="60"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5BCN3"/>
    <dbReference type="GeneID" id="2875544"/>
    <dbReference type="KEGG" id="ani:ANIA_01697"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN1697"/>
    <dbReference type="eggNOG" id="ENOG502RZAX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018004_4_0_1"/>
    <dbReference type="InParanoid" id="Q5BCN3"/>
    <dbReference type="OMA" id="YFAQQRS"/>
    <dbReference type="OrthoDB" id="272147at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031533">
        <property type="term" value="C:mRNA capping enzyme complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140818">
        <property type="term" value="F:mRNA 5'-triphosphate monophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004651">
        <property type="term" value="F:polynucleotide 5'-phosphatase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006370">
        <property type="term" value="P:7-methylguanosine mRNA capping"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd07470">
        <property type="entry name" value="CYTH-like_mRNA_RTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.100.10:FF:000002">
        <property type="entry name" value="mRNA capping nucleoside-triphosphatase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.100.10">
        <property type="entry name" value="mRNA triphosphatase Cet1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040343">
        <property type="entry name" value="Cet1/Ctl1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033469">
        <property type="entry name" value="CYTH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004206">
        <property type="entry name" value="mRNA_triPase_Cet1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037009">
        <property type="entry name" value="mRNA_triPase_Cet1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28118:SF1">
        <property type="entry name" value="POLYNUCLEOTIDE 5'-TRIPHOSPHATASE CTL1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28118">
        <property type="entry name" value="POLYNUCLEOTIDE 5'-TRIPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02940">
        <property type="entry name" value="mRNA_triPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55154">
        <property type="entry name" value="CYTH-like phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0506">mRNA capping</keyword>
    <keyword evidence="4 8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="mRNA triphosphatase Cet1-like" evidence="10">
        <location>
            <begin position="480"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="443"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="46"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="125"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="137"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="166"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="192"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="324"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="351"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="443"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CBF85389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="765" mass="83607" checksum="394F927B05F47395" modified="2005-04-26" version="1">MDLRTIMNSEAAGTSQRPPSPTLHRSPPQLTRKPSEPTYPAHEQFPSSSSSSSYPSGYPNGPAQQPAPLQRSQTSPDRAPSYGSLQSPYQYNSTGAQSQRGHTPPAAPYGASASRESFTAPANYPPQHHQSHQQSPTAPQRSQSIQSVLSPYPPASHSYPRRENSPAASQHPYPSQQFSPPAAQGSLPGTPRGSTTALYHQSTPSSARPQSSGRDSLSNRASSPWVNQDGQMHMSPTAVPRASRHDYRAFDNTPQRASLVTERRESDENVSPKTAFPPGSRRDSVAGSEQAALSQLHDKGNSIAAQGNRTFDRNSHPLGGPTASIASQVNSPPSRGSLPNESPKEQQGPPRSSKASSVSESVRANSSPQPPKAKRRRYNEPPIYAQRTSRTKGRCPMIPNPLPPVPKHLRNSAQNPWVLRQQAASQAPPATKIKREGSVVVGPPALQQSQPSRPSQSAEPPEMKSLGPWEPSITGLEPFEEITKTICDFLFQHVVLRNDAIAGPPGATAQGQGAIVEVEAKLGHIIDLDRGERLRLPIMTESIITRERIRTSFESNMTLAQHRAMNNFLNEAVKNSMPQANPKRIPLSYAHKKERDSFYEVSPAELPPVIRQNLNPRHKPKVRVTVDQRTGEVLAKIVKCRVADLDIHSPLTAVDWRVSVNLEMNYDGDISHLTPADTGRGRASDRNKDRMSYRHLAYQVDLTQVARSEPSAKGEFEHELEVEVSAAEIRRQGQLAIAGDPNNQYQDLVKGLVDNVRILARAVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="108" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BD69</accession>
    <accession>C8VMP2</accession>
    <name>Q5BD69_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Peroxisomal membrane protein PEX13</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Peroxin-13</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">ANIA_01511</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="18">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="13">Interacts (via SH3 domain) with PEX14 (via SH3-binding motif); forming the PEX13-PEX14 docking complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peroxin-13 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF85013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_659115.1">
        <property type="nucleotide sequence ID" value="XM_654023.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BD69"/>
    <dbReference type="FunCoup" id="Q5BD69">
        <property type="interactions" value="165"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5BD69"/>
    <dbReference type="GeneID" id="2874712"/>
    <dbReference type="KEGG" id="ani:ANIA_01511"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN1511"/>
    <dbReference type="eggNOG" id="KOG3875">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034386_1_2_1"/>
    <dbReference type="InParanoid" id="Q5BD69"/>
    <dbReference type="OMA" id="EGWFPKK"/>
    <dbReference type="OrthoDB" id="10037838at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990429">
        <property type="term" value="C:peroxisomal importomer complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0000266"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016560">
        <property type="term" value="P:protein import into peroxisome matrix, docking"/>
        <property type="evidence" value="ECO:0000266"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006625">
        <property type="term" value="P:protein targeting to peroxisome"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="CDD" id="cd11771">
        <property type="entry name" value="SH3_Pex13p_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000128">
        <property type="entry name" value="Peroxisomal membrane protein (Pex13)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007223">
        <property type="entry name" value="Peroxin-13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035463">
        <property type="entry name" value="Pex13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19332">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19332:SF1">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04088">
        <property type="entry name" value="Peroxin-13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 14" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SH3" evidence="16">
        <location>
            <begin position="310"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="380"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="13"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="380"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00065871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CBF85013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="436" mass="45791" checksum="E720A765C03E3571" modified="2005-04-26" version="1">MASVSPPKPWERAGATAGTALSSPATTSTAMSSTSTTSAAPTAGTSTTSATAPPSLPSRPSTLSTVANQNASNYSPYGASRFGASPYGGYGGYGSYSSPYSRFGGMGSMYGGYGGYGGMYSGMGGYGGMYGGGMPGDPNDPNSLTNSFNQSTQATFQMIESIVGAFGGFAQMLESTYMATHSSFFAMVSVAEQFGNLRNTLGSALGIFTLIRWFKTLIAKITGRPPPADATALTPAAFAAFMGGRATLPDGSPAPPRPSRKPFLMFLVALFGLPYLMGKLIKSLARSQEAQRQKIMMTANGEQQGVLDPSKLDFCRVLYDYTPESQETNGIDLAVKKGDIVAVLSKSDPMGNASEWWRCRARDGRVGYLPGPYLETIQRKPQQQALTSGSEAGSRSNTMQSQTQVGNEVAAGQKPELKGKMGDISAESFQKSAFYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="103" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BEF0</accession>
    <accession>C8VTM2</accession>
    <name>Q5BEF0_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Translation initiation factor eIF4E, putative (AFU_orthologue AFUA_1G12130)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ANIA_01080</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the eukaryotic initiation factor 4E family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF88186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_658684.1">
        <property type="nucleotide sequence ID" value="XM_653592.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BEF0"/>
    <dbReference type="STRING" id="227321.Q5BEF0"/>
    <dbReference type="GeneID" id="2876855"/>
    <dbReference type="KEGG" id="ani:ANIA_01080"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN1080"/>
    <dbReference type="eggNOG" id="KOG1669">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043552_5_0_1"/>
    <dbReference type="InParanoid" id="Q5BEF0"/>
    <dbReference type="OMA" id="LPLQYHW"/>
    <dbReference type="OrthoDB" id="17977at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016281">
        <property type="term" value="C:eukaryotic translation initiation factor 4F complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006413">
        <property type="term" value="P:translational initiation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.760.10:FF:000016">
        <property type="entry name" value="Translation initiation factor eIF4E, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.760.10">
        <property type="entry name" value="RNA Cap, Translation Initiation Factor Eif4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023398">
        <property type="entry name" value="TIF_eIF4e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001040">
        <property type="entry name" value="TIF_eIF_4E"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960:SF66">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E TYPE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01652">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55418">
        <property type="entry name" value="eIF4e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5 7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0810">Translation regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBF88186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="237" mass="27764" checksum="613E12509A65DFE8" modified="2005-04-26" version="1">MPTPRMDTPELRVQQPSPTEDTTKETTDRSPATRRTLHQNILGKLRPLPLQYHWTFWYDKHSGAESASSTDYDERLYVLYEDVADIATFYRIYNNYPWEKIPQRDTVHIFRKGVRPVWEDPENVKGGCWRFRVPKRKAQAFFHEIAILCISSEFQAALEKEHDHVLGVSTSVRFNTHLISVWNKLGSNERSIKLLEETILNRLSPNLRPTDSGPNSYFYRRHNENEGFQQAVEGSKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="102" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BEF2</accession>
    <accession>C8VTM6</accession>
    <name>Q5BEF2_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ANIA_01078</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF88194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_658682.1">
        <property type="nucleotide sequence ID" value="XM_653590.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BEF2"/>
    <dbReference type="FunCoup" id="Q5BEF2">
        <property type="interactions" value="208"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5BEF2"/>
    <dbReference type="GeneID" id="2876851"/>
    <dbReference type="KEGG" id="ani:ANIA_01078"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN1078"/>
    <dbReference type="eggNOG" id="KOG0016">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009834_6_2_1"/>
    <dbReference type="InParanoid" id="Q5BEF2"/>
    <dbReference type="OMA" id="VVWPKIR"/>
    <dbReference type="OrthoDB" id="448450at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004165">
        <property type="term" value="F:delta(3)-delta(2)-enoyl-CoA isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000048">
        <property type="entry name" value="3,2-trans-enoyl-CoA isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051053">
        <property type="entry name" value="ECH/Chromodomain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43684">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43684:SF1">
        <property type="entry name" value="ENOYL-COA DELTA ISOMERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBF88194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="267" mass="29421" checksum="9201E9F7877087BA" modified="2005-04-26" version="1">MAEEDLVRLDINGIFAVITLNNPRKFNALTQSLYYRLASLLRAAEENPDVYVTVLIGEGPFFSAGADLKGKPPSMEEMLSRPYWLPKLVNNNVDVARAFYSHSKILVTALNGPVIGLSAALISHSDFIYAVSNAYLMTPFTSLGLVAEGGSSVAFVQRMGQGKANEALLLGRKIPVSELAQVGFVNKVFEDKGNFREQVMGYLQQIFGEHLVKSSLLETKALMRRRLVREQDEQAPLEMFGGLDRFCQGVPQAKMGEALSKSKSSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="124" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BEI5</accession>
    <accession>C8VTW3</accession>
    <name>Q5BEI5_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RNA-binding La domain protein (AFU_orthologue AFUA_1G12590)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ANIA_01045</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF88265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_658649.1">
        <property type="nucleotide sequence ID" value="XM_653557.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BEI5"/>
    <dbReference type="FunCoup" id="Q5BEI5">
        <property type="interactions" value="664"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5BEI5"/>
    <dbReference type="GeneID" id="2876822"/>
    <dbReference type="KEGG" id="ani:ANIA_01045"/>
    <dbReference type="eggNOG" id="KOG0118">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043291_2_0_1"/>
    <dbReference type="InParanoid" id="Q5BEI5"/>
    <dbReference type="OMA" id="PKPQWKG"/>
    <dbReference type="OrthoDB" id="439993at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08029">
        <property type="entry name" value="LA_like_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12291">
        <property type="entry name" value="RRM1_La"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045180">
        <property type="entry name" value="La_dom_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006630">
        <property type="entry name" value="La_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002344">
        <property type="entry name" value="Lupus_La"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792:SF140">
        <property type="entry name" value="ACHILLES, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792">
        <property type="entry name" value="LUPUS LA PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05383">
        <property type="entry name" value="La"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00302">
        <property type="entry name" value="LUPUSLA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00715">
        <property type="entry name" value="LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50961">
        <property type="entry name" value="HTH_LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="HTH La-type RNA-binding" evidence="7">
        <location>
            <begin position="99"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="208"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="299"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="39"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="67"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="326"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="378"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBF88265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="400" mass="44932" checksum="DC7BB8C574616153" modified="2005-04-26" version="1">MADEQKPVTAQATNAEAEKDVQNVLAELKGEAEVPVNGTEKEEAKEASADKSEEAEEARIVAAAAKLGEKSEKSENGNQAEDRGRANRRRNESKFDPSTQKETDDPVEIRKQVEFYFSDSNLPMDKFLLSKVGGSKNNPVPLELLHSFKRMRRFQPFSAIVEALKNSETLELTDNDTAVRRKVPLPETVKDTHDPTVVKVFEDKAMARSIYAKGFGEETPTTQLDIEAFFAPYGPINAIRLRRTNEKYFKGSVFVEFASEEKQKAFLELDPMPKWKDQELIIKSKKDYCDEKVREIEAGRVKPSGGRGRGGARGRGGRGGRGGRGGRRDNNRDWRERRDADQKQGFKNGQDEQPERREVQKDARYSGVPVVQSTADAGQKRTREDEASAEHPAKKVDTKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="123" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BEV8</accession>
    <accession>C8VUP9</accession>
    <name>Q5BEV8_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Coatomer subunit delta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">ANIA_00922</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 10">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10 11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10 11">Cytoplasmic vesicle</location>
            <location evidence="10 11">COPI-coated vesicle membrane</location>
            <topology evidence="10 11">Peripheral membrane protein</topology>
            <orientation evidence="10 11">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10 11">Golgi apparatus membrane</location>
            <topology evidence="10 11">Peripheral membrane protein</topology>
            <orientation evidence="10 11">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the adaptor complexes medium subunit family. Delta-COP subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF88519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_658526.1">
        <property type="nucleotide sequence ID" value="XM_653434.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BEV8"/>
    <dbReference type="FunCoup" id="Q5BEV8">
        <property type="interactions" value="1128"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5BEV8"/>
    <dbReference type="GeneID" id="2876697"/>
    <dbReference type="KEGG" id="ani:ANIA_00922"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN0922"/>
    <dbReference type="eggNOG" id="KOG2635">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019988_3_0_1"/>
    <dbReference type="InParanoid" id="Q5BEV8"/>
    <dbReference type="OMA" id="VQFRTHP"/>
    <dbReference type="OrthoDB" id="10266042at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051645">
        <property type="term" value="P:Golgi localization"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd09254">
        <property type="entry name" value="AP_delta-COPI_MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14830">
        <property type="entry name" value="Delta_COP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000003">
        <property type="entry name" value="Coatomer subunit delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027059">
        <property type="entry name" value="Coatomer_dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10121">
        <property type="entry name" value="COATOMER SUBUNIT DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10121:SF0">
        <property type="entry name" value="COATOMER SUBUNIT DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5 10" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="7 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MHD" evidence="13">
        <location>
            <begin position="277"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="154"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="242"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU366052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CBF88519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="516" mass="57253" checksum="9B28A60BB648FCB3" modified="2005-04-26" version="1">MVVLAASICTRGGKAVLSRQFREIARSRVEALLASFPKLADSGTQHTTVEQDNVRFVYQPLDELYIVLITNRQSNILQDIDSLHLFAQVTTSICKSLDEREILRNAFELLSAYDELVTLGYRENLSLSQIKTFLEMESHEERIQEIIERNKELEASEERKRKAKQLEMQRKEAARNSRNIAPRAPSYPVYTPPSRPAVPDTYDSYEAEKKKTFAKPLPTRGKGMQLGKKSKTTDIYEKVRGDLGPEAEESSPLVTPQASTPVAERVSSARPSLSADRDPIHITIAETISASLTRDGALKSFEVKGDLQLRISDPAFTKLRLDLLANPTHGAQFRTHPNVDKAAFSNSSIIQLKDTSKRFPANNSIGVLRWRVAGSGSDNADVLPITFTVWLNKGSDSTTVTVEYELTGSDSLRDVVVTIPYGTAEPAVSSFDAVYEVSGDSLDWNIGNVDENNASSSFEFESTADDENEFFPMTVRFSKASPFVEVDVTNISLIEEGESTGYSKDIKSVAEGYLIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="119" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BEX9</accession>
    <accession>C8VUS1</accession>
    <name>Q5BEX9_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ANIA_00901</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF88560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_658505.1">
        <property type="nucleotide sequence ID" value="XM_653413.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BEX9"/>
    <dbReference type="STRING" id="227321.Q5BEX9"/>
    <dbReference type="GeneID" id="2876668"/>
    <dbReference type="KEGG" id="ani:ANIA_00901"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN0901"/>
    <dbReference type="eggNOG" id="KOG1263">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006504_5_0_1"/>
    <dbReference type="InParanoid" id="Q5BEX9"/>
    <dbReference type="OMA" id="YGAIYIH"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052716">
        <property type="term" value="F:hydroquinone:oxygen oxidoreductase activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042440">
        <property type="term" value="P:pigment metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd13850">
        <property type="entry name" value="CuRO_1_Abr2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13876">
        <property type="entry name" value="CuRO_2_Abr2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13898">
        <property type="entry name" value="CuRO_3_Abr2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000036">
        <property type="entry name" value="L-ascorbate oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000061">
        <property type="entry name" value="Laccase TilA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF488">
        <property type="entry name" value="LACCASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0186">Copper</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010208617" evidence="7">
        <location>
            <begin position="26"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="10">
        <location>
            <begin position="41"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="8">
        <location>
            <begin position="294"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="9">
        <location>
            <begin position="473"/>
            <end position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CBF88560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="601" mass="66330" checksum="C46862ABEB03581E" modified="2005-04-26" version="1">MGFLRRRSMMQALLLTIIFSAYAYGANVKTTGQMVSFQVNLTWSDYQPAGIPRKMILANGQFPAPALRLKQGDDVEFLVNNEMPFSTTVHFHGIEQQGTPWSDGVPGLSQRPIPPGESFLYKWRATNYGSYFYHAHSRGQQEDGLYGAIHILADDSIERPFALISEDEQEIQSMRRAESESIPIMLSDVRSLTSAEIWDAEKAMGRDALCANALLVNGKGSVTCLGQQTIDEYTSVAQRGVLGNQSLTDIGCLPPDNLLAQGPWSHNLSAIPPTVFSDCIPSHGLTERFYPDATNRYASFDLVSAALVSTITFSIDEHPMYVYAIDGSYINPIEADGITITNGARYSVLVKLDKPRGDYTIRVVNTGLNQILHGNALMTYHNGIGPIQQHPSTPSIDLVGTPTSNHTLLNESMIIPFAAQDVSRVDVAQTLTLTLERYNASYTWTMGDSSFPLQLEEESPLLFYPQTASKNFTATSKNGTWVDVVFDVANAIQPPHPIHKHSNKFYVLGGGNGKWNYTSVAEAAKHMPESFNFETPQIRDTFATLPAATGPTWLALRYHVVNPGPFLLHCHIQIHQSGGMALALLDGIDEWPEIPEEYQLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="112" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BF63</accession>
    <accession>C8VQF8</accession>
    <name>Q5BF63_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">C2H2 transcription factor (Sfp1), putative (AFU_orthologue AFUA_1G14750)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ANIA_00817</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF88725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_658421.1">
        <property type="nucleotide sequence ID" value="XM_653329.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BF63"/>
    <dbReference type="FunCoup" id="Q5BF63">
        <property type="interactions" value="1810"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5BF63"/>
    <dbReference type="GeneID" id="2876597"/>
    <dbReference type="KEGG" id="ani:ANIA_00817"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN0817"/>
    <dbReference type="eggNOG" id="KOG4124">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013026_2_1_1"/>
    <dbReference type="InParanoid" id="Q5BF63"/>
    <dbReference type="OMA" id="STVQDMD"/>
    <dbReference type="OrthoDB" id="3269380at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000676">
        <property type="entry name" value="C2H2 transcription factor (Sfp1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051580">
        <property type="entry name" value="ZnF-Chromatin_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23057">
        <property type="entry name" value="JUXTAPOSED WITH ANOTHER ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23057:SF0">
        <property type="entry name" value="JUXTAPOSED WITH ANOTHER ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="440"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="501"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="61"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="245"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="247"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="273"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="300"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBF88725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="566" mass="61029" checksum="8C0F4EAE73890AF7" modified="2005-04-26" version="1">MNTTTPIDIATRQTSVSPPGQQASNLTSALQKAGNTERTGSISHANGVPISMFKASAPRKDSIGAASTQWGNGTKPISMSGSNRNQQRRESLAGSLVGGMSWGGVSVGSWIRDDIIMAGTSPFTTFQSPSFHSSSYLPKLEANFMRDFSCCGVTLPTLHDLLQHYEEAHATKSGHRPSQTDNRAALAAAAIAQQNQQNNNQNRGLQPDRTFDMQRKMNQSHTPQQHSDMDTIDDMELDDAMDDTDASSQFFTPQSRDPTQGGFGTPNRGVPNLNLSMLPSHQGFKSSQPGTPVATGLPLSLQNNPTVSSVNTPTLMPNPLQNSQFRGTPDSSTPGTPAELDDSMIGPFGELSMQNAMMQGQPQFSRFTGNNDMVDLCIDEPAKRLFSPTGGINQSNAHFKLSGAQYGPNSDIARRIREQQLLAGVPDTTSILPNEEPKPYRCPVIGCEKAYKNQNGLKYHKAHGHNNQQLHDNADGTFSIVNPETSAPYPGTLGMEKEKPYRCEVCGKRYKNLNGLKYHKSHSPPCNPDFQLAAARSLNYGGGVMQGQNINVAGAGLPGIGEEGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="149" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BFA9</accession>
    <accession>C8VQW1</accession>
    <name>Q5BFA9_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">ANIA_00771</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF88817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_658375.1">
        <property type="nucleotide sequence ID" value="XM_653283.2"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q5BFA9">
        <property type="interactions" value="367"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5BFA9"/>
    <dbReference type="GeneID" id="2876549"/>
    <dbReference type="KEGG" id="ani:ANIA_00771"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN0771"/>
    <dbReference type="eggNOG" id="KOG0065">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_35_0_1"/>
    <dbReference type="InParanoid" id="Q5BFA9"/>
    <dbReference type="OMA" id="EMNGIYM"/>
    <dbReference type="OrthoDB" id="245989at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03233">
        <property type="entry name" value="ABCG_PDR_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03232">
        <property type="entry name" value="ABCG_PDR_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000881">
        <property type="entry name" value="ABC multidrug transporter A-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000054">
        <property type="entry name" value="ABC multidrug transporter atrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029481">
        <property type="entry name" value="ABC_trans_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034001">
        <property type="entry name" value="ABCG_PDR_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034003">
        <property type="entry name" value="ABCG_PDR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010929">
        <property type="entry name" value="PDR_CDR_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14510">
        <property type="entry name" value="ABC_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06422">
        <property type="entry name" value="PDR_CDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="539"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="571"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="646"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="679"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="782"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1197"/>
            <end position="1218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1230"/>
            <end position="1253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1274"/>
            <end position="1300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1320"/>
            <end position="1342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1354"/>
            <end position="1378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1473"/>
            <end position="1491"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="172"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="859"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="826"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="36"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CBF88817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="1499" mass="167972" checksum="AA822534CA902339" modified="2005-04-26" version="1">MSSFLGTGTFNTSVSPSQAVESRGIENHGNAITETETLHNESHAESPGEKLASSSNSILSSTETAREKDERDYELDAEEEVTRLAQQLTHQSTKYSTHNIENPFLEVGEDSTLNPHSPNFKAKNWMKNLLALSSRDPERYLPRQAGVSFTNLSVHGYGSPTDYQKDVFNSVLQIGGLVRSMMGHGKQKIEILRNFDGLVKAGEMLVVLGRPGSGCSTFLKTIAGEMNGIFMDEKSQLNYQGIPAKQMRKQFRGEAIYTAETDVHFPQLSVGDTLKFAALARCPRNRLPGVSREQYAVHMRDVVMAMLGLSHTINTRVGNDFVRGVSGGERKRVSIAEATLSASPLQCWDNSTRGLDSANALEFCRTLNLMAKYSGATMAVAIYQASQSAYDVFDKVTVLYEGRQIYFGRTDDAKQFFIDMGFECPERQTTADFLTSLTSPAERIVRKGYEGRVPQTPDEFAAAWKNSDAYAQLMREIEEYNQEFPLGGESVNKFIESRRAMQSKNQRVKSPYTMSVMEQVNLCMIRGFQRLKGDASLTLSQLIGNFIMALVIGSVFYDLDNDTGSFYSRGALLFFAVLLNAFGSALEILTLYAQRPIVEKQARYAMYHPFAEAIASMLCDMPYKITNTFTFNIPLYFMTNLRREPGAFFIFLLFSFVTTLTMSMLFRTMAATSRTLSQALVPAAILILGLVIYTGFTIPTRNMLGWSRWMNYIDPIAYGFESLMVNEFHGRLFPCSESELVPSYGDTANRVCAVVGATPGELMVNGTTYLRESYQYTKSHEWRNLGIMFAFMAFFLFTYLTATEYISEAKSKGEVLLFRRGQAPPSVNDVETHSPATAGEKVDQSTQDVANIQRQTAIFHWKDVCYDIKIKNEPRRILDHVDGWVKPGTCTALMGVSGAGKTTLLDVLATRVTMGVVTGEMLVDGRPRDQSFQRKTGYVQQQDLHLHTTTVREALRFSALLRQPAKTPRQEKLDYVEEVIKLLGMEAYADAVVGVPGEGLNVEQRKRLTIGVELAAKPQLLLFLDEPTSGLDSQTSWSILDLIDTLTQHGQAILCTIHQPSAMLFQRFDRLLFLAKGGKTVYFGEIGEKSSTLASYFERNGAPKLPADANPAEWMLEVIGAAPGSHSDIDWPAVWRESPERQAVHQHLAELKETLSQKPTETSASDPSEYNEFAAPFSVQLWECLVRVFSQYWRSPVYIYSKAALSILTSLYIGFSFFQAQNTRQGLQNQMFSIFMLMTIFGNLVQQIMPNFVTQRALYEVRERPSKAYSWKAFMTANILVELPWNTLMAVIMYFCWYYPVGLYRNAEPTDSVHERGALMFLLILAFLLFTSTFAHMIIAGIETAETGGNIAQLLFSLCLIFCGVLAGPDVLPGFWIFMYRVSPFTYLVSAMLSTGVSGTTAYCEQVEYLTLYPPSNTTCSEYMDPYISQVGGYLQNPDATSECTFCQISSTDTFLSAVYSNYDDAWRNFGLMWAYIAFNIAAAVFIYWLARVPKGKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BFM0</accession>
    <accession>C8VRZ2</accession>
    <name>Q5BFM0_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uracil transporter (Eurofung)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ANIA_00660</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF89038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_658264.1">
        <property type="nucleotide sequence ID" value="XM_653172.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BFM0"/>
    <dbReference type="FunCoup" id="Q5BFM0">
        <property type="interactions" value="587"/>
    </dbReference>
    <dbReference type="GeneID" id="2876438"/>
    <dbReference type="KEGG" id="ani:ANIA_00660"/>
    <dbReference type="eggNOG" id="KOG2466">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021555_2_0_1"/>
    <dbReference type="InParanoid" id="Q5BFM0"/>
    <dbReference type="OMA" id="GWNWRAV"/>
    <dbReference type="OrthoDB" id="2018619at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015851">
        <property type="term" value="P:nucleobase transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.4160.10:FF:000028">
        <property type="entry name" value="Uracil transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045225">
        <property type="entry name" value="Uracil/uridine/allantoin_perm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618:SF2">
        <property type="entry name" value="ALLANTOIN PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618">
        <property type="entry name" value="NCS1 FAMILY PURINE/PYRIMIDINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="47"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="199"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="249"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="290"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="320"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="360"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="397"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="448"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBF89038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="478" mass="52825" checksum="2C78F60E6B720D7A" modified="2005-04-26" version="1">MSAIKRWIKKLEVESDPGLTNTQLMLTNHDLRPVEPDRRQWRWYNFIFFWIADSLNIGYIGGQCITLMIRAIWPSYESLPNGIPESSGVDTKNFLSFFLFWLLSLPALWFPVHQIRHLFTVKSIYSPIAAIAFFAWAISRANGLGPIVHQSHTVHGSTLAWAVVKALMSCLGNFAALIMNDPDFSRFARKPKDALWAQLLTIPIGFGITSFIGIIASSSSAVIFGGDAIWNPLDLLGRFLEGASSAERFGVFIIALGFALAQLGTNISANSVSAGTDMTALLPRYITIRRGSYICAAIGLAMCPWNLVSDSNQFTTYLSAYSIFLSAIAGVMICDYYVVRKGYLIVKDLYSGEKDSAYRFNYGFSWQAYASYLSGLLINIVGFAGAVGRDVPVGAQYIYNVNYLSGFIVSFVMYFIITRLCPIAATSDTWNEVNTDLELDTEGHDIDAEDIHTGKPIGFETSEPREDYKGAKAGSASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="153" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BFV4</accession>
    <accession>C8VSD3</accession>
    <name>Q5BFV4_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">ANIA_00576</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="16">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF89201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_658180.1">
        <property type="nucleotide sequence ID" value="XM_653088.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q5BFV4">
        <property type="interactions" value="796"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5BFV4"/>
    <dbReference type="GeneID" id="2876351"/>
    <dbReference type="KEGG" id="ani:ANIA_00576"/>
    <dbReference type="eggNOG" id="KOG1240">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001696_0_1_1"/>
    <dbReference type="InParanoid" id="Q5BFV4"/>
    <dbReference type="OMA" id="ATNTCRI"/>
    <dbReference type="OrthoDB" id="242910at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071561">
        <property type="term" value="C:nucleus-vacuole junction"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034271">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type I"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034272">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type II"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045324">
        <property type="term" value="P:late endosome to vacuole transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000425">
        <property type="term" value="P:pexophagy"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd13980">
        <property type="entry name" value="STKc_Vps15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000497">
        <property type="entry name" value="Phosphoinositide 3-kinase regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000652">
        <property type="entry name" value="Related to VPS15-ser/thr protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000342">
        <property type="entry name" value="Serine/threonine-protein kinase VPS15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055231">
        <property type="entry name" value="2AA_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045162">
        <property type="entry name" value="Vps15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17583">
        <property type="entry name" value="PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17583:SF0">
        <property type="entry name" value="PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22956">
        <property type="entry name" value="VPS15-like_hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 12" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="25"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="11">
        <location>
            <begin position="433"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="1133"/>
            <end position="1174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="870"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="909"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1533"/>
            <end position="1553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="950"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="975"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="988"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="1536"/>
            <end position="1551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CBF89201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="1599" mass="177919" checksum="691363CADDCAF887" modified="2005-04-26" version="1">MGQGYSLTTLSAGSAGIDIPELSDLTYEKSMGGGRFMKSIRARQKNGLVFVKVIMKPYPSMKLEPYVRAIIRERKLLSDIPNALAYQRILETSTGGYLVRQYIHSSLYDRMSTRPFPEDIEKKWIAFQLLCALRDCHAVDVFHGDIKTENVLVTAWNWVYLSDFSSSFKPTFLPEDNPADFSFYFDTSGRRTCYLAPERFLVANEEPGSRNVNWAMDIFSAGCVIAELFLESPIFTLSQIYKYRKGEYSPEHSQLAKIEDPEIRALILHMIQLDPESRYSAEEYLNFWKIKAFPEYFYSFLHQYMSLMTDPSSGRTQVEAGSANRGEADDRIERVYLDFDKISSLLGAHLEPGKDGSLSTTSKLTSGTFPVELDLPRYKYSDRTSTDDGVLIFLTLVVSSLRSTSKSSARIKACDILLAFAERLSDEAKLDRILPYIMILLNDRTDSVKIAAIRSLARLLEMVQVVSPVNAYLFSEYIFPRLQPFVPNANSQPSPAVRAAYASCIASLAHSSLRFLDMIQALRSDTRLPALIPAGSEPRWTEDSTYHNLYDVARIDLLDYFETHTKALLTDTDASVRRAFLGSVSSLCVFFGTIKTNEVILSHLNTYLNDRDWILKCAFFEAVVGVAVYVGTTSLEQYILPLMVQSMTDPEEFVVERVLRSLAAMADLGLFQRPTTWDLLHATVRFLVHPNAWIREAAVSLVVNSTKFLSTADKYSILTPLVRPFLKVSIVDFSEGDILDALKTPLPKALYDQAFVWASQAEKGFFWKSVGRDGASLGSVDAAFQKRASKAFSLSAQPKNDEDEQWIAKLRALGLTTEDESKLLALREHIWRVSMRQTKDHESAGASLNNVVALIDYGVTPQTVFFDKSQNVKARRNHENPVGRPQLTRAEDSKAHTIADALLDASTTIDNNANSRRRHARTKSQAQQEIEAAISTPRPNNIEVLRAEDSPASSPIASSPSAAPGSRPMSPPSSDAERKLPEGRRSPGQESSSTETDNLSLRRLKAGVQKKSSAISLLNRRDTAKAYAETGTSSANVFGKIGVPAQRDAISPAPRERKPVDLQTHQYRANHSYAGNDPMILRLLDSVFAENYPTDFFDLGPYVKELDTRRPIMKADGDVSKVWKPTGTLVTLFGEHSGPVNRVVVAPDHSFFITGSDDGTVKVWDTTRLEKNLTPRSRQTYRHSSDAKVRALTFVENTHTFVSGATDGSIHAVKVGYHNSNGTVRYGKLQLVREYQLSTTDDASPEYAVWMEHFRTDAQSTLLIATSMCRIIALDMKSMRPVYTLQNPTHHGTPTSFCCDRKHNWLLVGTTHGILDLWDLRFQVRLKAWGLSGSGPIHRLQLHPTKGHGRWVCVSASGNHGNEIIVWDIEKTKCREVYRADSPALGHNHPNQAKGISDKEIARRSPPNLKDYEAWHVEGDRPEGMLSRFGTGTVEPPSGSPSTGTSSGTGINTFIGGFDCPEDGRDNSTRVGFIISGGCDRKIRFWDLHRPDQSCIISGLDPISDGTVTGSPRYEVSSPTQSLTFAIEHLPNPGANAGGAKGSGKRSGGGRLPRSTVISLQQQQLLKSHLDFIQDIAVLRVPYGMIISVDRAGMVYVFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BG16</accession>
    <accession>C8VSW1</accession>
    <name>Q5BG16_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_00514</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF89331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_658118.1">
        <property type="nucleotide sequence ID" value="XM_653026.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BG16"/>
    <dbReference type="GeneID" id="2876291"/>
    <dbReference type="KEGG" id="ani:ANIA_00514"/>
    <dbReference type="HOGENOM" id="CLU_1170629_0_0_1"/>
    <dbReference type="InParanoid" id="Q5BG16"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="210"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF89331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="237" mass="27268" checksum="920DCAD7616B65EE" modified="2005-04-26" version="1">MLTQELQRLGRELSSLDRISEGEEGSELEGTTQINQLNIVLSFVTMAQKPLTVTQLEAILEIIFREEVLNLEDDLCLPEMEADDRLPLVILQLLIFYNNMLAYYTSENINSRENTPMDMQLYHSQVYKIFAAAEIYKFQQTLLWHVRVAQALLLNGHLQEAQGQFQIALEEHKSAPTFDQLLLFIIYRDMARACSDIRRHGEALEHHELSEQLESLLAQLQHNARRTADAVKTANEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="111" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BGT3</accession>
    <accession>C8VUK7</accession>
    <name>Q5BGT3_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RNA cytidine acetyltransferase</fullName>
            <ecNumber evidence="9">2.3.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">18S rRNA cytosine acetyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">NAT10</name>
        <name evidence="15" type="ORF">ANIA_00247</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="16">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA-binding adapter protein TAN1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a cytidine in 18S rRNA + acetyl-CoA + ATP + H2O = an N(4)-acetylcytidine in 18S rRNA + ADP + phosphate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51424"/>
            <dbReference type="Rhea" id="RHEA-COMP:13575"/>
            <dbReference type="Rhea" id="RHEA-COMP:13576"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:74900"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a cytidine in tRNA + acetyl-CoA + ATP + H2O = an N(4)-acetylcytidine in tRNA + ADP + phosphate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53876"/>
            <dbReference type="Rhea" id="RHEA-COMP:13670"/>
            <dbReference type="Rhea" id="RHEA-COMP:13671"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:74900"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Interacts with TAN1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
            <location evidence="1 9">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the RNA cytidine acetyltransferase family. NAT10 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="9"/>
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    <sequence length="1076" mass="120097" checksum="7285AB61FD037E0B" modified="2005-04-26" version="1">MPRKAIDSRIPALIQNSIQEKKRNFFVVVGDRAKDIIVNLYHIRSQFDVKQNKSVLWAYKKDLLGFTSHRKKREAKIKREVKRGIREPNEEDPFELFVTLNQIRYVYYKETEKILGNTYGMCILQDFEAITPNLLARTIETVEGGGTVIMLLKSMNSLKQLYTLSMDIHSRYRTEAHDDVVARFNERFILSLGSCDSCLVIDDEMNVLPISGGKNVKPLPPPDETDGTSKGTKKELEKIKDDLAESQPVGSLVNLARTVDQAKALLTFVDAIAEKTLRSTVTLTAARGRGKSAALGVAIAAAIAYGYSNIFITSPSPENLKTLFEFIFKGFDALGYADHADYTILQSTNPDFNKAIVRVNIHRQHRQTIQYIQPQDAHVLGQAELLVIDEAAAIPLPLVRKLMGPYLVFMASTINGYEGTGRSLSLKLIQQLREQSRGGAKIAGDDTDVASRATGKIEKNSDKGLGGRSLREITLSEPIRYAPGDSVEKWLNRVLCLDATLPKSKMNTQGCPHPSQCQLLQVNRDTLFSFHPVSEKFLQQMMALYVASHYKNTPNDLQLMSDAPAHQLFVLVPPIDEDAAKLPEPLCVIQVALEGRISRQSVLNSLSRGQRAGGDLIPWLVSQQFQDEDFASLSGARIVRIATNPEYLSMGYGSRALELLVDFFEGKFTDLSENIVDTQEEMVRVTDEELANSNLLDDNIQVRDIRSMPPLFGKLSERRPDQLDYLGVSYGLTPALHKFWKRASFTPVYLRQTPNDLTGEHSCVMLRTLSTGSNDISWLGAFARDFHRRFISLLSYQFRTFASVLSLSIGESATAGAKLDPSLAPSPLTKSDLDAAFSPFDLKRLDSYANNLLDYHVILDMVPIIATWYFSGRLAGKVNLSGVQQSILLAIGLQRKSLDDVEKELSLPSSQLLAMFLKIVRKVSTHFRSLEESAVADTLPAENVPATSAAADAHDEVVDERFKPLETSLDDELREGGEEINAEMREKQRALIDALPLDKYEISNGDAGWEEAEKQIRSGGAATVSVKSSKQNKRKKGETAREIYEQEIESKRQKIIQKGTEGKKKKRLIGYIQKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="116" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BH13</accession>
    <accession>C8VQ43</accession>
    <name>Q5BH13_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation initiation factor eIF2B subunit alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eIF2B GDP-GTP exchange factor subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ANIA_00167</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the eIF-2B alpha/beta/delta subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF90056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_657771.1">
        <property type="nucleotide sequence ID" value="XM_652679.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BH13"/>
    <dbReference type="FunCoup" id="Q5BH13">
        <property type="interactions" value="1147"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5BH13"/>
    <dbReference type="GeneID" id="2875943"/>
    <dbReference type="KEGG" id="ani:ANIA_00167"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN0167"/>
    <dbReference type="eggNOG" id="KOG1466">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016218_0_1_1"/>
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        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
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        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
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        <property type="term" value="P:negative regulation of TORC1 signaling"/>
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        <property type="term" value="P:positive regulation of cellular response to amino acid starvation"/>
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        <property type="entry name" value="Translation initiation factor eIF-2B, N-terminal domain"/>
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        <property type="entry name" value="eIF2B_alpha/beta/delta"/>
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        <property type="entry name" value="elF-2B_alpha_N"/>
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        <property type="entry name" value="IF-2B-related"/>
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        <property type="entry name" value="IF_2B-like_C"/>
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        <property type="entry name" value="NagB/RpiA_transferase-like"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 10" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00044208"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00044236"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBF90056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="352" mass="37788" checksum="471CDF882C162665" modified="2005-04-26" version="1">MTATDSQITKPSEPFDIVATYNDLLRSDPDLTMPIAAIEALVLLLTHSPSSTISETLDLLEKSTTHLKKSIPNPIGLSAGTDLFQRYLITTLQRPGQLGPAGDFNAIRAHLLSNSRLFIRRAKESRDKIAGFGRGFVRDGSTVLTNGGSRVVASLLQQAADEKGGPSAVRFNVIYVLSSPKGDIENPTAEPEGMETVRALRAKGVPVATIPESAVAYSLGKADVVIVGAEGVVENGGIVSRMGTYQIGLLAKAMGKPFYVVAESHKFVRVYPLGQYDLPIEQHVIDFKTQEEVDNAKQQREPADASKSSGLNTEFDAGSVDFTPPHLISALITDSGVLTPSAVSEELIKIWF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-09-13" modified="2025-06-18" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BH69</accession>
    <accession>C8VQL5</accession>
    <name>SYF1_EMENI</name>
    <protein>
        <recommendedName>
            <fullName>Pre-mRNA-splicing factor syf1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">syf1</name>
        <name type="ORF">AN0111</name>
    </gene>
    <organism>
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in pre-mRNA splicing and cell cycle progression.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the crooked-neck family.</text>
    </comment>
    <dbReference type="EMBL" id="AACD01000004">
        <property type="protein sequence ID" value="EAA65289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF90179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_657715.1">
        <property type="nucleotide sequence ID" value="XM_652623.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BH69"/>
    <dbReference type="SMR" id="Q5BH69"/>
    <dbReference type="FunCoup" id="Q5BH69">
        <property type="interactions" value="1022"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5BH69"/>
    <dbReference type="EnsemblFungi" id="CBF90179">
        <property type="protein sequence ID" value="CBF90179"/>
        <property type="gene ID" value="ANIA_00111"/>
    </dbReference>
    <dbReference type="KEGG" id="ani:ANIA_00111"/>
    <dbReference type="eggNOG" id="KOG2047">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007736_0_0_1"/>
    <dbReference type="InParanoid" id="Q5BH69"/>
    <dbReference type="OMA" id="IWYNYLR"/>
    <dbReference type="OrthoDB" id="10067343at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000349">
        <property type="term" value="P:generation of catalytic spliceosome for first transesterification step"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000666">
        <property type="entry name" value="DNA repair and transcription protein (Xab2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000023">
        <property type="entry name" value="Pre-mRNA-splicing factor SYF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000038">
        <property type="entry name" value="Putative pre-mRNA-splicing factor SYF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055433">
        <property type="entry name" value="HAT_Syf1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056350">
        <property type="entry name" value="HAT_Syf1_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055430">
        <property type="entry name" value="HAT_Syf1_CNRKL1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045075">
        <property type="entry name" value="Syf1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246:SF5">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR SYF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23231">
        <property type="entry name" value="HAT_Syf1_CNRKL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23233">
        <property type="entry name" value="HAT_Syf1_CNRKL1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23220">
        <property type="entry name" value="HAT_Syf1_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0507">mRNA processing</keyword>
    <keyword id="KW-0508">mRNA splicing</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0747">Spliceosome</keyword>
    <feature type="chain" id="PRO_0000205730" description="Pre-mRNA-splicing factor syf1">
        <location>
            <begin position="1"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="repeat" description="HAT 1">
        <location>
            <begin position="12"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="repeat" description="HAT 2">
        <location>
            <begin position="63"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="repeat" description="HAT 3">
        <location>
            <begin position="107"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="repeat" description="HAT 4">
        <location>
            <begin position="141"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="repeat" description="HAT 5">
        <location>
            <begin position="291"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="repeat" description="HAT 6">
        <location>
            <begin position="398"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="repeat" description="HAT 7">
        <location>
            <begin position="434"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="repeat" description="HAT 8">
        <location>
            <begin position="487"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="repeat" description="HAT 9">
        <location>
            <begin position="558"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="repeat" description="HAT 10">
        <location>
            <begin position="595"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="repeat" description="HAT 11">
        <location>
            <begin position="667"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="repeat" description="HAT 12">
        <location>
            <begin position="703"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="771"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="810"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="825"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="842"/>
            <end position="851"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="851" mass="98616" checksum="A1DECCE9303646EF" modified="2005-04-26" version="1">MDRSSASRPDLYLIADNDSVYEQDLLRNPGTIKPWLAYIEYKQQNGTLYEQAFVGRPLDALIISILNDFQVMERACKQLPRSYKLWKMYLEFRTKHLKNRNAIKYRAEFQKVNTLFERALILLNKMPRIWEMYLTFMLQQPLVTQTRRTFDRALRALPVTQHNRIWKLYKTFARSASGQTAVKIWARYMQIHPENAEEYINLLVEMGHYTDAIKRYMEILDNPRFQSREGKSNFQLWTEMVDLLVSKAKKIETGPQTGIDVDAILRSGIDRFADQRGKLWAGLATYWITKGNFEKARDVFEEGITTVMTVRDFTLIFDSYVEFEESIIGSLMEAAAVRADNGKADEEADFDLDLRMLRFEQLMDRRPFLVNDVLLRQNPNNVIEWEKRVALWGDNNVEIVNTYTAAIAAINPKKAVGKFSELWVNYAKFYERGGDLDTARIIFEKAVKVPFKSVNELAETWCEWAEMELRSENFDKAVEIMAKATQAPKKSTVDYFDETLSPQQRIHKSWKLWSFYVDLVESVSSIEETKKVYERIFELRIATPQTVVNYANLLEEHKYFEESFKVYERGLDLFTYPVAFELWNLYLTKAVDRKIGIERLRDLFEQALDGCPPKFARPLYLMYGNLEEERGLARHAMRIYERATRAVSDEDRFEMFEFYITKSASNFGLPSTRPIYERAIAALPDHEAKEMCLKFAEMERRLGEIDRARAIYGHASQFCDPRTNAPFWQKWEAFEVQHGNEDTFKEMLRIKRSVQAQYNTDVNFIASQAIARSQQRAPEGEEATAAAEREMDTETTDAMAALERQARAPIGFVAASTGPEGGNRAPPAGQGPVAAPANPDAIDLDDDMEAD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-09-19" modified="2026-01-28" version="119" xmlns="https://uniprot.org/uniprot">
    <accession>Q9UV64</accession>
    <accession>C8VNI3</accession>
    <accession>Q5BCU3</accession>
    <name>MOCOS_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Molybdenum cofactor sulfurase</fullName>
            <shortName evidence="1">MCS</shortName>
            <shortName evidence="1">MOS</shortName>
            <shortName evidence="1">MoCo sulfurase</shortName>
            <ecNumber evidence="1">2.8.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Molybdenum cofactor sulfurtransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">hxB</name>
        <name type="ORF">AN1637</name>
    </gene>
    <organism>
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Mol. Microbiol." volume="38" first="114" last="125">
            <title>Comparison of the sequences of the Aspergillus nidulans hxB and Drosophila melanogaster ma-l genes with nifS from Azotobacter vinelandii suggests a mechanism for the insertion of the terminal sulphur atom in the molybdopterin cofactor.</title>
            <authorList>
                <person name="Amrani L."/>
                <person name="Primus J."/>
                <person name="Glatigny A."/>
                <person name="Arcangeli L."/>
                <person name="Scazzocchio C."/>
                <person name="Finnerty V."/>
            </authorList>
            <dbReference type="PubMed" id="11029694"/>
            <dbReference type="DOI" id="10.1046/j.1365-2958.2000.02119.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <scope>FUNCTION</scope>
        <scope>PATHWAY</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="1999" name="Mol. Microbiol." volume="31" first="1065" last="1073">
            <title>The hxB gene, necessary for the post-translational activation of purine hydroxylases in Aspergillus nidulans, is independently controlled by the purine utilization and the nicotinate utilization transcriptional activating systems.</title>
            <authorList>
                <person name="Amrani L."/>
                <person name="Cecchetto G."/>
                <person name="Scazzocchio C."/>
                <person name="Glatigny A."/>
            </authorList>
            <dbReference type="PubMed" id="10096075"/>
            <dbReference type="DOI" id="10.1046/j.1365-2958.1999.01242.x"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="1 4">Sulfurates the molybdenum cofactor. Sulfation of molybdenum is essential for xanthine dehydrogenase (XDH) and aldehyde oxidase (ADO) enzymes in which molybdenum cofactor is liganded by 1 oxygen and 1 sulfur atom in active form.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O</text>
            <dbReference type="Rhea" id="RHEA:42636"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
            <dbReference type="ChEBI" id="CHEBI:82685"/>
            <dbReference type="EC" id="2.8.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="induction">
        <text evidence="3">By the nicotinate utilization transcriptional activating systems.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. MOCOS subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.9" evidence="1"/>
    <dbReference type="EMBL" id="AF128114">
        <property type="protein sequence ID" value="AAF22564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AACD01000026">
        <property type="protein sequence ID" value="EAA64757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF85269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_659241.1">
        <property type="nucleotide sequence ID" value="XM_654149.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9UV64"/>
    <dbReference type="SMR" id="Q9UV64"/>
    <dbReference type="STRING" id="227321.Q9UV64"/>
    <dbReference type="EnsemblFungi" id="CBF85269">
        <property type="protein sequence ID" value="CBF85269"/>
        <property type="gene ID" value="ANIA_01637"/>
    </dbReference>
    <dbReference type="GeneID" id="2875359"/>
    <dbReference type="KEGG" id="ani:ANIA_01637"/>
    <dbReference type="eggNOG" id="KOG2142">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010913_0_0_1"/>
    <dbReference type="InParanoid" id="Q9UV64"/>
    <dbReference type="OMA" id="PCTRCQM"/>
    <dbReference type="OrthoDB" id="10264306at2759"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008265">
        <property type="term" value="F:molybdenum cofactor sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043545">
        <property type="term" value="P:molybdopterin cofactor metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03050">
        <property type="entry name" value="MOCOS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005302">
        <property type="entry name" value="MoCF_Sase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028886">
        <property type="entry name" value="MoCo_sulfurase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005303">
        <property type="entry name" value="MOCOS_middle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14237:SF80">
        <property type="entry name" value="MOLYBDENUM COFACTOR SULFURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14237">
        <property type="entry name" value="MOLYBDOPTERIN COFACTOR SULFURASE MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03473">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03476">
        <property type="entry name" value="MOSC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141673">
        <property type="entry name" value="MOSC N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51340">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000249963" description="Molybdenum cofactor sulfurase">
        <location>
            <begin position="1"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="domain" description="MOSC" evidence="1">
        <location>
            <begin position="656"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="651"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="651"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="401"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="1">
        <location>
            <position position="237"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; AAF22564." evidence="5" ref="1">
        <original>VDDIR</original>
        <variation>AGRYS</variation>
        <location>
            <begin position="78"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; AAF22564." evidence="5" ref="1">
        <original>T</original>
        <variation>S</variation>
        <location>
            <position position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="10096075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="11029694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <sequence length="839" mass="92527" checksum="0D3C8DFAE34CA1B6" modified="2006-09-19" version="2">MNLSKGTAAAYCSGYSEDVDVIREREYPLLKDTTYLDHAGTTLYANSLIHSFGRDLTGNLYGNPHSMSASSQLSAQRVDDIRLRALRFFNADPDEFDLVFVANATAGIKLVADALQNSPQGFWYGYYVDAHTSLVGVRELAKMGSRCFVNEDEVDSWISGLGSRREESLGLFAYPAQSNMNGRRVPMRWCEQIRAQKENADNMIYTLLDAASFVSTSPLDLSKIAAAPDFTVLSFYKIFGFPDLGALIVRKSSGDVFKHRKFFGGGTVDMVLTDGNPWHAKKQSSIHQSLEDGTLPFHSIIALDSAFETHGRLFRSMENVASHTRFLAKRLRDRMNALKHYNGTKVCQLYMSPNSSYDDASSQGPILAFNLRNSRGMWIGKSEVERLASIKNIQIRSGTLCNPGGTALSLGWTGADMLRHFSAGMRCGDDHDIMDERPTGILRISLGAMSSLTDVDTFIAFLEEFYVDKPPEGLPVPLTGNVSLHQPSFYVESLSVYPIKSCGAFRIPDGQRWEVRREGLAWDREWCLVHQGTGITLNQKRYPRMALIRPTLDLERCLLRITCGEANSRDGKTLEISLNRIGTNSLTTSLCQNASKPSTVCGDKVVLQAYTSPAVSRFFTDFLGVPCTLARFPPQSSTRFHSRATAAINRDQNYSQKQSPSMPGSFPQAPSSPDPYPTPILLSNESPLLLISRSSVNRLNESIKSASQPCSNPGSAASKKAVAADVFRANVVVAENISTAERPYIEDTWASLSIGSGPEQLRFDVLGSCERCQMVCVDQYTGQRGDEPYATLAKTRKIDRKILFGRHISPVGRPKDAENGCLGTIMVGDAVTPSYDNES</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C8UZY9</accession>
    <name>C8UZY9_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein ARV</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">ANIA_05868</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Mediator of sterol homeostasis involved in sterol uptake, trafficking and distribution into membranes.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Regulates also the sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Golgi apparatus membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ARV1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF70675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467070.1">
        <property type="nucleotide sequence ID" value="XM_050612648.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8UZY9"/>
    <dbReference type="STRING" id="227321.C8UZY9"/>
    <dbReference type="GeneID" id="2871111"/>
    <dbReference type="KEGG" id="ani:ANIA_05868"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN5868"/>
    <dbReference type="eggNOG" id="KOG3134">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057366_0_0_1"/>
    <dbReference type="InParanoid" id="C8UZY9"/>
    <dbReference type="OMA" id="WAVERCF"/>
    <dbReference type="OrthoDB" id="2192830at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032366">
        <property type="term" value="P:intracellular sterol transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097036">
        <property type="term" value="P:regulation of plasma membrane sterol distribution"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006665">
        <property type="term" value="P:sphingolipid metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016125">
        <property type="term" value="P:sterol metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007290">
        <property type="entry name" value="Arv1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14467">
        <property type="entry name" value="ARV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14467:SF0">
        <property type="entry name" value="PROTEIN ARV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04161">
        <property type="entry name" value="Arv1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 10" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="365"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="153"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="295"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="155"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="170"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="186"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="247"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="295"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU368065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CBF70675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="411" mass="44335" checksum="AD06C01C1C093588" modified="2009-11-03" version="1">MPICIECSYPVSHLYSAYSRADDRSLGKGVRLTQCPRCKRFADKYVEYDFVVIFIDLVLIKPQVYRHLLFNRLESDEHKFDRSIIRLGVLLLLFDVYLTWARIEKSPLIETTFLSRAPIIIQYLFFLTLNALATLAHHLTVRLLASFITFSSQSTPTKQPTATANAAATESQAPVPSNPTTPILPSFPQQLVQAQQASALSPPKSTPHSSVQELPGLENQRPRQPSPSSPRDSFCDLRPPLRRASTGPMQSFQQLSPPSQASPTAISTALFVSSCAKLFPILLVIWGPDGRISSSNSTPSSGYGASAVSTLQPNPAQRAEGGSDLVVAGSAGSGLAESSPSVSSSLLEGLSAADMHLVLLSNIEALYILLGCGYLRATALAVAGLLARWAVQKVILGVVGVDNLRLCGQSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>C8V132</accession>
    <name>C8V132_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ANIA_06596</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG1 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF71064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467127.1">
        <property type="nucleotide sequence ID" value="XM_050613163.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V132"/>
    <dbReference type="STRING" id="227321.C8V132"/>
    <dbReference type="GeneID" id="2870663"/>
    <dbReference type="KEGG" id="ani:ANIA_06596"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN6596"/>
    <dbReference type="eggNOG" id="ENOG502RN59">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008451_0_0_1"/>
    <dbReference type="InParanoid" id="C8V132"/>
    <dbReference type="OMA" id="PQSLKSW"/>
    <dbReference type="OrthoDB" id="46189at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033370">
        <property type="entry name" value="COG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31658">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31658:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08700">
        <property type="entry name" value="VPS51_Exo84_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="675"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="687"/>
            <end position="696"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBF71064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="778" mass="87553" checksum="331E73E9C45F7517" modified="2009-11-03" version="1">MASDGPDPQSLKTWEDAFQYSIPTVRRLEQELRRDVASNKEKLRALVGTRYRELVGTAETIVAMSRNMEEVDTTLGDIGRRCNPRLVGKKYTHLNRMENNKTTAQDATKRALGAQLALLHRCSVLISKMLRKRGSPLLIAKLLVISRLLHKCLSEQKSVPPFLETLRNQLASLRRGLRSRINKLLASAKSTIDEVIEALAAYCLSTSSSSDDAVAYYHKVRLDVIGNQLDNAKPSGENILAALRLYIQTLQFSKTLLSRRFTDVLGKLKSRSLFTDPDIRNIDELSLDVLGRWVATDIFNFTPWIKLNEQSKQDADRAIKKWSKGAFEEFVRRSQDSLKTWADFSQLIQLRKETLGLWLCSWSSTTTHSTLQVLEGIRTVFNSRLKDILLDKAKDLGTFGQAVASALSGWDGDHGKTQSLWDHELLSLDYTNGAAAFREAITDKLLGRDAEISSATKEYQMWLSTIRTLREAVDALREVRWPDILEEAADEDLDLDVTAILNEDDSQLLRNALEAAVRQSFDALQGSFADSHKNIGDSGRGEKAAFMLKLVRLVRRDLPHEFIPKDTEFFKDIIPGLQEILAAEVIADTRPLSFASSVNPQTMTPAGRLLWEGDPELPVQPSPATFKFMRRILESMGRHGHGLWDMSTVCVFQRALQKDVARRITAYLDDIDSPADWAKPEDEKETPVQNGNSRSVAPTEAQLHDIKLQLYFDTIFLNSAMVDKATQQSSLQEVAEKLRNSFGSDAGSISETMDQRAQEYWHRTRLLFGLLAADAAQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>C8V169</accession>
    <name>C8V169_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450, putative (Eurofung)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ANIA_06321</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF69707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050466940.1">
        <property type="nucleotide sequence ID" value="XM_050611298.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V169"/>
    <dbReference type="STRING" id="227321.C8V169"/>
    <dbReference type="GeneID" id="2870969"/>
    <dbReference type="KEGG" id="ani:ANIA_06321"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN6321"/>
    <dbReference type="eggNOG" id="KOG0157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_27_0_1"/>
    <dbReference type="InParanoid" id="C8V169"/>
    <dbReference type="OMA" id="GDLWMFQ"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047146">
        <property type="entry name" value="Cyt_P450_E_CYP52_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287:SF18">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE APDE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="123"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="264"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="127"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="353"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBF69707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="410" mass="46712" checksum="5868997E6C0ECEB3" modified="2009-11-03" version="1">MSAVLLGKRYVSTPDPENIKAVLATKFVDFDLGERNAAFRPLLETGVFTQDGREWERSRALLRPIFNRAQALPDLLLIEEHVQSRLYRIPRGYDIVNLQQLVRDLTLDSAFIHFLAGRPRSQEAGEETSTLNRSVTHSTRPGLISRSPAHENRGKLGRGCGNESESEGWYDLLSKVADTVSDGVQIRSQLLHVLLAARDTTARLLSSVFYMLARHPSVWRKLEREVLVEFGLATQGDGKCPLPTYTQLREMKYVRAVLNEGCTRPTFSPPPPPSSPYEHPVRNTTHIPPARRRRRRMPAYIRGQEGDRALFYRTMQRFTEIYGDDAEQFRPERWVPLRRGWGFLPFSGGPRICLGQQKALTEAVYVVVRMVQTFCDIEARDERPWREQMGLVLSSYYGVKVGLKSRNGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>C8V1I9</accession>
    <name>C8V1I9_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cytochrome c oxidase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ANIA_06255</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome c oxidase subunit 6B family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF69846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050466954.1">
        <property type="nucleotide sequence ID" value="XM_050611510.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V1I9"/>
    <dbReference type="FunCoup" id="C8V1I9">
        <property type="interactions" value="419"/>
    </dbReference>
    <dbReference type="STRING" id="227321.C8V1I9"/>
    <dbReference type="GeneID" id="2871039"/>
    <dbReference type="KEGG" id="ani:ANIA_06255"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN6255"/>
    <dbReference type="eggNOG" id="KOG3057">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_133964_2_0_1"/>
    <dbReference type="InParanoid" id="C8V1I9"/>
    <dbReference type="OMA" id="NEWIAKW"/>
    <dbReference type="OrthoDB" id="1107506at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00926">
        <property type="entry name" value="Cyt_c_Oxidase_VIb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.140:FF:000001">
        <property type="entry name" value="Cytochrome c oxidase subunit 6B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.140">
        <property type="entry name" value="Cytochrome c oxidase, subunit VIb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048280">
        <property type="entry name" value="COX6B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036549">
        <property type="entry name" value="CX6/COA6-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003213">
        <property type="entry name" value="Cyt_c_oxidase_su6B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46281:SF8">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 12, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46281">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02297">
        <property type="entry name" value="COX6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000278">
        <property type="entry name" value="Cyt_c_oxidase_6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47694">
        <property type="entry name" value="Cytochrome c oxidase subunit h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="29"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="39"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000278-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBF69846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="84" mass="10055" checksum="DFAF81D524BC8DE4" modified="2009-11-03" version="1">MSLLRPSPSSSLLVSYDARFPQQNQTKHCWQNYVDYHKCVNAKGEDFRPCRQFYLAFRSLCPKPWTDRWDEQREAGNFPARLDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C8V445</accession>
    <name>C8V445_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF924-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_03630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF75739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_661234.2">
        <property type="nucleotide sequence ID" value="XM_656142.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V445"/>
    <dbReference type="STRING" id="227321.C8V445"/>
    <dbReference type="GeneID" id="2873055"/>
    <dbReference type="KEGG" id="ani:ANIA_03630"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN3630"/>
    <dbReference type="eggNOG" id="ENOG502S80R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065010_0_1_1"/>
    <dbReference type="InParanoid" id="C8V445"/>
    <dbReference type="OMA" id="NWFYMPL"/>
    <dbReference type="OrthoDB" id="414698at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.320">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010323">
        <property type="entry name" value="DUF924"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23004">
        <property type="entry name" value="DOUBLECORTIN DOMAIN CONTAINING 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23004:SF7">
        <property type="entry name" value="DUF924-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06041">
        <property type="entry name" value="DUF924"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="145"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF75739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="342" mass="39299" checksum="852F0E327CD884E4" modified="2009-11-03" version="1">MHPILRPKSYHKRLLTLQHWTALRPSTSRKTQSASHSWSMRSPTVLQTARARRIHTGPIPRTPPSMSNEPKVDLAMFLGPSLPGRVYNFWFQHVAEDANLTLPTLEVFKPWFTKDAVFDLECATHFKPILAAIHQSHSPHPEPHTPSQTQTPSPSRLEAQAQQILTLIKPTTAHDWLGLIILLDQLPRNCYRGTEAALVYTFFDPICRFIASRALEEGMAVRPEIRYRLALRHWFYLPFMHSEDLGHQELVLRSYQEMADDIRRLLDEPAHGVGEKELSCRVILASNREAVEANLAQSFKFQKEHHDIIARFGRYPYRNGVLGRTTTPEEEKFLSETDISFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>C8V6T2</accession>
    <name>C8V6T2_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">nicotinamidase</fullName>
            <ecNumber evidence="6">3.5.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Nicotinamide deamidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ANIA_03809</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; nicotinate biosynthesis; nicotinate from nicotinamide: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.19" evidence="6"/>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF75336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467444.1">
        <property type="nucleotide sequence ID" value="XM_050611412.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V6T2"/>
    <dbReference type="FunCoup" id="C8V6T2">
        <property type="interactions" value="420"/>
    </dbReference>
    <dbReference type="STRING" id="227321.C8V6T2"/>
    <dbReference type="GeneID" id="74896120"/>
    <dbReference type="KEGG" id="ani:ANIA_03809"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN3809"/>
    <dbReference type="eggNOG" id="KOG4003">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068979_13_2_1"/>
    <dbReference type="InParanoid" id="C8V6T2"/>
    <dbReference type="OMA" id="SGFACAN"/>
    <dbReference type="OrthoDB" id="3341310at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008936">
        <property type="term" value="F:nicotinamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019363">
        <property type="term" value="P:pyridine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052347">
        <property type="entry name" value="Isochorismatase_Nicotinamidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11080:SF2">
        <property type="entry name" value="LD05707P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11080">
        <property type="entry name" value="PYRAZINAMIDASE/NICOTINAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase-like" evidence="8">
        <location>
            <begin position="16"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00043224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBF75336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="155" mass="16488" checksum="6AF76190DB574BCC" modified="2009-11-03" version="1">MTNPAAGKEAETKLQTLWPVHCVQKTPGADIIPELDVTKIDLFVTKGMHPRVEMYSAFADAFGNQDPAIVSVNADLRSFLHDRGVTDVFVVGVAGDFCVKYTALDAAKAGFRSHVVQDATECVVPGSGWEETARELASAGVSIVRSDGPEIVGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>C8V778</accession>
    <name>C8V778_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Thymidylate kinase</fullName>
            <ecNumber evidence="3">2.7.4.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ANIA_08213</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; dTTP biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the thymidylate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.9" evidence="3"/>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF74121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467280.1">
        <property type="nucleotide sequence ID" value="XM_050611233.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V778"/>
    <dbReference type="FunCoup" id="C8V778">
        <property type="interactions" value="742"/>
    </dbReference>
    <dbReference type="STRING" id="227321.C8V778"/>
    <dbReference type="GeneID" id="2868993"/>
    <dbReference type="KEGG" id="ani:ANIA_08213"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN8213"/>
    <dbReference type="eggNOG" id="KOG3327">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049131_3_1_1"/>
    <dbReference type="InParanoid" id="C8V778"/>
    <dbReference type="OMA" id="YWHQFDA"/>
    <dbReference type="OrthoDB" id="425602at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004798">
        <property type="term" value="F:dTMP kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006233">
        <property type="term" value="P:dTDP biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006235">
        <property type="term" value="P:dTTP biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006227">
        <property type="term" value="P:dUDP biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd01672">
        <property type="entry name" value="TMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000679">
        <property type="entry name" value="Thymidylate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00165">
        <property type="entry name" value="Thymidylate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039430">
        <property type="entry name" value="Thymidylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018095">
        <property type="entry name" value="Thymidylate_kin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018094">
        <property type="entry name" value="Thymidylate_kinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00041">
        <property type="entry name" value="DTMP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10344">
        <property type="entry name" value="THYMIDYLATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10344:SF1">
        <property type="entry name" value="THYMIDYLATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02223">
        <property type="entry name" value="Thymidylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01331">
        <property type="entry name" value="THYMIDYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thymidylate kinase-like" evidence="10">
        <location>
            <begin position="16"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CBF74121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="223" mass="24356" checksum="2F08E00CDD6AD3A1" modified="2009-11-03" version="1">MSVNGTHGGRGALIVVEGLDRAGKSSQCKFLHNILQEGGRPVKYIRFPDRTTPIGKLIDGYLRGQSHLDDHSIHLLFSANRWEVAQSIEADIANGTSVIIDRYSYSGAVYSAAKANPSLSLEWAWQPEVGLPKPDLCLFLSISPEEAAKRGGFGGERYENEAMQTRVRELFNTIFDLQRATDIRIIDAGKSLAEVSQDILNVVTERIAGVDTASPLGKLTSIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>C8V7B0</accession>
    <name>C8V7B0_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNP domain protein (AFU_orthologue AFUA_6G12300)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ANIA_03739</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF75495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467466.1">
        <property type="nucleotide sequence ID" value="XM_050611437.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V7B0"/>
    <dbReference type="FunCoup" id="C8V7B0">
        <property type="interactions" value="633"/>
    </dbReference>
    <dbReference type="STRING" id="227321.C8V7B0"/>
    <dbReference type="GeneID" id="2873164"/>
    <dbReference type="KEGG" id="ani:ANIA_03739"/>
    <dbReference type="eggNOG" id="KOG0118">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026447_0_0_1"/>
    <dbReference type="InParanoid" id="C8V7B0"/>
    <dbReference type="OMA" id="GPMNADH"/>
    <dbReference type="OrthoDB" id="1049195at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000145">
        <property type="entry name" value="Putative RNP domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000280">
        <property type="entry name" value="RNA-binding domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:001271">
        <property type="entry name" value="RNP domain protein (AFU_orthologue AFUA_6G12300)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050374">
        <property type="entry name" value="RRT5_SRSF_SR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003:SF3">
        <property type="entry name" value="FI21236P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003">
        <property type="entry name" value="RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="111"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="222"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="381"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="464"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="66"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBF75495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="484" mass="52293" checksum="10F6FA969E309098" modified="2009-11-03" version="1">MPYGDYEYDTDRAQRERSRSPRRRSRSPRRSRRSYSPRSRSRSRDRDDYRRSDRRSRSPMSAAQGPSGGHSGSGYSGRGGSYPPPPRSFEDRAVAKEQMMQSVRESSQQDRRVYVGNLSYDVKWHHLKDFMRQAGDVIFADVLLLPNGMSKGCGIVEYATREQAQNAVNTLSNQNLMNRLVYVREDREPEPRFSGGPSRGDFGGPGRGGFGGYGGGPGGGGRQLYVSNLPFNVGWQDLKDLFRQAAQQGTVIRADVHTDASGRPKGSGIVAFESPDDARNAIQQFNGYDWQGRTLEVREDRFAGSGPGMGRGGYGGFGGRGGFGGRGGFGGRGGFGGGFGGRGGFGGGYGGPPSGPGFDAGPSVPPNPFTDYATSGGEKSNTIYVRNLPWSTCNDDLVDLFSTIGKVERAEIQYEPNGRSRGTGVVQFDNADTAETSIAKFTGYQYGGRPLGITFVKYLTPAQGPADPMDDAQPTGGLTQDQIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>C8V7L8</accession>
    <name>C8V7L8_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">ANIA_03689</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="2"/>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF75602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467484.1">
        <property type="nucleotide sequence ID" value="XM_050611455.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V7L8"/>
    <dbReference type="FunCoup" id="C8V7L8">
        <property type="interactions" value="600"/>
    </dbReference>
    <dbReference type="STRING" id="227321.C8V7L8"/>
    <dbReference type="GeneID" id="2873108"/>
    <dbReference type="KEGG" id="ani:ANIA_03689"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN3689"/>
    <dbReference type="eggNOG" id="KOG1815">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009823_4_1_1"/>
    <dbReference type="InParanoid" id="C8V7L8"/>
    <dbReference type="OMA" id="HRFCMIC"/>
    <dbReference type="OrthoDB" id="10009520at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031624">
        <property type="term" value="F:ubiquitin conjugating enzyme binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd20346">
        <property type="entry name" value="BRcat_RBR_ANKIB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20356">
        <property type="entry name" value="Rcat_RBR_HHARI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16625">
        <property type="entry name" value="RING-HC_RBR_HEL2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1750:FF:000007">
        <property type="entry name" value="RBR-type E3 ubiquitin transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000019">
        <property type="entry name" value="RBR-type E3 ubiquitin transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045840">
        <property type="entry name" value="Ariadne"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048962">
        <property type="entry name" value="ARIH1-like_UBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19422">
        <property type="entry name" value="Ariadne"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22191">
        <property type="entry name" value="IBR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21235">
        <property type="entry name" value="UBA_ARI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00647">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="133"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="137"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="23"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CBF75602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="511" mass="58959" checksum="D38A7134042465C2" modified="2009-11-03" version="1">MESDDDFMSVASSADDFLGTQGSDDESLGDDFGDDFDGGFSKDKDIFSNTRKPYEVDFKVLSPEDIEREQNLQINEVSSILGLPPESSAILLRFGRWNREKLIESYMDHPELTLEEAGLGTNFESTPKTEVVPGFTCDICCEDGDDLETYAMRCGHRFCVDCYRHYLAQKIREEGEAARIQCPGNDCHMIVDSKSLSLLVTDDLKDRYQTLLTRTYVDDKENLKWCPAPNCEYAVDCHVKQRELHRIVPTVQCGCKHYFCFGCTLNDHQPSPCRLVKMWLQKCEDDSETANWISANTKECPKCHSTIEKNGGCNHMTCRKCKHEFCWMCMGLWSEHGTSWYNCNRFEEKSGAEARTEQARSRASLERYLHYYNRYANHEQSAKLDKDLYLKTEKKMTSLQSQSGLSWIEVQFLDTASQALQQCRQTLKWTYAFAYYLARNNLTEIFEDNQKDLEMAVESLSEMFEKPVGELANLKVDILDKTAYCNKRRVILLSDTAENLKNGVWQFNVEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2025-10-08" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>C8V8I4</accession>
    <name>C8V8I4_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ANIA_04457</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the proteasome complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peptidase T1B family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF77481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_662061.2">
        <property type="nucleotide sequence ID" value="XM_656969.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V8I4"/>
    <dbReference type="FunCoup" id="C8V8I4">
        <property type="interactions" value="1033"/>
    </dbReference>
    <dbReference type="STRING" id="227321.C8V8I4"/>
    <dbReference type="MEROPS" id="T01.984"/>
    <dbReference type="GeneID" id="2872257"/>
    <dbReference type="KEGG" id="ani:ANIA_04457"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN4457"/>
    <dbReference type="eggNOG" id="KOG0177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035750_12_0_1"/>
    <dbReference type="InParanoid" id="C8V8I4"/>
    <dbReference type="OMA" id="MKRDHDK"/>
    <dbReference type="OrthoDB" id="268428at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061133">
        <property type="term" value="F:endopeptidase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010499">
        <property type="term" value="P:proteasomal ubiquitin-independent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd03758">
        <property type="entry name" value="proteasome_beta_type_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000008">
        <property type="entry name" value="Proteasome subunit beta type-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035206">
        <property type="entry name" value="Proteasome_beta2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF2">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA TYPE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 5 6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBF77481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="203" mass="22727" checksum="586BFB617A6318A6" modified="2009-11-03" version="1">MEVLLGITGRDFVILAASKAAMRGPTILKAEDDKTRQLNEHTLVAFSGEAGDTVQFAEYVQANVQLYTMRNDTELSPNAVANFVRGELARSLRSRNPYTVNLLLGGVDPISQKPHLYWIDYLASLASVPYAAHGYAQYYCLSTLDKHHHPDITLEQGMKLLEMCTDELKRRLPIDYKGVLVKVVTKDGVRVEDFDNNRIVKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>C8V998</accession>
    <name>C8V998_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NADH-ubiquinone oxidoreductase subunit B, putative (AFU_orthologue AFUA_4G05860)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ANIA_04297</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the complex I 20 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF77819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467758.1">
        <property type="nucleotide sequence ID" value="XM_050611771.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V998"/>
    <dbReference type="STRING" id="227321.C8V998"/>
    <dbReference type="GeneID" id="2872097"/>
    <dbReference type="KEGG" id="ani:ANIA_04297"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN4297"/>
    <dbReference type="eggNOG" id="KOG1687">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055737_1_0_1"/>
    <dbReference type="InParanoid" id="C8V998"/>
    <dbReference type="OMA" id="GCGGIEM"/>
    <dbReference type="OrthoDB" id="268400at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009060">
        <property type="term" value="P:aerobic respiration"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015990">
        <property type="term" value="P:electron transport coupled proton transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12280:FF:000001">
        <property type="entry name" value="NADH-quinone oxidoreductase subunit B 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01356">
        <property type="entry name" value="NDH1_NuoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006137">
        <property type="entry name" value="NADH_UbQ_OxRdtase-like_20kDa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006138">
        <property type="entry name" value="NADH_UQ_OxRdtase_20Kd_su"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01957">
        <property type="entry name" value="nuoB_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005012">
        <property type="entry name" value="PRK06411.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11995">
        <property type="entry name" value="NADH DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11995:SF14">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01058">
        <property type="entry name" value="Oxidored_q6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56770">
        <property type="entry name" value="HydA/Nqo6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01150">
        <property type="entry name" value="COMPLEX1_20K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:ubiquinone oxidoreductase-like 20kDa subunit" evidence="5">
        <location>
            <begin position="103"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBF77819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="228" mass="25720" checksum="2D0BE2DAD61A3CD6" modified="2009-11-03" version="1">MFSLSGRAFVRTLHVRPNRGSFAPQYQRVELLSTSAIKAATALERQGNAGQSLTASGQVRREVPLPSQEKKEGAMQYVLTTLDQVANWARQSSLWPMTFGLACCAVEMMHLSTPRYDQDRLGIIFRASPRQSDVMIVAGTLTNKMAPALRQVYDQMPDPRWVISMGSCANGGGYYHYSYSVVRGCDRIVPVDVYVPGCPPTSEALMYGIFQLQKKMRHTRITRMWYRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>C8VA69</accession>
    <name>C8VA69_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">G-patch domain protein, putative (AFU_orthologue AFUA_3G07480)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">ANIA_04850</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="16">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF76633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467611.1">
        <property type="nucleotide sequence ID" value="XM_050611598.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VA69"/>
    <dbReference type="STRING" id="227321.C8VA69"/>
    <dbReference type="GeneID" id="2872650"/>
    <dbReference type="KEGG" id="ani:ANIA_04850"/>
    <dbReference type="eggNOG" id="KOG0154">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012131_1_0_1"/>
    <dbReference type="InParanoid" id="C8VA69"/>
    <dbReference type="OMA" id="AHPYSFQ"/>
    <dbReference type="OrthoDB" id="29221at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1060.10">
        <property type="entry name" value="Zinc finger, RanBP2-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055494">
        <property type="entry name" value="DUF7066"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036443">
        <property type="entry name" value="Znf_RanBP2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13948:SF3">
        <property type="entry name" value="FI21118P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13948">
        <property type="entry name" value="RNA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23217">
        <property type="entry name" value="DUF7066"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00641">
        <property type="entry name" value="Zn_ribbon_RanBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90209">
        <property type="entry name" value="Ran binding protein zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="133"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="14">
        <location>
            <begin position="254"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="313"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="561"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="domain" description="G-patch" evidence="13">
        <location>
            <begin position="651"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="281"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="339"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="469"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="529"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="608"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="693"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="36"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="83"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="95"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="529"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="615"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="705"/>
            <end position="734"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CBF76633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="734" mass="82526" checksum="887FF95101494954" modified="2009-11-03" version="1">MSHLQPEDTRYLPGPPPRPFPRRDDRDGRMYDDNSPSRSRSPGGPSHTPPRGPAADRRRDYSRGHSGSRSRYRSRDRDEFRRRSSRSPPRRPRHGYRDRDREGYRSRSRSRSYSRSRSRSPRRGRSYYGQESREVMMDGLPVDMVEEDVGQLLPSLSAQTQYPKVALQAFISRELKDFYHIDGLEEVRVIRDRQTRISRQLGFLRFRSLNHSRAFMEQNFPTIYLCGPSAQDDRGTKVRIAYSREKEDRAKARAEGDWTCKMCSIVNYSTRHKCFRCQAPRPDAGPTGPPGIAPPKVKNHGDNDAAPENQPSQFLLFRGLETSVTEELLAKGVAKLYRPNSDGNSANQKKGAKVASTTGDSNLGAREGSIRRVLLVRDRRTNESWRYGFAEFATIQDAQAAISRLHSFEKFTISSRPVMVSYIHAGVFVPVMNPSESTEKFTFSPLNNPAMKLMYWDEDAYVMELTVSTEPAPQGSDKPAAQQEGKAKEASDKAKKRKADAASSASGTKKMAMPSHLQFWSNRHAELHGIKKDPEGKGSADQNSSDEAAAPPRQSYADPNRNCCYLCMRQFKTMAEVNRHERLSQLHRGNLQKDEVVAKATNKLIKHGIIPQPPEYRDRARERRQAFGRSKNATAKPAPPPEREPSPPVQTTSKGASLLSKMGWSAGTGLGAQGTGMTAPITTEVYAQGVGLGAQGGKLGEASEEAARNTRNRYDEFLEKTRQTARERYEQLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>C8VBU0</accession>
    <name>C8VBU0_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Zn(II)2Cys6 transcription factor (Eurofung)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ANIA_07596</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF79709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467993.1">
        <property type="nucleotide sequence ID" value="XM_050612032.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VBU0"/>
    <dbReference type="GeneID" id="2869673"/>
    <dbReference type="KEGG" id="ani:ANIA_07596"/>
    <dbReference type="eggNOG" id="ENOG502QPVP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011455_2_0_1"/>
    <dbReference type="InParanoid" id="C8VBU0"/>
    <dbReference type="OMA" id="IRCDVEQ"/>
    <dbReference type="OrthoDB" id="3163292at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.240.10:FF:000164">
        <property type="entry name" value="Putative Zn(II)2Cys6 transcription factor (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF21">
        <property type="entry name" value="REGULATORY PROTEIN LEU3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="32"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="8"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="629"/>
            <end position="648"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBF79709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="667" mass="74037" checksum="8A1CA45D6478E981" modified="2009-11-03" version="1">MLSLYEMLDSGGGIPDADDSRPTSVSKRSKKACTQCRQQKARCDAYQKQPCSRCEKLGIECVKYERLEKETDELRKQLNAHTASLHQIRESATTMMPRPNPADNVKRNKATGVCIDANDAEISCSNGAESLQLLFQDIASDGLPHLTAATSESPSSNGSKLPEMVPGSIYKNTASGQTRLQPLQPPVGMGPVVSKKKNLAMAGVDPDRTLPRTLGGVTLSGDEIDEIFNIFYRQYVVFMPCLDTESSPNLTYEQSDFLFWTIIGTASRTCAKNPTIFPALAKHIISMAFLSPLSESGAWNIVQGLLLVLNWPFPKADGGVDIIFPLTGLLLHVAMMYGMHNPVSSHEFFKTKQPMPQVADISRRSELWAYTVITYQRACLMKGQPPRTLPDMAHDVNQRKTLYQNMSPHVRTRMKAQEIVTQCGAAVNEYGVLTLSAADEGGLDLLLKAYEQRVNDLHIDATTWMARFDILVACLSIQGMHFLKNHTLYADNRLRKLEAAACAVIDAVADMARELQSLAVCPSQGWFGLLLAGSILLRIIKGHDTDIVDFAKARNYFMKSLNLAKLMIVDNADMPTKVVTVLSHLYNSTKAFRKADGSVMINLRIRSRLALCPIIDAMWWFKDEFEPPLPTTEENTEKPPTGPEGSANHLYDDGFWTDLEWALNIPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>C8VC55</accession>
    <name>C8VC55_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ANIA_10992</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF79919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468023.1">
        <property type="nucleotide sequence ID" value="XM_050612064.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VC55"/>
    <dbReference type="GeneID" id="2869393"/>
    <dbReference type="KEGG" id="ani:ANIA_10992"/>
    <dbReference type="HOGENOM" id="CLU_1677869_0_0_1"/>
    <dbReference type="InParanoid" id="C8VC55"/>
    <dbReference type="OrthoDB" id="5086080at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021833">
        <property type="entry name" value="DUF3425"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37012">
        <property type="entry name" value="B-ZIP TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37012:SF7">
        <property type="entry name" value="B-ZIP TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11905">
        <property type="entry name" value="DUF3425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF79919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="157" mass="17021" checksum="12E10B4DAB86A74B" modified="2009-11-03" version="1">MVSHAPIIDFFAWPNLRDHLIVSGITHISETTAALYVSQIRLKWPYELRDVCKYNVAEDRYRFSSEFDAVYYDVRNWTIDSPQLQILIESGPDVAGFDFGNINGVGAGAGATIGSAQGGGLGVGEDGDRGGSGDGKGFADDVDSAYWDRFLGGCDQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>C8VEG4</accession>
    <name>C8VEG4_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ANIA_11614</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF80584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468099.1">
        <property type="nucleotide sequence ID" value="XM_050612147.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VEG4"/>
    <dbReference type="GeneID" id="74897175"/>
    <dbReference type="KEGG" id="ani:ANIA_11614"/>
    <dbReference type="HOGENOM" id="CLU_3191310_0_0_1"/>
    <dbReference type="InParanoid" id="C8VEG4"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF80584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="46" mass="5604" checksum="DB5A044341D72CDF" modified="2009-11-03" version="1">MAMHFRLLLIKAMRKWYRYCWIKAQRSLLKVERLRSGTEPPIMAPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>C8VEW6</accession>
    <name>C8VEW6_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">MFS monosaccharide transporter, putative (AFU_orthologue AFUA_1G07700)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ANIA_05104</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF80868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468133.1">
        <property type="nucleotide sequence ID" value="XM_050612187.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VEW6"/>
    <dbReference type="GeneID" id="2871391"/>
    <dbReference type="KEGG" id="ani:ANIA_05104"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN5104"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_25_1_1"/>
    <dbReference type="InParanoid" id="C8VEW6"/>
    <dbReference type="OMA" id="GVFVYYM"/>
    <dbReference type="OrthoDB" id="648285at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000119">
        <property type="entry name" value="MFS monosaccharide transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF73">
        <property type="entry name" value="METABOLITE TRANSPORT PROTEIN YDL199C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="269"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="305"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="334"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="367"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="430"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="23"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="471"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="514"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="548"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="559"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CBF80868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="576" mass="63258" checksum="16201EB6AD012919" modified="2009-11-03" version="1">MSPGSRQSTQTHGLVGKPLLYFTSVFVSLGVFLFGYDQGVMSGIITGLYFKDYFNQPSRAEIGTVVAILEVGAFISSLLVGKIGDLIGRRRTILYGSMVFFVGGAFQTFATGLPMMMLGRIVAGLGVGALSTIVPVYQSEISPPHNRGKLACIEFTGNIFGYAASVWVDYFCSFIRSDFSWRLPLLLQCIMGFLLGLGSLIICESPRWLLDNDHDEEGMVVIANLYGKGDLHNPEAQREYREIKMNVLITRQEGERSYVDMFKRYNRRVLIAMSAQALAQLNGINVISYYAPLVFESAGWAGRDAILMTGINGLTYLASTVPPWYLVDGWGRRPILLSGALAMVLSLSAISYFIFIDIEATPTLTVIFVMIYNAAFGASWGPIPWLYPPEILPLSIRAKGASLSTATNWAFNWLVGEVTPVLQAAIKWRLYLVHAFFCACSFVVVWFLYPETSGVRLEDMDVLFGDATTAMPTPATQGERGSLMSTGSPVPSLDIRRQYGQHGADSAIPGLNINPPNVTGENNGKSPQTGPQDDNGSRPEGLGGWISNIVSRNMGSSNRPHDTQYRRLEQDEEAEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>C8VFI1</accession>
    <name>C8VFI1_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_10727</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF81265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468195.1">
        <property type="nucleotide sequence ID" value="XM_050612253.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VFI1"/>
    <dbReference type="GeneID" id="74896567"/>
    <dbReference type="KEGG" id="ani:ANIA_10727"/>
    <dbReference type="HOGENOM" id="CLU_2638061_0_0_1"/>
    <dbReference type="InParanoid" id="C8VFI1"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF81265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="77" mass="8720" checksum="C08BEA8E4FFB6C3E" modified="2009-11-03" version="1">MPKRLSAIINFTTTLRVVSRRPVSGSGTRAVLIYSETDESRIKWLMPGMQSKQCTNRDNQKTQKTKAQIRRSKAVAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="101" xmlns="https://uniprot.org/uniprot">
    <accession>C8VFJ7</accession>
    <name>C8VFJ7_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Calcium-transporting ATPase</fullName>
            <ecNumber evidence="15">7.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">ANIA_05743</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="18">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes the hydrolysis of ATP coupled with the transport of calcium.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19 15">
            <text>Ca(2+)(in) + ATP + H2O = Ca(2+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Membrane</location>
            <topology evidence="15">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14 15">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.10" evidence="15"/>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF81294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_663347.2">
        <property type="nucleotide sequence ID" value="XM_658255.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VFJ7"/>
    <dbReference type="STRING" id="227321.C8VFJ7"/>
    <dbReference type="GeneID" id="2872032"/>
    <dbReference type="KEGG" id="ani:ANIA_05743"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN5743"/>
    <dbReference type="eggNOG" id="KOG0202">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002360_3_2_1"/>
    <dbReference type="InParanoid" id="C8VFJ7"/>
    <dbReference type="OMA" id="PLWNNMM"/>
    <dbReference type="OrthoDB" id="3352408at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070588">
        <property type="term" value="P:calcium ion transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd02083">
        <property type="entry name" value="P-type_ATPase_SERCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000005">
        <property type="entry name" value="Calcium-transporting ATPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000021">
        <property type="entry name" value="calcium-transporting ATPase, endoplasmic reticulum-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000037">
        <property type="entry name" value="Calcium-transporting ATPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000014">
        <property type="entry name" value="Calcium-transporting ATPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000065">
        <property type="entry name" value="Sarcoplasmic/endoplasmic reticulum calcium ATPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005782">
        <property type="entry name" value="P-type_ATPase_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01116">
        <property type="entry name" value="ATPase-IIA1_Ca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08282">
        <property type="entry name" value="Hydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00121">
        <property type="entry name" value="NAKATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 15" id="KW-0106">Calcium</keyword>
    <keyword evidence="3 15" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="12 15" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 15" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="61"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="256"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="288"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="754"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="787"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="827"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="890"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="922"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="16">
        <location>
            <begin position="3"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CBF81294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="1006" mass="108620" checksum="62A9EBBF631F8D08" modified="2009-11-03" version="1">MEQSYILAPAEVLKHFDVTERSGLSSAQVSHSRQKYGPNALAEEPPTPLWELVLEQFKDQLVLILLGSAAVSFVLALFEESDDWTVFVDPAVILTILILNAIVGVTQESSAEKAIAALQEYSANEAKVVRDGVVQRIKAEDLVPGDIVHVAVGDRVPADCRLLAIHSNSFRVDQAILTGESESVAKDTRAVSDRQAVKQDQTNILFSGTTVVNGNATAVVVLTGSSTAIGDIHESITSQISEPTPLKQKLNDFGDMLAKVITVICILVWVINIEHFNDPSHGGWAKGAIYYLKIAVSLGVAAIPEGLAVVITTCLALGTRKMAQKNAVVRSLPSVETLGSCSVICSDKTGTLTTNQMSVGKIVYLSQLGTGVEVIDVEGTTFAPEGSLSYNGQVVTNLAASSSTIRQMAEVMARCNAAAIAYDEKTGTFSCIGEPTEGALRVLVEKIGTDDAAMNDKLLSLPASQKLHVSSAYYESRLPLQATYEFSRDRKSMSVLVGTGSNRRLLVKGAPESILERCSYALLGPNGARVSLTKAHLDLLSSEVVEYASRGLRVIALASVDDVGANPLIHKASTSEEYAQLEQNMTLIGLVAMLDPPRVEVADSIKKCAEAGIRVIVITGDNQNTAESICREIGVFGKDEDLKGKSFTGREFDSLSHNEQLEAVKSASLFSRTEPSHKSKLVDLLQSLGHVVAMTGDGVNDAPALKKSDIGVAMGTGTDVAKLAADMVLVDDNFATITTAVEEGRSIYSNTQQFIRYLISSNIGEVVSIFLTAALGMPEALVPVQLLWVNLVTDGLPATALSFNPADHDVMRRPPRKRDEPLVGGWLLFRYLVIGTYVGAATVFGYVWWFLYNPEGPQISFWQLSHFHKCSTEFPEIGCEMFSNDMSRSASTVSLSILVVIEMLNAMNALSSSESLLTFGLWNNMMLVYAIILSMTLHFAILYIPFLQGLFAILPLDWTEWKAVLAISAPVVVIDEILKVVERRLYNTTVTAPVKENGAILKPKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>C8VFX5</accession>
    <name>C8VFX5_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="6">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ANIA_05623</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="6">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="6"/>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF81531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468224.1">
        <property type="nucleotide sequence ID" value="XM_050612283.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VFX5"/>
    <dbReference type="STRING" id="227321.C8VFX5"/>
    <dbReference type="GeneID" id="2871913"/>
    <dbReference type="KEGG" id="ani:ANIA_05623"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN5623"/>
    <dbReference type="eggNOG" id="KOG0342">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_26_6_1"/>
    <dbReference type="InParanoid" id="C8VFX5"/>
    <dbReference type="OMA" id="NGEQYVH"/>
    <dbReference type="OrthoDB" id="193716at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17964">
        <property type="entry name" value="DEADc_MSS116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="43"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="257"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="494"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="535"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="553"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBF81531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="567" mass="60700" checksum="05D4819A854CE5EC" modified="2009-11-03" version="1">MQSATDGLQPYSSMAGKLDQKLLQALNVLGFEYMSPVQQRVLTELPTWRSDCLVQAKTGTGKTVAFLLPALHCLIQGQSQVRRGQVAILIITPTRELAQQIAKSCDELTSQLSRPLECHIAVGGTARASAHSRFMNGDPSILVATPGRLKDYLSESETAEKLKDIQTLVLDEADTMLETGFLADVKQILKLIPSKSTGWQGMCFSATLPPKVKDVVSVVLNPGYTSISTVDKNEPPTHERVPQYYVLMPSVAETFTTLSSLLAHESKKNTKIIVFGVTANMVALSHSAFANGLTPLKVFEIHSRLSQSARTRTTSQFKEADAGILFASDVIGRGMDFPNVDLVVQVGLPSNAEQYVHRVGRTARAGNDGRAVILLTESESFFLKANRHLPIQPHPDASSILANATSCSPAVTQAMYAVDETTKQRAYSSYIGFFAGSGLMKQLRLDKPGLVQLANELAIKGMACPEPPPMDKKIVGKMGLKGVPGFNYASAEQLAAARPKHRGPPHAKANGNGTGTNGTPPHARARDAPSAGTGRGERNGGEKRRGGRRGGRAGRGANGGRGGQQSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C8VIA1</accession>
    <name>C8VIA1_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Copper transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ANIA_03209</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF83186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_660813.2">
        <property type="nucleotide sequence ID" value="XM_655721.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VIA1"/>
    <dbReference type="FunCoup" id="C8VIA1">
        <property type="interactions" value="25"/>
    </dbReference>
    <dbReference type="STRING" id="227321.C8VIA1"/>
    <dbReference type="GeneID" id="2873973"/>
    <dbReference type="KEGG" id="ani:ANIA_03209"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN3209"/>
    <dbReference type="eggNOG" id="KOG3386">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079690_0_1_1"/>
    <dbReference type="InParanoid" id="C8VIA1"/>
    <dbReference type="OMA" id="QFAVSCI"/>
    <dbReference type="OrthoDB" id="161814at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005375">
        <property type="term" value="F:copper ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007274">
        <property type="entry name" value="Cop_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483:SF79">
        <property type="entry name" value="COPPER TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 31 COPPER TRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04145">
        <property type="entry name" value="Ctr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="4" id="KW-0187">Copper transport</keyword>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBF83186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="188" mass="20801" checksum="4DDAF24F0D897992" modified="2009-11-03" version="1">MEHTHSTLLPRMAGMDMSSSATNASCSVEMLWNWKVIDSCFLSSTWHVTTKGMFAVSCIGVALLGVALEFLRRVSKDYEESLQRQFQRHAIAQLDDPLVCGVPASVVTYRASPLQQIIRAVLHVAQFGVAYITMLIAMYYNGYMIISIFIGAFLGKLFFDWGQYKVVLGQTQGPAAAKVEEEATKCCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>C8VJN3</accession>
    <name>C8VJN3_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">DASH complex subunit SPC34</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Outer kinetochore protein SPC34</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">ANIA_02768</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="22" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="22">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex SPC34 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF84051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468547.1">
        <property type="nucleotide sequence ID" value="XM_050612650.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VJN3"/>
    <dbReference type="STRING" id="227321.C8VJN3"/>
    <dbReference type="GeneID" id="2873777"/>
    <dbReference type="KEGG" id="ani:ANIA_02768"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN2768"/>
    <dbReference type="eggNOG" id="ENOG502SCS2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064328_0_0_1"/>
    <dbReference type="InParanoid" id="C8VJN3"/>
    <dbReference type="OMA" id="TRRGTMF"/>
    <dbReference type="OrthoDB" id="10016597at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013966">
        <property type="entry name" value="Spc34"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08657">
        <property type="entry name" value="DASH_Spc34"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="16" id="KW-0137">Centromere</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="12 19" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="8" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9" id="KW-0498">Mitosis</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="55"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="153"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00044346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="CBF84051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="245" mass="27298" checksum="66270997EACC0F38" modified="2009-11-03" version="1">MSLLESHLEQIMLSSNAIAELPFPQPRIFTNALLGSHDITALIRDTEAHERALFQSDPTVKASNSQKRATRRATQFQPEAETESMASRIYSARNSRNNSAVARVLGSDMMDEIKRSARTSTNGSRGEVNIDVLLKGAEILCNVYPVAGAQDKIASLRYRNQVISESIAELEERVARNASELESMSHLHDDDYDELDNASSPSAGVLDVTDADIERELKEIRELERRKRNLEDRVNGMERDLGGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>C8VNG3</accession>
    <name>C8VNG3_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ANIA_02358</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF86684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468872.1">
        <property type="nucleotide sequence ID" value="XM_050613030.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VNG3"/>
    <dbReference type="FunCoup" id="C8VNG3">
        <property type="interactions" value="177"/>
    </dbReference>
    <dbReference type="GeneID" id="2875168"/>
    <dbReference type="KEGG" id="ani:ANIA_02358"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN2358"/>
    <dbReference type="eggNOG" id="KOG2504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_1_0_1"/>
    <dbReference type="InParanoid" id="C8VNG3"/>
    <dbReference type="OMA" id="LYWHFVL"/>
    <dbReference type="OrthoDB" id="410267at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF177">
        <property type="entry name" value="RIBOFLAVIN TRANSPORTER MCH5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="126"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="261"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="291"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="324"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="349"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="384"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="415"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="5">
        <location>
            <begin position="56"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBF86684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="448" mass="48615" checksum="36BCA33414BAF958" modified="2009-11-03" version="1">MDTKGAQLQTTSGYELAESSRAVNRERPVEYPSTESSTPLVESNDADDFPDGGIRSWLVVLGSFFLLMASYGLMNSVGVIQSYLETHQLSHYSSRDVGWISGVFVFTSLILGIFVGPLFDAYGPKELVAVGTGIYSLGVLLTAQCTQYWHFILCFGVIAGIGAAVISNVGMSCIPHWFYAKAGMAIGTAMAGAGLGGVVFPYILRETWTSIGFKWGMRVTALLVLLLCGSATFLVKSRLPRNGRPKAAFDIRCFKDARFSWLSAATFCLELVVFGLLGILPSYVVAQGFSAASSVNLLVVMNVCNSIGRLVSGRVADKYGRLNVLILLVAMAVILIFAILYPFSNSLPALYIFCATYGFVSGSFICLAPVCVRQISPAKETGMRFGTLYGLVAFATLICIPIGGEMLEKIGAHMVVVYLGVMLVVAILFFVIARWACLDYKWNWWSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>C8VP81</accession>
    <name>C8VP81_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Chitin deacetylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">ANIA_10309</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF86904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468898.1">
        <property type="nucleotide sequence ID" value="XM_050613056.1"/>
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    <dbReference type="AlphaFoldDB" id="C8VP81"/>
    <dbReference type="SMR" id="C8VP81"/>
    <dbReference type="STRING" id="227321.C8VP81"/>
    <dbReference type="CAZy" id="CBM18">
        <property type="family name" value="Carbohydrate-Binding Module Family 18"/>
    </dbReference>
    <dbReference type="GeneID" id="74896329"/>
    <dbReference type="KEGG" id="ani:ANIA_10309"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN10309"/>
    <dbReference type="eggNOG" id="ENOG502S2CW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021264_11_3_1"/>
    <dbReference type="InParanoid" id="C8VP81"/>
    <dbReference type="OMA" id="HEQTAMN"/>
    <dbReference type="OrthoDB" id="407355at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10951">
        <property type="entry name" value="CE4_ClCDA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00035">
        <property type="entry name" value="ChtBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11618">
        <property type="entry name" value="ChtBD1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.10">
        <property type="entry name" value="Endochitinase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001002">
        <property type="entry name" value="Chitin-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036861">
        <property type="entry name" value="Endochitinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46471">
        <property type="entry name" value="CHITIN DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46471:SF4">
        <property type="entry name" value="CHITIN DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00270">
        <property type="entry name" value="ChtBD1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57016">
        <property type="entry name" value="Plant lectins/antimicrobial peptides"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50941">
        <property type="entry name" value="CHIT_BIND_I_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2 9" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="8" id="KW-0170">Cobalt</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0843">Virulence</keyword>
    <feature type="domain" description="Chitin-binding type-1" evidence="10">
        <location>
            <begin position="55"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="11">
        <location>
            <begin position="132"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-1" evidence="10">
        <location>
            <begin position="367"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="65"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="70"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="370"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="384"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CBF86904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="467" mass="51054" checksum="38A75F40A7BE20A1" modified="2009-11-03" version="1">MHVPYLLIASSLNFMPSVFGRNIIDLPSDYETVQVASHLQGPGTIQNLLERDLGGARCGAGYGRCSNGNCCSTAGYCGNTTAHCRSPDCQIDYGHCDAHATPGGPSTEAIPRPKLGKVAYGPTAIRSCTTPGTVALTYDDGPNQYTRDLLDLLDKYDAKVTFFVTGNNNGKGQIDSPEVPWAPLIQRMVLSGHQVASHTWSHQDLNKISQVQRRTQLLWNEVALRNILGYFPTYMRPPYSSCTTDTGCLSDMGDLGYHVILYDIDTEDYSHDSPDTIQRSKDIFDENLAREKSFYKSWLVIAHDVHEQTVHNLTEHMLQKLMVDGYRAVTVGECLGDPVQNWYRRDDQVKVPGNPKPKPPLEDISTDGKCGGKVSCIGSDFGMCCGGKGYCGNTTEYCGEGCQPNAGYCESDFLDSSQQTGPGIVGSDPLGDSINKDKKFFKSNASSRFGRTSLTLASIFLFALALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C8VSU6</accession>
    <name>C8VSU6_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thioesterase family protein (AFU_orthologue AFUA_1G10800)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_01196</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF87955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050469024.1">
        <property type="nucleotide sequence ID" value="XM_050613191.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VSU6"/>
    <dbReference type="FunCoup" id="C8VSU6">
        <property type="interactions" value="75"/>
    </dbReference>
    <dbReference type="STRING" id="227321.C8VSU6"/>
    <dbReference type="GeneID" id="2876975"/>
    <dbReference type="KEGG" id="ani:ANIA_01196"/>
    <dbReference type="eggNOG" id="KOG4781">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052827_0_1_1"/>
    <dbReference type="InParanoid" id="C8VSU6"/>
    <dbReference type="OMA" id="FIEPKNA"/>
    <dbReference type="OrthoDB" id="506431at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="CDD" id="cd03443">
        <property type="entry name" value="PaaI_thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052061">
        <property type="entry name" value="PTE-AB_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47260:SF7">
        <property type="entry name" value="THIOESTERASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_1G10800)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47260">
        <property type="entry name" value="UPF0644 PROTEIN PB2B4.06"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="Thioesterase" evidence="2">
        <location>
            <begin position="196"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF87955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="318" mass="35223" checksum="AA7863B32C98FA25" modified="2009-11-03" version="1">MSRLHVPGSSTKALGLARFPQFPLSSRSLQRPYTTVGGFSLPVALYDFGLLNGEVLVPKPPSRLRRLLGFTSIAAFAFTAGLFYQVSTKLLPIMNGPVPTDEETLTMYTPSDELSQEVEDHIKNHPLFVSLREDPSYVESRPYMKIPEKIRDRSLTAGTLSNSGGIVVPPTAFYNNDTNTLVTFFYLGSRVSGHPGIVHGGFLATLLDEGMGRCAFPVLPNKVGVTANLNVDYRRPAMANSYFVMHAQVVKSEGRKAWVEARIETLPEEGQEPVVLVEAKSLFIEPKQAAAVVSYPYIERFSRVTNRFQSPKLHKFVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>C8VT28</accession>
    <name>C8VT28_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">60S ribosomal protein L6 (AFU_orthologue AFUA_1G11130)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ANIA_01166</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL6 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF88013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050469035.1">
        <property type="nucleotide sequence ID" value="XM_050613202.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VT28"/>
    <dbReference type="FunCoup" id="C8VT28">
        <property type="interactions" value="1141"/>
    </dbReference>
    <dbReference type="STRING" id="227321.C8VT28"/>
    <dbReference type="GeneID" id="2876942"/>
    <dbReference type="KEGG" id="ani:ANIA_01166"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN1166"/>
    <dbReference type="eggNOG" id="KOG1694">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066767_2_0_1"/>
    <dbReference type="InParanoid" id="C8VT28"/>
    <dbReference type="OMA" id="KWYNADD"/>
    <dbReference type="OrthoDB" id="2436667at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030684">
        <property type="term" value="C:preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd13156">
        <property type="entry name" value="KOW_RPL6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000014">
        <property type="entry name" value="60S ribosomal protein L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000915">
        <property type="entry name" value="60S_ribosomal_eL6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041997">
        <property type="entry name" value="Ribosomal_eL6_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10715">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10715:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01159">
        <property type="entry name" value="Ribosomal_L6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBF88013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="198" mass="22138" checksum="1074098EA4AF8438" modified="2009-11-03" version="1">MSDVGTTKQFGKAQRLVPSQKAQKWYPVDDESQPKKVRKAIRPTKLRESLQPGTVLILLAGRFRGKRVVLLKHLDQGVLLVTGPFKINGVPLRRVNARYVIATSTRIDISGVDSQTIEKVSAPGYFTKEKKNEKKTEEAFFKQGEKPEKKVVASARASDQKAVDQSILASIKKEAFLGSYLAATFSLRNGDKPHEMKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>C8VT93</accession>
    <name>C8VT93_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_00438</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF89483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050469221.1">
        <property type="nucleotide sequence ID" value="XM_050613403.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VT93"/>
    <dbReference type="STRING" id="227321.C8VT93"/>
    <dbReference type="GeneID" id="2876206"/>
    <dbReference type="KEGG" id="ani:ANIA_00438"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN0438"/>
    <dbReference type="eggNOG" id="ENOG502SHH7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048612_1_0_1"/>
    <dbReference type="InParanoid" id="C8VT93"/>
    <dbReference type="OMA" id="GSFGAHI"/>
    <dbReference type="OrthoDB" id="4106209at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF89483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="300" mass="33741" checksum="846042C062778B01" modified="2009-11-03" version="1">MHKPSLAQIVHRATFPRQRTSDPATFAAHIALNLVPEVRIETSTFYGSLDSVEAQYPGLDYSYGPHRMRLSRFPWHRKLFRVFDELGLTEAEISSLCRWEGTKSARQRYEKEEGVKVRDTTADAIRPASPCPRPSVTVHVEDGPEPIRETEVKTTTYEETEVQNEAVNDRGIDCVLPAEETEESSEEEMESCGVELHHRLLAATAARERGANVPLDEDWEQWLKEAGERGSYTDVLNAIRRGQPLNYLYDLPASISQAGRSSIPQSVSLSEPLDLLTSSRLFSTSNDIRPPPHSPARTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>C8VTS6</accession>
    <name>C8VTS6_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosome assembly protein 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Notchless protein homolog 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Ribosome biogenesis factor RSA4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">ANIA_10058</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the NLE1/RSA4 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF89641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050469242.1">
        <property type="nucleotide sequence ID" value="XM_050610964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VTS6"/>
    <dbReference type="FunCoup" id="C8VTS6">
        <property type="interactions" value="721"/>
    </dbReference>
    <dbReference type="STRING" id="227321.C8VTS6"/>
    <dbReference type="GeneID" id="2876140"/>
    <dbReference type="KEGG" id="ani:ANIA_10058"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN10058"/>
    <dbReference type="eggNOG" id="KOG0271">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_57_16_1"/>
    <dbReference type="InParanoid" id="C8VTS6"/>
    <dbReference type="OMA" id="AWEPYHR"/>
    <dbReference type="OrthoDB" id="10267436at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110136">
        <property type="term" value="P:protein-RNA complex remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000092">
        <property type="entry name" value="notchless protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012972">
        <property type="entry name" value="NLE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001632">
        <property type="entry name" value="WD40_G-protein_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF0">
        <property type="entry name" value="NOTCHLESS PROTEIN HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08154">
        <property type="entry name" value="NLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00319">
        <property type="entry name" value="GPROTEINB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 9" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="NLE" evidence="11">
        <location>
            <begin position="36"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="144"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="187"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="230"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="278"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="401"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="443"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="485"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00061016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00068030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00077034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00080836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CBF89641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="518" mass="56671" checksum="D6494D6330C99E8E" modified="2009-11-03" version="1">MATLLPPPSKRQKTETAEKARLQQEIQGIPDDLGSVRVQFFDQATGSATGPAVSVPVADATVKNLETLLNTLQGNEEDERVPYRFTFQSDDKDSKDSQTIDILADIYHSLLKPGVKTTEDTIQLYFTPQAIFRVKAVSRCSASIAGHGEAILATSFSPVSSSTMVSGSGDSTARIWDCDTGTPLHTLKGHTSWVLAVSYSPNGAMIATGSMDNTVRIWDAKKGQALGAPLKGHVKWITSLAWEPYHLQQSGHPRLASASKDSTVRIWDVISKRADIVLSGHKGSVTCVRWGGTGKIYTSSHDRTIKVWNSQTGTLIQTLSAHAHRVNHLALSTDFILRTAYHDHTGKVPESDADKVAMAKKRFEKAATINNKIVEKLVSASDDFTMYLWDPESSSKPVARLLGHQKEVNHVTFSPDMAYIASAGFDNHVKLWNGRDGKFITTLRGHVGAVYQCCFSADSRLLVSSSKDTTLKVWNVRTGKLSEDLPGHKDEVFAVDWSPDGQKVGSGGKDKAIRIWRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>C8VU64</accession>
    <name>C8VU64_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Exocyst complex component SEC5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ANIA_01002</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the exocyst complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the SEC5 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF88358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050469090.1">
        <property type="nucleotide sequence ID" value="XM_050613261.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VU64"/>
    <dbReference type="FunCoup" id="C8VU64">
        <property type="interactions" value="309"/>
    </dbReference>
    <dbReference type="STRING" id="227321.C8VU64"/>
    <dbReference type="GeneID" id="2876777"/>
    <dbReference type="KEGG" id="ani:ANIA_01002"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN1002"/>
    <dbReference type="eggNOG" id="KOG2347">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011308_0_0_1"/>
    <dbReference type="InParanoid" id="C8VU64"/>
    <dbReference type="OMA" id="RMWMDVD"/>
    <dbReference type="OrthoDB" id="26242at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029175">
        <property type="entry name" value="EXOC2/Sec5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039481">
        <property type="entry name" value="EXOC2/Sec5_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13043:SF1">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13043">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT SEC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15469">
        <property type="entry name" value="Sec5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex component EXOC2/Sec5 N-terminal" evidence="6">
        <location>
            <begin position="76"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="17"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="20"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU365069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF15469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBF88358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="1035" mass="115017" checksum="0D461CF2178F5477" modified="2009-11-03" version="1">MTDADIAHFYNLPSAYPDEWPAELDDEDEEEGEALQRRGSKSSYHVLDRSNSRRGPNLGSMKGNNSRENLVKVDEPDPLGSTSSVLNALKKRGLPVAEDSRLRNRFLLSSTGFSPALFLSQVHSDASIESLINGLNVLSQSIDQKSASLKVLVEANFERFVRAKATIDSVYTEMRNQGREQEQVAQRRSIGHVRSISGAKQGPLSSINSSKFRKNALLKESDYGVKGIWAPLTEASVKAEEVWGPALSGREREQMLKSVIDSMERRREVYEIGGHLSKSIKQKDYESVFEQYRKARALTQEAKNIADIAGSEGRPLTDEETYVILALGRMWIDVDQQIQGFKRDLWRRLSEAPSTSTRITTSGPIEEYMELIGALLELGVDDNPIWVWLLSRYDYLRAKIKAFCERGKVEIEILRRRLASGAEPTPQEVASYLRRTPQDSSTGPAHLPDTDQVIELWECVHTYLNRLLSSQGGILGEILDFWEVAQSFIDGNKQKLLPVGFEGESRKHHKFSSSDVRDLQKGLIELISLVREGVLSLFAEAPVEDVSLLTSPISPSSPSSPVSLGVTPTESRFKLDPKNIPFPTPKRGEPWEDYAFWPPFSNSLSGVNYLGQFLIIIGAAAGEMTTLEPVSSSSTSQELLRGLVSIIRERAVRISCSAWAKDAEVCRLLEDWTRDPKRRDLTKMPALFVNFQNAIVSGLQKILYMSEAMAKPGTVTVVTQPPTKLLQMVRREFISSIEKALGGLVETAEHPTTREENDEWSVSEATAVVRNSNGSSASLAADAVDSQNRNVRILLTLSNIKAFQMDLVPQLIANFEASFSVTLTDEAKLIRQVLDEVEQRLFRSYTEPTITNLKTIITEGVTSPTWEPTTSRPEQVRPYVYNALLALVLVHTEISTTIPSTSSSTSSRSAASSASGQSPLLTIVLTHLLTQVCTALVNAFNLRASYSLNALIQATLDTEFIAQTMSQYSSEEASAVQSQIYVELDQRTTHEARARLQSELGEMRGILKRLRERTKGEFACFRKPRSGTSQKSGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>C8VUX5</accession>
    <name>C8VUX5_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ATPase (Eurofung)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ANIA_10043</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF90013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050469303.1">
        <property type="nucleotide sequence ID" value="XM_050611032.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VUX5"/>
    <dbReference type="STRING" id="227321.C8VUX5"/>
    <dbReference type="GeneID" id="2875968"/>
    <dbReference type="KEGG" id="ani:ANIA_10043"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN10043"/>
    <dbReference type="eggNOG" id="KOG0385">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000315_32_1_1"/>
    <dbReference type="InParanoid" id="C8VUX5"/>
    <dbReference type="OMA" id="DINAAHD"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140750">
        <property type="term" value="F:nucleosome array spacer activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd17919">
        <property type="entry name" value="DEXHc_Snf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000115">
        <property type="entry name" value="Nucleosome remodeling complex ATPase subunit (Snf2h)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10799">
        <property type="entry name" value="SNF2/RAD54 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="4">
        <location>
            <begin position="2"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="5">
        <location>
            <begin position="338"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBF90013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="648" mass="74026" checksum="962D310E2855CB9D" modified="2009-11-03" version="1">MIYWRNNGIGGILADDMGLGKTLQALSLFQYVKDNERADSKFLVVCPLSVLNTWMSEISRWTTGLRPMAYHGGSEERENLRTCFRQQGAEPWNIVVTTYETLCSDLWFFQKTLWAHVVLDEGHRIKNSRSKRTQGVYRLRSENRIVLTGTPIQNDLTELWSILHWLYPDVFVPATAKLFENAFSLTDGKFDSIFLSHITRFLKVVMLRRTKCDSQIGLDLPPKKETVFSVPLTELQLGWYRTILTGVDESILLGSIEQEKSQSNVVPMTDSIVESMTAAWETNKATNTKRRSHITTNTLMELRKCSIHPYLLADALPKEYNIGQHIVDASCKFIVLQKMIRQYVGLENKKVIIFSGFDQTLDLCEDLLEMEKAQFSFKYGRLDGSTSSAWRNLSVFLFQNDPRYMVFLLSTRAGGEGLNLVSSSIVIFLDDDWNPQVMRQAESRVHRIGQTQPVQIFRIHAKGTVEDQMRRRMDKKAYLADKVMGEFGNNITHHTDLEETTEDEICLIPSRPIIPRSFDAKDLVNSDFHSIMSSYALDEVSIQGMSHAEKRAWLARSERVKTNIFNGVMVETKYRRFSVYDETVLSISKASRRIGKSRVVTVGEWKVSKESMEMATPVSPTFPKQGVGDKACKMNEAPALPEDFYSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-12-14" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G5EB84</accession>
    <accession>C8VK80</accession>
    <name>G5EB84_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GTP-binding protein EsdC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">esdC</name>
        <name evidence="2" type="ORF">ANIA_09121</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF82506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_682390.1">
        <property type="nucleotide sequence ID" value="XM_677298.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G5EB84"/>
    <dbReference type="STRING" id="227321.G5EB84"/>
    <dbReference type="GeneID" id="2867956"/>
    <dbReference type="KEGG" id="ani:ANIA_09121"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN9121"/>
    <dbReference type="eggNOG" id="ENOG502QVY6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063252_1_0_1"/>
    <dbReference type="InParanoid" id="G5EB84"/>
    <dbReference type="OMA" id="WDNYAGQ"/>
    <dbReference type="OrthoDB" id="5364946at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048315">
        <property type="term" value="P:conidium formation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0075308">
        <property type="term" value="P:negative regulation of conidium formation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043941">
        <property type="term" value="P:positive regulation of sexual sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043935">
        <property type="term" value="P:sexual sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000885">
        <property type="entry name" value="Putative GTP-binding protein EsdC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40625:SF2">
        <property type="entry name" value="GTP-BINDING PROTEIN ESDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40625">
        <property type="entry name" value="GTP-BINDING PROTEIN ESDC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="169"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF82506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="266" mass="29388" checksum="F58459AF4C7E2436" modified="2011-12-14" version="1">MSAVQLKFNLRTSSNVKTVHLLGSWDNYSRQIPLSRDSSKPGSWVGKFRFQTSMLKLGGRYWYYYILDGYHVSHDPAADYTVEPTTNRKLNILDVPGGKESSSSARRPRRGSSDIATGRALSPSKIHHPKPSKPYASRQIREADFAPTHAMDELSRRFGSSRLSDDGYSDLSNSPPSSVGSSLSSRSSGSTSPSSLSSMSDPPSVCHCERYGITRKGDRVKLDCGGSRCGYLSETSGDSCSEDSDSDEEYRRARRGVRRQGIVVRR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-06-21" modified="2025-06-18" version="118" xmlns="https://uniprot.org/uniprot">
    <accession>P78612</accession>
    <accession>C8VPQ7</accession>
    <accession>Q5BC86</accession>
    <name>PALF_EMENI</name>
    <protein>
        <recommendedName>
            <fullName>pH-response regulator protein palF/RIM8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">palF</name>
        <name type="ORF">AN1844</name>
    </gene>
    <organism>
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1997" name="Gene" volume="194" first="163" last="167">
            <title>The sequence of palF, an environmental pH response gene in Aspergillus nidulans.</title>
            <authorList>
                <person name="Maccheroni W. Jr."/>
                <person name="May G.S."/>
                <person name="Martinez-Rossi N.M."/>
                <person name="Rossi A."/>
            </authorList>
            <dbReference type="PubMed" id="9272857"/>
            <dbReference type="DOI" id="10.1016/S0378-1119(97)00095-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="1986" name="Mol. Gen. Genet." volume="203" first="346" last="353">
            <title>Regulation of gene expression by pH of the growth medium in Aspergillus nidulans.</title>
            <authorList>
                <person name="Caddick M.X."/>
                <person name="Brownlee A.G."/>
                <person name="Arst H.N. Jr."/>
            </authorList>
            <dbReference type="PubMed" id="3016485"/>
            <dbReference type="DOI" id="10.1007/BF00333978"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Required for the proteolytic cleavage of the transcription factor pacC in response to alkaline ambient pH.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the arrestin family. PalF/RIM8 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="U56696">
        <property type="protein sequence ID" value="AAC49808.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AACD01000029">
        <property type="protein sequence ID" value="EAA65009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF85673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_659448.1">
        <property type="nucleotide sequence ID" value="XM_654356.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P78612"/>
    <dbReference type="FunCoup" id="P78612">
        <property type="interactions" value="23"/>
    </dbReference>
    <dbReference type="STRING" id="227321.P78612"/>
    <dbReference type="EnsemblFungi" id="CBF85673">
        <property type="protein sequence ID" value="CBF85673"/>
        <property type="gene ID" value="ANIA_01844"/>
    </dbReference>
    <dbReference type="KEGG" id="ani:ANIA_01844"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN1844"/>
    <dbReference type="eggNOG" id="ENOG502QTQN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006001_0_0_1"/>
    <dbReference type="InParanoid" id="P78612"/>
    <dbReference type="OMA" id="CLHGYAK"/>
    <dbReference type="OrthoDB" id="7785529at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071467">
        <property type="term" value="P:cellular response to pH"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042318">
        <property type="term" value="P:penicillin biosynthetic process"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900198">
        <property type="term" value="P:positive regulation of penicillin biosynthetic process"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900376">
        <property type="term" value="P:regulation of secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070086">
        <property type="term" value="P:ubiquitin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF161">
        <property type="entry name" value="PH-RESPONSE REGULATOR PROTEIN PALF_RIM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02752">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01017">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000058189" description="pH-response regulator protein palF/RIM8">
        <location>
            <begin position="1"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="531"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="586"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="631"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="697"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="262"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="697"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="710"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="733"/>
            <end position="743"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="3016485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="775" mass="84087" checksum="92D458A986F98B58" modified="1997-05-01" version="1">MVRATCSCVMSVNPLSAQTSASPLSRNRSSLLSKFRTQLGQRNRAITDFYIEPDDPWRSYFPGDVIKGTVSLTVVRPVRITHLVISLHGIVKVFKNNVPAGETPPDVGSLGPGRGRRGAEYLGNGVATLFEDEVVLCGEGRLKEGIYKFRFEMSFPPYPLPSSISFERGTISYMLTSTLTKPTTMNPTLSCRRRINLLENIDIAAFPAPKPRVVTLEPISKRSKPKGKTKAAGFDAPDTASLEPSASGGITVPEHRPPLSPAPSNVSSSSRLSNSSQSFQIVTDPGSTASSGVRNSEARSNTPSVTDGIITAKAEVLRAGVLPGDTLPIKITINHTKQVRSAHGIIITLYRSGRIDLHPAIPMGSTANGKKPIYEDYYPRSRTGLGGLTLGTSRASSVFRKDLSQTFAPLIVDPTTLTADIKTSIRIPEDAFPTITRTPGSMINFRYYVEVVVDLRGKLTSPERFLPRFNLVSSGRNFSSNGKIVHPADTNGSAITANWGDNILDTDQIRREKGVVAVIFEVVIGTQDTQRRKSEARRMSSTAEEAEFQQPVENSVDGDYAGHDYQGSMAGPEPGYAPLENTAYGPDQIRWPDYPEQSEHEHYPFQPGTLPSPQPDEPMDEKARLRRAEQTLLPSQPPCDPEAGPSSAVEAAMPTAPVLPEDDHLNDYHHLPSTTVNGMTGMAPALMSAESVQTVIAGSSSAPLTSPSRPSEEDKQELERQRLMMEASAPGDPDARHNDRADDGPSAPIFHDDDDDQQLVGGAANGDELLPRYQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AQD2</accession>
    <accession>C8V0Q8</accession>
    <name>Q5AQD2_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tetratricopeptide repeat protein 1 (TTC1), putative (AFU_orthologue AFUA_6G10770)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_09498</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF69583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_868880.1">
        <property type="nucleotide sequence ID" value="XM_863787.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AQD2"/>
    <dbReference type="STRING" id="227321.Q5AQD2"/>
    <dbReference type="GeneID" id="3684097"/>
    <dbReference type="KEGG" id="ani:ANIA_09498"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN9498"/>
    <dbReference type="eggNOG" id="KOG4234">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058463_1_0_1"/>
    <dbReference type="InParanoid" id="Q5AQD2"/>
    <dbReference type="OMA" id="KSAIDDC"/>
    <dbReference type="OrthoDB" id="1872379at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052769">
        <property type="entry name" value="TPR_domain_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46014">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46014:SF1">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF69583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="275" mass="30158" checksum="27BBE2495555FC12" modified="2005-04-26" version="1">MPPDTSSASNGRDLTNHAGSDTENEDEVFHDARFPPEEETRLLAESHSLKAEANNLYSAASYSQAISTYDRALASCPSYLDYEIAVVRSNMSACYLKLGDWKAAVDSANACIEGLDRVVPPSQPEDGKEGAAKEADSVVEIPVDDEVNEQAALQRIKENDERKRDVARIRAKALMRRARAKSELGGWANLQGAEEDYKLLAGMENLPPSDRKVVQKALRELPARISKAKEVEMGEMMGKLKELGNGILKPFGLSTDNFKFVQDPKTGGYSVNFSS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-03-07" modified="2026-01-28" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AQJ2</accession>
    <accession>C8VRB1</accession>
    <name>LCMT1_EMENI</name>
    <protein>
        <recommendedName>
            <fullName>Leucine carboxyl methyltransferase 1</fullName>
            <ecNumber>2.1.1.233</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Protein phosphatase methyltransferase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>[Phosphatase 2A protein]-leucine-carboxy methyltransferase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">ppm1</name>
        <name type="ORF">AN9438</name>
    </gene>
    <organism>
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha-leucine ester residues.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>[phosphatase 2A protein]-C-terminal L-leucine + S-adenosyl-L-methionine = [phosphatase 2A protein]-C-terminal L-leucine methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:48544"/>
            <dbReference type="Rhea" id="RHEA-COMP:12134"/>
            <dbReference type="Rhea" id="RHEA-COMP:12135"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90516"/>
            <dbReference type="ChEBI" id="CHEBI:90517"/>
            <dbReference type="EC" id="2.1.1.233"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the methyltransferase superfamily. LCMT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.233"/>
    <dbReference type="EMBL" id="AACD01000180">
        <property type="protein sequence ID" value="EAA66818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF88905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AQJ2"/>
    <dbReference type="SMR" id="Q5AQJ2"/>
    <dbReference type="FunCoup" id="Q5AQJ2">
        <property type="interactions" value="528"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5AQJ2"/>
    <dbReference type="EnsemblFungi" id="CBF88905">
        <property type="protein sequence ID" value="CBF88905"/>
        <property type="gene ID" value="ANIA_09438"/>
    </dbReference>
    <dbReference type="GeneID" id="3684031"/>
    <dbReference type="KEGG" id="ani:ANIA_09438"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN9438"/>
    <dbReference type="eggNOG" id="KOG2918">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031312_1_1_1"/>
    <dbReference type="InParanoid" id="Q5AQJ2"/>
    <dbReference type="OMA" id="IIYEPIR"/>
    <dbReference type="OrthoDB" id="203237at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018423">
        <property type="term" value="F:protein C-terminal leucine carboxyl O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000369">
        <property type="entry name" value="Leucine carboxyl methyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016651">
        <property type="entry name" value="LCMT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007213">
        <property type="entry name" value="Ppm1/Ppm2/Tcmp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13600">
        <property type="entry name" value="LEUCINE CARBOXYL METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13600:SF21">
        <property type="entry name" value="LEUCINE CARBOXYL METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04072">
        <property type="entry name" value="LCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016305">
        <property type="entry name" value="LCM_mtfrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000226128" description="Leucine carboxyl methyltransferase 1">
        <location>
            <begin position="1"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="193"/>
            <end position="194"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; EAA66818." evidence="3" ref="1">
        <original>K</original>
        <variation>D</variation>
        <location>
            <position position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="382" mass="42319" checksum="281E704F0BB6BFFA" modified="2011-11-16" version="2">MSAPQIPNLNTLRRGGGRGRFRARGGPDSSSSSGNKDRVVQGTDNDASVSRLSAVELGYLEDPFARALTPMGQEMRRLPIINRGTYVRTTAIDQLVASFLGLKADSDPTWKLKKKQIISLGAGSDTRVFRLLSLRPALDIIYHEIDFAVNNTAKIKAIQGTPLLQRVLGQSQVSISNEGDELHSPAYHIHAVDLRTLAQKGEGDKSTGQDPGRRLQDFVDTTLPTLLLSECCLIYLSPNDAAGVVRYFTHTLFPASQETETLALVLYEPIRPDDAFGRTMVANLATRGIQLQTLHQYASLGAQRQRLREHGFNGGQAAADVDFLWERWVAEEEKERVAALEMLDEVEEWKLLAQHYCVAWGWRKGSTRFTGWGDLDGQSAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ARG3</accession>
    <accession>C8VK84</accession>
    <name>Q5ARG3_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Miscellaneous Zn(II)2Cys6 transcription factor (Eurofung)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ANIA_09117</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF82513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_677294.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ARG3"/>
    <dbReference type="GeneID" id="2867955"/>
    <dbReference type="KEGG" id="ani:ANIA_09117"/>
    <dbReference type="eggNOG" id="ENOG502RHAD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006329_2_1_1"/>
    <dbReference type="InParanoid" id="Q5ARG3"/>
    <dbReference type="OMA" id="LMTYWSD"/>
    <dbReference type="OrthoDB" id="4451586at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Fungal_Detox/Toxin_TFs"/>
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    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47425">
        <property type="entry name" value="FARB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47425:SF1">
        <property type="entry name" value="MISCELLANEOUS ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="3">
        <location>
            <begin position="234"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
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        <location>
            <begin position="565"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="744"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="617"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="652"/>
            <end position="679"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBF82513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="790" mass="88319" checksum="ED904FD8DE3F4E31" modified="2005-04-26" version="1">MLNAKRKQSEAGLTDDGPARRRSSNILGYNAQTPWLHESHDSRFSAIRRSIGTRGHAASLPLANMVSTVQDLIDPDFDPLIAILDEEPRFLKPLPSRISAEDLEFLRFRGALAIPESGLRIELLRCYIKWVHSFLPVLNLQEFLRCVALNDPEGNISLLLFQAVMFVATAFVDLKHLQAAGYTTRKSARNAFYTRLRIQLLYSLDCEEDRLVIVQTLLLMTYWSDHMNNPQRDIWDWIGICSTNAHSIGLNRDPSSSDLDIRTKRLRTRLWWCLFSRDRLIAMGMRRPTQVNEGSSNLPMLRLDDFDFEPFHPAVIEQFQCRQLEDVSHQKRLATMFIEKAKLCQCIGRVLFAQYTPSQCQFGLTNRTTINLVPRHASESELARCSQRLESWLSALPRDAQFVPASKTIFNDGEDVLLLHGAMIRMLYHATVSALHRPWAYGSTKDQTKSRLELAAAARTKMQDAAIGITQIIQGLNQLDLTRYLPQSGVTVILPAAVAHLANSMSNDPTLRENSISNFQRCIRVLQGLKEIYPAADMEVANIEAAVKAQSNTSALLRIMQFNGSLPSRPGSPHRTSLVSNPARIPSPLDEPNHWTPPADEQDTAHPILHQLGHASPDNKDKRSSPLKPNHEHSAQSNPPRQDQPTPPTDIPDPVTISPTTPQQNQNQPPVNPPKSSIFTDLLDFDLDTYTSTFTPSNPNPAAGPDLDLDWTSELLRWADANPEYYSAPNTNNDQRDIFSFPVGPGPGHNPTDLGLGNDGGSRGHGNLSSEITGDLDRDLGFTGDGEELF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ART6</accession>
    <accession>C8VL08</accession>
    <name>Q5ART6_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ANIA_08994</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF84499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_682263.1">
        <property type="nucleotide sequence ID" value="XM_677171.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ART6"/>
    <dbReference type="STRING" id="227321.Q5ART6"/>
    <dbReference type="GeneID" id="2868304"/>
    <dbReference type="KEGG" id="ani:ANIA_08994"/>
    <dbReference type="eggNOG" id="ENOG502S1QQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070836_0_0_1"/>
    <dbReference type="InParanoid" id="Q5ART6"/>
    <dbReference type="OMA" id="FTIYATI"/>
    <dbReference type="OrthoDB" id="58379at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38696">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38696:SF1">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF84499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="290" mass="31617" checksum="5C4EA2A1E3819C6A" modified="2005-04-26" version="1">MHYDQPPAYTETTLTAASLVGPALDRPSSSHSSTASIPSVSISLSNTTATETSPKGGDASSSFAMLSLGDSDKLRFIRFPDHLIVIASEVITRLWPKGIQKTQNFDESVQFKLKGNPLGYSFDGEKAAIRVTIMGLLNAFAKEGWVVLPAGKVGKMGRGDSQSYGQGDSLVFHRQHPESRSWLCVSFDSADLLHLLNAPAELTTLLLASFGDRIEKCNKDFVSGNFELKFKGSPWTKTGAKGAVQCRLILLDLMQCFEEHGYTMCTALDIDGGLGGTEYKSNGEAWFWYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ARX9</accession>
    <accession>C8VLA5</accession>
    <name>Q5ARX9_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ANIA_08951</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF84585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_682220.1">
        <property type="nucleotide sequence ID" value="XM_677128.1"/>
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    <dbReference type="AlphaFoldDB" id="Q5ARX9"/>
    <dbReference type="GeneID" id="2868248"/>
    <dbReference type="KEGG" id="ani:ANIA_08951"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN8951"/>
    <dbReference type="eggNOG" id="ENOG502RZDV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028200_8_0_1"/>
    <dbReference type="InParanoid" id="Q5ARX9"/>
    <dbReference type="OMA" id="MTIICDS"/>
    <dbReference type="OrthoDB" id="5283415at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF129">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="18"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="93"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="198"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="236"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="35"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="267"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="270"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBF84585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="357" mass="39082" checksum="0ED0BD0AE472A461" modified="2005-04-26" version="1">MASEPSAAYLAEDRSQPALIGIVVVTALSAVVVIVRLYARRVLVRGLGWDDLFIVLAQLVSWATMALCSQILRYGSGRHLVALLKTPETLVRMYKWLVTTQMVYMFNLWLCRVSGLTFYARLNPMPRFILYLRLSFAFVTAVWAAQSLIIALQCIPLEALWDNSITDKKCMGSAMVFISTGALTIIVMGLQAKTARKLALLGILCFGVLTSILRMVSMIVSVQHEDDATWYFSPVVAWTCAEISAAIIALSLPALRAIFGFLKEHHSTRGKSNSYPNTGSGSKGIGLDSLSKSATKQPKVFHGSGVYDNTVDIGVGRSPSQEVLWNGYGDRSYGNRGNGSPREIMITETVDVEVGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ASZ6</accession>
    <accession>C8VAJ0</accession>
    <name>Q5ASZ6_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Stress-response A/B barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_08584</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF78392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_681853.1">
        <property type="nucleotide sequence ID" value="XM_676761.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ASZ6"/>
    <dbReference type="GeneID" id="2868488"/>
    <dbReference type="KEGG" id="ani:ANIA_08584"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN8584"/>
    <dbReference type="eggNOG" id="ENOG502S73V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080664_2_1_1"/>
    <dbReference type="InParanoid" id="Q5ASZ6"/>
    <dbReference type="OMA" id="MTITHIV"/>
    <dbReference type="OrthoDB" id="1601230at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013097">
        <property type="entry name" value="Dabb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044662">
        <property type="entry name" value="HS1/DABB1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33178">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33178:SF10">
        <property type="entry name" value="STRESS-RESPONSE A_B BARREL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07876">
        <property type="entry name" value="Dabb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00886">
        <property type="entry name" value="Dabb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51502">
        <property type="entry name" value="S_R_A_B_BARREL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Stress-response A/B barrel" evidence="2">
        <location>
            <begin position="3"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF78392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="111" mass="12592" checksum="1C8A68C31D2234B5" modified="2005-04-26" version="1">MSVTHIVVFRFKDGTSDEKIEEVCREVVALKEKCILPRTQKPYIKSYVGGKDHSPEGAQHGMTHAFVAQFESREDRDYYVSKDPVHLELGPRIAPVVETFLCLDFTPGLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ATB5</accession>
    <accession>C8VEH7</accession>
    <name>Q5ATB5_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">alpha-L-rhamnosidase</fullName>
            <ecNumber evidence="2">3.2.1.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ANIA_08465</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing alpha-L-rhamnose residues in alpha-L-rhamnosides.</text>
            <dbReference type="EC" id="3.2.1.40"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.2.1.40" evidence="2"/>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF80608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_681734.1">
        <property type="nucleotide sequence ID" value="XM_676642.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ATB5"/>
    <dbReference type="SMR" id="Q5ATB5"/>
    <dbReference type="CAZy" id="GH78">
        <property type="family name" value="Glycoside Hydrolase Family 78"/>
    </dbReference>
    <dbReference type="GeneID" id="2868870"/>
    <dbReference type="KEGG" id="ani:ANIA_08465"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN8465"/>
    <dbReference type="eggNOG" id="ENOG502SHCX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002926_1_1_1"/>
    <dbReference type="InParanoid" id="Q5ATB5"/>
    <dbReference type="OMA" id="CFTSARY"/>
    <dbReference type="OrthoDB" id="10036721at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030596">
        <property type="term" value="F:alpha-L-rhamnosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.420.10">
        <property type="entry name" value="Maltose phosphorylase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016007">
        <property type="entry name" value="Alpha_rhamnosid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035396">
        <property type="entry name" value="Bac_rhamnosid6H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035398">
        <property type="entry name" value="Bac_rhamnosid_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013737">
        <property type="entry name" value="Bac_rhamnosid_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008902">
        <property type="entry name" value="Rhamnosid_concanavalin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33307:SF11">
        <property type="entry name" value="ALPHA-L-RHAMNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33307">
        <property type="entry name" value="ALPHA-RHAMNOSIDASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05592">
        <property type="entry name" value="Bac_rhamnosid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17389">
        <property type="entry name" value="Bac_rhamnosid6H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17390">
        <property type="entry name" value="Bac_rhamnosid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08531">
        <property type="entry name" value="Bac_rhamnosid_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25788">
        <property type="entry name" value="Ig_Rha78A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bacterial alpha-L-rhamnosidase N-terminal" evidence="5">
        <location>
            <begin position="170"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-L-rhamnosidase concanavalin-like" evidence="4">
        <location>
            <begin position="357"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-L-rhamnosidase six-hairpin glycosidase" evidence="6">
        <location>
            <begin position="470"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-L-rhamnosidase C-terminal" evidence="7">
        <location>
            <begin position="816"/>
            <end position="891"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBF80608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="914" mass="103711" checksum="3D5B2734E39A6206" modified="2005-04-26" version="1">MEVTRCGIHGFHETLGIDTDEIRFFWVLEGGCSRSEQTAYRIAVSSEKKGLEEQPDAWDSGRVESDAQRNIICKPESGFKSTTTYYWQVTVWDQEGKESKSAVNDFYTSYPRSSRLLPPYSMNQTYMPHTNLIFRTWFENEADRWKAVWIGNGGDKPIYLRKSIQLSSAKRVEKVVIFASGLGHFNLFVNGKPASTHVLDPGWTNYHRTVQFVGYNVTPQWSEKENVIGAHVGNGFYAGDQGDRFFWPMYEDNTYVRYGNELCFFAEIHVHYDDGSHETIISDPSWKVRKSATTLANIYASEDHDRRGYPFGWDTPGYDDSTWASAKPLTGPRGKLRYQSQPPVILHNLFTPVKHKQLRPGVTMFDLGQNSSIMPRVEVSGPAGSEIIIRYSETVDDVGSVFMPDPLFKEFEYGVYSKLILSGTGVEIWTPDFSFTSARYIQIEGASLDETDNLPTIHSVSARHISSAARQLGYVKTDRKDVNDLINACYWTFSSNIFSYHTDCPQIEKFGWLEVTSLLAPATQYVRDMEAVYSKILDDIIDTQESNGLVPTMAPEIRYMCGPLHDTITWGCAIAFLPELIKRYYGSTEVFGKIYQPCIRYMEYMKTKERQGGLIEHGLGDWGRDIAFGNHQANIETAVYYRCLRNVALMAKELGQADDEAKFTAWAERIYAVYNKHLLINDKASRPYAFYTSLDNPGTYDCTMVAQAVALQFGLVPVEHRAEVIKAFLSACEASGNRIEAGEIGLKYLWNTLAEPDVDRPDIVLAMARQEEHPSYMRFLRRGETTLLEFWQDACRSKCHDMLGTIYEWFYEAVLGVKPVGDAYKTWTLRPPFVSEFGLVEGEVDCPYGLIKVRFERGESGKVRLDVRIPTSTNCRLVLPVGARVVAGLPTKVRVSSKSEIHLPQGEHQLVVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ATG1</accession>
    <accession>C8VEC2</accession>
    <name>Q5ATG1_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_08419</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF80504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_681688.1">
        <property type="nucleotide sequence ID" value="XM_676596.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ATG1"/>
    <dbReference type="STRING" id="227321.Q5ATG1"/>
    <dbReference type="GeneID" id="2868636"/>
    <dbReference type="KEGG" id="ani:ANIA_08419"/>
    <dbReference type="eggNOG" id="ENOG502SKT5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059206_3_1_1"/>
    <dbReference type="InParanoid" id="Q5ATG1"/>
    <dbReference type="OMA" id="REMWPAD"/>
    <dbReference type="OrthoDB" id="5131368at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018713">
        <property type="entry name" value="MPAB/Lcp_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36151">
        <property type="entry name" value="BLR2777 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36151:SF3">
        <property type="entry name" value="ER-BOUND OXYGENASE MPAB_MPAB'_RUBBER OXYGENASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09995">
        <property type="entry name" value="MPAB_Lcp_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic" evidence="1">
        <location>
            <begin position="35"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF80504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="304" mass="33560" checksum="669BF8B250399B48" modified="2005-04-26" version="1">MASISPKEARSVVITIDDDATPLGETDLAIRELQAVAKEGVALGAGLAAILLQIAHPLVGQGVADHSTFASRTISRTQYTQMYIFTMIFGSDEEKAAMKKWVDEAHSRVKGEVASGQRKSEAYDAMNPELQLWVAATIYASMVGMYEKVYGELPPLKAELVYQAFACMGTSLQVPREMWPADRRAFKTYWEDVVTNQLEVTADARGVLNELFHPKGLPLWAKPFAWMLLPIVRPVTIEQLPPNVREGFGLKSTRRTRAVTALFMSTVAALAEELFLKVAEEENEEAGREAGKVVASSRGYTRAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ATL3</accession>
    <accession>C8VE62</accession>
    <name>Q5ATL3_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cell surface protein, putative (AFU_orthologue AFUA_4G14085)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ANIA_08367</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF80396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_681636.1">
        <property type="nucleotide sequence ID" value="XM_676544.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ATL3"/>
    <dbReference type="STRING" id="227321.Q5ATL3"/>
    <dbReference type="GeneID" id="2868679"/>
    <dbReference type="KEGG" id="ani:ANIA_08367"/>
    <dbReference type="eggNOG" id="ENOG502SJYE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060605_0_0_1"/>
    <dbReference type="InParanoid" id="Q5ATL3"/>
    <dbReference type="OMA" id="TTWAPLY"/>
    <dbReference type="OrthoDB" id="5342184at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021986">
        <property type="entry name" value="Spherulin4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35040:SF8">
        <property type="entry name" value="SURFACE PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14085)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12138">
        <property type="entry name" value="Spherulin4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF80396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="260" mass="29464" checksum="9DB0809EA855442A" modified="2005-04-26" version="1">MQAQKSAVKSAVVVPLYIYPLSAESWAPLYAAIETNPTLTFLVIVNPNSGPGLPEHPSPDASYSQQVPRLNAYRNVLTIGYIRVDYCRKPLQEALAEIARYASWSEHYETTGLGVRGIFVDETPNHYSREKEEYLRSITSFVKECPGILDEKLIAHNPGTPPDVRLAQPAEVTFVCEESYARFRSDEVQNWLAAHPVDRDRAGYMISGVPVDELPQLVRDLRTRAAWLFVTDVKENFYERFSDAWRDGTFIRALHGKNQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="116" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AU05</accession>
    <accession>C8V7E5</accession>
    <name>Q5AU05_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Mitochondrial large ribosomal subunit protein L1, putative (AFU_orthologue AFUA_5G03570)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ANIA_08225</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL1 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF74149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_681494.1">
        <property type="nucleotide sequence ID" value="XM_676402.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AU05"/>
    <dbReference type="FunCoup" id="Q5AU05">
        <property type="interactions" value="249"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5AU05"/>
    <dbReference type="GeneID" id="2868991"/>
    <dbReference type="KEGG" id="ani:ANIA_08225"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN8225"/>
    <dbReference type="eggNOG" id="KOG1569">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062853_1_0_1"/>
    <dbReference type="InParanoid" id="Q5AU05"/>
    <dbReference type="OMA" id="EFRVDKH"/>
    <dbReference type="OrthoDB" id="1747252at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00403">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.790:FF:000001">
        <property type="entry name" value="50S ribosomal protein L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023674">
        <property type="entry name" value="Ribosomal_uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028364">
        <property type="entry name" value="Ribosomal_uL1/biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016095">
        <property type="entry name" value="Ribosomal_uL1_3-a/b-sand"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36427">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36427:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL1M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00687">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56808">
        <property type="entry name" value="Ribosomal protein L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="45"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="57"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBF74149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="310" mass="33943" checksum="14272F8F1F6D043C" modified="2005-04-26" version="1">MSSFSALMPTGARALLSICRPSIRQGSMAAPLFFGYQQAQARGAATARNKQAAERRKRDKAAKSAKSKKGPREFKQKDLKDVEQFALCDAMRYLRAFEVGREPAVSKYEVHIRLKTRRDGPVIRNMIRFPHSVQTESRICVICPPGSKHAKDALAAGAVLVGEDEVFEVVKSGRIEFDRCLAHPDSMPALAKAGLGRILGPRGLMPSAKTGTVVEDVAARVEMLRGGTVYRERDAVVRLPIGQLGFSPEQLRDNLRVTIDQVKKDAASLNDRITKEIYEVVLSSTHGPGFSLNGEFKTENSVDPALLTGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="134" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AU19</accession>
    <accession>C8V776</accession>
    <name>Q5AU19_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">PHD transcription factor (Rum1), putative (AFU_orthologue AFUA_5G03430)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">ANIA_08211</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF74118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_681480.1">
        <property type="nucleotide sequence ID" value="XM_676388.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q5AU19">
        <property type="interactions" value="329"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5AU19"/>
    <dbReference type="GeneID" id="2869040"/>
    <dbReference type="KEGG" id="ani:ANIA_08211"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN8211"/>
    <dbReference type="eggNOG" id="KOG1246">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000991_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AU19"/>
    <dbReference type="OMA" id="GFDQVCK"/>
    <dbReference type="OrthoDB" id="1678912at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034647">
        <property type="term" value="F:histone H3K4me/H3K4me2/H3K4me3 demethylase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd16100">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15518">
        <property type="entry name" value="PHD_Ecm5p_Lid2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15543">
        <property type="entry name" value="PHD_RSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.60:FF:000010">
        <property type="entry name" value="PHD transcription factor (Rum1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.650:FF:000014">
        <property type="entry name" value="PHD transcription factor (Rum1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000322">
        <property type="entry name" value="PHD transcription factor (Rum1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:001029">
        <property type="entry name" value="PHD transcription factor (Rum1), putative (AFU_orthologue AFUA_5G03430)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.650:FF:000035">
        <property type="entry name" value="PHD transcription factor Rum1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.60">
        <property type="entry name" value="ARID DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001606">
        <property type="entry name" value="ARID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036431">
        <property type="entry name" value="ARID_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003349">
        <property type="entry name" value="JmjN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013637">
        <property type="entry name" value="Lys_sp_deMease-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004198">
        <property type="entry name" value="Znf_C5HC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10694">
        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10694:SF33">
        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01388">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02373">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF02375">
        <property type="entry name" value="JmjN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08429">
        <property type="entry name" value="PLU-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02928">
        <property type="entry name" value="zf-C5HC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01014">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00501">
        <property type="entry name" value="BRIGHT"/>
        <property type="match status" value="1"/>
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    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00545">
        <property type="entry name" value="JmjN"/>
        <property type="match status" value="1"/>
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    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="ARID-like"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FYVE/PHD zinc finger"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS51011">
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        <property type="match status" value="1"/>
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    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
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        <property type="entry name" value="JMJN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="JmjN" evidence="12">
        <location>
            <begin position="75"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="ARID" evidence="11">
        <location>
            <begin position="163"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="10">
        <location>
            <begin position="454"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="JmjC" evidence="13">
        <location>
            <begin position="596"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="10">
        <location>
            <begin position="1321"/>
            <end position="1370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="268"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="360"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1467"/>
            <end position="1560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1594"/>
            <end position="1717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="15"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="28"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="275"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="303"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="363"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="375"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1522"/>
            <end position="1546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="1656"/>
            <end position="1666"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CBF74118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="1717" mass="193117" checksum="004A2D193513586F" modified="2005-04-26" version="1">MVAPAAMGGPSIGTQPPASRQPARSSSTHPSHSHNVPLSTRRSAPLDLSTVERRGQPTAPREPTSRVRPHGLQEAPTFRPTEEEFRDPEAYIRKIAPEGKKYGICRIIPPENWQPTFAIDTEKFHFKTRRQELNSVEGGMPPRSALLAAGGTPQLSSNPDPGTRANLNYLDQLAKFHKQHGTNLNRFPSVDKRPLDLFRLKKAVEVRGGFEQVCKMKKWAEIGRDLGYSGKIMSSLSTSLKNSYQRWLQPYEEYLRVAKPGVQQQLEMEHGGPYTPSPNHSPMPKNPTPLEAETRSATPHGPSAASQSAPHDAAATPAKNSTPLVDPTPPRPIASGFTPVNAGGFTAVNKSPSFIAVNSAPAMKRDPDHEIATPKSVSEYQKDSTPVSNGHGSVKRAISTESGSQADTGELDANGRRSKRLKKDTPLPTVAGSQMTLLRPAPSRSRKSDARKFGDKCETCGKSEDRSSILVCDSCDQGFHRYCLDPPLHHIPEFDWHCPKCLVGTGEFGFEEGGVYSLKQFQEKANNFKKNYFASKMPFDPVLNTRRRESEDDVEREFWRLVESLTETVEVEYGADIHSTTHGSGFPTVERNPLDPYSKDPWNLNNLPFHGESLFRHIKSDISGMTVPWVYVGMCFSTFCWHNEDHYAYSANYQHFGATKTWYGIPGADAEAFEEAMRQAVPELFEGQPDLLFQLVTLMPPDQLRKAGVNVYALDQRAGQFVITFPQAYHAGFNHGFNFNEAVNFAPVDWEPFGAAGVERLQAFRRHPCFSHDELLFTAAARDTSISTAKWLAPALQRTCSRELAERASFAKRHQEATPHNCALLTDDSAPTGECQLGFLIEDKDLPEEDYQCHYCKAYIFLTQFKCHKSGKTLCLVHLDAHDCCGEPLSKKLLGPDHTLRYRVSDTELKSMVLKVQERSRIPEAWGQKLDNILEDDPKPQLKVLHNLLNEGEKIPYHLPGLQELAAFVQRCDKWVEEATNYITRKQQNRRKNEKAWRKTTSKASQLEERDREVRRVENIYALLAEADKLSFDCPQMAALEEKTREIEKFRLDVSAALANPHTRSIQEVEELVENSRNFNVDLPEVEDLEHIVRQMKWNEDAGRRRGQYLTLKDCQELILAGEQLGLSEANEHLAHFKDLCRHGEAWEAKAKELMSVEAVHYQQLEALSAQANRVPVSPETLAAVDAILTKQREAQKRIQSLYERSKDPDYKKRPLYKEVRELMESLEELNSRPTGAIDLEREQKRHEDWMRKGKKLFGKANAPLHILKSHMEYVEKRNFYCFDLEDRFRPPVEPASRDNSPDGQGGDVQQYYGQSTAKRDVFCICRHSEAGMMIECEICGEWYHGKCLKIARGKVKECDKYTCPICDWRQKIPRDAARPKLEDLQEWQSEIPSLPFQPDEEQILERIINQATAFREFLQRYTNTACTTTEEVPTLVFYLRKIEGAEVLLAYETNLFRQEIHKWQPVAPEPPPILEQSLSTRKPRPTKQQKLMARMGIQSPEDLPPHLRPKQTNPAKRKSIDTQASRPPTMQPASQTSGDNTSTDSRIGPTLAPNDAQSAPYPFSANYPLPASDTASAFAPEASAFLPHVSADSASFPPRSPTPPHGLPSSLFSPPRYSRTATGGPSGIDIDHSNPFGSSPRNLDDVFADLTNQDADPEPEQDPEPMENTHANEALELLDVGNDRESSVPVPDVEVENRPQEVNGQPEPEVEATAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="114" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AU26</accession>
    <accession>C8V769</accession>
    <name>Q5AU26_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD(+) diphosphatase</fullName>
            <ecNumber evidence="4">3.6.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ANIA_08204</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 5'-end NAD(+)-phospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-adenosine-phospho-ribonucleoside in mRNA + beta-nicotinamide D-ribonucleotide + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60876"/>
            <dbReference type="Rhea" id="RHEA-COMP:15698"/>
            <dbReference type="Rhea" id="RHEA-COMP:15719"/>
            <dbReference type="ChEBI" id="CHEBI:14649"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:144029"/>
            <dbReference type="ChEBI" id="CHEBI:144051"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:60877"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Nudix hydrolase family. NudC subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.22" evidence="4"/>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF74104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_681473.1">
        <property type="nucleotide sequence ID" value="XM_676381.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AU26"/>
    <dbReference type="FunCoup" id="Q5AU26">
        <property type="interactions" value="98"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5AU26"/>
    <dbReference type="GeneID" id="2868943"/>
    <dbReference type="KEGG" id="ani:ANIA_08204"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN8204"/>
    <dbReference type="eggNOG" id="KOG3084">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037162_0_2_1"/>
    <dbReference type="InParanoid" id="Q5AU26"/>
    <dbReference type="OMA" id="CNTRTTL"/>
    <dbReference type="OrthoDB" id="10249612at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035529">
        <property type="term" value="F:NADH pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019677">
        <property type="term" value="P:NAD+ catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006742">
        <property type="term" value="P:NADP+ catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd03429">
        <property type="entry name" value="NUDIX_NADH_pyrophosphatase_Nudt13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.20:FF:000005">
        <property type="entry name" value="NADH pyrophosphatase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000042">
        <property type="entry name" value="Probable NADH pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050241">
        <property type="entry name" value="NAD-cap_RNA_hydrolase_NudC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015375">
        <property type="entry name" value="NADH_PPase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049734">
        <property type="entry name" value="NudC-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42904:SF6">
        <property type="entry name" value="NAD-CAPPED RNA HYDROLASE NUDT12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42904">
        <property type="entry name" value="NUDIX HYDROLASE, NUDC SUBFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09296">
        <property type="entry name" value="NUDIX-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="10">
        <location>
            <begin position="251"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CBF74104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="415" mass="46131" checksum="8A36E7192F326666" modified="2005-04-26" version="1">MSNNSQIPNPAHIQADSMLARRFGKETVNYFSSSPLNRLSFLRSDHPFLSAAFKHPSTRFVILKDLAPLTRSPTELYYAKYDEVRKLLPASIYDKSEEEIIKEHDSRKTEPHLIFLGVDETDKQQDGFSWKIYSGTPYFALDVSEKGSEEQQHNAKEVVNGFEAQGLSFLQARVAMTFSANEAAIYAQARALIDWNTRNSYCGTCGSRTISVNSGTKRACPPTDAARVAEGKPAEKPACSTRTTISNLSFPRTDPTIIVAVISSDAKRILLGRSKRFPPNWYSTLAGFIEPAESVEDAVRREVWEEAGVTLSRVIIHSTQPWPYPANLMIGAIAQVSDPAHEKINLEHDPELEDARWFEIEEVEEALRVGTSNLDQAAGPGYKEGSLRLPPPTAIANQLIQAAINIDFLADKSKM</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-12-20" modified="2026-01-28" version="124" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AUJ1</accession>
    <accession>C8V603</accession>
    <name>H2AZ_EMENI</name>
    <protein>
        <recommendedName>
            <fullName>Histone H2A.Z</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">htz1</name>
        <name type="ORF">AN8039</name>
    </gene>
    <organism>
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Variant histone H2A which can replace H2A in some nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. This variant is enriched at promoters, it may keep them in a repressed state until the appropriate activation signal is received. Near telomeres, it may counteract gene silencing caused by the spread of heterochromatin proteins. Required for the RNA polymerase II and spt15/TBP recruitment to the target genes. Involved in chromosome stability.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. H2A or its variant H2A.Z forms a heterodimer with H2B. H2A.Z associates with the vps72/swc2 subunit of the SWR1 chromatin remodeling complex. Also interacts with rbp1/DNA-directed RNA polymerase II largest subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="1">Acetylated once deposited into chromatin.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the histone H2A family.</text>
    </comment>
    <dbReference type="EMBL" id="AACD01000139">
        <property type="protein sequence ID" value="EAA59661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF73756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_681308.1">
        <property type="nucleotide sequence ID" value="XM_676216.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AUJ1"/>
    <dbReference type="SMR" id="Q5AUJ1"/>
    <dbReference type="FunCoup" id="Q5AUJ1">
        <property type="interactions" value="1010"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5AUJ1"/>
    <dbReference type="EnsemblFungi" id="CBF73756">
        <property type="protein sequence ID" value="CBF73756"/>
        <property type="gene ID" value="ANIA_08039"/>
    </dbReference>
    <dbReference type="GeneID" id="2869194"/>
    <dbReference type="KEGG" id="ani:ANIA_08039"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN8039"/>
    <dbReference type="eggNOG" id="KOG1757">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062828_2_1_1"/>
    <dbReference type="InParanoid" id="Q5AUJ1"/>
    <dbReference type="OMA" id="MNKKGAP"/>
    <dbReference type="OrthoDB" id="9421954at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000791">
        <property type="term" value="C:euchromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140898">
        <property type="term" value="P:CENP-A eviction from euchromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070481">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, non-stop decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030466">
        <property type="term" value="P:silent mating-type cassette heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00074">
        <property type="entry name" value="HFD_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000021">
        <property type="entry name" value="Histone H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002119">
        <property type="entry name" value="Histone_H2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032454">
        <property type="entry name" value="Histone_H2A_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23430">
        <property type="entry name" value="HISTONE H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16211">
        <property type="entry name" value="Histone_H2A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00620">
        <property type="entry name" value="HISTONEH2A"/>
    </dbReference>
    <dbReference type="SMART" id="SM00414">
        <property type="entry name" value="H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0007">Acetylation</keyword>
    <keyword id="KW-0010">Activator</keyword>
    <keyword id="KW-0156">Chromatin regulator</keyword>
    <keyword id="KW-0158">Chromosome</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0544">Nucleosome core</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_0000055333" description="Histone H2A.Z">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-acetyllysine" evidence="1">
        <location>
            <position position="5"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-acetyllysine" evidence="1">
        <location>
            <position position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="136" mass="14605" checksum="90174B18B3F02F2A" modified="2005-04-26" version="1">MPGGKGKSIGGKAGSKDSAGKAQKSHSAKAGLQFPCGRVKRFLKNNTQNKMRVGAKAAVYVTAVLEYLTAEVLELAGNAAKDLKVKRITPRHLQLAIRGDEELDTLIRATIAFGGVLPRINRALLLKVEQKKKKDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AV35</accession>
    <accession>C8VDX4</accession>
    <name>Q5AV35_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ANIA_07845</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001304">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
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        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
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        <property type="entry name" value="RT_dom"/>
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    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
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    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="RVT_1"/>
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        <property type="entry name" value="RT_POL"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="7">
        <location>
            <begin position="96"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBF80228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="533" mass="62201" checksum="7C22FDD1FA35E0C6" modified="2005-04-26" version="1">MGGFIQRKRCRGQDIEIFAVSLADIQKAQAPKRHIDPRTKLPRQYWKYLRLFEQDKAEELPPHRGDGIDHKIELVQEESGKDPEVPCRPLNSLVTDAKRLYPRDHSPAAAPVLFVRKPGGGLRFCVDYRALNAITKKDRYPLPLIHETLNQIGQARWFTKLDVSAAFHKIRIAKGQEWMTAFRTRYGLFEWLVTPFGLANAPSTFQKYINWTLREYLDEFCSAYIDDVLVYTNGDLRQHRKHVRMVLKKLEEAGLYLDIKKCEFECKETKYLGFIIQAGKGIKMDPEKVKAIKEWETPTTIKGVRGFLGFANFYRRFIPNFSGIQPSTLPTVRNSPAECNYEIYDKELLAIVRCLEAWDAELRSCGEFQVITDHKNLEYFFSPRKLTERHVRWSLFLSRFNFKLVYRKGSANQRADALSRRDQDMPDDEDDRVKSRTMQLFTEKHLGKTVVATLRPAEEQPWEPYEKSDMWKEALKQDERYSEAVLCLKDGARRFPPHLQLKVGISECQLDAQDHILFRGRRTSWPRANIFAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AVI8</accession>
    <accession>C8VC52</accession>
    <name>Q5AVI8_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ANIA_07692</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF79914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_680961.1">
        <property type="nucleotide sequence ID" value="XM_675869.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AVI8"/>
    <dbReference type="GeneID" id="2869385"/>
    <dbReference type="KEGG" id="ani:ANIA_07692"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN7692"/>
    <dbReference type="HOGENOM" id="CLU_1454392_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AVI8"/>
    <dbReference type="OrthoDB" id="10252009at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF79914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="186" mass="20430" checksum="E26360234A81116E" modified="2005-04-26" version="1">MSATQTRTPWPALDRIDAVPGLYISEQIFSSYPQLIARCAAPGTTAAAGVQPGLKPQYQIQRKQIELEDDPTEDLLGCLNSLGALRTGHFVLGGCDSRLYNAKPSSSVQNRPQNRPAFTATDLAEHRISVAAAGVGVLRIMIKRKAGYEQWVDVVDKIYDRADVMELVRAKEDYLRNLAEMLEGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="148" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AW66</accession>
    <accession>C8VBE0</accession>
    <name>Q5AW66_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">P-type Ca(2+) transporter</fullName>
            <ecNumber evidence="2">7.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">ANIA_07464</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="17">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.10" evidence="2"/>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF79432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_680733.1">
        <property type="nucleotide sequence ID" value="XM_675641.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AW66"/>
    <dbReference type="FunCoup" id="Q5AW66">
        <property type="interactions" value="408"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5AW66"/>
    <dbReference type="GeneID" id="2869699"/>
    <dbReference type="KEGG" id="ani:ANIA_07464"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN7464"/>
    <dbReference type="eggNOG" id="KOG0202">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002360_3_3_1"/>
    <dbReference type="InParanoid" id="Q5AW66"/>
    <dbReference type="OMA" id="KMHACET"/>
    <dbReference type="OrthoDB" id="3352408at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140613">
        <property type="term" value="F:P-type manganese transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070588">
        <property type="term" value="P:calcium ion transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:intracellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006828">
        <property type="term" value="P:manganese ion transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000031">
        <property type="entry name" value="Calcium-transporting ATPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000040">
        <property type="entry name" value="Calcium-transporting ATPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000028">
        <property type="entry name" value="Calcium-transporting P-type ATPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08282">
        <property type="entry name" value="Hydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="350"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="375"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="910"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="951"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="990"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1022"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="15">
        <location>
            <begin position="41"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="640"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="647"/>
            <end position="656"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CBF79432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="1062" mass="114007" checksum="BBB1DD97BCD96205" modified="2005-04-26" version="1">MSRSATPALPFHNGQATGSISPLAAPAGGRSNAAPSVSTSTYSQLSPQETADRLQTSLTHGLTPAEAEIRYIRDGPNELPHEEPEPLWLRFLKQFKETLILLLLASAAVSFFMGNLDDAVSITLAVTIVVTVGFVQEYRSEKSLEALNRLVPHHAHLIRDVPSNSPPIVHPTTAIPDDEFELRELRSKSPSSGSVSAAVKASTTVPAAELVPGDLVLFTVGDRIPADIRITAATDLTLDESNLTGENEPVVKYPDAICNQKNIPTSKIVTPPRSPFYDAPASGTVGADLRLNEQHNIAFMGTLVRSGYGQGIVIGTGAKTEFGSISASLQEIESPRTPLQLSMDRLGQELSYISFGVIALIVVVGLIQGRKLLDMFTIGVSLAVAAIPEGLPIIVTVTLALGVLRMASRGAIMRRLPSVETLGSVNVVCSDKTGTLTLNHMTVTKMWHFDCAEPFEVHHDIASLTPGPAARTVLRIGNIANNARLSRVHANSPASASSAAVLSSTDDDASGSMKSRWVGQPTDVAILDLLDAFGEDDVRDRISARVAETPFSSERKWMGVVIGSGVPGDSTAPIGGPSMAYIKGALEQVLARCDTYLTKDGQEVILDERRRQVVRQAAEQMASEGLRVLSFASGAVRESRGRALGSRSGTPSSKVSSGDEDDRYSGLVFAGLVGMNDPPRKDVHKAIRRLMAGGVRVIMITGDAETTAVAIAKKLGMPIVETPGVRNVLCGQEIDRMGTSELSQALSSVSIFARTSPDHKMKIVRALQSRGDVVAMTGDGVNDAPALKKADIGIAMGKLGTDVAKEAADMILTDDDFSTILRAIEQGKGIFYNIQNFITFQLSTSVAALSLVLLSTMFGFKNPLNAMQILWINILMDGPPAQSLGVEPVDPSIMGRPPRPKSARVLTKPLIQRVLTSAFMIMMGTLAIYIYEMGDDDDVLTGKRSRVVTAHDTTMTFTCFVLFDMFNALTCRSEGKSVLRGEISLFGNKMFNYAVLGSLAGQACVIYLPFLQRVFQTEPLNAAHLFKLVCIASTVFWVDEGRKYYQSLQRRRAVGVGYSVNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="122" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AXD3</accession>
    <accession>C8VB56</accession>
    <name>Q5AXD3_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Membrane-spanning ATPase, putative (AFU_orthologue AFUA_4G03990)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ANIA_07047</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF79190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_664651.1">
        <property type="nucleotide sequence ID" value="XM_659559.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AXD3"/>
    <dbReference type="FunCoup" id="Q5AXD3">
        <property type="interactions" value="594"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5AXD3"/>
    <dbReference type="GeneID" id="2870189"/>
    <dbReference type="KEGG" id="ani:ANIA_07047"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN7047"/>
    <dbReference type="eggNOG" id="KOG0737">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000688_21_14_1"/>
    <dbReference type="InParanoid" id="Q5AXD3"/>
    <dbReference type="OMA" id="CRNAAMR"/>
    <dbReference type="OrthoDB" id="10254455at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140567">
        <property type="term" value="F:membrane protein dislocase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140570">
        <property type="term" value="P:extraction of mislocalized protein from mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034214">
        <property type="term" value="P:protein hexamerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045047">
        <property type="term" value="P:protein targeting to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006626">
        <property type="term" value="P:protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000538">
        <property type="entry name" value="ATPase family AAA domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051701">
        <property type="entry name" value="Mito_OM_Translocase_MSP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45644">
        <property type="entry name" value="AAA ATPASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G12920)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45644:SF3">
        <property type="entry name" value="FI08533P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="8">
        <location>
            <begin position="139"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="373"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="397"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBF79190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="410" mass="44989" checksum="37994B5F288E84B6" modified="2005-04-26" version="1">MASARSPRWQQIQDLIMIAGTSATAYFLVRHLLSRLDFDPDRQKKEEQQRKSAAILRKLDGNLDENSSGESGGKTRKGDLVLNQYEQAIAMDVVAPEDIPVSFKDIGGLEDIIEELKESVIYPLTMPHLFSSTSSLLTAPSGVLLYGPPGCGKTMLAKALAHESGASFINLHISTLTEKWYGDSNKLVNAVFSLARKLQPSIVFIDEIDAVLGTRRSGEHEASGMVKAEFMTHWDGLTSANSLGEPQRVVVLGATNRMQDIDEAILRRMPKKFPVELPPAAQRLGILSLVLKDTKIDRQNFDLHYLVKAMAGMSGSDIKEACRDAAMVPVREFIRQKTAQGLKITSVDPSEVRGLRTEDFFASAGGAQRFIPVATQNIPPETSSEKEWSTEDEAASENGTQQSRTTQAEA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-02-06" modified="2025-06-18" version="110" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AYC8</accession>
    <accession>C8V1N9</accession>
    <name>BST1_EMENI</name>
    <protein>
        <recommendedName>
            <fullName>GPI inositol-deacylase</fullName>
            <ecNumber>3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">bst1</name>
        <name type="ORF">AN6702</name>
    </gene>
    <organism>
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in inositol deacylation of GPI-anchored proteins which plays important roles in the quality control and ER-associated degradation of GPI-anchored proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the GPI inositol-deacylase family.</text>
    </comment>
    <comment type="sequence caution" evidence="4">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="CBF71281" version="1"/>
        </conflict>
        <text>Extended N-terminus.</text>
    </comment>
    <comment type="sequence caution" evidence="4">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="EAA58520" version="1"/>
        </conflict>
        <text>Extended N-terminus.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-"/>
    <dbReference type="EMBL" id="AACD01000112">
        <property type="protein sequence ID" value="EAA58520.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF71281.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_664306.1">
        <property type="nucleotide sequence ID" value="XM_659214.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AYC8"/>
    <dbReference type="SMR" id="Q5AYC8"/>
    <dbReference type="FunCoup" id="Q5AYC8">
        <property type="interactions" value="49"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5AYC8"/>
    <dbReference type="ESTHER" id="emeni-BST1">
        <property type="family name" value="PGAP1"/>
    </dbReference>
    <dbReference type="GlyCosmos" id="Q5AYC8">
        <property type="glycosylation" value="2 sites, No reported glycans"/>
    </dbReference>
    <dbReference type="KEGG" id="ani:ANIA_06702"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN6702"/>
    <dbReference type="eggNOG" id="KOG3724">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006103_1_0_1"/>
    <dbReference type="InParanoid" id="Q5AYC8"/>
    <dbReference type="OrthoDB" id="348976at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050185">
        <property type="term" value="F:phosphatidylinositol deacylase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000056">
        <property type="entry name" value="GPI inositol-deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012908">
        <property type="entry name" value="PGAP1-ab_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039529">
        <property type="entry name" value="PGAP1/BST1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056824">
        <property type="entry name" value="PGAP1_TMD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15495:SF7">
        <property type="entry name" value="GPI INOSITOL-DEACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15495">
        <property type="entry name" value="NEGATIVE REGULATOR OF VESICLE FORMATION-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07819">
        <property type="entry name" value="PGAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25141">
        <property type="entry name" value="PGAP1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25140">
        <property type="entry name" value="PGAP1_TMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00120">
        <property type="entry name" value="LIPASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0653">Protein transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000277638" description="GPI inositol-deacylase">
        <location>
            <begin position="1"/>
            <end position="1140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="782"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="882"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="905"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="952"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1002"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1039"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1070"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1094"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="304"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="862"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="1140" mass="127346" checksum="D9C6E0ABA242EED6" modified="2007-02-06" version="2">MHRRSSGSSPDADDAEDSLASRSSEPSHGCELPEKPLPEIARTGTSIDLRRDTNGKSTPRSRNSSTWRTLSSATTTWASHDPPRYPAVMITPQRLAIEASPDSPHRSRLARLRSPWSCSILTALTTILACVFLFSIVRSFSALQTGSDGCGVPVMSPTFLRMVGFDTEHTRFASKYNLFLYREEGVDPYNHENLGLNGAPVLFLPGNAGSYRQVRSLAAEASRHYAQVVQHDQERLRAGTRSLDFFMIDFNEDMAAFHGQTLLDQAEYVNEAVAYILSLYHDPRRTRRDADLPDPSSVILIGHSMGGIVARTALTMANYQENSVNTIITMSAPHAKAPVSFDSDIVHTYKQINDYWREAYSQTWANNNPLWHVTLISIAGGSRDTVVPSDYASISSLVPETHGFTVFTSTMPDVWIGVDHLSITWCDQFRKAIIKSLFDVVDVRRASQTKPRAERMRIFKKWYLTGLESVSERMLTRNEPSTLVTLEDHTNTILAQGQRLVLRELGHRTGPNVHLLPVPPQGVSGKKFTLLTDQRLDRTGEQGSLEVLFCSVFPLHNGKASSVFALNMDSSDSSGSTRLACKNAAVDEIHLPASTRTSRNAYDRARPFSYLQYDLEDLAEHQFVAVVDKARVPMKGWAIAEFSDSSDALIKARIGLGGLLSAGLKVRLPANRPMLTEVRIPALYSSLLDYKLRVVRHHQAGDPRELFAPLLRQSIADPHESKFFVNVDKVNVNLHGLAPYMPPPLRQTSQNGVSFQLWTDPTCDSTVDITLTVDIVSSLGELVMRYRTVFAAFPLLVVSLTLRKQFQVYDETGFFITFAEGLDSALRSSMPALLLAMSLLASSLATSTKLPTGDDPFHWATNSTETPIDFTKNDLLLGSQDAFFWFLVPLFGLICVGVCVLLNYVALIVLQILSVVYGLWNSKSGYIRRDEKGYLPVFPAPSPRRRMIKMGVLLVLVSTAIPYQFAYLVACIVQLATCVRAQWHAKETRSTAHYNFANYAYSVFILMLWVLPINILVLLVWAHNLVVHWFMPFSSHHNVLSIMPFIILVETMTTGSMIPRVTTRFKHVTSVLLFCIAVYSAVYGVSYAYISHHLVNILAGWLVSIYFFRSGFSLHRFWKIVEGDETPSTPESGSHMKKKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="102" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AYJ8</accession>
    <accession>C8V1B7</accession>
    <name>Q5AYJ8_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosomal protein S28e (AFU_orthologue AFUA_7G04490)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ANIA_06632</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS28 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF71137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_664236.1">
        <property type="nucleotide sequence ID" value="XM_659144.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AYJ8"/>
    <dbReference type="FunCoup" id="Q5AYJ8">
        <property type="interactions" value="881"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5AYJ8"/>
    <dbReference type="GeneID" id="2870378"/>
    <dbReference type="KEGG" id="ani:ANIA_06632"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN6632"/>
    <dbReference type="eggNOG" id="KOG3502">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_178987_1_0_1"/>
    <dbReference type="InParanoid" id="Q5AYJ8"/>
    <dbReference type="OMA" id="NTGMHGE"/>
    <dbReference type="OrthoDB" id="10258930at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04457">
        <property type="entry name" value="S1_S28E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000025">
        <property type="entry name" value="40S ribosomal protein S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00292">
        <property type="entry name" value="Ribosomal_eS28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000289">
        <property type="entry name" value="Ribosomal_eS28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028626">
        <property type="entry name" value="Ribosomal_eS28_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10769">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10769:SF3">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN ES28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01200">
        <property type="entry name" value="Ribosomal_S28e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00961">
        <property type="entry name" value="RIBOSOMAL_S28E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBF71137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="68" mass="7711" checksum="1792A695C6546ABF" modified="2005-04-26" version="1">MDASKTPTKLVKVTRVLGRTGSRGGVTQVRVEFMDDQTRSIIRNVKGPVRVDDILCLLESEREARRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="115" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AYM4</accession>
    <accession>C8V143</accession>
    <name>Q5AYM4_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">Mannosyl-oligosaccharide glucosidase</fullName>
            <ecNumber evidence="11 12">3.2.1.106</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Glucosidase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">ANIA_06606</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="18">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>N(4)-(alpha-D-Glc-(1-&gt;2)-alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] + H2O = N(4)-(alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] + beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:55988"/>
            <dbReference type="Rhea" id="RHEA-COMP:12806"/>
            <dbReference type="Rhea" id="RHEA-COMP:14355"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:59082"/>
            <dbReference type="ChEBI" id="CHEBI:132537"/>
            <dbReference type="EC" id="3.2.1.106"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="13">Glycan metabolism; N-glycan degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Endoplasmic reticulum membrane</location>
            <topology evidence="1 12">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the glycosyl hydrolase 63 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.106" evidence="11 12"/>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF71085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_664210.1">
        <property type="nucleotide sequence ID" value="XM_659118.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AYM4"/>
    <dbReference type="FunCoup" id="Q5AYM4">
        <property type="interactions" value="585"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5AYM4"/>
    <dbReference type="CAZy" id="GH63">
        <property type="family name" value="Glycoside Hydrolase Family 63"/>
    </dbReference>
    <dbReference type="GeneID" id="2870536"/>
    <dbReference type="KEGG" id="ani:ANIA_06606"/>
    <dbReference type="eggNOG" id="KOG2161">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007380_1_0_1"/>
    <dbReference type="InParanoid" id="Q5AYM4"/>
    <dbReference type="OMA" id="IHLDLRC"/>
    <dbReference type="OrthoDB" id="410058at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098553">
        <property type="term" value="C:lumenal side of endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004573">
        <property type="term" value="F:Glc3Man9GlcNAc2 oligosaccharide glucosidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070880">
        <property type="term" value="P:fungal-type cell wall beta-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006491">
        <property type="term" value="P:N-glycan processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009311">
        <property type="term" value="P:oligosaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.110:FF:000003">
        <property type="entry name" value="Probable mannosyl-oligosaccharide glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.110">
        <property type="entry name" value="Glycosyl hydrolase family 63, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031335">
        <property type="entry name" value="Glyco_hydro_63_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031631">
        <property type="entry name" value="Glyco_hydro_63N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038518">
        <property type="entry name" value="Glyco_hydro_63N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004888">
        <property type="entry name" value="Glycoside_hydrolase_63"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10412">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10412:SF11">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03200">
        <property type="entry name" value="Glyco_hydro_63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16923">
        <property type="entry name" value="Glyco_hydro_63N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010175685" description="Mannosyl-oligosaccharide glucosidase" evidence="14">
        <location>
            <begin position="21"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 63 N-terminal" evidence="16">
        <location>
            <begin position="41"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 63 C-terminal" evidence="15">
        <location>
            <begin position="475"/>
            <end position="735"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU368089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU369107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF03200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF16923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CBF71085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="749" mass="83866" checksum="3B86E30A31AA16CB" modified="2005-04-26" version="1">MHLSISSLLSAPLFCAAALAVQVSDGVSTVAHEAARASNESLLWGPYKPNLYFGVRPRIPNSVFAGLMWAKVDNYATAQENFRHTCEQNEGMAGYGWDEYDVRKGGRETIHDAGNSLDLTIDFVKVPGGQHGGSWAARVKGVPRDDALPDQPTTVVFYAGLEGLGSLGVSTESDDPRGFEGDVKLDGFTAELGRFSIDVTAGPKTNEHPAYNHPSYDDKPLDRTIVSSFPVPPEHTWQTKVLLFTQMKKAVDEAIQKYGAENPPPPAQVFTVNNSPGDGNVQLVQKVFSGAFEFDILFSSGSAPEPLTSEILTAEIKSASLSFSERFKKILSPQSPFDSADYLEFSKSMLSNLIGGIGFFHGSDIVDRSAAPEYDEENEGFWEETEEARSRAQPVLEGPKDLFTAVPSRPFFPRGFLWDEGFHLIPILDWDPDLALEIVKSWFSLMDEDGWIAREQILGNEARSKVPPEFTVQSTQYGDIKSYDREAFSTKEAYRWRGRSVQHILTSGLDDYPRAQPPHPGELHVDLISWMGMMTRALRRIAETLGETEDIEEFKAYETAIERNIDDLHWDADAKTYCDATIDDYEDSVHVCHKGYVSIAPFLTGIVGPDSPRLEAILDLIEDPEELWSDYGIRSLSKKDEFYGTAENYWRSPVWININYLVLKNLYNIALTPGPQQNRARKMYSGLRKNLVENVYREWKNTGFAWEQYNPETGKGQRTQHFTGWTSLVVKMMAMPDLPASEKTGHDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AYM6</accession>
    <accession>C8V140</accession>
    <name>Q5AYM6_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongator complex protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ANIA_06604</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ELP5 family.</text>
    </comment>
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        <property type="protein sequence ID" value="CBF71079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_659116.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AYM6"/>
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        <property type="interactions" value="955"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5AYM6"/>
    <dbReference type="GeneID" id="2870523"/>
    <dbReference type="KEGG" id="ani:ANIA_06604"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN6604"/>
    <dbReference type="eggNOG" id="ENOG502QQIZ">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_050414_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AYM6"/>
    <dbReference type="OMA" id="WEPESTF"/>
    <dbReference type="OrthoDB" id="166907at2759"/>
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        <property type="component" value="Chromosome I"/>
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        <property type="term" value="C:cytosol"/>
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        <property type="term" value="C:elongator holoenzyme complex"/>
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        <property type="project" value="GO_Central"/>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19496">
        <property type="entry name" value="Elp5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019519">
        <property type="entry name" value="Elp5"/>
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    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15641">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15641:SF1">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10483">
        <property type="entry name" value="Elong_Iki1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="314"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="337"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009567"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBF71079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="350" mass="39124" checksum="B258C0FFBEAD13E4" modified="2005-04-26" version="1">MAPSKLSHRQTHNLLLVSKLLSLRDTASPLTLLLDSLEQPATPLINEYIRRARLSKVHVTLIAFETLKPYDGVDAFVSTRRKTPAGIVREVAAAYKPDSSNSPNRRRLVLIDSINPLIHSTRTDRSFNLSNFLSSFIVPSEPTATKPDTSLVVTFHQDVPSRPAQSPYSPSPLSLLSYLATTVIKLHSFSHILARKAARDRSLAPPVFGLEEEQDGVLLGRLDNPVGNGSTEAGGVVLEMEYRRKSGRGVLEWYLLPPASNYPATQVKEIVMLLDDHPLYRPPEDLDARSENEEPESTFELRLTERQRREREGVVLPYFDAQQGNGPGEGGRILYDMGEEDDFDEEEDEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AYU1</accession>
    <accession>C8V0M1</accession>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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        <name evidence="1" type="ORF">ANIA_06539</name>
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    <organism evidence="1 2">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
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        <lineage>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CBF70943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_659051.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AYU1"/>
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    <dbReference type="KEGG" id="ani:ANIA_06539"/>
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    <dbReference type="InParanoid" id="Q5AYU1"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF70943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="38" mass="4677" checksum="0E7C303816A01677" modified="2005-04-26" version="1">MLLQDDLCMVIEGQPDRAFRNERNMYNIQTNIFVWVFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="125" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AZ92</accession>
    <accession>C8V0P8</accession>
    <name>Q5AZ92_EMENI</name>
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        <submittedName>
            <fullName evidence="10">Beta-galactosidase (Eurofung)</fullName>
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    </protein>
    <gene>
        <name evidence="10" type="ORF">ANIA_06388</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Eurotiomycetes</taxon>
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            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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    <reference evidence="11" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF69565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_663992.1">
        <property type="nucleotide sequence ID" value="XM_658900.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AZ92"/>
    <dbReference type="STRING" id="227321.Q5AZ92"/>
    <dbReference type="CAZy" id="GH2">
        <property type="family name" value="Glycoside Hydrolase Family 2"/>
    </dbReference>
    <dbReference type="GeneID" id="2871287"/>
    <dbReference type="KEGG" id="ani:ANIA_06388"/>
    <dbReference type="eggNOG" id="KOG2024">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006501_0_1_1"/>
    <dbReference type="InParanoid" id="Q5AZ92"/>
    <dbReference type="OMA" id="FPKDRYW"/>
    <dbReference type="OrthoDB" id="408532at2759"/>
    <dbReference type="UniPathway" id="UPA00280"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032311">
        <property type="entry name" value="DUF4982"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048229">
        <property type="entry name" value="GalB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051913">
        <property type="entry name" value="GH2_Domain-Containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040605">
        <property type="entry name" value="Glyco_hydro2_dom5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006101">
        <property type="entry name" value="Glyco_hydro_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023232">
        <property type="entry name" value="Glyco_hydro_2_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006103">
        <property type="entry name" value="Glyco_hydro_2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006104">
        <property type="entry name" value="Glyco_hydro_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Ig-like_GH2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041463">
        <property type="entry name" value="GalB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42732">
        <property type="entry name" value="BETA-GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42732:SF1">
        <property type="entry name" value="BETA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16355">
        <property type="entry name" value="DUF4982"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18565">
        <property type="entry name" value="Glyco_hydro2_C5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02836">
        <property type="entry name" value="Glyco_hydro_2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02837">
        <property type="entry name" value="Glyco_hydro_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00132">
        <property type="entry name" value="GLHYDRLASE2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="beta-Galactosidase/glucuronidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00608">
        <property type="entry name" value="GLYCOSYL_HYDROL_F2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030175751" evidence="4">
        <location>
            <begin position="23"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolases family 2 sugar binding" evidence="7">
        <location>
            <begin position="117"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich" evidence="5">
        <location>
            <begin position="254"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 2 catalytic" evidence="6">
        <location>
            <begin position="368"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4982" evidence="8">
        <location>
            <begin position="708"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 2" evidence="9">
        <location>
            <begin position="780"/>
            <end position="882"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF18565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBF69565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="891" mass="99689" checksum="F5893410B9D5BB3A" modified="2005-04-26" version="1">MKLQSCAYLGWGLALAASSAVALSVRNTNKAPSQSVRERASLNHQWKFWHSEQIPDNIVYDLRPDANDSSFQVLKSWVLPVGNDYIKNANAQHERPSTEPDGDIPYVHNDFDDSSWDVVRLPHDWAITRPFYTDDDPEIPSAMGRLPVQGVGWYRRKLNFTQEDSDKVVLLEIDGAMSYPMVWLNGHLVGGWPYGYNSFQLDLTPYLQQGEENQLAIRVENPSGSSSRWYPGGGIYRNVWLTKVNPTHVAHYGTKMTTRDVSSRRATIDFQVQIENKGQKRQRVEVATEIFDLDSANGHVRGRKVEQFPRHKVIVDKDNPRLWGPPPDQTPNLYIAVTSLYDASGHLLDTYSTEFGVRSVEYNPNTGLSVNGAPVRIQGVNQHHDLGALGAAFNRRAAQRQLELLCDLGVNAIRTAHNPPAPELLEMTDRMGFLVLDEIFDSWAQQKTDLDFHLIFNDWREPDLRSFLRRDRNHPSVIIWSIGNEVAEQSADDTAAAIATYLRDIVREEDNTRPVTASMNSAWPNSSFAGVVDLISLNYQGEGLRYGPAYSHLEGNRRDPQYSEFHVTHPDKLILGSEVAWSLSTRGTFLFPVTNYTSAPVNDTSGGNSTTLEISAYELYSSDPGSSPDRVFATQDEHPFVDGGFVWAGWDYLGEPYPYYDGARSAYSGIIDLAGFKKERFYLYQARWQPDVRMAHIVPHWSWPERVGQVTPVHVFTSGDEAELFVNGVSQGRLKRDPLTYRFRWDEVVYEPGEVQVVAYKNGSKWATDTVKTAGEPTQLRLTPDRAQIAADGEDLSFVTLEVLDGKGNVVPEAKNLIHFEVSGPGEIVATDNGFPADYTAFPSHERTAFHGLALCIVKGELGTHGDIVLKASSNGVGEAEVVIKASRGMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="122" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AZM6</accession>
    <accession>C8V1J0</accession>
    <name>Q5AZM6_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Mitochondrial thiamine pyrophosphate carrier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">ANIA_06254</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF69848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_663858.1">
        <property type="nucleotide sequence ID" value="XM_658766.1"/>
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    <dbReference type="AlphaFoldDB" id="Q5AZM6"/>
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        <property type="interactions" value="894"/>
    </dbReference>
    <dbReference type="GeneID" id="2871156"/>
    <dbReference type="KEGG" id="ani:ANIA_06254"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN6254"/>
    <dbReference type="eggNOG" id="KOG0759">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_14_1_1"/>
    <dbReference type="InParanoid" id="Q5AZM6"/>
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        <property type="component" value="Chromosome I"/>
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    <dbReference type="GO" id="GO:0005743">
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        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0015140">
        <property type="term" value="F:malate transmembrane transporter activity"/>
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    <dbReference type="GO" id="GO:0015131">
        <property type="term" value="F:oxaloacetate transmembrane transporter activity"/>
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        <property type="term" value="F:succinate transmembrane transporter activity"/>
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        <property type="term" value="F:sulfate transmembrane transporter activity"/>
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        <property type="term" value="F:thiosulfate transmembrane transporter activity"/>
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    </dbReference>
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        <property type="term" value="P:thiosulfate transport"/>
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    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000107">
        <property type="entry name" value="Mitochondrial dicarboxylate carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050391">
        <property type="entry name" value="Mito_Metabolite_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45618">
        <property type="entry name" value="MITOCHONDRIAL DICARBOXYLATE CARRIER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00784">
        <property type="entry name" value="MTUNCOUPLING"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="21"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="114"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="214"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CBF69848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="308" mass="34013" checksum="61400BB4181CD91E" modified="2005-04-26" version="1">MASTAKLEISHPQQQVVKPVKKVHYPFWFGGSASCFAAAVTHPLDLVKVRLQTRGPGAPSTMLGTFGHILRNNGFFGLYNGLSAALLRQLTYSTTRFGIYEELKSRFTSPSQSPSFFTLLGMACTSGILGGIAGNPADVLNVRMQSDAALPPAQRRNYRHAFHGLVQMTRTEGFSSLFRGVWPNSTRAVLMTSSQLVSYDVFKRLCLEKFGMKDNVVTHFSASFAAGFVATTVCSPVDVIKTRVMSASPSETRGHNIVGLLREISRKEGLAWAFRGWVPSFIRLGPHTIATFIFLEEHKKLYRYLKGI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-05-05" modified="2026-01-28" version="104" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B0R3</accession>
    <accession>C8UZZ0</accession>
    <name>NAGS_EMENI</name>
    <protein>
        <recommendedName>
            <fullName>Amino-acid acetyltransferase, mitochondrial</fullName>
            <ecNumber>2.3.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Arginine-requiring protein 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Glutamate N-acetyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>N-acetylglutamate synthase</fullName>
            <shortName>AGS</shortName>
            <shortName>NAGS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">arg2</name>
        <name type="synonym">ornD</name>
        <name type="ORF">AN5867</name>
    </gene>
    <organism>
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">N-acetylglutamate synthase involved in arginine biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>L-glutamate + acetyl-CoA = N-acetyl-L-glutamate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24292"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:44337"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text>Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 1/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the acetyltransferase family.</text>
    </comment>
    <comment type="sequence caution" evidence="5">
        <conflict type="erroneous gene model prediction">
            <sequence resource="EMBL-CDS" id="EAA58376" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EC" id="2.3.1.1"/>
    <dbReference type="EMBL" id="AACD01000100">
        <property type="protein sequence ID" value="EAA58376.1"/>
        <property type="status" value="ALT_SEQ"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF70677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B0R3"/>
    <dbReference type="SMR" id="Q5B0R3"/>
    <dbReference type="FunCoup" id="Q5B0R3">
        <property type="interactions" value="107"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5B0R3"/>
    <dbReference type="EnsemblFungi" id="CBF70677">
        <property type="protein sequence ID" value="CBF70677"/>
        <property type="gene ID" value="ANIA_05867"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AN5867"/>
    <dbReference type="eggNOG" id="KOG2436">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013088_0_0_1"/>
    <dbReference type="InParanoid" id="Q5B0R3"/>
    <dbReference type="OMA" id="NAMVRDC"/>
    <dbReference type="OrthoDB" id="5585968at2759"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00106"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004042">
        <property type="term" value="F:L-glutamate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006592">
        <property type="term" value="P:ornithine biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000049">
        <property type="entry name" value="Amino-acid acetyltransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011190">
        <property type="entry name" value="GlcNAc_Synth_fun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006855">
        <property type="entry name" value="Vertebrate-like_GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23342:SF4">
        <property type="entry name" value="AMINO-ACID ACETYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23342">
        <property type="entry name" value="N-ACETYLGLUTAMATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04768">
        <property type="entry name" value="NAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007892">
        <property type="entry name" value="NAGS_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51731">
        <property type="entry name" value="GNAT_NAGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0012">Acyltransferase</keyword>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0809">Transit peptide</keyword>
    <feature type="transit peptide" description="Mitochondrion" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000372563" description="Amino-acid acetyltransferase, mitochondrial">
        <location>
            <begin position="36"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="527"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="367"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="367"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="389"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <sequence length="706" mass="77600" checksum="CC32AC6744BB5116" modified="2011-11-16" version="2" precursor="true">MSSRVLASRAAQPLKRHPTVVGAGDEAYPTPRRCFSSLHDRTVNQSADFSSTSKNYDRLGRRAKEKLLDREFFMSLLNSASTKREAKSYLARLKAQQPAKPQKKLQSTTVQQTIAESLPSGVNLGSFYGASRSVYQSPVFRQDSTPAPAREDIPERLHLALVKIKTPQLLDDSTLDGVARTLSQINRLGLACCVVVDPGSDGDTHTLRKIATEQVGRIATAVDRQPDSKSSHLYSVLSFPAKRPDIPTVSSRKQLLSPLRDGHILIVAPIAYTEDTPKALMVPANDAVLALTKELAGLATMPDPDEDPMITAQKINDLQKEVSLDRVILLDPLGGVPAFRGPQTSHAFINMDQEFEHIERELLQVRNPANNSQGESVVTNPISDSNAVSESASTEPTSTPAKQALLPMSVGEDTIDGHLDNLRLSQQTLAMLPSASSGIITSPVEVANSARSLESSPSELSVGTRRQRNPLIHNLLTDKPLLSSSLPLSRRARGSLHLPAPPTTFVKRGMPVSLIPDPRVQVWTAQTRPNMNLDDPHVDLPRLVHLIEDSFNRKLDVKDYLNRVNGRLAGLIIAGEYEGGAILTWELPPGVEDDGSESSTARMVPYLDKFAVLKRSQGAGGVADIVFNAMVRTCFPNGVCWRSRKDNPVNKWYFERSLGSWKLADTNWTMFWTTPDLPEKPQKFRDYEAVCRSIQPSWAEDTGVID</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="111" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B0V2</accession>
    <accession>C8V074</accession>
    <name>Q5B0V2_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytochrome b5, putative (AFU_orthologue AFUA_2G07720)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ANIA_05828</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the cytochrome b5 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF70764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_663432.1">
        <property type="nucleotide sequence ID" value="XM_658340.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B0V2"/>
    <dbReference type="STRING" id="227321.Q5B0V2"/>
    <dbReference type="GeneID" id="2871192"/>
    <dbReference type="KEGG" id="ani:ANIA_05828"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN5828"/>
    <dbReference type="eggNOG" id="KOG0537">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_102602_4_4_1"/>
    <dbReference type="InParanoid" id="Q5B0V2"/>
    <dbReference type="OMA" id="FWKYHGD"/>
    <dbReference type="OrthoDB" id="260519at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000007">
        <property type="entry name" value="Sulfite oxidase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050668">
        <property type="entry name" value="Cytochrome_b5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19359">
        <property type="entry name" value="CYTOCHROME B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19359:SF14">
        <property type="entry name" value="CYTOCHROME B5 A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0349">Heme</keyword>
    <keyword evidence="3 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="6">
        <location>
            <begin position="2"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBF70764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="84" mass="9373" checksum="E39B10BFE0B5A533" modified="2005-04-26" version="1">MSKTFTPAEVAKHNKPDQGLYIIVDNSVYDVTNFVDEHPGGAKILKRVAGKDASKQFWKYHNDGVLKKYAPKLKIGEVKEGAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B1D8</accession>
    <accession>C8VFV5</accession>
    <name>Q5B1D8_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_05642</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF81493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_663246.1">
        <property type="nucleotide sequence ID" value="XM_658154.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B1D8"/>
    <dbReference type="FunCoup" id="Q5B1D8">
        <property type="interactions" value="14"/>
    </dbReference>
    <dbReference type="GeneID" id="2871934"/>
    <dbReference type="KEGG" id="ani:ANIA_05642"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN5642"/>
    <dbReference type="eggNOG" id="ENOG502S6F0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_997649_0_0_1"/>
    <dbReference type="InParanoid" id="Q5B1D8"/>
    <dbReference type="OMA" id="KNAVCEQ"/>
    <dbReference type="OrthoDB" id="21418at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029196">
        <property type="entry name" value="HAPSTR1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38645">
        <property type="entry name" value="CHROMOSOME 9, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38645:SF1">
        <property type="entry name" value="YALI0F12243P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15251">
        <property type="entry name" value="TAPR1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="177"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF81493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="261" mass="28813" checksum="CB19B9674AEE9B48" modified="2005-04-26" version="1">MDSMRSLNTSLPSSTPRPPSEQLLQQFRTAALSVTNLYKNAVYAESQARQAGYQEAIEDLLHFLDRENLGLTDGEGWRVRQWATERSDGLAHSSDDDDAERTRCTTPAVARKEPSESEAPRHQSKPTSPHREEQAPAQQPPSTPAAQPSEPVILDRPPLFTFAAGPTFPQVHEQDMDMQNSDSSSSSPQSDTPATVSVLARNSRQQSRHVNLTRPSPRNSTRDSPVGIGSKRKNNFPDFFDLSGLGNNRDLFGGGKRGRFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="122" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B1N8</accession>
    <accession>C8VG70</accession>
    <name>Q5B1N8_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ANIA_05542</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF81706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_663146.1">
        <property type="nucleotide sequence ID" value="XM_658054.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B1N8"/>
    <dbReference type="GeneID" id="2871834"/>
    <dbReference type="KEGG" id="ani:ANIA_05542"/>
    <dbReference type="eggNOG" id="KOG0143">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010119_10_3_1"/>
    <dbReference type="InParanoid" id="Q5B1N8"/>
    <dbReference type="OMA" id="WENVQSH"/>
    <dbReference type="OrthoDB" id="406156at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044283">
        <property type="term" value="P:small molecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.330:FF:000028">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.142, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050295">
        <property type="entry name" value="Plant_2OG-oxidoreductases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47991">
        <property type="entry name" value="OXOGLUTARATE/IRON-DEPENDENT DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00682">
        <property type="entry name" value="IPNSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="6">
        <location>
            <begin position="205"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBF81706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="414" mass="47444" checksum="B62B8FFDCFF95094" modified="2005-04-26" version="1">MTPAAPFNPPSPNLPGKPFVPEWNPPPVTKQTESFATLKSIDLSLLDSEDPVVVNRLIQQVKIAIRDDGFLFLENYGVSLEQLHRQFALAQYLYNNMSEEDKERLLFDPETGRWSGYKHPYGFKRHRGPPDGIEQFNFYTREWNDPSRIPTCLHPFMDEITAFCNYLTQSVNRRLLTLFSRVLELPDDYLWENVQSHGSPTGEGYFRHALFRPVQKETQEASKGLRMHGHTDFGLTTLLFSVPVSCLQIWGRDEKWYYVPYKPGALVINIGDTLEIVSGGHFKATRHRVYKPPADQLNEERLSLVLFNSSVGELRMQPAYESPLIQREGCIEEQGVYKEFKRLTEAGQLVPSNREWREIQIATATDPTDTDHNRIGVHQLCVISVASSSQYLILIPGHGSRQIMVQSWTQRHAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="108" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B284</accession>
    <accession>C8VGT0</accession>
    <name>Q5B284_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chitobiosyldiphosphodolichol beta-mannosyltransferase</fullName>
            <ecNumber evidence="3">2.4.1.142</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">ANIA_05346</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Participates in the formation of the lipid-linked precursor oligosaccharide for N-glycosylation. Involved in assembling the dolichol-pyrophosphate-GlcNAc(2)-Man(5) intermediate on the cytoplasmic surface of the ER.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.4.1.142" evidence="3"/>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF82063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_662950.1">
        <property type="nucleotide sequence ID" value="XM_657858.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B284"/>
    <dbReference type="FunCoup" id="Q5B284">
        <property type="interactions" value="891"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5B284"/>
    <dbReference type="CAZy" id="GT33">
        <property type="family name" value="Glycosyltransferase Family 33"/>
    </dbReference>
    <dbReference type="GeneID" id="2871639"/>
    <dbReference type="KEGG" id="ani:ANIA_05346"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN5346"/>
    <dbReference type="eggNOG" id="KOG2941">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012079_1_0_1"/>
    <dbReference type="InParanoid" id="Q5B284"/>
    <dbReference type="OMA" id="CKLIIDW"/>
    <dbReference type="OrthoDB" id="614844at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004578">
        <property type="term" value="F:chitobiosyldiphosphodolichol beta-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000030">
        <property type="term" value="F:mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd03816">
        <property type="entry name" value="GT33_ALG1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000162">
        <property type="entry name" value="Beta-1,4-mannosyltransferase (Alg1), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026051">
        <property type="entry name" value="ALG1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13036">
        <property type="entry name" value="BETA1,4 MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13036:SF0">
        <property type="entry name" value="CHITOBIOSYLDIPHOSPHODOLICHOL BETA-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13692">
        <property type="entry name" value="Glyco_trans_1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CBF82063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="461" mass="50900" checksum="3058257DE5BB346E" modified="2005-04-26" version="1">MIESVIEVAFFVSTIVTLFILMLPSQYEPKRRVAGSSDDLSEPKTTVQVLVLGDIGRSPRMQYHALSIARGGGHVDIIGYSESEIHPDVSSHPNISVVPIPPHPSVLQTSNKVLFLFVAPLKVLFQVIALWWILAYHTKPAKWLLIQNPPSIPTLAIASLVCFFRQTRLVIDWHNFGYTILALKLGDTHPLVKVSKWYENVFCRSAVAHFCVTNAMASVLKKEFDLQAPILPLHDRPASHFRPILDEQERKSFLLSLPEAAPMRRSIEEGNTKVIVSSTSWTPDEDFSLLIDALCRYSEVSSTTKPHLPAVLAIITGKGPQRDIYVERISRLQKEGKLSKVTICTAWLSTGDYARLLASASLGVSLHTSSSGVDLPMKVVDMFGSGLPVVGWSKFRAWPELVTDGVNGKGFGSPSELAEQLVELLGNPENLNMLRAGAQDASAFRWDDEWAPVAGKLFGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B2C5</accession>
    <accession>C8VGX4</accession>
    <name>Q5B2C5_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF1680 domain protein (AFU_orthologue AFUA_1G08910)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ANIA_05305</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF82133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_662909.1">
        <property type="nucleotide sequence ID" value="XM_657817.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B2C5"/>
    <dbReference type="GeneID" id="2871598"/>
    <dbReference type="KEGG" id="ani:ANIA_05305"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN5305"/>
    <dbReference type="eggNOG" id="ENOG502SJQM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013148_1_0_1"/>
    <dbReference type="InParanoid" id="Q5B2C5"/>
    <dbReference type="OMA" id="ANRGENE"/>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049174">
        <property type="entry name" value="Beta-AFase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049049">
        <property type="entry name" value="Beta-AFase-like_GH127_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012878">
        <property type="entry name" value="Beta-AFase-like_GH127_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049046">
        <property type="entry name" value="Beta-AFase-like_GH127_middle"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43465">
        <property type="entry name" value="DUF1680 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G08910)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43465:SF2">
        <property type="entry name" value="DUF1680 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G08910)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07944">
        <property type="entry name" value="Beta-AFase-like_GH127_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20737">
        <property type="entry name" value="Glyco_hydro127C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20736">
        <property type="entry name" value="Glyco_hydro127M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Non-reducing end beta-L-arabinofuranosidase-like GH127 catalytic" evidence="1">
        <location>
            <begin position="10"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="Non-reducing end beta-L-arabinofuranosidase-like GH127 middle" evidence="2">
        <location>
            <begin position="430"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="Non-reducing end beta-L-arabinofuranosidase-like GH127 C-terminal" evidence="3">
        <location>
            <begin position="522"/>
            <end position="623"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBF82133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="629" mass="71256" checksum="AE9BE9BD0C28D151" modified="2005-04-26" version="1">MAFQQVPVRNVNITSAFWSQMRQCSKEKTIPAIIKAQKSLQHWYCLTWKEGHEIQPHPFWDSDIYKIVEAACYFLMKDKDDELMATVEEAADMIRAAQHPDGYINSYYTVLGIDKRWTNLRDMHELYCLGHLTEACVAYETLTNSGRLLEPVLKALRHVDSVFGAEPGKKRGYPGHQEIEIGLLRLYELCGEPVLLKLAKYFISERGRRDTNGETYFDHEARARGGDPYDHFGSEMKAWFQHPRDYSYNQADRPLVETTEVKGHAVRAMYYYIAATDLVRLTGDEEIKAALDRMWMDMTERKLYVTGGIGAMRQWEGFGAKYVLADTDESGICYAETCACFALIIWCQRMLQLDLDAKYADVMEVGLYNGFLGAVGLDGGSFYYQNPLRTYTGHPKERSEWFEVACCPPNVAKLLGSMESLIYSFKDDLVAIHLYIESDFTVPETGVVVSQKTNMPWSGDVEISVKGTTALALRIPTWAEGYSSSVQGEVKNGYLYIPHSQDLEVKLSFTLKARKLYPNPATEKDQICITRGPLVYCIEDVDNEVDIDHVGLVDGPVTDGEPIDIATVNDVIPVKATGRELVKGQNHLYASEPWKYGDKKNLLYVPYFLRANRGGKGGMTVWAKRLEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="119" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B364</accession>
    <accession>C8V8K8</accession>
    <name>Q5B364_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ANIA_05016</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF76273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_662620.1">
        <property type="nucleotide sequence ID" value="XM_657528.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B364"/>
    <dbReference type="ESTHER" id="emeni-q5b364">
        <property type="family name" value="Fungal_carboxylesterase_lipase"/>
    </dbReference>
    <dbReference type="GeneID" id="2872812"/>
    <dbReference type="KEGG" id="ani:ANIA_05016"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN5016"/>
    <dbReference type="eggNOG" id="KOG4389">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006586_10_6_1"/>
    <dbReference type="InParanoid" id="Q5B364"/>
    <dbReference type="OMA" id="ETWAANG"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000292">
        <property type="entry name" value="Carboxylic ester hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050654">
        <property type="entry name" value="AChE-related_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918">
        <property type="entry name" value="ACETYLCHOLINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918:SF4">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010392562" description="Carboxylic ester hydrolase" evidence="3">
        <location>
            <begin position="18"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="5">
        <location>
            <begin position="28"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="249"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBF76273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="549" mass="60525" checksum="A02695F46EA0BD9F" modified="2005-04-26" version="1">MWTFIAGLLTLSLGISATSFPRDNAGAPTARVKNGTYEGVYSPEYDQDFFLGVPFAQPPVNDLRFRLPQSLNATWEGTREAKDYSLLCVGYGLDQTFYNQSEDCLYLNIVRPAGYDQEKLPVGFWIHGGGFSNGGGGDQRYNLSFIVKQSVKIGKPIIGVSINYRLNLWGFLHSNEVVGEGITNLGLRDQRLALYWVQENIATFGGDPGKVTIFGESAGAASVGFHVATTSSSAPQYYSLVIPYSTEPKMERSARKPPSRRSYPRLDAPRPGTGSNVSREVSFLTLNATYDSINGSFAPTIDGDFIRTYGSKQLLDGQFVRVPIITGTNSDEGASMSPTGINTTEDFKATLSSFLPVSFQDAILKAYPDDLSVNVIASLGDQRPVAPYGAQFRRSASFWGDYYFIASRRQTAKTWAAHGIPAYAYRFNAIPAGVPPEVGVGHYKEIGFMFNNLEGVGYRPDIKPFEGKGQNYIDLADLMSSTWASFIHDLDLNNYTGRDTNIPDWPRYDVLEPRDFVFDANVTSYTEDDTYRAEGIALINDHAAGVLHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="113" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B3P9</accession>
    <accession>C8VA92</accession>
    <name>Q5B3P9_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aryl-alcohol dehydrogenase Aad14, putative (AFU_orthologue AFUA_2G11250)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ANIA_04831</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF76678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_662435.1">
        <property type="nucleotide sequence ID" value="XM_657343.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B3P9"/>
    <dbReference type="GeneID" id="2872629"/>
    <dbReference type="KEGG" id="ani:ANIA_04831"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN4831"/>
    <dbReference type="eggNOG" id="KOG1575">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_2_2_1"/>
    <dbReference type="InParanoid" id="Q5B3P9"/>
    <dbReference type="OMA" id="QWTAHID"/>
    <dbReference type="OrthoDB" id="48988at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF7">
        <property type="entry name" value="NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="4">
        <location>
            <begin position="30"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBF76678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="384" mass="42726" checksum="2A5FBC78C770DB19" modified="2005-04-26" version="1">MSFWTFAPKPKTPLGYHRVLSPTAGVKVSPLCLGGMNFGEGWEHFMGKCSKDDAFALMDAFYNMGGNFIDTANNYQEGDSERWIGEWMESRGNRDQIVLATKYTTGFRDQNIDTERIQSNFVGNSVKSLQTSVKHSLRNLRTDYIDLLYVHWWDFTSGVEEVMHGLNALVTAGKVLYLGVSDTPAWVVVKANEYARANGLRPFSVYQGLWNPLRRDMESEIIPMCRDQGMGIAPWGPLAQGKLKTAKARGVKGGGRSDGDMTEDEIRVSDALDEVAKSRNTTLAAVALAYLLHKTPYVFPIVGQRKIEHLKANVQALEIELTKEDMDKIDAAVPFDPGFPMSFIFPGKYDLTLTAADVPLTRKAGHIDAPPQQGIVPPRKMSQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B3R6</accession>
    <accession>C8VAK2</accession>
    <name>Q5B3R6_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">UPF0016 domain protein, putative (AFU_orthologue AFUA_3G07080)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ANIA_04814</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GDT1 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF76725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_662418.1">
        <property type="nucleotide sequence ID" value="XM_657326.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B3R6"/>
    <dbReference type="FunCoup" id="Q5B3R6">
        <property type="interactions" value="674"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5B3R6"/>
    <dbReference type="GeneID" id="2872601"/>
    <dbReference type="KEGG" id="ani:ANIA_04814"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN4814"/>
    <dbReference type="eggNOG" id="KOG2881">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040186_3_0_1"/>
    <dbReference type="InParanoid" id="Q5B3R6"/>
    <dbReference type="OMA" id="YWWVTIG"/>
    <dbReference type="OrthoDB" id="442680at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015085">
        <property type="term" value="F:calcium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070588">
        <property type="term" value="P:calcium ion transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032468">
        <property type="term" value="P:Golgi calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032472">
        <property type="term" value="P:Golgi calcium ion transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071421">
        <property type="term" value="P:manganese ion transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001727">
        <property type="entry name" value="GDT1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049555">
        <property type="entry name" value="GDT1-like_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12608:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 165"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12608">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN HTP-1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01169">
        <property type="entry name" value="GDT1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01214">
        <property type="entry name" value="UPF0016"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010201193" evidence="8">
        <location>
            <begin position="22"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="280"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="312"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="416"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="461"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="494"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="50"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="334"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="96"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="123"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="199"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="343"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="395"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBF76725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="516" mass="55162" checksum="2A3A963C38ADD9E0" modified="2005-04-26" version="1">MKFHTTTRVLLLLPAITTVLSDKVSEYNNGNEISVAERDTSTVNAVVPGLDELAPKPSPRGTQDAPVDGKDGRPHAGPWVETNAERDRKSSGTLNEQAQQIAESAEQLDSNGRPIPYSNDGVMDDRNRAAPKEGTRGTEGGVSGKLKDSTYSGDKSPGSPKEAPPLPHSEEQKLPSTGDNSGKDTKGYSSDSTLGVLERPADMPGKPHDIPLPKSPTTVKDGLVGLNKEGSSTAGNKVPPEEERDAFHSLLFSFTMIVVSEIGDKTFLVAALMAMRHPRLLVFSAAFSALIGMTVLSAVLGHAVPSLIPKTFTKFLAAVLFFVFGAKMLKEGREMSPDEGVGEEMREVEQELEEKEHEQLRMSRRRSSVTPHALEAGRLGRKPRSSANRLPSPPESLSSSSSRGSSPQPGQRWNDLLVGLNNLFSLLLSPAWVQTFVMTFLGEWGDRSQIATIAMAAGQDYWFVTIGAITGHGLCTAAAVIGGSAIAGKVSMRVVTLGGAAAFLVFGCIYLLEALF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B408</accession>
    <accession>C8VAV3</accession>
    <name>Q5B408_EMENI</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
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    <gene>
        <name evidence="3" type="ORF">ANIA_04722</name>
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    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF76924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_662326.1">
        <property type="nucleotide sequence ID" value="XM_657234.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B408"/>
    <dbReference type="GeneID" id="2872523"/>
    <dbReference type="KEGG" id="ani:ANIA_04722"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN4722"/>
    <dbReference type="eggNOG" id="ENOG502SSMZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_818970_0_0_1"/>
    <dbReference type="InParanoid" id="Q5B408"/>
    <dbReference type="OMA" id="PPHHTEP"/>
    <dbReference type="OrthoDB" id="4511137at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="68"/>
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        </location>
    </feature>
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            <begin position="93"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="112"/>
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        </location>
    </feature>
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            <begin position="125"/>
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            <begin position="151"/>
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            <begin position="170"/>
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        </location>
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            <begin position="191"/>
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        </location>
    </feature>
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        <location>
            <begin position="210"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="271"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF76924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="339" mass="35604" checksum="D8A72D4849854C13" modified="2005-04-26" version="1">MTGTGATVEVVTVVTAVTAVMAVMTMMTMMITTGSLPQPLPVRQRRKLLRQRPLHARRKLKTPPPETTPCETETETPSTESPPPETTPCETETPPPSTETPPPETTPCETETPPPSTETPPPETTPCETETETPPSTETPPPETTPCETETPPPSTETPPPETTPCETETPPPSTETPPPETTPCETETETPPPETETPPPETTPCETETPPPSTETPPPETTPCETETETPPPSTETPPPETTPCETETETPPPETETPPEETPAPAPPSTSSWTTSTSVTIPPDETTTSIPTGTSPEQPTSTGTTPAAPVFTGAASVDRFGSPLAGVMAIAAIVLAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B4F9</accession>
    <accession>C8V7W9</accession>
    <name>Q5B4F9_EMENI</name>
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        <recommendedName>
            <fullName evidence="5">DNA replication checkpoint mediator MRC1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="6" type="ORF">ANIA_04571</name>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF77232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_662175.1">
        <property type="nucleotide sequence ID" value="XM_657083.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B4F9"/>
    <dbReference type="STRING" id="227321.Q5B4F9"/>
    <dbReference type="GeneID" id="2872373"/>
    <dbReference type="KEGG" id="ani:ANIA_04571"/>
    <dbReference type="eggNOG" id="ENOG502QSP5">
        <property type="taxonomic scope" value="Eukaryota"/>
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</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B518</accession>
    <accession>C8V8Y1</accession>
    <name>Q5B518_EMENI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_04362</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
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            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
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        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
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        <property type="entry name" value="Vaccinia Virus protein VP39"/>
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        <property type="entry name" value="SAM-dependent_MTases_sf"/>
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        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <begin position="171"/>
            <end position="195"/>
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    </feature>
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        <source>
            <dbReference type="EMBL" id="CBF77680.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
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    </evidence>
    <sequence length="353" mass="38787" checksum="84A100C86B3B3636" modified="2005-04-26" version="1">MKLSILRRSKSTISASSVYGLDHAVLNIPVPPPTMWMNLGYWKPRPNKPDRQQDTTDFPTACAALLDQVLITASLLDENGDANPQPPEKKIRLLDVGIGCGDQSMRILGYKRGTGPGMHRCEAETAEQDGAGDAKDSTSPKKPLFDSYVGITSIPVQAQFAKQRVERLEKENRRAFSLSSSPSPSEKGEDKGLTPSNRAQVFCADAANPSSWSPELKASLPPAPAQQIEENWLLALDTLYHFSPSRFPLLKYAHSTLQASLMAFDLLLPTPKPSLWTRLLLRILCLLTGTPYTNFLTEDEYTALLVEAGYDLSDISFRDISGDVFSGIAGYINSREEVLKGYGLGGDILKLRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="114" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B5M6</accession>
    <accession>C8V4X7</accession>
    <name>Q5B5M6_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Putative phospholipase</fullName>
            <ecNumber evidence="4">3.1.1.47</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ANIA_04154</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphocholine + acetate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17777"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:30909"/>
            <dbReference type="ChEBI" id="CHEBI:36707"/>
            <dbReference type="EC" id="3.1.1.47"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the serine esterase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.47" evidence="4"/>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF74595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_661758.1">
        <property type="nucleotide sequence ID" value="XM_656666.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B5M6"/>
    <dbReference type="STRING" id="227321.Q5B5M6"/>
    <dbReference type="ESTHER" id="emeni-q5b5m6">
        <property type="family name" value="PAF-Acetylhydrolase"/>
    </dbReference>
    <dbReference type="GeneID" id="2873573"/>
    <dbReference type="KEGG" id="ani:ANIA_04154"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN4154"/>
    <dbReference type="eggNOG" id="KOG3847">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022501_3_0_1"/>
    <dbReference type="InParanoid" id="Q5B5M6"/>
    <dbReference type="OMA" id="KYWEVHV"/>
    <dbReference type="OrthoDB" id="2363873at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003847">
        <property type="term" value="F:1-alkyl-2-acetylglycerophosphocholine esterase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000594">
        <property type="entry name" value="Putative phospholipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016715">
        <property type="entry name" value="PAF_acetylhydro_eukaryote"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10272:SF11">
        <property type="entry name" value="PHOSPHOLIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10272">
        <property type="entry name" value="PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03403">
        <property type="entry name" value="PAF-AH_p_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018169">
        <property type="entry name" value="PAF_acetylhydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 4" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="3 4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="348"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="371"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR018169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR018169-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBF74595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="531" mass="58405" checksum="55BAD09D87837071" modified="2005-04-26" version="1">MSRDRTLSPPGEALELEPLVTSDDEQPDSPLAMQPPAPPRPRWLTDTRRRHWLSSAAALSARLLRPRLTWRYLLFSIFCLYALYCLVRGSPLLASPLPSYAGPYGVGAIDLEVPLAGGPLRVAEGVIKSTGQPAFEVETLLATIYYPTDRGFRSRKPRYPWIPRPISLTAKGYARLAHADNFLTRPIFTFVLWAVGGPITIPAEVDAPLLSSDKGLEAFPVTVFSHGDASSRTDYTHFLGELASRGHVLVAIEHRDGSGPGTIVKTSAGSPGRQVLPFRFSDLATDLDADSFKRAQLAFRDAEIHAAIELLHIIGKGALVHNTRDPVTTLTSWAGRLNLTQLTIAGHSFGATGALQALTNSDAPAAGLILDPGKSSGPLNPNATVPILVVHSNTWSRTVSLFYNRPHFDTVRDLVRAIPAPSWFLTSIGTAHPSVTDAPLLEPLILSWTTGATLDVKEALREYVRVAQDFSLFVRSGERRGILKEKTTHHQYGVWVDEERKKEFPKELARYWEVHVTPEDQEKPLEKPVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="127" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B5R2</accession>
    <accession>C8V517</accession>
    <name>Q5B5R2_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Zn(II)2Cys6 transcription factor (Eurofung)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ANIA_04118</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF74669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_661722.1">
        <property type="nucleotide sequence ID" value="XM_656630.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B5R2"/>
    <dbReference type="FunCoup" id="Q5B5R2">
        <property type="interactions" value="165"/>
    </dbReference>
    <dbReference type="GeneID" id="2873532"/>
    <dbReference type="KEGG" id="ani:ANIA_04118"/>
    <dbReference type="eggNOG" id="ENOG502QQ7I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019691_1_0_1"/>
    <dbReference type="InParanoid" id="Q5B5R2"/>
    <dbReference type="OMA" id="WTSYDLG"/>
    <dbReference type="OrthoDB" id="9986881at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009410">
        <property type="term" value="P:response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052478">
        <property type="entry name" value="Metabolite_Synth_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31779">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G17430)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31779:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="14"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="499"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBF74669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="559" mass="61281" checksum="8337E05C36434F21" modified="2005-04-26" version="1">MTSVPLKRKRARVACEPCRSRKRKCDGAAPCETCRDWGYDCYYAAGRSSKHNAGASPSEPPPGGSGLGGDSHRLAVDPQRVARGLTANSSAVFVRKMGLKVDPANAPRVNLFAWNVGARRLSSGLVPAPAGLPLVDLVPLGSMRQLAEIYFSKVDPCYGFIDRQVFLQRLDARWSSSGSGRSGIYDSVLAGVAALGLLFSERSASATELQLIENAKSILESYDGYAPPSLDLITGWVLHVVYMRMTAAPYSTWLASSTIMHLIEAAGLQHENPSTAYDPDIRRRLVGVALHQNMWPSYDIGLSRVQVKADLMQFTDVRSKPGDYTAELLGLLPISARLDPEETDADGDSDVHLHQSLLETLDRTHTQPPSILAQTNLVLCILRRLNLLNISTSPALPDRILSLFQRALQSARSMLTACCPWQHIANVPFHIITILLEMDTRSSLELLPEAVQTVKMVASIYNTPTMREAYTTARFLVFVYQQRRSRDVRLLTSVLDANGQPGTELEPGRAASDGMQPALPRPSPNLGEMPLLEGLVADMSELQELDFDQFLSLDTLRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B5S3</accession>
    <accession>C8V5A0</accession>
    <name>Q5B5S3_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter, putative (AFU_orthologue AFUA_4G00120)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ANIA_04107</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF74692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_661711.1">
        <property type="nucleotide sequence ID" value="XM_656619.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B5S3"/>
    <dbReference type="FunCoup" id="Q5B5S3">
        <property type="interactions" value="64"/>
    </dbReference>
    <dbReference type="GeneID" id="2873528"/>
    <dbReference type="KEGG" id="ani:ANIA_04107"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_2_1_1"/>
    <dbReference type="InParanoid" id="Q5B5S3"/>
    <dbReference type="OMA" id="FWMANRL"/>
    <dbReference type="OrthoDB" id="1935484at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000106">
        <property type="entry name" value="MFS transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF65">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="200"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="268"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="383"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="413"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="516"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBF74692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="575" mass="65905" checksum="D5499D97F103ABDF" modified="2005-04-26" version="1">MAEAVSNKETIVVGESSKDSTDSPTPSRRKTLQPQAVNVKPPQPAIASFFSFSKRYRDRCDPEEIATPPSVYDDPKLAPYFQPNPKYENLHRFDPAFRWTWGEEKPLIRKIDWKVTVWAALAFFALDLDRSNISQANTDSFLDDMGLDTNDYNLGQTLFKVAFLLAELPSQLVSKKVAQMCLWSIASAAQFWLNSRASFLALRVIIGVLQGGFIPDIILYLSYFFKSDELPLRLAIFWMANRLTDVVSPLIAYGVLHMRGTQGQEGWRWLFLIEGLLTLLIGIWSIFQMAPSPTQTKALWRPNGWFSEHEEKIMVNRILRDDPSKGDMHNREAITPKLLWRSLCDYDLWPIYAIGLTFGIPPAPSDQYLTLTLRGLGFDTFESNLLSIPAQIFTTINVFLSSFKPNVKWNQRAFLGLFTQFWFLPCLIALAVLPEGTPRWGSYALVTVILSYPTPHPMQVGWCSSNSNTVRTRTVSAALYKAGTDESSMMVQIQSIISSNIYREDDKPLYRRGNRVLIAINCLNFVLYLFAKWYYQQRNKKRDAVWNRMSSEEKEEYLNITTDQGNKRLDFRFAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B604</accession>
    <accession>C8V5P0</accession>
    <name>Q5B604_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Zn(II)2Cys6 transcription factor (Eurofung)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ANIA_04026</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF74860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_661630.1">
        <property type="nucleotide sequence ID" value="XM_656538.1"/>
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    <dbReference type="AlphaFoldDB" id="Q5B604"/>
    <dbReference type="STRING" id="227321.Q5B604"/>
    <dbReference type="GeneID" id="2873447"/>
    <dbReference type="KEGG" id="ani:ANIA_04026"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN4026"/>
    <dbReference type="eggNOG" id="ENOG502SJ37">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019186_0_0_1"/>
    <dbReference type="InParanoid" id="Q5B604"/>
    <dbReference type="OMA" id="ARACFAN"/>
    <dbReference type="OrthoDB" id="5425448at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052973">
        <property type="entry name" value="Fungal_sec-metab_reg_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35392:SF4">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35392">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="443"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="36"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="338"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="407"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="346"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBF74860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="796" mass="89040" checksum="77E31F53A1CCBAEA" modified="2005-04-26" version="1">MDCESAQSAAGIDPKILDSYQSDTVFTIPWENSGYERPLDWDTSQDSNHSDSEFADLSGSTGLLGQPGDYHSDDCSSKHATSPDKFGLADASVEGTLSSTVSPKTLPSADDNFQLDESWPPLQMFNNMMAGFPMEGSLLYSYAKEPASADAFIVEDGSAIPRGQGLSDISSDHFMPFQSISHAFPFTNESWAEPLASIESMPRQAPVAVGMGPQQVNRGSKHGDGYQNTIQFLETRWLDSLESQLPSNMTSPSSFSTFPQRPIIIKDEVTGQDMFQYKSENSSVSDDIPGTYDFYSATGDDVPAFADRQLDEEWKLEKNEASLEDSNEPQTATAFAVSEDPETLFSSVPSSSRASPLTTQRPSARPQPLAVQSAAIKKRKKRTSIVALNQDSHKPLQIVQEDGQGGSIASADFVSPPRGARRKGPLTMAGRANAGMRRKNKDTCVQCRLNKRKCDGNAPCEACRPTLHEQPCARACFSSIVEYGTCNYISQRAINHPTLDKSGRVRLNIPSEFDLNDLLSFLGERQGKFNIRASQAWGSLYVLDLGETYKFLRGLSEYNGNSRSNFLEFIDRRIVESKDKSKNWLTCVKDCDPMRNIYTLLSQWNNMPSRASYSFIPLDAGSEEKPMDVRNPEHQREILLAAQLSRIVCRMLEVEGFRKLERDFYNIKWKQISQETHMNFLKELGHILLTLRWRVSWWKRLGDGGREPDPTKQHYVERVDLLCRILYVYYTCVLAKLPSWCASEVPKGIWSTYADAENPVWDDFPVDPTDDGFKAWIERGAELIEQSGAPVRVAKI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-08-16" modified="2026-01-28" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B6U6</accession>
    <name>ATG9_EMENI</name>
    <protein>
        <recommendedName>
            <fullName>Autophagy-related protein 9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">atg9</name>
        <name type="ORF">AN3734</name>
    </gene>
    <organism>
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Phospholipid scramblase involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome. Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through atg2 from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion. Required for mitophagy. Also involved in endoplasmic reticulum-specific autophagic process and is essential for the survival of cells subjected to severe ER stress. Different machineries are required for anterograde trafficking to the PAS during either the Cvt pathway or bulk autophagy and for retrograde trafficking.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine(in) = a 1,2-diacyl-sn-glycero-3-phosphocholine(out)</text>
            <dbReference type="Rhea" id="RHEA:38571"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) = a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out)</text>
            <dbReference type="Rhea" id="RHEA:38663"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out)</text>
            <dbReference type="Rhea" id="RHEA:38895"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate)(in) = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate)(out)</text>
            <dbReference type="Rhea" id="RHEA:67920"/>
            <dbReference type="ChEBI" id="CHEBI:58088"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotrimer; forms a homotrimer with a central pore that forms a path between the two membrane leaflets.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Preautophagosomal structure membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">Forms a homotrimer with a solvated central pore, which is connected laterally to the cytosol through the cavity within each protomer. Acts as a lipid scramblase that uses its central pore to function: the central pore opens laterally to accommodate lipid headgroups, thereby enabling lipid flipping and redistribution of lipids added to the outer leaflet of atg9-containing vesicles, thereby enabling growth into autophagosomes.</text>
    </comment>
    <comment type="PTM">
        <text evidence="2">Phosphorylated by atg1. Atg1 phosphorylation is required for preautophagosome elongation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ATG9 family.</text>
    </comment>
    <dbReference type="EMBL" id="AACD01000061">
        <property type="protein sequence ID" value="EAA59942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BN001302">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B6U6"/>
    <dbReference type="SMR" id="Q5B6U6"/>
    <dbReference type="FunCoup" id="Q5B6U6">
        <property type="interactions" value="214"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5B6U6"/>
    <dbReference type="HOGENOM" id="CLU_006200_1_1_1"/>
    <dbReference type="InParanoid" id="Q5B6U6"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034497">
        <property type="term" value="P:protein localization to phagophore assembly site"/>
        <property type="evidence" value="ECO:0000318"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007241">
        <property type="entry name" value="Autophagy-rel_prot_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13038">
        <property type="entry name" value="APG9 AUTOPHAGY 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13038:SF10">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04109">
        <property type="entry name" value="ATG9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0072">Autophagy</keyword>
    <keyword id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword id="KW-0333">Golgi apparatus</keyword>
    <keyword id="KW-0445">Lipid transport</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000119831" description="Autophagy-related protein 9">
        <location>
            <begin position="1"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="5">
        <location>
            <begin position="1"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="5">
        <location>
            <begin position="193"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="5">
        <location>
            <begin position="237"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="intramembrane region" evidence="1">
        <location>
            <begin position="313"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="5">
        <location>
            <begin position="334"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="411"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="5">
        <location>
            <begin position="432"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="447"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="5">
        <location>
            <begin position="468"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="intramembrane region" evidence="1">
        <location>
            <begin position="514"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="5">
        <location>
            <begin position="535"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="59"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="711"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="67"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="114"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="O74312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="Q12142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3"/>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <sequence length="820" mass="92456" checksum="E78CBE755863D49A" modified="2005-04-26" version="1">MMASNVLSRLLPQTGQSVYETIRQHDNDSDASDVEERAGLVYDDDVNLGNRFSDRELEEAMADATREGSSSPSDTFLTPQIAQRGERSASSGPRMRKPNNPRFMRSVTPRPEFVEDDLDDDHDDDVPASLLMEGQHDDEYLRTRLPPPPSHHFSDPQPSRSARSPRREHIRTFAFVVGFTTFLTNCIDYRLVRTSKSLDQILISKCTSRMSASSTFLLWLLCLFWIGKIFQLILDIRRLKNMHDFYHYLLGVSDAEIQTISWQEVVSRLMTLRDANPATAGAVSAFNRRLLGSQSKQRMDAHDIANRLMRKENYLIALINKDILDLTLPIPFLRNRQLFSRILEWNINLCIMDYVFNEQGQLSSRQYTPLAEWKFREFNELWHLFEKRINLSYPYATRYVDQFPKDKTVQVAGFVAFISGALASVLALASILDPELFLGFELTHDRTTLFYLGVFGSVWAFARGMVPEETLVFDPEYALLEVIQFTHYFPSHWKGKLHSDDVRREFAVLYQMKIIIFMEEILSMIFTPFILWFSLPKCSERVIDFFREFTVHVDGMGYLCSFAVFDFKKGTNVIPQGHINQRDARQDPRVDYFSTKDGKMLASYYGFLDNYGGNPRATNANKRAFHPPPTFPSLGSPPFVGASNIGNRQDPIQARVNTASAALGQQSMLGATRLGALGVGDTQSPAPSLLLDPQHQPSASGFRATNHIAPHHRQRLGRPPPAPVSESIIDDNEPSIAAARRPAPRRKSGQLHTNSGSSEALGAGDSNVEDSWGMKSGGEVNDEDAEENVDDVVGGAGVLGLIQQFQKVNKDNRPRAAVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="105" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B751</accession>
    <accession>C8V446</accession>
    <name>Q5B751_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Formamidopyrimidine-DNA glycosylase, putative (AFU_orthologue AFUA_4G11930)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">ANIA_03629</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of DNA containing ring-opened 7-methylguanine residues, releasing 2,6-diamino-4-hydroxy-5-(N-methyl)formamidopyrimidine.</text>
            <dbReference type="EC" id="3.2.2.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FPG family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF75741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_661233.1">
        <property type="nucleotide sequence ID" value="XM_656141.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B751"/>
    <dbReference type="STRING" id="227321.Q5B751"/>
    <dbReference type="GeneID" id="2873052"/>
    <dbReference type="KEGG" id="ani:ANIA_03629"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN3629"/>
    <dbReference type="eggNOG" id="ENOG502QVDB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038423_0_1_1"/>
    <dbReference type="InParanoid" id="Q5B751"/>
    <dbReference type="OMA" id="EKFPEHW"/>
    <dbReference type="OrthoDB" id="444592at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019104">
        <property type="term" value="F:DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003906">
        <property type="term" value="F:DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008534">
        <property type="term" value="F:oxidized purine nucleobase lesion DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd08972">
        <property type="entry name" value="PF_Nei_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.50:FF:000009">
        <property type="entry name" value="Formamidopyrimidine-DNA glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.190.10:FF:000004">
        <property type="entry name" value="Putative Formamidopyrimidine-DNA glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.190.10">
        <property type="entry name" value="MutM-like, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012319">
        <property type="entry name" value="FPG_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035937">
        <property type="entry name" value="FPG_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015886">
        <property type="entry name" value="H2TH_FPG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_uS13-like_H2TH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22993">
        <property type="entry name" value="FORMAMIDOPYRIMIDINE-DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22993:SF9">
        <property type="entry name" value="FORMAMIDOPYRIMIDINE-DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01149">
        <property type="entry name" value="Fapy_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06831">
        <property type="entry name" value="H2TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00898">
        <property type="entry name" value="Fapy_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01232">
        <property type="entry name" value="H2TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81624">
        <property type="entry name" value="N-terminal domain of MutM-like DNA repair proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="S13-like H2TH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51068">
        <property type="entry name" value="FPG_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Formamidopyrimidine-DNA glycosylase catalytic" evidence="11">
        <location>
            <begin position="2"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="285"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="299"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="318"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="354"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CBF75741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="363" mass="41521" checksum="C50A46D515B0E608" modified="2005-04-26" version="1">MPELAEIYRIVHFIRQHLVGKTLAKVSTQHDDIVYGKVGTSAAEFQKAMEGKKVIGTGQQGKYFWITMTSPPHVVMHFGMAGWLKIRDADTYYYRTDKPEDKQWPPKYWKFLLETDGDPKVEAAFVDFRRLARIRLVDCPAEEIRNYTPLKENGPDPLVDKDVVTKEWLGSKLSSKKVPVKALLLDQAVISGIGNWMGDEILYHAKIHPEQYSNTLTDDQVKELHSSIHYVCSTSTEVLADSDKFPEHWLFKHRWSKGKKNKQSSLPNGEKITFLTVGGRTSAVVPSVQKKTGPVAGDVKQEDESSDERQTKRKRTTTKKDTSKTDKIDSRKESKQSVKLEDEDALEDKDTRQTNRRSTRLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="150" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B756</accession>
    <accession>C8V451</accession>
    <name>Q5B756_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">P-type Cu(+) transporter</fullName>
            <ecNumber evidence="3">7.2.2.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Cu(2+)-ATPase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">ANIA_03624</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="22" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="22">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="18">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 18">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.8" evidence="3"/>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF75750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_661228.1">
        <property type="nucleotide sequence ID" value="XM_656136.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B756"/>
    <dbReference type="FunCoup" id="Q5B756">
        <property type="interactions" value="438"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5B756"/>
    <dbReference type="GeneID" id="2873047"/>
    <dbReference type="KEGG" id="ani:ANIA_03624"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN3624"/>
    <dbReference type="eggNOG" id="KOG0207">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001771_0_1_1"/>
    <dbReference type="InParanoid" id="Q5B756"/>
    <dbReference type="OMA" id="HWMLPAW"/>
    <dbReference type="OrthoDB" id="432719at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043682">
        <property type="term" value="F:P-type divalent copper transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140581">
        <property type="term" value="F:P-type monovalent copper transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055070">
        <property type="term" value="P:copper ion homeostasis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043324">
        <property type="term" value="P:pigment metabolic process involved in developmental pigmentation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="CDD" id="cd02094">
        <property type="entry name" value="P-type_ATPase_Cu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000001">
        <property type="entry name" value="ATPase copper transporting beta"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000002">
        <property type="entry name" value="Copper-transporting ATPase 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017969">
        <property type="entry name" value="Heavy-metal-associated_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006122">
        <property type="entry name" value="HMA_Cu_ion-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00003">
        <property type="entry name" value="copper ion binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43520">
        <property type="entry name" value="ATP7, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43520:SF8">
        <property type="entry name" value="P-TYPE CU(+) TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00942">
        <property type="entry name" value="CUATPASEI"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="HMA, heavy metal-associated domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01229">
        <property type="entry name" value="COF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01047">
        <property type="entry name" value="HMA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0186">Copper</keyword>
    <keyword evidence="9" id="KW-0187">Copper transport</keyword>
    <keyword evidence="15" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="16 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="12" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="378"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="412"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="453"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="482"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="664"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="705"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1049"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1078"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="20">
        <location>
            <begin position="24"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="20">
        <location>
            <begin position="115"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="20">
        <location>
            <begin position="205"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="20">
        <location>
            <begin position="286"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00080126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU362081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="CBF75750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="1182" mass="124212" checksum="6A62938C652F0FBA" modified="2005-04-26" version="1">MAVSNTLAARGGALSPSQTTSQMATTTVSVEGMTCGACTSAVEGAFNGVEGAGEVSVSLMMSRAVIHHDPTLLPPGKVAEIIEDCGFDATVISTDSSSIPSRSASDHGASEANVVTTTLAVAGMTCGACTSAVESGLAENPGVRSVNVSLLSERAVIEHDLSTVSAEQLAEIVEDRGFGARVLETSTSRAGPRGSESTDPSSQSMTTTVAIEGMTCGACTSSVQAAFDGVEGVIQFNISLLAERAIITHNPQILPSRKIVEIIEDAGFDAKVVSEVQALGQKGGPTQVTLDVHGLRDANSAAALEDSLMQKPGIISASVTLATSRLVVSYDTSMVGIRTIVAVIEAAGCNALLADSDDKNTQLESLAKTKEVLEWRRAFLFSLSFAIPVFLINMILPMYLPTLDFGGIRIIPGLYLGDSVCLLLTIPVQFGIGKRFYITSYKSLRHRAPTMDVLVMLGTSAAFFYSVFTMIVAIVIDPHQRPNTVFDTSTMLITFITLGRWLENRAKGQTSAALSRLMSLAPSMTTIYDDPIAAEKMVEEWDKVDGQEQKTATNEMSTVSQKIIPTELIEVGDIVVLHPGDKVPADGVVIRGETYVDESMITGEALPIHKAKGSLVIAGTVNGTSAVDIKVIRTGKDTQLSKIVKLVQDAQTSRASIQRMADIVAGYFVPSIISLGLVTFFGWMFVSHLLPHPPKIFVTKEGGGKVMVCLKLCISVIVFACPCALGLSTPTAVMVGTGVGATQGILVKGGAVLEAATKITHVVYDKTGTLTTGQMSVTEARIEPHWSSSDWRRRLWWLIVGLAEMNSEHPIGKAIHLAAKSESGNSGEGGLPGSLGDFEARIGKGIAALVEPASGVERVRYRVLIGNAAFLQSHSVAVPESAETTPDASGYKNSRVGITQIHVAIDGHFAGTIALQDTVKVTAVAAVAALHRMGISTSLITGDSRAAAISIASAVGIAPEAVHASVSPSDKQSIIASLQETGDRVAMVGDGINDSPALATASVGIALASGTDVAMEAADIVLMRPDDLLSVPASLALSRSVFNRIKLNLVWACGYNIIGLPFAMGLFLPFGGFMLPPMAAGAAMALSSVSVVVSSLLLKFWRRPSWMDAELLEKEVGIASDGNSRKNWLGATLFTSPNKTRRAAQWAQGIGARVWSVFTGRPSQSASIEPSYVPLQTVEPAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B7J1</accession>
    <accession>C8V552</accession>
    <name>Q5B7J1_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">ER transporter 6TM N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ANIA_03489</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF76050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_661093.1">
        <property type="nucleotide sequence ID" value="XM_656001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B7J1"/>
    <dbReference type="STRING" id="227321.Q5B7J1"/>
    <dbReference type="GeneID" id="2872913"/>
    <dbReference type="KEGG" id="ani:ANIA_03489"/>
    <dbReference type="eggNOG" id="KOG4711">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003918_1_0_1"/>
    <dbReference type="InParanoid" id="Q5B7J1"/>
    <dbReference type="OMA" id="DTHIPSY"/>
    <dbReference type="OrthoDB" id="2274698at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018823">
        <property type="entry name" value="ArAE_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018820">
        <property type="entry name" value="BRE4-related_DUF2421"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049453">
        <property type="entry name" value="Memb_transporter_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37994">
        <property type="entry name" value="ARAE_2_N DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37994:SF3">
        <property type="entry name" value="ER TRANSPORTER 6TM N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10337">
        <property type="entry name" value="ArAE_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10334">
        <property type="entry name" value="BRE4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13515">
        <property type="entry name" value="FUSC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="151"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="180"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="602"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="631"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="654"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="680"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="706"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="747"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="domain" description="Putative ER transporter 6TM N-terminal" evidence="8">
        <location>
            <begin position="17"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="Integral membrane bound transporter" evidence="9">
        <location>
            <begin position="616"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2421" evidence="7">
        <location>
            <begin position="765"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="337"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="543"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="337"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBF76050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="978" mass="107910" checksum="32B4000A64166655" modified="2005-04-26" version="1">MADRALDGKAGSGRKRRLPAFLDHFSARELKIFFRCWVAVWVASLLIFIDPVATDFGQATFFACMVLFFLPPAGVLFVYILGALSLFVGICLAWAWGVIAMKAALAARPGAETQARVGALQQAAAAEAQETGASASSIAQRLVYNGWMLDARVTVIFYCMLCLFIYFMARLRAANPKATLTSIFGIIIIDMFLCYGPILTSFNGTLPLPLVKPSATAVGLGAVCSIIFFPRSTSDIILEDMQGLLELLKSSLQLSYSALGRSSDQLGPQQLQKWRMKIIAHYRTLEPSFGFLPLDFHIGSWGAEVVTTFREPVRHLVAAILTLSEFHKETVEKRIQTQELELKDPSIHQHEDGTDEKKDRKVGAHHRSQLAELIQGLQYTQHHSIPEDVASEFISLSSNAMEACLDGLSVIGECLQFVDRQRWYHKAPSAAHEELQERTKTVLERLLQTRAAFLADMTESLVRAYGPILDKPDHHNHANQADQLAGIIICMNFQEHMANTMDKTGALLSSMSSALPKASRTRFYVPTSLKYAGRWLVGKKDKAPVMAPTNDDSPAQDPAGDATQTAQEKLRVRRGYRPRTRHPLGKAILGTYHWLTCDEGLFALRMVVVTIAVSIAAVLPNTAGFFYRERGLWALIMSQTGLLVYMADFTFAVLTRLIGTVAGGVLGLLAWYIGSGHGPGNPYGLSAALAVLLAIFLWVRLYLPPVFLQGGIMSAATFLLVVAYSYVDTHNPAYGNPGVGYQVFWRRLLLVLIGVAAAIIVQILPRPPSAARHVCSSLSRSLRTLSDHYALLLSCWGRVGDEGRAITEPIWLELTESLVLLEGPIFNLRFEFSSSRFDSESLGQVKQICHTINGLLARLLVASASLPQAYKDRLSNHMGMLDHRRIGEIMAVLGVAEQSLRTGDAPPEILPTPLVRRALEHWQTQTLLDEYAVLDAEMIRDENYRSYCVALAAYISFLGKIDELVLVVKGVLGEAHLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B7K4</accession>
    <accession>C8V565</accession>
    <name>Q5B7K4_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ANIA_03476</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF76075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_661080.1">
        <property type="nucleotide sequence ID" value="XM_655988.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B7K4"/>
    <dbReference type="STRING" id="227321.Q5B7K4"/>
    <dbReference type="GeneID" id="2872894"/>
    <dbReference type="KEGG" id="ani:ANIA_03476"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN3476"/>
    <dbReference type="eggNOG" id="ENOG502SQW0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047271_0_0_1"/>
    <dbReference type="InParanoid" id="Q5B7K4"/>
    <dbReference type="OMA" id="HTDEGAC"/>
    <dbReference type="OrthoDB" id="3852249at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046486">
        <property type="entry name" value="DUF6579"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20219">
        <property type="entry name" value="DUF6579"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF76075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="463" mass="51256" checksum="32186D69BD3B7762" modified="2005-04-26" version="1">MSLGYGYDAELWQFSQQVYPDLPPIEAYLAFHRDYVAPMVRPVINGTLTLAEIVALFRKPTSPIARIHGLRLAGLVAERLYDHIKRLFRTPQATVSNITAGEKEISALLTAGIWKQYKAGTLSQLDPFPDGVDMAAAGASVSSENVKKVPKDITDYAASGAFAGSGRTESLLDRINYLECWNTALRMIQTLQAQHMIKSLKVIADHLGDRNCIAVMGAGGPDGFARPIYDLIKMKISDIDRAGLKNHRFFVYHDSNYWHPAFKRLTSENPLPSEFVNNPCDDLDHACLFMREVRQKLLAKDENQGKDIKFHLLIPTWSKLQIKEPLHFPEDLYPLQIEGLKHGGKDQVELNLPAAPAGLLHGVTNTLDPNNWNKIARGTSEAVTLPAVGWGVNGACLATSLCVGSLTPLGPLLAIPLWIVSARTAMEKSAPVIYETIHEALCEEDPRVLGSKERLHMPLRHGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="120" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B7P6</accession>
    <accession>C8VHI5</accession>
    <name>Q5B7P6_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RAS small monomeric GTPase, putative (AFU_orthologue AFUA_3G05770)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_03434</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF82716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_661038.1">
        <property type="nucleotide sequence ID" value="XM_655946.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B7P6"/>
    <dbReference type="STRING" id="227321.Q5B7P6"/>
    <dbReference type="GeneID" id="2873863"/>
    <dbReference type="KEGG" id="ani:ANIA_03434"/>
    <dbReference type="eggNOG" id="KOG0395">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041217_9_2_1"/>
    <dbReference type="InParanoid" id="Q5B7P6"/>
    <dbReference type="OMA" id="DMVNIEE"/>
    <dbReference type="OrthoDB" id="265044at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001856">
        <property type="entry name" value="RAS small monomeric GTPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF82716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="197" mass="21856" checksum="6B5507E673BEB94A" modified="2005-04-26" version="1">MGDAPNKISITICGDGGCGKSSITLRLVRSEWVHEYDPTIEDSYSVSRTIDGEQYFLSITDTAGQEEYRGLWAASNLKSDAFLLVYDITSKSSLSALDYFMDMIEMEADQRAEDNLRLMRELGDSARGVEFGMAAPVKIVAGNKCDLKDSRVISAKDGLEYARKHNSGFMETSAREMVNIEETFARADPSRFSKCAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="131" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B7U5</accession>
    <accession>C8VHN7</accession>
    <name>Q5B7U5_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Zn(II)2Cys6 transcription factor (Eurofung)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ANIA_03385</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF82814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_660989.1">
        <property type="nucleotide sequence ID" value="XM_655897.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B7U5"/>
    <dbReference type="GeneID" id="2874070"/>
    <dbReference type="KEGG" id="ani:ANIA_03385"/>
    <dbReference type="eggNOG" id="ENOG502SH49">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011017_3_1_1"/>
    <dbReference type="InParanoid" id="Q5B7U5"/>
    <dbReference type="OMA" id="RRPQCQV"/>
    <dbReference type="OrthoDB" id="3037908at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF3">
        <property type="entry name" value="C6 FINGER DOMAIN TRANSCRIPTION FACTOR DBAA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="19"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="114"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBF82814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="509" mass="58419" checksum="B97AE9492F55387B" modified="2005-04-26" version="1">MKTETPPVTVTSRQRPGSACEECRRRKVRCDRQRPQCQVCYEGGLDCKISTTRLPRGPRKGQLRTLRTRIGRLLNVKSSKTLAERVAALERCLADRHPEIDRQMHSLLEGAGVEYDSEDSSRGQNLSRDGTESPRDRREGTKSQLHDFPRSELVTELMRADLDQLYFDRVHPFAPILQRWRYHVWSQQQQKSDGQACLQHAMWTVAASLSAQFRSLRDPLYQETRRMLDMLDSQNSYSRPDASGGIEHAQAWVLVCIYEYMQLSQLQAWMSAGRCCRLVLGMRLYELDDPNSPVMMAKDQETSLIDWTGLEERRRTFWMAYSLDRFISFHNGLPFTLNEQLIATRLPGPEEDFQAGNPVVTQYLPEAMTRTSNDPIQPISSFSECIILATICGRALAHRQKVAVEQLSITGDVATFEGFWSRHQWLHEMLNSRIRMLSACAQVDPMLMFARIVAQTMVLFLHSVLESITWKTGDHLLGIIEYERLCVMAAQEVVNLVKLQGQLGYFKVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B844</accession>
    <accession>C8VI16</accession>
    <name>Q5B844_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_03286</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
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                <person name="Liu B."/>
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                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
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                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
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                <person name="Ussery D."/>
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        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
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                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
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                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
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                <person name="Fischer R."/>
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                <person name="Dyer P."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
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    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
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                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
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                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
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                <person name="Klis F.M."/>
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                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
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                <person name="Meyer V."/>
                <person name="Mirabito P."/>
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                <person name="Paszewski A."/>
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                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
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                <person name="van de Vondervoort P.J."/>
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                <person name="Cornell M.J."/>
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            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
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        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
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                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
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                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
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                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
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                <person name="Purcell S."/>
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                <person name="Draht O."/>
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    <reference evidence="5" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
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                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAH family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF83727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_660534.1">
        <property type="nucleotide sequence ID" value="XM_655442.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B950"/>
    <dbReference type="FunCoup" id="Q5B950">
        <property type="interactions" value="476"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5B950"/>
    <dbReference type="GeneID" id="2874413"/>
    <dbReference type="KEGG" id="ani:ANIA_02930"/>
    <dbReference type="eggNOG" id="KOG1535">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028458_5_0_1"/>
    <dbReference type="InParanoid" id="Q5B950"/>
    <dbReference type="OMA" id="NCRKVIC"/>
    <dbReference type="OrthoDB" id="74910at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018773">
        <property type="term" value="F:acetylpyruvate hydrolase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050163">
        <property type="term" value="F:oxaloacetate tautomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006107">
        <property type="term" value="P:oxaloacetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.850.10:FF:000003">
        <property type="entry name" value="Fumarylacetoacetate hydrolase domain-containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="entry name" value="Fumarylacetoacetase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820">
        <property type="entry name" value="ACYLPYRUVASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820:SF7">
        <property type="entry name" value="ACYLPYRUVASE FAHD1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="FAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarylacetoacetase-like C-terminal" evidence="3">
        <location>
            <begin position="18"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBF83727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="229" mass="25456" checksum="5F19D04845A6ED83" modified="2005-04-26" version="1">MAASIKSNCRKLTLDRSDHIAELNNTKPKQPFFFLKPSSSILCPGEGPVLRPKGTSLHYEVELALVMGKKVRDLDPNDDKGALDAIQSYLLAIDMTARNVQDEAKKKGLPWTIAKGFDTFLPISQEILKSQIPDPHNAFLRLSVNSQQRQADSSGLMLYRIPRLLAEISRVMTLEKGDLVLTGTPKGVGEVKSGDVMKASIEVDGKEIEQGRIEVEVQDREGRYEYCET</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B965</accession>
    <accession>C8VJ66</accession>
    <name>Q5B965_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_02915</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF83755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_660519.1">
        <property type="nucleotide sequence ID" value="XM_655427.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B965"/>
    <dbReference type="STRING" id="227321.Q5B965"/>
    <dbReference type="GeneID" id="2874152"/>
    <dbReference type="KEGG" id="ani:ANIA_02915"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN2915"/>
    <dbReference type="HOGENOM" id="CLU_640975_0_0_1"/>
    <dbReference type="InParanoid" id="Q5B965"/>
    <dbReference type="OMA" id="KQWYVCS"/>
    <dbReference type="OrthoDB" id="5431298at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="CDD" id="cd12087">
        <property type="entry name" value="TM_EGFR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="364"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="368"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF83755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="428" mass="46227" checksum="06BFEB7291FC9C01" modified="2005-04-26" version="1">MSPSSTTEFESLTRDNAIKAATSSVTEKATITPTSTLSKLDAHPTPASNLVSSSHRLRSTMIGAIVGGVISLVLILCVIAYFIRRTRKQRGRVGRQFTLLRWRHRCLEEKQMDLEETGTTTGTIDFHAQAKGQPPLVRTQDVVIGSGSCTGFMSRQKQPQTILGEQSPVVSLIQKRETDLPDSIPSALTSSPSPLAALEPAMSPKTSFKLQFAFTPTPLLPAAIHPALHSGQGEHAYQPTAYWPSSCTPEMSRCSNTNIITNNDDAHADAHEQPHSRRPSTTPELFDTGFYLGRVELPTTCSRELINIPFAERQRQRQKSQLHRGTTHLLSITTPDGAVLSPNFNGLPVDTGTWPCRAETREEGIEGAEGNTEAETQAQAAAAKPASSAPAPAIAVASASDLKLAVFGAVVITDTVFIGLSWRGSRER</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="127" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B977</accession>
    <accession>C8VJ80</accession>
    <name>Q5B977_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">saccharopepsin</fullName>
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        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Aspartic endopeptidase PEP2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Aspartic protease PEP2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">ANIA_02903</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="21">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Vacuolar aspartic endopeptidase which is probably also secreted and contributes to virulence.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>Hydrolysis of proteins with broad specificity for peptide bonds. Cleaves -Leu-Leu-|-Val-Tyr- bond in a synthetic substrate. Does not act on esters of Tyr or Arg.</text>
            <dbReference type="EC" id="3.4.23.25"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 17">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.23.25" evidence="12"/>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF83780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_660507.1">
        <property type="nucleotide sequence ID" value="XM_655415.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B977"/>
    <dbReference type="FunCoup" id="Q5B977">
        <property type="interactions" value="392"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5B977"/>
    <dbReference type="MEROPS" id="A01.018"/>
    <dbReference type="GeneID" id="2873983"/>
    <dbReference type="KEGG" id="ani:ANIA_02903"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN2903"/>
    <dbReference type="eggNOG" id="KOG1339">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013253_3_4_1"/>
    <dbReference type="InParanoid" id="Q5B977"/>
    <dbReference type="OMA" id="KYDHDAS"/>
    <dbReference type="OrthoDB" id="771136at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005775">
        <property type="term" value="C:vacuolar lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097718">
        <property type="term" value="F:disordered domain specific binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070492">
        <property type="term" value="F:oligosaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016237">
        <property type="term" value="P:microautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000425">
        <property type="term" value="P:pexophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd05488">
        <property type="entry name" value="Proteinase_A_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000036">
        <property type="entry name" value="Vacuolar aspartic protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000002">
        <property type="entry name" value="Vacuolar aspartic proteinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033819">
        <property type="entry name" value="Saccharopepsin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 17" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="8 16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 17 20" id="KW-0645">Protease</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 18" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010241348" description="saccharopepsin" evidence="18">
        <location>
            <begin position="18"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="19">
        <location>
            <begin position="81"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="active site" evidence="15">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <feature type="active site" evidence="15">
        <location>
            <position position="283"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="112"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="317"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00052037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00055395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00067071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00079414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00079734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CBF83780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="394" mass="42800" checksum="505051D0E0115480" modified="2005-04-26" version="1">MKASLLTASVLLGYASAEVHKLKLNKVPLTEQFITRNIADHANALGQKYMGQFQQHVLEDEPVNAMRGHDVLVDNFMNAQYFSEIQLGTPPQTFKVVLDTGSSNLWVPSSECGSIACYLHQKFDSSASSTYKKNGSEFAIKYGSGSLSGFVSRDNLQIGDLKVKGQDFAEATSEPGLAFAFGRFDGILGLGFDTISVNRIVPPFYNMIHQGLLDEPVFAFYLGDANKDGDSSVATFGGIDKDHYEGELIKIPLRRKAYWEVDLDAIALGDEVAELENTGVILDTGTSLIALPSNLAEMINTEIGATKGFTGQYTIDCAKRDSLPDLTFTLTGHNFTIGPYDYTLEVQGSCISAFMGMDFPEPVGPLAILGDAFLRKWYSVYDLGNGAVGLAKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BBN4</accession>
    <accession>C8VLM2</accession>
    <name>Q5BBN4_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mediator of RNA polymerase II transcription subunit 20</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Mediator complex subunit 20</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">MED20</name>
        <name evidence="6" type="ORF">ANIA_02046</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the Mediator complex subunit 20 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF86073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_659650.1">
        <property type="nucleotide sequence ID" value="XM_654558.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BBN4"/>
    <dbReference type="STRING" id="227321.Q5BBN4"/>
    <dbReference type="GeneID" id="2874787"/>
    <dbReference type="KEGG" id="ani:ANIA_02046"/>
    <dbReference type="eggNOG" id="ENOG502SBIU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075636_0_0_1"/>
    <dbReference type="InParanoid" id="Q5BBN4"/>
    <dbReference type="OMA" id="PNHGFIY"/>
    <dbReference type="OrthoDB" id="1854899at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013921">
        <property type="entry name" value="Mediator_Med20"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08612">
        <property type="entry name" value="Med20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="296"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="105"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBF86073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="337" mass="37222" checksum="11B0FADE2C8670DC" modified="2005-04-26" version="1">MVVWLSLSIELMSASVFFIPSNPNAATALATVTERLTALFADEATPVSRWALEHKLMRDTPSCLPNSGTQRPGAPKYMQFLSLTYHPNHGFIYTSQQADKDGPGAVAAPTPSSSQSSQATSVTTPMVMTTVPLPSTGALYQHFSYACQPFWCHRHTVTVPNGVVYEIGDFRVRAGDVRQTQPAVRMRGTVVEIEWQGPSLATTLSGLYRSRRQKRRVASNTYMWDNEDGEDHDSGIDMAFPDGVEEADIDAEYAATAALIKEFWGKLEIEGAREAILVPDVGKEVKERLRKLKQPDKQGVSHVVNEDGSGLQVDEDPDPDAGVDVARQFMEIFRFNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BBP6</accession>
    <accession>C8VLG2</accession>
    <name>Q5BBP6_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_02034</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF86050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_659638.1">
        <property type="nucleotide sequence ID" value="XM_654546.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BBP6"/>
    <dbReference type="STRING" id="227321.Q5BBP6"/>
    <dbReference type="GeneID" id="2875073"/>
    <dbReference type="KEGG" id="ani:ANIA_02034"/>
    <dbReference type="HOGENOM" id="CLU_106738_1_0_1"/>
    <dbReference type="InParanoid" id="Q5BBP6"/>
    <dbReference type="OMA" id="TGDRSIM"/>
    <dbReference type="OrthoDB" id="2148716at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="CDD" id="cd00531">
        <property type="entry name" value="NTF2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13577">
        <property type="entry name" value="SnoaL_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="17"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF86050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="162" mass="17960" checksum="3A306B79A1BA4FC2" modified="2005-04-26" version="1">MVRNGTPLPAKLAGPPLSDREAIADACYRAFASIDHASEELLESSATPDIYTDIAFKECDGYEELRNKVWINVAEHVDTVHYISNVRVSIDTETTARVTFNAQAVHCIVGKGYEPDSTKFTTGAFYACDAVKVDDLWKLKTMRSTHIWSTGDRSIMKPPSSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="103" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BBX7</accession>
    <accession>C8VL25</accession>
    <name>Q5BBX7_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ANIA_01953</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the actin family. ARP1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF85886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_659557.1">
        <property type="nucleotide sequence ID" value="XM_654465.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BBX7"/>
    <dbReference type="STRING" id="227321.Q5BBX7"/>
    <dbReference type="GeneID" id="2875353"/>
    <dbReference type="KEGG" id="ani:ANIA_01953"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN1953"/>
    <dbReference type="eggNOG" id="KOG0676">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027965_0_2_1"/>
    <dbReference type="InParanoid" id="Q5BBX7"/>
    <dbReference type="OMA" id="YTTWTGG"/>
    <dbReference type="OrthoDB" id="5132116at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005869">
        <property type="term" value="C:dynactin complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001411">
        <property type="term" value="C:hyphal tip"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007097">
        <property type="term" value="P:nuclear migration"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030473">
        <property type="term" value="P:nuclear migration along microtubule"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="CDD" id="cd10216">
        <property type="entry name" value="ASKHA_NBD_Arp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000015">
        <property type="entry name" value="Actin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000018">
        <property type="entry name" value="Actin-like protein (Centractin)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBF85886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="380" mass="43055" checksum="08D940283FEC9AD6" modified="2005-04-26" version="1">MTEATLHNAPIVIDNGSGTIRAGFAGEEIPSCYFPSFVGRPKHPRVMAGGLEGDVFIGQRAQELRGLMKIRYPLEHGIVTDWDDMEKIWHYVYENELKTLPEEHPVLLTEPPLNPRKNRDIAAQIMFETFNVPALYTSIQAVLSLYASGRTTGVVLDSGDGVSHAVPVFEGFAIPNSIRRIDVAGRDVTEQLQLLLRKTGHVLHTSAEKEVVRMIKEKVCYVSLDPKREEKEWMNSYKSESKHADYVLPDGHKIKIGQERFRAPEILFDPELIGLEYPGVHQIVQDAIIRTDLDLRKSLYLNIVLSGGSTLCKNFPDRLMREIKRLAVEDMKIRISAPAERKYTTWIGGGILAGLSTFRKMWVSADEWHEDPEIIHRKFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BBY3</accession>
    <accession>C8VKW9</accession>
    <name>Q5BBY3_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Metallo-beta-lactamase family protein (AFU_orthologue AFUA_5G12770)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ANIA_01947</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF85876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_659551.1">
        <property type="nucleotide sequence ID" value="XM_654459.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BBY3"/>
    <dbReference type="STRING" id="227321.Q5BBY3"/>
    <dbReference type="GeneID" id="2875604"/>
    <dbReference type="KEGG" id="ani:ANIA_01947"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN1947"/>
    <dbReference type="eggNOG" id="ENOG502S0TT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047034_1_0_1"/>
    <dbReference type="InParanoid" id="Q5BBY3"/>
    <dbReference type="OMA" id="ICADERQ"/>
    <dbReference type="OrthoDB" id="17458at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36839">
        <property type="entry name" value="METALLO-BETA-LACTAMASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G12770)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36839:SF1">
        <property type="entry name" value="METALLO-BETA-LACTAMASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G12770)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF85876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="318" mass="35681" checksum="CFEB20FECD93965F" modified="2005-04-26" version="1">MPETSPSPQALDFLICSTCGTQYPTPSTLRSCKICDDPRQYVPPTGQSWTTLRALQNSQDPKYKNIFTPDTIHGESLISIHTEPKQAIGQRAYLCRTFSPGNSRLFNVLWDCITYIDDYTITRINELGGIDAIVISHPHYYTTHLVWAEIFDCPVYLSSEDEEWAVVKGDKQVFFGESSLSFAPSGNYGGDDGRADIIVLKTGGHFPGSTVLWWRPLKTLLIADTIAVVPSGRYWVDRPAGTASFTFMWSYPNMIPLSADDVHGIWKAIKHTEFDITRGAFIGMETDTDSKKRLLDSAQIFVKAMGYLDHAIHQEECH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="113" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BC80</accession>
    <accession>C8VPR3</accession>
    <name>Q5BC80_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Mitochondrial inner membrane metallopeptidase Oma1, putative (AFU_orthologue AFUA_4G09730)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ANIA_01850</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase M48 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF85685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_659454.1">
        <property type="nucleotide sequence ID" value="XM_654362.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BC80"/>
    <dbReference type="FunCoup" id="Q5BC80">
        <property type="interactions" value="219"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5BC80"/>
    <dbReference type="GeneID" id="2875739"/>
    <dbReference type="KEGG" id="ani:ANIA_01850"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN1850"/>
    <dbReference type="eggNOG" id="KOG2661">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029002_1_2_1"/>
    <dbReference type="InParanoid" id="Q5BC80"/>
    <dbReference type="OMA" id="RFNCYSE"/>
    <dbReference type="OrthoDB" id="7464992at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034982">
        <property type="term" value="P:mitochondrial protein processing"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd07331">
        <property type="entry name" value="M48C_Oma1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2010.10">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051156">
        <property type="entry name" value="Mito/Outer_Membr_Metalloprot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22726">
        <property type="entry name" value="METALLOENDOPEPTIDASE OMA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22726:SF1">
        <property type="entry name" value="METALLOENDOPEPTIDASE OMA1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="252"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M48" evidence="8">
        <location>
            <begin position="173"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBF85685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="376" mass="42339" checksum="C563AF3CDC634004" modified="2005-04-26" version="1">MFRFPITPSLRMTVRPPGPIAPRPCISKSTFRCSSRSALASSKRTQPPRSFISYSRPVPRAFPQAHARSFSSSSHRHFYNGGNRYRRFDGPGRQPLIVHLLQKARPIHFVMVGGVIGGVYVYNTDTVEMTGRRRFNCVSHQQELKMGEQSYREVLRDCQGRILPEYHPLTIMVNRVLHRLVPMAPIDGADWKVHVIKDDNMVNAFVLPGGKVFVFTGILPICKDEDGLAAVLGHEIAHVVAHHTGERMSNNFVTMGVIFLAALLFDISGNIPSLLLNLMYSLPNSRTQEAEADNIGLMMMSKACFNPEAAVDFWARMQRAEKQAPPQFISTHPSNYNRMEAIRGWLDKAQAEYENSGCMGTGSWMPGFRKASNDFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BC84</accession>
    <accession>C8VPQ9</accession>
    <name>Q5BC84_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_01846</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF85677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_659450.1">
        <property type="nucleotide sequence ID" value="XM_654358.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BC84"/>
    <dbReference type="GeneID" id="2874908"/>
    <dbReference type="KEGG" id="ani:ANIA_01846"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN1846"/>
    <dbReference type="eggNOG" id="ENOG502SIHY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043294_0_0_1"/>
    <dbReference type="InParanoid" id="Q5BC84"/>
    <dbReference type="OMA" id="GSWHVSW"/>
    <dbReference type="OrthoDB" id="5344482at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="319"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="339"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF85677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="360" mass="38501" checksum="978B7E06AAB96A2C" modified="2005-04-26" version="1">MAQSLPTPFTPDCDFTSLDTPRGGSGSLSITALARFEFEAGKGNDGTKILMVEWEDDDWSRSSCPPGGSWNVEWEGKKAVLPADEKTSSNTRRLYFLIPPHATIPPVITLTYNPPASADSSQEPKPIQLNPLPAIFPPELGADGRSAGKKGVLHTIWAKKRVQVLEKEIREESLNNVEGIAFHMALQEKEWIEANFGLGPDSQKNSIQSQDPNYPMGPATPVSPSVGGKLGEKLRGLKLQTSQRELSAAEGSHLLSPQSPDVAVSSFNSFHSIQPSTTRSNPTSNPPSGSVKTVAHYPPESLQAQQNVGFGGGFASMGAIAPSVSSGSDSGEDLFAKALSPRSPDLPRSPFSFSPETLHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BC89</accession>
    <accession>C8VPQ4</accession>
    <name>Q5BC89_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NmrA-like family protein, putative (AFU_orthologue AFUA_4G02840)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_01841</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF85668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_659445.1">
        <property type="nucleotide sequence ID" value="XM_654353.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BC89"/>
    <dbReference type="GeneID" id="2874906"/>
    <dbReference type="KEGG" id="ani:ANIA_01841"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN1841"/>
    <dbReference type="eggNOG" id="ENOG502S5T1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_10_4_1"/>
    <dbReference type="InParanoid" id="Q5BC89"/>
    <dbReference type="OMA" id="APVQQDH"/>
    <dbReference type="OrthoDB" id="419598at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="CDD" id="cd05269">
        <property type="entry name" value="TMR_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052718">
        <property type="entry name" value="NmrA-type_oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47129:SF1">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47129">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="1">
        <location>
            <begin position="5"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF85668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="306" mass="34728" checksum="936E73333A2D154E" modified="2005-04-26" version="1">MTLKYLITGATGGLGKQVLNYFVDHVPASEFAAASSRASNRARFEDRGIAFRHVDYDDEESLDSGLRDVENLLFVSSNTFDNERRDKQHRRLIDAAKRVGVKHVWYTSLAFGGFSDDSRAAVQQAHLITERILKESGLTYTSIREGVYAEAFPVFINWYPDSTTVTLPADGEIAYTRRAELGEATARIMLQGSYENQIVLFTAEETITSKEIVDIINETTKRQVKLEIVSPQEYIRINSANDQGGKPKAFFEMVLTWWEDIAKGELRTTHPLMREILGRPPTKPQDALRALLTENPDYTWHQNYAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="104" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BCB1</accession>
    <accession>C8VPM9</accession>
    <name>Q5BCB1_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ANIA_01819</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF85622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_659423.1">
        <property type="nucleotide sequence ID" value="XM_654331.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BCB1"/>
    <dbReference type="STRING" id="227321.Q5BCB1"/>
    <dbReference type="GeneID" id="2874674"/>
    <dbReference type="KEGG" id="ani:ANIA_01819"/>
    <dbReference type="eggNOG" id="ENOG502SKH5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_8_4_1"/>
    <dbReference type="InParanoid" id="Q5BCB1"/>
    <dbReference type="OMA" id="VEPFVRM"/>
    <dbReference type="OrthoDB" id="419598at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05251">
        <property type="entry name" value="NmrA_like_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF30">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="5">
        <location>
            <begin position="5"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="313"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBF85622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="343" mass="37952" checksum="86022B2017B90187" modified="2005-04-26" version="1">MSSPTIFVCGATGTQGSAIISSIQKHQPTTKIHGITRDPSSEQSKALQAGGVMLFEGNFNDEDSLRTAMTGCTALFLNLMPNLTEIAQELAQANRILQIAKEVGVHQVVYSSGLVTNAERRKYWDPTSFVAKIVLSKKQVEEAVRIAGFKYYTIIRPGNFMTNFLAPYVYRQYPGLAERGEFTTAFTRDTVIPMIDPNDIGEFGAAAFMEPERFHGKEIAIASELLTLDEILASLSKAAGRQLKANYMSQEEIDKQVKTNPFVGGQLMARDMVDEVDIEYMTTFGVQTVHSSELQTTSSISDTYTPHHFIRTVAKDSSQAPIRDKQEQSITTDALPAKDMKEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BCG8</accession>
    <accession>C8VP64</accession>
    <name>Q5BCG8_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ragulator complex protein LAMTOR1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">ANIA_01762</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Late endosome membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Lysosome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the LAMTOR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF85514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_659366.1">
        <property type="nucleotide sequence ID" value="XM_654274.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BCG8"/>
    <dbReference type="STRING" id="227321.Q5BCG8"/>
    <dbReference type="GeneID" id="2874725"/>
    <dbReference type="KEGG" id="ani:ANIA_01762"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN1762"/>
    <dbReference type="eggNOG" id="ENOG502SGDI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1409230_0_0_1"/>
    <dbReference type="InParanoid" id="Q5BCG8"/>
    <dbReference type="OMA" id="GYGALNH"/>
    <dbReference type="OrthoDB" id="5299893at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045121">
        <property type="term" value="C:membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071986">
        <property type="term" value="C:Ragulator complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071230">
        <property type="term" value="P:cellular response to amino acid stimulus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043410">
        <property type="term" value="P:positive regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032008">
        <property type="term" value="P:positive regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001919">
        <property type="term" value="P:regulation of receptor recycling"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028209">
        <property type="entry name" value="LAMTOR1/MEH1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13401">
        <property type="entry name" value="RAGULATOR COMPLEX PROTEIN LAMTOR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13401:SF2">
        <property type="entry name" value="RAGULATOR COMPLEX PROTEIN LAMTOR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15454">
        <property type="entry name" value="LAMTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01262">
        <property type="entry name" value="LAMTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="9" id="KW-0458">Lysosome</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0519">Myristate</keyword>
    <keyword evidence="8" id="KW-0564">Palmitate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="108"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CBF85514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="164" mass="17718" checksum="595A75E983298DBA" modified="2005-04-26" version="1">MGVCSSCLGGGRRDSTDPESSRLLEDDIYQPGYSYGALNHNQQANQPDPGYVRREREALEAICQRTSDSVIDIWSLQPQPHLQPQATLHNSVSSSSSKAHEPSIIVTTIDPDAPADSTSLKRGAVPKHWGEVVINPRKGKRSRPGSSSAVESGDKDVFGVLKVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="111" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BD85</accession>
    <accession>C8VMM5</accession>
    <name>Q5BD85_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Small nuclear ribonucleoprotein G</fullName>
            <shortName evidence="10">snRNP-G</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">ANIA_01495</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Plays a role in pre-mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the heptameric LSM1-LSM7 complex, which consists of LSM1, LSM2, LSM3, LSM4, LSM5, LSM6 and LSM7. Component of the heptameric LSM2-LSM8 complex, which consists of LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8. The LSm subunits form a seven-membered ring structure with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF84982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_659099.1">
        <property type="nucleotide sequence ID" value="XM_654007.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BD85"/>
    <dbReference type="FunCoup" id="Q5BD85">
        <property type="interactions" value="778"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5BD85"/>
    <dbReference type="GeneID" id="2874980"/>
    <dbReference type="KEGG" id="ani:ANIA_01495"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN1495"/>
    <dbReference type="eggNOG" id="KOG1780">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076902_10_0_1"/>
    <dbReference type="InParanoid" id="Q5BD85"/>
    <dbReference type="OMA" id="MSKAQPP"/>
    <dbReference type="OrthoDB" id="2146at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034719">
        <property type="term" value="C:SMN-Sm protein complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097526">
        <property type="term" value="C:spliceosomal tri-snRNP complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005687">
        <property type="term" value="C:U4 snRNP"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036261">
        <property type="term" value="P:7-methylguanosine cap hypermethylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01719">
        <property type="entry name" value="Sm_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000019">
        <property type="entry name" value="Small nuclear ribonucleoprotein G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044641">
        <property type="entry name" value="Lsm7/SmG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034098">
        <property type="entry name" value="Sm_G"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10553">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10553:SF2">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10 12" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 10" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="11">
        <location>
            <begin position="3"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CBF84982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="78" mass="8856" checksum="EAA8ED84AAFC9C8F" modified="2005-04-26" version="1">MPQAQPELKKYMEKRVFCELNGNRKVIGVLRGYDVFMNIVLDEAFEEKPGGEKVAIGMIVIRGNSVVMLEALERISEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="109" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BDJ3</accession>
    <accession>C8VRT8</accession>
    <name>Q5BDJ3_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Meiotic recombination protein Ski8/Rec14, putative (AFU_orthologue AFUA_1G08860)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ANIA_01387</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF87597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_658991.1">
        <property type="nucleotide sequence ID" value="XM_653899.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BDJ3"/>
    <dbReference type="STRING" id="227321.Q5BDJ3"/>
    <dbReference type="GeneID" id="2877164"/>
    <dbReference type="KEGG" id="ani:ANIA_01387"/>
    <dbReference type="eggNOG" id="KOG4155">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_57_11_1"/>
    <dbReference type="InParanoid" id="Q5BDJ3"/>
    <dbReference type="OMA" id="LDSSMCL"/>
    <dbReference type="OrthoDB" id="10251741at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055442">
        <property type="entry name" value="Beta-prop_EML-like_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051510">
        <property type="entry name" value="SKI8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44090:SF1">
        <property type="entry name" value="SUPERKILLER COMPLEX PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44090">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23414">
        <property type="entry name" value="Beta-prop_EML_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="EML-like second beta-propeller" evidence="4">
        <location>
            <begin position="104"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="104"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="182"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="224"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBF87597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="306" mass="32764" checksum="AACED40285E099BE" modified="2005-04-26" version="1">MNSKQYLSYGSADNTHPTDIFALAVTEKQILSASGSNALQVHSTTNPDFPLVQTLEAHKAGCHHVVTDAKGSRAVSVGFGGEVVIWESHEGTWSKTKDVVLADIWAVALSADGQYLAGTTQDGHVKVWDMNANEEEIRDHETKGSFGTCIDLSPDGRFIASGHENGSVYIFSTETGRMPFSLSGLVKPVRSVAFSPGGKFLAAAGDSRVIVLYDTTSGEQVASLTGHAAWILSLSWSNTGEYLLSGSFDGKVKVWSIDTRNCVATHSETERAIWSVIWLPKIGKSEGFATAGANRSISFYREATGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BEI8</accession>
    <accession>C8VTW8</accession>
    <name>Q5BEI8_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ANIA_01042</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF88274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_658646.1">
        <property type="nucleotide sequence ID" value="XM_653554.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BEI8"/>
    <dbReference type="GeneID" id="2876810"/>
    <dbReference type="KEGG" id="ani:ANIA_01042"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN1042"/>
    <dbReference type="HOGENOM" id="CLU_1532094_0_0_1"/>
    <dbReference type="InParanoid" id="Q5BEI8"/>
    <dbReference type="OMA" id="EYIIRHI"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF88274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="195" mass="22540" checksum="18EBCD226E9B6642" modified="2005-04-26" version="1">MEETYLDLPIFHALFDSIKNDPEPQRSVSMKGLGTALLAGYFPIINGWIITQSRIQAAGSVVLRVQHYLRMGRDGQRPARIADHLLACVVHDTQDWSNAMEELDGLSAERWNVENGYCWVVVFHGLDVYFFCYRQNRPFGERYAGCGTRFFENGEEFIQNKYHLQRDTALIHEIMAFMASRTYILYAKNSFNTEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="126" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BFA5</accession>
    <accession>C8VQV6</accession>
    <name>Q5BFA5_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Hydroxyisocaproate dehydrogenase, putative (AFU_orthologue AFUA_1G14400)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ANIA_00775</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF88808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_658379.1">
        <property type="nucleotide sequence ID" value="XM_653287.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BFA5"/>
    <dbReference type="FunCoup" id="Q5BFA5">
        <property type="interactions" value="452"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5BFA5"/>
    <dbReference type="GeneID" id="2876552"/>
    <dbReference type="KEGG" id="ani:ANIA_00775"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN0775"/>
    <dbReference type="eggNOG" id="KOG0069">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019796_1_2_1"/>
    <dbReference type="InParanoid" id="Q5BFA5"/>
    <dbReference type="OMA" id="HHTRAAM"/>
    <dbReference type="OrthoDB" id="9991913at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030267">
        <property type="term" value="F:glyoxylate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016618">
        <property type="term" value="F:hydroxypyruvate reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12168">
        <property type="entry name" value="Mand_dh_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000282">
        <property type="entry name" value="Glyoxylate reductase protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050223">
        <property type="entry name" value="D-isomer_2-hydroxyacid_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996">
        <property type="entry name" value="2-HYDROXYACID DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996:SF257">
        <property type="entry name" value="GLYOXYLATE REDUCTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="5">
        <location>
            <begin position="52"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="6">
        <location>
            <begin position="119"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBF88808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="327" mass="35893" checksum="B406BF22CD5060B6" modified="2005-04-26" version="1">MPSALLIGDITHARKEWEDLSSILTLKEFPSGNREDFIRNLKDGKYDDLVAIYRSNTSTKFTGPFDAELISLLPKSLKYICHNGAGYDNIDIPACSEKGISVSSTPVAVNNATADVGIFLMIGALRQAYVPLTAIREGKWHGQTTLGHDPKGKVLGILGMGGIGREMANRARAFGMTIQYHNRSRLSPELEQGAKYVSFDDLLATSDVLSLNLALNPSTRHIIGEKEFQKMKDGVVIVNTARGALIDEKALVAALESKKVMSAGLDVYENEPIVELGLLNNPRVMLLPHIGTMTYETQKEMEILVLDNLRSAVEKGELITQVPEQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="110" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BFV6</accession>
    <accession>C8VSD5</accession>
    <name>Q5BFV6_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">3-oxoacyl-(Acyl-carrier-protein) reductase (AFU_orthologue AFUA_6G11210)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ANIA_00574</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF89205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_658178.1">
        <property type="nucleotide sequence ID" value="XM_653086.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BFV6"/>
    <dbReference type="STRING" id="227321.Q5BFV6"/>
    <dbReference type="GeneID" id="2876349"/>
    <dbReference type="KEGG" id="ani:ANIA_00574"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_0_1"/>
    <dbReference type="InParanoid" id="Q5BFV6"/>
    <dbReference type="OMA" id="SIAQTCA"/>
    <dbReference type="OrthoDB" id="4131217at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180">
        <property type="entry name" value="3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE (AFU_ORTHOLOGUE AFUA_6G11210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180:SF66">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBF89205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="287" mass="30444" checksum="6E05EFE9DA8FFBE1" modified="2005-04-26" version="1">MLTHRTATQLGQRSDQPRYLASYMHAGMVERQTNRDVSHQFARNGAKAIYICDFTSTHLPTHAREIKSLYPSVDVHTRTFDAADEAALKAVIDEAIQNYGRLDIFFANAGISGSNVPFTEVTGEQFAETLRINTVGVFLAAKHASLAMRKTSPEKKYPGGSIIATASVAGLRSNAGATDYSASKAAVVSIAQTVAFQLAGTGIRINAICPGVVETGMTAAMYEAARARGTERKIGQLNPLQRGAVADEIARVALFLGSDESSYVNGQAWAVCGGLSAGHPVVPGKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BG64</accession>
    <accession>C8VT63</accession>
    <name>Q5BG64_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Integral membrane protein, putative (AFU_orthologue AFUA_1G04315)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_00466</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF89430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_658070.1">
        <property type="nucleotide sequence ID" value="XM_652978.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BG64"/>
    <dbReference type="GeneID" id="2876243"/>
    <dbReference type="KEGG" id="ani:ANIA_00466"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN0466"/>
    <dbReference type="eggNOG" id="ENOG502RZUI">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_081019_0_0_1"/>
    <dbReference type="InParanoid" id="Q5BG64"/>
    <dbReference type="OMA" id="VECFFFD"/>
    <dbReference type="OrthoDB" id="5553410at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
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    <dbReference type="Gene3D" id="3.20.180.10">
        <property type="entry name" value="PNP-oxidase-like"/>
        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR019595">
        <property type="entry name" value="DUF2470"/>
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    <dbReference type="InterPro" id="IPR037119">
        <property type="entry name" value="Haem_oxidase_HugZ-like_sf"/>
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    <dbReference type="PANTHER" id="PTHR37783">
        <property type="entry name" value="MEMBRANE PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G04315)-RELATED"/>
        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR37783:SF1">
        <property type="entry name" value="MEMBRANE PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G04315)-RELATED"/>
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    <dbReference type="Pfam" id="PF10615">
        <property type="entry name" value="DUF2470"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2470" evidence="2">
        <location>
            <begin position="9"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF89430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="222" mass="25099" checksum="041EB8503FA234DA" modified="2005-04-26" version="1">MADDTSRKTFIINHMNTDHARSLSLYLRAYCGLSARASTSPKLEDVRLTDMVISAQGSRYTIPFDPPLASLSETRARVVAMHKEALKRLNLSDIKITRYSPPKGSQWIGFTLCLAILVGYCRRGNFEPGSLVYEGLGLAKYPGFTGFSYKWQPWIWGPLAVAHGFEALVLLGYMRLRKYGVQAFSGLWWTWMVLGFVEGFPAWMRFDGLVRRAEAEEKEKSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BGQ4</accession>
    <accession>C8VUC8</accession>
    <name>Q5BGQ4_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Cytochrome b561 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">ANIA_00276</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="20">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF89831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_657880.1">
        <property type="nucleotide sequence ID" value="XM_652788.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BGQ4"/>
    <dbReference type="STRING" id="227321.Q5BGQ4"/>
    <dbReference type="GeneID" id="2876056"/>
    <dbReference type="KEGG" id="ani:ANIA_00276"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN0276"/>
    <dbReference type="eggNOG" id="ENOG502S2JA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007077_1_0_1"/>
    <dbReference type="InParanoid" id="Q5BGQ4"/>
    <dbReference type="OMA" id="IFQVLWG"/>
    <dbReference type="OrthoDB" id="19261at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000444">
        <property type="term" value="C:MIS12/MIND type complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd08760">
        <property type="entry name" value="Cyt_b561_FRRS1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006593">
        <property type="entry name" value="Cyt_b561/ferric_Rdtase_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007128">
        <property type="entry name" value="PMF1/Nnf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15459:SF2">
        <property type="entry name" value="CYTOCHROME B561 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15459">
        <property type="entry name" value="POLYAMINE-MODULATED FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00665">
        <property type="entry name" value="B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50939">
        <property type="entry name" value="CYTOCHROME_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="14" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-0132">Cell division</keyword>
    <keyword evidence="15" id="KW-0137">Centromere</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="9" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="12 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0498">Mitosis</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="66"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="102"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="256"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b561" evidence="18">
        <location>
            <begin position="33"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="276"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="329"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="452"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="507"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="291"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="329"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="346"/>
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    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="365"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="473"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="547"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="586"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="613"/>
            <end position="622"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="635"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="660"/>
            <end position="673"/>
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    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="674"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="714"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="747"/>
            <end position="762"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CBF89831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="762" mass="84416" checksum="5EF37C91AB574184" modified="2005-04-26" version="1">MSDNSGLTSPGEASYSSNTLHVGDGTWDSDRDTFLLPNLMGVNFETMRYNGMGNRFRDMPHYHTLIVAHGVIATIVFLGLVPLSILLVRYYSLRNPYQAFRYHVWCQVLTLFLSTVVFVLGWFAVGPNRSLTNPHHGIGLAIYVIVIFQVFWGWLVHKIERNKKRFHVPLKLVLHRWMGRALAILGIVQIPLGLTLYGSPKVLFILYAVAAFILLATFFVLSYKYDSDGGSSGDGDYDSRYSYISRRPDDDHRRSSLGRMAAAGAAGAGLATLFRRRSRDRGSESSQTSYMDEKYSDEASRHGGWGRKLLKLGALGGGAILAKRLFDRRRERESDTESGRYQPAHRRTDSMTEESLSRLDDRPPPRPSYPAPINRPPNRPPSREQSINSSYYDYSYFSRDEERPSHTARNALFGAGALAAIKGFFSGRKRKDDEQRHVEEMRRHDLANEKIARANSKRRYTGDGYYPQRKRPASQTATDISTDLTPRPARAQYPPESALSAAPVAPGVVGDAHSQQPPAPPIHYDPPSAMMPAEPTTSQPPPPIAPVAPAHGGSAGPSSGHLPIPGGSGWQRDGHVESPPVSIKVKMHDDGRNITLRRLTEEEAAAGREARRRERRNSRRRNGSVSSLSGNEGTGSRDRWRRVEELERQQQEQMDRERAAAAAAAAATANTTPAPVPQTPLAPGPAASGHSIPPPASSFLPPHQSMSYIPPRAPSTNPYGSITSPGTYTGTDASEYATNRRRRRAERARARQERQGHSVDFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BGX4</accession>
    <accession>C8VUV5</accession>
    <name>Q5BGX4_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Acyltransferase, putative (AFU_orthologue AFUA_5G11030)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ANIA_00206</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GPAT/DAPAT family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF89976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_657810.1">
        <property type="nucleotide sequence ID" value="XM_652718.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BGX4"/>
    <dbReference type="STRING" id="227321.Q5BGX4"/>
    <dbReference type="GeneID" id="2875983"/>
    <dbReference type="KEGG" id="ani:ANIA_00206"/>
    <dbReference type="eggNOG" id="KOG3730">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015023_0_0_1"/>
    <dbReference type="InParanoid" id="Q5BGX4"/>
    <dbReference type="OMA" id="ENMICKM"/>
    <dbReference type="OrthoDB" id="10255570at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07993">
        <property type="entry name" value="LPLAT_DHAPAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022284">
        <property type="entry name" value="GPAT/DHAPAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045520">
        <property type="entry name" value="GPAT/DHAPAT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041728">
        <property type="entry name" value="GPAT/DHAPAT_LPLAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12563:SF17">
        <property type="entry name" value="DIHYDROXYACETONE PHOSPHATE ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12563">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19277">
        <property type="entry name" value="GPAT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="7">
        <location>
            <begin position="210"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="103"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBF89976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="806" mass="90843" checksum="C2594F91F0EEF646" modified="2005-04-26" version="1">MSPAKSSVGESAPDLEIVGDQVTIHPSGYTGGPEPQDGGITERNLINNMARFRENPFDFLREVSSYMMSGTGWRAYDDIIGQPIYYSGFTEQIKSHILASPILREKVKELAEARLEVEDKEGLLQIRTGEFARTHTQRRKELESNLNEVVDQMLDNMICKMESKRFIRGAYYLASQLLTRAYHQGIHVSSEEILRLRAVAEEAAKKKQSIVFLPCHKSHVDYVSLQIICYRLGIALPVVVAGDNLNIPFVGAFLQHAGAMWIRRSFGNDPLYNTVVQAYIDTILQKGYNFECFIEGGRSRTGKLLSPKFGILSFIVDSVLSGRTEDTIICPVSTQYDKVIETESYISELLGQPKRKENLADFLSSSSVLSLKLGRVDVRFHKPWSLREYISQHLSRLPQPLQLKKGLKLSYSDRGRLLRSLGYRVLSDINNVSVMMPTALVGTVLLTLRGRGVGKAELVRRVEWLCDRVRAKGGRVAHFYRYPTEVVVNRALDVLGPKIVGEVTGLVEPTYFAVDRFQLSFYRNMTIHLFISEALVSAAMYTRVKQGGGPAHQRISYGDLLHHVTFLSQLFRGEFIFPPEGLTTNLENTLRTLEKDQVLAITRDSTGAPQFIELSETERQCGRENYDFYCFLIWPFIEASWLGTVSLLGLTPPLNGPKDVWINLSKAQNNAQLGDLSYFEAVNKEALKNSYDRFAEEGIIIVAKSKENRSSTKMRLAPEWTPERDPDTGKLLPQGRLWDFMELIAKSRREGKNRRDGATVSSRVLTMSDNVGRTLFESAESRAPATDVDVDVSTRAPRRKALTSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>C8V0Z6</accession>
    <name>C8V0Z6_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FHF complex subunit HOOK-interacting protein C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ANIA_10801</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FHIP family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF69659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_663947.2">
        <property type="nucleotide sequence ID" value="XM_658855.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V0Z6"/>
    <dbReference type="GeneID" id="2871243"/>
    <dbReference type="KEGG" id="ani:ANIA_10801"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN10801"/>
    <dbReference type="eggNOG" id="KOG3695">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004692_1_0_1"/>
    <dbReference type="InParanoid" id="C8V0Z6"/>
    <dbReference type="OMA" id="DHAQEFH"/>
    <dbReference type="OrthoDB" id="5350595at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019384">
        <property type="entry name" value="FHIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045669">
        <property type="entry name" value="FHIP_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21705:SF11">
        <property type="entry name" value="FHIP FAMILY PROTEIN CG3558"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21705">
        <property type="entry name" value="RAI16 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19314">
        <property type="entry name" value="DUF5917"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10257">
        <property type="entry name" value="RAI16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHF complex subunit HOOK-interacting protein C-terminal" evidence="3">
        <location>
            <begin position="536"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="661"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="12"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="735"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="759"/>
            <end position="773"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBF69659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="843" mass="93285" checksum="FC1B576A095653F9" modified="2009-11-03" version="1">MDFWSRIIGGSRSLSKSPRATSPTERLTTFKRTCNTLQQIWRSSNSTAAEQAAIVHARHCIERLNSVLSDESRGPAPHPCLAYAASSQIFVTVTKLALSSYDEAMLRSATVLFNTLIDSEVDGVVDNRLFARALVDLVRRADKKSADIEGRLVELLFGVANNIRLQPNILPAWFAPRTDDEEQSTGSVEFAGTMRTDDFPLFYLLVEWVHHAGRAGDFARTGLLYLIETASRSKDLERWLIESDLATLMATGLGALYSQLGSLGSCLDVEPVVPHVISHSDHAQQETALPPALGSSMDSFMAYLLFWQDTIDHCKSAEVVATLLDHFQVLFLEQLLYPSLLESSDVEGGSTAAVLTYLYRILASVDQEDLVQRILHFLLASPSGVDVQAPEKKKDMSASRRKSLDVLAAFSQEAARPSPTLFNLRDLVLLGLQSPNRQTVLATLRLLTVILQRYSSFSIFLIRTNPTQPAKQRTVGALNAEVGHLLTMATSIMEEPTLDQSFDNYLKDASWILESRLATPPPDNCSETLPCEIRQEDPIVRELLGCLETFFTNTVIVNLALTEVLMSIASSHLMALDGWLLVDPAKYHYVQSDGGSSNDKSEDILDQVHRMYQEPTWSPADTPALTAALRRLVDKVQEWRKQVEDFDILIAARRDLLHEDDVRTNQAEQNLGTPAPRSTERYSSNTPRTPPLGFDQGTPRGRRDLRNLTSPQRSIVGSPLREVTVNKTHSPPPRDASEARSAAEELRKRLAAPFLPESKVSTFNDRTDNSAQEPSPADQEVAVTDEEERKPKAETASLGHVLTNVVILYEFLLEISAAVQARGAIFEEAGFHGVGSSLPVDDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>C8V141</accession>
    <name>C8V141_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">U4/U6.U5 small nuclear ribonucleoprotein 27kDa protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ANIA_10835</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May play a role in mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of a tri-snRNP complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SNUT3 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF71081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_664209.2">
        <property type="nucleotide sequence ID" value="XM_659117.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V141"/>
    <dbReference type="STRING" id="227321.C8V141"/>
    <dbReference type="GeneID" id="2870522"/>
    <dbReference type="KEGG" id="ani:ANIA_10835"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN10835"/>
    <dbReference type="eggNOG" id="KOG3263">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075596_0_1_1"/>
    <dbReference type="InParanoid" id="C8V141"/>
    <dbReference type="OMA" id="VDSSTMW"/>
    <dbReference type="OrthoDB" id="21368at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013957">
        <property type="entry name" value="SNRNP27"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31077">
        <property type="entry name" value="U4/U6.U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 27 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31077:SF1">
        <property type="entry name" value="U4_U6.U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 27 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08648">
        <property type="entry name" value="SNRNP27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="U4/U6.U5 small nuclear ribonucleoprotein 27kDa protein" evidence="9">
        <location>
            <begin position="189"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="222"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="33"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="65"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="75"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBF71081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="243" mass="29254" checksum="DFEB7B5F76436CF8" modified="2009-11-03" version="1">MAEPPAKRARRIDSSAMWDMDDRGSRSPVVDSNYDRNSRRDPSDDGREGPREDRKYRSRSEDRRDKRRERSRSRDRRDRDRDRGRDRRERDKDGRDARVRDRSGSRDRYTDRRGYSFKGDRYRDRSRSPTRNGTRDRASPGRGSRGDRRNERRDQRDRHNIAPDSKYRADWTKDEMDMDLDEAEEDDIDELMRRCLGFSKFRSTKNTKVPGNNAYGVRKEKKTEYRQYMNRQGGFNRPLSPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C8V287</accession>
    <name>C8V287_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">D-lactate dehydratase</fullName>
            <ecNumber evidence="1">4.2.1.130</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ANIA_06796</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>methylglyoxal + H2O = (R)-lactate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27754"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
            <dbReference type="ChEBI" id="CHEBI:17158"/>
            <dbReference type="EC" id="4.2.1.130"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase C56 family. HSP31-like subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.130" evidence="1"/>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF71478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467172.1">
        <property type="nucleotide sequence ID" value="XM_050611117.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V287"/>
    <dbReference type="FunCoup" id="C8V287">
        <property type="interactions" value="64"/>
    </dbReference>
    <dbReference type="STRING" id="227321.C8V287"/>
    <dbReference type="GeneID" id="2870335"/>
    <dbReference type="KEGG" id="ani:ANIA_06796"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN6796"/>
    <dbReference type="eggNOG" id="ENOG502S0R6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070319_2_0_1"/>
    <dbReference type="InParanoid" id="C8V287"/>
    <dbReference type="OMA" id="GEKTGFW"/>
    <dbReference type="OrthoDB" id="543156at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019172">
        <property type="term" value="F:glyoxalase III activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019243">
        <property type="term" value="P:methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd03141">
        <property type="entry name" value="GATase1_Hsp31_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050325">
        <property type="entry name" value="Prot/Nucl_acid_deglycase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48094:SF11">
        <property type="entry name" value="GLUTATHIONE-INDEPENDENT GLYOXALASE HSP31-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48094">
        <property type="entry name" value="PROTEIN/NUCLEIC ACID DEGLYCASE DJ-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="DJ-1/PfpI" evidence="6">
        <location>
            <begin position="81"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBF71478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="237" mass="25530" checksum="E08D19CEE6726661" modified="2009-11-03" version="1">MAPKVLVVLTSFDKIEANNHPTGWYLPEFAHPWEVLHSKTELTIASPKGGAAPLDPSSVKMFENDPVSARFLKEQESLWKNTLKLEEVLPRAEKGEFDAIFYVGGHGPMFDLVTDKTSIALIQSFAKAKKPVSAVCHGPCVFVNVTTPSGKPLVADAEVTGFSNVEEDQVDLSKVMPFMLEDELNKKSGGKYVKADQPWGEKVVVSQVKELGGPLITGQNPASATGVGKALLEALGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>C8V3K8</accession>
    <name>C8V3K8_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Probable enoyl-CoA hydratase, mitochondrial</fullName>
            <ecNumber evidence="2">4.2.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ANIA_05916</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.17" evidence="2"/>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF70577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467054.1">
        <property type="nucleotide sequence ID" value="XM_050612506.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V3K8"/>
    <dbReference type="STRING" id="227321.C8V3K8"/>
    <dbReference type="GeneID" id="2870992"/>
    <dbReference type="KEGG" id="ani:ANIA_05916"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN5916"/>
    <dbReference type="eggNOG" id="KOG1680">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009834_7_6_1"/>
    <dbReference type="InParanoid" id="C8V3K8"/>
    <dbReference type="OMA" id="FCDARED"/>
    <dbReference type="OrthoDB" id="2018133at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0000247"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0000247"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006550">
        <property type="term" value="P:L-isoleucine catabolic process"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006574">
        <property type="term" value="P:L-valine catabolic process"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019626">
        <property type="term" value="P:short-chain fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000019">
        <property type="entry name" value="Enoyl-CoA hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.12.10:FF:000001">
        <property type="entry name" value="Probable enoyl-CoA hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941:SF54">
        <property type="entry name" value="ENOYL-COA HYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941">
        <property type="entry name" value="ENOYL-COA HYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00073937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBF70577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="289" mass="30864" checksum="B99C1E7B6657DBFB" modified="2009-11-03" version="1">MFARQSTRFLFPRTTTVITRVRLYSSAAPSYEHILTSTPKPGVGLITLNRPKALNALSSPLFKEVNDALSKYDESKDIGAIIITGSEKAFAAGADIKEMAPLTFASAYSNNFIAPWSHLANSIRKPVIAAVSGFALGGGCELALMCDIIYCTASATFGQPEIKLGVIPGAGGSQRLTAAVGKSKAMELILTGKNFSGKEAGEWGVAAKVVDGGKEELLEEAVKTAETIAGYSRVATVAAKEVVNKSQDLGVREGVEYERRLFHGLFGSQDQKIGMTAFAEKKKPQWSHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>C8V3T3</accession>
    <name>C8V3T3_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ANIA_10458</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF75638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467496.1">
        <property type="nucleotide sequence ID" value="XM_050611468.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V3T3"/>
    <dbReference type="GeneID" id="74896414"/>
    <dbReference type="KEGG" id="ani:ANIA_10458"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN10458"/>
    <dbReference type="HOGENOM" id="CLU_2073124_0_0_1"/>
    <dbReference type="InParanoid" id="C8V3T3"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF75638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="118" mass="12626" checksum="EE0FD06827746B1F" modified="2009-11-03" version="1">MGDDYLSNGTVSHHHTPDCKRRSLYVGLVSSGALSGRLDEMLSTLDVITHSDTSGGVNSLALCESKKDMGVRCHRVDLVEGPFGCWLAVAAVMGCFRPRVAWPRNNRGLVSIHGSAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2025-10-08" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>C8V3Z5</accession>
    <name>C8V3Z5_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GTP-binding protein ypt1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ANIA_04281</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Preautophagosomal structure membrane</location>
            <topology evidence="8">Lipid-anchor</topology>
            <orientation evidence="8">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF74330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_661885.2">
        <property type="nucleotide sequence ID" value="XM_656793.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V3Z5"/>
    <dbReference type="SMR" id="C8V3Z5"/>
    <dbReference type="FunCoup" id="C8V3Z5">
        <property type="interactions" value="1080"/>
    </dbReference>
    <dbReference type="STRING" id="227321.C8V3Z5"/>
    <dbReference type="GeneID" id="2873700"/>
    <dbReference type="KEGG" id="ani:ANIA_04281"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN4281"/>
    <dbReference type="eggNOG" id="KOG0084">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041217_23_1_1"/>
    <dbReference type="InParanoid" id="C8V3Z5"/>
    <dbReference type="OMA" id="TQMAKDF"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031985">
        <property type="term" value="C:Golgi cisterna"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031521">
        <property type="term" value="C:spitzenkorper"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd01869">
        <property type="entry name" value="Rab1_Ypt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000069">
        <property type="entry name" value="Ras GTP-binding protein YPT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057289">
        <property type="entry name" value="Rab1/Ypt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0636">Prenylation</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="188"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00060489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00074496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CBF74330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="201" mass="22303" checksum="8DC1A5B0BEBDF378" modified="2009-11-03" version="1">MNPEYDYLFKLLLIGDSGVGKSCLLLRFADDTYTESYISTIGVDFKIRTIELDGKTVKLQIWDTAGQERFRTITSSYYRGAHGICVVYDVTDMDSFNNVKQWLQEIDRYATEGVNKLLVGNKSDMEDKKVVEYTVAKEFADSLGIPFLETSAKNASNVEQAFLTMARQIKERMGTATVNNKPTVQVGQGQGVQSGSAGGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C8V7C4</accession>
    <name>C8V7C4_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">awh11</name>
        <name evidence="2" type="ORF">ANIA_03725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF75524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_661329.2">
        <property type="nucleotide sequence ID" value="XM_656237.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V7C4"/>
    <dbReference type="FunCoup" id="C8V7C4">
        <property type="interactions" value="95"/>
    </dbReference>
    <dbReference type="STRING" id="227321.C8V7C4"/>
    <dbReference type="GeneID" id="2873145"/>
    <dbReference type="KEGG" id="ani:ANIA_03725"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN3725"/>
    <dbReference type="eggNOG" id="ENOG502SDMM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_102617_2_0_1"/>
    <dbReference type="InParanoid" id="C8V7C4"/>
    <dbReference type="OMA" id="RSHDNHA"/>
    <dbReference type="OrthoDB" id="2348401at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007250">
        <property type="entry name" value="HSP9_HSP12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04119">
        <property type="entry name" value="HSP9_HSP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002590">
        <property type="entry name" value="HSP9/HSP12_fun"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF75524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="89" mass="9797" checksum="7B15FCC30EE1FD44" modified="2009-11-03" version="1">MSDFARKDFSTKAKEEITPDASKSTQERVKETVTDTTDRISRGVQPDDQKSTTQQAFDKSQRVSDREGHGSTPQSIGDKVKNAVGLGDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2025-10-08" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>C8V7M5</accession>
    <name>C8V7M5_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NGG1 interacting factor Nif3, putative (AFU_orthologue AFUA_6G12480)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ANIA_10437</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GTP cyclohydrolase I type 2/NIF3 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF75613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_661289.2">
        <property type="nucleotide sequence ID" value="XM_656197.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V7M5"/>
    <dbReference type="FunCoup" id="C8V7M5">
        <property type="interactions" value="640"/>
    </dbReference>
    <dbReference type="STRING" id="227321.C8V7M5"/>
    <dbReference type="GeneID" id="2873107"/>
    <dbReference type="KEGG" id="ani:ANIA_10437"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN10437"/>
    <dbReference type="eggNOG" id="KOG4131">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037423_0_1_1"/>
    <dbReference type="InParanoid" id="C8V7M5"/>
    <dbReference type="OMA" id="NFDKTHL"/>
    <dbReference type="OrthoDB" id="3345469at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1390.30:FF:000001">
        <property type="entry name" value="GTP cyclohydrolase 1 type 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1390.30:FF:000008">
        <property type="entry name" value="NGG1 interacting factor Nif3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1390.30">
        <property type="entry name" value="NIF3 (NGG1p interacting factor 3)-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002678">
        <property type="entry name" value="DUF34/NIF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036069">
        <property type="entry name" value="DUF34/NIF3_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00486">
        <property type="entry name" value="YbgI_SA1388"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13799">
        <property type="entry name" value="NGG1 INTERACTING FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13799:SF13">
        <property type="entry name" value="NIF3-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01784">
        <property type="entry name" value="DUF34_NIF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102705">
        <property type="entry name" value="NIF3 (NGG1p interacting factor 3)-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="149"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR602678-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBF75613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="370" mass="39452" checksum="7275E3852FEAD3B1" modified="2009-11-03" version="1">MNRIPARLFSAMSAFLAPSSSPFTRAVVNSMRKLYPESLADKSFDNTGLLLEAPFNPTRRQKNSVLLTIDLTKAVADEAIARKDSVVVAYHPIIFRGLKSLTFNDPQQQSLLRLAAEGISVYSPHTAVDATPGGMGDWLCDVVTGATTPSSSSSVADLESPPSALYSAPTYPKPGPVSPSTSSKIIPHTRSTIHPSPAPVPSGLEDAGMGRLVTFAEPQPLASVIDNIASGVGYPGGIPIAIPQSASVEDIKIRTVGVCPGSGSSVLMKGVKQIPDLLFTGEMSHHETLFAIENGSVVVALAHSNTERGYLRAVMKDKLEGVLKGEWAELRTEEGKGEEAGLNEVYEDETCEVHVSEKDRDPYGIMVRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>C8VB42</accession>
    <name>C8VB42_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Zn(II)2Cys6 transcription factor (Eurofung)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ANIA_07061</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF79166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467917.1">
        <property type="nucleotide sequence ID" value="XM_050611948.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VB42"/>
    <dbReference type="STRING" id="227321.C8VB42"/>
    <dbReference type="GeneID" id="2869937"/>
    <dbReference type="KEGG" id="ani:ANIA_07061"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN7061"/>
    <dbReference type="eggNOG" id="ENOG502SJ25">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022493_0_0_1"/>
    <dbReference type="InParanoid" id="C8VB42"/>
    <dbReference type="OMA" id="PMSCDRC"/>
    <dbReference type="OrthoDB" id="3266505at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0000318"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
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    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF3">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="29"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="109"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="661"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="109"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBF79166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="753" mass="83355" checksum="1B85AF2C03CFC873" modified="2009-11-03" version="1">MDPIGTFNPQKRPGDNPADQQRRKRARQSCETCKARKTKCVGLENGTCQYCTQLGLLCQVNLKARKRPFYRISEAAYESSIALLRRFVSEEELPELTVEGIQGVLSKLDDPANDKERIDANPHSHSHSQSPTELSAAAAALGSSPRSQAGANEGRSSVAAIEEQPESVGAEAEAEEGVMEPDEHPALQEERGCMVLDSLGKYRYVGADSSIRWNHAARMAQHATSNTDPKVIAPLKTGLLPPRTPESLTGSARGAGVYLPPAAMAMRYAGFFFQEVHCLYWFYSLEQFYGALEETLEDHGAKASASWLCSLYSIFAIGSMAPDNQIARAGKDAEGDDKRAADYLALAKDLVPEVSEEADTESVKAFGLLSLGMHAMCYSVGAYLHLGTAVRIGFSLGLHRNISPRKSSSVERERARRLWWTIYTLDHEMAIRFGYPCAVGDESGLVKTPPASEQVMDPGPNMPLGYQSLCVSLVRIRKKIGQSCFVVPAQAGGRLPIRQVFESLNALRTWFDEIPQYFSREASQPPQHRRAVSILHLRYWSSVIFVTRPFLLYTVSRPAAIKEPAKARCYEEISRKCIEAAEQSVDIFKRMVKEQTLSSRILFDCHCIGEAMWILILAVQKLGLEKHRQMLQLCLETVRGMEQFGWCEKVAPELEARVHESGIMQPQSRREMQHTQQSGHRSLDFHSQANGAEANAGGGILPESRADSLEDTTLNFDISEFGLLETFDMDMDNGSGLMDMLADATLSASQLGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>C8VCY5</accession>
    <name>C8VCY5_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_07227</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF78811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467870.1">
        <property type="nucleotide sequence ID" value="XM_050611897.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VCY5"/>
    <dbReference type="GeneID" id="2870072"/>
    <dbReference type="KEGG" id="ani:ANIA_07227"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN7227"/>
    <dbReference type="eggNOG" id="ENOG502QZ63">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049199_0_0_1"/>
    <dbReference type="InParanoid" id="C8VCY5"/>
    <dbReference type="OMA" id="AIYTCFM"/>
    <dbReference type="OrthoDB" id="445007at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31630:SF7">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31630">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF78811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="431" mass="48529" checksum="A897D76ED64F11AB" modified="2009-11-03" version="1">MPRAPSSTFPSPNVSYTILLAFGWSEIKAPISVLSLDCSSTIIRLLQARSAIAATGSLLVILVITPTFDQLRPLGAFPPPPPPPSSSTFRMSTATVTESVTITKDNVRMRLDGRDPKFGDFRDDLARDGFAVVKGAIPRERALKYADEMHSWLEGFNLGYDRNDPSTVHKDRLPLINEKGMCMHYSVAHEKFVWDVRSEPGVVEAFEKVYNNKDLIVSFDAVNFGFPNRTDLPPNKPWPHQDQDPDKPDFRCLQGLVNLLPNGPNDGGLIVCRGAHLLSDEFHSDPVIRAEERIPAWTPEWYGFTETGMKWLADHNCEWVKVCAEPGDILLWDSRTPHYNLSPKGQTPRFCIYTCYMPVADASQEDLVRKKESFENRLGTTHWPNANHTGSNVATRDGKECPYNRFKPVMEPVLNERAFRLTGIPYLRSQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>C8VEC4</accession>
    <name>C8VEC4_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_11610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF80508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468087.1">
        <property type="nucleotide sequence ID" value="XM_050612135.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VEC4"/>
    <dbReference type="GeneID" id="74897171"/>
    <dbReference type="KEGG" id="ani:ANIA_11610"/>
    <dbReference type="HOGENOM" id="CLU_2740012_0_0_1"/>
    <dbReference type="InParanoid" id="C8VEC4"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF80508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="71" mass="7686" checksum="B3D90D55D9589B60" modified="2009-11-03" version="1">MLRVTAGGNKLLWKPPFPPIFSSAISGAMEYANLQELGWATLTSDDANAESKAADAEEKQAPQLIWPDDLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>C8VG88</accession>
    <name>C8VG88_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Mitochondrial carrier protein, putative (AFU_orthologue AFUA_6G12900)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">ANIA_10686</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF81738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468251.1">
        <property type="nucleotide sequence ID" value="XM_050612312.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VG88"/>
    <dbReference type="GeneID" id="74896543"/>
    <dbReference type="KEGG" id="ani:ANIA_10686"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN10686"/>
    <dbReference type="eggNOG" id="KOG0762">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_16_1_1"/>
    <dbReference type="InParanoid" id="C8VG88"/>
    <dbReference type="OMA" id="WVTATPF"/>
    <dbReference type="OrthoDB" id="193856at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000184">
        <property type="entry name" value="Mitochondrial carrier protein, putative (AFU_orthologue AFUA_6G12900)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF10">
        <property type="entry name" value="SLC (SOLUTE CARRIER) HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="95"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="190"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CBF81738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="303" mass="33248" checksum="F6D87CD338925F6F" modified="2009-11-03" version="1">MSADFWAGYISGAIGIIIGNPLDLIKVRLQASSSANGPVSPRQLTRFESTSSLVRGAAAPILGYGALNALLFVSYNRALMLLDRSVTDPTNPQNCALYKLWLAGALGGIASWTVSSPTEFIKCRAQLDACPGVSSWTVAKDIVRTRGWRGLYFAGGITCARDSIGYGFYFWSYEYCKRLMSSPDGEDTSNTALKVLFCGGIAGIVTWASVFPLDVIKTRLQASTIADYAEARPLLQAQTSKQTLGSFDLAREMYRAEGFKAFYRGIGVCSLRAFIVNAAQWATYEWLMRCFQDPTWYKSLETI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>C8VHK4</accession>
    <name>C8VHK4_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AMP-binding enzyme, putative (AFU_orthologue AFUA_7G01530)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_03417</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF82751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_661021.2">
        <property type="nucleotide sequence ID" value="XM_655929.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VHK4"/>
    <dbReference type="STRING" id="227321.C8VHK4"/>
    <dbReference type="GeneID" id="2874126"/>
    <dbReference type="KEGG" id="ani:ANIA_03417"/>
    <dbReference type="eggNOG" id="KOG1176">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_59_11_1"/>
    <dbReference type="InParanoid" id="C8VHK4"/>
    <dbReference type="OMA" id="KGKWFKT"/>
    <dbReference type="OrthoDB" id="2962993at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031956">
        <property type="term" value="F:medium-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201:SF28">
        <property type="entry name" value="ENZYME, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G01530)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="1">
        <location>
            <begin position="56"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="2">
        <location>
            <begin position="541"/>
            <end position="619"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF82751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="634" mass="69007" checksum="799470E6E6E7A06E" modified="2009-11-03" version="1">MHQRTLISASRGLISRRASAASFNCTSCPTFFGFAVRRSLATLPNLPLFRALKNHDPARLAVVHNPSFRSFTYGNLVADVVKAQDQLWNSSGRGRDGLRGERIAFLAENSYDYVVILLSILASDAIAVPLSTGFPIHELKYIMNNSQAGMLVATERYADMAEKIMEGELDRQPILDMRGKIRTGSSDVGAVELEGLDGNSGGMMLYTSGTTNRPVRLLADLADGVVIPQSALASQAASLLEAWKYSPGDRLLHLLPLHHIHGTVNAIITPVLSGSSIEFMFPFNPTAVWNRLAEPFLPEGTKDKITFLNAVPTIYNRLLSTFPTLSPQVQSASKVAISPEHLRLNISGSAALPTPTKKAWQDLSNGNVLLERYGMTEVGMALSCGLDFTDRVDGSVGWPLPSVEVRLVDTDTNKVIQPGEEIDGSGRAREGEIQLRGPTIFREYWGNEKATQETFAPDADGKGPWFKTGDVATRRSVETAGLGKSGEWAKGPMYFIQGRRSVDIIKVGGEKVSALEVERELLSLYVHQVLPSSLQELIEVTRPQIAEAAVVGLPSEQWGQKVVAIVVLNSEVAARTGRNGKSWGVLDMRWALKDRLAAYKLPSEMKVLEGAIPRNAMGKGTVLLLTSFTSLVPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>C8VHZ7</accession>
    <name>C8VHZ7_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">GABA transporter, putative (Eurofung)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ANIA_03304</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF82995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468412.1">
        <property type="nucleotide sequence ID" value="XM_050612497.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VHZ7"/>
    <dbReference type="GeneID" id="2874482"/>
    <dbReference type="KEGG" id="ani:ANIA_03304"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN3304"/>
    <dbReference type="eggNOG" id="KOG1289">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004495_6_1_1"/>
    <dbReference type="InParanoid" id="C8VHZ7"/>
    <dbReference type="OMA" id="RWQGTLF"/>
    <dbReference type="OrthoDB" id="3257095at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015185">
        <property type="term" value="F:gamma-aminobutyric acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015812">
        <property type="term" value="P:gamma-aminobutyric acid transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF4">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="209"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="247"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="289"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="349"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="375"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="420"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="450"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBF82995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="517" mass="56700" checksum="08A1B54ECB28CEC2" modified="2009-11-03" version="1">MEVHTKPPRLGTMDVEVHSPAGSHEGGRQAGTVLDDTDMHRMGKVQELKGTDIRRTVPLGLRVRIAAIPEIPQLPYRYLASAIFFPNYAVPVPTDHAAQPGWMSVLAWQAGSASGSFLTGTIIQGLITIRNPDYSPESWHGTLFVFAMIFVIYVFNVYASDAMPVLNNLLMIFHVLSWCVILIVLWAMAPHRTAKSVFTEWSTQGGWNSIGLSVMIGQISAIYGSLSSDATAHMSEEVSNAGRNVPLAIAWGYFTNGIMAIVLLIAYLFSIPSVEDALSDETGFPFLYVFRNAVSTAGVNGLTSIILIPVIFSNIFFNASTSRQTFAFARDRGLPFADWIAHVDKRRKIPVNAIFLSCLISCLLSLINIGSETAFNAIISLNVAALMYSYIISISCVIYRKLKCPETLPARRWDMGSWGLPVNIIGLVYSCFALFWSLWPGQKHVTAETFNWSVVIFGGVFVISLVLGTDATASIQWSFTNNRQSEPFQPAGNGKTQPITSGYGGVFRKSPMNCAPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>C8VJW5</accession>
    <name>C8VJW5_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Sister chromatid cohesion acetyltransferase Eco1, putative (AFU_orthologue AFUA_3G06000)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">ANIA_10336</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetyltransferase family. ECO subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF84074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468551.1">
        <property type="nucleotide sequence ID" value="XM_050612655.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VJW5"/>
    <dbReference type="FunCoup" id="C8VJW5">
        <property type="interactions" value="29"/>
    </dbReference>
    <dbReference type="STRING" id="227321.C8VJW5"/>
    <dbReference type="GeneID" id="74896346"/>
    <dbReference type="KEGG" id="ani:ANIA_10336"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN10336"/>
    <dbReference type="eggNOG" id="KOG3014">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039183_2_2_1"/>
    <dbReference type="InParanoid" id="C8VJW5"/>
    <dbReference type="OMA" id="WHVYEES"/>
    <dbReference type="OrthoDB" id="428854at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061733">
        <property type="term" value="F:protein-lysine-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028005">
        <property type="entry name" value="AcTrfase_ESCO_Znf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028009">
        <property type="entry name" value="ESCO_Acetyltransf_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45884">
        <property type="entry name" value="N-ACETYLTRANSFERASE ECO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45884:SF2">
        <property type="entry name" value="N-ACETYLTRANSFERASE ECO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13880">
        <property type="entry name" value="Acetyltransf_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13878">
        <property type="entry name" value="zf-C2H2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="N-acetyltransferase ESCO zinc-finger" evidence="11">
        <location>
            <begin position="156"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase ESCO acetyl-transferase" evidence="12">
        <location>
            <begin position="329"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="27"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="88"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="123"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF13880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CBF84074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="401" mass="44489" checksum="9C8BB619AB17574A" modified="2009-11-03" version="1">MPWTVTNSFKRGLMMKTYGRSSWRVYDDDQRPAAKKRRVLSDCESDAAEKSLEYAIRESTANVRSSPSRRNSLALSDGSQDTDLSTPPSSPPPRLSPPPQNTRKPTFSFLKRKSAPKDGANGSPLSEVNSNSVRASLDPPKKKAGTPVSQQPALKQMQLDLGHEVRKTCATCGMEYVPSNSEDASLHKKFHDMNSTGVDLGKAFMRANASRWVYEATRFEEGYVVIVDRKSSPTAKNQAKKVLEVISKELSSPVIEDDTLWSQTEPPKHLRKNGASEKVDRYKVFLHMKDSRCVGACLTERIWESHAVDKASIQTDGADSAVTVRDDTHPAIVGISRIWTSGSSRRKGIAMDLLDCVVSNFIYGMEIPKEQVAFSQPTNSGKSLAQAFFGPENEWHVYKES</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>C8VK32</accession>
    <name>C8VK32_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ANIA_11172</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF82418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468324.1">
        <property type="nucleotide sequence ID" value="XM_050612398.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VK32"/>
    <dbReference type="SMR" id="C8VK32"/>
    <dbReference type="GeneID" id="74896824"/>
    <dbReference type="KEGG" id="ani:ANIA_11172"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN11172"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_1_1"/>
    <dbReference type="InParanoid" id="C8VK32"/>
    <dbReference type="OMA" id="SWKDEIM"/>
    <dbReference type="OrthoDB" id="5325318at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05352">
        <property type="entry name" value="MDH-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF4">
        <property type="entry name" value="CHAIN DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G08710)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBF82418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="254" mass="27410" checksum="89A006290F930164" modified="2009-11-03" version="1">MSKFSLKGRTALVTGGGRGCGLAFARGLAEAGADVAVFDIIDPRPEFHAIEKDYNVRTAYYKVDVSSQDSLKDGFAQFQQDFDGKLDICVPCAGINRHTCFLGFTYEEHHDLLSINVLGLYFTAQYAAKQMIANGTHHGSIILVASMASYVAVRDQNCSAYCGTKGAVRAMCPAIAKELTEYGIRVNSISPGYVNTEMTAAFSHLVEGWKAETINKRIAEPEDIMGACVFLASDASSYMTGQDIVVDGGVTRIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>C8VK50</accession>
    <name>C8VK50_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">UTP--glucose-1-phosphate uridylyltransferase</fullName>
            <ecNumber evidence="3 7">2.7.7.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ANIA_09148</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="journal article" date="2023" name="MBio" volume="14" first="e0041423" last="e0041423">
            <title>CryoEM analysis of the essential native UDP-glucose pyrophosphorylase from &lt;i&gt;Aspergillus nidulans&lt;/i&gt; reveals key conformations for activity regulation and function.</title>
            <authorList>
                <person name="Han X."/>
                <person name="D'Angelo C."/>
                <person name="Otamendi A."/>
                <person name="Cifuente J.O."/>
                <person name="de Astigarraga E."/>
                <person name="Ochoa-Lizarralde B."/>
                <person name="Grininger M."/>
                <person name="Routier F.H."/>
                <person name="Guerin M.E."/>
                <person name="Fuehring J."/>
                <person name="Etxebeste O."/>
                <person name="Connell S.R."/>
            </authorList>
            <dbReference type="PubMed" id="37409813"/>
            <dbReference type="DOI" id="10.1128/mbio.00414-23"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (3.98 ANGSTROMS)</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Plays a central role as a glucosyl donor in cellular metabolic pathways.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>alpha-D-glucose 1-phosphate + UTP + H(+) = UDP-alpha-D-glucose + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19889"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.7.7.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the UDPGP type 1 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.9" evidence="3 7"/>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF82451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468333.1">
        <property type="nucleotide sequence ID" value="XM_050612407.1"/>
    </dbReference>
    <dbReference type="PDB" id="8C0B">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.98 A"/>
        <property type="chains" value="A/B/C/D/E/F/G/H=1-514"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VK50"/>
    <dbReference type="EMDB" id="EMD-16357"/>
    <dbReference type="SMR" id="C8VK50"/>
    <dbReference type="FunCoup" id="C8VK50">
        <property type="interactions" value="888"/>
    </dbReference>
    <dbReference type="STRING" id="227321.C8VK50"/>
    <dbReference type="GeneID" id="2867998"/>
    <dbReference type="KEGG" id="ani:ANIA_09148"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN9148"/>
    <dbReference type="eggNOG" id="KOG2638">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023632_3_0_1"/>
    <dbReference type="InParanoid" id="C8VK50"/>
    <dbReference type="OMA" id="KEYCFLS"/>
    <dbReference type="OrthoDB" id="932129at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003983">
        <property type="term" value="F:UTP:glucose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006078">
        <property type="term" value="P:(1-&gt;6)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005977">
        <property type="term" value="P:glycogen metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006011">
        <property type="term" value="P:UDP-alpha-D-glucose metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00897">
        <property type="entry name" value="UGPase_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.10.10:FF:000001">
        <property type="entry name" value="UTP--glucose-1-phosphate uridylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000002">
        <property type="entry name" value="UTP--glucose-1-phosphate uridylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002618">
        <property type="entry name" value="UDPGP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016267">
        <property type="entry name" value="UDPGP_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43511">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01704">
        <property type="entry name" value="UDPGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000806">
        <property type="entry name" value="UDPGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="13" id="KW-0002">3D-structure</keyword>
    <keyword evidence="5 7" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="403"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000806-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000806-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CBF82451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="13">
        <source>
            <dbReference type="PDB" id="8C0B"/>
        </source>
    </evidence>
    <sequence length="514" mass="57558" checksum="45A977F3DD86D1B6" modified="2009-11-03" version="1">MATKDLPTHLSSNTGFGKHHGKTQSHMAFENASTSVAASQMRNALNALAETVPDPNERKRFEAEMDNFFALFRRFLNDKAKGNVVNWDRIAPPQPSQVVNYDDIGKESSVEFLNKLAVVKLNGGLGTSMGCVGPKSVIEVREGMSFLDLSVRQIEHLNRTYNVNVPFVLMNSFNTDQDTQSIIKKYQGHNVDIITFNQSRYPRIIKDSLLPAPKSFDAPLQDWYPPGHGDVFESLYNSGTLDKLLERGVEYIFLSNADNLGAVVDTRILQHMIDTKAEYIMELTDKTKADVKGGTIIDYEGKVRLLEIAQVPKEHVNEFKSIKKFKYFNTNNIWMNLRAIKRVVEENELEMEIIANEKSIPADKKGEADQAIYQLETAVGAAIRHFKNAHGVNVPRRRFLPVKTCSDLLLVKSDLYRLEHGQLVMDPNRFGGVPVIKLGSDFKKVSDFQKRIPSIPRIVELDHLTITGAVNLGRNVTLKGTVIIVATEGSTIDIPPGSVLENCVVQGSLRILEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>C8VL75</accession>
    <name>C8VL75_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ANIA_11638</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF84529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VL75"/>
    <dbReference type="HOGENOM" id="CLU_3428520_0_0_1"/>
    <dbReference type="InParanoid" id="C8VL75"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF84529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="20" mass="2278" checksum="24618D1EB58D391A" modified="2009-11-03" version="1">MYILQNTVEGAQGTWPSLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>C8VLF1</accession>
    <name>C8VLF1_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ANIA_02023</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the putative lipase ROG1 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF86030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468792.1">
        <property type="nucleotide sequence ID" value="XM_050612941.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VLF1"/>
    <dbReference type="STRING" id="227321.C8VLF1"/>
    <dbReference type="GeneID" id="2875017"/>
    <dbReference type="KEGG" id="ani:ANIA_02023"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN2023"/>
    <dbReference type="eggNOG" id="ENOG502T0EP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_182_0_1"/>
    <dbReference type="InParanoid" id="C8VLF1"/>
    <dbReference type="OMA" id="AIREPAN"/>
    <dbReference type="OrthoDB" id="427518at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007751">
        <property type="entry name" value="DUF676_lipase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052374">
        <property type="entry name" value="SERAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031469">
        <property type="entry name" value="SesB_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182:SF2">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05057">
        <property type="entry name" value="DUF676"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17046">
        <property type="entry name" value="Ses_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF676" evidence="9">
        <location>
            <begin position="16"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal death-pathway protein SesB" evidence="10">
        <location>
            <begin position="267"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="269"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="269"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CBF86030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="304" mass="33383" checksum="6080A5A51CCC126B" modified="2009-11-03" version="1">MSIRAVREPANAKVDIVFVHGLHGDQAPWTSASDVFWPEKLLPGKISDACILSFEYEAAIGLFFDEDDEITDISSDLINELMDHRTEKEKEERPIIFVAHCLGGVVLENALVRAAEHPRKRELIGCIHGILLLGTPHFQPGSVAAATKYLQVAQAEIPSESDLKDRLYRLSGIPQRFAELKQAGAEFEVEGFYAGAGTKLGSTGKDVKIVDEALARGPDAPPPERLARNQLRLSQYDGEDDKDFKKVVRVLTQWASKIVLPEEDKGAANVSNATFSGSHNSGLQLGQNVAHHARVPPRKADYID</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>C8VLL8</accession>
    <name>C8VLL8_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">FAD binding domain protein (AFU_orthologue AFUA_4G10100)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ANIA_02042</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2 oxidized [cytochrome P450] + NADPH = 2 reduced [cytochrome P450] + NADP(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24040"/>
            <dbReference type="Rhea" id="RHEA-COMP:14627"/>
            <dbReference type="Rhea" id="RHEA-COMP:14628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:55376"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="EC" id="1.6.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF86066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468798.1">
        <property type="nucleotide sequence ID" value="XM_050612948.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VLL8"/>
    <dbReference type="STRING" id="227321.C8VLL8"/>
    <dbReference type="GeneID" id="2875069"/>
    <dbReference type="KEGG" id="ani:ANIA_02042"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN2042"/>
    <dbReference type="eggNOG" id="KOG1158">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_17_5_1"/>
    <dbReference type="InParanoid" id="C8VLL8"/>
    <dbReference type="OMA" id="LCCGGGC"/>
    <dbReference type="OrthoDB" id="1856718at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030586">
        <property type="term" value="F:[methionine synthase] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003958">
        <property type="term" value="F:NADPH-hemoprotein reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050667">
        <property type="term" value="P:homocysteine metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000027">
        <property type="entry name" value="FAD binding domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.990.10:FF:000007">
        <property type="entry name" value="Methionine synthase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF84">
        <property type="entry name" value="METHIONINE SYNTHASE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="8">
        <location>
            <begin position="223"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="51"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="89"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBF86066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="644" mass="70975" checksum="495347F07ADC8013" modified="2009-11-03" version="1">MVHAVLPQTPLSPRAAAARPTYTHRESGNVPMSSTSHPDNPVPEEPRVRSLSVTNKSFGGSSVSSQETENTDSESPSTPPTEQSDEEFAEKQPKDDAGRQRRASTVLISQGPDDMRRILENVGTGGTQKLQPMCCGGGCCRLQPLNRAPGPVSVINPVTPPDNKAYQSLKLNVDLLTLDSELTNIAPLPEKKVSFSAVPPSAVNMNLGPADHPPPFVQPHPPYNVYRAPVYHARELTSAGAEKRTYHFDIDVTDYPAESGMVDFVVGGAIGVCPMNKEEEVEDIFNQLGIPKSIRDKKVTVRTTHGRWPTIWGKEEARELITTRRELLKWCSDIQSYAPTKGLFRLLAEYASDPSEKKILLFLASAQGQGAFCDLRTSSHITVSQLLHAFPSSHPPLDHLLSTLNQLMPRFYSLSQDPLISRKRKGDQYRRLVEIAVTVAESEDWKGGSRTGVGSGFMERLARQAVEAQAQGREPGDLDLHVPMFRGLMANPLAKRFASDGPMLLIGAGVGIAPFRGFVQRRLQSANCANKVWVLQGVRDSLLDELYRGEWGVEEDKVRKVVQSRRGESKYVQEEVRNQADLVWFVINSLDGRVFVCGSGKGMGEGVEAALVDVAMAKGNLNREEAELFWENKKEAGQYIAETW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>C8VND6</accession>
    <name>C8VND6_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">LITAF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ANIA_02337</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CDIP1/LITAF family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF86634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468863.1">
        <property type="nucleotide sequence ID" value="XM_050613020.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VND6"/>
    <dbReference type="GeneID" id="2874997"/>
    <dbReference type="KEGG" id="ani:ANIA_02337"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN2337"/>
    <dbReference type="eggNOG" id="ENOG502S7BR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095549_1_2_1"/>
    <dbReference type="InParanoid" id="C8VND6"/>
    <dbReference type="OMA" id="YTYKRVC"/>
    <dbReference type="OrthoDB" id="5599753at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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    <dbReference type="InterPro" id="IPR006629">
        <property type="entry name" value="LITAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037519">
        <property type="entry name" value="LITAF_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23292:SF6">
        <property type="entry name" value="FI16602P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23292">
        <property type="entry name" value="LIPOPOLYSACCHARIDE-INDUCED TUMOR NECROSIS FACTOR-ALPHA FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10601">
        <property type="entry name" value="zf-LITAF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00714">
        <property type="entry name" value="LITAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51837">
        <property type="entry name" value="LITAF"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LITAF" evidence="7">
        <location>
            <begin position="80"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="16"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="53"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="72"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBF86634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="179" mass="19175" checksum="E16A619A56DE5025" modified="2009-11-03" version="1">MSEKANYEPNGQGPPSYGPPGPAQPAPVVPGTQPPYHPTEPNPEIQVQAIGYPAGQQQPQNAAPQMDPPQPYVQGQPQPSQYPTAFPLHALQRTPQVVDCPACHQREMTRTEAVNGNSTHAWAAVLCCCACVGCIPYFVAYFKNVDHHCGRCGQLLATFHGSGHVVVHPQGGQVQQAPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>C8VNV1</accession>
    <name>C8VNV1_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Autophagy-related protein Atg28 (Eurofung)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_01701</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF85396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_659305.2">
        <property type="nucleotide sequence ID" value="XM_654213.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VNV1"/>
    <dbReference type="STRING" id="227321.C8VNV1"/>
    <dbReference type="GeneID" id="2875543"/>
    <dbReference type="KEGG" id="ani:ANIA_01701"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN1701"/>
    <dbReference type="eggNOG" id="ENOG502SANW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015530_0_1_1"/>
    <dbReference type="InParanoid" id="C8VNV1"/>
    <dbReference type="OMA" id="HWNLLIC"/>
    <dbReference type="OrthoDB" id="5342758at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="59"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="385"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="98"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="68"/>
            <end position="89"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="398"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="427"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF85396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
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    </evidence>
    <sequence length="454" mass="50977" checksum="72C4533372B3E24B" modified="2009-11-03" version="1">MSAIFPQNMAHSLVPVPLRTTAHQDPLLHVERQAKHIQRNLQLLIDAQSEGLLAGLSDQQPDESALKSHATSSRSQLSSLSGASTASVLQPRKKKIGLHTARENILKSMQDLMQLREEEREILASRQEEINYGLTDIETFNTKKSKLEQAIAAINENMETQRTRELRAESTRLEQEIHELENKLAQMKTRHRHVVEELAQVENSVEAKLSSYKASLSLLESDVRRFLASPPVTPSARGTAGENFYSLKPNRRTLEMAQEHWRLEQSVLQHRQEEVNAEIEALEDGCDVWKRVVEVISGFEKRLRANMRRSIQDQGEPLQDKNVANNKGNLVQAIMEDLEQTTDLVEQNLGHAQSKDWKLLVCCISAEFEALHEARVMLLSIFDNTDDVNPPTAYGDPGKPRKSSDGDSHGDPLGVDNPEPPADLLQDMNSHSPGDANSETEDDEPDPAWLLPES</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>C8VR78</accession>
    <name>C8VR78_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Zn(II)2Cys6 transcription factor (Eurofung)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ANIA_09373</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF87493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468970.1">
        <property type="nucleotide sequence ID" value="XM_050613131.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VR78"/>
    <dbReference type="STRING" id="227321.C8VR78"/>
    <dbReference type="GeneID" id="2867935"/>
    <dbReference type="KEGG" id="ani:ANIA_09373"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN9373"/>
    <dbReference type="eggNOG" id="ENOG502SNQY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027371_1_1_1"/>
    <dbReference type="InParanoid" id="C8VR78"/>
    <dbReference type="OMA" id="QETHPAC"/>
    <dbReference type="OrthoDB" id="416217at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
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    <dbReference type="InterPro" id="IPR053157">
        <property type="entry name" value="Sterol_Uptake_Regulator"/>
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    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784">
        <property type="entry name" value="STEROL UPTAKE CONTROL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784:SF7">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="26"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBF87493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="448" mass="50991" checksum="001574D8D803D862" modified="2009-11-03" version="1">MLNVSPPEAQTQTNRLKRPHTKSRRGCYNCKNRRIKCSEAKPACGNCIFKELECVYPPPPRTEPYAVVQNHRTSTSVSLNAERSSSPSASLLSARIKATSFSGDDLRFWHHFLVDARPHLPFGDEGTWISTIPAFAHDCPPLLHSILSLGASHCALITSNSHGRQYHELAIAHRGKALKALSTTLSKGQSCTVLEMDGALATCYTLTFQAHHMADGVIDFAVMVRGCGLVTDWYFEQSRESMIFKLKSQGEMLEMITSWLPGEMQAVTEALTVRACMQSLEALRLHLDSPAHVSFYHTLKTAYEALLLSQRQAFIALAGIYMSWKEMSNSEFMAFVKPDNHISRALFMHYITIDTFMRPVYFELSHQRGIANTGGHFLIYRWAEEIYTALPREMKNLVRDLVSYIAFDLLPEVEKHKRQFPQWLHELQGFTEWLGRRLPLDMKEMYNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>C8VRX0</accession>
    <name>C8VRX0_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transmembrane glycoprotein, putative (AFU_orthologue AFUA_1G09270)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ANIA_01359</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF87650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_658963.2">
        <property type="nucleotide sequence ID" value="XM_653871.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VRX0"/>
    <dbReference type="FunCoup" id="C8VRX0">
        <property type="interactions" value="27"/>
    </dbReference>
    <dbReference type="STRING" id="227321.C8VRX0"/>
    <dbReference type="GeneID" id="2877138"/>
    <dbReference type="KEGG" id="ani:ANIA_01359"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN1359"/>
    <dbReference type="eggNOG" id="ENOG502QURR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_300361_0_0_1"/>
    <dbReference type="InParanoid" id="C8VRX0"/>
    <dbReference type="OMA" id="VHSRAKH"/>
    <dbReference type="OrthoDB" id="10264738at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043942">
        <property type="term" value="P:negative regulation of sexual sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070790">
        <property type="term" value="P:phialide development"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043935">
        <property type="term" value="P:sexual sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006644">
        <property type="entry name" value="Cadg"/>
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            <taxon>Eurotiomycetidae</taxon>
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        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
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                <person name="Selker E.U."/>
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                <person name="Penalva M.A."/>
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                <person name="Momany M."/>
                <person name="Tanaka T."/>
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                <person name="Asai K."/>
                <person name="Machida M."/>
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                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
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            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
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                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
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                <person name="Visser J."/>
                <person name="Oliver S.G."/>
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            <dbReference type="PubMed" id="19146970"/>
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        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="27" mass="3133" checksum="9E0DBA443D3A7859" modified="2009-11-03" version="1">MLGFKIIQKEPSKIEIILAIYNTEQLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>C8VSH0</accession>
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        </lineage>
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    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
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            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
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                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
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            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF87821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050469012.1">
        <property type="nucleotide sequence ID" value="XM_050613178.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VSH0"/>
    <dbReference type="GeneID" id="74896902"/>
    <dbReference type="KEGG" id="ani:ANIA_11297"/>
    <dbReference type="HOGENOM" id="CLU_2740014_0_0_1"/>
    <dbReference type="InParanoid" id="C8VSH0"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002993213" evidence="2">
        <location>
            <begin position="21"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF87821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="71" mass="7740" checksum="86E80E0C0B16B5B1" modified="2009-11-03" version="1">MQITVHLMFGVLHLFTSIQAGPYNACILRNGKDSKRTDGQKDLDSKNEANGKGEMDVDYSGETTSGLTMTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>C8VTT0</accession>
    <name>C8VTT0_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Extracellular SCP domain protein Pry1, putative (AFU_orthologue AFUA_1G02040)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ANIA_10057</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF89648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050469244.1">
        <property type="nucleotide sequence ID" value="XM_050610966.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VTT0"/>
    <dbReference type="STRING" id="227321.C8VTT0"/>
    <dbReference type="GeneID" id="74896177"/>
    <dbReference type="KEGG" id="ani:ANIA_10057"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN10057"/>
    <dbReference type="eggNOG" id="KOG3017">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_918372_0_0_1"/>
    <dbReference type="InParanoid" id="C8VTT0"/>
    <dbReference type="OMA" id="WRTINIV"/>
    <dbReference type="OrthoDB" id="337038at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd05384">
        <property type="entry name" value="CAP_PRY1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.33.10:FF:000031">
        <property type="entry name" value="Extracellular SCP domain-containing protein Pry1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018244">
        <property type="entry name" value="Allrgn_V5/Tpx1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00837">
        <property type="entry name" value="V5TPXLIKE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01009">
        <property type="entry name" value="CRISP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="3">
        <location>
            <begin position="102"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBF89648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="303" mass="33488" checksum="9D0C880001AE0E14" modified="2009-11-03" version="1">MREISFGQRKIHLIDPRLLPGGMHTSINRHQHRQPTHLQTILFSRVLKIIIYFLLLLLPNAISATETTVIVTVTESATATTTATTTTTPKVPQDPSYTSPRQFRSSILRTTNAYRAAHNASNLSWNETLADYAKDWAKGCKWKHSSGPYGENLAYGYKKASSAVTAWGDEAALYDFSKPTGFTEETGHFTQLVWKSTREVGCAAVDCGLTDLDDDEKERAQGWYVVCEYMPAGNVVGADDGLEYFRVNVQEGSEDSDSSSEDDSEHGDGGEGSDVSDFGNRASRGLVEWSKERVACPRRPPPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>C8VUT3</accession>
    <name>C8VUT3_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS multidrug transporter, putative (AFU_orthologue AFUA_1G15490)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ANIA_00890</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF88582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050469111.1">
        <property type="nucleotide sequence ID" value="XM_050613283.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VUT3"/>
    <dbReference type="FunCoup" id="C8VUT3">
        <property type="interactions" value="71"/>
    </dbReference>
    <dbReference type="GeneID" id="2876663"/>
    <dbReference type="KEGG" id="ani:ANIA_00890"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN0890"/>
    <dbReference type="eggNOG" id="KOG2615">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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        <property type="component" value="Chromosome VIII"/>
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        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="entry name" value="MFS_trans_sf"/>
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        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
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        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="65"/>
            <end position="87"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="124"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="199"/>
            <end position="223"/>
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    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="318"/>
            <end position="337"/>
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    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="373"/>
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    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="404"/>
            <end position="423"/>
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    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="435"/>
            <end position="458"/>
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    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="503"/>
            <end position="521"/>
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    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
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            <begin position="27"/>
            <end position="527"/>
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    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="530"/>
            <end position="558"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="530"/>
            <end position="542"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
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    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBF88582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="591" mass="65238" checksum="A72AA25107EC7F90" modified="2009-11-03" version="1">MFKRPAFLQSRRHEERSGDWSAFPIRQLFVLALCRICEPIAFMSIFPYVYHMVESFHVTSNDRKIALYAGLITSSFTFAEFSAGMFWGRMSDKIGRKPVLIMGLVGTAISMVVFGFAPNLATAMIARALGGLLNGNIGVLQTTVAEIVTVKEHQPRAYSIMPFVWCLGSIIGPAMGGALSQPCDNYPWLFSGESIFKKFPFLLPNLVCVVVLMTGIVVGLLFLEETHPEKKYRRDRGLELGNWLIGRCWGSRVQAVEEQDVKADSADAGYFDDYDEVPPPAYRSTETSPRLGPVREVDDLAVDDDIEKQMSGGKPKAFTKQVIFNIVGYGILAYHSVSFDQLMPVFLSTPKSKEDAVLPFKFTGGLGLSTKTIGLMLAVQGVYSMIAQLWLFPFVVRHFGTLRTFRFVLLVWPPLYLLVPYLILLPEKLQMTAAYVALICKITFHVIAFPSTAILLANAAPSSKVLGSINGAAASTASLSRAFGPSVTGFLHSKGLDSGYSVISWWACGIVCLIGAIQSFWMEESEPQRFMDEKKPEPDTSHTRNVLRGSFAADREDGTADEVRRLLSSARTSVDELEVPSIAADLRPVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-12-14" modified="2025-10-08" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>G5EAT8</accession>
    <accession>C8V629</accession>
    <name>G5EAT8_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ANIA_03946</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
            <location evidence="1">Centromere</location>
            <location evidence="1">Kinetochore</location>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="CBF75034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_656458.2"/>
    </dbReference>
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        <property type="interactions" value="455"/>
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    <dbReference type="KEGG" id="ani:ANIA_03946"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN3946"/>
    <dbReference type="eggNOG" id="KOG1166">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002115_1_0_1"/>
    <dbReference type="InParanoid" id="G5EAT8"/>
    <dbReference type="OMA" id="NCEKGVG"/>
    <dbReference type="OrthoDB" id="248495at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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    <dbReference type="GO" id="GO:0051754">
        <property type="term" value="P:meiotic sister chromatid cohesion, centromeric"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="AspGD"/>
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        <property type="entry name" value="STKc_Bub1_BubR1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Checkpoint protein kinase (SldA), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.430:FF:000003">
        <property type="entry name" value="Checkpoint serine/threonine-protein kinase BUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Bub1/Mad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013212">
        <property type="entry name" value="Mad3/Bub1_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012572">
        <property type="entry name" value="Mad3/Bub1_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14030:SF4">
        <property type="entry name" value="BUB1 KINASE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14030">
        <property type="entry name" value="MITOTIC CHECKPOINT SERINE/THREONINE-PROTEIN KINASE BUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08311">
        <property type="entry name" value="Mad3_BUB1_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08171">
        <property type="entry name" value="Mad3_BUB1_II"/>
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    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00777">
        <property type="entry name" value="Mad3_BUB1_I"/>
        <property type="match status" value="1"/>
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    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51489">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0137">Centromere</keyword>
    <keyword evidence="2" id="KW-0158">Chromosome</keyword>
    <keyword evidence="3" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BUB1 N-terminal" evidence="7">
        <location>
            <begin position="64"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="839"/>
            <end position="1173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="235"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="328"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="523"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="547"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="599"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="735"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="865"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="243"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="289"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="617"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="736"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="871"/>
            <end position="885"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBF75034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="1216" mass="136748" checksum="90052D60863AC962" modified="2011-12-14" version="1">MAATGDLIDFDIIENQKENIQSLPGGRSARELARIFSPRDPSDKLSSPSPNDTRTLNDAIRQEYEAELQAIGESDDPLDIYDRYVKWALNAYPTAQATPESGLLPLLERAVKSFLSSPHYKNDPRYLKLWLHYIRLFSDSPRETFAFMARHHVGEGLALFYEEFAAWLESVGRWTQADEVYRLGIDREARPTERLIRKYGEFQRRYEQQPQDNGPSSPALPAVRPALAAKVDPFASSAAAPTDPQSQQQGSRTTNAPKTKSGKPKMAIFTDTEPAANQPALGAQTKGWDSLESRHDRRKENQIEAKPWAGETLKAGRKAPPKEKLAVFRDESKSDLPTKEEMQSNPVPEHRIREAVNPRTGRRERVFVDLDAVYPDYKNPSIEVSFEELRAMKRGWMDRDWRKKGPLKQISGNAVQTEPNPFNDKALRDQFQQKLSLRNTDDHALNQPIVSEKTHDAKAAKGRKLKVREVKGETQTIKMKFDSPTGGKIRRKSTAEPTMTIHTRAATDEIYSIFNQPLKAETENVAESSDFDDDDYTSAGESTVGRISAASSDFGDDTFHKSFDEGDGDDFENTSADSVVNGEWTRFSAAELGAEATSFHSEAADPTQSTIHHAESDDTEDQDAGPEFEQPQRPRFIPEMPEDYVPPVGPYRDPVVVAQSRLPFMTPIVERTEHSFPSMTAARSNLYSAKTPSNVLNPTTTPRMPRMGNLLSSPLPTETPFHGQTMHGLEDIIESPTANRSGSSSLRVPSPTKDSNPQGTIIKDTLCNPIDRSIRDTILQELHTTLAAYPGYHAHPDTQSHYAPEIERFMKSSSKRSRSGGEAAFDVPIIDPPGGERSYIIRRELGAGAYAPVYLAESIDNLDSDSEMESVGSNSGRSTVSNSLTRQKTPRYSFEAIKLEVGPPNAWEFYMIQTAHHRLSQLPTLSRAADSIVRAHEMHIFKNESILVEDYRPQGTLLDLVNLVRNEGISGPATGEGGLDESLAMFFTIELFRTIQALHTCGILHGDIKADNCLIRFDDKPDPTQQILDENTDPREFYYSPSGAFGWKNKGLALIDFGRGIDMRAFDPSVQFVADWKTGEHECPEIREMRPWTHQIDLYGLAGTVHVMLFGKYIESVPTDASKKTYRIREPLKRYWEKDIWADVFDLLLNPSAERWARMEQKSNVNASNLPVLVSMQHLRERMESWLVDHAEKKGLGLQIRKLEAIFAEKKKRLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-12-14" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>G5EB16</accession>
    <accession>C8V1C4</accession>
    <name>G5EB16_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA (cytosine-5-)-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ANIA_06638</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.37" evidence="1"/>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF71150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_664242.1">
        <property type="nucleotide sequence ID" value="XM_659150.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G5EB16"/>
    <dbReference type="STRING" id="227321.G5EB16"/>
    <dbReference type="GeneID" id="2870392"/>
    <dbReference type="KEGG" id="ani:ANIA_06638"/>
    <dbReference type="eggNOG" id="ENOG502SB19">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012943_3_0_1"/>
    <dbReference type="InParanoid" id="G5EB16"/>
    <dbReference type="OMA" id="KPRVHTM"/>
    <dbReference type="OrthoDB" id="414133at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003886">
        <property type="term" value="F:DNA (cytosine-5-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044027">
        <property type="term" value="P:negative regulation of gene expression via chromosomal CpG island methylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.120.10">
        <property type="entry name" value="DNA Methylase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050390">
        <property type="entry name" value="C5-Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001525">
        <property type="entry name" value="C5_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031303">
        <property type="entry name" value="C5_meth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10629">
        <property type="entry name" value="CYTOSINE-SPECIFIC METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10629:SF52">
        <property type="entry name" value="DNA (CYTOSINE-5)-METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00145">
        <property type="entry name" value="DNA_methylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00105">
        <property type="entry name" value="C5METTRFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00095">
        <property type="entry name" value="C5_MTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51679">
        <property type="entry name" value="SAM_MT_C5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBF71150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="615" mass="69029" checksum="467C5D667C518BCB" modified="2011-12-14" version="1">MRQSAYIYLTFVSSCTVCELLLYTFLTRLSLPSCSRDMHNFYRPSVIVDDASDASSVTIDHDPDRLYFLREDSDTATREFIDLTEDETTHDGEYITDECFEVLREDWLASACASSPLSPELPEGQLLEEVCDADGIVYKPGNSVELHDGAFFRICSIRQALKGNIILTGRRLLKFKDHPDKYLPQWRNELIWVADETAEIPLWFVRRFVSVHFSNVCPIGQDCQKNNNPDGLFCRLKRVIQKETTSIEYLTFEEADAGFRAPSASLRHGWRGETAPFGSKEEAETPVIVLDDDNDFQDTILKQKAQRKYTFGDGFCGAGGVSCGAEAAGLDIKWAFDLCPHAAATYRLNFPNVECEGSDIFSFMTSNEEFMRVDISHGSPPCQTFSPAHTIPGPNDDANSAAIFSCWDLIRKAKPRVHTMEETSGLFDRHQQVFLRVICDFIETGYSVRWALLNCMWYGVPQSRKRLIIIASGPGESLPRLPRPTHGLPGSGLRDLTTISQAIRDIPTGSPDHDVVAARGRGVHNRRAPFDGNRQARTITCGGGDNYHPSGLRGFTLREFACLQTFPLGFRFLGGRTQVKRQIGNAVPPLLAKAVFKEIIRSLQDTDERELHENQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-12-14" modified="2025-10-08" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>G5EB35</accession>
    <accession>C8VLR5</accession>
    <name>G5EB35_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">RecQ-like DNA helicase BLM</fullName>
            <ecNumber evidence="17">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">ANIA_02087</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="25" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="25">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="17"/>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF86151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_659691.1">
        <property type="nucleotide sequence ID" value="XM_654599.2"/>
    </dbReference>
    <dbReference type="STRING" id="227321.G5EB35"/>
    <dbReference type="GeneID" id="2875310"/>
    <dbReference type="KEGG" id="ani:ANIA_02087"/>
    <dbReference type="eggNOG" id="KOG0351">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001103_16_3_1"/>
    <dbReference type="InParanoid" id="G5EB35"/>
    <dbReference type="OMA" id="MISKSHA"/>
    <dbReference type="OrthoDB" id="10261556at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd17920">
        <property type="entry name" value="DEXHc_RecQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18794">
        <property type="entry name" value="SF2_C_RecQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000537">
        <property type="entry name" value="Bloom syndrome RecQ-like helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000340">
        <property type="entry name" value="Bloom syndrome, RecQ helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000495">
        <property type="entry name" value="RecQ family helicase MusN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.80:FF:000020">
        <property type="entry name" value="RecQ family helicase MusN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.80">
        <property type="entry name" value="HRDC domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004589">
        <property type="entry name" value="DNA_helicase_ATP-dep_RecQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002121">
        <property type="entry name" value="HRDC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044876">
        <property type="entry name" value="HRDC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032284">
        <property type="entry name" value="RecQ_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018982">
        <property type="entry name" value="RQC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00614">
        <property type="entry name" value="recQ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF153">
        <property type="entry name" value="RECQ-LIKE DNA HELICASE BLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16124">
        <property type="entry name" value="RecQ_Zn_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09382">
        <property type="entry name" value="RQC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00956">
        <property type="entry name" value="RQC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="HRDC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50967">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="13" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0347">Helicase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="22">
        <location>
            <begin position="709"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="23">
        <location>
            <begin position="914"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="domain" description="HRDC" evidence="21">
        <location>
            <begin position="1310"/>
            <end position="1395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="192"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="318"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="534"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="595"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1223"/>
            <end position="1253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1452"/>
            <end position="1534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="192"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="1223"/>
            <end position="1234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="1239"/>
            <end position="1250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="20">
        <location>
            <begin position="1475"/>
            <end position="1504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00073450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="CBF86151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="1534" mass="172540" checksum="705F553A7D34A684" modified="2011-12-14" version="1">MTRSNLKTHLKWLLDQGPSLYPVLTPLAWDTHVNPTGSQNNPVPILNLIESHQELSIKDSQPILESAINDPAGNVIDIESDKDMPRLMLDHGLSASKPRMLSAEELHNSARKASKSSSVRQEVSQTPRNKMVEELPSTIPSFRDRKEQAIPPVRPKRKLDIPSSFQDIDTIDLTEDFDSNALSSEIRKEFDELHRRQTEDAAPRTNLTNKRGKKRKSDEEASDFLPLREPTRRACSPPVSSKTVQSDRYISNFVPRAILRDEVPAFRQKKQEDSHLTAPDRAVSVAESDVESIGSLFDLVETKQSSPYVTKKSLYAALPSEEHSSTQQPSLPPSPEPEEPISPDSMDIPETARSTALCPGSTKPHSSHALLPPQSDAEPRNQGVERFLQVPAESLRRLVTCLEDTIKKNSGIVYQGMLNGENTSELHAIVSKNGTLTAQIRAVKALTAQKSAYLSREAESKALKDVIMHALNQGTSDVLPKIEQQKELTSQLKDMEANMCLLLREADLFSVMKEFSLETREIELERLHSLPATTAPSILGGAENKSYRNSPVANNSAFRPDYDARETRLVTSNHRTSSFTGSLGIPEANRTKNHEVTSDNETTFTGKMGSTLPPVEDSDDFDMDVLDEDILEAADNCQEEQPFTKDRHEPCSRPVFAETSGNVRRLPATQKSQTHGTLWGQHPWTKDVKIALKERFHLRGFRPNQLEAIDSTLSGKDTFVLMPTGGGKSLCYQLPSVISSGSTRGVTLVISPLLSLMQDQVSHLRQNKIKAYLINGDTPSEERQWIMSTLSSHNPETHIELLYITPEMISKSHALTDRIEKLCSIQKLARVVIDEAHCVSQWGHDFRPDYKQIGAFRARIPGVPLMALTATATENVKVDVIHNLRMQGCEVFTQSFNRPNLTYEVRRKGKHAELLDSIADTIKSTYRNKCGIVYCLSRNTCEKVAEALRTNYSIKAEHYHAGLDAETRARTQQRWQAGDVHVIVATIAFGMGIDKPDVRFVIHHSIPKSLEGYYQETGRAGRDGRRSGCYLYFSHRDVSTMQSMIEKNEDSDDVQKGRQTRMLNDVVKYCENANDCRRVQILAYFSESFKRQDCNASCDNCKSGDTFEVQDFSEHASAAIKIVRYFQERNERATLSYCVNIFRGTTKSFRSPEHREAPSFGDGSGIAVGDAERLFRKLHSERALTEENIVNRGNFPIQYVKLGPRASDFESGRRRLRLDVRVSHDGSGRPRGDVGRNYLPQSTNVSSPVRSANRRRLERYRHVDSAANESDTDVDSDGFEKVRIAGRDERKKKIIPGPPITQGDRFDQLDHLHRAVAEDFMVYAKNYCQEVVMDKGLRNQPFSDTILREMVMVFPKGKNKGEMLQIPNIDPDKVHRYGDKILKLLRDTKQRLSELKQAGDDVDGVVPDPNHHNVVNISDDEFSDADDVFMYEDDILQPDDTIITSEYFSKSQQPFQDDSGDEYHPSPKSSISKSQKQKNTSKRPPRRKSGGAKQRAKGTRKPKTSSRSQGRSNSRKETKGRQKQPTGQIGMMPI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-01-16" modified="2026-01-28" version="129" xmlns="https://uniprot.org/uniprot">
    <accession>Q00770</accession>
    <accession>C8VKJ7</accession>
    <accession>O42828</accession>
    <accession>Q5BC34</accession>
    <name>FAAA_EMENI</name>
    <protein>
        <recommendedName>
            <fullName>Fumarylacetoacetase</fullName>
            <shortName>FAA</shortName>
            <ecNumber evidence="2">3.7.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Beta-diketonase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Fumarylacetoacetate hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">fahA</name>
        <name type="synonym">fah</name>
        <name type="ORF">AN1896</name>
    </gene>
    <organism>
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1995" name="Proc. Natl. Acad. Sci. U.S.A." volume="92" first="9132" last="9136">
            <title>Fungal metabolic model for human type I hereditary tyrosinaemia.</title>
            <authorList>
                <person name="Fernandez-Canon J.M."/>
                <person name="Penalva M.A."/>
            </authorList>
            <dbReference type="PubMed" id="7568087"/>
            <dbReference type="DOI" id="10.1073/pnas.92.20.9132"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>INDUCTION</scope>
        <scope>MISCELLANEOUS</scope>
        <source>
            <strain>biA1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1998" name="J. Biol. Chem." volume="273" first="329" last="337">
            <title>Characterization of a fungal maleylacetoacetate isomerase gene and identification of its human homologue.</title>
            <authorList>
                <person name="Fernandez-Canon J.M."/>
                <person name="Penalva M.A."/>
            </authorList>
            <dbReference type="PubMed" id="9417084"/>
            <dbReference type="DOI" id="10.1074/jbc.273.1.329"/>
        </citation>
        <scope>SEQUENCE REVISION TO 67-68</scope>
        <scope>PROBABLE FUNCTION</scope>
        <source>
            <strain>biA1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Use of phenylalanine and phenylacetate as a carbon source.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>4-fumarylacetoacetate + H2O = acetoacetate + fumarate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10244"/>
            <dbReference type="ChEBI" id="CHEBI:13705"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18034"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="EC" id="3.7.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text>Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 6/6.</text>
    </comment>
    <comment type="induction">
        <text evidence="2">By phenylacetate (PhoAc), 2OH-PhoAc, 3OH-PhoAc, 4OH-PhoAc, phenylalanine, and tyrosine. Not induced by acetate or glutamate. Expression is partially repressed by glucose.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="4">Disruption of the fahA gene results in phenylalanine toxicity, secretion of succinylacetone and the absence of growth. This is analogous to the genetic disease, type I hereditary tyrosinemia in humans.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FAH family.</text>
    </comment>
    <dbReference type="EC" id="3.7.1.2" evidence="2"/>
    <dbReference type="EMBL" id="L41670">
        <property type="protein sequence ID" value="AAA85778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AJ001836">
        <property type="protein sequence ID" value="CAA05043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AACD01000029">
        <property type="protein sequence ID" value="EAA65061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF85777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_659500.1">
        <property type="nucleotide sequence ID" value="XM_654408.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q00770"/>
    <dbReference type="SMR" id="Q00770"/>
    <dbReference type="STRING" id="227321.Q00770"/>
    <dbReference type="EnsemblFungi" id="CBF85777">
        <property type="protein sequence ID" value="CBF85777"/>
        <property type="gene ID" value="ANIA_01896"/>
    </dbReference>
    <dbReference type="GeneID" id="2874818"/>
    <dbReference type="KEGG" id="ani:ANIA_01896"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN1896"/>
    <dbReference type="eggNOG" id="KOG2843">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026207_2_0_1"/>
    <dbReference type="InParanoid" id="Q00770"/>
    <dbReference type="OMA" id="YWTAAQQ"/>
    <dbReference type="OrthoDB" id="9971669at2759"/>
    <dbReference type="BioCyc" id="MetaCyc:MONOMER-12048"/>
    <dbReference type="UniPathway" id="UPA00139">
        <property type="reaction ID" value="UER00341"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004334">
        <property type="term" value="F:fumarylacetoacetase activity"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902000">
        <property type="term" value="P:homogentisate catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006572">
        <property type="term" value="P:L-tyrosine catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.230:FF:000001">
        <property type="entry name" value="Fumarylacetoacetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.850.10:FF:000009">
        <property type="entry name" value="Fumarylacetoacetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.230">
        <property type="entry name" value="Fumarylacetoacetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="entry name" value="Fumarylacetoacetase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005959">
        <property type="entry name" value="Fumarylacetoacetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015377">
        <property type="entry name" value="Fumarylacetoacetase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036462">
        <property type="entry name" value="Fumarylacetoacetase_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01266">
        <property type="entry name" value="fum_ac_acetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43069">
        <property type="entry name" value="FUMARYLACETOACETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43069:SF2">
        <property type="entry name" value="FUMARYLACETOACETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09298">
        <property type="entry name" value="FAA_hydrolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="FAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63433">
        <property type="entry name" value="Fumarylacetoacetate hydrolase, FAH, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0106">Calcium</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0585">Phenylalanine catabolism</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0828">Tyrosine catabolism</keyword>
    <feature type="chain" id="PRO_0000156828" description="Fumarylacetoacetase">
        <location>
            <begin position="1"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="362"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="sequence conflict" description="In Ref. 2; CAA05043." evidence="3" ref="2">
        <original>NQ</original>
        <variation>KE</variation>
        <location>
            <begin position="67"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; AAA85778 and 2; CAA05043." evidence="3" ref="1 2">
        <original>H</original>
        <variation>R</variation>
        <location>
            <position position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P35505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="7568087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <evidence type="ECO:0000305" key="4">
        <source>
            <dbReference type="PubMed" id="7568087"/>
        </source>
    </evidence>
    <sequence length="431" mass="46977" checksum="A0757E4FDEEFB190" modified="2009-05-26" version="3">MASWLQIPKNSPFSLANIPFGIISSSKLSSRVPAIAIGDYALDLSKFASSGGFSQLPVIQPHLNVFNQSTLNAFAALGRPVHRQVREYIQKVFSTETPFPQILRDNAALQKEALLPLSEVTNHLPMQIGDYTDFYAGLNHAYNVGVLFRGPDNALQPNYKHLPVAYHGRASSVVTSGTPLHRPQGQILTNPAANPKLPTFSPCKKLDIELELAFFVSTPNDLGHPVHIDKAEDHIFGVVLMNDWSARDIQAWEYVPLGPFNAKNFGTTITPWVVLIDALEPFRTVGLEPGNRESLLPYLREKRADTAYDIPLEVEVTNAGGEPTVISHSNAKNLLYSFPQMLAHHTITGCNLNTGDLLGSGTISGKENQTEGSFLEQTNGKNPIKLADGSERLFLEDGDTVILRGMAGTEGNYVGFGDCAGTILPPVQLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ARK2</accession>
    <accession>C8VH69</accession>
    <name>Q5ARK2_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH:ubiquinone oxidoreductase kD subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_09078</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF82595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_682347.1">
        <property type="nucleotide sequence ID" value="XM_677255.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ARK2"/>
    <dbReference type="STRING" id="227321.Q5ARK2"/>
    <dbReference type="GeneID" id="2867976"/>
    <dbReference type="KEGG" id="ani:ANIA_09078"/>
    <dbReference type="eggNOG" id="ENOG502S52G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100674_0_1_1"/>
    <dbReference type="InParanoid" id="Q5ARK2"/>
    <dbReference type="OMA" id="GEPCHED"/>
    <dbReference type="OrthoDB" id="2014058at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008699">
        <property type="entry name" value="NDUFB8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12840:SF1">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 8, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12840">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE ASHI SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05821">
        <property type="entry name" value="NDUF_B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF82595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="152" mass="17087" checksum="FC09449901912CD7" modified="2005-04-26" version="1">MLAQRLLSRRLPQVALRSTVPRASFSQVRALKAAENDDPLMNGGYQNPPRIKRQFRDPNADWWDKQERRNFGEPVHEENEILGVFSPEQYTHVTARKGLLQLGAFVVTFLGLCGAVSLFYPDKPSAPRTFPDGLEKELGGPNALPVGYDPRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="107" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ARN0</accession>
    <accession>C8VKP8</accession>
    <name>Q5ARN0_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Zn(II)2Cys6 transcription factor (Eurofung)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ANIA_09050</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF84390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_682319.1">
        <property type="nucleotide sequence ID" value="XM_677227.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ARN0"/>
    <dbReference type="STRING" id="227321.Q5ARN0"/>
    <dbReference type="GeneID" id="2868170"/>
    <dbReference type="KEGG" id="ani:ANIA_09050"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN9050"/>
    <dbReference type="eggNOG" id="ENOG502SQ3E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011409_3_0_1"/>
    <dbReference type="InParanoid" id="Q5ARN0"/>
    <dbReference type="OMA" id="YNKAIQH"/>
    <dbReference type="OrthoDB" id="2593732at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052360">
        <property type="entry name" value="Transcr_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206:SF16">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="13"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBF84390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="538" mass="60467" checksum="A81349D6E226980C" modified="2005-04-26" version="1">MAKRKSTPRTRSGCRTCKVRRVKCDEQRPSCRRCLDTGRACDGYGIWGQPKSTRLLPSPVYPLRTLPGLAEEERRCLDRFRVLLTDKLTRPFGSHFWSSLVLQLSVSEPAVLHASIALTSAYDSFALAQIRENVAMVAPAPFLLRQYNYAIRALLTNGALESATSVRVATVSCILFICLEILRGNLDAMKVHFAAGIRLLYQLQRQSHRSAATTGTVLVKHDPELFDDHIIEVFARLNLQFLMLGHGPQQKESFVPSFRYGRASYLPRRFSAADEARQALSPILLSVMHLVMQVERLTRSTHAHPPSPSAVMLEEQKSLQAAVEDWIASYDNSIQSAFASVARQHRLALLMLRTYADVAIILLSTCFTVKETAYDAHLHVFKSIIQRYSDVHSTDCPLQSDTCEVDPTFMIDSGLFPPLYFTALKCRNHATRHQALAILRQYVHMEGPWTGPMLARVAGHVVNLEERHFGDILAKATMSTTVSTVLPEFSRIHCVECKLPAQRHQGSNIASLILRRFRHELGSAASWWIDKCTIDLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="106" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ASA2</accession>
    <accession>C8V9K5</accession>
    <name>Q5ASA2_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Trafficking protein particle complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ANIA_08828</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="6">Part of the multisubunit transport protein particle (TRAPP) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Golgi apparatus</location>
            <location evidence="6">cis-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAPP small subunits family. BET5 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF77934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_682097.1">
        <property type="nucleotide sequence ID" value="XM_677005.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ASA2"/>
    <dbReference type="FunCoup" id="Q5ASA2">
        <property type="interactions" value="487"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5ASA2"/>
    <dbReference type="GeneID" id="2868336"/>
    <dbReference type="KEGG" id="ani:ANIA_08828"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN8828"/>
    <dbReference type="eggNOG" id="KOG3368">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053380_4_0_1"/>
    <dbReference type="InParanoid" id="Q5ASA2"/>
    <dbReference type="OMA" id="GKLMYGM"/>
    <dbReference type="OrthoDB" id="3364529at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030008">
        <property type="term" value="C:TRAPP complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990070">
        <property type="term" value="C:TRAPPI protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990071">
        <property type="term" value="C:TRAPPII protein complex"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990072">
        <property type="term" value="C:TRAPPIII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0000305"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043087">
        <property type="term" value="P:regulation of GTPase activity"/>
        <property type="evidence" value="ECO:0000305"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="CDD" id="cd14855">
        <property type="entry name" value="TRAPPC1_MUM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.70:FF:000013">
        <property type="entry name" value="TRAPP complex subunit, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007233">
        <property type="entry name" value="TRAPPC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23249">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23249:SF16">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04099">
        <property type="entry name" value="Sybindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01399">
        <property type="entry name" value="Sybindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3 6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="4 6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="30"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBF77934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="167" mass="19022" checksum="85E2B49843EC6283" modified="2005-04-26" version="1">MTVYSFYIFDRHAECIYKRRWLPRPASIVGKSSRPTSDTLTAANGIAPVPNQSARSTDDDAKLIFGTVFALRNMVRKLGGEDDNFVTYRTSQYKLHYYETLTNIKFVMITDVKSPSMRVALQQIYINLYVEYVVKNPLSPTEHPGGVGVNNELFEQSLEQFVTRVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="107" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ASI7</accession>
    <accession>C8V9Z9</accession>
    <name>Q5ASI7_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">sn-1-specific diacylglycerol lipase</fullName>
            <ecNumber evidence="14">3.1.1.116</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">ANIA_08743</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="18">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a 1,2-diacyl-sn-glycerol + H2O = a 2-acylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33275"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17389"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="EC" id="3.1.1.116"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:33276"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.1.1.116" evidence="14"/>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF78118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_682012.1">
        <property type="nucleotide sequence ID" value="XM_676920.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ASI7"/>
    <dbReference type="ESTHER" id="emeni-q5asi7">
        <property type="family name" value="Lipase_3"/>
    </dbReference>
    <dbReference type="GeneID" id="2868440"/>
    <dbReference type="KEGG" id="ani:ANIA_08743"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN8743"/>
    <dbReference type="eggNOG" id="KOG2088">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001871_0_0_1"/>
    <dbReference type="InParanoid" id="Q5ASI7"/>
    <dbReference type="OMA" id="SWKVHKG"/>
    <dbReference type="OrthoDB" id="438440at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016298">
        <property type="term" value="F:lipase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019369">
        <property type="term" value="P:arachidonate metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046340">
        <property type="term" value="P:diacylglycerol catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052214">
        <property type="entry name" value="DAG_Lipase-Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45792">
        <property type="entry name" value="DIACYLGLYCEROL LIPASE HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45792:SF7">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_6G02710)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Fungal lipase-type" evidence="16">
        <location>
            <begin position="823"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="388"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="457"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="754"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="409"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="515"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="580"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="594"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="615"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="634"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="761"/>
            <end position="775"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00026104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CBF78118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="1152" mass="125817" checksum="ACBEE3B1AFFECCDB" modified="2005-04-26" version="1">MPRILGFGSRSKQNDIEATGSDSHEGASYTPTISGTSLLPGPVASLVSFVAQSTSLSLRVGTYFGGVALDGARITTLTGLELSRTVIEGILTRAGRDIAVRSSGSYGKAEAESILERSLAALHTTITSASFFAAASFQFSSTTLSSASNMSQALLSTLDAILGSTESSRAIAAIITLIRKEFREQSAESGSEKVGVGDLLVGTVGFAMLQRWGRKNTERHIRLNGGLETVWDVVILDNGIRADVLDMQQIQPVNNRPEIMRNRSRRSSFVTPGNAEDEFDVVERPETAIDDSKPPSVIIPDVQHHISDEEIRMYILKQLPRGCRASIKTDTVTTQTITVNVYDDDGEIVAPPGTMVVEERFYNHTDDGGQGSSVGQAPKHTIVFRTAFNRSQSADVRPPSRNLVGLREPNNDHSDDHHHVLSDDSAFEVGPEDTCHISDRVSKSQGQDNQQSVSVFSEVHDPGTPHPSPRETPQSARRVSGTFGRGSLTKFAQRVKTGTSEKKDQSKRSSLRLPFQQSNPHLTPSVSTQRSKPRGAATERKPSAQAYPDKPTRQLKAGKSVVPSMSETAHLTANRGVPRTLSQNHRSQHSSSTNKRDGRTAGPRDDYYWVHESSQESYVTRTDTYSPSRELRPSSPTAASSYVRSSSSLSLTRSESETTVNLRPDKRPNSAHRRSKSYSASIYSLATAGSDTSLILAHRARKSAYDDASTIQALNRDGLVPGIFPKRHFVRNIRRFCRFASATYGASALQVMGLPRQPRGPNRDNPHSQEHDDFSHHTGLPASAILLSSYVDPAGGSNAAGETESGFPLVHYLFLDHESKAVVLALRGTWGFEDVLTDMTCEYDDLVWQGKNWKVHKGMHASAKHLLMGGGRRVMITIRAALEEFPDYGVVLCGHSLGGGVAALLATMISEPTHEASLVSFTTASRSDRKLILPNARFTDDSHPAYYLPPGRPIHVYAYGPPAAMSPFLRRATRGLVTTVVNGQDVVPCLSLGILHDLHTTALEFKGDTSEAKSNVRLRVWENLRQSIVNKFYVHEAPMLLNAGDGLGEDAWAWKTLKSLRESMCAPKLVPPGEVFVVETMRVLQRSAFTSDVGEDGSLRLGKPATRVQLKFIRDVESRFGELRFGSGMFSDHNPARYEASLVALTRGILDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="106" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AU16</accession>
    <accession>C8V779</accession>
    <name>Q5AU16_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Queuine tRNA-ribosyltransferase accessory subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Queuine tRNA-ribosyltransferase domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ANIA_08214</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Non-catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Heterodimer of a catalytic subunit and an accessory subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the queuine tRNA-ribosyltransferase family. QTRT2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF74123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_681483.1">
        <property type="nucleotide sequence ID" value="XM_676391.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AU16"/>
    <dbReference type="STRING" id="227321.Q5AU16"/>
    <dbReference type="GeneID" id="2869064"/>
    <dbReference type="KEGG" id="ani:ANIA_08214"/>
    <dbReference type="eggNOG" id="KOG3909">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037350_1_0_1"/>
    <dbReference type="InParanoid" id="Q5AU16"/>
    <dbReference type="OMA" id="VPHIAHD"/>
    <dbReference type="OrthoDB" id="27601at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008479">
        <property type="term" value="F:tRNA-guanosine(34) queuine transglycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.105:FF:000007">
        <property type="entry name" value="Queuine tRNA-ribosyltransferase accessory subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.105">
        <property type="entry name" value="Queuine tRNA-ribosyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03043">
        <property type="entry name" value="QTRT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028592">
        <property type="entry name" value="QTRTD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050852">
        <property type="entry name" value="Queuine_tRNA-ribosyltrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036511">
        <property type="entry name" value="TGT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002616">
        <property type="entry name" value="tRNA_ribo_trans-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00449">
        <property type="entry name" value="tgt_general"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46064">
        <property type="entry name" value="QUEUINE TRNA-RIBOSYLTRANSFERASE ACCESSORY SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46064:SF1">
        <property type="entry name" value="QUEUINE TRNA-RIBOSYLTRANSFERASE ACCESSORY SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01702">
        <property type="entry name" value="TGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51713">
        <property type="entry name" value="tRNA-guanine transglycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNA-guanine(15) transglycosylase-like" evidence="7">
        <location>
            <begin position="16"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="393"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="428"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="442"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="320"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="323"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="349"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBF74123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="451" mass="49212" checksum="E03E9251EDD2D435" modified="2005-04-26" version="1">MLNFSISRSSAAVLSPRLGRLTIAGRKPILTPHYIPLTSRGVVPHLAHDVMRDNTSIGSLYIGLEDFPTAPHESALRKFICAADDLLLVFGARREPPIASGPANTDTSIAVLTSVGYAQLEANEYVGAIQRLSPDIVVGLADLLVGQKPGTKRRVKMVDRTHAFTTHATDNLYGPQLSEHSRSTAAYFAPILPLENTQQQLYLEDLETDLRPSISGLALYEPTSLSIVPESLGDLPRLLFSGPRTPHDLLREVELGADLLTIPFLADSSDAGMAFTFSFPAPSDTASASNPSTEPLPLADDLWSRSNTTNTGPLSESCACYACQSHHRAYIHHLLSAKEMLAWTLLQIHNYYTMDLFFANVRKSIERGTFEADVRTFQQTYVAEFPEITGQGPRLRGYKIPTSGPAQPRRNPPAYGRLNVAAEKFVESQSDLATPDTGAEGLEEHGFAEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="118" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AU27</accession>
    <accession>C8V768</accession>
    <name>Q5AU27_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glutamine-dependent NAD(+) synthetase</fullName>
            <ecNumber evidence="7">6.3.5.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">NAD(+) synthase [glutamine-hydrolyzing]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ANIA_08203</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11 7">
            <text>deamido-NAD(+) + L-glutamine + ATP + H2O = L-glutamate + AMP + diphosphate + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24384"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from deamido-NAD(+) (L-Gln route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">In the C-terminal section; belongs to the NAD synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.1" evidence="7"/>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF74102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_681472.1">
        <property type="nucleotide sequence ID" value="XM_676380.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AU27"/>
    <dbReference type="FunCoup" id="Q5AU27">
        <property type="interactions" value="718"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5AU27"/>
    <dbReference type="GeneID" id="2869198"/>
    <dbReference type="KEGG" id="ani:ANIA_08203"/>
    <dbReference type="eggNOG" id="KOG2303">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011884_2_0_1"/>
    <dbReference type="InParanoid" id="Q5AU27"/>
    <dbReference type="OMA" id="TSQEVCN"/>
    <dbReference type="OrthoDB" id="2020662at2759"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00334"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003952">
        <property type="term" value="F:NAD+ synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD+ biosynthetic process from L-tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD+ biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd07570">
        <property type="entry name" value="GAT_Gln-NAD-synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00553">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000036">
        <property type="entry name" value="Glutamine-dependent NAD(+) synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.110.10:FF:000038">
        <property type="entry name" value="Glutamine-dependent NAD(+) synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02090">
        <property type="entry name" value="NadE_glutamine_dep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014445">
        <property type="entry name" value="Gln-dep_NAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003694">
        <property type="entry name" value="NAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23090:SF9">
        <property type="entry name" value="GLUTAMINE-DEPENDENT NAD(+) SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23090">
        <property type="entry name" value="NH 3 /GLUTAMINE-DEPENDENT NAD + SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006630">
        <property type="entry name" value="NADS_GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 7" id="KW-0520">NAD</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="8">
        <location>
            <begin position="5"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR006630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBF74102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="678" mass="76189" checksum="8F2A4CB6817347A6" modified="2005-04-26" version="1">MGRLITLATCSLNQWALDWEGNCERIIESIRQAKAAGATLRVGPELEITGYGVLDGFLEGDTFLHSWEMLARIIDHPDCQDIVVDVDGNYREMRHFTPWQRPREVEDYYLEQIVGKITGQYKVPFGDAVISTRDTCLGLETCEELFTPNGPHIPYSLAGVEIISNSSGSHHELKKLDTRVNLITQATKLSGGIYLYANQQGCDGDRLYYDGCAMIVINGNIVAQGSQFSLNDVEVVTATVDIEEVRTYRASTSRNMQASRQPPFVRLDLDTRLSRSDEDADPGIAPSETLIPRYHAPEEEIALGPACWLWDYLRRSGAAGFFLPLSGGIDSCATAVIVHSMCREVIKAVQQGNEQVIKDVRRLCAEPAGSTWLPTTSQEVCNFMGTQNSSKETRDRAKELAAEIGSYHIDFNFDTVVTALMNLFTVVTNFQPRFKVHGGSRAENQALQNIQARLRMVLSYLFASLLPTVRQRPGGGGLLVLASSNVDECLRGYLTKYDASSADLNPIGSISKVDLKKFIGHCATSFDMPILTSFLNATPTAELEPITATYVQSDEADMGVTYAELGTFGYLRKVSKLGPWSMYERLLHMWGNEYSPREIYEKTRHFFYNYAINRHKMTVITPSYHAEQYSPDDNRHDLRQFLYPPFTWAYKKMEESVKYWEERGWTTGKAQKKSVKAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="100" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AUG7</accession>
    <accession>C8V678</accession>
    <name>Q5AUG7_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ANIA_08063</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF73809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_681332.1">
        <property type="nucleotide sequence ID" value="XM_676240.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AUG7"/>
    <dbReference type="STRING" id="227321.Q5AUG7"/>
    <dbReference type="GeneID" id="2868929"/>
    <dbReference type="KEGG" id="ani:ANIA_08063"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN8063"/>
    <dbReference type="eggNOG" id="ENOG502RCH9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023111_1_0_1"/>
    <dbReference type="InParanoid" id="Q5AUG7"/>
    <dbReference type="OMA" id="YIFHRHG"/>
    <dbReference type="OrthoDB" id="258392at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF142">
        <property type="entry name" value="PHOSPHOGLYCERATE MUTASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030175727" evidence="3">
        <location>
            <begin position="20"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="425"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBF73809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="473" mass="50686" checksum="BEE39E390DC5E722" modified="2005-04-26" version="1">MRRSLQLIALSAIPLQVSAEKVLGAYIFARHGDRTAKILKNTQLTDLGYNQVYLTGSAYHDRYINSTSSKYIDGISEDVVNLSQLTASAPADAVLQNSATGFLQGVYPPVGSVSSQELANGTTVESPLNGYQLIPLSLIDSGASSEDSTWLQGTTDCNRAKVSSDSYYESELYKTLFEETKDFYQSLSPLINTSFSDADMSFRNAYSIYDYLNVGSIHNTSNTPTESQLHQAFLLANIEQYNLAYNSSETVRAIAGSTLAAEMLMGLNETVTSQGEVKLHLEFGSYGTFLSYFGLANLPAVDAAFTGIPDYASSMVWELVTNSTSDSFPSTDEISVRFAFHNGTMTGSSSTPTTYPLYGQSSSTIPWSTFVEQTEKIAVMTTQQWCDVCGNTDGQCASSSDTSDSGNASTNSFAGSNGGGISKGVAGVIGAMVTLAVILGLEALFLLLGPFRLSKKGRLAGIDRGNVVDENKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="112" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AUT2</accession>
    <accession>C8V583</accession>
    <name>Q5AUT2_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ANIA_07948</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF73579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_681217.1">
        <property type="nucleotide sequence ID" value="XM_676125.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AUT2"/>
    <dbReference type="STRING" id="227321.Q5AUT2"/>
    <dbReference type="GeneID" id="2868896"/>
    <dbReference type="KEGG" id="ani:ANIA_07948"/>
    <dbReference type="eggNOG" id="KOG4389">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006586_10_6_1"/>
    <dbReference type="InParanoid" id="Q5AUT2"/>
    <dbReference type="OMA" id="NEGAWEF"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050654">
        <property type="entry name" value="AChE-related_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918">
        <property type="entry name" value="ACETYLCHOLINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918:SF4">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010392551" description="Carboxylic ester hydrolase" evidence="3">
        <location>
            <begin position="22"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="98"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBF73579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="482" mass="53046" checksum="D4A755AC39A47443" modified="2005-04-26" version="1">MRVLYLACSLAGFALMGKTQASLRNYPVAETTNGSYKDVYLPHYDQDLFLDIPSAQPPIEIRRFRNPEPLTTDWTGERPSTKYAFVNSVKFNKPMNAVSIAYRLGPYGFFNGNEVAAEKALNLGLKDQRLALHWIQENIAGFGGDPRKLTIYGQSAGAEGVGYHLRAFNGRDDGLFRAAIMQSGPVIPQGPLSLTASYQYRYEGVVAEEGCSHADHKLDCLRALPFAVLNNVLNSSAYNTGWGPTVDGDFVARYTSEQVDDGSFARVPIIAGTTTDEGSTQSPKPVNTTEELRGWMNTTSSYQLALPKSSINALLTLYPNTTTFGIPSSAELGGNVTLPQPYGAAFRRSAAYFGDQVFTASRRKTCQAWAAHALSAYCYRFNTKPTTTSWVEGVAHFSDVAFVFNNLNGQGYDVNPFAMGNLTHKYIELSYLMAGSWASFVSDLDPIRGEARGEMPLGLWAESLAGRYRRLIGRAIWFSMRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AUW2</accession>
    <accession>C8V4V8</accession>
    <name>Q5AUW2_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-haloalkanoic acid dehalogenase, putative (AFU_orthologue AFUA_8G05870)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_07918</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF73520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_681187.1">
        <property type="nucleotide sequence ID" value="XM_676095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AUW2"/>
    <dbReference type="STRING" id="227321.Q5AUW2"/>
    <dbReference type="GeneID" id="2869056"/>
    <dbReference type="KEGG" id="ani:ANIA_07918"/>
    <dbReference type="eggNOG" id="ENOG502S2N3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045011_2_0_1"/>
    <dbReference type="InParanoid" id="Q5AUW2"/>
    <dbReference type="OMA" id="CVQGYSE"/>
    <dbReference type="OrthoDB" id="2363873at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051540">
        <property type="entry name" value="S-2-haloacid_dehalogenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43316:SF4">
        <property type="entry name" value="ACID DEHALOGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05870)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43316">
        <property type="entry name" value="HYDROLASE, HALOACID DELAHOGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF73520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="242" mass="27256" checksum="D3F9080B069F26B9" modified="2005-04-26" version="1">MTTARKHVVFDVVGTCVSFDAYFNAIDRVLGDRLRANNITPQFFGYSWMTAAELEFTFLSISERHRPYKHILEAVFYRTLHMAGVKDPRALATETERDECIQGYWSLQLRPGISECFAKLRESGFAIWCLTTGDIARVKGYFERGGVDLPAENIISCDSKGVAKPALDAYRPVFEQFAPRDEKWFAAAHMWDVSAAVKVGFRGAYCTVYEQDPCLVIFDTKMDVIADSLVDMAEEIVKASAS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2010-04-20" modified="2025-04-09" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AUX2</accession>
    <accession>C8V4U9</accession>
    <name>AXHA2_EMENI</name>
    <protein>
        <recommendedName>
            <fullName>Alpha-L-arabinofuranosidase axhA-2</fullName>
            <ecNumber>3.2.1.55</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Arabinoxylan arabinofuranohydrolase axhA-2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">axhA-2</name>
        <name type="ORF">AN7908</name>
    </gene>
    <organism>
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="11417" last="11422">
            <title>Development and application of a suite of polysaccharide-degrading enzymes for analyzing plant cell walls.</title>
            <authorList>
                <person name="Bauer S."/>
                <person name="Vasu P."/>
                <person name="Persson S."/>
                <person name="Mort A.J."/>
                <person name="Somerville C.R."/>
            </authorList>
            <dbReference type="PubMed" id="16844780"/>
            <dbReference type="DOI" id="10.1073/pnas.0604632103"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>BIOPHYSICOCHEMICAL PROPERTIES</scope>
    </reference>
    <comment type="function">
        <text evidence="1 3">Alpha-L-arabinofuranosidase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose. Releases L-arabinose from arabinoxylan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>Hydrolysis of terminal non-reducing alpha-L-arabinofuranoside residues in alpha-L-arabinosides.</text>
            <dbReference type="EC" id="3.2.1.55"/>
        </reaction>
    </comment>
    <comment type="biophysicochemical properties">
        <phDependence>
            <text evidence="3">Optimum pH is 5.4.</text>
        </phDependence>
        <temperatureDependence>
            <text evidence="3">Optimum temperature is 47 degrees Celsius.</text>
        </temperatureDependence>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location>Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyl hydrolase 62 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.55"/>
    <dbReference type="EMBL" id="AACD01000135">
        <property type="protein sequence ID" value="EAA59562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF73503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_681177.1">
        <property type="nucleotide sequence ID" value="XM_676085.1"/>
    </dbReference>
    <dbReference type="PDB" id="5UBJ">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.70 A"/>
        <property type="chains" value="A=1-325"/>
    </dbReference>
    <dbReference type="PDBsum" id="5UBJ"/>
    <dbReference type="AlphaFoldDB" id="Q5AUX2"/>
    <dbReference type="SMR" id="Q5AUX2"/>
    <dbReference type="STRING" id="227321.Q5AUX2"/>
    <dbReference type="CAZy" id="GH62">
        <property type="family name" value="Glycoside Hydrolase Family 62"/>
    </dbReference>
    <dbReference type="GlyCosmos" id="Q5AUX2">
        <property type="glycosylation" value="1 site, No reported glycans"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CBF73503">
        <property type="protein sequence ID" value="CBF73503"/>
        <property type="gene ID" value="ANIA_07908"/>
    </dbReference>
    <dbReference type="KEGG" id="ani:ANIA_07908"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN7908"/>
    <dbReference type="eggNOG" id="ENOG502QUZT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041805_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AUX2"/>
    <dbReference type="OMA" id="AYQWGSS"/>
    <dbReference type="OrthoDB" id="3156236at2759"/>
    <dbReference type="BRENDA" id="3.2.1.55">
        <property type="organism ID" value="517"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019566">
        <property type="term" value="P:arabinose metabolic process"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046373">
        <property type="term" value="P:L-arabinose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08987">
        <property type="entry name" value="GH62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005193">
        <property type="entry name" value="GH62_arabinosidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40631">
        <property type="entry name" value="ALPHA-L-ARABINOFURANOSIDASE AXHA-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40631:SF1">
        <property type="entry name" value="ALPHA-L-ARABINOFURANOSIDASE AXHA-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03664">
        <property type="entry name" value="Glyco_hydro_62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0002">3D-structure</keyword>
    <keyword id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0326">Glycosidase</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0624">Polysaccharide degradation</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <keyword id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000393537" description="Alpha-L-arabinofuranosidase axhA-2">
        <location>
            <begin position="23"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <feature type="strand" evidence="5">
        <location>
            <begin position="32"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="strand" evidence="5">
        <location>
            <begin position="45"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="strand" evidence="5">
        <location>
            <begin position="59"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="strand" evidence="5">
        <location>
            <begin position="73"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="strand" evidence="5">
        <location>
            <begin position="81"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="helix" evidence="5">
        <location>
            <begin position="84"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="strand" evidence="5">
        <location>
            <begin position="92"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="strand" evidence="5">
        <location>
            <begin position="100"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="helix" evidence="5">
        <location>
            <begin position="108"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="strand" evidence="5">
        <location>
            <begin position="112"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="strand" evidence="5">
        <location>
            <begin position="142"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="strand" evidence="5">
        <location>
            <begin position="156"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="strand" evidence="5">
        <location>
            <begin position="165"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="strand" evidence="5">
        <location>
            <begin position="175"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="helix" evidence="5">
        <location>
            <begin position="186"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="strand" evidence="5">
        <location>
            <begin position="198"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="turn" evidence="5">
        <location>
            <begin position="205"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="strand" evidence="5">
        <location>
            <begin position="210"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="strand" evidence="5">
        <location>
            <begin position="225"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="strand" evidence="5">
        <location>
            <begin position="234"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="strand" evidence="5">
        <location>
            <begin position="252"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="turn" evidence="5">
        <location>
            <begin position="265"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="strand" evidence="5">
        <location>
            <begin position="277"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="helix" evidence="5">
        <location>
            <begin position="294"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="strand" evidence="5">
        <location>
            <begin position="298"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="strand" evidence="5">
        <location>
            <begin position="318"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="16844780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PDB" id="5UBJ"/>
        </source>
    </evidence>
    <sequence length="325" mass="35560" checksum="CD0DC28566CB8064" modified="2005-04-26" version="1" precursor="true">MRNLSTWPTFAALLWSAPRVLAQCGLPSTYSWTSTGPLAEPKDGWASLKDFTAVPYNGQYLVYATYHDTGTSWGSMNFGLFSNWSDMATASQNAMTQSTVAPTLFYFEPKDVWILAYQWGPTAFSYLTSSDPTDANGWSSPQPLFSGSISDSDTGVIDQTVIGDSTTMYLFFAGDNGRIYRASMPIDQFPGDFGTESEIILSDERNNLFEAVQVYTVSGQSKDTYLMIVEAIGAQGRYFRSFTADSLGGSWTPQAATESAPFAGKANSGATWTDDISHGDLVRSTPDQTMSIDPCNLQLLYQGRDPSLNPGYDLLPYRPGLLTLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AVF4</accession>
    <accession>C8VDJ0</accession>
    <name>Q5AVF4_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nuclear pore complex protein An-Sac3 (Eurofung)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ANIA_07726</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus envelope</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SAC3 family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_675903.1"/>
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        <property type="entry name" value="80 KDA MCM3-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR12436:SF3">
        <property type="entry name" value="GERMINAL-CENTER ASSOCIATED NUCLEAR PROTEIN"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="138" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AVZ3</accession>
    <accession>C8VBM3</accession>
    <name>Q5AVZ3_EMENI</name>
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        <submittedName>
            <fullName evidence="10">Protein kinase, putative (AFU_orthologue AFUA_6G09240)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ANIA_07537</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF79590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_675714.1"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_000288_63_43_1"/>
    <dbReference type="InParanoid" id="Q5AVZ3"/>
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    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
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    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:001492">
        <property type="entry name" value="Protein kinase, putative (AFU_orthologue AFUA_6G09240)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000676">
        <property type="entry name" value="serine/threonine-protein kinase 32B isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24355">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR KINASE/RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24355:SF30">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE 32B ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="167"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="9">
        <location>
            <begin position="362"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="120"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="469"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="580"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="133"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="469"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="514"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBF79590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="629" mass="69453" checksum="C112B9E077C37B7F" modified="2005-04-26" version="1">MNEKRGGHELWSAMEALQRSQSPFAGKINSQSSNTGCKRPASINFPVASRRTLLFNHISFRPHFSFLPLPKPRPPDNPSTSSLSLLAPPFLHSGLDAVNLQLNPAVRCSFRISVLFPRSPSVNHEQPRPQPVRFSNSYHNSDGRLSQMGNSQGRQVASDNEVNLNQFRLLRVVGKGAFGKVRIVEKKDTGLTFALKYIRKEEEYMCVFTSGDIRTVADFTSYIVVDLMNGGDLRFHISRKCFTEEAVRFWLAELGCALRYIHSQGIIHRDVKPDNVLLDSEGHVHLADFNVASDFRPGKPLTSRSQDTLSENIKKAQPKYYVTNPAVSIPCLRAMSALMEKDRSKRIGAVSFESFTSHQFFADIDFEALERKEVPPVFRPSSDKTNFDATYDLEELLLEEAPLEARARRQKPRAELREDATAKEIREDELHRLIETMFEPFDYTAVTYRGNAAEAIASVANPEDCIQTAASSTHSRHYSQPDSTRGSPARAEGSPSRLTLPDNQSSIGVALEGTTSQPLSPASQTPPPATAPNFARPFVPPAAARARPTARKTSKGGGVQMVLEEAGSWSELADQSATLPAEGFDASGKGKSTNSGMLSFLSRKKGRDRSPKPQEPGVLGKEGARQIIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="120" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AW79</accession>
    <accession>C8VBC6</accession>
    <name>Q5AW79_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD-specific glutamate dehydrogenase</fullName>
            <ecNumber evidence="4">1.4.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ANIA_07451</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">NAD(+)-dependent glutamate dehydrogenase which degrades glutamate to ammonia and alpha-ketoglutarate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>L-glutamate + NAD(+) + H2O = 2-oxoglutarate + NH4(+) + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15133"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.4.1.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the Glu/Leu/Phe/Val dehydrogenases family.</text>
    </comment>
    <dbReference type="EC" id="1.4.1.2" evidence="4"/>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF79408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_680720.1">
        <property type="nucleotide sequence ID" value="XM_675628.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AW79"/>
    <dbReference type="FunCoup" id="Q5AW79">
        <property type="interactions" value="94"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5AW79"/>
    <dbReference type="GeneID" id="2869545"/>
    <dbReference type="KEGG" id="ani:ANIA_07451"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN7451"/>
    <dbReference type="eggNOG" id="KOG2250">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005220_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AW79"/>
    <dbReference type="OMA" id="DEYGMTS"/>
    <dbReference type="OrthoDB" id="184415at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004352">
        <property type="term" value="F:glutamate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019676">
        <property type="term" value="P:ammonia assimilation cycle"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006538">
        <property type="term" value="P:L-glutamate catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006096">
        <property type="entry name" value="Glu/Leu/Phe/Val/Trp_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056365">
        <property type="entry name" value="NAD-GDH_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016210">
        <property type="entry name" value="NAD-GDH_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055480">
        <property type="entry name" value="NAD-GDH_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11606">
        <property type="entry name" value="GLUTAMATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11606:SF24">
        <property type="entry name" value="NAD-SPECIFIC GLUTAMATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00208">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23147">
        <property type="entry name" value="GDH2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23152">
        <property type="entry name" value="GDH_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000184">
        <property type="entry name" value="GDH_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00839">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0520">NAD</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal" evidence="6">
        <location>
            <begin position="731"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBF79408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="1096" mass="123564" checksum="23BC9ECF3E0E3A7D" modified="2005-04-26" version="1">MVSPASSLQSLPDVHVNGNEPNKLPVRSAPKLYGSNDGASSGTGTPIGFQRQPHNKILDSVAGSNVRMPSPQPTHLAIPGSPHRVLSEEDPGYIAAKFEGKEHQMEEVMDQLEKKGFIPPEFIVGETEWFYNQLGIDDTYFQTETVEAIVTQILSLYAAKVAAYARDDKKLEIRLDKEAEDHAVYIDTSKPGFSSVNGPGYEQRIDKKYIDGSTHDHSYRIETFRSPTPVPGDDGQQLRCYFVYKCQFANPNPGPQETNIDIIGEKRFLQKATPNTKAIYQEIISNAVARAGPVIEMFEIEGSREKRLVIAYRQGSAMGLFSALSDLYHYYRLTSSRKYLENFSNGITVISLYLRPLKNAEVAAKFPPIEAAVHQIIKEISLLYCIPQNRFQHHFASGRLSLQETIYAHCAWVFVQQFLNRLGSEYTSLTDLLDSNNSTHAELLAKIKKRLRTETFTSDYIAEIVNKYPDLIHKLYLDFANTHYVQTQGPTEDDFLPTLSYLRLQVDQVLDSRQLKQLVSSTAANEHDEMVMSAFRVFNASILKTNFFTPTKVALSFRLDPHFLPEHEYPQRLYGMFLVISSEFRGFHLRFRDIARGGIRIVKSRNKEAYSINARSLFDENYNLANTQQRKNKDIPEGGAKGVILLDVNHQDKARVAFEKYIDSILDLLLPPASPGIKDPIVDLYGKDEILFMGPDENTAELVDWATEHARNRGAPWWKSFFTGLSPRLGGIPHDTYGMTTLSVRQYVLGIYRKLKIDPSTIRKLQTGGPDGDLGSNEILLANEKYTAIVDGSGVIVDPQGLNREELVRLAKKRATISEFDVSKLSPNGYRVLVDESNVHLPSGELVHNGMVFRNMFHLRKELTYDTFVPCGGRPESIDLSNVGKLIENGKSTIPYIVEGANLFITQDSKLRLEKAGCILFKDASANKGGVTSSSLEVLASLSFDDQGFVQNMCVGDDDSVPEFYREYVKQVQEVIKENATLEFEAIWREHEQTGIPRSVLSDRLSVAITQLDEELQKTELWDNVELRRSVLNDALPKLLLDKIGLDTILQRVPENYLRAIFGSHLASRFVYEYGSSPSQFSFFNFMTKRLAQSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="115" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AWM8</accession>
    <accession>C8VCQ4</accession>
    <name>Q5AWM8_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Lectin family integral membrane protein, putative (AFU_orthologue AFUA_2G16800)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ANIA_07302</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF78663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_680571.1">
        <property type="nucleotide sequence ID" value="XM_675479.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AWM8"/>
    <dbReference type="FunCoup" id="Q5AWM8">
        <property type="interactions" value="152"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5AWM8"/>
    <dbReference type="GeneID" id="2869766"/>
    <dbReference type="KEGG" id="ani:ANIA_07302"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN7302"/>
    <dbReference type="eggNOG" id="ENOG502RYE9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053733_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AWM8"/>
    <dbReference type="OMA" id="WSAEFQF"/>
    <dbReference type="OrthoDB" id="10265193at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005537">
        <property type="term" value="F:D-mannose binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd06903">
        <property type="entry name" value="lectin_EMP46_EMP47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000245">
        <property type="entry name" value="Similar to lectin family integral membrane protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035661">
        <property type="entry name" value="EMP46/EMP47_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051136">
        <property type="entry name" value="Intracellular_Lectin-GPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005052">
        <property type="entry name" value="Lectin_leg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12223:SF28">
        <property type="entry name" value="LECTIN, MANNOSE BINDING 1 LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12223">
        <property type="entry name" value="VESICULAR MANNOSE-BINDING LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03388">
        <property type="entry name" value="Lectin_leg-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51328">
        <property type="entry name" value="L_LECTIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010306785" evidence="9">
        <location>
            <begin position="17"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="386"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="L-type lectin-like" evidence="10">
        <location>
            <begin position="22"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="237"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="316"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="244"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CBF78663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="419" mass="46330" checksum="E3E57BBB5927E79B" modified="2005-04-26" version="1">MKVPALFFFFSAVATAQTVIESSSFGHGAMVAPNREGIPGWDIGGEGHFPQILSNKVILTPPYPGNTRGYAWSQTPLSQSEWAAEFQFRATGVERAGGNLQLWYAKDGKQKIGSASIYTVGQWDGFALVVDTHSGRGGSIRGFLNDGTTDYKSHSSVDSLAFGHCDYSYRNLGRPSVIRVRSTNAIFEVTVDDKPCFATDKITLPAGNTIGVTAATPENPDSFEVFKVVLQTATSPVGKAPPVQAQNTNQQPLADQPQGNARQEQGFSNNLNSINAQFVDLGSRIQLVNHATNNIIRELGNQASKSETRQLELLQRVATKEQVQSLEARLQRMEQTLLSIQRDLEGKDYRDRFNQLHETLRSSHQSLTENLKDNVVSVITASTPRMGFFIFSMIAFQVFLAVSYIIYKRRRANMPKKFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AWW0</accession>
    <accession>C8VCZ5</accession>
    <name>Q5AWW0_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_07220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF78829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_680489.1">
        <property type="nucleotide sequence ID" value="XM_675397.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AWW0"/>
    <dbReference type="GeneID" id="2870021"/>
    <dbReference type="KEGG" id="ani:ANIA_07220"/>
    <dbReference type="eggNOG" id="ENOG502S0SE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_113361_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AWW0"/>
    <dbReference type="OMA" id="WAVGSMR"/>
    <dbReference type="OrthoDB" id="10019049at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF78829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="180" mass="20358" checksum="829B99123284D528" modified="2005-04-26" version="1">MAANPQTYQPIISGPGDIRTAQKRRQIYIRPFLLFWLASLLAETVFLAVGIFVMTGTRDLVYKVLWTLVFCPLGMGGAMGGLINVFIVDHYYGTKAAHFTGVLALLVLSSCNYLCYNLDRHFGWFGASEHPMWFHWRYPMIWAVGSMRQDQISYGSPGEYTVGLKDAFARGNSRARSSWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AX02</accession>
    <accession>C8VD45</accession>
    <name>Q5AX02_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ANIA_07178</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF78921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_664782.1">
        <property type="nucleotide sequence ID" value="XM_659690.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AX02"/>
    <dbReference type="GeneID" id="2869884"/>
    <dbReference type="KEGG" id="ani:ANIA_07178"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN7178"/>
    <dbReference type="eggNOG" id="ENOG502SIKZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_894366_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AX02"/>
    <dbReference type="OMA" id="HCDPFQP"/>
    <dbReference type="OrthoDB" id="9983560at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050432">
        <property type="entry name" value="FAD-linked_Oxidoreductases_BP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878:SF91">
        <property type="entry name" value="FAD BINDING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G12070)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878">
        <property type="entry name" value="GULONOLACTONE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="3">
        <location>
            <begin position="105"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBF78921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="311" mass="34136" checksum="6E5E7E2A29B890FC" modified="2005-04-26" version="1">MRRPVRVSPGRAGTVASSCRATKSGPALTWEIFDLLGGSLIKATPLAAYCYPDWPEYDADKCSEITTNWIISDIRMDDPVSIMLPLYEGRTCIPPGYNYTDTCTQGGYPTYVVNATTVAQIQMAVNFARNPNLRLVVENTGHDFNGKAAGKGALSIWTHWLKDKAFYPEYHADNGYVGPAIKFGAGAQVWEAYEFANENGVSHCHWWRGCDCWSGVGYTASGGHSPLSSLYGMAADQVLSMEGTSLTFFEPISYPLTTQHEIANEMTVVLADGHSSRLPLPKTLPLLSQIICNDSWHTPIPAFNVECQAYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="130" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AX11</accession>
    <accession>C8VD54</accession>
    <name>Q5AX11_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">nitric oxide dioxygenase</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">ANIA_07169</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="20">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">In the presence of oxygen and NADH, it has NADH oxidase activity, which leads to the generation of superoxide and H(2)O(2). Under anaerobic conditions, it also exhibits nitric oxide reductase and FAD reductase activities. However, all these reactions are much lower than NOD activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>2 nitric oxide + NADH + 2 O2 = 2 nitrate + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19469"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16480"/>
            <dbReference type="ChEBI" id="CHEBI:17632"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.14.12.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>2 nitric oxide + NADPH + 2 O2 = 2 nitrate + NADP(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19465"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16480"/>
            <dbReference type="ChEBI" id="CHEBI:17632"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.14.12.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.12.17" evidence="4"/>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF78937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_664773.1">
        <property type="nucleotide sequence ID" value="XM_659681.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AX11"/>
    <dbReference type="FunCoup" id="Q5AX11">
        <property type="interactions" value="326"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5AX11"/>
    <dbReference type="GeneID" id="2870079"/>
    <dbReference type="KEGG" id="ani:ANIA_07169"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN7169"/>
    <dbReference type="eggNOG" id="KOG3378">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003827_12_0_1"/>
    <dbReference type="InParanoid" id="Q5AX11"/>
    <dbReference type="OMA" id="ADIHYEV"/>
    <dbReference type="OrthoDB" id="436496at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008941">
        <property type="term" value="F:nitric oxide dioxygenase NAD(P)H activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071500">
        <property type="term" value="P:cellular response to nitrosative stress"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043942">
        <property type="term" value="P:negative regulation of sexual sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046210">
        <property type="term" value="P:nitric oxide catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009636">
        <property type="term" value="P:response to toxic substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043935">
        <property type="term" value="P:sexual sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045461">
        <property type="term" value="P:sterigmatocystin biosynthetic process"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="CDD" id="cd08922">
        <property type="entry name" value="FHb-globin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06184">
        <property type="entry name" value="flavohem_like_fad_nad_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.490.10:FF:000003">
        <property type="entry name" value="Flavohemoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000034">
        <property type="entry name" value="Flavohemoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000010">
        <property type="entry name" value="Flavohemoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000971">
        <property type="entry name" value="Globin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009805">
        <property type="entry name" value="PRK13289.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43396">
        <property type="entry name" value="FLAVOHEMOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43396:SF3">
        <property type="entry name" value="FLAVOHEMOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00042">
        <property type="entry name" value="Globin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="Globin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01033">
        <property type="entry name" value="GLOBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0216">Detoxification</keyword>
    <keyword evidence="9" id="KW-0274">FAD</keyword>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="12" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-0521">NADP</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Globin" evidence="17">
        <location>
            <begin position="2"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="18">
        <location>
            <begin position="149"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00056398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS01033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CBF78937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="410" mass="44951" checksum="044C8BE6B104F3C4" modified="2005-04-26" version="1">MSLSPEQIQLIKATVPVLQEHGTTITKVFYDNMLTAHPELKTVFNVSNKVHGHQPQALAGALFAYASYIDNLGVLSPAVERICHKHASLAIQPDGYQIVGKFLLEAMGQVLGDALTPPLLEAWAAAYWQLANIMIGKEAELYKSADGWTDFRDFRVARKEPESDVITSFYLEPVDGKPLPSFLPGQYVSIQVQVPQLNHAQCRQYSLSDQPKPTYYRISVRKDLGLDASDPSAPAHPGYVSNILHDNINVGDIVKLTHPYGDFHLTDAAASSPLVLISAGVGLTPMTSMVNTLRTAESNTRPVHFIHGAHTSASRAFQAHLQSLPNLKTTYFLTAPTESDKQGENYTYKGRVDLSKIADEDLFLGDKQTEYYICGPTAFMLDTQKALVARGVDQSRVHMELFGTGGVPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AX58</accession>
    <accession>C8VDA9</accession>
    <name>Q5AX58_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ANIA_07122</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF79037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_664726.1">
        <property type="nucleotide sequence ID" value="XM_659634.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AX58"/>
    <dbReference type="GeneID" id="2869911"/>
    <dbReference type="KEGG" id="ani:ANIA_07122"/>
    <dbReference type="HOGENOM" id="CLU_994075_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AX58"/>
    <dbReference type="OrthoDB" id="4357582at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37535">
        <property type="entry name" value="FLUG DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37535:SF3">
        <property type="entry name" value="FLUG DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF79037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="280" mass="32710" checksum="E1FE3F1674BAC957" modified="2005-04-26" version="1">MLDMSLTPYTTEPVPHFFVSDHIHIKKIQACIWKLSEQYFPVQPGNSRIEEMPTTGTIEEFRRDFETALAREQNFQAPGNISVTIKELWCRDFKEYHGKLPKQSRVQLTALILLYCLSSARTGEFMANCKALGADAFGKEFAVLGSQCGFEQNITVHACRRWALMETAKAEFEFQDCEDILALDKELAELSTQLENTDSAESMREIQLQQQRIQGQKDKLYLGEPKRQYQLQPDNQSRSIHEHMLFYYYQQVMPERDLLADILPARQRYRAWLNWMLSKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AY66</accession>
    <accession>C8V253</accession>
    <name>Q5AY66_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ANIA_06764</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF71413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_664368.1">
        <property type="nucleotide sequence ID" value="XM_659276.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AY66"/>
    <dbReference type="GeneID" id="2870290"/>
    <dbReference type="KEGG" id="ani:ANIA_06764"/>
    <dbReference type="eggNOG" id="ENOG502QS40">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029138_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AY66"/>
    <dbReference type="OMA" id="VRYINYS"/>
    <dbReference type="OrthoDB" id="2548233at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42034">
        <property type="entry name" value="CHROMOSOME 7, WHOLE GENOME SHOTGUN SEQUENCE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42034:SF1">
        <property type="entry name" value="CONDENSATION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF71413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="497" mass="55871" checksum="45821542B819F99E" modified="2005-04-26" version="1">MAVSADDRLEWKLTQPGLWERDIDEVEEFYASLAKAYERTGRVFFAMTGFISFSVPVQPGTALQKVEKRAEEALKSAWIRLRYNHPTIASRVLYDPAQRRYKKVYETIIDDASQHQWVDETFQVVSERMSGLDWCNADPPVPALPTLFLIRAPATDDRVFRADLVLRAHHDVIDGVGTLLLFHNLFTLAAEAYGQVSYELPQFGDEWLNLSPPLRRAAEIPDVLSPEHEEVLREILEYNSGVKGEVEIASPPFQRHIALPGKHQRVAITLSESNTARLLTKCRTLGLSITHAYHASIALTVGALTVGALQERKETERTLRYISYCLINERHHCKDPYSTSAHPASVYHSVSGRCLAIDLTGPALGAPSTTPKIEDIFLPIAEHVRDYYLEIRNNEEHIKLVPAYWAMSILPYPESEPPAIPPRNETPSASISSMGVLDKVIRHQYGSFSVENPWVTGEELGTGLGLFLAYNEAWHGREEVLDVLNRCNKIVLQGLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="110" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AYX3</accession>
    <accession>C8V0I6</accession>
    <name>Q5AYX3_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">snRNA cap binding complex subunit (Gcr3), putative (AFU_orthologue AFUA_6G05130)</fullName>
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    <gene>
        <name evidence="4" type="ORF">ANIA_06507</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF70876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_664111.1">
        <property type="nucleotide sequence ID" value="XM_659019.2"/>
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    <dbReference type="AlphaFoldDB" id="Q5AYX3"/>
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        <property type="interactions" value="876"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5AYX3"/>
    <dbReference type="GeneID" id="2870281"/>
    <dbReference type="KEGG" id="ani:ANIA_06507"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN6507"/>
    <dbReference type="eggNOG" id="KOG1104">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013816_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AYX3"/>
    <dbReference type="OMA" id="CAAEGLM"/>
    <dbReference type="OrthoDB" id="10252707at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005846">
        <property type="term" value="C:nuclear cap binding complex"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0005634">
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    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
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    </dbReference>
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        <property type="term" value="P:mRNA export from nucleus"/>
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    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000079">
        <property type="entry name" value="Related to cap binding protein 80 (Cbp80)"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="1.25.40.180:FF:000035">
        <property type="entry name" value="snRNA cap binding complex subunit (Gcr3)"/>
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    <dbReference type="FunFam" id="1.25.40.180:FF:000045">
        <property type="entry name" value="snRNA cap binding complex subunit (Gcr3), putative"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
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    <dbReference type="InterPro" id="IPR027159">
        <property type="entry name" value="CBP80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015172">
        <property type="entry name" value="MIF4G-like_typ-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015174">
        <property type="entry name" value="MIF4G-like_typ-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12412">
        <property type="entry name" value="CAP BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12412:SF2">
        <property type="entry name" value="NUCLEAR CAP-BINDING PROTEIN SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09088">
        <property type="entry name" value="MIF4G_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09090">
        <property type="entry name" value="MIF4G_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MIF4G-like type 1" evidence="2">
        <location>
            <begin position="323"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="MIF4G-like type 2" evidence="3">
        <location>
            <begin position="530"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="790"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="817"/>
            <end position="826"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBF70876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="834" mass="93073" checksum="6A794DA280726D04" modified="2005-04-26" version="1">MADYERRNHGPRGGGRKRRYRDDDDYDRRQRRRYEEPLVVKVRRQLLTIAESAARRAEDDALSIAKNVAENYEDEELRDNFIEVALDLVLEQPLKIPFIATTVLVANTIKSDLAADVLKHAVERFQHNVDAGAWREVKLLLRFLGCLQCILEGDGVFAILEELFSRAVDLQTASSEDLIGLELVKIILYTIPYIMASPVSGFESQALGLLEKTDIIASTPHTLVDLANPFGPDSQKSATVPSVISLLQSQLQAEASRNWELECLPRPWANVREGDEEPKRLEEGPKHVLPDITIPSPVLNGSRAIFPEVFLSVYGDQDIETVPSTSNIASSLLRDALVDTINIMDFNRIATAKFLIDLDCYFTPSIFVKRATPFDKLRDLPDDRTTWKPEDVAVDAVFSQLFQLPSPEHKLVYYHSVLTECCKIAPAAIAPSLGRAIRFLYRSLDVIDLELSHRFLDWFAHHLSNFGFTWKWSEWIEDLELPLVHPRMAFINGALDKEIRLSFAQRIRGTLPDPYQDLISEGKEKDTPDFKYASDTTPYANEGREIMQLIRRKAADDEIQPHITAIEERAAGLGVEIPLLPSTDAFVTSICFVGAKSLSHVLSCIERNKERLLAIGPRSPGARRQIITSVMEYWVDQPGIGINIIDKLLNYTILTPLSVIEWALVDHLDAGTILAKTHIFEMISATVGKVTNRLRQIVAARIQPGLYEPQLSVLDETLNREKKDMHALFQVIEDSVVSVAGGSNDQLMERGDGSGDLPEDEIIREWGKRWLRAFRRKAGVEEAFISQAMSSATPVGTKAPTPPPAAADGSVPGDGAGDGDMDIADADADRTAGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AZ56</accession>
    <accession>C8V0G4</accession>
    <name>Q5AZ56_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_06424</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF69500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_664028.1">
        <property type="nucleotide sequence ID" value="XM_658936.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AZ56"/>
    <dbReference type="STRING" id="227321.Q5AZ56"/>
    <dbReference type="GeneID" id="2871318"/>
    <dbReference type="KEGG" id="ani:ANIA_06424"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN6424"/>
    <dbReference type="eggNOG" id="KOG4176">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052246_1_0_1"/>
    <dbReference type="InParanoid" id="Q5AZ56"/>
    <dbReference type="OMA" id="PYKEFPE"/>
    <dbReference type="OrthoDB" id="271595at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032451">
        <property type="term" value="F:demethylase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070988">
        <property type="term" value="P:demethylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032857">
        <property type="entry name" value="ALKBH4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12463:SF1">
        <property type="entry name" value="2-OXOGLUTARATE AND FE-DEPENDENT OXYGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12463">
        <property type="entry name" value="OXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="2">
        <location>
            <begin position="90"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF69500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="218" mass="24834" checksum="9AA25FFE191364D9" modified="2005-04-26" version="1">MDTQASLPGFKEHPIVHGLYYQSDFITRDHEEQLITLFRTQLTWPDRPGRISVHYGYTFDYKTFGIDPDIPYKPFPDWLVPLLPKTESRPPDQVCLQYYPPGAGIPPHVDSHRGWDQLYALSIGAPVLMRLRHGKTGEERVDVDLEGRSMMCFSGPARLYWTHGIAKKKNDHMPDELLGIEKEKRSVLGAMVREAEKGLESEGRMTSPQKADDGDVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AZ61</accession>
    <accession>C8V0G9</accession>
    <name>Q5AZ61_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ANIA_06419</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF69509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_664023.1">
        <property type="nucleotide sequence ID" value="XM_658931.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AZ61"/>
    <dbReference type="GeneID" id="2871310"/>
    <dbReference type="KEGG" id="ani:ANIA_06419"/>
    <dbReference type="HOGENOM" id="CLU_028200_3_7_1"/>
    <dbReference type="InParanoid" id="Q5AZ61"/>
    <dbReference type="OMA" id="MIKECAC"/>
    <dbReference type="OrthoDB" id="4682787at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF164">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="69"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="104"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="183"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="227"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="88"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBF69509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="349" mass="38750" checksum="45DB81086F929A40" modified="2005-04-26" version="1">MRGAAGIKSGKEERSDQGQSATTRAKQRRKRHWSWLAAGLNDPPRSEPCPPGPARQRISVSMSVPDRGWVILAVSWPLFSICLVLVGLRVWVRTRIIKSWGWDDPFILLAFLCATMNSIFVTVSAHYGTGHHASDLSDYQRIESTKFNWLSQGFHVMSTNWGKVSVAIFLLRIIHKVKHHRPMMYGGIVLLTVVNTVAMIAAIVKTINLASLAARADYPWDTVDLTIWIAVEQYLIILAACIPTLTPLFNIAVRQRTSKKSTSNVNYKAGHHSGRSHPYDGLASGGIGKCEPDGYPLAWTRVERARAGSHSDSEDPIMATTESGRGILMTTEFHVQTGSENGDEHVERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AZ98</accession>
    <accession>C8V0Q4</accession>
    <name>Q5AZ98_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphatidylinositol-specific phospholipase C X domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_06382</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF69576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_663986.1">
        <property type="nucleotide sequence ID" value="XM_658894.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AZ98"/>
    <dbReference type="STRING" id="227321.Q5AZ98"/>
    <dbReference type="GeneID" id="2871280"/>
    <dbReference type="KEGG" id="ani:ANIA_06382"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN6382"/>
    <dbReference type="eggNOG" id="KOG4306">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_432868_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AZ98"/>
    <dbReference type="OMA" id="NNRCGNL"/>
    <dbReference type="OrthoDB" id="1046782at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08621">
        <property type="entry name" value="PI-PLCXDc_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051057">
        <property type="entry name" value="PI-PLC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593:SF143">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-SPECIFIC PHOSPHOLIPASE C X DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010186611" description="Phosphatidylinositol-specific phospholipase C X domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="630"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF69576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="630" mass="69092" checksum="ABBDB461E0EE0F14" modified="2005-04-26" version="1">MKFSQILTGLAGASSLCSALAASTSAPYGLNQGQKIRHNSATAAAAVCSADDATYSSESMPAGEYTDWGALGLDDVTSGRQYITIVNLTPHRFKLDSTHSYQMDMFDWGDIPPGRARQNIAHYSTRLTANPVDTGGEAYYSIVGTSKKFEIRATTHVPHMYWRRTVIDLSDMGLGQREYLDPRAEVPVTLVITGSDSYGFMASLTHGSGNWMKQMYRVIKDRPLQHLVMPGTHDSGMSTISGKIVSIGSEANTQTQGLNIYDQLRVGARWFDLRIMSVHQSDPSSYEFWVAHVNDETADVPVGNTGESLADIINEVNRFTSENPGEIIFLKLRYLIGIKRLPGGAIRWNTAIANKFFSELKKINNRCPNLDTTTKFQRQKASYFMDQNDGKGCVLFLLDGSNIPSGVPSSSPSDGIYPASAMTVNDHWSNLATTQPVAEDQIAVWSAINRVSPFTNDQFLISQWLVSADALQTTALTIQNIAIMPTNPALYWAGVNAMSPTKWPNVLLVDYIGVVITDQFAWNQLSAELYTLAIGLNLYMLSENCDVSGQRSPLLPPVAEASKTLAVKSALQKIAPSWNGIIFANGTIIDKPPRNLHYGRMELLKNGTVFGNGTVLEKDVPNPYLYSVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AZS5</accession>
    <accession>C8V1U9</accession>
    <name>Q5AZS5_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF1446 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_06205</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF69967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_663809.1">
        <property type="nucleotide sequence ID" value="XM_658717.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AZS5"/>
    <dbReference type="GeneID" id="2870782"/>
    <dbReference type="KEGG" id="ani:ANIA_06205"/>
    <dbReference type="eggNOG" id="ENOG502QS8D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012617_0_1_1"/>
    <dbReference type="InParanoid" id="Q5AZS5"/>
    <dbReference type="OMA" id="MVSAHAY"/>
    <dbReference type="OrthoDB" id="10265871at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056362">
        <property type="entry name" value="AtuA-like_ferredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010839">
        <property type="entry name" value="AtuA_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47585">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47585:SF1">
        <property type="entry name" value="DUF1446 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07287">
        <property type="entry name" value="AtuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23544">
        <property type="entry name" value="AtuA_ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyclic terpene utilisation N-terminal" evidence="1">
        <location>
            <begin position="10"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="AtuA-like ferredoxin-fold" evidence="2">
        <location>
            <begin position="526"/>
            <end position="646"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF69967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="654" mass="72087" checksum="0D9A0DC429748EF0" modified="2005-04-26" version="1">MSNKRAKRPVRVANCSGYHGDPAYEMYRQATLGDVDFITGDYLAGMWIMDDSSISSSLTRAWRAGKHPGYEETAWKGIQQTIDVIAEKGIKVVINGGALDPKALALKVQGLVRERNLNLRVAYLSGDDVYDRVGPNMPTTKEELQHLDSGNSSAAPAALTYAFLRGTADGKPIPMVSAHAYLGARGIVHGLRNGADIILCGRVADASPVIAAAWFWHDWAETDYDELAGALIAGHLIECSAYVTGGNFSGFDRYNLDDLIEPGFPIAEIDADGACIITKHPGTKGMVTVDTVRCQFLYELQGTVYLNSDVNAYIGDVAVEEVEKDRHDLLLSFQDLTKLIMVHSIRVSGIKGTAPPPTTKLAIFYQGGYEAEILLNATGYATSKKWDLLEKQIRYFLPDSVQKELETLEFQRIGTPSSNPISQASSTTYLRIFIASRSPHAHLTLTLDMRTAVPRPFLAYYPALIAQADLGERINLLNDDNTITSIETGHPPAYAPLQPRENYHPPSISPESPEYKTIFDGLTKRVKLGDVVLARSGDKGGNLNVGFFVPSSPPSPFTLETDKQRKQRERQKHLSLWLRHYLTTSRMRDLLGTDWRDDYFIERVEFPAIGAVHFVIYGILGRGVSSSSRLDGLGKGVADWLRDVVVEVPVALLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AZZ6</accession>
    <accession>C8V2C1</accession>
    <name>Q5AZZ6_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_06134</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF70112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_663738.1">
        <property type="nucleotide sequence ID" value="XM_658646.1"/>
    </dbReference>
    <dbReference type="GeneID" id="2871212"/>
    <dbReference type="KEGG" id="ani:ANIA_06134"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN6134"/>
    <dbReference type="eggNOG" id="ENOG502SNNS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_240288_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AZZ6"/>
    <dbReference type="OMA" id="MACINSA"/>
    <dbReference type="OrthoDB" id="3886018at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052504">
        <property type="entry name" value="Mucin_signaling_protection"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24041">
        <property type="entry name" value="MUCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24041:SF30">
        <property type="entry name" value="MUCIN-3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010179228" evidence="2">
        <location>
            <begin position="22"/>
            <end position="1720"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="491"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="696"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1366"/>
            <end position="1387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1551"/>
            <end position="1578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="181"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="206"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="268"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="514"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="539"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="555"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="697"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1366"/>
            <end position="1376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1562"/>
            <end position="1575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF70112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="1720" mass="185115" checksum="3703D56026B0F72B" modified="2005-04-26" version="1">MWLPMLWYACSLIASAAHAVAQVISPDNAAAESVSASTVITSYVLSPVLITSYVPTSERSDGWAGFSPSLTFPASTGGVSTSLSSSIVLIPSVSNSLGPSSSVAVSLGPNLLVSTLSVMGPVVPSSLGFPGSSILVSSSSESILSESSPSIPRTSTVAISIPSASIVPSTSSNAVPSTEGSSSSSTNAVPSTSTGEISSANTLVIPSGSSSVTPSNSPGVISSTSTSNAPGSGAVFSSNTSTALIPTSTPSVTLSPVDPSVTLATGISTSTTSVPDSTSSSSVTSTTRVPQSPPTDVRTSTTLVVTVTEEPHITVANPVTITTADDAGPTVVDFPITTNDRSRDPLITAAPVSETTIAPPLPRTVLASSMSGISDDFASVLPIIDAWVEKPSPSLQTQAVKGIDGVEDDIEHFIKVLGGELPPSCDSLRKRGLIDGALNIAKDIAGAAGDVAGKLLRQLGCIGKITSHLKDAIEKQDIDGVKKMMHDLIAPENIADTPVLDPTSKPPGPDNNDDDNHNEDRNEHHSNDDFGDKDNGNNAEDDSDDTDDESDEDNGNSSTSTSQTTTTTSCTSEGTVYHVTVLCEPTPVTFGDSTTSTTACYPTTTITTSGCSVTATTTTVTSTPTSLELCMPGTCGSACSYGHGGWMTLSTLDCVKVPTVAVSALPTESQISHRRVPPVIPPAIHRRAFSFVKRDDDNDFIDEDGPNDDVEPVDYDDDEPMDNNDFFDDDEPLAEQVPSDLPAIGEMQHEDLYRVYKFLTANDKWTVVMDDTAVSGEWWPYEPYGEKPARIAIGMPGLYGCTAIFIVSNKGVYTAHFWEWPVFWSDQQGLQETTDEHFKKYTVDALLQGGNEFPDVQITLPDLMGTDERPGPLHPFNLPKVYVITPWSEEGSALVQYPERTHWLGSQITAFLYQIYEGEVPDGANYEVYGYLRTSKYSIYSDDDHIGKVLLDASPYYRFDVPDLQRYHRVGRYRLWVMGVSVKDALFYAEWNSLRPTIDQVQRRDVPLDNHRLCPIPIPSLTSSPIPTPAPTQLCEPGDCGDVCSAGGGAWVTLSPVDCGNIPTTTVTALPTESQTYNSVIDLSIRRREYELLRREDDNVKPLPNTQQEHLIDIYRRLTSETAWFNFPRVSTAGMWFAFPEKASTVLGIKGLYGCTSVIIVSSKGVYISHIWEKPTFINRDEEGRIYETDEEYFKKYSFDALTQGGEEFDNVEPISSLVGTLANPGPLHPKNTPRVFVVTHTTEDGKRLEYEYRVSLLAELFTAFLYQSSAWGIPQGADGQTVGYQPGPRDLAEGDNAHWGKVILEVSPIDHVLQAGNQHVAVGRYRLWVSGTRVDDTEFWTFPHVPAQVQQRDVSYNEVCPMITSSSTASPNPSTFITTTSVRPVNPPGQPPGFTLPTYVPPKPTNNAEGTLSANMDLVSERICFEEDDFVPAKLDQANVEDVAELCRDGQGPINDNTMLGPDDERIEYSLASGNSPHEEPWYVVDVEWVKGCEGPAQNVHHPMVGRNCHQLIVDNFSMKNCKTKYGYGGSIVIGCLRYTSQLRGGGIKGVQVSRPEDLDSSGSSSSTESGAAEPLPSAKSLVKETVCLLDSDPINIKNDSLVDELIEKCEGDGISKHDMSLGPSDKIEWIVGGLPKSTEIYYSIVSWEKGCEGPNQNPVTPMVGLTCKDITKKHFELGCIRPGNVGVGGTTVVGCLRYQSYMGGYPLGELHEGAMPEA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2024-03-27" modified="2025-02-05" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B027</accession>
    <accession>C8V2K2</accession>
    <name>AASB_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Lytic polysaccharide monooxygenase aasB</fullName>
            <shortName evidence="6">LPMO aasB</shortName>
            <ecNumber evidence="8">1.14.99.55</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">aasB</name>
        <name type="ORF">AN6103</name>
        <name type="ORF">ANIA_06103</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2020" name="Biotechnol. Biofuels" volume="13" first="135" last="135">
            <title>Loss of AA13 LPMOs impairs degradation of resistant starch and reduces the growth of Aspergillus nidulans.</title>
            <authorList>
                <person name="Haddad Momeni M."/>
                <person name="Leth M.L."/>
                <person name="Sternberg C."/>
                <person name="Schoof E."/>
                <person name="Nielsen M.W."/>
                <person name="Holck J."/>
                <person name="Workman C.T."/>
                <person name="Hoof J.B."/>
                <person name="Abou Hachem M."/>
            </authorList>
            <dbReference type="PubMed" id="32774456"/>
            <dbReference type="DOI" id="10.1186/s13068-020-01775-z"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Lytic polysaccharide monooxygenase involved in breakdown of granular resistant starch.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>starch + reduced acceptor + O2 = D-glucono-1,5-lactone-terminated malto-oligosaccharides + short-chain malto-oligosaccharides + acceptor + H2O.</text>
            <dbReference type="EC" id="1.14.99.55"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
        <text evidence="2">Binds 1 copper ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="5">Impairs degradation of resistant potato starch, but has limited impact on less-resistant wheat starch and no impact on processed solubilized starch.</text>
    </comment>
    <comment type="biotechnology">
        <text evidence="2">Starch-active PMOs provide an expanded perspective on studies of starch metabolism and may have potential in the food and starch-based biofuel industries.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the polysaccharide monooxygenase AA13 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.55" evidence="8"/>
    <dbReference type="EMBL" id="AACD01000104">
        <property type="protein sequence ID" value="EAA58078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF70179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_663707.1">
        <property type="nucleotide sequence ID" value="XM_658615.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B027"/>
    <dbReference type="SMR" id="Q5B027"/>
    <dbReference type="EnsemblFungi" id="CBF70179">
        <property type="protein sequence ID" value="CBF70179"/>
        <property type="gene ID" value="ANIA_06103"/>
    </dbReference>
    <dbReference type="GeneID" id="2870778"/>
    <dbReference type="KEGG" id="ani:ANIA_06103"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN6103"/>
    <dbReference type="eggNOG" id="ENOG502QSJT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073361_0_0_1"/>
    <dbReference type="InParanoid" id="Q5B027"/>
    <dbReference type="OMA" id="CPECTIV"/>
    <dbReference type="OrthoDB" id="550577at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004302">
        <property type="entry name" value="Cellulose/chitin-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052282">
        <property type="entry name" value="Starch-active_LPMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36575">
        <property type="entry name" value="BINDING PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G14430)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36575:SF2">
        <property type="entry name" value="CHITIN-BINDING TYPE-4 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03067">
        <property type="entry name" value="LPMO_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword id="KW-0186">Copper</keyword>
    <keyword id="KW-1015">Disulfide bond</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-0624">Polysaccharide degradation</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010538789" description="Lytic polysaccharide monooxygenase aasB" evidence="3">
        <location>
            <begin position="19"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </ligand>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="4">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="4">
        <location>
            <position position="306"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="40"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="66"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="102"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="118"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="153"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="167"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="181"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="Q2U8Y3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="Q7SCE9"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3"/>
    <evidence type="ECO:0000255" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="32774456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="6">
        <source>
            <dbReference type="PubMed" id="32774456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="7"/>
    <evidence type="ECO:0000305" key="8">
        <source>
            <dbReference type="PubMed" id="32774456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBF70179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="328" mass="36354" checksum="92019C47076C6234" modified="2005-04-26" version="1" precursor="true">MKAFFAISASTLLATVHGHGYLTVPASRTRLGFEAGIDTCPECSILEPVDAWPNVTEAQVGRSGPCGYNARVSVDYNQPGDNWGNEPVVTYKAGDIVEVQWCVDNNGDHGGMFTYGICQDQELVDKFLDPDYLPTEEEKQAAEDCFLQGELKCGDVDGQECEYSPDCGEGEACYRNDWFTCNAFEADSDRGCQGVDGAELNSCKTTIAGGYTVTKKIKIPDYTSEHTLLRFRWNSFQTPQIYLHCADPTIEGGMEVRMRMIVMHGSFGVDTQHSFGHSFGFQGEGVYRAYRYIRGVAIIQMNLNINASLLPQPTLPIRGWSTRNIQHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B0G8</accession>
    <accession>C8V3D9</accession>
    <name>Q5B0G8_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_05962</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF70475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_663566.1">
        <property type="nucleotide sequence ID" value="XM_658474.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B0G8"/>
    <dbReference type="STRING" id="227321.Q5B0G8"/>
    <dbReference type="GeneID" id="2870895"/>
    <dbReference type="KEGG" id="ani:ANIA_05962"/>
    <dbReference type="eggNOG" id="KOG0118">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043434_0_0_1"/>
    <dbReference type="InParanoid" id="Q5B0G8"/>
    <dbReference type="OMA" id="MRIGFYP"/>
    <dbReference type="OrthoDB" id="2935572at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd12261">
        <property type="entry name" value="RRM1_3_MRN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="99"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF70475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="340" mass="37529" checksum="6B5CB1D851DCE53B" modified="2005-04-26" version="1">MSSSVVSGTVSPGCLSQSLKRRVISIILYGTPPFPSEAHENGEESVRNKVPLSNGYSEPFSAEPDHSHHNIPTELCDGGDNDEDALTDSHSDERDDYGESSGSASSSPQAEQRTILICGLPDKATHRNIVDVVRGGAILHIYVWARDHTASVSFVEESAAQDFLDHTRRYGLYVAEKRVDVLWNDRQFYLPPFVRSKICSGASRNLVIYNVNPNITEGLIRRDMEHIHNLIVISVKFRHGNAYISTNSVHNALFARSCLMSRLTYKGMKIGFYPDECAEPLTRIPAGPRRDAPASKRPASLPNRFHLLSIDVSEDEESEEHALGVSLNGGVCWPDNSVSA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-11-22" modified="2026-01-28" version="123" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B0V6</accession>
    <accession>C8V079</accession>
    <name>AKR1_EMENI</name>
    <protein>
        <recommendedName>
            <fullName>Palmitoyltransferase akr1</fullName>
            <ecNumber>2.3.1.225</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Ankyrin repeat-containing protein akr1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">akr1</name>
        <name type="ORF">AN5824</name>
    </gene>
    <organism>
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Palmitoyltransferase specific for casein kinase 1.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location>Early endosome membrane</location>
            <topology>Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DHHC palmitoyltransferase family. AKR/ZDHHC17 subfamily.</text>
    </comment>
    <comment type="sequence caution" evidence="5">
        <conflict type="erroneous gene model prediction">
            <sequence resource="EMBL-CDS" id="EAA58333" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EC" id="2.3.1.225"/>
    <dbReference type="EMBL" id="AACD01000100">
        <property type="protein sequence ID" value="EAA58333.1"/>
        <property type="status" value="ALT_SEQ"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF70774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B0V6"/>
    <dbReference type="SMR" id="Q5B0V6"/>
    <dbReference type="FunCoup" id="Q5B0V6">
        <property type="interactions" value="606"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5B0V6"/>
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        <property type="protein sequence ID" value="CBF70774"/>
        <property type="gene ID" value="ANIA_05824"/>
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    <dbReference type="VEuPathDB" id="FungiDB:AN5824"/>
    <dbReference type="eggNOG" id="KOG0509">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012510_1_0_1"/>
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    <dbReference type="OMA" id="FWVGFRY"/>
    <dbReference type="OrthoDB" id="6781668at2759"/>
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        <property type="component" value="Chromosome I"/>
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        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="C:Golgi membrane"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Ankyrin_rpt"/>
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        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161:SF85">
        <property type="entry name" value="PALMITOYLTRANSFERASE HIP14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
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    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0012">Acyltransferase</keyword>
    <keyword id="KW-0040">ANK repeat</keyword>
    <keyword id="KW-0967">Endosome</keyword>
    <keyword id="KW-0333">Golgi apparatus</keyword>
    <keyword id="KW-0449">Lipoprotein</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0564">Palmitate</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000212923" description="Palmitoyltransferase akr1">
        <location>
            <begin position="1"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="2">
        <location>
            <begin position="1"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="315"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="336"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="2">
        <location>
            <begin position="357"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="373"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="2">
        <location>
            <begin position="394"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="403"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="2">
        <location>
            <begin position="424"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="501"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="2">
        <location>
            <begin position="522"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="550"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="2">
        <location>
            <begin position="571"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK 1">
        <location>
            <begin position="97"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK 2">
        <location>
            <begin position="131"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK 3">
        <location>
            <begin position="164"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK 4">
        <location>
            <begin position="197"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK 5">
        <location>
            <begin position="230"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="DHHC" evidence="3">
        <location>
            <begin position="456"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="7"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="active site" description="S-palmitoyl cysteine intermediate" evidence="1">
        <location>
            <position position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <sequence length="737" mass="81453" checksum="7A7122A262C9E38A" modified="2005-11-22" version="2">MSSGDPPSGLQASGSNSSAALGLSPPSAPSGKSAATPPKVATDDASVELSSMKSERSPAKSIPLGEDIMQVARIGEVSVMQKLFDEKKFTANYSDEEGITPLHWAAINNQYAMCKFLIDSGADVNAKGGESVATPAMWAAQRCHYYIVHLLLQYGADPLLTDVQGYNILHLATIDGNAFLLVLLLHQEIPVDVVDQQGHTGLMWAAYKGYPACVDLFLRWGANPNAVDDGGLAPLHWALVKGSLPCVLKILEYGADRFATTTDGKTPALVAQEMNTRHVWYRALSECGYDADGNRKVLPMGLGPYVRDKAIMSKFFFFWPFLLLFVVLWILSNMVVYFAIPVAAVAVFGLQWVAKKAASQGPSEFRIIQKTPFLAGVFAGSLFWVFVRYVLYVLPATYSTNPFLNLGFVVFFSLTTYFYFYSMVADPGYVPKLGSRNEQRAVIGQLFEEWKFDEENFCVYCMIRRPLRSKHCRRCSRCVAKHDHHCPWIDNCVGVNNLRQFVLYILCLEIGIILFLHLTFNYINGLPAPAEPICNILNDQICSFVLRDTFTLLLDVWIAIQLVWVTMLGVVQLVQVSRNQTTYENMRGHSLDRGHSSTRAFASAVTAGTTSLDAAGLSASGQGPNPALAQGGHRHRGGCLKQWSSLLGFDTFFATARDGLRDGPRAARPRNPFSRGIVTNCRDFWCDPAPYFGKREPGSAMLGGEIVNYNRMYETPSRMYSSGDYRSVAYDEAADIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="104" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B1I3</accession>
    <accession>C8VG08</accession>
    <name>Q5B1I3_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome b-c1 complex subunit 6, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Complex III subunit 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">ANIA_05597</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UQCRH/QCR6 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF81592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_663201.1">
        <property type="nucleotide sequence ID" value="XM_658109.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B1I3"/>
    <dbReference type="STRING" id="227321.Q5B1I3"/>
    <dbReference type="GeneID" id="2871887"/>
    <dbReference type="KEGG" id="ani:ANIA_05597"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN5597"/>
    <dbReference type="eggNOG" id="KOG4763">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115913_0_0_1"/>
    <dbReference type="InParanoid" id="Q5B1I3"/>
    <dbReference type="OMA" id="NEDCVEE"/>
    <dbReference type="OrthoDB" id="405848at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045275">
        <property type="term" value="C:respiratory chain complex III"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.20:FF:000003">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.20">
        <property type="entry name" value="Ubiquinol-cytochrome C reductase hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003422">
        <property type="entry name" value="Cyt_b-c1_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023184">
        <property type="entry name" value="Ubol_cytC_Rdtase_hinge_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036811">
        <property type="entry name" value="Ubol_cytC_Rdtase_hinge_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15336:SF0">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 6, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15336">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX 7.8 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02320">
        <property type="entry name" value="UCR_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81531">
        <property type="entry name" value="Non-heme 11 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Ubiquinol-cytochrome C reductase hinge" evidence="12">
        <location>
            <begin position="93"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="13"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="53"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CBF81592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="162" mass="18147" checksum="3B03B9AA6781F171" modified="2005-04-26" version="1">MGLTDFFSDVISSLGFPEAYAEAPAETTEESSAPEEVKDDASAEESTEKSEDSAAEDTPEESSEEEEKGEEPEAEAEEEEEEEEEEEEEEPEDVKPKLEEECANSPQCAPYKHHYDECVERVTAQQEDADYKGPKEDCVEEFFHLAHCATQCAAPKLWKALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="127" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B1Y3</accession>
    <accession>C8VGH3</accession>
    <name>Q5B1Y3_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Glutamate decarboxylase</fullName>
            <ecNumber evidence="3 9">4.1.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ANIA_05447</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 9">
            <text>L-glutamate + H(+) = 4-aminobutanoate + CO2</text>
            <dbReference type="Rhea" id="RHEA:17785"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:59888"/>
            <dbReference type="EC" id="4.1.1.15"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the group II decarboxylase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.15" evidence="3 9"/>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF81894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_663051.1">
        <property type="nucleotide sequence ID" value="XM_657959.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B1Y3"/>
    <dbReference type="FunCoup" id="Q5B1Y3">
        <property type="interactions" value="304"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5B1Y3"/>
    <dbReference type="GeneID" id="2871735"/>
    <dbReference type="KEGG" id="ani:ANIA_05447"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN5447"/>
    <dbReference type="eggNOG" id="KOG1383">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019582_2_2_1"/>
    <dbReference type="InParanoid" id="Q5B1Y3"/>
    <dbReference type="OMA" id="ECRDKNM"/>
    <dbReference type="OrthoDB" id="5152799at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004351">
        <property type="term" value="F:glutamate decarboxylase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006538">
        <property type="term" value="P:L-glutamate catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000017">
        <property type="entry name" value="Glutamate decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.160:FF:000004">
        <property type="entry name" value="Glutamate decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.50:FF:000001">
        <property type="entry name" value="Glutamate decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010107">
        <property type="entry name" value="Glutamate_decarboxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01788">
        <property type="entry name" value="Glu-decarb-GAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43321">
        <property type="entry name" value="GLUTAMATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43321:SF6">
        <property type="entry name" value="GLUTAMATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="5 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="480"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="480"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7">
        <location>
            <position position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CBF81894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="515" mass="58898" checksum="6638DB0638482AC7" modified="2005-04-26" version="1">MVHLASIKKDDDFEPVVNRVDSIKLDTIEEDDYSATVYGTRFATQQLPHAEMPDREMPREVAYRMIKDELSLDGNPMLNLASFVTTYMEDEAEKLMAESFSKNFIDYEEYPQSAEIQNRCVNMIARLFNAPTDSDTDHPMGTSTVGSSEAIMLGTLAMKKRWQNKRKAEGKDYSRPNIVMNSAVQVCWEKAARYFDVEERYVYCTEERYVIDPQQAVDLVDENTIGICAILGTTYTGEYEDVKAINDLLVERGLDCPIHVDAASGGFVAPFIHPTLQWDFRLEKVVSINVSGHKYGLVYPGVGWVVWRSPEFLPKELIFNINYLGAEQASFTLNFSKGASHVIGQYYQMIRLGKRGYRSVMVNITRIADYLADQLEQLGFIIMSQRRGRGLPLVAFRLPADRADETFDEFAIAHQLRERGWIVPAYTMAPHSNNLKLMRVVVREDFSMSRCDQLLSDIKLALKSLREMDQAMLERYTQHVRSHTTKSHRAKHTHPHYKNETHSLQGRTGKTHGVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B246</accession>
    <accession>C8VGP1</accession>
    <name>Q5B246_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dienelactone hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_05384</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF82000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_662988.1">
        <property type="nucleotide sequence ID" value="XM_657896.1"/>
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    <dbReference type="AlphaFoldDB" id="Q5B246"/>
    <dbReference type="ESTHER" id="emeni-q5b246">
        <property type="family name" value="Dienelactone_hydrolase"/>
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    <dbReference type="GeneID" id="2871676"/>
    <dbReference type="KEGG" id="ani:ANIA_05384"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN5384"/>
    <dbReference type="eggNOG" id="KOG3043">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054590_2_3_1"/>
    <dbReference type="InParanoid" id="Q5B246"/>
    <dbReference type="OMA" id="VWIMAHS"/>
    <dbReference type="OrthoDB" id="17560at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630">
        <property type="entry name" value="DIENELACTONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630:SF87">
        <property type="entry name" value="DIENELACTONE HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dienelactone hydrolase" evidence="1">
        <location>
            <begin position="30"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF82000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="282" mass="31359" checksum="2F880DD37C80752C" modified="2005-04-26" version="1">MASDSCTECIKGSIHAGLPAGTKETIHGLNTYLTGNRTTPYAIVVMYSDVFGLSLPNNKLIADAYAKSGEWLDYLPDFFKGDRVPLSMAEHLIPVDATKQSVFRKYTGLLASIPSFFNWQNRHRQGPTDAICMEFLRALRRERKGMKIGMVGFCWVGEYAIGAGLEENMIDIDGARVPLVDALVALHPSHLAIPDDDKTLVVPVSLGWRAEDSLVDFKQMNMVKGVHADNKASGREVPGIAHHEYKPGRHGFAVRGNPDDPQERKYLEDSVTQVLTWFGRWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B305</accession>
    <accession>C8V804</accession>
    <name>Q5B305_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ANIA_05075</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF76143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_662679.1">
        <property type="nucleotide sequence ID" value="XM_657587.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B305"/>
    <dbReference type="STRING" id="227321.Q5B305"/>
    <dbReference type="GeneID" id="2872872"/>
    <dbReference type="KEGG" id="ani:ANIA_05075"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN5075"/>
    <dbReference type="eggNOG" id="ENOG502SJQV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_354122_0_0_1"/>
    <dbReference type="InParanoid" id="Q5B305"/>
    <dbReference type="OMA" id="LEEAIWI"/>
    <dbReference type="OrthoDB" id="5422579at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF76143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="793" mass="90006" checksum="A82D745B4E1E45C2" modified="2005-04-26" version="1">MKREEDGLDKPCLFKWSPSDLILCLCSANSREMKEALVAELQGPAPCYEPDFPGLFPVHSMDLIELWLAAKTTLYSTLLDRYGPLLDVGSQYKILPRFQFTTLSPYWQPQNQNQNQNRPRPALIELSARVSGAPVLTVMLETKVTYHSVLGNATAGPMMFYTGAAIHWTMLGFFVAEPSNRLGEVWSNAFFQQQGLMVRLFSYEYDSVDTFSTGFGRVSGEADGLLNHISTVRPKAALVNASQNGHYAEIKSATNLDSQISRFTLPPPYKEGDVCRAKLTRVRMNALPTEIIAIIAGYLPNSGIKTLRLTCRTLCNTVRLRLDRVFLSANPLNIAVFRAIADSETFRHGIKEIIWDDARFLQVPYGEFHIADSREDLRIDKESGCLQWFVDACKKNREDLQMRKFAHLDRGKMPKQIVVAEEQAATELPLWICWQYYQNLLQQQEEVIVFNKDAQALEYGLRRFPALKRVTVTPAAHGWIFTPLYETPMIRAFPRGFNYPIPRGWPSVSSSGTYRPRAQPWEDEATKKDYRGFGIITRALASYTKHQVSELIIDAHALDTGLNCRVFEEPNPEYDDLVTILRRPGFTRLDLSLSVRGQEWTGWPCFRNGYLRRALAEAHDLKHIALSTDVEEDPASDTTVPETGGGRAQLVSLRTILPTEKWHSLRYFSLSNFLVDKNDIIAILSSLPPTLRFVHIGFLYFVDHGGSYRELLEDMRDQLDWRSRDPTIRPVVSVAKPTMYIQIGHAIWLDGEVSQFLYGDGPNPFYNGGDAVGEVGVVRDAFMDGVEWRNRGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B3S4</accession>
    <accession>C8VAL1</accession>
    <name>Q5B3S4_EMENI</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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    </protein>
    <gene>
        <name evidence="1" type="ORF">ANIA_04806</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF76743.1"/>
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        <property type="component" value="Chromosome III"/>
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        <property type="entry name" value="DOPA-like domains"/>
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        <property type="entry name" value="DOPA_dioxygen"/>
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        <property type="entry name" value="DOPA-like"/>
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        <source>
            <dbReference type="EMBL" id="CBF76743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="188" mass="22233" checksum="877FC703BA9957EF" modified="2005-04-26" version="1">MTDQFAYTYPSPLVGYENLEPLPEERNDDGKSLKNPQHGILSKAYEEFPDPLSKGRRGGFDIHIYHFQNNPDQVAYARALWERIRREFPELRIYTFWDKPVGPHPVAMFEVNLFTPAQFGAFIPWLVIYRGPLSVLVHPNTEAHEDERNHTQRAMWLGDRIPLDLRVFKIMKEKERVEREKNENKEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B3Z8</accession>
    <accession>C8VAU3</accession>
    <name>Q5B3Z8_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UBL3-like ubiquitin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_04732</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF76904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_662336.1">
        <property type="nucleotide sequence ID" value="XM_657244.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B3Z8"/>
    <dbReference type="STRING" id="227321.Q5B3Z8"/>
    <dbReference type="GeneID" id="2872533"/>
    <dbReference type="KEGG" id="ani:ANIA_04732"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN4732"/>
    <dbReference type="eggNOG" id="ENOG502S95Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055856_0_0_1"/>
    <dbReference type="InParanoid" id="Q5B3Z8"/>
    <dbReference type="OMA" id="HPNVVHM"/>
    <dbReference type="OrthoDB" id="1043111at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040015">
        <property type="entry name" value="UBL3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039540">
        <property type="entry name" value="UBL3-like_ubiquitin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13169:SF0">
        <property type="entry name" value="UBIQUITIN-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13169">
        <property type="entry name" value="UBIQUITIN-LIKE PROTEIN 3 HCG-1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13881">
        <property type="entry name" value="Rad60-SLD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBL3-like ubiquitin" evidence="2">
        <location>
            <begin position="147"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF76904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="253" mass="27400" checksum="8B9088751ED2CD71" modified="2005-04-26" version="1">MASNDRTQLDGPDHAINTGDSISAAPDSSQPVSSSTIDVSESANKTSLPAEAPKDNMAADLSNTGTADNGNAALAPSDQTNSEAIVPTSASPETEEQKVATPAPELSSDASVKEPEQSGPSLTIVLLLITGTRYPFKIDANYLRKRDISVDNYDPFSMSVYTLKELIWRAWQDDWEPRPSSPSSIRLISFGKLLDDKSPLSDSKFSRDAPNVVHMTVKPQEIVDEEDAKGGKAQYSRDREASERSPRCRCVIQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-11-22" modified="2026-01-28" version="101" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B433</accession>
    <accession>C8VAY0</accession>
    <name>PFA5_EMENI</name>
    <protein>
        <recommendedName>
            <fullName>Palmitoyltransferase pfa5</fullName>
            <ecNumber>2.3.1.225</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Protein fatty acyltransferase 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">pfa5</name>
        <name type="ORF">AN4697</name>
    </gene>
    <organism>
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction>
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="PTM">
        <text evidence="1">Autopalmitoylated.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DHHC palmitoyltransferase family. PFA5 subfamily.</text>
    </comment>
    <comment type="sequence caution" evidence="5">
        <conflict type="erroneous gene model prediction">
            <sequence resource="EMBL-CDS" id="EAA60739" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EC" id="2.3.1.225"/>
    <dbReference type="EMBL" id="AACD01000080">
        <property type="protein sequence ID" value="EAA60739.1"/>
        <property type="status" value="ALT_SEQ"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF76977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B433"/>
    <dbReference type="FunCoup" id="Q5B433">
        <property type="interactions" value="895"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5B433"/>
    <dbReference type="EnsemblFungi" id="CBF76977">
        <property type="protein sequence ID" value="CBF76977"/>
        <property type="gene ID" value="ANIA_04697"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AN4697"/>
    <dbReference type="eggNOG" id="KOG1315">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034009_0_0_1"/>
    <dbReference type="InParanoid" id="Q5B433"/>
    <dbReference type="OMA" id="SFYTKDV"/>
    <dbReference type="OrthoDB" id="331948at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883:SF23">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883">
        <property type="entry name" value="ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0012">Acyltransferase</keyword>
    <keyword id="KW-0449">Lipoprotein</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0564">Palmitate</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000212978" description="Palmitoyltransferase pfa5">
        <location>
            <begin position="1"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="DHHC" evidence="3">
        <location>
            <begin position="172"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="94"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="326"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="433"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="447"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="460"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <sequence length="486" mass="54292" checksum="DB22AF3017393296" modified="2011-11-16" version="2">MAGQPDRRINLAVARVIPVVLFGIIIYSCYVITKPLCIDYLIDPLPKYNRPSRVGAGAAILVVFYILLLFVIITYVRLLYTVVYNPDLLPRSQAADQQSTPAKRSKSRSRRKGHGHGHRKSKSDEVSDKPVSDVERALDYNAGPMVLPWDTAGLEYFYKKDVFVCQPDGRPIYCSKCCHYKPDRTHHCREVDRCVRKMDHFCPWVGGVVSETSFKFFIQFVFYTALFCMTVLIVCAIYTAELRQDVSLISGSRNMLIISRLVMLTLIGLSDSLQLAAFNLTTIENLNRRSAVWTLAIRVPNHMISRIQPGTRWAPTFRTITYPLPPVPPPLSGMPTQPATGEGDNPYSPPPVPSTDPSAEQHIFAILQTLPGENPFALGSPLKNLQQVLGHSIIDWLLPIKRSPCADHSSAESEFVMGPVVSRLKKEAGLESKDAAAGSITTKHKNSSYNSSPSAPADKRSKRKQKRGKHHHHHHHHRHSSTTGTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B483</accession>
    <accession>C8V7N7</accession>
    <name>Q5B483_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Phytanoyl-CoA dioxygenase family protein (AFU_orthologue AFUA_2G01850)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ANIA_04647</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PhyH family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF77073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_662251.1">
        <property type="nucleotide sequence ID" value="XM_657159.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B483"/>
    <dbReference type="STRING" id="227321.Q5B483"/>
    <dbReference type="GeneID" id="2872445"/>
    <dbReference type="KEGG" id="ani:ANIA_04647"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN4647"/>
    <dbReference type="eggNOG" id="KOG3290">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048953_0_1_1"/>
    <dbReference type="InParanoid" id="Q5B483"/>
    <dbReference type="OMA" id="KYSEDNW"/>
    <dbReference type="OrthoDB" id="445007at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE DOMAIN CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883:SF15">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBF77073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="313" mass="34678" checksum="1F2567593E4FF73F" modified="2005-04-26" version="1">MPGLTPAQVTSFHENGYLVLPDYLTPQQINALITETTSLLTSFDLSTHPLTQFTTGDDEKDNKPHVGDDYFLTSGDKIRFFFEPDAFTPDPSNPTKSILSRPKEKAINKIGHALHSLSKPFEAVSLNEQNAEIARSLGFRDPRVLQSMVICKQPGIGGAVPPHKDSEFLYTSPPSAVGFWFALQDAGVGNATLAMYKGSHKKRSGEVQRRFVRKYNEAGQLCGTGFVSNEGEKFPRDLEVGEDEGEPEVEVLDVKAGSLVLIHGNVLHKSEKNTGDKSRFAYTFHVIEGAEGWEYDSRNWLQPPEGGFSRLYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="115" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B4M9</accession>
    <accession>C8V8D2</accession>
    <name>Q5B4M9_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">14-3-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ANIA_04501</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the 14-3-3 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF77379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_662105.1">
        <property type="nucleotide sequence ID" value="XM_657013.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B4M9"/>
    <dbReference type="SMR" id="Q5B4M9"/>
    <dbReference type="FunCoup" id="Q5B4M9">
        <property type="interactions" value="1374"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5B4M9"/>
    <dbReference type="GeneID" id="2872302"/>
    <dbReference type="KEGG" id="ani:ANIA_04501"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN4501"/>
    <dbReference type="eggNOG" id="KOG0841">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058290_0_0_1"/>
    <dbReference type="InParanoid" id="Q5B4M9"/>
    <dbReference type="OMA" id="KGCQLAR"/>
    <dbReference type="OrthoDB" id="10260625at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009847">
        <property type="term" value="P:spore germination"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="CDD" id="cd11309">
        <property type="entry name" value="14-3-3_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.190.20:FF:000002">
        <property type="entry name" value="14-3-3 protein epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.190.20">
        <property type="entry name" value="14-3-3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000308">
        <property type="entry name" value="14-3-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023409">
        <property type="entry name" value="14-3-3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036815">
        <property type="entry name" value="14-3-3_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023410">
        <property type="entry name" value="14-3-3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18860">
        <property type="entry name" value="14-3-3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00244">
        <property type="entry name" value="14-3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000868">
        <property type="entry name" value="14-3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00305">
        <property type="entry name" value="1433ZETA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00101">
        <property type="entry name" value="14_3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48445">
        <property type="entry name" value="14-3-3 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00796">
        <property type="entry name" value="1433_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00797">
        <property type="entry name" value="1433_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="14-3-3" evidence="5">
        <location>
            <begin position="3"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="233"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="243"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with phosphoserine on interacting protein" evidence="2">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with phosphoserine on interacting protein" evidence="2">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000868-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBF77379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="261" mass="29116" checksum="909367114559EB09" modified="2005-04-26" version="1">MGHEDAVYLAKLAEQAERYEEMVENMKVVAASDVELTVEERNLLSVAYKNVIGARRASWRIVTSIEQKEESKGNESQVALIKEYRQKIEGELAKICQDILDVLDQHLIKSAQSGESKVFYHKMKGDYHRYLAEFAVGDNRKAAADASLEAYKSATEVAQTDLAPTHPIRLGLALNFSVFYYEILNSPDQACHLAKLAFDDAIAELDTLSEESYKDSTLIMQLLRDNLTLWTSSEAEPAAENAPAEKKEEAPAAEGEEKPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B4S1</accession>
    <accession>C8V8I2</accession>
    <name>Q5B4S1_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_04459</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="CBF77477.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
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    </evidence>
    <sequence length="720" mass="78831" checksum="616B58031DEBEA6D" modified="2005-04-26" version="1">MGIVVSEDANRGRNEQQKIDAIVAENDYGLVMVTLDQISVFLGSWWTTSLIGRIQVMPLECHHEEVSGLIERAALGTFGFYFAGIPAWAMSTCLSICRHHPLERLISTFQNFFPNDDAGSKLVRASFTILHSATRGALLVLAMQTYMYSLLQSLHLIPPASMPSIGSFMPFGEFSSMLLPSFPPDLSLCSLSNFAWNFLKTPSLFYIYVYLRPVIEVRLYRLIRRRLPKPKLTDDLSIKVAFENDLVDWMVPTLGRRAAEETQRSKLSLMEDLSYELGALRQWLSSKIPFRSRWSSLVHTAQEQSETPQPQGQPAYRSLDPEEQHRRLRSAQWHPADQTMSTHGSDARSTGSHSALSNEELQAPNTDNMDLLRRARNLTLSTRTSSPGPDTHQHEATTVNGSRRQSHPDTLLSRSQSPVSSQSSPRVRAQFVQESDVIAMQLELESRQTHDRNAIRDSDVELQNAGAGPAGSHSIPDLLDTILSDQGGHITTMLDSEATYNAVDMTDAVHPSHGETITATASGHQPNGVPTGQNAAASSLEPTVSGPTNNPSDVEELAVDADNNQLPNRDDDAAADADSEFPPHLADSAARQNSASDTAATTAFIPSHRVTILSSLPVDSLASHLAAMITAALFAPLESFYLRSLARSYLAYKGAPAVLRSDVYPLGTWGGGRSQSHTLAYLGKLTLMMGIQAAVNASVWGIISGTAIRIGRKWCGWGAF</sequence>
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<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B4Z8</accession>
    <accession>C8V8W1</accession>
    <name>Q5B4Z8_EMENI</name>
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        <submittedName>
            <fullName evidence="1">Kinase-related protein (AFU_orthologue AFUA_4G06710)</fullName>
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        <name evidence="1" type="ORF">ANIA_04382</name>
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        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF77641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_661986.1">
        <property type="nucleotide sequence ID" value="XM_656894.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B4Z8"/>
    <dbReference type="FunCoup" id="Q5B4Z8">
        <property type="interactions" value="9"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5B4Z8"/>
    <dbReference type="GeneID" id="2872186"/>
    <dbReference type="KEGG" id="ani:ANIA_04382"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN4382"/>
    <dbReference type="eggNOG" id="KOG2702">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067202_1_1_1"/>
    <dbReference type="InParanoid" id="Q5B4Z8"/>
    <dbReference type="OMA" id="EVWFVEV"/>
    <dbReference type="OrthoDB" id="6362633at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10285">
        <property type="entry name" value="URIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF77641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="234" mass="26282" checksum="891F798231BD119F" modified="2005-04-26" version="1">MESQVARLVDKIWEKFRTTPENARLLIAVSGIPGSGKTELAITMARRINEKHGAQNGDLIAAAIPMDGYHLTRAQLAQMPDPEYAAARRGAAFTFDGEKFLALVRALREPLTPKTQTLHAPSFDHAVKDPVDNDIPIAAARRVIFFEGNYLSLNKEPWSSAAKLMDELWFVDVDFDTARQRLVKRHVKAGIAKDEADAEKRADENDLVNGREIVDCRLDVQEIIRSSYDPKWED</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="138" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B5J1</accession>
    <accession>C8V4L9</accession>
    <name>Q5B5J1_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mitogen-activated protein kinase kinae mkk2</fullName>
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    </protein>
    <gene>
        <name evidence="13" type="ORF">ANIA_04189</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:17990"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:46609"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="1"/>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF74521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_661793.1">
        <property type="nucleotide sequence ID" value="XM_656701.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B5J1"/>
    <dbReference type="FunCoup" id="Q5B5J1">
        <property type="interactions" value="553"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5B5J1"/>
    <dbReference type="GeneID" id="2873614"/>
    <dbReference type="KEGG" id="ani:ANIA_04189"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN4189"/>
    <dbReference type="eggNOG" id="KOG0581">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_63_23_1"/>
    <dbReference type="InParanoid" id="Q5B5J1"/>
    <dbReference type="OMA" id="KMLEHPW"/>
    <dbReference type="OrthoDB" id="10252354at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000935">
        <property type="term" value="C:division septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004708">
        <property type="term" value="F:MAP kinase kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000196">
        <property type="term" value="P:cell integrity MAPK cascade"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050850">
        <property type="term" value="P:positive regulation of calcium-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060237">
        <property type="term" value="P:regulation of fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd06621">
        <property type="entry name" value="PKc_Pek1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000294">
        <property type="entry name" value="Map kinase kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000263">
        <property type="entry name" value="MAP kinase skh1/pek1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050915">
        <property type="entry name" value="MAP_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47448">
        <property type="entry name" value="DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE DSOR1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47448:SF5">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINAE MKK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="207"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="95"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="118"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="146"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00071969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CBF74521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="502" mass="54272" checksum="329A9EFF25B9C160" modified="2005-04-26" version="1">MSSSPVPLLKAPVPGNRGSSNSPRPPKLTLGIPPSATSRPVAGNGVPIMSDAPQPQRPSGRPAPPQLRLATPMGSTQDVPPQRNVRPMPPPLATTGLNDANGHSRSGSSTHLDGKGSGPASASSSNYSNLSFAMGGLRQPHGGTPDPSSAISSVYSDREGGVQMERDNSVNGLIPDLDKLSLEKGRALDVEDLDDQGWLAASEQKKIVELGSLGEGAGGAVTRCKLKEGKTVFALKIITTDPNPDVKKQIIRELNFNKDCASEHICRYYGAFMDKSTGTISIAMEFCEGGSLDSIYKEVKKLGGRTGEKVLGKVAEGVLNGLTYLHGRKIIHRDIKPSNILLCRNGQVKLCDFGVSGEFGTKGDANTFIGTSYYMAPERITGQSYTITSDVWSLGVTLLEVAQHRFPFPADGTEMQPRAGLIDLLTYIVRQPIPKLKDEPENGIKWSSNFKYFIECCNSLEKEPPRRATPWRMLEHPWVLDMKNKKVNMANFVKQSFDSTVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="130" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B5K5</accession>
    <accession>C8V4N7</accession>
    <name>Q5B5K5_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Zn(II)2Cys6 transcription factor (Eurofung)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ANIA_04175</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF74553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_661779.1">
        <property type="nucleotide sequence ID" value="XM_656687.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B5K5"/>
    <dbReference type="GeneID" id="2873599"/>
    <dbReference type="KEGG" id="ani:ANIA_04175"/>
    <dbReference type="eggNOG" id="ENOG502QV53">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007003_5_0_1"/>
    <dbReference type="InParanoid" id="Q5B5K5"/>
    <dbReference type="OMA" id="IEPWWDS"/>
    <dbReference type="OrthoDB" id="2154091at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051615">
        <property type="entry name" value="Transcr_Regulatory_Elem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF77">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="18"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="104"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="775"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="947"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="143"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="254"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
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            <begin position="823"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="834"/>
            <end position="844"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBF74553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="973" mass="108147" checksum="9845DADAA25920A3" modified="2005-04-26" version="1">MSESGKPKRPPRKHVTTACVPCRESKIRCDGASPHCNNCERKGKHCKYQHGDDKRKVSLRAATELFSARIDQLVQFIYDHGLDPPSMKPEDEAGINRVLDTLQIPRGVSRRKDSPSSDGVVAPKQPSPVQQPAHSPLPVPLFNGQSPENGIGRSESSALPLQNVLSTSHAEQPGANNQESLNSFAFQLPQTSWEFALPTAESLDSLYANMNGGGGYQASLENGYSPESFHLSQDIAQQPGALLEQAQNDRDRDEDSDSGEEDEAEKDVIEQISHRIGTLKIAGDGHLRFFGATSNLNLVDVSATQQRQRPDARTVRHDGQDILNHLRVGQSVDQALEDHLLELYFTWQNCSTYVVDKDMYYTARQKWREEFDDTPFYSEVLTNAMCAIGSAFEARYHPTFITFPKSLAEFFADRAKALLEIELDSPCVATVQALVILSSHEGASNRDARGWLYSGMSMRLAFDLGLHLDMTPYVEKGDMSAYEADVRRVAFWGSYAADHFWGFYLGRPFRMNAGDITVPKPASSLTVGKEGTWRPYGLPANQEALSGELKNPNELISRQFAVLWEIISPLGHVLYGCSDIPRHELQRFCHRVTDDLFAWKANLPSILDIDLADDTTPRLPHLLMLQYTLTRGSLQYHQIVIFTHRPWVSKSYIQPRAPRQGPGYHHARKMCIESSIAIARLLHIYEQHYTFRRMNNQVVSMIFSAALILLYVTISTTPLASRTGLEQLEGSSSEMTAYLNLCFRALDELGQSFENAKRTRDFLVSLQRRWQARMRRSGALKRAGSSQRLSKSSAKDIGGGKGSNHRDASSTRKKSRTSPPTKPHPRPHHHAHNTSLFSLSSSPPHAHHLTTGLETRSTSTFLPSLDLKPVNLHGQTQSLAQRNDIDSWIRDSNLSLLSDNITDTTTAAASAFQMGGASTNPNPGEVDDVDVALPSLEDIDPWWEPGIDGSGHADDTGDRNGNVVGAGAFDDKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B5P4</accession>
    <accession>C8V4Z4</accession>
    <name>Q5B5P4_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_04136</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF74626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_661740.1">
        <property type="nucleotide sequence ID" value="XM_656648.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B5P4"/>
    <dbReference type="GeneID" id="2873556"/>
    <dbReference type="KEGG" id="ani:ANIA_04136"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN4136"/>
    <dbReference type="HOGENOM" id="CLU_658936_0_0_1"/>
    <dbReference type="InParanoid" id="Q5B5P4"/>
    <dbReference type="OrthoDB" id="10675500at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="118"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="204"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="363"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="171"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="207"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="231"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="258"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF74626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="417" mass="46742" checksum="F41EC9116B5CEE92" modified="2005-04-26" version="1">MSSSAYSKRFELPWTASEKQRLWKLKTTGETKDLGWNAFHKLKHFPDRSNSAVQVQWSRLRAERGLPRQRRARGSLESAIPEKRSVACLEDVTESVKFPRTLENADDSEVIGNHVSITSDGEYTEHEGATPDDSVLYQNHSQAPGKTRRLSNPGSDVQHGAAAHSTLSSATIPGSTSTTSEPPSSLSFTPLNFIPIVQETIKKDSRSTLSQAPATCQKQTPGLLDSDESNQLECSMISSRENPHSQPTGRSGMPTHLGPPQTTGPTTVGQAQLPHRLHFSQEEEQLVAQAGHPPTALRTCSESPRLEKASEELVSHVRTFAEDVEHRINDLISSWSLKQKELSILRDSHKKVILERDELRGKLNVEIRENEGFKKEIEDLKAELKLMKEEMRRVEEDKKKITGVYRTLEELIRYAKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B5Q1</accession>
    <accession>C8V502</accession>
    <name>Q5B5Q1_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ANIA_04129</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF74641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_661733.1">
        <property type="nucleotide sequence ID" value="XM_656641.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B5Q1"/>
    <dbReference type="GeneID" id="2873549"/>
    <dbReference type="KEGG" id="ani:ANIA_04129"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN4129"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_2_1_1"/>
    <dbReference type="InParanoid" id="Q5B5Q1"/>
    <dbReference type="OMA" id="SWWNPKG"/>
    <dbReference type="OrthoDB" id="1935484at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000247">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS transporter, putative"/>
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    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF65">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="205"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="266"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="300"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="419"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="451"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="539"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="24"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBF74641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="599" mass="67830" checksum="0C92D9A4045173E4" modified="2005-04-26" version="1">MSAKQPTVCTTPVNGSTPSGSDIESLRSKGASEDMARVPSGATAPPPMAPALASQQSQRMESVLGDAILRFLRIRKDKKPEYDLDAIATQPSIWDSENIEEYKSLYIHPKWENWKAFDPSFRWTCREERAVRRKVDLKIMVWVCVMFAALNIDRNNISNAVSDNMLDDLGLSHSDYNTGQTISRVGFLVAELPSQIISKRIGPDIWIPIQICIFSIISGLQFFLNGRASFLATRYLIATFQGGFIPDTILYLSYFYTSSALPVRLAWYWMSSQLVDIGVGFASVGLLAMRGILGYAGWRWLFLIQGAFTFSVGVASFFLMPQCPAKTKSKWNPKGYFTEKEEKIIVNSVIRDDPQKGGMFNRQGLSVRQIWECIKDYDMWPLYALGLLFGIPKYPVNQYLTLSLRELGFNVIQTNLLSIPYIIGSSITMLLITALSELINNRSFVSMAEDAWLLPCFVALIALPDPIGPWVYFAIATVLLSFPYTHPIQVAWTSRNAGSVQNRTVSASLYNMWVQVSGMIGANIYQSSDSPRYFKANKGLLVICIWMCLVQYPGTYLYYRWRNIQKAKKWDSMSPEEQHHYRQATTDEGNKRLDFRFAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="111" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B5T5</accession>
    <accession>C8V5B3</accession>
    <name>Q5B5T5_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Vacuolar sorting receptor (Mrl1), putative (AFU_orthologue AFUA_1G05730)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">ANIA_04095</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF74717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_661699.1">
        <property type="nucleotide sequence ID" value="XM_656607.2"/>
    </dbReference>
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        <property type="interactions" value="208"/>
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    <dbReference type="GeneID" id="2873516"/>
    <dbReference type="KEGG" id="ani:ANIA_04095"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN4095"/>
    <dbReference type="eggNOG" id="KOG4504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064145_0_0_1"/>
    <dbReference type="InParanoid" id="Q5B5T5"/>
    <dbReference type="OMA" id="RTKSTIM"/>
    <dbReference type="OrthoDB" id="4504960at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.130.10:FF:000024">
        <property type="entry name" value="Putative vacuolar sorting receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.130.10">
        <property type="entry name" value="Mannose-6-phosphate receptor binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028927">
        <property type="entry name" value="Man-6-P_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009011">
        <property type="entry name" value="Man6P_isomerase_rcpt-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044865">
        <property type="entry name" value="MRH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15071:SF0">
        <property type="entry name" value="MANNOSE 6-PHOSPHATE RECEPTOR-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15071">
        <property type="entry name" value="MANNOSE-6-PHOSPHATE RECEPTOR FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02157">
        <property type="entry name" value="Man-6-P_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01404">
        <property type="entry name" value="CIMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50911">
        <property type="entry name" value="Mannose 6-phosphate receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51914">
        <property type="entry name" value="MRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010314142" evidence="10">
        <location>
            <begin position="22"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="MRH" evidence="11">
        <location>
            <begin position="32"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CBF74717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="315" mass="34809" checksum="264DA422027EB3A7" modified="2005-04-26" version="1">MKPLTSRFCFLLASAFTSVYASSDSSGSGELAPCVARSPTTGLYYDLNALHVQPLPSDEKSRKYMRDESWHAKGYDYNANFTLNVCGPVVENITDVVGIEEERWQNVSAYYQTNGKTYSIGQQSSDPFFRGRKLVMNYTDGSPCDDEGSHNKSTIISFLCDRDVTTSTPIFSFVGTMDQCTYFFEVRSSAACGGYGHNPAGQGLSPGGVFGIIALIAVAAYLVGGCAYQRTVMHQRGWRQCPNYSLWAGIVDFLKDMAIICLSSLGRFFNFKRSTTNRASAGADGLQHGQFAGNRRRDVDAENRLIDQLDEEWDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="147" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B5Z2</accession>
    <accession>C8V5K1</accession>
    <name>Q5B5Z2_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 5B</fullName>
            <ecNumber evidence="3">3.6.5.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Translation initiation factor IF-2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">ANIA_04038</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="17">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.3" evidence="3"/>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF74833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_661642.1">
        <property type="nucleotide sequence ID" value="XM_656550.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B5Z2"/>
    <dbReference type="FunCoup" id="Q5B5Z2">
        <property type="interactions" value="452"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5B5Z2"/>
    <dbReference type="GeneID" id="2873457"/>
    <dbReference type="KEGG" id="ani:ANIA_04038"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN4038"/>
    <dbReference type="eggNOG" id="KOG1144">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002656_1_0_1"/>
    <dbReference type="InParanoid" id="Q5B5Z2"/>
    <dbReference type="OMA" id="EFAVMLC"/>
    <dbReference type="OrthoDB" id="4928at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0000247"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006413">
        <property type="term" value="P:translational initiation"/>
        <property type="evidence" value="ECO:0000247"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="CDD" id="cd03703">
        <property type="entry name" value="aeIF5B_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01887">
        <property type="entry name" value="IF2_eIF5B"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="eukaryotic translation initiation factor 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Eukaryotic translation initiation factor 5B"/>
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        <property type="entry name" value="Eukaryotic translation initiation factor 5B"/>
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        <property type="entry name" value="Eukaryotic translation initiation factor 5B"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Translation initiation factor IF- 2, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029459">
        <property type="entry name" value="EFTU-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015760">
        <property type="entry name" value="TIF_IF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023115">
        <property type="entry name" value="TIF_IF2_dom3"/>
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    <dbReference type="InterPro" id="IPR036925">
        <property type="entry name" value="TIF_IF2_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
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    <dbReference type="NCBIfam" id="NF003078">
        <property type="entry name" value="PRK04004.1"/>
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    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381:SF4">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR IF-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14578">
        <property type="entry name" value="GTP_EFTU_D4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11987">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52156">
        <property type="entry name" value="Initiation factor IF2/eIF5b, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 16" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="15">
        <location>
            <begin position="478"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="56"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="134"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
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            <begin position="181"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="213"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="304"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="337"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="378"/>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="425"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="454"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007733"/>
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    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011986"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013824"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
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    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032478"/>
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    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CBF74833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="1072" mass="118859" checksum="591F6EA4602790E9" modified="2005-04-26" version="1">MAPKKKGNRKQEEDWEAELGESIPPAGGDSPAQEEAPGADGDDGEAGGGGLLAALRKNKNKKAKKGKPTNDFVEGEDPIQEANGDADFTSKQPEEGTFDEDDVFAGKKSKPIKAAPPPPAPVDEDSGPRVKTKKEKEREKKEREKQRKREQAAKKKTTEPKQAEQKKPEPKKEEPVAAPSTPAPAPAPEPEPAAGGKKKKIPAHLAAIQKQQEALRKQREEEERRLAEEKAAEEARRLQEEEEARKKEEARQRRKEKEREKKEQLRREGKLLTKAQKEARERNELRMKQMLAAGVGTVAGLQKDQPEKKKPVYENKKKKGPKKQDEDLEAAAARAKAQREAEDERRRKEEEERKAKAEAEAAAAAAAAGDEESELDDWEKAADAEEVKDSWDAPSDDEPEKPAATNDEEITLPERPAAKPAKEEANEESSEEDSDESDSDEEEKSAAQKAIAQRKAEAAERRKKQHEEALAARSKDNLRSPICCILGHVDTGKTKLLDKIRQTNVQEGEAGGITQQIGATYFPVDALRQKTAVVNKDGSFEFKIPGLLVIDTPGHESFSNLRSRGSSLCNIAILVVDIMHGLEPQTLESMRLLRERRTPFIVALNKIDRLYGWKKIDNNGFQESLAMQSKGVQNEFRTRLERTKLLFAEQGFNSELFYENKSMARNVSLVPTSAHTGEGVPDMLKLLTTLTQERMTNSLMYLSEVECTVLEVKVIEGLGTTIDVVLSNGILREGDRIVLCGLNGPIATNIRALLTPAPLKELRLKSQYVHNKEVKAALGVKIAANDLEHAIAGSRLMVVGPDDDEEDIEEEVMSDLENLLSKVSKDQRGVSVQASTLGSLEALLEFLRVSKIPVANISIGPVYKRDVMMCGTMLEKAKEYAVMLCFDVKVDKEAQAYADDVGVKIFTADIIYHLFDDFTKHMAELTERKKEEAKLLAVFPCVLKTVAVFNKKDPIVIGVDVVEGSLRLHTPIAAIKTNATTGAKEVVELGRVAGIERDHKPVNVVKRGQPSVAVKIEGANQPMYGRQLEESDTLYSQISRASIDTLKEFYRSDVSMDEWALIKKLKPVFDIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B674</accession>
    <accession>C8V5Z4</accession>
    <name>Q5B674_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_03956</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF75014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_661560.1">
        <property type="nucleotide sequence ID" value="XM_656468.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B674"/>
    <dbReference type="STRING" id="227321.Q5B674"/>
    <dbReference type="GeneID" id="2873375"/>
    <dbReference type="KEGG" id="ani:ANIA_03956"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN3956"/>
    <dbReference type="eggNOG" id="ENOG502SC6I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014177_4_0_1"/>
    <dbReference type="InParanoid" id="Q5B674"/>
    <dbReference type="OMA" id="AWKVTCA"/>
    <dbReference type="OrthoDB" id="3905365at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="78"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="426"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="331"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="90"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="438"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="452"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF75014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="557" mass="60947" checksum="43DFACEA401F42ED" modified="2005-04-26" version="1">MDDGASTRPADTPEDSGPGEETQTQGTSSKNQALKDRKCQYCNQAFTSSSLGRHLDQFLFKKKPDGIHDVEEIRRIRSGITRRQARTSTGKRDTPDRGLAKGSLDSAQGGEPGGKGPIRMMFNTPTWHATGVINDIPNPSQLQEQAASRFAASQSRMGSFAPTDLGRSSAATNPDTVRALELALREVLDNIKAATSRMRPRISPFEFDIQVQTFPSLCLQLLPPPPTLFAPNPFPSNSSFPLDPPGPDHLNIVRQAIRAKIEQWQSDQLAAESTTNLGKTSLGMDATTIQRNAQQHEELSLRHLELAYKHWLSLPYDSRRDAWQLEIMRAFARESEKRKSLDEQLARVQQEANQLRSQVEKLGTCQWPREFALFPPETLPLPRDVARELDAKESQISPGSARWDYENVVAKWKRVVMHDRTMGRVGISASSPLHDEPTSTAASDSKSRTIQPPSTASPSAGPSPVQNPNANPNPSSPYMSHESPNAAPQAKRQRLMNGRPHPNAPTEQSAAGATQGAPVSSGPWHSVQNQQAQAHVQGPSHGHGHGQQPSPPSPSTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="110" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B6B0</accession>
    <accession>C8V657</accession>
    <name>Q5B6B0_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Protoporphyrinogen oxidase</fullName>
            <ecNumber evidence="4 11">1.3.3.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">ANIA_03920</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>protoporphyrinogen IX + 3 O2 = protoporphyrin IX + 3 H2O2</text>
            <dbReference type="Rhea" id="RHEA:25576"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:57306"/>
            <dbReference type="ChEBI" id="CHEBI:57307"/>
            <dbReference type="EC" id="1.3.3.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="11">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; protoporphyrin-IX from protoporphyrinogen-IX: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the protoporphyrinogen/coproporphyrinogen oxidase family. Protoporphyrinogen oxidase subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.3.4" evidence="4 11"/>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF75090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_661524.1">
        <property type="nucleotide sequence ID" value="XM_656432.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B6B0"/>
    <dbReference type="FunCoup" id="Q5B6B0">
        <property type="interactions" value="490"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5B6B0"/>
    <dbReference type="GeneID" id="2873341"/>
    <dbReference type="KEGG" id="ani:ANIA_03920"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN3920"/>
    <dbReference type="eggNOG" id="KOG1276">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009629_1_0_1"/>
    <dbReference type="InParanoid" id="Q5B6B0"/>
    <dbReference type="OMA" id="EHNQAVQ"/>
    <dbReference type="OrthoDB" id="438553at2759"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00324"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004729">
        <property type="term" value="F:oxygen-dependent protoporphyrinogen oxidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000193">
        <property type="entry name" value="Protoporphyrinogen oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004572">
        <property type="entry name" value="Protoporphyrinogen_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050464">
        <property type="entry name" value="Zeta_carotene_desat/Oxidored"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00562">
        <property type="entry name" value="proto_IX_ox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923">
        <property type="entry name" value="PROTOPORPHYRINOGEN OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923:SF3">
        <property type="entry name" value="PROTOPORPHYRINOGEN OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00419">
        <property type="entry name" value="ADXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0274">FAD</keyword>
    <keyword evidence="5 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8 11" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9 11" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amine oxidase" evidence="12">
        <location>
            <begin position="45"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CBF75090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="602" mass="66252" checksum="8E400A2E53BF43CE" modified="2005-04-26" version="1">MRGSCAASSALKRLERPLAFPCNGQRRFLHAISEGHTVGIIGGGITGLTAAYRLSRDPKCSKVTVYEKGPRVGGWIQSEKINVDGEHIVFEYGPRTLRASTITAFPLLDLLTELGLEDEMLITKTSSAASQNRYIYYPDRLVRMPGPQKGASRISQLITTLKSLLQEPVFESVLPSLLKEPFVKRPLNLPSDESVMEFVSRRWSTKIADNLASSVFQGIYAGNIDKLSAETLLGPLRAHELSGSVAKGITEMKGKQYWISDDFISMLLISEAKKASHLDYLRSLAKDSSTLTFKNGVGQLADALVAELKRSPKVEVLTHANVTSILQDHESSNLTVKVEDGQSRVHNRLIATNPPCDLARQLQCSLEPEKQPTGTINALQRHNYATTTMVVNLYYSNPDLIPVRGFGYLIPRSIPFAQNPERALGVIFASESSVGQDTATGTKLTVMMGGHYWDGWKESDYPDHDTAVSMSQALLKRHLGILDSPKVAHTRLQRDAIPQPTVGHLERMQDISTSIKSELKNRVTLAGAWYSMHGTGVVDSIRQAYLAAKYGPELEYSGAPFPFPSLTDSLGGGGIITHYQPRWITASSEELFRKCGIEKNPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="103" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B6F1</accession>
    <accession>C8V6C9</accession>
    <name>Q5B6F1_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histone acetylase (Eurofung)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_03879</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF75180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_661483.1">
        <property type="nucleotide sequence ID" value="XM_656391.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B6F1"/>
    <dbReference type="FunCoup" id="Q5B6F1">
        <property type="interactions" value="1109"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5B6F1"/>
    <dbReference type="GeneID" id="2873300"/>
    <dbReference type="KEGG" id="ani:ANIA_03879"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN3879"/>
    <dbReference type="eggNOG" id="ENOG502QRFX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_42_5_1"/>
    <dbReference type="InParanoid" id="Q5B6F1"/>
    <dbReference type="OMA" id="KQHAGIN"/>
    <dbReference type="OrthoDB" id="10264707at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052742">
        <property type="entry name" value="Mito_N-acetyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015416">
        <property type="entry name" value="Znf_H2C2_histone_UAS-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43138">
        <property type="entry name" value="ACETYLTRANSFERASE, GNAT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43138:SF2">
        <property type="entry name" value="PROTEIN SPT10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09337">
        <property type="entry name" value="zf-H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="55"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="333"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="457"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="337"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="460"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF75180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="533" mass="60168" checksum="19C358440E638776" modified="2005-04-26" version="1">MPAGHGDLTAMDDESSRDIAPRQLTLRDRVTVATLVPFHSYAHIPKSLIVYLCDQLNREIEKGDTYAMVDPIPVRHFAPYWFSNFGAIMLIGDIKNVNDVQEMDGNVNWAKVCLGSFNVRPNYPGRSSHVCNGMFLVTDAARNKGVGRLMGEAYLDWAARLGYTYAVFNLIYESNVASCRLWEGLGFKRIGRVPNAGRVLSSPGEFVDAIIYGRDLGSDGEDPVTQDRFDKIRYYLKHSKYPRGADRAEKSRLRSAATHYKLVEGENGEEEKLMLKDKEVVSDPQQQYQIAQQVHMEQHAGINKTTAAIAVKYHWVRIKETVSRVIRDCPHCKETLKTPTPTSNSAAETPMDTDEQQEAHQRKRSVQETPAHTHIDAHMSQAEPLQTPQLIHQTQTTIHPGHQHQHQNPFTTPHSSILQGHVGSLSDYTAVPLDPQIMNLHQIPRFQTQETSMADPYGHTHPHQQQHPHPHSFHESVGNVRHVAPNEYRMLVDDPAEDAGTLGLVHSQASDVHHEQMMKYQYVGHGDDELDFT</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-09-23" modified="2025-06-18" version="104" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B6U3</accession>
    <accession>C8V7B2</accession>
    <name>CMR1_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA damage-binding protein cmr1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ORF">AN3737</name>
    </gene>
    <organism>
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">DNA-binding protein that binds to both single- and double-stranded DNA. Binds preferentially to UV-damaged DNA. May be involved in DNA-metabolic processes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the WD repeat DDB2/WDR76 family.</text>
    </comment>
    <dbReference type="EMBL" id="AACD01000061">
        <property type="protein sequence ID" value="EAA59945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF75499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_661341.1">
        <property type="nucleotide sequence ID" value="XM_656249.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B6U3"/>
    <dbReference type="SMR" id="Q5B6U3"/>
    <dbReference type="FunCoup" id="Q5B6U3">
        <property type="interactions" value="670"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5B6U3"/>
    <dbReference type="EnsemblFungi" id="CBF75499">
        <property type="protein sequence ID" value="CBF75499"/>
        <property type="gene ID" value="ANIA_03737"/>
    </dbReference>
    <dbReference type="KEGG" id="ani:ANIA_03737"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN3737"/>
    <dbReference type="eggNOG" id="KOG4328">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017019_1_1_1"/>
    <dbReference type="InParanoid" id="Q5B6U3"/>
    <dbReference type="OMA" id="DPNTLYW"/>
    <dbReference type="OrthoDB" id="9890280at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000001">
        <property type="term" value="P:regulation of DNA damage checkpoint"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000562">
        <property type="entry name" value="DNA damage-binding protein CMR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050853">
        <property type="entry name" value="WD_repeat_DNA-damage-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14773">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14773:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0853">WD repeat</keyword>
    <feature type="chain" id="PRO_0000351108" description="DNA damage-binding protein cmr1">
        <location>
            <begin position="1"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 1" evidence="2">
        <location>
            <begin position="182"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 2" evidence="2">
        <location>
            <begin position="247"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 3" evidence="2">
        <location>
            <begin position="339"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 4" evidence="2">
        <location>
            <begin position="384"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 5" evidence="2">
        <location>
            <begin position="448"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 6" evidence="2">
        <location>
            <begin position="494"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="34"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="214"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="282"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="34"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="227"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="Q12510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="525" mass="58696" checksum="D3F4C1902B1E5829" modified="2005-04-26" version="1">MVKEELSEFEKQRLANIAERDALLKKLSLDAQSTGVFTSNMPRGTSANQSKPKKKPAPKVKKEESLLPRRTSSRLRGIAADSEIAKRKADEEYDRRQEEERAKRVRKSDSFSFNDIFVSGQKLSGDALIGVDVVTKGVAVPYQRTFGEEDIKSTDDKDLKALRKEMNSLSLWEAWEPNRIKITPERIYSMTFHPSEAKPVIFAGDKMGHLGILDASQEKPTSAVKNEDDEDDEDDDDPDPVLVTLKPHTRTISSMTVHPSKPTHLYTASYDSSIRELDLEKTSSVEKYAPESTSDDVPISGLDMAAGDPNTIYWTTLDGAFGRYDMRTKRQSSATTWQLSEKKIGGFSLYQTHPHYVATASLDRTMRLWDIRNLSHTDPTPVGEHQSRLSVSHAAFNCVGQIATSSYDDTLKLYDFSSKGISSWKPGHILDESEMKPDTIVRHNCQTGRWVTILRPQWQLNPQSAIQRFCIGNMNRFVDIYSGSGDQLAQLGGDGITAVPAVAVFHRSKNWVAGGTASGKICLWM</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="122" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B823</accession>
    <accession>C8VHZ4</accession>
    <name>Q5B823_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">alpha-1,3-glucan synthase</fullName>
            <ecNumber evidence="2">2.4.1.183</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ANIA_03307</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[(1-&gt;3)-alpha-D-glucosyl](n) + UDP-alpha-D-glucose = [(1-&gt;3)-alpha-D-glucosyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19749"/>
            <dbReference type="Rhea" id="RHEA-COMP:11150"/>
            <dbReference type="Rhea" id="RHEA-COMP:11151"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28100"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.183"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase group 1 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.183" evidence="2"/>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF82989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_660911.1">
        <property type="nucleotide sequence ID" value="XM_655819.2"/>
    </dbReference>
    <dbReference type="SMR" id="Q5B823"/>
    <dbReference type="STRING" id="227321.Q5B823"/>
    <dbReference type="CAZy" id="GH13">
        <property type="family name" value="Glycoside Hydrolase Family 13"/>
    </dbReference>
    <dbReference type="CAZy" id="GT5">
        <property type="family name" value="Glycosyltransferase Family 5"/>
    </dbReference>
    <dbReference type="GeneID" id="2874399"/>
    <dbReference type="KEGG" id="ani:ANIA_03307"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN3307"/>
    <dbReference type="eggNOG" id="ENOG502QSGC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000488_0_0_1"/>
    <dbReference type="InParanoid" id="Q5B823"/>
    <dbReference type="OMA" id="AWRDHGC"/>
    <dbReference type="OrthoDB" id="512920at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047657">
        <property type="term" value="F:alpha-1,3-glucan synthase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070596">
        <property type="term" value="P:(1-&gt;3)-alpha-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070600">
        <property type="term" value="P:fungal-type cell wall (1-&gt;3)-alpha-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd11323">
        <property type="entry name" value="AmyAc_AGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03791">
        <property type="entry name" value="GT5_Glycogen_synthase_DULL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000058">
        <property type="entry name" value="Alpha-1,3-glucan synthase Ags1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000073">
        <property type="entry name" value="Alpha-1,3-glucan synthase Ags2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000052">
        <property type="entry name" value="Alpha-1,3-glucan synthase Ags2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058659">
        <property type="entry name" value="Mok11-13/Ags1-like_CBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058656">
        <property type="entry name" value="Mok11-13/Ags1-like_GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058657">
        <property type="entry name" value="Mok11-13/Ags1-like_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058658">
        <property type="entry name" value="Mok11-13/Ags1-like_Ig_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058655">
        <property type="entry name" value="Mok11-14/Ags1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058654">
        <property type="entry name" value="Mok11-14/Ags1-like_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013534">
        <property type="entry name" value="Starch_synth_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47182:SF7">
        <property type="entry name" value="ALPHA-1,3-GLUCAN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47182">
        <property type="entry name" value="CELL WALL ALPHA-1,3-GLUCAN SYNTHASE AGS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26127">
        <property type="entry name" value="12TM_Mok13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26122">
        <property type="entry name" value="CBM_Mok13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26108">
        <property type="entry name" value="GH_Mok13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13692">
        <property type="entry name" value="Glyco_trans_1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08323">
        <property type="entry name" value="Glyco_transf_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26114">
        <property type="entry name" value="Ig_2_Mok13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26111">
        <property type="entry name" value="Ig_Mok13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010270425" description="alpha-1,3-glucan synthase" evidence="9">
        <location>
            <begin position="25"/>
            <end position="2444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1090"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2018"/>
            <end position="2040"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2052"/>
            <end position="2069"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2076"/>
            <end position="2094"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2114"/>
            <end position="2131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2143"/>
            <end position="2163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2193"/>
            <end position="2213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2233"/>
            <end position="2250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2270"/>
            <end position="2292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2299"/>
            <end position="2319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2343"/>
            <end position="2363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2375"/>
            <end position="2396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2416"/>
            <end position="2436"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="10">
        <location>
            <begin position="70"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1668"/>
            <end position="1723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1736"/>
            <end position="1797"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1810"/>
            <end position="1860"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1951"/>
            <end position="1990"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1688"/>
            <end position="1700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1739"/>
            <end position="1754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1762"/>
            <end position="1772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1814"/>
            <end position="1826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="1830"/>
            <end position="1844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1973"/>
            <end position="1987"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CBF82989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="2444" mass="272832" checksum="92EBA583B36C7D09" modified="2005-04-26" version="1">MGRLQLSSGLKAIALLTFAATATCWPYDESLVDYNVNTNKSATNPADYWGEWSDHKYHPSPENWRFPFYTLFMDRFVNGDPTNDNINGTTFEHDLNSNQMRHGGDVAGLVDTLDYLQGMGIKGLYLAGTPLMNQPWGSDGYSALDTTLLDQHFGTIQVWRDAITEIHKRGMYVLFDNTIATLGDLIGFEGHLNDTTPFSEKEHKALWKSNRRYVDFDIGNTYNATCDYPRFWYEDGMPVNESLTAGLVGCYDSDFDQYGDIEAFGVWPDWKRQLAKFASVQDRLREWYPPVRERLIRHTCMIIASFDIDGIRYDKATQATVDALGDMSKAYRECARAVGKENFFIAGEITGGNTFGSIYLGRGRQSNQVDSVGNIYDAMKLTNESDPQLFLREVGHEAIDAGAFHYSTYRALTRFLGMDGQLEAGYDVPLDWVQAWGNMTVTNDLINANTGKFDPRHMYGVTNQDVFRWPAIEWGVERQMLGSFITTLMLPGIPLLLWGEEQAFYVLDATASNYIYGRQAMSSATAWKTHGCFSLESSQYYQWPLVAALDGCNDETVTYDHRDPSHPVRNIIKHMYQMREQYPMLNDGFIIETLSNQTEPVYYPGSNGTETETGMWSVRRDRNEETQDFGSSDDNEPIWLVYSNMNRTHDYTFDCSDNETALIAAFPSGTKVRNLFHPYDTLTLGDGPKEMVYGNSTELVGCLPNLTLSRYEFRAYVKNELWKKPRPMITKFQPGDDEANGHDSPLRSTVAPDASETVRLTLQFSEAMGCDSVTDSISFNSSTETGKIPSIDASTVQCGNITEVANSNATGHIPGKWQWAADLRGVYNGIHRVTVNNASNADGDDSTHAVDHFLFRIGQIDNPMVFTSANYSSSLLHEKEDGTFYIQHHAAGADKYRYSTNWGTTFSDWKTYKGGNDTITMLPWNGTKAQEWEGHHIRVEYWSRWTGSSSHVQEGDSGWKYKTPRRFPHAFFNGPYNQYGYDGGLDNQIKLDAGAGGDGYWKYHFTSEWPAVGQVNVWGINPDGEPDQSWVMGDVDGDKVLDRMPPSALSATLINITDHPTHPYISWKLYINDATMRYYLIPAGHQSGQIAMFVLFWIIPLLSGSACVYIFMKSFYKVKFNEIGAAGASTEMKSLVPLALRRRMKQLASGNGKNGPSFNPLMRLAEKSGFMQSTTALAGAASGKRRMVLIATMEYDIEDWGIKIKIGGLGVMAQLMGKTLGHQDLIWVVPCVGGVDYPVDTPAEPMTVTILGQAYQVNVQYHVLKNITYVLLDAPVFRQQTKSEPYPARMDDLDSAVYYSAWNQCIAEAIKRFPVDLYHINDYHGSVAPLYLLPGTIPACLSLHNAEFQGLWPMRTQKEKEEVCSVFNLDVEVVRNYVQFGEVFNLLHAGASYLRVHQQGFGAVGVSKKYGKRSYARYPIFWGLRKIGNLPNPDPSDVGEWTKEDSLIKDEDIKVDPEFEAGRAELKRQAQEWAGLDQNPDADLLVFVGRWSMQKGVDLIADVMPAVLEARPNVQLICVGPVIDLYGRFAALKLDRMMKVYPGRVFSRPEFTALPPYIFSGAEFALIPSRDEPFGLVAVEFGRKGALGIGARVGGLGQMPGWWYNVESVSTSHLLMQFKLAIEAALSSKTETRAMMRARSAKQRFPVAQWVEDLEILQSTAIQVHEKEVSRGHAGGRPMTPMTPSGATTPSGMMTPTTGSRGLKPLSQGVGMGLSVPHSRESSYSNLNRLSEYVAQKTPGESQPRESSGLQRSLSLGVRSGPGHRGRARKQKPGADNIPEGNEDGSSSDTESIPDYYDDEYTLTPAQIEESRRAQATRSISFSPETLQPPRSPLPAPPMSPGTPPSVEQTLLPPPKPFAAADAGNRLSSASVLSLDSVVGGKKDFKLQKVDPFFTDSNGEYARNFEQQLENLNGSNSESQLCIEEFLVKSERRWFNKFRDARLGRLRSPTPSVFRDNHSHGRGSPDGSMYVDEAGHRNSGDAVHDNGSDDTDDEFLLGKDYVPPTGLKKWMQIKIGDWPVYTLFLALGQIIAANSYQITLLTGEVGQTAEKLYGIATTYAITSALWWLVFRYFKSIVCLSTPWFLYGIAFLFIGSAHFESDSFTRGWIQNVGSGFYAAASSSGSIFFALNFGDEGGAPVSKWIFRACVIQGIQQVYVIVLWYWGSTMAHQSSQGLLTADNTISNTWKMTAICYPIAMLLWAIGLLLIFGLPNYYRQKPGKVPSFYKSLFRRKIVLWNFVAVILQNFFLSAPYGRNWSFLWTSSHTKPWQIVILCVIFFGLLWCAFLYIVAVLSKQHSWFLPVFACGLGAPRFLQIWWGVSGIGHYLPWVAGGYTGGALVSRSIWLWLGVLDSIQGLGFGIILLQTLTRMHMCFTLIVSQVLGSIATIVARACAPNNVGPGPVSPDITKGAGELANAWFWVALFCQLLVCAGFLLFFRKEQLAKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B9Q2</accession>
    <accession>C8VJZ9</accession>
    <name>Q5B9Q2_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dihydrodipicolinate synthetase family protein (AFU_orthologue AFUA_6G00110)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_02728</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
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            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
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        <source>
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        </source>
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    <sequence length="309" mass="33672" checksum="DA552AF4E09CC5A4" modified="2005-04-26" version="1">MVGFDMHGLTPAPVTPFTPTGEIDYDAIQRLGSWLSSMNGVKGLVVLGHAGEGTFLTAEEQVAVIKAFVKSVDDKIPIIAGITGEGTEVAALEAQRAKAAGAKAGLLYPSHGWLRFGYQDGAPQDRYRRVYEVSNLPLILFQYPDNTKATYSLQTMLDIAAQPGVFAMKNGVRNMRRWDTEIPVIRRERPDLQILSCHDEYLLHTAFDVDGFLVGYGNIAPEPLIELIEAGKAKDYRRARAIHDRLLPVTKSVYHRGSHMEGTVALKHALVARGILSHATVRSPLRPLEAGAEQEIHAAIGTAALGKVA</sequence>
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<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
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            <taxon>Eurotiomycetidae</taxon>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
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            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
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        <source>
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        <source>
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    </evidence>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="111" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="7" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
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            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FMO family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF84329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_660233.1">
        <property type="nucleotide sequence ID" value="XM_655141.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BA01"/>
    <dbReference type="GeneID" id="2874546"/>
    <dbReference type="KEGG" id="ani:ANIA_02629"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN2629"/>
    <dbReference type="eggNOG" id="KOG1399">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019225_1_0_1"/>
    <dbReference type="InParanoid" id="Q5BA01"/>
    <dbReference type="OMA" id="HTEFCAL"/>
    <dbReference type="OrthoDB" id="2915840at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="197"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBF84329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="613" mass="69214" checksum="70A87ECEF0E8420E" modified="2005-04-26" version="1">MEPRTIDLVIIGAGWHGLAAAKTALALNPDLSLLVLDSATSIGGVWAEERLYAGLRTNNLLGSYEYSDFPMSDNVMPGLVEAGQHIPGRAVHEYLKAYADRFGIRDKIWLNCKVESVEYIKGYAERKEWVVRYINAAGTGHAKDGCIRTRKLILATGLTSQPRIPIFAGQDSYGAPLFHVKELALYQNILFSKTNDKTEDQNMGTEEEEEDYEGTRDDQPPLTVLGGSKSAWDTVYACASRGHRVNWVIRSSGTGPSWMSPAAVFSPLNLLLESLPLVRALSWFSPCIWVSSPIRRFLHGTWLGRIIVRLFWASLEWDILRVNRYSDHVETAKLRPWIKPIWAGTAVGILNFSHNFFSLIRQGLVKVHIADIERLERHTVVLSNEDKLYTRAVILCTGWKASPGIRFLPDGIEQELGLPWTADSLDPELIEQTRKNIHTRLPMLGTVPEARSYHDKKDVNETVLHPFRLARFIVPPSLWDDHSITVLGTVTTFNTPLVTEVQALWVLVYLNHGNELHYDCHDKESLLRETALHTEFCALRSPADHGARNADFVFEVLPYLDMLLLDLGLRTARKGSWWKNLFVPHQPRDYAGLVEEWKGRVSVANKGGRIKID</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="110" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BA66</accession>
    <accession>C8VPV1</accession>
    <name>Q5BA66_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aminotransferase, putative (AFU_orthologue AFUA_4G00630)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ANIA_02564</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF87107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_660168.1">
        <property type="nucleotide sequence ID" value="XM_655076.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BA66"/>
    <dbReference type="STRING" id="227321.Q5BA66"/>
    <dbReference type="GeneID" id="2874779"/>
    <dbReference type="KEGG" id="ani:ANIA_02564"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN2564"/>
    <dbReference type="eggNOG" id="KOG0256">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_1_2_1"/>
    <dbReference type="InParanoid" id="Q5BA66"/>
    <dbReference type="OMA" id="MYGSEEF"/>
    <dbReference type="OrthoDB" id="7042322at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050478">
        <property type="entry name" value="Ethylene_sulfur-biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43795">
        <property type="entry name" value="BIFUNCTIONAL ASPARTATE AMINOTRANSFERASE AND GLUTAMATE/ASPARTATE-PREPHENATE AMINOTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43795:SF63">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G00630)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00753">
        <property type="entry name" value="ACCSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="3">
        <location>
            <begin position="56"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBF87107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="451" mass="49865" checksum="8AC17B5977598F76" modified="2005-04-26" version="1">MTSHTFIERQETMLGPSASTLSRRARSSLKCTSNALWDVLNDIWHPQSNPHGYVTLGVADNTLMQQQLLFRANSSFEMSGQHLALNDTITGSPRLKAAIADILSRYLHPSKLLRPSHILATNGVASAIEHCSWALCDPGDGILVGRPYFRGFSRDICLRPAARLVQVSFEGVDPLGISAVSIYEEALINSSKQGCAIRAIMICNPHNPLGRCYSQSFLIEIMKLCQRFGVHLISDEIYALSVWREGQDGAVSMNKFTSVLSIDHDGLIDPSLVHVLWGVSKDFGANGMRLGAVISQGNSDMLESIRGVAQYSSVSGLADCFTTNILEDERFVNQFIAENNKALAATYEYVVAFMDRHGIPYARGSNAGFFVWCDLLTPYLKLQPASSFDGSEKAKAIKNRELLDKLSRFKVHLGVGDDFGSEQKGWFRITFSQSQEQLDEGLARIIDALRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="99" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BBG4</accession>
    <accession>C8VLZ7</accession>
    <name>Q5BBG4_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD dependent epimerase/dehydratase, putative (AFU_orthologue AFUA_7G00180)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_02116</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF86210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_659720.1">
        <property type="nucleotide sequence ID" value="XM_654628.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BBG4"/>
    <dbReference type="FunCoup" id="Q5BBG4">
        <property type="interactions" value="21"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5BBG4"/>
    <dbReference type="GeneID" id="2875272"/>
    <dbReference type="KEGG" id="ani:ANIA_02116"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN2116"/>
    <dbReference type="eggNOG" id="KOG1502">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_12_3_1"/>
    <dbReference type="InParanoid" id="Q5BBG4"/>
    <dbReference type="OMA" id="DPMAGNY"/>
    <dbReference type="OrthoDB" id="10262413at2759"/>
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        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051783">
        <property type="entry name" value="NAD(P)-dependent_oxidoreduct"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079:SF5">
        <property type="entry name" value="DEPENDENT EPIMERASE_DEHYDRATASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G00180)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079">
        <property type="entry name" value="PROTEIN YEEZ"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF86210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="316" mass="33931" checksum="8EC187F7E71F220A" modified="2005-04-26" version="1">MSQKVFVTGATGFIGRKVTEFAVKEGYSVRGLSRREEGDALFESLGATPVRGDLKNADLLTEESRNADIVLHLAFDHDFTKPYQELVNTDIAAVTALAKGLEGTGKPLVVSNGTANVAPDPNGGETDEDAPLADHLLTNRDGAERHALSFVDKSVRVVSIRLPQYVYGPGSTTGFAAQLIKLAIRSGESVYIGDGEYCFSDTYVDDAAKLYLLAAKHAKPGDVFNGTGHTTTTYRAMATAISELVGVPARSITPDEAVARWGPFLAGFISIRNRASNRRAVEQLGWKPVGPGLLWEVRNGSYVPVAEKFKKEASAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BBH9</accession>
    <accession>C8VLY0</accession>
    <name>Q5BBH9_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">KAR9-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_02101</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF86180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_659705.1">
        <property type="nucleotide sequence ID" value="XM_654613.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BBH9"/>
    <dbReference type="STRING" id="227321.Q5BBH9"/>
    <dbReference type="GeneID" id="2874636"/>
    <dbReference type="KEGG" id="ani:ANIA_02101"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN2101"/>
    <dbReference type="eggNOG" id="ENOG502QUB2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005577_1_0_1"/>
    <dbReference type="InParanoid" id="Q5BBH9"/>
    <dbReference type="OMA" id="IWIKKAS"/>
    <dbReference type="OrthoDB" id="5559380at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051293">
        <property type="term" value="P:establishment of spindle localization"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031578">
        <property type="term" value="P:mitotic spindle orientation checkpoint signaling"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030473">
        <property type="term" value="P:nuclear migration along microtubule"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="entry name" value="Karyogamy_KAR9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37271">
        <property type="entry name" value="KARYOGAMY PROTEIN KAR9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37271:SF1">
        <property type="entry name" value="KARYOGAMY PROTEIN KAR9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08580">
        <property type="entry name" value="KAR9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="102"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="143"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="246"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="737"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="575"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="56"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="151"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="188"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="262"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="746"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="765"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="799"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="836"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="859"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="877"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="911"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="932"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1001"/>
            <end position="1010"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF86180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1010" mass="109749" checksum="BEF58BED5869F332" modified="2005-04-26" version="1">MRAIFTTSSHPSAPAPDTSTSATTSQGSPPPPPPPLVSVSSPDESATPRRIKSKASLRSTRSIGSSLLHEDDGDDAQSEKSLIRPNILRRLSPGLAARVKLLDGSSKTATSPRNPGAVGRIPEEQIKELDSLHKVQSIEVERKGRAWSGISFANKTQKQQVQREPLPQSGVPEPPVAESTPGSGQDATSDRLETKEEKVENTPTTMSVVEPAPAPLGPEISDPNIEDQTDGPTDYEKYIQKTSELEAEANGAPRPPPKDSPPIQSSASSNTQSYFNPHGLHRTSSIYSSTNSIFSFSRSSFSNQISQLTSIALPQPSSLEASIASISNAPAAVKALTGAAEQIQIWIRKASNVLNGLDAEDDVVWAAAAGREGLDGVDKAITKFESLVNVYVKAIEDVQLREDIANVSTDGLETIVTQMDSILQSWANIKSRLRAVKEQVELAMEWEELWNSVLGDVGEEVEELEGLVFEMEAKRHFNLANEDSTGLDINELETIVEETPSSGRFLNKRSSMGSLYPAPPALDRPIIQTPQDDTNHSNLVELFARLQPLRASLDFLPMRLSMFQSRAEKVFPSACTELMERREKLEKDYKNLQADAETLRKELEEDRWIMVFRNAGSQAQKMFESVERSISKLQEGLETGMHLHNPAGMTNRIESYEAKKQHYVPAIDRVLTITQKGVKDRLTVNGEILRLLANMESQVNALRASIKVMDSSLEDIQDLRSQHMRDSISTVLTIDSPATGSLADTPGSSPASSVVMTPANKSSRRGSSVGSAARTSTGRRVSGLPQLASNLTGRKPSNPKATPKTTLTAPSPTPAARKPAQPAQPALSPALLNRPRWNTSTNTNDLDVGHKYKPWTPSLRKQTAPSRGTRPSSTIPPRDPSTSPVPPTARSASRISSRLGLRSPGRTASPSPSPSILDPPPYSKLRRPAGTENMSNTPRSRQSFAGTSFNRSVSQEQGRSDSPTKAARPGTALGHSGSRRISLLPLPRNRNKDNFPSTRSKLSERPPWRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BCP7</accession>
    <accession>C8VNT1</accession>
    <name>Q5BCP7_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Oligosaccharyltransferase subunit ribophorin II, putative (AFU_orthologue AFUA_4G08660)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ANIA_01683</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF85360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_659287.1">
        <property type="nucleotide sequence ID" value="XM_654195.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BCP7"/>
    <dbReference type="FunCoup" id="Q5BCP7">
        <property type="interactions" value="140"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5BCP7"/>
    <dbReference type="GeneID" id="2874709"/>
    <dbReference type="KEGG" id="ani:ANIA_01683"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN1683"/>
    <dbReference type="eggNOG" id="KOG2447">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051361_0_0_1"/>
    <dbReference type="InParanoid" id="Q5BCP7"/>
    <dbReference type="OMA" id="VFFMYYT"/>
    <dbReference type="OrthoDB" id="432292at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056790">
        <property type="entry name" value="Ribophorin_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008814">
        <property type="entry name" value="Swp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12640:SF0">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12640">
        <property type="entry name" value="RIBOPHORIN II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25147">
        <property type="entry name" value="Ribophorin_II_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044312547" evidence="8">
        <location>
            <begin position="23"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="191"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="235"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="259"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="Ribophorin II C-terminal" evidence="9">
        <location>
            <begin position="182"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF25147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBF85360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="290" mass="30917" checksum="4F8826E458C36CD2" modified="2005-04-26" version="1">MLWWQTLFQLSLLSSVALPAAAAAASWGFTDATVSVQTKGAGVGAGFKEEIPRNGALSSPVSLGNADTLKVALTTQEGKSAKSAHQVFLMLQDPKTGLDISYPFSVKGNGKSRVELTWKDLPVQFLSTSEPLDARILIGSFGSSAAYNKPAFQLSLARNPNEPVPTYEVSRYGQLPEIHHIFKSDPQSPPVAVTLLFIAIVLAIFPVLGGVWLYLGANINHLPVALKSAPIPHAVFLGSLLAIEGIFFLYYTSWTLFQILPAVAAAGTVAFISGSRALGEVQGRRLAGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="135" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BE67</accession>
    <accession>C8VT31</accession>
    <name>Q5BE67_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Oligomeric mitochondrial matrix chaperone (Eurofung)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ANIA_01163</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ClpA/ClpB family.</text>
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        <property type="protein sequence ID" value="CBF88019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_653675.2"/>
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    <dbReference type="GeneID" id="2876935"/>
    <dbReference type="KEGG" id="ani:ANIA_01163"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN1163"/>
    <dbReference type="eggNOG" id="KOG1051">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="InParanoid" id="Q5BE67"/>
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        <property type="component" value="Chromosome VIII"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="RecA-like_ClpB_Hsp104-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ATP-dependent chaperone ClpB"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ATP-dependent chaperone ClpB"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ATP-dependent Clp protease subunit"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Chaperone clpB 1, putative"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018368">
        <property type="entry name" value="ClpA/B_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028299">
        <property type="entry name" value="ClpA/B_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041546">
        <property type="entry name" value="ClpA/ClpB_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050130">
        <property type="entry name" value="ClpA_ClpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11638">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11638:SF176">
        <property type="entry name" value="HEAT SHOCK PROTEIN 78, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF17871">
        <property type="entry name" value="AAA_lid_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00870">
        <property type="entry name" value="CLPAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00871">
        <property type="entry name" value="CLPAB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="8">
        <location>
            <begin position="122"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="8">
        <location>
            <begin position="521"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="domain" description="Clp ATPase C-terminal" evidence="9">
        <location>
            <begin position="699"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="335"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBF88019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="800" mass="88640" checksum="85B231A206E4AF4A" modified="2005-04-26" version="1">MASRLQLSRSRLLRPSNLTYTPSNRLVRPCPSLRILPRARLPSLSTNIAAPLSSSSIRNYASGRPHPPGGTHRMNLGGEPEKAALEQYGVDLTAKAKAGKLDPVIGRDSEIHRTIQVLSRRTKNNPVLIGAAGTGKTAVLEGLAQRIVQGDVPESIKGKRVIALDLGSLIAGAKFRGDFEERLKSVLKEVEEAQGGVILFIDELHTLLGLGKAEGSIDASNLLKPALSRGELQCCGATTLNEYRLIEKDVALARRFQPIQVGEPSVAATISILRGIKDKYEVHHGVRITDGALVAAATYSNRYITDRFLPDKAIDLVDEAASALRLQQESKPDIIRELDRDITTIQIELESLRKETDISSRERREKLEEDLKAKREESRKLTEIWEKEKAEIESLKRTKEELERTRFELEQAQREGNFAKAGELRYSKIPSLEAKLPKEGDEQKDPQSTLIHDSVTADDIGAVVSRTTGIPVSKLMAGEVEKLIHMEDTLRQSVRGQDEALSAVANAVRMQRAGLSGENRPLASFMFLGPTGVGKTELCKKMAEFLFSTETAVVRFDMSEFQEKHTISRLIGSPAGYVGYDDAGQLTEAVRRKPYAVLLFDEFEKAHRDISALLLQVLDEGFLTDAQGHKVDFRNTLIVLTSNLGADLLIGADPIHSSKASTDGEITPELKKAVMDVVQQAYPPEFLNRIDEFIVFKRLSREALRDIVDIRIKELQSRLDDRRMTLQVDDEIKDWLCEKGYDPKFGARPLNRLISKEIGNRLADKIIRGEVTSGQMARVAFNANNDGLEVTAVAQGEEQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BF29</accession>
    <accession>C8VQ19</accession>
    <name>Q5BF29_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">EXPERA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">ANIA_00851</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
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            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="17">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
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    </reference>
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        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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    <comment type="similarity">
        <text evidence="2">Belongs to the EBP family.</text>
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        <property type="protein sequence ID" value="CBF88659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="XP_658455.1">
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        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_072128_3_0_1"/>
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        <property type="component" value="Chromosome VIII"/>
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    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047750">
        <property type="term" value="F:cholestenol delta-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="EBP"/>
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        <property type="entry name" value="EXPERA"/>
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        <property type="entry name" value="3-BETA-HYDROXYSTEROID-DELTA(8),DELTA(7)-ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14207">
        <property type="entry name" value="STEROL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05241">
        <property type="entry name" value="EBP"/>
        <property type="match status" value="1"/>
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        <source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01087"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CBF88659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="123" mass="14477" checksum="539E63892C0FD369" modified="2005-04-26" version="1">MINHGRMGSAQDFFGQLWKEYALSDSRYLTSDTLVLCMETITVIIVCMAHLYGDTLYFATSIYDDHAHERPYCRPEPFYFWVYYFGMNFIWIVVPAIYLYQSMKAISYAMKKAEKISQSLKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BF94</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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        <name evidence="2" type="ORF">ANIA_00786</name>
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        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
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        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF88787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_653298.1"/>
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    <dbReference type="OrthoDB" id="4158189at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="35"/>
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        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF88787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="200" mass="21231" checksum="5BE8C201EEB1D5D1" modified="2005-04-26" version="1">MCGPARASSGHRIAIMFPSPTSSPSSSLSSSPSSSPSPSPSPSLSPSPSLSDSDSEPYSLFFRQPTPESPEHTSAVFQIKDSSTINTFRSCQAIDLRIERHGDLTLSSSIHPPLHQFQLRPLLSFPSKAELGMNETGNEIEFSLPERLDLNISDRGIVGRQVTVVARGGNGEVLRMGRGIVGSSCRSSSLFTGQVSSQAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="101" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BFN7</accession>
    <accession>C8VS11</accession>
    <name>Q5BFN7_EMENI</name>
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        <submittedName>
            <fullName evidence="6">Signal recognition particle 19 kDa protein, putative (AFU_orthologue AFUA_1G16820)</fullName>
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        <name evidence="6" type="ORF">ANIA_00643</name>
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    <organism evidence="6 7">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
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            <taxon>Eurotiomycetes</taxon>
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            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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    <reference evidence="7" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
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            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
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                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
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            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
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    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
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        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="CBF89073.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="257" mass="28200" checksum="B8BAA948F7E35C29" modified="2005-04-26" version="1">MSRNAQVEEVYDSDPEEVAPSLVPSHAKNDSILSGASIPTSSMPIRPAPEPQREIPKSYQCLYPVYFDKTRTRAEGRKVGTELAVENPLARDIVDAVQMLGLRVGFEPEKLHPKDWANPGRVRVQLKDENGEPVNSQIKNKHHLYILIAQYLKAHPTTDQSPYRLRIRGLPMPEKLPDAPPAPRGWKIGKILPIHSAAYSGGGVSDNPLKDAMAEMQNMQGMPGMPQIPGMGNLAGMMGGGEPSGGSEKKKKDKKKK</sequence>
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<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
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    <accession>C8VS15</accession>
    <name>Q5BFP1_EMENI</name>
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        <name evidence="2" type="ORF">ANIA_00639</name>
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        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
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            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF89081.1"/>
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        <property type="nucleotide sequence ID" value="XM_653151.1"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
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        <property type="component" value="Chromosome VIII"/>
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        <location>
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        <location>
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        </location>
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    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CBF89081.1"/>
        </source>
    </evidence>
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        <source>
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    <sequence length="406" mass="45953" checksum="FAC360467D724739" modified="2005-04-26" version="1">MPKRRTKTASTVQDYPLKLPNLSRADLQALIEVLAIEPPQPSHPLYGENVKQQIQEAVNKLRPALRKRLLIFSPSTPAPAATLCISHKRLNQYIINHIFRLIQREVEDHLDNITQRYPGYPDSLESHVLNIVRNLQSLRGLWWDHASSRSSPIDPVPFQQNKCEACIISRIIVRPGALQDLRTALLSRTRERCSYRLPPKLTRFVDGALYYRQGKSLLSLIQYSTKLSSDLKQARKNAARRTTRQHSRRCDGSKCEPRLPSRIVTDHQLISKPTEEPSGSALTSLSPNFESGGRESPQTIKLWLVPKTVSPFELEKKLKEDQKVKDQRKIQDLLIQEILSAYGPFRTSMEVAASLNLDSRDISDATATQGYDINSTNYAPRKSSSDLSDWENDLGDKSITIDSGSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="125" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BFW0</accession>
    <accession>C8VSD9</accession>
    <name>Q5BFW0_EMENI</name>
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        <submittedName>
            <fullName evidence="6">Ribosomal protein L26 (AFU_orthologue AFUA_6G11260)</fullName>
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        <name evidence="6" type="ORF">ANIA_00570</name>
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            <taxon>Eurotiomycetes</taxon>
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            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
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        </lineage>
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    <reference evidence="7" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
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            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL24 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF89212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_658174.1">
        <property type="nucleotide sequence ID" value="XM_653082.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BFW0"/>
    <dbReference type="FunCoup" id="Q5BFW0">
        <property type="interactions" value="886"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5BFW0"/>
    <dbReference type="GeneID" id="2876347"/>
    <dbReference type="KEGG" id="ani:ANIA_00570"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN0570"/>
    <dbReference type="eggNOG" id="KOG3401">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093240_0_1_1"/>
    <dbReference type="InParanoid" id="Q5BFW0"/>
    <dbReference type="OMA" id="VRIMRGD"/>
    <dbReference type="OrthoDB" id="1688503at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030684">
        <property type="term" value="C:preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd06089">
        <property type="entry name" value="KOW_RPL26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000009">
        <property type="entry name" value="60S ribosomal protein L26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01326_A">
        <property type="entry name" value="Ribosomal_uL24_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005825">
        <property type="entry name" value="Ribosomal_uL24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005756">
        <property type="entry name" value="Ribosomal_uL24_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041988">
        <property type="entry name" value="Ribosomal_uL24_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01080">
        <property type="entry name" value="rplX_A_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11143">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L26 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16906">
        <property type="entry name" value="Ribosomal_L26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01108">
        <property type="entry name" value="RIBOSOMAL_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="KOW" evidence="5">
        <location>
            <begin position="49"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBF89212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="134" mass="15215" checksum="8AEA216B2CEF8508" modified="2005-04-26" version="1">MAVTNQAISSSRRKSRKAHFNAPSSVRRVIMSAPLSKELREKHNVRSIPIRKDDEVTIVRGTNKGREGKITSVYRLKWCVHVERVVREKSNGQSVPLPIHPSKVVITKLKLDKDREQILERISKGREAVKAKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BGC5</accession>
    <accession>C8VTI1</accession>
    <name>Q5BGC5_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ER membrane protein complex subunit 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ANIA_00405</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EMC6 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF89552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_658009.1">
        <property type="nucleotide sequence ID" value="XM_652917.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BGC5"/>
    <dbReference type="STRING" id="227321.Q5BGC5"/>
    <dbReference type="GeneID" id="2876182"/>
    <dbReference type="KEGG" id="ani:ANIA_00405"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN0405"/>
    <dbReference type="eggNOG" id="KOG4455">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_110781_0_0_1"/>
    <dbReference type="InParanoid" id="Q5BGC5"/>
    <dbReference type="OMA" id="PDSVMHN"/>
    <dbReference type="OrthoDB" id="16510at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008504">
        <property type="entry name" value="Emc6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029008">
        <property type="entry name" value="EMC6-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20994">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20994:SF0">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07019">
        <property type="entry name" value="EMC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBF89552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="143" mass="14882" checksum="E4CE208E1FC7A571" modified="2005-04-26" version="1">MPPTKQELSLLINPLVPESVQHNNRVLTQLHSLTSFLLGLTAGILALQSAAGFIFYFLGTITVSGLFHLALLYRSAGKGAGGYFPGAGGEIEGLVVQKDGIVKNAGSGMRKGAWRDVWFGGGVLGEALSGFVLGWAGVGGVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BGH7</accession>
    <accession>C8VTT6</accession>
    <name>Q5BGH7_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F-box domain protein (AFU_orthologue AFUA_1G02120)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_00353</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF89659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_657957.1">
        <property type="nucleotide sequence ID" value="XM_652865.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BGH7"/>
    <dbReference type="GeneID" id="2876129"/>
    <dbReference type="KEGG" id="ani:ANIA_00353"/>
    <dbReference type="eggNOG" id="ENOG502SHIS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012775_0_0_1"/>
    <dbReference type="InParanoid" id="Q5BGH7"/>
    <dbReference type="OMA" id="ICPGRRC"/>
    <dbReference type="OrthoDB" id="1689567at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="61"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF89659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="732" mass="81079" checksum="7E5B440218B23D16" modified="2005-04-26" version="1">MPGVVNPLIYDTDFDAQSTNVIHPSVAERCSESVAETSCWPLRLAPNPWAQAIDEALPLQRAPANTLPPEILTQIFYELSPRDFDNARRVCSQWMRASLNERLLESMLKRAGWWDSWLRDNKNQRRKMNVERTGFVTTTVVDFSQLSQAGQTSTSRDLSYPYPSSKDVSFTSGFHVSNCGNNLLVISGCNIHIYQLLGRRRVGSAPMSKEDLGNVDIAPVASITCPTEVLSATIDTSTSNFNVAALLRNRLGTICELAPVDRGGNFSSMDFVHNGTNSCCARGRHSASAFSKKITSRHFFYDVCSVHDPPLSISICPGYRCVAFGSESGIELRWVDQETNIDCRKYLPMSQPSEILHFMPNRLDTPLEFRLISSVAGPGVEGCRCQTLSAGELHPSCPFHTVKEDVQTFSRWAPERKDQVGLVRTTQCHHYRAVPVNDGIHLLFVEPRSGYLCIGSNAPLDGPTCLTRALVCVPPFKNDTPNGSQDAPVPTVFASGSDLSWGLRIVAAYGNRLVFYSVPLDVFNVLKNERERQGDGVMADSDLARDFFLIQSDRPHRESLTSNQNEDWEFLLSVSYRPTAMMWPFKIYGKEIGRVQNVVEIALQSSHGCARIWVFSASGETNIIDVDTFTSASQDASKFPCKSFTIGSDGRIVDAQLVSRSEHCLVTPGNLRERKKTKSRAGFSGRHMLCRYSSSMSDGGRDATAANVFDAQIVNVSIPELGGRHAQPEVVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BGP7</accession>
    <accession>C8VUB8</accession>
    <name>Q5BGP7_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_00283</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF89813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_657887.1">
        <property type="nucleotide sequence ID" value="XM_652795.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BGP7"/>
    <dbReference type="STRING" id="227321.Q5BGP7"/>
    <dbReference type="GeneID" id="2876060"/>
    <dbReference type="KEGG" id="ani:ANIA_00283"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN0283"/>
    <dbReference type="HOGENOM" id="CLU_1454387_0_0_1"/>
    <dbReference type="InParanoid" id="Q5BGP7"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF89813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="186" mass="20787" checksum="2C80BF0F2D7BBA17" modified="2005-04-26" version="1">MAETLRVTQLALRGTLPGGPPGRPCGTLVAFGGPERAVNEFSTNDRAATEAARGLYKAALLAMLAVREPQIWQNNSKALLGQMHACKCAAALAALVAGEEEEEEEEEEEEEEEEDEEEEENARRRKGKAPATSARKGVHFASHDTREHADRVPRRAQRLHTCWPWQPDRYLPPLLPRKLSPRRCSW</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-05-31" modified="2026-01-28" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BGS2</accession>
    <accession>C8VUJ6</accession>
    <name>LCL3_EMENI</name>
    <protein>
        <recommendedName>
            <fullName>Probable endonuclease lcl3</fullName>
            <ecNumber>3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">lcl3</name>
        <name type="ORF">AN0258</name>
    </gene>
    <organism>
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location>Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the LCL3 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-"/>
    <dbReference type="EMBL" id="AACD01000005">
        <property type="protein sequence ID" value="EAA66131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF89865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_657862.1">
        <property type="nucleotide sequence ID" value="XM_652770.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BGS2"/>
    <dbReference type="FunCoup" id="Q5BGS2">
        <property type="interactions" value="15"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CBF89865">
        <property type="protein sequence ID" value="CBF89865"/>
        <property type="gene ID" value="ANIA_00258"/>
    </dbReference>
    <dbReference type="KEGG" id="ani:ANIA_00258"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN0258"/>
    <dbReference type="eggNOG" id="ENOG502RZZQ">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="OrthoDB" id="430293at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="C:mitochondrion"/>
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        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="Probable endonuclease lcl3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SNase_OB-fold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016071">
        <property type="entry name" value="Staphylococal_nuclease_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12302">
        <property type="entry name" value="EBNA2 BINDING PROTEIN P100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12302:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00565">
        <property type="entry name" value="SNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00318">
        <property type="entry name" value="SNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50199">
        <property type="entry name" value="Staphylococcal nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50830">
        <property type="entry name" value="TNASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0106">Calcium</keyword>
    <keyword id="KW-0255">Endonuclease</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-0540">Nuclease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000408660" description="Probable endonuclease lcl3">
        <location>
            <begin position="1"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="TNase-like" evidence="3">
        <location>
            <begin position="89"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="188"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="280" mass="32598" checksum="D1289B0DABF1BE71" modified="2005-04-26" version="1">MRWPPWSSKTQEPTIADDKQQNCTSLLPVTTNQTDKAAILDWAAFTELRTLIPTLILTTAILSAARFHRSYLRRFPDAPSIDAAYFRRRSIYGKVTSVGDGDNFRIFHTPGGRLAGWELLPWKRIPKGKKELRDNTIHVRLAGIDAPELAHFGRPEQPYAREAHEWLTSYLLSRRVRAYLHRPDQYQRVVATVYVRRVLDFPIPFRRRDVSYEMLRRGLATVYEAKSGAEFGGDAIEAKYRNAEWWAKLKGNGMWKGFRRNKEFESPREYKTRVGLEEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BGZ7</accession>
    <accession>C8VUY0</accession>
    <name>Q5BGZ7_EMENI</name>
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        <submittedName>
            <fullName evidence="2">Molybdopterin binding domain protein (AFU_orthologue AFUA_5G11210)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_00183</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF90022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_657787.1">
        <property type="nucleotide sequence ID" value="XM_652695.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BGZ7"/>
    <dbReference type="FunCoup" id="Q5BGZ7">
        <property type="interactions" value="17"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5BGZ7"/>
    <dbReference type="GeneID" id="2875953"/>
    <dbReference type="KEGG" id="ani:ANIA_00183"/>
    <dbReference type="eggNOG" id="KOG2644">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030805_0_0_1"/>
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    <dbReference type="OMA" id="MARMPRG"/>
    <dbReference type="OrthoDB" id="448496at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047884">
        <property type="term" value="F:FAD diphosphatase activity"/>
        <property type="evidence" value="ECO:0000318"/>
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    <dbReference type="GO" id="GO:0042726">
        <property type="term" value="P:flavin-containing compound metabolic process"/>
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    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="entry name" value="MoaB/Mog-like domain"/>
        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="entry name" value="MOLYBDOPTERIN BINDING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G11210)"/>
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        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Molybdenum cofactor biosynthesis proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MoaB/Mog" evidence="1">
        <location>
            <begin position="1"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CBF90022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="309" mass="34576" checksum="2AA606D6763D5CE5" modified="2005-04-26" version="1">MKYSVGRAGQKLIGQTVDTNSAFFARYCFSLGIQLKRIEVIADEEEEIIEAVRRMSKNYDFVVTSGGIGPTHDDITYSSIARAFNLPLKLHEAAFERMKKLTKPHALTPDFSWDTPSPALTARLRMVELPFDASLPAESQAIFVSDDMWVPIAIVNGNVHILPGVPRLFERLLEHLRPSLLPRLVNPEGKGIYRYLFSTPLPESAVAPYLTDLATRTAARGVKVGSYPRWQKKRNTVTLVGTDKEFLDSLVAEVEENVQGKKVSAEDELDSDTEEKSLTMRYIFPPHLIIWDAIGLAVVILDLEGFSDI</sequence>
</entry>
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            <fullName evidence="1">Uncharacterized protein</fullName>
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        <name evidence="1" type="ORF">ANIA_11519</name>
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        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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            <taxon>Aspergillus subgen. Nidulantes</taxon>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF70829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3435065_0_0_1"/>
    <dbReference type="InParanoid" id="C8V0A8"/>
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        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF70829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="14" mass="1755" checksum="000716F72B9A9254" modified="2009-11-03" version="1">MPLYRNNYSVRVQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>C8V2J9</accession>
    <name>C8V2J9_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
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        <name evidence="3" type="ORF">ANIA_10773</name>
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        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
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            <taxon>Eurotiales</taxon>
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        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
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                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
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            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF70173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467004.1">
        <property type="nucleotide sequence ID" value="XM_050611949.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V2J9"/>
    <dbReference type="GeneID" id="74896594"/>
    <dbReference type="KEGG" id="ani:ANIA_10773"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN10773"/>
    <dbReference type="HOGENOM" id="CLU_1917045_0_0_1"/>
    <dbReference type="InParanoid" id="C8V2J9"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="28"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF70173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="132" mass="14119" checksum="569A58A971F8B8A1" modified="2009-11-03" version="1">MSSSDSNLPDFEHFLSDSSTDSSSSHSFPTAVIVLLPLITGVVLMAGIWCFAVKRGARNRARTLAKEQEQEQQSNPHGSGAGAGETLIHMQQIPPVVVRPGERHGVGDGVRNEVEDAPPPYSVAVQSADRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>C8V4C8</accession>
    <name>C8V4C8_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ser/Thr protein phosphatase family protein (AFU_orthologue AFUA_1G06000)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_10532</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF74485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467333.1">
        <property type="nucleotide sequence ID" value="XM_050611291.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V4C8"/>
    <dbReference type="GeneID" id="74896461"/>
    <dbReference type="KEGG" id="ani:ANIA_10532"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN10532"/>
    <dbReference type="eggNOG" id="KOG3947">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041441_0_0_1"/>
    <dbReference type="InParanoid" id="C8V4C8"/>
    <dbReference type="OMA" id="HIHDGRG"/>
    <dbReference type="OrthoDB" id="630188at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07379">
        <property type="entry name" value="MPP_239FB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051693">
        <property type="entry name" value="UPF0046_metallophosphoest"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12905">
        <property type="entry name" value="METALLOPHOSPHOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12905:SF16">
        <property type="entry name" value="SER_THR PROTEIN PHOSPHATASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_1G06000)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="2">
        <location>
            <begin position="6"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF74485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="385" mass="42212" checksum="1ED0D2BA204446C7" modified="2009-11-03" version="1">MRRKTRFVCVSDTHGYTPSEAGFRLPAGDVLIHAGDLTNQGSSSELRKTMNWIATADYEIKIVICGNHDITLDAPFYSQNSTKFHNKHRQDPEECLKTITTASSSIVFLQHQSALVRLRKAGGPNTVFKVFGSPYSQSDGEWAFLYEPDGAEELWRDIPLDADVVVTHTPPRFACDYDNVSTSSEADKRMGCPALGERLRIVRPCLAVCGHVHEGRGYKRVHWGASTAASATNEGDEGGSKRVRDQVTQGTLPSQGSKKQCLVDLTGKRAPRLDNVGFGLSRAGSLFPSLDSPDVVILPHQRPGIGYGQTADVRSSESDTEAKVGVEVEYTGAEHHRSHKRETCIVNAAIMATSWPHHGGRKFHPGPIVVDLELPVWTNYDGSFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2025-10-08" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>C8V4J1</accession>
    <name>C8V4J1_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ANIA_07893</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF73471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_681162.2">
        <property type="nucleotide sequence ID" value="XM_676070.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V4J1"/>
    <dbReference type="GeneID" id="2869178"/>
    <dbReference type="KEGG" id="ani:ANIA_07893"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN7893"/>
    <dbReference type="eggNOG" id="KOG0143">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010119_6_3_1"/>
    <dbReference type="InParanoid" id="C8V4J1"/>
    <dbReference type="OMA" id="LPKEWNC"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044283">
        <property type="term" value="P:small molecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.330:FF:000047">
        <property type="entry name" value="Similar to oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="3">
        <location>
            <begin position="185"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBF73471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="326" mass="36671" checksum="4A68CF85FD68D5C8" modified="2009-11-03" version="1">MGSVETIPTVDISAWLDPSSAEEDRQNVVNAMRHACTTYGFLSLVGHGVSLEEQKQAMDCAKLFFTLSEEEKMDVWIGKSKGRSFRGYEPPGIQVHQEGLLPDTKECFIIGHEVPEDHPDSGTFSTGPNLWPKSLPEDQFRIPIMKYQARMVQLVKVLLKILARGLPSEWNCPPDALDALAENEPSIPMRLLHYAPQPVRDERQFGVGDHTDFGCITILLQEMGTEGLEVWYPPTETWIPVPPQENAYVINIGDMIQKFTGGYYRSARHRVITFTEKHRYSVPFFLNGQLKLKCTALDGSGVETIVGEHIRGRLIETMGKTGEKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>C8V4L2</accession>
    <name>C8V4L2_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Amidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ANIA_04195</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the amidase family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF74509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467339.1">
        <property type="nucleotide sequence ID" value="XM_050611299.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V4L2"/>
    <dbReference type="FunCoup" id="C8V4L2">
        <property type="interactions" value="48"/>
    </dbReference>
    <dbReference type="STRING" id="227321.C8V4L2"/>
    <dbReference type="GeneID" id="2873618"/>
    <dbReference type="KEGG" id="ani:ANIA_04195"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN4195"/>
    <dbReference type="eggNOG" id="KOG1212">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009600_9_2_1"/>
    <dbReference type="InParanoid" id="C8V4L2"/>
    <dbReference type="OMA" id="TANWESI"/>
    <dbReference type="OrthoDB" id="6428749at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043605">
        <property type="term" value="P:amide catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072:SF8">
        <property type="entry name" value="AMIDASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072">
        <property type="entry name" value="AMIDASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001221">
        <property type="entry name" value="Amidase_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="5">
        <location>
            <begin position="114"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="3">
        <location>
            <position position="170"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="3">
        <location>
            <position position="249"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="3">
        <location>
            <position position="273"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="270"/>
            <end position="273"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBF74509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="598" mass="66434" checksum="508A7A680378B50B" modified="2009-11-03" version="1">MAAKFRTLILTVALFVSALTLLDWTYDMWKIQEIFSSWPARWQQIASAKREANMAKIPREWILEPQVLEDGRSRNSIVGDYMDGLLDAKSRYVTDMDVPELVARMGDGTLTAVEVVKAFCKRAAYAHQLSNLLLEIRFNEAIERAQELDDYFNKHKKLIGPLHGIPLTLKDQFHIKGLDTSMGFIGWIGTFEGEMDTGKAKNVDSELVREFHVLGAVPIGKVIKAPETNNNILGYAFNPCNQNLSTGGSSGGEGAMQALRGSAFGIGTDIGGSVSMPASFQGVFSIKPSAGRISFKDAANTGKGQEVMPTVVGIMGRSIDTLQLILKSLLFLEPWLHDPYTLPIPWRSELEYKPQDELAYKPAFGFLANDGVLTPHPPISRAMEIVKEALQSKGHQLVDWDWPHNRETIDIHCSIARGDGCHDVYDAVHLSGEPFVPEITNLFPNGKPRAPLPLPEYEGIVRKMKDYRHRYLDYWISTAERTGDRPVEALLSPVTPYAGVLPGKFYPSTYTTSVNVLDYASVVIPVTLADKTIDVVSPNFTALNEVDQLNMEYYDPEKYHGAPAAVQLIGRRLDEERLLSLAKLVVEALNDYRSGYGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>C8V4R8</accession>
    <name>C8V4R8_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ANIA_03539</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF75932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467536.1">
        <property type="nucleotide sequence ID" value="XM_050611513.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V4R8"/>
    <dbReference type="STRING" id="227321.C8V4R8"/>
    <dbReference type="GeneID" id="2872956"/>
    <dbReference type="KEGG" id="ani:ANIA_03539"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN3539"/>
    <dbReference type="eggNOG" id="ENOG502SM9H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022205_1_0_1"/>
    <dbReference type="InParanoid" id="C8V4R8"/>
    <dbReference type="OMA" id="ERCHMVG"/>
    <dbReference type="OrthoDB" id="2117718at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF75932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="488" mass="55215" checksum="3E173D3BB7631857" modified="2009-11-03" version="1">MSTNDPMPQICLEASRKAGIPSLATSASYEDRVRSGNAFSSTFLRYLGGEHLLPYFLRFMCPHPVLVPDTFMANLKEFHVALTAALTNIVQRWVIDEEADLPSRMPLEPHEEDILRWIHKITEDKLFPAYDGRQGNWRPDFLLPANETGGFRVCEINARFTSNGLDLNARVNRAMDNSENKPPYLDVEGNPDHMMDRLKALFHPGWPLRFVHNREHNPMIEALMRDLGNMKPRLLTPDDLHLVADKTSPTGYRLQCVREPGSSADHDNETVEDIHQVALRLFLDELAALPPEMQRQLAFLSCNDIRSMLLIHDKRILGILLQELNDLVVKHNVLTSRQADLLRKGVVFTIIPGSKELDQLIDSYYKGKVSKKDFILKPIRSGRGEGILLGGDLSTVKWEAILSDMKSAALAPSRAQYIIQPFVEQLEADTFLDEEAGVQRTRRVGTYHSMHGQFVSLGVWRVGISKSRTINMTTGGAWKLGSMVRKMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>C8V514</accession>
    <name>C8V514_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Oxidoreductase 2-nitropropane dioxygenase family, putative (AFU_orthologue AFUA_2G17430)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ANIA_04120</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF74663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_661724.2">
        <property type="nucleotide sequence ID" value="XM_656632.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V514"/>
    <dbReference type="STRING" id="227321.C8V514"/>
    <dbReference type="GeneID" id="2873541"/>
    <dbReference type="KEGG" id="ani:ANIA_04120"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN4120"/>
    <dbReference type="eggNOG" id="ENOG502RHJM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038732_9_0_1"/>
    <dbReference type="InParanoid" id="C8V514"/>
    <dbReference type="OMA" id="FGWPEEY"/>
    <dbReference type="OrthoDB" id="2349068at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018580">
        <property type="term" value="F:nitronate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009410">
        <property type="term" value="P:response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd04730">
        <property type="entry name" value="NPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000288">
        <property type="entry name" value="Oxidoreductase, 2-nitropropane dioxygenase family, putative (AFU_orthologue AFUA_7G03850)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004136">
        <property type="entry name" value="NMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332:SF34">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE FAMILY, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03060">
        <property type="entry name" value="NMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBF74663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="380" mass="40391" checksum="54AF0AC9F74725A5" modified="2009-11-03" version="1">MSTSLSKLAAQFPWAAVPLIVSAPMRVMAGPKLAVAASTAGGLGFIGPGVKTANMLSDLEEASTLIKNSRLASLGPTLKTLPVGVGFQVWSDDLDTATHAVREFKPCVVWLFAPKEFTDLTIWSNTLRDVSPNSQIWIQVGTLSEVKRLLTMGTSTSTRDGPDAIVVQGSEAGGHGRASDGLGLVSLLPEAADAVAASQTPEIPLLAAGGIADTRGASAALCLGASGIVLGTRFLAATEARISSGYQHEILRADDGAVSTTRTLLYNHLRGITTWPEEYSPRTIINQSFVEYRAGTAFEELKKRHDEHLQLGDAGWGPNGRLATYAGASVGLIHEVKDAGDIVRDQGGREEDGSVYRLGETWCLRALYWRNNLPAFCSPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>C8V5G3</accession>
    <name>C8V5G3_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uridine nucleosidase Urh1, putative (AFU_orthologue AFUA_1G05530)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ANIA_04075</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IUNH family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF74757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_661679.2">
        <property type="nucleotide sequence ID" value="XM_656587.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V5G3"/>
    <dbReference type="STRING" id="227321.C8V5G3"/>
    <dbReference type="GeneID" id="2873500"/>
    <dbReference type="KEGG" id="ani:ANIA_04075"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN4075"/>
    <dbReference type="eggNOG" id="KOG2938">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1652134_0_0_1"/>
    <dbReference type="InParanoid" id="C8V5G3"/>
    <dbReference type="OMA" id="DVAKFWH"/>
    <dbReference type="OrthoDB" id="432381at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016799">
        <property type="term" value="F:hydrolase activity, hydrolyzing N-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.245.10">
        <property type="entry name" value="Ribonucleoside hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001910">
        <property type="entry name" value="Inosine/uridine_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023186">
        <property type="entry name" value="IUNH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036452">
        <property type="entry name" value="Ribo_hydro-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12304">
        <property type="entry name" value="INOSINE-URIDINE PREFERRING NUCLEOSIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12304:SF4">
        <property type="entry name" value="URIDINE NUCLEOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01156">
        <property type="entry name" value="IU_nuc_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53590">
        <property type="entry name" value="Nucleoside hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inosine/uridine-preferring nucleoside hydrolase" evidence="4">
        <location>
            <begin position="2"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBF74757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="160" mass="17421" checksum="94F731A76F90C813" modified="2009-11-03" version="1">MTLDLTHQVLASRDVQTRILHGDGDPSTAPTVLRQMLYELLLFFASTYEAEFGLTTGPPLHDPLAVAAVISTLNPDFARRYPEQALKFDDRNGERFAVTVVTDGLHGTDVAMVGQLGRSVVSSHATGVTIPRGVDIDAFWNIIVDCIRRADELNSARTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>C8V9T1</accession>
    <name>C8V9T1_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Mitogen-activated protein kinase kinae kinase bck1</fullName>
            <ecNumber evidence="1">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">ANIA_04887</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:17990"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:46609"/>
        </physiologicalReaction>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="1"/>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF76548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467595.1">
        <property type="nucleotide sequence ID" value="XM_050611581.1"/>
    </dbReference>
    <dbReference type="STRING" id="227321.C8V9T1"/>
    <dbReference type="GeneID" id="2872688"/>
    <dbReference type="KEGG" id="ani:ANIA_04887"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN4887"/>
    <dbReference type="eggNOG" id="KOG0198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000961_1_0_1"/>
    <dbReference type="InParanoid" id="C8V9T1"/>
    <dbReference type="OMA" id="MQISPKP"/>
    <dbReference type="OrthoDB" id="266718at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000165">
        <property type="term" value="P:MAPK cascade"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd06629">
        <property type="entry name" value="STKc_Bck1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000182">
        <property type="entry name" value="MAP kinase kinase kinase mkh1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050538">
        <property type="entry name" value="MAP_kinase_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016">
        <property type="entry name" value="MAP KINASE KINASE KINASE SSK2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016:SF48">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE BCK1_SLK1_SSP31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="1266"/>
            <end position="1535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
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    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
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    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
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    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="557"/>
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    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="709"/>
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    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1105"/>
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    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1137"/>
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    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="27"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="57"/>
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    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="211"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="527"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="561"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
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            <begin position="806"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="10">
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            <begin position="917"/>
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        <location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1237"/>
            <end position="1260"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="1295"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00068103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CBF76548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="1558" mass="169274" checksum="F423FF003E7CB82D" modified="2009-11-03" version="1">MDGQRQQPYVPAPPPSASQPSQAHIMPLPPPPPRYPPAQPQNVMPPPPPGPPPGSAYGTSKLTNPQLQSQSTLGWSNWGGRGIPQYLPPPPPPPMTHANQSSFARPSAVQNNNATSATYVPQPGTFGPGVGIPPFDVPSHSYDAPNTMVASERPRPPPNAPYGHGTSNASAYQLDGTIPSTPLTHTAPFSHETSHDVPSSAVPTGSPFKSVPQSASQANDLTKSSSHRHNNSNTTVGGMSASEAAVQWPLDRVLLWLAKNGFSHEWQETFKTLEIEGADFLELGHGQNGRPNLGKMHTVVYPQLAKECEANGTAFDLTRERDEGKRMRKLIRLIHDDAGPDNGGTFNKQHDFDDGHGSVPDEGPEFSPNINNVAQAPGSPSLNATNVSNSPNLKAPKYSHKPRSFTTPGSISHDSTTAELAMTEGSSTMLPRSDFSRNVLGTIGIDHQRKSPSMSSDNGVFAIPPHRPHEGSPKSGSPAAQHATLYAAPVSSATDLNAKYDARFGHNRVNSGERRYYETLKHDGSRPSPQTTQTAGDNASSYPKDHRMGFLNFFKKKSARNSDPNNPSPDDNTPDSPIYSKYHFNSSDVSVNERPLSASLSDYERMMMVRTKPAHRGKRFIFATMDGWNYRLIDTTDIDSVEKLRASICQNLGIYDWPDAQIFLTEPGQLEHDEPLNDTFLTLCQRSKSDSIGSLKLFVKTPHNVAGLGVSMPDRSAVSPTSAIPRKPLDGEAASRLSPLKPSSPQQLKPPASRLPLRDIQNSAAGTSPVDGEPDGSLQDQERKPQKSYRPTPAPLPRPDAYSETGYRRKEVINFDKPRISPYEDKKSEVLVPFRKPPSAPQESNTLSKVNSLRKKDGDRPRPHRSNQPPGIKEMMADMGMMSSLIGKPSSPNSGNTTATEDAHSSIDSAVDKSSQSTPPLTNTSYSPTTTATTTTTTTTASSSLSRSASQKRKSVGPEFDFEETQVSFQRSPALEEDSDDDSDDGLFAIPLANTKNSVKPGSPDTQARPRKPSLTVDTEAKPRTGLSVSFKSPSATRETFASSGGDASNSTAPYFIASNSPEEEKTPIRRNSLRNSFATGDVWASRPPVEGVIDQLDDFFPDIDLDAPYLDEQGTSPPSSPASKVAIDNELNRKDKQENSHHGMQPPPAPEDNTLGSSEPTMTSHGQGIVARRNVSRSGGGLTRMKSIREVAKGANQATRQRSVAASSGNKRSGDVHRRKSTKMFGAKIMQISPRRGSQLSQLDPIPQNSISSSSKPQRQPTFRIIRGQLIGKGTYGRVYLGMNADNGEVLAVKQVEINPRLAGQDTDKIKEMVAALDQEIDTMQHLEHPNIVQYLGCERGELSISIYLEYISGGSIGSCLRKHGKFEESVVKSLTRQTLEGLSYLHNQGILHRDLKADNILLDLDGTCKISDFGISKKSNDIYGNDSSNSMQGSVFWMAPEVIQSQGQGYSAKVDIWSLGCVVLEMFAGRRPWSKEEAIGAIFKLGSLSQAPPIPDDVSMNVTPAALAFMWDCFTVDTSERPTAQTLLTHPFCEPDPKYNFLDTELYAKIRPVLEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>C8VBC3</accession>
    <name>C8VBC3_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ANIA_10942</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat AIP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF79402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467959.1">
        <property type="nucleotide sequence ID" value="XM_050611993.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VBC3"/>
    <dbReference type="FunCoup" id="C8VBC3">
        <property type="interactions" value="755"/>
    </dbReference>
    <dbReference type="STRING" id="227321.C8VBC3"/>
    <dbReference type="GeneID" id="74896690"/>
    <dbReference type="KEGG" id="ani:ANIA_10942"/>
    <dbReference type="eggNOG" id="KOG0318">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015246_1_0_1"/>
    <dbReference type="InParanoid" id="C8VBC3"/>
    <dbReference type="OMA" id="FYQGPPF"/>
    <dbReference type="OrthoDB" id="2306at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030864">
        <property type="term" value="C:cortical actin cytoskeleton"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003786">
        <property type="term" value="F:actin lateral binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030042">
        <property type="term" value="P:actin filament depolymerization"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051014">
        <property type="term" value="P:actin filament severing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051016">
        <property type="term" value="P:barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032466">
        <property type="term" value="P:negative regulation of cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000102">
        <property type="entry name" value="Actin-interacting protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000167">
        <property type="entry name" value="Actin-interacting protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19856:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19856">
        <property type="entry name" value="WD-REPEATCONTAINING PROTEIN WDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="49"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="180"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="224"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="317"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="527"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="570"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="7"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBF79402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="607" mass="64336" checksum="996ED11B1E5BCE81" modified="2009-11-03" version="1">MAIWAASPSTTRGQPTQLSSDAKGERLAYASNKSIFLRSIDDPAVARQYTEHKVQTTVARFAPSGFYVASGDASGVVRVWDCVGEGITKGEYSIVNGRINDLAWDGDSQRIIAVGDGKQRYGHCITWDSGNTVGEISGHTQAINAVSIRQQRPLRAAAAGDDKNVVFYHGAPFKFNTGIRDKHTNYIYGVGFSPDGSTLVSVGADRKIWLYDGKSGEVKGQIGEGEHKGSIFAVSWSKDSRKFVTASADKTVKIWDAEAGKVTQNWNIGGEGNQNFLNQQVGVVWPPGRSDNLLISLSLSGDLNYLVEGTPEPRQIIQGHQKNITSLTAFESSSGEETLWTGSFDGRVCGWDVPTGKAETIEGDGSSSYIAGLTSTQEGAGRLYSVAWDDTIRSLDIGAKTYTGSSSKLSGQPKGIAGGGTTVLVANAESIEIHRDGQKVGDFKPNFSVTAVAAHGSIAAIGGDDSTVQICDIAGTSLTPKHDFKASRDVVSAMAFSPDGSKLAIGDSRGRVLVYKVADGSLVNDRWTAHTSRITSIAWNDNGAHIVSGALDTNIFVWSLTNPGDWLQVSNAHKEGVNGVAWIAGGSKVASAGADAAVKVWKVEGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>C8VCB4</accession>
    <name>C8VCB4_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ANIA_10872</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF79313.1"/>
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        <property type="nucleotide sequence ID" value="XM_050611972.1"/>
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    <dbReference type="AlphaFoldDB" id="C8VCB4"/>
    <dbReference type="STRING" id="227321.C8VCB4"/>
    <dbReference type="GeneID" id="2870188"/>
    <dbReference type="KEGG" id="ani:ANIA_10872"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN10872"/>
    <dbReference type="eggNOG" id="ENOG502QQ04">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037759_0_0_1"/>
    <dbReference type="InParanoid" id="C8VCB4"/>
    <dbReference type="OMA" id="FNVRILS"/>
    <dbReference type="OrthoDB" id="5345494at2759"/>
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        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF79313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="579" mass="64614" checksum="16FE2B1EFF97C6FE" modified="2009-11-03" version="1">MSEALWSVLVTSIDPDNKKNMSAVLQSTINLLETELVKARAALQEIQPNAGLMINRGEELAVGAVAAYRQNLISFAPDFFYGARRLTPKELGLVPVVREIELSDEEETVKERPEPVVERKPTSIEDVLGNGLILDHLVPYLTPGTLLALSATSRFVRSLIMETPYVFRHLDLSHCRGARLTDQPPIDRGGQTWRAERIDESLTEDEFYSGPLRGIFANLERSSIMSDVRTLILDGLPVPADLVSDLVLSDRFNLSLLSIRECRHLNERKLMQVLNYAVRPTRPAGTPRIKGIYYFTPTDRPRAAVRSKYKDWWSSQCVSQRTLGDVPPTQNQKEKQRQNVWYNSSGKLLKHRIEEGWAETLQKCEGIIAFDAVLCRGPRHNVDLCATVSPSTEDAQPGKRLLGPAIATIALGPMGCDGCHTSEEGPAIWGQSPAEHFPLLTPPPFHSSSLAAAKRPALVFGEHPVLIARCADCLADRWCHRCNKWFCNSCLPRPERVRSKLSPHQTAVRGPRAGNEGFGPGVSKDCWECGPTCAACKLDCQRNCQNCQGDYCIEHNEGCSSTMCDWCNTSTRHRMRQLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>C8VCW7</accession>
    <name>C8VCW7_EMENI</name>
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        <recommendedName>
            <fullName evidence="4">Geranylgeranyl pyrophosphate synthetase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_07245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF78778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467869.1">
        <property type="nucleotide sequence ID" value="XM_050611896.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VCW7"/>
    <dbReference type="STRING" id="227321.C8VCW7"/>
    <dbReference type="GeneID" id="2870134"/>
    <dbReference type="KEGG" id="ani:ANIA_07245"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN7245"/>
    <dbReference type="eggNOG" id="ENOG502QRQN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030046_1_0_1"/>
    <dbReference type="InParanoid" id="C8VCW7"/>
    <dbReference type="OMA" id="IVSVMKM"/>
    <dbReference type="OrthoDB" id="5393654at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35179">
        <property type="entry name" value="PROTEIN CBG02620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35179:SF2">
        <property type="entry name" value="START DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="421"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF78778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="471" mass="52915" checksum="130698F2C07E8132" modified="2009-11-03" version="1">MTEPRRETIRGRGRGSWRRSRKSRADAEPSAPAVGPLLSTITREDLDSNITSSSGKEFSMITDCRLVGSYNWLNRKSPTILVPGAPPEWTPTGTSERLPQDKGTYFRDQNSARYAAHVFQPAANSILNQDPDFDFTQIDIVACNSTLGNLRRFIAEPDKQFRFIVEAVGSTVFFVRRENSPTQALSNVVGFGHTFPEANTTWGSDVKGSESHQRILQYRFAGLSCLVRYGGDGYLPQLYQPHGPRREPAATAPDDLLASFNQVSVSTVSPEGEQALRVESGGELVPQSAMFDLKTRSATKQYSNILRDELPRLWISQIPNFVVGFHTDGEFHDVRVEDVREEVRKWEERNEVQLRKLSTLMKLLIEFADGQPNRRFEVVYNGTDGNGELELREVGDEVNCCLSDVMKRRWAAGYLDGRGKEKKDEREEVDDAGQSKHIEREDSEWSGESESEKDFTACSASTCGYCGHCAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>C8VDW1</accession>
    <name>C8VDW1_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_11024</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
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        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF80205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468057.1">
        <property type="nucleotide sequence ID" value="XM_050612103.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VDW1"/>
    <dbReference type="STRING" id="227321.C8VDW1"/>
    <dbReference type="GeneID" id="74896737"/>
    <dbReference type="KEGG" id="ani:ANIA_11024"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN11024"/>
    <dbReference type="HOGENOM" id="CLU_2277456_0_0_1"/>
    <dbReference type="InParanoid" id="C8VDW1"/>
    <dbReference type="OrthoDB" id="37659at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF135">
        <property type="entry name" value="BLL7886 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF80205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="102" mass="11241" checksum="A2582FFC7013C937" modified="2009-11-03" version="1">MRLILYDAVTDADWDRFMAVNLTAPVRRMEEVIREMRNQKSGVILNMASPAGMSGAAAGVAYTASKHGLIGATKNVAWRFKGENIRQCAVPGSYWKSHNPCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>C8VED0</accession>
    <name>C8VED0_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ANIA_11078</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 88 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF80520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_681694.2">
        <property type="nucleotide sequence ID" value="XM_676602.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VED0"/>
    <dbReference type="GeneID" id="2868699"/>
    <dbReference type="KEGG" id="ani:ANIA_11078"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN11078"/>
    <dbReference type="eggNOG" id="ENOG502S0YB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027158_2_0_1"/>
    <dbReference type="InParanoid" id="C8VED0"/>
    <dbReference type="OMA" id="REPEFWT"/>
    <dbReference type="OrthoDB" id="2317065at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052757">
        <property type="term" value="F:chondroitin hydrolase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000048">
        <property type="entry name" value="Unsaturated chondroitin disaccharide hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052369">
        <property type="entry name" value="UG_Glycosaminoglycan_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36845">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G05090)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36845:SF1">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G05090)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBF80520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="522" mass="57340" checksum="3142AACEF4FA4A44" modified="2009-11-03" version="1">MNGHSISCTSSTSSSPDGLSPLPKKRKADSITSLSDGQTDSDETPVTPQILRDQAPQYDVPDLFDENILAKVFRTASASLNDPKVFTKPTGVPIGYPEIVPQDGPSFGQYEFRDPEFWTCGFFPGSLYALLERSIKYPHCVSIRSSIKIQDVRTQLRSLSKAWSKSLHSMAFRTDTHDIGFIVMPALKRDWELSGNEQSLRSITQAAWSLATRYVPTAGAIRSWDCLVKKEITVTDQSENVLVIVDSLCNLDLLFYASAHTGDDSFAKLAEIHARTLLRTHLREENGIVVPKGGYQGQLYSTCHVANIDPANGSLKWRWTAQGYSNDSTWSRGQAWAILGYAQTYMWTKDTSFLDAACGTAEYFLHRLETAPLCVEIPLDVYSPCLSTAGNKKRRSTKGRHVPLWDFDAPVDPSSPLRDSSAGLIAANGMLVLFQALLSTGQDKLARRFLDAAVEIVGDTINLCLALEKAQLVGEGSNISVEDSTPGYTVSQIELQSPVSHTQVSIRVGDVGPPCSRYQCPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>C8VEP5</accession>
    <name>C8VEP5_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Zn(II)2Cys6 transcription factor (Eurofung)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ANIA_08529</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF80735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468112.1">
        <property type="nucleotide sequence ID" value="XM_050612164.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VEP5"/>
    <dbReference type="GeneID" id="2868619"/>
    <dbReference type="KEGG" id="ani:ANIA_08529"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN8529"/>
    <dbReference type="eggNOG" id="ENOG502QRM1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024934_5_2_1"/>
    <dbReference type="InParanoid" id="C8VEP5"/>
    <dbReference type="OMA" id="DLVLMHR"/>
    <dbReference type="OrthoDB" id="5350673at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053157">
        <property type="entry name" value="Sterol_Uptake_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784">
        <property type="entry name" value="STEROL UPTAKE CONTROL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784:SF5">
        <property type="entry name" value="STEROL UPTAKE CONTROL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="19"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="372"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBF80735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="391" mass="43844" checksum="D20FF0EE528E7D6A" modified="2009-11-03" version="1">MPTGVQKPTRRFHKKSRTGCTQCRSRRIKCDETHPVCRNCQRAGMVCHYTVQSSPNTGAAQSIPGPLSLPESRTSFDMLDLTLMHHYTAVTSVSLFGEEQKELWQAEVPTMACSSPLLMHGLLATAALHMAFFCKDSPSAFINRALHHHSLGLELFNAEISTLSAENGKSPLLFTFGLILVIWAYASPTLPNAVTTTADESDLDTLLSSLDLVRGNKIIFEISAEIILSQPIGRFLKPLEEFARPRALPQPIQAALTDLRKNVDDFVESMAIDQLERYLLDTVSTSANDMRRPLGWPALAEAPFWERVRKHRPAALLIFMHYAIILAYYEPRTWWMQGWSERLVGAVNHVLVKQDKNRPDWGFCAGRPERNRRTAAVKPSSDSVAPRLILP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>C8VF09</accession>
    <name>C8VF09_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DSBA-like thioredoxin domain protein (AFU_orthologue AFUA_7G06250)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_10641</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF80947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468147.1">
        <property type="nucleotide sequence ID" value="XM_050612201.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VF09"/>
    <dbReference type="GeneID" id="2871434"/>
    <dbReference type="KEGG" id="ani:ANIA_10641"/>
    <dbReference type="eggNOG" id="ENOG502QTH7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069253_0_1_1"/>
    <dbReference type="InParanoid" id="C8VF09"/>
    <dbReference type="OMA" id="QKYAISG"/>
    <dbReference type="OrthoDB" id="1930760at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03024">
        <property type="entry name" value="DsbA_FrnE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001853">
        <property type="entry name" value="DSBA-like_thioredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13887">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE KAPPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13887:SF41">
        <property type="entry name" value="THIOREDOXIN SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01323">
        <property type="entry name" value="DSBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DSBA-like thioredoxin" evidence="1">
        <location>
            <begin position="6"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF80947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="202" mass="22427" checksum="FFBADD1B486A10F9" modified="2009-11-03" version="1">MTNFNIQIISDSVCPWCYVGYRRLSRAITTHKLTNPLDTFTITWSPFYLNASSPGYPGVNKRQFYENKFGAARTGAIFERLAAVGEGEGIKFRKIENGVIGGLQTRVVERLFRAYFEEEKNITERAVLVEAAVGGGLDKSEVEGFLDSDVGGVEVDRDAEGARRQFVTGVPYFMVQGQYAIEGADEPETFLEVFGKIKADGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>C8VFR5</accession>
    <name>C8VFR5_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Amino acid transporter (Eurofung)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ANIA_05678</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF81419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_663282.2">
        <property type="nucleotide sequence ID" value="XM_658190.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VFR5"/>
    <dbReference type="FunCoup" id="C8VFR5">
        <property type="interactions" value="220"/>
    </dbReference>
    <dbReference type="STRING" id="227321.C8VFR5"/>
    <dbReference type="GeneID" id="2871969"/>
    <dbReference type="KEGG" id="ani:ANIA_05678"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN5678"/>
    <dbReference type="eggNOG" id="KOG1286">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007946_12_0_1"/>
    <dbReference type="InParanoid" id="C8VFR5"/>
    <dbReference type="OMA" id="AITVGYW"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003333">
        <property type="term" value="P:amino acid transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000017">
        <property type="entry name" value="Amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004762">
        <property type="entry name" value="Amino_acid_permease_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00913">
        <property type="entry name" value="2A0310"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF1">
        <property type="entry name" value="GENERAL AMINO-ACID PERMEASE GAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="113"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="195"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="308"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="366"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="409"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="439"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="481"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="522"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="10">
        <location>
            <begin position="85"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="14"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CBF81419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="588" mass="64425" checksum="03123D1A8CAB1107" modified="2009-11-03" version="1">MSTMDKDFLKGNPERSTSSDSTPVYGESTSRRASLGQRVLGSFQRDPNAHVTAFASFSDGKTYDIENATEKAANSPLHRSLRGRHLQMIAIGGSIGTGLFVSSGRVLATGGPASLLIAYALIGCMLYCAVHALGEMAVIFPVAGSFAHYSTRFIDPAWGFAMGWNYALQWLAILPLEIVAAAITVDYWESNISSAVWVALFWAAIVSINLFGVKGYGEAEFVFSSIKVIAVIAFIILGVILNCAGGQNGSYIGVKYWHDPGAFHHGFKGLCDVFVNAGFAFAGTELVGLAAAETANPRKSLPTAIKQVFWRITLFYIVSLTLVGLLIPYTEPRLINGTSTVDTKASPFVIAIKNAGIEVLDSVMNVVIMIAVLSVGNSAVYGSSRTLAALAEQQQAPRFLGYIDRKGRPLWAICIASAMGLLGFLAATDKQEVAFEWMIAISGLSSIFTWGSICLAHIRFRRAWKVQGNSLHDLAFRSQPGIIGSWIGFAFNCLVLVAQFWVGFAPIDYETMSASMLARNFFSKYLAAPVVLLFYIPYKLRFKTKILRAKDMDLRTGRRELNIQWLMKEERAQQAAWPAWKKIYKFFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>C8VFW2</accession>
    <name>C8VFW2_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Potassium ion transporter (Eurofung)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">ANIA_05636</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TrkH potassium transport family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF81506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468222.1">
        <property type="nucleotide sequence ID" value="XM_050612281.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VFW2"/>
    <dbReference type="STRING" id="227321.C8VFW2"/>
    <dbReference type="GeneID" id="2871928"/>
    <dbReference type="KEGG" id="ani:ANIA_05636"/>
    <dbReference type="eggNOG" id="KOG1341">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005947_5_0_1"/>
    <dbReference type="InParanoid" id="C8VFW2"/>
    <dbReference type="OMA" id="YLDECGQ"/>
    <dbReference type="OrthoDB" id="9999863at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140107">
        <property type="term" value="F:high-affinity potassium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003445">
        <property type="entry name" value="Cat_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004773">
        <property type="entry name" value="K/Na_transp_Trk1/HKT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015958">
        <property type="entry name" value="Trk1_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051143">
        <property type="entry name" value="TrkH_K-transport"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00934">
        <property type="entry name" value="2a38euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31064:SF5">
        <property type="entry name" value="POTASSIUM ION TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31064">
        <property type="entry name" value="POTASSIUM TRANSPORT PROTEIN DDB_G0292412-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02386">
        <property type="entry name" value="TrkH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002450">
        <property type="entry name" value="K+_transpter_TRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0630">Potassium</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002992188" evidence="12">
        <location>
            <begin position="26"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="292"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="364"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="428"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="490"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="576"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="114"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="114"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="150"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CBF81506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="673" mass="75310" checksum="2F72874CCA7348D6" modified="2009-11-03" version="1">MWKISINFILLHWLAVFYPYGNVSAIDSYFFGVSSSTESGLNPYANLGLYIWVVDLKDLKTYQQLFLYFIPIVSNLGFINILIVVIRLHWFEKRLKEIAPSVLRQRPEVSAIKTTQFDQEAQSVSNAEPTKPAGNQGVQENKASEKVRETSIQAGASTKGSLEESQPAVSFSYTSKALYIPPPRDRDRGCPIIEIDHTPNKDDSANDTDIAVGDVRARRRLSDASIHQVGVLTFAQTSRKHRDTGTAVSLSKDMSLPGLSSQATLGRNSQFLNLTTRDREHLGGVEYRSLRLLLKIAIGYFLGIHLIGAVCLAAWIQNADMKYRNYLDECALNPVWWAFYSAQTMSNNLGLTLTPDSMVSFQEATFPLFVMSFLAYAGNTLYPCFLRLVIWTMFKLVPGESSLREPLNFLLKYPRRCYVLLFRSRPTWALAGIIFILNFVDILLILLLDLDNPAVNSVPAGPRVIAAIFQAASARHTGTASFSLADVNPAVQFSLLVMMYIAVYPIAITVRASNTYEEKSLGIYSPEPETDENGKGYILTHMRNQLSFDLWYIFLGIFCICVAESKRIMNPAEPGFSVFAIFFEAVSAYGNVGLSLGYAGVSTSFSAQFSTFSKLVVCALMIRGRHRGMPSQLDRAVLLPSDRLVEDDSVTMYSSKGLWLEPRSLKVRRYHTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>C8VHU1</accession>
    <name>C8VHU1_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ANIA_10392</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF82892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468399.1">
        <property type="nucleotide sequence ID" value="XM_050612482.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VHU1"/>
    <dbReference type="GeneID" id="74896380"/>
    <dbReference type="KEGG" id="ani:ANIA_10392"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN10392"/>
    <dbReference type="eggNOG" id="KOG1231">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018354_1_2_1"/>
    <dbReference type="InParanoid" id="C8VHU1"/>
    <dbReference type="OMA" id="AKAACAY"/>
    <dbReference type="OrthoDB" id="2151789at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF22">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="5">
        <location>
            <begin position="64"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBF82892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="497" mass="54224" checksum="95C55C9126D4B705" modified="2009-11-03" version="1">MASYVPYAVGVLGVWAAITFTQHPFYRHHDTCDNLASILDNRVFASSSAEYKESVSSYFSFQEQNLQPACVVQPTTAQELSAAIVLLARDYHDHGQQFAIRSGGHMIPGGAANIHGGVTIDLRAMNDIDLSSDRSKVQIGTGATWGQVYKVLDPLNITVTGGRAASIGVGGYLTGGGLSALGPATGWGCDNVLEVEVVLASGEIVQASRTSYPDLFVALRGGSNNFGVVTKFTMAAHPSNGIWGGFMAYPESEVPRQIRAYSDFMQSRSVDSLADPIQSYGWTSNRRVLFGTNILLYAKPHPHPPVLQSFINNTTTLHSTLRITTMADFAEEEDRYQIPGFYYSTLYFTTTFAHDPSVYAPIVSEFNRSCHAVSAVENMNWYMSFQPSAALNGENSLGLDPRDERLNIIILVAFFPSPEDSTVVRNAANDLIRSIEEITRAAGVYRPFKYLNYADDSQDVIGGYGEQARAALQAASRKYDREGVFQSAVPGGYKLFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>C8VJL7</accession>
    <name>C8VJL7_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Zn(II)2Cys6 transcription factor (Eurofung)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ANIA_02782</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF84024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468543.1">
        <property type="nucleotide sequence ID" value="XM_050612645.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VJL7"/>
    <dbReference type="FunCoup" id="C8VJL7">
        <property type="interactions" value="241"/>
    </dbReference>
    <dbReference type="GeneID" id="2873898"/>
    <dbReference type="KEGG" id="ani:ANIA_02782"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN2782"/>
    <dbReference type="eggNOG" id="ENOG502QRM1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024934_2_0_1"/>
    <dbReference type="InParanoid" id="C8VJL7"/>
    <dbReference type="OMA" id="HARRPHK"/>
    <dbReference type="OrthoDB" id="416217at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052400">
        <property type="entry name" value="Zn2-C6_fungal_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47657">
        <property type="entry name" value="STEROL REGULATORY ELEMENT-BINDING PROTEIN ECM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47657:SF15">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00755">
        <property type="entry name" value="AFLATOXINBRP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="38"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="73"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBF84024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="437" mass="48318" checksum="6306E34045C1B0DE" modified="2009-11-03" version="1">MALSSPRAFQSTFKVTLPDRQVQTPYHARRAHKKSRNGCLVCKGRRVKCDERKPTCLRCENYGAACVYASSQATSSSSSSSPSSSRSSSILRSATASTSKSTPPNNTLTSLSISDMVNRVRDTLGNDLALAPRTIGNRDEALDLAVDSFRFFLTCSVNSISTPQIYQVMKREVVHVAFDNPYLMYTLLGCGVLHMNRVSPGNESRELGEAYFWQRAVQLYSAALQHPINQQNISGLISASILIGVTSLAPLKFEMQDSWVFTGRGSDLNWLAIQGGLACILKHAGQYVPGSIWGVPFSQSHEIESQLFRYEITKGREGLRPDLADLCGITDETDEQTSLYWAPIKLLSPFMELEVNAQIASQCTTWMGRLEPSFVNLCRERDPRALVIFAYWMGLMCSMSQESWRSSYTAILGVSGGCGGLYLDLLMINVDTGFNKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>C8VK64</accession>
    <name>C8VK64_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_09136</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF82477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468338.1">
        <property type="nucleotide sequence ID" value="XM_050612413.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VK64"/>
    <dbReference type="GeneID" id="2867964"/>
    <dbReference type="KEGG" id="ani:ANIA_09136"/>
    <dbReference type="HOGENOM" id="CLU_2793958_0_0_1"/>
    <dbReference type="InParanoid" id="C8VK64"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF82477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="68" mass="7902" checksum="7AE58B695374D97D" modified="2009-11-03" version="1">MAQSTKYRERKRKRSYAKNPVGVLTPSSRIHVMSSSELKFQTMQTRQTDTCSQRIETKQPSTRDGRNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>C8VL67</accession>
    <name>C8VL67_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidyl-tRNA hydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_10255</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
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    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF85964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468782.1">
        <property type="nucleotide sequence ID" value="XM_050612930.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VL67"/>
    <dbReference type="STRING" id="227321.C8VL67"/>
    <dbReference type="GeneID" id="74896299"/>
    <dbReference type="KEGG" id="ani:ANIA_10255"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN10255"/>
    <dbReference type="eggNOG" id="ENOG502SF32">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070640_0_0_1"/>
    <dbReference type="InParanoid" id="C8VL67"/>
    <dbReference type="OMA" id="TPEEWWV"/>
    <dbReference type="OrthoDB" id="1733656at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002993163" description="Peptidyl-tRNA hydrolase" evidence="2">
        <location>
            <begin position="17"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF85964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="255" mass="27891" checksum="F7DAF7FBFBD29AC4" modified="2009-11-03" version="1">MRFIPLLALLPALAVAEEQVPLADRVQGWFNKAKSYLPTATPVIPVAEKVAEVPKKVIQEKTVTPFNATNWQSLLEPAADAQDWLVFITGGNKTCFGRCGKAEEAFNQSVLLFAADPTSPNLGYLDCESNQLLCSAWSAGAPSVWYFKVPQAQVTGERPSTPLHIVYVNSTTVTPESIYRIHAEKTYENKPAYEGAFHPTDGWLAQCGLLVPLGYVIYGFGVVPSWLFMIVISMASRTMMSRRLGNPGAPAGRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>C8VM39</accession>
    <name>C8VM39_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ANIA_01425</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF84832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468634.1">
        <property type="nucleotide sequence ID" value="XM_050612753.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VM39"/>
    <dbReference type="STRING" id="227321.C8VM39"/>
    <dbReference type="GeneID" id="2875145"/>
    <dbReference type="KEGG" id="ani:ANIA_01425"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN1425"/>
    <dbReference type="eggNOG" id="ENOG502RHAD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006329_1_0_1"/>
    <dbReference type="InParanoid" id="C8VM39"/>
    <dbReference type="OMA" id="WDNVECI"/>
    <dbReference type="OrthoDB" id="4451586at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019626">
        <property type="term" value="P:short-chain fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.240.10:FF:000055">
        <property type="entry name" value="C6 transcription factor (Ctf1B)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052761">
        <property type="entry name" value="Fungal_Detox/Toxin_TFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47425">
        <property type="entry name" value="FARB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47425:SF2">
        <property type="entry name" value="FARB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="41"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="666"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="719"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="824"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="672"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="730"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="824"/>
            <end position="836"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBF84832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="853" mass="95104" checksum="23FDD14D11098EBF" modified="2009-11-03" version="1">MTDSPVAPNPAVETDPKSKRKASSAGLSANSRPVKRRASKACCCCRARKVRCDVVENGSPCTNCRLDQVECVVTESKRRKKSRVDTEISNPQLSQSPAEILDDGALFGGLGDTQGIPHVAPTSPSQGSVDMEQGQHMPHLLYQSQVNRVDPGDRFRKRMAPNPLVPSSMPLSHVTSEIQQLLDPSFGSPRSSGIVLPDYIRGLPARLQKEDIDYLAMKGALTVPDVTLRNELLKAYIHYVHTYMPLLDLEDFLQTIVQNDGIRRMSLLLFQAVMFAGTAFIDLKHLQAAGYPSRKSARKSFFQRARLLYDFDYEVDRISLVQSLLLMTYWYETPDDQKDTWHWMGVSLSLAHTIGLHRDPANSRMDVRRQRMWKRIWWSTYTRDRLIALGMRRPMRVKDDDCDVPMLTLDDFEFHPFSPEIVSMVGNSEILQSVAHQRELASMFIEKAKLCLCVSHVLSAQYSVLSHKFGGTMETTMMLVPKKSAAETFEVRRCDQELEDWLAHLPSEIQYAPAAPAKLSEAQEVLHSHRALLKMVYLTTSSALHRPQVLPAVPFPSMDTELQDMSRNKVRFAAIEITNIAQDLHSLDLTRYFPTTGVTVLLPAVIIHLLDIKSSDQNVRMTSLQRFYQCMRILQRLREIYASADFATSFLEAAIRKAGIQLTVPPQELQKRSNNSGASRNTTLTPPPDSLAQKIPDLTYPKTGSMGGMTLNLVDEAQPAFASTPPPSDGSENGSTNNINPNYHRDAFRIPNIDDTEMSLSQLMDLANDAEVTQNDFDALINFDDAGADFFSSENGVENMTGDGNSKNFPFTFQDMVGFDSGNKSDAAASNGADAAQTEAPNLDMDLGLSLNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>C8VN07</accession>
    <name>C8VN07_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MBL2-like secreted peptide, putative (AFU_orthologue AFUA_5G00910)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_01567</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF85125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468684.1">
        <property type="nucleotide sequence ID" value="XM_050612808.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VN07"/>
    <dbReference type="GeneID" id="2875642"/>
    <dbReference type="KEGG" id="ani:ANIA_01567"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN1567"/>
    <dbReference type="eggNOG" id="ENOG502ST40">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_125595_2_0_1"/>
    <dbReference type="InParanoid" id="C8VN07"/>
    <dbReference type="OMA" id="APWIAHE"/>
    <dbReference type="OrthoDB" id="2251794at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002991635" evidence="1">
        <location>
            <begin position="18"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF85125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="133" mass="14226" checksum="39DC9BB29F7C0431" modified="2009-11-03" version="1">MKFTVAGVLALASLALAMPAPEAAAVAEAEALEAPVPVDISPEALGLEKRANTVCKIVNSSSSKVNCRTGPGFDYPASYSVIPGKYYEFRCYKSGDCYNGNCTWQRINWDGKTCYVNGYYTDSKCTVAALGKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>C8VNC7</accession>
    <name>C8VNC7_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ANIA_10292</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
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            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
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        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="entry name" value="ER TRANSPORTER 6TM N-TERMINAL DOMAIN-CONTAINING PROTEIN-RELATED"/>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
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            <begin position="67"/>
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    <feature type="transmembrane region" description="Helical" evidence="5">
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            <begin position="34"/>
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            <begin position="639"/>
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    <sequence length="1017" mass="113913" checksum="E3041345C6615F28" modified="2009-11-03" version="1">MADQFPPRDYACENHGTDRRSVKCPSLVDKAKSVWNKTGLDLQSIMLMVKGAIPPTIGLAIYQADSIAAYFTTSGYLIAIISVLGFAIMPRAKFVQMMLLDILAVCVAAAVNALMMFATVKAREQSTSSDQSQPSSSGFPPYNSSASVTSGVFLFFQTYFVHSLRAHYQQFQFPVIIYSIVANVTFSFAPLLSTMPAALSMVRRLLEAALLGLGLSTGVSFFIFPLSCRAVVFKQMAGYISALRSALQAHTAYFEALESENVFGRTATYDSTVEKMDKHGKVYSPEATTIRKAVHKITELHGKMAGDLPFAKREIAIGELGPDDLQSIFRHLRQTMVPVVGLGFIVDIFERLSEYNKWNEPIDPSSVVSGDLRDRAVHEWHEIMTAVHDPFVSMIETIDEGLQHVAVTLKLTPAPKNVNLDPETASSRSPGNKGFSAYMERKLSDFKIAKQLALRTWSEEKGITLPPDFFEHPTTAHLETEDIPVDGSVDRDRARRQLFLFLYMEQLLASTGQVVLEFVRYADRKRESGKLSRTRLIIPGGKRLRKWALSIFKTGDPQGEDHLGDVNANNGVLQLGEAYTTRKDPEHLPPETTLQKLGDKIRRIAAMLRSPQSSYGFRVACATMTIAVVYFIRDTQEFFIRQRFVWAIIMVNLSMSPTSGQSLFGFALRIVGTILAMTLSLLCWYIPGKQTPGILVFFFLFVAATFYIPVKQFRFRIAGVITVISTAMIVGYELQARKIGEQNVSANGQTYYPIYLLAPYRLAVVTGGIAVAFFWTFFPYPISEHSVLRQNLGSSLYLLANYYSIIHETVTARMRGDEGDNALKTPAGRRLLKARNKVFSKQMIMLSSLRTYSEFLKWEVPIGGRFPKQQYDRIITCIEKPFMKLTAKPRFSIVNYLSLLGYASDSLKQLGNDDESDSAWLNDLRRLIASARITTHQITSVLCLLSASLTNQQPLPPFLKTPRPYSFSKRLEQLDKDILSLRHIAEPGFATFSVLQISTRCIVGDVELLMKYVIVRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>C8VPM6</accession>
    <name>C8VPM6_EMENI</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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        <name evidence="1" type="ORF">ANIA_01816</name>
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        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
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            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
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        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF85616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_050612875.1"/>
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        <property type="component" value="Chromosome VII"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF85616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="61" mass="6782" checksum="E9A20F97C1A90B78" modified="2009-11-03" version="1">MIVCEKCIGMAQTKPTYQYSWQVPGGGWERCEIDGCWAYMRKGDGVGSAGKGLWFMVLLGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>C8VPQ8</accession>
    <name>C8VPQ8_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Secretory component protein shr3, putative (AFU_orthologue AFUA_4G09660)</fullName>
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    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_01845</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF85675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468743.1">
        <property type="nucleotide sequence ID" value="XM_050612880.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VPQ8"/>
    <dbReference type="FunCoup" id="C8VPQ8">
        <property type="interactions" value="61"/>
    </dbReference>
    <dbReference type="STRING" id="227321.C8VPQ8"/>
    <dbReference type="GeneID" id="2875738"/>
    <dbReference type="KEGG" id="ani:ANIA_01845"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN1845"/>
    <dbReference type="eggNOG" id="ENOG502RXJB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080510_0_0_1"/>
    <dbReference type="InParanoid" id="C8VPQ8"/>
    <dbReference type="OMA" id="ANMLFDG"/>
    <dbReference type="OrthoDB" id="5229808at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013248">
        <property type="entry name" value="Psh3/Shr3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28228">
        <property type="entry name" value="SECRETORY COMPONENT PROTEIN SHR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28228:SF1">
        <property type="entry name" value="SECRETORY COMPONENT PROTEIN SHR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08229">
        <property type="entry name" value="SHR3_chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029187">
        <property type="entry name" value="Shr3_AAP_chap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00786">
        <property type="entry name" value="SHR3_chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF85675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="200" mass="21598" checksum="6301039BBD1EF777" modified="2009-11-03" version="1">MTLRYGSFATFLIVCPTSFFLGIIFSLFPYDYPILWSTSPTDSTAYDSLETHLRLLHASPPLIPRILHIVIFLGLAGLIMKLWKPSESNMLFDGASLVLYACGITVYVANIVKGLRLASGGVYGAELANAPDEVGQILGREDSLKVLSASNTILALVLVGVLVLQAGQWYAERKDAQEDESFAAVKGEGKGKGATKKKAN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2016-09-07" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>C8VQ62</accession>
    <accession>Q5BH28</accession>
    <name>MDPK_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Oxidoreductase mdpK</fullName>
            <ecNumber evidence="8">1.-.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Monodictyphenone synthesis protein k</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">mdpK</name>
        <name type="ORF">ANIA_10044</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2010" name="Appl. Environ. Microbiol." volume="76" first="2067" last="2074">
            <title>Characterization of the Aspergillus nidulans monodictyphenone gene cluster.</title>
            <authorList>
                <person name="Chiang Y.M."/>
                <person name="Szewczyk E."/>
                <person name="Davidson A.D."/>
                <person name="Entwistle R."/>
                <person name="Keller N.P."/>
                <person name="Wang C.C."/>
                <person name="Oakley B.R."/>
            </authorList>
            <dbReference type="PubMed" id="20139316"/>
            <dbReference type="DOI" id="10.1128/AEM.02187-09"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>PATHWAY</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2011" name="J. Am. Chem. Soc." volume="133" first="4010" last="4017">
            <title>Genome-based deletion analysis reveals the prenyl xanthone biosynthesis pathway in Aspergillus nidulans.</title>
            <authorList>
                <person name="Sanchez J.F."/>
                <person name="Entwistle R."/>
                <person name="Hung J.H."/>
                <person name="Yaegashi J."/>
                <person name="Jain S."/>
                <person name="Chiang Y.M."/>
                <person name="Wang C.C."/>
                <person name="Oakley B.R."/>
            </authorList>
            <dbReference type="PubMed" id="21351751"/>
            <dbReference type="DOI" id="10.1021/ja1096682"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>PATHWAY</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2012" name="ChemBioChem" volume="13" first="1680" last="1688">
            <title>Genetic and biosynthetic studies of the fungal prenylated xanthone shamixanthone and related metabolites in Aspergillus spp. revisited.</title>
            <authorList>
                <person name="Simpson T.J."/>
            </authorList>
            <dbReference type="PubMed" id="22730213"/>
            <dbReference type="DOI" id="10.1002/cbic.201200014"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>PATHWAY</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2013" name="PLoS ONE" volume="8" first="e62088" last="e62088">
            <title>Identification of metabolic pathways influenced by the G-protein coupled receptors GprB and GprD in Aspergillus nidulans.</title>
            <authorList>
                <person name="de Souza W.R."/>
                <person name="Morais E.R."/>
                <person name="Krohn N.G."/>
                <person name="Savoldi M."/>
                <person name="Goldman M.H."/>
                <person name="Rodrigues F."/>
                <person name="Caldana C."/>
                <person name="Semelka C.T."/>
                <person name="Tikunov A.P."/>
                <person name="Macdonald J.M."/>
                <person name="Goldman G.H."/>
            </authorList>
            <dbReference type="PubMed" id="23658706"/>
            <dbReference type="DOI" id="10.1371/journal.pone.0062088"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="1 2 3 8">Oxidoreductase; part of the gene cluster that mediates the biosynthesis of monodictyphenone, a prenyl xanthone derivative (PubMed:20139316, PubMed:21351751, PubMed:22730213). Within the pathway, mdpJ and mdpK are proposed to be involved in a branched path beginning at the mpdL lactone product and that leads to the formation of arugosin F (PubMed:22730213). The pathway begins with the synthesis of atrochrysone thioester by the polyketide synthase (PKS) mdpG. The atrochrysone carboxyl ACP thioesterase mdpF then breaks the thioester bond and releases the atrochrysone carboxylic acid from mdpG. The atrochrysone carboxylic acid is then converted to atrochrysone by mdpH-1 which is further transformed into emodin anthrone. The next step is performed by the anthrone oxygenase mdpH-2 that catalyzes the oxidation of emodinanthrone to emodin. Emodin is further modified to yield monodictyphenone via several steps involving mdpB, mdpC and mdpL. Mdpj and mdpK are part of a branching pathway leading to arugosin F, which is further converted to shamixanthone and epishamixanthone via several intermediates including arugosins I, H, A, B or variecoxanthone A. These reactions are performed by the FAD-dependent monooxygenase mdpD, the xanthone prenyltransferases xptA and xptB and the dehydrogenase xptC.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 2 3">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="induction">
        <text evidence="4">Expression is positively regulated by the gprD G-protein coupled receptor signaling pathway.</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="1 2 3">Impairs the production of monodictyphenone, but still enables the synthesis of intermediates until emodin (PubMed:20139316, PubMed:21351751). Results in major accumulation of chrysophanol and its 6-hydroxymethyl shunt product aloe-emodin (PubMed:22730213).</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the avfA family.</text>
    </comment>
    <comment type="sequence caution" evidence="7">
        <conflict type="erroneous gene model prediction">
            <sequence resource="EMBL-CDS" id="EAA66025" version="1"/>
        </conflict>
        <text>The predicted gene AN0152 has been split into 2 genes: ANIA_10044 and ANIA_10023.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="8"/>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF90090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AACD01000005">
        <property type="protein sequence ID" value="EAA66025.1"/>
        <property type="status" value="ALT_SEQ"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VQ62"/>
    <dbReference type="SMR" id="C8VQ62"/>
    <dbReference type="STRING" id="227321.C8VQ62"/>
    <dbReference type="EnsemblFungi" id="CBF90090">
        <property type="protein sequence ID" value="CBF90090"/>
        <property type="gene ID" value="ANIA_10044"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AN10044"/>
    <dbReference type="eggNOG" id="ENOG502SM0C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090039_1_0_1"/>
    <dbReference type="InParanoid" id="C8VQ62"/>
    <dbReference type="OMA" id="DNIPGCH"/>
    <dbReference type="OrthoDB" id="10254221at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900815">
        <property type="term" value="P:monodictyphenone biosynthetic process"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001307">
        <property type="term" value="P:xanthone-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15020">
        <property type="entry name" value="FLAVIN REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15020:SF37">
        <property type="entry name" value="OXIDOREDUCTASE MDPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-0503">Monooxygenase</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000437063" description="Oxidoreductase mdpK">
        <location>
            <begin position="1"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000269" key="1">
        <source>
            <dbReference type="PubMed" id="20139316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="21351751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="22730213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="23658706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="5">
        <source>
            <dbReference type="PubMed" id="20139316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="6">
        <source>
            <dbReference type="PubMed" id="21351751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="7"/>
    <evidence type="ECO:0000305" key="8">
        <source>
            <dbReference type="PubMed" id="22730213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBF90090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="265" mass="28877" checksum="8DFE9CA6D8B37725" modified="2009-11-03" version="1">MPLATYAVLGATGNTGTALIQNLLSPPSSEMHINAYCRNKPKLLNLLPELNDTKNVTIFEGSITDLSLITACIRNTRAVFLTVTSNDNIPGCRLSQDSVQTVLEALKQIRTAEPNAVVPKLVLLSSATIDPHLSRKMPSWFLPIMKTAASNVYADLIKAEEMLRANESWVTSIFIKPAGLSVDIQRGHKLDFDEQESFISYLDLAAAMLEAANDTDGRYDGRNVSVVNTGGKARFPPGTPKCIIVGLLRHFFPGLHRFLPTTGPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C8VQK5</accession>
    <name>C8VQK5_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNA helicase/RNAse III, putative (AFU_orthologue AFUA_5G11790)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_00119</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF90161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050469327.1">
        <property type="nucleotide sequence ID" value="XM_050611060.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VQK5"/>
    <dbReference type="STRING" id="227321.C8VQK5"/>
    <dbReference type="GeneID" id="2875893"/>
    <dbReference type="KEGG" id="ani:ANIA_00119"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN0119"/>
    <dbReference type="eggNOG" id="KOG0701">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_669073_0_0_1"/>
    <dbReference type="InParanoid" id="C8VQK5"/>
    <dbReference type="OMA" id="WTAILLE"/>
    <dbReference type="OrthoDB" id="416741at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051363">
        <property type="entry name" value="RLR_Helicase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14074:SF16">
        <property type="entry name" value="ANTIVIRAL INNATE IMMUNE RESPONSE RECEPTOR RIG-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14074">
        <property type="entry name" value="HELICASE WITH DEATH DOMAIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0347">Helicase</keyword>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="43"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF90161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="411" mass="47361" checksum="6204CA7C1BCD2B17" modified="2009-11-03" version="1">MNPEHYCGSGYRSWKDISSCALTQVHYRKELNNRTNGELHMISIFLVDSVTLSYKQAGVLRNNLDMNVGRIFGALGFDLWSRQTWTEFLEKYMVVVCTAEVLYQCLLHAHIRMEQINLLVFDEAHHTKKDHVCARIIRDSYFPTAQSKRPRVLGMTASPVDTKGDVAQAAMNLELYLDSKIATASQLSLVHQVVRRPKEEAWIYDRLEQSFGTEIYRLMEGRLGDIEDLKLVFRFAWQASFELGRWCSDGVLKYVFSAKMLPKLEGKSKELSQLRDASEVASSYILGSPEEPGQSSHKVQVLRRRLTEHYRETPETRSLVFTTRRYTTLMLLELFNALEMPHLRPGLLIGVQANDFAGPEISCREQFLAIDRFRSGEINCLIRPFCDFSGRRRSRYPLLVIWLYGSICPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>C8VR36</accession>
    <name>C8VR36_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">C2H2 type zinc finger domain protein (AFU_orthologue AFUA_1G02360)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ANIA_11212</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF87425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_677512.2"/>
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    <dbReference type="GeneID" id="2867860"/>
    <dbReference type="KEGG" id="ani:ANIA_11212"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN11212"/>
    <dbReference type="eggNOG" id="ENOG502QW9X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024140_0_0_1"/>
    <dbReference type="InParanoid" id="C8VR36"/>
    <dbReference type="OMA" id="SHMINTT"/>
    <dbReference type="OrthoDB" id="3945418at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
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    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
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        <property type="project" value="GO_Central"/>
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    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
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        <property type="project" value="GO_Central"/>
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    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000110">
        <property type="entry name" value="Zinc finger protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF14">
        <property type="entry name" value="C2H2 TYPE ZINC FINGER DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G02360)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="6"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="28"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBF87425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="687" mass="75526" checksum="70CBF70D45A8D232" modified="2009-11-03" version="1">MNGPPYRCTFCGRCFSRQDVLNRHLRVHSDPASSDAAEASGHTETRAQGTQQTLIGPTDWPLASDHDASSVQFPDSRYLPLCESPMGDTRPIPADLAPGLLWPDSEGLLENIMSVDPSVWQQPLALAPSTLGLEDAPEEFAGNRNHQSSCGNTIADDGRHAVQSLSSLLSDTVSTVTAPASLTGLTSRFLDGSLHMFFEKIIPMFPIFHRPTFVFRDCAPPLLLNAIALGALFLGSADAVAKAEVLWRLSHTAVATSWHTMITWRRTSDSCAGVELVQTVLLSQIYAAMSKNRTFRTTSQVFHGLGIHWASHCGMYDAANMVTLPMPTDSQSVKCKAWYRWIAQETMLRTLLGLYIVDGVVSQFSGNPTFARHTANPLALPSCDAVFNASSADDWIHLMQKYPATPIRFCDIYNDLFQETQASSSRPLLYDVSLFHHKVVLEGIRCLVTEMNGTNPPPVGVPSRQDLMSALRELRQHILNSKRLTPTDRLTALLQWHSICLDTVVSTARGTRRMCHLFGIGQSIFGGSQREEGQINPTRWAQSAAGRATLLHAINIQTIAAQLPLGMAYDINIPGAVFAAATTYSSFTLAGVSKIVYPAAIDWDTVLTTFPLDVRRPTGSESTMQCTLNFVTGYLDPTEMPRDKYVVRDLSYDLTAMRTLLRGLSLQWGVAVEMEGVVSAYIERCEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C8VT13</accession>
    <name>C8VT13_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS multidrug transporter, putative (AFU_orthologue AFUA_7G04900)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ANIA_10152</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF87985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050469030.1">
        <property type="nucleotide sequence ID" value="XM_050613197.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VT13"/>
    <dbReference type="GeneID" id="2876955"/>
    <dbReference type="KEGG" id="ani:ANIA_10152"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN10152"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_1_3_1"/>
    <dbReference type="InParanoid" id="C8VT13"/>
    <dbReference type="OMA" id="MGCLQGM"/>
    <dbReference type="OrthoDB" id="6770063at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF143">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G04900)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="62"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="215"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="283"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="330"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="371"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="396"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="423"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="457"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="62"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBF87985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="479" mass="52977" checksum="5FB24644ADDF669D" modified="2009-11-03" version="1">MRLRDSRTPDQGSPPRTLKTAERRPSTLKPTPKPKIRISLLGGGQMTQKNPRKWPNSMKPRNSWAVSLFVFISPVSSSMIAPAMQNLGSDLGMQTEIEIYLSMAIFILAYAIGPTFFGPASELYGRVRLLQISNIWYLAWNLGCGFANTKAQLFAFRFLAGIGGSAPLAIGGGAVGDMWSAEERGKAMGVYTLGPLLGPVVGPIAGGFIAEYTTWRWVFWASSAAAVGIQLAGFVWLRECHPATLLRMRRDCLVKETGNENFHVEERAEALTHKLLHAFERPVLLSITQPIVTCIAVYMAYIFGVTYLMLATFPDIWTEVYDETRSISSVNYVSIALGSFTGLFLNLKFIDRIYRVLKARNNNIGKPEFRMPALAIGSIISTIGLFWYGWSIGTRYWIMPDIGAAIFAAGTISCLYQTYAASAMAACAILRSLAGFAFPLFAPYMYQSLGYQWGTSVLAFVTIGIVWTAPFGFWYFGRC</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2016-04-13" modified="2025-06-18" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>G5EB89</accession>
    <accession>C8VM76</accession>
    <accession>Q5BBD8</accession>
    <accession>Q8X175</accession>
    <name>KAPA_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Importin subunit alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Karyopherin alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">kapA</name>
        <name type="synonym">srp1</name>
        <name type="ORF">AN2142</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="Fungal Genet. Biol." volume="45" first="278" last="291">
            <title>NapA and NapB are the Aspergillus nidulans Nap/SET family members and NapB is a nuclear protein specifically interacting with importin alpha.</title>
            <authorList>
                <person name="Araujo-Bazan L."/>
                <person name="Fernandez-Martinez J."/>
                <person name="Rios V.M."/>
                <person name="Etxebeste O."/>
                <person name="Albar J.P."/>
                <person name="Penalva M.A."/>
                <person name="Espeso E.A."/>
            </authorList>
            <dbReference type="PubMed" id="17890114"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2007.08.003"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <scope>INTERACTION WITH HSP70; HSP90; NAPB; NKUA; NUDK; AN1413 AND NIME</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2003" name="Eukaryot. Cell" volume="2" first="209" last="221">
            <title>Nuclear import of zinc binuclear cluster proteins proceeds through multiple, overlapping transport pathways.</title>
            <authorList>
                <person name="Nikolaev I."/>
                <person name="Cochet M.-F."/>
                <person name="Felenbok B."/>
            </authorList>
            <dbReference type="PubMed" id="12684370"/>
            <dbReference type="DOI" id="10.1128/EC.2.2.209-221.2003"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2007" name="Mol. Microbiol." volume="63" first="242" last="255">
            <title>Aspergillus nidulans VeA subcellular localization is dependent on the importin alpha carrier and on light.</title>
            <authorList>
                <person name="Stinnett S.M."/>
                <person name="Espeso E.A."/>
                <person name="Cobeno L."/>
                <person name="Araujo-Bazan L."/>
                <person name="Calvo A.M."/>
            </authorList>
            <dbReference type="PubMed" id="17163983"/>
            <dbReference type="DOI" id="10.1111/j.1365-2958.2006.05506.x"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="506" last="515">
            <title>Importin alpha is an essential nuclear import carrier adaptor required for proper sexual and asexual development and secondary metabolism in Aspergillus nidulans.</title>
            <authorList>
                <person name="Araujo-Bazan L."/>
                <person name="Dhingra S."/>
                <person name="Chu J."/>
                <person name="Fernandez-Martinez J."/>
                <person name="Calvo A.M."/>
                <person name="Espeso E.A."/>
            </authorList>
            <dbReference type="PubMed" id="19318129"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2009.03.006"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>MUTAGENESIS OF SER-111</scope>
    </reference>
    <comment type="function">
        <text evidence="6 7 9">Import of proteins with classical NLS composed of one or two clusters of basic residues is initiated by binding to the importin alpha/beta heterodimer, where importin alpha acts as an adapter subunit to bridge NLS cargos to importin beta, which transports the whole complex through the nuclear envelope (PubMed:12684370). Involved in the nuclear accumulation of the light-dependent developmental regulator veA (PubMed:17163983, PubMed:19318129). Participates at different regulatory stages of asexual and sexual development, being required for the completion of both reproductive cycles with the formation of conidiospores and ascospores, respectively (PubMed:19318129). Mediates secondary metabolite gene expression with positive regulation of penicillin production and negative regulation of mycotoxin biosynthesis (PubMed:19318129).</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 8">Forms a complex with an importin beta subunit (By similarity). Interacts with hsp70, hsp90, napB, nkuA, nudK, AN1413 and nimE (PubMed:17890114).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="9">Leads to lethality (PubMed:19318129).</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the importin alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="AF465210">
        <property type="protein sequence ID" value="AAL69976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF86262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AACD01000034">
        <property type="protein sequence ID" value="EAA64186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_659746.1">
        <property type="nucleotide sequence ID" value="XM_654654.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G5EB89"/>
    <dbReference type="SMR" id="G5EB89"/>
    <dbReference type="FunCoup" id="G5EB89">
        <property type="interactions" value="1058"/>
    </dbReference>
    <dbReference type="STRING" id="227321.G5EB89"/>
    <dbReference type="EnsemblFungi" id="CBF86262">
        <property type="protein sequence ID" value="CBF86262"/>
        <property type="gene ID" value="ANIA_02142"/>
    </dbReference>
    <dbReference type="GeneID" id="2875733"/>
    <dbReference type="KEGG" id="ani:ANIA_02142"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN2142"/>
    <dbReference type="eggNOG" id="KOG0166">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018084_6_0_1"/>
    <dbReference type="InParanoid" id="G5EB89"/>
    <dbReference type="OMA" id="EMIQMLY"/>
    <dbReference type="OrthoDB" id="29145at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061608">
        <property type="term" value="F:nuclear import signal receptor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008139">
        <property type="term" value="F:nuclear localization sequence binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006607">
        <property type="term" value="P:NLS-bearing protein import into nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.690:FF:000003">
        <property type="entry name" value="Importin subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000021">
        <property type="entry name" value="Importin subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.690">
        <property type="entry name" value="Importin-alpha, importin-beta-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032413">
        <property type="entry name" value="Arm_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002652">
        <property type="entry name" value="Importin-a_IBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036975">
        <property type="entry name" value="Importin-a_IBB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024931">
        <property type="entry name" value="Importin_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23316">
        <property type="entry name" value="IMPORTIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00514">
        <property type="entry name" value="Arm"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16186">
        <property type="entry name" value="Arm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01749">
        <property type="entry name" value="IBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005673">
        <property type="entry name" value="Importin_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51214">
        <property type="entry name" value="IBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-0653">Protein transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000435924" description="Importin subunit alpha">
        <location>
            <begin position="1"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="domain" description="IBB" evidence="4">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM 1" evidence="3">
        <location>
            <begin position="115"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM 2" evidence="3">
        <location>
            <begin position="157"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM 3" evidence="3">
        <location>
            <begin position="199"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM 4" evidence="3">
        <location>
            <begin position="242"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM 5" evidence="3">
        <location>
            <begin position="284"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM 6" evidence="3">
        <location>
            <begin position="326"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM 7" evidence="3">
        <location>
            <begin position="368"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM 8" evidence="3">
        <location>
            <begin position="413"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="530"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="mutagenesis site" description="Leads to thermosensitivity and affects nuclear import at the restrictive temperature." evidence="9">
        <original>S</original>
        <variation>F</variation>
        <location>
            <position position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="B6HJ92"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="Q02821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3"/>
    <evidence type="ECO:0000255" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="6">
        <source>
            <dbReference type="PubMed" id="12684370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="7">
        <source>
            <dbReference type="PubMed" id="17163983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="8">
        <source>
            <dbReference type="PubMed" id="17890114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="9">
        <source>
            <dbReference type="PubMed" id="19318129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="10">
        <source>
            <dbReference type="PubMed" id="19318129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="11"/>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAA64186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000005890"/>
        </source>
    </evidence>
    <sequence length="553" mass="60627" checksum="FEA035D324290A2A" modified="2011-12-14" version="1">MAERYIPEHRRTQYKARNQFRPDELRRRREEQQVEIRKQKREENLAKRRGIQTRDGGIGVGGGMAAAESDDEASAIESELNVELPEMVKGVFSDQIEAQIQATTKFRKLLSKERNPPIERVIETGVVSRFVEFLRSPHTLVQFEAAWALTNIASGSAQQTQVVIEAGAVPIFVELLSSPEPDVREQAVWALGNIAGDSPQCRDFVLNAGALRPLLTLINDGRKISMLRNATWTLSNFCRGKTPQPDWNTIAPALPVLAKLIYMLDDEVLIDACWAISYLSDGPNEKIQAVIEAGIPRRLVELLMHASTSVQTPALRSVGNIVTGDDVQTQVIINCGALPALLSLLSSTKDGIRKEACWTISNITAGNSSQIQSVIDAGIIPPLVHLLANGDFKTRKEACWAISNATSGGLQKPDQIRYLVTQGCIKPLCDLLACPDNKIIQVALDGLENILKVGEMDKEAGQGDAHVNRYALFIEEAGGMEKIHDCQNNANEEIYMKAYNIIEKYFSDEDEAAGDIDELAPQQTQTGFTLGATQQQPGGFSFGGANGGDSMDM</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-04-05" modified="2025-04-09" version="127" xmlns="https://uniprot.org/uniprot">
    <accession>O93885</accession>
    <accession>C8V2W4</accession>
    <accession>Q5AXU2</accession>
    <name>PEPA_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Aspergillopepsin-1</fullName>
            <ecNumber evidence="1">3.4.23.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Aspartic protease pepA</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Aspergillopepsin I</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Aspergillopeptidase A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Proctase B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">prtB</name>
        <name type="synonym">pepA</name>
        <name type="ORF">AN6888</name>
    </gene>
    <organism>
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Fungal Genet. Biol." volume="29" first="201" last="210">
            <title>Analysis of two Aspergillus nidulans genes encoding extracellular proteases.</title>
            <authorList>
                <person name="vanKuyk P.A."/>
                <person name="Cheetham B.F."/>
                <person name="Katz M.E."/>
            </authorList>
            <dbReference type="PubMed" id="10882536"/>
            <dbReference type="DOI" id="10.1006/fgbi.2000.1195"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <scope>INDUCTION</scope>
        <source>
            <strain>MH2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Secreted aspartic endopeptidase that allows assimilation of proteinaceous substrates. The scissile peptide bond is attacked by a nucleophilic water molecule activated by two aspartic residues in the active site. Shows a broad primary substrate specificity. Favors hydrophobic residues at the P1 and P1' positions, but also accepts a lysine residue in the P1 position, leading to the activation of trypsinogen and chymotrypsinogen A.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of proteins with broad specificity. Generally favors hydrophobic residues in P1 and P1', but also accepts Lys in P1, which leads to activation of trypsinogen. Does not clot milk.</text>
            <dbReference type="EC" id="3.4.23.18"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="5">Expressed, albeit at a very low level.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.23.18" evidence="1"/>
    <dbReference type="EMBL" id="AF090736">
        <property type="protein sequence ID" value="AAD04378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AACD01000113">
        <property type="protein sequence ID" value="EAA58287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF71666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_664492.1">
        <property type="nucleotide sequence ID" value="XM_659400.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O93885"/>
    <dbReference type="SMR" id="O93885"/>
    <dbReference type="STRING" id="227321.O93885"/>
    <dbReference type="MEROPS" id="A01.026"/>
    <dbReference type="GlyCosmos" id="O93885">
        <property type="glycosylation" value="1 site, No reported glycans"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CBF71666">
        <property type="protein sequence ID" value="CBF71666"/>
        <property type="gene ID" value="ANIA_06888"/>
    </dbReference>
    <dbReference type="KEGG" id="ani:ANIA_06888"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN6888"/>
    <dbReference type="eggNOG" id="KOG1339">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013253_0_1_1"/>
    <dbReference type="InParanoid" id="O93885"/>
    <dbReference type="OMA" id="DEEYIGN"/>
    <dbReference type="OrthoDB" id="2747330at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd06097">
        <property type="entry name" value="Aspergillopepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000024">
        <property type="entry name" value="Endothiapepsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000026">
        <property type="entry name" value="Endothiapepsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034163">
        <property type="entry name" value="Aspergillopepsin-like_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF2">
        <property type="entry name" value="ASPERGILLOPEPSIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-0064">Aspartyl protease</keyword>
    <keyword id="KW-1015">Disulfide bond</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0645">Protease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <keyword id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="propeptide" id="PRO_0000407048" description="Activation peptide" evidence="1">
        <location>
            <begin position="21"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000407049" description="Aspergillopepsin-1">
        <location>
            <begin position="70"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="4">
        <location>
            <begin position="85"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="275"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="311"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="Q12567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="10882536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="6">
        <source>
            <dbReference type="PubMed" id="10882536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="7"/>
    <sequence length="386" mass="41194" checksum="F50654A022D1E6A1" modified="1999-05-01" version="1" precursor="true">MVVFSKVAAAAFGLSAVASAMPAAPPRQGFTINQLTRAIPKRTINLPAIYANALSKYGGNVPPHIQDAMAHGSAVTTPEQYDVEYLTPVAVGGTTMNLDFDTGSADLWVFSNELPSSQTTGHSVYKPSDNGTRMSGYSWEISYGDGSSAGGDVYRDTVTVGGVTAPGQAVEAASHISEQFTRDQNNDGLLGLAFSSINTVQPKSQTTFFDSVKSQLESPLFAVTLKHQAPGSYDFGYIDQSKYTGELTYTDVDNSQGFWMFSATAGETDFDAIADTGTTLIMIDQSIAEDYYSQVPLAFNNFFYGGWTFPCSAELPSFTVTINGYDAVVPGEHIKYAPVTDGSSTCFGGIQDNQGLPFSILGDVFLKSQYVVFDSEGPQLGFAPQA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1997-11-01" modified="2026-01-28" version="142" xmlns="https://uniprot.org/uniprot">
    <accession>Q12611</accession>
    <accession>C8VJ82</accession>
    <accession>Q5B979</accession>
    <name>ARGI_EMENI</name>
    <protein>
        <recommendedName>
            <fullName>Arginase</fullName>
            <ecNumber evidence="2">3.5.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">agaA</name>
        <name type="ORF">AN2901</name>
    </gene>
    <organism>
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1999" name="Acta Biochim. Pol." volume="46" first="391" last="403">
            <title>Structure of the arginase coding gene and its transcript in Aspergillus nidulans.</title>
            <authorList>
                <person name="Borsuk P."/>
                <person name="Dzikowska A."/>
                <person name="Empel J."/>
                <person name="Grzelak A."/>
                <person name="Grzeskowiak R."/>
                <person name="Weglenski P."/>
            </authorList>
            <dbReference type="PubMed" id="10547040"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-arginine + H2O = urea + L-ornithine</text>
            <dbReference type="Rhea" id="RHEA:20569"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="EC" id="3.5.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="4">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nitrogen metabolism; urea cycle; L-ornithine and urea from L-arginine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the arginase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.3.1" evidence="2"/>
    <dbReference type="EMBL" id="U62482">
        <property type="protein sequence ID" value="AAB05775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AACD01000051">
        <property type="protein sequence ID" value="EAA63472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF83783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_660505.1">
        <property type="nucleotide sequence ID" value="XM_655413.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q12611"/>
    <dbReference type="SMR" id="Q12611"/>
    <dbReference type="FunCoup" id="Q12611">
        <property type="interactions" value="1323"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q12611"/>
    <dbReference type="EnsemblFungi" id="CBF83783">
        <property type="protein sequence ID" value="CBF83783"/>
        <property type="gene ID" value="ANIA_02901"/>
    </dbReference>
    <dbReference type="KEGG" id="ani:ANIA_02901"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN2901"/>
    <dbReference type="eggNOG" id="KOG2965">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039478_6_1_1"/>
    <dbReference type="InParanoid" id="Q12611"/>
    <dbReference type="OMA" id="YKEFRYA"/>
    <dbReference type="OrthoDB" id="9992747at2759"/>
    <dbReference type="UniPathway" id="UPA00158">
        <property type="reaction ID" value="UER00270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004053">
        <property type="term" value="F:arginase activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006525">
        <property type="term" value="P:arginine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000050">
        <property type="term" value="P:urea cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd09989">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.10:FF:000009">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.10">
        <property type="entry name" value="Ureohydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014033">
        <property type="entry name" value="Arginase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006035">
        <property type="entry name" value="Ureohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020855">
        <property type="entry name" value="Ureohydrolase_Mn_BS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01229">
        <property type="entry name" value="rocF_arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43782">
        <property type="entry name" value="ARGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43782:SF3">
        <property type="entry name" value="ARGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00491">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00116">
        <property type="entry name" value="ARGINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01053">
        <property type="entry name" value="ARGINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51409">
        <property type="entry name" value="ARGINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0056">Arginine metabolism</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0464">Manganese</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000173708" description="Arginase">
        <location>
            <begin position="1"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="145"/>
            <end position="149"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="156"/>
            <end position="158"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; AAB05775." evidence="5" ref="1">
        <original>E</original>
        <variation>V</variation>
        <location>
            <position position="35"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; AAB05775." evidence="5" ref="1">
        <original>I</original>
        <variation>V</variation>
        <location>
            <position position="71"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; AAB05775." evidence="5" ref="1">
        <original>A</original>
        <variation>G</variation>
        <location>
            <position position="86"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; AAB05775." evidence="5" ref="1">
        <original>S</original>
        <variation>R</variation>
        <location>
            <position position="95"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; AAB05775." evidence="5" ref="1">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; AAB05775." evidence="5" ref="1">
        <original>A</original>
        <variation>V</variation>
        <location>
            <position position="258"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; AAB05775." evidence="5" ref="1">
        <original>R</original>
        <variation>C</variation>
        <location>
            <position position="272"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; AAB05775." evidence="5" ref="1">
        <original>E</original>
        <variation>V</variation>
        <location>
            <position position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="P05089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="3">
        <source>
            <dbReference type="UniProtKB" id="P53608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <sequence length="324" mass="35479" checksum="5767BEB9D7987A16" modified="2007-05-01" version="2">MTSPSTIKQRFLSKPNQLGVVAVGFNGGQCKLGVEAAPMALVEAGLLDQLRDDLDYEIHYDNTVHYYEKEIPAEDPDHRGMKKPRAVSAVTETLSSQVYEHSKEGKFTLTLGGDHSIAIGSISGIAKATRERLGREIGVIWVDAHADINIPEMSPSGNIHGMPMAFLTRLATEEKKDIFGWLQEEHKVNLRKLVYIGLRDVDRGEKKLLREHGIKAFSMHDVDRHGIGRVVEMALAHIGNDTPIHLSFDVDALDPQWAPSTGTPVRGGLTLREGDFICECVHETGNLISMDLVEVNPSLEAVGASDTIRTGCSLVRSALGDTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AR16</accession>
    <accession>C8VQA8</accession>
    <name>Q5AR16_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="8">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ANIA_09264</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the tannase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="8"/>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF87284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_682533.1">
        <property type="nucleotide sequence ID" value="XM_677441.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AR16"/>
    <dbReference type="STRING" id="227321.Q5AR16"/>
    <dbReference type="GeneID" id="2867851"/>
    <dbReference type="KEGG" id="ani:ANIA_09264"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN9264"/>
    <dbReference type="eggNOG" id="ENOG502SH94">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1354601_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AR16"/>
    <dbReference type="OrthoDB" id="3039123at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030600">
        <property type="term" value="F:feruloyl esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011118">
        <property type="entry name" value="Tannase/feruloyl_esterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938:SF8">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938">
        <property type="entry name" value="FERULOYL ESTERASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07519">
        <property type="entry name" value="Tannase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBF87284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="202" mass="21475" checksum="580A6324BD0AB44B" modified="2005-04-26" version="1">MVSFCIQNVFIFLDTALFADTWTSSLYSLSALLIGAATALECSPASIRSPTFRNGRFQSLDSGDYSTGLEPIYLAYAVAQGFVSAFTDGGVPSDAGATTTIATDLSATNDMAEIGKQVTAYYNRPAEYTYFSGCSGGGREGHAMAQQFSDAFDGILALSPAITIESLIPASYWPTQITNENQIYPSPCEIDAFVSAAVKHCD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2016-06-08" modified="2026-01-28" version="138" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AR32</accession>
    <accession>C8VQ85</accession>
    <name>AUSG_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cytochrome P450 monooxygenase ausG</fullName>
            <ecNumber evidence="8">1.-.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Austinoid biosynthesis clusters protein G</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ausG</name>
        <name type="ORF">AN9248</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2012" name="ACS Chem. Biol." volume="7" first="599" last="606">
            <title>Signaling the induction of sporulation involves the interaction of two secondary metabolites in Aspergillus nidulans.</title>
            <authorList>
                <person name="Rodriguez-Urra A.B."/>
                <person name="Jimenez C."/>
                <person name="Nieto M.I."/>
                <person name="Rodriguez J."/>
                <person name="Hayashi H."/>
                <person name="Ugalde U."/>
            </authorList>
            <dbReference type="PubMed" id="22234162"/>
            <dbReference type="DOI" id="10.1021/cb200455u"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2012" name="J. Am. Chem. Soc." volume="134" first="4709" last="4720">
            <title>Two separate gene clusters encode the biosynthetic pathway for the meroterpenoids austinol and dehydroaustinol in Aspergillus nidulans.</title>
            <authorList>
                <person name="Lo H.C."/>
                <person name="Entwistle R."/>
                <person name="Guo C.J."/>
                <person name="Ahuja M."/>
                <person name="Szewczyk E."/>
                <person name="Hung J.H."/>
                <person name="Chiang Y.M."/>
                <person name="Oakley B.R."/>
                <person name="Wang C.C."/>
            </authorList>
            <dbReference type="PubMed" id="22329759"/>
            <dbReference type="DOI" id="10.1021/ja209809t"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2013" name="J. Am. Chem. Soc." volume="135" first="10962" last="10965">
            <title>Spiro-ring formation is catalyzed by a multifunctional dioxygenase in austinol biosynthesis.</title>
            <authorList>
                <person name="Matsuda Y."/>
                <person name="Awakawa T."/>
                <person name="Wakimoto T."/>
                <person name="Abe I."/>
            </authorList>
            <dbReference type="PubMed" id="23865690"/>
            <dbReference type="DOI" id="10.1021/ja405518u"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2017" name="ACS Chem. Biol." volume="12" first="2927" last="2933">
            <title>Rewiring of the austinoid biosynthetic pathway in filamentous fungi.</title>
            <authorList>
                <person name="Mattern D.J."/>
                <person name="Valiante V."/>
                <person name="Horn F."/>
                <person name="Petzke L."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="29076725"/>
            <dbReference type="DOI" id="10.1021/acschembio.7b00814"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="3 4 5 6">Cytochrome P450 monooxygenase; part of the gene cluster B that mediates the biosynthesis of austinol and dehydroaustinol, two fungal meroterpenoids (PubMed:22329759). The first step of the pathway is the synthesis of 3,5-dimethylorsellinic acid by the polyketide synthase ausA (PubMed:22329759). 3,5-dimethylorsellinic acid is then prenylated by the polyprenyl transferase ausN (PubMed:22329759). Further epoxidation by the FAD-dependent monooxygenase ausM and cyclization by the probable terpene cyclase ausL lead to the formation of protoaustinoid A (PubMed:22329759). Protoaustinoid A is then oxidized to spiro-lactone preaustinoid A3 by the combined action of the FAD-binding monooxygenases ausB and ausC, and the dioxygenase ausE (PubMed:22329759, PubMed:23865690). Acid-catalyzed keto-rearrangement and ring contraction of the tetraketide portion of preaustinoid A3 by ausJ lead to the formation of preaustinoid A4 (PubMed:22329759). The aldo-keto reductase ausK, with the help of ausH, is involved in the next step by transforming preaustinoid A4 into isoaustinone which is in turn hydroxylated by the P450 monooxygenase ausI to form austinolide (PubMed:22329759). Finally, the cytochrome P450 monooxygenase ausG modifies austinolide to austinol (PubMed:22329759). Austinol can be further modified to dehydroaustinol which forms a diffusible complex with diorcinol that initiates conidiation (PubMed:22234162, PubMed:22329759). Due to genetic rearrangements of the clusters and the subsequent loss of some enzymes, the end products of the Emericella nidulans austinoid biosynthesis clusters are austinol and dehydroaustinol, even if additional enzymes, such as the O-acetyltransferase ausQ and the cytochrome P450 monooxygenase ausR are still functional (PubMed:29076725).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Secondary metabolite biosynthesis; terpenoid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="4">Impairs the synthesis of austinol and dehydroaustinol and accumulates the intermediate compound austinolide (PubMed:22329759).</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="9">In A.calidoustus, the austinoid gene cluster lies on a contiguous DNA region, while clusters from E.nidulans and P.brasilianum are split in their respective genomes. Genetic rearrangements provoked variability among the clusters and E.nidulans produces the least number of austionoid derivatives with the end products austinol and dehydroaustinol, while P.brasilianum can produce until acetoxydehydroaustin, and A.calidoustus produces the highest number of identified derivatives.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="8"/>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF87243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AACD01000172">
        <property type="protein sequence ID" value="EAA66315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_682517.1">
        <property type="nucleotide sequence ID" value="XM_677425.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AR32"/>
    <dbReference type="SMR" id="Q5AR32"/>
    <dbReference type="STRING" id="227321.Q5AR32"/>
    <dbReference type="EnsemblFungi" id="CBF87243">
        <property type="protein sequence ID" value="CBF87243"/>
        <property type="gene ID" value="ANIA_09248"/>
    </dbReference>
    <dbReference type="KEGG" id="ani:ANIA_09248"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN9248"/>
    <dbReference type="eggNOG" id="KOG0157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022195_0_3_1"/>
    <dbReference type="InParanoid" id="Q5AR32"/>
    <dbReference type="OMA" id="IEWFERT"/>
    <dbReference type="OrthoDB" id="1844152at2759"/>
    <dbReference type="UniPathway" id="UPA00213"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900560">
        <property type="term" value="P:austinol biosynthetic process"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900563">
        <property type="term" value="P:dehydroaustinol biosynthetic process"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd11041">
        <property type="entry name" value="CYP503A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000059">
        <property type="entry name" value="Cytochrome P450 monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206:SF2">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE AUSG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0349">Heme</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0503">Monooxygenase</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000436488" description="Cytochrome P450 monooxygenase ausG">
        <location>
            <begin position="1"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="1">
        <location>
            <position position="470"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P04798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="22234162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="22329759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="23865690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="6">
        <source>
            <dbReference type="PubMed" id="29076725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="7">
        <source>
            <dbReference type="PubMed" id="22329759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="8"/>
    <evidence type="ECO:0000305" key="9">
        <source>
            <dbReference type="PubMed" id="29076725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAA66315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005890"/>
        </source>
    </evidence>
    <sequence length="529" mass="59273" checksum="AE112910E46E5D17" modified="2005-04-26" version="1">MAMGNPELRTHFFRSSHEPGIPNSLRFPNGFLVTCGLPWLLLLFSVTIILFHPLRKKSDLPLINPGKGRIGILRGYRSRKTFTTELPRLVADGLSKASAFRIAAPDGVNIVLAPSYAHEIAEHPDLNPGPIAGDEFNSHINGFEVFAQLGTSDVISESVRTRLTRQLTKLTPLLTSETPLLLQSQWKDAPDWVEVSPHETALFILSRLSSLVFVGDDLGRNPDWIRILTSYNTEAFAAAEELNLWPQILRPLIARLKPSCRQLRRYIRDARALLVPVLEQRRHAQSQGDRREYNDAIEWLDETSRSTGQPYDPILSQMLLAIGSFHTSSDLLGQVLLDLCMRPDWKVLVRELRKEIISSLQGEGWDKIALNNLKLMDSVLKESQRLKPASTVTMGRYASREITLSDGTIIPKGSTVFIANVAMRDSNIYPDPDDFVPDRFTTRREKGDSSAYLVSASPEHLGFGLGRHACPGRFFAANELKIVLSHMLMKYDIKLPDNGAVAPSKSGIFLATNPDARICVRRRKEEIVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AR99</accession>
    <accession>C8VJV5</accession>
    <name>Q5AR99_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Oxidoreductase CipA-like, putative (AFU_orthologue AFUA_1G12460)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ANIA_09181</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF82374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_682450.1">
        <property type="nucleotide sequence ID" value="XM_677358.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AR99"/>
    <dbReference type="GeneID" id="2868014"/>
    <dbReference type="KEGG" id="ani:ANIA_09181"/>
    <dbReference type="eggNOG" id="ENOG502S12R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044876_3_2_1"/>
    <dbReference type="InParanoid" id="Q5AR99"/>
    <dbReference type="OMA" id="MATKNIQ"/>
    <dbReference type="OrthoDB" id="9974981at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05259">
        <property type="entry name" value="PCBER_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045312">
        <property type="entry name" value="PCBER-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF1">
        <property type="entry name" value="CIPA-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12460)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="4">
        <location>
            <begin position="104"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="47"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="63"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBF82374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="344" mass="37205" checksum="8439A21F0B78D176" modified="2005-04-26" version="1">MATKNIQNVAVAGVNGNLGPAVLHALITSGLFKITIFTRLKAENDAGIRSPSSTSAPIQVPVNSNGNCSDSGNSTGTPKPSIQTLPVNYDSVDDLTTHLTAHSIHAVVSLLPHTAPDKQMNLIQAAVAAGVYRFIPSEFGSDLDNPVNRAAPTYKGKVNIQELLKRLAAENKISYTIIYNGAFLDWGLTHAFPIDVGKRTAVLYDGGERVYSTTTQPTIGHAVVSVLANPEETKNRVVRIAEANVTIKQLLSLVQEVVGDKDWTVNETDIDQEVEKAWALIKQGVFSFESMMPFIYRAGWGKDAGGHFETTDNILLGVDELDTEGVKRVIEGVVKKLRDEAFSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ARM8</accession>
    <accession>C8VKP6</accession>
    <name>Q5ARM8_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_09052</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF84386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_682321.1">
        <property type="nucleotide sequence ID" value="XM_677229.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ARM8"/>
    <dbReference type="STRING" id="227321.Q5ARM8"/>
    <dbReference type="GeneID" id="2868173"/>
    <dbReference type="KEGG" id="ani:ANIA_09052"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN9052"/>
    <dbReference type="eggNOG" id="ENOG502SVW0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089018_0_0_1"/>
    <dbReference type="InParanoid" id="Q5ARM8"/>
    <dbReference type="OMA" id="NCHPQGG"/>
    <dbReference type="OrthoDB" id="3552888at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35605">
        <property type="entry name" value="ECP2 EFFECTOR PROTEIN DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35605:SF1">
        <property type="entry name" value="ECP2 EFFECTOR PROTEIN DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010306784" evidence="1">
        <location>
            <begin position="20"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF84386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="198" mass="22104" checksum="347C3245AA6E4505" modified="2005-04-26" version="1">MRTIYITALIAFLALEAFGYPTDTDAVTEPAFPGYEDGTTTFQVVPYPDADKITLSGTMQEVHAKILEINPIYEEDWKNVNNTYSKPEPRSDKPPLLNCDGRNGYAKIDKINDGISYLRKFKLPPGLEGNTCQMVSCSYDSAISWCNALPTLRVLPSFDNIADGAQVILNWCQVDWDNVGGVLGHPDSWRVFVDKEKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="103" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ARP9</accession>
    <accession>C8VKR8</accession>
    <name>Q5ARP9_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fumarylacetoacetate hydrolase family protein (AFU_orthologue AFUA_4G01490)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ANIA_09031</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAH family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF84427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_682300.1">
        <property type="nucleotide sequence ID" value="XM_677208.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ARP9"/>
    <dbReference type="STRING" id="227321.Q5ARP9"/>
    <dbReference type="GeneID" id="2868242"/>
    <dbReference type="KEGG" id="ani:ANIA_09031"/>
    <dbReference type="eggNOG" id="KOG1535">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028458_2_1_1"/>
    <dbReference type="InParanoid" id="Q5ARP9"/>
    <dbReference type="OMA" id="WTRLVRY"/>
    <dbReference type="OrthoDB" id="411064at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050163">
        <property type="term" value="F:oxaloacetate tautomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006107">
        <property type="term" value="P:oxaloacetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.850.10:FF:000002">
        <property type="entry name" value="2-hydroxyhepta-2,4-diene-1,7-dioate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="entry name" value="Fumarylacetoacetase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820">
        <property type="entry name" value="ACYLPYRUVASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820:SF100">
        <property type="entry name" value="FUMARYLACETOACETATE HYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_4G01490)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="FAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarylacetoacetase-like C-terminal" evidence="3">
        <location>
            <begin position="81"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBF84427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="295" mass="32332" checksum="A6552017EF4B7275" modified="2005-04-26" version="1">MCPIEICWTHLVRYSSTANGPIKYGEPILGQTGDIGKLARDDQLKVKRLLGSDPFLLEKTDVVETVYRLYGPLEPKDVPIIRCIGLNYKTHILETGRPLPTCPTVFTKPSPAVADHDAPVPIPKIAQEQCDYEGELVIVIGREGKNIPEAEALNYVAAYTAGNDISARDWQREAGKAGPVPQWTFSKSFDNYAPLGPCLVRQDQLNEASMLSLRTLVNGDVRQESHTSDLCFGVRKLVAFCSQGQTLQRGSLIMTGTPGGVGLFMKPPQFLKDGDVVSVEIESIGTLQNTISFEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ART2</accession>
    <accession>C8VL04</accession>
    <name>Q5ART2_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Catechol dioxygenase, putative (AFU_orthologue AFUA_2G02910)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ANIA_08998</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the intradiol ring-cleavage dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF84491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_682267.1">
        <property type="nucleotide sequence ID" value="XM_677175.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ART2"/>
    <dbReference type="STRING" id="227321.Q5ART2"/>
    <dbReference type="GeneID" id="2868290"/>
    <dbReference type="KEGG" id="ani:ANIA_08998"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN8998"/>
    <dbReference type="eggNOG" id="ENOG502QU2V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046727_1_1_1"/>
    <dbReference type="InParanoid" id="Q5ART2"/>
    <dbReference type="OMA" id="YAAYTEN"/>
    <dbReference type="OrthoDB" id="5238185at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018576">
        <property type="term" value="F:catechol 1,2-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009712">
        <property type="term" value="P:catechol-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03461">
        <property type="entry name" value="1_2-HQD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.130.10">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039390">
        <property type="entry name" value="1_2-HQD/HQD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007535">
        <property type="entry name" value="Catechol_dOase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000627">
        <property type="entry name" value="Intradiol_dOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015889">
        <property type="entry name" value="Intradiol_dOase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050770">
        <property type="entry name" value="Intradiol_RC_Dioxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33711">
        <property type="entry name" value="DIOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G02910)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33711:SF7">
        <property type="entry name" value="INTRADIOL RING-CLEAVAGE DIOXYGENASES DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00775">
        <property type="entry name" value="Dioxygenase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04444">
        <property type="entry name" value="Dioxygenase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49482">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Catechol dioxygenase N-terminal" evidence="8">
        <location>
            <begin position="23"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="Intradiol ring-cleavage dioxygenases" evidence="7">
        <location>
            <begin position="127"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBF84491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="297" mass="33298" checksum="9E55E8EE2E71AE4D" modified="2005-04-26" version="1">MTPHRFDPKFTDNVVNAMGKDVDPRFRQLMASLIRHVHDFARENELTVDEWMAGVQLMNWAGQMSTAKRNEGQMVCDVIGLESLVDEITFKLADEATDAPTATAILGPFFRADTPFRSNGESIVKTAPKEKDGKGEIAYMAGQVMDLVTKKPLVGAVVEVWQASTNGLYEQQDPEQEEFNLRGKFRTDENGRYSFYCLRPTPYPAPDDGPAGMLLKLMDRHVFRPAHIHIIATHDGYRPLTTQIFDRQDPYLTSDAVFAVKESLIVDFIERKGDPQAGLELNFDVKLVPDGMKSNGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="101" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ARW0</accession>
    <accession>C8VL83</accession>
    <name>Q5ARW0_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Oxidoreductase CipA-like, putative (AFU_orthologue AFUA_1G12460)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ANIA_08970</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family. Isoflavone reductase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF84544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_682239.1">
        <property type="nucleotide sequence ID" value="XM_677147.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ARW0"/>
    <dbReference type="SMR" id="Q5ARW0"/>
    <dbReference type="GeneID" id="2868145"/>
    <dbReference type="KEGG" id="ani:ANIA_08970"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN8970"/>
    <dbReference type="eggNOG" id="ENOG502SHNB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044876_3_2_1"/>
    <dbReference type="InParanoid" id="Q5ARW0"/>
    <dbReference type="OMA" id="PLNALWI"/>
    <dbReference type="OrthoDB" id="9974981at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF1">
        <property type="entry name" value="CIPA-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12460)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="4">
        <location>
            <begin position="12"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBF84544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="297" mass="32586" checksum="6E6F3A10920961F8" modified="2005-04-26" version="1">MTIFRRVALIGRGSLGTVLLDELLNSNFTVTVLTRSASSASSLPPGADIKQVDYSSAESLKTALAGHDIVISTLSPSAIPLQKQVIDAAIAVGVKRFIPAEYGAMTSDPVGRKLPFHKDAIEIHEFLRETVASGLIEYTVFGVGVLTELLFTTTLVVDLEHREVKLFDGGIHSFSTSRLETVARAVVASLHKPDETRNRVIRVHDAVLTQRQVLDMAKGWTPTLEWREVYVDAQAEVDRGLKQLEKEFSPALVPGVFAAALMSGRYGAEYKEVDNELLGLGFMDKREINDFGKKFTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ATL6</accession>
    <accession>C8VE58</accession>
    <name>Q5ATL6_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nephrocystin 3-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_08364</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF80389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_681633.1">
        <property type="nucleotide sequence ID" value="XM_676541.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ATL6"/>
    <dbReference type="GeneID" id="2868680"/>
    <dbReference type="KEGG" id="ani:ANIA_08364"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN8364"/>
    <dbReference type="eggNOG" id="KOG4177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_990460_0_0_1"/>
    <dbReference type="InParanoid" id="Q5ATL6"/>
    <dbReference type="OMA" id="WISTIDF"/>
    <dbReference type="OrthoDB" id="1577640at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF15">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="2">
        <location>
            <begin position="98"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF80389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="232" mass="26516" checksum="6956B49144108D7F" modified="2005-04-26" version="1">MIHYDAIGSGNTIMKNPFWRDELASKTDILCFDTGAAGLKDQFPCLVKRGISDHADSHSTDEWRGLEAEIEICEVLDWHTNDDYSVQQNDNLEPREPGTGGWFLQTLEFEDWVESPGKLLFYPSIAGAGKTTIASIVVDYPQEEYENDPNCSVAYIYFNHMRLEKQTIRHLLATLLRQLSENATHLHSLIRYLYQKHRKERKRPSVNALVQGLDESAGLQSRQFIVVDALDE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2010-06-15" modified="2026-01-28" version="101" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AU92</accession>
    <accession>C8V6Q1</accession>
    <accession>Q1HFQ9</accession>
    <name>AGALC_EMENI</name>
    <protein>
        <recommendedName>
            <fullName>Alpha-galactosidase C</fullName>
            <ecNumber>3.2.1.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Melibiase C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">aglC</name>
        <name type="ORF">AN8138</name>
    </gene>
    <organism>
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="11417" last="11422">
            <title>Development and application of a suite of polysaccharide-degrading enzymes for analyzing plant cell walls.</title>
            <authorList>
                <person name="Bauer S."/>
                <person name="Vasu P."/>
                <person name="Persson S."/>
                <person name="Mort A.J."/>
                <person name="Somerville C.R."/>
            </authorList>
            <dbReference type="PubMed" id="16844780"/>
            <dbReference type="DOI" id="10.1073/pnas.0604632103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA]</scope>
        <scope>FUNCTION</scope>
        <scope>BIOPHYSICOCHEMICAL PROPERTIES</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Hydrolyzes a variety of simple alpha-D-galactoside as well as more complex molecules such as oligosaccharides and polysaccharides. Active on paranitrophenyl-alpha-galactoside, raffinose, locust bean gum and gum guar.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.</text>
            <dbReference type="EC" id="3.2.1.22"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="biophysicochemical properties">
        <phDependence>
            <text evidence="4">Optimum pH is 3.5.</text>
        </phDependence>
        <temperatureDependence>
            <text evidence="4">Optimum temperature is 52 degrees Celsius.</text>
        </temperatureDependence>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the glycosyl hydrolase 36 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.22"/>
    <dbReference type="EMBL" id="DQ490515">
        <property type="protein sequence ID" value="ABF50891.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AACD01000140">
        <property type="protein sequence ID" value="EAA58775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF73961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_681407.1">
        <property type="nucleotide sequence ID" value="XM_676315.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AU92"/>
    <dbReference type="SMR" id="Q5AU92"/>
    <dbReference type="STRING" id="227321.Q5AU92"/>
    <dbReference type="CAZy" id="GH36">
        <property type="family name" value="Glycoside Hydrolase Family 36"/>
    </dbReference>
    <dbReference type="GlyCosmos" id="Q5AU92">
        <property type="glycosylation" value="8 sites, No reported glycans"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CBF73961">
        <property type="protein sequence ID" value="CBF73961"/>
        <property type="gene ID" value="ANIA_08138"/>
    </dbReference>
    <dbReference type="KEGG" id="ani:ANIA_08138"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN8138"/>
    <dbReference type="eggNOG" id="ENOG502QWG1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009640_2_1_1"/>
    <dbReference type="InParanoid" id="Q5AU92"/>
    <dbReference type="OMA" id="MSQQFHR"/>
    <dbReference type="OrthoDB" id="5795902at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004557">
        <property type="term" value="F:alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046355">
        <property type="term" value="P:mannan catabolic process"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="CDD" id="cd14791">
        <property type="entry name" value="GH36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1180:FF:000028">
        <property type="entry name" value="Alpha-galactosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.60:FF:000001">
        <property type="entry name" value="Alpha-galactosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000118">
        <property type="entry name" value="Alpha-galactosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.60">
        <property type="entry name" value="alpha-galactosidase from lactobacil brevis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038417">
        <property type="entry name" value="Alpga-gal_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050985">
        <property type="entry name" value="Alpha-glycosidase_related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002252">
        <property type="entry name" value="Glyco_hydro_36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031705">
        <property type="entry name" value="Glyco_hydro_36_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031704">
        <property type="entry name" value="Glyco_hydro_36_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43053:SF3">
        <property type="entry name" value="ALPHA-GALACTOSIDASE C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43053">
        <property type="entry name" value="GLYCOSIDASE FAMILY 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16874">
        <property type="entry name" value="Glyco_hydro_36C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16875">
        <property type="entry name" value="Glyco_hydro_36N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02065">
        <property type="entry name" value="Melibiase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005536">
        <property type="entry name" value="Agal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00743">
        <property type="entry name" value="GLHYDRLASE36"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0326">Glycosidase</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-0624">Polysaccharide degradation</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000395067" description="Alpha-galactosidase C">
        <location>
            <begin position="27"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="511"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="573"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="162"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="366"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="428"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="432"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="Q9ALJ4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3"/>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="16844780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <sequence length="750" mass="82202" checksum="826605C1031BE18A" modified="2005-04-26" version="1" precursor="true">MFRSTATVAAATAMGLLTATGHGSLAIAQGTTGSNAVVVDGTNFALNGASMSYVFHANSTTGDLVSDHFGATISGAIPAPKEPAVNGWVGMPGRIRREFPDQGRGDFRIPAVRIRQTAGYTVSDLQYQGHEVVDGKPALPGLPATFGEAGDVTTLVVHLYDNYSAVAADLSYSVFPEFDAVVRSVNVTNKGKGNITIENLASLSVDFPLEDLDLVSLRGDWAREANRERRRVEYGIQGFGSSTGYSSHLHNPFFALVHPSTTESQGEAWGFNLVYTGSFSAQVEKGSQGLTRALIGFNPDQLSWNLGPGETLTSPECVSVYSKDGIGGMSRKFHRLYRKHLIRSKFATSDRPPLLNSWEGVYFDFNQSSIETLAEQSAALGIRLFVMDDGWFGDKYPRTSDNAGLGDWTPNPDRFPNGLEPVVEEITNLTVNDTSAEKLRFGIWVEPEMVNPNSSLYREHPDWALHAGAYARTERRNQLVLNLALPEVQEYIIDFMTDLLNSADISYIKWDNNRGIHEAPSPSTDHEYMLGVYRVFDTLTARFPDVLWEGCASGGGRFDAGVLHYFPQIWTSDNTDGVDRVTIQFGTSLAYPPSAMGAHLSAVPNHQTGRTVPLEFRAHVAMMGGSFGLELDPATLQDDPDVPELIQMAEKVNPLVLNGDLYRLRLPEESQWPAALFVAEDGSQAVLFYFQLSPNVNHAAPWVRLQGLDPEASYTVDGDKTYTGATLMNLGLQYTFDTEYGSKVVFLERQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AUN4</accession>
    <accession>C8V5L7</accession>
    <name>Q5AUN4_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_07996</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF73672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_681265.1">
        <property type="nucleotide sequence ID" value="XM_676173.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AUN4"/>
    <dbReference type="STRING" id="227321.Q5AUN4"/>
    <dbReference type="GeneID" id="2869331"/>
    <dbReference type="KEGG" id="ani:ANIA_07996"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN7996"/>
    <dbReference type="eggNOG" id="ENOG502SC0Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055842_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AUN4"/>
    <dbReference type="OMA" id="WESGSAH"/>
    <dbReference type="OrthoDB" id="425602at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="83"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="305"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF73672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="334" mass="36247" checksum="23B1CBF127CE0992" modified="2005-04-26" version="1">MAALTMSPASVRQPFAPLDAPRMRSILRSKMNVLNKQNGNMFLGKKQPLAEFDSENIDPTAPKPTLKSTKRKRAADDEDDLAPTKSPMKPTKSSSLGFTIFEDSVAPSTPKKTTQLTPKSAPLKPAGRSPQLKATKPFSRRATISKSRPESARKGIGRPFSLAAVLSTGKPKQKSQPAPAPKMPASWSFEIYVDSEQEEMTNLMQHSTCVLDISDDEGKDESQSDHRGKENIPPADLGISLPRSQQESPAVAVPKSDTVDEPRSPLGELNAADFYGEDCHAFSYAVVYDDDEDEEAPVDKKNASRSRLSSMSSIESVLEASPVKAVEETIGDST</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="111" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AUQ3</accession>
    <accession>C8V5F5</accession>
    <name>Q5AUQ3_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ribonuclease H</fullName>
            <ecNumber evidence="3">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ANIA_07977</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNase H family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="3"/>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF73635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_681246.1">
        <property type="nucleotide sequence ID" value="XM_676154.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AUQ3"/>
    <dbReference type="GeneID" id="2869283"/>
    <dbReference type="KEGG" id="ani:ANIA_07977"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN7977"/>
    <dbReference type="HOGENOM" id="CLU_909203_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AUQ3"/>
    <dbReference type="OrthoDB" id="4135672at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd09276">
        <property type="entry name" value="Rnase_HI_RT_non_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000101">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046670">
        <property type="entry name" value="DUF6540"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050092">
        <property type="entry name" value="RNase_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10642">
        <property type="entry name" value="RIBONUCLEASE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10642:SF26">
        <property type="entry name" value="RIBONUCLEASE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20174">
        <property type="entry name" value="DUF6540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="8">
        <location>
            <begin position="12"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBF73635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="306" mass="32856" checksum="CB1B00E57BCF1889" modified="2005-04-26" version="1">MLPTDNKGYSPAPLQISVYLDGSRTSQGAGYGYAIYFGPILMSKGHGPAGPRTEVYDAEIIGAVEGLRAALGQPCVGYSTQLVILLDNLAAASLLASYRPTPHRHGLSETFSQLAAQWMESPSILTMQRKPLQVRWIPGHSGIAGNELADKLAKLGPEYQTPIQKKAAPASTSCPGGYLADSSPPVQATETLRHTTSASTTQTTWRAALVSGHVFQVVGDIQNGMTHGHKPAKKPEESATYQGKVLIGKISAANYSRVKPICDSIPPPKKQFEGPRRLYPEEPIRRCQEWTKEAVEALAAAGVLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AUR5</accession>
    <accession>C8V5E2</accession>
    <name>Q5AUR5_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ANIA_07965</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF73611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_681234.1">
        <property type="nucleotide sequence ID" value="XM_676142.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AUR5"/>
    <dbReference type="GeneID" id="2869305"/>
    <dbReference type="KEGG" id="ani:ANIA_07965"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN7965"/>
    <dbReference type="HOGENOM" id="CLU_1835153_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AUR5"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF73611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="140" mass="15296" checksum="1EB41332A1A07B4C" modified="2005-04-26" version="1">MIKSHLDCGALMQGNKDAAISIHKGTHPTSTLDAGLSYLKNSSCITQFSIRRHCSIWLLCERNMETQNVVLKQNWESGNRFNIAALRLFTSSTTSMPNFLHTICALPLFQYPSGQATIAFPGTRAHNPSSNKLIGACVAG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2016-11-30" modified="2025-04-09" version="138" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AUX1</accession>
    <accession>C8V4V0</accession>
    <name>ORSA_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Orsellinic acid synthase</fullName>
            <shortName evidence="13">OAS</shortName>
            <ecNumber evidence="9 10">2.3.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Non-reducing polyketide synthase orsA</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Orsellinic acid/F9775 biosynthesis cluster protein A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">orsA</name>
        <name type="ORF">AN7909</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2009" name="Nat. Chem. Biol." volume="5" first="462" last="464">
            <title>Chromatin-level regulation of biosynthetic gene clusters.</title>
            <authorList>
                <person name="Bok J.W."/>
                <person name="Chiang Y.M."/>
                <person name="Szewczyk E."/>
                <person name="Reyes-Dominguez Y."/>
                <person name="Davidson A.D."/>
                <person name="Sanchez J.F."/>
                <person name="Lo H.C."/>
                <person name="Watanabe K."/>
                <person name="Strauss J."/>
                <person name="Oakley B.R."/>
                <person name="Wang C.C."/>
                <person name="Keller N.P."/>
            </authorList>
            <dbReference type="PubMed" id="19448638"/>
            <dbReference type="DOI" id="10.1038/nchembio.177"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2009" name="Proc. Natl. Acad. Sci. U.S.A." volume="106" first="14558" last="14563">
            <title>Intimate bacterial-fungal interaction triggers biosynthesis of archetypal polyketides in Aspergillus nidulans.</title>
            <authorList>
                <person name="Schroeckh V."/>
                <person name="Scherlach K."/>
                <person name="Nuetzmann H.W."/>
                <person name="Shelest E."/>
                <person name="Schmidt-Heck W."/>
                <person name="Schuemann J."/>
                <person name="Martin K."/>
                <person name="Hertweck C."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="19666480"/>
            <dbReference type="DOI" id="10.1073/pnas.0901870106"/>
        </citation>
        <scope>IDENTIFICATION OF THE ORS CLUSTER</scope>
        <scope>INDUCTION</scope>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>PATHWAY</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2010" name="Mol. Biosyst." volume="6" first="587" last="593">
            <title>Molecular genetic analysis of the orsellinic acid/F9775 gene cluster of Aspergillus nidulans.</title>
            <authorList>
                <person name="Sanchez J.F."/>
                <person name="Chiang Y.M."/>
                <person name="Szewczyk E."/>
                <person name="Davidson A.D."/>
                <person name="Ahuja M."/>
                <person name="Elizabeth Oakley C."/>
                <person name="Woo Bok J."/>
                <person name="Keller N."/>
                <person name="Oakley B.R."/>
                <person name="Wang C.C."/>
            </authorList>
            <dbReference type="PubMed" id="20174687"/>
            <dbReference type="DOI" id="10.1039/b904541d"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>DOMAIN</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>PATHWAY</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2013" name="Appl. Environ. Microbiol." volume="79" first="6102" last="6109">
            <title>Distinct amino acids of histone H3 control secondary metabolism in Aspergillus nidulans.</title>
            <authorList>
                <person name="Nuetzmann H.W."/>
                <person name="Fischer J."/>
                <person name="Scherlach K."/>
                <person name="Hertweck C."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="23892751"/>
            <dbReference type="DOI" id="10.1128/AEM.01578-13"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2013" name="Mol. Microbiol." volume="89" first="963" last="974">
            <title>VeA and MvlA repression of the cryptic orsellinic acid gene cluster in Aspergillus nidulans involves histone 3 acetylation.</title>
            <authorList>
                <person name="Bok J.W."/>
                <person name="Soukup A.A."/>
                <person name="Chadwick E."/>
                <person name="Chiang Y.M."/>
                <person name="Wang C.C."/>
                <person name="Keller N.P."/>
            </authorList>
            <dbReference type="PubMed" id="23841751"/>
            <dbReference type="DOI" id="10.1111/mmi.12326"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="9 10">Non-reducing polyketide synthase; part of the gene cluster that mediates the biosynthesis of orsellinic acid, as well as of the cathepsin K inhibitors F9775 A and F9775 B (PubMed:19666480, PubMed:20174687). The non-reducing polyketide synthase orsA produces orsellinic acid by condensing acetyl-CoA with 3 malonyl-CoA units (PubMed:19666480, PubMed:20174687). Further modifications by the decarboxylase orsB and the tyrosinase-like protein orsC lead to the production of F9775 A and F9775 B (PubMed:20174687). The functions of orsD and orsE remain unclear since only orsB and orsC are required to convert orsellinic acid into F9775 A and F9775 B (PubMed:20174687).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>3 malonyl-CoA + acetyl-CoA + 2 H(+) = orsellinate + 3 CO2 + 4 CoA</text>
            <dbReference type="Rhea" id="RHEA:62972"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16162"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9 10">
            <dbReference type="Rhea" id="RHEA:62973"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="9 10">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="induction">
        <text evidence="9 11 12">Expression is induced by an intimate physical interaction of the fungal mycelia with the bacterium Streptomyces hygroscopicus (PubMed:19666480). Expression is repressed by VeA and MvlA via histone 3 acetylation by the SAGA/ADA complex (PubMed:23841751, PubMed:23892751).</text>
    </comment>
    <comment type="domain">
        <text evidence="2">Multidomain protein; including a starter unit:ACP transacylase (SAT) that selects the starter unit; a ketosynthase (KS) that catalyzes repeated decarboxylative condensation to elongate the polyketide backbone; a malonyl-CoA:ACP transacylase (MAT) that selects and transfers the extender unit malonyl-CoA; a product template (PT) domain that controls the immediate cyclization regioselectivity of the reactive polyketide backbone; and an acyl-carrier protein (ACP) that serves as the tether of the growing and completed polyketide via its phosphopantetheinyl arm.</text>
    </comment>
    <comment type="domain">
        <text evidence="1">The release of the polyketide chain from the non-reducing polyketide synthase is mediated by the thioesterase (TE) domain localized at the C-ter of the protein.</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="9 10">Abolishes the production of orsellinic acid, lecanoric acid and F-9775A/B (PubMed:19666480, PubMed:20174687).</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="9 10"/>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF73505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AACD01000135">
        <property type="protein sequence ID" value="EAA59563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_681178.1">
        <property type="nucleotide sequence ID" value="XM_676086.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AUX1"/>
    <dbReference type="SMR" id="Q5AUX1"/>
    <dbReference type="STRING" id="227321.Q5AUX1"/>
    <dbReference type="ESTHER" id="emeni-q5aux1">
        <property type="family name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CBF73505">
        <property type="protein sequence ID" value="CBF73505"/>
        <property type="gene ID" value="ANIA_07909"/>
    </dbReference>
    <dbReference type="KEGG" id="ani:ANIA_07909"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN7909"/>
    <dbReference type="eggNOG" id="KOG1202">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_6_4_1"/>
    <dbReference type="InParanoid" id="Q5AUX1"/>
    <dbReference type="OMA" id="EMAYHAL"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="BioCyc" id="MetaCyc:MONOMER-21843"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900557">
        <property type="term" value="P:emericellamide biosynthetic process"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900611">
        <property type="term" value="P:F-9775A biosynthetic process"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900614">
        <property type="term" value="P:F-9775B biosynthetic process"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900815">
        <property type="term" value="P:monodictyphenone biosynthetic process"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900584">
        <property type="term" value="P:o-orsellinic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0000303"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045461">
        <property type="term" value="P:sterigmatocystin biosynthetic process"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900590">
        <property type="term" value="P:violaceol I biosynthetic process"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900593">
        <property type="term" value="P:violaceol II biosynthetic process"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000146">
        <property type="entry name" value="Orsellinic acid synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.366.10:FF:000002">
        <property type="entry name" value="Probable polyketide synthase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030918">
        <property type="entry name" value="PT_fungal_PKS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032088">
        <property type="entry name" value="SAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR04532">
        <property type="entry name" value="PT_fungal_PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF37">
        <property type="entry name" value="SI:DKEY-61P9.11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22621">
        <property type="entry name" value="CurL-like_PKS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16073">
        <property type="entry name" value="SAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0511">Multifunctional enzyme</keyword>
    <keyword id="KW-0596">Phosphopantetheine</keyword>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000438572" description="Orsellinic acid synthase">
        <location>
            <begin position="1"/>
            <end position="2103"/>
        </location>
    </feature>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="5 15">
        <location>
            <begin position="348"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="6">
        <location>
            <begin position="1272"/>
            <end position="1582"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier 1" evidence="4">
        <location>
            <begin position="1640"/>
            <end position="1716"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier 2" evidence="4">
        <location>
            <begin position="1741"/>
            <end position="1815"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal acylcarrier protein transacylase domain (SAT)" evidence="3 15">
        <location>
            <begin position="17"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Malonyl-CoA:ACP transacylase (MAT) domain" evidence="3 15">
        <location>
            <begin position="881"/>
            <end position="1197"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="6">
        <location>
            <begin position="1272"/>
            <end position="1409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Product template (PT) domain" evidence="3 15">
        <location>
            <begin position="1303"/>
            <end position="1579"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="6">
        <location>
            <begin position="1433"/>
            <end position="1582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1592"/>
            <end position="1638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1722"/>
            <end position="1743"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1809"/>
            <end position="1838"/>
        </location>
    </feature>
    <feature type="region of interest" description="Thioesterase (TE) domain" evidence="3 15">
        <location>
            <begin position="1849"/>
            <end position="2082"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1594"/>
            <end position="1603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1617"/>
            <end position="1631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1810"/>
            <end position="1819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1823"/>
            <end position="1836"/>
        </location>
    </feature>
    <feature type="active site" description="For beta-ketoacyl synthase activity" evidence="5">
        <location>
            <position position="525"/>
        </location>
    </feature>
    <feature type="active site" description="For beta-ketoacyl synthase activity" evidence="5">
        <location>
            <position position="660"/>
        </location>
    </feature>
    <feature type="active site" description="For beta-ketoacyl synthase activity" evidence="5">
        <location>
            <position position="702"/>
        </location>
    </feature>
    <feature type="active site" description="For acyl/malonyl transferase activity" evidence="7">
        <location>
            <position position="973"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="6">
        <location>
            <position position="1304"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="6">
        <location>
            <position position="1493"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="1676"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="1775"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="Q5ATJ7"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="Q5B0D0"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3"/>
    <evidence type="ECO:0000255" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="9">
        <source>
            <dbReference type="PubMed" id="19666480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="10">
        <source>
            <dbReference type="PubMed" id="20174687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="11">
        <source>
            <dbReference type="PubMed" id="23841751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="12">
        <source>
            <dbReference type="PubMed" id="23892751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="13">
        <source>
            <dbReference type="PubMed" id="19666480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="14">
        <source>
            <dbReference type="PubMed" id="20174687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="15">
        <source>
            <dbReference type="PubMed" id="20174687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EAA59563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000005890"/>
        </source>
    </evidence>
    <sequence length="2103" mass="225849" checksum="24941E20ABF74DB1" modified="2005-04-26" version="1">MAPNHVLFFPQERVTFDAVHDLNVRSKSRRRLQSLLAAASNVVQHWTASLDGLERADIGSFEDLVELAERQTTQTRGSIVADLVLLTTVQIGQLLVLAEDDPAILSGHAGARAIPMGFGAGLVAAGVAAAATSADGIVNLGLEAVSVAFRLGVELQRRGKDIEDSNGPWAQVISSATTIADLEQALDRINASLRPINQAYIGEVMTESTVVFGPPSTLDALAKRPELAHATITSPASALAQVPLHGAHLPPISATMIAASSSQQATELWKLAVEEVANKPIDVHQAVTALIHDLHRANITDIVLTAIGASTETSGIQSLLEKNGLAVELGQLSPTPRPYGNDLDSIPADAIAVVGMSGRFPNSDTLDEFWRLLETATTTHQVIPESRFNVDDFYDPTRAKHNALLARYGCFLKNPGDFDHRLFNISPREAMQMDPVQRMLLMTTYEALEMAGYSPPTPAAPGDSEQAPPRIATYFGQTIDDWKSINDQQGIDTHYLPGVNRGFAPGRLSHFFQWAGGFYSIDTGCSSSATALCLARDALTAGKYDAAVVGGGTLLTAPEWFAGLSQGGFLSPTGACKTYSDSADGYCRGEGVGVVILKRLADAVRSKDNVIAVIAGASRNCNAGAGSITYPGEKAQGALYRRVMRQAAVRPEQVDVVEMHGTGTQAGDRVETHAVQSVFAPSNGNQREKPLIVGALKANIGHSEAAAGIISLMKAILILQHDKIPAQPNQPIKMNPYLEPLIGKQIQLANGQSWTRNGAEPRYIFVNNFDAAGGNVSMLLQDPPAFALPAPASGPGLRTHHVVVTSGRTATAHEANRKRLHAYLSAHPDTNLADLAYTTTARRIHNVHREAYVASSTSDLVRQLEKPLADKVESAPPPAVVFTFTGQGAQSLGMGGALYSTSPTFRRLLDSLQSICEVQGLPTKFLNAIRGSGAEGATVTEVDMQVATVALEIALARYWRSLGIRPTVLIGHSLGEYAALCVAGVLSASDALALAFRRATLIFTRCPPSEAAMLAVGLPMRTVQYRIRDSAATTGCEVCCVNGPSSTVVGGPVAAIQALDEYLKSDGKVSTTRLRVQHAFHTRQMDVLLDELEASAAQVPFHAPTLPVASTVLGRIVRPGEQGVFDANYLRRHTREPVAFLDAVRACETEGLIPDRSFAVEIGPHPICISLMATCLQSAKINAWPSLRRGGDDWQSVSSTLAAAHSAQLPVAWSEFHKDHLDTVRLISDLPTYAFDLKTFWHSYKTPAAAVSAASATPSTTGLSRLASTTLHAVEKLQREEGKILGTFTVDLSDPKLAKAICGHVVDESAICPASIFIDMAYTAAVFLEQENGAGAALNTYELSSLEMHSPLVLREDIEVLPQVWVEAVLDIKSNAVSVHFKGQTSKGAVGYGSATMRLGQPDSAVRRDWSRIQSLVRARVQTLNRSVRPREVHAMDTALFYKVFSEIVDYSAPYHAVQEAVIAADFHDAAVTLQLTPTADLGTFTSSPFAVDALVHVAGFLLNADVRRPKNEVHIANHIGSLRIVGDLSSPGPYHVYATIREQDQKAGTSLCDVYTTDSQDRLVAVCSDICFKKLERDFFALLTGATRGRSTKPVAAAPAKSMAKRARQLAPSPSPSSSSGSNTPMSRSPTPSSVSDMVDLGTELLQAVAEQTGVSVAEMKSSPGTTFTEFGVDSQMAISILANFQRTTAVELPAAFFTNFPTPADAEAELGGSALDDLEEDITKPTPSPEQTQARKQGPAPSQHLLSLVAQALGLEASDLTPSTTFDSVGMDSMLSIKITAAFHAKTGIELPAAFFSANPTVGAAQEALDDDAEEESAPAQTSTNPAKETTIDSSRQHKLDAAVSRASYIHLKALPKGRRIYALESPFLEQPELFDLSIEEMATIFLRTIRRIQPHGPYLIGGWSAGSMYAYEVAHRLTREGETIQALIILDMRAPSLIPTSIVTTDFVDKLGTFEGINRARDLPEDLSVKERAHLMATCRALSRYDAPAFPSDRQPKQVAVVWALLGLDNRPDAPIASMGRPGLDIGKSMYEMNLDEFERYFNSWFYGRRQQFGTNGWEDLLGDHIAVYTVNGDHFSMMCPPYASEVGDIVIETVTRAVE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2018-05-23" modified="2026-01-28" version="152" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AV01</accession>
    <accession>A0A1U8QZH1</accession>
    <accession>C8V3Y4</accession>
    <name>ATNG_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ABC transporter atnG</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Aspercryptin biosynthesis cluster protein G</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">atnG</name>
        <name type="ORF">ANIA_07879</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="E99" last="E107">
            <title>Accurate prediction of secondary metabolite gene clusters in filamentous fungi.</title>
            <authorList>
                <person name="Andersen M.R."/>
                <person name="Nielsen J.B."/>
                <person name="Klitgaard A."/>
                <person name="Petersen L.M."/>
                <person name="Zachariasen M."/>
                <person name="Hansen T.J."/>
                <person name="Blicher L.H."/>
                <person name="Gotfredsen C.H."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Mortensen U.H."/>
            </authorList>
            <dbReference type="PubMed" id="23248299"/>
            <dbReference type="DOI" id="10.1073/pnas.1205532110"/>
        </citation>
        <scope>IDENTIFICATION OF THE CLUSTER</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2016" name="ACS Chem. Biol." volume="11" first="2117" last="2123">
            <title>New aspercryptins, lipopeptide natural products, revealed by HDAC inhibition in Aspergillus nidulans.</title>
            <authorList>
                <person name="Henke M.T."/>
                <person name="Soukup A.A."/>
                <person name="Goering A.W."/>
                <person name="McClure R.A."/>
                <person name="Thomson R.J."/>
                <person name="Keller N.P."/>
                <person name="Kelleher N.L."/>
            </authorList>
            <dbReference type="PubMed" id="27310134"/>
            <dbReference type="DOI" id="10.1021/acschembio.6b00398"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2016" name="Angew. Chem. Int. Ed." volume="55" first="1662" last="1665">
            <title>Development of genetic dereplication strains in Aspergillus nidulans results in the discovery of aspercryptin.</title>
            <authorList>
                <person name="Chiang Y.M."/>
                <person name="Ahuja M."/>
                <person name="Oakley C.E."/>
                <person name="Entwistle R."/>
                <person name="Asokan A."/>
                <person name="Zutz C."/>
                <person name="Wang C.C."/>
                <person name="Oakley B.R."/>
            </authorList>
            <dbReference type="PubMed" id="26563584"/>
            <dbReference type="DOI" id="10.1002/anie.201507097"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="function">
        <text evidence="6 7 8">ABC transporter; part of the gene cluster that mediates the biosynthesis of aspercryptins, linear lipopeptides built from six amino acids including 2 highly unusual and nonproteogenic amino acids, 2-amino-octanoic acid (2aoa) and 2-amino-dodecanol (2adol) (PubMed:23248299, PubMed:26563584, PubMed:27310134).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="8">Expression is positively regulated by the aspercryptin cluser-specific transcription factor atnN (PubMed:27310134).</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="7">Does not alter the yield of aspercryptin significantly (PubMed:26563584).</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF73441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AACD01000135">
        <property type="protein sequence ID" value="EAA59533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_681148.1">
        <property type="nucleotide sequence ID" value="XM_676056.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AV01"/>
    <dbReference type="SMR" id="Q5AV01"/>
    <dbReference type="STRING" id="227321.Q5AV01"/>
    <dbReference type="GlyCosmos" id="Q5AV01">
        <property type="glycosylation" value="7 sites, No reported glycans"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CBF73441">
        <property type="protein sequence ID" value="CBF73441"/>
        <property type="gene ID" value="ANIA_07879"/>
    </dbReference>
    <dbReference type="GeneID" id="2869038"/>
    <dbReference type="KEGG" id="ani:ANIA_07879"/>
    <dbReference type="eggNOG" id="KOG0054">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_27_5_1"/>
    <dbReference type="InParanoid" id="Q5AV01"/>
    <dbReference type="OMA" id="VWALPRI"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd18579">
        <property type="entry name" value="ABC_6TM_ABCC_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18580">
        <property type="entry name" value="ABC_6TM_ABCC_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000055">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000066">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000838">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001854">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044746">
        <property type="entry name" value="ABCC_6TM_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044726">
        <property type="entry name" value="ABCC_6TM_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056227">
        <property type="entry name" value="TMD0_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF399">
        <property type="entry name" value="ABC TRANSPORTER ATNG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24357">
        <property type="entry name" value="TMD0_ABC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000444136" description="ABC transporter atnG">
        <location>
            <begin position="1"/>
            <end position="1557"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="256"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1 3">
        <location>
            <begin position="311"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1 3">
        <location>
            <begin position="385"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1 3">
        <location>
            <begin position="412"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1 3">
        <location>
            <begin position="490"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1 3">
        <location>
            <begin position="531"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1 3">
        <location>
            <begin position="882"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1 3">
        <location>
            <begin position="921"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1 3">
        <location>
            <begin position="996"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1 3">
        <location>
            <begin position="1020"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1 3">
        <location>
            <begin position="1105"/>
            <end position="1125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1 3">
        <location>
            <begin position="1135"/>
            <end position="1155"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1 1" evidence="3">
        <location>
            <begin position="279"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter 1" evidence="2">
        <location>
            <begin position="593"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1 2" evidence="3">
        <location>
            <begin position="882"/>
            <end position="1162"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter 2" evidence="2">
        <location>
            <begin position="1199"/>
            <end position="1431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1439"/>
            <end position="1464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1503"/>
            <end position="1557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1507"/>
            <end position="1522"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="625"/>
            <end position="632"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="1233"/>
            <end position="1240"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="4">
        <location>
            <position position="202"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="4">
        <location>
            <position position="249"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="4">
        <location>
            <position position="667"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="4">
        <location>
            <position position="916"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="4">
        <location>
            <position position="1132"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="4">
        <location>
            <position position="1203"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="4">
        <location>
            <position position="1218"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="6">
        <source>
            <dbReference type="PubMed" id="23248299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="7">
        <source>
            <dbReference type="PubMed" id="26563584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="8">
        <source>
            <dbReference type="PubMed" id="27310134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="9">
        <source>
            <dbReference type="PubMed" id="26563584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="10"/>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CBF73441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="1557" mass="173274" checksum="1EB7747106957C5A" modified="2005-04-26" version="1">MAGSCTIDEHNHFGPIVGDACYGGLDFTLYFEEAFLSIFPAATLILAATVRCFLVRSASLKVRGGWLHTLKLLLLAPYSISQLLLLAFWMRSGTPKTDLTIASTVLRFIATLPCGYLIHLQHHRSLRPSKIISIYFLLTLLFDIPLARTIWTIQGLRTVSAIFIAGTVVKALLLILETWEKRRLVRPMYASPAPEDWTGVINRSLFWWINPLLFRGARTSLSVGDLFHLESCMLPDPDGKHRVVMHWENVTNKDKAGAMVVPIAKAFKWDLLAGVFPRLCQSGFIISQPFLVRATVELFVYRDRPDSRSKATLLIGAYALVYGGIAIATATAQHKTYRVITMMRAALVDMIFEKSTAINAHKNDDSAALTLMSTDIERITHCGRYIHDTWASLIEIGIALYLLYNELDTAGIAPIIIAFGCTVTAMKIAMMAGERQNLWIEAIQKRVAITAEMLGSMKGVKISGLTDLLFNKIQALREHEILASQKFRSLLIAVVGLSNFNTLMTPIVSFTIYAMGSGDAPNEILGSARALTSLTLFNLFAVFIGTLVESISETAMALECLDRIRNYLAQEAHQDPREVNSSPVTEKTPCIEAFEVDVGWKNGDESILHRLSYRIERHSLTMIVGAVGCGKTTLVKAMLGEVNCLTGKMKVNCDRMAYCGQDAWLTNGSIRENILGGSPYDPPWYSTVVAACGLEKDFTELTAGDQTAVGSKGVSLSGGQKQRLGSLDVLTRAQALARALYSGVETILLDDALSGLDPVTDEHIFTQVLGPNGLARKQHLTVVMVTHAVHRLPYADHIIALNTDGTILVQGTFDDCCKRLDYIQGFAIAQPPAIQMKSAMPKAVEVTKAAPYSDEAISDARRSSDYQTYLYYLTTVPWHNWLVYFGLMAIFVFLQAFPTVWVTWWARDNDAQPNKNRSMRIGVYWMFGVLGACFLLATACFYMLKIVAKTASVIHSRLLRTVVNAPMSFFASTDSGTTLNRFSQDLELIDMELPLAVLQTCLALFLCVAQLIIIAVSARYITATIPLCVLVYCIIGTFYMRTSRQLRIMEIEAKSPLFSNFMELLNGLITIRAFNWAEQYKLRNRALLAESQRPYYLLYAVQRWLSLVLDMTVAGFVLVLMGIAVGTMHSTNASSLGLALVNVVSLSASVKALITDWTVLETSLGAVTRVKHFAESTESEDMVQERDLPPEDWTSRGTVEYKNVSAFYRDPSKPVLKNLSFRVHKGEKVAIVGRSGSGKSTLVSALFRMIELCEGTISVDGIDITTLRRQAIRSAIIGLPQDPLLLEGSTIRENVDPFDYCPDEAVINTLKRVGLWEILESKDGLETIASPELFSHGQKQLLCMAKAMLRHGNIIVFDEATSGVDPETDEMMQELIRSCFAQHTVLTVTHRLDTIIDYDRVLVMDNGILLESDPPRTLLSRPSVFRELYKSSRGWEEYERQERAEAEARRRERVEKERAEEELRGRRGLISEKEEPETVSAIREHWNVVNQLFGGIIPRAVPRTRSRSRDHSAERRESKRYSGGDWTGEGDGDGGDGGLGRRDTRRHLTGLAARGLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AWE6</accession>
    <accession>C8VCG1</accession>
    <name>Q5AWE6_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_07384</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF78490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_680653.1">
        <property type="nucleotide sequence ID" value="XM_675561.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AWE6"/>
    <dbReference type="STRING" id="227321.Q5AWE6"/>
    <dbReference type="GeneID" id="2869840"/>
    <dbReference type="KEGG" id="ani:ANIA_07384"/>
    <dbReference type="HOGENOM" id="CLU_089018_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AWE6"/>
    <dbReference type="OMA" id="WHAVSYE"/>
    <dbReference type="OrthoDB" id="3552888at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35605">
        <property type="entry name" value="ECP2 EFFECTOR PROTEIN DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35605:SF1">
        <property type="entry name" value="ECP2 EFFECTOR PROTEIN DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010310479" evidence="2">
        <location>
            <begin position="19"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF78490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="214" mass="22884" checksum="347A4FA3BFB43659" modified="2005-04-26" version="1">MKFPAAVALFSTISAVAAAYVGSPSAYTYTSVPEFEIEVSPNKTIIARGTIEQIREQALAHNPNWDEEYYAPAQKLAEERYQLVPAGADANSTGSTPSLEKRRAEDFDSLRITCGRPWHAVSYEGALKEALRLYGVKGTPQNGPGPGNCGRVGCSYGTAIIWCNDDTETKTLSSFDEIADGAFAIMQKCAHDKHGEGTKAQSTGSTAPDAATLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AWJ7</accession>
    <accession>C8VCM0</accession>
    <name>Q5AWJ7_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ANIA_07333</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF78599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_680602.1">
        <property type="nucleotide sequence ID" value="XM_675510.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AWJ7"/>
    <dbReference type="GeneID" id="2870009"/>
    <dbReference type="KEGG" id="ani:ANIA_07333"/>
    <dbReference type="HOGENOM" id="CLU_2320350_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AWJ7"/>
    <dbReference type="OrthoDB" id="2968323at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF78599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="99" mass="11137" checksum="30F99254F32FD534" modified="2005-04-26" version="1">MSYCSGERTGDLDRRKKALSCRFGDRLSGVKGYNLYYAIETIPGASTAEVVGDVPANVKNTVMRRFIIGPVAERADWNKERAAMDRDRHISSRVQMDHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="130" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AWK5</accession>
    <accession>C8VCM8</accession>
    <name>Q5AWK5_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">DNA polymerase</fullName>
            <ecNumber evidence="20">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">ANIA_07325</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="26" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="26">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 20">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 20">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 20">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="20"/>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF78614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_680594.1">
        <property type="nucleotide sequence ID" value="XM_675502.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AWK5"/>
    <dbReference type="FunCoup" id="Q5AWK5">
        <property type="interactions" value="751"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5AWK5"/>
    <dbReference type="GeneID" id="2870046"/>
    <dbReference type="KEGG" id="ani:ANIA_07325"/>
    <dbReference type="eggNOG" id="KOG0969">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000203_2_0_1"/>
    <dbReference type="InParanoid" id="Q5AWK5"/>
    <dbReference type="OMA" id="CNNCRPR"/>
    <dbReference type="OrthoDB" id="2414538at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043625">
        <property type="term" value="C:delta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008296">
        <property type="term" value="F:3'-5'-DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006287">
        <property type="term" value="P:base-excision repair, gap-filling"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045004">
        <property type="term" value="P:DNA replication proofreading"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006297">
        <property type="term" value="P:nucleotide-excision repair, DNA gap filling"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd05777">
        <property type="entry name" value="DNA_polB_delta_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05533">
        <property type="entry name" value="POLBc_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.690:FF:000001">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.342.10:FF:000009">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000004">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.60">
        <property type="entry name" value="DNA polymerase family B, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.342.10">
        <property type="entry name" value="DNA Polymerase, chain B, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.690">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006172">
        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017964">
        <property type="entry name" value="DNA-dir_DNA_pol_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006133">
        <property type="entry name" value="DNA-dir_DNA_pol_B_exonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006134">
        <property type="entry name" value="DNA-dir_DNA_pol_B_multi_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042087">
        <property type="entry name" value="DNA_pol_B_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050240">
        <property type="entry name" value="DNA_pol_type-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025687">
        <property type="entry name" value="Znf-C4pol"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00592">
        <property type="entry name" value="pol2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10322">
        <property type="entry name" value="DNA POLYMERASE CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10322:SF23">
        <property type="entry name" value="DNA POLYMERASE DELTA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00136">
        <property type="entry name" value="DNA_pol_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03104">
        <property type="entry name" value="DNA_pol_B_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14260">
        <property type="entry name" value="zf-C4pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00106">
        <property type="entry name" value="DNAPOLB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00486">
        <property type="entry name" value="POLBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00116">
        <property type="entry name" value="DNA_POLYMERASE_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 20" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7 20" id="KW-0235">DNA replication</keyword>
    <keyword evidence="17 20" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="14 20" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="13" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15 20" id="KW-0408">Iron</keyword>
    <keyword evidence="16 20" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9 20" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6 20" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="18 20" id="KW-0539">Nucleus</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 20" id="KW-0808">Transferase</keyword>
    <keyword evidence="12 20" id="KW-0862">Zinc</keyword>
    <keyword evidence="10 20" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase family B exonuclease" evidence="23">
        <location>
            <begin position="241"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B multifunctional" evidence="22">
        <location>
            <begin position="536"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="domain" description="C4-type zinc-finger of DNA polymerase delta" evidence="24">
        <location>
            <begin position="946"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="75"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU000442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF00136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF03104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF14260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="CBF78614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="1044" mass="118608" checksum="83C484ADC4FF6E4C" modified="2005-04-26" version="1">MTEAIVMPQKRVLGDASNNPRGVVNSPDTIKKRKIDMQNTVKPSPRAPNGQRKVGSSQQKSQFEEEVLEKLTQDISGLKENNSEKDQQWERPPLGEFDPTKDNICFQQIDAEEGTTMGKPAIRLFGVTEAGQSVLLHVTGFQHYLYIAAPVGFTKEDCDPYRAFLESKIGQFPPVIQSVQITMRENIYGFQGNKKSYYLKITVTEPRHISKLRSALETKAQTVNYKGLWTNADGGILTFDNIQYLLRFMIDTDIQGMSWVEAPAGKYELIAPQDKVSNCQLEARIDYRSLISHAPVGDWAKMAPLRILSFDIECAGRKGIFPEPNHDPVIQIANVVTRYGESKPFIRNVFVMNTCSLIVNTQILEFQQEEKMLMAWRDFIQKVDPDVIIGYNIANFDFPYLLDRAKHLKCTNFPYWTRLNGMRSEAKDTNFSSKQMGNRDTKATNTNGRLQLDLLQLVQRDHNLRSYTLNSVSYEFLGEQKEDVHHTMITELYNGTPDSRRRLAVYCLKDAYLPQRLMDKLMCLVNYTEMARVTGVPFNFLLSRGQQVKFLSQLYRKALQQQLVIPNMKSTDEQDYEGATVIEPIRDYYDVPIATLDFASLYPSIIQAHNLCYTTLLNKNSVAGMKKDEDYIVTPNGDMFCTPKVRKGLLSQILEELLSARKKAKKELAQETDPFKKAVLNGRQLALKVSANSVYGLTGATVGKLPCLAIASSTTSYGRQMIEKTKQEVEARYTIANGYSHDAKVIYGDTDSVMVKFGVTELEEAMKLGQEASEYVSSKFIKPIKLEFEKVYFPYLLINKKRYAGLYWTNPKKYDKMDTKGIETVRRDNCLLVQNVIETVLHKILIDRDVEAAQEYVKDTISDLLQNKIDMSKLVITKALTKDSYTAKQAHVELAERMRKRDAGSAPTLGDRVAYVIVKGTAHEVHRHSAPTMGGLMKFTKKTQTCLGCKKPLTGKDVMAGAVCESCRPRLGELYTKSMNKMSDLEVRFGRLWTQCQRCQGSLHCEVICSSRDCPIFYMRMKAKKDVEDAQKELARFDFDAGAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AWL3</accession>
    <accession>C8VCN6</accession>
    <name>Q5AWL3_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ANIA_07317</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF78629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_680586.1">
        <property type="nucleotide sequence ID" value="XM_675494.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AWL3"/>
    <dbReference type="GeneID" id="2870040"/>
    <dbReference type="KEGG" id="ani:ANIA_07317"/>
    <dbReference type="eggNOG" id="ENOG502S2WG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051062_1_0_1"/>
    <dbReference type="InParanoid" id="Q5AWL3"/>
    <dbReference type="OMA" id="IYLWAWF"/>
    <dbReference type="OrthoDB" id="3648309at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015123">
        <property type="term" value="F:acetate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051633">
        <property type="entry name" value="AceTr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000791">
        <property type="entry name" value="Gpr1/Fun34/SatP-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF038013">
        <property type="entry name" value="AceTr_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31123">
        <property type="entry name" value="ACCUMULATION OF DYADS PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31123:SF1">
        <property type="entry name" value="ACCUMULATION OF DYADS PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01184">
        <property type="entry name" value="Gpr1_Fun34_YaaH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBF78629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="221" mass="23644" checksum="718E0DBC26D1E2B9" modified="2005-04-26" version="1">MADNTTDHASQLEKGMGGLPPTFVHLDRTHTAGGHVNDRTQPGLPVVHRTFANPSPLGLLSFATGLHARGVETPNVILGVLIFFGGLGQFLAAVMEFFTGNTFGATLWATYSAFNFSYAMIYIPGTGILAAYTDAETGALSPEFNQAIAIYLWAWFIVNTLYVVAAVRSSWVIFIDLAILSLGFLLLAVAYMTGDQAVMTAGYSVTMVTAALSSIPLEQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AWQ5</accession>
    <accession>C8VCT4</accession>
    <name>Q5AWQ5_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Xylosidase/glycosyl hydrolase, putative (AFU_orthologue AFUA_2G00930)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ANIA_07275</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF78719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_680544.1">
        <property type="nucleotide sequence ID" value="XM_675452.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AWQ5"/>
    <dbReference type="STRING" id="227321.Q5AWQ5"/>
    <dbReference type="CAZy" id="GH43">
        <property type="family name" value="Glycoside Hydrolase Family 43"/>
    </dbReference>
    <dbReference type="GeneID" id="2869896"/>
    <dbReference type="KEGG" id="ani:ANIA_07275"/>
    <dbReference type="eggNOG" id="ENOG502QVC0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016508_1_1_1"/>
    <dbReference type="InParanoid" id="Q5AWQ5"/>
    <dbReference type="OMA" id="DWFLHFQ"/>
    <dbReference type="OrthoDB" id="2139957at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09001">
        <property type="entry name" value="GH43_FsAxh1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041542">
        <property type="entry name" value="GH43_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051795">
        <property type="entry name" value="Glycosyl_Hydrlase_43"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42812">
        <property type="entry name" value="BETA-XYLOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42812:SF15">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G00930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17851">
        <property type="entry name" value="GH43_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Beta-xylosidase C-terminal Concanavalin A-like" evidence="6">
        <location>
            <begin position="307"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBF78719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="503" mass="55036" checksum="3175427035695AA2" modified="2005-04-26" version="1">MALPAVADISNPIFWADFADIDIIRVNDTFYYSASNMHYSPGAPILRSYDLLNWEFAGHSIPELTFGPNYYLDDGQQAYIKGTWASTLQYRPSTSTFYWMGCIDGTTYIYTAPDVGGPWTKASTINTCYYDCGLLITSDDKMYVAYGNNGISVAELSEDGLGEVSNQLVFPSDDAGYLEGSRFYERDGKFYIFTTHPANEEHVLMSNSGPLGPYERRLLISNAGTPVDGGGYPHQGGIVDTPNGDWYYMAFVDVYPGGRIPVLAPIIWNSDGWPYVELVDGAWSVTYDAPAINPPSTPVSSFEPYTDTFTVEKLSPQWEWNHNPDNAKWSIGEGVTLTTASLTNDLYAAKNTLTHRILGPKSTATIHLNISSMASGDRAGLALLRHHSAWIGVVNDGSTTRIAVTTGLEMDSEWNTVSTGTEVATAEYSNSEVWLRVEADISPGAGSGQFSFSGDGTTFTDLGGSYTLNNNWEFFMGYRFGIFNHATTELGGSVVLKSFALSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AWR7</accession>
    <accession>C8VCU7</accession>
    <name>Q5AWR7_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_07263</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF78743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_680532.1">
        <property type="nucleotide sequence ID" value="XM_675440.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AWR7"/>
    <dbReference type="GeneID" id="2869956"/>
    <dbReference type="KEGG" id="ani:ANIA_07263"/>
    <dbReference type="eggNOG" id="ENOG502SS54">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065414_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AWR7"/>
    <dbReference type="OMA" id="SHWIMAS"/>
    <dbReference type="OrthoDB" id="5410365at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF78743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="297" mass="32586" checksum="841AC935902FC37A" modified="2005-04-26" version="1">MAPQTILGHSFFSPKDVHLASLVPNIKDIDLDALESVIPLQDADFTIKEIDDFTSVFGSQIDNNFQALLSRIVSWTIKRTDEAKVTLTARKGRVYTLRKPSSWFRSLCEEPQVRTWLQEQIEDGNHDGVYFVVGLHTLFDAAISGGLALASDFGGGIAVSAPAMPAGTDNIAPLQDPGQLALSAGLERSRNTSHSCTAPGEQIFALRLKNVILRTWSTQDVANVRLEQHSHWIMASDNRGSDDDSSELLEAFLEGDSEGDDDIKEDSALDDPHDCQGQVIKTPIRAIVTRTKHFSSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="103" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AXR0</accession>
    <accession>C8V302</accession>
    <name>Q5AXR0_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SNF7 family protein (AFU_orthologue AFUA_5G13890)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_06920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
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                <person name="Hofmann G."/>
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                <person name="Horio T."/>
                <person name="Horiuchi H."/>
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                <person name="Liu B."/>
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                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
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                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
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            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
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        <property type="entry name" value="Snf7"/>
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            <begin position="190"/>
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        </location>
    </feature>
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        <location>
            <begin position="203"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
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    <sequence length="228" mass="25838" checksum="4209111E1CEC93BC" modified="2005-04-26" version="1">MESLKAVFFGPDPQTQMRKCNQLIRANTRQLDRDIAQLKALDGKTRQTIVNASKRAQRNPARAKQANLEAKMLARELVRVRRQTTRLTTSRAQLQSVQMQVNEAFAVRKIQGSLQKSTGIMKDVNTLIRLPQLSATMHQLATELVRAGIIEEMVDDAIPNNELLEDEEAEADEEVDKILQEILQGKLSQVDEVKPERPLEEPQQAEEEFEDQEAALAQMRGRLEALKS</sequence>
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<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
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    <accession>C8V1F9</accession>
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            <taxon>Eurotiomycetidae</taxon>
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        </lineage>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
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                <person name="Cornell M.J."/>
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            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
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    </reference>
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        <property type="component" value="Chromosome I"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </lineage>
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    <reference evidence="24" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
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                <person name="Freitag M."/>
                <person name="Selker E.U."/>
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                <person name="Penalva M.A."/>
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                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
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            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="24" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="24">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14 19">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
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        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ADP + phosphate + H(+)</text>
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            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:66133"/>
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    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 18">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="19">Membrane</location>
            <topology evidence="19">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 19">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
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        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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    <keyword evidence="12" id="KW-0445">Lipid transport</keyword>
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    <keyword evidence="13 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 17 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 19" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="507"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="539"/>
            <end position="558"/>
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    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1088"/>
            <end position="1111"/>
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    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1141"/>
            <end position="1163"/>
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    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1184"/>
            <end position="1210"/>
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    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1230"/>
            <end position="1251"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase N-terminal" evidence="21">
        <location>
            <begin position="173"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase C-terminal" evidence="22">
        <location>
            <begin position="1029"/>
            <end position="1257"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="71"/>
            <end position="128"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="329"/>
            <end position="365"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="431"/>
            <end position="457"/>
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    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="20">
        <location>
            <begin position="18"/>
            <end position="29"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="86"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="342"/>
            <end position="358"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="435"/>
            <end position="446"/>
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    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="16">
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            <position position="602"/>
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        <location>
            <position position="602"/>
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        <ligand>
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    <feature type="binding site" evidence="18">
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            <position position="602"/>
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        <location>
            <position position="603"/>
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    <feature type="binding site" evidence="18">
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    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="784"/>
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        <ligand>
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    <feature type="binding site" evidence="17">
        <location>
            <position position="813"/>
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        <location>
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        <ligand>
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        <ligand>
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    <feature type="binding site" evidence="18">
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        <ligand>
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        <source>
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        <source>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU362033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF16209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF16212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="CBF71100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="1265" mass="139635" checksum="81EBDC21D6146394" modified="2005-04-26" version="1">MPSSSEYLRAHDRASIESDNDDLDLEELDPSSAFNASRLSRDEPVQQRGHSGPGIALRNLRVGVGNRRLWKRSMSGSQGEDTAGLLEDREGERGLRPSHASSRPYTDDDAPLLDRRGSVRSLADGGRMPQRRSRLGWLKSSTLLGGLHGSTGGGKNTVDVVKPPRDVLVGQAQRAKYPPNIVSNAKYTPWSFLPRTLYNEFSFFFNIYFLLVALSQIIPVLRIGYMSTYIAPLAFVVSISLGKEALDDVGRRRRDAEANAEEFSVLALDKSGGSRAFPIAEDVGESVPVIIKKSRDLKVGDVLKVRKNQRLPADVVILKSVSNDATVARESQEAGASHNVDYATNGSSSSVPNQQPTISAGADQTDISSASDTFIRTDQLDGETDWKLRLPSVLSQALSLEDFTRLKITASGPDKRVNEFVGNIELLPPSGFYDPHVDKSEDRSQDADETEQNSSAPLTIDNTAWANTVLASNTITYAAIIYTGSQTRAALSTSPSRSKVGLLEYEINNLTKILCALTLTLSIILVALEGFQPTNDKEWYVAIMIYLILFSTIIPMSLRVNLDMAKSVYGRFIERDKDIPDTVVRTSTIPEDLGRIEYLLSDKTGTLTQNEMELKKIHVGTVSYANDAMEEVASYVRQSFSGNTLTSAAAAFGTQAGLAAAPRTRREIGSRVRDIVLALALCHNVTPTSDEEDGVKVTNYQASSPDEIAIVRYTEEVGLKVAYRDRRTIVLESTDTGNVVVRARILDIFPFTSDSKRMGIIVEFDKDKDVLNSPAEEEIWFYQKGADTVMTSIVAANDWLDEETANMAREGLRTLVVGRKRLSPLQYQEFASKYKQASLSLQGRDIGMQKVVNEYLEHDLELLGVTGVEDRLQRDVKPSLELLRNAGVKIWMLTGDKVETARCVAISAKLVARGQYIHTVAKVKDKSAAQEALDFLRNKTDCCLLIDGESLALMLNQFRSAFISVAVLLPAVIACRCSPTQKAEVADLIRLHTKKRVCCIGDGGNDVSMIQAADVGIGIVGKEGRQASLAADFSITQFHHITKLLVWHGRNSYKRSAKLAQFIMHRGLIISACQTMYSIASHFDPKGLFINWLMVGYATVYTNAPVFSLVLDRDVDEQLANLYPELYKELKTGRSLSYRSFFTWVLVSVYQGAVIQGLSQILLDTISGKRLISVSFTALVMNELLMVAIAVTTWHPVMIFCLLGTALVYAASVPFLGEYFDLKYVITLDWIWRVVAVTAVSVIPVWAAKLIKQSWNPPSYRKVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AZ15</accession>
    <accession>C8V067</accession>
    <name>Q5AZ15_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ANIA_06465</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF69414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_664069.1">
        <property type="nucleotide sequence ID" value="XM_658977.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AZ15"/>
    <dbReference type="GeneID" id="2871361"/>
    <dbReference type="KEGG" id="ani:ANIA_06465"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN6465"/>
    <dbReference type="HOGENOM" id="CLU_1001249_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AZ15"/>
    <dbReference type="OrthoDB" id="444631at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="22"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="155"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="156"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="193"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBF69414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="278" mass="30100" checksum="EEA14D522D485E91" modified="2005-04-26" version="1">MPGIPPHLAAAGCLESCPIPLAPFSSATGLYVLLLRVRTLWALNITAWKRIRLAAVFGLGILAFAASIVRLGMTHVLTSSPGATWNISSISKWAVICACLPVLPALLDRYREKNFGSSLNRLWSGGSRRSYSSAATESEVRFYCAYPDIISKSKGPISSTSDNQPPAISLERLSPQTEVNLHLTKKNSSPEAEPCRGDGDSGDYRAGRSATSTSSTSQVITPQRKTMMQARFTRGTGKSKSGCENLPTARSESHRNRNEFRSVQYSLSLAWGMDLDSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="106" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AZJ4</accession>
    <accession>C8V1A6</accession>
    <name>Q5AZJ4_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mannosyl-oligosaccharide glucosidase</fullName>
            <ecNumber evidence="1">3.2.1.106</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Glucosidase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ANIA_06286</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>N(4)-(alpha-D-Glc-(1-&gt;2)-alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] + H2O = N(4)-(alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] + beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:55988"/>
            <dbReference type="Rhea" id="RHEA-COMP:12806"/>
            <dbReference type="Rhea" id="RHEA-COMP:14355"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:59082"/>
            <dbReference type="ChEBI" id="CHEBI:132537"/>
            <dbReference type="EC" id="3.2.1.106"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Glycan metabolism; N-glycan degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 63 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.106" evidence="1"/>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF69778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_663890.1">
        <property type="nucleotide sequence ID" value="XM_658798.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AZJ4"/>
    <dbReference type="FunCoup" id="Q5AZJ4">
        <property type="interactions" value="163"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5AZJ4"/>
    <dbReference type="GeneID" id="2870958"/>
    <dbReference type="KEGG" id="ani:ANIA_06286"/>
    <dbReference type="eggNOG" id="KOG2161">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005386_0_1_1"/>
    <dbReference type="InParanoid" id="Q5AZJ4"/>
    <dbReference type="OMA" id="ERTKYWK"/>
    <dbReference type="OrthoDB" id="14419at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004573">
        <property type="term" value="F:Glc3Man9GlcNAc2 oligosaccharide glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009311">
        <property type="term" value="P:oligosaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031335">
        <property type="entry name" value="Glyco_hydro_63_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004888">
        <property type="entry name" value="Glycoside_hydrolase_63"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054491">
        <property type="entry name" value="MGH1-like_GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10412:SF10">
        <property type="entry name" value="GLYCOSYL HYDROLASE FAMILY 63 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10412">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03200">
        <property type="entry name" value="Glyco_hydro_63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22422">
        <property type="entry name" value="MGH1-like_GH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="1" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="1" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mannosylglycerate hydrolase MGH1-like glycoside hydrolase" evidence="4">
        <location>
            <begin position="445"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 63 C-terminal" evidence="3">
        <location>
            <begin position="708"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="920"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="920"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="988"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="1019"/>
            <end position="1029"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU369107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBF69778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="1036" mass="120208" checksum="C87F77DB54D8E5DF" modified="2005-04-26" version="1">MVLIDKQSYTSREEQRLKEDRDRIRYWKKWGPYVAERQWATVREDYSANGDAWSYFTHDHARSRTYRWGEDGIAGVCDTHNLQNIAFAFWNGKDGFLKERLFGLSNPQGNHGESIKEAHFHLDNTPTHSYMKYLYKYPQNEFPYQDLVEENARRGKQDREYQILDTGAFDNNQYWDIFIETAKEDDDEDEIVFRVIAYNRGPEPAPLHIIPHVWFRNTWSWGYEGREKPSIEQAAPLAVRTSHEKLGQRYVCFAPSPATGDSQEDVVPQMLFTENETNNELLWGTQNNQPYVKDAFHRYIVNDEKGAVNPANKGTKFAAWYAFNEGEGVPPGECAVVRFRLSRKMEPFVNEEELDDVVEQRKTEADDFYYHISPLPMSDDLRNIQRQAFAGMMWTKQYYHFVWDQWANGDPGMIAPPPERKHVRNQQWKHLYMDDILSMPDSWEYPFFAAWDTAFHCIPLAMIDPDFAKRQLDVLTREWYMHPNGQLAAYEWNFGDVNPPVHAWATFRVFKIERKMYGRQDLDFLERVFQKLLLNFTWWVNRKDFDGKNVFEGGFLGLDNIGLFNRSEPLPTGGVLEQADSTGWMAFYCLSMLNIALELAKHRRIYEDNLEEKRVLYGTKKTGMPQEFYYDAISYGEPWTQQLPVRSLVGLIPLYAVSTLEPELINKFPSFKRRLEWFVENRQDVAERNLASMKSRGKGDRLLLSLVSKDRLEKILKRMLDETEFLSDHGIRSMSKYHEKHPYSMDVNGQTFRVSYVPGDSDSGLFGGNSNWRGPVWLCVNFLLIESLLRFYMFYGDSFKVECPTGSGDYMHLGQVAEEIQHRLQHLFARNDEGRRAVHAGSDLLNFDEHWKDYMWFHEFFDGDTGRGLGASHQCGWTGLIAKIIHDTGVNCRLPQTPRSPFAAATHYFDDIFTRSVRNSSRRSSSHRPFVRRSSTSRSIGNRSDFESAFATPAPQTPVEPALDEEGKDRHGSNGTPGQEFDEHVSNYVRSQLQRVRSQVSMGAYEDEFETQVDAANGNGNGQPHGNGNGNATNGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="113" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B023</accession>
    <accession>C8V2J7</accession>
    <name>Q5B023_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ANIA_06107</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF70170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_663711.1">
        <property type="nucleotide sequence ID" value="XM_658619.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B023"/>
    <dbReference type="GeneID" id="2870779"/>
    <dbReference type="KEGG" id="ani:ANIA_06107"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN6107"/>
    <dbReference type="eggNOG" id="KOG0475">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003181_2_0_1"/>
    <dbReference type="InParanoid" id="Q5B023"/>
    <dbReference type="OMA" id="TDWVHDT"/>
    <dbReference type="OrthoDB" id="44789at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005247">
        <property type="term" value="F:voltage-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006878">
        <property type="term" value="P:intracellular copper ion homeostasis"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="CDD" id="cd03684">
        <property type="entry name" value="ClC_3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3080.10:FF:000013">
        <property type="entry name" value="Voltage-gated chloride channel (ClcA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3080.10">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="ClC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711:SF3">
        <property type="entry name" value="CLC CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00762">
        <property type="entry name" value="CLCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0868">Chloride</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="192"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="376"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="427"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="463"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="501"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="543"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="47"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="87"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBF70170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="909" mass="99157" checksum="1AEBCFD85DF9D56F" modified="2005-04-26" version="1">MPRSIPSYFTSAPPAEEHHDPENVSPGPRLNPRTAPPSPSVMRRTYSHLSESHTAYQSLEPPLEAGETTSLLGKAKEGGSGRMEPQRSYTTFSASSGPESGFRYTLLGSSLRRSRHHSRANSVHQRFSRRASMDEVPVESTAASIKDAMTSSFMDDRLWYDQFTSTDWVHDSVADGVRLRELRRRKDIRGRLLALFDGAQGWILVALIGCIVAAIAYFVDITEEYVFGLKNGICTTGWLRSRETCCADEEECPAWRSWSEMMNHHGGGSVSVDFGIYVLWSVILAAISCLLTLLTKTVVPSSVSLTTLDENLGANGSRQATEADGSPASVSGSSPYPPLPLRPDMVYYSAAGSGVAEVKVINSGFVLHGYLGFKTLVIKTLALIFSVASGLSLGKEGPYVHIATCVGNIACRLFSKYNLNDGKRREVLSASAASGVAVAFGAPIGGVLFSLEEVSYYFPPKTLFRTFFCCIAAALSLKFFNPYGTGKIVLFEVRYLGDWEIFELAIFMFLGVLGGAAGALFIKASSIWAKSFRRIPVIKRWPLFEVGLVALVTGLISFWNPYTKLPVTELLFQLASPCEHSTSDGLCPHPEGIGEVIRALTIAFVIKSFLTIVTFGIKVPAGIYVPSMVVGGLMGRIVGHVTQYLALQYPNFFLFGSSCAAGTGMESCVTPGVYAMVAAGATMCGVTRLSVTLAVILFELTGSLDHVLPFSLAVLCAKWTADAIEPHSIYDFLTEMNSYPFLDNKLQTVSDAVLGDIVRPIRRSRLIDITETPLVPARELRSKLQHLLMAGELDSGLPILRDGVLIGLIPAPDLEYALDNLEDEDRTSCLMATDTSSVVSDTDDEDTLQVDFTKYIDPAPLALDIHSPIDLVYQCFVKLGLRYLCVLHDGQYAGLVHKKAFVKFMKEQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B0N6</accession>
    <accession>C8UZV7</accession>
    <name>Q5B0N6_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Pol II transcription elongation factor subunit Cdc73, putative (AFU_orthologue AFUA_2G11190)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ANIA_05894</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CDC73 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF70618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_663498.1">
        <property type="nucleotide sequence ID" value="XM_658406.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B0N6"/>
    <dbReference type="FunCoup" id="Q5B0N6">
        <property type="interactions" value="201"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5B0N6"/>
    <dbReference type="GeneID" id="2870707"/>
    <dbReference type="KEGG" id="ani:ANIA_05894"/>
    <dbReference type="eggNOG" id="KOG3786">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025849_2_0_1"/>
    <dbReference type="InParanoid" id="Q5B0N6"/>
    <dbReference type="OMA" id="FRPDYWN"/>
    <dbReference type="OrthoDB" id="2186602at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016593">
        <property type="term" value="C:Cdc73/Paf1 complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11990:FF:000003">
        <property type="entry name" value="Pol II transcription elongation factor subunit Cdc73"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11990">
        <property type="entry name" value="RNA polymerase II accessory factor, Cdc73 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007852">
        <property type="entry name" value="Cdc73/Parafibromin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031336">
        <property type="entry name" value="CDC73_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038103">
        <property type="entry name" value="CDC73_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12466">
        <property type="entry name" value="CDC73 DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12466:SF8">
        <property type="entry name" value="PARAFIBROMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05179">
        <property type="entry name" value="CDC73_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="Cell division control protein 73 C-terminal" evidence="6">
        <location>
            <begin position="313"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="183"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="272"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="193"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBF70618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="504" mass="54766" checksum="54AAE79B18C915ED" modified="2005-04-26" version="1">MELLVELSVTTHLRFPPPRTAAARDHLRAIRSANKPRQIMATDPSLQDPLLALRRAIAAGSLPTATTSSELSTENATDDLAKATHLYFQHPLPQSLALNSPTRFNSSSSDSPVDLRSIFFAYQKKDVAIPEYIASVQELNEALKKKERADGAPEEQAQNLTFVERLDLITWLEGASDDSEYIKPLEGAGGVPSSATQAQTSASAGTGAAGASTGPSAAPAAGAAGGRAGKVIDPRLQEIYNGERKMGDRNSVLRGIKQTDFSHVRKVAETFLGRNRSRAGQYPPGTKPGTKPHSMIPAPSAGLSQPRKGTSKTQDPIILLSPSASSLIRMSNVRSFLGDGVFVPPDHPTLAMPNSAASNILYIHRPLGISDPSSSSRALGSQGHHARKPTRFILVDSTANFKPDYWQRLVAVFTTGQTWQFKSYKWSSPPELFKHAPGIYVGWRGEDIPREVRGWGRGVRSFFVERWDEKGGVNGSGRWRDREVVEGIWTAIEEGMKLRGWGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="116" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B0Z6</accession>
    <accession>C8VFE4</accession>
    <name>Q5B0Z6_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Proteasome core component, beta 6 subunit (Eurofung)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ANIA_05784</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF81196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_663388.1">
        <property type="nucleotide sequence ID" value="XM_658296.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B0Z6"/>
    <dbReference type="FunCoup" id="Q5B0Z6">
        <property type="interactions" value="1027"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5B0Z6"/>
    <dbReference type="MEROPS" id="T01.A12"/>
    <dbReference type="GeneID" id="2872075"/>
    <dbReference type="KEGG" id="ani:ANIA_05784"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN5784"/>
    <dbReference type="eggNOG" id="KOG0179">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035750_1_0_1"/>
    <dbReference type="InParanoid" id="Q5B0Z6"/>
    <dbReference type="OMA" id="CSGCWCD"/>
    <dbReference type="OrthoDB" id="268479at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd03757">
        <property type="entry name" value="proteasome_beta_type_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000027">
        <property type="entry name" value="Proteasome subunit beta type-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF2">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA TYPE-1"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBF81196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="261" mass="28608" checksum="6A0A7D4BC3F5C863" modified="2005-04-26" version="1">MTSLFSQDPHINPIGYSFAQPTNAGNKEHSFYPYTDNGGSVLGITGKDFAVLAGDTRSTSGYNINSRYVPKVFKIGGEDETGKGAHILLSVVGFAADGLALKERLDAVVKMYKYQHGKPMSVRACAQRLSTILYQKRFFPYYVQAILAGLDEEGKGALYGYDPVGSYEREQCRSAGAASSLIMPFLDNQVNLKNQYIPGSGEGHALEARKPEPMSRETVEQLVRDAFTSAVERHIEVGDGLQMLVITADGIEEVYHPLKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B109</accession>
    <accession>C8VFG4</accession>
    <name>Q5B109_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_05771</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF81234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_663375.1">
        <property type="nucleotide sequence ID" value="XM_658283.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B109"/>
    <dbReference type="STRING" id="227321.Q5B109"/>
    <dbReference type="GeneID" id="2872063"/>
    <dbReference type="KEGG" id="ani:ANIA_05771"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN5771"/>
    <dbReference type="eggNOG" id="ENOG502SYCV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073109_2_0_1"/>
    <dbReference type="InParanoid" id="Q5B109"/>
    <dbReference type="OMA" id="MNIAKMF"/>
    <dbReference type="OrthoDB" id="5398396at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="99"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="50"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF81234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="158" mass="17431" checksum="A00481F6B2515E41" modified="2005-04-26" version="1">MGWFDGRSSVSTSGAYVRKRSDRSPSRRSTTGYSTHHSRHSAPSIFDFGSTRGRSSPSVFSSSSRRARPRSGFIHRVVRYIRRLFRDIVNYARRHPVKVFMLVVVPLITSGVLVKLFSMIGIHLPKHIFGGSSSRSGSGGGGMASNINGLMNIAKMLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B166</accession>
    <accession>C8VFM6</accession>
    <name>Q5B166_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Leucine Rich Repeat domain protein (AFU_orthologue AFUA_1G06762)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_05714</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF81348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_663318.1">
        <property type="nucleotide sequence ID" value="XM_658226.2"/>
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    <dbReference type="AlphaFoldDB" id="Q5B166"/>
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    <dbReference type="KEGG" id="ani:ANIA_05714"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN5714"/>
    <dbReference type="eggNOG" id="ENOG502S6PB">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_016204_0_0_1"/>
    <dbReference type="InParanoid" id="Q5B166"/>
    <dbReference type="OMA" id="PSHIPHM"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
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        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
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    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="20"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="425"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF81348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="807" mass="89220" checksum="89726AF07734EE92" modified="2005-04-26" version="1">METVPPSYETATTRDAWTIIAQYIPSSDLCAATLVCRRWHAVFMPFLWGNPASHFGTENDEVYVALTRFRRTLRYARPEVRRLTHTLHMPPALSEIYGGPRPEWLREIFEYLPCLQSLIVSELPFFDHSAMMALRGAVSGGVSSRTYNTRLLIAEREPNTTSLGIAETLLRFPELIYLDLSYTTSAKDQTVLSALSQLERLQVLKLRGIGLKDIDAAFLANAIGHRVRFLDLRENKLTDTALQPLLHACFGPPNHDHLRPQSTFLRSPGLDEKFRKALTSPLTGRSWVEDLPNVGITHLYLADNQFSVNGIASILATSQLHVLDVGTLDMAKRSIKVQSNGRREAYAGSEKLIPILGTAAKENLTYLRAHHTICTSTALQERSMSGVDFLPELSGKHAMARASELDTHDTQIHELPADNTPVFEVAGSTPRPQSSDSVRSNKDGQSGIGYEHERPMAPRRGSAFAPEVLPSPNEAIRTTLAGFSDTHATISSAPIPLCSSPSLMEGPRARKIQELLAKRPNYQPRRQGIGSYFDFLHPSHIPHLEVLVLTDVPSHVSATSPILESLIRFVTACSNEALLATLQAGSDYSLPPGQDRARAEQERAKSLFGLRQLVLEITPVTHSLQPIKSTAWKSVSAQIGHQRSVTGDWDLERLWSAASDDFSFFNETECGIPADGTTCTAETHNASSASVPSVPIVDLVSELAAFRRRKKLEYEQVVRSTFQRRSMDDTLLPQSQSQYTMGSAAGASPSSSVRALSPVPGPYSFIAHHVEGHWKGEVKIVRNATPKGRSGWVDLYGNYFEKGYLYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B195</accession>
    <accession>C8VFQ8</accession>
    <name>Q5B195_EMENI</name>
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        <submittedName>
            <fullName evidence="6">Protein required for cell viability Rrp17, putative (AFU_orthologue AFUA_7G04220)</fullName>
        </submittedName>
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        <name evidence="6" type="ORF">ANIA_05685</name>
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        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
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    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
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            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRP17 family.</text>
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        <property type="protein sequence ID" value="CBF81407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="XP_663289.1">
        <property type="nucleotide sequence ID" value="XM_658197.1"/>
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    <dbReference type="AlphaFoldDB" id="Q5B195"/>
    <dbReference type="FunCoup" id="Q5B195">
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    <dbReference type="STRING" id="227321.Q5B195"/>
    <dbReference type="GeneID" id="2871976"/>
    <dbReference type="KEGG" id="ani:ANIA_05685"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN5685"/>
    <dbReference type="eggNOG" id="KOG4709">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067149_1_1_1"/>
    <dbReference type="InParanoid" id="Q5B195"/>
    <dbReference type="OMA" id="EWDGFPD"/>
    <dbReference type="OrthoDB" id="551633at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
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    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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    <dbReference type="InterPro" id="IPR019186">
        <property type="entry name" value="Nucleolar_protein_12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14577">
        <property type="entry name" value="NUCLEOLAR PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14577:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09805">
        <property type="entry name" value="Nop25"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="37"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="46"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="105"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="173"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="193"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="211"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBF81407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="221" mass="26265" checksum="64E97B30EC469F2C" modified="2005-04-26" version="1">MGPQIKGAHSRKRKLTSRVEEINFDDTDRHQFLTGFRKRKQQRIKHAQEVAERKVREAKREERKRMREERKAEFERALAEHKRQLKRLNEENESGDEAGNTSSGNEEEDEWDGFEEPPTVDYEAEYIDEDKYTTVTVEEMDPSKEGLLQSDEDSSDESPKERPDTSEGATPTEKPKAKKQPDNKLKKKKKKFRYETKDERKVTRMKERMANHRKAKARRER</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B1D2</accession>
    <accession>C8VFU8</accession>
    <name>Q5B1D2_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Formin GTPase-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_05648</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF81481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_663252.1">
        <property type="nucleotide sequence ID" value="XM_658160.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B1D2"/>
    <dbReference type="GeneID" id="2871938"/>
    <dbReference type="KEGG" id="ani:ANIA_05648"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN5648"/>
    <dbReference type="eggNOG" id="ENOG502RXE8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008022_0_0_1"/>
    <dbReference type="InParanoid" id="Q5B1D2"/>
    <dbReference type="OMA" id="WERCMGG"/>
    <dbReference type="OrthoDB" id="2155261at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010473">
        <property type="entry name" value="GTPase-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06371">
        <property type="entry name" value="Drf_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01140">
        <property type="entry name" value="Drf_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Formin GTPase-binding" evidence="2">
        <location>
            <begin position="11"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="783"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="394"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="414"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="792"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="833"/>
            <end position="842"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF81481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="842" mass="93535" checksum="1D1BC2AEA32DD700" modified="2005-04-26" version="1">MASTQAPAIFEDAPRSPTKPSVLRALLGHRRNQSADDAARSMPYTSGSSSSSSPVEQQYPPSNQQPLGEITPNGTPDGMFYPGSPNKSGKGLHKKTKSAVSLKSLKNYIERKPEKTADDPSSKPKKAKSTNSFTAILKRSQHGRKSDEVKDGRDKENRSPSDPADNIPSPVWTQYGTPTHSFRDESSPANSNRRRTLQEEVSLYTPKGYGPAQQRNFYDYHQPSLSSRTNVKPRPKSDFFANGSKVKDLLGPFQGLSPSKQSLVDQQEPTSKMECGRPRGLSTPDARSETESRQASPKKPSRVQEVISAFNAKEREADLQKRLNAKDLESEFEKLLVSIPTQIGWRELTWTGCEEHSSQHEGQDEKDKLESTTPHSAASTYAAESTGRRGRGKDKKEEHDSHDSKGSRSRSRSRGFTFSRGNSSSPTKKRPESGSSHRRPKSIDLSAPGLSKILTPNASTTSLAVTAHRDTATDPSDFVHYLKEIQKPEIIEVGKIHKLRILLRNETVSWVDSFIAEGGMDEIVQLVYRIMKVEWREEHEDNLLHETLLCLKALCTTSVALQRLTDIEAELFPALLGMLFDKEKKGPSEFTTRGIIINLIFTQLSTAASAEDGAARTNRILSYLRDPPEENQPLSFIANIYQSRPYRVWCKEISNVTKEVFWIFLHHLNVIPVVQSDKSLESYRERHFPAPRPPVPAAPYVGGVEWDATNYLAAHIDLINGLIASLPTVEERNNLRKELRASGFEKVMGATLRTCKEKFYSSVHDCLRTWVSAAVEDGWPHLAVREGPPRQEASSPTRSPVKSPNKKGGLNDLPPKLDLKIDIPVGGGGGGNRKGDPIGDWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B1I6</accession>
    <accession>C8VG11</accession>
    <name>Q5B1I6_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_05594</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
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            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
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            <dbReference type="EMBL" id="CBF81597.1"/>
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    </evidence>
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    <accession>Q5B2K7</accession>
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        <name evidence="3" type="ORF">ANIA_05223</name>
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    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
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            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CBF81114.1"/>
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</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="79" xmlns="https://uniprot.org/uniprot">
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        <name evidence="2" type="ORF">ANIA_04747</name>
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        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
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            <taxon>Eurotiomycetes</taxon>
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            <taxon>Aspergillaceae</taxon>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
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                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
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            <dbReference type="DOI" id="10.1038/nature04341"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF76874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="XP_662351.1">
        <property type="nucleotide sequence ID" value="XM_657259.1"/>
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    <dbReference type="AlphaFoldDB" id="Q5B3Y3"/>
    <dbReference type="GeneID" id="2872545"/>
    <dbReference type="KEGG" id="ani:ANIA_04747"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN4747"/>
    <dbReference type="eggNOG" id="ENOG502QTWB">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_123459_0_0_1"/>
    <dbReference type="InParanoid" id="Q5B3Y3"/>
    <dbReference type="OMA" id="IARECWE"/>
    <dbReference type="OrthoDB" id="2139606at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
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    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
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        <property type="term" value="P:cellular response to oxidative stress"/>
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        <property type="term" value="P:protein N-linked glycosylation"/>
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        <property type="entry name" value="N-glycosylation_EOS1"/>
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        <property type="entry name" value="N-GLYCOSYLATION PROTEIN EOS1"/>
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        <property type="entry name" value="N-GLYCOSYLATION PROTEIN EOS1"/>
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        <property type="entry name" value="EOS1"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="74"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="113"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="138"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="CBF76874.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="211" mass="23702" checksum="E20AFB9B1A88BD59" modified="2005-04-26" version="1">MSTAPAAWWGLRCAFTFLAELLRIRPGMGHEGWAAAIVGSVSQNWDVERRFRVTEVALAIMWCCASAYLSYFFADCMMSRWLLNYTPPAVVIRLLTTNGLIAYMTSWVLYLSGASSDPRLLLPAWISITTTLTFLYHATQNHATIKRETAASLLVVSVASFVSMSSLLLQLHLTRENEPEVPLFVLTRKIWDFAVAVVQRMRVANDHVGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="128" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B4S0</accession>
    <accession>C8V8I1</accession>
    <name>Q5B4S0_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Small nucleolar ribonucleoprotein complex subunit, putative (AFU_orthologue AFUA_4G07540)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ANIA_04460</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the ASTRA complex involved in chromatin remodeling.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF77475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_662064.1">
        <property type="nucleotide sequence ID" value="XM_656972.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B4S0"/>
    <dbReference type="FunCoup" id="Q5B4S0">
        <property type="interactions" value="1021"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5B4S0"/>
    <dbReference type="GeneID" id="2872260"/>
    <dbReference type="KEGG" id="ani:ANIA_04460"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN4460"/>
    <dbReference type="eggNOG" id="KOG0319">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009276_0_0_1"/>
    <dbReference type="InParanoid" id="Q5B4S0"/>
    <dbReference type="OMA" id="PYVQRHF"/>
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        <property type="component" value="Chromosome III"/>
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        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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        <property type="term" value="C:nucleolus"/>
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        <property type="project" value="GO_Central"/>
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    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
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        <property type="project" value="GO_Central"/>
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        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Small nucleolar ribonucleoprotein complex subunit, putative"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="2.130.10.10:FF:001238">
        <property type="entry name" value="Small nucleolar ribonucleoprotein complex subunit, putative"/>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
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        <property type="entry name" value="Utp13_C"/>
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        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
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        <property type="entry name" value="WD40_PAC1"/>
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        <property type="entry name" value="WD40_repeat_CS"/>
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        <property type="entry name" value="WD40_rpt"/>
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        <property type="entry name" value="TRANSDUCIN BETA-LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19854:SF15">
        <property type="entry name" value="TRANSDUCIN BETA-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08625">
        <property type="entry name" value="Utp13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="13"/>
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    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
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        <location>
            <begin position="107"/>
            <end position="148"/>
        </location>
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    <feature type="repeat" description="WD" evidence="6">
        <location>
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    <feature type="repeat" description="WD" evidence="6">
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    <feature type="repeat" description="WD" evidence="6">
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    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="543"/>
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        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="617"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 13 C-terminal" evidence="8">
        <location>
            <begin position="777"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
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            <begin position="168"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
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    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="719"/>
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    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="174"/>
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    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="187"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="721"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBF77475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="977" mass="105245" checksum="7A4A84BD53D946A3" modified="2005-04-26" version="1">MSKAVVKTTFEASRTLRPIYTGGSTALDASGRLLVACVNEDALVVDLETGNQLATLDGDGEVITSLAITPSASHVILCSRSMSMRIYSLSQYEDTTPTLETKLVRSLKPHTAPVVTTATDSTGTLLATGAADGSIKVWDIRGGYITHSFHGHGGVISALCFFQPPTAEHDGKLSSKKKPKRKTGMAGDDDDNEMMDLDSASNSNGAFRLASGSEEGKVRVWDLNKKKSIASLDSHVSVVRSLSYSLTENALLSAGRDKTVIVWDMRTFKTRRIIPVLESAEAASFVAEGGLCLVGGEYGRLRVWDCNRGGEVTGDQEAAPEFEAIIAIHYTPGMSFAMTVHADQTLRLHSLEPLSNLKPGTTIDPLPVVRRISGNDDDIIDLAYVGPDRSMLALATNTESIRIVSVGPSDYRPSTDGQEYFGADIAHLDGHDDIIICIDVDWSGHWLATGAKDNTARLWRLDPQNSSYTCFALLTGHAESLGAISFPRDSPPPDTPAYKAPVNHPPPFVITGSQDRTVKRWNVGKLGPTIGNKPHTPKALFTRKAHDKDINALDVSPSSALFASASQDRTVKIWSADDGSVVGVLRGHKRGVWSARFSPKGTPILSADAKSSTNRGMIVTGSGDKTVKLWSLSDYSCLLTFEGHTNSVLKVLWLPPPDMSSKTEDEEDEDAAASKPNSIQLRPLVASAAADGLVKIWSPYTGELETTLDNHTDRVWALASPTPSGTRDDVNSSATKSTSPYAIASGSADSTVTFWTDTTSATYTAAVNANSARIEQDQQLQNYIVAGAYREAITLALQLNHPARLLSLFSAAIDAADDPHNTDNQGEDRANSFTGNPSIDEVLQTLDPANLYVLVLRLRDWNTNARHSKVAQRILFALFRSYPASTFVELASSSIAKRNGDGRAAAAMKDILQALASYTERHYRRVEELEDESYLVEWVLGEMDGGIGLSALGAPTQGINEIEDKAEHGKDVVMLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B4V7</accession>
    <accession>C8V8R6</accession>
    <name>Q5B4V7_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_04423</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF77553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_662027.1">
        <property type="nucleotide sequence ID" value="XM_656935.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B4V7"/>
    <dbReference type="STRING" id="227321.Q5B4V7"/>
    <dbReference type="GeneID" id="2872223"/>
    <dbReference type="KEGG" id="ani:ANIA_04423"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN4423"/>
    <dbReference type="eggNOG" id="ENOG502SD2Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074375_0_0_1"/>
    <dbReference type="InParanoid" id="Q5B4V7"/>
    <dbReference type="OMA" id="VYMPSMA"/>
    <dbReference type="OrthoDB" id="3993201at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAP" evidence="1">
        <location>
            <begin position="49"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF77553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="250" mass="27364" checksum="BE914D5E1FA57B2A" modified="2005-04-26" version="1">MAAPRSTSLRALRLLSQQHTFSPAYRRGLHITGAHSAQPANVSDKATLYSTRSLADLKSECQKRSLRATGTHAELVERLSNHDFLQSRAFSIAMRRINSSSKPDTPSRTFNTSRSLKAVNDSSTVDFAYMPSIDESNNSSWDAPVPILPETYTHHEPAAPSSAPMKPQVYTVSGDGIDVSASPMSEVVDNDSMEIDPFSLTEAVGKSRYAAQLKSQQEQSGAKSIASELWNGLLDDLLGPKQQRQSPMRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B6C3</accession>
    <accession>C8V698</accession>
    <name>Q5B6C3_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcription factor TFIID complex 145 kDa subunit, putative (AFU_orthologue AFUA_6G08600)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ANIA_03907</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF75121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_661511.1">
        <property type="nucleotide sequence ID" value="XM_656419.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B6C3"/>
    <dbReference type="FunCoup" id="Q5B6C3">
        <property type="interactions" value="385"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5B6C3"/>
    <dbReference type="GeneID" id="2873329"/>
    <dbReference type="KEGG" id="ani:ANIA_03907"/>
    <dbReference type="eggNOG" id="KOG0008">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000572_1_1_1"/>
    <dbReference type="InParanoid" id="Q5B6C3"/>
    <dbReference type="OMA" id="RFINYYR"/>
    <dbReference type="OrthoDB" id="5752at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040240">
        <property type="entry name" value="TAF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022591">
        <property type="entry name" value="TAF1_HAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13900">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13900:SF0">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12157">
        <property type="entry name" value="DUF3591"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription initiation factor TFIID subunit 1 histone acetyltransferase" evidence="4">
        <location>
            <begin position="445"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="290"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="410"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="772"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="891"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1007"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="39"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="52"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="110"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="292"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="782"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="899"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="935"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1007"/>
            <end position="1017"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBF75121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="1092" mass="122567" checksum="C235AC5AA4C9B94E" modified="2005-04-26" version="1">MPHATATSPGPEVEDADFDNVMRQMNGPMTDGGMSFDFLSRELEPGEKADDAVDYEDFDDDELPEEEEITQHNARAVAENGLEAPETSDDALFGGGGDDLFEAPGKDEQAAPDELDDLFGEAPSSPRPDLADETRDLFFEEEERPTAVQRPQAIQMDEDQELLQDDEPLSPVADDMDPASLRAWKLQQALFAMSNVGPDNPPAPPENVEELLQSLFPMFERNTLPRFLELIPHKKAYFVGKTPLKPPKPVLPGKVNIELAQDQEKVFRSGGQTFKRSLEAEHHGIVPVAETSQEEEEEEARDEFDLDYESDEPLPGGITADDLRVVCADWDVRDDIPTMDIDEPAIVESAEDDWLFETTRPAKKRKLGRDPMEIVSLSHIDLPLLDDPEQASSKVAQKVTLDLNDPYMLLDERGPDTAASKPRASGVRSRDEMDANVTRRLTARYNISNDQAYDMLKQNHQNKVRSTLGNVTLEHSMPALRLQWPYYKTELAKAEARSFHRPALSFRPGQSCWFKNPAYIKRKHQKGKDIRQLYDSTKSLSMADNSHVLLVEYSEESPLTLSNFGMANRIINYYRKKNAEDPTRPKAEIGETAVLLPQDKSPFSIFGHVDPGEVTPAISNAMYRAPLFSHQPKSTDFLVIRNSTGSGGSDYYIRNIDNIFVAGQQFPSVDIPGPHSRKVTTVAKNRMKMLVYRLLKKSPDLRLSISDVTAHIPGTSDMQNRQKVKDFLQHDKDTKYWVPLEPVPEQDVIRSWVQPEDVCLLEAMQVGQQHLHDTGYGNDAETGGDDDNDEESESFEQQMAPWKASRNFLLASQGKAMLKLHGEGDPTGRGEGFSFIKTSMKGGFKAIGESVEDKLDAQRLKELGGHSYNVARQQKSYETSIRRIWDAQKASLSSTIEHSDDEVNMSEEEEDDFNKPTPRSEAPTPAPARRDDETTSQFSKMSRMSMSAHKGKVLRIVRQVQDKDGVRQKETLVSDPRVIRHYLQHRHRVESLTTNLEQELSRLNRNKERRFAREKQKGVLRNSADSPADGAPGSSKAGGTQRKCANCGQVGHIKTNKKCVYNRSRSAGAADGYPDSFDITQSFFVNPSTTFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B6W8</accession>
    <accession>C8V7J4</accession>
    <name>Q5B6W8_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dienelactone hydrolase family protein (AFU_orthologue AFUA_6G12740)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_03712</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF75555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_661316.1">
        <property type="nucleotide sequence ID" value="XM_656224.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B6W8"/>
    <dbReference type="FunCoup" id="Q5B6W8">
        <property type="interactions" value="248"/>
    </dbReference>
    <dbReference type="ESTHER" id="emeni-q5b6w8">
        <property type="family name" value="Dienelactone_hydrolase"/>
    </dbReference>
    <dbReference type="GeneID" id="2873136"/>
    <dbReference type="KEGG" id="ani:ANIA_03712"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN3712"/>
    <dbReference type="eggNOG" id="KOG3043">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054590_2_1_1"/>
    <dbReference type="InParanoid" id="Q5B6W8"/>
    <dbReference type="OMA" id="PKQKWAK"/>
    <dbReference type="OrthoDB" id="17560at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000791">
        <property type="entry name" value="Dienelactone hydrolase family protein (AFU_orthologue AFUA_6G12740)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630">
        <property type="entry name" value="DIENELACTONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630:SF44">
        <property type="entry name" value="PROTEIN AIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dienelactone hydrolase" evidence="1">
        <location>
            <begin position="31"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF75555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="245" mass="27040" checksum="B67878A5F56A30EB" modified="2005-04-26" version="1">MASNPPGACCASGFRHEGNPVGEIKNVNGTDTYIVYPKDNKSPEKAIIILSDIFGIYVNAQLLADEFAENGYLAVLPDLFRGDAIKLSDMESGRANLPEWLPKHQTPVVDPIVEATIKYVRGDLGVKRVAGVGYCFGGKYVCRFLKPGKLDVGYTAHPSFVTEEELAAIAGPLSICASEIDQIFTTELRHKSEEILIKTGQNWQINLYSGVTHGFAVRADLSNKHHKFAKEQTFCQAVNWFNQYL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-06-12" modified="2025-06-18" version="126" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B778</accession>
    <accession>C8V477</accession>
    <name>CCR4_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CCR4-Not complex 3'-5'-exoribonuclease subunit Ccr4</fullName>
            <ecNumber>3.1.13.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Carbon catabolite repressor protein 4</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Cytoplasmic deadenylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Glucose-repressible alcohol dehydrogenase transcriptional effector</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">ccr4</name>
        <name type="ORF">AN3602</name>
    </gene>
    <organism>
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Acts as a catalytic component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover (By similarity). Ccr4 has 3'-5' RNase activity with a strong preference for polyadenylated substrates and also low exonuclease activity towards single-stranded DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>Exonucleolytic cleavage of poly(A) to 5'-AMP.</text>
            <dbReference type="EC" id="3.1.13.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the CCR4/nocturin family.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.4"/>
    <dbReference type="EMBL" id="AACD01000061">
        <property type="protein sequence ID" value="EAA59810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF75800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_661206.1">
        <property type="nucleotide sequence ID" value="XM_656114.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B778"/>
    <dbReference type="SMR" id="Q5B778"/>
    <dbReference type="FunCoup" id="Q5B778">
        <property type="interactions" value="441"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5B778"/>
    <dbReference type="EnsemblFungi" id="CBF75800">
        <property type="protein sequence ID" value="CBF75800"/>
        <property type="gene ID" value="ANIA_03602"/>
    </dbReference>
    <dbReference type="KEGG" id="ani:ANIA_03602"/>
    <dbReference type="eggNOG" id="KOG0620">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016428_4_0_1"/>
    <dbReference type="InParanoid" id="Q5B778"/>
    <dbReference type="OMA" id="PHYYARA"/>
    <dbReference type="OrthoDB" id="428734at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004535">
        <property type="term" value="F:poly(A)-specific ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd09097">
        <property type="entry name" value="Deadenylase_CCR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.10.10:FF:000037">
        <property type="entry name" value="Glucose-repressible alcohol dehydrogenase transcriptional effector"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000447">
        <property type="entry name" value="Glucose-repressible alcohol dehydrogenase transcriptional effector"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050410">
        <property type="entry name" value="CCR4/nocturin_mRNA_transcr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025875">
        <property type="entry name" value="Leu-rich_rpt_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121">
        <property type="entry name" value="CARBON CATABOLITE REPRESSOR PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121:SF100">
        <property type="entry name" value="POLY(A)-SPECIFIC RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12799">
        <property type="entry name" value="LRR_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0269">Exonuclease</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0433">Leucine-rich repeat</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0540">Nuclease</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_0000290612" description="CCR4-Not complex 3'-5'-exoribonuclease subunit Ccr4">
        <location>
            <begin position="1"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="repeat" description="LRR 1">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="repeat" description="LRR 2">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="repeat" description="LRR 3">
        <location>
            <begin position="226"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="repeat" description="LRR 4">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="30"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="33"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="58"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="360"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="O95551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="3">
        <source>
            <dbReference type="UniProtKB" id="P31384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <sequence length="675" mass="76463" checksum="429D543290F01AAA" modified="2005-04-26" version="1">MYSQTHQQQHVIMNGGQAHQRFGMQMKFQTQNHHPHPAQQPHHHAHHNQPPQHVGHQHNFSSGALASATPHFTPSHIQNGTHTNIDEELDESMNEHWQQQLQLAAESRQASSPHYYARAVAQQTKGIQIAPSQPEAQENGVNQKNGITKTKPASRQGWHALDFGGQGLRALAPSLFKYAFLEKLYLSHNKLKVLPPQIGQLRKLTHLDLSANDLTELPEEIGMLTNLRHLLLFDNNIRTLPYEMGYLYRLEILGIEGNPLEDVLKSLIMKEGTKALIRYLKEEMPVHVPPPARDWLVLDETAATSPDKVSVLSYNTLCDSSATQSHYGYAPSRVLSWEFRRETILNELRAHDPDIICLQEIDQGSYNEFFREQLAYSDYKGVFWPRGRAMGMQEEDAKGVDGCATFFKGSKFILLDKQVINFGQTAVRRPDAKGQDDIYNRLWQKDHIAVIVFLENRQTGSRFIIVNAHLYWDPAFKDVKLIQTAILMEEITKHSEKYAKWPPCTDKAAFRFREAQGEQTMPEPAPSAEYASGDQIPLFMCGDFNSSPGSAAYNLIANGGLIEEHPDLEKRMYGNLSKVGMTHPFKLKSAYGAIGELSFTNYTPDFKDILDYIWYSSNTVHVSGLLGEVDKDYLQRVPGFPNYHFPSDHIALLAEFSVKGKKGKVVEADFGPQRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B7B2</accession>
    <accession>C8V4G3</accession>
    <name>Q5B7B2_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_03568</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
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<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="109" xmlns="https://uniprot.org/uniprot">
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        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
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        <dbReference type="NCBI Taxonomy" id="227321"/>
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            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
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        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
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            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
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    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
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        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
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        </source>
    </evidence>
    <sequence length="1622" mass="176081" checksum="E40022D7A86B1ECD" modified="2005-04-26" version="1">MADPLSIASGVAGLLSLGIQRIKDQESDLIQITQNLGNLLVIFTALDEALLRRRPRIDDQELVGSIDRSIWGCKEIIKELEAECHKLQETSTAGFKGQIKSAGRRVAYPFRKSTLQKLEEDISEIRENLSLALDVLQLKSNNTLQEDLSKLRSLLEHINATHISSEIRSWLMAPDATSDHNAACEKHHSGTGTWFIEGHHYKNWLMERNSLIWINGFAGCGKSVMCSTAIQSTFLESQYRHNVGIGFFYFSFRDKSKITASGMLRALLLQLSAQLNDGEKDLQQLHATYRLGTPPVEALLNSLQNTFSKFQDTYILLDALDESPRESEREGVLKAIEIMRQWRLPGFHLLVTSRDELDIRQSLKPAHHQDLMMRNSEAEKDIANFVSYQLSHDPKFQRWKSRHREIEDNLAKKSQGVFRYVECQLIALKRARNQNRLDECLRSLPRDLDETYERILCSIDKDDAGDVQRILTVLCVSKRPLSVHELIDAHAIDLAEPPHLDRDGRSYDPDDLIDICRGLIEFSVIEQDNEKKTTVARIAHFSVQEYLESDRVQKEAKAFAIHKERANIELAQICLVYLLEPKLCDSPLDETRLAEFPLAQFAAMHWYSHYRDGSGMESAAEDLILRLFNNNAKSFLTWLQLHDLDSMRDWDLTLRKDLEDIPSPLYYAALLGLESTLNTLITTSANKSSHEDFVNVKGGRYGNALQAASYAGHDKIVQILLDHGAEVNARGGWYGNALYAASAHGHKEIVQILLDHGAGVNARSRGYKNALYAASANGNKEIVQILLDHGAEVNTQGGYYANALYAASYKGHEEIVQILLDHGAEVNTQGGHWGNALQAASARGHEEIVQILLDHGSEVNAQGGEYANALQAASNTGNEKIVQILLDHGAEVNAQGGDYGNALQAAAAIDHEEIVQILLDHGAEVNAQGGWYGNALQAASYTGYKRIVQILLDYGAEVNAQGGCYGNALQAASARGHEKIVQILLDHGAEVNTQGGCYGNSLQAALYAGYDKIVQILLDHGAEVNARGGYYGNVLYIASAKGHEEIVQILLDHGAEVNAQGREYENPLQAASAEGHEKIVQILLDRGAEVSAQGGEYGNALYAASNAGFEKIVQILLDHGAEVNAQGGEYGNPLQAASAEGHEKIVQILLDHGAEVNAQGGEYGSALQAASARGYEKIVQILLDRGAEVSAQGGEYGNALYAASNAGFEKIVQILLDHGAEVNAQGGEYGNPLQAASAEGHEKIVQILLDHGSEVSAQGGCYGNALQAASYAGYEKIVQILLDHGAEVSAQGGHYGNALQAASARGYEEIVQILLDHGAEVNAQGAEYGNALQAASYKGNRKIVQILLDYGAEVNTQGGYYASALQAASADGDEKIVQILLDHGAEVNIQGGEYGNSLQAASYQGYEKIVQILLDHGAEVNAQGGEYGNPLQAASAEGHEKIVQILLDHGAEVNAQGGHYGNALQAASCAGNEKIVQILLDHGAEVNARGGLYGNALYAASDRGRDKIVQILLDHGAEVNAQGGDYANALQAASYAGNEEIVRILLDRGAEVNAQGGEYGSALQAASAEGHEKIVQILLDHGAEVNAQGGEYGSALQAASAEGHEKIVQILLDQGAESNPHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B7R8</accession>
    <accession>C8VHK8</accession>
    <name>Q5B7R8_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Integral membrane protein, Mpv17/PMP22 family, putative (AFU_orthologue AFUA_7G01470)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ANIA_03412</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peroxisomal membrane protein PXMP2/4 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF82760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_661016.1">
        <property type="nucleotide sequence ID" value="XM_655924.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B7R8"/>
    <dbReference type="FunCoup" id="Q5B7R8">
        <property type="interactions" value="565"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5B7R8"/>
    <dbReference type="GeneID" id="2874306"/>
    <dbReference type="KEGG" id="ani:ANIA_03412"/>
    <dbReference type="eggNOG" id="KOG1944">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049109_8_1_1"/>
    <dbReference type="InParanoid" id="Q5B7R8"/>
    <dbReference type="OMA" id="WYQSKLA"/>
    <dbReference type="OrthoDB" id="430207at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006067">
        <property type="term" value="P:ethanol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007248">
        <property type="entry name" value="Mpv17_PMP22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2, PXMP2 MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266:SF17">
        <property type="entry name" value="PROTEIN MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04117">
        <property type="entry name" value="Mpv17_PMP22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBF82760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="202" mass="22028" checksum="402E6A69ECC94F3A" modified="2005-04-26" version="1">MLRWYQAKLAKQPILTASVTSALTPCPFKVLFGAGDALAQQAVERRGLEKHDFARTGRMTFYGGANADQAVFGPVATLWFRFLQRNIALNNPKATIIARVAADQCLFAPAHLTFFLSSMAIMEGTDPVAKWKQSFVPGYKANLAVWPLVQGINFAFVPLELRVLVVNVISLGTYRSSPSHPTLLTCPSGWNCVLSVINSGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="102" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B830</accession>
    <accession>C8VI01</accession>
    <name>Q5B830_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Zn(II)2Cys6 transcription factor (Eurofung)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ANIA_03300</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF83002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_660904.1">
        <property type="nucleotide sequence ID" value="XM_655812.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B830"/>
    <dbReference type="STRING" id="227321.Q5B830"/>
    <dbReference type="GeneID" id="2873763"/>
    <dbReference type="KEGG" id="ani:ANIA_03300"/>
    <dbReference type="eggNOG" id="ENOG502SH4R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020030_0_0_1"/>
    <dbReference type="InParanoid" id="Q5B830"/>
    <dbReference type="OMA" id="DRWNVHL"/>
    <dbReference type="OrthoDB" id="5130013at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF8">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="128"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBF83002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="622" mass="69972" checksum="F4B01AD74B2A77F2" modified="2005-04-26" version="1">MVSLDERHSRFPLKPVVFRRHGSPRKSHHPHRLDLATLTGLSWPLWSEIRDLLGAVRIVDRPDPALPEVPKPYWFIRKAVVVFKSFPQLGIIFLGGSYMTPQSGGAMLHASMFLYIGGPLGTVVAQEACYTCRRRHIQCDRSQTPCRKCEKAGLKCLDKRPIRWVQGVAIRGGMRGRSHQNEIISSTPVSAIEMALEPSIKIQEPLDARASTQIVPKDTPISMPVSMEDEPLAKLDPSARYYLNYYNDRICQVFIVYDSKNNPFRSLISLALSDSVLLDAMLALAARHRANSEQPFSANRADVSTVSTDADREALQFKYRAIQGLSRTVSSQHSYRVATVATVFLLVFLDLLESGCDRWNYHLEGAKTLMTLTPSSDPGRTIERIRKFIVKQIHLIESLGATFVRPELLSKCPSIDESSNLLDDVIEESFLGCPEFILTAVQFFSLQRDTIANENSPGQPRAEDVLSILDAVRNFDCRAWASALPQESVTHDLDGLTKLARAYQLGGILYGQRILDAVEKTRTSRETVLSELIDIITSLQPTNLLKCTLWPITIAGLECQARRQRDLLIQALKKFWQDTKCSNVTSAADILQNYWSKTDHNPDVANDWIFDIGRSSHDWLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B8I7</accession>
    <accession>C8VIH3</accession>
    <name>Q5B8I7_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">DUF1212 domain membrane protein Prm10, putative (AFU_orthologue AFUA_3G13940)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ANIA_03143</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ThrE exporter (TC 2.A.79) family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF83321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_660747.1">
        <property type="nucleotide sequence ID" value="XM_655655.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B8I7"/>
    <dbReference type="GeneID" id="2874140"/>
    <dbReference type="KEGG" id="ani:ANIA_03143"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN3143"/>
    <dbReference type="eggNOG" id="ENOG502QPMM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007078_2_2_1"/>
    <dbReference type="InParanoid" id="Q5B8I7"/>
    <dbReference type="OMA" id="KKRVGWH"/>
    <dbReference type="OrthoDB" id="413008at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010619">
        <property type="entry name" value="ThrE-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051361">
        <property type="entry name" value="ThrE/Ser_Exporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024528">
        <property type="entry name" value="ThrE_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31082">
        <property type="entry name" value="PHEROMONE-REGULATED MEMBRANE PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31082:SF4">
        <property type="entry name" value="PHEROMONE-REGULATED MEMBRANE PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06738">
        <property type="entry name" value="ThrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12821">
        <property type="entry name" value="ThrE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="520"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="546"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="596"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="641"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="681"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="706"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="730"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="756"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="834"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="domain" description="Threonine/serine exporter-like N-terminal" evidence="8">
        <location>
            <begin position="414"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="domain" description="Threonine/Serine exporter ThrE" evidence="9">
        <location>
            <begin position="687"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="260"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="309"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="174"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="350"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF06738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBF83321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="869" mass="94229" checksum="35B88E11FCC8D668" modified="2005-04-26" version="1">MAGGYFDLPTTSSQRSSLTDVPEADARGPSPPGPRVSPSEGSNEALPERATLDPGGAHGKQRNAGILKSANRVKFTVGEAALPPTSQRRGSPLPQRPLPTASIPAYERTASDPHPFPNGEPSSTFPAGTAVYSRDSSSGIVATDEVSNEKGRAIHSAYSAQERAQKLASHLGRPSKSPSQSPWPSLPSSVASSPTEASQPFEDADDIPMIRLPEKQLDYPSDEDDDYYGLVDGRPHNRNSEAHQLVEQMTRRDFHLLNRISANSPSGLRSGPVTPIEERDPDAYVQRPTHYRGGILSSLLKLYEQPTLNLPRGRYGHSRQSSSGDLSARGLSPDPSWRAPQKPRKWYEKSANQSNTSLSGSTAKNSISSPFSMLRRSRSSGAIPGMSKRMGKPQLEDEIRITVHIAELLARQRYLLILCKALMKFGAPTHRLEEYMKMTARVLEINANFLYLPGCMIVSFDDASTHTTEVKLVRVNQGVDLGKLSDAHTVYKEVIHDVIGVEEAMQRLSKLLQKDNKYPIWLLILFHGLASASVGPFAFGARPIDMPIAFVLGCLLGILQLVLSPRSHLYSNVFEISAAVLTSFLARAFGSIPYKGGHLFCFAALAQSSIALILPGYLVLCASLELQSRSIVAGSVRMVYAIIYSLFLGFGITIGTAVYGLLDRHASTDYTCPASPITNEYLQRFPFVIIFTFCLATVNQAKWKQIPVMLVIAFAGYITNYFGAKRFYSSTQVSSALGAFVVGVMANLYSRLRHGLAAAAMLPAIFVLVPSGLAASGSLVAGIASAGQITTQQTPFSVPSNGTQSFVDAAKNMTAEHRQQSYQENPFQGVVFDIGYGMVQVAIGFTVGLFLAALVVYPLGKKRSGLFSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="118" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B9D2</accession>
    <accession>C8VJD7</accession>
    <name>Q5B9D2_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Spliceosomal protein DIB1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ANIA_02848</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Essential role in pre-mRNA splicing. Also essential for entry into mitosis (G2/M progression) as well as for chromosome segregation during mitosis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the DIM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF83881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_660452.1">
        <property type="nucleotide sequence ID" value="XM_655360.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B9D2"/>
    <dbReference type="FunCoup" id="Q5B9D2">
        <property type="interactions" value="876"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5B9D2"/>
    <dbReference type="GeneID" id="2873913"/>
    <dbReference type="KEGG" id="ani:ANIA_02848"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN2848"/>
    <dbReference type="eggNOG" id="KOG3414">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_117348_0_0_1"/>
    <dbReference type="InParanoid" id="Q5B9D2"/>
    <dbReference type="OMA" id="GMYELYD"/>
    <dbReference type="OrthoDB" id="147752at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02954">
        <property type="entry name" value="DIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000004">
        <property type="entry name" value="Spliceosomal protein DIB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004123">
        <property type="entry name" value="Dim1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12052:SF5">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEIN 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12052">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEN 4A, 4B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02966">
        <property type="entry name" value="DIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017199">
        <property type="entry name" value="mRNA_splic_U5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01410">
        <property type="entry name" value="DIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4 6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR017199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBF83881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="143" mass="16930" checksum="C46826A78352BFF2" modified="2005-04-26" version="1">MGSVVLPHLRTAWHVDQAILSEEDRLVVIRFGRDHDVDCMRQDEVLFKIAERVKNFAVIYLCDIDEVPEFNTMYELFDPMTIMFFFRNKHIMCDFGTGNNNKLNWVLEDKQELIDIIETIYKGARKGRGLVVSPKDYSTRYRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="99" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B9N4</accession>
    <accession>C8VJX9</accession>
    <name>Q5B9N4_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">MFS monocarboxylate transporter, putative (AFU_orthologue AFUA_1G05170)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ANIA_02746</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF84100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_660350.1">
        <property type="nucleotide sequence ID" value="XM_655258.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B9N4"/>
    <dbReference type="GeneID" id="2874471"/>
    <dbReference type="KEGG" id="ani:ANIA_02746"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN2746"/>
    <dbReference type="eggNOG" id="KOG2504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_1_1_1"/>
    <dbReference type="InParanoid" id="Q5B9N4"/>
    <dbReference type="OMA" id="TWGAYQT"/>
    <dbReference type="OrthoDB" id="6509908at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd17352">
        <property type="entry name" value="MFS_MCT_SLC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF280">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05170)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="246"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="283"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="312"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="338"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="375"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="402"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="5">
        <location>
            <begin position="247"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBF84100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="436" mass="47163" checksum="6FE1CC7A2C568689" modified="2005-04-26" version="1">MGANVDAQERTVSAMGGSQDVEKTSAAPVQPAEDKEEPTFDTGLACWLQVLGSWFLFFNSWGVVNTWGVYQTYYEQNQLSDISSSSIAWVGSLQSFLLMLFGVVTGPLFDAGYFRLLLGFGTIMLPFGFMMVSISSKFWHFILAQGVCVGLACGCLFVPAVAILPQYFRKRRGLANGIAATGSSIGGVIYPIMFNELQKKAGFHWATRAVGFLAFGTCLISFSLMRMRFLPTEKRKLIQLGAFKEPIFVLFSIGMFMGFLGFYNFLFYVQSYAIETGIVDGNLGFYLLAMLNAGSTFGRIAPNFLADHTGPLNMLIPAVSITAILSFVWIGVHTVPGIIVLSVLYGIFSGGFVSLPPVVMASITKDMRELGTRMGMVFAITSVGLLIGTPIGGAIMSNTHKYLGVQLFTGCAITVAAAIFLGVRLARTGVNLAVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BAD2</accession>
    <accession>C8VPH7</accession>
    <name>Q5BAD2_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">C2H2 finger domain protein, putative (AFU_orthologue AFUA_3G14090)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_02498</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF86977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_660102.1">
        <property type="nucleotide sequence ID" value="XM_655010.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BAD2"/>
    <dbReference type="GeneID" id="2875253"/>
    <dbReference type="KEGG" id="ani:ANIA_02498"/>
    <dbReference type="eggNOG" id="ENOG502SNG2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038084_0_0_1"/>
    <dbReference type="InParanoid" id="Q5BAD2"/>
    <dbReference type="OMA" id="YRCKVPA"/>
    <dbReference type="OrthoDB" id="5062908at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059009">
        <property type="entry name" value="Znf_C2H2_17_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059095">
        <property type="entry name" value="Znf_C2H2_17_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26177">
        <property type="entry name" value="zf_C2H2_17_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26176">
        <property type="entry name" value="zf_C2H2_17_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="363"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="401"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="433"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="437"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="467"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF86977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="563" mass="62192" checksum="8890776FDAE8172C" modified="2005-04-26" version="1">MASGAKTDSEHLSLSQTMLHMDHSQSRHIQGHLASRSQDDELLSQDSFSLCSSTAQSDKPWSMNDVDCLDSNSIASSKPDSPAVQMLSFSLSQHALLHSGVGASDIMYSAGSEFHGLPDVGEQAEMDFSKQDFNPYNSLFDFSAFENDVNGQNGTHPSCTPDHGSPAGDNWNPIVSDSRYNQGSMEHFSGNVFNMPVSPPLTEASNDIAVTSSCSQSGYPAFMSHEDAMLKDITTTPVGTHGINLGDPIFPLTPPLNEQDPNRTIRPSKGARRPALQVSPTRPQVKQDAEFFPPLPVKEPLRSRSKDGSESRNPRDHPYYSLPPHSDSKYYCPFATGDKPCNHPPTTQKCAYHKYLDSHLKPYRCRVPSCMDAQLHFSSNACLFRHEREAHGLHGHGDNPHLCLFEGCDRSIPGYGFPRRWNLFDHMRRVHDYASSERPSSPDASPTNQPKKKESTGRKRRVPGVSGAQTMKRTRSTQSQTNPLKAAVQQTSVHNGQNIQAAERNYYNCHRRLLEQLNNITPQDSAMHDKVNASLQELITLGITYRQAQASQAVAQIGNGIPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="109" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BAQ6</accession>
    <accession>C8VNN1</accession>
    <name>Q5BAQ6_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_02374</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF86716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_659978.1">
        <property type="nucleotide sequence ID" value="XM_654886.1"/>
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    <dbReference type="AlphaFoldDB" id="Q5BAQ6"/>
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        <property type="interactions" value="26"/>
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    <dbReference type="GeneID" id="2874732"/>
    <dbReference type="KEGG" id="ani:ANIA_02374"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN2374"/>
    <dbReference type="eggNOG" id="ENOG502S0SX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044999_0_1_1"/>
    <dbReference type="InParanoid" id="Q5BAQ6"/>
    <dbReference type="OMA" id="HAWLCLT"/>
    <dbReference type="OrthoDB" id="2898509at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
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    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
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    </dbReference>
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        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
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        <property type="entry name" value="SDR_fam"/>
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    <dbReference type="InterPro" id="IPR052228">
        <property type="entry name" value="Sec_Metab_Biosynth_Oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47534:SF3">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47534">
        <property type="entry name" value="YALI0E05731P"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF86716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="331" mass="35514" checksum="96D76800EBE45EFC" modified="2005-04-26" version="1">MDSFHVMLSHNAGIRSSLPAGIVAVFVGATSGIGAATLKAFAKYNRAPRAYFVGRSQTAADTIIAECKALNPGGEYVFIEADISLIRTVDEVCARIKARETRLDILFLSQGTASLERNKTPEGLHLLTALAHYSRTRFIANLLPLLEHASCLRRVVTVGAAGFEGPIDTSDFGALHVAPGQVRGHVATLITLGLEALARHAPSVSFIHSYPGTVDTPLTRRVMSGTGAAPVDWMNPTESGERHLYLLTSSRYPGRNEDADLAQLDGDGVSDPDVIRGTDGKLGSGVYAVGLDGECVTMETLGFLDTLRKNEMVDLVWEHTVGEFERIARAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="114" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BB56</accession>
    <accession>C8VML6</accession>
    <name>Q5BB56_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Vacuolar protein sorting-associated protein 17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ANIA_02224</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the membrane-associated retromer complex which is essential in endosome-to-Golgi retrograde transport.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the retromer complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 6">Belongs to the VPS17 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF86416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_659828.1">
        <property type="nucleotide sequence ID" value="XM_654736.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BB56"/>
    <dbReference type="FunCoup" id="Q5BB56">
        <property type="interactions" value="59"/>
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    <dbReference type="STRING" id="227321.Q5BB56"/>
    <dbReference type="GeneID" id="2875709"/>
    <dbReference type="KEGG" id="ani:ANIA_02224"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN2224"/>
    <dbReference type="eggNOG" id="KOG2273">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028982_0_0_1"/>
    <dbReference type="InParanoid" id="Q5BB56"/>
    <dbReference type="OMA" id="FYLGTME"/>
    <dbReference type="OrthoDB" id="9976382at2759"/>
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        <property type="component" value="Chromosome VII"/>
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    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
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        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005628">
        <property type="term" value="C:prospore membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030905">
        <property type="term" value="C:retromer, tubulation complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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    <dbReference type="GO" id="GO:0140318">
        <property type="term" value="F:protein transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0032120">
        <property type="term" value="P:ascospore-type prospore membrane formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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        <property type="entry name" value="BAR_Vps17p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06891">
        <property type="entry name" value="PX_Vps17p"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Vacuolar protein sorting-associated protein 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000034">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014461">
        <property type="entry name" value="Retromer_complex_Vps17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053055">
        <property type="entry name" value="VPS17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037907">
        <property type="entry name" value="Vps17_PX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015404">
        <property type="entry name" value="Vps5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47433">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47433:SF1">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09325">
        <property type="entry name" value="Vps5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF011791">
        <property type="entry name" value="Vps17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="8">
        <location>
            <begin position="118"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="478"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="72"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="563"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00060860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00073022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR011791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBF86416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="574" mass="63136" checksum="17B75E8F00519666" modified="2005-04-26" version="1">MDYSSIQQDPAGASPWASPRATEATYPPSSTSDIPPSPLPPHHESPYEAAGDSQPAEAAEHKTPGEGDVGSPSLSERVQNTHLNEAGYAAEQQPRSQVPARYQTGARQNARQPAPVYKIQAKITGLERTGKKDPILRFDVHTNIPKFRTTQYRDVRRTHSEFGKLADHLMSANPEALVPAVPAPLTPAGAGTDEDEFRVKASMQRWLNTVLNNEVLIQDDEIVLFVESDFGYSPVVRMKQPATGVRRKVLKQFAPPPDDTPELQNARPVVKMFYLGTMDASHKVDRVVKARRGLGLAESDFGVKVGQMHVQETHPGLSNAYRKLGKVIQAVGDYHAVQATAEATTLGDPLSYHSSDAFIVKETLTNRHILLRELLQAQQATRSKRAAADRLKVSSSVRPEKVDEAISALDEAQSQEDYLTKKTQRVTSNLLNEKRRWFERTSNDVWLALREYTLRQIEAERRTLATLESVRPDIRSIDASGGLSRLGRESHPTGRRPNLASSQGPKGDAWSGIPRRSDSLGRSLSGSFAAPAPEEDEETNGRLRSPSGVSSIVEDDDDRLDARNAASRLAGSTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BBB1</accession>
    <accession>C8VMA3</accession>
    <name>Q5BBB1_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">SNARE complex subunit (Syn8), putative (AFU_orthologue AFUA_2G15820)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">ANIA_02169</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF86308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_659773.1">
        <property type="nucleotide sequence ID" value="XM_654681.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BBB1"/>
    <dbReference type="FunCoup" id="Q5BBB1">
        <property type="interactions" value="259"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5BBB1"/>
    <dbReference type="GeneID" id="2875648"/>
    <dbReference type="KEGG" id="ani:ANIA_02169"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN2169"/>
    <dbReference type="eggNOG" id="KOG3202">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053570_0_0_1"/>
    <dbReference type="InParanoid" id="Q5BBB1"/>
    <dbReference type="OMA" id="QIHAYHS"/>
    <dbReference type="OrthoDB" id="244190at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd15859">
        <property type="entry name" value="SNARE_SYN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000060">
        <property type="entry name" value="SNARE complex subunit (Syn8)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12791">
        <property type="entry name" value="GOLGI SNARE BET1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="12">
        <location>
            <begin position="180"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="82"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="218"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="82"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="106"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CBF86308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="270" mass="30547" checksum="E60324C5A584FE9A" modified="2005-04-26" version="1">MPNPSQLFLLADHIKLSLLERERAISLSLEPNSQDGEISRSLESLREGIEGVEANVKRLEESNDEEAADIKDQLMHLRSQYSDLSSQFRGPTSSSAEGESNDRSDSASPQFTNVKGRSPDLKQPVPQHPSSKSVRFMDDSVAAEEDLNRRTLFQPYRDSPSPEGVDTSDMSNQHIYDHHERVMREQDEQLDRLGESIGRQHQLSIQIGDELDGHVALLDEMDGTVDRHQSRLDNARRRIDKIRRSAGENWSMMTIIGLIIILVILIVLLK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-05-30" modified="2026-01-28" version="130" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BBL3</accession>
    <accession>C8VLP3</accession>
    <name>STE20_EMENI</name>
    <protein>
        <recommendedName>
            <fullName>Serine/threonine-protein kinase ste20</fullName>
            <ecNumber>2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">ste20</name>
        <name type="ORF">AN2067</name>
    </gene>
    <organism>
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">MAP4K component of the MAPK pathway required for the mating pheromone response and the regulation of cell polarity and cell cycle.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1"/>
    <dbReference type="EMBL" id="AACD01000032">
        <property type="protein sequence ID" value="EAA64899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF86111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_659671.1">
        <property type="nucleotide sequence ID" value="XM_654579.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BBL3"/>
    <dbReference type="SMR" id="Q5BBL3"/>
    <dbReference type="FunCoup" id="Q5BBL3">
        <property type="interactions" value="362"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5BBL3"/>
    <dbReference type="EnsemblFungi" id="CBF86111">
        <property type="protein sequence ID" value="CBF86111"/>
        <property type="gene ID" value="ANIA_02067"/>
    </dbReference>
    <dbReference type="KEGG" id="ani:ANIA_02067"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN2067"/>
    <dbReference type="eggNOG" id="KOG0578">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_26_1_1"/>
    <dbReference type="InParanoid" id="Q5BBL3"/>
    <dbReference type="OMA" id="MVDIMKF"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008349">
        <property type="term" value="F:MAP kinase kinase kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071470">
        <property type="term" value="P:cellular response to osmotic stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043408">
        <property type="term" value="P:regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019236">
        <property type="term" value="P:response to pheromone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001402">
        <property type="term" value="P:signal transduction involved in filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01093">
        <property type="entry name" value="CRIB_PAK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06614">
        <property type="entry name" value="STKc_PAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000011">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000385">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.810.10:FF:000007">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.810.10">
        <property type="entry name" value="CRIB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000095">
        <property type="entry name" value="CRIB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036936">
        <property type="entry name" value="CRIB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051931">
        <property type="entry name" value="PAK3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033923">
        <property type="entry name" value="PAK_BD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE SAMKA-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832:SF22">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE SAMKA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00786">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00285">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50108">
        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-0589">Pheromone response</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000237630" description="Serine/threonine-protein kinase ste20">
        <location>
            <begin position="1"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="domain" description="CRIB" evidence="2">
        <location>
            <begin position="239"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="567"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="315"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="63"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="101"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="133"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="315"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="409"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="440"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="467"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="524"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3 4">
        <location>
            <position position="686"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="573"/>
            <end position="581"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="596"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="6"/>
    <sequence length="848" mass="93421" checksum="A30FA5CA2D2A544D" modified="2005-04-26" version="1">MNNDSFSSFKFRRPSSKLHKDPPGYGSRALNSQQSTTSLKRHPSAPVYPRSSAAGSREHLRTRSNAYGSSSSSLDQNSAGASPVLGSSDSGHFHSSHSSRSRPPYSGRFSLNDQSSDELIGAPFDSRGMLSALEEHTAEPDNRSYQPPDPAERYTEKPPNFRSQTTPNPRALRQSASFTTLPPRMEAFPNAAGNDRPTNTKRFSDEATPVRPPGPSRSKKSSFSSFVNSMLGSPRGIKISAPENPVHVTHVGYDNQTGQFTGLPKEWQRLLQESGITQKEQEEHPQTMVDIMRFYEKNARGDDEVWHKFDHAYPQQPTAASPISQPAGSTTYGTQRTSPPTSPRFPQNHEGSFENPRAPPPIPRAAPIAAHAMSPPLGGLVPNRAPPKPPTAAANLVPSRPAPQPPTSSPYSNISTRPSPETQSPQFSTPPIPETEPLPSESQRSRSNSRTNGAQGPWPSVSPSHYQQQQEQAMAVAQQALANKQLERSRSQRQQQQSPRPDQMPIAQPALPQHAPSPEDVALTQASQTARAAPAARPRQRPRQSNAMDVRARLVAICTPGDPTKLYYNLNKIGQGASGGVFTAYEQHTNNCVAIKQMNLDLQPKKDLIINEILVMKDSKHKNIVNFLDSYLHGLDLWVVMEYMEGGSLTDVVTFNIMSEPQIAAVCRETLNGLQHLHSKGVIHRDIKSDNILLSLDGNIKLTDFGFCAQINDSQNKRNTMVGTPYWMAPEVVTRKEYGRKVDIWSLGIMAIEMIEGEPPYLTESPLRALYLIATNGTPKIKDEHNLSPVFKDFLHFALRVDPEKRASAHDLLKHPFMNLCAPLNHLSPLVKAARISRAQEKAQKGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BC66</accession>
    <accession>C8VKG3</accession>
    <name>Q5BC66_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ASST-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_01864</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF85715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_659468.1">
        <property type="nucleotide sequence ID" value="XM_654376.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BC66"/>
    <dbReference type="STRING" id="227321.Q5BC66"/>
    <dbReference type="GeneID" id="2874747"/>
    <dbReference type="KEGG" id="ani:ANIA_01864"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN1864"/>
    <dbReference type="eggNOG" id="ENOG502SHE7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018249_2_1_1"/>
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    <dbReference type="OMA" id="ITFWAGD"/>
    <dbReference type="OrthoDB" id="5377172at2759"/>
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        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053143">
        <property type="entry name" value="Arylsulfate_ST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039535">
        <property type="entry name" value="ASST-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35340:SF6">
        <property type="entry name" value="ASST-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35340">
        <property type="entry name" value="PQQ ENZYME REPEAT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14269">
        <property type="entry name" value="Arylsulfotran_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010161328" description="ASST-domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF85715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="510" mass="56966" checksum="0E5DB176E32BBDF4" modified="2005-04-26" version="1">MARRFLAAASALLLAIEAAADNWPFMTLQTAPFQPPQVSVTKSGHTDPGYIFVGPRGNQELGTAALIYDEDANLIYQGPQEVTANFKVQKLFNEDVLTFWAGDMMKLGFGYGTVHILDNTYREIYTVTLQDNFVSPDGNPRDSYIDLHESHVTDRNTLLVTAYNVTQHDLTSIGGRPDDHMLDGKFYEIDIATNEIVFSWSALDHLDDIPLEESKQGWGDDVGSQETPYDAYHINSVELMEDGYIISLRHFWSGYFVHNNGSVLWRLSGEEGTGDFEIDDRAAFSWQHDIRIYNQTEEGFAMSLFNNANTPTNEVAATTGLSFDVDMINRKVHTRRILNDTDDVIHSVSQGSYQLLSEETQHVLLGYGSIAQVKEYDADNKEVLTVKFGEDNAVASYRGYKCQWKATPFWKPALVVRRTGPDSIFVYMSWNGATEYDNWAVYSSTYSDGSDPKFEATVERTGFESSIELHGLPSGFLQVIARKGDIPLGSSDVASLQTEVGGEVETETGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BCG6</accession>
    <accession>C8VPC1</accession>
    <name>Q5BCG6_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_01764</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF85518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_659368.1">
        <property type="nucleotide sequence ID" value="XM_654276.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BCG6"/>
    <dbReference type="GeneID" id="2875181"/>
    <dbReference type="KEGG" id="ani:ANIA_01764"/>
    <dbReference type="eggNOG" id="ENOG502SH2S">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051875_0_1_1"/>
    <dbReference type="InParanoid" id="Q5BCG6"/>
    <dbReference type="OMA" id="WRVIHLK"/>
    <dbReference type="OrthoDB" id="5425061at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018555">
        <property type="entry name" value="C630.06c-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09428">
        <property type="entry name" value="DUF2011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="278"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF85518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="307" mass="33498" checksum="57FF2A967219DA2E" modified="2005-04-26" version="1">MMFDLPDAKRVRRDDLLTRTSSSPSPSPPPESLIPDAQKRLSALLDFDFNVAPAPEPETRGTEDNELEEQEFEFRLFSSAPTPRAPSTARKESGDSPTTVAAQNAQKLRIRLRSPTPTALGSGEGGFVNPFRGWGYYFSTPELLTGTGAKGDEDVGVALKRKQFEDVAVSGEDMVKLSGVPWPGCHLPWRVICLKREHTKLPKEEKGAAPATPATTYIADVPERVPLSRKKPGKKRRIQLRKKAAAAKRAKETEAEKRNRRNREKKIKRRQKAREAKAAAAAAGAGDGAGSIAAMEANASATEQESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="108" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BCJ4</accession>
    <accession>C8VP39</accession>
    <name>Q5BCJ4_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ANIA_01736</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF85467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_654248.2"/>
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        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
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        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206:SF14">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
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    </dbReference>
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        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="21"/>
            <end position="51"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="501"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBF85467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="609" mass="67314" checksum="6E8300F6B46433FA" modified="2005-04-26" version="1">MFLTPSPHHPQCLGPLKSRRGCTACKTRKIKCDQQKPSCRRCIAARYTCEYPSQMTTSYASAPSSTTSSILDLDVDVSLGVSGSSPLGAAGVWRERRAFAYYFHHAAPYLAGGLDQSFWTVTVPRICRAETAVWDAVNAISTLFEFPEMCLDFVFLRHEKTQSSLNNKQIEALSWYSRSLSKIQSGIERGNLSVQVALVSCVLFICIEMVQGHVEEALGLYGQGVRLIHGLRARARYAPQTASDVDFRETIIVPLFLRLGTAALGISGVPVCDLLSGLDTQQKYLFSSLEDARDAIIPLAAEVQMFWRDTGRNPFIPGPGGEPAIPSSTETEAAVARAQRDRLQARLDAWFRAYTALKTLPRFTRAHQPAAKSEISTSIGAILLTFHTTLSTILATSLSQTACVYDMHVHSYRTIIEQASIALESLRKPDGTQPVFTFELGVGLPLFWTALTCREPAIRRKALNLLRISPPMQGFSKAQVGLALAGRIAELEEAFARDLLSRTPSPEGENGGALLTSPYDSFEGKEATTAVKKTDPHIPEEARIQHYAVFRPRDQPHILGPHEHDIPRWGKSPDQLFLRFTRNQWNKESGGWVLSDECVPMTPDEGYAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BCR3</accession>
    <accession>C8VNL6</accession>
    <name>Q5BCR3_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_01667</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
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            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CBF85331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_654179.2"/>
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        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="CDD" id="cd23703">
        <property type="entry name" value="mS26_PET12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058940">
        <property type="entry name" value="mS26_fungi"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26163">
        <property type="entry name" value="mS26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF85331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="285" mass="33258" checksum="0BFB14F711B276FF" modified="2005-04-26" version="1">MSLLRQSRTATVQLRGFSSSSVLRVGPESPNFIEIPRTIQPDLPPKPRVKGTLPVPRELFPKRRADKPNKQYIAAATPLPTKQETIDPDEPHAEYRSWKRSMAEMRRQNFEEGLVELHSRKLRTDKTMEDRSRERQKLRDHVLRQREREDEYLTRPSIPRDMLPKRMPVLPDPGREQRLAQSKARTEKKAAKKVAERRDALHTLYMNARHFITTESQLAAEIEKVFPEGENEAWRSDHKYGENIWNLGFPRGMASRVNENREVERWDVVQGRIKKLGEQITGGTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BDA8</accession>
    <accession>C8VME3</accession>
    <name>Q5BDA8_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">C4-dicarboxylate transporter/malic acid transport protein, putative (AFU_orthologue AFUA_8G04630)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ANIA_01472</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF84928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_659076.1">
        <property type="nucleotide sequence ID" value="XM_653984.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BDA8"/>
    <dbReference type="STRING" id="227321.Q5BDA8"/>
    <dbReference type="GeneID" id="2875511"/>
    <dbReference type="KEGG" id="ani:ANIA_01472"/>
    <dbReference type="eggNOG" id="ENOG502QV03">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030057_2_0_1"/>
    <dbReference type="InParanoid" id="Q5BDA8"/>
    <dbReference type="OMA" id="LPCREHR"/>
    <dbReference type="OrthoDB" id="2901184at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015140">
        <property type="term" value="F:malate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd09317">
        <property type="entry name" value="TDT_Mae1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.150">
        <property type="entry name" value="Voltage-dependent anion channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030185">
        <property type="entry name" value="Mae1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004695">
        <property type="entry name" value="SLAC1/Mae1/Ssu1/TehA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038665">
        <property type="entry name" value="Voltage-dep_anion_channel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31162:SF0">
        <property type="entry name" value="MALIC ACID TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31162">
        <property type="entry name" value="MALIC ACID TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03595">
        <property type="entry name" value="SLAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="204"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="288"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="327"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="360"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBF84928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="395" mass="44351" checksum="992B9AFDFE90FEAC" modified="2005-04-26" version="1">MFENVPLPQSPRSETSTIVGEEVEMKKGVQMTICERLHHFTWAWFTLTMSTGGLALLISNQPFQFQGLREIGLAVYIIDLLFFALCCFLMALRFFLHGGFLKSLRHEREGFFFPTFWLSVATIISGLYKFFGEDADESFQLALEVLFWIYCACTLTLAVVQYYFVFSSHTYHLQTMMPSWILPIFPVMLSGTIASVIAEQQPARSAIPIVCAGITFQGLGFSVAFMMYSHYIGRLMQAGLPHREHRPGMFICVGPPAFTALALVGMTAGLPEQFEILHDESSIQDARIMTLIAVSAAVFLWALSLWFFCIAVIAVIRERPTAFHLSWWAMVFPNTGFTLATITLGNWLDSTGIKGVATAMSIGIICMFLFVLVSHVRAVIRQDIMYPGKDEDVSE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-09-13" modified="2026-01-28" version="102" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BDX1</accession>
    <accession>C8VSI2</accession>
    <name>CLF1_EMENI</name>
    <protein>
        <recommendedName>
            <fullName>Pre-mRNA-splicing factor clf1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">clf1</name>
        <name type="ORF">AN1259</name>
    </gene>
    <organism>
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in pre-mRNA splicing and cell cycle progression. Required for the spliceosome assembly and initiation of the DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the crooked-neck family.</text>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="EAA65852" version="1"/>
        </conflict>
        <text>Truncated N-terminus.</text>
    </comment>
    <dbReference type="EMBL" id="AACD01000017">
        <property type="protein sequence ID" value="EAA65852.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF87839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BDX1"/>
    <dbReference type="SMR" id="Q5BDX1"/>
    <dbReference type="FunCoup" id="Q5BDX1">
        <property type="interactions" value="1025"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5BDX1"/>
    <dbReference type="EnsemblFungi" id="CBF87839">
        <property type="protein sequence ID" value="CBF87839"/>
        <property type="gene ID" value="ANIA_01259"/>
    </dbReference>
    <dbReference type="GeneID" id="2877035"/>
    <dbReference type="KEGG" id="ani:ANIA_01259"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN1259"/>
    <dbReference type="eggNOG" id="KOG1915">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011554_1_0_1"/>
    <dbReference type="InParanoid" id="Q5BDX1"/>
    <dbReference type="OMA" id="HIKVWIS"/>
    <dbReference type="OrthoDB" id="541719at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000048">
        <property type="entry name" value="Cell cycle control protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000254">
        <property type="entry name" value="Cell cycle control protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000306">
        <property type="entry name" value="Cell cycle control protein cwf4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059164">
        <property type="entry name" value="HAT_PRP39_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055433">
        <property type="entry name" value="HAT_Syf1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055430">
        <property type="entry name" value="HAT_Syf1_CNRKL1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045075">
        <property type="entry name" value="Syf1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246:SF3">
        <property type="entry name" value="CROOKED NECK-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23241">
        <property type="entry name" value="HAT_PRP39_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23231">
        <property type="entry name" value="HAT_Syf1_CNRKL1_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23233">
        <property type="entry name" value="HAT_Syf1_CNRKL1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0507">mRNA processing</keyword>
    <keyword id="KW-0508">mRNA splicing</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0747">Spliceosome</keyword>
    <feature type="chain" id="PRO_0000205745" description="Pre-mRNA-splicing factor clf1">
        <location>
            <begin position="1"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="repeat" description="HAT 1">
        <location>
            <begin position="52"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="repeat" description="HAT 2">
        <location>
            <begin position="86"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="repeat" description="HAT 3">
        <location>
            <begin position="120"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="repeat" description="HAT 4">
        <location>
            <begin position="154"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="repeat" description="HAT 5">
        <location>
            <begin position="187"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="repeat" description="HAT 6">
        <location>
            <begin position="220"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="repeat" description="HAT 7">
        <location>
            <begin position="257"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="repeat" description="HAT 8">
        <location>
            <begin position="301"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="repeat" description="HAT 9">
        <location>
            <begin position="335"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="repeat" description="HAT 10">
        <location>
            <begin position="379"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="repeat" description="HAT 11">
        <location>
            <begin position="417"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="repeat" description="HAT 12">
        <location>
            <begin position="450"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="repeat" description="HAT 13">
        <location>
            <begin position="484"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="repeat" description="HAT 14">
        <location>
            <begin position="520"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="repeat" description="HAT 15">
        <location>
            <begin position="569"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="673" mass="81657" checksum="2572011001E8A6E3" modified="2011-10-19" version="2">MEASRGPPRVKNKAPAPVQISAEQLLREAVDRQEPSLQAPTQRFADLEELHEYQGRKRKEFEDYVRRNRINMNNWMRYAAWELEQKEFRRARSIFERALDVDSTSVPLWIRYIESEMRNRNINHARNLLDRAVTILPRVDKLWYKYVYMEETLGNIPGTRQVFERWMSWEPDEGAWSAYIKLEKRYNEFERARAIFQRFTIVHPEPRNWIKWARFEEEYGTSDLVREVYGLAVETLGEDFMDEKLFIAYARFETKLKEYERARAIYKYALDRLPRSKSITLHKAYTTFEKQFGDREGVENVILAKRRVQYEEQLKENLRNYDVWFDFARLEEQSGDPERVRDVYERAIAQIPPSQEKRHWRRYIYLWIFYALWEEMEAKDIDRARQVYTECLKLIPHKKFTFAKVWLMKAQFEVRQLNLQAARKTLGQAIGMCPKDKLFRGYIDLERQLFEFVRCRTLYEKQIEWNPSNSQSWIQYAELERGLDDTERARAIYELGIDQPTLDMPELVWKAYIDFEDDEGEYERERQLYERLLQKTDHVKVWINYARFEINVPDEEEEEEEEERPISDEAKRRARAVFERAHRVFKEKELKEERVELLNAWRAFEHTHGSPEDIDKIEKQMPRRVKKRRKLDDDRYEEYMDYVFPADDQSAANLSKLLRMAHQWKQETAGGQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BDZ1</accession>
    <accession>C8VSQ1</accession>
    <name>Q5BDZ1_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF218 domain protein (AFU_orthologue AFUA_7G01750)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_01239</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF87874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_658843.1">
        <property type="nucleotide sequence ID" value="XM_653751.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BDZ1"/>
    <dbReference type="GeneID" id="2877014"/>
    <dbReference type="KEGG" id="ani:ANIA_01239"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN1239"/>
    <dbReference type="eggNOG" id="ENOG502RYVR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084257_0_0_1"/>
    <dbReference type="InParanoid" id="Q5BDZ1"/>
    <dbReference type="OMA" id="WPTFVPK"/>
    <dbReference type="OrthoDB" id="17725at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd06259">
        <property type="entry name" value="YdcF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3620.10">
        <property type="entry name" value="YdcF like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051599">
        <property type="entry name" value="Cell_Envelope_Assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003848">
        <property type="entry name" value="DUF218"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30336:SF20">
        <property type="entry name" value="DUF218 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30336">
        <property type="entry name" value="INNER MEMBRANE PROTEIN, PROBABLE PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02698">
        <property type="entry name" value="DUF218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF218" evidence="1">
        <location>
            <begin position="99"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF87874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="270" mass="30411" checksum="18DF2DB89F1EA0C9" modified="2005-04-26" version="1">MLAVSPKIVADINLLAGYLSYPQLQLEDLSSISPADSIIICASMILHQAESLFHALQENPSLTKTLVLCGGIGHSTQYIYEAVAQHSRFSSISNDIQHLPEAWVLERILDTFFDRAVITSQGCRILIEDRSTNCGENALFSRKVLDDAGLHNLHRCVLIQDPTMMRRTVASFQKAYEERTEMPLFLSCPLLVPQVEGSKEPGGNLRYAMSEVRLWPLERFISLTLGEIPRLRDDEDGYGPRGRNFISHVKVPVDIEAAWTRLRASFNTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="113" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BEU2</accession>
    <accession>C8VUI4</accession>
    <name>Q5BEU2_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS quinate transporter, putative (AFU_orthologue AFUA_1G16230)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ANIA_00938</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF88489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_658542.1">
        <property type="nucleotide sequence ID" value="XM_653450.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BEU2"/>
    <dbReference type="GeneID" id="2876702"/>
    <dbReference type="KEGG" id="ani:ANIA_00938"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_12_1"/>
    <dbReference type="InParanoid" id="Q5BEU2"/>
    <dbReference type="OMA" id="MQTIAQW"/>
    <dbReference type="OrthoDB" id="508119at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF43">
        <property type="entry name" value="QUINATE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G16230)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="102"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="133"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="262"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="304"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="329"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="371"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="403"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="436"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="20"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBF88489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="491" mass="54709" checksum="1782B72B1B598878" modified="2005-04-26" version="1">MRRLELDRSRWTTPSFYAFVILVIACGSIPKGYDEGGYSASVRLYSFKADFNLLDSNWTNNETGLANRVANITSFNVLGAALGALVSLDLNDRLGRLRSWQLACAVWMSGTFIQVFASGMYGLLLFARIWGGLGAGALTVATPLYLSEIGFFINYGANIHMSPTRSQYRLVQSIPLIPVGVAFGASTMIPETPRYLVSKSRLEEGRNVLARLRGLDALSPKIEEEFSLITTQARFRADTLSSISNWTAFKETQSNPNYRQRFWLLMAMQTISQWTGGNGITYYVSTIFESAGVTGNATSLVSSGAYGVVKLVFTMAFTWGLIDFLGRRYCVLLGLTLQLAAHVYLACYMGVLRPSDDTELVNKPASNTAIAAVFIYAIGWSIGLCTVPYLYGTEIFPTRIRNVSYAVSMSLHWFFQFAVVRVTPNMFVSLHDWGAYMFWAIICFVGLVVLGIWMPETKGVDIELMGELFEGPWYLRWRARVRPKNGEQTGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BEX6</accession>
    <accession>C8VUR8</accession>
    <name>Q5BEX6_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_00904</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF88554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_658508.1">
        <property type="nucleotide sequence ID" value="XM_653416.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BEX6"/>
    <dbReference type="GeneID" id="2876680"/>
    <dbReference type="KEGG" id="ani:ANIA_00904"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN0904"/>
    <dbReference type="eggNOG" id="ENOG502SGBF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016094_0_0_1"/>
    <dbReference type="InParanoid" id="Q5BEX6"/>
    <dbReference type="OMA" id="KGCHTFT"/>
    <dbReference type="OrthoDB" id="5422351at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40625:SF1">
        <property type="entry name" value="AMP-ACTIVATED PROTEIN KINASE GLYCOGEN-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40625">
        <property type="entry name" value="GTP-BINDING PROTEIN ESDC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010299498" evidence="2">
        <location>
            <begin position="20"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="333"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="482"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="483"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF88554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="634" mass="70238" checksum="32F756CEE9320357" modified="2005-04-26" version="1">MTSTTLMTFLLCTSPNVRSVTLLGSWDNFSKPYVMERDKRVGAGHWRGCHTFTNITCDGLVNNTVSARSGGLKMGATYWYYYLLDDDIEYYNEAEPMTTHCPFLPGQPVNVLQVPIILPDTHLNRTRARSPSAHRTVQTMNPEDKYMNPREPPKPKLRLRTSPPLLQTHTPNWPFSTSPLGASTSRGPAQPGHGTQKVKHPRDEAKASRSVSPPRSKGLRAAFRQWNTSTSSFSPTNDQHGGFERQARVHAHLRPPVDDRYHVRSQSNDSYMRSPSMGNLPEHHREDGLPFRRPISAGTHGSGSLSIQERRALNTKSPHDFTPRIPLTLRPKQPWVTPVNASDHSMPSPLMRRPLSTPSTPSMLRRPSDDSQSYKESMTPTPVAVMNKRLPTLPNSPSSVMDEALRDLDEKERALDMEALASHFSTFTEPDSVDGDGPCEKSRFSEWSTDTDMVSPESVTSCLTFNEKEGSLNVPAIGLSELSDASTDNAPSDPNTPHLTVGSKSPAHHEDSPRMELPVPRLTIALSPSDLNIPGLCIDEEDEELLESNPKRHAAFFGAMELKGLGLTSPPATTLHFPEGVQDASPDRNITPTNDPSRYSVLLSQSATMKEMIDELSYLKNMIQSGSVPDLTED</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BG10</accession>
    <accession>C8VSV4</accession>
    <name>Q5BG10_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ANIA_00520</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF89318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_658124.1">
        <property type="nucleotide sequence ID" value="XM_653032.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BG10"/>
    <dbReference type="GeneID" id="2876295"/>
    <dbReference type="KEGG" id="ani:ANIA_00520"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN0520"/>
    <dbReference type="eggNOG" id="KOG1231">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_897227_0_0_1"/>
    <dbReference type="InParanoid" id="Q5BG10"/>
    <dbReference type="OrthoDB" id="2151789at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF53">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="47"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="162"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBF89318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="310" mass="34382" checksum="48A0480386D3B8DE" modified="2005-04-26" version="1">MASLSLNQLRATQRLCLHLNKDYPDFTFLQTTPQYHILSMENWSKTAWANPTCIVRPANTSVLQDTVRLLSSHYVPFAVRSGDHMPPPLGANINAGVLISLSSLDEKNYDPERDVIEVGGGLKWRDVYSYLDEYKVTVVGGRVLESEWGFLYSEQISKSSLPTVPWSTPTDHPIKTSSVPSKAGPITSVRISKQIRLPGLNYLQASSRHLLCTPTPSTLFENMLGHLPRLLTAAYEFQQSDAAEGHAKFMLQAFIAGGTISAVMNMIYIQPEPNPSAFAPFASISTVDDLTRIQTLTKMMSGQMVPDNHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BG38</accession>
    <accession>C8VSY6</accession>
    <name>Q5BG38_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cyanovirin-N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_00492</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF89375.1"/>
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        <property type="nucleotide sequence ID" value="XM_653004.1"/>
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    <dbReference type="GeneID" id="2876271"/>
    <dbReference type="KEGG" id="ani:ANIA_00492"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN0492"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_1825255_0_0_1"/>
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    <dbReference type="OrthoDB" id="2112446at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39603">
        <property type="entry name" value="CYANOVIRIN-N DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39603:SF1">
        <property type="entry name" value="CYANOVIRIN-N DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010164941" description="Cyanovirin-N domain-containing protein" evidence="1">
        <location>
            <begin position="25"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF89375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="141" mass="14744" checksum="315E1BBBB0D2616F" modified="2005-04-26" version="1">MPSTSPISIVYFTALLGLVSTTLAFPTFTPTEPLSKRIALTCNNDGGLYRPVSEAQACVDYLLTKSTDDCVVSGDETVFCQAGDTVITGSRTGKGGESSLCRDVAKGAQRIIDSCTTPEGYVGGFNAAEGNGALIVSIHRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BGT1</accession>
    <accession>C8VUK5</accession>
    <name>Q5BGT1_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F-box domain protein (AFU_orthologue AFUA_1G05330)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_00249</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF89882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_652761.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BGT1"/>
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    <dbReference type="KEGG" id="ani:ANIA_00249"/>
    <dbReference type="eggNOG" id="ENOG502SFSP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020490_2_0_1"/>
    <dbReference type="InParanoid" id="Q5BGT1"/>
    <dbReference type="OMA" id="HYVIYIW"/>
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    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
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    <dbReference type="Pfam" id="PF12937">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
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        <property type="match status" value="1"/>
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        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="9"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CBF89882.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
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    <sequence length="506" mass="58507" checksum="D1B35617E90CFAF0" modified="2005-04-26" version="1">MPDSQTSHGLDLPLLPHELFCMVLDYLDPSEIVRCRRVSRLWNEAFGDPAILIPLLKKLFPLAEEVRELYGRHGLLEDSKNSENWRLLFDRIASRYDHLTRGKPRSIRRLRLCEEFGISGEREWFQVQPWDIHASHLMQRVDLPFSESFWSYDEGLLVYPSADHACLVLMDLDSGREFMVPFIITGKVIRRVRLQRQVLVVEWAEPKAFHWLNDSDGVHRHFASSFDVRKESSRWSITFRNEWKIMFLGHPLSERDRFYSTHSQTHYAIYIWQPNRSLYTADEDAPIESLSIWDISKPSSYRPSLDPTGRLRVDGEESGPSIVSRFGFRELGFYSVRQRGLPGIQWLNITEDNQSIEIFENLCTGPVDRFVGPAEWTSQVQVTSIPVNGYGPCYRQNLDLILPPYRGNSSLQASPLTLKVCEEPWYTTISESWDGKAQVGFCLHLSQATWPFDLKASLSIRTPSSAVTLKHADVFELTGKGKICGTERYLLGENGNRELLIYRFDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BGV0</accession>
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            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
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    <reference evidence="14" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
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            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CSC1 (TC 1.A.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF89927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_657833.1">
        <property type="nucleotide sequence ID" value="XM_652741.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BGV0"/>
    <dbReference type="FunCoup" id="Q5BGV0">
        <property type="interactions" value="155"/>
    </dbReference>
    <dbReference type="GeneID" id="2876007"/>
    <dbReference type="KEGG" id="ani:ANIA_00229"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN0229"/>
    <dbReference type="eggNOG" id="KOG1134">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002458_2_1_1"/>
    <dbReference type="InParanoid" id="Q5BGV0"/>
    <dbReference type="OMA" id="DPTQVIW"/>
    <dbReference type="OrthoDB" id="1076608at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005227">
        <property type="term" value="F:calcium-activated cation channel activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045122">
        <property type="entry name" value="Csc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003864">
        <property type="entry name" value="CSC1/OSCA1-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027815">
        <property type="entry name" value="CSC1/OSCA1-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032880">
        <property type="entry name" value="CSC1/OSCA1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022257">
        <property type="entry name" value="PHM7_ext"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018:SF26">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G10920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
        <property type="entry name" value="PROBABLE MEMBRANE PROTEIN DUF221-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14703">
        <property type="entry name" value="PHM7_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12621">
        <property type="entry name" value="PHM7_ext"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02714">
        <property type="entry name" value="RSN1_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13967">
        <property type="entry name" value="RSN1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="395"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="444"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="490"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="538"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="585"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="613"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="655"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="679"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like N-terminal transmembrane" evidence="11">
        <location>
            <begin position="17"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like cytosolic" evidence="12">
        <location>
            <begin position="190"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like 7TM region" evidence="9">
        <location>
            <begin position="401"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="domain" description="10TM putative phosphate transporter extracellular tail" evidence="10">
        <location>
            <begin position="775"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="263"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="731"/>
            <end position="753"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF14703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CBF89927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="875" mass="97018" checksum="3E2F3CD4FAE420FC" modified="2005-04-26" version="1">MADSENPQAASNSASSLVTVLVPSLVVAGAMVLIFVILRRSERRMYMPRTYLGVLRDSQKTPPSSTGPLGWIKDMYKLPDEYVLQHHSMDAYLLLRFLKIITMICFVGSCLTFPILFPVNATGGAGKQQLDILSFSNVSETKYARFFAHALVAWVFVAFVFFTVTRESLFYINLRQAYSLSRSYASRLSSRTVLFTTVPEEYQSVEKIRFMFGANKVKNVWLTTDTAELAEKVNDRHAAAIKLEAAETKLIRMANAARLKALKKNRGTGEQSTAPEATEDDGESGSVAARWVRPKDRPTHRLKPIIGKKVDTINWARSEIERLTPEIEALQTQHRAGEAKLVSSVFVEFHTQADAQAAFQSVAHNLPLHMAPRYIGLEPTQIIWSNLRIKWWERIIRYGASVAFVSAMVIFWAIPTAFVGSLSNINNLTDKVHFLRFINDVPDWILGAITGLLPTILMAVLMALVPIVLRLMAKIGGAPNLAAVELSTQNFYFFFQVVQVFLVVTLSSAATSVVTKIVSNPTSATSLLANNLPLSANFYISYIVLQGLSFSSGALLQISGLILGKILGRLLDNTPRKMYSRWSNLAGLGWGTVYPVFTLLAVIAITYSCIAPLVLGFATIGLYLFYFAYRYNLLYVSNADIDTQGKTFARALQQILVGCYLLVVCLIGLFAIGTGTDPIALGPMILTIILLVTMIIYHVSLNAALDPLINYLPRNLEAEEEALLSQETNGAKDEYDGSASPSAADGQTADNVDSAEKGLTQANPAEPKTNFLTKYLRPDKYSGYRQLRTLVPNGTETVSYPPEVERNAYYHPAISAQAPLLWIPRDEMGISAQEVAHTSRVIPITDEDAWLDEKNHIVWNVEKGVPPIFEEKIYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="109" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BHE4</accession>
    <accession>C8VRE8</accession>
    <name>Q5BHE4_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">D-xylose 1-dehydrogenase (NADP(+), D-xylono-1,5-lactone-forming)</fullName>
            <ecNumber evidence="3">1.1.1.179</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">D-xylose-NADP dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ANIA_00036</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>D-xylose + NADP(+) = D-xylono-1,5-lactone + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22000"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15867"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.179"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfo/Idh/MocA family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.179" evidence="3"/>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF90331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_657640.1">
        <property type="nucleotide sequence ID" value="XM_652548.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BHE4"/>
    <dbReference type="FunCoup" id="Q5BHE4">
        <property type="interactions" value="318"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5BHE4"/>
    <dbReference type="GeneID" id="2875811"/>
    <dbReference type="KEGG" id="ani:ANIA_00036"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN0036"/>
    <dbReference type="eggNOG" id="KOG2741">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023194_7_2_1"/>
    <dbReference type="InParanoid" id="Q5BHE4"/>
    <dbReference type="OMA" id="YWCCTQL"/>
    <dbReference type="OrthoDB" id="2129491at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047837">
        <property type="term" value="F:D-xylose 1-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050984">
        <property type="entry name" value="Gfo/Idh/MocA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055170">
        <property type="entry name" value="GFO_IDH_MocA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22604">
        <property type="entry name" value="OXIDOREDUCTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22604:SF105">
        <property type="entry name" value="TRANS-1,2-DIHYDROBENZENE-1,2-DIOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22725">
        <property type="entry name" value="GFO_IDH_MocA_C3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="6">
        <location>
            <begin position="11"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="GFO/IDH/MocA-like oxidoreductase" evidence="7">
        <location>
            <begin position="155"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00042988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF22725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBF90331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="366" mass="39859" checksum="D93239A0154F4A44" modified="2005-04-26" version="1">MESQKESLPTLRWGIIGAGLISSWFTKDISLPRKSPAAVHKIQAIGSSSLEKGRVFVETHLATLNPKPTVYSNYGDVYNDPEVDIVYIGTPHGLHKQHCLDAIAAGKHVLCEKAFTLNATEGREVLAAAQAKGVFIMEAMWTRFQPLVSKLKHVLFQEKAIGDVRRTFCDFGLDKDIASLPSTSRLRDPAMGAGSLLDIGIYALTWGLLTLESDPAKSERPRVVAAQTLRDGVDIATSFILHYPSTGRQGILTSTTEARTPEIFMRIEGSNGYITVEGIAASAPRAFTVYPKVEGRSLGADTGADGRRYDFELEGMGFSFEADTVAKSISQGKLENEVMSHSETVRVLEILDEIRTQGGARFPGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2025-10-08" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>C8V0K0</accession>
    <name>C8V0K0_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Amidase (Eurofung)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ANIA_10833</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the amidase family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF70903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_664123.2">
        <property type="nucleotide sequence ID" value="XM_659031.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V0K0"/>
    <dbReference type="FunCoup" id="C8V0K0">
        <property type="interactions" value="48"/>
    </dbReference>
    <dbReference type="STRING" id="227321.C8V0K0"/>
    <dbReference type="GeneID" id="2870674"/>
    <dbReference type="KEGG" id="ani:ANIA_10833"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN10833"/>
    <dbReference type="eggNOG" id="KOG1212">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009600_9_2_1"/>
    <dbReference type="InParanoid" id="C8V0K0"/>
    <dbReference type="OMA" id="MDQYYTA"/>
    <dbReference type="OrthoDB" id="6428749at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043605">
        <property type="term" value="P:amide catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072:SF2">
        <property type="entry name" value="AMIDASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072">
        <property type="entry name" value="AMIDASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001221">
        <property type="entry name" value="Amidase_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="5">
        <location>
            <begin position="78"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="3">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="3">
        <location>
            <position position="208"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="3">
        <location>
            <position position="232"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="229"/>
            <end position="232"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBF70903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="543" mass="60545" checksum="380F92DEADDAA052" modified="2009-11-03" version="1">MGSLQPWEQTVAKKRALRDQALNPYFVSDIDNRPPRVRSVSNRSCLEHDPLVQEITNIDNIPALVEQLRKGRFTAEQVTFAYIRRATVAHQLTNCITEVIFNDALAQARELDKVFKATGKLIGPLHGVPVTVKDQFNVKGYDSTIGYVGRSFSPASEDAVLVQMLKKMGAIILAKTNLPQSIMWAETENPLWGLTINPRDPALTPGGSTGGEAALLALHGSILGFGTDIGGSIRIPQSILGLYGFKPSSGRLPYRGVPVSTEGQEHVPSSVGPMARDINSIYYITRLLTSSRPWDLDPRCANLPWNESVFRGIQSRPLVIGLILDDGVVKIHPPIERAMRELAAKLEANGHELVTWNTSDHLKCISLMDRYYTVDGGEDVRRDVAVAGEPFIPHVEALVNRGKPISVYEYWQMNTERNNLQKKYLDGWNAARSPSGKPVDVLLSPTMPHVAVPHRSVRWVGYTKIWNLLDYPAITFPVDRVRADKDVLPPDYRPRNDLDAWNWSLYDAEAMEGQPVNLQVIGKRLEEESLLGAATVIERIWRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>C8V1I8</accession>
    <name>C8V1I8_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH-ubiquinone reductase complex 1 MLRQ subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_10803</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF69844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="XP_050466953.1">
        <property type="nucleotide sequence ID" value="XM_050611508.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V1I8"/>
    <dbReference type="GeneID" id="74896611"/>
    <dbReference type="KEGG" id="ani:ANIA_10803"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN10803"/>
    <dbReference type="eggNOG" id="ENOG502SUWQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_171231_2_0_1"/>
    <dbReference type="InParanoid" id="C8V1I8"/>
    <dbReference type="OMA" id="PTRVLRM"/>
    <dbReference type="OrthoDB" id="202195at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
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    <dbReference type="InterPro" id="IPR010530">
        <property type="entry name" value="B12D"/>
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    <dbReference type="Pfam" id="PF06522">
        <property type="entry name" value="B12D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF69844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="82" mass="9160" checksum="B9749CA0C7136DAC" modified="2009-11-03" version="1">MYPSPILRMQPTRPSFALPKEGQSAHTISQRLRTLKKIPPELLPLGLVLGVAVGAAIYSSTKKLMTDKTLRLTPNRPEDREH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>C8V284</accession>
    <name>C8V284_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ANIA_11528</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF71472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467171.1">
        <property type="nucleotide sequence ID" value="XM_050611116.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V284"/>
    <dbReference type="GeneID" id="74897100"/>
    <dbReference type="KEGG" id="ani:ANIA_11528"/>
    <dbReference type="HOGENOM" id="CLU_2469066_0_0_1"/>
    <dbReference type="InParanoid" id="C8V284"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF71472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="88" mass="10078" checksum="FDC297D98879BE0C" modified="2009-11-03" version="1">MGRIYVQSRCQTGDLSDYHSSARCRMESLLTCSTREEYFHLIELLEAHETPKIAESDLEDSFLHADLVPVVKVQDLDHGEAVYDDSNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>C8V2I8</accession>
    <name>C8V2I8_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Arylsulfatase, putative (AFU_orthologue AFUA_5G12940)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ANIA_06847</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the sulfatase family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF71582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467181.1">
        <property type="nucleotide sequence ID" value="XM_050611126.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V2I8"/>
    <dbReference type="STRING" id="227321.C8V2I8"/>
    <dbReference type="GeneID" id="2870546"/>
    <dbReference type="KEGG" id="ani:ANIA_06847"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN6847"/>
    <dbReference type="eggNOG" id="KOG3867">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006332_11_1_1"/>
    <dbReference type="InParanoid" id="C8V2I8"/>
    <dbReference type="OMA" id="QARYMEI"/>
    <dbReference type="OrthoDB" id="103349at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004065">
        <property type="term" value="F:arylsulfatase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16025">
        <property type="entry name" value="PAS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000044">
        <property type="entry name" value="Arylsulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1120.10:FF:000005">
        <property type="entry name" value="Arylsulfatase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050738">
        <property type="entry name" value="Sulfatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42693">
        <property type="entry name" value="ARYLSULFATASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42693:SF46">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_5G12940)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00149">
        <property type="entry name" value="SULFATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase N-terminal" evidence="8">
        <location>
            <begin position="7"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBF71582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="616" mass="69573" checksum="782A91DE531BAAC6" modified="2009-11-03" version="1">MAPVKRPNFLVIVADDLGFSDIGCYGSEIRTPNIDKLAQKGVRFTDFHAAAACSPTRAMIMTGTDHHIAGLGNLIEWTNISGQNGPKGSSTDTAPQRGMPGYEGYLNERVVALPEILRDAGYHTLMSGKWHLGLTPERSPYKRGFDRSLAHLPACSNHYAYEPQLRDQDETPTFLEASYIALHMEDDKYVRSLPEGWYSSNGYGDKMREYLVDWHKNKKEDEDKPFFAYLPFTAPHWPLQAPREYIDHYRGVYDDGPDALRLKRLASLKKLGMIREDVQPHPVVVDEGEGKPWEELTPEEKKLSCRAMEVFAGMVECIDANVGKIVDYLDSIGELDNTFVCFMSDNGAEGAAYEAYPLVQSGVLPHLLKYYNNSYENLGNGDSFIWYGPRWAQAATAPSRLYKAYTTEGGVRVPFLARFPSSTKTAPQASNGAITDQFATVMDLAPSILSMAGVAHPAPTYQGREVVSMRGKSFHAWATGASERIHEKDFIQGWETCGRAALRFGDWKIVYIPKPKGPERWQLYNLVEDPGEINDLAEKYPERLQKLLKLWDQYVLETGVIPLNPDLGDFLEATEAQMTENAWMEYDYWKAGARDDPGREKFMRKPPRFQRVVKQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>C8V2L9</accession>
    <name>C8V2L9_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DUF676 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ANIA_06088</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the putative lipase ROG1 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF70209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467009.1">
        <property type="nucleotide sequence ID" value="XM_050612013.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V2L9"/>
    <dbReference type="STRING" id="227321.C8V2L9"/>
    <dbReference type="GeneID" id="2870929"/>
    <dbReference type="KEGG" id="ani:ANIA_06088"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN6088"/>
    <dbReference type="eggNOG" id="ENOG502SJBC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002786_0_0_1"/>
    <dbReference type="InParanoid" id="C8V2L9"/>
    <dbReference type="OMA" id="WTFYETI"/>
    <dbReference type="OrthoDB" id="361039at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005655">
        <property type="term" value="C:nucleolar ribonuclease P complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007751">
        <property type="entry name" value="DUF676_lipase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039182">
        <property type="entry name" value="Pop1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22731:SF4">
        <property type="entry name" value="DUF676 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22731">
        <property type="entry name" value="RIBONUCLEASES P/MRP PROTEIN SUBUNIT POP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05057">
        <property type="entry name" value="DUF676"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="941"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="976"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1012"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="domain" description="DUF676" evidence="9">
        <location>
            <begin position="61"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="324"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="378"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1133"/>
            <end position="1161"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="888"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="329"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="417"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="427"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1143"/>
            <end position="1161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBF70209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="1161" mass="131588" checksum="9EADC9714C5069F9" modified="2009-11-03" version="1">MAGDIITNVDIVAIPAIGADRGGAWTGEDTQSPWLTTELRRFIPNARVLLLDHGELGVEDTLDSLATRLLNKLQEARKSTSRRRPIFFICHSTGGVVATAALVKASRSPSPLDSVFSSCYGIAFFGTPHYGSSYLSAPEFGRSIHRLLRLKHTIPTGLRETFKPRHEQLQRLAGQFRAISADMKIWTFLETVDSVFTITDTETGSTIDMHVPITSIRSGLLGFEHESELPLATDHVGTASFKGQEATARMDFIRDLQSSISTALELSIMSDVPLQVEQEVMVHVNGFFEDTARGVSRESPLQLWSTKTPLEQFLETGPTKCLEERLKTSTRLSSGTLDSDTSDFSRPTSAPAELSQIDSRLRDPDIISLEVVPSRPSVKRSRSFLAQHPSQQQPSPRIHVTEPPIEGYFDIQSEGSASERRISHEDSGDEGTENDEIEASDNLGTISPSQRNLLSSLSSRYREFLNVPFMERTPEERPRMIPRFDRPEPGTEKMIWVHVPYTHTDWVPAVLSKTCKGKTKQNLFRKLVNPDNWYSNLITARHLEPHARYVRPACIHFKLDSPPIKASEPHDPQLALYLHWDTYWNLLQRRRVIEERLRQGRSRPVPDDISRSSLESKLIWKYLGNEPPIHIRRTLDQFGYPNLRSTVARDDDQMLWKRTRKAINLVDELGNSLPLHDRSDLQSSVFVDGKVLMVDQLWLWIVDQKTVVTFFPKQEPTTVEGKFYEQTNLFNSIYNELNGDLARRFETAGDLAALIVLHAVTVLFDRTLHSDLQILRIFEESISILTELTTKSFKQFRNRGFVTRPAEYNKTREGRIMTAAEREERDREVAQQNRNDLSSMLELRDIVDELGTIMKLLEQQTSTINDMAKYFEHRGYGKRFILASLARLDEYRTHISEMRENAIAAQKAVENLLDLKQKQANVDESRLARWEAEVTQSQSRAVMVFTIFTVIFLPLSFFTSLFGINAREWSGEPTNLTLQTMLIIAGPTSIAVIVSALLIAFSERLRDTLLKFQKIIFGLCKDLIFTPLAAFFHQTYQRDQKSPRRSKSSLASTTKTSKTSRIGDRFGRYLASWRYRGDTEEDFWRRDDEREKGGYSSSATASNLNGAGYVARRTEGTGEGMTLPSVLVSEASGHAASNGHGGYVDRMRGPLDGMVRERHPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>C8V2R8</accession>
    <name>C8V2R8_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ANIA_06083</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL16 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF70221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467011.1">
        <property type="nucleotide sequence ID" value="XM_050612022.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V2R8"/>
    <dbReference type="FunCoup" id="C8V2R8">
        <property type="interactions" value="974"/>
    </dbReference>
    <dbReference type="STRING" id="227321.C8V2R8"/>
    <dbReference type="GeneID" id="2870861"/>
    <dbReference type="KEGG" id="ani:ANIA_06083"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN6083"/>
    <dbReference type="eggNOG" id="KOG0857">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084051_0_0_1"/>
    <dbReference type="InParanoid" id="C8V2R8"/>
    <dbReference type="OMA" id="HHVIREN"/>
    <dbReference type="OrthoDB" id="10258869at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd01433">
        <property type="entry name" value="Ribosomal_L16_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.300:FF:000002">
        <property type="entry name" value="60S ribosomal protein L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1170.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.10">
        <property type="entry name" value="Ribosomal protein L10e/L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047873">
        <property type="entry name" value="Ribosomal_uL16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018255">
        <property type="entry name" value="Ribosomal_uL16_CS_euk_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016180">
        <property type="entry name" value="Ribosomal_uL16_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001197">
        <property type="entry name" value="Ribosomal_uL16_euk_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036920">
        <property type="entry name" value="Ribosomal_uL16_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003239">
        <property type="entry name" value="PRK04199.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00279">
        <property type="entry name" value="uL16_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11726">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00252">
        <property type="entry name" value="Ribosomal_L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005590">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54686">
        <property type="entry name" value="Ribosomal protein L16p/L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01257">
        <property type="entry name" value="RIBOSOMAL_L10E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBF70221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="221" mass="25479" checksum="CD361A11E8AD7B90" modified="2009-11-03" version="1">MARRPARCYRYCKNKPYPKSRFNRGVPDPKIRIFDLGRKKANVDDFPLCVHLVSNEYEQLSSEALEAARICANKYLVKIAGKEGFHLRVRVHPFHVIRINKMLSCAGADRLQTGMRGAFGKPQGKVARVNIGQIILSVRTRDSHRATAIEALRRSMYKFPGRQKIIVSKNWGFTPVRREDYVQLRQEGKLKQDGAYVQFLRGHGQIEENMRRFPDAYSTEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>C8V3U0</accession>
    <name>C8V3U0_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_11408</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF75651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_050611469.1"/>
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    <dbReference type="AlphaFoldDB" id="C8V3U0"/>
    <dbReference type="GeneID" id="74896999"/>
    <dbReference type="KEGG" id="ani:ANIA_11408"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN11408"/>
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    <dbReference type="InParanoid" id="C8V3U0"/>
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        <property type="component" value="Chromosome II"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
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        <location>
            <begin position="17"/>
            <end position="29"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF75651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="84" mass="9032" checksum="8063074819AD7D0B" modified="2009-11-03" version="1">MRRSYRGPIKTAADGEAAEKLDQGDRSEKSACTGHLGSERSTSSGSRESRRQSLPPRLGECHAACQCHSGQVEDVDEDAGARNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>C8V617</accession>
    <name>C8V617_EMENI</name>
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        <recommendedName>
            <fullName evidence="6">CENP-V/GFA domain-containing protein</fullName>
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    <gene>
        <name evidence="7" type="ORF">ANIA_11039</name>
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    <organism evidence="7 8">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF73782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467244.1">
        <property type="nucleotide sequence ID" value="XM_050611194.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V617"/>
    <dbReference type="GeneID" id="74896742"/>
    <dbReference type="KEGG" id="ani:ANIA_11039"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN11039"/>
    <dbReference type="eggNOG" id="ENOG502RZVZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079143_2_0_1"/>
    <dbReference type="InParanoid" id="C8V617"/>
    <dbReference type="OMA" id="DINFTHG"/>
    <dbReference type="OrthoDB" id="9970124at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1590.10">
        <property type="entry name" value="glutathione-dependent formaldehyde- activating enzyme (gfa)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337:SF40">
        <property type="entry name" value="CENP-V_GFA DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337">
        <property type="entry name" value="GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
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        <location>
            <begin position="66"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="199"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="215"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBF73782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="228" mass="26332" checksum="677BC3F21EDD8E5C" modified="2009-11-03" version="1">MLYSRLLSSSSRALNTFNTRCFPINTRYLSYSRRLYKPAMPEKDPGYKDRPPYKIRSDEEFGPVKWRASCNCGQVTYKISREQPLNAKYCHCRGCQVTHGAPFQWCAVFHKSDLQFNKGTEGLSFYSSQDKSRDYQLPTKVACAHCRSPILDEGKNVCLIFPELIDYEGSGTDHETWRKAFESKMHIFYSARTMDIPDGKPKWAGMDEQSEALDDYGKPKNKDDNSRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>C8VBK9</accession>
    <name>C8VBK9_EMENI</name>
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        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ANIA_07523</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF79559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467977.1">
        <property type="nucleotide sequence ID" value="XM_050612014.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VBK9"/>
    <dbReference type="GeneID" id="2869677"/>
    <dbReference type="KEGG" id="ani:ANIA_07523"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN7523"/>
    <dbReference type="eggNOG" id="ENOG502SHAY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028200_3_4_1"/>
    <dbReference type="InParanoid" id="C8VBK9"/>
    <dbReference type="OMA" id="FHCTPIQ"/>
    <dbReference type="OrthoDB" id="5022096at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF31">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="205"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="6"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="280"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="310"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBF79559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="328" mass="36127" checksum="D9A28B5B87576D77" modified="2009-11-03" version="1">MAISADDAPKLAGSVIALTSLALITYSLRVYCRVSRRLWAAEDWIMTAAVFFLIFEVGYCAAIIPIKLSISWMLIRIAEGRKLYIYIQYIIIALFTIMNVIALIFILTDCIPVEAAWDKSLLKNGGRCQPPQVLADVYYACTAVNITTDWVTALMPIPLLWNVQLGRNSKLSVMGLMSLGILASLSACVRLNYTVNLTNQDEFLYAVANVVIWGFAENAIGMTVGNIATLRPLFRTLFESTGRSGYSSRPSRLESGFELSQQGKGTAAYTYTTTLTEVKGAQAQSGRESKDQDSQLSDSDSQKMILEGNKTGQGNNIMVSRQVNVSYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>C8VBW7</accession>
    <name>C8VBW7_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DUF323 domain protein (AFU_orthologue AFUA_2G15650)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ANIA_10996</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; ergothioneine biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF79758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_680889.2">
        <property type="nucleotide sequence ID" value="XM_675797.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VBW7"/>
    <dbReference type="STRING" id="227321.C8VBW7"/>
    <dbReference type="GeneID" id="2869584"/>
    <dbReference type="KEGG" id="ani:ANIA_10996"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN10996"/>
    <dbReference type="eggNOG" id="ENOG502QS9T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006921_1_1_1"/>
    <dbReference type="InParanoid" id="C8VBW7"/>
    <dbReference type="OMA" id="EHDGFHI"/>
    <dbReference type="OrthoDB" id="659at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="entry name" value="dinb family like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1580.10">
        <property type="entry name" value="paralog of FGE (formylglycine-generating enzyme)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024775">
        <property type="entry name" value="DinB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051128">
        <property type="entry name" value="EgtD_Methyltrsf_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005532">
        <property type="entry name" value="SUMF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042095">
        <property type="entry name" value="SUMF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43397">
        <property type="entry name" value="ERGOTHIONEINE BIOSYNTHESIS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43397:SF1">
        <property type="entry name" value="ERGOTHIONEINE BIOSYNTHESIS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12867">
        <property type="entry name" value="DinB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03781">
        <property type="entry name" value="FGE-sulfatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="DinB/YfiT-like putative metalloenzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DinB-like" evidence="5">
        <location>
            <begin position="37"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase-modifying factor enzyme-like" evidence="4">
        <location>
            <begin position="230"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase-modifying factor enzyme-like" evidence="4">
        <location>
            <begin position="411"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBF79758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="512" mass="57581" checksum="5DDBF7ADDA28F6E4" modified="2009-11-03" version="1">MGTDLHLLQPAALDLPLRPSQYAAGPIPSLKDFQAQWTAWDIVTKAMIPQEELLSKPIKLRNSLIFYLGHIPTFADIHLTRALGGKPTDPKSYQLIFERGIDPDVDDPEKCHSHSEIPDEWPSRSEILDYQDRVRNRIRSTLEIPGLSKNRTLGEALWIGFEHEAMHLETFLYMLIQSERVLPPPGIQAPDFKKIFLDARENAKPNEWFAIPEQTLSIGLDSSEDLMPTSTFGWDNEIPKRNVTVQPFEAQGRPVTNGEYARYLQKNQIHRWPASWIMTNQADGVANGSTATEDFLTDFSVRTVFGPVPLELAQDWPVIASYDELQQYASWMNCRLPTFEEAKSIYAHSARLKKTLTDGSADAASNGLKNGYHKPHLRNGTVKIAPSTAQPVLPPSASASSPPVFLDLTTCNVGFKNWHPMPVIQNGDKLAGHAELGGVWEWTSSPLEPHDGFKAMEIYPGYTSDFFDGKHNIILGGSWATHPRIVGRTTFVNWYQRNYPYAWAGARLVRDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>C8VD67</accession>
    <name>C8VD67_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SGNH hydrolase-type esterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ANIA_07158</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF78961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467891.1">
        <property type="nucleotide sequence ID" value="XM_050611921.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VD67"/>
    <dbReference type="GeneID" id="2870164"/>
    <dbReference type="KEGG" id="ani:ANIA_07158"/>
    <dbReference type="eggNOG" id="ENOG502SIJX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_601322_0_0_1"/>
    <dbReference type="InParanoid" id="C8VD67"/>
    <dbReference type="OMA" id="GTMHDND"/>
    <dbReference type="OrthoDB" id="6123at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd01833">
        <property type="entry name" value="XynB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051532">
        <property type="entry name" value="Ester_Hydrolysis_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30383:SF31">
        <property type="entry name" value="SGNH HYDROLASE-TYPE ESTERASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30383">
        <property type="entry name" value="THIOESTERASE 1/PROTEASE 1/LYSOPHOSPHOLIPASE L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002993587" description="SGNH hydrolase-type esterase domain-containing protein" evidence="2">
        <location>
            <begin position="36"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="SGNH hydrolase-type esterase" evidence="3">
        <location>
            <begin position="76"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="307"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBF78961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="366" mass="39376" checksum="ECEBFA693FBB30E4" modified="2009-11-03" version="1">MRAPITVSTTPGPAFLSRVSVGILLLLTFLTTASAASAIPALSTASLPEVTQQQHEDEYDLQPRSTKPFLLRVMPLGASITVGYMSSDENGYRKYLREQLRYAGWGVDMVGSLANGTMKDNQNEGHFGDTIDHIAEAAVNSTRLQPNVILIKYSNLLSLTSSSAYTCGSAGTNDCFQNIEINDADTRLDALITHLFASIPNTTIILSTLLPNEFASRAVRRVSQEYRNLVARRRSRGDRLVLAEMSYFITNDQLVDGTHPSDTGYKMMAAVWWSAIQTAEKEGKLSAPNIVTKSVLKDLVGINGTAQTEGKGLDDGPVEDPQLPEYNAPGQPGGSGGEGGAVALGSGLRVKLGLGMVGLWIVCEFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>C8VD76</accession>
    <name>C8VD76_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF3533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_07149</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF78977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_664753.2">
        <property type="nucleotide sequence ID" value="XM_659661.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VD76"/>
    <dbReference type="FunCoup" id="C8VD76">
        <property type="interactions" value="28"/>
    </dbReference>
    <dbReference type="GeneID" id="2870103"/>
    <dbReference type="KEGG" id="ani:ANIA_07149"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN7149"/>
    <dbReference type="eggNOG" id="ENOG502QUA0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020178_1_0_1"/>
    <dbReference type="InParanoid" id="C8VD76"/>
    <dbReference type="OMA" id="WTMVNLR"/>
    <dbReference type="OrthoDB" id="2140105at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022703">
        <property type="entry name" value="DUF3533"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053001">
        <property type="entry name" value="MNNG_permease-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34814">
        <property type="entry name" value="NITROSOGUANIDINE RESISTANCE PROTEIN SNG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34814:SF1">
        <property type="entry name" value="NITROSOGUANIDINE RESISTANCE PROTEIN SNG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12051">
        <property type="entry name" value="DUF3533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="272"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="317"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="352"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="409"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3533" evidence="2">
        <location>
            <begin position="38"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF78977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="438" mass="48666" checksum="71CEFED626283857" modified="2009-11-03" version="1">MADSEAGEKPSPKPAVGFWDPSLEPVRRQVFTKWARTVLLLCTFILCVLSLYWAVQFRSDDKLSNLKVWVVDFDNSQDGDALIGPAVTNLAAQLGTESQNLGYTIKSAADFEDPVAVVQAVYDEHCWAAIIVNPDATNLLRGAVNGNTSYNPSDAAQFVIISARDETTVSSYITPSFNAFELQLRAQFGPEWVRNLTQQSTNLSSVAPQAINPAVAFSTLDLRPFAPTAATPSVTIGLIYLIILSFFNFPFMMPVHALFMKGETTLKIPQWLIWRVCSSICTYFFLSLFYSFVSLAFQIPFSNDPAPDTVSANNPNAYGKGSFVVFWMLNWVGMGALGFPLENMSMILGFPYSSLFLIFWVITNVSSGFYALDVAPGFFKWGYAWPLHRIVNALRTILFGTHSKIGLDFGVLFAWIGVSLALFPVATFIMRWKMRRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>C8VFE0</accession>
    <name>C8VFE0_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DUF396 doamin protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ANIA_05788</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SVP26 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF81189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_663392.2">
        <property type="nucleotide sequence ID" value="XM_658300.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VFE0"/>
    <dbReference type="FunCoup" id="C8VFE0">
        <property type="interactions" value="241"/>
    </dbReference>
    <dbReference type="STRING" id="227321.C8VFE0"/>
    <dbReference type="GeneID" id="2872073"/>
    <dbReference type="KEGG" id="ani:ANIA_05788"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN5788"/>
    <dbReference type="eggNOG" id="KOG4136">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058268_0_0_1"/>
    <dbReference type="InParanoid" id="C8VFE0"/>
    <dbReference type="OMA" id="TMGTEPV"/>
    <dbReference type="OrthoDB" id="28257at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097020">
        <property type="term" value="F:COPII receptor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045053">
        <property type="term" value="P:protein retention in Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007277">
        <property type="entry name" value="Svp26/Tex261"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13144:SF0">
        <property type="entry name" value="PROTEIN TEX261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13144">
        <property type="entry name" value="TEX261 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04148">
        <property type="entry name" value="Erv26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBF81189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="218" mass="24274" checksum="5F4A7557C1AEFD34" modified="2009-11-03" version="1">MWILPLVGYLGVIIGFCFLTLAIARRLLSRLIYGIITIQILLLLVDKFPFSLSLLSIGSHIVYASNLRRFPIVKLSDPFFILSCFLVGLNHWLWFQHFSKPTTLQRSSTSWRQPYNVSPNDMPTFTEVASYFGLCVWLVPFALFVSLSAGENVLPTMGSEYATGKPVPTAGLSRGSLGADGKNKNKGMAKALVDGVREWVSENGELMGFWKGDRAKSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>C8VH63</accession>
    <name>C8VH63_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="11">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">ANIA_11163</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in the maturation of Asn-linked oligosaccharides. Progressively trims alpha-1,2-linked mannose residues from Man(9)GlcNAc(2) to produce Man(5)GlcNAc(2).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasmic vesicle lumen</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="11"/>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF82584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468354.1">
        <property type="nucleotide sequence ID" value="XM_050612430.1"/>
    </dbReference>
    <dbReference type="STRING" id="227321.C8VH63"/>
    <dbReference type="GeneID" id="74896820"/>
    <dbReference type="KEGG" id="ani:ANIA_11163"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN11163"/>
    <dbReference type="eggNOG" id="KOG2429">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003818_2_0_1"/>
    <dbReference type="InParanoid" id="C8VH63"/>
    <dbReference type="OMA" id="CTPLTRD"/>
    <dbReference type="OrthoDB" id="8118055at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060205">
        <property type="term" value="C:cytoplasmic vesicle lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044322">
        <property type="term" value="C:endoplasmic reticulum quality control compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904380">
        <property type="term" value="P:endoplasmic reticulum mannose trimming"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06661">
        <property type="entry name" value="GGCT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.10">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044674">
        <property type="entry name" value="EDEM1/2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013024">
        <property type="entry name" value="GGCT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036568">
        <property type="entry name" value="GGCT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45679:SF5">
        <property type="entry name" value="ER DEGRADATION-ENHANCING ALPHA-MANNOSIDASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45679">
        <property type="entry name" value="ER DEGRADATION-ENHANCING ALPHA-MANNOSIDASE-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110857">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="11 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="576"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="628"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="791"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="638"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="791"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="328"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9">
        <location>
            <position position="455"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="476"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="562"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CBF82584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="1339" mass="147959" checksum="AC17F93FB03FF82C" modified="2009-11-03" version="1">MNRGGNLSLEIRTETEQMFYHGFENYLEHAFPEDELRPLSCEPLVRDRQNPGHAELNDVLGNYSLTLIDSLSTLAILASSPDDGPKAWQYFQDGIKDFVRLYGDGSDSVTGQGERSRGFDIDSKVQVFETVIRGLGGLLSSHLFAVGDLPITRYSPPEKEAAYAKAWDKTSFAADSRGIAWDNGFVYDGQLLRLAVDLANRILPAFYTHTGLPYPRVNLRHGVHQQPFYANSPLNADTVRVCDDKNGNVCDASSAEVTETCSAGAGSLVLEFTLLSRLTGDGRYEELAKRAFWAVWYRRSDIGLIGAGIDAESGKWVAPFTGIGAGVDSFFEYAFKSYVLLSSGERPEHNRSSPWHALDDYFLPLSEYEHSPEAFLQVWEESHSSIKRHLYRGEGYQHPHLIQGDIFTGATRAFWIDSLSAFYPGLLSLAGDLDEAIGIHLLTTAVWNRFSGLPERWNVATGNVEGNLGWYGGRPEFIESTYYLYQATKDPWYLHVGEMVLRDLKRRCWTRCGWAGLQDVRNGELSDRMESFFLGETAKYMFLLYYPEHPLNHLDQPFVFTTEAHPLLIPKSIYSTQRSSRRKKKEHGEKHSAAPTCQAAPLPPAFGLSSTAARPDVFHAANLARLDLMPSRGPPEGPLEKPAKDRPGVTIADLTSPTNYTFFPWTLPPELVPFNATSSLMAIRPTLDISFPAVPGMAHGPGSLERVQDGILVKSIGGLRMSMIKDALSYSAEGSEFRVQMINGVPLGKDEKVYLLWEITFDVLDPGDPNFTRVRDPAMIDLIIDIIPENLGRRNDSDDGREPAASGTGAHQRIINANAPVDDDKAAAPVDASTSSMRNVLSSLVNSVASMLQDEVNQIYTPAPSVSKPRPTRLPIPAAVSTGLGSGPLPDVDDSPLVSINGGTSQVRLPWSDIYMADDLCNQRILRSVAQTYQVLVIKRRGCTFSQKLRNIAAHPPSKNALKLVIVVSYDEEEHIDGQNLGLGYAARLAEPYLVRPQLDERQVTAGGIPRRHLLSMVLVGGGDETVHPNHAGSASPRSINIGTKDHTLEFAIVGLHSLFSTLSIFRPFVPLSISSGTHPSSRISFNWHIKNQDGLIPQTIPTTATTAINPSSAQHTPPDTAPKNAPKHLYFAYGSNLSPTQMRMRCVHNPTLSGHPVALAALDSWRWLICQPGYANVVPPAGLRVGPQITEGDNVPESISKSIPRGGVYGVLYEMSAEDETVLDRYEGVHCLAGESTEEQKVPLEIRPKEQEAGDYNKWYVDARVVKWLDEGYRERKGLQGVGGKVRVLVYVDELRVKVGKPKEEYIPRMNRAIGEAVQLGFPRDWAEEVMRPSIPLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>C8VHC2</accession>
    <name>C8VHC2_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent DNA helicase CHL1</fullName>
            <ecNumber evidence="18">5.6.2.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">ATP-dependent DNA helicase chl1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Chromosome loss protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19 20">DNA 5'-3' helicase CHL1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">ANIA_10414</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="26" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="26">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="21">ATP-dependent DNA helicase important for chromosome transmission and normal cell cycle progression in G(2)/M. May have a role in changing DNA topology to allow the loading of proteins involved in maintaining sister chromatid cohesion in the vicinity of the centromeres. Has a specific role in chromosome segregation during meiosis II.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DEAD box helicase family. DEAH subfamily. DDX11/CHL1 sub-subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="18"/>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF82692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_661048.2">
        <property type="nucleotide sequence ID" value="XM_655956.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VHC2"/>
    <dbReference type="FunCoup" id="C8VHC2">
        <property type="interactions" value="967"/>
    </dbReference>
    <dbReference type="STRING" id="227321.C8VHC2"/>
    <dbReference type="GeneID" id="2873899"/>
    <dbReference type="KEGG" id="ani:ANIA_10414"/>
    <dbReference type="eggNOG" id="KOG1133">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006515_2_0_1"/>
    <dbReference type="InParanoid" id="C8VHC2"/>
    <dbReference type="OMA" id="QTHQFRD"/>
    <dbReference type="OrthoDB" id="267079at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045005">
        <property type="term" value="P:DNA-templated DNA replication maintenance of fidelity"/>
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        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0034085">
        <property type="term" value="P:establishment of sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0031571">
        <property type="term" value="P:mitotic G1 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
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        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="CDD" id="cd18788">
        <property type="entry name" value="SF2_C_XPD"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ATP-dependent DNA helicase chl1"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="3.40.50.300:FF:002774">
        <property type="entry name" value="ATP-dependent DNA helicase chl1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="ATP-dep_Helicase_C"/>
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    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
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    <dbReference type="InterPro" id="IPR014013">
        <property type="entry name" value="Helic_SF1/SF2_ATP-bd_DinG/Rad3"/>
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    <dbReference type="InterPro" id="IPR006554">
        <property type="entry name" value="Helicase-like_DEXD_c2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010614">
        <property type="entry name" value="RAD3-like_helicase_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013020">
        <property type="entry name" value="Rad3/Chl1-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00604">
        <property type="entry name" value="rad3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472:SF41">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE DDX11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06733">
        <property type="entry name" value="DEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13307">
        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00488">
        <property type="entry name" value="DEXDc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00491">
        <property type="entry name" value="HELICc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51193">
        <property type="entry name" value="HELICASE_ATP_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 25" id="KW-0347">Helicase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="14" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="24">
        <location>
            <begin position="13"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="111"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="23">
        <location>
            <begin position="135"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="23">
        <location>
            <begin position="159"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008435"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
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            <dbReference type="ARBA" id="ARBA00022806"/>
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            <dbReference type="ARBA" id="ARBA00029709"/>
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            <dbReference type="ARBA" id="ARBA00044998"/>
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    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00045008"/>
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    </evidence>
    <evidence type="ECO:0000256" key="21">
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    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00048954"/>
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    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS51193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="CBF82692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="841" mass="94763" checksum="2E76BBBE4C25A3C0" modified="2009-11-03" version="1">MNKDTLSSMEPSKPQTFNHPYTPYDIQVRFMQSLYECLEEGKVAIFESPTGSGPRLQIIELSCTDWTRNRDDDEPEWMVEFAKREASRAVTEKRIEFESRLARIKREEEQQRAALESSEGSRKRQRVSVVSRDQDTEDDDQFALDDYDSENDEPSSIPRGSATATGLSSSTLELLERLRKYGSKIKPEEDDENDIKIFYCSRTHSQLMQFASELRRVTMPSTLPESLRQGLTDEEEQGERIKHISLGSRKNLCINSRVAALGNPTAINERCLELQQPNTPAPLRCSYLPTEEDEAKTLSFRDHALATVKDIEDLGKLGKKLGLCPYYASRGVVSHSERSARDALNLSIKGHVVIIDEAHNLMDAISNIHSVTVTLSQLRTSIFQLTTYARKFKTRLKGKNRNYIAQVIRLISSIADHLQSLIDNKQASEGSVLSSDLMAGKGADQINPYKLCRYLNESKLARKVDGYIDFSQSKANAQAEPKSTIPVLFHIQSFLLPLMNLSSEGRLFFTKTPGDIQLHYMLLDPTNHFREIVEDARAVILAGGTMSPMSDYLNHLFSYVPKDRLNTFSYGHVIPSENLTAHTLARGVTGCEFDFTYAGRDAEKMILDLGRTFTQLCRAIPDGIVAFFPSYEYLSRVLNIWKNAVVRENKQTLYETVEKEKQILYESRETELTTDDLLNNYANTINKGRGALLLSVVGGKLSEGINFSDKLGRGVLIVGLPFPNIRSPVWQAKIKYIEQKAYRNVGSGSEESRRLSAKAAGRDFYENACMRAVNQCIGRAIRHRNDYAAIVLIDKRYGKTSIEAKLPGWIKQSLVKDSALLPAATTLDGLACFFRSKNHCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>C8VJ05</accession>
    <name>C8VJ05_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Replication factor C subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ANIA_02969</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the activator 1 small subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF83646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468484.1">
        <property type="nucleotide sequence ID" value="XM_050612575.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VJ05"/>
    <dbReference type="FunCoup" id="C8VJ05">
        <property type="interactions" value="629"/>
    </dbReference>
    <dbReference type="STRING" id="227321.C8VJ05"/>
    <dbReference type="GeneID" id="2873711"/>
    <dbReference type="KEGG" id="ani:ANIA_02969"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN2969"/>
    <dbReference type="eggNOG" id="KOG0989">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042324_1_0_1"/>
    <dbReference type="InParanoid" id="C8VJ05"/>
    <dbReference type="OMA" id="GCQSGSF"/>
    <dbReference type="OrthoDB" id="4199794at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031390">
        <property type="term" value="C:Ctf18 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031391">
        <property type="term" value="C:Elg1 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031389">
        <property type="term" value="C:Rad17 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902983">
        <property type="term" value="P:DNA strand elongation involved in mitotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
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        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="P:sister chromatid cohesion"/>
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        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0070914">
        <property type="term" value="P:UV-damage excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18140">
        <property type="entry name" value="HLD_clamp_RFC"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="1.20.272.10:FF:000011">
        <property type="entry name" value="Replication factor C subunit 2"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="replication factor C subunit 4"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050238">
        <property type="entry name" value="DNA_Rep/Repair_Clamp_Loader"/>
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    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013748">
        <property type="entry name" value="Rep_factorC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047854">
        <property type="entry name" value="RFC_lid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669">
        <property type="entry name" value="REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669:SF20">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF21960">
        <property type="entry name" value="RCF1-5-like_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08542">
        <property type="entry name" value="Rep_fac_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="9">
        <location>
            <begin position="66"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005378"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBF83646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="387" mass="42736" checksum="B5B72350912C7762" modified="2009-11-03" version="1">MAANFFSNKARAAAAFSSSKQKPTEGKEEQSRLQPWVEKYRPKTLDDVAAQDHTTKVLQRTLQASNLPHMLFYGPPGTGKTSTILALAKSLFGPALYRSRILELNASDERGIGIVREKVKGFARVQLSHPTGLDAEYFEKYPCPPFKIIILDEADSMTQDAQSALRRTMEQYSRITRFCLVCNYVTRIIEPLASRCSKFRFKPLDNSAAGDRLAQIAQLEKLSLENGVVDKLISCSDGDLRRAITYLQSAARLVGAAKAAKDGDEDEEMKDQGSDMITVSTIEEIAGVVPESVLDGLIQSLQPKRMGSPYEAVSKVVTEIVADGWSATQILLQLYRRMVYNDAIPDIQKNKIVLVFSEMDKRLVDGADEHLSILDVALKISGILGGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>C8VJ72</accession>
    <name>C8VJ72_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Basic leucine zipper (bZIP) transcription factor atfB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">ANIA_02911</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bZIP family. ATF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF83765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468508.1">
        <property type="nucleotide sequence ID" value="XM_050612600.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VJ72"/>
    <dbReference type="FunCoup" id="C8VJ72">
        <property type="interactions" value="620"/>
    </dbReference>
    <dbReference type="STRING" id="227321.C8VJ72"/>
    <dbReference type="GeneID" id="2873952"/>
    <dbReference type="KEGG" id="ani:ANIA_02911"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN2911"/>
    <dbReference type="eggNOG" id="KOG1414">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034316_1_0_1"/>
    <dbReference type="InParanoid" id="C8VJ72"/>
    <dbReference type="OMA" id="HGAFMSQ"/>
    <dbReference type="OrthoDB" id="295274at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd14687">
        <property type="entry name" value="bZIP_ATF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000053">
        <property type="entry name" value="BZIP transcription factor AtfA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051027">
        <property type="entry name" value="bZIP_transcription_factors"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021755">
        <property type="entry name" value="TF_Aft1_HRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021756">
        <property type="entry name" value="TF_Aft1_HRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020956">
        <property type="entry name" value="TF_Aft1_OSM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19304">
        <property type="entry name" value="CYCLIC-AMP RESPONSE ELEMENT BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11786">
        <property type="entry name" value="Aft1_HRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11787">
        <property type="entry name" value="Aft1_HRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11785">
        <property type="entry name" value="Aft1_OSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0346">Stress response</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="11">
        <location>
            <begin position="402"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="299"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="427"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="25"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="299"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="376"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="392"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00068999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CBF83765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="485" mass="51076" checksum="32CA4AF15613CB40" modified="2009-11-03" version="1">MSAAVASAVSTTLPSNPTAHSSPMDAKKNSVKMDNEASSETKEQKTDGEPQTSLAPPSRPNPSAATDTPDYFNSVHNPFALEPNPFEQSFGGGSGETPGKSILPPVASITSPALPGTSSAGGAYNWSNSLRSGPLSPAMLAGPAGGSDYFDSIGRGFPTPNESSLRTGLTPGGGGSMFPAPSPNSQALLNQLQNGGATPSTIEFHRTALNVKKNGIAPTSNPTGEGDQVPQNITTTMDIKPAQPATVDFGPHDAADAANGLFMLAKGGQSTANQFAAVSNQTAIPPQTLQTSEILQDQNAARRQSVNVNGVANTREPSGDGSEQSEQAKPARGRGKRNTSTKASSTGNRRKTDDSTQGSNKRTKLNNGAASTESPSEGESEEEEQQPAQKKKAGDTKKMTDEEKRKNFLERNRVAALKCRQRKKQWLANLQAKVELFTSENDALTTTVTQLREEIVNLKTLLLAHKDCPVSQAQGLIWNPNPPYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>C8VJ88</accession>
    <name>C8VJ88_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LipA and NB-ARC domain protein (AFU_orthologue AFUA_3G11500)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_02895</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF83794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468510.1">
        <property type="nucleotide sequence ID" value="XM_050612602.1"/>
    </dbReference>
    <dbReference type="GeneID" id="2873963"/>
    <dbReference type="KEGG" id="ani:ANIA_02895"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN2895"/>
    <dbReference type="eggNOG" id="KOG2029">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001668_1_0_1"/>
    <dbReference type="InParanoid" id="C8VJ88"/>
    <dbReference type="OMA" id="QSWATEP"/>
    <dbReference type="OrthoDB" id="5086500at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48187">
        <property type="entry name" value="LD21810P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48187:SF2">
        <property type="entry name" value="LD21810P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NB-ARC" evidence="2">
        <location>
            <begin position="390"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="868"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="942"/>
            <end position="1144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1243"/>
            <end position="1311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1404"/>
            <end position="1478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="885"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="971"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1013"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1083"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1277"/>
            <end position="1289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1404"/>
            <end position="1420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF83794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="1478" mass="163804" checksum="29A628011EA75B7B" modified="2009-11-03" version="1">MDIASRIRQYGLNVVHEAPDALVDIVFVHGLNGHPHRTWTSSKTGVFWPVDLLPDVLSSCRVRILSYGYNANVTSFTDGASKDRILNHSETLAASLAANRTIKDCTERPIIFVCHSLGGLVVKRALIYSRSLTNEKVEHLRSIYVSTYGILFLGTPHNGSEVAKWGLLLQNICSAVLPRKFLDSSPQLIKALKTNNETLQNINSLFADMMPRYRICFFHETLPMDVKGTRELIVDESSAAPHADGVERMGIEADHSHMCKFDDETAPGYEAVAVALLRFAREAPATIRERWNEEERTRMIIRTQKAREIFGDVSPSGGSERLGDRSLGGNRPSDAPVNPHVLYLPSNEKVSTSKSLENSTDLSMSLSVQRGPLWVVPPGFHRNATFFGMEKELEILHTRLFKAKKRADHLMAVLICGVPGSGKSHLARQYVWNHRDDYPGGIFWVDAKSRQSTFKCFWDIAQAATLTEGEEFQSPDTKSPSKYVEAVRHWLQSRQEWLLVFDGVSFAHDDDINNFKQFLPFKERCGIIYTSVDKTLRKKQRLYEPYCLLVAPLQVEDACKLLFKDLGIKRPTKEQIRKATEVVTHYECLPLAIHAISHRLSATDKPIEKYHINSHFTDEKLAEPFLSIMHDLFRGGHFQALNLINLLSFLGHQVPVGLVLLGKSFLEAWNIEVFTSSRHGEPGDLDTTLGVLIRYGLIERTSDKYPLLQTPLSPISERYMVDPKAVVPEMSESQTESSQEGFFAQYQSSGVSDVVKIHSVVQGFCRDELKIMDKELRANGSRPGQNTGYYDSWLVVATHVFCTSFENAKCRMDRVDDCGSVKDYREYETHASQLMKNFPKKTAHGIVSDSLKQLKEALKTIRSEIDRISPSSSQDSVRKHRSVFDRSSSSSSFPDSTASDGPSRQLTLDFSDVAPVRSESPQDALAIPQQVNLGPIIPHIFRNSSGRGKDEINDDGLLRDGYLTDDESTRARSPARSQASQSTERPKPSPSSPHQQTDDEGWHVVENPSRTKPAAKLKQRQGQKSKRRPKFPRVGNSEPAAPVPAAPVLERTPAWRSLSGGALSERTPRRTASEALSAVKKASPTQSSEHSVPRVSTNSSKENAPTYAFVASKLASAKEPISASKDRRSSSSPGGKQRPVFSIIQSRGSEESLSSYSVSTDYKQDPLSFSTYSEPDHGLLQQLNALDLSSQYPINPNTGRRIVPADLSLSTPTLGLPYESNIEIKVPRRRFQGSAIPAFSSKSATNLSSIPGPHPSAIMPGASPPSSDPASELMSRGPSSRSHQSWTTEPTSRRYSSRISPPPTLNPASVSGSAGQYHFISHATPQALAGPAAWVPDPSMQTVQRPYSNLPSDNSYAAVVQRQYIPVPTPNNDPHAVMPPPPPPTLHFGTHRVDLQARLRSSPQYQYDIQQPQPQSQSPYHVYNHENHSGPLFPLPTHESSASGSYAKEFSIGSANRARARSGSTPSHPYPPGLGLDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>C8VKM7</accession>
    <name>C8VKM7_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ANIA_11351</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF87188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VKM7"/>
    <dbReference type="HOGENOM" id="CLU_3429974_0_0_1"/>
    <dbReference type="InParanoid" id="C8VKM7"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF87188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="19" mass="2405" checksum="56AB25EAC59C3B1B" modified="2009-11-03" version="1">MHKCHKYVVQYHLFSLEIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>C8VLS7</accession>
    <name>C8VLS7_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">ABC multidrug transporter (Eurofung)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">ANIA_08892</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF84719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468609.1">
        <property type="nucleotide sequence ID" value="XM_050612725.1"/>
    </dbReference>
    <dbReference type="GeneID" id="2868208"/>
    <dbReference type="KEGG" id="ani:ANIA_08892"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN8892"/>
    <dbReference type="eggNOG" id="KOG0065">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_35_0_1"/>
    <dbReference type="InParanoid" id="C8VLS7"/>
    <dbReference type="OMA" id="CLTAQFR"/>
    <dbReference type="OrthoDB" id="245989at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03233">
        <property type="entry name" value="ABCG_PDR_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03232">
        <property type="entry name" value="ABCG_PDR_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001569">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000054">
        <property type="entry name" value="ABC multidrug transporter atrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034001">
        <property type="entry name" value="ABCG_PDR_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034003">
        <property type="entry name" value="ABCG_PDR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010929">
        <property type="entry name" value="PDR_CDR_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06422">
        <property type="entry name" value="PDR_CDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="555"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="594"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="627"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1185"/>
            <end position="1206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1221"/>
            <end position="1251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1258"/>
            <end position="1276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1282"/>
            <end position="1304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1316"/>
            <end position="1335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1413"/>
            <end position="1437"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="111"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="824"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="787"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="795"/>
            <end position="807"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CBF84719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="1448" mass="162058" checksum="CA28C5870194C2C5" modified="2009-11-03" version="1">MPARLHSRPQGNSTLASSQEAGDHADRPSSPQVHLTYEDEDAIAEIHRTLTKKDHDYSEPHLSFDKFLEEELRAGRKKPNLGVCFQSLSTWGTGGEHVNVKTLGTALWRTLIFQDVYEWTIKPWLAKPEPESGRQLIRDFTGVVRSGEIMLVLGRPGSGCSTFLRTIAGYHSSFLGVTGSIAYSGLSLEDVRKHYRGQVAYVPEDDVHFPTLSVRQTLEFALQSKTPKRYHDRIPRYLEIYGRVFGMSHTMDTLVGNEYIRGVSGGERKRISIIESLATDSSVMCWDNSTRGLDASSALDYARSLRIMTDTCGKATLMTLYQASDAIYDLVDKVLLIDEGRMLYQGPAHEAKAYFHDLGYECGPMQTVSDFLTSITIPERRKFREGWEQRAPKGPIELEQAFRKSAAFMNVQKEVRSYDSQGFGGRSRAESHSDTDYESLEDVKEALQTDKSRFVSSKSPYTISLFRQVVLCAKRQIWQIRGHMSPLYIKLISSVIYGLLVGSMFYDQPQTTDGMYSRGGVIFYSSILLAWLQMSELEEAMQGRDILSRQKKFAFVRPSAVCLARVVADIFIAALLTFLYLVVVYFLSGLKSDAGAFFIDFLFIYMCTISLTAQFRLFAAASSNFEVALRYTGFLVLLCIVFGGYVLSVDKMMADVPWVGWIAYITPALYTYEAMMAAEFHNTNFTCSPASVVPAGPVYTDIAYQTCAYAGSQIGSTIVNGDDYLAVKYGFYFSHVWRNFGILCLFTVASVAATCLLSEIMEWEPDSAGPVQYKKSRKQLRKIANISDEEERPVQVNQTSPSASDTDGPSVGALTATKSTFTWDNLELFVRVGKENRKLLDGVSGYCKPGTLTALVGASGAGKSTLLTALTQRQSSGDLTGTMYVDGRPIDSSFKSRIGYCEQMDIHDESSTIREAFEFSALLRQDSTVPDQEKLAYARTVLETLDLVELQNAIIGSLDIEKKKRVTIGVELCARPELLLFLDEPTSGLDSQAASSICALLRRLADQGLAILCTIHQANQEQFEMFDRVLALSPGGKTYYFGEVGEAGHSIFDYFAKYGQKPENITNAADYIIEVVVGGMKNTASTVDWAAVWNQSVEAQQVQQDLERFRNMKQESLPSLDMQSQAMPAISRQIFLLTQRTSRQFWRSPEYPYSRLYASFLHALINCLTYLQIGNSTTDLQSKAFSCFLVLMLVPEFINAISARFIMNRDLWKAREGPSGAYGWVAFCTAQIISEIPYAIISAVVFFVLYYFSVGLPLGFAAGYSFLMFFLFFLFATSWGQWIAALSADSVVAATLMPFFIIMCETMNGILQPHKYMPAFWAYTMYYVTPFTYWIGGVLTSVLRGVPVICDENELTVFQSPPNITCSEYAGSWLAEKGVGYLSNPDGSGECGYCEYSYGDDYLSTIGLDSSKIWPYFGIFVAFVVSNYLMVYLLVYIRSVMKPFRRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>C8VLW2</accession>
    <name>C8VLW2_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ANIA_10202</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF84786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468624.1">
        <property type="nucleotide sequence ID" value="XM_050612743.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VLW2"/>
    <dbReference type="STRING" id="227321.C8VLW2"/>
    <dbReference type="GeneID" id="74896267"/>
    <dbReference type="KEGG" id="ani:ANIA_10202"/>
    <dbReference type="eggNOG" id="KOG0101">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005965_3_1_1"/>
    <dbReference type="InParanoid" id="C8VLW2"/>
    <dbReference type="OMA" id="NIPPMQA"/>
    <dbReference type="OrthoDB" id="2401965at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000172">
        <property type="entry name" value="Heat shock 70 kDa protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000028">
        <property type="entry name" value="heat shock 70 kDa protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000014">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000004">
        <property type="entry name" value="Heat shock protein SSB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0346">Stress response</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBF84786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="390" mass="42750" checksum="BAA62DA7D33BF18F" modified="2009-11-03" version="1">MQAGDTHLGGQDFDTNLLEHFKKEFQKKTGKDLSGDSRALRRLRTACERAKRTLSNATQTSVEIDSLFDGEDFNTSITRARFEDLNAKSFSGTLEPVQQVLKDSGLAKNQVDEIVLVGGSTRIPRIQKLLSDFFDGKKLEKSINPDEAVAYGAAVQAGILSGKATSAETQDLLLLDVVPLSLGVAMEGNIFAPVVPRGQTVPTIKKRTFTTVVDNQTTVQFPVYQGERTNCADNTSLGEFTLAPIPPMRAGEAALECVFEVDVNGILKVTATEKSSGRSANITISNAVGKLSTTEIEQMIDDAAKFKTSDEAFTKRFESRQQLESYISRVEEIISDPTMSMKLKRGNREKIESALSDAMAQLEIEDSTPEDLKKKELALKRLITKAMATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>C8VP86</accession>
    <name>C8VP86_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ANIA_11342</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF86912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468901.1">
        <property type="nucleotide sequence ID" value="XM_050613059.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VP86"/>
    <dbReference type="GeneID" id="74896943"/>
    <dbReference type="KEGG" id="ani:ANIA_11342"/>
    <dbReference type="HOGENOM" id="CLU_2454731_0_0_1"/>
    <dbReference type="InParanoid" id="C8VP86"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF86912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="89" mass="9826" checksum="CA822864D331D5BC" modified="2009-11-03" version="1">MRISQCGSPAAAAAFSNSSRYGCFSVSSVPGWERLAPLSRPDNSGYTPVQVPTWHELTHPDIDTPRIPYRSMRATTSPSYHVLRTMEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>C8VPX6</accession>
    <name>C8VPX6_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zona occludens toxin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ANIA_11203</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF87224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_682507.2">
        <property type="nucleotide sequence ID" value="XM_677415.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VPX6"/>
    <dbReference type="GeneID" id="2867906"/>
    <dbReference type="KEGG" id="ani:ANIA_11203"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN11203"/>
    <dbReference type="eggNOG" id="ENOG502QQSW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015256_5_2_1"/>
    <dbReference type="InParanoid" id="C8VPX6"/>
    <dbReference type="OMA" id="VHRCTSP"/>
    <dbReference type="OrthoDB" id="2316594at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053236">
        <property type="entry name" value="Cornifin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13884:SF16">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13884">
        <property type="entry name" value="DUF853 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF87224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="418" mass="46016" checksum="C049A306215E6F20" modified="2009-11-03" version="1">MDSSLCNNADDHSRTAYQLSLLKLGFSGDEAKDVSLAPVFTGPVLYTQPNLVPSQYGLLAGVLELPVVFHYDTFIGDQGGSPCEAAFLATSPKCPSEGSLCPQQISEIFRFKIRVHPLQINQQDLNTKRMLDLMTAGQGSSSGPLYLHTVQRVLREMRLLQQVSGGRFDYQDFKKRIFDSDLLPSQQQPLRQRLDILESFMPSQQIIASTSKKGKKAVNDAGTSWSPKVFLEQDTNVGRVVALDEAHKYMKDSAEAQIFTETLLSSVRLQRHLATRIVISTQEPTISADLLSLCSVTIVHRFSSPAWLRALQHHVAAAALGVESNNKTFSEKEESQGQAHMSSKLSFLDRIVRLRVGEALLFAPSAVFRVTFEGSGTPAVSKLGGGYMKIKTGCGISSWVAANRKVCLRQTVGRKPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C8VQ09</accession>
    <name>C8VQ09_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Autophagy-related protein 27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">ANIA_00861</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="23" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="23">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Golgi apparatus membrane</location>
            <topology evidence="4">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Preautophagosomal structure membrane</location>
            <topology evidence="3">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ATG27 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF88640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050469115.1">
        <property type="nucleotide sequence ID" value="XM_050613287.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VQ09"/>
    <dbReference type="GeneID" id="2876635"/>
    <dbReference type="KEGG" id="ani:ANIA_00861"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN0861"/>
    <dbReference type="eggNOG" id="ENOG502QVJJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047751_0_0_1"/>
    <dbReference type="InParanoid" id="C8VQ09"/>
    <dbReference type="OMA" id="GSSHWGF"/>
    <dbReference type="OrthoDB" id="29460at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.130.10:FF:000035">
        <property type="entry name" value="Autophagy protein Atg27, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.130.10">
        <property type="entry name" value="Mannose-6-phosphate receptor binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018939">
        <property type="entry name" value="Autophagy-rel_prot_27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009011">
        <property type="entry name" value="Man6P_isomerase_rcpt-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044865">
        <property type="entry name" value="MRH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15071:SF13">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15071">
        <property type="entry name" value="MANNOSE-6-PHOSPHATE RECEPTOR FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09451">
        <property type="entry name" value="ATG27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51914">
        <property type="entry name" value="MRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0072">Autophagy</keyword>
    <keyword evidence="17" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="15 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 20" id="KW-0732">Signal</keyword>
    <keyword evidence="8 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002991654" description="Autophagy-related protein 27" evidence="20">
        <location>
            <begin position="24"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="261"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="MRH" evidence="21">
        <location>
            <begin position="24"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="187"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="18">
        <location>
            <begin position="190"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="204"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="CBF88640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="332" mass="36546" checksum="441D03FF32161A22" modified="2009-11-03" version="1">MRIFSSPLISAVSLLPCLSFAVSFDCSSIHVDNYNYNLKALGGVHEIYHAEQVGDLIVNTTYVLNLCNTLKGASIRGNLKCGTSKNICGFNYTYGADGATENDFAFPIVGLEPMGQGAKDAEITRLKKEDTEKEGLRVKLSGGGEYPEPGSKKKKKAGAVIEFECDPGRSGLEGLVKEDTKRLLRAREEGLDEGEGDGEGDGNGEDKEPFYDGSDPDRSLQYKSFGKADDETYILSLSWKTRYACDHYTEDRGSSSGHGGFFTWLIVIFFLCAAAYLIFGSWLNYNRYGARGWDLLPHGDTLRDIPYLFQDWLRRVVNTFQGAGSRGGYSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>C8VS59</accession>
    <name>C8VS59_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_11300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF87720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050469001.1">
        <property type="nucleotide sequence ID" value="XM_050613165.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VS59"/>
    <dbReference type="GeneID" id="74896904"/>
    <dbReference type="KEGG" id="ani:ANIA_11300"/>
    <dbReference type="HOGENOM" id="CLU_2399674_0_0_1"/>
    <dbReference type="InParanoid" id="C8VS59"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF87720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="93" mass="10240" checksum="CF44920DE80927DD" modified="2009-11-03" version="1">MPANFELEDGSATRLKRDALAGYQYRCRQKRSLSASTLGQPINIRSHGAANIASAETNPKNQSRLVRRENPERASPKQGNPGCQNQGFPRLCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>C8VT05</accession>
    <name>C8VT05_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Nuclear mRNA splicing factor-associated protein, putative (AFU_orthologue AFUA_1G10920)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ANIA_01188</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HTATSF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF87970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050469027.1">
        <property type="nucleotide sequence ID" value="XM_050613194.1"/>
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    <dbReference type="AlphaFoldDB" id="C8VT05"/>
    <dbReference type="FunCoup" id="C8VT05">
        <property type="interactions" value="68"/>
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    <dbReference type="STRING" id="227321.C8VT05"/>
    <dbReference type="GeneID" id="2876965"/>
    <dbReference type="KEGG" id="ani:ANIA_01188"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN1188"/>
    <dbReference type="eggNOG" id="KOG1548">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026945_0_2_1"/>
    <dbReference type="InParanoid" id="C8VT05"/>
    <dbReference type="OMA" id="DTDFRFG"/>
    <dbReference type="OrthoDB" id="10258585at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12281">
        <property type="entry name" value="RRM1_TatSF1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12285">
        <property type="entry name" value="RRM3_RBM39_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000105">
        <property type="entry name" value="HIV Tat-specific factor 1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000722">
        <property type="entry name" value="Nuclear mRNA splicing factor-associated protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034393">
        <property type="entry name" value="TatSF1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034392">
        <property type="entry name" value="TatSF1-like_RRM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15608:SF0">
        <property type="entry name" value="HIV TAT-SPECIFIC FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15608">
        <property type="entry name" value="SPLICING FACTOR U2AF-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="118"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="82"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="362"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="101"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="385"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBF87970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="396" mass="44762" checksum="BF2B4C3BC261C80E" modified="2009-11-03" version="1">MALQDPKHDPTATGSPPAISNFPQDPSDFDSDPRVSFSKLDNKFILETDDGQEYSYDTILKRWIPTIDDDLLRQQQEAYKVEGVDEDEQAGAQRLKKKRKQGSEEGDAQKPKKQRVNTAVFVTSIPLDAEFDEIRDIFSRCGVIAEEIDSGRPRIKMYTDDEGKFKGEALVVYFRPESVNLAIQMLDDSDFRLGVPGPQGPMRVQPADFSFKSQQEAPTKTSMRDKKKIIKRTQKLNNKLADWDDDEPAALVDTNSKFEKIVILKHMFTLQELEEDPAAILDIKEDIREECSKLGEVTNVVLYDKEEAGVVSVRFSNPESARACVKLMNGRFFGGTAVEAYISDGSERFRKSNEKRAALEDLAEKGLDAEDDDENQRLDEFGTWLESSHTVENTAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>C8VUF8</accession>
    <name>C8VUF8_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_00959</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF88440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_658563.2">
        <property type="nucleotide sequence ID" value="XM_653471.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VUF8"/>
    <dbReference type="GeneID" id="2876735"/>
    <dbReference type="KEGG" id="ani:ANIA_00959"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN0959"/>
    <dbReference type="HOGENOM" id="CLU_119136_0_0_1"/>
    <dbReference type="InParanoid" id="C8VUF8"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF88440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="151" mass="16672" checksum="7B6737CAF17BCF21" modified="2009-11-03" version="1">MPQRRHRIDFSLLRRRQNFSSASSSDLSPGIPVLQSPMSFHAMASPEVPEATLKRNKLDRAPVKPSMFFEDMDEEDDGPVTKSTAHDHKDVPAPRTAQKVISGESPPKTQFFEDSFSSGVSFVPPVARIGQDSLVVIEVLVNVSVSRPSQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-12-14" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>G5EB28</accession>
    <accession>C8V4Q0</accession>
    <name>G5EB28_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ANIA_04163</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat G protein beta family. Ribosomal protein RACK1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF74576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_661767.1">
        <property type="nucleotide sequence ID" value="XM_656675.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G5EB28"/>
    <dbReference type="FunCoup" id="G5EB28">
        <property type="interactions" value="1321"/>
    </dbReference>
    <dbReference type="STRING" id="227321.G5EB28"/>
    <dbReference type="GeneID" id="2873584"/>
    <dbReference type="KEGG" id="ani:ANIA_04163"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN4163"/>
    <dbReference type="eggNOG" id="KOG0279">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_57_7_1"/>
    <dbReference type="InParanoid" id="G5EB28"/>
    <dbReference type="OMA" id="NCKLKIN"/>
    <dbReference type="OrthoDB" id="7875889at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001965">
        <property type="term" value="F:G-protein alpha-subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005092">
        <property type="term" value="F:GDP-dissociation inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005080">
        <property type="term" value="F:protein kinase C binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043495">
        <property type="term" value="F:protein-membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030546">
        <property type="term" value="F:signaling receptor activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045182">
        <property type="term" value="F:translation regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097308">
        <property type="term" value="P:cellular response to farnesol"/>
        <property type="evidence" value="ECO:0000270"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070791">
        <property type="term" value="P:cleistothecium development"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140469">
        <property type="term" value="P:GCN2-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990145">
        <property type="term" value="P:maintenance of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061157">
        <property type="term" value="P:mRNA destabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903138">
        <property type="term" value="P:negative regulation of cell integrity MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902660">
        <property type="term" value="P:negative regulation of glucose mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903753">
        <property type="term" value="P:negative regulation of p38MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001125">
        <property type="term" value="P:negative regulation of translational frameshifting"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070651">
        <property type="term" value="P:nonfunctional rRNA decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010508">
        <property type="term" value="P:positive regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070798">
        <property type="term" value="P:positive regulation of cleistothecium development"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031139">
        <property type="term" value="P:positive regulation of conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006521">
        <property type="term" value="P:regulation of amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000765">
        <property type="term" value="P:regulation of cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141014">
        <property type="term" value="P:ribosome hibernation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990116">
        <property type="term" value="P:ribosome-associated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000039">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit beta-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045223">
        <property type="entry name" value="RACK1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19868">
        <property type="entry name" value="RECEPTOR FOR ACTIVATED PROTEIN KINASE C RACK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="11"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="59"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="101"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="144"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="188"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="288"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBF74576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="316" mass="35062" checksum="5E0DEE1DA3953DB1" modified="2011-12-14" version="1">MAEQLVLRGTLEGHNGWVTSLATSLENPNMLLSGSRDKTLIIWNLTRDEQAYGYPKRSLEGHSHIVSDCVISSDGAYALSASWDKSLRLWELSSGQTTRTFVGHTNDVLSVSFSADNRQIVSGSRDRTIKLWNTLGDCKYTITDKGHTEWVSCVRFSPNPQNPVIVSAGWDKLVKVWELASCRLQTDHIGHTGYINTVTISPDGSLCASGGKDGVTMLWDLNESKHLYSLHAGDEIHALVFSPNRYWLCAATSSSITIFDLEKKSKVDELKPEYIEKGKKSREPECVSLAWSADGQTLFAGYTDNKIRAWGVMSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-12-14" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>G5EB60</accession>
    <accession>C8VTA8</accession>
    <name>G5EB60_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Gfo/Idh/MocA-like oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_01139</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
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        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF88067.1"/>
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    <dbReference type="RefSeq" id="XP_658743.1">
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    <dbReference type="HOGENOM" id="CLU_023194_1_1_1"/>
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    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
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    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051450">
        <property type="entry name" value="Gfo/Idh/MocA_Oxidoreductases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43377">
        <property type="entry name" value="BILIVERDIN REDUCTASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43377:SF1">
        <property type="entry name" value="BILIVERDIN REDUCTASE A"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="1">
        <location>
            <begin position="13"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase C-terminal" evidence="2">
        <location>
            <begin position="158"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF88067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="398" mass="43159" checksum="CA15A8EF81A588C1" modified="2011-12-14" version="1">MVPCSKEKDKNILIVIVGAGLIGPRHAQSVQRHPRTQLIAFVDPSPSAIPVAESFGVPCYDSITSMLDVVGKTTGKPDAAIVSTPNHTHVDVTLQLLENGIRNILLEKPISDDLESAEHLLATVKEQKCKDEKRGKDAKINIQIGHHRRFNPYIQTTKSLLETDSLGTVVAVNGLWTLLKPASYFAPPLGSWRADKKKGGVLGINLIHDIDVLQFLFGPVSRVYAEGTLLQRMRQNPEHTAEEGCAVTLRFASGIVGTFLICDATPSPLNFETGTGENPTIPPAPSKSASDCYRILGTRASLSVPDMTRWSYDHVSCGQGKEKGWNTELAMQQISVKDADVRPFDAQWGYFVDVVSGKGEDGERGVGCGVEDGVRALRVVQAVRESMEGGKPVDVQSV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1993-10-01" modified="2025-04-09" version="145" xmlns="https://uniprot.org/uniprot">
    <accession>Q01981</accession>
    <accession>C8V211</accession>
    <accession>Q5AZT5</accession>
    <name>CREA_EMENI</name>
    <protein>
        <recommendedName>
            <fullName>DNA-binding protein creA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Carbon catabolite repressor A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">creA</name>
        <name type="ORF">AN6195</name>
    </gene>
    <organism>
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1991" name="Mol. Cell. Biol." volume="11" first="5701" last="5709">
            <title>Analysis of the creA gene, a regulator of carbon catabolite repression in Aspergillus nidulans.</title>
            <authorList>
                <person name="Dowzer C.E.A."/>
                <person name="Kelly J.M."/>
            </authorList>
            <dbReference type="PubMed" id="1922072"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="1994" name="EMBO J." volume="13" first="4022" last="4027">
            <title>The Aspergillus nidulans CREA protein mediates glucose repression of the ethanol regulon at various levels through competition with the ALCR-specific transactivator.</title>
            <authorList>
                <person name="Mathieu M."/>
                <person name="Felenbok B."/>
            </authorList>
            <dbReference type="PubMed" id="8076597"/>
        </citation>
        <scope>CHARACTERIZATION</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2001" name="Mol. Microbiol." volume="40" first="1311" last="1321">
            <title>Carbon catabolite repression in Aspergillus nidulans involves deubiquitination.</title>
            <authorList>
                <person name="Lockington R.A."/>
                <person name="Kelly J.M."/>
            </authorList>
            <dbReference type="PubMed" id="11442830"/>
            <dbReference type="DOI" id="10.1046/j.1365-2958.2001.02474.x"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2008" name="Curr. Genet." volume="54" first="47" last="55">
            <title>The interaction of induction, repression and starvation in the regulation of extracellular proteases in Aspergillus nidulans: evidence for a role for CreA in the response to carbon starvation.</title>
            <authorList>
                <person name="Katz M.E."/>
                <person name="Bernardo S.M."/>
                <person name="Cheetham B.F."/>
            </authorList>
            <dbReference type="PubMed" id="18512059"/>
            <dbReference type="DOI" id="10.1007/s00294-008-0198-6"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2008" name="Fungal Genet. Biol." volume="45" first="657" last="670">
            <title>CreA-mediated repression in Aspergillus nidulans does not require transcriptional auto-regulation, regulated intracellular localisation or degradation of CreA.</title>
            <authorList>
                <person name="Roy P."/>
                <person name="Lockington R.A."/>
                <person name="Kelly J.M."/>
            </authorList>
            <dbReference type="PubMed" id="18063396"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2007.10.016"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <reference key="8">
        <citation type="thesis" date="2008" institute="University of Adelaide, Australia">
            <title>Identifying target proteins of the CreB deubiquitination enzyme in the fungus Aspergillus nidulans.</title>
            <authorList>
                <person name="Kamlangdee N."/>
            </authorList>
        </citation>
        <scope>UBIQUITINATION</scope>
        <scope>INTERACTION WITH CREB</scope>
        <scope>DEUBIQUITINATION BY CREB</scope>
    </reference>
    <reference key="9">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="613" last="613">
            <title>Elucidating how the saprophytic fungus Aspergillus nidulans uses the plant polyester suberin as carbon source.</title>
            <authorList>
                <person name="Martins I."/>
                <person name="Hartmann D.O."/>
                <person name="Alves P.C."/>
                <person name="Martins C."/>
                <person name="Garcia H."/>
                <person name="Leclercq C.C."/>
                <person name="Ferreira R."/>
                <person name="He J."/>
                <person name="Renaut J."/>
                <person name="Becker J.D."/>
                <person name="Silva Pereira C."/>
            </authorList>
            <dbReference type="PubMed" id="25043916"/>
            <dbReference type="DOI" id="10.1186/1471-2164-15-613"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="4 5 6">Transcription regulator component of the regulatory network controlling carbon source utilization through ubiquitination and deubiquitination involving creA, creB, creC, creD and acrB. Represses the transcription of the alcR, alcA and aldA genes by binding to a GC-rich region in their promoter. Also plays a role in response to carbon starvation and the control of extracellular proteases activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Interacts with creB.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="7">Induced during growth on suberin.</text>
    </comment>
    <comment type="PTM">
        <text evidence="1">Ubiquitinated. Deubiquitinated by creB, probably to control its activity or amount.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the creA/MIG C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EMBL" id="AY219921">
        <property type="protein sequence ID" value="AAR02858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AACD01000105">
        <property type="protein sequence ID" value="EAA57981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF69992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="A41694">
        <property type="entry name" value="A41694"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_663799.1">
        <property type="nucleotide sequence ID" value="XM_658707.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q01981"/>
    <dbReference type="SMR" id="Q01981"/>
    <dbReference type="STRING" id="227321.Q01981"/>
    <dbReference type="EnsemblFungi" id="CBF69992">
        <property type="protein sequence ID" value="CBF69992"/>
        <property type="gene ID" value="ANIA_06195"/>
    </dbReference>
    <dbReference type="GeneID" id="2870784"/>
    <dbReference type="KEGG" id="ani:ANIA_06195"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN6195"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036230_0_0_1"/>
    <dbReference type="InParanoid" id="Q01981"/>
    <dbReference type="OMA" id="YHMARSH"/>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009051">
        <property type="term" value="P:pentose-phosphate shunt, oxidative branch"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043609">
        <property type="term" value="P:regulation of carbon utilization"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000089">
        <property type="entry name" value="DNA-binding protein creA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000152">
        <property type="entry name" value="DNA-binding protein creA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051007">
        <property type="entry name" value="creA/MIG_C2H2-ZnF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47428">
        <property type="entry name" value="REGULATORY PROTEIN MIG1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47428:SF1">
        <property type="entry name" value="REGULATORY PROTEIN MIG1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0678">Repressor</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <keyword id="KW-0832">Ubl conjugation</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <keyword id="KW-0863">Zinc-finger</keyword>
    <feature type="chain" id="PRO_0000046875" description="DNA-binding protein creA">
        <location>
            <begin position="1"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C2H2-type 1" evidence="2">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C2H2-type 2" evidence="2">
        <location>
            <begin position="92"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="145"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="220"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="340"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="395"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="230"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="279"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="395"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="11442830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="18063396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="6">
        <source>
            <dbReference type="PubMed" id="18512059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="7">
        <source>
            <dbReference type="PubMed" id="25043916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="8">
        <source ref="8"/>
    </evidence>
    <evidence type="ECO:0000305" key="9"/>
    <sequence length="416" mass="44729" checksum="487EC100A228145E" modified="1993-10-01" version="1">MPQPGSSVDFSNLLNPQNNTAIPAEVSNATASATMASGASLLPPMVKGARPAAEEARQDLPRPYKCPLCERAFHRLEHQTRHIRTHTGEKPHACQFPGCSKRFSRSDELTRHSRIHNNPNSRRGNKAQHLAAAAAAAAANQDGSAMANNAGSMMPPPSKPITRSAPVSQVGSPDISPPHSFSNYANHMRSNLSPYSRTSERASSGMDINLLATAASQVERDESFGFRSGQRSHHMYGPRHGSRGLPSLSAYAISHSMSRSHSHEDEDSYASHRVKRSRPNSPNSTAPSSPTFSHDSLSPTPDHTPLATPAHSPRLKPLSPSELHLPSIRHLSLHHTPALAPMEPQAEGPNYYNPNQPHVGPSISDIMSRPEGAQRKLPIPQVPKVAVQDMLNPSGFTSVSSSTANSVAGGDLAERF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AQG8</accession>
    <accession>C8V6R8</accession>
    <name>Q5AQG8_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF952 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ANIA_09462</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF75308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_868844.1">
        <property type="nucleotide sequence ID" value="XM_863751.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AQG8"/>
    <dbReference type="STRING" id="227321.Q5AQG8"/>
    <dbReference type="GeneID" id="3684059"/>
    <dbReference type="KEGG" id="ani:ANIA_09462"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN9462"/>
    <dbReference type="eggNOG" id="ENOG502SBXH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129452_2_0_1"/>
    <dbReference type="InParanoid" id="Q5AQG8"/>
    <dbReference type="OMA" id="NDEGWDK"/>
    <dbReference type="OrthoDB" id="3335358at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.170.20">
        <property type="entry name" value="Protein of unknown function DUF952"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009297">
        <property type="entry name" value="DUF952"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34129">
        <property type="entry name" value="BLR1139 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34129:SF1">
        <property type="entry name" value="DUF952 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06108">
        <property type="entry name" value="DUF952"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF75308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="133" mass="15243" checksum="43FCDA4F41965724" modified="2005-04-26" version="1">MPRSEPTFLYKLVPSTSPVREPIPDRLPVSELDEMSGFVHLSTALQVPNTLKFFFKDEPLVYVLRIPYDRVAKDIRFEDPEGRVCGPRPDEGLFPHLYNGLKLGKDEVESLSIWTNEGGWDKPLAAAKPWLRY</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-10-19" modified="2026-01-28" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AQN0</accession>
    <accession>C8VRK3</accession>
    <name>GATA_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial</fullName>
            <shortName evidence="1">Glu-AdT subunit A</shortName>
            <ecNumber evidence="1">6.3.5.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="ORF">AN9400</name>
    </gene>
    <organism>
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-glutamyl-tRNA(Gln) + L-glutamine + ATP + H2O = L-glutaminyl-tRNA(Gln) + L-glutamate + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.7"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A, B and C subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the amidase family. GatA subfamily.</text>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="erroneous gene model prediction">
            <sequence resource="EMBL-CDS" id="CBF87540" version="1"/>
        </conflict>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="erroneous gene model prediction">
            <sequence resource="EMBL-CDS" id="EAA66467" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EC" id="6.3.5.7" evidence="1"/>
    <dbReference type="EMBL" id="AACD01000172">
        <property type="protein sequence ID" value="EAA66467.1"/>
        <property type="status" value="ALT_SEQ"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF87540.1"/>
        <property type="status" value="ALT_SEQ"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_682669.1">
        <property type="nucleotide sequence ID" value="XM_677577.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AQN0"/>
    <dbReference type="SMR" id="Q5AQN0"/>
    <dbReference type="FunCoup" id="Q5AQN0">
        <property type="interactions" value="324"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5AQN0"/>
    <dbReference type="KEGG" id="ani:ANIA_09400"/>
    <dbReference type="eggNOG" id="KOG1211">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009600_7_6_1"/>
    <dbReference type="InParanoid" id="Q5AQN0"/>
    <dbReference type="OrthoDB" id="421993at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030956">
        <property type="term" value="C:glutamyl-tRNA(Gln) amidotransferase complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070681">
        <property type="term" value="P:glutaminyl-tRNAGln biosynthesis via transamidation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00120">
        <property type="entry name" value="GatA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004412">
        <property type="entry name" value="GatA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895:SF7">
        <property type="entry name" value="GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE SUBUNIT A, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000413353" description="Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial">
        <location>
            <begin position="1"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="1">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="1">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="1">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="506" mass="55011" checksum="3041D12FED70674E" modified="2011-10-19" version="2">MSLLLEAERYVANQSSNRMLNAFITPLCRHSGRWHDQAKDADIRGKQGKLRSRLDGRFIAFKDNICTRDFPTTCASKSLDTFTSPFNATVVQQLEDAGAIVAGKTNLDEFGMGSHSIYSSFGHVMNTRRGDDSKFLSAGGSSGGNAVAVATDQCYAALGTDTGGSIRLPAAYTGTVGFKPSYGLLSRWGVIAYANSLDTVGILAKRVSVARDVFDVLNKHDPRDPTSISPSSRSRISSKLNLPQLTSRLTSRPLRIGIPLEYNISELAPSVRQAWCHSLEYLRQQGHTIQPVSLPMTKLALSAYYVLAPAEASSNLAKYDGVRYGTRSDDSTENQSETYLYAKTRGAGFGPEVKRRIMLGAFSLSAQAIDNYFIQAQRIRRLVRHDFDAAFQAEHPLAAEIRNVELRQQAKQTGIDVLISPTAPTPPPTISDITDTSTKRSNLDAYINDVFTVPASLAGLPAISVPVSGKDNAGNQEGDILAGIQVIGQYGDDELVLKVGELLERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="117" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AQZ6</accession>
    <accession>C8VQN6</accession>
    <name>Q5AQZ6_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ANIA_09284</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF87330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_682553.1">
        <property type="nucleotide sequence ID" value="XM_677461.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AQZ6"/>
    <dbReference type="GeneID" id="2867892"/>
    <dbReference type="KEGG" id="ani:ANIA_09284"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN9284"/>
    <dbReference type="eggNOG" id="KOG1200">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_0_1"/>
    <dbReference type="InParanoid" id="Q5AQZ6"/>
    <dbReference type="OMA" id="YSNKPTL"/>
    <dbReference type="OrthoDB" id="294295at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43639">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G02870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43639:SF1">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBF87330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="254" mass="27161" checksum="E677B62C9A4684C9" modified="2005-04-26" version="1">MPGRLEGHIALISGSSQGFGRGIFETFLREGALVLGLDLQAIDGQVEGFPENRAYQITANVAEEETWKRALETSIARFGKAPSIVVHNAGWSYPNKSGLDVTVEEFDRLFNVNVRSIYLASKVLVPEMKKNGPGSTIVISSENAIRPGATQTWYNATKAGVSSATKSMALEFARDQLRFNTICPTSGNTPLLNKFAGISDGPVPPEIIKAKCEAIPIGRLVEPSDVANVALFLAEPASSIISGVEILVDGARCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="112" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AR89</accession>
    <accession>C8VJU5</accession>
    <name>Q5AR89_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Luciferase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ANIA_09191</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF82356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_682460.1">
        <property type="nucleotide sequence ID" value="XM_677368.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AR89"/>
    <dbReference type="STRING" id="227321.Q5AR89"/>
    <dbReference type="GeneID" id="2868062"/>
    <dbReference type="KEGG" id="ani:ANIA_09191"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN9191"/>
    <dbReference type="eggNOG" id="ENOG502RY13">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027853_1_4_1"/>
    <dbReference type="InParanoid" id="Q5AR89"/>
    <dbReference type="OMA" id="SCEDPWL"/>
    <dbReference type="OrthoDB" id="2558704at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01094">
        <property type="entry name" value="Alkanesulfonate_monoxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.30:FF:000012">
        <property type="entry name" value="Alkanesulfonate monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="entry name" value="Luciferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050172">
        <property type="entry name" value="SsuD_RutA_monooxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42847">
        <property type="entry name" value="ALKANESULFONATE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42847:SF4">
        <property type="entry name" value="ALKANESULFONATE MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="Bacterial luciferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Luciferase-like" evidence="5">
        <location>
            <begin position="16"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBF82356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="361" mass="40338" checksum="FAED16B6E81B4069" modified="2005-04-26" version="1">MPTEFISLTFPTPSTEIDPIPNAAIDPAFLERYARNLDDYSYNYTLVPYDSSYFDPWTVGATIASHTKNLKIIIAVRPNTLYPTVAAKALATLDQLSSGRAVVHFIAGGSDAEQAREGDFLTKDQRYGRLEDYIKILRRAWESADPFDWESPYYTFKDFSNRVRPVNGTIPVSVGGSSDEAYRIGGSLADIFGLWGEPLKETKEQIDRIYAEAEKADRTDRPRIWVTFRPIVAETDELAWAKAHRTLDALQKNRAAGLGKAPANAPPPQNVGSQRLLEIASRGEVHDRALWYPTVTATNARGASTALVGSWETVSESILDYVELGAELISIRGYDNLNDAIDYGRYILPRVREELKKRGKQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2010-05-18" modified="2025-04-09" version="101" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ARE6</accession>
    <accession>C8VK67</accession>
    <accession>Q1HFQ2</accession>
    <name>RHGA_EMENI</name>
    <protein>
        <recommendedName>
            <fullName>Rhamnogalacturonase A</fullName>
            <shortName>RGase A</shortName>
            <shortName>RHG A</shortName>
            <ecNumber>3.2.1.171</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">rhgA</name>
        <name type="ORF">AN9134</name>
    </gene>
    <organism>
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="11417" last="11422">
            <title>Development and application of a suite of polysaccharide-degrading enzymes for analyzing plant cell walls.</title>
            <authorList>
                <person name="Bauer S."/>
                <person name="Vasu P."/>
                <person name="Persson S."/>
                <person name="Mort A.J."/>
                <person name="Somerville C.R."/>
            </authorList>
            <dbReference type="PubMed" id="16844780"/>
            <dbReference type="DOI" id="10.1073/pnas.0604632103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA]</scope>
        <scope>FUNCTION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Pectinolytic enzymes consist of four classes of enzymes: pectine lyase, polygalacturonase, pectin methylesterase and rhamnogalacturonase. Hydrolyzes alpha-D-galacturonopyranosyl-(1,2)-alpha-L-rhamnopyranosyl linkages in the backbone of the hairy regions of pectins. Active against linseed rhamnogalacturonan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>Endohydrolysis of alpha-D-GalA-(1-&gt;2)-alpha-L-Rha glycosidic bond in the rhamnogalacturonan I backbone with initial inversion of anomeric configuration releasing oligosaccharides with beta-D-GalA at the reducing end.</text>
            <dbReference type="EC" id="3.2.1.171"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <comment type="sequence caution" evidence="5">
        <conflict type="erroneous gene model prediction">
            <sequence resource="EMBL-CDS" id="CBF82482" version="1"/>
        </conflict>
    </comment>
    <comment type="sequence caution" evidence="5">
        <conflict type="erroneous gene model prediction">
            <sequence resource="EMBL-CDS" id="EAA61967" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EC" id="3.2.1.171"/>
    <dbReference type="EMBL" id="DQ490522">
        <property type="protein sequence ID" value="ABF50898.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AACD01000169">
        <property type="protein sequence ID" value="EAA61967.1"/>
        <property type="status" value="ALT_SEQ"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF82482.1"/>
        <property type="status" value="ALT_SEQ"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_682403.1">
        <property type="nucleotide sequence ID" value="XM_677311.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ARE6"/>
    <dbReference type="SMR" id="Q5ARE6"/>
    <dbReference type="STRING" id="227321.Q5ARE6"/>
    <dbReference type="CAZy" id="GH28">
        <property type="family name" value="Glycoside Hydrolase Family 28"/>
    </dbReference>
    <dbReference type="GlyCosmos" id="Q5ARE6">
        <property type="glycosylation" value="2 sites, No reported glycans"/>
    </dbReference>
    <dbReference type="KEGG" id="ani:ANIA_09134"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN9134"/>
    <dbReference type="eggNOG" id="ENOG502R2FT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016031_7_2_1"/>
    <dbReference type="InParanoid" id="Q5ARE6"/>
    <dbReference type="OrthoDB" id="2268901at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046576">
        <property type="term" value="F:rhamnogalacturonan alpha-L-rhamnopyranosyl-(1-&gt;4)-alpha-D-galactopyranosyluronide lyase activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000025">
        <property type="entry name" value="Probable rhamnogalacturonase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024535">
        <property type="entry name" value="RHGA/B-epi-like_pectate_lyase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736:SF19">
        <property type="entry name" value="PECTIN LYASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12708">
        <property type="entry name" value="Pect-lyase_RHGA_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword id="KW-1015">Disulfide bond</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0326">Glycosidase</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0624">Polysaccharide degradation</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000394385" description="Rhamnogalacturonase A">
        <location>
            <begin position="22"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="462"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="462"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="492"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="215"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="290"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="235"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="317"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="38"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="217"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="340"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="368"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="16844780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <sequence length="507" mass="53449" checksum="AE6347D789F560C1" modified="2010-05-18" version="2" precursor="true">MYVSRLLLFLAPLLVKGQLSGSVGPLTSVSSKSQTKTCNVLDYGAVADKSTDIGPALSSAWDECADGGVVYIPPGDYAIETWVKLSGGKACAIQLDGIIYRTGTDGGNMIMIEHTSDFEFFSSTSKGAFQGYGYEFHAKGSSDGPRILRLYDVSDFSVHDVALVDSPLFHFSMDTCSNGEVYNMAIRGGNMGGLDGIDVWSTNVWIHDVEVTNKDECVTVKSPSKNILVENIYCNWSGGCAMGSLGTDTDISDIVYRNVYTWKSNQMYMVKSNGGSGTVSNLVLENFIGHGNAYSLDIDSAWSSMSTIEGDGVELKNVTIRNWKGTEADGSQRGPIKVKCASGAPCTDVTVEDFAMWTESGDEQTYVCENAFGDGFCLADGDGTSTFTTTLTASAAPSGYSAPSMDADLETAFGTDSEIPIPTIPTSFYPGATPYSALAGASVSSSQVPAASSSAEAKFVASPATSSPTATSTAISSVDPVSAATTTATSHGHGKSHHKHQCRAHRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ARE8</accession>
    <accession>C8VK69</accession>
    <name>Q5ARE8_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_09132</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF82486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_682401.1">
        <property type="nucleotide sequence ID" value="XM_677309.1"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5ARE8"/>
    <dbReference type="GeneID" id="2867965"/>
    <dbReference type="KEGG" id="ani:ANIA_09132"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN9132"/>
    <dbReference type="eggNOG" id="ENOG502QUPQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_245818_0_0_1"/>
    <dbReference type="InParanoid" id="Q5ARE8"/>
    <dbReference type="OMA" id="QNVHKQF"/>
    <dbReference type="OrthoDB" id="4510966at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017956">
        <property type="entry name" value="AT_hook_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02178">
        <property type="entry name" value="AT_hook"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00929">
        <property type="entry name" value="ATHOOK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00384">
        <property type="entry name" value="AT_hook"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="1495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1521"/>
            <end position="1563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="198"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="338"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="391"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="413"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="423"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="502"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="521"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="573"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="630"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="734"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="773"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="806"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="825"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="872"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="902"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="932"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1023"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1054"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1069"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1113"/>
            <end position="1159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1160"/>
            <end position="1177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1186"/>
            <end position="1197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1198"/>
            <end position="1208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1220"/>
            <end position="1248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1268"/>
            <end position="1285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1292"/>
            <end position="1302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1303"/>
            <end position="1316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1318"/>
            <end position="1334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1345"/>
            <end position="1393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1406"/>
            <end position="1431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1432"/>
            <end position="1445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1460"/>
            <end position="1493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1521"/>
            <end position="1544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF82486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="1563" mass="170806" checksum="5E5C2EBCF0D1B8E0" modified="2005-04-26" version="1">MMDYGGHQYHQQQQPHPHPQSQQNAHLQQHHVQSPAIGAAAARQSANANANANANANAFASNSSLYRSQSQADMTGLSPSVRNMTTSSQSLLGLPAGTSYGSFSGQFQPTSTSNLLSRSSDSLGQLRSSYDSLQGVQRNMNPVTNYRHTSLNSQTLSPHAQGLSTSPQQSLDRMQQLQRQSPHTQSTSAPSNASPMLSHSQNQQYTQYQQSSPYQTQSAQYQQPVSQYQQPQKTQPTQYQQPQQYRQPQQAQYTPQTQSSPYLPQTQYPQYPSSQQPPYQQLQNYQQQQKSAQVPQSSQQSYPQQTQIPQTSQQNYQQASAQRAPQTSPVQQGYQQNSTSAQQAPQLSQQSYAPQAQKSAQGPQASPVKQSYQQPGQKPSHAGQQSYQHTAQSSAQQLPQSSQQSFLLSSAQVPQSSQQKGYQQASTQQVPQSSQPSYPQQVNKPAQLPQLSQQQSYLPGPTQVSQSSQQKSYQQAGQQGLQSSQQSYPQQAQTSAQAQSSPHVQQYQQHAQKSHHVLHPQAQQVQQNQKAARPSQPSQAQAKPSPLQSQQAQQVQVQANHTSASNAHPAQANPQPQRASQQVQAQQPAQSQKTSQQAQNQQTLPNQAYQQFYSQHAQQAQRSPYQTHMQNPQYPYTYQPQFAQQYMQSPQLRTSQATQQQYQSQQSQTSQSQSPQQSVMQKQPTTQLQQEQQPRSQAQAQPQKPPAQTNQLASKPPAKEPKKKKASKKEAKQKPAASQAVSQTASQPAPQARASQTAASQAPPQAKGSQVTAQSSASQPYASQTYGSQAPAYQFHAQASQPYAPQAHTQQNTFQTTTSQAHAAPTNSFQTNTSQSHGQAHSFQVPVSQPHASQMNTFQATPQANSLGAQGSQPTQIPSQPSTQPKVESLSQQSQPSQQVQPTTNGNGQASGTFITENPTQKKTKPGDPNHTPRKRGRPRKQPGEATKPRKPKRPRNPDGTVDLSAALPPNLAAIPGVGIPFSIAPNPPPAPPASTASSAPPAPVIGLDGNPIPQKRKRGRPRKSEADGTPRKPRPPRDPNRPKGTGRPRGRPRKVDVLARKKLEEEQAAAAAAAAHAADQNSQPGAGQPAATQAPPSQAQHGHMQAGHVQVKVNQTSQGQPSKGQGQIHQWQVNQANQSHVSQAQANQAPTNRAQVTHQTSQGQATQGQAQWQISQGKSGSGREQVGQGQFGQSVQAPSGQTNQYAQGTHPGHAHPSHGHPSQAPVQPQSQNQAARPQGQQQMQPQQHARHTHAQQAQPMQNQLRGSPMQSMQASPMQSMQASPLQNQIGQRQPVQRPPVQTSSQRPQSHLQAQVNAKPQMQVQPQKAQPQMQNHMQAKPVVHAQTTKTQGQTQQVQQAQQAQVQQAPAQGQPQKAQVQQLAQPLQMQRQAPSPMQTPAQRPHQPHLLGHGQSQLHHAQAQQGQIQGQAQTRSPTSQAQAQTHNLGKAHPHAQPTQQAHSSYPTHSTHSSHSTHSSHSAQSAQSASYPHSHPYQPQFQEQIPQLHMHSQLHHLNQQHPVYSQFSQRQQQPSMTLNPQTGQKRPSSVLDDDPRKRAYIMPHQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ARU6</accession>
    <accession>C8VL18</accession>
    <name>Q5ARU6_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ANIA_08984</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF84517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_682253.1">
        <property type="nucleotide sequence ID" value="XM_677161.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ARU6"/>
    <dbReference type="GeneID" id="2868250"/>
    <dbReference type="KEGG" id="ani:ANIA_08984"/>
    <dbReference type="HOGENOM" id="CLU_028200_3_7_1"/>
    <dbReference type="InParanoid" id="Q5ARU6"/>
    <dbReference type="OMA" id="DITWSWA"/>
    <dbReference type="OrthoDB" id="3923077at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF146">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="123"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="26"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBF84517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="349" mass="38394" checksum="EFA1037ECBBF08EF" modified="2005-04-26" version="1">MAGDERVSITAVSWTLGTLSILLVALRLYTRLLITRCRGWDDLFVTIALVNAIICSALTQIAVSHGLGKHEADIPNPNDRISAAKYATIAPSFSVISTVTGKISVVIFLLRLLTLSAKPWHRWFLHSLTLASIAWNILGIVAIIGYCRPTRKIWLPETEGSCMSSRFQLVAGISQSAFNAFADWALALFPAILFRKVQLPLLKKVVVIAVLGSGVLDMARHHEMVYVELRQQPKIWNEQMYLIIICASVPTMPQSLNALLHLCKTYHKYNSSSSRCNLSRPSIREPGVLLKRMQDSSLFDAPAEHAGSQENILACNEGELNTNIGCMIDLTVAQDSDIGDIVLVQGGTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ARU8</accession>
    <accession>C8VL20</accession>
    <name>Q5ARU8_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Hypothetical fructosyl amine:oxygen oxidoreductase (Eurofung)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ANIA_08982</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MSOX/MTOX family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF84521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_682251.1">
        <property type="nucleotide sequence ID" value="XM_677159.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ARU8"/>
    <dbReference type="STRING" id="227321.Q5ARU8"/>
    <dbReference type="GeneID" id="2868251"/>
    <dbReference type="KEGG" id="ani:ANIA_08982"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN8982"/>
    <dbReference type="eggNOG" id="KOG2820">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007884_0_2_1"/>
    <dbReference type="InParanoid" id="Q5ARU8"/>
    <dbReference type="OMA" id="LSETMPQ"/>
    <dbReference type="OrthoDB" id="2219495at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051698">
        <property type="term" value="F:saccharopine oxidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008115">
        <property type="term" value="F:sarcosine oxidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045170">
        <property type="entry name" value="MTOX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961:SF24">
        <property type="entry name" value="HYPOTHETICAL FRUCTOSYL AMINE:OXYGEN OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961">
        <property type="entry name" value="PEROXISOMAL SARCOSINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="6">
        <location>
            <begin position="10"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBF84521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="438" mass="48939" checksum="2A4EA670B18296EC" modified="2005-04-26" version="1">MSQLTKDSSILIIGGGTWGCSTALQLARAGYKNVTVLERSPIPSPSAAGNDVNKIMEEGAPSDTDTPEQYVWNRMHQITANAWKTDPVFRPFYHPTGFIMAASQDDAMPHVDKYISTCRDKLRLLNSAADFRATMPLGVLTGDFSGWKGFFREAGAGWVFARGALEAAYKEASRLGVKFVTGDEGGVKSLLYTDDQSDIVGAKTADEKEHRADRVILCAGAGSDQLLDFEKQLRPTAWTLAHIQMTEEERKLWKDLPVLFNVNSGFFIEPDSTGQLKFVDEHPGYCNIPTSEVLNDFPKSIPFAKHQIPLQSEHAARQFLRDTVPQIADRPFAFARICWDADTPDRQFLIDQHPKYKSLTVAVGGSGNGFMMMPAVGIAIKQRLEGVLEEKLKYAFRWRPETAVHRDWRDTQDRFGGTGTVRNFQDVEVWTRVGEEII</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="117" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ASD7</accession>
    <accession>C8V9P5</accession>
    <accession>Q30KV3</accession>
    <name>Q5ASD7_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">ANIA_08793</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome b560 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF78009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_682062.1">
        <property type="nucleotide sequence ID" value="XM_676970.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ASD7"/>
    <dbReference type="FunCoup" id="Q5ASD7">
        <property type="interactions" value="359"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5ASD7"/>
    <dbReference type="GeneID" id="2868433"/>
    <dbReference type="KEGG" id="ani:ANIA_08793"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN8793"/>
    <dbReference type="eggNOG" id="KOG0449">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094691_0_2_1"/>
    <dbReference type="InParanoid" id="Q5ASD7"/>
    <dbReference type="OMA" id="LTWMLSG"/>
    <dbReference type="OrthoDB" id="588261at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045273">
        <property type="term" value="C:respiratory chain complex II (succinate dehydrogenase)"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006121">
        <property type="term" value="P:mitochondrial electron transport, succinate to ubiquinone"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03499">
        <property type="entry name" value="SQR_TypeC_SdhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1300.10:FF:000008">
        <property type="entry name" value="Succinate dehydrogenase cytochrome b560 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.10">
        <property type="entry name" value="Fumarate reductase/succinate dehydrogenase, transmembrane subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034804">
        <property type="entry name" value="SQR/QFR_C/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018495">
        <property type="entry name" value="Succ_DH_cyt_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014314">
        <property type="entry name" value="Succ_DH_cytb556"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000701">
        <property type="entry name" value="SuccDH_FuR_B_TM-su"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02970">
        <property type="entry name" value="succ_dehyd_cytB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10978">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE CYTOCHROME B560 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10978:SF5">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE CYTOCHROME B560 SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01127">
        <property type="entry name" value="Sdh_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81343">
        <property type="entry name" value="Fumarate reductase respiratory complex transmembrane subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01000">
        <property type="entry name" value="SDH_CYT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01001">
        <property type="entry name" value="SDH_CYT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00007244"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CBF78009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="191" mass="21151" checksum="091D5FA6BDAE6942" modified="2005-04-26" version="1">MLSQKVAQQSLRRLAVQQPYAMRWSLMNAASPAAVAMGRNVQKIQTRFAATSTTTSDPNKILVEQRLRRPVSPHLTIYRPQITWYMSALHRVTGIILSGPLYIFATAYLAAPLFGWHLESASLAASFATLPLAAKFSLKTLAALPFTYHSFNGLRHLMWDTGRGITNKQVIQTGWTVVGLSIASALYLAYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ASF5</accession>
    <accession>C8V9R4</accession>
    <name>Q5ASF5_EMENI</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ANIA_08775</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF78045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_676952.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ASF5"/>
    <dbReference type="GeneID" id="2868319"/>
    <dbReference type="KEGG" id="ani:ANIA_08775"/>
    <dbReference type="eggNOG" id="ENOG502RX10">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_633168_0_0_1"/>
    <dbReference type="InParanoid" id="Q5ASF5"/>
    <dbReference type="OMA" id="FTYLWAN"/>
    <dbReference type="OrthoDB" id="4225822at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF78045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="433" mass="45432" checksum="0E99D019C7799286" modified="2005-04-26" version="1">MTYHSTGVHDPAGAAAAGIKGKKKSFHSVQISIYKTREVAPTQSYPQSGKAGKAGTHAMKPLTCALISLFAACVCNGELLPTLPFPLPICTSTTTLTLGGTYTVTATSTVTSISISQTRTTIYTPTSVTCLSTATTLAAYPSLPGLDADTGASILKVRAASPQITLPPILPIGCPTVTVIPPTVSNAPCTRLEGGFALTYATISSPSHRLRQASLGGRELKSTVRTSTITTTKSGIATVTTTPISTQIVTETWIQPTPTNYNGICLPLPLLRNSPLPALSHANHLSTGLNYYQYLNGYNYNTDTTGLGGGGYSTSHWNGNLSYYTSGLARNINFESPNWPTGPAVCQLPGQAAQTDCSQWTVVFQGFLFASIAGNYTVHSPILAESANWQDNTGFWWGGEKAYTDYTDGNVDGAAAPSCGVDTVKRVRVGAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ASL9</accession>
    <accession>C8VA35</accession>
    <name>Q5ASL9_EMENI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_08711</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF78185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_681980.1">
        <property type="nucleotide sequence ID" value="XM_676888.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ASL9"/>
    <dbReference type="GeneID" id="2868569"/>
    <dbReference type="KEGG" id="ani:ANIA_08711"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN8711"/>
    <dbReference type="eggNOG" id="ENOG502T1M6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1468853_0_0_1"/>
    <dbReference type="InParanoid" id="Q5ASL9"/>
    <dbReference type="OMA" id="IRSWCAR"/>
    <dbReference type="OrthoDB" id="5238363at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF78185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="216" mass="24670" checksum="C2D028AF463EAA77" modified="2005-04-26" version="1">MKTIGPKNLYTARFSPNQIISPIAHRYLTARVNPITPKIQYLCDNRDRNTLWWRVSVSALVSYKRVVRSWVARRARAAFKQELKERGFDAEGRRLDSSTPRSAAAHGFSGNMTGTLNIDLEPAMISATFPMIREEMKFTMNALIQEQQRKQASQQQPRKQARKAIRSPTDASVPEQPREQTPFQRPRKQMSRKESAQSAGGKVYRNSIERGGGTRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AST1</accession>
    <accession>C8VAB9</accession>
    <name>Q5AST1_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_08649</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF78258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_681918.1">
        <property type="nucleotide sequence ID" value="XM_676826.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AST1"/>
    <dbReference type="GeneID" id="2868498"/>
    <dbReference type="KEGG" id="ani:ANIA_08649"/>
    <dbReference type="eggNOG" id="ENOG502SZ82">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098702_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AST1"/>
    <dbReference type="OMA" id="IEGRYYT"/>
    <dbReference type="OrthoDB" id="4232400at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40628">
        <property type="entry name" value="CHROMO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40628:SF1">
        <property type="entry name" value="CHROMO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF78258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="225" mass="25205" checksum="A29C3F3084A97E88" modified="2005-04-26" version="1">MRTHDDFMRDVDTTANPLHNDTAEEDTRRKKTRIVHPSTQICRDWMIVSGNVHYARDKASFVPSSYTPISAMLKSNIFSPHDEMLVAGIGDVHLTVPRGINDPNVHTLVLENVLHIPEALCNGFNPLLIGSSMSCHAEYWEGCDRWGNGMWYGTRFCGVGRLVLAPGDGQAESDLIEGREYTLSLYVSPEEKRMIIEQAQRLRSQEQTNGQALGMDGMQMIGSQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="102" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AT24</accession>
    <accession>C8VES6</accession>
    <name>Q5AT24_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Amino acid transporter (Eurofung)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ANIA_08556</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF80792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_681825.1">
        <property type="nucleotide sequence ID" value="XM_676733.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AT24"/>
    <dbReference type="STRING" id="227321.Q5AT24"/>
    <dbReference type="GeneID" id="2868662"/>
    <dbReference type="KEGG" id="ani:ANIA_08556"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN8556"/>
    <dbReference type="eggNOG" id="KOG1286">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_653870_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AT24"/>
    <dbReference type="OMA" id="YLHIRFR"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003333">
        <property type="term" value="P:amino acid transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF1">
        <property type="entry name" value="GENERAL AMINO-ACID PERMEASE GAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="105"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="252"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="288"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="8">
        <location>
            <begin position="3"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBF80792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="420" mass="46569" checksum="208C5C85F9C03EE9" modified="2005-04-26" version="1">MALANVFHFKVYGYFEYYMGFIKCAVVILMICFLFIMASGGIPAAHGPLVFSYWKNPGAFNNGIKGIAKSFVQAAFSFGGGEHIAVIAGEVAPPRSTIRKTVRPVFWRMFTFFVVDIWLVGMDAGSPFVIALKRADVWGLAHAINGFIFLSVISCGVTSVYVASRSLTALADLGLVHRTLGKKDATGRPWVAIAVSLAIGVGLRYLNVDGTGSIVAIVTLFQWASIYIAHLRFRTGLLAQGRNLADLPLKGLLTPYAQCFSLLIVLFIFGCEFYLACFPFGEKGSAKSFFSTYLAAPLFFFDYGVYKWWFKTRIVKPSEMDFSAAVVFDNMEQADRIALEEKAKHGKKSWLKRVQYMNDRPSVFLWASIHPAAPTPYALLSQNAQSTIWNIGEKGYHTDRPRCSADLPFSYGHGRGMTYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ATA3</accession>
    <accession>C8VEI9</accession>
    <name>Q5ATA3_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Xylosidase: arabinofuranosidase (AFU_orthologue AFUA_2G13190)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ANIA_08477</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF80630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_681746.1">
        <property type="nucleotide sequence ID" value="XM_676654.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ATA3"/>
    <dbReference type="STRING" id="227321.Q5ATA3"/>
    <dbReference type="CAZy" id="GH43">
        <property type="family name" value="Glycoside Hydrolase Family 43"/>
    </dbReference>
    <dbReference type="GeneID" id="2868609"/>
    <dbReference type="KEGG" id="ani:ANIA_08477"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN8477"/>
    <dbReference type="eggNOG" id="ENOG502SIVT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016508_3_0_1"/>
    <dbReference type="InParanoid" id="Q5ATA3"/>
    <dbReference type="OMA" id="HEIAWIT"/>
    <dbReference type="OrthoDB" id="408373at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18833">
        <property type="entry name" value="GH43_PcXyl-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041542">
        <property type="entry name" value="GH43_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051795">
        <property type="entry name" value="Glycosyl_Hydrlase_43"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42812">
        <property type="entry name" value="BETA-XYLOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42812:SF17">
        <property type="entry name" value="BETA-XYLOSIDASE C-TERMINAL CONCANAVALIN A-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17851">
        <property type="entry name" value="GH43_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Beta-xylosidase C-terminal Concanavalin A-like" evidence="7">
        <location>
            <begin position="320"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate" evidence="5">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBF80630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="546" mass="60364" checksum="DBA822FCF315EB55" modified="2005-04-26" version="1">MRAYTNPILPGWHSDPSCVYVAEQETFFCATSTFIAFPGLPLYASKDLVHWTLASNIFNRPSQIPSLAVTEDQQGGIYAPTLRYRDGKFYLIVSFLGPNVEGLVFTSDNPYDDDSWSKPVVFPVHGIDPDIFWEEDGQVYVTSADNNQIQHYTLDLATGEIGPVTYLWNGTGGAYPEGPHLFKKADGYYYLLIAEGGTETNHSATMARSRNRTGPWEPCPANPILSNRNTTRYFQTVGHADLFQDGQGHWWGVALSTRSGPEWVNYPMGRETVLTSGTWEDGEWPVLEPVNGIMKAPLPAKQELKNPINRPEHLTFAPGTEIPKHLMYWRFPEESSYVVSPAGHPHTLRLTPSAYGPSYNPASVTDPITFIARRQTDTLFSFSVDLTFSPSSPGVEAGISLFLTQEQHVDVSIVDIARSSSSPARVLQLKTYGRGNYNGSLSNATVEIPKQWVDRTVTLSLEAVDDTTYEFSASLASGPKERVYVGSADARILSGDTGRFTGTLVGVYASRAGHPGGNRTDFAYFSNWKYEGLGQKVDYDVVVPSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ATE1</accession>
    <accession>C8VEE8</accession>
    <name>Q5ATE1_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ANIA_08439</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF80554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_681708.1">
        <property type="nucleotide sequence ID" value="XM_676616.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ATE1"/>
    <dbReference type="GeneID" id="2868651"/>
    <dbReference type="KEGG" id="ani:ANIA_08439"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN8439"/>
    <dbReference type="HOGENOM" id="CLU_1277597_0_0_1"/>
    <dbReference type="InParanoid" id="Q5ATE1"/>
    <dbReference type="OMA" id="IIMDYST"/>
    <dbReference type="OrthoDB" id="10629600at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF80554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="216" mass="23995" checksum="EB966E99789E1BF7" modified="2005-04-26" version="1">MALVYTSYLRLATRVASSPSANSLLIFICSLPPLLLGKHYGKHGTQPETRRNYEREDEQVACGYYQYPLWLSFLLLASTAIELPLILAFHPVTIAYPADILDLPSPGRLTLQVLGLFLMEGLCRRLIRSLVLPVSFKLRKEMDEDQDQEDGEDEHIAEDDIATNAVVDFSTARITLMVGSAILGMPRRGSLTGQLGKLHPLSVAGWAIVDGTWRNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ATJ0</accession>
    <accession>C8VE89</accession>
    <name>Q5ATJ0_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Plasma membrane ammonium transporter (Ato3), putative (AFU_orthologue AFUA_5G01140)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ANIA_08390</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF80443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_681659.1">
        <property type="nucleotide sequence ID" value="XM_676567.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ATJ0"/>
    <dbReference type="GeneID" id="2868698"/>
    <dbReference type="KEGG" id="ani:ANIA_08390"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN8390"/>
    <dbReference type="eggNOG" id="ENOG502S179">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051062_4_0_1"/>
    <dbReference type="InParanoid" id="Q5ATJ0"/>
    <dbReference type="OMA" id="IPIWHIF"/>
    <dbReference type="OrthoDB" id="3648309at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015123">
        <property type="term" value="F:acetate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006068">
        <property type="term" value="P:ethanol catabolic process"/>
        <property type="evidence" value="ECO:0000270"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051633">
        <property type="entry name" value="AceTr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000791">
        <property type="entry name" value="Gpr1/Fun34/SatP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31123">
        <property type="entry name" value="ACCUMULATION OF DYADS PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31123:SF6">
        <property type="entry name" value="MEMBRANE AMMONIUM TRANSPORTER (ATO3), PUTATIVE (AFU_ORTHOLOGUE AFUA_5G01140)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01184">
        <property type="entry name" value="Gpr1_Fun34_YaaH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBF80443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="273" mass="29754" checksum="725B2608FF34321E" modified="2005-04-26" version="1">MSDITDKPSDETINLNRMKTAESVFLPISRETFEKLYLTPKHPSVQTDLRKKFGNPTPICLMGFLIASTPHACMLMGWRGAGGNGSALVPTYIFFGGIVQILGGIGEWIIGNTFSCAIFFTYGTFWLVQGGGLMPFFASGMNYSPTGNSFEGQQTGEYAATIAFYYVFLGLLTFIYLICSIRTNVCLFSALFLLVITFSLVAGAFFQLANGAHELAEKLLVAGGAFNFALCVPVWHIFLTQILEAVDFPISVPVGDLSSIVPGRSQKVKRAED</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ATM8</accession>
    <accession>C8VE45</accession>
    <name>Q5ATM8_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ANIA_08352</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
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    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF80365.1"/>
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        <property type="nucleotide sequence ID" value="XM_676529.1"/>
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    <dbReference type="AlphaFoldDB" id="Q5ATM8"/>
    <dbReference type="STRING" id="227321.Q5ATM8"/>
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    <dbReference type="KEGG" id="ani:ANIA_08352"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_1069690_0_0_1"/>
    <dbReference type="InParanoid" id="Q5ATM8"/>
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        <property type="component" value="Chromosome V"/>
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    <dbReference type="GO" id="GO:0016020">
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        <property type="evidence" value="ECO:0000318"/>
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    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
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        <property type="entry name" value="MFS_trans_sf"/>
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        <property type="entry name" value="PERMEASE-RELATED"/>
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    <dbReference type="PANTHER" id="PTHR43791:SF49">
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    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
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            <begin position="56"/>
            <end position="77"/>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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            <begin position="157"/>
            <end position="178"/>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="210"/>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBF80365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="260" mass="28275" checksum="04298A192E642C7E" modified="2005-04-26" version="1">MTGTQNHEFDHWRHPDGGQWHLWSPVHHRDDGLLVAYFVFEAPSNLALKSFHPHRWLGFLVIAFGALCTGIGFTHTFTEMAVLRFFLGAAEAGVFPGSSHTESGISTVIKAWKAGDGSLYSKESLATVKKGEHLLIYPSEDKLNWNDAKDALCSARYLFLVVATTCVFAGPPSLNAWVGDNVRNTTASSLTIALNIAFSGPGQIIGVWIYRAQDAPAYRLGHAADAVTSAIAAGLALTLTVHYRRTNKKIKGTGDPLWVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AUA2</accession>
    <accession>C8V6P0</accession>
    <name>Q5AUA2_EMENI</name>
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        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
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    <gene>
        <name evidence="1" type="ORF">ANIA_08128</name>
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    <organism evidence="1 2">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
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    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF73942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_681397.1">
        <property type="nucleotide sequence ID" value="XM_676305.1"/>
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    <dbReference type="AlphaFoldDB" id="Q5AUA2"/>
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    <dbReference type="GeneID" id="2869135"/>
    <dbReference type="KEGG" id="ani:ANIA_08128"/>
    <dbReference type="eggNOG" id="ENOG502SMP3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038614_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AUA2"/>
    <dbReference type="OMA" id="HHISPAH"/>
    <dbReference type="OrthoDB" id="5426109at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF73942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="548" mass="62428" checksum="285F8A1F48AD4572" modified="2005-04-26" version="1">MLEPTRNPLLLPEIVGAVLDNVNIRDLLSCAGVNRTWNTLALKRMYEGSVYDLQRRTPDITSLNCLYVASRERFARCMGHVKHLLIAPEHPVEKKDVGMPKKFVSLEKFRPLRDPESAKRLFQAYKPGVKSLMIPFGMHGWEQSYIDVLLTETVEFLAIDDSFCPFLEPAYRPVGNIKALTIYKSGSNRDVTSLCSLIDRCDLHFFHIEDSREPEPMSDDHTTQLIECLARQRNLKALALMIPEVLSPLARVVENGNPWPGLKALYYGQYDDRFSIPPVVRLPRFNELEILSIPRIDPLLTIIGRDPGIKNRLRVLHLELADISDTEPVLDILPGCNSLQKLSLGELDDSGPAEAYANFFQRLPPLPSLQCLVIPWVFKMKINLIQHVASLYPQLTVLDLSQADLTVSLNSLQSMSSITQLQVLQLSEIPFNNPRRWMRGTRLQQLATEWKRVFPSLRTVPYGGDNCTFPMTSQAVREHLLSEPDEFAYPPDSDFLMGRLCTVLGYRARIDSHLDYDFQTKMENEIIGWPVVPFVAFQHTDSYSTYSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AV16</accession>
    <accession>C8V3M5</accession>
    <name>Q5AV16_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Beta-xylosidase C-terminal Concanavalin A-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ANIA_07864</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF73411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_681133.1">
        <property type="nucleotide sequence ID" value="XM_676041.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AV16"/>
    <dbReference type="SMR" id="Q5AV16"/>
    <dbReference type="STRING" id="227321.Q5AV16"/>
    <dbReference type="CAZy" id="GH43">
        <property type="family name" value="Glycoside Hydrolase Family 43"/>
    </dbReference>
    <dbReference type="GeneID" id="2869136"/>
    <dbReference type="KEGG" id="ani:ANIA_07864"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN7864"/>
    <dbReference type="eggNOG" id="ENOG502SM8A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016508_2_1_1"/>
    <dbReference type="InParanoid" id="Q5AV16"/>
    <dbReference type="OMA" id="KLTEAPH"/>
    <dbReference type="OrthoDB" id="2139957at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09000">
        <property type="entry name" value="GH43_SXA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041542">
        <property type="entry name" value="GH43_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051795">
        <property type="entry name" value="Glycosyl_Hydrlase_43"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42812">
        <property type="entry name" value="BETA-XYLOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42812:SF12">
        <property type="entry name" value="BETA-XYLOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17851">
        <property type="entry name" value="GH43_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Beta-xylosidase C-terminal Concanavalin A-like" evidence="8">
        <location>
            <begin position="324"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="15"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate" evidence="6">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBF73411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="540" mass="60905" checksum="9379676DC802EAE4" modified="2005-04-26" version="1">MPPLCNPILPGFNADPSIVRVGSDYYVATSTFEWYPGVQIHHSTDLANWDLVVRPLTRASQLDMRGAPDSCGIWAPCLTHDGDKFWLVYTYVTRKDGSFKDAHNYIVTAPAIEGPWSDPVHVNSSGFDPSLFHDDDGKKWFVNMLWDHRRRPRAFAGIALQEFDPVSGKLVGPMKNIFRGTELDLVEGPHLYKRNGWYYLLTAEGGTAYEHACTLARSRSIWGPYETHPQTHILSSKDAPFAALQRAGHGDLVDTPDGRTYLVHLTGRPVGQSRRCVLGRETAIQEAYWDNNDWLWVKNGPVPSLYVDVPGTRVEKQYWVERRYTFGDGTLHKDFQWLRTPEPQRIFSIENGALSLIGRESIGSWFEQALVARRQTHFSYDAETVLADYTPINERQFAGLVAYYCRYNFFYLAVTADEYGQREINIFRSEASYPEGKLDTPAPDPVRLPNEGRVRLALSIRGGLTLQFFYALEDSDLQPFGPVFDASILSDECGGHQAHGSFTGAFVGMACSDVNGTALPAKFESFVYKPIKDVADRYEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="117" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AVX7</accession>
    <accession>C8VBN9</accession>
    <name>Q5AVX7_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ANIA_07553</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF79619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_680822.1">
        <property type="nucleotide sequence ID" value="XM_675730.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AVX7"/>
    <dbReference type="STRING" id="227321.Q5AVX7"/>
    <dbReference type="GeneID" id="2869684"/>
    <dbReference type="KEGG" id="ani:ANIA_07553"/>
    <dbReference type="eggNOG" id="KOG2483">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017046_1_0_1"/>
    <dbReference type="InParanoid" id="Q5AVX7"/>
    <dbReference type="OMA" id="MQHKQLS"/>
    <dbReference type="OrthoDB" id="8964853at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000111">
        <property type="entry name" value="HLH transcription factor (Hpa3)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10328:SF15">
        <property type="entry name" value="BHLH TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10328">
        <property type="entry name" value="PROTEIN MAX MYC-ASSOCIATED FACTOR X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="5">
        <location>
            <begin position="162"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="261"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="203"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBF79619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="313" mass="34881" checksum="CA35D9B7A986EA41" modified="2005-04-26" version="1">MNQGISSLAINPTSPYHSTNASQTSIVSSLQRERGISTDNNTYRGPRYSGTSPLSPLSSREHRGFAAGRTAPAISSNPRSEIYNAEAPTAGLAYAFPDPDVSTRTQSFDRASFSRKPSATESLYKLPANAHHHHTLQHKQVRGLIGEAEQHSGSTPYSRTPELRVTHKLAERKRRSEMKDCFEALRLRLPSSQNNKSSKWETLTRAIEYINNLEKQVANFRRDNELLHQELQEMRRQLNQQQSNGQSRTASIFEHHQMPVQSNGQVHGPAHGPVYTGYSGSPGAAEEQPRTLPPLMNGSVAPMQGVQYTDDRR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-09-21" modified="2026-01-28" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AXE5</accession>
    <accession>C8VB70</accession>
    <name>LAP1_EMENI</name>
    <protein>
        <recommendedName>
            <fullName>Leucine aminopeptidase 1</fullName>
            <ecNumber>3.4.11.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Leucyl aminopeptidase 1</fullName>
            <shortName>LAP1</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">lap1</name>
        <name type="ORF">AN7035</name>
    </gene>
    <organism>
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Extracellular aminopeptidase that allows assimilation of proteinaceous substrates.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M28 family. M28E subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.-"/>
    <dbReference type="EMBL" id="AACD01000117">
        <property type="protein sequence ID" value="EAA61681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF79215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_664639.1">
        <property type="nucleotide sequence ID" value="XM_659547.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AXE5"/>
    <dbReference type="SMR" id="Q5AXE5"/>
    <dbReference type="FunCoup" id="Q5AXE5">
        <property type="interactions" value="23"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5AXE5"/>
    <dbReference type="MEROPS" id="M28.022"/>
    <dbReference type="GlyCosmos" id="Q5AXE5">
        <property type="glycosylation" value="1 site, No reported glycans"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CBF79215">
        <property type="protein sequence ID" value="CBF79215"/>
        <property type="gene ID" value="ANIA_07035"/>
    </dbReference>
    <dbReference type="GeneID" id="2870117"/>
    <dbReference type="KEGG" id="ani:ANIA_07035"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN7035"/>
    <dbReference type="eggNOG" id="KOG2195">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025866_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AXE5"/>
    <dbReference type="OMA" id="GMLQQDM"/>
    <dbReference type="OrthoDB" id="2214at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd03879">
        <property type="entry name" value="M28_AAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000042">
        <property type="entry name" value="Peptide hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147:SF56">
        <property type="entry name" value="AMINOPEPTIDASE YDR415C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="METALLOPEPTIDASE M28 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0031">Aminopeptidase</keyword>
    <keyword id="KW-1015">Disulfide bond</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0645">Protease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <keyword id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="propeptide" id="PRO_0000412407" evidence="1">
        <location>
            <begin position="19"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000412408" description="Leucine aminopeptidase 1">
        <location>
            <begin position="91"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="357"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="324"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="390" mass="43225" checksum="9A7CFAA47E5C2BCB" modified="2005-04-26" version="1" precursor="true">MKLSTALVLGATATGAWSYAIPQLEQEVLELPETHYEQQEKYLIELSPYQTRWVTEEEKWALKLDGVNFIDITEDRNYGLFPTLDAGSYVNYPQKMGYVDTVKGLIAGLSMDNMRKDLENFTSFHTRYYKSSSGVESAQWLYDQVSKVVRDSGADKFGATVQKFDHSWGQFSIIARIPGLSKKTVVLGAHQDSINLFLPSFLGAPGADDDGSGTVTILEALRGLLKSDIVAHGQSPNTIEFHWYSAEEGGMLGSQAIFSKYKKNQADVKAMLQQDMTGYVQGTKHAGQKESIGVMTDFVDPALTSFLKNTIVTYCAIPFVETKCGYACSDHTSASKYGYPSAMATESTMENSNKHIHTTDDKISYLSFDHMLEHAKLTLGFAYELAFAAL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2010-04-20" modified="2025-04-09" version="99" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AYH4</accession>
    <accession>C8V1E3</accession>
    <name>PGLRD_EMENI</name>
    <protein>
        <recommendedName>
            <fullName>Probable endopolygalacturonase D</fullName>
            <shortName>PGD</shortName>
            <ecNumber>3.2.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Pectinase D</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Polygalacturonase D</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">pgaD</name>
        <name type="ORF">AN6656</name>
    </gene>
    <organism>
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in maceration and soft-rotting of plant tissue. Hydrolyzes the 1,4-alpha glycosidic bonds of de-esterified pectate in the smooth region of the plant cell wall.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>(1,4-alpha-D-galacturonosyl)n+m + H2O = (1,4-alpha-D-galacturonosyl)n + (1,4-alpha-D-galacturonosyl)m.</text>
            <dbReference type="EC" id="3.2.1.15"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.15"/>
    <dbReference type="EMBL" id="AACD01000110">
        <property type="protein sequence ID" value="EAA58185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF71186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_664260.1">
        <property type="nucleotide sequence ID" value="XM_659168.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AYH4"/>
    <dbReference type="SMR" id="Q5AYH4"/>
    <dbReference type="STRING" id="227321.Q5AYH4"/>
    <dbReference type="CAZy" id="GH28">
        <property type="family name" value="Glycoside Hydrolase Family 28"/>
    </dbReference>
    <dbReference type="GlyCosmos" id="Q5AYH4">
        <property type="glycosylation" value="5 sites, No reported glycans"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CBF71186">
        <property type="protein sequence ID" value="CBF71186"/>
        <property type="gene ID" value="ANIA_06656"/>
    </dbReference>
    <dbReference type="KEGG" id="ani:ANIA_06656"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN6656"/>
    <dbReference type="eggNOG" id="ENOG502QW1P">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040116_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AYH4"/>
    <dbReference type="OMA" id="SGDSCNY"/>
    <dbReference type="OrthoDB" id="1546079at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000002">
        <property type="entry name" value="Endopolygalacturonase D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050434">
        <property type="entry name" value="Glycosyl_hydrlase_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31884:SF9">
        <property type="entry name" value="ENDOPOLYGALACTURONASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31884">
        <property type="entry name" value="POLYGALACTURONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00502">
        <property type="entry name" value="POLYGALACTURONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword id="KW-1015">Disulfide bond</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0326">Glycosidase</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000393663" description="Probable endopolygalacturonase D">
        <location>
            <begin position="17"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="repeat" description="PbH1 1">
        <location>
            <begin position="280"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="repeat" description="PbH1 2">
        <location>
            <begin position="303"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="repeat" description="PbH1 3">
        <location>
            <begin position="342"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="repeat" description="PbH1 4">
        <location>
            <begin position="364"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="repeat" description="PbH1 5">
        <location>
            <begin position="393"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="repeat" description="PbH1 6">
        <location>
            <begin position="422"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="repeat" description="PbH1 7">
        <location>
            <begin position="456"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="134"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="312"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="136"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="356"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="378"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="240"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="322"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="366"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="429"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="490"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="173"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="358"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="483"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="506"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <sequence length="514" mass="52732" checksum="90FD05384EA55A6F" modified="2005-04-26" version="1" precursor="true">MKRCALLTPLLPLALACNNPNDPAHSCASIYSVSSDEAASFCATFTASVVSEPTGVPDAFLSACDSKIKHLSSACSCLGPVDSATATPVPATSTVPASVPVITTSTATATPSRIPVFVPSSSSSSAVVTFKTQIKSSSPGPSSSFAAAATTEAPTSTRASPYTPYTGNGGTTCTVTDYAGISSAVASCSNIMLSDVYAPPSSTIDLQDLQTGAAVIFAGKTTFGDTSDSDFDPIVISGTNLTITGTEDHVIDGNGQAYWDGQGSNGGSDKPDHFIVLKHVYNSVVANLNIQNWPVHCFDIENTESLTLTGITLDNSAGDEPNDSSDGDPAAHNSDGFDIKSSTDLILKDSNVYNQDDCVAITSGTNITVDNMYCSGGHGLSIGSIGGKSDNTVDGVVFSNSQVVNSQNGCRIKTNEGETGEVSNIKYENISLSGISKYGIVVQQDYLNGGPTGEPSNGVSITNVEFTDVTGTMSGGKDYYILCGDGSCENFTFSGVSITGGSDDSCNYPDSGCP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-08-16" modified="2026-01-28" version="100" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AZC0</accession>
    <accession>C8V0X9</accession>
    <name>ATG17_EMENI</name>
    <protein>
        <recommendedName>
            <fullName>Autophagy-related protein 17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">atg17</name>
        <name type="ORF">AN6360</name>
    </gene>
    <organism>
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Autophagy-specific protein that functions in response to autophagy-inducing signals as a scaffold to recruit other ATG proteins to organize pre-autophagosomal structure (PAS) formation. Modulates the timing and magnitude of the autophagy response, such as the size of the sequestering vesicles. Plays particularly a role in pexophagy and nucleophagy.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Preautophagosomal structure membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ATG17 family.</text>
    </comment>
    <comment type="sequence caution" evidence="3">
        <conflict type="erroneous gene model prediction">
            <sequence resource="EMBL-CDS" id="EAA58744" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EMBL" id="AACD01000107">
        <property type="protein sequence ID" value="EAA58744.1"/>
        <property type="status" value="ALT_SEQ"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF69627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AZC0"/>
    <dbReference type="SMR" id="Q5AZC0"/>
    <dbReference type="STRING" id="227321.Q5AZC0"/>
    <dbReference type="EnsemblFungi" id="CBF69627">
        <property type="protein sequence ID" value="CBF69627"/>
        <property type="gene ID" value="ANIA_06360"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AN6360"/>
    <dbReference type="eggNOG" id="ENOG502RYHP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028356_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AZC0"/>
    <dbReference type="OMA" id="THVWRAN"/>
    <dbReference type="OrthoDB" id="1937984at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990316">
        <property type="term" value="C:Atg1/ULK1 kinase complex"/>
        <property type="evidence" value="ECO:0000318"/>
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    </dbReference>
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        <property type="term" value="C:phagophore assembly site"/>
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    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0000318"/>
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    <dbReference type="GO" id="GO:0030295">
        <property type="term" value="F:protein kinase activator activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000425">
        <property type="term" value="P:pexophagy"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007240">
        <property type="entry name" value="Atg17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045326">
        <property type="entry name" value="ATG17-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28005">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28005:SF1">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04108">
        <property type="entry name" value="ATG17_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0072">Autophagy</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000124560" description="Autophagy-related protein 17">
        <location>
            <begin position="1"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="200"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="496"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="201"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="502"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="557" mass="60607" checksum="3CB1C8941515316B" modified="2011-11-16" version="2">MSAVDSSTSSGHPEREAQHETGLPPLETLISHLVAAKRSLSAINHVWRANEIVTSARSALEESVVVSARTGFLRSGLNNQLRLLYNVRAEVEEISLRGRSEFANALKSLDAADARLKKTLGLLRETIVHASFRPEGEEPKSLHDFVDERGVEELHSTLKSSIDRTNAAQADLDASNNAFDVELQSIKQALSTYRATTKLASSRGSVSSSGSQSGSSSSLPSISSMPSMVHSLEMHAQEMANLLESLVRHFDLCVTAVKHTEGGGAAAQSITGDMPAGVMGSHPGPGHGAGTGPTIEGDFNANPNAPLDPLSASEYREMVSVIVNDAAEAEDVVMEIQDRIGEMESVLETLTAQRDSFAAIYNATKEVFSYLSSLASTRLPGYIAQAHAFTAVWNDEHDRIKGGLADLSDLNALYDGFLDAYDGLIIEVARRRHVRHRVEKILRDARNKLDALYEEDVNARETFRVEQGDYLPSDIWPGLSREPMRVEFHRISGGPLKGVLQSPDQAQSPQPNEGEQLGHQDPQNPGDADSRFGEVIPDLPQELVEQALARLKSKRQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="123" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AZM4</accession>
    <accession>C8V1I7</accession>
    <name>Q5AZM4_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peptidyl prolyl cis-trans isomerase Cyclophilin, putative (AFU_orthologue AFUA_2G12990)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ANIA_06256</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF69842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_663860.1">
        <property type="nucleotide sequence ID" value="XM_658768.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AZM4"/>
    <dbReference type="STRING" id="227321.Q5AZM4"/>
    <dbReference type="GeneID" id="2871037"/>
    <dbReference type="KEGG" id="ani:ANIA_06256"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN6256"/>
    <dbReference type="eggNOG" id="KOG0111">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012062_27_1_1"/>
    <dbReference type="InParanoid" id="Q5AZM4"/>
    <dbReference type="OMA" id="YKPVWID"/>
    <dbReference type="OrthoDB" id="407442at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12347">
        <property type="entry name" value="RRM_PPIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034168">
        <property type="entry name" value="PPIE_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48037">
        <property type="entry name" value="ATPASE E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48037:SF1">
        <property type="entry name" value="RRM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="9"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="119"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="119"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBF69842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="153" mass="16737" checksum="0CDD4F22700E5855" modified="2005-04-26" version="1">MSEKTRLKCTVYVGGLDQAVSVQTLAEAFVPFGEVVDITLPKPDLPNSNDNHRGFGYVEFDSPEDAKEAIDNMDGSELYGRTIKVAPAKPQKDANEGLGSKTAIWEQEGYLSKYAVSEEDKLAAEESKMEDSGPSEDPIRRLEELDVAGPKPE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-07-27" modified="2026-01-28" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B011</accession>
    <accession>C8V2D9</accession>
    <name>ECM14_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Inactive metallocarboxypeptidase ecm14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">ecm14</name>
        <name type="ORF">AN6119</name>
    </gene>
    <organism>
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Inactive carboxypeptidase that may play a role in cell wall organization and biogenesis.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Vacuole</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the peptidase M14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks the conserved Glu residue in position 477 essential for carbopeptidase activity. The mature form lacks catalytic activity towards synthetic peptide substrates.</text>
    </comment>
    <comment type="sequence caution" evidence="7">
        <conflict type="erroneous gene model prediction">
            <sequence resource="EMBL-CDS" id="EAA58094" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EMBL" id="AACD01000104">
        <property type="protein sequence ID" value="EAA58094.1"/>
        <property type="status" value="ALT_SEQ"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF70147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B011"/>
    <dbReference type="SMR" id="Q5B011"/>
    <dbReference type="FunCoup" id="Q5B011">
        <property type="interactions" value="829"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5B011"/>
    <dbReference type="GlyCosmos" id="Q5B011">
        <property type="glycosylation" value="2 sites, No reported glycans"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CBF70147">
        <property type="protein sequence ID" value="CBF70147"/>
        <property type="gene ID" value="ANIA_06119"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2650">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019326_1_0_1"/>
    <dbReference type="InParanoid" id="Q5B011"/>
    <dbReference type="OMA" id="WFYHQLH"/>
    <dbReference type="OrthoDB" id="3626597at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03860">
        <property type="entry name" value="M14_CP_A-B_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000060">
        <property type="entry name" value="Putative metallocarboxypeptidase ecm14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057246">
        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705:SF147">
        <property type="entry name" value="INACTIVE METALLOCARBOXYPEPTIDASE ECM14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705">
        <property type="entry name" value="PROTEASE FAMILY M14 CARBOXYPEPTIDASE A,B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00765">
        <property type="entry name" value="CRBOXYPTASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00132">
        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword id="KW-1015">Disulfide bond</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <keyword id="KW-0926">Vacuole</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="propeptide" id="PRO_0000453243" evidence="3">
        <location>
            <begin position="22"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000411183" description="Inactive metallocarboxypeptidase ecm14">
        <location>
            <begin position="168"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M14" evidence="5">
        <location>
            <begin position="191"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="529"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="534"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="252"/>
            <end position="255"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="327"/>
            <end position="328"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="384"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="385"/>
            <end position="386"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="4">
        <location>
            <position position="337"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="4">
        <location>
            <position position="368"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="321"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P00730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="P15085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="3">
        <source>
            <dbReference type="UniProtKB" id="P38836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="4"/>
    <evidence type="ECO:0000255" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="7"/>
    <sequence length="586" mass="65977" checksum="82D4D92A60E180D8" modified="2011-07-27" version="2" precursor="true">MRSFRSLHLLLLAASAITADAVPAGSSITPPPPVEPVSLLSSHSNPQRPWTRLRNWVIESIWGIPKSQTSRPTAHDYSAPLQGSTRYGSDVVLRFRVQGLDEAEALTEATNILFLDVWASTTEFVDIRLAKEVIPSLLGLLPDSLQTAYVPLIDNLPEAISATYPARRSLGLNDQFMPSPSTRAPDLFFEDYQPLSVITPWMQLMASMFSSHARMINVGVSYEGRQIPALRLGRSSQPGESRPMILIVGGNHAREWISTSTVAYIAYNLMTRYGSSAAVTSLLQDYDWVLVPTVNPDGYVYTWDSDRLWRKNRQPTSFRFCPGIDLDRSWSFEWDGNQTQTNPCSENYAGEEPFEGVEAQQLAEWALNETEHNNARFVGFLDFHSYAQQILYPYTYSCSSVPPTLESLEELGLGLAKVIRLTTHEIYDVTSACEGVVIPASGDKSAKSLFPVGGSSGGSGLDWFYHQLRTRYAYQIKLRDRGSYGFLLPSEYIVPTGTEAFNAVLKLGQFLTEQDYPGIRNIDWESEYQVGDETPTQESTAFTDESHEEEGKDVTVDTDDEDDDYYDRWEPLKWEDQRPLGFRRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="124" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B0N9</accession>
    <accession>C8UZW1</accession>
    <name>Q5B0N9_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PHD finger and SET domain protein, putative (AFU_orthologue AFUA_2G11210)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ANIA_05891</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF70626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_663495.1">
        <property type="nucleotide sequence ID" value="XM_658403.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B0N9"/>
    <dbReference type="STRING" id="227321.Q5B0N9"/>
    <dbReference type="GeneID" id="2870703"/>
    <dbReference type="KEGG" id="ani:ANIA_05891"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN5891"/>
    <dbReference type="eggNOG" id="KOG1844">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009510_0_0_1"/>
    <dbReference type="InParanoid" id="Q5B0N9"/>
    <dbReference type="OMA" id="IKCICSF"/>
    <dbReference type="OrthoDB" id="1928087at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
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        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
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        <property type="entry name" value="Znf_FYVE_PHD"/>
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        <property type="entry name" value="FYVE/PHD zinc finger"/>
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    </dbReference>
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    <proteinExistence type="predicted"/>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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            <begin position="267"/>
            <end position="397"/>
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    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="98"/>
            <end position="180"/>
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    <feature type="region of interest" description="Disordered" evidence="2">
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            <begin position="760"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
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            <begin position="465"/>
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            <begin position="891"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CBF70626.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="903" mass="98157" checksum="A2A3BCDC9D1CB59A" modified="2005-04-26" version="1">MTETSPVVITHPTTEPFPVTAPLDSPIVNGAVSDSVPAEEEEPYTIKCICAFEDDDGNTVFCEGCETWQHIECYYHGRDVPEVHNCVDCEPRHLDSRRATERQRRLREQSDGGDRKAKRSGTKSHKKKAKDHADHVNGFHQRSESSSREQLPLKKAKTGHRASGSVNSLPGNSALTSDSRKRTAASLSPIKSFGPSIPLYSNEFLHLYDQDHGHADMDGNLFVNLTLAADLASWVKDHVSLAQVANGRSADEIFTRSGATLDRSHWPSLSLNSVTDPSTEFGGKHPTWKVLKTQDAVGKDEIVGEITGKIGLLRDYCLDPGNRWQELRHPEPFVFFHPQLPIYIDSRQEGSILRYARRSCRPNVTMKTYITNDVEYHFCFVAKEDIAPDSEITATWYLDPQLFGSTNGIVKQEPGDSVQEVAAVCISNVLANFGGCACVEPHSCLLSSLDCRRHPKLADGSVKQAHAKRRKTKSKPNVSPHGNNSRAGSEAVFTLDDDDHADSRSASSSNRGQTRSRDLTPTLQTPTDAFGFGDSELSARERRKIAAAEKKFQQLEQDQQTTHKRRKRVSGQSAHATGPGTSDRRSFSPPLSGGGHRSPRKPSALSTPARRYPYVDSAVQADIEVANGVMPSPPSSKRPNFVPLTQRLLKRCYIDRIRMEHTSRQQPDSPQSNKTTFEVSSHLVPTPTATTPSVSGEKEDVEMQDLESPTEASSARPQTRNPSMDMSPSHGRGSDGALPLPPPWPSSAAHIARIPARKVTSTRVDLHMPPTTATGLPSTASPNSISSAASSPSTLDPSSQHPGTALPGAGLAAPSPVKKKLSLGDYLSRRGSLKTPTSEKTQAQAAMPPPTPPAQLSDRRDVSAMTGNIHPDSSPSLSSPTTADVTMKHVSSSSQPAHSPSIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B162</accession>
    <accession>C8VFM2</accession>
    <name>Q5B162_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ANIA_05718</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF81341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_658230.1"/>
    </dbReference>
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        <property type="interactions" value="41"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5B162"/>
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    <dbReference type="KEGG" id="ani:ANIA_05718"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN5718"/>
    <dbReference type="eggNOG" id="ENOG502QPV0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026648_0_0_1"/>
    <dbReference type="InParanoid" id="Q5B162"/>
    <dbReference type="OMA" id="KQDRTTY"/>
    <dbReference type="OrthoDB" id="2011986at2759"/>
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        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018810">
        <property type="entry name" value="UPF0662"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28086:SF1">
        <property type="entry name" value="CU(2+) SUPPRESSING AND BLEOMYCIN SENSITIVE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28086">
        <property type="entry name" value="UPF0662 PROTEIN YPL260W"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DUF2408"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF81341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="440" mass="50400" checksum="E6125D923F381805" modified="2005-04-26" version="1">MESPAIQTPLDPKEQPILESVLRIRDALYLLKQDKSSYIRSRDVLPLYEEVTKEIEKLNAVRKDQNRRLAHNRLDYVLDDCFQLISLLFLTVGRNNEAPAVYSLAATVQRLLDHLEEAGFYSAKDLSSITTTLAGMRETLDRGKEAHSPALLTLLESRLDKCQIKLEKLQSELTKLSPELASTHETLVSVLRSTAAVNTRSKFSAAEVNGLRDQLKRIEDSMKDGNFVDANGNVLDNQEEVKLLLQRCWRWTEIVLEREGKIDERFREQYERLLDIRNQLDRLSVTQAWSLRETDLFVYQRKLDRIDEARVNGNFVDAEGKPADLHAQRTLLYLIRRSYAYIYALLISSEPVSEALLPVYNQLQTLRRCLLEVKESGGVSNSRELYPYSMKLNSIDNMRVDGKFYIGNDIPEGQGGVNALLAECYDLVWELRAAVADDKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B175</accession>
    <accession>C8VFN6</accession>
    <name>Q5B175_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Vacuolar protein sorting-associated protein 74</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ANIA_05705</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Phosphatidylinositol-4-phosphate-binding protein that links Golgi membranes to the cytoskeleton and may participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus. May also bind to the coatomer to regulate Golgi membrane trafficking. May play a role in anterograde transport from the Golgi to the plasma membrane and regulate secretion. Mediates the cis and medial Golgi localization of mannosyltransferases through direct binding of their cytosolic domains. Involved in vacuolar protein sorting.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">Golgi stack membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GOLPH3/VPS74 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF81367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_663309.1">
        <property type="nucleotide sequence ID" value="XM_658217.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B175"/>
    <dbReference type="FunCoup" id="Q5B175">
        <property type="interactions" value="536"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5B175"/>
    <dbReference type="GeneID" id="2871992"/>
    <dbReference type="KEGG" id="ani:ANIA_05705"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN5705"/>
    <dbReference type="eggNOG" id="KOG3983">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036311_1_1_1"/>
    <dbReference type="InParanoid" id="Q5B175"/>
    <dbReference type="OMA" id="GETWNLL"/>
    <dbReference type="OrthoDB" id="2189106at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031985">
        <property type="term" value="C:Golgi cisterna"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005797">
        <property type="term" value="C:Golgi medial cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019899">
        <property type="term" value="F:enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070273">
        <property type="term" value="F:phosphatidylinositol-4-phosphate binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048194">
        <property type="term" value="P:Golgi vesicle budding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035269">
        <property type="term" value="P:protein O-linked glycosylation via mannose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045053">
        <property type="term" value="P:protein retention in Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060304">
        <property type="term" value="P:regulation of phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3630.10:FF:000002">
        <property type="entry name" value="Vacuolar sorting-associated 74 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3630.10">
        <property type="entry name" value="yeast vps74-n-term truncation variant domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008628">
        <property type="entry name" value="GPP34-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038261">
        <property type="entry name" value="GPP34-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12704:SF2">
        <property type="entry name" value="GOLGI PHOSPHOPROTEIN 3 HOMOLOG SAURON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12704">
        <property type="entry name" value="TRANS-GOLGI PROTEIN GMX33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05719">
        <property type="entry name" value="GPP34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="27"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00058727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00073084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBF81367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="353" mass="39606" checksum="BE3CE8292F5ADD52" modified="2005-04-26" version="1">MASAGGLTRRRGGGRATGTDDHDDSRVSSPVSRNGSAMDNRIPETSYTNSENGHKIAFDPRDICETQERSKQPKLTLMEEVLLLGLKDKQGYLSFWNENISYALRGCIVIELALRGRVSMQKDSSRRRFPLADRVIEVIDDTLTGEVLLDEALKMMKSSEKMSVNSWIDLMSGETWNLMKIGYQLKQVRERLAKGLVDKGILRTEKRNFLLFDMATHPVADGGAKEDLNRRVRSICSSRTVILPANQWLPEDIEFRYLRTITMVCAAYAANVLENALVTMSHEARERAFAQVDELLAEYSQWPFARRPGGSQSIGANLAQAINDEVNKNSDKELQLEVVAACLSVFTRLDSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="122" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B1F1</accession>
    <accession>C8VFW9</accession>
    <name>Q5B1F1_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial</fullName>
            <ecNumber evidence="15">7.1.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">ANIA_05629</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="19">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="function">
        <text evidence="15">Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 15">
            <text>a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29091"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="7.1.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 15">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="14">Complex I is composed of about 40 different subunits. This is a component of the flavoprotein-sulfur (FP) fragment of the enzyme.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="15">Mitochondrion inner membrane</location>
            <topology evidence="15">Peripheral membrane protein</topology>
            <orientation evidence="15">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the complex I 51 kDa subunit family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.2" evidence="15"/>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF81519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_663233.1">
        <property type="nucleotide sequence ID" value="XM_658141.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B1F1"/>
    <dbReference type="STRING" id="227321.Q5B1F1"/>
    <dbReference type="GeneID" id="2871920"/>
    <dbReference type="KEGG" id="ani:ANIA_05629"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN5629"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
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        <property type="component" value="Chromosome V"/>
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        <property type="term" value="C:mitochondrial inner membrane"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="F:FMN binding"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="F:metal ion binding"/>
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        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
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        <property type="entry name" value="Mitochondrial NADH dehydrogenase flavoprotein 1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="NADH-ubiquinone oxidoreductase 51kDa subunit"/>
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        <property type="entry name" value="NADH-ubiquinone oxidoreductase 51kDa subunit, iron-sulphur binding domain"/>
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        <property type="entry name" value="ComplexI_51kDa_subunit"/>
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        <property type="entry name" value="NADH-UbQ_OxRdtase_51kDa_CS"/>
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        <property type="entry name" value="NADH-UbQ_OxRdtase_suF"/>
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        <property type="entry name" value="Nuo51_FMN-bd"/>
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        <property type="entry name" value="Nuo51_FMN-bd_sf"/>
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        <property type="entry name" value="Nuop51_4Fe4S-bd"/>
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        <property type="entry name" value="Nuop51_4Fe4S-bd_sf"/>
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        <property type="entry name" value="SLBB_dom"/>
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    <dbReference type="NCBIfam" id="TIGR01959">
        <property type="entry name" value="nuoF_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010120">
        <property type="entry name" value="PRK13596.1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] FLAVOPROTEIN 1, MITOCHONDRIAL"/>
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        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE FLAVOPROTEIN 1 NDUFV1"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF01512">
        <property type="entry name" value="Complex1_51K"/>
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    <dbReference type="Pfam" id="PF10589">
        <property type="entry name" value="NADH_4Fe-4S"/>
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        <property type="entry name" value="SLBB_2"/>
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        <property type="entry name" value="Nqo1 FMN-binding domain-like"/>
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    <dbReference type="SUPFAM" id="SSF142984">
        <property type="entry name" value="Nqo1 middle domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140490">
        <property type="entry name" value="Nqo1C-terminal domain-like"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00644">
        <property type="entry name" value="COMPLEX1_51K_1"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00645">
        <property type="entry name" value="COMPLEX1_51K_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 15" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="15" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6 15" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 15" id="KW-0288">FMN</keyword>
    <keyword evidence="10 15" id="KW-0408">Iron</keyword>
    <keyword evidence="11 15" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12 15" id="KW-0520">NAD</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="15" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="9" id="KW-1278">Translocase</keyword>
    <keyword evidence="15" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding" evidence="17">
        <location>
            <begin position="379"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="476"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003257"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007523"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00049551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00063883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU364066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CBF81519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="497" mass="54418" checksum="E281108AE5E08785" modified="2005-04-26" version="1">MISRAAAPSSTPLASLSSRSLRLQAPAARSFATVSDNAPPVHHHGGLKDQDRIFTNLYGHHGADLKSAMKYGDWYRTKDIVLKGHDWLISELKASGLRGRGGAGFPSGLKYSFMNFKDWDKDPRPRYLVVNADEGEPGTCKDREIMRKDPQKLIEGCLVVGRAMNANAAYIYIRGEFYHEATVLQQAINEAYQAGLIGKNACGTGYDFDVFIHRGMGAYVCGEETSLIESLEGKAGKPRLKPPFPAAVGLFGCPSTVTNVETVAVTPTIMRRGASWFAGFGRERNAGTKLFCISGHVNNPCTVEEEMSIPLRELIDRHCGGVRGGWDNLKAVIPGGSSTPIIPKSVCDDQLMDFDALKDSQTGLGTAAVIVMDKSTDVVRAISRLSTFYKHESCGQCTPCREGSKWTLQMMQRLEKGQAREREIDMLQELTKQVEGHTICALGEAFAWPIQGLIRHFRPELEARIKEYSEGLGGQQPLAGGWHPNSRAEGKLISPGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="112" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B1H2</accession>
    <accession>C8VFZ1</accession>
    <name>Q5B1H2_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ANIA_05608</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF81560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_663212.1">
        <property type="nucleotide sequence ID" value="XM_658120.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B1H2"/>
    <dbReference type="STRING" id="227321.Q5B1H2"/>
    <dbReference type="ESTHER" id="emeni-q5b1h2">
        <property type="family name" value="Fungal_carboxylesterase_lipase"/>
    </dbReference>
    <dbReference type="MEROPS" id="S09.A99"/>
    <dbReference type="GeneID" id="2871901"/>
    <dbReference type="KEGG" id="ani:ANIA_05608"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN5608"/>
    <dbReference type="eggNOG" id="KOG1516">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006586_17_1_1"/>
    <dbReference type="InParanoid" id="Q5B1H2"/>
    <dbReference type="OMA" id="WNYSIMH"/>
    <dbReference type="OrthoDB" id="6846267at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142:SF8">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="18"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBF81560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="541" mass="61449" checksum="83C70A86456DCD8F" modified="2005-04-26" version="1">MGSNISYQCSDCEVQLPGAKGKIKGLQFDNKSRRFANIPYSLPPTGERRWRKPQALPESYSYSRPEGGPFDGTKFGQVCLQPNYSASVKKNIPQHEYGEDCLRLNIWTPVPKDGEPTPAKWPVMIWFHGGWFQMGDPSNEPSMDPTEMISTGGLNAVFVAVGYRLNLFGFLAGVPLRDESPDGAVGNYGLWDQRLAIDWVYENISAFGGDPRNITLSGRSAGAYAVQAQILYDFRGNLPESSRNRFRRLVMYSNAIPAQPKTPDECQPQFDELCEYFKIPSASSGREKLRRLREINANDLCGAIMKLKHHTFRPVTDCVFIHPDLFKYYRDGSFAREFKRRGLRILIGEVLNEETLYAVTNGPEANFESLEAQVSNYYSPATTRRLLQYYTLPTSTEKKDWEAVFGRIISDGQVRAPSRFLVNNLIENGVNISDVWRYMIAYRFSFITEKVAPTSFGVSHAMDRPFHNYSLMHGPTPAERQFMHAWIRDLVAFVNHESDYVYGTEQVDEVKVATPQGRIEIQKDSRWAELLSLMAVFAGYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B202</accession>
    <accession>C8VGJ3</accession>
    <name>Q5B202_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Microbody (Peroxisome) proliferation protein peroxin 11B (Eurofung)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ANIA_05428</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Peroxisome membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF81925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_663032.1">
        <property type="nucleotide sequence ID" value="XM_657940.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B202"/>
    <dbReference type="GeneID" id="2871716"/>
    <dbReference type="KEGG" id="ani:ANIA_05428"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN5428"/>
    <dbReference type="eggNOG" id="ENOG502SS81">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049216_1_1_1"/>
    <dbReference type="InParanoid" id="Q5B202"/>
    <dbReference type="OMA" id="MFFTTFT"/>
    <dbReference type="OrthoDB" id="3636394at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008733">
        <property type="entry name" value="PEX11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12652:SF23">
        <property type="entry name" value="MICROBODY (PEROXISOME) PROLIFERATION PROTEIN PEROXIN 11B (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12652">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05648">
        <property type="entry name" value="PEX11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="1" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="161"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00046271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBF81925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="237" mass="26183" checksum="532B4C5421608B4E" modified="2005-04-26" version="1">MAQTPASSGFSPLKSLVIYTSQTSGLEKTLRLIQATSQVVGVTTASKALATQCLTARDQLALTRRYFRLLDFYGCFERVHFLINTPSSTGTILSVMELAQYTFLGLYLLLEDLTILHDMGVARVDWYHPLMTEANKFWFYALMLSVIRCTWELFFPSAPVTPSKTSSSGSEKSKARGQQPQPSPPKWPLVKRIIIDGCDLTLPGSFLGWTPVTSLQIGLGMVLSTVLAGHDVWAAQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="143" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B2N6</accession>
    <accession>C8VF68</accession>
    <name>Q5B2N6_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">ABC transporter (Eurofung)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">ANIA_05194</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="16">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF81056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_662798.1">
        <property type="nucleotide sequence ID" value="XM_657706.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B2N6"/>
    <dbReference type="FunCoup" id="Q5B2N6">
        <property type="interactions" value="316"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5B2N6"/>
    <dbReference type="GeneID" id="2871486"/>
    <dbReference type="KEGG" id="ani:ANIA_05194"/>
    <dbReference type="eggNOG" id="KOG0061">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_57_1_1"/>
    <dbReference type="InParanoid" id="Q5B2N6"/>
    <dbReference type="OMA" id="FNCQLDA"/>
    <dbReference type="OrthoDB" id="66620at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042626">
        <property type="term" value="F:ATPase-coupled transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd03213">
        <property type="entry name" value="ABCG_EPDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000702">
        <property type="entry name" value="ABC transporter (Adp1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050352">
        <property type="entry name" value="ABCG_transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041:SF2">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="708"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="743"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="798"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="824"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="851"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="937"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="14">
        <location>
            <begin position="242"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="504"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="531"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="555"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="566"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="597"/>
            <end position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CBF81056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="963" mass="106534" checksum="0BA0A989CF8DA11D" modified="2005-04-26" version="1">MPTGEDGVCYKQGVTVKENFQMCDVTNRKILDQLKERKPQVTFSCEAEDKTCNFQFWVDQVESFYCGLDTCDWGLETDYDKNTTHYKCENINCKCIPGRMLCGEEGSIDIGEFLKQSIKGPATFSSVSTVGGSKEDGSKFQEPEMDNLIKSVFGDESITLKCSSGECVHKTEVPGYQRPVKKINTPLIAGVIAGCALFVVAVILGLWYQSRRSRYSRIQLSLSDDSDDEASKLLADHRPAALYWDNVSYFVNGKEILSGIQGVAQPGQITAIMGASGAGKTTFLDLLARKNKRGIAQGDFYVNGEKLDDADFKSMIGFVDQEDTMLPTLTVHETILTSALLRLPRDMSRAAKEQRVTEVEKQLGIHHIKDQLIGSEEGSGRGISGGEKRRVGIACELVTSPSILFLDEPTSGLDAFNAFNVVECLVSLAKDYNRTVIFTIHQPRSNIVALFDRLILLANGKTVYSGPFSTCQQYFDDAGYTCPPGFNIADYLVDLTMHAGSTTQFHSDEEESPLLAVRSDPPKTASSSLRAVKSVASASNASIEDSSNSFDYGRRPKGKRRTSLKQRQDRQLYSRRKDADAPPTPRTDEEDAAEVGESQQHWLRLSRQQGQTPPQILDDPHDLPPAASGQTDLDLMVAHYAASDIARNVRNEIISATQRASAGNGSVNSEVPSSPLVQTPKSYARVSLARQFIILSQRTWRNLHRNPMLMLTHYAIAILLAVLCGFLFYGLTDDIKGFQNRLGLFFFVLALFGFSTLTSLTVFSTERLLFVRERANGYYHPVTYYAAKVVFDIVPLRLIPPIIMGVIVYPMTGLIPAWPEFFKFILVLVLFNLAAATICLFIGIVFRDGGVANLIGSLVMLFSLLFAGLLLNHDAIPPSALWLQSLSIFHYGFEALIVNEVTFLTLIDHKYGLDIEVPGASILSAFGFDTLAYWKDVIGLAVFSGAFLVIAYIAMHFLLVERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B3E9</accession>
    <accession>C8V9D4</accession>
    <name>Q5B3E9_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CSN8/PSMD8/EIF3K domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_04931</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF76451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_662535.1">
        <property type="nucleotide sequence ID" value="XM_657443.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B3E9"/>
    <dbReference type="STRING" id="227321.Q5B3E9"/>
    <dbReference type="GeneID" id="2872726"/>
    <dbReference type="KEGG" id="ani:ANIA_04931"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN4931"/>
    <dbReference type="eggNOG" id="ENOG502RXZN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055649_0_0_1"/>
    <dbReference type="InParanoid" id="Q5B3E9"/>
    <dbReference type="OMA" id="WTWEKLV"/>
    <dbReference type="OrthoDB" id="2100128at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39398:SF1">
        <property type="entry name" value="CSN8_PSMD8_EIF3K DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39398">
        <property type="entry name" value="YALI0F14311P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF76451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="323" mass="36557" checksum="D3E68DCA28929DD7" modified="2005-04-26" version="1">MSGRAPSAKWPHSRLKPVADSLESVGFVSKGDCKLLDHKAQKNYYDKIMARYIEFCARHSKNLDEAWLSLPRSASNDATKNPPASVPQSTKSAVSPGPSPATELSTLLLSLRKLREAVLATASTTPISFSQRVHVFSIKVSIQARHPPSYFPSLRHLLDDLHTPSNPLPDSELKDHTSYLILDYACRQEDLVAAFELRARARRQYNFHSREVDQILQAIAHDNWIVFWRVRKEVDSAMRAIMNWAEDRVRRHALKAVGKAYLGVDIAWIVEGCTGDSTWTWEKLAEREKLGWEKEGDRVIIRKPRSKPKPEGNLTPIQEKSTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="118" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B4C7</accession>
    <accession>C8V7T6</accession>
    <name>Q5B4C7_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">allantoinase</fullName>
            <ecNumber evidence="6">3.5.2.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ANIA_04603</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(S)-allantoin + H2O = allantoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17029"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15678"/>
            <dbReference type="ChEBI" id="CHEBI:17536"/>
            <dbReference type="EC" id="3.5.2.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Nitrogen metabolism; (S)-allantoin degradation; allantoate from (S)-allantoin: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the metallo-dependent hydrolases superfamily. Allantoinase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.5" evidence="6"/>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF77167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_662207.1">
        <property type="nucleotide sequence ID" value="XM_657115.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B4C7"/>
    <dbReference type="FunCoup" id="Q5B4C7">
        <property type="interactions" value="1240"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5B4C7"/>
    <dbReference type="GeneID" id="2872401"/>
    <dbReference type="KEGG" id="ani:ANIA_04603"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN4603"/>
    <dbReference type="eggNOG" id="KOG2584">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015572_4_0_1"/>
    <dbReference type="InParanoid" id="Q5B4C7"/>
    <dbReference type="OMA" id="SRLHVCH"/>
    <dbReference type="OrthoDB" id="10258955at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004038">
        <property type="term" value="F:allantoinase activity"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009442">
        <property type="term" value="P:allantoin assimilation pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006145">
        <property type="term" value="P:purine nucleobase catabolic process"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000032">
        <property type="entry name" value="Allantoinase Dal1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050138">
        <property type="entry name" value="DHOase/Allantoinase_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002195">
        <property type="entry name" value="Dihydroorotase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43668">
        <property type="entry name" value="ALLANTOINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43668:SF2">
        <property type="entry name" value="ALLANTOINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00482">
        <property type="entry name" value="DIHYDROOROTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="10">
        <location>
            <begin position="62"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CBF77167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="506" mass="54732" checksum="AA9DCFA41EE568D9" modified="2005-04-26" version="1">MNGEIPSIAVFTSSRAVIGGRLTSATIVVSRTTGKVTAVFDSVIPASDFPDGTPYTDFSPYVLLPGLVDAHVHLNEPGRTEWEGFYTGTQAAAFGGVTTVIDMPLNAIPPTTTVENFKLKLKAAEGKCWVDVGFYGGIIPGNAGELKALVREGVRGFKGFLIDSGVDEFPAVSSEDVRKAMAELADEPTTLMFHAEMVPPKTPSELPEVMPEGAPEAYSTFLASRPSEYELCAVEEILSLSHLAPKLPLHIVHLSAMEAIPLLRKARAEGVPITAETCYHYLSLAAEEIRDGDTRHKCCPPIRSKSNQDALWAELDRHAEDGVIKTIVSDHSPCTPDLKLLPSHIPGNCSHGSSKHANTTPVVNEGSFLSAWGGISSVGLGLPILWTELSRRKGLTSSPDDTTTKQALQDIVHLCCANTAAQVGLHKSKGDLVPGYDADFCVFDDTAEWEVEPSTMLFRNKCSPYQGRTMRGMVRETWLRGEKIFNRDDGFTVKAPSGSLLLEKRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="107" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B4E9</accession>
    <accession>C8V7V9</accession>
    <name>Q5B4E9_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nuclear protein (Sgd1), putative (AFU_orthologue AFUA_2G01980)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ANIA_04581</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CWC22 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF77213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_662185.1">
        <property type="nucleotide sequence ID" value="XM_657093.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B4E9"/>
    <dbReference type="FunCoup" id="Q5B4E9">
        <property type="interactions" value="618"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5B4E9"/>
    <dbReference type="GeneID" id="2872380"/>
    <dbReference type="KEGG" id="ani:ANIA_04581"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN4581"/>
    <dbReference type="eggNOG" id="KOG2141">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006786_2_1_1"/>
    <dbReference type="InParanoid" id="Q5B4E9"/>
    <dbReference type="OMA" id="FMVDILN"/>
    <dbReference type="OrthoDB" id="361797at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000050">
        <property type="entry name" value="Nuclear protein (Sgd1), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050781">
        <property type="entry name" value="CWC22_splicing_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003891">
        <property type="entry name" value="Initiation_fac_eIF4g_MI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18034">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN CWF22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18034:SF4">
        <property type="entry name" value="NUCLEOLAR MIF4G DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02847">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00544">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00543">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51366">
        <property type="entry name" value="MI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MI" evidence="5">
        <location>
            <begin position="597"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="192"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="15"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="36"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="66"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="105"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="216"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="276"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBF77213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="844" mass="94723" checksum="1927094990F47678" modified="2005-04-26" version="1">MPRPRHNTTSLPRGLRQELGIRDRYGERKNKRIERSRKDLRREERAENKRGGPGSKKSANSRHRDDEDDDNDFDDLGDGSDFDGDSGESDEDDGDVMAKLKAAKQKMEKPSASSRKVEDDALRDVPRKEVSKAVQDQLDQDDAEIAALEKKLGLKKGKLPKSFAEDGLDELLGDLGGGSADEDRKRKREADEWLLNKRRKAQGMPVEESEASGSDDMSDEDLESLPDDEDIDGFDEEDGEDESEDDQPAPKKRENPYVAPVVATTEDKPGKYIPPSLRAASSSESESLTRLRRQAQGHLNKLSEANLVSILAEFEKLYREYPRQNVTSTLVTLLFGLICERSALQDTFIILHAGFIAAVYKVMGMDFGAEIVQKIVETFDAGGDDRGKFEGKEMINLISLLSQLYNFHVVGSTLVFDYIRLFLQDINEDNTELLLKVIRNSGPQLRQDDPSSLKDIVLLIQPAVTKAGTASLSVRTKFMIDTITDLKNNRLKSAANSTIASEHITKMRKILGSLNNSRVIRATEPISISRSDIHNSSKKGKWWLVGASWKEDPLESARQELSSLSAANTHQATIVADDSEAEPDYASIAKAHRMNTDVRRSIFVAIMSATDFQDAHVRLLKLRLKRAQEFEIPRVLTHCAMEEDAHNPYYTLIARRLCGELGRRIKMSFMFTLWNIFKRMGESGDMDDDEEDGSNLHGEDEENPLSMKSVVNLAKMYASLIADGTLTLGILKTLNFAYLQPKTKAFVEVLMISIIQQSQKQKKNKKSKSKSKSEDSLDEQPLVEIFMKTEYTPQIIKGCIFFLRKVVAKTDIVASEKEAVMVKWGVRVAVDALKVVESKESKFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="141" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B4I0</accession>
    <accession>C8V877</accession>
    <name>Q5B4I0_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Aspartate--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="3">6.1.1.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Aspartyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">ANIA_04550</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="16">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>tRNA(Asp) + L-aspartate + ATP = L-aspartyl-tRNA(Asp) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19649"/>
            <dbReference type="Rhea" id="RHEA-COMP:9660"/>
            <dbReference type="Rhea" id="RHEA-COMP:9678"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.12" evidence="3"/>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF77275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_662154.1">
        <property type="nucleotide sequence ID" value="XM_657062.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B4I0"/>
    <dbReference type="FunCoup" id="Q5B4I0">
        <property type="interactions" value="1204"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5B4I0"/>
    <dbReference type="GeneID" id="2872350"/>
    <dbReference type="KEGG" id="ani:ANIA_04550"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN4550"/>
    <dbReference type="eggNOG" id="KOG0556">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004553_2_1_1"/>
    <dbReference type="InParanoid" id="Q5B4I0"/>
    <dbReference type="OMA" id="WVHEIRD"/>
    <dbReference type="OrthoDB" id="372395at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004815">
        <property type="term" value="F:aspartate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990825">
        <property type="term" value="F:sequence-specific mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006422">
        <property type="term" value="P:aspartyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd04320">
        <property type="entry name" value="AspRS_cyto_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00776">
        <property type="entry name" value="AsxRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000132">
        <property type="entry name" value="Aspartyl-tRNA synthetase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000124">
        <property type="entry name" value="Putative aspartyl-tRNA synthetase Dps1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02075">
        <property type="entry name" value="Asp_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004523">
        <property type="entry name" value="Asp-tRNA_synthase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00458">
        <property type="entry name" value="aspS_nondisc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003483">
        <property type="entry name" value="PRK05159.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43450:SF1">
        <property type="entry name" value="ASPARTATE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43450">
        <property type="entry name" value="ASPARTYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="14">
        <location>
            <begin position="243"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="36"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="48"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CBF77275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="555" mass="61507" checksum="97643F53D9722215" modified="2005-04-26" version="1">MADSELPARPKPEETPAAEAGEGGEGKLSKSALKKLAKDKAKAEKAAQRAAQEKAQAAAAEANDTAKDLYGPIPETADVLPSTQLSQINDEHYEKEVTVVARVDNARAQSAKLAFLMLRQQGLKVQAVIAAAEPISRQMVKYTSGLNVNSIVQVTGIVKKPGVPIASATLSNHEIHIRKVYMIAEAAQQLPMQVKDAERPLPETTEEGFQVDSDGAPIVTLKTRLDNRVLDLQTATSQAITWISSGVAELFAEYMIKSGSRWISTPKLVGAATEGGSGVFEVKYFKRNAYLAQSPQLYKQMCIAGDMQSVFEIAPVFRAEESNTHRHLTEFTGLDFEKTFSSHYHEVLEFAEQLLVFILSQLKERYADQIAIIQKSYPKAGDFKLPKDGKALRLNYMDGVALLKEAGVDVSEQERFENDFTTAMEKQLGQIIREKYDTDFYVLDKFPMAVRPFYTKACPQDPRFSNSYDFFMRGEEIMSGAQRIHDVKELEASMIAKGVNPNQEGFEDYLAAFRQGCPPHAGGGLGLNRIVMFFLGLPNIRLATLFPRDPQRLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B569</accession>
    <accession>C8V983</accession>
    <name>Q5B569_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ANIA_04311</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF77790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_661915.1">
        <property type="nucleotide sequence ID" value="XM_656823.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B569"/>
    <dbReference type="STRING" id="227321.Q5B569"/>
    <dbReference type="GeneID" id="2872111"/>
    <dbReference type="KEGG" id="ani:ANIA_04311"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN4311"/>
    <dbReference type="eggNOG" id="ENOG502S35T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042190_1_0_1"/>
    <dbReference type="InParanoid" id="Q5B569"/>
    <dbReference type="OMA" id="IENPGVY"/>
    <dbReference type="OrthoDB" id="5411678at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549:SF30">
        <property type="entry name" value="MID2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="270"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="10"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="275"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="330"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBF77790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="413" mass="42178" checksum="FC65D2BAD2D03356" modified="2005-04-26" version="1">MSQSVPNPAPSTTVDTEPSPTTTSDTDSTETSQTSTSTSTESEPSSTAETSTSTTESPTSTSTSETTEPTVTSTSSETSSAPTSTTSSSTTTTTTDDPTTTTTETTSTTTEPTSSDTVEPTATTTEITTGTTTTTITITGTPTGPTTTGSGDASSTIDSSSAASATETGGSDSGLSAGGTIAVAVVVPVVSVAILVLVGLWLWRRHKAKKVAEEERRKEVEEYGFNPNGDPTLPAVIGGSADDNAGYRGWGTTSAGRKASTNISSSAGVGLAMSEASSQPGYHHTATPSDGTIQYEGHGPLGETEPYGILGAAPVTAATSNQRHTDINRGPSNASSAYSAGNHSDISEESNMSANHPGGPYYDYADVQQQYGGYNDPYGAQPVIRDVQARRNTQIQNPSVFPRQGNAGIAQNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="100" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B5G4</accession>
    <accession>C8V4B6</accession>
    <name>Q5B5G4_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha-L-rhamnosidase B, putative (AFU_orthologue AFUA_1G06130)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ANIA_04216</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CBF74463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_656728.2"/>
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        <property type="interactions" value="142"/>
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    <dbReference type="STRING" id="227321.Q5B5G4"/>
    <dbReference type="GeneID" id="2873637"/>
    <dbReference type="KEGG" id="ani:ANIA_04216"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN4216"/>
    <dbReference type="eggNOG" id="ENOG502RZJ2">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="OMA" id="FMHLRDG"/>
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        <property type="component" value="Chromosome II"/>
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    <dbReference type="GO" id="GO:0016872">
        <property type="term" value="F:intramolecular lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="Gene3D" id="3.50.70.10">
        <property type="match status" value="1"/>
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        <property type="entry name" value="Chalcone_isomerase_sf"/>
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        <property type="entry name" value="FATTY-ACID-BINDING PROTEIN 2"/>
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        <property type="entry name" value="FATTY-ACID-BINDING PROTEIN 2"/>
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    <dbReference type="SUPFAM" id="SSF54626">
        <property type="entry name" value="Chalcone isomerase"/>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="Chalcone isomerase" evidence="3">
        <location>
            <begin position="183"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBF74463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="437" mass="47917" checksum="771D0797E46CCA82" modified="2005-04-26" version="1">MAFKPPLSVSKSILFRNCGQCIRNRYLRPTATSRYLSTSSPLRNNPLRARANANSREEDVAKYRRSMIVSGAGILACGMAMYGVIKLDLFGLELQQQQKAQEAAEKKKNNGTMRMDGPDGFTSSPSVIRIQGQDGVEQVTTGTSSVPYFPSTIRLPKYEGDGSSAASKLAPWDELTGNGEDEEEYQLLGLGVRTVSFLKIQVYVVGLYVAKSDISELQQRLVHMAAHPPSDQEVITNQVGATSATSLVSTERQRLKDLLLDGEKGEDAWNAILKEDGLRTAIRIVPTRNTDFAHLRDSWVRGITTRAQKANARAKAAATEAGAGAANPDEFQDDVFGSAVNDFKTLFGGGQRKHVPKGQTLLLLRNARGELDALFQPDASKPFRFMGRVSDERISRLVWLIYLGGKNVSSEEARRNIVDGIMGIVERPIGTVVQKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="110" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B5G9</accession>
    <accession>C8V4C1</accession>
    <name>Q5B5G9_EMENI</name>
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        <submittedName>
            <fullName evidence="11">LMBR1 domain protein (AFU_orthologue AFUA_1G06071)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ANIA_04211</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LIMR family.</text>
    </comment>
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        <property type="protein sequence ID" value="CBF74473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="XP_661815.1">
        <property type="nucleotide sequence ID" value="XM_656723.2"/>
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    <dbReference type="AlphaFoldDB" id="Q5B5G9"/>
    <dbReference type="STRING" id="227321.Q5B5G9"/>
    <dbReference type="GeneID" id="2873633"/>
    <dbReference type="KEGG" id="ani:ANIA_04211"/>
    <dbReference type="eggNOG" id="KOG2296">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010501_0_0_1"/>
    <dbReference type="InParanoid" id="Q5B5G9"/>
    <dbReference type="OMA" id="WISEYLR"/>
    <dbReference type="OrthoDB" id="203099at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
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        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="entry name" value="BAG domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
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        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR21355:SF0">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR-ASSOCIATED PROTEIN LMBRD2"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="LMBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63491">
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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            <begin position="133"/>
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    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="162"/>
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    <feature type="transmembrane region" description="Helical" evidence="8">
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    <feature type="transmembrane region" description="Helical" evidence="8">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="447"/>
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    <feature type="transmembrane region" description="Helical" evidence="8">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="798"/>
            <end position="816"/>
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    <feature type="domain" description="Ubiquitin-like" evidence="9">
        <location>
            <begin position="888"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="domain" description="BAG" evidence="10">
        <location>
            <begin position="1080"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="565"/>
            <end position="603"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="676"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="942"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="214"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="581"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="964"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="982"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1004"/>
            <end position="1019"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010487"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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        <source>
            <dbReference type="SAM" id="Coils"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51035"/>
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    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CBF74473.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="1124" mass="125388" checksum="A7F3306F755DD67A" modified="2005-04-26" version="1">MITIASISVGSSIFFTLALLIISVLVLLLLRRFLTLRATPAYLSIPVFLALALPASVVLLVPIDLASSSRDKGDRPNAIWLPERLLLVSWRIAYWLIFVLTWAILPLLGEYIDSGHRDGKARIQYSVRSNARYQMIVLGCATVGLIYISIQNGFEFSTIKALAMALAYVWGLVLAIYLMGHGLVSIPRTLFRNASASGRLRRLQSHAPLMHDRLMDAINDLETLEAQVSQLQSRKTGTARDFQDWIDELAETSTPPELRSGLLEPASSPSTVPAVITERYLADLTRRLQRARHQKARFVDAWDRLIYTAADLQAIINSSASKKLEFTHQSQRSACLAQSKFLTPYMRYQLYTNVYPNLRLAFGALFAAASVCVVWSELIKSIAPRLSVVTMSIVSYHERPAPVGFGRQVIASMWLMYMCSAALVGVNDAKVWGNRALVRRNTYGESACWYASLVARLTVPIAYNFLTFLPKNVRESTTFYRFLGQWIDLTPLGKGFDYFFPVAILIPIGATMFNLYGRVRNICGFGLIEEDDDDLENNPSGYGIGGWREGRELIERELSGLGSLGLSARNERSPRRPINADGNTQAYSSSRTPLTDASRPSRSIRSAVASTSVVQEEDEDENFFQSFAHRVRNTIETAGRPQWLQNDSFRLPRWMSNDGNDGNNGLARWFGGRPANGGKSKYMQNKHDTSRPKSPSELSRHDAYGGMSASTIRWEYSPIASTCQVFRWMGFCCTSLGETCAFYLDYITASLPPSLHSLHHKFLLPLISRPALPSTPLLRALSSPSDWASYYSTDYNKLSAALTLVTCAIALVVMSWRNLWRRPAPPHQSTNTGERPYTYLTPDDIVDPPSRLYKEEDDSEPDKLILNHRKVTYELHFPPYSINDGTLSIGQLRQAAAEVTRTADPNRIKLLYKGKLLDDDSLPCRAEGLKQQSEILCVVSEVQSGTRTPSDVSSIGRTSEETPRLSSLNISEITPRSDGSKKNKRKKKNKGKKKSKADSDDNESSTPAQRPQPTSSSDGGSRYALPPPAPNLNTFPTPLGQVQGLTAYFRKEIVPLCNRYITDPPQDEKTRDFEHKKLGETILAQVMIKADSIEVVDDETRSARRALIKEAQSTLNQVDAVAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B5P8</accession>
    <accession>C8V4Z8</accession>
    <name>Q5B5P8_EMENI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_04132</name>
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        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
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    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF74634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_656644.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="2873555"/>
    <dbReference type="KEGG" id="ani:ANIA_04132"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN4132"/>
    <dbReference type="HOGENOM" id="CLU_808992_0_0_1"/>
    <dbReference type="InParanoid" id="Q5B5P8"/>
    <dbReference type="OrthoDB" id="10683139at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="307"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="202"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF74634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="343" mass="37608" checksum="C9F873526AAC5E93" modified="2005-04-26" version="1">MVKAELIRRTNKKLDNRVADVLPNIQTPTECTAQVEYRFAAKRQRKADTHKFSDAQMPVRCAAHQASEIQGGISELGYQRDSPENTEGGNCSHIEHYGSCGNGCDGDAGNTKLTTKPHKKVSWNLTGNISAPLQSSVAPLLPAQHLQSAAVPDTLPQQDLSTSSKPLSALEMAESAIFVQKTNFVALGDTPIGCHEQPQTDTSRLSVTSSGSRSQEEFVTPTVSENTLKEHHERIQELPTVFPAQQDADLGEGKINDMEDLASTDADPNARIQELEDCVVAQALKLVSQAKEIKSLVETVNELRGTIQSSSGKGYRPCKRSKEYTDEKIFEPQKDENRDPRLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="111" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B624</accession>
    <accession>C8V5R1</accession>
    <name>Q5B624_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">GMC oxidoreductase (Eurofung)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ANIA_04006</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the GMC oxidoreductase family.</text>
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    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF74901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_656518.1"/>
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    <dbReference type="CAZy" id="AA3">
        <property type="family name" value="Auxiliary Activities 3"/>
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    <dbReference type="KEGG" id="ani:ANIA_04006"/>
    <dbReference type="eggNOG" id="KOG1238">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_002865_6_1_1"/>
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        <property type="component" value="Chromosome II"/>
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        <property type="term" value="P:secondary metabolite biosynthetic process"/>
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        <property type="entry name" value="Glucose Oxidase, domain 3"/>
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        <property type="entry name" value="GMC_OxRtase_C"/>
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        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
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        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="GMC_oxred_N"/>
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        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
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    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030175773" evidence="5">
        <location>
            <begin position="25"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="6">
        <location>
            <begin position="112"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="7">
        <location>
            <begin position="304"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="549"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="592"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="122"/>
            <end position="125"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
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    <feature type="binding site" evidence="3">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBF74901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="610" mass="65701" checksum="2B1FF28F4EAA6857" modified="2005-04-26" version="1">MHLTWATGIAGLAIWLGRIPPGQTLATESRLLATYDYVIVGAGVSGLTVANRLSENKKLSVLIIEAGGFDEDEDFILVPGLAGNAIGTKYDWNLTYAVNPDLGNRTVSIPQGKAVGGSSLLNRMVFDRGSKADYDRWEALGNPGWGWRDLFPFFKKSENFTPPSEDVIDEWNATYDPAVHGTTGNVQSSYAPWIWPSTKQFISAITSLGVHVPRDGASGDALGGFFVPHSQDAISVTRSDARRAYWDAVSKRPNVHLLTGQRVTRMISKRTSRRVQITGVEFAAHRSGARTIVNARKEVLLAAGAIHTPQLLQLSGIGDRATLNRHNISTVADVPGVGRNLQDHLHVPVVFSFDFPLTATNLTTNSTFAAESWALYRTHKTGPYADATGDFLAFFPTVNFTSQADVLQGIAADQNPQAYLDKDTPPSIVDGYAVQHKLLTSGLAATDEAQLEIIWADGTFVLGLQHPFSRGSVRLASSDPFAQPLADPAYLRNPVDVRILIEAIKYARSLTTTLSLAAFNPVELVPGGSITSDEDLEAYVRGAVDSLFHPSGTCAVGKFELGGVVDVDFKVHGVKGLRVVDASVLPMLPATHIQSSVYAVAEKAAKAILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B658</accession>
    <accession>C8V5X4</accession>
    <name>Q5B658_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">5-oxo-L-prolinase, putative (AFU_orthologue AFUA_6G14330)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ANIA_03972</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxoprolinase family.</text>
    </comment>
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        <property type="protein sequence ID" value="CBF74975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_656484.1"/>
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        <property type="interactions" value="834"/>
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    <dbReference type="KEGG" id="ani:ANIA_03972"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN3972"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002157_0_0_1"/>
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    <dbReference type="OMA" id="RREFNFN"/>
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        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017168">
        <property type="term" value="F:5-oxoprolinase (ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049517">
        <property type="entry name" value="ACX-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008040">
        <property type="entry name" value="Hydant_A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002821">
        <property type="entry name" value="Hydantoinase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003692">
        <property type="entry name" value="Hydantoinase_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045079">
        <property type="entry name" value="Oxoprolinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365:SF2">
        <property type="entry name" value="5-OXOPROLINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365">
        <property type="entry name" value="5-OXOPROLINASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19278">
        <property type="entry name" value="Hydant_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05378">
        <property type="entry name" value="Hydant_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01968">
        <property type="entry name" value="Hydantoinase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02538">
        <property type="entry name" value="Hydantoinase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydantoinase/oxoprolinase N-terminal" evidence="4">
        <location>
            <begin position="9"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="Hydantoinase A/oxoprolinase" evidence="2">
        <location>
            <begin position="234"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="domain" description="Acetophenone carboxylase-like C-terminal" evidence="5">
        <location>
            <begin position="547"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="domain" description="Hydantoinase B/oxoprolinase" evidence="3">
        <location>
            <begin position="738"/>
            <end position="1274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF19278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBF74975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="1274" mass="138939" checksum="FCA7769D8E0CA2AC" modified="2005-04-26" version="1">MAENCKITISIDRGGTFTDVHAVVPGRPDIILKLLSVDPAHYQDAPTEGVRQILELVTGKPHPRGQPLELGPIESLRMGTTVATNALLERKGARSALLTTKGFRDLLRIGDQSRPNIFDLTMARPGMLPEAVVEIDERIVPVHPASDKDCFSGARLVEGVTGEKFRVVKELDIEKVRPELERLKEKGYQSLSVALVHSYVYPEHERLIGELAEQMGFSVTLSSKLQPMIKIVPRGMSAAADAYLTPVIKTYIDSISSSFEGGLANQHSCRFEFMQSDGGLVDFRKFSGLKAILSGPAAGVVGFAATSWDAEEKTPVIGFDMGGTSTDVSRFDGHLEHVFGSKLAGVQIQSPQLDINTVAAGGGSILNWRNGLFYVGPESASAHPGPACYRKGGPLTVTDANLFLGRLLPEFFPHIFGENEDQPLDLEVTTKKFKELTDTVNAERRQKGESEYTPEEVALGFLKVADESMARPIRNLTEARGFETATHHLASFGGAGGQHACPVAASLGISRIIIHKFSSVLSAYGLALAEVVKESQEPLSTQYESSKPELKKKLAEMTEAAVEDMKEQGFSSDQVRHERYLNLRYDGSDTSLMILEPEDGSDFIEQFRERHRREFGFNSDRPVLVDDIRVRTIAASKVRDEKSPLVQLREAKIRDITSSPDLITKTFFDGQKGRVDTPVFKLDNIEKNSRIHGPAIIIDNTQTIVVVPNAVANVLETCILIDLKETRSTENKPTSGIDTIKLSIFGHRFMSIAEQMGRTLQKTAVSTNIKERLDFSCALFSPDGGLVANAPHVPVHLGSMQFAVRYQHKKWLGNLKDGDVLVANHPSCGGTHLPDITVITPVFDKPGGSEIMFYVASRGHHADIGGILPGSMPPKSTELWQEGAAIEGDKVVSNGKFDEERMVELLVKKPAQYPGCSGARCITDNISDLKAQIAANTRGITLIQALFAEYGVQTVQKYMYAIQETAETAVRNLLKDLYHRFEGRPLEAVDYMDDGTPIKLKVTINGDDGSAVFDFEGTGPQVYGAWNAPIAITHSAIIYCLRCMINADMPLNQGCLAPIDIKVPPSCLLSPTKNAAVVGGNVVTSQRVTDVVFKAFRACAASQGCCNNLTFGKNAKKDPENGNEIPGFGYYETIAGGSGAGPTWDGESGIHVHMTNTRITDPEILEKRYPTLLRQFTLRSGSGGKGQHPGGEGVIREIEFLTPMDCSILSERRVHRPYGLEGGENAEPGMNLWITKDKDTGEDHTVNIGGKNTIHVETHDRIVIMTPGGGGWGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B7D0</accession>
    <accession>C8V4I1</accession>
    <name>Q5B7D0_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ANIA_03550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF75906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_661154.1">
        <property type="nucleotide sequence ID" value="XM_656062.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B7D0"/>
    <dbReference type="STRING" id="227321.Q5B7D0"/>
    <dbReference type="GeneID" id="2872975"/>
    <dbReference type="KEGG" id="ani:ANIA_03550"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN3550"/>
    <dbReference type="eggNOG" id="ENOG502SUZN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078259_0_0_1"/>
    <dbReference type="InParanoid" id="Q5B7D0"/>
    <dbReference type="OMA" id="DANIPSW"/>
    <dbReference type="OrthoDB" id="4510091at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF75906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="297" mass="33509" checksum="3B0AB267B18ADB35" modified="2005-04-26" version="1">MDRLLVELLEIIILFTLQASLKHLLSVNRLFRALCIPSLFQSVQVGVTFAQLEGLLQISKSSFAPFVRAIRYEANALLDPKKEKILWTSQDILCMSLRDLPNLHTLEINLVNRIKDQFGHASGCMLPYHDYYLGPLEKLLTAAVMARKNSVMIRAFHIRGFYHQAAIEDCFLQALASKALPDVEEICITSTSPMLPFLNKLPLLKLQHLELIDIWLSLPALENFIRQAVHLKSLYLEDVWLVDELAAHPGGEFGISKGLATTIIEVLTRLSRPLEMTITHCGNTRQFGSNSTTVFQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B7J8</accession>
    <accession>C8V559</accession>
    <name>Q5B7J8_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_03482</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF76064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_661086.1">
        <property type="nucleotide sequence ID" value="XM_655994.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B7J8"/>
    <dbReference type="GeneID" id="2872905"/>
    <dbReference type="KEGG" id="ani:ANIA_03482"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN3482"/>
    <dbReference type="HOGENOM" id="CLU_1004824_0_0_1"/>
    <dbReference type="InParanoid" id="Q5B7J8"/>
    <dbReference type="OrthoDB" id="5358475at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="29"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF76064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="277" mass="29246" checksum="45F2C92E21AADC4F" modified="2005-04-26" version="1">MSQAVPAETASTSTRTENHTTTTDKEESSSTTETTYPTTTTIEILTGTTTTTITITGTPKPYTTSTGTSSTTSDTSTDGDPTPQATVTIYSPLPTSNRSGNSLTTGAKAGIGIGVALGVLLVILGAMIFLRRYRGSAKGGNTGRSELDSAPISESANKTDSPVEMEATERRVFELPTKSGLAESGANWQYAIDPTSVAIHQDYNRDGQLRNPIWAQNATPVALFADAWLVPWEENLGNAPVSPKYPNVTGSPSKIRLIPYGSTKLHIADFPIAVQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="132" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B877</accession>
    <accession>C8VI52</accession>
    <name>Q5B877_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Cytochrome P450, putative (Eurofung)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">ANIA_03253</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF83094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_660857.1">
        <property type="nucleotide sequence ID" value="XM_655765.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B877"/>
    <dbReference type="GeneID" id="2874199"/>
    <dbReference type="KEGG" id="ani:ANIA_03253"/>
    <dbReference type="eggNOG" id="KOG0157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022195_0_1_1"/>
    <dbReference type="InParanoid" id="Q5B877"/>
    <dbReference type="OMA" id="HEFIFPN"/>
    <dbReference type="OrthoDB" id="1844152at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd11041">
        <property type="entry name" value="CYP503A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206:SF6">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE AN1598-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-0349">Heme</keyword>
    <keyword evidence="9 12" id="KW-0408">Iron</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="459"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CBF83094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="520" mass="59195" checksum="462D8D87DD2B01AB" modified="2005-04-26" version="1">MEDPSSLPSLYPGLFVLFLLYFAGDLIATRRAAQRQKDHPLVGSPSWWTPRFGLNLVFAARAVEILQTGYHKFKNRTFQLIRGDGSVVILPLHLIDELSSLPQSVASSHGALERDLLGRYTGLDIILTSRMHHTIVQRKLTPRLAALTPSLQDEVSLAVQEGFPHSTEWTIVKPYQILAQVAAKIAARAMVGPSFCRDPRWLDISVNYTESLFRTIVILRLFPGWTHPVLSRCLPSYWAGKRYLQRAKGILGPKIDELIRRNDTGEWSPERTESDFNVLCWLVEAAKGRDRNAETLAHIEVLLALAAVHTILLRLVNVLYDLVAHPALFEELKEEIQDIGFNEDWNFGSYNKLRKLDSVLRESQRLSPPTILGLKRLFLQPYKFTSGITVPAGTYVALPVMAIENDPLHTDNPEEFDGLRSYRRIEQKTASMRPNPKDGPQFSTIEKTVLGFGYGKSACPGRYFASLVLKMVFVKLLTEYDFQFLPGRSRPKNYLVHEFLFPWPWDKILVRRRENGVCPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="104" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B8J3</accession>
    <accession>C8VII1</accession>
    <name>Q5B8J3_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PARP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ANIA_03137</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF83336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_660741.1">
        <property type="nucleotide sequence ID" value="XM_655649.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B8J3"/>
    <dbReference type="STRING" id="227321.Q5B8J3"/>
    <dbReference type="GeneID" id="2874489"/>
    <dbReference type="KEGG" id="ani:ANIA_03137"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN3137"/>
    <dbReference type="eggNOG" id="ENOG502S6PY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045993_3_0_1"/>
    <dbReference type="InParanoid" id="Q5B8J3"/>
    <dbReference type="OMA" id="CKNKECQ"/>
    <dbReference type="OrthoDB" id="429950at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1740.10">
        <property type="entry name" value="Zinc finger, PARP-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001510">
        <property type="entry name" value="Znf_PARP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036957">
        <property type="entry name" value="Znf_PARP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00645">
        <property type="entry name" value="zf-PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01336">
        <property type="entry name" value="zf-PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50064">
        <property type="entry name" value="ZF_PARP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PARP-type" evidence="7">
        <location>
            <begin position="4"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="100"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="100"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="134"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="149"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="217"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBF83336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="279" mass="31100" checksum="B99392AA229CC6C2" modified="2005-04-26" version="1">MPSYRLEQASTGRAGCQNKECKEQKIKIAKGELRLGSWVDTERFQSWFWRHWGCVTPKVIANINELVGEGDDRDLETLDGYEDLPAELQEKVARALDQGHVDDEDWRGDPEMNVRGSSGFRVRASAKAKKAKDADEEEKDDAAEEQKTPAKKTKKAKKAEHADDEENDDATKEKKSPSSKSKKRSRVQVDDNNHDAGAASPKRSKRTPTRIPKQVPAISSQSDDSANESPEPKRRPAKRGHQAKEAKPAPKRGKKKAVEDSEVEPAAEKPKRGRKKAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="145" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B8R5</accession>
    <accession>C8VIQ8</accession>
    <name>Q5B8R5_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ANIA_03065</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF83473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_660669.1">
        <property type="nucleotide sequence ID" value="XM_655577.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B8R5"/>
    <dbReference type="STRING" id="227321.Q5B8R5"/>
    <dbReference type="GeneID" id="2874391"/>
    <dbReference type="KEGG" id="ani:ANIA_03065"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN3065"/>
    <dbReference type="eggNOG" id="KOG0032">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_63_0_1"/>
    <dbReference type="InParanoid" id="Q5B8R5"/>
    <dbReference type="OMA" id="RPKVQPC"/>
    <dbReference type="OrthoDB" id="40902at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004683">
        <property type="term" value="F:calcium/calmodulin-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071277">
        <property type="term" value="P:cellular response to calcium ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106057">
        <property type="term" value="P:negative regulation of calcineurin-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010972">
        <property type="term" value="P:negative regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051783">
        <property type="term" value="P:regulation of nuclear division"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd05117">
        <property type="entry name" value="STKc_CAMK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000257">
        <property type="entry name" value="Calcium/calmodulin-dependent protein kinase type I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000153">
        <property type="entry name" value="Calcium/calmodulin-dependent protein kinase type I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="18"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="336"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="338"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="379"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBF83473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="404" mass="45712" checksum="EC7A1BF43A2B5189" modified="2005-04-26" version="1">MASQVQPGQKPKVQPCRYKTGKTLGAGSYSVVKECVHIDTGQYYAAKVINKRLMVGREHMVRNEIAILKQVSTGHQNILTLVDYFETMNNLYLVTDLALGGELFDRICRKGSYYESDAADLVRAILSAVAYLHDHGIVHRDLKPENLLFRTPEDNADLLIADFGLSRIMDEEQLHVLTTTCGTPGYMAPEIFDKSGHGKPVDIWAIGVITYFMLCGYTPFDRETNLEEVQAIATANFSFTPVEYWRGVSQEARDFIKRCLTVNPKKRMTAHQALQHPWINPPYDTTDDLGSGEDLLPNIKKNFNARRTLHKAIDTVRAINKLRENGGLMMDGIMSVDPKPEHVNGSEVVEDRTTPRERENEDAMEIDSRSNARGQTEQQIREQERKVKETVAGLWSRTAPRSER</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="120" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B913</accession>
    <accession>C8VJ07</accession>
    <name>Q5B913_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">tRNA dihydrouridine synthase (Smm1), putative (AFU_orthologue AFUA_3G08390)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">ANIA_02967</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Specifically modifies U47 in cytoplasmic tRNAs. Catalyzes the synthesis of dihydrouridine in some mRNAs, thereby affecting their translation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a 5,6-dihydrouridine in mRNA + NAD(+) = a uridine in mRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69851"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="8">
            <dbReference type="Rhea" id="RHEA:69853"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 5,6-dihydrouridine in mRNA + NADP(+) = a uridine in mRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69855"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="9">
            <dbReference type="Rhea" id="RHEA:69857"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF83649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_660571.1">
        <property type="nucleotide sequence ID" value="XM_655479.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B913"/>
    <dbReference type="FunCoup" id="Q5B913">
        <property type="interactions" value="827"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5B913"/>
    <dbReference type="GeneID" id="2873785"/>
    <dbReference type="KEGG" id="ani:ANIA_02967"/>
    <dbReference type="eggNOG" id="KOG2334">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013299_3_2_1"/>
    <dbReference type="InParanoid" id="Q5B913"/>
    <dbReference type="OMA" id="GPIRTNS"/>
    <dbReference type="OrthoDB" id="10262250at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017150">
        <property type="term" value="F:tRNA dihydrouridine synthase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102264">
        <property type="term" value="F:tRNA-dihydrouridine20 synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002943">
        <property type="term" value="P:tRNA dihydrouridine synthesis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052582">
        <property type="entry name" value="tRNA-DUS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45936">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(20) SYNTHASE [NAD(P)+]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45936:SF1">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(20) SYNTHASE [NAD(P)+]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="DUS-like FMN-binding" evidence="11">
        <location>
            <begin position="23"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="376"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00045934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CBF83649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="437" mass="47044" checksum="7D0EBB2922CD0D49" modified="2005-04-26" version="1">MTSCPKRVPIPANGVDYRGKVVLAPMVRSGELPSRLLALKYGADLCWGPETIDRAMIGTTRRVNPRNGCIEFTRMPSNSVNKDDAKESVIYRLDPAREKGKLIFQMGTANPELAVQAGKLVAADVNGIDVNSGCPKPFSTSGGMGAALLRTPDKLVSILEALVKEVGEPYQIGISVKIRLLETPELTESLVSRLVRTGITGLTIHCRTTPMRPRERAIRDQLRMIVSTCHNAGVACIMNGDVTSRDEALALMQEYGADGAMIATAAEANSSCFRSEADGGLAPWREVVHEYVKLCIECENRFGNTKYLINMLIPGKDKEFREAKQAKCYTDLCTILQHDDLMPAAQEVDEILGIAHKSTARSKAVENAIANNDTARAAGGVSRSKNTSPATGGIGPIRTNSIPKPMKAETKAESKPAATDVDVSTPAPQPSQNEVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B9D5</accession>
    <accession>C8VJE0</accession>
    <name>Q5B9D5_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_02845</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CTAG/PCC1 family.</text>
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        <property type="nucleotide sequence ID" value="XM_655357.1"/>
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    <dbReference type="AlphaFoldDB" id="Q5B9D5"/>
    <dbReference type="STRING" id="227321.Q5B9D5"/>
    <dbReference type="GeneID" id="2874008"/>
    <dbReference type="KEGG" id="ani:ANIA_02845"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN2845"/>
    <dbReference type="eggNOG" id="ENOG502S9SP">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="OrthoDB" id="10025739at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
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    <dbReference type="GO" id="GO:0000408">
        <property type="term" value="C:EKC/KEOPS complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070525">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="entry name" value="Transcription factor Pcc1"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="3.30.310.50">
        <property type="entry name" value="Alpha-D-phosphohexomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015419">
        <property type="entry name" value="CTAG/Pcc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31283">
        <property type="entry name" value="EKC/KEOPS COMPLEX SUBUNIT PCC1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31283:SF5">
        <property type="entry name" value="EKC_KEOPS COMPLEX SUBUNIT LAGE3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09341">
        <property type="entry name" value="Pcc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF83886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="113" mass="12211" checksum="3DF9D63B83442565" modified="2005-04-26" version="1">MAANQPSDTEFPCTLTISLPLPSHRLASSAMRALEVDAELSPHVRRCFALKSSEPQEQSTGGDEGKTVLETTYKATTNRMLRVAVNGFMESLGVVLGVMEELDVDVLKGEGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BB60</accession>
    <accession>C8VML1</accession>
    <name>Q5BB60_EMENI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_02220</name>
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    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF86407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_659824.1">
        <property type="nucleotide sequence ID" value="XM_654732.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BB60"/>
    <dbReference type="GeneID" id="2875750"/>
    <dbReference type="KEGG" id="ani:ANIA_02220"/>
    <dbReference type="HOGENOM" id="CLU_1209817_0_0_1"/>
    <dbReference type="InParanoid" id="Q5BB60"/>
    <dbReference type="OMA" id="HACEVND"/>
    <dbReference type="OrthoDB" id="4492028at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF86407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="229" mass="24944" checksum="7231D5C782F892A0" modified="2005-04-26" version="1">MERKRLSGVESPRPQAHENNATSNQGNRVHPSGKRVFEVFGTRNSASVKSNHSLSKKASPYTDKFFANVAEAIVRSFPFTEFAKENSCEIKDVVRALKVTVVEPLSKPSIQKSSTPAEYAQREPATLGSAPSIPLPPVDPQNRRWIVSRQPGQTTPPSATSGSTRFEVSSTATSEPSILLKGGRGVKRRKTMVPVEQQIIKQDAYGNYVPVKSITTASGRFGDDGSKEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="102" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BB96</accession>
    <accession>C8VMH3</accession>
    <name>Q5BB96_EMENI</name>
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        <submittedName>
            <fullName evidence="8">RING finger domain protein, putative (AFU_orthologue AFUA_2G08770)</fullName>
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    <gene>
        <name evidence="8" type="ORF">ANIA_02184</name>
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    <organism evidence="8 9">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
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        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF86341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="XP_659788.1">
        <property type="nucleotide sequence ID" value="XM_654696.1"/>
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    <dbReference type="AlphaFoldDB" id="Q5BB96"/>
    <dbReference type="STRING" id="227321.Q5BB96"/>
    <dbReference type="GeneID" id="2875338"/>
    <dbReference type="KEGG" id="ani:ANIA_02184"/>
    <dbReference type="eggNOG" id="KOG3039">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053742_1_1_1"/>
    <dbReference type="InParanoid" id="Q5BB96"/>
    <dbReference type="OMA" id="PCVTKFM"/>
    <dbReference type="OrthoDB" id="116827at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
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        <property type="term" value="F:zinc ion binding"/>
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        <property type="entry name" value="RING finger domain protein, putative"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
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    <dbReference type="InterPro" id="IPR016818">
        <property type="entry name" value="NOSIP"/>
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    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
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    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
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    <dbReference type="PANTHER" id="PTHR13063">
        <property type="entry name" value="ENOS INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13063:SF10">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-INTERACTING PROTEIN"/>
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    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
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    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
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    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
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            <begin position="262"/>
            <end position="336"/>
        </location>
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        <location>
            <begin position="344"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="66"/>
            <end position="105"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="344"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBF86341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="397" mass="44084" checksum="2606DC1D354BD6EB" modified="2005-04-26" version="1">MAHSKRNTSLPHFTSYERSLLRTAWGTQRGVIGRDSFLPFGSCRLCLHPSRTPSVACATNGDLFCRECAINDLLAQRKEIARLEKEREEARKRLEEESGRELEEARGREVREFEMVSMGFDDWGRAGNKKRKADGDAGVDDDEIWERVKKREVDVGGGVRKQVFELDDKTVEGVMRRERERLMEEIRREKSESSKSALPSFWIPSLTPGTDPNEIAANKTVKLSPICPGSTESNKHGYSLKSLVDVHFTEEAGADGATVRVCPSCKKTLTNTVKAMLMAVLMFAMLLVTKPCGHVICKPCVDKFMTPHDAPDPHATKEEQEKTAELHGRVLCYVCETDLTPRDPARDEKAAAGEKKKKKKKDKEGIQPGLVELSSEGTGFAGRGGNVATKAGVAFQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="129" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BBB2</accession>
    <accession>C8VMA2</accession>
    <name>Q5BBB2_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TRAF-like signal transducer, putative (AFU_orthologue AFUA_2G15830)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ANIA_02168</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF86306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_659772.1">
        <property type="nucleotide sequence ID" value="XM_654680.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BBB2"/>
    <dbReference type="STRING" id="227321.Q5BBB2"/>
    <dbReference type="GeneID" id="2875643"/>
    <dbReference type="KEGG" id="ani:ANIA_02168"/>
    <dbReference type="eggNOG" id="KOG0297">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019709_1_1_1"/>
    <dbReference type="InParanoid" id="Q5BBB2"/>
    <dbReference type="OMA" id="PLTTICG"/>
    <dbReference type="OrthoDB" id="1630758at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
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    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001293">
        <property type="entry name" value="Znf_TRAF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10131">
        <property type="entry name" value="TNF RECEPTOR ASSOCIATED FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10131:SF94">
        <property type="entry name" value="TNF RECEPTOR-ASSOCIATED FACTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02176">
        <property type="entry name" value="zf-TRAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50145">
        <property type="entry name" value="ZF_TRAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="36"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="TRAF-type" evidence="7">
        <location>
            <begin position="96"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="TRAF-type" evidence="4">
        <location>
            <begin position="96"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="272"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="384"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="272"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="284"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="296"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="393"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="423"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBF86306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="434" mass="48082" checksum="70A6948A5C4CA77C" modified="2005-04-26" version="1">MKLDQFLAMEVGSDQDGLIDLRGLEYISDYDDHLMCPICHCPFIRPVRLGCDHVFCQTCLNFAIRTFAPGRDDFTCPTCRTPTRDVYLNVPRLLNNMCDDLPVRCPFSPEGCKEVVPRGHIQSHADKYCRYKLMDCPSPSCDEKTRKKDLSPENKCMHELHKCLRCDADIMEQDYEVTVFRKALREHIDSCPEAVHPCAASKYGCSIRMKRAELGTHEQSCPLISIGPYFEAQNARLDSMELTVRHLQQRNEILDDGLASIRSTLVESSRAFSAHHSNSNNDETASSSSAVADTTNPSSAIPTDAEASTSSLTNATTYLLSLHESLREEVAQLSHAITDLDARASMAIMNECLRLKEDMAHTNAAVGSIRMQVQWLMNPRLHQGQRTQNNSEARGGTHSAAGAGASSSSSGPAPGYGLLRPRRLSDTGREGTKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="110" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BC39</accession>
    <accession>C8VKJ1</accession>
    <name>Q5BC39_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Asparaginase (Eurofung)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ANIA_01891</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF85767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_659495.1">
        <property type="nucleotide sequence ID" value="XM_654403.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BC39"/>
    <dbReference type="STRING" id="227321.Q5BC39"/>
    <dbReference type="GeneID" id="2874583"/>
    <dbReference type="KEGG" id="ani:ANIA_01891"/>
    <dbReference type="eggNOG" id="KOG1592">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021603_1_0_1"/>
    <dbReference type="InParanoid" id="Q5BC39"/>
    <dbReference type="OMA" id="VCLDRWG"/>
    <dbReference type="OrthoDB" id="2262349at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04701">
        <property type="entry name" value="Asparaginase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.30">
        <property type="entry name" value="(Glycosyl)asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000246">
        <property type="entry name" value="Peptidase_T2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10188:SF43">
        <property type="entry name" value="ASPARAGINASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10188">
        <property type="entry name" value="L-ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01112">
        <property type="entry name" value="Asparaginase_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="215"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="243"/>
            <end position="246"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="359"/>
            <end position="362"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Cleavage; by autolysis" evidence="3">
        <location>
            <begin position="214"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBF85767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="474" mass="52524" checksum="02C88C75B62CA5C7" modified="2005-04-26" version="1">MTLKPTFKPTLILHGGAGAIHRSTLPPELWAKYEASLLTYLRATRHLLDNGARALDAAIHAVSLMEDDELFNCGRGSVFTTAGTIEMEASVMVTTVRGEDDVPNNSDTMKRGAGVIGIRNVRHPIQLAREVLTRTGQDENGDPKGGDGSRNASMHSQLAGPYIEELAREWGLEFKPDEWFWTKKRWEEHRRGLEKRQSQVESEPVLGYGYPSQGTVGCVCLDQWGDLAVATSTGGLTNKLPGRVGDTPTLGAGFWAETWEVEVGDHSSSLPMRQPERMQYRQSRAEQNPLLRARQKSMWDITLADCWPDFYHFFKDRPSFETDPYLDTTVTLVKPSHLDIKSRCLQYQKKRRAVAVSGTGNGDSFLRTAAARTACAMMRFSHETVSLADAVTAVAGINGELQRSAGRRWGKTGEGQGGIIGIEAEFDVAAAGYGLRRGKVVFDFNCGGMFRAWFEEGVDGSDIEHVMVFKEPYR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2025-06-18" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BC93</accession>
    <accession>C8VPP9</accession>
    <name>DEWB_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Class I hydrophobin dewB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">dewB</name>
        <name type="ORF">ANIA_01837</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="e94546" last="e94546">
            <title>Six hydrophobins are involved in hydrophobin rodlet formation in Aspergillus nidulans and contribute to hydrophobicity of the spore surface.</title>
            <authorList>
                <person name="Gruenbacher A."/>
                <person name="Throm T."/>
                <person name="Seidel C."/>
                <person name="Gutt B."/>
                <person name="Roehrig J."/>
                <person name="Strunk T."/>
                <person name="Vincze P."/>
                <person name="Walheim S."/>
                <person name="Schimmel T."/>
                <person name="Wenzel W."/>
                <person name="Fischer R."/>
            </authorList>
            <dbReference type="PubMed" id="24722460"/>
            <dbReference type="DOI" id="10.1371/journal.pone.0094546"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBUNIT</scope>
        <scope>INDUCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <comment type="function">
        <text evidence="3 5">Aerial growth, conidiation, and dispersal of filamentous fungi in the environment rely upon a capability of their secreting small amphipathic proteins called hydrophobins (HPBs) with low sequence identity. Class I can self-assemble into an outermost layer of rodlet bundles on aerial cell surfaces, conferring cellular hydrophobicity that supports fungal growth, development and dispersal; whereas Class II form highly ordered films at water-air interfaces through intermolecular interactions but contribute nothing to the rodlet structure (Probable). DewB is a class I hydrophobin that contributes to the hydrophobicity of the spore surface (PubMed:24722460).</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Self-assembles to form functional amyloid fibrils called rodlets. Self-assembly into fibrillar rodlets occurs spontaneously at hydrophobic:hydrophilic interfaces and the rodlets further associate laterally to form amphipathic monolayers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Spore wall</location>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="3">Expressed after 12 to 24 hours post induction of asexual development, which correlates with the development of metulae and phialides (PubMed:24722460). Not expressed in hyphae and strongly induced during development (PubMed:24722460).</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the fungal hydrophobin family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF85659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_659441.1">
        <property type="nucleotide sequence ID" value="XM_654349.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BC93"/>
    <dbReference type="STRING" id="227321.Q5BC93"/>
    <dbReference type="EnsemblFungi" id="CBF85659">
        <property type="protein sequence ID" value="CBF85659"/>
        <property type="gene ID" value="ANIA_01837"/>
    </dbReference>
    <dbReference type="GeneID" id="2874680"/>
    <dbReference type="KEGG" id="ani:ANIA_01837"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN1837"/>
    <dbReference type="eggNOG" id="ENOG502T10M">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_106380_1_0_1"/>
    <dbReference type="InParanoid" id="Q5BC93"/>
    <dbReference type="OMA" id="QAQSKCG"/>
    <dbReference type="OrthoDB" id="4225815at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031160">
        <property type="term" value="C:spore wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005199">
        <property type="term" value="F:structural constituent of cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048315">
        <property type="term" value="P:conidium formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001338">
        <property type="entry name" value="Class_I_Hydrophobin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01185">
        <property type="entry name" value="Hydrophobin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00075">
        <property type="entry name" value="HYDRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0183">Conidiation</keyword>
    <keyword id="KW-1015">Disulfide bond</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <keyword id="KW-0749">Sporulation</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013988760" description="Class I hydrophobin dewB">
        <location>
            <begin position="18"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="35"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="43"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="44"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="Q04571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="24722460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="4">
        <source>
            <dbReference type="PubMed" id="24722460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBF85659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="135" mass="13415" checksum="A5DC70C324DA37B5" modified="2005-04-26" version="1" precursor="true">MKFIGLATLSLFALASADKFPVPDSITVAEGSSKCGDQAQLSCCNDVKYGGDTTVVQKGIAAGLLSDLLGAGSAAEGLGAFSGCSKLDISLLIGIEDILNQKCKQNIACCAKSGGSADGDLVGATLPCIALGSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="117" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BCQ3</accession>
    <accession>C8VNS5</accession>
    <name>Q5BCQ3_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Short chain dehydrogenase, putative (AFU_orthologue AFUA_4G08710)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ANIA_01677</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF85349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_659281.1">
        <property type="nucleotide sequence ID" value="XM_654189.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BCQ3"/>
    <dbReference type="GeneID" id="2875004"/>
    <dbReference type="KEGG" id="ani:ANIA_01677"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN1677"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_1_1"/>
    <dbReference type="InParanoid" id="Q5BCQ3"/>
    <dbReference type="OMA" id="KDANTMF"/>
    <dbReference type="OrthoDB" id="1669814at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000245">
        <property type="entry name" value="Short chain dehydrogenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF4">
        <property type="entry name" value="CHAIN DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G08710)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBF85349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="287" mass="31088" checksum="73D84BD77BA21507" modified="2005-04-26" version="1">MSVSIETTSTPVVPLKQEAPAVATTNRLPEFSLAGKVVCVSGGARGLGLTQAEALLEAGARVYALDRLEEPSPDFYTIQKRAREELGTELQYRRIDVRDTELLHSTIEAIANAEGRMDGLVAAAGIQQETPALEYTAQDANRMFEVNITGVMMTAQAVAKQMIRFGNGGSIALIASMSGTIANRGLICSAYNASKAAVIQLARNLASEWGQYNIRVNTISPGYIVTAMVEQLFVQYPERRDEWPKHNMLGRLSSPQEYRGAAVFLLSDASSFMTGSDLRIDGGHAAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="100" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BCQ7</accession>
    <accession>C8VNS1</accession>
    <name>Q5BCQ7_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phospho-2-dehydro-3-deoxyheptonate aldolase</fullName>
            <ecNumber evidence="6">2.5.1.54</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ANIA_01673</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4 6">
            <text>D-erythrose 4-phosphate + phosphoenolpyruvate + H2O = 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14717"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="2.5.1.54"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="5">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="5">
            <name>Cd(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48775"/>
        </cofactor>
        <text evidence="5">Binds 1 divalent cation per subunit. The enzyme is active with manganese, cobalt or cadmium ions.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 1/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the class-II DAHP synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.54" evidence="6"/>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF85341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_659277.1">
        <property type="nucleotide sequence ID" value="XM_654185.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BCQ7"/>
    <dbReference type="STRING" id="227321.Q5BCQ7"/>
    <dbReference type="GeneID" id="2875563"/>
    <dbReference type="KEGG" id="ani:ANIA_01673"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN1673"/>
    <dbReference type="eggNOG" id="ENOG502QPP7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026885_0_1_1"/>
    <dbReference type="InParanoid" id="Q5BCQ7"/>
    <dbReference type="OMA" id="FKVMMQM"/>
    <dbReference type="OrthoDB" id="2338at2759"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00084"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003849">
        <property type="term" value="F:3-deoxy-7-phosphoheptulonate synthase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002480">
        <property type="entry name" value="DAHP_synth_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21337:SF0">
        <property type="entry name" value="PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21337">
        <property type="entry name" value="PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE 1, 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01474">
        <property type="entry name" value="DAHP_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0104">Cadmium</keyword>
    <keyword evidence="5" id="KW-0170">Cobalt</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="316"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="347"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="379"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="421"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="451"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602480-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBF85341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="482" mass="52563" checksum="7092136A9C4DAC3A" modified="2005-04-26" version="1">MGAEDWNPKSWTSKPIKQDVVYEDVEGVQSALRKLEKLPPLVTTHEIANLKKSLKNVALGKAFVLQGGDCAELFDYCNQDMIEAKVKLLLQMSLVLIWGANMPVVRIARIAGQFAKPRSNPMEVVNGVEMPSFRGDNINGFDATPDSRRPDPSRLVSAYFHSAATLNYLRASLSSGLADLHSPLDWGLGHVITPSIKEKYERIVNRVKDALRFMQTVGIDTDRGVETVDIYTSHEGLLLEYETSLTRLLKDPTPPSSHQPTVTLVPGKGPIPAQTPASSSYYATSSHFLWIGDRTRQLTGAHVEFFRGIANPIGIKIGPSMTPTELVTLLDTVNPTREIGKVTLISRYGAANIAAHLPGHISAVQSSGHIPVWQCDPMHGNTRSTPNGVKTRHFSDILSELKQALEIHKAAGSFLGGMHLELTGEAVTECVGGAGGLTEEGLGERYTTFCDPRLNEKQALELAFLVAGFYREMEGGEGVNSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BDT9</accession>
    <accession>C8VSE4</accession>
    <name>Q5BDT9_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DUF636 domain protein (AFU_orthologue AFUA_1G09754)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ANIA_01291</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF87778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_658895.1">
        <property type="nucleotide sequence ID" value="XM_653803.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BDT9"/>
    <dbReference type="GeneID" id="2877066"/>
    <dbReference type="KEGG" id="ani:ANIA_01291"/>
    <dbReference type="eggNOG" id="ENOG502S4B4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_116419_0_0_1"/>
    <dbReference type="InParanoid" id="Q5BDT9"/>
    <dbReference type="OMA" id="PDEMVCI"/>
    <dbReference type="OrthoDB" id="406544at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1590.10">
        <property type="entry name" value="glutathione-dependent formaldehyde- activating enzyme (gfa)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337:SF44">
        <property type="entry name" value="DUF636 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G09754)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337">
        <property type="entry name" value="GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="5">
        <location>
            <begin position="6"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBF87778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="164" mass="18480" checksum="C2A4DDA3BF6EDF4F" modified="2005-04-26" version="1">MPFRKLEGSCQCGGVEFSLDSSTPVPYQLCACSICRKIGGYVGCVNLGGIADSLKIKKGENLVKKYNAIKARGTKDEEKCTSERNFCSNCATMLWLWDKTWPELIHPFASAIDTELPVPDEMVCIMEGSKPAWARFPEGKKQVFKEYPTDSLEDWHKKHGLFYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="150" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BDZ0</accession>
    <accession>C8VSQ0</accession>
    <name>Q5BDZ0_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">ABC multidrug transporter (Eurofung)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">ANIA_01240</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="16">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF87872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_658844.1">
        <property type="nucleotide sequence ID" value="XM_653752.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BDZ0"/>
    <dbReference type="GeneID" id="2877019"/>
    <dbReference type="KEGG" id="ani:ANIA_01240"/>
    <dbReference type="eggNOG" id="KOG0054">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_27_5_1"/>
    <dbReference type="InParanoid" id="Q5BDZ0"/>
    <dbReference type="OMA" id="CWQMIIT"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd18579">
        <property type="entry name" value="ABC_6TM_ABCC_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18580">
        <property type="entry name" value="ABC_6TM_ABCC_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000055">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000066">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001854">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002145">
        <property type="entry name" value="ABC transporter (MsbA subfamily)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044746">
        <property type="entry name" value="ABCC_6TM_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044726">
        <property type="entry name" value="ABCC_6TM_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF269">
        <property type="entry name" value="ABC MULTIDRUG TRANSPORTER (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="66"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="150"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="193"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="564"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="609"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="673"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="700"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="784"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="14">
        <location>
            <begin position="1"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="285"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="14">
        <location>
            <begin position="660"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="879"/>
            <end position="1099"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CBF87872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="1115" mass="122214" checksum="ED2D0A45F5E33BE8" modified="2005-04-26" version="1">MVRGAIVSMVYRKACTLNLKDADPAESITLMSADIERIVQGWQTMHEMWANVAEIALAVFLLERELGVACVVPVGVTIVALMGCSVCMPLVAARQAMWLEAIERRISATSSMLGSIKGIKMLGLQSFLMKFVHNMRIDELRISKRFRKLLVWNMAFAWITRLFGPMAAFGAFVGIAHNRGQDSALDTSTVYTALSLFSLLADPLMSLVMAMMAFAGSVGSFSRIQAFLEKESHVDPRDEVLTHPFNPLKLSKQLTFVAQSEIAVSESGSSQFSKGSASSLLHHIITVQDGSFGWNTEEEPSVKNVSIAVPSGTLTILVGPSGCGKSTLLKAILGEVPCQDGSIHISTKSVAYCDQSPWHMNASIRECIVAMSAFDEAWYTSVINACALTQDFEQLPCGDETIIGSKGISLSGGQSQRIAIARAVYARRELVIFDDVFSSLDSETENHIFHHLLGDHGLLRSLNATILFASSSVKRVPFADHIIVLEKHGYVTEQGSFSSLNAAGGYISSFALNRAGVDTKISTMHKNEPSSVSEYPPQRASDVELESYRGDGDMSIYLYYIQSVGWLQTVAFAVAITGFVFCISFPSIWVKWWANSNETNPGKHTGYYLGVYAMLGGVGMLCIVAGTCIMKQANDSQNGTEVWGGFSQKTSEHGFKVTCSLFSQDLQLIDMELPVAVINTFAILVLCIFSMIFMGIASKYAAISFPIVLLVIYAIQKIYLRTSRQLRFLDLEAKAPLYSHFTDSLGGLASLRAFGWQQALQEKQYQLLDRSQRPFYLLYAIQRWLTLTLDLVVAGIAVLLVILVVTLRGQISAGYVGVALLNVIMFSQSIKLLVTFWTNLETHIGSIQRVRSFTETVQSEELPAERDPVPPDWPAEGSIEFKSLAAGYRESEPILKDITLSIQAGEKIGICGRTGSGKITIDGLDLTRLPREEIRARLNGVSQSPLLIKGSVRLNANPTATTSIGTNTASDNAILSALKSVNLHTKVIENGGLDADIDDLHLSQGQKQLFCLARAILRSGNILVLDEATSNIDSKTDEIMQRVIRENFSSHTVLTVAHKLESILDYDKVIVLEDGRVIEAGVPYDLLAQENSHFSRLYYAGLNSDGREDESFEPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BDZ4</accession>
    <accession>C8VSQ4</accession>
    <name>Q5BDZ4_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_01236</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF87879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_658840.1">
        <property type="nucleotide sequence ID" value="XM_653748.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BDZ4"/>
    <dbReference type="STRING" id="227321.Q5BDZ4"/>
    <dbReference type="GeneID" id="2877011"/>
    <dbReference type="KEGG" id="ani:ANIA_01236"/>
    <dbReference type="eggNOG" id="ENOG502S92A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_715775_0_0_1"/>
    <dbReference type="InParanoid" id="Q5BDZ4"/>
    <dbReference type="OMA" id="EGIWTPD"/>
    <dbReference type="OrthoDB" id="5426165at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40623">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40623:SF2">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF87879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="386" mass="43028" checksum="764B5F9284D8F830" modified="2005-04-26" version="1">MFILSAMTCFYGSRSTFRVGDQPLVGDLAKVLASADWCPVTTIIAFQVPTGSEHSCSTLTSVPAVKRTSGSLLLQMSTMATTTDSEILLSDCIMDRVHSYIRFDTCMCHWVVGASPEEMGFWKGWALWQKLSIALAFLLLLVLVYSFSVLTYNRRKIRKQAAEEANQRAEDAEMGEAGSESNEIPFGAKALEKGIEVEGIWTMKRHSLVKPASISEKRKSSILGSLLRHKSTASSVQTPHISEPESINSSDPQRKSGSVESQAESVLESIHIDTFRSSRPPKLDIGGRYGQRSSENERPLSRWWFTSRSSWMKPVVGYKRSSVRDGRRRGSSEDFRRRFSKLFDDTIAPVPHQPEMFQLTPIYQASSESSIGQRSADRIITPVAAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="114" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BE05</accession>
    <accession>C8VSR6</accession>
    <name>Q5BE05_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA polymerase epsilon subunit D</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">DNA polymerase II subunit D</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ANIA_01225</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF87900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_658829.1">
        <property type="nucleotide sequence ID" value="XM_653737.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BE05"/>
    <dbReference type="STRING" id="227321.Q5BE05"/>
    <dbReference type="GeneID" id="2877002"/>
    <dbReference type="KEGG" id="ani:ANIA_01225"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN1225"/>
    <dbReference type="eggNOG" id="KOG0870">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043417_2_0_1"/>
    <dbReference type="InParanoid" id="Q5BE05"/>
    <dbReference type="OMA" id="NTYRRKV"/>
    <dbReference type="OrthoDB" id="1707486at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008623">
        <property type="term" value="C:CHRAC"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008622">
        <property type="term" value="C:epsilon DNA polymerase complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd22928">
        <property type="entry name" value="HFD_POLE3_DPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051377">
        <property type="entry name" value="DNA_Pol-Epsilon_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46172">
        <property type="entry name" value="DNA POLYMERASE EPSILON SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46172:SF1">
        <property type="entry name" value="DNA POLYMERASE EPSILON SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="7">
        <location>
            <begin position="48"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="125"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="159"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="183"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="241"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="258"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBF87900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="280" mass="30452" checksum="0422A950E77BC4B3" modified="2005-04-26" version="1">MSTSPPTDADADQAQPNTMQMQATEQQLKARAEGVSIEDYLLPRSITLRLAKSVLPPNTSVQKDAVLAIQKAATVFVSYLSSHANEATLKRTVSPADVLNALSELEFEGFRPRLEKELDKFTDLKAAKRKPRKSGDGDTKANVDAGAESKNGVQAAKDGTGDAEMKEVVVRGSKAKRVKRDGDEEIEKEDQDHDQDPDDEGEDGGDADEVEEEHEEDADATEEEDEEDEEERGEDEDLDRVEDLDRGAQARRLVDPDAAGDSDSDEEGPGSQLRGDLGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="119" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BEV3</accession>
    <accession>C8VUP4</accession>
    <name>Q5BEV3_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 11">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="7 11">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">ANIA_00927</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 15 16">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7 10 11">Belongs to the peptidase C12 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="7 11"/>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF88509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_658531.1">
        <property type="nucleotide sequence ID" value="XM_653439.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BEV3"/>
    <dbReference type="STRING" id="227321.Q5BEV3"/>
    <dbReference type="MEROPS" id="C12.009"/>
    <dbReference type="GeneID" id="2876706"/>
    <dbReference type="KEGG" id="ani:ANIA_00927"/>
    <dbReference type="eggNOG" id="KOG2778">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018316_1_0_1"/>
    <dbReference type="InParanoid" id="Q5BEV3"/>
    <dbReference type="OMA" id="YIQYEIQ"/>
    <dbReference type="OrthoDB" id="1924260at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019784">
        <property type="term" value="F:deNEDDylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071629">
        <property type="term" value="P:cytoplasm protein quality control by the ubiquitin-proteasome system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000338">
        <property type="term" value="P:protein deneddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09617">
        <property type="entry name" value="Peptidase_C12_UCH37_BAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.532.10:FF:000009">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.532.10">
        <property type="entry name" value="Peptidase C12, ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001578">
        <property type="entry name" value="Peptidase_C12_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036959">
        <property type="entry name" value="Peptidase_C12_UCH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017390">
        <property type="entry name" value="Ubiquitinyl_hydrolase_UCH37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041507">
        <property type="entry name" value="UCH_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589:SF16">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE ISOZYME L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01088">
        <property type="entry name" value="Peptidase_C12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18031">
        <property type="entry name" value="UCH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038120">
        <property type="entry name" value="Ubiquitinyl_hydrolase_UCH37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00707">
        <property type="entry name" value="UBCTHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52048">
        <property type="entry name" value="UCH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7 10" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-0647">Proteasome</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 10" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4 7 10" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UCH catalytic" evidence="12">
        <location>
            <begin position="27"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8 10">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8 10">
        <location>
            <position position="202"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="10">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <feature type="site" description="Important for enzyme activity" evidence="9 10">
        <location>
            <position position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR038120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR038120-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR038120-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CBF88509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="337" mass="37505" checksum="76139098FD58EA01" modified="2005-04-26" version="1">MPDIESDWIAKLYSSALQTRKMADTAGWSTIESDEGVFTSLVENLGVKGVQFEELISLDPDTIRSLGTVYGVIFLFKYLRQTPDINTSSSADGTPTDPSTLPPSFFFANQTIQNACGTQAILSVLLNHDTPSPENNNDPITLGPELSSFKDFTTGFPSDLRGEALSNSEAIRTAHNAFARASPFVDETVRPRDEDEEGDVYHFIAYTPVNGTLYELDGLQASPISHGPCDASIFPEKVIEVLQKRIARYPETETRFNLMAVVKDLRIRAAEMGDQEALNTEERKRAGWAWENSLRRSNFVGFIGEVLKGVTKVKEEEGSVEEWVKRAEAETARRLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BF05</accession>
    <accession>C8VPZ5</accession>
    <name>Q5BF05_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Homoserine acetyltransferase family protein (AFU_orthologue AFUA_1G15350)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_00875</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. MetX family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF88613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_658479.1">
        <property type="nucleotide sequence ID" value="XM_653387.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BF05"/>
    <dbReference type="STRING" id="227321.Q5BF05"/>
    <dbReference type="ESTHER" id="emeni-q5bf05">
        <property type="family name" value="Homoserine_transacetylase"/>
    </dbReference>
    <dbReference type="GeneID" id="2876653"/>
    <dbReference type="KEGG" id="ani:ANIA_00875"/>
    <dbReference type="eggNOG" id="ENOG502QVPA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028760_2_0_1"/>
    <dbReference type="InParanoid" id="Q5BF05"/>
    <dbReference type="OMA" id="KLGDWEL"/>
    <dbReference type="OrthoDB" id="9972683at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008220">
        <property type="entry name" value="HAT_MetX-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268:SF15">
        <property type="entry name" value="HOMOSERINE ACETYLTRANSFERASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_1G15350)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268">
        <property type="entry name" value="HOMOSERINE O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="57"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF88613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="326" mass="35933" checksum="9F41D3558A2FB8B8" modified="2005-04-26" version="1">MAQQDYETFELGDWELQSGSKLINAHIAYRTFGDPKSPAIVYPTWFSGAIADNLWLIGEDKTLNPKDYFIIIPALFGNGQSTSPSNYPVEGEWPEVSFYDNVRAQYKLVTGHFGITHLRAVIGWSMGGAQTYQWATQYPDFMDLAVPFCASAKTSLHNQVFLEGVKSALLAAKGIQSAGSGQGGVLVSGHTLRTWNDAEKRVGLKAFGRGYAGWEKLYETALGYADLEDFMQNFWEAWALSKDPGNLLAMAQTWQNGDVSKQEPYNGDFEAALAAIRAKVLVLPAKTDLYFPSVIPQMKRQELTALNRDSLCLPVDLGPLGGRARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="105" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BF18</accession>
    <accession>C8VQ08</accession>
    <name>Q5BF18_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Prefoldin subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ANIA_00862</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 4">Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF88638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_658466.1">
        <property type="nucleotide sequence ID" value="XM_653374.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BF18"/>
    <dbReference type="FunCoup" id="Q5BF18">
        <property type="interactions" value="719"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5BF18"/>
    <dbReference type="GeneID" id="2876638"/>
    <dbReference type="KEGG" id="ani:ANIA_00862"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN0862"/>
    <dbReference type="eggNOG" id="KOG1760">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130032_0_0_1"/>
    <dbReference type="InParanoid" id="Q5BF18"/>
    <dbReference type="OMA" id="KFGRAIN"/>
    <dbReference type="OrthoDB" id="10250441at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd23165">
        <property type="entry name" value="Prefoldin_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.370:FF:000005">
        <property type="entry name" value="Prefoldin subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016661">
        <property type="entry name" value="PFDN4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21100">
        <property type="entry name" value="PREFOLDIN SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21100:SF9">
        <property type="entry name" value="PREFOLDIN SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01920">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016477">
        <property type="entry name" value="Prefoldin_subunit_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="41"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="98"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR016477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBF88638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="138" mass="16022" checksum="60876EB1CD4C6466" modified="2005-04-26" version="1">MMNHRMLSKEDEAAIGNSEDTEVRREDQEKINRFSRLHQRETVLEEKLKGKQKDKEDLEEISTELELADEDELIPYKIGDSFVHLPLEEAQTLLASSTEQIDSEVAKLEETLSDLRDEMQQLKVALYARFGRSINLET</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="111" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BFB5</accession>
    <accession>C8VQW8</accession>
    <name>Q5BFB5_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">3-beta hydroxysteroid dehydrogenase/isomerase family protein (AFU_orthologue AFUA_3G02250)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ANIA_00765</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF88830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_658369.1">
        <property type="nucleotide sequence ID" value="XM_653277.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BFB5"/>
    <dbReference type="STRING" id="227321.Q5BFB5"/>
    <dbReference type="GeneID" id="2876540"/>
    <dbReference type="KEGG" id="ani:ANIA_00765"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN0765"/>
    <dbReference type="eggNOG" id="KOG1502">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_9_2_1"/>
    <dbReference type="InParanoid" id="Q5BFB5"/>
    <dbReference type="OMA" id="TGDDWNP"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000805">
        <property type="entry name" value="3-beta hydroxysteroid dehydrogenase/isomerase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF579">
        <property type="entry name" value="3-BETA HYDROXYSTEROID DEHYDROGENASE_ISOMERASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_3G02250)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="6"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBF88830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="343" mass="37344" checksum="9EF29CDBD023632C" modified="2005-04-26" version="1">MDIKFVLVTGATGFIGAHIVDALLGHGLRVRGATRSLAKGEEMLKARLHYKEQLEFVKINDFENPGGLAEAVKGVDGIIHTASPFTYDTKDNEKELVIPAINGVKAVFEAAAAADASTTKIKRIVLTSSFASVIDVNRRAGPGSGPDGYFTYTAADWNPLSYAEAIDTSTNAVVAYRGSKKFAELAAWEFIRDRKPSFDLVTLCPPMTFGPVVHPVPSVESLNESNAMLWKVAVGEPLPVARVPFWIDVRDLADAHIGALLKPGVGGRRYTVAAPERFSYGLAAGIIKEEFADLRERVTGTRQDVDESHGLDGETAGRELGISYRRFRETVRDLVRQGVERGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="124" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BG29</accession>
    <accession>C8VSX6</accession>
    <name>Q5BG29_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ANIA_00501</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF89357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_658105.1">
        <property type="nucleotide sequence ID" value="XM_653013.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BG29"/>
    <dbReference type="STRING" id="227321.Q5BG29"/>
    <dbReference type="GeneID" id="2876278"/>
    <dbReference type="KEGG" id="ani:ANIA_00501"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_11_0_1"/>
    <dbReference type="InParanoid" id="Q5BG29"/>
    <dbReference type="OMA" id="PYIYNPD"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF41">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="188"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="308"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="343"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="371"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="398"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="438"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="471"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="44"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBF89357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="539" mass="58931" checksum="40F17FD1C7098805" modified="2005-04-26" version="1">MKGTYDKNPAVVGCHGRALSLESSQHQPNESALQSARNSLKTVAWCFALASGIILAYAPMFYSIANDPPILTSSRKDFGRRLDGKLIIPALWLALWNIANPIGGVLGSIAGGYIQDRVGRRGSLTIASVVSAIGVAVAYISDLPSEINGRRSIIFVAKLVQGFAVNQVMCTTQTYMSEVLPPILRGPILGLFPTFILMGQLIGSIIIYAMAARRGPEGYKLCFVSEWPFSVLPFVVSFLMPESPTYLIRENRLDEARRCQEQLSYSTEEADMVFQQCRFSIELEKKAKGSVPGYSDCFKGTNRRRTMVVLFACLLPQLFGISLLARGSYFMQVVGMNAHTSLIFLQVGVGLGLVANVGSMITVAKFGRRPLTLFGLIACTILWMGMGIAGCFPGTATVWYTQMTILFVVTLTGLTIWPASYAFGAEASSLQLRAKTQGLGWLVNCLSNGILGIVLPYIFNDDEGALGAKTGFVYMGFCILSLAAAWRIVPEMKDKTAMEIDQVFTGAQRRIVHGDEEEIAVREREEKAWECGFGRPYVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="104" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BG70</accession>
    <accession>C8VT69</accession>
    <name>Q5BG70_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">F-box domain protein (AFU_orthologue AFUA_1G04380)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_00460</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF89439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_658064.1">
        <property type="nucleotide sequence ID" value="XM_652972.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BG70"/>
    <dbReference type="STRING" id="227321.Q5BG70"/>
    <dbReference type="GeneID" id="2876237"/>
    <dbReference type="KEGG" id="ani:ANIA_00460"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN0460"/>
    <dbReference type="eggNOG" id="ENOG502SUQR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018631_0_0_1"/>
    <dbReference type="InParanoid" id="Q5BG70"/>
    <dbReference type="OMA" id="IDSYESW"/>
    <dbReference type="OrthoDB" id="1259151at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="419"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="422"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF89439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="597" mass="66841" checksum="D533D5AA8F6B37CC" modified="2005-04-26" version="1">MLLSELPPEIIYAIATHLPTANDFICLARTCRRLHKVIASGDWSIFRVFVKSRFYNIPTPPFWKDAAQALTSRSRALDRHAIIGRFVTRPLNAEQLGGSSQATRGDNPTHGYRPAIDSYEIWNGSSWHDRREVLAWSAAHELVLQIRQHGSQRLERSFIFNDLEHISSHDDICGLHLLRPGHYAKRQDWEHMMLGRMRGELVHLAIAPESHTYELRQKFQTFGLELERTDMSDDPESILAAHLSNGTIALYSTTTGEAEVQPFGRLHVDAGSPARYKSSRFLSSDRLAVATGRPEDAIAVFTISQGRLTVEHSLSADFLGSPALTGFAKRSTVTAIAPLTGQTGNSIGNTFLAAWGDGAVRLHDLRSHKPYEGLYIDIADQNPVYCIHPYGHDRFVVGAGGDAVVKIFDIRMPSTYDYNPARRQSSSSRPKGRTTLPTSSAHPSKDLSIFLSLNPPTTRNDSVSRYARHRYRGPIYTMSSPSLLSPTIYTGIAGGVVRLDFASTDDLTGTHKTWYRDSIDLDINCNANIRENYANNIIELSGYERPDSRDTTTCSKLRSQVPFGAVDDQHIANELTTGWDRRWKPLEAPGAWRRRDF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-07-24" modified="2026-01-28" version="120" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BGB9</accession>
    <accession>C8VTH5</accession>
    <name>SAR1_EMENI</name>
    <protein>
        <recommendedName>
            <fullName>Small COPII coat GTPase sar1</fullName>
            <ecNumber>3.6.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">sar1</name>
        <name type="ORF">AN0411</name>
    </gene>
    <organism>
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Small GTPase component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules. SAR1 controls the coat assembly in a stepwise manner. Activated sar1-GTP binds to membranes first and recruits the sec23/24 complex. These sec23/24-sar1 prebudding intermediates are then collected by the Sec13/31 complex as subunits polymerize to form coated transport vesicles. Conversion to sar1-GDP triggers coat release and recycles COPII subunits.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">COPII is composed of at least 5 proteins: the sec23/24 complex, the sec13/31 complex and sar1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">COPII-coated vesicle membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. SAR1 family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.-"/>
    <dbReference type="EMBL" id="AACD01000007">
        <property type="protein sequence ID" value="EAA66510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF89540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_658015.1">
        <property type="nucleotide sequence ID" value="XM_652923.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BGB9"/>
    <dbReference type="SMR" id="Q5BGB9"/>
    <dbReference type="FunCoup" id="Q5BGB9">
        <property type="interactions" value="912"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5BGB9"/>
    <dbReference type="EnsemblFungi" id="CBF89540">
        <property type="protein sequence ID" value="CBF89540"/>
        <property type="gene ID" value="ANIA_00411"/>
    </dbReference>
    <dbReference type="GeneID" id="2876184"/>
    <dbReference type="KEGG" id="ani:ANIA_00411"/>
    <dbReference type="eggNOG" id="KOG0077">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040729_6_0_1"/>
    <dbReference type="InParanoid" id="Q5BGB9"/>
    <dbReference type="OMA" id="GLWNKHG"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044233">
        <property type="term" value="C:mitochondria-associated endoplasmic reticulum membrane contact site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061024">
        <property type="term" value="P:membrane organization"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007006">
        <property type="term" value="P:mitochondrial membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006998">
        <property type="term" value="P:nuclear envelope organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902953">
        <property type="term" value="P:positive regulation of ER to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070863">
        <property type="term" value="P:positive regulation of protein exit from endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003400">
        <property type="term" value="P:regulation of COPII vesicle coating"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016050">
        <property type="term" value="P:vesicle organization"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00879">
        <property type="entry name" value="Sar1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000161">
        <property type="entry name" value="Small COPII coat GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006687">
        <property type="entry name" value="Small_GTPase_SAR1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45684">
        <property type="entry name" value="RE74312P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51422">
        <property type="entry name" value="SAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword id="KW-0931">ER-Golgi transport</keyword>
    <keyword id="KW-0333">Golgi apparatus</keyword>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0653">Protein transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000295515" description="Small COPII coat GTPase sar1">
        <location>
            <begin position="1"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="27"/>
            <end position="34"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="70"/>
            <end position="73"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="129"/>
            <end position="132"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="189" mass="21433" checksum="372CE4A2B97A3325" modified="2005-04-26" version="1">MWIINWFYDILASLGLLNKHAKLLFLGLDNAGKTTLLHMLKNDRVAILSPTAHPTSEELVIGNNRFTTFDLGGHQQARRLWKDYFPEVSGIVFLVDAKDHERFPESKAELDALLAMEELSKVPFLVLGNKIDHPDAVSEDELRHQLGLYQTTGKGKVPLEGIRPIEVFMCSVVMRQGYGEGIRWLSQYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BGE1</accession>
    <accession>C8VTP4</accession>
    <name>Q5BGE1_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_00389</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF89581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_657993.1">
        <property type="nucleotide sequence ID" value="XM_652901.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BGE1"/>
    <dbReference type="GeneID" id="2876166"/>
    <dbReference type="KEGG" id="ani:ANIA_00389"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN0389"/>
    <dbReference type="eggNOG" id="ENOG502RP0P">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1004652_0_0_1"/>
    <dbReference type="InParanoid" id="Q5BGE1"/>
    <dbReference type="OMA" id="MMEFETH"/>
    <dbReference type="OrthoDB" id="4509688at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF89581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="308" mass="33361" checksum="37E004B2FDCF3E0E" modified="2005-04-26" version="1">MTEASMPCDVPNWGFDLANSNSGSTFNYEPGVAGDEELWYRNQFGVGSFDVPPWQPMEMNQGYDFASPASGKTRYQQLPPLSPAQNGGFSARSEGLSPRYGHGEVELPKQRMLTLDGPNRFENVQTENSPYSLDDLLRTASQVATERALYMNIPSTGASTAGANALSPTAEPGISSPGAISSHHSIASDTDEHDLPAFDVPQVYQLPDFSANSNANAAGSLASRDLKETSLTPLEMPDGTTRFTANWLPVDPEGGFTIRPPSHHALGMDLDPMLMDHQVPLYQDHGQHHYNYRNAFISLDNLGGEAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BHB7</accession>
    <accession>C8VR15</accession>
    <name>Q5BHB7_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Integral membrane protein (Ptm1), putative (AFU_orthologue AFUA_5G12390)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">ANIA_00063</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LU7TM family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF90273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_657667.1">
        <property type="nucleotide sequence ID" value="XM_652575.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BHB7"/>
    <dbReference type="FunCoup" id="Q5BHB7">
        <property type="interactions" value="737"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5BHB7"/>
    <dbReference type="GeneID" id="2875844"/>
    <dbReference type="KEGG" id="ani:ANIA_00063"/>
    <dbReference type="eggNOG" id="KOG2568">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024065_1_0_1"/>
    <dbReference type="InParanoid" id="Q5BHB7"/>
    <dbReference type="OrthoDB" id="19932at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053937">
        <property type="entry name" value="GOST_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009637">
        <property type="entry name" value="GPR107/GPR108-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053938">
        <property type="entry name" value="PTM1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21229:SF1">
        <property type="entry name" value="GH17801P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21229">
        <property type="entry name" value="LUNG SEVEN TRANSMEMBRANE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06814">
        <property type="entry name" value="GOST_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21902">
        <property type="entry name" value="PTM1-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010252217" evidence="9">
        <location>
            <begin position="21"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="142"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="178"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="207"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="254"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="298"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="PTM1-like N-terminal" evidence="11">
        <location>
            <begin position="32"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="GOST seven transmembrane" evidence="10">
        <location>
            <begin position="162"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="355"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="355"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="407"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF06814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF21902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CBF90273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="422" mass="47131" checksum="612DC8802BF7A452" modified="2005-04-26" version="1">MRSWIRTLGLSALLAGTAVANEAELGPDLSHRLQCSGMYSRKAWGGSVDPFILTKFAKSSPSDDRDPLVSLAIFEWADGHLIGRRASDDPEEPPSLICDEASVQAELSTGRSYMFKTVTTSVCFFARFLFGCLRSPVPVQNYITAILVFLILEQLMTWGFYVCMGYGVVKPSLGRTMVYVRILAITHFVFAVIYAIASLSITPEAAGILILFIELPLAATLTAFYVWTLSSLNATMKDLIDRKQKTKAMMYKKLWYCLLGSIIVLFGFIFINALAFASRSEEDFLPEHWKNRWFVLDGWLSIVYLADLAFIAYLWRPTANNRRFAMSDELAQDDDGFEIRSFNGALDEEDALGGLDEHSASEPRRDLSPVPPKPVPSAARTRESLDGETIFAVGEDGDKWSDDEDESPRNSTERKALTKDVD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-16" modified="2025-04-09" version="109" xmlns="https://uniprot.org/uniprot">
    <accession>Q8X1Z7</accession>
    <accession>C8VDS1</accession>
    <accession>Q5AV80</accession>
    <name>MIRA_EMENI</name>
    <protein>
        <recommendedName>
            <fullName>Siderophore iron transporter mirA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Enterobactin permease</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Major facilitator iron-regulated transporter A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">mirA</name>
        <name type="ORF">AN7800</name>
    </gene>
    <organism>
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Mol. Microbiol." volume="41" first="1077" last="1089">
            <title>SREA is involved in regulation of siderophore biosynthesis, utilization and uptake in Aspergillus nidulans.</title>
            <authorList>
                <person name="Oberegger H."/>
                <person name="Schoeser M."/>
                <person name="Zadra I."/>
                <person name="Abt B."/>
                <person name="Haas H."/>
            </authorList>
            <dbReference type="PubMed" id="11555288"/>
            <dbReference type="DOI" id="10.1046/j.1365-2958.2001.02586.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2003" name="Biochem. J." volume="371" first="505" last="513">
            <title>Characterization of the Aspergillus nidulans transporters for the siderophores enterobactin and triacetylfusarinine C.</title>
            <authorList>
                <person name="Haas H."/>
                <person name="Schoeser M."/>
                <person name="Lesuisse E."/>
                <person name="Ernst J.F."/>
                <person name="Parson W."/>
                <person name="Abt B."/>
                <person name="Winkelmann G."/>
                <person name="Oberegger H."/>
            </authorList>
            <dbReference type="PubMed" id="12487628"/>
            <dbReference type="DOI" id="10.1042/BJ20021685"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in the transport of siderophore enterobactin and so has a role in iron homeostasis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="sequence caution" evidence="4">
        <conflict type="erroneous gene model prediction">
            <sequence resource="EMBL-CDS" id="CBF80133" version="1"/>
        </conflict>
    </comment>
    <comment type="sequence caution" evidence="4">
        <conflict type="erroneous gene model prediction">
            <sequence resource="EMBL-CDS" id="EAA61588" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EMBL" id="AY027565">
        <property type="protein sequence ID" value="AAK17009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AACD01000132">
        <property type="protein sequence ID" value="EAA61588.1"/>
        <property type="status" value="ALT_SEQ"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF80133.1"/>
        <property type="status" value="ALT_SEQ"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_681069.1">
        <property type="nucleotide sequence ID" value="XM_675977.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8X1Z7"/>
    <dbReference type="SMR" id="Q8X1Z7"/>
    <dbReference type="STRING" id="227321.Q8X1Z7"/>
    <dbReference type="KEGG" id="ani:ANIA_07800"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN7800"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012970_1_1_1"/>
    <dbReference type="InParanoid" id="Q8X1Z7"/>
    <dbReference type="OrthoDB" id="2241241at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042931">
        <property type="term" value="F:enterobactin transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015343">
        <property type="term" value="F:siderophore-iron transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd17322">
        <property type="entry name" value="MFS_ARN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000611">
        <property type="entry name" value="Siderochrome-iron transporter MirC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF87">
        <property type="entry name" value="SIDEROPHORE IRON TRANSPORTER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0406">Ion transport</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0410">Iron transport</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000084859" description="Siderophore iron transporter mirA">
        <location>
            <begin position="1"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="267"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="304"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="346"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="388"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="413"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="480"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="555"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="12487628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="609" mass="66311" checksum="C3D2521A57C1468B" modified="2002-03-01" version="1">MALDDISAVPKGALDTDPAVERPPPLLDADRSDSERLQPGVKRAEMLRKGWTRQGLIIAFTGLFLATLSINFGDYSTQVYVPYATSAFKQHSAMSAARVVGNITRIAAYPIIAKLGDVFGRAEMFILSIVFQAVGYAIYAGCKNVGQYIAGGIFEAIGSTGFGLTQQVFVADVTNLINRAVWSTLPDSLTVIPALYLGTEIAEAVLEKNEWRWGFGMWAIIEPVCSVLLVGTMLYYQKRARKDPSPAEFASEPTERNVDDGWWKRIYNLVWVQLDAFGAILLLLGLSLFLVPLSLTGSGNSDDWHRGSFIAMLVLGVVIFVAFLAWDTWCAKKPFIPYRMIKNRTVAAACLLGILDFFHYSVFSVFFTSYLQVAAHHGAGPATRIDNSLRVAFQVAGIFAAYFMKFTKRSQVWVFTGVPLCVLGMGVLLYLVDMGEGRVGNEAAFVTAKSLIGIGRGFYQTASQVSVQAKVSRGEVSVVTAVFFAAMSIGGAIGTSVAGAIWRSTLPPKLAQHLPAELKDQAQAIFGSIVVAQKYEVGTPARDAIDMCYRQSQRMLAIAALAALAPMLIIMFFLENVPLTDETTLIELHGNREAVKKNHSGGEGKEARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>C8V160</accession>
    <name>C8V160_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ANIA_06622</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF71117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467133.1">
        <property type="nucleotide sequence ID" value="XM_050613233.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V160"/>
    <dbReference type="GeneID" id="2870589"/>
    <dbReference type="KEGG" id="ani:ANIA_06622"/>
    <dbReference type="eggNOG" id="ENOG502RUUF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019101_1_0_1"/>
    <dbReference type="InParanoid" id="C8V160"/>
    <dbReference type="OMA" id="IWGTNNM"/>
    <dbReference type="OrthoDB" id="2988756at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF166">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="168"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="25"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="261"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="303"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="261"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="338"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBF71117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="369" mass="41420" checksum="E345D8486E3D94B8" modified="2009-11-03" version="1">MHEDLSTTLALVGVFGGLSIILMAIRLFMRKYRNQDFILSDYLTMVCIVFVLARSALTTVVLLWGNNNMTRPALNLTETEIYHRTVGSKLTLANRAVYNTYLWIQKSNVLLLCERVLSGLPEPEMIVKVYWIVLLGSLAAVMGTTFGECRPAHLYWQVLPDPGDCVKANIQLVTLVALNITTDAMLILLPMPWLLRVRKSWLKRLQYVLLFSVGLLLIAIAIVRLPVYSSSTNQVNRNTWGSVEEFFAAVAANVPTLFTLRKDPNKHKREEELSHSRPSARPRFTPNQFQDSDLFTTNVALDTVEQTGTEPKRGRSPGRARARSLPVGVTAAPSQENLVRDDSSHVGEGDYGDSHGEYGFDEERRGRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C8V3R8</accession>
    <name>C8V3R8_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">YT521-B-like splicing factor, putative (AFU_orthologue AFUA_7G03780)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ANIA_10537</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF74298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467306.1">
        <property type="nucleotide sequence ID" value="XM_050611261.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V3R8"/>
    <dbReference type="STRING" id="227321.C8V3R8"/>
    <dbReference type="GeneID" id="74896464"/>
    <dbReference type="KEGG" id="ani:ANIA_10537"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN10537"/>
    <dbReference type="eggNOG" id="KOG1902">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011694_2_1_1"/>
    <dbReference type="InParanoid" id="C8V3R8"/>
    <dbReference type="OMA" id="FWEVESS"/>
    <dbReference type="OrthoDB" id="306690at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990247">
        <property type="term" value="F:N6-methyladenosine-containing RNA reader activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000381">
        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21134">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.590.10">
        <property type="entry name" value="ph1033 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057720">
        <property type="entry name" value="RRM_YTH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007275">
        <property type="entry name" value="YTH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045168">
        <property type="entry name" value="YTH_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12357:SF3">
        <property type="entry name" value="YTH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12357">
        <property type="entry name" value="YTH YT521-B HOMOLOGY DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25701">
        <property type="entry name" value="RRM_YTH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04146">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50882">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="299"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="YTH" evidence="4">
        <location>
            <begin position="419"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="202"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="279"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="379"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="492"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="540"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="212"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBF74298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="630" mass="69915" checksum="0EBB71CFFA04C62B" modified="2009-11-03" version="1">MDGGTPQNRPTVAREAKGKNRAPSEPGRSTNPSGAHRQTKVASSRQISHSDNVQQFSQALNYMTPTGNYAHPQSVFVMGNMASALPSYPSGPIQYEQQSIQQQQFVPVCPNPASMYGMPQFQSFPASAPNPSMMFHAPYPQMYMPYVQQQQQHPDATISVANNPNSGSPQNPMGAYGHGYLHPNVYATQGHHSRLANVLRPSPQLYNQTDPNTRKANDGRSKEDKKRITIVDGSAQMKSFVTQGPSAGKRTPCCKLSAVMGEEKEEEEKGKKLTVVVGSAAPRSNLPKGPSRKPKQSGNALWVGNLAPGTNIVELKDHFSQDATKDLESVFLISRSNCAFVNYKTEEACIKALSRFHDTRLRGARLVCRVRRGLMSPGPHSELTGLADQSSMKEAEEMVKTTGTEDDGREGSYSMRVPNRYFILKSLTVEDLELSWQSGIWATQTHNEESLNRAFENADNVYLFFSANKSGEYYGYARMMSTIKDDESLTLEMPPRSEHHSSNEPDSPDVTPAPASRSAPNGRIINDVARGTIFWEADTSEDEEGLPRQHKNAYHPPNEQQSQAPAELQLIGKPFRIRWLSTERVPFHRTRGLRNPWNANREVKIARDGTELEFSVGEKLVLLFHPKSSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>C8V5C4</accession>
    <name>C8V5C4_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phenylalanine--tRNA ligase beta subunit</fullName>
            <ecNumber evidence="5">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Phenylalanyl-tRNA synthetase beta subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">ANIA_04086</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="19">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>tRNA(Phe) + L-phenylalanine + ATP = L-phenylalanyl-tRNA(Phe) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="5"/>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF74738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467367.1">
        <property type="nucleotide sequence ID" value="XM_050611331.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V5C4"/>
    <dbReference type="FunCoup" id="C8V5C4">
        <property type="interactions" value="1087"/>
    </dbReference>
    <dbReference type="STRING" id="227321.C8V5C4"/>
    <dbReference type="GeneID" id="2873508"/>
    <dbReference type="KEGG" id="ani:ANIA_04086"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN4086"/>
    <dbReference type="eggNOG" id="KOG2472">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020279_2_0_1"/>
    <dbReference type="InParanoid" id="C8V5C4"/>
    <dbReference type="OMA" id="FPGRCAN"/>
    <dbReference type="OrthoDB" id="1698572at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009328">
        <property type="term" value="C:phenylalanine-tRNA ligase complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00769">
        <property type="entry name" value="PheRS_beta_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.40.10:FF:000002">
        <property type="entry name" value="phenylalanine--tRNA ligase beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.56.10:FF:000006">
        <property type="entry name" value="Phenylalanyl-tRNA synthetase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.56.10:FF:000004">
        <property type="entry name" value="Phenylalanyl-tRNA synthetase, beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000052">
        <property type="entry name" value="Phenylalanyl-tRNA synthetase, beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.56.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.40.10">
        <property type="entry name" value="Phenylalanyl-trna Synthetase, Chain B, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005146">
        <property type="entry name" value="B3/B4_tRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045060">
        <property type="entry name" value="Phe-tRNA-ligase_IIc_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004531">
        <property type="entry name" value="Phe-tRNA-synth_IIc_bsu_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020825">
        <property type="entry name" value="Phe-tRNA_synthase-like_B3/B4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041616">
        <property type="entry name" value="PheRS_beta_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040659">
        <property type="entry name" value="PhetRS_B1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005147">
        <property type="entry name" value="tRNA_synthase_B5-dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00471">
        <property type="entry name" value="pheT_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10947:SF0">
        <property type="entry name" value="PHENYLALANINE--TRNA LIGASE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10947">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE BETA CHAIN AND LEUCINE-RICH REPEAT-CONTAINING PROTEIN 47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03483">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03484">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18262">
        <property type="entry name" value="PhetRS_B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17759">
        <property type="entry name" value="tRNA_synthFbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00873">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00874">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56037">
        <property type="entry name" value="PheT/TilS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="Putative DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51483">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0436">Ligase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B5" evidence="17">
        <location>
            <begin position="297"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00033189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CBF74738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="600" mass="67739" checksum="1EA6D40BCA5AC383" modified="2009-11-03" version="1">MPTISVDKAALFKELGREYTTEEFDELCFEFGIELDEDTTNSDRPIVDGVQEPPQLKIEIPANRYDLLCFEGIALMLNIFLGRKPLPKYRLVEPPSGELQKIIVKEDTSKIRPLVSGAILRNVTFDKARYESFIALQDKLHQNLARQRTLVSIGTHDLDTIKGPFSYEALPPKDIRFVPLNQTKEMDGEELMAFYDKDKHLGRYLHIIRDSPVYPVIYDANRTVCSLPPIINGEHSKITLNTKNVFIEITALDKTKVEIVNKIMVSMFSQYTSEPFTVEPVQIISEHNNETRVTPDIAPRTTQAEVSYINQCCGLQLSAEEICRLLTKMAYEATPSSTSPDLIDVHIPPTRADILHQADIMEDVAIAYGFNNLPRSFPSKSGTVAQPLPINKLSDIIRTEAAMAGWSEVLPLILCSHDENFAWLNRKDDGNTAVKLANPKTQEFQVVRTSLLPGLLKTIRENKSHSVPMKIFEVSDVAFKDLSMERKSRNERHFAAAWYSKTSGFEVVHGLLDRIMSMLKSAFIIGEEGLENAAVKDSQYWIEELDDPTYFHGHSASIHVRIAGKDHTIGTFGILHPTVLENYGLKYPVSTLEINIETFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C8V7Y1</accession>
    <name>C8V7Y1_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ANIA_05091</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF76097.1"/>
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        <property type="nucleotide sequence ID" value="XM_657603.2"/>
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    <dbReference type="AlphaFoldDB" id="C8V7Y1"/>
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    <dbReference type="KEGG" id="ani:ANIA_05091"/>
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        <property type="component" value="Chromosome III"/>
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    <dbReference type="GO" id="GO:0008168">
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        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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        <property type="entry name" value="AdoMet_MTases"/>
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        <property type="entry name" value="Vaccinia Virus protein VP39"/>
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        <property type="entry name" value="SAM-dependent_MTases_sf"/>
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        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="METHYLTRANSFERASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF76097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="334" mass="37861" checksum="59E67A41244CDA44" modified="2009-11-03" version="1">MSLDPVDEIMPIFPLLEASILGDRPTPQPAHFRVSTVISQNHADPFCAYPVPMSNAIKPKITQRLLTISNERRQNLERSSAGSRDCGGRVYSVNPQAILDVGTGTGIWAIDVADAFPAARVTGLDLSPIQPTFVPPTCSFEIDDVTMPWTYDTEQFDLIYVREMFGSIPDWDAFLRQCWASLRPGGYIEVVEHSITPIWDADTSLGPIYALWEQTMAQVEQVSGRSFSIWRESAQVLEGSGFQDITKRSYKWPISGWNTDPRLRELGRLNQLRLLQAIEDIFLRHLTSTMAWPYDAVQNFIERIRSTIRDEQRHLYQPVTVVYGRKPCPSSEIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>C8V8N8</accession>
    <name>C8V8N8_EMENI</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_04989</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF76332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467578.1">
        <property type="nucleotide sequence ID" value="XM_050611561.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V8N8"/>
    <dbReference type="GeneID" id="2872786"/>
    <dbReference type="KEGG" id="ani:ANIA_04989"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN4989"/>
    <dbReference type="eggNOG" id="ENOG502SSTB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_150197_0_1_1"/>
    <dbReference type="InParanoid" id="C8V8N8"/>
    <dbReference type="OMA" id="GWVGYQI"/>
    <dbReference type="OrthoDB" id="4083871at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42077">
        <property type="entry name" value="YALI0F30239P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42077:SF1">
        <property type="entry name" value="YALI0F30239P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF76332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="116" mass="12962" checksum="72D9914331A7B761" modified="2009-11-03" version="1">MANRLIPLVVLLIVVVVLAVIGFVAYSIIQEVSDKTRSKMEKRNVMFTKDGMKVGVREVGEEEYVDRSQSILVNIWNHTSFPAYKSRLWNMTGSTGSASGTGNGEFRAEHRKGRSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
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    <name>C8V8V7_EMENI</name>
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        <submittedName>
            <fullName evidence="4">Ubiquinone biosynthesis protein, putative (AFU_orthologue AFUA_4G06760)</fullName>
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        <name evidence="4" type="ORF">ANIA_04386</name>
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    <organism evidence="4 5">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
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            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
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    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. ADCK protein kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF77633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_661990.2">
        <property type="nucleotide sequence ID" value="XM_656898.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V8V7"/>
    <dbReference type="FunCoup" id="C8V8V7">
        <property type="interactions" value="470"/>
    </dbReference>
    <dbReference type="STRING" id="227321.C8V8V7"/>
    <dbReference type="GeneID" id="2872183"/>
    <dbReference type="KEGG" id="ani:ANIA_04386"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN4386"/>
    <dbReference type="eggNOG" id="KOG1235">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006533_2_5_1"/>
    <dbReference type="InParanoid" id="C8V8V7"/>
    <dbReference type="OMA" id="KVQYPWI"/>
    <dbReference type="OrthoDB" id="427480at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd13969">
        <property type="entry name" value="ADCK1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045307">
        <property type="entry name" value="ADCK1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051130">
        <property type="entry name" value="Mito_struct-func_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173:SF19">
        <property type="entry name" value="AARF DOMAIN-CONTAINING PROTEIN KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173">
        <property type="entry name" value="ABC1 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="97"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="ABC1 atypical kinase-like" evidence="3">
        <location>
            <begin position="207"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBF77633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="615" mass="70202" checksum="11D6FF9F12187647" modified="2009-11-03" version="1">MSGMRVALRTPLRALGDPASVLQYTASPYAPRELATWNSYKPPRYWLFSSLRFNKATFPQHNFRTPFSTKTLYRFETQQRAGGQGRQSQNSQSRNKWIGYGIIGGTIVVGGVVVSDDIRHIYHAAARTGRVVGTLAVCINDYRVTLKQETCTPEERNEAIRACHKRCADRTLHVLERNGSIFIKLGQHLSSMGYLLPLEWTTTFIPLQDKCPVSSVESIEQMFVKDTGKRIDELFTTFEPTPIGAASLAQVHIGTLKETGEKVAVKVQHPALAEWAPLDLALTRFTFSMLKRFFPEYDLEWLSKEMDLSLPQELDFRMEAQNAKRASEYFKKNSNAPLVIPKVLWAQKRILVMEFISGSRPDDLEYLDKNHIDRDEVSAALAHIFNEMIFGDNAPLHCDPHGGNIAIRKNPNRSRHNFDIILYDHGLYRDIPRETRRNYAKLWLSVIEADEARMREYSRKVAGVTDEQFPLFASAITGRDYTVLTKKNITSLRTEAEKESITGALGEGLLQQLVELLGQVPRIMLLILKTNDLTRSLDENLHTRQGPVRTFLILARYATRTVFEEQMDTINESGGLLRPSNFWQFLCAWTKFLRVELKLSVYETVLLLRSRLGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>C8V927</accession>
    <name>C8V927_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ANIA_11453</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF76421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467584.1">
        <property type="nucleotide sequence ID" value="XM_050611567.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V927"/>
    <dbReference type="GeneID" id="74897034"/>
    <dbReference type="KEGG" id="ani:ANIA_11453"/>
    <dbReference type="HOGENOM" id="CLU_3224556_0_0_1"/>
    <dbReference type="InParanoid" id="C8V927"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF76421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="44" mass="5237" checksum="475B0EB7E3B312E3" modified="2009-11-03" version="1">MSEHRVVFMPKDIIHTGHIAIEMMCKRESRSNRGMAERHKDENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>C8V9W5</accession>
    <name>C8V9W5_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_10616</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
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    <dbReference type="KEGG" id="ani:ANIA_10616"/>
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        <property type="component" value="Chromosome III"/>
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            <begin position="1"/>
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            <begin position="188"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="CBF76615.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="369" mass="40747" checksum="704E3B6D440263C4" modified="2009-11-03" version="1">MGESQSDFETEQPRTRHRKSAPPEPIIESSSESGTRHYLAPVTSRPDSRIAGSSISSVDYHERPLSLPDGRNTIHSPRAPLEGYFAHESPETFSVASLHQPLRGTASSDHIRLSDPTPTDPGRLSPRFPPYPPPVSPHRQPHVSSPRYSPSLPSPTPRTPPSRGRSEERTYAQELHLRSRSPKAFAPRPEERHLPKHDPTDPAFNLGAFRSSNPRTSRIGDQELPWKITIPGDDDDEAATSTSVSWSHETEGVLNGTGTGTDTSTRLPTYQEDEEEHGPSKFQPQDEKQGQPIPHPSSASEPTPPQAQPNTTTPDHPHRSGARTINALQGPVELPARTDDNSSEEIMMSSTAYPGQEWRPLGFSEWEDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>C8V9W6</accession>
    <name>C8V9W6_EMENI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">ANIA_10607</name>
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        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
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            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
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                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF76617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467607.1">
        <property type="nucleotide sequence ID" value="XM_050611594.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V9W6"/>
    <dbReference type="STRING" id="227321.C8V9W6"/>
    <dbReference type="GeneID" id="74896501"/>
    <dbReference type="KEGG" id="ani:ANIA_10607"/>
    <dbReference type="eggNOG" id="ENOG502SHV0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_351588_0_0_1"/>
    <dbReference type="InParanoid" id="C8V9W6"/>
    <dbReference type="OMA" id="RAHPEHM"/>
    <dbReference type="OrthoDB" id="5151921at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="507"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="622"/>
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    </feature>
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            <begin position="667"/>
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        </location>
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            <begin position="1"/>
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            <begin position="622"/>
            <end position="633"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF76617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="690" mass="73812" checksum="D9F56BA46C1D5E5E" modified="2009-11-03" version="1">MPTESPAASSSPTAPIVRPADIYKRMREEQQDRRPSPAAPSTDERASGGVTVLESSENTVPPAAQAPEPIYEAEQASVKKASTPPAASNDPPALSLPEVKRLSAFGSGFFSEPERDPQNNQEPGDQPHQLHHNPSLGFRSAVNQAFDVPETPSTVADSIARSNSDSTAGISPIIPRRGNTDDKTPTIHEEPNENTETPTEGNMVFKPGHRRDLSIPSPGNSPSRRPVVAGPDATASSELAQISSGSPVESPLATQPQQHVFNPDIPQPSREATRGDLPAPLNVQTNIVSNPAVSTDIPVIIPAMSTENSPEDTENDRLRKEIIRSLSRENSPSDNQENGTPPHTSGENNLLPREYEAHRAAPQTATSPGSEPSGPTFDTILATSQALSTGNLTPPPSHVSQPKLKKRFSWEESSEDEDPVPVTQAQPARPPPMPGQFPFSQDSVLPESVVAPTKQQSEIADASEERVGPPTPEKPKLTLVPPVAMDAPSIPLSDHGHEPALSQTTETLARAEEGDSSSHMPPTLERPTHTPPVSDETGLLGFKDILNMQSPYERIQSFDRTRDQFATINTGLGNWLQVTFHAHPEHHDVISRNSKPLSEEFKNSVPRTKFPKLASLGNLASSLQDGSHHSTSGHIRRPSAPLGSMRQQSGKDFLHTAGVLGGQAGKAAKGLFSKGRSKLKGAGGSEKVEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>C8VA31</accession>
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        <recommendedName>
            <fullName evidence="7">Actin associated protein Wsp1</fullName>
        </recommendedName>
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        <name evidence="5" type="ORF">ANIA_11104</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
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        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
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            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
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    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>C8VAJ3</accession>
    <name>C8VAJ3_EMENI</name>
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        <recommendedName>
            <fullName evidence="11">Phytanoyl-CoA dioxygenase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ANIA_11097</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PhyH family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF78397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467830.1">
        <property type="nucleotide sequence ID" value="XM_050611850.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VAJ3"/>
    <dbReference type="SMR" id="C8VAJ3"/>
    <dbReference type="FunCoup" id="C8VAJ3">
        <property type="interactions" value="13"/>
    </dbReference>
    <dbReference type="STRING" id="227321.C8VAJ3"/>
    <dbReference type="GeneID" id="74896781"/>
    <dbReference type="KEGG" id="ani:ANIA_11097"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN11097"/>
    <dbReference type="eggNOG" id="ENOG502RUKM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047725_0_1_1"/>
    <dbReference type="InParanoid" id="C8VAJ3"/>
    <dbReference type="OMA" id="GTRFIPG"/>
    <dbReference type="OrthoDB" id="445007at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE DOMAIN CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883:SF45">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBF78397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="320" mass="36603" checksum="8ADAE79F4D232923" modified="2009-11-03" version="1">MASSSKEDGSKVQYVAEGTPLEDIIGFMKRDGVVIVRQLVSPADIDQAYEEIRPCLEQRPRWNGSFFPKETQRTPNLIAISPTYTRTQMMNPLFHQLCNHFLTTRSWNWWGDEWSETVSRPYISATSALRVGPGAKAQPLHRDDYVSHNYIVESPMFNYRQQVSITMIVAGCKVTKENGGTQFIPGSHLWHVPTNYLGPEQFVDMFDRPNPPKVTDCTYASMEKGDALVLFSSLYHGGGHNTTTDEHRLVFTTCAIRGYFRQEENQYLAVPMQRVREYDRDTQKFIGYSMSEPACGHADEMDPIYLVHPEELETAEPIQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>C8VCC0</accession>
    <name>C8VCC0_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ANIA_11561</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF78412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467831.1">
        <property type="nucleotide sequence ID" value="XM_050611852.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VCC0"/>
    <dbReference type="GeneID" id="74897129"/>
    <dbReference type="KEGG" id="ani:ANIA_11561"/>
    <dbReference type="HOGENOM" id="CLU_2757770_0_0_1"/>
    <dbReference type="InParanoid" id="C8VCC0"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF78412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="70" mass="7789" checksum="B29E23EB723D9467" modified="2009-11-03" version="1">MTIMHHTPPKELNNINQIQDCRGLEEVSQVMGPWFQVKGVKHRTNPKLLGLTDLKLTKYCCLTGAGLAGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>C8VCG7</accession>
    <name>C8VCG7_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Zn(II)2Cys6 transcription factor (Eurofung)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ANIA_07379</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF78501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467838.1">
        <property type="nucleotide sequence ID" value="XM_050611859.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VCG7"/>
    <dbReference type="GeneID" id="2870033"/>
    <dbReference type="KEGG" id="ani:ANIA_07379"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN7379"/>
    <dbReference type="eggNOG" id="ENOG502QTSE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007003_4_3_1"/>
    <dbReference type="InParanoid" id="C8VCG7"/>
    <dbReference type="OMA" id="ITYLMGY"/>
    <dbReference type="OrthoDB" id="4161332at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051615">
        <property type="entry name" value="Transcr_Regulatory_Elem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF85">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="8"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="98"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBF78501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="742" mass="82974" checksum="B08471C696DD327B" modified="2009-11-03" version="1">MARRQKVVCSSCRHRKTKCDGASPSCSACVASASPCQYEKAPSLAYVRSLQARIRELEAKVKDSDSSPSAVVLSSVFNGHDGDSISFHAEGNLSYHNQTSAIHEGPPYTSRQLPQAAPQSPASRATQQSTDSIRHSLVANAVAQKNLELLNASAISPQADVPPEVTAILLQLHWCWLHPSFLFVYRPAFTRDMLQSAHHGQKPKYWSATLFKVLCAHSCRFIRAPEAFWSPEDYTESFSQFSNRLMSEAKALLALETLNPPSVPTIQALLQQSARDIACGRSSAAWLYSGMAFRMAIDLGLHVSPDDLQRHSTSLSAEDVEIRKRLFWSLYAWDKHISLYLGRMPNFTMGAENVSLEFLDDFTEEDLWEPYYGPEPASAERRSYPPTPGHIVSCFTQLCKLCILISRVMLDLYSPQPTSHPSSSLDARAAAFVTINRDLHEWYKALPSFLQIPSDKIPEISPPPHITSLNLMYHTTLILLHRPYVVSGHARDSDAARKSWKVCRSSTTTIYHLLQMYTKTFGFQHITYMNSYCTYTAATTAVYQLETSDGEPRVSDQVVWTELKFLLDILQRTSTTMPGLNRSIDIIRSRIKKILDRQVTKQLDSLFPGSNAPAGGQRYASPGPFRTQTVVGGEDLTTDHALDPTFPHPSSSFSPRRDLLTEDWRILDDWLPAFPGQDVSFGSEVVLDMPENLSPRTRSALMGSNLYPHMQLNFSMPDDPTFDYTPFSGTSSGPRPCDHHSL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-02-08" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>C8VCP9</accession>
    <accession>Q5AWM4</accession>
    <name>ATP25_EMENI</name>
    <protein>
        <recommendedName>
            <fullName>ATPase synthesis protein 25, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">atp25</name>
        <name type="ORF">AN10923</name>
    </gene>
    <organism>
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Probable mitochondrial mRNA stabilization factor.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ATP25 family.</text>
    </comment>
    <comment type="sequence caution" evidence="4">
        <conflict type="erroneous gene model prediction">
            <sequence resource="EMBL-CDS" id="EAA61357" version="1"/>
        </conflict>
        <text>AN7306 was demerged into AN10923 and AN10925.</text>
    </comment>
    <dbReference type="EMBL" id="AACD01000127">
        <property type="protein sequence ID" value="EAA61357.1"/>
        <property type="status" value="ALT_SEQ"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF78654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VCP9"/>
    <dbReference type="SMR" id="C8VCP9"/>
    <dbReference type="STRING" id="227321.C8VCP9"/>
    <dbReference type="EnsemblFungi" id="CBF78654">
        <property type="protein sequence ID" value="CBF78654"/>
        <property type="gene ID" value="ANIA_10923"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AN10923"/>
    <dbReference type="eggNOG" id="ENOG502S5IB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_272850_0_0_1"/>
    <dbReference type="InParanoid" id="C8VCP9"/>
    <dbReference type="OMA" id="CLSSWVP"/>
    <dbReference type="OrthoDB" id="107372at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140053">
        <property type="term" value="P:mitochondrial gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048255">
        <property type="term" value="P:mRNA stabilization"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.10:FF:000044">
        <property type="entry name" value="ATPase synthesis protein 25, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040152">
        <property type="entry name" value="Atp25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28087">
        <property type="entry name" value="ATPASE SYNTHESIS PROTEIN 25, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28087:SF1">
        <property type="entry name" value="ATPASE SYNTHESIS PROTEIN 25, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0809">Transit peptide</keyword>
    <feature type="transit peptide" description="Mitochondrion" evidence="2">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000404471" description="ATPase synthesis protein 25, mitochondrial">
        <location>
            <begin position="46"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="40"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="284"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="284"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="304"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="681" mass="76980" checksum="31848A44E77A0DC7" modified="2009-11-03" version="1" precursor="true">MTLLRAPQRFQYASRVFTSTSLSTPRHAYLTYSRVRSLTSTSHHPTKSHPSLSSSTSNTTSVEENDAPKSQCTPQASQHIPWYLQEESSVPAVSEVTLQEKLPELPENPPKILPELLEYIFKDLGLDELKLIDLRPLETPSALGANVIMIIGTARSVKHLNVSADRLCRWLRSEYKLSPYADGLLGRNELKIKLRRKNRRARIASRTGTMFDDKDDGITTGWICVNAGVVEEHPVEERVEGDFEGFGPLVGGTRVVVQVFTAEKRAEMDLETLWEGRLARAQRERQKHADAAKDDAPEEVRYPNSISPSPSDYKSPNVPRSWISLPHEQRRQFHIRSLRSFARPAHHAVFTPRFMSQNHTPAEHAIVGSELSSPTAMLLQYITTMPDQQLMSALGDRPDDESSTDFLRLFHHSLLGASPNVLALARLELLCLAHSRGHTGISKESVHRAFMGCCFSASHIPDRLIPTVVDILLTPRTGDNPDGEKWFTDADKELALSALDQLVLRGNDFMNLQFFTRLYYLSSLPPGPPGEENDDGLTPAERGAHVVRMIEILDIPFDPIHARTLMVYLFRNGDYDAFMKWWRTLPLKNSPRTREDYEMLFRLHADSGDSRLTRECISTWAPMMSREDPPIWLEGDLVAHLRDCLLLADERTPARAAEGTQSLFAKLWRACERELNKSEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>C8VDW6</accession>
    <name>C8VDW6_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ANIA_11574</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF80214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468059.1">
        <property type="nucleotide sequence ID" value="XM_050612105.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VDW6"/>
    <dbReference type="GeneID" id="74897140"/>
    <dbReference type="KEGG" id="ani:ANIA_11574"/>
    <dbReference type="HOGENOM" id="CLU_3368477_0_0_1"/>
    <dbReference type="InParanoid" id="C8VDW6"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF80214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="35" mass="3717" checksum="0A31E0C2DD500BF8" modified="2009-11-03" version="1">MNLAWLNRRIVISNPANNAVTGVAVPGAAIVWIKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>C8VE35</accession>
    <name>C8VE35_EMENI</name>
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        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
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    </protein>
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        <name evidence="8" type="ORF">ANIA_08342</name>
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    <organism evidence="8 9">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF80346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="XP_050468070.1">
        <property type="nucleotide sequence ID" value="XM_050612116.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VE35"/>
    <dbReference type="GeneID" id="2868824"/>
    <dbReference type="KEGG" id="ani:ANIA_08342"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN8342"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_0_1_1"/>
    <dbReference type="InParanoid" id="C8VE35"/>
    <dbReference type="OMA" id="WSYFTPR"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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    <dbReference type="GO" id="GO:0022857">
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        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF32">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="110"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="261"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="298"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="325"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="357"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="388"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="415"/>
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    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="19"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="CBF80346.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="456" mass="50287" checksum="556D354873A5E488" modified="2009-11-03" version="1">MRLFECLVRTDPSRLDTILIPILGLAFFALQIDRGNISAALTSSITEDLNITTNQINIGTQLLSAGIVISEIPSNVILQRVGPQRWLSAQLFAWGLVATFQAFIKSYPAYLVTRLLLGLLEGGFIPGALYYLSTWYKREETSLRVTLFFFGQMFSGATSSLISAGLLTLSGKRGLAGWRWIFLVEGAMTLFIGILFVLLVPPRAGDGRPLLSSFTGRWSYLTPRESHIATSRVLIDDPQKSAGHLKITGRDIWNTISRPRIIQHFFITLVAMSGFQGLTQYTPSMIKSFGFSAVRANALASVPVYCGMLWVLVLSYLSDKFGHRGPFVLISITWNVISYSCLRVTPATSGRWHRYGVIAVANVSYASMHVLNIGWLSVYCRSPQERSVALALVVMAANCAGISGSQIFRTEDKPLYLHGLTAICALAAASWVLALVLNLQNYFMHQGWKAKEAQGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>C8VEZ6</accession>
    <name>C8VEZ6_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">Glutamate synthase [NADH]</fullName>
            <ecNumber evidence="19">1.4.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="27" type="ORF">ANIA_05134</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="28" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="28">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="28" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="28">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="21">Forms L-glutamate from L-glutamine and 2-oxoglutarate. Represents an alternative pathway to L-glutamate dehydrogenase for the biosynthesis of L-glutamate. Participates with glutamine synthetase in ammonia assimilation processes. The enzyme is specific for NADH, L-glutamine and 2-oxoglutarate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>2 L-glutamate + NAD(+) = L-glutamine + 2-oxoglutarate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13753"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="1.4.1.14"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="24">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
        <text evidence="24">Binds 1 [3Fe-4S] cluster.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; L-glutamate biosynthesis via GLT pathway; L-glutamate from 2-oxoglutarate and L-glutamine (NAD(+) route): step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Energy metabolism; nitrogen metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Nitrogen metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the glutamate synthase family.</text>
    </comment>
    <dbReference type="EC" id="1.4.1.14" evidence="19"/>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF80924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468140.1">
        <property type="nucleotide sequence ID" value="XM_050612194.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="C8VEZ6">
        <property type="interactions" value="640"/>
    </dbReference>
    <dbReference type="STRING" id="227321.C8VEZ6"/>
    <dbReference type="GeneID" id="2871430"/>
    <dbReference type="KEGG" id="ani:ANIA_05134"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN5134"/>
    <dbReference type="eggNOG" id="KOG0399">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000422_8_2_1"/>
    <dbReference type="InParanoid" id="C8VEZ6"/>
    <dbReference type="OMA" id="WDGPAAM"/>
    <dbReference type="OrthoDB" id="4327079at2759"/>
    <dbReference type="UniPathway" id="UPA00045"/>
    <dbReference type="UniPathway" id="UPA00634">
        <property type="reaction ID" value="UER00690"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051538">
        <property type="term" value="F:3 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016040">
        <property type="term" value="F:glutamate synthase (NADH) activity"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016639">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019676">
        <property type="term" value="P:ammonia assimilation cycle"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006537">
        <property type="term" value="P:glutamate biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009064">
        <property type="term" value="P:glutamine family amino acid metabolic process"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097054">
        <property type="term" value="P:L-glutamate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00982">
        <property type="entry name" value="gltB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00713">
        <property type="entry name" value="GltS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02808">
        <property type="entry name" value="GltS_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000160">
        <property type="entry name" value="Glutamate synthase (NADPH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1060.10:FF:000006">
        <property type="entry name" value="Glutamate synthase (NADPH/NADH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000031">
        <property type="entry name" value="Glutamate synthase 1 [NADH]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000017">
        <property type="entry name" value="Glutamate synthase [NADH], amyloplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000113">
        <property type="entry name" value="Glutamate synthase [NADH], amyloplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000022">
        <property type="entry name" value="Glutamate synthase [NADH], amyloplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.60:FF:000001">
        <property type="entry name" value="Glutamate synthase, large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000001">
        <property type="entry name" value="Glutamate synthase, large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="entry name" value="Alpha-helical ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.60">
        <property type="entry name" value="Glutamate synthase, alpha subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028261">
        <property type="entry name" value="DPD_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002489">
        <property type="entry name" value="Glu_synth_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036485">
        <property type="entry name" value="Glu_synth_asu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006982">
        <property type="entry name" value="Glu_synth_centr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012220">
        <property type="entry name" value="Glu_synth_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002932">
        <property type="entry name" value="Glu_synthdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006005">
        <property type="entry name" value="Glut_synth_ssu1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051394">
        <property type="entry name" value="Glutamate_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01317">
        <property type="entry name" value="GOGAT_sm_gam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008730">
        <property type="entry name" value="PRK11750.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43100">
        <property type="entry name" value="GLUTAMATE SYNTHASE [NADPH] SMALL CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43100:SF1">
        <property type="entry name" value="GLUTAMATE SYNTHASE [NADPH] SMALL CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14691">
        <property type="entry name" value="Fer4_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00310">
        <property type="entry name" value="GATase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04898">
        <property type="entry name" value="Glu_syn_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01645">
        <property type="entry name" value="Glu_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01493">
        <property type="entry name" value="GXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000187">
        <property type="entry name" value="GOGAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00419">
        <property type="entry name" value="ADXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69336">
        <property type="entry name" value="Alpha subunit of glutamate synthase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46548">
        <property type="entry name" value="alpha-helical ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="18 24" id="KW-0003">3Fe-4S</keyword>
    <keyword evidence="8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0274">FAD</keyword>
    <keyword evidence="9" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-0288">FMN</keyword>
    <keyword evidence="17" id="KW-0314">Glutamate biosynthesis</keyword>
    <keyword evidence="13" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="15" id="KW-0408">Iron</keyword>
    <keyword evidence="16 24" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="26">
        <location>
            <begin position="53"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="961"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="1563"/>
            <end position="1587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="25">
        <location>
            <begin position="972"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="25">
        <location>
            <begin position="1577"/>
            <end position="1587"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="23">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="1184"/>
        </location>
        <ligand>
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="1190"/>
        </location>
        <ligand>
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="1195"/>
        </location>
        <ligand>
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00024383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00057049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00068518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PIRSR" id="PIRSR000187-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PIRSR" id="PIRSR000187-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="CBF80924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="2126" mass="234235" checksum="17F1FDEEBCC62A57" modified="2009-11-03" version="1">MGLNLEEIYGQTIVEEQRPNEYSEYQPKKGYGWANTLPERQGLYDPEYEKDACGVGFAANIKGKASHKIVSDARNLLCNMTHRGAVGSDARDGDGAGVMTSIPHKFFIKNFAREVGVDLPPLGQYAVGNLFFKPDEEALKESIKQFEEIATSLGLRVLGWREVPRDSTILGPAALSREPTILQPFVVLKSAYGEGNKPDITDPEQFDTKTFELQLYVLRKRATHIIGLANWFYLCSLSNRNIVYKGQLAPIQVYQYYHDLVNVDYEGHFALVHSRFSTNTFPSWDRAQPLRWAAHNGEINTLRGNKNWMRAREGLLKSDIFGEELESLLPIVEDGGSDSAAFDNVLELLMINGVLSLPEAVMIMIPEAWQDNPAMDPAKAAFYEWAACQMEPWDGPALFTFSDGRYCGANLDRNGLRPCRFYVTDDDRIICASEVGAVDIDQERVVQKGRLQPGKMLLVDTVAGRIIDDSELKYTVAHRHDFSSWLNKELVKLPAITEKLVEQNMDLRHDLDNTTVQNDPRLKAFGYSFEQVTLLLGPMGADSKEALGSMGNDAPLACIAKQPRLLYEYFRQLFAQVTNPPIDPIREAVVMSLECYVGPQGNLLEMDPSQCRRLLLPSPILSIPEFNALKNINTVHKDWTVRLIDITFEKKKGVPGYIEALDRICDAATEAIQQGDKILILSDRATSADRVPVSALLATGLVHHHLVRNKWRSLAALIVETAEAREVHHMCVLVGYGADGINPYLAMECILKMNREKLIRKELSDEKVIENYKASCDGGILKVMSKMGISTLASYKGAQIFEALGIDDSVIDRCFTGTASRIRGMNFELIAQDAFAIHERGYPSRAIVDIPGLNESGEYHWRDGGEDHINDPVSIANIQDAVRTKNDKSYEAYAKAAHEQIKNCTLRGMLEFDFDQRTPIPIDQVEPWTEIVRRFVTGAMSYGSISMESHSTLAVAMNRLGGKSNTGEGGEDPERSKRMENGDTMRSAIKQIASGRFGVTSHYLADADELQIKMAQGAKPGEGGELPGHKVVGPIAHTRYSTPGVGLISPPPHHDIYSIEDLKQLIYDLKCSNPRARVSVKLVSEVGVGIVASGVAKAKADHILISGHDGGTGASRWTGIKYAGLPWELGLAETHQTLVLNDLRGRVIVQTDGQIRTGRDVAVACLLGAEEFGFATTPLIAMGCIMMRKCHLNTCPVGIATQDPELRKKFEGQPEHVINFFYYIANELRAIMAKLGIRTINEMVGRAELLKVRDDLTNPKQENIDLSLILTPAHSLRPGVATYNVRKQDHRLHTRLDNKLIAESELALEKGLPCRVECDVVNTDRALGATLSYQVSRRYGGEGLPQDTIHSNIKGSAGQSFGAYLAPGITLELEGDANDYVGKGLSGGRLIVYPPRGAAFKAEENVIVGNTCLYGATRGTCFFRGVAAERFAVRNSGATAVVEGVGDHGCEYMTGGRVVVLGSTGRNFAAGMSGGIAYILDMNQDFLSKVNMEMVECSGLEDPAEIAFLRGLIEDHHHYTGSELAARILLDFTRALPHFIKVLPTDYKRTLEEEAAKAAAAKKAETTIPQLPSVPVEKQKPKAEGDAKKAELLDIEDSVTDSKVEKKRTALILDKTRGFMKYNRRSEKYRNPATRTRDWAELSSRLTEDELKYQSARCMDCGVPFCQSDTGCPISNIIPKWNELVFQNQWQDALNRLLMTNNFPEFTGRVCPAPCEGACVLGINEDPVGIKSIECAIIDRGFEMGWMVPRPPPVRTGKTVAIIGSGPAGLAAADQLNRVGHSVTVYERADRIGGLLMYGIPNMKLDKKIVQRRVDLMAAEGVKFVTGVSVGPDSEVSLDSLRKSNDAVIIATGATVARDLKVPGRELEGIHFAMQFLHKNTKSLLDSELADGAYISAKDKHVVVIGGGDTGNDCIGTSVRHGAKSVVNFELLPQPPPERARDNPWPQWPRIYRVDYGHSEVKTHMGKDPREYCIMSKEFVDDGNGRVKGINTVRVEWTKSATGGWDMKTVEGSEQFFPADLVLLSMGFLGPEDRLLGEEIERDARKNVKTPPGHYGTNVPGVYAAGDCRRGQSLIVWGINEGRQCAREVDTFLSGISSQLPVTGGIVRRPAVDAVRQATETVTIAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2025-10-08" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>C8VJ57</accession>
    <name>C8VJ57_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peroxisomal ATPase PEX6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Peroxin-6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">ANIA_02925</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Interacts with PEX1; forming the PEX1-PEX6 AAA ATPase complex, which is composed of a heterohexamer formed by a trimer of PEX1-PEX6 dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Peroxisome membrane</location>
            <topology evidence="7">Peripheral membrane protein</topology>
            <orientation evidence="7">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF83738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_660529.2">
        <property type="nucleotide sequence ID" value="XM_655437.2"/>
    </dbReference>
    <dbReference type="FunCoup" id="C8VJ57">
        <property type="interactions" value="270"/>
    </dbReference>
    <dbReference type="STRING" id="227321.C8VJ57"/>
    <dbReference type="GeneID" id="2874411"/>
    <dbReference type="KEGG" id="ani:ANIA_02925"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN2925"/>
    <dbReference type="eggNOG" id="KOG0736">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000688_0_2_1"/>
    <dbReference type="InParanoid" id="C8VJ57"/>
    <dbReference type="OMA" id="KIMLCEP"/>
    <dbReference type="OrthoDB" id="5553750at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016558">
        <property type="term" value="P:protein import into peroxisome matrix"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006625">
        <property type="term" value="P:protein targeting to peroxisome"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043335">
        <property type="term" value="P:protein unfolding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd19527">
        <property type="entry name" value="RecA-like_PEX6_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000108">
        <property type="entry name" value="Peroxisomal biogenesis factor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000109">
        <property type="entry name" value="Peroxisomal biogenesis factor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000039">
        <property type="entry name" value="peroxisome biogenesis factor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056995">
        <property type="entry name" value="PEX6_4th_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047533">
        <property type="entry name" value="RecA-like_PEX6_r2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF9">
        <property type="entry name" value="PEROXISOMAL ATPASE PEX6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23315">
        <property type="entry name" value="PEX6_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23120">
        <property type="entry name" value="PEX6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="13">
        <location>
            <begin position="1057"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="302"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="390"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1321"/>
            <end position="1341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1359"/>
            <end position="1476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="395"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1321"/>
            <end position="1330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1386"/>
            <end position="1434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="1448"/>
            <end position="1457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1458"/>
            <end position="1470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00062700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CBF83738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="1476" mass="158903" checksum="F5BA6BD07160C114" modified="2009-11-03" version="1">MDLERHEFSSDQSIRRRRNFARKRLRNKTALSARLSLDHRLRGSVGVVSDDLANDLFQPPDPTDDFQDDSGIRYIAISPYLPGPSSVEALTWTIVPVRPQSAGRSNESPLPKSTIIFPDSADSLQPFVRALSKLDPTRQSPHTLRLIEIRVMDVVPLPLDTIYVTVERDLLRNHDDVQSRFGGGFTSNMNGPNGLWAKGKGAESKKYSKKAAAEVEGRLTAAVREALGTQRVVHTGDSLPLPLPPHPITYAPAPPALISFCEPVSQGLLLPTTKIVLIQARPHGNRAQRSLRPASGFLKQVAEDEADDTSNEQFYSAAEDKPVDDSTEMESTSNAEESETEGSGGNTSDTSDDSLDDMISLSAPELPQPATGVMSGMTSATPRARRMDGIHTPGSMVSNLTSSTLRPGRQGGGKVFKAEGLLRRVPNELLYPKPRDDDDVEAVVFVDISTLAKIGCFSGDWVRIEASEEPQANIFSSINLGSFNEQYGEGDWRAVKIYGLPGLPSAKPRYSIKQSGDRRLSFSQRPGVRMTPSVFVPPLLLNNMDNPRYLRISPMSLGGIGVPKSGVLHQMKTAARSPPVAKEVTLLKVSTPVSMDRALQPALFSALKQYFESKRRLLKSGDLLGISIDETLGRAVFAGTGADGQDDDITTKLGPGLDTNRAGPKKIGVAWFRVGQVIPSLPEDQDDFGEFDWGGVAVIDSATTRMVQAGSDVSRIPNTLNNGWEYWLGTKSIPKPVVDTQTIHGVVTEVPQPFVSPIQQRVRDLMAVATSSRAIQLGMKPVVILLRSQQRHIGKASLATRACAEIGLHTFPIDAYDILTEGGANGGDVKTEAYLKARAERAFHCGADCTALLIKHIEVLTADRIVSAMTEILADARVIIATTTDVEQIPEAIRSMFTHEFELTAPEEKEREGILRNAVSERSIKLAPDVDLGTVALKTAALVAGDLVDVVERASVARSTRLEKLAESASKQSPTSKITVRDVLLAGGEAVRGVTKADFDAAVDAARKNFADSIGAPKIPNVSWEDVGGLTNVKDALVETIQLPLERPELFAKGMKKRSGILFYGPPGTGKTLLAKAIATEFSLNFFSVKGPELLNMYIGESEANVRRVFQRARDARPCVVFFDELDSVAPKRGNQGDSGGVMDRIVSQLLAELDGMNGGEENSGGVFVIGATNRPDLLDTALLRPGRFDKMLYLGVSDTHEKQATILEALTRKFALAPDLSLARVSERLPLTYTGADLYALCSDAMLKAITRKATAVDEKIKQLPGGPVSTAYFFDHLSTPDDVAVMVTEEDFVAAQSELVPSVSAKELEHFERIRQMFESTDKDKQKQDANPAPTPNTIGDAIEALKLGHDINGYIGDPVTNGGDQPLSPTGTGKGKGKQPAYGSMRSVSGQSVSSSRGKGKAATSGGKSSLKSKSVSAANGNADSDSSLDGPLMGSGARGGVNSDGDDDDDDNDYIVRTDHLAKTDADGEDVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>C8VJA2</accession>
    <name>C8VJA2_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_02881</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF83819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468512.1">
        <property type="nucleotide sequence ID" value="XM_050612604.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VJA2"/>
    <dbReference type="GeneID" id="2874087"/>
    <dbReference type="KEGG" id="ani:ANIA_02881"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN2881"/>
    <dbReference type="eggNOG" id="ENOG502RZ1N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025462_2_0_1"/>
    <dbReference type="InParanoid" id="C8VJA2"/>
    <dbReference type="OMA" id="TYRYPIQ"/>
    <dbReference type="OrthoDB" id="5043642at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021848">
        <property type="entry name" value="HODM_asu-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11927">
        <property type="entry name" value="HODM_asu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF83819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="441" mass="50384" checksum="B1F14D625514EE2D" modified="2009-11-03" version="1">MPTLDFVLARTPLVAFLTIFICFFVIYIRRKPNASRNHGVESPSPYPGKEAKQSRFGYPPVTPLPSFNWETTEPLVFRPFKPKFHLTMAITHLDLSDLIPMDKTYLSRLSLREKLLAEHPDVVRGVNIHTQNPTKNEKIREALCEWYAYVMGTYLPERYPTMFRLVDHLGTGNVKSEKMRKMMIESLVTGLKAPVDPEDLMRFCPTNIEDEDDTARTKTQLLYLLDTLGSWIDEDFLILLPSPVPPPSFEDHSSESDPELKSQYHLEAYTTYYPAGFDTRKKLSLSLSAIHAPLPGYKQKLSKSMDRFFERLEVGKAVVRVNWSIMPKGTGLFAAFGGLHNHSPNAERGNEKVEKLHPESFDGEDTFLRCERQTLHRLPNSKALLFAFHTYTYPLKDVKEEGLGEELAIAIDGLKEGSVPEIHEYKNGPYWGEAVKAFLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>C8VQB3</accession>
    <name>C8VQB3_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Intradiol ring-cleavage dioxygenases domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ANIA_09268</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
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            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
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        <property type="entry name" value="INTRADIOL RING-CLEAVAGE DIOXYGENASES DOMAIN-CONTAINING PROTEIN-RELATED"/>
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        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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        </lineage>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
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            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CBF90236.1"/>
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        <property type="nucleotide sequence ID" value="XM_050611076.1"/>
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        <source>
            <dbReference type="EMBL" id="CBF90236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="62" mass="7058" checksum="3723651F6A7E52B9" modified="2009-11-03" version="1">MVTGAPAGVWHDAESSRFIRLGFDDPQDFSICSMISFFSYLFFAPYIPAQVPFLINYPSLYL</sequence>
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    <reference evidence="8" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
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            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF90247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050469343.1">
        <property type="nucleotide sequence ID" value="XM_050611078.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VR01"/>
    <dbReference type="STRING" id="227321.C8VR01"/>
    <dbReference type="GeneID" id="2875857"/>
    <dbReference type="KEGG" id="ani:ANIA_00077"/>
    <dbReference type="eggNOG" id="KOG0143">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010119_6_2_1"/>
    <dbReference type="InParanoid" id="C8VR01"/>
    <dbReference type="OMA" id="FTTRHDP"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044283">
        <property type="term" value="P:small molecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10209">
        <property type="entry name" value="OXIDOREDUCTASE, 2OG-FE II OXYGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10209:SF886">
        <property type="entry name" value="UPF0676 PROTEIN C1494.01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="6">
        <location>
            <begin position="145"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBF90247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="338" mass="36779" checksum="DA2E3924DDA162B9" modified="2009-11-03" version="1">MAEPTPAGTSIELPILDISNPEDPAVGEAMLDAATKYGFLYVDSKGTDFTAEDVRKAFERSKSFFASPVEEKEASRIQSNNRGWSGMHSETLDPEHQRTGDFKEAFNFGEFTAEGKAQQPLPPALAPHEAEIADFASLCTKTCNRILSLLSLGLKTADYDHTVDVRAGAHSDYGSITLLFQRPGQPGLEILTPEGTWAPVAVEPGRPSPSGDDVNNEFAFPPILVNIGDLLSYWTDGLLKSTVHRVVFPASERTGNSSQDRYSIVFFCHPVDSTELVPVPSDVVKAYREEKVVDAEERVGFGGGAGNLEPGRRTLTAAEHLAMRLNATYDFRQEATVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>C8VR17</accession>
    <name>C8VR17_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PH domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_00061</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF90277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050469346.1">
        <property type="nucleotide sequence ID" value="XM_050611082.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VR17"/>
    <dbReference type="FunCoup" id="C8VR17">
        <property type="interactions" value="39"/>
    </dbReference>
    <dbReference type="STRING" id="227321.C8VR17"/>
    <dbReference type="GeneID" id="2875838"/>
    <dbReference type="KEGG" id="ani:ANIA_00061"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN0061"/>
    <dbReference type="eggNOG" id="ENOG502S45T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067862_1_1_1"/>
    <dbReference type="InParanoid" id="C8VR17"/>
    <dbReference type="OMA" id="CNFCGIR"/>
    <dbReference type="OrthoDB" id="2103474at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025187">
        <property type="entry name" value="DUF4112"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35519">
        <property type="entry name" value="MEMBRANE PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35519:SF2">
        <property type="entry name" value="PH DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13430">
        <property type="entry name" value="DUF4112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="75"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF90277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="237" mass="26687" checksum="696729BB9E3FC519" modified="2009-11-03" version="1">MSFLFSFVGKKILAESARNHFGQEDPYFEEVPASRLGRAFGKKTQKRRKAIPPGLSENDSKVLTRVKRRAYRLDLALFSLCGLKFGWGSVIGLIPFIGDAADAALAMMVLKTCEGIDGGLPTWLRTRMTINIIIDFLIGLVPFVGDIADAAYKCNTRNAIALEKYLREKGARNISRQERTDVDPSLPDEFDRYDREAHTEHATEPRRSKSRKGHPRKSTRGEEDLESGIVEDRSGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2025-10-08" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>C8VRD4</accession>
    <name>C8VRD4_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">LSM complex subunit LSM3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LSM3</name>
        <name evidence="12" type="ORF">ANIA_10007</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Binds specifically to the 3'-terminal U-tract of U6 snRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the heptameric LSM1-LSM7 complex, which consists of LSM1, LSM2, LSM3, LSM4, LSM5, LSM6 and LSM7. Component of the heptameric LSM2-LSM8 complex, which consists of LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8. The LSm subunits form a seven-membered ring structure with a doughnut shape.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">LSm subunits form a heteromer with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF90306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VRD4"/>
    <dbReference type="FunCoup" id="C8VRD4">
        <property type="interactions" value="519"/>
    </dbReference>
    <dbReference type="STRING" id="227321.C8VRD4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN10007"/>
    <dbReference type="eggNOG" id="KOG3460">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076902_5_0_1"/>
    <dbReference type="InParanoid" id="C8VRD4"/>
    <dbReference type="OMA" id="FDSHCNI"/>
    <dbReference type="OrthoDB" id="29543at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140445">
        <property type="term" value="C:chromosome, telomeric repeat region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990726">
        <property type="term" value="C:Lsm1-7-Pat1 complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005732">
        <property type="term" value="C:sno(s)RNA-containing ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008266">
        <property type="term" value="F:poly(U) RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070034">
        <property type="term" value="F:telomerase RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030620">
        <property type="term" value="F:U2 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033962">
        <property type="term" value="P:P-body assembly"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01730">
        <property type="entry name" value="LSm3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000036">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034105">
        <property type="entry name" value="Lsm3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040002">
        <property type="entry name" value="Sm-like_LSM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13110">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10 12" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 10" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="11">
        <location>
            <begin position="14"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CBF90306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="96" mass="10813" checksum="C8A3FCA1874A6360" modified="2009-11-03" version="1">MADTEGAGTSSVSEPLDLVRLSLDEIVFVKLRGDRELKGRLHAYDSHCNLVLGDVEETIYVVEEDENEQEHIRTIKKQEEMLFVRGDSVVLISPQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>C8VSF9</accession>
    <name>C8VSF9_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">VPS9 domain protein, putative (AFU_orthologue AFUA_1G09870)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ANIA_01280</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0507 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF87803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_658884.2">
        <property type="nucleotide sequence ID" value="XM_653792.2"/>
    </dbReference>
    <dbReference type="GeneID" id="2877056"/>
    <dbReference type="KEGG" id="ani:ANIA_01280"/>
    <dbReference type="eggNOG" id="ENOG502R3ZQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002294_0_0_1"/>
    <dbReference type="InParanoid" id="C8VSF9"/>
    <dbReference type="OMA" id="HFPMIAR"/>
    <dbReference type="OrthoDB" id="7464126at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030133">
        <property type="term" value="C:transport vesicle"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097422">
        <property type="term" value="C:tubular endosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045022">
        <property type="term" value="P:early endosome to late endosome transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd06093">
        <property type="entry name" value="PX_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000443">
        <property type="entry name" value="Putative vps9 domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.80:FF:000009">
        <property type="entry name" value="VPS9 domain protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000058">
        <property type="entry name" value="VPS9 domain protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.80">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051248">
        <property type="entry name" value="UPF0507/Ank_repeat_27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003123">
        <property type="entry name" value="VPS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037191">
        <property type="entry name" value="VPS9_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24170">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24170:SF1">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G09870)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13857">
        <property type="entry name" value="Ank_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02204">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109993">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51205">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VPS9" evidence="3">
        <location>
            <begin position="394"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="212"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="269"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBF87803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="1344" mass="149703" checksum="5E4C6A409AAF2720" modified="2009-11-03" version="1">MPGACRHQETAGFEDDNHFATDGVVIKILITFAQAHDCILRLSTLSLDFGLLAGQMRLSLPTVDPPANVPFYLLQRAVVQDRLDAPSKSFSPGFLSEHCAGAVLLVPVSESLIGSRDRESSLLYSDLVVSEEFLGSHTLRIPASSGAGGRDDSNVRDGRGFKSLSQAQLLSDALYYAPTGESQPWLIYYISRPLVGSFEPAKIIPAIVPGTGSRVDPSQASAKPGETAGTISTPPKKEIRTFGELLANFPMIARQMQPGLERLFREFGKELGKPLPPPPSRSPMLDDNESGRVREESIADENGSIKSSSSRRSKGLPFNSEEYFEDDEDLMRRSLETAVTAAIDLFRLVDQQQLSLLGATTDLTGPVVERYIERYVAEQVHESLLFPRLCSFRQPEDIELDARIRQMEYVDVSQVGLVVEGGRDGKRELLLRLGRAVEEFRKMLDAKCPHDMLNTLLETVKVLSYPGEYNKSDEKQSAPVTINADILVSLLLIVVIRSQVKNLQARLLYMQHFIYVDDVDSGEMGYALSTFEAVLTYLMADPAGLRRASIRNKRLWNATKAGRVADMKAILEPDGYHESFFEAYDAADSQEQPLDEGQPNRDSQRMLPLFGDQIQTRDEGLEAASEAPPLAHVFPFQTWEASSPRDTKPPIKRVSMDVRSLSESSGISFLSRTTTLNSISSAIEGDSSIETLVKTQDPHGDSILMMAVESRRAEALKYLLSLGEYYSVTDVLEDTNTDGTTLLSAAVQLAQTEIVDLLLDYLTAAADEGAITSYLRKFDERGRTAAHYLFSTPAVMRRLKGLLPWRQRDKLGQTPLFALCRSYDHPEYKAMVNEALTAAQESQGDGEPLHLDDHVDSRGNTLLHIVSDPEITIRILRESDCDPNATNDKKFTPLMMASKYGRVDQVRILFSDSRVDHHLKESRGLTAIELAKDDEVRNRIDDLILLSNPPSSHDESSGRVTTVVRSFFVEDATVRFVLKSGAPTPPIDGQDVPAHTTMYTVTTCRRTLSDFETLAECLSLEHPASYMPSLTDFRNPFQIHSKPSRAVLHNMQERLDRFLKILLSHPTFSTHELLWEFILVPELQPQMMADRSHRKAQALSESIIEDHDPITSEGIREAEQFISHAQDMVHATHTHTRSLLRRGHALQNATSDIADAVALAASVFSTLKYSTNALPPSHVDAFSRYASYLSTSTSDSSPLLQFLSTLSSIDTTTSAILSSLSRPLSLIASLNSSTRTLTRSRNALASSSLPRKFNLNFPGLEESRLRSLRDLQEKITNSEDQIARLSREISWNKDVVVGELAGWTSWREQVGRGAIRDFVRSTLVREKERKRRLERCLRSVRDVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>C8VST7</accession>
    <name>C8VST7_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Stress-response A/B barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_01204</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF87939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050469020.1">
        <property type="nucleotide sequence ID" value="XM_050613187.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VST7"/>
    <dbReference type="GeneID" id="2876980"/>
    <dbReference type="KEGG" id="ani:ANIA_01204"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN1204"/>
    <dbReference type="eggNOG" id="ENOG502S73V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080664_2_1_1"/>
    <dbReference type="InParanoid" id="C8VST7"/>
    <dbReference type="OMA" id="GIQNGMT"/>
    <dbReference type="OrthoDB" id="1601230at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013097">
        <property type="entry name" value="Dabb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044662">
        <property type="entry name" value="HS1/DABB1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33178">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33178:SF10">
        <property type="entry name" value="STRESS-RESPONSE A_B BARREL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07876">
        <property type="entry name" value="Dabb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00886">
        <property type="entry name" value="Dabb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51502">
        <property type="entry name" value="S_R_A_B_BARREL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Stress-response A/B barrel" evidence="2">
        <location>
            <begin position="3"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF87939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="110" mass="12243" checksum="BAE46A63F34ED399" modified="2009-11-03" version="1">MPITHIVMFQVKQGLSAETVNDLCLRMLSLKDKCIHPVSQKPYIISSSGGIDNSPEGMQNGITHAFVVEFANEEDRAYYLEKDPAHLEFVGSLKDVIEKAQVVDFTNGVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2025-10-08" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>C8VUY4</accession>
    <name>C8VUY4_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Oxidoreductase, short chain dehydrogenase/reductase family (AFU_orthologue AFUA_5G11240)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ANIA_00179</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF90029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_657783.2">
        <property type="nucleotide sequence ID" value="XM_652691.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VUY4"/>
    <dbReference type="FunCoup" id="C8VUY4">
        <property type="interactions" value="559"/>
    </dbReference>
    <dbReference type="STRING" id="227321.C8VUY4"/>
    <dbReference type="GeneID" id="2875960"/>
    <dbReference type="KEGG" id="ani:ANIA_00179"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN0179"/>
    <dbReference type="eggNOG" id="KOG1205">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_2_10_1"/>
    <dbReference type="InParanoid" id="C8VUY4"/>
    <dbReference type="OMA" id="WRWMWET"/>
    <dbReference type="OrthoDB" id="6251714at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097308">
        <property type="term" value="P:cellular response to farnesol"/>
        <property type="evidence" value="ECO:0000270"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05346">
        <property type="entry name" value="SDR_c5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000047">
        <property type="entry name" value="NADP-dependent L-serine/L-allo-threonine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42901">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42901:SF1">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBF90029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="313" mass="34143" checksum="3A73BACFC41B24A8" modified="2009-11-03" version="1">MFFNRAYHQSIAVLRQFASPYPRISAFPRPLTSVLGSSFRRTMASAMAKRLEGKTIVITGASSGIGRSTAREFARTAPKDLKLIVTARRIDALEELAKEIKEEVGEGVKTLPVKLDVSNPEEVKNFVPSLPAEFQDIDILVNNAGLVKGVAQAPNIDPEDINIMFATNVTGLINLTQAVLPIFKKRSDGGRGDIINIGSIAGREPYPGGSIYCSTKAAVKSFTEALRKELISTRIRVIEIDPGQVETEFSIVRFYGDKSKANAVYANCEPLTPDDIAEVIVFAAGRRENVVIADTLIFPSHQASPGHLYKKPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-12-14" modified="2025-10-08" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>G5EB61</accession>
    <accession>C8UZU2</accession>
    <name>G5EB61_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Dihydroorotate dehydrogenase (quinone), mitochondrial</fullName>
            <ecNumber evidence="5">1.3.5.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Dihydroorotate oxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">ANIA_05909</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="16">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(S)-dihydroorotate + a quinone = orotate + a quinol</text>
            <dbReference type="Rhea" id="RHEA:30187"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
            <dbReference type="ChEBI" id="CHEBI:30864"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.3.5.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; orotate from (S)-dihydroorotate (quinone route): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.2" evidence="5"/>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF70590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_663513.1">
        <property type="nucleotide sequence ID" value="XM_658421.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G5EB61"/>
    <dbReference type="SMR" id="G5EB61"/>
    <dbReference type="STRING" id="227321.G5EB61"/>
    <dbReference type="GeneID" id="2870902"/>
    <dbReference type="KEGG" id="ani:ANIA_05909"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN5909"/>
    <dbReference type="eggNOG" id="KOG1436">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013640_4_0_1"/>
    <dbReference type="InParanoid" id="G5EB61"/>
    <dbReference type="OMA" id="IYGTDTR"/>
    <dbReference type="OrthoDB" id="14784at2759"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00946"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004589">
        <property type="term" value="F:dihydroorotate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106430">
        <property type="term" value="F:dihydroorotate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004152">
        <property type="term" value="F:dihydroorotate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009220">
        <property type="term" value="P:pyrimidine ribonucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd04738">
        <property type="entry name" value="DHOD_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000242">
        <property type="entry name" value="Dihydroorotate reductase PyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050074">
        <property type="entry name" value="DHO_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005719">
        <property type="entry name" value="Dihydroorotate_DH_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005720">
        <property type="entry name" value="Dihydroorotate_DH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001295">
        <property type="entry name" value="Dihydroorotate_DH_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48109:SF4">
        <property type="entry name" value="DIHYDROOROTATE DEHYDROGENASE (QUINONE), MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48109">
        <property type="entry name" value="DIHYDROOROTATE DEHYDROGENASE (QUINONE), MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01180">
        <property type="entry name" value="DHO_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00911">
        <property type="entry name" value="DHODEHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0288">FMN</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dihydroorotate dehydrogenase catalytic" evidence="14">
        <location>
            <begin position="145"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="433"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CBF70590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="520" mass="54816" checksum="CA72C01F546B3E84" modified="2011-12-14" version="1">MATNSFRKLTFSGASRLGGCRRLPLTCRQLRFASDSGAAAATTKATAESAAESASINVKEAPKKAGRGLRRTVLGTSLALTLLVGYVYGTDTRASVHRYGVVPLIRALYPDAEDAHHIGVDTLKMLYKYGLHPRERGDPDGDGALATEVFGYTLSNPIGISGGLDKHAEIPDPLFAIGPAIVEVGGTTPLPQDGNPRPRVFRLPSQRAMINRYGLNSKGADHMAAILEQRVRDFAYANGFGAYDAAKQRVLDGEAGVPPGSLQPGKLLAVQVAKNKATPDGDIEAIKRDYVYCVDRVAKYADILVVNVSSPNTPGLRDLQATAPLTAILSAVVGAAKSVNRKTKPYVMVKVSPDEDSDEQVSGICDAVRASGVDGVIVGNTTNRRPDPIPQGYTLPAKEQATLKETGGYSGPQLFDRTVALVARYRSMLDAESETAGSAKDSAATIAQTEPGSENVPPVEAPSGLPRKVIFASGGITNGKQAHAVLDTGASVAMMYTGVVYGGVGTVTRVKQELRTAKKE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1993-10-01" modified="2026-01-28" version="120" xmlns="https://uniprot.org/uniprot">
    <accession>P33144</accession>
    <accession>C8V9Q5</accession>
    <accession>Q5ASE7</accession>
    <name>BIMB_EMENI</name>
    <protein>
        <recommendedName>
            <fullName>Separin</fullName>
            <ecNumber>3.4.22.49</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Cell division-associated protein bimB</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Separase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">bimB</name>
        <name type="ORF">AN8783</name>
    </gene>
    <organism>
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1992" name="J. Biol. Chem." volume="267" first="15737" last="15743">
            <title>The bimB3 mutation of Aspergillus nidulans uncouples DNA replication from the completion of mitosis.</title>
            <authorList>
                <person name="May G.S."/>
                <person name="McGoldrick C.A."/>
                <person name="Holt C.L."/>
                <person name="Denison S.H."/>
            </authorList>
            <dbReference type="PubMed" id="1639810"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>A773</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text>Required for nuclear division. Could function in the mitotic spindle.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>All bonds known to be hydrolyzed by this endopeptidase have arginine in P1 and an acidic residue in P4. P6 is often occupied by an acidic residue or by a hydroxy-amino-acid residue, the phosphorylation of which enhances cleavage.</text>
            <dbReference type="EC" id="3.4.22.49"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location>Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="sequence caution" evidence="3">
        <conflict type="frameshift">
            <sequence resource="EMBL-CDS" id="AAA33297" version="1"/>
        </conflict>
    </comment>
    <comment type="sequence caution" evidence="3">
        <conflict type="frameshift">
            <sequence resource="EMBL-CDS" id="CBF78027" version="1"/>
        </conflict>
    </comment>
    <comment type="sequence caution" evidence="3">
        <conflict type="frameshift">
            <sequence resource="EMBL-CDS" id="EAA60576" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EC" id="3.4.22.49"/>
    <dbReference type="EMBL" id="M83232">
        <property type="protein sequence ID" value="AAA33297.1"/>
        <property type="status" value="ALT_FRAME"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AACD01000161">
        <property type="protein sequence ID" value="EAA60576.1"/>
        <property type="status" value="ALT_FRAME"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF78027.1"/>
        <property type="status" value="ALT_FRAME"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="A42854">
        <property type="entry name" value="A42854"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_682052.1">
        <property type="nucleotide sequence ID" value="XM_676960.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P33144"/>
    <dbReference type="SMR" id="P33144"/>
    <dbReference type="STRING" id="227321.P33144"/>
    <dbReference type="KEGG" id="ani:ANIA_08783"/>
    <dbReference type="eggNOG" id="KOG1849">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000454_0_0_1"/>
    <dbReference type="InParanoid" id="P33144"/>
    <dbReference type="OrthoDB" id="10255632at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051307">
        <property type="term" value="P:meiotic chromosome separation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005314">
        <property type="entry name" value="Peptidase_C50"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030397">
        <property type="entry name" value="SEPARIN_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12792">
        <property type="entry name" value="EXTRA SPINDLE POLES 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12792:SF0">
        <property type="entry name" value="SEPARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03568">
        <property type="entry name" value="Separin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51700">
        <property type="entry name" value="SEPARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0132">Cell division</keyword>
    <keyword id="KW-0159">Chromosome partition</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0498">Mitosis</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-0645">Protease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0788">Thiol protease</keyword>
    <feature type="chain" id="PRO_0000205902" description="Separin">
        <location>
            <begin position="1"/>
            <end position="2067"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C50">
        <location>
            <begin position="1880"/>
            <end position="1975"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="51"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="140"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1316"/>
            <end position="1363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1449"/>
            <end position="1478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="55"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1333"/>
            <end position="1354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1449"/>
            <end position="1461"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="1964"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; AAA33297." evidence="3" ref="1">
        <original>S</original>
        <variation>P</variation>
        <location>
            <position position="512"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; AAA33297." evidence="3" ref="1">
        <original>A</original>
        <variation>R</variation>
        <location>
            <position position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="2067" mass="227831" checksum="3D711A90E1C0E38E" modified="2009-05-26" version="2">MAVTSFPADSLASMESVKQTVRSTSTCSAATVLSLQTLFRSAGEMETTLRRTARGTKATATNATASSRAKTTRTKSTSTSTTRTKTPAQDVSTFTSTSASLADTRLSNQEKLVLATEVFNSTLKTLSDAVKTVMSISKEKKDASPTKRGTTTKGRVKTSQPDLTDNENGVSAVAECARLSLSCLRMLRTDAMVDGGLPNLQLEQGACVLAGRLLALGLNDAAYKELRGLKRRIQSYLEELPSGRKRTGRKDAEDGEETAKERMSDLLSFSDIANARSIHGLLVSFQSNALRLIAAEKRPATVQKLVPSLQLTDESSPANVIMASIDSGALTKDKAAVQLQLLSSTVLSLSASGASTGKERLRPSIVLSLQLLALEIRCMSWKLSGHACEDNKEMWDPLARYIGAFAQATKSIEKAEFAVIYKNIVRLQSAFSKTQNCATRSTDNLSVARIATILGQLAQDAGCFDEALQLFTESLNPLSSSQCLGMATVRCKIAALHFQAFKSSVKLPGDVSDAVSQATAALSISLKGSSHDLDELLVQAAKLKKLAMGWFGDLISKGQGSQCENVVFPRICEFLSSFVRFLRRYIGRRPENDELNDREIFQKRIDAAQNIVLAAVDSTIAIGKLSVMSQRPAWEETVSTLLDCQRLLATIEPFDEVDVATADSIDQALVKLSNLFWSRYLKEKEAGKNARELLPLLKQSAYLLSGCSPSQRATGFAPLKYERLAHTYIEGNMVSEAEVAFRQSITDHIAAGALDKIASSTDGCFPHQMNQDPKRSGFTLGRVLSAYLKVKLRNKRSAVNEIFDDETLPSVQRGHVLEWQLGILTEIHGTSNNDNVFRSVFAEVATRLFKVYPAEQHPVRRLRVLLSGLRFALEQPGFLDSSLLQRFADEGRKGLDDDDYQDDDDIKSLAVYLKNSVRLTLGLQQGSLGPEELELIVSTWTSILRFCHDLKSLVACVGNVEYFLLQMKAVVDYTEIHGLWKFQLSTLELVLRVTELHGAGTFSEAIIVLSRLVLQYCRMGFCIKAHSLLSRADGYIANHEVSCLARLSYELARVGFLLETGDNQKAATVLSTARMIYEKHQATEDLDACSVLTKISWERLVADAAFMSSRLSFAQGSIKDALYFAKLSVRLNCRIWAKVEKLAQKKQEKAVVGDSSELEIVVEGMAKLEVSQTSSTYSQGAPFWPHIGSHHSSLLHLANLSAHHGLFQDAIYYGEQALKINKSLNANVRLIASQAHLGSHWILGGHISEGQQLLASAKALSDKLGSSIELVSLRLSLAALHRVEGDYRNEYRTLREAEKLLGGLFESQADSADIPDLEEKMDKLRVRPKSRSTRQPATTATRRTRSATTSARSTPKPPQSVEATNASNTLLQMKSEILLQQAASLRAQREFEAASTLLSDARKFAVTRNSRISVHLGESEHLLADAIRNFANHAVYCVLPESTISLPSLEPKAASESSSKSATRKTRAPTRGTRTKAQAATEDFSVMLSKAGDCLNGIFDTATQLGSTLDSHSASRLMSRISMLSHVTASPNHILWPHSPANMNEVGRIGAFARERAAIRIDKRLADYCDPLLWPRSELESEGVSPDFTKEYVDILPDNWNVLSLSLSADRAEFVVSRLHRGCSPFLLRLPLRRGNSEDEEEQFTFEDGRDEMKELIRLANESAHAAKLQVDRQMKKEWWKNREALDRRMENLLQNIENVWFGGFRGIFSPIPLCEKSLARFASAFENILENHLPSRRKGSRAQGPKLTLHPNVLELFVGVKGLDDQEDPEDTLMDLLYFVVDILQFQGERNAYDEVDFDMMVVETLDAVRAYHEAAKDQATQRPNNTVLVLDKSLHLFPWESLPCLQGLPVCRVPSLECLRDRVLHLRSGKQSALSIDRRNGTYILNPTGDLKTTQETFEKDLSSLKGWTGMVNRQPTEDEFKDSLQSKSLFLYFGHGSGAQYIRGRTVKRLDRCAVAFLMGCSSGTLTEAGEYEPYGTPMNYLQAGSPALVATLWDVTDKDIDRFAKATFEHWGLIGNGHRGNEGIGEAGVALDAAVSQSRGACVLKYLNGAAPVVYGVPGVFLH</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-22" modified="2026-01-28" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AQA2</accession>
    <accession>C8V0W0</accession>
    <name>MMM1_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Maintenance of mitochondrial morphology protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">mmm1</name>
        <name type="ORF">AN9528</name>
    </gene>
    <organism>
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. The mdm12-mmm1 subcomplex functions in the major beta-barrel assembly pathway that is responsible for biogenesis of all outer membrane beta-barrel proteins, and acts in a late step after the SAM complex. The mdm10-mdm12-mmm1 subcomplex further acts in the TOM40-specific pathway after the action of the mdm12-mmm1 complex. Essential for establishing and maintaining the structure of mitochondria and maintenance of mtDNA nucleoids.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer. Component of the ER-mitochondria encounter structure (ERMES) or MDM complex, composed of mmm1, mdm10, mdm12 and mdm34. A mmm1 homodimer associates with one molecule of mdm12 on each side in a pairwise head-to-tail manner, and the SMP-LTD domains of mmm1 and mdm12 generate a continuous hydrophobic tunnel for phospholipid trafficking.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <text evidence="1">The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria-endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids.</text>
    </comment>
    <comment type="domain">
        <text evidence="1">The SMP-LTD domain is a barrel-like domain that can bind various types of glycerophospholipids in its interior and mediate their transfer between two adjacent bilayers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MMM1 family.</text>
    </comment>
    <comment type="sequence caution" evidence="3">
        <conflict type="erroneous gene model prediction">
            <sequence resource="EMBL-CDS" id="EAA66734" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EMBL" id="AACD01000234">
        <property type="protein sequence ID" value="EAA66734.1"/>
        <property type="status" value="ALT_SEQ"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF71019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AQA2"/>
    <dbReference type="SMR" id="Q5AQA2"/>
    <dbReference type="FunCoup" id="Q5AQA2">
        <property type="interactions" value="70"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5AQA2"/>
    <dbReference type="EnsemblFungi" id="CBF71019">
        <property type="protein sequence ID" value="CBF71019"/>
        <property type="gene ID" value="ANIA_09528"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AN9528"/>
    <dbReference type="eggNOG" id="ENOG502QUUW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032730_1_0_1"/>
    <dbReference type="InParanoid" id="Q5AQA2"/>
    <dbReference type="OMA" id="WSFTQGL"/>
    <dbReference type="OrthoDB" id="5376138at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032865">
        <property type="term" value="C:ERMES complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015917">
        <property type="term" value="P:aminophospholipid transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120009">
        <property type="term" value="P:intermembrane lipid transfer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990456">
        <property type="term" value="P:mitochondrion-endoplasmic reticulum membrane tethering"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045040">
        <property type="term" value="P:protein insertion into mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd21671">
        <property type="entry name" value="SMP_Mmm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03103">
        <property type="entry name" value="Mmm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027537">
        <property type="entry name" value="Mmm1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019411">
        <property type="entry name" value="MMM1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031468">
        <property type="entry name" value="SMP_LBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13466:SF0">
        <property type="entry name" value="SMP-LTD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13466">
        <property type="entry name" value="TEX2 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10296">
        <property type="entry name" value="MMM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51847">
        <property type="entry name" value="SMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword id="KW-0445">Lipid transport</keyword>
    <keyword id="KW-0446">Lipid-binding</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000384230" description="Maintenance of mitochondrial morphology protein 1">
        <location>
            <begin position="1"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="44"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="SMP-LTD" evidence="1">
        <location>
            <begin position="124"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="51"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="270"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="370"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="81"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="270"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="281"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="450"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="472" mass="50923" checksum="872CEFE9C0F1DA36" modified="2011-11-16" version="2">MAFQQGEAAPVSTQSSLSFTQGFLLGQLSVVLLIGAFIKFFIFGEAPPPPSRGLRASTHRRSNSIFSQDAPPPRSLREKPSTSNVLRPVPSSATNTRSILRKTYYSAIPPNPSSKHRIHHSSHQPESLDWFNVLIAQTIAQYRQTAYLLKDSPTSSILHSLTAALNNPEKKPSFIDKITVTDISLGEEFPIFSNCRIIAVDDPMSDGGRLQALLDVDMSDDNLSIAVETSLVLNYPKPCSAILPVALSISVVRFSGTLCISLVPASTPPLHTPSPMPSPPTAGAQPAAGAQPTDGGDIPPKSSSKSNIAFSFLPDYRLDLSVRSLIGSRSRLQDVPKVAQLVEARVHAWFEERVVEPRVQVVGLPDLWPRMGRTGVRTGDESETGSNTASRPAMSVDMSSPGHLQGDGGNHEEELRFRGLGPRPPLPFDAVSRTSSYQVETGAPRSPSLTRERSLGDDFHMPGSMPEAPGAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AQJ8</accession>
    <accession>C8VLA6</accession>
    <name>Q5AQJ8_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_09432</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF84587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_868814.1">
        <property type="nucleotide sequence ID" value="XM_863721.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AQJ8"/>
    <dbReference type="GeneID" id="3684025"/>
    <dbReference type="KEGG" id="ani:ANIA_09432"/>
    <dbReference type="HOGENOM" id="CLU_1111387_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AQJ8"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF84587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="293" mass="32851" checksum="9B8B4B7B260D0D6A" modified="2005-04-26" version="1">MPSIRDNDLRKSPEYCHYLEAVKDGELTLPDFKIDDNGVPDIHPYEVYCRVKGCLKRTVPSANRNILVKHLKDKNSHGMEFTLHNGPPTMKELMEAKGKSYLDYLACLKALFSQPRLLPRSASELPPSPRTTILRVSRIPTRVKLEMIRTMARALQVIRREGSKAAKSAGEKGTIPCKTCRNAKGKVSAPCGSKPYCEFWRFFSSIDEAKGASMQPHMDNAKETSNEESVLNKENEHENEEEKAAEPEEVQGDGRHVSEHLAITPFAQLNSGEDNSIATNLDLRDFGLNLESI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AQT4</accession>
    <accession>C8VR49</accession>
    <name>Q5AQT4_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ANIA_09346</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF87446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_682615.1">
        <property type="nucleotide sequence ID" value="XM_677523.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AQT4"/>
    <dbReference type="GeneID" id="2867868"/>
    <dbReference type="KEGG" id="ani:ANIA_09346"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN9346"/>
    <dbReference type="eggNOG" id="ENOG502R97D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037227_1_0_1"/>
    <dbReference type="InParanoid" id="Q5AQT4"/>
    <dbReference type="OMA" id="RQFIWSD"/>
    <dbReference type="OrthoDB" id="2130169at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540">
        <property type="entry name" value="TRANSCRIPTION FACTOR (ACR-2), PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF87446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="475" mass="53498" checksum="056E4E3C2B6EC6CC" modified="2005-04-26" version="1">MVEDFRFISIQVNDHAKDKASQRQARSHAVKRALERKRKQQQLSRANFIIKTFKDRDLDKSGRTETPCTVTSSSLAPVVSHLSGALDPFQTLAVNSSRLQALLGDYRARQAPEPVFSVAQELAFQSFRSVFRTGFDDPALINAVMLALAYAVTGGNLDRECLRYQGQAITYIRERMASEDDAASEATIGAILLIAGVAARLGLTYQVELHMGAVQQLLKICQRKSVNLTAGIKRAIFWSAYLLTISSLRRQDLNSTLLAGSRRIVDHTTFAVLLWTRNAFASSDYRLPPGFQSRSHMFGKKFTAVLEDLHALQCMRNVPQQQKADAMVMLHINNHTASVQSRLIALSDLSRLQDCCRLAACLCSVTLCCKVWCELVIPSHISSQLLIQIREARYADPVIWNGDTNSDLLVWLLYIGGSFAPKGVVRSGYLELLAPYSYFSWPELHDHMRQFFWSDHAFLAPVRALWREMSQIHFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="101" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ARS0</accession>
    <accession>C8VKZ1</accession>
    <name>Q5ARS0_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS nicotinic acid transporter Tna1, putative (AFU_orthologue AFUA_3G03820)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ANIA_09010</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF84467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_682279.1">
        <property type="nucleotide sequence ID" value="XM_677187.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ARS0"/>
    <dbReference type="FunCoup" id="Q5ARS0">
        <property type="interactions" value="159"/>
    </dbReference>
    <dbReference type="GeneID" id="2868283"/>
    <dbReference type="KEGG" id="ani:ANIA_09010"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN9010"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_0_1_1"/>
    <dbReference type="InParanoid" id="Q5ARS0"/>
    <dbReference type="OMA" id="GKLGWSW"/>
    <dbReference type="OrthoDB" id="2962993at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
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    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000068">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF18">
        <property type="entry name" value="NICOTINIC ACID TRANSPORTER TNA1, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G03820)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="208"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="294"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="326"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="355"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="380"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="415"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="448"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="49"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBF84467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="503" mass="56168" checksum="AB51D1B131EFF957" modified="2005-04-26" version="1">MAIPDADLEYEKPSVIALEGNDHGGLTSLDQVFPPDMQKRVLRKMDLRLIPMLALLYLLAFLDRGNIGNAKIEGMLDDLHMSGSEYNWCLTVFFFTYVAFELPSNLLLKKLRPSRLLPLLMVAWGIVMTLMGIVQDYHGLLISRLFLGVAEAGLYPGIAYYITLWYPRHLAQYRQAMFFSAASVAGAFSGILAWAIAKMDGVGNYAGWRWIFILEGILTVLVGIIAPFAMYDFPETATFLTEEERKYVIHALRTQNSGQDTLSAGGDAVEEQAKFRPRYVLDALTDWQIYVGLFMYWGITCPLYGISFFLPSIIRDLGYTSSTAQLLTVPIYITAAAVAVAGAWLSDRYKKRSPFILFFMSLIAIGFVIVLASSDRGVPGVVYFGVFIAVVGIYPAFPGNVTWISVNLAGDYKRAAGMAIHIGLGNMAGAMASNFYREQDAPKYTLGHALELGFCVVGLLAVLILRFSYKRINKKREAMDLSQWDSYEMAKMGDRSPMFRYML</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ARS4</accession>
    <accession>C8VKZ5</accession>
    <name>Q5ARS4_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_09006</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF84475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_682275.1">
        <property type="nucleotide sequence ID" value="XM_677183.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ARS4"/>
    <dbReference type="GeneID" id="2868260"/>
    <dbReference type="KEGG" id="ani:ANIA_09006"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN9006"/>
    <dbReference type="HOGENOM" id="CLU_099165_0_0_1"/>
    <dbReference type="InParanoid" id="Q5ARS4"/>
    <dbReference type="OMA" id="HTSIQGP"/>
    <dbReference type="OrthoDB" id="4441576at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021054">
        <property type="entry name" value="Cell_wall_mannoprotein_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38123:SF3">
        <property type="entry name" value="ANTIGENIC CELL WALL GALACTOMANNOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38123">
        <property type="entry name" value="CELL WALL SERINE-THREONINE-RICH GALACTOMANNOPROTEIN MP1 (AFU_ORTHOLOGUE AFUA_4G03240)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12296">
        <property type="entry name" value="HsbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010208608" evidence="1">
        <location>
            <begin position="21"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF84475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="171" mass="18663" checksum="7E9D30CFCAF06B09" modified="2005-04-26" version="1">MKVFNAILILYTLLPSLAIAQSPIDAALAQFQQLNDRIDSAQRSINAYNGGVLLALPVANSLYSAHTAATTARQSLTALDPLSPEDSQRALDAYNEVHPRLLATLAAGRDKAQVFRDAGVGYVAQGMISNLYNEKNRFEAALRDKIYPGYFQNDLAEAVDHAFQGTLAQFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ASU8</accession>
    <accession>C8VAD7</accession>
    <name>Q5ASU8_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_08632</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CBF78292.1"/>
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        <property type="nucleotide sequence ID" value="XM_676809.1"/>
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        <property type="entry name" value="Formin_homology_domain"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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</entry>
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    <accession>Q5ASV6</accession>
    <accession>C8VAE5</accession>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
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            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
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            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
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            <begin position="146"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF78307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AT47</accession>
    <accession>C8VEQ0</accession>
    <name>Q5AT47_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nucleoside phosphorylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ANIA_08533</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF80744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_681802.1">
        <property type="nucleotide sequence ID" value="XM_676710.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AT47"/>
    <dbReference type="STRING" id="227321.Q5AT47"/>
    <dbReference type="GeneID" id="2868658"/>
    <dbReference type="KEGG" id="ani:ANIA_08533"/>
    <dbReference type="HOGENOM" id="CLU_000288_34_22_1"/>
    <dbReference type="InParanoid" id="Q5AT47"/>
    <dbReference type="OMA" id="WAREEKV"/>
    <dbReference type="OrthoDB" id="1577640at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF11">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF80744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="256" mass="28036" checksum="B0F973D40FBF65B7" modified="2005-04-26" version="1">MIIYTGYMQIGDHNVAIACLPAEITGKASAATVARDMIRSFPAMRFGLMVGVGGGAPYYGVRGNNGFLATKEEGNPDDSEDSEDGSEDIRDIRLGDVVISLHSKSSEAVVQYDFGKSLQEKEFLRSGGALNKPPSIVLSAIGVLKAQHQLEGHKICQTLAEMVSRYPALAKKFQYPGSQKDYLFKSDFVHKAGRRTCKTCRSSDSNLVKRPNRPDNSPRLHYGTIGSADQVINDAILRDKWAREEKVICFEMEAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AUN7</accession>
    <accession>C8V5L4</accession>
    <name>Q5AUN7_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">GARP complex component (Vps54), putative (AFU_orthologue AFUA_5G02510)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ANIA_07993</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS54 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF73667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_681262.1">
        <property type="nucleotide sequence ID" value="XM_676170.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AUN7"/>
    <dbReference type="FunCoup" id="Q5AUN7">
        <property type="interactions" value="430"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5AUN7"/>
    <dbReference type="GeneID" id="2869047"/>
    <dbReference type="KEGG" id="ani:ANIA_07993"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN7993"/>
    <dbReference type="eggNOG" id="KOG2115">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003094_1_0_1"/>
    <dbReference type="InParanoid" id="Q5AUN7"/>
    <dbReference type="OMA" id="QKQAVML"/>
    <dbReference type="OrthoDB" id="10259024at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000938">
        <property type="term" value="C:GARP complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.860">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039745">
        <property type="entry name" value="Vps54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012501">
        <property type="entry name" value="Vps54_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12965">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING 54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12965:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07928">
        <property type="entry name" value="Vps54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Vacuolar protein sorting-associated protein 54 C-terminal" evidence="8">
        <location>
            <begin position="788"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="143"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1028"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="14"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="153"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="175"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1046"/>
            <end position="1062"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBF73667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="1062" mass="117903" checksum="7A987E5F9A5A662D" modified="2005-04-26" version="1">MSASPRKSIDSLASGASTPSLSQYSFNQIESPRGSSQRYPLRRGSTASSIVSIGGVLDPSSRHGAIAESGQNAISTLLQPPIVRTGLVPHSSAASGGYKPPSTRDIPPVPLTNIPHIDRKAFEPYLTQVGSLYEVFQEAKENNEQDAQLARGGQTSPRSDGQDSLSPRNLERRLSGVSTSSRSTSPYAAGKRKSSNRGRTPAVTPLSTIPSVYFEDDFRLENPRTFDVVSERSEVVTPPKAPSKDNKMDIVEPAPTGRKALATNAILQEKLSWYMDTVEIHLISSISTASKSFFTALGSLRELHAEAADSVRRIQVLRKDLQKIDREMALGGLKIVNLRRRRENVRMLADAVAQLRDVVESVTRCEELAEDGNIEEAADGLEKVEKLMAGDYTPDQAEGEQRRTLDLRRLKALEGASNELDRLRYQIGTGYENRFLNELLGDLRRHVDSAPLTATVQRWGYSFSRQRGGHRSSINEPPAYMCVGEDFRYQLRLHLTGLARVHHTTTAATAFKTAILREMKSLIRRHMPSSNDDDNESMVSVSTHRSHQLSSQEKSSILARNLRAMDAEDAYNMLAQVYTGVSESLRRLSVQVKVLLDIASGLGSLQSPKSPVGNAGPRDIPHAAQDEILQVLDMSSLLGQAVDIAQSQATKVLKVRSEQTANLCKEDFVKYFILNRLFADECEAISGRGGTAFKTVVGNQIRDFINRFGNEQRHRIVQVMDADRWDAKDFGESESEVLDRILSASTKDVDTWIDVSKIWVAKEQKPPHSPAVNGSKEKEKTRSAVIDEQKYILSDSALAMMRSIEEYQFLMANIPNMIPDISSGLLESLKLFNSRSSQLILGAGATRSAGLKNITTKHLALSSQALSFIIALVPYIREFVRRHSPPASLMADFDKVKRLYQEHQSGIHEKLVDIMGSRSSIHVNAMRQIDWDSSSRPAGVSPYMETLTKETGTLHRVLSKHLPEMTVIMIMDPVFKSYRDQWTRAFDEAQIKTEVGKQRLHRDAEYFQAKLSKIDGFGDLGERLLELVDKKTTEAPAQESPERSSRQGSPQSQNEAKGQGQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="111" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AVP4</accession>
    <accession>C8VBY5</accession>
    <name>Q5AVP4_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase (Eurofung)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_07636</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF79791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_680905.1">
        <property type="nucleotide sequence ID" value="XM_675813.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AVP4"/>
    <dbReference type="GeneID" id="2869441"/>
    <dbReference type="KEGG" id="ani:ANIA_07636"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN7636"/>
    <dbReference type="eggNOG" id="KOG1198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_3_4_1"/>
    <dbReference type="InParanoid" id="Q5AVP4"/>
    <dbReference type="OMA" id="YTINYRT"/>
    <dbReference type="OrthoDB" id="3509362at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08276">
        <property type="entry name" value="MDR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052711">
        <property type="entry name" value="Zinc_ADH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033:SF1">
        <property type="entry name" value="OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="13"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF79791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="353" mass="37919" checksum="6B8142C5419693C5" modified="2005-04-26" version="1">MSSIQQWTTSLQGLDSLQSVEAPKPTAGPGEVLVRISAVSLNYRDYEVCCGLYGHHKSVSQDKASLVPCSDMCGEIVEVGEGVTGWQKGDRVLSTFLPDHQTGQVVEKMMASGLGLPQPGVLAEYRAFPAHGLVRAPSYLSDEEAATLPIAAVTAWMSINGMRPKGQNGGEGEYILLQGTGGVSVSGLQIAKASGAKTIITSSSDDKLKQAKELGADYTINYRKTPNWEEEVLKLTDNHGADIIIEVGGAGTLKKSFNCIAWGGLIDCVGYLSGKVDAPEDRTNVNLLALSRNVTLKGIINGPKDRFEEMIAFYEKHSIKPVVNKVFSFKDAPEAFKYLANGQHFGKIVIKIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AVX5</accession>
    <accession>C8VBP1</accession>
    <name>Q5AVX5_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_07555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF79622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_680824.1">
        <property type="nucleotide sequence ID" value="XM_675732.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AVX5"/>
    <dbReference type="GeneID" id="2869559"/>
    <dbReference type="KEGG" id="ani:ANIA_07555"/>
    <dbReference type="eggNOG" id="ENOG502SBM6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040837_2_0_1"/>
    <dbReference type="InParanoid" id="Q5AVX5"/>
    <dbReference type="OMA" id="INWAKYQ"/>
    <dbReference type="OrthoDB" id="20473at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037830">
        <property type="entry name" value="ZZZ3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22705">
        <property type="entry name" value="ZINC FINGER, ZZ DOMAIN CONTAINING 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22705:SF0">
        <property type="entry name" value="ZZ-TYPE ZINC FINGER-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF79622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="234" mass="25247" checksum="A3F28A043CA74902" modified="2005-04-26" version="1">MDQRHSISPVNTTAVPESAINRPSSDSTGPTASQQDHADQVNETQRPGTPPRPPYSPVTPVFAHLAPVQDPSTNGMTQPIVPPTTSPSPTSQVPPTPPNPSSLPPRAPPTFAPEPPPPVPISESDNPDAIALRSAISILQLQKQQSLRDIQTLERMKEAAAKDPERFARELIDGKLARKEQGGFIDFNHEEEDRDGDTETAEGGSRISSELGTLPAAQNIVRMPAINWAKYQIN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-02-10" modified="2025-04-09" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AVZ0</accession>
    <accession>C8VBM6</accession>
    <name>EIF3D_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Eukaryotic translation initiation factor 3 subunit D</fullName>
            <shortName evidence="2">eIF3d</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ORF">AN7540</name>
    </gene>
    <organism>
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. In the eIF-3 complex, eif3d specifically recognizes and binds the 7-methylguanosine cap of a subset of mRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="2">The RNA gate region regulates mRNA cap recognition to prevent promiscuous mRNA-binding before assembly of eif3d into the full eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eIF-3 subunit D family.</text>
    </comment>
    <dbReference type="EMBL" id="AACD01000129">
        <property type="protein sequence ID" value="EAA62120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF79596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_680809.1">
        <property type="nucleotide sequence ID" value="XM_675717.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AVZ0"/>
    <dbReference type="SMR" id="Q5AVZ0"/>
    <dbReference type="STRING" id="227321.Q5AVZ0"/>
    <dbReference type="EnsemblFungi" id="CBF79596">
        <property type="protein sequence ID" value="CBF79596"/>
        <property type="gene ID" value="ANIA_07540"/>
    </dbReference>
    <dbReference type="KEGG" id="ani:ANIA_07540"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN7540"/>
    <dbReference type="eggNOG" id="KOG2479">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024521_2_0_1"/>
    <dbReference type="InParanoid" id="Q5AVZ0"/>
    <dbReference type="OMA" id="FMDKRDN"/>
    <dbReference type="OrthoDB" id="16538at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3e"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071541">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3m"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098808">
        <property type="term" value="F:mRNA cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002191">
        <property type="term" value="P:cap-dependent translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="P:translational initiation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03003">
        <property type="entry name" value="eIF3d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007783">
        <property type="entry name" value="eIF3d"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12399">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12399:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05091">
        <property type="entry name" value="eIF-3_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016281">
        <property type="entry name" value="EIF-3_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0396">Initiation factor</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <feature type="chain" id="PRO_0000364175" description="Eukaryotic translation initiation factor 3 subunit D">
        <location>
            <begin position="1"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="107"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="RNA gate" evidence="1">
        <location>
            <begin position="301"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="566"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="108"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="566"/>
            <end position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="K7IM66"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="586" mass="64872" checksum="1B5949AD48342AFF" modified="2005-04-26" version="1">MAPISIADIVAALPAEDTWGPVTSADNMLDGVPYAPFSKGDKLGRMADWTADSKDRDRGGRQAYNRNYRDQQVYGAGSSSLFAVQVAEDESTFSVVDNTRTSAKRTFGRGGGTVFRGRAQRGGAGQRGGRAGFQRVGAGRGQGGDRYYDNRGARGNRGRRFGWKDYDKPQRTREPSVNIRPDWSMLEEVDFNRLSKLNLQAPEGEDVDTYGFLYYYDRSYDKAPVKNAERRLQALDRAAYNVTTSQDPVIQELAEKNQATIFATSDILSMLMCAPRSVYSWDIVIVHQGNKIYFDKREGASLDLVTVNENAADAPLEVAESSGKQESINTPSALALEATFINHNFALQTVVEANNAKVDFNHPNPFYNAEEETEPLASKGYKYRRFDLSLESDEEPLNMIVRTEVDALVKNPVNGEDQQLVVKALNEFDSKAQGSGGSLDWRSKLYSQRGAVVATEMKNNSCKLARWTTQAILAKADGMKLGFVSRANPRSAAAHVVLGVAGYKPREFAAQMNLNLGNGWGIVRTIVDRIRALDADEEEDKVTKYILVKDPNRPVLRLYSVPANAFEEDDEAAEEEQEAKGEVEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="101" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AW12</accession>
    <accession>C8VBK4</accession>
    <name>Q5AW12_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">FAD-binding FR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">ANIA_07518</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF79549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_680787.1">
        <property type="nucleotide sequence ID" value="XM_675695.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AW12"/>
    <dbReference type="STRING" id="227321.Q5AW12"/>
    <dbReference type="GeneID" id="2869589"/>
    <dbReference type="KEGG" id="ani:ANIA_07518"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN7518"/>
    <dbReference type="eggNOG" id="KOG0039">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010365_1_1_1"/>
    <dbReference type="InParanoid" id="Q5AW12"/>
    <dbReference type="OMA" id="INTYFAQ"/>
    <dbReference type="OrthoDB" id="167398at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000293">
        <property type="term" value="F:ferric-chelate reductase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
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        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF9">
        <property type="entry name" value="FERRIC REDUCTASE TRANSMEMBRANE COMPONENT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="227"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Ferric oxidoreductase" evidence="10">
        <location>
            <begin position="143"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="Ferric reductase NAD binding" evidence="11">
        <location>
            <begin position="344"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
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            <begin position="440"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="451"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CBF79549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="567" mass="63436" checksum="221EDDE48922BC6B" modified="2005-04-26" version="1">MSLHSLSSAEYYFGHINPQKREGKGKTAESLPGPWTRPFVHFQLSRYRIQQYPTRQTLTRTPLNTLHYVKTYIALPASFGPFLTNHQQLFWYHAIPRRLDRLIVLGFWALCIILACVDYQSFDGNIGMTSLSQQNWQYSSDRTGILSYACLPFLWLFGGRNNIFLWATDFNTQSFNIFHRHVAWACTLLAIVHSINYSVFLLTTATILMSFMLVQSMTILRHKGYETFLILHIVFAIVVVYALFRHTSFDGTKWNGYLWPMIAIWAFDRVVRLIRIAYCNLNPVNLKGWENHPFTLGAYVPPSLSLATGSESIQVHEKRQQDSKPIFYAGRDGCETNAANLDFMVVGGTGIAAAVPYIIDHISRSGGAAKTRTTRLRLIWSAKTNEMFERVFCDELAGTLGHEDIMTSFYCTSSKTSFSSSPSSSAAVLELSLATKEKEAGVSVLPTGEKSPSSSNLSGSSNDNAILDARAPSRDPPLPEAADGEASANTSKLATARNPVEFLSGRPNVRAIVTSEAQKAKANSSRLAVLTCGPAQMADECRQTVYEVMRRKNGLRDIEYFEEAFGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AW13</accession>
    <accession>C8VBK3</accession>
    <name>Q5AW13_EMENI</name>
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        <submittedName>
            <fullName evidence="2">HypA-like protein, putative (AFU_orthologue AFUA_5G03330)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_07517</name>
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    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF79548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_680786.1">
        <property type="nucleotide sequence ID" value="XM_675694.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AW13"/>
    <dbReference type="GeneID" id="2869390"/>
    <dbReference type="KEGG" id="ani:ANIA_07517"/>
    <dbReference type="eggNOG" id="ENOG502S69W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019145_2_1_1"/>
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    <dbReference type="OrthoDB" id="10004862at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025337">
        <property type="entry name" value="Questin_oxidase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35870">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G03330)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35870:SF1">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G03330)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14027">
        <property type="entry name" value="Questin_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF79548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="444" mass="50309" checksum="5756BC3DD2DE004A" modified="2005-04-26" version="1">MATARKVLLSPRSDTGVWSTGITESAAKTASAALQEDLEKHHVYFNDMGFHDHIAHQILTLYALGASPDEIQAAYDRNKTYQRKALPMHEDVVNGLHQKDKFKDALGKEKNYPDFLEFFQREIDKKGVEAVLSEYLFKQDENAESMMARLFGGLLHPIIHLGFGIEFNQPAIIAEALAQTAIHEDWTGPRFLFPAEQVAGGIGKPGRKTMLQLLEEAQENTKLTNSVRFEDGNKLRDGVLKRAGKDMIELAAQYTVSEEQMAEKYAEIVDVSVYFTAASQRPTKSVKFDFFYIHTVNSSIFFAKILVLPFLHTATKLRLLEMKGRMDLFMYVSRNAPQLYLGEVTKYPINQTWESIIKQSVQHTHDDGHLVKLIRALKHGEAVCRTYEGQGREKGLKITGDSWLRIGNMVVVIDSVHGRGEEKMWVRSTGFDEAWDAVEDRARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AWB0</accession>
    <accession>C8VCB9</accession>
    <name>Q5AWB0_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ANIA_07420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF78411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_680689.1">
        <property type="nucleotide sequence ID" value="XM_675597.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AWB0"/>
    <dbReference type="GeneID" id="2869851"/>
    <dbReference type="KEGG" id="ani:ANIA_07420"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN7420"/>
    <dbReference type="HOGENOM" id="CLU_2145830_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AWB0"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF78411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="112" mass="12108" checksum="DE5CF98156417837" modified="2005-04-26" version="1">MLLWGLSRASSLLARWVNHNSYLEKITAGPAILDPPWGKAGRQQVSLHGLIKDCWRLGGHSSGGAGVAPQLALPAMAVGKSGCGAEIWSKDAKLRTYKLCYYAAMSLIREEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AWF2</accession>
    <accession>C8VCG8</accession>
    <name>Q5AWF2_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_07378</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF78503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_680647.1">
        <property type="nucleotide sequence ID" value="XM_675555.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AWF2"/>
    <dbReference type="GeneID" id="2870034"/>
    <dbReference type="KEGG" id="ani:ANIA_07378"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN7378"/>
    <dbReference type="eggNOG" id="ENOG502SBH1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_137500_1_2_1"/>
    <dbReference type="InParanoid" id="Q5AWF2"/>
    <dbReference type="OMA" id="NEYENFT"/>
    <dbReference type="OrthoDB" id="2841294at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045469">
        <property type="entry name" value="Nis1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19271">
        <property type="entry name" value="Nis1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013062385" evidence="1">
        <location>
            <begin position="16"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF78503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="137" mass="14152" checksum="E8251E21749331AC" modified="2005-04-26" version="1">MKIFALLTLAATALAQNAGLNLPGGTNLTAGSDIIVQVTRVNSLTGSTELAVAIGLQTCPKGNCIPADEMLGTAQLYHGDFNPQFHEDYPSPYENFTVTIPASTPKGKAVVAVAHAALVGASNEPLFEVLNSTVTIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="101" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AX81</accession>
    <accession>C8VDD5</accession>
    <name>Q5AX81_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_07099</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF79085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_664703.1">
        <property type="nucleotide sequence ID" value="XM_659611.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AX81"/>
    <dbReference type="STRING" id="227321.Q5AX81"/>
    <dbReference type="GeneID" id="2869815"/>
    <dbReference type="KEGG" id="ani:ANIA_07099"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN7099"/>
    <dbReference type="eggNOG" id="ENOG502SHSC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_324159_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AX81"/>
    <dbReference type="OMA" id="WPYINEV"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42345:SF2">
        <property type="entry name" value="HELICASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42345">
        <property type="entry name" value="TPR_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="491"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF79085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="891" mass="98872" checksum="130D7298D1528E99" modified="2005-04-26" version="1">MNSIKARFKRMSIGRTGKDPNTSGKTDAAASAERTPDEGRKNAPANSNAANVDSGLAAARMFLKDEREGSLVFTVQVATAYRPCIAVDVHRFGEKQGDGPYGKPAGLTKMSRAEHGFVEAEHPSFELYRIQRKYLRRHSESPNELDEEDCILFDPEASPLYDHAHANGTVTVEGFGLDLWNAELAHGRMPQQAHPNILLEVPELTFNPATLLCRIEEIRSRTVPADDPQEEIAALVETVGKVAWESITGSWEMQGMGHSERVLEFLFAFHHEQEDLSGRSVIADTMTRFQDGSYEGAWADWMRMVMARELALRLASGAGMGMQWAGGTKGIYVRFTRAILASLIISERWFANTRIHVGGHVALAREVQDAKSAGVSEQDRQEAWELVRLAEEATEAKQFQRAAVLFYEALAVNPANYDSVQARGEWLLRFQNYRDAARDAVVLQRLDPNRPAGYVLLGRACLGYKNYLRAREAFREAVALAHTFDEKLPILQDLDKAQDALSAELKAIEQAASEKEKAALMRARRIADLDPMGRTIAPRPAKHEQQLEGLFLFAERMQWPYLEAVRRCAKKACEDWLALHEPVYPVQMDWLFAVMLPGKHFAHVLMAMLILSTPAFQSVGMAPDSECGLALPECSYWRSRSVLGRVLGCLPGVTSLNGWVGPCPTATLHTQVDEEAPAAHCLITTVAFNPASAMLPPPSAESTRDIVIAGNPDLAPLWRVTNQPEILNLPPPQRDTAAWEIRSLDLRRAYRSHQFERGGTWLWSASLAFRQPGTGKEVNFALEHTPVFITLPPCSLSGQARGHKIHRRQFDYYRFRNVSMDEIAEVTPESVEEEIIVINASAPGAEVVARAWCAHVARAAVVRRAGGPCFCCTVKGAGRLGLRVGVVIWVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="116" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AXB7</accession>
    <accession>C8VB40</accession>
    <name>Q5AXB7_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ANIA_07063</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF79162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_664667.1">
        <property type="nucleotide sequence ID" value="XM_659575.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AXB7"/>
    <dbReference type="GeneID" id="2869940"/>
    <dbReference type="KEGG" id="ani:ANIA_07063"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN7063"/>
    <dbReference type="eggNOG" id="KOG1399">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006937_6_3_1"/>
    <dbReference type="InParanoid" id="Q5AXB7"/>
    <dbReference type="OMA" id="MPNYFMV"/>
    <dbReference type="OrthoDB" id="74360at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051209">
        <property type="entry name" value="FAD-bind_Monooxygenase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000960">
        <property type="entry name" value="Flavin_mOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877:SF11">
        <property type="entry name" value="MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G13790)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000332">
        <property type="entry name" value="FMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBF79162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="551" mass="62243" checksum="3B820C86DCE07CBE" modified="2005-04-26" version="1">MGSLGTQEQYFVKDQYIHQRRRIRIIVIGAGISGIAFAYKVRELENVEYQIYEKNEDVGGTWFESRYPGCSCDIPAHSYTYPWAGNPEWSRVYAGAEEIWRFYRDRAEEYGVYRTTKFRHQVVGATWNEAQGRWTVKIEDLASGQVFEDSAEVVINCAGVLNKWKWPDIPGLHSFNGTLVHTARYPQDLDLTDKRVAVIGAGSSAIQVVPTIQPVVKSLISFNRSPTWIAPQFAGHLASAGRATAYTEEEKEKFRNDPDYLRQYRKQIDQALNSRFPNFYKGSQEQKASRQIVETAMRERLSKMDPDLREKLIPDFDVGCRRVTPGDGYLEALQEPNVEVVRTRIQEVTPEGVVTADGKLYAADVIIAATGYDTSYVPPFPLIGRNGVDLGKRWAQTGAEAYLTCAVPDMPNYFMSVVVGPNTPISNGSLMPAIENQLQFALTFARKIQSEGVKAVVVSQQATTEFNEHKDAVMKLLTFSGSCNSWYKGGTSDGRIVGPWCGSLNHFLESIAEPRLQDFEFTYETQNRFAYLGRGLSLRDVQKKDLAWYIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AXX3</accession>
    <accession>C8V2N4</accession>
    <name>Q5AXX3_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Alpha-1,2-mannosyltransferase, putative (AFU_orthologue AFUA_5G13090)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ANIA_06857</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MNN1/MNT family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF71605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_664461.1">
        <property type="nucleotide sequence ID" value="XM_659369.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AXX3"/>
    <dbReference type="FunCoup" id="Q5AXX3">
        <property type="interactions" value="77"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5AXX3"/>
    <dbReference type="CAZy" id="GT71">
        <property type="family name" value="Glycosyltransferase Family 71"/>
    </dbReference>
    <dbReference type="GeneID" id="2870557"/>
    <dbReference type="KEGG" id="ani:ANIA_06857"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN6857"/>
    <dbReference type="eggNOG" id="ENOG502QQ16">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013298_0_1_1"/>
    <dbReference type="InParanoid" id="Q5AXX3"/>
    <dbReference type="OMA" id="VEIEHYQ"/>
    <dbReference type="OrthoDB" id="4484309at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046354">
        <property type="term" value="P:mannan biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022751">
        <property type="entry name" value="Alpha_mannosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31646">
        <property type="entry name" value="ALPHA-1,2-MANNOSYLTRANSFERASE MNN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31646:SF1">
        <property type="entry name" value="ALPHA-1,2-MANNOSYLTRANSFERASE MNN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11051">
        <property type="entry name" value="Mannosyl_trans3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBF71605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="490" mass="55105" checksum="618FC169846DA7A0" modified="2005-04-26" version="1">MPKLRRSRLRTVLSIVAALFLVIGVFKINWTPAPASVVVPNTAFEVPLTERQNVFWKGFKPILEANSPNCPPPAHEQNADSIHFNATTTEVRPDLTFMDESSVSAMQDAHARFLHDIEETKRLKPVHAPGTRGIVSTAGGQYFPVFLATLRMLRRTGSKLPVEVYMKDADEYEENICEDVLPKLNARCLILSDVVGKDPIEHFQLKVFAVLLSSFEEVVWMDSDCFPLHEPDLLFDSDMFKSMGMITWPDFWQSSVSPVYYRISNQPEIPMNARQTTEAGVFLISKKSHLRTLLLSAYYNYYGPSHYFRLLSQGGPGEGDKETFLQAASAVQEPFYAVSERVQAVGHPAPNGLSGSAMAQSDPIEDQALVSQGLLRVLDPSVAQAPRVFFIHANYPKFNPGGNVWGTEFETAPTVRPDGSDGRAWIVPEDVIQRFGYDAEKAYWEELKFISCAPDIEFQTWTSKGKICHKVGQYWDNVFAEPHDDDFQWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="114" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AYL0</accession>
    <accession>C8V158</accession>
    <name>Q5AYL0_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Endo-1,3(4)-beta-glucanase, putative (AFU_orthologue AFUA_6G14540)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ANIA_06620</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF71114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_664224.1">
        <property type="nucleotide sequence ID" value="XM_659132.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AYL0"/>
    <dbReference type="STRING" id="227321.Q5AYL0"/>
    <dbReference type="CAZy" id="GH16">
        <property type="family name" value="Glycoside Hydrolase Family 16"/>
    </dbReference>
    <dbReference type="GeneID" id="2870592"/>
    <dbReference type="KEGG" id="ani:ANIA_06620"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN6620"/>
    <dbReference type="eggNOG" id="ENOG502SKUZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019533_3_0_1"/>
    <dbReference type="InParanoid" id="Q5AYL0"/>
    <dbReference type="OMA" id="CNEYNGI"/>
    <dbReference type="OrthoDB" id="192832at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02182">
        <property type="entry name" value="GH16_Strep_laminarinase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF60">
        <property type="entry name" value="GRAM-NEGATIVE BACTERIA-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH16" evidence="5">
        <location>
            <begin position="91"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBF71114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="388" mass="41994" checksum="FCCFFBA84914EC10" modified="2005-04-26" version="1">MARPSLCCLENTWGSQYMILAIHSFMMRRLLTIVPLLLRANAVPLANPNVQGVSDFPDILHDILPGLLDPGSGPGSDSHSEIVPPILGYTLTWHDEFSSSSQSSSDSDSGHLPSSSVWLFDTGTSYPGGAPAWGNNELQSYTTSPRNIRITPQNTLQIIPRFSGNNGTGEEGQWTSARIETRTTSFAAASGGKLYIESRLRTGCAPSSQQKGIWPAFWALGESFRGNPTNWPMASEWDIMEVINGEPTVYNTLHCGVDSNEGGPCNEYNGLGNSGVSWSGCDWHVVGLEVDRSGASLLGAGSGEGEGWQEETLTWFLDGEQVHRVSGADVGHETVWRTIAHKGHFLLLNVAVGGNWPGYPDENTVDGEEVAMEVDYVRVWNADGVDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="109" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AZ48</accession>
    <accession>C8V0F5</accession>
    <name>Q5AZ48_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fatty acyl-CoA reductase</fullName>
            <ecNumber evidence="1">1.2.1.84</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_06432</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a long-chain fatty acyl-CoA + 2 NADPH + 2 H(+) = a long-chain primary fatty alcohol + 2 NADP(+) + CoA</text>
            <dbReference type="Rhea" id="RHEA:52716"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:77396"/>
            <dbReference type="ChEBI" id="CHEBI:83139"/>
            <dbReference type="EC" id="1.2.1.84"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the fatty acyl-CoA reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.84" evidence="1"/>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF69485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_664036.1">
        <property type="nucleotide sequence ID" value="XM_658944.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AZ48"/>
    <dbReference type="GeneID" id="2871325"/>
    <dbReference type="KEGG" id="ani:ANIA_06432"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN6432"/>
    <dbReference type="eggNOG" id="KOG1221">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056023_1_0_1"/>
    <dbReference type="InParanoid" id="Q5AZ48"/>
    <dbReference type="OMA" id="CNEIPVD"/>
    <dbReference type="OrthoDB" id="429813at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102965">
        <property type="term" value="F:alcohol-forming long-chain fatty acyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080019">
        <property type="term" value="F:alcohol-forming very long-chain fatty acyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035336">
        <property type="term" value="P:long-chain fatty-acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026055">
        <property type="entry name" value="FAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11011:SF45">
        <property type="entry name" value="FATTY ACYL-COA REDUCTASE CG8306-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11011">
        <property type="entry name" value="MALE STERILITY PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioester reductase (TE)" evidence="2">
        <location>
            <begin position="21"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF69485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="404" mass="45262" checksum="DFE28B92E802FF16" modified="2005-04-26" version="1">MEGTMPANEYVRHFENAVVLLTGATGSLGGCLLYKLALRLPTKKIYALCRGSVGESVRKWESTMPQQIDEILDTGKVELITGDLSKPGLGLNPAIREEMREEVTAVINTAANISLVEELKDSVRDNCQTAIALFQEVSEFRHVRHFIQFSSLAVNAFLTGGLIEERLYSPPRTVDEEDDRLGLPGADSSKLQYDDRYPWPYVQAKHMLERLLLRQSSSISILIIRPAAIGPAIAEPFPLYGPDKAIPMHSLILCFSVSDLGRVANINRPFEEVPVDLVANCCLLHLASGTTGVVHCASELYVRQTAVELMATARQCITPLEIAELFRTPRASTAILWQNKYRLDNIDDVPVFEVDCSRSEWQKQVTGPLALRPVDHDPQAHLQRRIRRMYRALLGRNRSDNRYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="117" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AZI5</accession>
    <accession>C8V197</accession>
    <name>Q5AZI5_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BHLH transcription factor (Eurofung)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ANIA_06295</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF69761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="XP_663899.1">
        <property type="nucleotide sequence ID" value="XM_658807.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AZI5"/>
    <dbReference type="GeneID" id="2870976"/>
    <dbReference type="KEGG" id="ani:ANIA_06295"/>
    <dbReference type="eggNOG" id="ENOG502S8TF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034677_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AZI5"/>
    <dbReference type="OMA" id="DDNESNM"/>
    <dbReference type="OrthoDB" id="5778525at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="entry name" value="bHLHzip_Mlx_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052207">
        <property type="entry name" value="Max-like/E-box_TFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15741">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX ZIP TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15741:SF27">
        <property type="entry name" value="TRANSCRIPTION FACTOR AP-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="7">
        <location>
            <begin position="356"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="156"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="211"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="249"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="302"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="87"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="158"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="320"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="347"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBF69761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="436" mass="48412" checksum="3855AB471058C0A5" modified="2005-04-26" version="1">MSINPPNGTQGRHARNNSALPFGSSPVGPPLLDDTETNMLDNFLTTINSNPFANDYWFSDSQNDANNSLGLPGFDWSTELPPTFQGSTSSLPPFHPPSSSHRSVEKSLGIAPEHANSEVMAAASMLYQNGMNGPEISTAFGNQPLAFSNVDYSQLKGSGKERKQDGRMPEKGTGISRTHLPAGYHTTKMFFDVPEPISTEQQLITKAQPLHWGSDSSFMDRGYLAPPDQPDEEQRTKEMMEKLECLERQSSATNTRAPTPDRHVNQQPVPLFEPDAINHLNGLRKDYGDSIEDLSYPKKKQRLLIKEEDDENSDGNTSRQRCKRSKGPGRRPSTDGVRKSKPSQGSKPRENLTEEQKRSNHIHSEQKRRNLIKQGFDDLCTLVPGLRGGGFSKSAVLTQAADWLEDIIKGNQALRLQLAQLPDLSTMDNSMMRPRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="103" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B0M3</accession>
    <accession>C8UZU4</accession>
    <name>Q5B0M3_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribose 5-phosphate isomerase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_05907</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LacAB/RpiB family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF70594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_663511.1">
        <property type="nucleotide sequence ID" value="XM_658419.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B0M3"/>
    <dbReference type="STRING" id="227321.Q5B0M3"/>
    <dbReference type="GeneID" id="2870900"/>
    <dbReference type="KEGG" id="ani:ANIA_05907"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN5907"/>
    <dbReference type="eggNOG" id="ENOG502S47V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091396_1_0_1"/>
    <dbReference type="InParanoid" id="Q5B0M3"/>
    <dbReference type="OMA" id="VREWLTY"/>
    <dbReference type="OrthoDB" id="2106730at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1400.10:FF:000004">
        <property type="entry name" value="Ribose 5-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1400.10">
        <property type="entry name" value="Sugar-phosphate isomerase, RpiB/LacA/LacB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011860">
        <property type="entry name" value="Rib-5-P_Isoase_Actino"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003500">
        <property type="entry name" value="RpiB_LacA_LacB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036569">
        <property type="entry name" value="RpiB_LacA_LacB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051812">
        <property type="entry name" value="SPI_LacAB/RpiB"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004051">
        <property type="entry name" value="PRK05571.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02133">
        <property type="entry name" value="RPI_actino"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00689">
        <property type="entry name" value="rpiB_lacA_lacB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43732:SF1">
        <property type="entry name" value="RIBOSE 5-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43732">
        <property type="entry name" value="RIBOSE 5-PHOSPHATE ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02502">
        <property type="entry name" value="LacAB_rpiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005384">
        <property type="entry name" value="RpiB_LacA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89623">
        <property type="entry name" value="Ribose/Galactose isomerase RpiB/AlsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF70594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="157" mass="16896" checksum="89BD4B7630547007" modified="2005-04-26" version="1">MSQSLRIVFAADEAGQPYKETLKEVLSKNPNVSEVLDVGVNSTSDKTAYPHPAVEGAKLIRDGKADRGLFICGTGLGVAISANKVPGIRAVTAHDSFSVERAILSNDAQVLCFGQRVIGLELAKRLANEWVTYKFDPNSSSAPKVQAIKDYEAEFAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B0M5</accession>
    <accession>C8UZU6</accession>
    <name>Q5B0M5_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AttH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_05905</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF70597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_663509.1">
        <property type="nucleotide sequence ID" value="XM_658417.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B0M5"/>
    <dbReference type="STRING" id="227321.Q5B0M5"/>
    <dbReference type="GeneID" id="2870814"/>
    <dbReference type="KEGG" id="ani:ANIA_05905"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN5905"/>
    <dbReference type="eggNOG" id="ENOG502SPEU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046730_0_0_1"/>
    <dbReference type="InParanoid" id="Q5B0M5"/>
    <dbReference type="OMA" id="WIHNGSS"/>
    <dbReference type="OrthoDB" id="5295747at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.370.10">
        <property type="entry name" value="AttH-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023374">
        <property type="entry name" value="AttH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053112">
        <property type="entry name" value="Fungal_Dehydratase/Hydratase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40617:SF1">
        <property type="entry name" value="ATTH DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40617">
        <property type="entry name" value="TERPENE CYCLASE ASQC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17186">
        <property type="entry name" value="Lipocalin_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159245">
        <property type="entry name" value="AttH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010346607" description="AttH domain-containing protein" evidence="1">
        <location>
            <begin position="31"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF70597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="467" mass="52538" checksum="A1E6A7990BA2F982" modified="2005-04-26" version="1">MKFLPLESTLVVIESLVLVLALDFEPDTQGFNVHDYERLPLTLDLATSQSVVAAAGNSWWASSYIYASDNRPYFIVSHVGNPGPGYYRYSILDVSNPSYYRQYAYQGSEADPVSVHINGANITLPTYGFEAVDPADTLAAMRTWSTSDFEFDLTFELSSPVILNGGSGTFTWGPYLTYEWSLVGGITMGNFVVNDTRLTIDPVRSLTWYDRQVVFASGIDPSGSAASQNWTWFQLHYDRPEHRNNEKNSQFRPSKISVWIWDYDSNPRVQFATVLGFEQLAGQQQVLSVTEFTPSGRTWTSPGCGGTYPLDWTIALPDGTRLYIEAIRDDQEFCNASQPFQPTYEGFVSFKGVDGVGNNVVSINGNGFALGRPMALDRDSPRAFNAVTCSRFPPLLALHFIPSRGYQMRRSNQCRSPFRFQGVDHCLDVEEAQGPYENATAERNRETMIARFQRQRNKREKDHSLFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B1B3</accession>
    <accession>C8VFS6</accession>
    <name>Q5B1B3_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_05667</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
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            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF81440.1"/>
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        <property type="component" value="Chromosome V"/>
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    <proteinExistence type="predicted"/>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="CBF81440.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
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    <sequence length="691" mass="74453" checksum="589CE89F031EDBA1" modified="2005-04-26" version="1">MAKIDAAEGESASCPAPLNQGPVEARSLSSITAIASNPPNYPRNPAQKKLDPLVLYIVRVPGSKDVFLTPLKPPTKSSVSAEAINASLYYLHVASPDDEILLQEYEQEREERARLRKEGLIDDDPDLPIPPLEVARLNNVRRKPVAVAGTGGGAGMKDTESPTTAPSSPVKRRPLPSELPVQEGENKSSLLIGEEASPVLPPRPTSFNVPNQAGAVDQMSPVLPPRPVSNTPLPANGLEYPPPMPPRPSPSVPACEASSDKRASPKKNNRWSALSGYISNHIQRGDRHEAASPLRHSFDVSRPQMRPSSSHDLFAPYSPPGYSSRSPGQSPTRRPRDSASPLQPQPGFHITLIRRDPSHGSQWNVATMSTPSADSTGIDIDVSTPGYSRFAGQNEPFSLDSLGLNLPAEARNLLSRHPNIVSQSDSPDTTSAPRDPSQPRRFHRKLLVSRPHNLEDARNSRGSLDVSGGRPSMDSISGSSINSHQPASSKLKSGYYTFTSPWNGTCTFSASVNGRSLKCKHMIPSPGLPNSNHDNPAVTVAELRFNTPFQTGHLQYPGSSHASPFLLSQTTLLKDPSANPDPSAPYYFDPSSPPPSKRAAIANLINQRLNRRLSNSSSSDGGGNEAPPPLPTRPPPSDQRIDLSLAREKAGGGMRGDSAKLGKLIIEDEGIKMLDLVVAASMAVWWRGYYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B271</accession>
    <accession>C8VGR5</accession>
    <name>Q5B271_EMENI</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_05359</name>
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    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
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    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the trichodiene synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF82039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_657871.1"/>
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    <dbReference type="VEuPathDB" id="FungiDB:AN5359"/>
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    <dbReference type="OMA" id="FPQERYL"/>
    <dbReference type="OrthoDB" id="2998174at2759"/>
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        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016838">
        <property type="term" value="F:carbon-oxygen lyase activity, acting on phosphates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
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    <dbReference type="InterPro" id="IPR024652">
        <property type="entry name" value="Trichodiene_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06330">
        <property type="entry name" value="TRI5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF82039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="210" mass="24181" checksum="0447A4DCEE952438" modified="2005-04-26" version="1">MDKISVQDLANILVDFLKRFNYNDTARLPSEELKPLYDFVLPYIPYNEKIVRELAEYAHCTFPFLPLEVRQAVALYDTFQMSVDDLPVEQYDSLHDLCVQLSSGETVKHPVWNGFFNSLPILLQYYGPYAQTTLFRGALEFIQATCLERTLFRGFPGSSYPSYVRRMSGQGPVQAAVCFPEAEFPQEQYLPLIASLEAELEYCRLENMTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B280</accession>
    <accession>C8VGS6</accession>
    <name>Q5B280_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RTA1 domain protein, putative (AFU_orthologue AFUA_6G14140)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ANIA_05350</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
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            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF82056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_662954.1">
        <property type="nucleotide sequence ID" value="XM_657862.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B280"/>
    <dbReference type="GeneID" id="2871642"/>
    <dbReference type="KEGG" id="ani:ANIA_05350"/>
    <dbReference type="eggNOG" id="ENOG502QU4U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033465_6_1_1"/>
    <dbReference type="InParanoid" id="Q5B280"/>
    <dbReference type="OMA" id="MEMAGYI"/>
    <dbReference type="OrthoDB" id="4521223at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF8">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14140)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="130"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="166"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="254"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBF82056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="289" mass="31591" checksum="0A422AA486610338" modified="2005-04-26" version="1">MASYETCHEVSPLCPVEATTYGYYPNFGGNVFFAVWFGLLGVIQLGIGTYYRSWTIMIALAVGPLMELAGYIGRILMNDNPWNGDAFKLQIVCLVLAPTFIAAGIYLTLKHIILALGPEHSRLKPKLFTWIFICCDIGSLILQAAGGGVAAAAGNDMEVLKIGDDIIIAGIAFQVATMSVCGLLAAEFFWRVRKSGPGSFSEKSLGRRSIHLILFGEIFAYFTVLIRCIYRDNCSIPEMAGGWGNPLMQKEKEFLVLDGMMIGLAVLSLTVFHPSFFLPSLRKGVKAQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="104" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B2N7</accession>
    <accession>C8VF67</accession>
    <name>Q5B2N7_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aminotransferase function, hypothetical (Eurofung)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ANIA_05193</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF81054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_662797.1">
        <property type="nucleotide sequence ID" value="XM_657705.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B2N7"/>
    <dbReference type="STRING" id="227321.Q5B2N7"/>
    <dbReference type="GeneID" id="2871484"/>
    <dbReference type="KEGG" id="ani:ANIA_05193"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN5193"/>
    <dbReference type="eggNOG" id="KOG0257">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_4_4_1"/>
    <dbReference type="InParanoid" id="Q5B2N7"/>
    <dbReference type="OMA" id="IMAARDY"/>
    <dbReference type="OrthoDB" id="7042322at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43510">
        <property type="entry name" value="AMINOTRANSFERASE FUNCTION, HYPOTHETICAL (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43510:SF1">
        <property type="entry name" value="AMINOTRANSFERASE FUNCTION, HYPOTHETICAL (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="3">
        <location>
            <begin position="58"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBF81054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="409" mass="45279" checksum="035E06AE0519D7D1" modified="2005-04-26" version="1">MVQIKDFAVEQWMDKYETTAKYNVAETCSASISVRDLQALCEDPALNPLDGVLDRKLTYGEIRGSKQLRSTLANLYSVRTPTPLPSDNILVTAGAIQANFLLLYTLVGPGDHVICHYPTYQQLYSVPESLGAEVSLWKSKEAEGWKLDLEELKGLIRPNTKLIIINNPQNPTGAIIPQGTLDEIVEIARSSSIYVFCDEVYRPLFHSISPMDPDFPSSVLSLGYERAIVTGSLSKAYSLAGIRVGWIASRDRTVIEACASSRDYTTISVSQLDDAVASYALAPTTIHALLKRNIELGRTNLGILEKFIESHRWACDWVKPRAGTTAFVRFNKMGKPVNDTAFCEMLLERTGVMLVPGSLCFGGGEDFLGYVRIGYVCETQVLEEGLAKLKAFLEDDYEEVPAVKRKTQS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-05-30" modified="2026-01-28" version="105" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B3I8</accession>
    <accession>C8V9S5</accession>
    <name>RNA14_EMENI</name>
    <protein>
        <recommendedName>
            <fullName>mRNA 3'-end-processing protein rna14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">rna14</name>
        <name type="ORF">AN4892</name>
    </gene>
    <organism>
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the cleavage factor IA (CFIA) complex, which is involved in the endonucleolytic cleavage during polyadenylation-dependent pre-mRNA 3'-end formation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="1">Nucleus and/or cytoplasm.</text>
    </comment>
    <comment type="sequence caution" evidence="3">
        <conflict type="erroneous gene model prediction">
            <sequence resource="EMBL-CDS" id="EAA60970" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EMBL" id="AACD01000084">
        <property type="protein sequence ID" value="EAA60970.1"/>
        <property type="status" value="ALT_SEQ"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF76536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B3I8"/>
    <dbReference type="SMR" id="Q5B3I8"/>
    <dbReference type="FunCoup" id="Q5B3I8">
        <property type="interactions" value="1158"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5B3I8"/>
    <dbReference type="EnsemblFungi" id="CBF76536">
        <property type="protein sequence ID" value="CBF76536"/>
        <property type="gene ID" value="ANIA_04892"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1914">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007630_1_1_1"/>
    <dbReference type="InParanoid" id="Q5B3I8"/>
    <dbReference type="OMA" id="VQLWSVY"/>
    <dbReference type="OrthoDB" id="26282at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.1040:FF:000006">
        <property type="entry name" value="CFIA complex component Rna14, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045243">
        <property type="entry name" value="Rna14-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008847">
        <property type="entry name" value="Suf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19980:SF0">
        <property type="entry name" value="CLEAVAGE STIMULATION FACTOR SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19980">
        <property type="entry name" value="RNA CLEAVAGE STIMULATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05843">
        <property type="entry name" value="Suf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0507">mRNA processing</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <feature type="chain" id="PRO_0000238524" description="mRNA 3'-end-processing protein rna14">
        <location>
            <begin position="1"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="repeat" description="HAT 1">
        <location>
            <begin position="270"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="repeat" description="HAT 2">
        <location>
            <begin position="304"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="repeat" description="HAT 3">
        <location>
            <begin position="346"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="repeat" description="HAT 4">
        <location>
            <begin position="395"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="repeat" description="HAT 5">
        <location>
            <begin position="465"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="repeat" description="HAT 6">
        <location>
            <begin position="510"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="20"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="215"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="621"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="840"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="120"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="868"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="885"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="925"/>
            <end position="940"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="1075" mass="120475" checksum="DC3053CB5502F956" modified="2011-10-19" version="2">MAEDDAEKAFFEAQAMNAGSMGYNGAEDQNANASDSDEYDPSSTLQDQYPAPSENLQLQETDTPTSVSQPQPSFREDADPAGNAHPSQPPSRPESQASTSVPATGVSVQPKTRTIGGFVVEDEDEDDAGDADYEPPAVLGVEDMNIIPSQPIPGNANEATSTPDVSLDEAAQESASAKNVPNSSLSSVSLAFKNDGSMDLGQNLYNSRTSLQPEIARESATATPAPDSPSTAKGRLPHDRVGILEDRIREDPRGDIPAWLELINEHRSRNRIDSARDVYERFLKVFPLSAEMWVAYATMESELNELFRLEQIFNRTLLTIPAVQLWTVYLDYVRRRNPLSTDTTGQARKVISSAYELALQHIGMDKESGSIWADYIQFIRSGPGNVGGSGWQDQQKMDLLRKAYQRAICVPMQAVNTLWKEYDQFEMGLNKLTGRKFLQEQSPSYMTARSSYTELQNFTRDLNRTTLPRLPPVPGSEGDFEYLQQIEIWKRWINWEKGDPLVLKEDDLTAYKGRVVYVYKQALMALRFLPEIWFEAADFCFLNDMETEGNEFLKNGIDANPESCLLAFKRADRLEITSESEQDPIKRGAKVREPYDRLLDALYDLIAKARTREAQDVARLEETFKLRPDTQPAANDDDDDDQSETKAKESVKNAQIEAVRHAHSIQIGILSKTVSFAWIALMRAMRRIQGKGKPGEVPGSRQVFADARKRGRITSDVYIASALIEYHCYKDPAATKIFERGAKLFPEDENFALEYLKHLIDINDIINARAVFEMTVRKLAANPENVHKTKPIFAFLHEYESRYGDLVQVINLETRMRELFPDDPTLEQFAHRFSAPNFDPTTFRPIISPSQTRPKTVYPGGQVPSRHGTPSSRFPEASVTNSPKRPLEDFDDDMSRPRKFVRGESPLRTTTQRRQLDQQKRTQTALQVPSSGSQYRSQGSPAPLPRDIVYLLSVIPPASTYTAGRFSAEKMIDLVRRLDLPASISQIPLPQSARGLGTGQTTIGGQQFSDDGGYYYKGGVVDMCALHFMDDGVFRLYVAGLAGNILARILFFGSGGLLAYLLRTVQIWDPEIPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B3T4</accession>
    <accession>C8VAM2</accession>
    <name>Q5B3T4_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7704 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_04796</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF76765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_662400.1">
        <property type="nucleotide sequence ID" value="XM_657308.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B3T4"/>
    <dbReference type="STRING" id="227321.Q5B3T4"/>
    <dbReference type="GeneID" id="2872594"/>
    <dbReference type="KEGG" id="ani:ANIA_04796"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN4796"/>
    <dbReference type="eggNOG" id="ENOG502S8N7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112091_3_2_1"/>
    <dbReference type="InParanoid" id="Q5B3T4"/>
    <dbReference type="OMA" id="DPWAWQN"/>
    <dbReference type="OrthoDB" id="2937326at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056121">
        <property type="entry name" value="DUF7704"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37019">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37019:SF2">
        <property type="entry name" value="EXPERA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24803">
        <property type="entry name" value="DUF7704"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7704" evidence="2">
        <location>
            <begin position="3"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF76765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="161" mass="17363" checksum="8F6209DB358AC21E" modified="2005-04-26" version="1">MPATILPTWPHIVFAIFEPITLIGGWLAPIFDLQGFIVGQIPLSPAPEELEVQATSFALAYQLANVYGLMALLGAGVLYATSEPKVLRNYLVALAIGDVGHIYVTYLAMGPALFFDVGGWNALTWGNVGVTAFLFVNRLLYCLGVFGYAEGGSVKEPKKRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="111" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B3V3</accession>
    <accession>C8VAP1</accession>
    <name>Q5B3V3_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">40S ribosomal protein S27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ANIA_04777</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the eukaryotic ribosomal protein eS27 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF76802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_662381.1">
        <property type="nucleotide sequence ID" value="XM_657289.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B3V3"/>
    <dbReference type="FunCoup" id="Q5B3V3">
        <property type="interactions" value="828"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5B3V3"/>
    <dbReference type="GeneID" id="2872578"/>
    <dbReference type="KEGG" id="ani:ANIA_04777"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN4777"/>
    <dbReference type="eggNOG" id="KOG1779">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130128_3_0_1"/>
    <dbReference type="InParanoid" id="Q5B3V3"/>
    <dbReference type="OMA" id="CASILCQ"/>
    <dbReference type="OrthoDB" id="5567124at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.100:FF:000001">
        <property type="entry name" value="40S ribosomal protein S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.100">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00371">
        <property type="entry name" value="Ribosomal_eS27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000592">
        <property type="entry name" value="Ribosomal_eS27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023407">
        <property type="entry name" value="Ribosomal_eS27_Zn-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11594">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01667">
        <property type="entry name" value="Ribosomal_S27e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01168">
        <property type="entry name" value="RIBOSOMAL_S27E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBF76802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="82" mass="8910" checksum="91EA459F5768EC5C" modified="2005-04-26" version="1">MVLAVDLLNPTPQAEARKHKLKQLVPGPRSFFMDVKCPGCFNITTVFSHAQTVVVCSGCSTVLCQPTGGKARLTEGCSFRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B3Z9</accession>
    <accession>C8VAU4</accession>
    <name>Q5B3Z9_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">20S proteasome maturation protein Ump1, putative (AFU_orthologue AFUA_5G10740)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ANIA_04731</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the POMP/UMP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF76906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_662335.1">
        <property type="nucleotide sequence ID" value="XM_657243.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B3Z9"/>
    <dbReference type="FunCoup" id="Q5B3Z9">
        <property type="interactions" value="387"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5B3Z9"/>
    <dbReference type="GeneID" id="2872532"/>
    <dbReference type="KEGG" id="ani:ANIA_04731"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN4731"/>
    <dbReference type="eggNOG" id="KOG3061">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100687_0_0_1"/>
    <dbReference type="InParanoid" id="Q5B3Z9"/>
    <dbReference type="OMA" id="MSMRIVP"/>
    <dbReference type="OrthoDB" id="15001at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008012">
        <property type="entry name" value="Ump1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12828:SF3">
        <property type="entry name" value="PROTEASOME MATURATION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12828">
        <property type="entry name" value="PROTEASOME MATURATION PROTEIN UMP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05348">
        <property type="entry name" value="UMP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="11"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00043974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBF76906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="166" mass="18360" checksum="AC1AA8CE873A7935" modified="2005-04-26" version="1">MSLRIAPPSSHPTQTSNTSTRHLPNTHTSRGAPSAPGVPDTLRSNITLQAPRGAPSTQPATPTSTHPLEARLLAWRQTQDALKMEGLRRTYGIAEPVRRGMELKIVRDGTFRPAVLGGNKLGNVHEDILVLGGRDTEIGWEDVFHGDDFREPPSFHDEMEKRLRMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="100" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B4I8</accession>
    <accession>C8V885</accession>
    <name>Q5B4I8_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">C2H2 finger domain protein, putative (AFU_orthologue AFUA_2G02730)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ANIA_04542</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF77290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_662146.1">
        <property type="nucleotide sequence ID" value="XM_657054.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B4I8"/>
    <dbReference type="STRING" id="227321.Q5B4I8"/>
    <dbReference type="GeneID" id="2872331"/>
    <dbReference type="KEGG" id="ani:ANIA_04542"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN4542"/>
    <dbReference type="eggNOG" id="ENOG502S997">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033337_0_0_1"/>
    <dbReference type="InParanoid" id="Q5B4I8"/>
    <dbReference type="OMA" id="EHTPEWA"/>
    <dbReference type="OrthoDB" id="2152896at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="92"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="223"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="350"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="413"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="233"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="259"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="371"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="428"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBF77290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="460" mass="48873" checksum="72B22474730C4E5B" modified="2005-04-26" version="1">MASFKELSLSRPFPQSAPRHHSHSISLGAVNSNHRVTRRKSVTTTAAANAAAAVAATLKDSPDSVAIAMPAHRRGSRKGLESSSVGATSTFSSSYLSRSINSPSRDSMVARKTSPGQLHESAPTAQTAVDGSVAPGKPISTKNRNRRASEGGHMVKGEGKSSRPELRCDRCGKGYKHGSCLSKHMWEHDPAWAITSKLLISKHQQVQLLEAASVLVNMNVEEPTTANPDAESETSSASPDASSELRDGLSSAETTPPPMDEDNSDDDMSIEPEKPFGVNNAAPQYSHSFQSVPASSFTGSAPWPSPGFSHFRHSSIDARPPTAEAKLADDDEADLAAAIGLCNFGTPRMGPTSASPGVPPVPPLPSRFLDQASSSENRNFGRSGSGASVTDTTLGNSHQDMFLSLSYNPSMSYKVSDEREARLGNTERSSRQTRNADVDFGSRPAHADDDDDGVFGRMEE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-05-31" modified="2025-06-18" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B4W9</accession>
    <accession>C8V8T1</accession>
    <name>STS1_EMENI</name>
    <protein>
        <recommendedName>
            <fullName>Tethering factor for nuclear proteasome sts1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">sts1</name>
        <name type="ORF">AN4411</name>
    </gene>
    <organism>
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in ubiquitin-mediated protein degradation. Regulatory factor in the ubiquitin/proteasome pathway that controls the turnover of proteasome substrates. Targets proteasomes to the nucleus and facilitates the degradation of nuclear proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Binds the proteasome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cut8/STS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="AACD01000076">
        <property type="protein sequence ID" value="EAA60328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF77582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_662015.1">
        <property type="nucleotide sequence ID" value="XM_656923.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B4W9"/>
    <dbReference type="SMR" id="Q5B4W9"/>
    <dbReference type="FunCoup" id="Q5B4W9">
        <property type="interactions" value="10"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5B4W9"/>
    <dbReference type="EnsemblFungi" id="CBF77582">
        <property type="protein sequence ID" value="CBF77582"/>
        <property type="gene ID" value="ANIA_04411"/>
    </dbReference>
    <dbReference type="KEGG" id="ani:ANIA_04411"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN4411"/>
    <dbReference type="eggNOG" id="ENOG502RNK4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033658_0_0_1"/>
    <dbReference type="InParanoid" id="Q5B4W9"/>
    <dbReference type="OMA" id="DYTPHFL"/>
    <dbReference type="OrthoDB" id="10061064at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071630">
        <property type="term" value="P:nuclear protein quality control by the ubiquitin-proteasome system"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031144">
        <property type="term" value="P:proteasome localization"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1590:FF:000001">
        <property type="entry name" value="Tethering factor for nuclear proteasome STS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1590">
        <property type="entry name" value="Tethering factor for nuclear proteasome Cut8/Sts1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013868">
        <property type="entry name" value="Cut8/Sts1_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038422">
        <property type="entry name" value="Cut8/Sts1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28032">
        <property type="entry name" value="FI02826P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28032:SF1">
        <property type="entry name" value="FI02826P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08559">
        <property type="entry name" value="Cut8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-0653">Protein transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000409411" description="Tethering factor for nuclear proteasome sts1">
        <location>
            <begin position="1"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="20"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="40"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="315" mass="34592" checksum="9F6CBCB5430994EB" modified="2005-04-26" version="1">MNSLVATPPVPPHIYEYSRLSPSRPMSTPSHTPTTNRKRKAEDEHNDFDSRMSASPTNSPAFTPRTLPSSSRQIKRARPNMGGRPLSLPRLLETLDTDALRGVLRSICDRHPNLADEVVQTAPRPSVASALQVLRNYQSALQSSFPLGGNPESDYAYNRVRQPLGNLLEALSDFTPHFLPPNETQPSISLSYLDDVTEIIHQLPRWSSPQNNIERDSAYDEICKAWILVIREAAKRGGGIQLQYGGWDQKLAKHNQNSGGRLQAAVNDLASSLGWMHGPESQGFGSPGGNDLGSIREQLLSGTYGLGTPVKVGPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B5D6</accession>
    <accession>C8V435</accession>
    <name>Q5B5D6_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BCAS2 family protein (AFU_orthologue AFUA_1G06460)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ANIA_04244</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SPF27 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF74404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_661848.1">
        <property type="nucleotide sequence ID" value="XM_656756.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B5D6"/>
    <dbReference type="STRING" id="227321.Q5B5D6"/>
    <dbReference type="GeneID" id="2873667"/>
    <dbReference type="KEGG" id="ani:ANIA_04244"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN4244"/>
    <dbReference type="eggNOG" id="KOG3096">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082523_4_0_1"/>
    <dbReference type="InParanoid" id="Q5B5D6"/>
    <dbReference type="OMA" id="SAWQESI"/>
    <dbReference type="OrthoDB" id="205794at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008409">
        <property type="entry name" value="SPF27"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13296">
        <property type="entry name" value="BCAS2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13296:SF0">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR SPF27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05700">
        <property type="entry name" value="BCAS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="135"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBF74404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="215" mass="24045" checksum="07938B6B36B824EC" modified="2005-04-26" version="1">MPLVDESHDSLPYIDATPSAEARAYAEKLIASELSSDYQTSVHPSIPEFPEPKFSPLIQQEIERKAAGLPLTGGIDLARYEAPEPPTRSADSAPNLDEWRQTLRRAYTASSHLSSRQENLSLLEESGKNAWLIGNSQLEDILRALEKELAETKEATESVNKQRKIAQESCQGEITGLEESWRRGVGAILDVELAAEDLRMKILEQRRQHAQQQAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B5N1</accession>
    <accession>C8V4Y2</accession>
    <name>Q5B5N1_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_04149</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF74605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_661753.1">
        <property type="nucleotide sequence ID" value="XM_656661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B5N1"/>
    <dbReference type="GeneID" id="2873571"/>
    <dbReference type="KEGG" id="ani:ANIA_04149"/>
    <dbReference type="eggNOG" id="ENOG502ST92">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029473_1_1_1"/>
    <dbReference type="InParanoid" id="Q5B5N1"/>
    <dbReference type="OMA" id="ITYDGRW"/>
    <dbReference type="OrthoDB" id="5333491at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010317656" description="F-box domain-containing protein" evidence="2">
        <location>
            <begin position="31"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="345"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF74605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="514" mass="58604" checksum="76C13BFD5DDBF091" modified="2005-04-26" version="1">MAGMNSLSLELIELIVLELVKLLFHDSADGIPGRETHHLLAPYARISRKFQVAVERFLYRSVQTSSSVQRELDAIRASPSRRAALRDLVYVIELPAYDSELLYAMERRREHRANQDSFRNGLVKIWHELSGWDKPPSLFLDLSASSPSDDCSAFDSENRWLLPEHSLSIDTNESLKLPKIECMISLAVGKQGRRIHPATVYEMILTLPNLRVLDWTMASVQLRYKALRAEYSAILAKALQAPTLVKLEVLSLSLTECPPNNHDFDMGLERDPTYPDGDMLSLAIRELAQRNLRELNLDQVPISPALFGSSDTDVNTSFPHLEHVRIKFPIITYDGRWYYAGNRDSVNPEELDPEEQMQIDNGPSLEEPDSDIESDISLNMDRADFLNGKIPWYNWRTHPDPTMFNTLIRSVVAATHRMPKLKNLLLTTKVRGLSTCDYEDELERQWTIKANYATPGCYIGTLRYPNMSVQADSRCRWVVNLGPRVQWEVPSDIQGMMKEKVGDGGDLVIYRSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B5U6</accession>
    <accession>C8V5C6</accession>
    <name>Q5B5U6_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Capsule-associated protein CAP1, putative (AFU_orthologue AFUA_1G05595)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_04084</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF74742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_661688.1">
        <property type="nucleotide sequence ID" value="XM_656596.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B5U6"/>
    <dbReference type="CAZy" id="GT90">
        <property type="family name" value="Glycosyltransferase Family 90"/>
    </dbReference>
    <dbReference type="GeneID" id="2873507"/>
    <dbReference type="KEGG" id="ani:ANIA_04084"/>
    <dbReference type="eggNOG" id="KOG2458">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005027_4_1_1"/>
    <dbReference type="InParanoid" id="Q5B5U6"/>
    <dbReference type="OMA" id="HQPTWTH"/>
    <dbReference type="OrthoDB" id="541052at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006598">
        <property type="entry name" value="CAP10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051091">
        <property type="entry name" value="O-Glucosyltr/Glycosyltrsf_90"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203">
        <property type="entry name" value="KDEL LYS-ASP-GLU-LEU CONTAINING - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203:SF104">
        <property type="entry name" value="PROTEIN CAP1, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05595)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05686">
        <property type="entry name" value="Glyco_transf_90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00672">
        <property type="entry name" value="CAP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010223174" evidence="1">
        <location>
            <begin position="22"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase CAP10" evidence="2">
        <location>
            <begin position="307"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF74742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="585" mass="67432" checksum="AFB43C7E8EA4DFC2" modified="2005-04-26" version="1">MATRSHRLLGVLVTSLLVCLSLIFLESPSSFSNRNIAPSPPSTSLTPFLQPSEPLDDTIDRFPSDIHPVTALVEDAEQRFNKLLERQSRTLSDAVKEYRRRYNMHPPPHFDKWFSFARSKGVELIDEYDTIYHSLLPFWALTPQTIRARAREALGYDNGLFGVLIRDGKVSLAEGLDGEHEWQREATLGMMKNFIRYLPDMDLAFNAHDEPRVIVPSEDLQRLVAIAKNSVIPNAFKAKSLVNEWSARPEDLNKGDRIDEVRTTRFNKISHQPAWTSSRISCPVDSPVRSLDENSPDDTTGYASWELGFIHNTTAFSDVCNTPSLRYTYGFFDRPNVFAVVHDLFPVFSQSKVSTFQDILYPSPWYWANKVPYNMQNDYIWEEKIDKLYWRGSTTGGFSKGGGWRRHHRQLMVSNINALDNAKVLSKTDGGQWEVKEMDRSEYRDLFDVQFTSVGQCDRNDCAAQMEFFNITESVEQEEAWAYKYLLDIDGNAFSGRYHAFLKSNSLVCKTALFREWHDERLKPWVHYVPISLKGSELLETMRYLSSEEEGEVVASRIAQNGKAWAQSTLRNEDMEVWFFRLLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B607</accession>
    <accession>C8V5P3</accession>
    <name>Q5B607_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">4-carboxymuconolactone decarboxylase family protein (AFU_orthologue AFUA_1G03690)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_04023</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF74866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_661627.1">
        <property type="nucleotide sequence ID" value="XM_656535.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B607"/>
    <dbReference type="GeneID" id="2873445"/>
    <dbReference type="KEGG" id="ani:ANIA_04023"/>
    <dbReference type="eggNOG" id="ENOG502RZ3K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082760_2_0_1"/>
    <dbReference type="InParanoid" id="Q5B607"/>
    <dbReference type="OMA" id="RVAVCNK"/>
    <dbReference type="OrthoDB" id="9998495at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003779">
        <property type="entry name" value="CMD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34846:SF9">
        <property type="entry name" value="4-CARBOXYMUCONOLACTONE DECARBOXYLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_1G03690)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34846">
        <property type="entry name" value="4-CARBOXYMUCONOLACTONE DECARBOXYLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G11590)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02627">
        <property type="entry name" value="CMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxymuconolactone decarboxylase-like" evidence="1">
        <location>
            <begin position="46"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF74866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="179" mass="19503" checksum="4EA92185E785B87C" modified="2005-04-26" version="1">MRLPYVADPPPTSTPEEAEILARVQTRRAPNGLLPLDRALLHSFPVADGWNSFLGAIRQRTSLSSVIRELVISRVAIVNGALFEWEQHSPLLSQAGLSDAALQVVEDADADIAAKVLEGVLTPAEGAVLSYTDAMTKTVTVRDEIFEAVKERFNEREVVEITATAAAYNCYARKAQSII</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B679</accession>
    <accession>C8V624</accession>
    <name>Q5B679_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_03951</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF75024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_661555.1">
        <property type="nucleotide sequence ID" value="XM_656463.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B679"/>
    <dbReference type="STRING" id="227321.Q5B679"/>
    <dbReference type="GeneID" id="2873373"/>
    <dbReference type="KEGG" id="ani:ANIA_03951"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN3951"/>
    <dbReference type="eggNOG" id="ENOG502RXJJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012627_1_0_1"/>
    <dbReference type="InParanoid" id="Q5B679"/>
    <dbReference type="OMA" id="GMPYKYV"/>
    <dbReference type="OrthoDB" id="2163491at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035516">
        <property type="term" value="F:broad specificity oxidative DNA demethylase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051747">
        <property type="term" value="F:cytosine C-5 DNA demethylase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA alkylation repair"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032852">
        <property type="entry name" value="ALKBH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31573">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31573:SF4">
        <property type="entry name" value="FE2OG DIOXYGENASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="2">
        <location>
            <begin position="489"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="520"/>
        </location>
        <ligand>
            <name>2-oxoglutarate</name>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="641"/>
        </location>
        <ligand>
            <name>2-oxoglutarate</name>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="652"/>
        </location>
        <ligand>
            <name>2-oxoglutarate</name>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="656"/>
        </location>
        <ligand>
            <name>2-oxoglutarate</name>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="658"/>
        </location>
        <ligand>
            <name>2-oxoglutarate</name>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR632852-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF75024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="686" mass="77100" checksum="CF05B11D4A0B328C" modified="2005-04-26" version="1">MARPKKGPIAPRTVSNRVIPPLTGIEPSRDAVFDPSDVASDAKVRSIESSPSLAEVDGVPPAWADVREPEDRAALASAIPWFTCYEGGMYHSKMVCYGFLLDGDSGNRCHIDDEVVITRIGGGCSKDRDGNLMLKKDMDEQDVTVRSLANRSKNTSLGRKLPHRYNVMAYFRVICIWAEKINGKTGYKVRFEKLDLSEKSWWAEKGTALPDPASRRFTQAESRQCATCLTPSTHVYKEGWMCLNRTCQEFWMLAGLEPPRNLTFDDRFLEARAQPGPDMQLHGDLIPDLLSTIDEHDPLGSSSPLSWKSGVVCPLCQKCIPRRFWNGWKCSDTLSGKAQGECPFEKWLKIPTVPLSAAIGGINLCRNKRTVIKNRQSSFLPQIDDRSFAPYKLITYGLGASGYIMHFVSNEVINSRPRGPNELFEELQKANLGLRRYPLDQAQVAGTLTAHFVTNFGAPYKYVVSVDSRGFSEACDPVLRALGRLTWATKNAVRSQGGNTYDPNELLLLGYFEEQKIGYHDDGESSLGPTIATLSLGSPATMAVRMKYKYYHGFTKAGREKNTLLTDDPILPECENYVNRQKLKERLLNGSITDDEYKKAWFDSFAENKSRNLPPDIIKIKLNHGDMVVMHGEGVQKYYEHGVKLEKRGKLRFALTARHVKKEEIPEQDWPKGDFTLTDDQIYDGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="106" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B6F9</accession>
    <accession>C8V6F9</accession>
    <name>Q5B6F9_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Single-strand DNA deaminase toxin A-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ANIA_03871</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF75199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_661475.1">
        <property type="nucleotide sequence ID" value="XM_656383.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B6F9"/>
    <dbReference type="STRING" id="227321.Q5B6F9"/>
    <dbReference type="GeneID" id="2873288"/>
    <dbReference type="KEGG" id="ani:ANIA_03871"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN3871"/>
    <dbReference type="eggNOG" id="KOG2319">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042425_0_0_1"/>
    <dbReference type="InParanoid" id="Q5B6F9"/>
    <dbReference type="OMA" id="RDHYKNR"/>
    <dbReference type="OrthoDB" id="341259at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057517">
        <property type="entry name" value="SsdA-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24120">
        <property type="entry name" value="SsdA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="182"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="215"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="Single-strand DNA deaminase toxin A-like C-terminal" evidence="5">
        <location>
            <begin position="359"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="258"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBF75199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="585" mass="67802" checksum="C3BC11C3A70FACAB" modified="2005-04-26" version="1">MSSVRTQPLAEVVWWTDEQFCVRCPYCEELHRHGLNSSSSTSTVVSRDYPRTSRVPHCAFATTRPPYECSFPVDYEIDKPKARFVNIRTLMDLQEDEKEESDDEASLTSLLSYLALTDTKKEVFFDHSTEEITIQMEVQEPFTQRRILHAISDCCMGDVKRVKHYLETSPDKSIFLHGKDTEGDTCLIMASRERTPAMVSLLLENGAEVNASNNNGRTALMEAALWGRLETVEILLSHGANKTLRDTNKKRALDLAQPTRQNRDERHIAAGGALGDSSQKPLYNEDVVNRDADRREIARILEGGQSGSGTDNHARMFELDENFFRRSSDDLLISYYSMPRSRKTVAVLERDGYFPPKASMSGWAHDEGRYLTERVMKISKIVGHNLRLDDRYDQGQPGKFYASHAEKQLIAYFIDRHVFLQEDKTQNPQFFKRIEHLEHEISVMVDRYPDVRKFDQLRKDKKELDLQLLDKDDRLLGNEYDEGLVKQLKEEVATIDRELVTLKGQREVVQLLRKEKEIQKCEDNWKLHERLNRLSERAPTNILKRATILITAPSYKVCDDCREFNRRINQDLGLSIQLYERTQHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B8E0</accession>
    <accession>C8VIC2</accession>
    <name>Q5B8E0_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endoplasmic reticulum junction formation protein lunapark</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ANIA_03190</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays a role in determining ER morphology.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">The C4-type zinc finger motif is necessary both for its ER three-way tubular junction localization and formation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the lunapark family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF83226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_660794.1">
        <property type="nucleotide sequence ID" value="XM_655702.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B8E0"/>
    <dbReference type="STRING" id="227321.Q5B8E0"/>
    <dbReference type="GeneID" id="2874440"/>
    <dbReference type="KEGG" id="ani:ANIA_03190"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN3190"/>
    <dbReference type="eggNOG" id="KOG2846">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039522_1_0_1"/>
    <dbReference type="InParanoid" id="Q5B8E0"/>
    <dbReference type="OMA" id="CGYFNPS"/>
    <dbReference type="OrthoDB" id="1725934at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071782">
        <property type="term" value="C:endoplasmic reticulum tubular network"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098826">
        <property type="term" value="C:endoplasmic reticulum tubular network membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071788">
        <property type="term" value="P:endoplasmic reticulum tubular network maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071786">
        <property type="term" value="P:endoplasmic reticulum tubular network organization"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903373">
        <property type="term" value="P:positive regulation of endoplasmic reticulum tubular network organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040115">
        <property type="entry name" value="Lnp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019273">
        <property type="entry name" value="Lunapark_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22166">
        <property type="entry name" value="ENDOPLASMIC RETICULUM JUNCTION FORMATION PROTEIN LUNAPARK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22166:SF12">
        <property type="entry name" value="ENDOPLASMIC RETICULUM JUNCTION FORMATION PROTEIN LUNAPARK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10058">
        <property type="entry name" value="Zn_ribbon_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="Lunapark zinc ribbon" evidence="3">
        <location>
            <begin position="243"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="139"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="316"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="151"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="182"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="362"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU367073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBF83226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="399" mass="44412" checksum="0ABB49EC95AE433F" modified="2005-04-26" version="1">MVSLWPFKGEDTSPAGFEKALSALSEKITQTTTRLDLHRQHARRFKALWTLYTTFIYLLYSIILALVLGWENWGVKEYAAVLGGPVIIYLVRAGGTMFFEYRINHTQRYLDSLQKQRDETIEKLKVATKYNSTQQLLEKYAGDSPKPSRSKGGDHKPKPENKRKPSGQQQQPPQPQFHRTGLPPPPTANIRRPVPPPPEQPPSPYPSQQYQQPRPNMPPPGLDEPGFAPNAFPTQQYIEQSRWYDRLLDVLLGEDETQPKNRIVLICAACRLVNGQAPPGVKSLEEIGRWRCGGCGAWNGEDSAARKVLADIKAAAGPVSEPSDGEAETEHRFSTSTSDGASDGVIVTKEDDEQERNEVEVESQSGSGSGAETPAEDDEPASKIRTRSQNVTKRRARKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B938</accession>
    <accession>C8VJ39</accession>
    <name>Q5B938_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_02942</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF83706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_660546.1">
        <property type="nucleotide sequence ID" value="XM_655454.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B938"/>
    <dbReference type="ESTHER" id="emeni-q5b938">
        <property type="family name" value="6_AlphaBeta_hydrolase"/>
    </dbReference>
    <dbReference type="GeneID" id="2873969"/>
    <dbReference type="KEGG" id="ani:ANIA_02942"/>
    <dbReference type="eggNOG" id="ENOG502S15T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046066_1_3_1"/>
    <dbReference type="InParanoid" id="Q5B938"/>
    <dbReference type="OMA" id="EYEPWHD"/>
    <dbReference type="OrthoDB" id="1263307at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052897">
        <property type="entry name" value="Sec-Metab_Biosynth_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37017">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37017:SF11">
        <property type="entry name" value="ESTERASE_LIPASE_THIOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="12"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF83706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="245" mass="26563" checksum="B0D92DCCE61C24CF" modified="2005-04-26" version="1">MATKPTIVFSIGAWLTPPAFNALRAKLLERCIPSEAPPHPSIGAEPPNKTLADDIASLSSVLKKLVEVEGKDVVVIGHSYGGVVASSAVEGLAKADRETAGQNGGVVRIAYMAAFVLDKGQSLLGMLGGQYLPWMEVKDDYVYCNAGAEAAMHDLTPEERQKWSSELVHTSRAVFSGASTYEPWHRIPSAYVLCEEDLALPLLFQEMMAAKLETDLTYRLKSSHSPFLSMPDSLTDVLEDLVSRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="124" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B988</accession>
    <accession>C8VJ91</accession>
    <name>Q5B988_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS sugar permease, putative (AFU_orthologue AFUA_6G12040)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ANIA_02892</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF83799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_660496.1">
        <property type="nucleotide sequence ID" value="XM_655404.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B988"/>
    <dbReference type="GeneID" id="2873964"/>
    <dbReference type="KEGG" id="ani:ANIA_02892"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN2892"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_11_0_1"/>
    <dbReference type="InParanoid" id="Q5B988"/>
    <dbReference type="OMA" id="SLWTAMS"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000078">
        <property type="entry name" value="MFS maltose transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF33">
        <property type="entry name" value="SUGAR PERMEASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G12040)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="186"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="308"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="343"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="371"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="398"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="436"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="470"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="52"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBF83799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="525" mass="57076" checksum="5F67CD5ABF826CB0" modified="2005-04-26" version="1">MGGKDTEAVAAHIEKATNVTDDAAERGRLIQEQERQLSLWATVKLHPRAVLACSVAFAAGAMFGYDQISNGSTIAMPAFMMYYGDHNESGLYLPSIWTSLWTSMTSLLQAVGAICVGMISDRFGRKWPGVMAGILSIVGTVVLYYAKSRGALLAGKMVCGLALGAGMAIGTTYASEVAPLKLRVPIQTILVVFIVFMQGLAMGIVRIFVPNTDEQAFRNVFAIQWAVGGIFAVTCLFAPESPVYLINSGRVDAAEKVMKKLYSSKFSIDDRLAYLVKTISEEQEQQRISAGSYLDCLRGSNLKRTLTVMFLYSTANLGGAAFLSQSIYFLLTLGLPSVHIFDISIGGFALAIIVILLTGFIGKFLSRRRMLLMGCLINLAFLVVIGCLYYASGMGPSWAIAVLMNILISIQTSLMQAVGWPIAAEISSYRLRVKSLSIGVFAQTLSTWVMTFTVPYMYNVDSGDLGARTAFPFAGITVLLVIGAYFLVPDTTGLSTEEIDRLYEDKVSPRRFSSFVTHDVPRVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B992</accession>
    <accession>C8VJ95</accession>
    <name>Q5B992_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_02888</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF83806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_660492.1">
        <property type="nucleotide sequence ID" value="XM_655400.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B992"/>
    <dbReference type="STRING" id="227321.Q5B992"/>
    <dbReference type="GeneID" id="2874034"/>
    <dbReference type="KEGG" id="ani:ANIA_02888"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN2888"/>
    <dbReference type="eggNOG" id="ENOG502SK1Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064110_0_0_1"/>
    <dbReference type="InParanoid" id="Q5B992"/>
    <dbReference type="OMA" id="GWLIWRV"/>
    <dbReference type="OrthoDB" id="5421757at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
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            <begin position="1"/>
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        </location>
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            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
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        <location>
            <begin position="13"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF83806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="365" mass="41108" checksum="E242941BBBBA520B" modified="2005-04-26" version="1">MARSARRSTKGKAPATSTPSSGSSTPSSQSGPIPPFTLAPECLTPFLKLLSPKEVYLLHIDSSALDLKKQAFIIPAVTNALIVALIAYRVYVGRTMYPELLATVLGLTDSANLDTSSLSFTELATLILRRALPVLFDYFLVVTFLPWPLQFCKGPFQWRRRVGFRNAEIIVRRSQSALSATLERNRWIGEDEEMRDKIVAAVTPDRLAKTGYLLIDADWDLDYEAMIKAHELTSSTNNPNQVPMDEFRTAVLVNTDNDGWIIWHVGDENTEEGRTRSKQRDQILAFKDKLTEMGHEELFFRWVELIQYESTQPGGFTPERQARAMLQAKQLFEDAGVDFTRFWQEVGGMEGFGDADGEESEDQLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="124" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B9N2</accession>
    <accession>C8VJX7</accession>
    <name>Q5B9N2_EMENI</name>
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        <submittedName>
            <fullName evidence="11">C2H2 transcription factor (TFIIIA), putative (AFU_orthologue AFUA_1G05150)</fullName>
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    <gene>
        <name evidence="11" type="ORF">ANIA_02748</name>
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        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
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        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="12">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="CBF84096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_655260.1"/>
    </dbReference>
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    <dbReference type="FunCoup" id="Q5B9N2">
        <property type="interactions" value="34"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5B9N2"/>
    <dbReference type="GeneID" id="2874473"/>
    <dbReference type="KEGG" id="ani:ANIA_02748"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002678_91_1_1"/>
    <dbReference type="InParanoid" id="Q5B9N2"/>
    <dbReference type="OMA" id="MLTGEGY"/>
    <dbReference type="OrthoDB" id="4748970at2759"/>
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        <property type="component" value="Chromosome VI"/>
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        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="Zinc_finger_trans_reg"/>
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        <property type="entry name" value="Znf_C2H2_sf"/>
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    <dbReference type="PANTHER" id="PTHR46179:SF13">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="73"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="103"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
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    <feature type="domain" description="C2H2-type" evidence="10">
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        </location>
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        </location>
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    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CBF84096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="585" mass="65305" checksum="5F42B64E133E8F0A" modified="2005-04-26" version="1">MGQKRSSSGDYPSPKRLQKQAADETDPIYEEAHSDVDYSPDDSSVTSSVHDTPATPFSTASTSVRYPSELKTHRCPFEGCTKAFNRPARLQEHLRSHNNERLFSCTYEGCQKTFLRASHLNHHVKSAHTGVRDYICDRPGCGKSFVTGSRLRRHLAAHDGRDKFRCTEYPPCNETFRKHSTLQKHVLSVHLKQKPFQCQHIDPQTGDKCLMAFESAGHLRAHESRVHTAKRFSCAECSQRVEDGSMIPPATFPTYSLLQAHIRTAHPPQCPTCSVTCSTARELRRHLEVAHGNVSLDDRRIFPCTVPGCDRSFTKKGNLTVHIRTVHDGEKRFVCGETDLSTSKRVTGWSAADGCGKRYGSKLALEEHIRTAHLGFLNSKAERRQKLGQPRKSSSINKNLSALTGEGYGDETGRQITCFVDSCPHRFHRNYDLWVHMGSKHNYTEDDIRGFFLQRALLGDSSEPVPSDVFGIYGLEFDNEEHTYNQDLRMGAYPPTPAETSGAGTGSYTAGQDQHQLPGMNIEPYTLEPTEFSMLPQSVPVSGCLDPDIMMQESASVSASKAQIPSLDNDDMLNDSFLDFGMVNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B9Z7</accession>
    <accession>C8VHH1</accession>
    <name>Q5B9Z7_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ANIA_02633</name>
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    <organism evidence="5 6">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF84316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_660237.1">
        <property type="nucleotide sequence ID" value="XM_655145.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B9Z7"/>
    <dbReference type="SMR" id="Q5B9Z7"/>
    <dbReference type="STRING" id="227321.Q5B9Z7"/>
    <dbReference type="GeneID" id="2874538"/>
    <dbReference type="KEGG" id="ani:ANIA_02633"/>
    <dbReference type="eggNOG" id="ENOG502SM8A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2171032_0_0_1"/>
    <dbReference type="InParanoid" id="Q5B9Z7"/>
    <dbReference type="OrthoDB" id="2139957at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBF84316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="110" mass="12386" checksum="22298AA803F24051" modified="2005-04-26" version="1">MVLPLPTYPTPTPEFACEKVRGRHSLRLSVYIGAVKGYLGWDIWGPYETHPELHILTAKDAPFAAIQRAGHGDLVQTPEERTYLAHLMGRPVGQKRMCVLGRETSIQEVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="111" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BAB9</accession>
    <accession>C8VPJ0</accession>
    <name>Q5BAB9_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Mitotic spindle checkpoint protein (Mad2), putative (AFU_orthologue AFUA_3G14340)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ANIA_02511</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MAD2 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF87000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_660115.1">
        <property type="nucleotide sequence ID" value="XM_655023.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BAB9"/>
    <dbReference type="FunCoup" id="Q5BAB9">
        <property type="interactions" value="1030"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5BAB9"/>
    <dbReference type="GeneID" id="2874687"/>
    <dbReference type="KEGG" id="ani:ANIA_02511"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN2511"/>
    <dbReference type="eggNOG" id="KOG3285">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072097_0_0_1"/>
    <dbReference type="InParanoid" id="Q5BAB9"/>
    <dbReference type="OMA" id="WQFDVEI"/>
    <dbReference type="OrthoDB" id="1806at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033597">
        <property type="term" value="C:mitotic checkpoint complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990498">
        <property type="term" value="C:mitotic spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010997">
        <property type="term" value="F:anaphase-promoting complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905318">
        <property type="term" value="P:meiosis I spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.900.10:FF:000002">
        <property type="entry name" value="Mitotic spindle assembly checkpoint protein MAD2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.900.10">
        <property type="entry name" value="HORMA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003511">
        <property type="entry name" value="HORMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036570">
        <property type="entry name" value="HORMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045091">
        <property type="entry name" value="Mad2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11842">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11842:SF11">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02301">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56019">
        <property type="entry name" value="The spindle assembly checkpoint protein mad2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50815">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HORMA" evidence="8">
        <location>
            <begin position="18"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="115"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBF87000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="225" mass="25496" checksum="67C3EF929ADDB2A8" modified="2005-04-26" version="1">MSTSKDKSKDKVHKLSIKGSSKLVAEFFEYSINSILFQRGVYPPEDFTTVKKYGLNMLVTADDQVKAYIKKIMSQLNKWMLGGKISKLVVVITDKETGEHVERWQFDVQIFGKQKSQSTRKSGDKENDTPGDVGQPETVEKTEKQIQEEIQAIFRQITASVTFLPVLDGDCTFNVLVYADADSDVPVEWGDSDAKDIKNPEKVQLRSFSTNNHRVETMVSYRLAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="101" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BAL1</accession>
    <accession>C8VNY0</accession>
    <name>Q5BAL1_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein transport protein SEC9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ANIA_02419</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNAP-25 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF86809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_660023.1">
        <property type="nucleotide sequence ID" value="XM_654931.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BAL1"/>
    <dbReference type="FunCoup" id="Q5BAL1">
        <property type="interactions" value="127"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5BAL1"/>
    <dbReference type="GeneID" id="2874847"/>
    <dbReference type="KEGG" id="ani:ANIA_02419"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN2419"/>
    <dbReference type="eggNOG" id="KOG3065">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020823_2_0_1"/>
    <dbReference type="InParanoid" id="Q5BAL1"/>
    <dbReference type="OMA" id="TNQRMER"/>
    <dbReference type="OrthoDB" id="18679at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd15857">
        <property type="entry name" value="SNARE_SEC9C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15886">
        <property type="entry name" value="SNARE_SEC9N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000043">
        <property type="entry name" value="Protein transport protein sec9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000048">
        <property type="entry name" value="Protein transport protein SEC9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19305">
        <property type="entry name" value="SYNAPTOSOMAL ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19305:SF9">
        <property type="entry name" value="SYNAPTOSOMAL-ASSOCIATED PROTEIN 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="6">
        <location>
            <begin position="366"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="103"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="132"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00072549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBF86809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="429" mass="46676" checksum="377FE8A94E251623" modified="2005-04-26" version="1">MKRFGLKKSSDAGDDDSSNRRALFGSRSKNKSPPAEANPYAKPIPADPYTRAKAQHGIAPPPPGVDLGGPPNHASGNAIPGDHKSQIPGDNKYQGYAPNAYGSQGGYGANRYGGGAGAAPTSRYGGYGGLGNADPNDPAAADDNRAALFGNASERAAAQPTTAPPPYSEGQPAQAGGYGASGNSYSAATYQERHLTAEEEEEQEVQAVKQDIRFMKQGDVASTRNALRIAAQAEETSRETLARLGAQGEMIHNTEKNLDVAGVEGRIADEKARELKTLNKSMFAVHVSNPFTSAQRKRDRDQRIMDNHRQVREAQAGTRSEAYKTNQRMEQTFREIEREDRKTNKPYKASVTERAKYQFEADSEDEAMEDEIEQNLNLIAGASGRLNLLAKATGRELDEQNRHLERIMGKSESVDDQLAMNRARLDRIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BAS7</accession>
    <accession>C8VNF7</accession>
    <name>Q5BAS7_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_02353</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
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    <accession>C8VN53</accession>
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        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
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    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
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            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
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            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
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        <property type="nucleotide sequence ID" value="XM_654817.1"/>
    </dbReference>
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        <property type="component" value="Chromosome VII"/>
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    <proteinExistence type="predicted"/>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="7"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
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            <begin position="114"/>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
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            <taxon>Eurotiomycetes</taxon>
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            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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    <reference evidence="23" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
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                <person name="Asai K."/>
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                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
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            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="23" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="23">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Catalytic tRNA acetyltransferase subunit of the elongator complex, which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). In the elongator complex, acts as a tRNA uridine(34) acetyltransferase by mediating formation of carboxymethyluridine in the wobble base at position 34 in tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>uridine(34) in tRNA + acetyl-CoA + S-adenosyl-L-methionine + H2O = 5-(carboxymethyl)uridine(34) in tRNA + 5'-deoxyadenosine + L-methionine + CoA + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:61020"/>
            <dbReference type="Rhea" id="RHEA-COMP:10407"/>
            <dbReference type="Rhea" id="RHEA-COMP:11727"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74882"/>
            <dbReference type="EC" id="2.3.1.311"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:61021"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17 18">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="17 18">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 17">Belongs to the ELP3 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="17"/>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF86551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_659898.1">
        <property type="nucleotide sequence ID" value="XM_654806.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BAY6"/>
    <dbReference type="FunCoup" id="Q5BAY6">
        <property type="interactions" value="986"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5BAY6"/>
    <dbReference type="GeneID" id="2875164"/>
    <dbReference type="KEGG" id="ani:ANIA_02294"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN2294"/>
    <dbReference type="eggNOG" id="KOG2535">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025983_2_1_1"/>
    <dbReference type="InParanoid" id="Q5BAY6"/>
    <dbReference type="OMA" id="TFETRPD"/>
    <dbReference type="OrthoDB" id="10265243at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106261">
        <property type="term" value="F:tRNA uridine(34) acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140018">
        <property type="term" value="P:regulation of cytoplasmic translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002926">
        <property type="term" value="P:tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000003">
        <property type="entry name" value="Elongator complex protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039661">
        <property type="entry name" value="ELP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034687">
        <property type="entry name" value="ELP3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056591">
        <property type="entry name" value="ELP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032432">
        <property type="entry name" value="Radical_SAM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01211">
        <property type="entry name" value="ELP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11135:SF0">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11135">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23613">
        <property type="entry name" value="ELP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16199">
        <property type="entry name" value="Radical_SAM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005669">
        <property type="entry name" value="Hist_AcTrfase_ELP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01086">
        <property type="entry name" value="elongater_protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00344">
        <property type="entry name" value="ELP3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="15 17" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="12 18" id="KW-0408">Iron</keyword>
    <keyword evidence="13 17 18" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9 17 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 17" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="8 17" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="5 17" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Radical SAM core" evidence="21">
        <location>
            <begin position="100"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="20">
        <location>
            <begin position="414"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRNR" id="PIRNR005669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR005669-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="CBF86551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="574" mass="64758" checksum="7F88D7E740E001A9" modified="2005-04-26" version="1">MATTTMTAPPPIKTKNSKLPPENERFMRACSDIANALIQEYESQKDPTQPKRDINLNKLRGQMAKKHSLSHQPPLTAIISAVPEHYKKYILPKLIAKPIRTSSGIAVVAVMSKPHRCPHIAYTGNICVYCPGGPDSDFEYSTQSYTGYEPTSMRAIRARYDPFEQARGRVEQIRSLGHSVDKVEYIIMGGTFMSLPAEYRDTFVAQLHNALSGYQTDNVDEAVQAGEMSNIKCVGITIETRPDYCLDTHLSSMLRYGCTRLEIGVQSLYEDVARDTNRGHTVAAVAETFKLAKDAGFKVVSHMMPDLPNVGMERDLFQFEEYFENPAFRTDGLKIYPTLVIRGTGLYELWRTGRYKNYTPNALIDLVARILALVPPWTRIYRVQRDIPMPLVTSGVENGNLRELALARMKDFGTTCRDVRTREVGINEVKNKIRPSQVELIRRDYTANGGWETFLAYEDPKQDILIGLLRLRKCSPTHTFRPEFTGQQTSIIRELHVYGSAVPLHGRDPRKFQHLGFGTLLMEEAERIAREEHGSTKISVISGVGVRSYYARLGYSLDGPYMSKMLEPIEGGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="125" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BB30</accession>
    <accession>C8VMU6</accession>
    <name>Q5BB30_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ANIA_02250</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF86465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_659854.1">
        <property type="nucleotide sequence ID" value="XM_654762.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BB30"/>
    <dbReference type="STRING" id="227321.Q5BB30"/>
    <dbReference type="GeneID" id="2875330"/>
    <dbReference type="KEGG" id="ani:ANIA_02250"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN2250"/>
    <dbReference type="eggNOG" id="KOG1205">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_2_9_1"/>
    <dbReference type="InParanoid" id="Q5BB30"/>
    <dbReference type="OMA" id="MTRHEER"/>
    <dbReference type="OrthoDB" id="1274115at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051911">
        <property type="entry name" value="SDR_oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976:SF16">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010164937" evidence="4">
        <location>
            <begin position="19"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBF86465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="289" mass="31166" checksum="F03CCBC1DF3ED695" modified="2005-04-26" version="1">MAASFMTWLITGASSGLGKSLALAALKAGHKVVATTRDVGRAEKSCPDFSTQGGIWVELDPAQEDAYYLFTKFAQEHYVDVLVNNAGYAFIGGVEDTSLSDDAHMCAVRPTSEIRWKSTFMALCELSEPACRFCGPEALATSSLLAVAQGRGTYSASKFAIEAMHESLSYEVKELGIKVLIVEPGAFRTPFASRVLTPTQFEHGFSEGYKDTVLQQMMTAHRSIKSIPDQFKGDPDKAARAILSAIASGYEYLRLPLGTDCVAALEDKIGQLQRDLAATRAIATATDVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="119" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BB36</accession>
    <accession>C8VMT7</accession>
    <name>Q5BB36_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GTP binding protein (Gtp1), putative (AFU_orthologue AFUA_5G06770)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ANIA_02244</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF86451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_659848.1">
        <property type="nucleotide sequence ID" value="XM_654756.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BB36"/>
    <dbReference type="FunCoup" id="Q5BB36">
        <property type="interactions" value="1046"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5BB36"/>
    <dbReference type="GeneID" id="2875486"/>
    <dbReference type="KEGG" id="ani:ANIA_02244"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN2244"/>
    <dbReference type="eggNOG" id="KOG1486">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044997_0_0_1"/>
    <dbReference type="InParanoid" id="Q5BB36"/>
    <dbReference type="OMA" id="DVCDQVH"/>
    <dbReference type="OrthoDB" id="603at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903833">
        <property type="term" value="P:positive regulation of cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01896">
        <property type="entry name" value="DRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000003">
        <property type="entry name" value="Developmentally-regulated GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000740">
        <property type="entry name" value="Putative GTP-binding protein 1"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Beta-grasp_dom_sf"/>
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    <dbReference type="InterPro" id="IPR045001">
        <property type="entry name" value="DRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031662">
        <property type="entry name" value="GTP-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006074">
        <property type="entry name" value="GTP1-OBG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43127">
        <property type="entry name" value="DEVELOPMENTALLY-REGULATED GTP-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16897">
        <property type="entry name" value="MMR_HSR1_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00905">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="3">
        <location>
            <begin position="64"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="4">
        <location>
            <begin position="291"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBF86451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="367" mass="40801" checksum="9831A715E41B9B0C" modified="2005-04-26" version="1">MVNITEKIKEIEDEMRRTQKNKATEYHLGLLKGKLARLRAQLLEPTGGSGGGGAGFDVSKSGDARVALVGFPSVGKSTFLSKITKTKSEAAAYSFTTLTAIPGVLEYGGAEIQILDLPGIIEGASEGKGRGRQVISAAKTSDLILMVLDATKKAEQRALLEAELDAVGIRLNKEPPNIYLKAKKAGGMKITFQTPPKYLDEKMIYNVLRDYKMLNCEVLVRDENATIDDFIDVIMKDHRKYIPCLYVYNKIDSVSIEFLDQLAREPHTAVMSCELDLAVQDVVERIWKELRLMRIYTKRKGVEPDFSEALIVRNNSTIEDVCDQIHRTLKETFKYALVWGASARHIPQRVGLSHVVADEDVVSIVAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="100" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BBG2</accession>
    <accession>C8VLZ9</accession>
    <name>Q5BBG2_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Amidohydrolase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ANIA_02118</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF86213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_659722.1">
        <property type="nucleotide sequence ID" value="XM_654630.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BBG2"/>
    <dbReference type="STRING" id="227321.Q5BBG2"/>
    <dbReference type="GeneID" id="2875772"/>
    <dbReference type="KEGG" id="ani:ANIA_02118"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN2118"/>
    <dbReference type="eggNOG" id="KOG4245">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039329_5_1_1"/>
    <dbReference type="InParanoid" id="Q5BBG2"/>
    <dbReference type="OMA" id="FWPVFEK"/>
    <dbReference type="OrthoDB" id="432010at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000099">
        <property type="entry name" value="Amidohydrolase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="2-AMINO-3-CARBOXYLMUCONATE-6-SEMIALDEHYDE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240:SF30">
        <property type="entry name" value="AMIDOHYDROLASE-RELATED DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="4">
        <location>
            <begin position="55"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU366045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBF86213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="337" mass="38069" checksum="8E9F8291BEA109CB" modified="2005-04-26" version="1">MPPHSITKLIARPIIALEEHFLSRAALASPNALNERMRAIPGLFDNFTELGPRRIADMDHGQVTMQVISHGPGDLSPAQCRETNNQLAEAIRACPTRFAGFAELPMHEPQEAAMELRRMCSGALDGIRFVGALVDSHTEGGLYYDGPEFDVLWDEATKLDVPIYIHPTWPSQQLFTAYRSSNIPEDVNTAILSFGFGWHGDVAIHILRLYAAGVFDRFPKLKIIIGHMGEMVPYMLQRIERVSSRWGKERSFREVWDQNLWLTTSGNWALDPLACILRNTKHDRIMYSVDYPFAKSADGLKWLEELEESGMVTEEVLEGIRWRNAAQLLKLNALPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BBJ2</accession>
    <accession>C8VLR6</accession>
    <name>Q5BBJ2_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ANIA_02088</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CENP-K/MCM22 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF86153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_659692.1">
        <property type="nucleotide sequence ID" value="XM_654600.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BBJ2"/>
    <dbReference type="GeneID" id="2875729"/>
    <dbReference type="KEGG" id="ani:ANIA_02088"/>
    <dbReference type="eggNOG" id="ENOG502RXW1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048926_0_0_1"/>
    <dbReference type="InParanoid" id="Q5BBJ2"/>
    <dbReference type="OMA" id="IAQFHPK"/>
    <dbReference type="OrthoDB" id="9445768at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051382">
        <property type="term" value="P:kinetochore assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020993">
        <property type="entry name" value="Centromere_CenpK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14401">
        <property type="entry name" value="CENTROMERE PROTEIN K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14401:SF6">
        <property type="entry name" value="CENTROMERE PROTEIN K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0137">Centromere</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="250"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="34"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="261"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="282"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBF86153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="313" mass="35305" checksum="C6DA3902FE8DD2FF" modified="2005-04-26" version="1">MFSDRKMEIPQERIEKVLSFAEDRRKAENFYDENRASSSEIQTYERKLDNTLRELQERVKQQEEDLRKLRAANANGISEIGTDPSSRIAQIRRATKAYNSLLKSESNLPTPESPLPSLIALEETSRIIDESKVSVLATAENLASVRQRLKTEEKNLHDAQAISDGLRRRIDNIRKDKSASHEKLPSEVARECLEERRRKKDDLDKDTVRIRAALHSFCDETLASLVAAEDLGGPAVGDVAEVSEATLAAGYTRHGKPKKPKAAEEDNHDNSQHRIDDMLRRQTGQQSNQPSSRKEVAATEIHELLDALLEAGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="119" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BBK5</accession>
    <accession>C8VLQ2</accession>
    <name>Q5BBK5_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ANIA_02075</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PheA/TfdB FAD monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF86128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_659679.1">
        <property type="nucleotide sequence ID" value="XM_654587.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BBK5"/>
    <dbReference type="GeneID" id="2874918"/>
    <dbReference type="KEGG" id="ani:ANIA_02075"/>
    <dbReference type="eggNOG" id="KOG3855">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009665_9_4_1"/>
    <dbReference type="InParanoid" id="Q5BBK5"/>
    <dbReference type="OMA" id="VDWWTIY"/>
    <dbReference type="OrthoDB" id="2096480at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038220">
        <property type="entry name" value="PHOX_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050641">
        <property type="entry name" value="RIFMO-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004:SF5">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004">
        <property type="entry name" value="TRK SYSTEM POTASSIUM UPTAKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="14"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBF86128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="593" mass="65145" checksum="06AEFE5B40D84923" modified="2005-04-26" version="1">MTTSDPTVTGETTYDVVIVGGGPVGLLLAYQLKKFGISVCVLEQHKKETQDAYGRAIALFPRTLEQLDQLGAVEPMLQLGFACRNSVTYKNGERIIPGRVWTFMENIKDTTFDFTLVLRQMYTEEILREKLKSVGVSYYQGMECVGFDCDPNKAPDGFPMTSTYQNAVTGETFYLKRKSTSLSHDSKYLIGADGGRSFVRRHAGIPFEGDISEDRWIRIDGIVETDMPITRAYGAIESETHGNVLWAPLDHGAIRIGYAYSAEIAAKYPNGVTQEVAVQEAIEAMKPFKVSFREVHWWTLYTIGQRIAKTFATANNHVFLCGDAAHTHSSGAAQGLNTGIHDAVNLGWKLALHIRGLTKPEVLETYTAERLTTVQRLIDYDKDIATLMSSKWPAWYTGDPNADPHLVLGQIFDEAAAFNTGLGISYPANVLNDLGSVSYTNNSSQCVLAPGSRPPDVDLKMPATNQLVRLQKITPNNAQFWVIIFAGNNSPSIQETLGALQRYLRDTAPELISHKSIRWLTITTAVGCSPYEALGMDPLGDAYFDAAKPLAHGRLGVDMEEGAAVILRPDGLVGATASAYGEGHTQYPWLAIL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2020-10-07" modified="2026-01-28" version="143" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BBP8</accession>
    <accession>C8VLG0</accession>
    <name>PKHA_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Non-reducing polyketide synthase pkhA</fullName>
            <shortName evidence="8">NR-PKS pkhA</shortName>
            <ecNumber evidence="7">2.3.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Pkh biosynthesis cluster protein B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">pkhA</name>
        <name type="ORF">ANIA_02032</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2012" name="J. Am. Chem. Soc." volume="134" first="8212" last="8221">
            <title>Illuminating the diversity of aromatic polyketide synthases in Aspergillus nidulans.</title>
            <authorList>
                <person name="Ahuja M."/>
                <person name="Chiang Y.M."/>
                <person name="Chang S.L."/>
                <person name="Praseuth M.B."/>
                <person name="Entwistle R."/>
                <person name="Sanchez J.F."/>
                <person name="Lo H.C."/>
                <person name="Yeh H.H."/>
                <person name="Oakley B.R."/>
                <person name="Wang C.C."/>
            </authorList>
            <dbReference type="PubMed" id="22510154"/>
            <dbReference type="DOI" id="10.1021/ja3016395"/>
        </citation>
        <scope>DOMAIN</scope>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>PATHWAY</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Highly reducing polyketide synthase; part of the pkh gene cluster that mediates the biosynthesis of 2,4-dihydroxy-6-[(3E,5E,7E)-2-oxonona-3,5,7-trienyl]benzaldehyde (PubMed:22510154). The highly reducing polyketide synthase pkhB first produces the (2E,4E,6E)-octa-2,4,6-trienyl strater unit for the non-reducing polyketide synthase pkhA (PubMed:22510154). This octatrienoyl starter is then loaded onto the SAT domain of the NR-PKS pkhA to be condensed with 4 malonyl-CoA units to yield 2,4-dihydroxy-6-[(3E,5E,7E)-2-oxonona-3,5,7-trienyl]benzaldehyde (PubMed:22510154).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(2E,4E,6E)-octa-2,4,6-trienyl-[ACP] + 4 malonyl-CoA + AH2 + 3 H(+) = 2,4-dihydroxy-6-[(3E,5E,7E)-2-oxonona-3,5,7-trienyl]benzaldehyde + holo-[ACP] + A + 4 CO2 + 4 CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:64524"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:16617"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:155862"/>
            <dbReference type="ChEBI" id="CHEBI:155872"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:64525"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
        <text evidence="2">Binds 1 phosphopantetheine covalently.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="domain">
        <text evidence="9">Multidomain protein; including an N-terminal starter unit:ACP transacylase (SAT) domain, a beta-ketoacyl synthase (KS) domain, a malonyl-CoA:ACP transacylase (MAT) domain, a product template (PT) domain that controls the immediate cyclization regioselectivity of the reactive polyketide backbone, an acyl carrier protein (ACP) domain, and a reductive NADPH-binding domain that is required for NADPH-dependent product release.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="7"/>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF86046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_659636.1">
        <property type="nucleotide sequence ID" value="XM_654544.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BBP8"/>
    <dbReference type="SMR" id="Q5BBP8"/>
    <dbReference type="EnsemblFungi" id="CBF86046">
        <property type="protein sequence ID" value="CBF86046"/>
        <property type="gene ID" value="ANIA_02032"/>
    </dbReference>
    <dbReference type="GeneID" id="2875205"/>
    <dbReference type="KEGG" id="ani:ANIA_02032"/>
    <dbReference type="eggNOG" id="KOG1178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1202">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_6_2_1"/>
    <dbReference type="InParanoid" id="Q5BBP8"/>
    <dbReference type="OMA" id="FERMACG"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032088">
        <property type="entry name" value="SAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF14">
        <property type="entry name" value="ITERATIVE POLYKETIDE SYNTHASE AFOE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16073">
        <property type="entry name" value="SAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0012">Acyltransferase</keyword>
    <keyword id="KW-0511">Multifunctional enzyme</keyword>
    <keyword id="KW-0521">NADP</keyword>
    <keyword id="KW-0596">Phosphopantetheine</keyword>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000450876" description="Non-reducing polyketide synthase pkhA">
        <location>
            <begin position="1"/>
            <end position="2221"/>
        </location>
    </feature>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="4 9">
        <location>
            <begin position="403"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="5">
        <location>
            <begin position="1294"/>
            <end position="1608"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="3">
        <location>
            <begin position="1666"/>
            <end position="1743"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal acylcarrier protein transacylase domain (SAT)" evidence="2 9">
        <location>
            <begin position="104"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Malonyl-CoA:ACP transacylase (MAT)" evidence="2 9">
        <location>
            <begin position="905"/>
            <end position="1197"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="5">
        <location>
            <begin position="1294"/>
            <end position="1424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Product template (PT) domain" evidence="9">
        <location>
            <begin position="1298"/>
            <end position="1612"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="5">
        <location>
            <begin position="1456"/>
            <end position="1608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1632"/>
            <end position="1665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1745"/>
            <end position="1796"/>
        </location>
    </feature>
    <feature type="region of interest" description="NADPH-binding domain" evidence="2 9">
        <location>
            <begin position="1850"/>
            <end position="2093"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1880"/>
            <end position="1899"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1655"/>
            <end position="1665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1880"/>
            <end position="1894"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; for transacylase activity" evidence="1">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor; for transacylase activity" evidence="1">
        <location>
            <position position="268"/>
        </location>
    </feature>
    <feature type="active site" description="For beta-ketoacyl synthase activity" evidence="4">
        <location>
            <position position="576"/>
        </location>
    </feature>
    <feature type="active site" description="For beta-ketoacyl synthase activity" evidence="4">
        <location>
            <position position="711"/>
        </location>
    </feature>
    <feature type="active site" description="For beta-ketoacyl synthase activity" evidence="4">
        <location>
            <position position="750"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="5">
        <location>
            <position position="1327"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="5">
        <location>
            <position position="1512"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="3">
        <location>
            <position position="1703"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="A0A0K0MCJ4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="7">
        <source>
            <dbReference type="PubMed" id="22510154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="8">
        <source>
            <dbReference type="PubMed" id="22510154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="9">
        <source>
            <dbReference type="PubMed" id="22510154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBF86046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="2221" mass="241564" checksum="22F86FC84EFAF3D2" modified="2005-04-26" version="1">MKPSSNICQATSFIFGGHIGPQTKNSLEKEIREVANGPNGGWILDTLAGMPRYWEAVTEKIPEVASTMQGVQLLSDLESWFRIGSDSVDSLAPDAELPDLWLGILMVIIQLDQYWRYLESRFADRAVDDLQGELIKEEKVEAVGFCAGMIAAVAIASSHTRQEFKKYGAVALRIAALMAILVGATEEWTKAMGKGRSVSFATAWRTRKQGDDMARIISKLSPDAYISVILDDSRATVTVSERLAPKLVRQLRAAGVTAIQLAFKGQLHSPTAERKRLTEAVVELCQSMPELRYPVAARLALPINQVSGQETDLVGMVLRSMLVNQLNWTSTTSMLTLNKEELSRVEFGLDRPLPPPVVRAFGAMLDYKEVDVPKHRQYDKGKEPVHDTESVQVAEPPLQEADENVIAVVGMSIKVAGANDLEEFQQMLKTGHSQHQLVTNDHITPNMMFRNKVPNRKWYGNFVRDPDAFDHKFFKKSPRESMAIDPQGRLSLEAAYQALEQSGYFNELTMTSAAEQERKKHVGVYVGVCSYEYDSNVHCHPPSAFTTTGELRSFIPGRISHYFGWTGPSLTFDTACSSSTVALHNACRDLLSGEVPAALCGGVNILTSLQWTQNLAAGSFISPTGQCKPFDSGADGYCRGDGIAYVFLKKLSNAVADGNTVLGTICSTGVNQNLNTTPLFVPNVPSLSTLFNEVIRKARIARRDISLVECHGTGTPVGDPAEWQSIRNAVAGPRRDTVLPIGSVKGHVGHTEGASGLVSLIKVLMMMRGNFIPPQASFNTMSPGIHAQPSDNMEVVTALRSWPGAQKVALINNYGACGSNSSAIVAHSAHKPVKGPLSGGQRLPFWISGLDARSIAAYSTALASYLHSQDQAASLADAKLALAAKATKDTAPSVGIVPVKPERPVILCFGGQVSTFIGLDRAVYEGASVFRHHLDTCNAAITSHSLESIYPDIFSSEPYQDTIKLQTALFAMQYASAKTWMDCGIAEKVVSVVGHSFGEITALCVSGVLSLEDSVKLIAGRAKLVQTAWGADSGSMMAIEADGAVVQDLLQESNARSDGTAGIACYNGPRSFTVAGSTKAIDAFAATLPGKEVKSKRLNVTNAFHSALVESIVDRLGEVGKEVTFHDAVIPIERATEHSGDATLDWTFVGSHMRRPVFFNHAVQRLAEKYPDAIFLEAGSNSTITVMASRALANPKSTHHFQSISITNTNKGIARLTDATVDLWKQGLRVSFWAHHRFQKDEYAQLLLPPYQFEKTRHWLELKSPIEQAMNIAKVQDGIAAQKGHVNNKSLEIWTFLGFQKQKKKTKLARFRINTSSDKYQRLFATHVIAKTAPIAPATLEIDMAIETLFSLNPEWRQSGFSPVIRDMLSHSPMCADSTREYFLDLVPLNPTETEWQWTIQSTGTSSANDKHAEGRIAMYSSSDPAALQEFGRWERIVTYAQCQAVLALGSQDEGVEALQGRNVYRAFEEVVDFGSVYRGVKYIVGQEKGESAGIVHKQHSGDTWLDVPKADCYGQIAGMYVNLLTDIPSSDMFVATGLELVMRSPKAQTVTDGRENGPNVWHVLARHARQGEKAYVTDVFVFDASTGALAEVILGLQYVRVPKATMSKILARMTTDKSFVRSTATASLLLPDRPQPHDGPITATVPRPAPPKATKTNVAKTEPVSSARNIAKEVCNVVANVSGIEASELSLDSEMADLGIDSLMAMEVAREMENTFHCTLDSTETMVATNIRDFAACVSNALARSGGQDGASTSTESDAMLSDSEDEDTDSGISTPDDASEITSKSHDPVSEPLTSTILNVDHGDVAARNAEALRLVEAYTAGWDSRAVKDANNRIITTGSGDGAVVIVTGASGSLGSHLVQALAERPDVSGVVCINRPVKDTPPDSRQEEALSSRSIKLSPAAREKLQVYGTDTSKAQLGLSKKEYNWLAQHGTHIIHNAWPMSATRPLKAFEPQLQVMRNMLDLARDMALGDEPRRIGFQFVSSIGVTGLSNESPVLEQPVAFAATIPGGYNEAKWTCERMLTDTLRRHPQLFQAMVARPGQISGSTASGFWNPVEHFPFVVKSAHALKVFPDLQGVLHWLPVDKAASIMVDLLSISGSKGSGEVYPVYHVDNPVGQLWKEMVTVLAASLDIPPHGIVPFREWIQRVRQSSLPPAQNPASMGLGFLESHFERMACGGIVLDTQHSREHSETMAAQGPVSAEVVRSYVSSWKAMGLLRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BBV2</accession>
    <accession>C8VL52</accession>
    <name>Q5BBV2_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ANIA_01978</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF85936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_659582.1">
        <property type="nucleotide sequence ID" value="XM_654490.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BBV2"/>
    <dbReference type="GeneID" id="2875283"/>
    <dbReference type="KEGG" id="ani:ANIA_01978"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN1978"/>
    <dbReference type="HOGENOM" id="CLU_1686543_0_0_1"/>
    <dbReference type="InParanoid" id="Q5BBV2"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF85936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="156" mass="17032" checksum="39FBD5212BB8FBE8" modified="2005-04-26" version="1">MWKLGDFALSRDDSSSHPVLSGGQRGYSVSRAQVRLPGSFSKVVKAREPTPHLSRTSPGLNFSVSEDGGSSLNTCTSVILGIPVKLIDVRIPRADRVAYYVLANCIRRHQIRAQESMSVQHPTLPVSDEIIGIIPDTKALIEIQSLELETIIIGQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BC22</accession>
    <accession>C8VKS8</accession>
    <name>Q5BC22_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ataxin-10 homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Copper transport protein 86</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ANIA_01908</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May play a role in the regulation of cytokinesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ataxin-10 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF85803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_659512.1">
        <property type="nucleotide sequence ID" value="XM_654420.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BC22"/>
    <dbReference type="STRING" id="227321.Q5BC22"/>
    <dbReference type="GeneID" id="2874924"/>
    <dbReference type="KEGG" id="ani:ANIA_01908"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN1908"/>
    <dbReference type="eggNOG" id="KOG2676">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005559_2_0_1"/>
    <dbReference type="InParanoid" id="Q5BC22"/>
    <dbReference type="OMA" id="FIMHNEH"/>
    <dbReference type="OrthoDB" id="379794at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051374">
        <property type="entry name" value="Ataxin-10/CTR86_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019156">
        <property type="entry name" value="Ataxin-10_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13255">
        <property type="entry name" value="ATAXIN-10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13255:SF0">
        <property type="entry name" value="ATAXIN-10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09759">
        <property type="entry name" value="Atx10homo_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ataxin-10" evidence="8">
        <location>
            <begin position="805"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="401"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="433"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="744"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="408"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="467"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="744"/>
            <end position="761"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00044801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF09759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBF85803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="911" mass="101946" checksum="2A4110F86DE7F3FD" modified="2005-04-26" version="1">MAERASAEMKPKCTPAELMLKVILMGTLSHYETRGMIDDKRLDHMLSAGKQILYKTHQESDVRHGLGLSPDIWQGLTDVFTKAIPVLESQSFIWKSPPAANYEHSSSNLIAYNYFSLVKDIERLNDLCTIARNLLATTKKAQNMAAEKGFDQRVLALVDTCVRVTARGFDGETNARNEERWQKVVNLYKRLLITCLQFLHNFIMHNEQRKMVLWLDLFGYHSTGDSNIIQPKEPLDQASSQPEGLAPIVKTGERIVNPPIRALYDQTAEDLLLETISNFPREPATIKEEAAMLLLANIKDHMEKLLGRDLTAIQEMGKDPDQVKEIRAALTAILGAKVDGWSDLQDRAKDLPPALPDDEPPRKKAILTIDRSPTAGFPRICWSDLPDLNEYGVVAAGDAPIAEEDTTMPRSSQSAAETLQEAKDELMARLQEASQMGDERDHDYDAGDAGTVGDDDSRSLEAVADGSIDEEEEEDDEDDDDYRGRPGDQQRGLLTDIPLVLGPAEIEALPMIIQAGIVDSFGLKGGERTGSRNMQALRCHILLTQETGRNLLRELLIFIAAWDLPDDELYFKMMVQIMDAVLRNGLMSHAYSDFGQPKDIISPAQAVVVKILTHIFRAKYSPASVTGSGQANATKNPAPLSRVDVLTVRYIFTIFRGNIIPETCALIYLQGQIRAGRALPEDFPLNLWDMERVYEGVYQFLEFFAVLTENNDWKNLLVKWEIVYDLVTLIKELEASIPKGQLSQLNLGRNSPSREQQQSASPGPIAVERPYDPSDPDPTDGGTASRPESPPITEDPSEFEWRNLKKLVVLVLSSLVWKCPEVQDQIRRYGGVETILSCTNFDAHNPYIKEHAVMCLKFLLEGNRENQKLIEELEAREVRDDNGMLQQRGLEAVIDKTGKLAIRPRDGQSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BCL1</accession>
    <accession>C8VP18</accession>
    <name>Q5BCL1_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">WSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ANIA_01719</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF85429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_659323.1">
        <property type="nucleotide sequence ID" value="XM_654231.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BCL1"/>
    <dbReference type="GeneID" id="2875541"/>
    <dbReference type="KEGG" id="ani:ANIA_01719"/>
    <dbReference type="eggNOG" id="ENOG502SSVT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051536_1_0_1"/>
    <dbReference type="InParanoid" id="Q5BCL1"/>
    <dbReference type="OMA" id="DVNWGLY"/>
    <dbReference type="OrthoDB" id="5426678at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010201198" description="WSC domain-containing protein" evidence="3">
        <location>
            <begin position="26"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="232"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="347"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="357"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBF85429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="383" mass="42270" checksum="8D3072A489808828" modified="2005-04-26" version="1">MGPSGFSKRTISRWTVFGLLRLASALRTTPGSPCESACSPANATLPSEIVCFDSEYNNTEAGRKFEGCIACQLQSTFVDDASRQSDVEWGLFILTGTVNLRFAFSSCVYGYPEKVTNSSNSCPVACKDIESSVEYQLDSPSGENIETWCDTASFADNEITDCNACYNLTSDEVRPQVYLANFLESLRYNCHFETPTEEEFPITPSRIFSESLLPSSSADLISGDGDGDNSNLALIIAMPILGFVILLCILALGCFFFIRSRRKKARRLRQPAHLHARWNDTGISTPQWAMEYPAQAQGMYGPTVYSPQPHHGYAQSPGFGFGFIDKDGRSQEVGYSKVVEPVIASPSTAYSPEEKVPQAQVQPYQQQTYFQQTPPNNGKGRQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BCT7</accession>
    <accession>C8VNI9</accession>
    <name>Q5BCT7_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Lignostilbene dioxygenase, putative (AFU_orthologue AFUA_4G01500)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ANIA_01643</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="5">Binds 1 Fe(2+) ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the carotenoid oxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF85281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_659247.1">
        <property type="nucleotide sequence ID" value="XM_654155.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BCT7"/>
    <dbReference type="SMR" id="Q5BCT7"/>
    <dbReference type="GeneID" id="2875358"/>
    <dbReference type="KEGG" id="ani:ANIA_01643"/>
    <dbReference type="eggNOG" id="KOG1285">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016472_6_2_1"/>
    <dbReference type="InParanoid" id="Q5BCT7"/>
    <dbReference type="OMA" id="ASYRNRW"/>
    <dbReference type="OrthoDB" id="1069523at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010436">
        <property type="term" value="F:carotenoid dioxygenase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016121">
        <property type="term" value="P:carotene catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004294">
        <property type="entry name" value="Carotenoid_Oase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10543">
        <property type="entry name" value="BETA-CAROTENE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10543:SF89">
        <property type="entry name" value="CAROTENOID 9,10(9',10')-CLEAVAGE DIOXYGENASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03055">
        <property type="entry name" value="RPE65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="462"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR604294-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBF85281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="480" mass="54510" checksum="62811254005CC2D4" modified="2005-04-26" version="1">MSGFEAHFSDRPQFSGFMKPCRFEGDVSHLEVYGEIPKDIDGVFYRVMPDPQLPPFIEDDPRYVQTEKFVREREAQRALLAGLGKYRNRFTDAVELKVRSTANTNVVFFNGQLLALKEDSPPYALDPVTLDTKGLYDFEGQLPSLTFTAHPKFDPATGEMVCFGYEARGDGTPDVCYYSVSPTGKFTEVVWLVAPVVAMIHDFAVTDNWVIFPIIPQVCDLERMKQGGEHWQWSPETPFYLGVMPRRGAKAEEVKWFRYMNSFPGHTANAYENEQGHLVIDLGLSEKNVFFWWPDAQGNAPEPSSIVSQLVRFTIDPQTEDLTLREPEVLQEGNSEFYRIDDRFATRPYRHCYFDLMDPQLGTDFERIGTKIGGGFPLYNSLAHLDHTTGQVEVYFPGRTHLVQEPVFIPRKNSSTEGDGHVLALVNNYDTMASELHLLDTRDFARAQAKILLPVRLRQGLHGSWVDASDDDHRVSTVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="106" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BDL0</accession>
    <accession>C8VRV9</accession>
    <name>Q5BDL0_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mob1/phocein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_01370</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF87632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_658974.1">
        <property type="nucleotide sequence ID" value="XM_653882.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BDL0"/>
    <dbReference type="STRING" id="227321.Q5BDL0"/>
    <dbReference type="GeneID" id="2877146"/>
    <dbReference type="KEGG" id="ani:ANIA_01370"/>
    <dbReference type="eggNOG" id="KOG0440">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038321_0_0_1"/>
    <dbReference type="InParanoid" id="Q5BDL0"/>
    <dbReference type="OMA" id="VSYAHNP"/>
    <dbReference type="OrthoDB" id="10261121at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030295">
        <property type="term" value="F:protein kinase activator activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.30">
        <property type="entry name" value="MOB kinase activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005301">
        <property type="entry name" value="MOB_kinase_act_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036703">
        <property type="entry name" value="MOB_kinase_act_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22599">
        <property type="entry name" value="MPS ONE BINDER KINASE ACTIVATOR-LIKE MOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03637">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01388">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101152">
        <property type="entry name" value="Mob1/phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR605301-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF87632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="290" mass="32348" checksum="E132722964D5D2ED" modified="2005-04-26" version="1">MNNGSPGQSPAPQSPHGHVPNAQSFASNHSAIETTAVYDPDAPKYFFQEKYAPLNVKGNFLTLCACPKNVELGEWLAHQIVEQNRLLQAMLKVIQEVNSHTGLPICNETSCPTMSAGRLTYTWLVDSQAAKISAPKFINRVEKWIVSKIHDPVMFPTEKVTGVPDTFALSEATGASAADAAANAGGEDWIGKSSGFPRTFYKDCQGIMKQMFRCYAHLYHAHWLNPFWHINKHDILNMCFVHFVTVAKYYKLVSDKEMEPMQPLIDLFIKQQRIPPEALNGGHWGQQSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="123" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BEN1</accession>
    <accession>C8VU67</accession>
    <name>Q5BEN1_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Adenylyl cyclase-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ANIA_00999</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">The N-terminal domain binds to adenylyl cyclase, thereby enabling adenylyl cyclase to be activated by upstream regulatory signals, such as Ras. The C-terminal domain is required for normal cellular morphology and growth control.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the CAP family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF88364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_658603.1">
        <property type="nucleotide sequence ID" value="XM_653511.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BEN1"/>
    <dbReference type="FunCoup" id="Q5BEN1">
        <property type="interactions" value="731"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5BEN1"/>
    <dbReference type="GeneID" id="2876770"/>
    <dbReference type="KEGG" id="ani:ANIA_00999"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN0999"/>
    <dbReference type="eggNOG" id="KOG2675">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015780_1_0_1"/>
    <dbReference type="InParanoid" id="Q5BEN1"/>
    <dbReference type="OMA" id="KSQQTHK"/>
    <dbReference type="OrthoDB" id="77251at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000935">
        <property type="term" value="C:division septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035838">
        <property type="term" value="C:growing cell tip"/>
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    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008179">
        <property type="term" value="F:adenylate cyclase binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030042">
        <property type="term" value="P:actin filament depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051014">
        <property type="term" value="P:actin filament severing"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010619">
        <property type="term" value="P:adenylate cyclase-activating glucose-activated G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019933">
        <property type="term" value="P:cAMP-mediated signaling"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030308">
        <property type="term" value="P:negative regulation of cell growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031138">
        <property type="term" value="P:negative regulation of conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030836">
        <property type="term" value="P:positive regulation of actin filament depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090141">
        <property type="term" value="P:positive regulation of mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046579">
        <property type="term" value="P:positive regulation of Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.330:FF:000001">
        <property type="entry name" value="Adenylyl cyclase-associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.70:FF:000008">
        <property type="entry name" value="Adenylyl cyclase-associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.330">
        <property type="entry name" value="Adenylate cyclase-associated CAP, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001837">
        <property type="entry name" value="Adenylate_cyclase-assoc_CAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013912">
        <property type="entry name" value="Adenylate_cyclase-assoc_CAP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013992">
        <property type="entry name" value="Adenylate_cyclase-assoc_CAP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017901">
        <property type="entry name" value="C-CAP_CF_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016098">
        <property type="entry name" value="CAP/MinC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036223">
        <property type="entry name" value="CAP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018106">
        <property type="entry name" value="CAP_CS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053950">
        <property type="entry name" value="CAP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036222">
        <property type="entry name" value="CAP_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006599">
        <property type="entry name" value="CARP_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10652">
        <property type="entry name" value="ADENYLYL CYCLASE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10652:SF0">
        <property type="entry name" value="ADENYLYL CYCLASE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08603">
        <property type="entry name" value="CAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21938">
        <property type="entry name" value="CAP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01213">
        <property type="entry name" value="CAP_N-CM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00673">
        <property type="entry name" value="CARP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69340">
        <property type="entry name" value="C-terminal domain of adenylylcyclase associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101278">
        <property type="entry name" value="N-terminal domain of adenylylcyclase associated protein, CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51329">
        <property type="entry name" value="C_CAP_COFACTOR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01088">
        <property type="entry name" value="CAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-CAP/cofactor C-like" evidence="6">
        <location>
            <begin position="370"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="35"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="247"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="323"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="55"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="277"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="292"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="338"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
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            <begin position="360"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00054756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00072052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBF88364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="529" mass="56852" checksum="C968EDE00CB665A8" modified="2005-04-26" version="1">MAATSHMHNLTTLIKRLEAATSRLEDMAMSLDEHDAQKKTADNSAALEPQASERPTPTAPAAPAAAPLPPQIEDFDTLISKDVGNFVQLGQKIGGLVAEQSNAVLEAFKAERTYLYVSTKAKKPEIQPPELMTGLHTASDAINNLRESNRASPLIDHLSAVAEGIVALGWFFDPKPADFVSEMLGGIQYYGNKVLKEYKEKDRTHYDYIQAYYQIFKSLSSYLRKHYPKGLTWNDKDGIDAQEALRQVKNSSDSAAGGAGTPPPPPPVPTLNIPGGGAPPPPPPPPPPPMISEQQSSGASSDMSAVFAQLNQGDAVTQGLRKVDKSQMTHKNPSLRASSTVPGSPSSSSRSKSPAPSKKPKPESMRSRKPPRKDLEGTKWFIENFDNPGDIVEIPAKQNQSILISRCNKTIIKVSSKANAIAIDNCHGLSIIVDSLVSSLDVVKCSKFALQIDGVAPTLLMDQVDGATVYLSSQSLGTELFSSKCTAVNVMLPPKEGTDEDTKECPVPEQIKTSVKDGVLVSEIVEHAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BF41</accession>
    <accession>C8VQD4</accession>
    <name>Q5BF41_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ANIA_00839</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF88681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_658443.1">
        <property type="nucleotide sequence ID" value="XM_653351.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BF41"/>
    <dbReference type="STRING" id="227321.Q5BF41"/>
    <dbReference type="GeneID" id="2876617"/>
    <dbReference type="KEGG" id="ani:ANIA_00839"/>
    <dbReference type="HOGENOM" id="CLU_046730_0_0_1"/>
    <dbReference type="InParanoid" id="Q5BF41"/>
    <dbReference type="OMA" id="HHIHAID"/>
    <dbReference type="OrthoDB" id="5295747at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.370.10">
        <property type="entry name" value="AttH-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023374">
        <property type="entry name" value="AttH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053112">
        <property type="entry name" value="Fungal_Dehydratase/Hydratase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40617:SF1">
        <property type="entry name" value="ATTH DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40617">
        <property type="entry name" value="TERPENE CYCLASE ASQC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17186">
        <property type="entry name" value="Lipocalin_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159245">
        <property type="entry name" value="AttH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF88681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="447" mass="48975" checksum="156EDFB507106F3C" modified="2005-04-26" version="1">MSWAALSPETPAFSGTRAVVPPTSVILTGNQEEWGYHSPATLLCIPKADSFDDRSLTLVVPSHICGILSTQEGVSSPFFFFCSIPESLVVLLVTDPAMYLPCLLLLFTRSLAYLFTPDNTETLIDHRIPVVFDVATSQTLSYAEAPISGFWITSFLTATDGSQYFLASGLLASESVSAYGASLLDLQTFQRHAFFDPATFTNANLESFNFTTQDYELSGIPPDNLAMKLSSDVPGASFDLILHATSRAAYYYGTGTYRYVNDTMYNWVFPATKTSGSITVPGQFGDDAEQIELDPAASLTWYDRVWGSAELRKGNSTFFVLYVDDSDLILWMNVVESLDPPFKSRSVNICARGKSWHHIHAIDVFEPDTDAVWTSPRTGKTYPQEWRLGIEGRGELHIKSVIGDQELAAKGNDGAGIYMGFSTFEGVLDGEDVTGFGVSELRLAGIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="118" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BF74</accession>
    <accession>C8VQH0</accession>
    <name>Q5BF74_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WD repeat protein (AFU_orthologue AFUA_1G14650)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ANIA_00806</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF88747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_658410.1">
        <property type="nucleotide sequence ID" value="XM_653318.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BF74"/>
    <dbReference type="FunCoup" id="Q5BF74">
        <property type="interactions" value="705"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5BF74"/>
    <dbReference type="GeneID" id="2876585"/>
    <dbReference type="KEGG" id="ani:ANIA_00806"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN0806"/>
    <dbReference type="eggNOG" id="KOG1188">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037323_3_1_1"/>
    <dbReference type="InParanoid" id="Q5BF74"/>
    <dbReference type="OMA" id="PLGCEYV"/>
    <dbReference type="OrthoDB" id="25131at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039328">
        <property type="entry name" value="WDR89"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22889">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 89"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22889:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 89"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="56"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="149"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="331"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="350"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBF88747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="360" mass="39910" checksum="EFEB51340C6A2567" modified="2005-04-26" version="1">MHMLKQISSSSLGLPEDSYIYSIVPSSRTGFAAISSDDSLRIFDANELSHASLVASNVHDGVTSLRTYDASNQLVVTGGRDGKVKLWDLRNGKKSAVVAVQSSNQAPVLSTANCSETNSIVAGTELHSHQAIVAFWDVRSPNQPRLEYVESHNDDVTELQYHPNRHNILLSGSTDGLVNIYNTTITDEDEALVQVINHGSVHRAGFINERTIYALSHDETFSIHPATDPDEEAQEPEPIQFGDLRQPLNCEYIAQLCLGSQGPYIAAGNKVDKRLDLIPLAQSPSWRFDEQNLWRLPGGHGEEVVRSIHIDEQNQSVFTCGEDGLVRAWKPEGEQGQEAQMGTPRHKEKKTKEKARYKPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BFB8</accession>
    <accession>C8VQX1</accession>
    <name>Q5BFB8_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein CASP</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">ANIA_00762</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="16">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CASP family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF88835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_658366.1">
        <property type="nucleotide sequence ID" value="XM_653274.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BFB8"/>
    <dbReference type="FunCoup" id="Q5BFB8">
        <property type="interactions" value="220"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5BFB8"/>
    <dbReference type="GeneID" id="2876539"/>
    <dbReference type="KEGG" id="ani:ANIA_00762"/>
    <dbReference type="eggNOG" id="KOG0963">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016758_0_0_1"/>
    <dbReference type="InParanoid" id="Q5BFB8"/>
    <dbReference type="OMA" id="WQQEGFN"/>
    <dbReference type="OrthoDB" id="10257567at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012955">
        <property type="entry name" value="CASP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057476">
        <property type="entry name" value="Cux_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14043">
        <property type="entry name" value="CCAAT DISPLACEMENT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14043:SF2">
        <property type="entry name" value="HOMEOBOX PROTEIN CUT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08172">
        <property type="entry name" value="CASP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25398">
        <property type="entry name" value="CUX1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="666"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="domain" description="Cux N-terminal" evidence="14">
        <location>
            <begin position="34"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="CASP C-terminal" evidence="13">
        <location>
            <begin position="451"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="393"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="442"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="547"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="162"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF25398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CBF88835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="732" mass="81132" checksum="9B15C46D16B3F55C" modified="2005-04-26" version="1">MDSFAITEGIIPQSEKQDAQAPESGLGPALPEGANKFQRAIAAWRGIDLSNTLAKLDSTASDIVAEQRDALVQRKDLAQKTKDFRKLDDASKLAEYKGLLKAYQGFIDLLTNQGKSSSSAFLQLYSSLSEAPDPYPLLEASIDSLVVAEETVPKLTSERDQLQSSVDRLTSQLEDTERRLEEERAARKKLEDNQDAKIKEIETSWSAVLTEKTNNWTSKEKSLEEKVENQERLIKELKASYEVSQRLGQTDESGNHPQGGATAAELELVSSELEKTSLRLAEMEGRNEQLRLELAQAVSHSKEERTTSIDDDPGYLRLQSENSSLLRKLDAARFDRESERHTWEAKLLQSERQFSKVNAEKEELKTRLEKVADYEDIRRELEMIKSIEFSAGDDEEAGDLNDGTNGTVDKAKEGGKNGSLEQLLLARNKKLTDELTVLRVSHRDLQGQLETLREDLSTTKEELEKSQNLSTTLENDLLRLQQEAANAFPSSAMSVAGTYVSKYPHSSRRGVSPTSSIISGFDQSAASNNTMDAIRAGEAVGGGSGLLPMIQAQRDRFKKKNTELEEELSKLYSTVKSLRQEVASLQKDNLNLYEKTSASSIHTSADTPSGLSIDRYQSAYEAQISPFAAFRGRESTRAYKRMSLPERVVFSLTRIILANRTSRNLFAGYCFALHILLFIMLYMMSTMEIESHSAASLGAAAGAAMNAAGNGNAYSGQLDGDDWQQEGFNHAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BFM3</accession>
    <accession>C8VRZ6</accession>
    <name>Q5BFM3_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Mitochondrial outer membrane protein (Sam35), putative (AFU_orthologue AFUA_1G13180)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ANIA_00657</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF89045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_658261.1">
        <property type="nucleotide sequence ID" value="XM_653169.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BFM3"/>
    <dbReference type="STRING" id="227321.Q5BFM3"/>
    <dbReference type="GeneID" id="2876434"/>
    <dbReference type="KEGG" id="ani:ANIA_00657"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN0657"/>
    <dbReference type="eggNOG" id="KOG3028">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055680_0_0_1"/>
    <dbReference type="InParanoid" id="Q5BFM3"/>
    <dbReference type="OMA" id="RNAWLYT"/>
    <dbReference type="OrthoDB" id="198787at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001401">
        <property type="term" value="C:SAM complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd03193">
        <property type="entry name" value="GST_C_Metaxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03078">
        <property type="entry name" value="GST_N_Metaxin1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033468">
        <property type="entry name" value="Metaxin_GST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050931">
        <property type="entry name" value="Mito_Protein_Transport_Metaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021211">
        <property type="entry name" value="SAM35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12289">
        <property type="entry name" value="METAXIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12289:SF44">
        <property type="entry name" value="OUTER MEMBRANE PROTEIN (SAM35), PUTATIVE (AFU_ORTHOLOGUE AFUA_1G13180)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17171">
        <property type="entry name" value="GST_C_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17172">
        <property type="entry name" value="GST_N_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10806">
        <property type="entry name" value="SAM35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin-like fold" evidence="3">
        <location>
            <begin position="82"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="Metaxin glutathione S-transferase" evidence="2">
        <location>
            <begin position="229"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBF89045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="299" mass="34290" checksum="EAA53E8DA4F51833" modified="2005-04-26" version="1">MTSNYDDHDLPQQRPDSRRAPRRVRDFFSVPAPVKRVFDRFPLLTYPANDLPHHAGSGRSGNQLFVFIDAAGARRGRPSFNPQCLKWQAYLRFMGIDFELVPSNNHASPSGFLPFLLPALPVGTDAPIPSNKLQNWAIEEVHCEEEQQLNVRFEVYSSLLDTRIRNAWLYHLYLNHENFEAVARRLYVDPSTTNTAVRFALAAQLQQAARDELLKSSPYIDAGALEAEAAEAFEALSTVLGDKDYFFERPNPGLFDASVFAYTHLILDQKMGWKYNRLQQLLSQYKNLVQHRARLLEFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BFP5</accession>
    <accession>C8VS19</accession>
    <name>Q5BFP5_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_00635</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF89088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_658239.1">
        <property type="nucleotide sequence ID" value="XM_653147.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BFP5"/>
    <dbReference type="GeneID" id="2876412"/>
    <dbReference type="KEGG" id="ani:ANIA_00635"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN0635"/>
    <dbReference type="eggNOG" id="ENOG502S685">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_110797_1_0_1"/>
    <dbReference type="InParanoid" id="Q5BFP5"/>
    <dbReference type="OMA" id="NPSDPIH"/>
    <dbReference type="OrthoDB" id="3260716at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF89088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="177" mass="18696" checksum="E1BB49F333015D27" modified="2005-04-26" version="1">MSHFSNVPNQKQGEFQPGPAPSGNYQQPNGPWPNDKHAPGVKASPADNVPEFHAETHPPGTAPASSSYQPNPIDHSGEQAMNPNVLRSHGKEEVRTSAESTLMGATSKDVHQGAGHPGSGQSSAELRHDGQHTNKNPGRGLEGAMKGVRDDFGTRTDQYLSKKPTAAEGSHAEGSRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BGJ3</accession>
    <accession>C8VU02</accession>
    <name>Q5BGJ3_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ANIA_00337</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF89694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_657941.1">
        <property type="nucleotide sequence ID" value="XM_652849.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BGJ3"/>
    <dbReference type="STRING" id="227321.Q5BGJ3"/>
    <dbReference type="GeneID" id="2876115"/>
    <dbReference type="KEGG" id="ani:ANIA_00337"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN0337"/>
    <dbReference type="eggNOG" id="ENOG502SIXT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059226_0_0_1"/>
    <dbReference type="InParanoid" id="Q5BGJ3"/>
    <dbReference type="OMA" id="VHLICWY"/>
    <dbReference type="OrthoDB" id="25129at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF89694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="371" mass="41651" checksum="B90B0C6BD28B9A40" modified="2005-04-26" version="1">MTELEVKETVALGLSSSPFACSSLTQLSGGTANFVYRGVLSRPLPNGTTTVIVKHAEEYLASNSDFKLTAKRCLVEEAALRALDGMQSETTTKEDSDFDQKHQVIVKSPKLLHFSRSTYTQVMEDLPDSVDLKTFLLSSDISERVSKEWVLSIGRTIGSWLRLFHVWSIHPAQSKFAEQLAENTVMRDLKFSINYDSLVSMIDAYPDILGDSHTSPGPLYSTLQLNADGTSVLIPKTAFEDQAASPTTPTPLFITDWELAQHGTRALDLGQMIAELYMLNHYKDTDAGLWVIEGFLQGYGYQHIPVKIAFRTLIHVGVHFIFWGSTTPGWGSQEQVLDLVKLGRELVVRAWETDRTWFEGKFWEVFFKART</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BHE1</accession>
    <accession>C8VRE4</accession>
    <name>Q5BHE1_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UPF0052 domain protein (AFU_orthologue AFUA_5G12650)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_00039</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF90324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_657643.1">
        <property type="nucleotide sequence ID" value="XM_652551.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BHE1"/>
    <dbReference type="FunCoup" id="Q5BHE1">
        <property type="interactions" value="54"/>
    </dbReference>
    <dbReference type="GeneID" id="2875813"/>
    <dbReference type="KEGG" id="ani:ANIA_00039"/>
    <dbReference type="eggNOG" id="ENOG502QUXN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019029_3_0_1"/>
    <dbReference type="InParanoid" id="Q5BHE1"/>
    <dbReference type="OMA" id="RITRIWY"/>
    <dbReference type="OrthoDB" id="10267139at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043743">
        <property type="term" value="F:LPPG:FO 2-phospho-L-lactate transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07187">
        <property type="entry name" value="YvcK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10680">
        <property type="entry name" value="CofD-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002882">
        <property type="entry name" value="CofD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038136">
        <property type="entry name" value="CofD-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31240">
        <property type="entry name" value="MATERNAL EFFECT EMBRYO ARREST 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31240:SF0">
        <property type="entry name" value="MATERNAL EFFECT EMBRYO ARREST 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01933">
        <property type="entry name" value="CofD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142338">
        <property type="entry name" value="CofD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="395"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="410"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF90324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="535" mass="57474" checksum="93742791661E4F4B" modified="2005-04-26" version="1">MSSTPSAPNRGLVVFSGGSAANNLVEVFNSVRESKDCPLSYIIPISDNGGSSSELIRIFGGPGIGDVRSRLVRLIPPSPPNSERAAIKKLFNYRLPADESAHSEWLAIVDGTSSLWKSITPAKKELIRSFFNLLNLEILKRARPPSSTFDFSSASVGNLFLTGARLFSGSFESAIYLLGSICDVSSDLIRVIPAINSNFSHHISASLANGTIIVGQNSISHPSLPPRPASPRPRKALHAEENGNGANAELAITIDYTEPSDVLDTALYEDDQPPGFLPHLRNKNINFSKSENEDLPARITRVWYINPYGQEIRPRANPRVLESLRDAQAIIYSIGSLYTSLIPSIILQGVGQAIVSSPARHKILILNGSLDRETGPSSDPFTAADFVEAITRAGEESRGRVTLEPPQSPPSTSSLGSTTGPGAFPSLFPNGHGSSKSALPYTSYITHVLHLEGPGTPHVDKDRLAEMGIETLRLYGRKIVASTDGAEAEVPIGMRYDSNGLIQALEVVLGKKGDGMIRGSVSRRNTLDPGRKRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BHG2</accession>
    <accession>C8VRI2</accession>
    <name>Q5BHG2_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ANIA_00007</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF90396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_657611.1">
        <property type="nucleotide sequence ID" value="XM_652519.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BHG2"/>
    <dbReference type="GeneID" id="2875782"/>
    <dbReference type="KEGG" id="ani:ANIA_00007"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN0007"/>
    <dbReference type="HOGENOM" id="CLU_013866_5_0_1"/>
    <dbReference type="InParanoid" id="Q5BHG2"/>
    <dbReference type="OMA" id="AVTMSHI"/>
    <dbReference type="OrthoDB" id="4220372at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053175">
        <property type="entry name" value="DHMBA_Reg_Transcription_Factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR DBAG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF90396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="311" mass="34982" checksum="3CD318B2E999E20D" modified="2005-04-26" version="1">MAVISLGVFEHISNFESWVRHVKGAAALVVARGKSQFARRSAILMFNQVRADMATACIQTVQPFPADLQELQEEATKYTDRWDASWLAGILATRCATLFAGVAKKHQDKFLETPRSWADFLEEAIAIQSDFQHVLDMLALQEPYITTRELRGSTTFVSCNGQYDLYKTTWAIRLWNNCRTVEIIVCKIICWLINQILTEESARPASSQLKLQSKLRYTMQVISRRSTDILASVPQGLGLVSVPDADIPQEPSVSGGYMLIWNLYTVGKSPAISAQDRQWIIKQLKGISERANIAMAFELAKDLVKIGRTEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>C8UZY7</accession>
    <name>C8UZY7_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF8035 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_10752</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF70672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467068.1">
        <property type="nucleotide sequence ID" value="XM_050612641.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8UZY7"/>
    <dbReference type="STRING" id="227321.C8UZY7"/>
    <dbReference type="GeneID" id="74896583"/>
    <dbReference type="KEGG" id="ani:ANIA_10752"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN10752"/>
    <dbReference type="eggNOG" id="ENOG502SSBZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053162_0_0_1"/>
    <dbReference type="InParanoid" id="C8UZY7"/>
    <dbReference type="OMA" id="YREVEVH"/>
    <dbReference type="OrthoDB" id="5549748at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058348">
        <property type="entry name" value="DUF8035"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26118">
        <property type="entry name" value="DUF8035"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF8035" evidence="2">
        <location>
            <begin position="167"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="280"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF70672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="383" mass="45112" checksum="73D763238F90BC00" modified="2009-11-03" version="1">MPRFSDSRSGFDSETEYFSRESRGRHHSRGAAVLERPPRRVEDEFRWDSRLQETDRYGPPARRPSRHYDDDHLRHGGALVRVDRRHAESPPPRPRMLRRQSSLDTYDRLPSRKIDEYYHGYLPRAAPSPPPSRRRTRRDEFETIQVPARESWYRETETVKDTRPYPRKGKTRMPQNLVNTRAIREFGYPYEREGDLIIIQLALSKEQIDAVIERSRELKRQPEIIPIRARSPVRATSRRRKVETITMEPRASETLIVEPSPSPEPYFSAEPRGYDYSTTTARRTVSRSRSISVRPRRRRYSSPPRMIMERRSDHTEAPGQIMIVRPRDSDSDLDDYAIDNYRPPFDPSTALYGDADEEEVLEVKQNRRGPPARTLRRMLATMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>C8V0F4</accession>
    <name>C8V0F4_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4396 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_10816</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF69484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050466926.1">
        <property type="nucleotide sequence ID" value="XM_050612681.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V0F4"/>
    <dbReference type="STRING" id="227321.C8V0F4"/>
    <dbReference type="GeneID" id="74896618"/>
    <dbReference type="KEGG" id="ani:ANIA_10816"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN10816"/>
    <dbReference type="eggNOG" id="ENOG502S2G1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080767_0_0_1"/>
    <dbReference type="InParanoid" id="C8V0F4"/>
    <dbReference type="OMA" id="MWFLQAY"/>
    <dbReference type="OrthoDB" id="2128064at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025509">
        <property type="entry name" value="DUF4396"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14342">
        <property type="entry name" value="DUF4396"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4396" evidence="2">
        <location>
            <begin position="88"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF69484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="227" mass="24758" checksum="27C582F9867196B6" modified="2009-11-03" version="1">MLFFSRLTASLPCQPRLRMRFHRRISRLGGDSGAFPSVYAADRSCHTGGQKTNSSSKSACKAQSQTDQNQKSDTSALLTRRFWTCRSTWRRAGINTLRCLVGCTVGDFAALWTLQTYCPELGMGTIMAASMASGITTSIILETVLLRHGPDRLPWSAAVRTAMGMSLVSMAAMEAAENLVDYHLTGGVINLNDPAFWIAAGVSIGAGFLAPLPYNYWRLRALGRSCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C8V7K3</accession>
    <name>C8V7K3_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Genetic interactor of prohibitins 3, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_10438</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF75572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_661309.2">
        <property type="nucleotide sequence ID" value="XM_656217.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V7K3"/>
    <dbReference type="STRING" id="227321.C8V7K3"/>
    <dbReference type="GeneID" id="2873127"/>
    <dbReference type="KEGG" id="ani:ANIA_10438"/>
    <dbReference type="eggNOG" id="KOG1249">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015286_0_0_1"/>
    <dbReference type="InParanoid" id="C8V7K3"/>
    <dbReference type="OMA" id="GWLNNKP"/>
    <dbReference type="OrthoDB" id="1696305at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050896">
        <property type="entry name" value="Mito_lipid_metab_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46434">
        <property type="entry name" value="GENETIC INTERACTOR OF PROHIBITINS 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46434:SF1">
        <property type="entry name" value="GENETIC INTERACTOR OF PROHIBITINS 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="340"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="611"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="618"/>
            <end position="634"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF75572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="634" mass="70518" checksum="B62286123CE05D94" modified="2009-11-03" version="1">MSPRVLWKFPRQCQQAQRFFRSQHPPSRFRREVVCGLALLSTVQLRRQSTSASNPVSSTESTQAVLPLCCPGCGAYSQTVEPNEPGFYSKTRKQTRKLLLEAQKEPLKESATQEAVFTVQKAVEEAEIAPKPHPDTVSQYLEKSQSPVQVCDRCHDLLHHNKGVSAISPSIHSIGAYLDESPHKHNRIYHIIDAADFPMSLVDGIYEELGIQEQRSRNRRSATYKYKHGKKLPTITFVITRSDLLGPTKELVDSKMEFVRSVLREKLGISSEEFRLGNVHMISAHRGWWTKKVKEEMREHGGGIWIVGKANAGKSSFVQACIPKDSRNLEKMAELIARRGEASPAPSLDDQPAFDPDSLLPPAPNEDLYPVLPIVSSLPGTTVSPIRIPFGRGKGEIIDLPGLSRGDLADYVQDEYKRDLIMTKRGKPERHTIKPGQSLLIGGGLIRITPLDLDTIVLAAAFIPIETHLTRTDKAAEMQAQERPYPGTNIVKEGTGALIKSVGIFDLKWDVTRSHLPTSIAKAVEDHGIKPPPLPYKVMSADILIEGCGWVELTAQIRAKAFKNSDGYGDGSTESSTHFPRVEVFSPNGKHVEVRRPIQSYEFTAKKAAAEKRAIGARGRRNVGHMKRKQNQKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>C8V9M3</accession>
    <name>C8V9M3_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">ABC multidrug transporter (Eurofung)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">ANIA_08813</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF77968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467783.1">
        <property type="nucleotide sequence ID" value="XM_050611798.1"/>
    </dbReference>
    <dbReference type="GeneID" id="74896138"/>
    <dbReference type="KEGG" id="ani:ANIA_08813"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN8813"/>
    <dbReference type="eggNOG" id="KOG0065">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_35_0_1"/>
    <dbReference type="InParanoid" id="C8V9M3"/>
    <dbReference type="OMA" id="YCAQFGM"/>
    <dbReference type="OrthoDB" id="245989at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03233">
        <property type="entry name" value="ABCG_PDR_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03232">
        <property type="entry name" value="ABCG_PDR_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001010">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000054">
        <property type="entry name" value="ABC multidrug transporter atrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029481">
        <property type="entry name" value="ABC_trans_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034001">
        <property type="entry name" value="ABCG_PDR_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034003">
        <property type="entry name" value="ABCG_PDR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010929">
        <property type="entry name" value="PDR_CDR_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14510">
        <property type="entry name" value="ABC_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06422">
        <property type="entry name" value="PDR_CDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="517"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="552"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="592"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="626"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="659"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="690"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="765"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1210"/>
            <end position="1231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1254"/>
            <end position="1282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1294"/>
            <end position="1316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1322"/>
            <end position="1342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1446"/>
            <end position="1464"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="148"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="843"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="76"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CBF77968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="1480" mass="166579" checksum="A08A29FECBCD58F1" modified="2009-11-03" version="1">MDEKQGTSTGSDADTLNSSYEQSREWIRHSNPQGVVSHDSGVNVERAEQEFAELNREFSNISYQVQRLSKHASRNSKTEIHGKDVERSASSTDSVEPWDLEAALRGNQAAEVEAGIKSKHIGVIWDKLTVRGIGGSKSFIKTFPDAIVDFINVPGLIMDWTGHSNKGKEFEILKDFRGVLRPGEMVLVLGRPGSGCTTFLKSITNQRFGYTGVDGEVLYGPFDHKTFSKRFRGEAVYNQEDDVHQPTLTVKQTLGFALDTKTPGKRPLGVSKEEFKDKVIRMLLKMFNIEHTANTVVGNQFIRGVSGGEKRRVSIAEMMITSASVLAWDNSTRGLDASTALDFAKSLRIMTNIYKTTTFVSLYQASESIYKQFDKVLVIDSGRQVFFGPASEARAYFEGLGFKEKPRQTTPDYLTSCTDPFEREYKEGRDPSNVPSTPEALAAAFDNSIYSQNLATEMNEYRQQIHHEKQVYEDFEIANQEAKRKFTSKSSVYLIPYYLQVWALMRRQFLIKWQDKFALNVSWITSTGVAIILGTVWLNLPKTSAGAFTRGGLLFTSFLFNGFQAFSELASTMMGRALVNKHRQFTFYRPSALFIAQIIVDATFAIARILVFSVIVYFMCGLVRDAGAFFTFVLLIFTGYINMSVIFRTIGCLSPAFDHAMNFVSVLITLFILTSGYLVQWPNAQVWLRWFYYINPFGLGFASLMVNEFKSLNMTCTSESLIPNGDGYTDMNHQVCTLAGGEAGSPIIPGQSYLSTTFNYNREDLWRNFGIMVALIIAFLGMNLYFGEVVRFNAGGKTVTFYQKENAGRKKLNKALDEKRAARQSNDLGGPGADILLTSKPVLTWEDVCYDVPVPSGTRRLLHNIYGYVQPGKLTALMGASGAGKTTLLDVLAARKNIGVISGDILVDGAKPGTSFQRGTSYAEQMDVHEPMQTVREALRFSADLRQSYDVPQSEKYAYVEEIISLLELENLADAVIGTPETGLSVEERKRVTIGVELAAKPEMLLFLDEPTSGLDSQSAFNIVRFLRKLAAAGQAILCTIHQPNSALFENFDRLLLLKSGGECVYFGDIGEDSSTLLAYFRRNGAECPPDANPAEWMLDAIGAGSTRHLGNCDWVEFWRASPERERVKQEIAEIKSRRAEEARRNQATKPVEKEYATPLWHQIKTVCKRTNIVFWRSHKYGFTRLFTHFNISLITGLAFLQLDDSRASLQYRIFVLFNVTVIPIIIIQMVEPRYEMSRLVFYREAASKTYKDFAFAVSMVVAEIPYCIMCGIIFFVFLYYIPGFQGASDRAGYQFFMIMITQLFAVTLGQMIQALTPNSMIASQCNPPLMILFSLFCGVMIPKPQMPKFWRVWFYELDPFTRIISGMVTTELHERPVVCTPGEYNRFQAPAGQTCGEYMQSFFDRGGIGYLANNATQNCEYCAYRVGDEYYQAFEMSFDHRWRDLGIYAAFVGSNLIILFMAVRLSDLQALPSGDWLTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>C8VAA0</accession>
    <name>C8VAA0_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-acetylgalactosaminide beta-1,3-galactosyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.122</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">ANIA_04824</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 31 family. Beta3-Gal-T subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.122" evidence="4"/>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF76694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_662428.2">
        <property type="nucleotide sequence ID" value="XM_657336.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VAA0"/>
    <dbReference type="STRING" id="227321.C8VAA0"/>
    <dbReference type="GeneID" id="2872625"/>
    <dbReference type="KEGG" id="ani:ANIA_04824"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN4824"/>
    <dbReference type="eggNOG" id="KOG2246">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022549_3_1_1"/>
    <dbReference type="InParanoid" id="C8VAA0"/>
    <dbReference type="OMA" id="FYRKPWC"/>
    <dbReference type="OrthoDB" id="414175at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016263">
        <property type="term" value="F:glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026050">
        <property type="entry name" value="C1GALT1/C1GALT1_chp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003378">
        <property type="entry name" value="Fringe-like_glycosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23033:SF47">
        <property type="entry name" value="APPLE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23033">
        <property type="entry name" value="BETA1,3-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02434">
        <property type="entry name" value="Fringe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="Fringe-like glycosyltransferase" evidence="13">
        <location>
            <begin position="193"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CBF76694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="459" mass="52420" checksum="A07E7BC6A9147971" modified="2009-11-03" version="1">MSSVKLGRFTYRLVPQQFRCRMGSHRGIRRRVAVVATLLTLFLIYHFTIGSVPYQPSSSQYTNSARTSSDKKQSQCLPLPGIEDVLVVMKTGVTEALDKVPVHFKTTLRCIPNYVIYSDFEEKIDGVQIHDAFRNIDPAVKQNVDDFQIYNRLSKRGREGLQTQDFADEANSAIGKPNNPGWKLDKWKFLPMVKEAHQYKPDAKWFVFMEADTYYSWPTLLAWLSHFDPSEPHYIGTETQIADVIFAHGGSGFVLSNPAMKLAADEYTERADELHEYTDAHWAGDCVLGKVLSNVGVNLSFSWPILQNSNIGELDEFTTTFYRRPWCFPAVALHHLSPDDIRFLHDFEHRRLAKSSRLPLLHSDIFKELIFPELSNVRNGWDNLSDKEQPTLSTFQECQSYCKETANCVQFVMRDGTCYTGETPRLGSHNSNAQSGWIINKIENMVDQAPQCVRPDFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>C8VC15</accession>
    <name>C8VC15_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">GTP cyclohydrolase II, putative (AFU_orthologue AFUA_2G01220)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ANIA_10981</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GTP cyclohydrolase II family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF79847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468011.1">
        <property type="nucleotide sequence ID" value="XM_050612052.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VC15"/>
    <dbReference type="STRING" id="227321.C8VC15"/>
    <dbReference type="GeneID" id="2869486"/>
    <dbReference type="KEGG" id="ani:ANIA_10981"/>
    <dbReference type="eggNOG" id="KOG1284">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029639_1_0_1"/>
    <dbReference type="InParanoid" id="C8VC15"/>
    <dbReference type="OMA" id="FQQLMPD"/>
    <dbReference type="OrthoDB" id="57939at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003935">
        <property type="term" value="F:GTP cyclohydrolase II activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00641">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10990">
        <property type="entry name" value="GTP cyclohydrolase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022163">
        <property type="entry name" value="GTP_CH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032677">
        <property type="entry name" value="GTP_cyclohydro_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000926">
        <property type="entry name" value="RibA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036144">
        <property type="entry name" value="RibA-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005536">
        <property type="entry name" value="PRK07198.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47259">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47259:SF2">
        <property type="entry name" value="URACIL-REGULATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12471">
        <property type="entry name" value="GTP_CH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00925">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142695">
        <property type="entry name" value="RibA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GTP cyclohydrolase N-terminal" evidence="7">
        <location>
            <begin position="29"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="GTP cyclohydrolase II" evidence="6">
        <location>
            <begin position="262"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBF79847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="446" mass="49553" checksum="4976E3CD7735F4EE" modified="2009-11-03" version="1">MTSDDTNVPPKDAETTAVQSPTSASRYSKHIVLTTYPGQSGIDPVPLEWGAPDAESRGPVVVSRSGAFVKRRNAMGAHGGSYSIYNALAIAAGDLDPNFRPNFVNTEPTFDFPWQPAWSDKTKIVSMDPYGHDVVKYFSDKINAGWDIRPTMAVTRANMKLAEIGEAVRDGLLEVDGSIVVDSTGEVRVTKVAVEPVWYLPGVAERFGVDEPTLRRTLFEHTGGSYPELITRPDLKVFLPPIGGLTVYIFGPPERVSDENVKLALRIHDECNGSDVFQSDICTCRPYLAFGIREAIREAQNGGSGVVIYFRKEGRALGEVTKYLVYNARKRGGDTADKYFTRTENIAGVRDMRFQALMPDILHWLGIKKIDRMLSMSNMKHDAIVESGIKIVERIPIPEDMIPDDSRVEIDAKINAGYFTTGKAYTMEELAQVRGRGWEKWEDITH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>C8VCS3</accession>
    <name>C8VCS3_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein mL46</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ANIA_10922</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL46 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF78699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467859.1">
        <property type="nucleotide sequence ID" value="XM_050611883.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VCS3"/>
    <dbReference type="FunCoup" id="C8VCS3">
        <property type="interactions" value="415"/>
    </dbReference>
    <dbReference type="STRING" id="227321.C8VCS3"/>
    <dbReference type="GeneID" id="74896680"/>
    <dbReference type="KEGG" id="ani:ANIA_10922"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN10922"/>
    <dbReference type="eggNOG" id="KOG4548">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040204_1_0_1"/>
    <dbReference type="InParanoid" id="C8VCS3"/>
    <dbReference type="OMA" id="HPFENAF"/>
    <dbReference type="OrthoDB" id="414075at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd04661">
        <property type="entry name" value="NUDIX_MRP_L46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000018">
        <property type="entry name" value="39S ribosomal protein L46, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040008">
        <property type="entry name" value="Ribosomal_mL46"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021757">
        <property type="entry name" value="Ribosomal_mL46_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033650">
        <property type="entry name" value="Ribosomal_mL46_NUDIX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13124">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L46, MITOCHONDRIAL PRECURSOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13124:SF12">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11788">
        <property type="entry name" value="MRP-L46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Large ribosomal subunit protein mL46 N-terminal" evidence="9">
        <location>
            <begin position="63"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="168"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="168"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="180"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF11788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBF78699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="338" mass="38049" checksum="6B5B97B9AF7FD2FC" modified="2009-11-03" version="1">MSSGSNGARRIASILRPSIAEQRVCSSCQETLVRRNYASAATPISPKPSSSTSSTFPVVSPTYTINAGVLLSRPPQITRDLTDFEKAYYFYQKRLNERLALPFTKYFYFKRGTPLDEDWKRKVRERQTAARDIGKYNAYGKEAWNDELLLGAKESEPEHIVEALISDAESTANNTSQDTSKQEQIPRPHPRVTEADKKGDTKSLDRALQRTLYLLVQHKEGYWKLPSSPVASGETLRSAAERTLEQSAGVNMNTFMVGYHPVGHYVYNSRKPKIDETTGATLAGEKTFFMKGRIMAGQADLSANVQNLKDFKWLAKEEIAKYVLPPYYAAIKNMLAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>C8VDA1</accession>
    <name>C8VDA1_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SGNH hydrolase-type esterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_10894</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF79022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_664731.2">
        <property type="nucleotide sequence ID" value="XM_659639.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VDA1"/>
    <dbReference type="STRING" id="227321.C8VDA1"/>
    <dbReference type="GeneID" id="2869914"/>
    <dbReference type="KEGG" id="ani:ANIA_10894"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN10894"/>
    <dbReference type="eggNOG" id="ENOG502SPMP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_897231_0_0_1"/>
    <dbReference type="InParanoid" id="C8VDA1"/>
    <dbReference type="OrthoDB" id="1896086at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021986">
        <property type="entry name" value="Spherulin4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35040:SF7">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12138">
        <property type="entry name" value="Spherulin4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002993590" description="SGNH hydrolase-type esterase domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="132"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF79022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="310" mass="34018" checksum="720138F3BAE14798" modified="2009-11-03" version="1">MRLGYCLCLCGLLASSAVLAQDIDYGAAAESISAVLADPTFVPYAKPTQKVSEWIAVGDSYSAGTGCNGNNKRMGRDAVPFHAYTSNKVQDLVVHQLKQGDYREGNDLPRNQPFSKPQLASSSPGQLPGNAQQPPTGTRQQQLPGQGQLQAVPGRTCRTRGRRRQPARKLPGLCPGICDLLRDRRRMQRLLVVLLWVEHPETQPGGDWGQQIAIASYINPLGDPASWERLLAYDTNKVSVLVANVLNSPDYVVDDSWKSVIDQAASQGKKILGYVRTGYLGVSQQQFTTRLGSRDLADWASQIEQDIDKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>C8VEV6</accession>
    <name>C8VEV6_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ANIA_10633</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF80849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VEV6"/>
    <dbReference type="HOGENOM" id="CLU_3428518_0_0_1"/>
    <dbReference type="InParanoid" id="C8VEV6"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF80849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="20" mass="2237" checksum="72B5088F1A5569FC" modified="2009-11-03" version="1">MQVLGYANQLLGQVKVFISK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>C8VF57</accession>
    <name>C8VF57_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dienelactone hydrolase family protein (AFU_orthologue AFUA_1G07130)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_10652</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF81035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468160.1">
        <property type="nucleotide sequence ID" value="XM_050612216.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VF57"/>
    <dbReference type="FunCoup" id="C8VF57">
        <property type="interactions" value="39"/>
    </dbReference>
    <dbReference type="STRING" id="227321.C8VF57"/>
    <dbReference type="GeneID" id="74896524"/>
    <dbReference type="KEGG" id="ani:ANIA_10652"/>
    <dbReference type="eggNOG" id="ENOG502QQFN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054590_1_0_1"/>
    <dbReference type="InParanoid" id="C8VF57"/>
    <dbReference type="OMA" id="CATCFFP"/>
    <dbReference type="OrthoDB" id="58297at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47562">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47562:SF2">
        <property type="entry name" value="CARBOXYMETHYLENEBUTENOLIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="52"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF81035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="289" mass="31856" checksum="558B9BBC5252A2EC" modified="2009-11-03" version="1">MLIKEYHHDVPTVADGNGSMRRAFLNLLYPAIKLKALAGIYVFHPSIPGYPNARFPGVVVFSEIYQVTGPVARFARQIAGQGYIVACPSSYHEFTGPEALSYNAEDTDKGNEWKVSKKLSAYDEDASLSVSYLISLPTCTGRIGATGMCLGGHLAYRCALDERVKAAVCYFATDIHSHTLGKGKNDDSLARAGDIKGELVMIFGKNDTHVPPEGRDLIRSTLHEKGVLFSFYEVAWAQHAFIRDELSKGRYDPAISKVCFEMLLELFGRTLKLDLGDHDGKEVKVDDVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>C8VFV7</accession>
    <name>C8VFV7_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1</fullName>
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    </protein>
    <gene>
        <name evidence="14" type="ORF">ANIA_11487</name>
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    <organism evidence="14 15">
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
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            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I NDUFA1 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF81497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468221.1">
        <property type="nucleotide sequence ID" value="XM_050612280.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VFV7"/>
    <dbReference type="STRING" id="227321.C8VFV7"/>
    <dbReference type="GeneID" id="74897064"/>
    <dbReference type="KEGG" id="ani:ANIA_11487"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN11487"/>
    <dbReference type="eggNOG" id="ENOG502S786">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_132216_1_0_1"/>
    <dbReference type="InParanoid" id="C8VFV7"/>
    <dbReference type="OMA" id="EVSNPWK"/>
    <dbReference type="OrthoDB" id="1920692at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017384">
        <property type="entry name" value="NADH_Ub_cplx-1_asu_su-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17098:SF2">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17098">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE MWFE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15879">
        <property type="entry name" value="MWFE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="7 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CBF81497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="86" mass="9800" checksum="4A0BFE6F11343EA1" modified="2009-11-03" version="1">MGVPFEALIPYGIVVVMFGVTGVGLSVVKTYANDGKKARWNRDLWDRQMMERDLRLTGSLRGQSTNPEAPKGFEINNPWKVEKRLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>C8VGX8</accession>
    <name>C8VGX8_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Zn(II)2Cys6 transcription factor (Eurofung)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ANIA_10659</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF82140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468288.1">
        <property type="nucleotide sequence ID" value="XM_050612356.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VGX8"/>
    <dbReference type="GeneID" id="74896530"/>
    <dbReference type="KEGG" id="ani:ANIA_10659"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN10659"/>
    <dbReference type="eggNOG" id="ENOG502SIT3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004083_7_2_1"/>
    <dbReference type="InParanoid" id="C8VGX8"/>
    <dbReference type="OMA" id="YHGYEPI"/>
    <dbReference type="OrthoDB" id="435881at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF57">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="43"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="103"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="107"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBF82140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="687" mass="78030" checksum="3F7B0205FF2F4C1F" modified="2009-11-03" version="1">MRPRQNYLSFTALPLRECFIAFFSNSRKENLHILTMDTRLLRSCTLCRQRKVKCDRQQPCSNCTKAKTQCVFPPGLGRAPKRPRKAVEARLLAQLSRLESVVKRMEQQSQDATSRAASQPLSDGRDSKIDQKSGRLVIDEMHSCYVSSLPWSQLGDEIEELRDLLHQTSSEDEKEPSSSVIEGAGPNSALLGYRALAHSLQPYHPQIHQAVALFNIFSTNVTPLVRIFHMPTLHRVFWDAVASMETVDRNIEALLFAIYYAAIISLESSQCLDLLGLPRASALETYRFAVEQATARADLLNTQNLILLQATVLFLTALRNEDDSRTVWSLTSLVYHIAQAMGLHRDGQEFGLRPLETELRRRLWWHICLLDNRSTDYHGTEPIVQEAAFDTRMPLNINDTDLTAEMTQPPVEREGVTEMTFCLMRCHAIRAVWKLGYMAPRKKFGSAAADTHLDSANQDSLVNDLQHLLQDRYLKHCDTLNPFPRLALSVARIITLRLRMTILSPRCRTDKTAREHLFNITVQILRLSNDMLTSEDMRQWAWHSKTHLQCYSIAFLLAELCRRPPSPECDLAWECVTAVYERCNGMETEKRGPLWRSIQRLMERARHVREVQTSSTDGTGTEHPWKVAGEAMIANKDNIGPTVTATALEPQDRFSGVNSAMDPSMDMLNSFFPNLFDVSGMDISGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>C8VKD1</accession>
    <name>C8VKD1_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Phosphatidic acid phosphatase type 2/haloperoxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ANIA_02688</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the type 2 lipid phosphate phosphatase family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF84209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468565.1">
        <property type="nucleotide sequence ID" value="XM_050612670.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VKD1"/>
    <dbReference type="FunCoup" id="C8VKD1">
        <property type="interactions" value="364"/>
    </dbReference>
    <dbReference type="STRING" id="227321.C8VKD1"/>
    <dbReference type="GeneID" id="2873821"/>
    <dbReference type="KEGG" id="ani:ANIA_02688"/>
    <dbReference type="eggNOG" id="KOG2822">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019266_0_1_1"/>
    <dbReference type="InParanoid" id="C8VKD1"/>
    <dbReference type="OMA" id="ADDCPCY"/>
    <dbReference type="OrthoDB" id="301434at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042392">
        <property type="term" value="F:sphingosine-1-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046839">
        <property type="term" value="P:phospholipid dephosphorylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd03388">
        <property type="entry name" value="PAP2_SPPase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14969:SF28">
        <property type="entry name" value="DIHYDROSPHINGOSINE 1-PHOSPHATE PHOSPHATASE LCB3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14969">
        <property type="entry name" value="SPHINGOSINE-1-PHOSPHATE PHOSPHOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="61"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="168"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="475"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="10">
        <location>
            <begin position="90"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="381"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CBF84209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="505" mass="56516" checksum="0077E9FC19121A18" modified="2009-11-03" version="1">MGRPVVEGQPDAGLRSLDHYRNQLPPWRYWPRQKLLPLIRYETPYLAWCQEKIRTPALDSYFAFTANLGTHTFFMVFLPIFFWSGYPSLGRGMVHLLASGVFFSGFIKDLLCLPRPLSPPLQRITMSGSAALEYGFPSTHSTNAVSVAVYALYLLNSPDSTLSDGLNFFLQGITYLYVTSIVLGRLYCGMHGFFDVVVGSALGVLLAVLHCTFETAIDHYVQVGSGKQVALVVLVILALVRIHPEPADDCPCFDDSVAFAGVMIGAQVAYWNLARANATWTNPHPATLPHSRETMKPTLLRILPPVFRGLEKLGLVLPRRYFTNASQYTTVPSQLKDHEVMPSFSDIPSIVDNIRHPRRRAISIGPQSEADAYETLAYREKRRRDSLSSPYRGSPAIDANNDDASTSGTAYPKLSRKPSKLDEYEHMMGRGTTAIDRSQSPEGTEPFPEFVDHERDEEELFAQIKRPRVRYDVEVVTKLVVYSGIAWIVIDGANVLFEWIGLMSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>C8VLB3</accession>
    <name>C8VLB3_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_11155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF84600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468596.1">
        <property type="nucleotide sequence ID" value="XM_050612708.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VLB3"/>
    <dbReference type="GeneID" id="74896816"/>
    <dbReference type="KEGG" id="ani:ANIA_11155"/>
    <dbReference type="HOGENOM" id="CLU_2960725_0_0_1"/>
    <dbReference type="InParanoid" id="C8VLB3"/>
    <dbReference type="OrthoDB" id="5330253at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF84600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="59" mass="6241" checksum="9E91A8B8235477FD" modified="2009-11-03" version="1">MPRSLASSSSSQSDKTKTSQTSLSGKSDELAPGEAPVSLSGMQHLDRHGKVISTFSIEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>C8VME8</accession>
    <name>C8VME8_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">ANIA_10193</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF84937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468647.1">
        <property type="nucleotide sequence ID" value="XM_050612767.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VME8"/>
    <dbReference type="FunCoup" id="C8VME8">
        <property type="interactions" value="784"/>
    </dbReference>
    <dbReference type="STRING" id="227321.C8VME8"/>
    <dbReference type="GeneID" id="74896262"/>
    <dbReference type="KEGG" id="ani:ANIA_10193"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN10193"/>
    <dbReference type="eggNOG" id="KOG2345">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_109_1_1"/>
    <dbReference type="InParanoid" id="C8VME8"/>
    <dbReference type="OMA" id="AMHQYKV"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032889">
        <property type="term" value="P:regulation of vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006624">
        <property type="term" value="P:vacuolar protein processing"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd13986">
        <property type="entry name" value="STKc_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000550">
        <property type="entry name" value="Serine/threonine kinase 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000374">
        <property type="entry name" value="Serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000728">
        <property type="entry name" value="Serine/threonine protein kinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052239">
        <property type="entry name" value="Ser/Thr-specific_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45998">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45998:SF2">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10 13" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="32"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="169"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="354"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="182"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="207"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CBF84937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="419" mass="46252" checksum="0031C8FCFC9D3B9B" modified="2009-11-03" version="1">MAQYFFDLLYNFTDCMCCFPSSPQLKINNRSFKLLRLLGEGGFSYVYLVQDKSTSELFALKKIRCPFGQESVSQALKEVEAYSLFTSEKNIIHSIDHCVSTESGSKFRSDGGEAGSKTVYILLPYYQRGNLQDAINANLVNQTRFPEKRLMVLMLGVAQALRAMHQYRVKSGSGPTRKAKAVRKEGAEADVEMRKGKGKRRGSQPAGEEDSENEPLMDDEVTQSQEGYEDGNLRPYAHRDIKPGNIMIDDDGQSPILMDLGSLAPSPIAITSRSLALAVQDTAAEHSTMPYRAPELFDVKTGSIIDTKVDIWSLGCTLYACLVGKSPFEARSEETGGSLSMCVLGGDWRFPDEKSGATKGKGKASEQQKQDSAASISSPVKEVVRRCLQVEPADRPDIDELIQMLKEVIRELPDDDVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>C8VNE1</accession>
    <name>C8VNE1_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ANIA_10293</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF86643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_659944.2">
        <property type="nucleotide sequence ID" value="XM_654852.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VNE1"/>
    <dbReference type="GeneID" id="2875593"/>
    <dbReference type="KEGG" id="ani:ANIA_10293"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN10293"/>
    <dbReference type="eggNOG" id="ENOG502S1KN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039076_0_0_1"/>
    <dbReference type="InParanoid" id="C8VNE1"/>
    <dbReference type="OMA" id="TIMQTEF"/>
    <dbReference type="OrthoDB" id="545169at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046366">
        <property type="entry name" value="MPAB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36124">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36124:SF1">
        <property type="entry name" value="ER-BOUND OXYGENASE MPAB_MPAB'_RUBBER OXYGENASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF86643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="453" mass="52678" checksum="269777EB7514CCA5" modified="2009-11-03" version="1">MDKRISQVLAGLRQLPIRALLLDFWRDPRRRLELSAVTLAAYLLLQRSLRYRRLKRLQKVYRKYTTREEMASMTDHDAWKIQKEMLVMEFPSASLKALQFALFRTYGIPTISSLLLKTSQFSNPATSFKRYADTGALIGQFMAFEPSSERAQTAIARTKFLHVGYRNSGKILESDMLYTLSLFALEPIRFIDMFEWRSLSELEQCAIGTYWKSLGDALGISFADLPSGPHAFRDGFHFLEELRAWSLKYEEEYMKPSSSNQEVADKTMDVLVYALPRFLKPMGVKFATCMMDDRLREAMMYQSPSAAYKKVFSSLVAIRKFYLRYIALPRLNFQRIDIFTDEPNEYGRYYVNIYEAIPYYVKPTIWNRWGPGAWVRWAMGMPLPGDDDDKYYPHGFDLEDLGPKYFEGKGRRSVAEIRELLKKKRRGQAPFVPDLPSVEDAKYEVVDPDSPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>C8VNM3</accession>
    <name>C8VNM3_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Zn(II)2Cys6 transcription factor (Eurofung)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ANIA_02367</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF86702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_659971.2">
        <property type="nucleotide sequence ID" value="XM_654879.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VNM3"/>
    <dbReference type="STRING" id="227321.C8VNM3"/>
    <dbReference type="GeneID" id="2875202"/>
    <dbReference type="KEGG" id="ani:ANIA_02367"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN2367"/>
    <dbReference type="eggNOG" id="ENOG502SI0U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020030_3_1_1"/>
    <dbReference type="InParanoid" id="C8VNM3"/>
    <dbReference type="OMA" id="KQKAMGH"/>
    <dbReference type="OrthoDB" id="5380854at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053175">
        <property type="entry name" value="DHMBA_Reg_Transcription_Factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791:SF11">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="8"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="60"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="64"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBF86702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="528" mass="58526" checksum="9D34EF3B01ED6630" modified="2009-11-03" version="1">MGTPASKACHNCRRRRLKCDRAVPSCAKCFHTGQECLGYGKLFLWNQGVASRGKMMGKTFPVPGSESVSGSGSKSLPEPYDQKKEATTVPSQDALVYTGPGFFLSGPLLDPLYQSLDESSRRYLSHSDATNANPFRRLVPLCRDYPILRHAINAAGALHISCLHRRTGDPCDADRSVQRRHTFALDPTDPSSRALIDALSAKQRALALLRQALEDVSTIDVDLSIAVVHLFIIFELLSPGGDEWRAHVQGALRLISYLQTLTPRRASPAALIRDTVTSDCLTWYILGSTLTKTTTLSDPFLLSGDIFASLTRAETTSYISLPTTLLHILFRACELSNLVSVSTMLNDPNIDYSGILSQAHTLLQMTKSFDAHAWAFSLERSFDSSRTLSRIHTALAHQNALSTYICRSVDVIASPVALGENTETLVTNIITHLSFVGSTDPIFVATTWPTFIAGAETDNPIYRRWAVDRLSEFWSLMPWGYVRTAIEVMETTWRLRDEAGARGRAGGVLKRESWLQQLKELEKYWLIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>C8VPD2</accession>
    <name>C8VPD2_EMENI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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    <gene>
        <name evidence="2" type="ORF">ANIA_11314</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF85538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_050612861.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VPD2"/>
    <dbReference type="STRING" id="227321.C8VPD2"/>
    <dbReference type="GeneID" id="74896918"/>
    <dbReference type="KEGG" id="ani:ANIA_11314"/>
    <dbReference type="HOGENOM" id="CLU_2413251_0_0_1"/>
    <dbReference type="InParanoid" id="C8VPD2"/>
    <dbReference type="OMA" id="EHQTTNA"/>
    <dbReference type="OrthoDB" id="4504900at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF85538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="92" mass="9773" checksum="05624FF738353D02" modified="2009-11-03" version="1">MPTESQTTSRPAATQGGNEGLGHVDMDRPADTIYGFHSLKQQKNAAEDKYTSRAMGSAEQEPLEGDKEDTSFMNHKPGGAGTLPGYISSIGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>C8VQ64</accession>
    <name>C8VQ64_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_10035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
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            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF90094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050469317.1">
        <property type="nucleotide sequence ID" value="XM_050611048.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VQ64"/>
    <dbReference type="STRING" id="227321.C8VQ64"/>
    <dbReference type="GeneID" id="74896162"/>
    <dbReference type="KEGG" id="ani:ANIA_10035"/>
    <dbReference type="eggNOG" id="KOG1176">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_72_0_1"/>
    <dbReference type="InParanoid" id="C8VQ64"/>
    <dbReference type="OMA" id="IGIPSPM"/>
    <dbReference type="OrthoDB" id="10253869at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201:SF32">
        <property type="entry name" value="2-SUCCINYLBENZOATE--COA LIGASE, CHLOROPLASTIC_PEROXISOMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="1">
        <location>
            <begin position="72"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF90094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="575" mass="62012" checksum="F4FCB9F8BDE60F45" modified="2009-11-03" version="1">MSVSRSCFRPFLPAEIDGGHLPVDPSVFTHIERGLHQNPQGFAIQSTHQQPCHFSALVQTGSGTENGGAPNYDAVEREPGTCLAWTYTQLHHAALRIAAGLLARNAQPSTRMLLLIPNGAEFCLLLWTAVVLRVTIVCLDEELLNVEQHDELRRMLKTINPRVIVVQDVKGADVIDVALRNLPLDPDILKITLSELAGSQPDSAWRSLLSLSLTPALSASETESLLSSARWDSSNAARTYSILYTSGTSGVPKGCPLHISGMSYVLQSQSWLVNAENCTRALQQAHPCRGIAIAQTLQTWREGGTVVMTGNGFNAGDLVHAVKRHAVSFVVLTPAMVHPVADELKGRNGAADSVRTVQIGGDAVTRGALEICTRLFPKARVVVNHGMTEGGGAFVWPFNRPRDIPFYGEMSPVGSVARGAAVRIRGANATVARGELGELHVSCPSIIPGYLGGVSAQSFHDEDGRRWFKTGDVGLMDKQGVVFILGRMKDMINGKTCVVNAGGPFAVLARYTGKKEAQIRRHVVRALGKSNALNGVIYLHQLGLERFPVNGTHKIARGDVEGAMLAYLQTEPTSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>C8VQN3</accession>
    <name>C8VQN3_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Zn(II)2Cys6 transcription factor (Eurofung)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ANIA_00094</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF90212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050469338.1">
        <property type="nucleotide sequence ID" value="XM_050611072.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VQN3"/>
    <dbReference type="STRING" id="227321.C8VQN3"/>
    <dbReference type="GeneID" id="2875867"/>
    <dbReference type="KEGG" id="ani:ANIA_00094"/>
    <dbReference type="eggNOG" id="ENOG502SHED">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014802_0_0_1"/>
    <dbReference type="InParanoid" id="C8VQN3"/>
    <dbReference type="OMA" id="YAHTFAQ"/>
    <dbReference type="OrthoDB" id="10250282at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001216">
        <property type="term" value="F:DNA-binding transcription activator activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47431:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47431">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="30"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBF90212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="704" mass="78164" checksum="1835266201D1434A" modified="2009-11-03" version="1">MVYGTSAVPGTKSIDSKPRKKFAKPPVKVACLSCRASRTRCDGQDPCVNCQSKQRTCSYIPSKRGGPRPRKKKAFPVEATVHEDDVQKTITPLTPGLEDMATPVKLELNRHHHYHRPASHRHPWSGRMAVNMTCGLYFSSICDCADGGISLNAYYDFIHNYFPILPPRVGPAYIDSPLDCIEPYSESPEEPVIAYQPGSPLSLAISAILALIPHPNDPEPSSPRSVIRRRAYAHKFAQMANAGVESDCELHASPTNPFETTFKGRPRINRERFHPHTPVELESILALLLLTVYEYTQRGNLLKMRYRAGQALAIALDMSLHTLGEEYDEMAEARRRAWWMTYYCVLQGSIVSTTSLSIDANDSQFVTPYPRFAADPNVCFPARYLMRNSNWLSSQGWSIFIQSQQILVAATQFVIDVKKWIPTRTNMPYIVESMQRLDTWASALLARSSLPPSVAQSGNSSGISERITAQSIRTIARIKISRHCDLSKANACDDPVPECAAESPEHPNEISSVGCSCSSLDKFQQSSSSEYTRSTSTSSSASEFQPLLPQYSFISELPYTSQHSARVCLKASLLISHMFDSLPIPLPLSDSNNPPRVLQSLPRRQYPRTMPSFACCMMQGSYALLMIFYQANLVKSAQAEPGNSSSTSTSSSQDGYSLDSFTEELRQGLERLIGAASNYAISYEALTGMRDDIEGAYQTAFFQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C8VQV4</accession>
    <name>C8VQV4_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GAT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ANIA_00777</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF88804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_050613309.1"/>
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    <dbReference type="AlphaFoldDB" id="C8VQV4"/>
    <dbReference type="STRING" id="227321.C8VQV4"/>
    <dbReference type="GeneID" id="2876553"/>
    <dbReference type="KEGG" id="ani:ANIA_00777"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN0777"/>
    <dbReference type="eggNOG" id="ENOG502S1ZS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031989_0_0_1"/>
    <dbReference type="InParanoid" id="C8VQV4"/>
    <dbReference type="OMA" id="MMTLIET"/>
    <dbReference type="OrthoDB" id="5393057at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
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    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:ubiquitin binding"/>
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        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="GAT_GGA_Tom1-like"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="ENTH_VHS"/>
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    <dbReference type="InterPro" id="IPR004152">
        <property type="entry name" value="GAT_dom"/>
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    <dbReference type="InterPro" id="IPR038425">
        <property type="entry name" value="GAT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044836">
        <property type="entry name" value="TOL_plant"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45898:SF4">
        <property type="entry name" value="TARGET OF MYB PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45898">
        <property type="entry name" value="TOM1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03127">
        <property type="entry name" value="GAT"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89009">
        <property type="entry name" value="GAT-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50909">
        <property type="entry name" value="GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GAT" evidence="4">
        <location>
            <begin position="205"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="171"/>
            <end position="192"/>
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            <end position="379"/>
        </location>
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            <begin position="412"/>
            <end position="435"/>
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        <location>
            <begin position="1"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="302"/>
            <end position="316"/>
        </location>
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            <begin position="361"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="412"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="424"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50909"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CBF88804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="435" mass="48675" checksum="9FD002BA1CD103C6" modified="2009-11-03" version="1">MKRLLSNINKRPSTSRLRGGTEYPQDSPESVVLREVTAFCEKGQGPNQPQGDEFVHLPSIVESAESSPNAAREAAHLLRKLLSSPNSTAANIQYNALMLVRILIDNPGHTFSRNLDASFVTAIKDLLRSEKDVGVQRFLRETLDALEFQRGWDEDLKPLVEMWKKEKAKMSKTYTPKSRSNSWRATMSRQNSDIQVRPERVDTLPPPDELVSRISEAKTTAKLLIQFVQSTPPSEMLTNDLIQEFSARSRRAQRAISNYIHATNPAPDEDTLLTLIETNDELSVALSKHQRAMLQARKALGQQTPPAETATATQSPEHSDQSITGTSASRPVPPPPVPLRSQSPPLGEPVSPISPEATAHRSATTRTEQSDISVLSGTGPTARFEYRSEDYQVQNPFADNYSIPSTIPTHTYDEREIERDRWNKTQQPGQQHQHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>C8VSM4</accession>
    <name>C8VSM4_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_10102</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF89265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050469197.1">
        <property type="nucleotide sequence ID" value="XM_050613374.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VSM4"/>
    <dbReference type="GeneID" id="74896205"/>
    <dbReference type="KEGG" id="ani:ANIA_10102"/>
    <dbReference type="HOGENOM" id="CLU_2483349_0_0_1"/>
    <dbReference type="InParanoid" id="C8VSM4"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF89265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="87" mass="9685" checksum="4E464EFEAD59E8F2" modified="2009-11-03" version="1">MFGKSAGSISVFNQLALYGGNSTYKGKPLFRAAVMDSGHLPLQMQSNPTISPLCMSWTQMRALQPRQPRQPRQPRPSPSRLNTSRKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>C8VTZ2</accession>
    <name>C8VTZ2_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F-box domain protein (AFU_orthologue AFUA_1G02200)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_10073</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF89676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050469248.1">
        <property type="nucleotide sequence ID" value="XM_050610970.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VTZ2"/>
    <dbReference type="STRING" id="227321.C8VTZ2"/>
    <dbReference type="GeneID" id="74896190"/>
    <dbReference type="KEGG" id="ani:ANIA_10073"/>
    <dbReference type="eggNOG" id="ENOG502SR0E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066899_0_0_1"/>
    <dbReference type="InParanoid" id="C8VTZ2"/>
    <dbReference type="OMA" id="VYRLWLY"/>
    <dbReference type="OrthoDB" id="1638493at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="54"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF89676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="408" mass="47849" checksum="1BD908EE63CF3117" modified="2009-11-03" version="1">MASPSQYSPLWLQGTQKYLPDIIPSQLLMVMELFSVFAYPSGKESPSAMSFQYLVTELLLHIFRSCDTISDIINLAATCRRFRDVINRSNKLQILMDVAEMEFGPVDDIIQIATHNTSQPAHLFRTAPLTASLLKQIAQIGRAAQKWATIYPVKKWKLDYENRRSLTDEEQFRLRRAIYRLWLYHRAFHRREYDRYSRNLLNTVVERAQLLHNWTTSELADIEDIRTVIGDVVQNHICPSNGTIQRKFRKRYPESNYQLTFNIHLNYPISNTQTPYGFHDSSLNPTDHDQYFHLTHYTSFGNYSAKYRSRFRNDIFHEPGSEGWGDEIPHYYVVQDMMKLDPGQILWLRENCPLKEQVETFVLSLGDWFRDNGETFGDTLAWVIKERGEDLEEFRVAIVERELGIACN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>C8VUG4</accession>
    <name>C8VUG4_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Heme/steroid binding domain protein, putative (AFU_orthologue AFUA_1G16510)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ANIA_00954</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome b5 family. MAPR subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF88452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_658558.2">
        <property type="nucleotide sequence ID" value="XM_653466.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VUG4"/>
    <dbReference type="GeneID" id="2876731"/>
    <dbReference type="KEGG" id="ani:ANIA_00954"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN0954"/>
    <dbReference type="eggNOG" id="KOG1108">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070889_0_1_1"/>
    <dbReference type="InParanoid" id="C8VUG4"/>
    <dbReference type="OMA" id="ESFFWGM"/>
    <dbReference type="OrthoDB" id="10257697at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000018">
        <property type="entry name" value="Heme/steroid binding domain protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050577">
        <property type="entry name" value="MAPR/NEUFC/NENF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281:SF76">
        <property type="entry name" value="CALCUTTA CUP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281">
        <property type="entry name" value="MEMBRANE-ASSOCIATED PROGESTERONE RECEPTOR COMPONENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="3">
        <location>
            <begin position="88"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="220"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="171"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="220"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="238"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBF88452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="249" mass="28228" checksum="B14AAB43E1456F58" modified="2009-11-03" version="1">MMSEVRQRAGVPKDASRSTSTTKDRGNDAQSRTRSGISILDIFRVMVSLAVVSCGLSYYLTETVTWGYNPWFTNWSQLVRYVKGPIALTPSELSLYDGTNPDRPIYVAVNGTIFDVSANPRMYGPGGGYHFFAGRDATRAFVTGCFAEDLTDDLTGVEEMFIPIDEPEELEKLSSGEKKKRREQDMRNAKKRVEKQIAHWVGFFGKHQKYFEVGRVVKDDTEKDEMKGKRELCEAARKQRPKREKSKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>C8VUK2</accession>
    <name>C8VUK2_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ATP synthase subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">ANIA_00252</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="11">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) and CF(0) have multiple subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ATPase gamma chain family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF89876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050469282.1">
        <property type="nucleotide sequence ID" value="XM_050611008.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VUK2"/>
    <dbReference type="FunCoup" id="C8VUK2">
        <property type="interactions" value="926"/>
    </dbReference>
    <dbReference type="STRING" id="227321.C8VUK2"/>
    <dbReference type="GeneID" id="2876025"/>
    <dbReference type="KEGG" id="ani:ANIA_00252"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN0252"/>
    <dbReference type="eggNOG" id="KOG1531">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050669_4_1_1"/>
    <dbReference type="InParanoid" id="C8VUK2"/>
    <dbReference type="OMA" id="MQITSAM"/>
    <dbReference type="OrthoDB" id="239812at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd12151">
        <property type="entry name" value="F1-ATPase_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.80:FF:000001">
        <property type="entry name" value="ATP synthase gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1380.10:FF:000003">
        <property type="entry name" value="ATP synthase subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.80">
        <property type="entry name" value="ATP synthase, gamma subunit, helix hairpin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035968">
        <property type="entry name" value="ATP_synth_F1_ATPase_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000131">
        <property type="entry name" value="ATP_synth_F1_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023632">
        <property type="entry name" value="ATP_synth_F1_gsu_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01146">
        <property type="entry name" value="ATPsyn_F1gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11693">
        <property type="entry name" value="ATP SYNTHASE GAMMA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11693:SF22">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT GAMMA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00231">
        <property type="entry name" value="ATP-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039089">
        <property type="entry name" value="ATP_synthase_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00126">
        <property type="entry name" value="ATPASEGAMMA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52943">
        <property type="entry name" value="ATP synthase (F1-ATPase), gamma subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00153">
        <property type="entry name" value="ATPASE_GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="9 11" id="KW-0139">CF(1)</keyword>
    <keyword evidence="4 11" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="6 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CBF89876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="296" mass="31966" checksum="C99F4EC874F0D8C5" modified="2009-11-03" version="1">MLTRAVRPAVRAGAAAVTRTAPPNAANFATLREIEGRLKSIKNIKKITNTMKVIASTRLTRAQKAMDDSRAYGQTSNTLFEQAETKALEDKKTLLVVASSDKGLCGGIHSGLSKAARRALEANPNSDLVVLGEKAKAQLSRTNPNAIVLSFANVCKDIPTFADAQAVADQIALLPTDYASVKVIYNKFVNAQSYEPDTVEAYSEEAITQSPNFSAYEADEETLSNLREYALANSLFWAMAEGHACEISARRNAMENASKNAGEMIDKFQILYNRQRQAAITGELVEIITGAAASAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-12-14" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>G5EB29</accession>
    <accession>C8VSS6</accession>
    <name>G5EB29_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ANIA_01216</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF87918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_658820.1">
        <property type="nucleotide sequence ID" value="XM_653728.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G5EB29"/>
    <dbReference type="FunCoup" id="G5EB29">
        <property type="interactions" value="382"/>
    </dbReference>
    <dbReference type="STRING" id="227321.G5EB29"/>
    <dbReference type="GeneID" id="2876988"/>
    <dbReference type="KEGG" id="ani:ANIA_01216"/>
    <dbReference type="eggNOG" id="KOG2914">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045011_13_4_1"/>
    <dbReference type="InParanoid" id="G5EB29"/>
    <dbReference type="OMA" id="QVHTFDG"/>
    <dbReference type="OrthoDB" id="40579at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050308">
        <property type="term" value="F:sugar-phosphatase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd07527">
        <property type="entry name" value="HAD_ScGPP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.240:FF:000013">
        <property type="entry name" value="Glycerol-3-phosphate phosphatase (GppA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051806">
        <property type="entry name" value="HAD-like_SPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43481">
        <property type="entry name" value="FRUCTOSE-1-PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43481:SF4">
        <property type="entry name" value="GLYCEROL-1-PHOSPHATE PHOSPHOHYDROLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01135">
        <property type="entry name" value="C1.5.6:_HAD__Beta-PGM__Phospha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF87918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="236" mass="25130" checksum="6083DBD969966B82" modified="2011-12-14" version="1">MAATGSFSAPPQVLTFDGLLSDFDGTIVDSTDAIVKHWHKIGAELGVDPKTILATSHGRRSIDTLQLYDPAKANWEYVSYIEGLIPKEYGSDAIEIPGARSILAALEETGATWGVVTSGTRALIDGWLGVLKLTHPDVLVVAEDVELGKPDPRCYLLGRKKMGLEHSSSIVVLEDAPSGIKAGKAAGFTVIALTTTHTLEQLQAAGADVIVEDLRSISVKGVVDGRVQLEVRNAFQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1990-08-01" modified="2025-02-05" version="150" xmlns="https://uniprot.org/uniprot">
    <accession>P17489</accession>
    <accession>C8V1C0</accession>
    <accession>Q5AYJ5</accession>
    <name>LAC1_EMENI</name>
    <protein>
        <recommendedName>
            <fullName>Laccase-1</fullName>
            <ecNumber evidence="2">1.10.3.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Benzenediol:oxygen oxidoreductase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Conidial laccase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Diphenol oxidase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Laccase I</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Urishiol oxidase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">yA</name>
        <name type="ORF">AN6635</name>
    </gene>
    <organism>
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1990" name="Nucleic Acids Res." volume="18" first="3415" last="3415">
            <title>Sequence and molecular structure of the Aspergillus nidulans yA (laccase I) gene.</title>
            <authorList>
                <person name="Aramayo R."/>
                <person name="Timberlake W.E."/>
            </authorList>
            <dbReference type="PubMed" id="2192364"/>
            <dbReference type="DOI" id="10.1093/nar/18.11.3415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
            <strain>Winter</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="1989" name="Genetics" volume="121" first="249" last="254">
            <title>Molecular characterization of the Aspergillus nidulans yA locus.</title>
            <authorList>
                <person name="O'Hara E.B."/>
                <person name="Timberlake W.E."/>
            </authorList>
            <dbReference type="PubMed" id="2659435"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Required for the conversion of the yellow polyketide pigment synthesized by wA to the conidial green pigment.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>4 hydroquinone + O2 = 4 benzosemiquinone + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11276"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17594"/>
            <dbReference type="ChEBI" id="CHEBI:17977"/>
            <dbReference type="EC" id="1.10.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="2">Binds 4 Cu cations per monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="developmental stage">
        <text evidence="4">Specifically expressed late during asexual development.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the multicopper oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.10.3.2" evidence="2"/>
    <dbReference type="EMBL" id="X52552">
        <property type="protein sequence ID" value="CAA36787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AACD01000110">
        <property type="protein sequence ID" value="EAA58164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF71142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="S10149">
        <property type="entry name" value="KSASL1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_664239.1">
        <property type="nucleotide sequence ID" value="XM_659147.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P17489"/>
    <dbReference type="SMR" id="P17489"/>
    <dbReference type="STRING" id="227321.P17489"/>
    <dbReference type="GlyCosmos" id="P17489">
        <property type="glycosylation" value="7 sites, No reported glycans"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CBF71142">
        <property type="protein sequence ID" value="CBF71142"/>
        <property type="gene ID" value="ANIA_06635"/>
    </dbReference>
    <dbReference type="GeneID" id="2870381"/>
    <dbReference type="KEGG" id="ani:ANIA_06635"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN6635"/>
    <dbReference type="eggNOG" id="KOG1263">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006504_5_0_1"/>
    <dbReference type="InParanoid" id="P17489"/>
    <dbReference type="OMA" id="SLLHCHI"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052716">
        <property type="term" value="F:hydroquinone:oxygen oxidoreductase activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048315">
        <property type="term" value="P:conidium formation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043324">
        <property type="term" value="P:pigment metabolic process involved in developmental pigmentation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13850">
        <property type="entry name" value="CuRO_1_Abr2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13876">
        <property type="entry name" value="CuRO_2_Abr2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13898">
        <property type="entry name" value="CuRO_3_Abr2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000036">
        <property type="entry name" value="L-ascorbate oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF488">
        <property type="entry name" value="LACCASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-0183">Conidiation</keyword>
    <keyword id="KW-0186">Copper</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <keyword id="KW-0749">Sporulation</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000002927" description="Laccase-1">
        <location>
            <begin position="21"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like 1">
        <location>
            <begin position="45"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like 2">
        <location>
            <begin position="270"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like 3">
        <location>
            <begin position="463"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="binding site" description="type 2 copper site" evidence="1">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="type 3 copper site" evidence="1">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" description="type 3 copper site" evidence="1">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" description="type 3 copper site" evidence="1">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" description="type 1 copper site" evidence="1">
        <location>
            <position position="508"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
            <label>4</label>
        </ligand>
    </feature>
    <feature type="binding site" description="type 2 copper site" evidence="1">
        <location>
            <position position="511"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="type 3 copper site" evidence="1">
        <location>
            <position position="513"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" description="type 3 copper site" evidence="1">
        <location>
            <position position="585"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" description="type 1 copper site" evidence="1">
        <location>
            <position position="586"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
            <label>4</label>
        </ligand>
    </feature>
    <feature type="binding site" description="type 3 copper site" evidence="1">
        <location>
            <position position="587"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" description="type 1 copper site" evidence="1">
        <location>
            <position position="591"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
            <label>4</label>
        </ligand>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="75"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="257"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="403"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="443"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="486"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="531"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="546"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; CAA36787." evidence="5" ref="1">
        <original>DGLTA</original>
        <variation>TALLS</variation>
        <location>
            <begin position="225"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; CAA36787." evidence="5" ref="1">
        <original>G</original>
        <variation>A</variation>
        <location>
            <position position="359"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; CAA36787." evidence="5" ref="1">
        <original>G</original>
        <variation>A</variation>
        <location>
            <position position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="D0VWU3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="Q70KY3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3"/>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="2659435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <sequence length="609" mass="67981" checksum="529A20B2DD9AA73E" modified="2009-05-26" version="3" precursor="true">MYLSTVLFPLLALNLGLSHARFVRETLELTWEYGSPNGGTPREMVFTNGEYPGPDLIFDEDDDVEVLVINNLPFNTTVHWHGLEMRETPEADGVPGLTQTPIEPGATFTYRFRAYPAGTFWYHSHYKGLMQDGQVGAMYIRRKPDALRPYAVITEDPRELAEIQYAEDNPYLMLATDWTYLTSAEYHNIEVESGYNVFCVDSLLINGRGSVYCPGYQYLEEVSDDGLTAVLEGTHLTEKGCLQPDLHNVQGDYGPWNLSAVPTEVVFNCTPSSVEPPVIYVDPEFNGWVSLNFIGGAAQKAITFSVDNHPMWVYEVDGQFVEPREVEMVGVYSGARYAVMIKLDQTPGDYAIRIAVNGGDQVMSVYAILSYVNQDWIHRENVPKAAIGPHTDTVGYMNYGGGNTSADVRQLLFTENLPAFGVPPPPPSSEVSTTLRTGMIRVNNSYSWSLGNNVLYEPEMTSSTPLLFEPDPLAVIAPKYALTTENNTWVDIVLEITADPRDLIHPPHPIHKHGNRAYIIGNGVGKFRWENVSAAEAEVPDLFYVNETAALRDTFVTDFFDSRLMDGAWIVIRYFVQDKFPSILHCHIASHQMGGMALALLDGVDVWDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="111" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AR01</accession>
    <accession>C8VQC9</accession>
    <name>Q5AR01_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Hypothetical pyrroline-5-carboxylate reductase (Eurofung)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ANIA_09279</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pyrroline-5-carboxylate reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF87319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_682548.1">
        <property type="nucleotide sequence ID" value="XM_677456.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AR01"/>
    <dbReference type="STRING" id="227321.Q5AR01"/>
    <dbReference type="GeneID" id="2867865"/>
    <dbReference type="KEGG" id="ani:ANIA_09279"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN9279"/>
    <dbReference type="eggNOG" id="KOG3124">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042344_1_1_1"/>
    <dbReference type="InParanoid" id="Q5AR01"/>
    <dbReference type="OMA" id="HYLDMAT"/>
    <dbReference type="OrthoDB" id="10263291at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004735">
        <property type="term" value="F:pyrroline-5-carboxylate reductase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3730.10:FF:000001">
        <property type="entry name" value="Pyrroline-5-carboxylate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3730.10">
        <property type="entry name" value="ProC C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01925">
        <property type="entry name" value="P5C_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029036">
        <property type="entry name" value="P5CR_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000304">
        <property type="entry name" value="Pyrroline-COOH_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645:SF65">
        <property type="entry name" value="HYPOTHETICAL PYRROLINE-5-CARBOXYLATE REDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645">
        <property type="entry name" value="PYRROLINE-5-CARBOXYLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14748">
        <property type="entry name" value="P5CR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000193">
        <property type="entry name" value="Pyrrol-5-carb_rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyrroline-5-carboxylate reductase catalytic N-terminal" evidence="5">
        <location>
            <begin position="8"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="Pyrroline-5-carboxylate reductase dimerisation" evidence="6">
        <location>
            <begin position="183"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="12"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>NADPH</name>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="84"/>
            <end position="87"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000193-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBF87319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="289" mass="30129" checksum="372B1B0EA99076D8" modified="2005-04-26" version="1">MGIDIDLTVAVIGCGTLGTAIAAGILDPKDKSGINIKRLIATVGTEPSKQRVRDALSTHESRLTVLTHGGNVRAIQEADVVLLAVKPFKRAEVFCAPGFKEAIRNKLVLSIMAGITTKEFARLAIGDGAAPGILQVVRAMPNMAAKIREAMTLYTPSPGTSPENLSIASWIFGQVGESHQIPEASFDICAVLVGCAGSLLLLAVDGLLDAAVAEGVRRSEVQNLVVNSAIGMLKLVPAGDHPSVLREKIASPGGCSIQALLELERLGARSAFTRAIMAAAEKSKAMSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="113" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ARR7</accession>
    <accession>C8VKY8</accession>
    <name>Q5ARR7_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Zn(II)2Cys6 transcription factor, putative (Eurofung)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ANIA_09013</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF84461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_682282.1">
        <property type="nucleotide sequence ID" value="XM_677190.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ARR7"/>
    <dbReference type="FunCoup" id="Q5ARR7">
        <property type="interactions" value="263"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5ARR7"/>
    <dbReference type="GeneID" id="2868259"/>
    <dbReference type="KEGG" id="ani:ANIA_09013"/>
    <dbReference type="eggNOG" id="ENOG502R94Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009030_0_1_1"/>
    <dbReference type="InParanoid" id="Q5ARR7"/>
    <dbReference type="OMA" id="ARCYMID"/>
    <dbReference type="OrthoDB" id="5089701at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050675">
        <property type="entry name" value="OAF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069">
        <property type="entry name" value="OLEATE-ACTIVATED TRANSCRIPTION FACTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069:SF25">
        <property type="entry name" value="TRANSCRIPTION FACTOR, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="118"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBF84461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="679" mass="76307" checksum="A3D5B12127C6E880" modified="2005-04-26" version="1">MPRPRRSHTLGACRTCRRRHVKCDQKRPACGTCRTLGVPCEGFANEVRWMRDGSDDGDDGSKAEEQQGARRHLYTEQLRQSMSTSLGSNLVSGSISASLAEIDLKTRDAEHPGGDIVIGPFGVLDFGSTQPQEKKQDSQKMTPKQLEPSREAPHSPPQTASTAGQEIQELPTLVNDSPSYIDDFLHWSDILGLSPEQPGFFQPSMLDLDTYLADPIPESFDVDMNVETRAGPRSMAIPTPPSSAMEMASTFLDAAALADAPYLFKHFNENVVPQMMIMPLGDKSPWRILNLSAAMATYNELTILGSQSISHARLANLYALLACSAAHLSISHGSTVSTGSTHWQQASGQMFEQARDHMQKSLKLETREPKRAKYKDQLMAICCLIQYTVISGQQQHGRSFMVNAEYILRMRGLLKHRISQKSRLLHHVYTWLRLVGESTYVLHDYNPSSTFIEALKSNFQRPRVDPIVDSSPELNPRLDDFLRLEAHDADSDLNINEPKDEQTGLHDIHLQDSRSFSNTLYKQVYGIPETWLSLLSQTTRLANVMETFRIAQQACGNTSLDAWETLHRRSVRLENLICSCDLSLVRDAFRPHDHMLRALNAALVIFFYRRIRRLPCRLNIALDLELHGRRLLQVAKPSHLSGERRFWHGLTMPSQTAALPVSAPREISWSTCGISRTSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ASU0</accession>
    <accession>C8VAC9</accession>
    <name>Q5ASU0_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conidiation protein Con-6, putative (AFU_orthologue AFUA_4G03615)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_08640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF78277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_681909.1">
        <property type="nucleotide sequence ID" value="XM_676817.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ASU0"/>
    <dbReference type="GeneID" id="2868580"/>
    <dbReference type="KEGG" id="ani:ANIA_08640"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN8640"/>
    <dbReference type="eggNOG" id="ENOG502S75W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107705_1_0_1"/>
    <dbReference type="InParanoid" id="Q5ASU0"/>
    <dbReference type="OMA" id="MEHRTEQ"/>
    <dbReference type="OrthoDB" id="5419162at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018824">
        <property type="entry name" value="Conidiation-specific_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052670">
        <property type="entry name" value="UPF0654_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36576:SF2">
        <property type="entry name" value="PROTEIN CON-6, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G03615)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36576">
        <property type="entry name" value="UPF0654 PROTEIN C11D3.01C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10346">
        <property type="entry name" value="Con-6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF78277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="91" mass="10029" checksum="99FC656F40CFCF54" modified="2005-04-26" version="1">MADERINQMRGYKATLNNPRVSNEAKEHAQSVLDNELGGDQPHEDILTAQGARNKSPNRVAGGYKAAMHNDSISKQGKKQAQEKLGEMPQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="136" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ASZ9</accession>
    <accession>C8VAJ4</accession>
    <name>Q5ASZ9_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">L-ascorbate oxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ANIA_08581</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF78399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_681850.1">
        <property type="nucleotide sequence ID" value="XM_676758.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ASZ9"/>
    <dbReference type="STRING" id="227321.Q5ASZ9"/>
    <dbReference type="GeneID" id="2868491"/>
    <dbReference type="KEGG" id="ani:ANIA_08581"/>
    <dbReference type="eggNOG" id="KOG1263">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006504_8_3_1"/>
    <dbReference type="InParanoid" id="Q5ASZ9"/>
    <dbReference type="OMA" id="QVANNFT"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd13847">
        <property type="entry name" value="CuRO_1_AAO_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017762">
        <property type="entry name" value="Multicopper_oxidase_fun"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03390">
        <property type="entry name" value="ascorbOXfungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF394">
        <property type="entry name" value="FI03373P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030175715" description="L-ascorbate oxidase" evidence="5">
        <location>
            <begin position="18"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="8">
        <location>
            <begin position="34"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="6">
        <location>
            <begin position="159"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="7">
        <location>
            <begin position="390"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBF78399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="673" mass="75822" checksum="683B1DDAD70F2C95" modified="2005-04-26" version="1">MHRMLFVCGLFLLSVQGLLIRHDGSFQPDHILRVNSKNYMQACSPRYSVLVNGSFPGPEIRVQEGQTSWIRVYNDMENLNVTMHWHGLTAITAPFSDGTPMASQWPIPPGHFFDYEVKVEPGYAGTYFYHSHVGFQAVTAAGPLIVESTKPPPYFYDEERIIALSDFFSKTDKEIEHGLMSSQFQWSGETEAVLVNGHSLSPSPMNGTGSCRREVLQVEPGKTYRLRIIGATALSFISFVIESHDVEIIEADGHYTQKLKTHNLQIAGGQRYSVLLKAKDNAALEQLSQRHFIIQITTLARPTTLTTYAILQYPSNAPASLTNVSATPLMPVPSIAYGWLDYQLQPLERDPDFLTSDSVTRRIVIDVHQNFSDHVLWLQSGYDWVETFPETPYLVQIQRGELNVTESLQKAISAGNNFDKDYRIFPAQLGEVLEIVWQNRGAVGNSTVRNRGVETHPFHGHGRHFYDIGGGDGEYNAAENEKRLQETQPVLRDTTVLYGYSREVAPGAPSGWRAWRIRVTNPGVWMMHCHTLQHMIMGMQTVFVFGDQDDMKENMGTYNSGYLTYGGSAYGNETFFPETFCMILHNGVQDAVIVFQRPEEDGDNLAMSEVLDGPLLEKYIELIKQQYGVRFFRKALSGFWTLSAIASGVNVLQVPGLSMKSIMEVFCVDYHHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="101" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AT34</accession>
    <accession>C8VER5</accession>
    <name>Q5AT34_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phosphatidylglycerol specific phospholipase, putative (AFU_orthologue AFUA_3G01530)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ANIA_08546</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF80772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_681815.1">
        <property type="nucleotide sequence ID" value="XM_676723.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AT34"/>
    <dbReference type="STRING" id="227321.Q5AT34"/>
    <dbReference type="GeneID" id="2868882"/>
    <dbReference type="KEGG" id="ani:ANIA_08546"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN8546"/>
    <dbReference type="eggNOG" id="ENOG502QPJ0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029943_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AT34"/>
    <dbReference type="OMA" id="ECCSYMS"/>
    <dbReference type="OrthoDB" id="5135119at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042578">
        <property type="term" value="F:phosphoric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009395">
        <property type="term" value="P:phospholipid catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000052">
        <property type="entry name" value="Phosphatidylglycerol specific phospholipase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000107">
        <property type="entry name" value="Phosphatidylglycerol specific phospholipase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007312">
        <property type="entry name" value="Phosphoesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31956:SF1">
        <property type="entry name" value="NON-SPECIFIC PHOSPHOLIPASE C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31956">
        <property type="entry name" value="NON-SPECIFIC PHOSPHOLIPASE C4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04185">
        <property type="entry name" value="Phosphoesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBF80772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="508" mass="56044" checksum="FFEE06C4F82DD2C9" modified="2005-04-26" version="1">MNWLRGASDPPRPASPADSEEPLLNDDDRSHRSSQDEEATQNDVKRSPRSRTRVVTLFILLTSSITTVAVVIYLLVAHRLPAPTGPLHHHDSNTPIKNVVVLVQENLSFDTLAGGLNYSRDIDNIVNLPPNKRFCNPSNVADPSSPLICAKPLAKNVAPDDPDHSIAGGNFQVYGTDHPDLSIHKPTMQGFVSEQIRSHGINGDLKRAAEVINYYAPEHIPVFNALAENYLLLDRWFASVPGPTNPNRAYLTSGTSHGHGWNDPSFDHSSLPQVSIFQQLTEANISWINYSNATGFAPDALFYTWTAKSEAGRNSIKSIDQFYSDAAAGNLPQFTWINPECCSYTSFHPPSPTNLGEGFVKSVYEALRAGPQWNETLFILTFDEHGGFADHVPPPEKVPPGDGIPYTEVAKDGKPTTFHFDRLGIRVPTLLISPYVQKGAVVHGPKGKGKKGQAKGEYTHTSILKYVDELWGLDILTPRVEWSASFGDLIEKKFREDTPELLPEPVIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="143" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ATN6</accession>
    <accession>C8VE37</accession>
    <name>Q5ATN6_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">ABC multidrug transporter (Eurofung)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">ANIA_08344</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF80350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_681613.1">
        <property type="nucleotide sequence ID" value="XM_676521.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q5ATN6">
        <property type="interactions" value="367"/>
    </dbReference>
    <dbReference type="GeneID" id="2868759"/>
    <dbReference type="KEGG" id="ani:ANIA_08344"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN8344"/>
    <dbReference type="eggNOG" id="KOG0065">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_35_0_1"/>
    <dbReference type="InParanoid" id="Q5ATN6"/>
    <dbReference type="OMA" id="KTLRTQC"/>
    <dbReference type="OrthoDB" id="245989at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03233">
        <property type="entry name" value="ABCG_PDR_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03232">
        <property type="entry name" value="ABCG_PDR_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003632">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000054">
        <property type="entry name" value="ABC multidrug transporter atrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029481">
        <property type="entry name" value="ABC_trans_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034001">
        <property type="entry name" value="ABCG_PDR_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034003">
        <property type="entry name" value="ABCG_PDR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010929">
        <property type="entry name" value="PDR_CDR_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14510">
        <property type="entry name" value="ABC_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06422">
        <property type="entry name" value="PDR_CDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="487"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="522"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="555"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="596"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="631"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="736"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1160"/>
            <end position="1179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1191"/>
            <end position="1214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1235"/>
            <end position="1260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1280"/>
            <end position="1303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1315"/>
            <end position="1339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1436"/>
            <end position="1454"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="123"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="820"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CBF80350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="1462" mass="164353" checksum="00A2D0CB911D4CB2" modified="2005-04-26" version="1">MDPITDSRPKAVDRDSTATSCNSTLDENQIENDREVTNLARVLSERSKHSHHQLPFNFGKDPSLDPQNAQFNARAWAKAFYNVRYSSTDAPPPRVAGVAFKNLNVAGYGSPVDYQMSVGNALLKLPTLAWQWLGGKKQRTEILQDVDGLLLPGEQLCVLGPPGSGCSTLLKTIAQETHGFEVDPSSYVNYQGITPKQMSKKFRGEAIYTAEVDAHFPQLVVGDTLYFAALARTPRHVPGGMSREEYAVHLRDVIMSTFGISHTINTKVGNDFVRGVSGGERKRVTIAEAALSYAPLQCWDNSTRGLDSANAVEFCKTLRTQGDVFGITSCVAIYQAPQAAYELFDKVTVLYEGRQIYFGPAKEAKDYFIRLGFVCPEAQTTPDFLTSMSSPVERVIRPGFENLVPRTADDFAQRWKESPERQALLRDIDRYNTEHPFNATDLDLFSSSRDAEKSKNQRPKSPYTLSYWGQIRICLWRDFQRLKNDPSVTLAMLILNFFEALIISSVFYNLPGNTSSFFSRGALLFMMVLLSAFSSVLEIITLYEKRTIVEKHSRYALYHPSAEAISSMIMDMPYKIVNSLLNSLVLYFMGNLRREAGAFFFLYLISFAMMMGMSMFFRFFASLTKSIEQALAPSSIILLALVLYTGFAIPVSYMRGWASWIRWLNPVSYGFEAVMVNEFNGREFPCVSFVPSGPGYENVSPQERVCSTVGAVPGSDVVQGADFVRSSYGYEYSHRWRNFGIIVALTVFLTMCHLVTSELVSSQRSKGEVLVFRRGKAQKMREKRHHTDEEQIAAPAAQNEKVIQEEPGLVSGVEQQSSIFHWEDVTYDIKIKGETRRILDRVDGWIRPGTLTALMGVSGAGKTTLLDVLASRTTIGVVGGNMLVDGRSRDESFQRKTGYVQQQDLHLHTSTVREALKFSALLRQPPQYSRAERLAYVETVIDLLNMREYADAIVGVPGEGLNVEQRKRLTIGVELAARPKLLLFLDEPTSGLDSQTSWSICNLMETLTKNGQAILCTIHQPSAMLFQRFDRLLLLAKGGKTVYFGEVGQGARTLMDYFVRNGGSACPPGANPAEHMLEVIGAAPGAQTDIDWPEVWRSSPEYQQVRSELARLRELANRPSPVSDPNDKSSYAEFAAPFSEQLLQVGRRVFQQYWRSPSYIYSKALLTVGCSLFIGFSFFKADNTRQGLQNQMFGVFVFLFVVVQLVMQVIPSFVTQRTLYESRERQSKTYAWQAFVLSNIIVEFVWNTIMAIFCYLVWFYPVGLYQNARYTDTIHSRSTLTLLIIWAVFLFASSFAHMLIAGVDSAEMASALSNIFFIMMYAFCGILAGPNALPGFWIFMYRVNPLTYLVSSLLSATLGDAPMHCANNEVLTFFAPPGLTCREYMEDYRSVNGGYLLNPDAQGSDQCQFCSLEYTNQYLSSLSIDFNNRWRDFGLLWVYVIVNTVGAIVFYKLFRVPRAKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="109" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AUH2</accession>
    <accession>C8V673</accession>
    <name>Q5AUH2_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sulfite oxidase, putative (AFU_orthologue AFUA_5G02190)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ANIA_08058</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF73801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_681327.1">
        <property type="nucleotide sequence ID" value="XM_676235.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AUH2"/>
    <dbReference type="STRING" id="227321.Q5AUH2"/>
    <dbReference type="GeneID" id="2869209"/>
    <dbReference type="KEGG" id="ani:ANIA_08058"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN8058"/>
    <dbReference type="eggNOG" id="KOG0535">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003827_5_2_1"/>
    <dbReference type="InParanoid" id="Q5AUH2"/>
    <dbReference type="OMA" id="TWHVAEL"/>
    <dbReference type="OrthoDB" id="432685at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008482">
        <property type="term" value="F:sulfite oxidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006790">
        <property type="term" value="P:sulfur compound metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd02111">
        <property type="entry name" value="eukary_SO_Moco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.420.10:FF:000002">
        <property type="entry name" value="sulfite oxidase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.650:FF:000005">
        <property type="entry name" value="Sulfite oxidase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.420.10">
        <property type="entry name" value="Oxidoreductase, molybdopterin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005066">
        <property type="entry name" value="MoCF_OxRdtse_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008335">
        <property type="entry name" value="Mopterin_OxRdtase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000572">
        <property type="entry name" value="OxRdtase_Mopterin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036374">
        <property type="entry name" value="OxRdtase_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19372:SF7">
        <property type="entry name" value="SULFITE OXIDASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19372">
        <property type="entry name" value="SULFITE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03404">
        <property type="entry name" value="Mo-co_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00174">
        <property type="entry name" value="Oxidored_molyb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00407">
        <property type="entry name" value="EUMOPTERIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56524">
        <property type="entry name" value="Oxidoreductase molybdopterin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidoreductase molybdopterin-binding" evidence="5">
        <location>
            <begin position="39"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="Moybdenum cofactor oxidoreductase dimerisation" evidence="6">
        <location>
            <begin position="246"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBF73801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="380" mass="42491" checksum="9760A6780856363F" modified="2005-04-26" version="1">MVATHIEYTKENPLNREPPVRELVSSFITPSSTSYDRNHGPIPHLSADTHTIEVDGLVKTPLRLSVHQLATEFPQHEVLCALECAGNRRHTMRTMLKEVDGIDWGDAAIMNCKWRGPRLRDVLHRAGVDQCKGRPGLHVAFSSFQVQCEEDEWFGGSVELERGLDEEADVILALEMNDAPLEPRHGFPVRVVLPGIAGARWVKWLDRITVQDQESTNFYQRRDYKVLPEEAVNRDAAEPFWDQTPAISEISINSVVAVPEDNETVYLSDVGKLEVKGYAVPQGSGGPVVKVQVSGDGGRTWIDAEIGKSESAGADGRVRKWCWVLWRVEVEVETGEGKEVISRAIDAQGNMQAEHSQWNLRGVGYSGYGRAKNLTVRYRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="132" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AUP4</accession>
    <accession>C8V5K7</accession>
    <name>Q5AUP4_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein kinase, putative (AFU_orthologue AFUA_6G03252)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ANIA_07986</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF73654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_681255.1">
        <property type="nucleotide sequence ID" value="XM_676163.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AUP4"/>
    <dbReference type="STRING" id="227321.Q5AUP4"/>
    <dbReference type="GeneID" id="2869119"/>
    <dbReference type="KEGG" id="ani:ANIA_07986"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN7986"/>
    <dbReference type="eggNOG" id="KOG0197">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003888_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AUP4"/>
    <dbReference type="OMA" id="MEEAICY"/>
    <dbReference type="OrthoDB" id="626167at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="64"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="828"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1019"/>
            <end position="1051"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBF73654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="1212" mass="134093" checksum="82DAF02F816A365B" modified="2005-04-26" version="1">MATSTYLSTRSAYGTRYSTSTSGAPESYEIRKDHYDLFLLIQDLVRGIDGFMLEFPVDDWGQQQSIKITLGSGGFSSVQRRIAKGRWGNRSVMAYKSIRPRFDQDGRFDDQDALEQAVVELRLLSASGIRSHRHITQLRGISFETPHHRTDGYLAPVLMFDASSMGNLLDFIRDPVRMVDGPYWEFCLDVARGLQALHGHGFIHGDVKCENVLIFPARTPQGRSLIAKVTDFGCSMVIDEVGSQTRLRGSTIPYDAPEADNVIERGNLVFTDVYSFGLLVWRVLIDGADPFKHSRYATMNATVERYNYSLIREDKRNGTALSLALDRAMDPDSGLSPEIANVLGEVLSIALNPEPQKRDLGRIMEVLDRPENLQKRLFGLVPSNAQFLREFTKFEIDRFVGHAQASRGLAQWESVPAKADQAYHIVRKYGILNSDFRGFGMSRLSPVSGALRDLLLTTENLYRTHGQPIPALHFPKLPASNDPARNPEAVWQSLMHTIYLISKDAGAMVTSVGKEMNSLLERAPNPRRDGRFGAVQGLFDFPGGLAAADTMAMMSEDIVPMAASQDARPTQLFTDIALRARRLVVQADRCLAAIEEAICHCIGFGVKQDHSRYLAIMKECCEAGYQPAQAALSQIRHALGLPLGDGVHPYPISHGGELPLPESVTSFPYSTDLHRAVVQRNQTALIDLIRNGASSMGTAGPAIFHKQHSFALDAVQLACSYHDAEMLEILLDAAPFYPINVDGNTSLGLLYFAIQCQNTHLRMARYGIDTYFQLEKTMQLLLRRGSANIVDKDGMTALHLAAACDMPEILEYVLTVDALTQDINTELDGKTPLDIAIFKGRPAAFDLLVAAGAQVSRSSLTGHALNIPVQVTPSNDYFLKKTLELGAQTLTPNDKHTALKRALQLQQWAIADFLMSQGANINGLTMNPSQTFIRFTVFGDVLSSWNLGDTLAVLDRLMSLAAKHNQEPQFIVSPSLHSSALHIVAGQLSAMTQEEVARIYPLLLAKFPSKDQLEARDYRGWTALHLAVSVRNVVAVRALLDAGADINSMALVEGYPAGPSPKDMAFGQFFSRASFLDFEPNSRDRADRALEQLIKLFTSERYSKLAKRSVTLRAEQRPSVTAQPRQVMDYVDELAQRSRPLHPQHSVSLTDQVVQAVAGGDNQKAVQMYQKTGHENVGKSIEWAGIECVRFLQHEGAGLLRDMGLLDDYLSD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-07-27" modified="2026-01-28" version="123" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AVF0</accession>
    <accession>C8VDJ5</accession>
    <name>AMPP1_EMENI</name>
    <protein>
        <recommendedName>
            <fullName>Probable Xaa-Pro aminopeptidase P</fullName>
            <shortName>AMPP</shortName>
            <shortName>Aminopeptidase P</shortName>
            <ecNumber>3.4.11.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Aminoacylproline aminopeptidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Prolidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">ampp</name>
        <name type="ORF">AN11005</name>
    </gene>
    <organism>
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>Release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide.</text>
            <dbReference type="EC" id="3.4.11.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="1">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M24B family.</text>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="erroneous gene model prediction">
            <sequence resource="EMBL-CDS" id="EAA61245" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EC" id="3.4.11.9"/>
    <dbReference type="EMBL" id="AACD01000131">
        <property type="protein sequence ID" value="EAA61245.1"/>
        <property type="status" value="ALT_SEQ"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF79990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AVF0"/>
    <dbReference type="SMR" id="Q5AVF0"/>
    <dbReference type="FunCoup" id="Q5AVF0">
        <property type="interactions" value="370"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5AVF0"/>
    <dbReference type="MEROPS" id="M24.009"/>
    <dbReference type="EnsemblFungi" id="CBF79990">
        <property type="protein sequence ID" value="CBF79990"/>
        <property type="gene ID" value="ANIA_11005"/>
    </dbReference>
    <dbReference type="GeneID" id="2869597"/>
    <dbReference type="KEGG" id="ani:ANIA_11005"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN11005"/>
    <dbReference type="eggNOG" id="KOG2413">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002492_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AVF0"/>
    <dbReference type="OMA" id="EPGMILS"/>
    <dbReference type="OrthoDB" id="9995434at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01085">
        <property type="entry name" value="APP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.350.10:FF:000010">
        <property type="entry name" value="Probable Xaa-Pro aminopeptidase P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.230.10:FF:000007">
        <property type="entry name" value="Xaa-Pro aminopeptidase P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.350.10:FF:000003">
        <property type="entry name" value="Xaa-pro aminopeptidase P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000587">
        <property type="entry name" value="Creatinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033740">
        <property type="entry name" value="Pept_M24B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032416">
        <property type="entry name" value="Peptidase_M24_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001131">
        <property type="entry name" value="Peptidase_M24B_aminopep-P_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050422">
        <property type="entry name" value="X-Pro_aminopeptidase_P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43763">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43763:SF6">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01321">
        <property type="entry name" value="Creatinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16189">
        <property type="entry name" value="Creatinase_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16188">
        <property type="entry name" value="Peptidase_M24_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00491">
        <property type="entry name" value="PROLINE_PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0031">Aminopeptidase</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0464">Manganese</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0482">Metalloprotease</keyword>
    <keyword id="KW-0645">Protease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000411791" description="Probable Xaa-Pro aminopeptidase P">
        <location>
            <begin position="1"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="449"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="460"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="460"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="558"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="572"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="572"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="654" mass="72691" checksum="7AD6FCE3658C5174" modified="2011-07-27" version="2">MLFSRPPARLSWILAFQPSQKLPRYSPRFFSISVSRFAIDMEAVDTTKRLSSLRQLMREHKVDVYIVPSEDSHQSEYIAPCDGRREFISGFSGSAGTAIISLNEAALSTDGRYFNQAAKQLDNNWTLLKRGVEGVPTSQEWITQQAEGGKVVGVDPALITGAAARSLSDALQKSGASLIGVSQNLVDLVWGNDRPAPPREKVRVHPEKYAGKSFQEKVSDLRKELENKKAAGFVISMLDEIAWLLNLRGSDIPYNPVFISYCIVTPTKVELYIDDEKLTPEVKAHLGDDVIIKPYDSIFADAKALFEAKKKDPDAPSSKFLLSNRASWALNLSLGGEDHVEEIRSPIGDAKAVKNEVELAGMRACHIRDGAALIEYFAWLENELVNKKSTLDEVDAADKLEQLRSKQELFAGLSFDTISSTGPNGAVIHYKPEKGSCSVIDPNAIYLCDSGGQYLDGTTDVTRTFHFGQPTELEKKAFTLVLKGCIGLDSAVFPKGTSGFALDVLARQHLWKEGLDFLHGTGHGIGSYLNVHEGPVGIGTRVQYTEVPLAPGNVISDEPGFYEDGKFGIRIENVIMVREVQTTHKFGERPWLGFEHVTMCPIGQNLIEPSLLSDSEIKWLNDYHAEVWEKTHKYFENDEVTRKWLERETRPISK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AVG3</accession>
    <accession>C8VDI0</accession>
    <name>Q5AVG3_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_07717</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF79964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_680986.1">
        <property type="nucleotide sequence ID" value="XM_675894.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AVG3"/>
    <dbReference type="STRING" id="227321.Q5AVG3"/>
    <dbReference type="GeneID" id="2869554"/>
    <dbReference type="KEGG" id="ani:ANIA_07717"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN7717"/>
    <dbReference type="eggNOG" id="ENOG502SWUH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052079_1_0_1"/>
    <dbReference type="InParanoid" id="Q5AVG3"/>
    <dbReference type="OMA" id="ASFECER"/>
    <dbReference type="OrthoDB" id="5427699at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="366"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="130"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="234"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF79964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="411" mass="45025" checksum="3628F01E761D04DB" modified="2005-04-26" version="1">MKSATATKIPNGHGSLYKEVRFSPTSTPIKRSHSVPNDHPTLNLNFGHRRLEMAKETLPTLAIGYLEASRSLLERQRINFDRERTLFAEERQLWEKERELLKTRIRELEALLKSRGVATAPAVGAGIVPSTGVPSTSSPAQVWEGSSPMSRPTRVFPDEEKSESHLHLPSVSEQGAPQPSLDAALSPKSHPTEPLANIPVPIEKLDSSLDGITLKSTALPPDVVARVMTPPSPSSREPSPTSTLQERERPSMDRRSSVKLKLSDLGPPETNLVRDAGHTPMVVIDRDLDTAQGSPGEMGLAEDPLDPPATRLHQPTERADSYFDGVVDLPDDPALQGPLSLVNEKSHDDNFLQEVDMKLLGQAKRILGHREKEDEDEADLDNPSGQGQGEEVPEIKFKNTTNFGTAFGQSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AVI4</accession>
    <accession>C8VC58</accession>
    <name>Q5AVI4_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_07696</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF79925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_680965.1">
        <property type="nucleotide sequence ID" value="XM_675873.1"/>
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    <dbReference type="AlphaFoldDB" id="Q5AVI4"/>
    <dbReference type="STRING" id="227321.Q5AVI4"/>
    <dbReference type="GeneID" id="2869386"/>
    <dbReference type="KEGG" id="ani:ANIA_07696"/>
    <dbReference type="eggNOG" id="ENOG502S0Z0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005620_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AVI4"/>
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    <dbReference type="OrthoDB" id="4489171at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
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        <property type="entry name" value="Ucp6/RUP1"/>
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    <dbReference type="PANTHER" id="PTHR39597">
        <property type="entry name" value="UBA DOMAIN-CONTAINING PROTEIN RUP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39597:SF1">
        <property type="entry name" value="UBA DOMAIN-CONTAINING PROTEIN RUP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="550"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="616"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="682"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="740"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="371"/>
            <end position="409"/>
        </location>
    </feature>
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        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="627"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="740"/>
            <end position="758"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF79925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="878" mass="98129" checksum="8C8166D6D1406EEB" modified="2005-04-26" version="1">MSLNQNLGQQETGVTTTGQHFGRATRDHYEQDDWALTLFNSSAREIVISPDPVDRKRQPAEPAFIRPTQDSLYLSGLFTILHSIPLAREALLLRNKVLSNYGYDAQWWNGQPIYLPKIVSIHDAQDGNTEWDDILYESQRIVAFLDCTTRAFGSTDALAGLKRLETYGSSSAVGTFLEAWQEAAVAADPGNPLATVFSSMAYKRPPKTDDSSATEQEASIDEEPIDKEFFTLEPYVEPIHGQTLYDVLDGTMWSDTPGEELDDVWLEHVADVLTIQLDSVDTTAKAIDVRIPATFYPDRYLASCRDIAREYRLQRLKIREDVVKLRSLMDRLSIGSGLSKGVTSREALEKAADAAASLAPQTESNEDSTSVEKLALQLKAISRKIEDKLKELESRQQQALESLKNYSKYLTEPSTSPGEPPVHKYTLRGVCTEPHVTYVLRRSPPNDTTKPKPDDYEWWRISFSVDDAKSRQAQTGRPAPRDADVIGYTVRKVREVEVLRAAREESKNVLLVYANSNAMNCKEEPAPAPLQRFVSDDNAAFENELQEWEHNADTRQNADTQWERTVGSRPAYPSPSIGQEDVPASKVNVFDYQVASFDDDPAEGQEMQERGVRPLLGQAGSHGHQAPRSSYQNTNPNLPSYLTPLLQRMSSESDTQLETTASSTLYLLESRLNRLTYLLTGDTAWTGTPNPPPKPSSYDETVSRRLQRLESELENLAGKVGVVRDILGLYLFRSTSTLSLPTSTTDQTDTPETTQPSDPETEPSPPLQIMLSIILSYASLISETASRLTSLTDTPIPDASLSASLIALQPRMNQLAAKQDEQSREIAELRVRTAKVLQRYYEVSLLGGGEVWGEWEGRMERVEREVKRVEVARGREGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="111" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AVL4</accession>
    <accession>C8VC23</accession>
    <name>Q5AVL4_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NAD+ kinase Utr1, putative (AFU_orthologue AFUA_2G01350)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ANIA_07666</name>
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    <organism evidence="7 8">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF79861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_680935.1">
        <property type="nucleotide sequence ID" value="XM_675843.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AVL4"/>
    <dbReference type="FunCoup" id="Q5AVL4">
        <property type="interactions" value="550"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5AVL4"/>
    <dbReference type="GeneID" id="2869481"/>
    <dbReference type="KEGG" id="ani:ANIA_07666"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN7666"/>
    <dbReference type="eggNOG" id="KOG2178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008831_7_2_1"/>
    <dbReference type="InParanoid" id="Q5AVL4"/>
    <dbReference type="OMA" id="EHMLKYW"/>
    <dbReference type="OrthoDB" id="24581at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019674">
        <property type="term" value="P:NAD+ metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006741">
        <property type="term" value="P:NADP+ biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.30:FF:000005">
        <property type="entry name" value="NAD+ kinase Utr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10330:FF:000025">
        <property type="entry name" value="NAD+ kinase Utr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.30">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00361">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017437">
        <property type="entry name" value="ATP-NAD_kinase_PpnK-typ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002504">
        <property type="entry name" value="NADK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275">
        <property type="entry name" value="NAD KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275:SF0">
        <property type="entry name" value="NAD KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01513">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20143">
        <property type="entry name" value="NAD_kinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="134"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="584"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="27"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="135"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="594"/>
            <end position="608"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBF79861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="644" mass="70838" checksum="3008DACF05F16D83" modified="2005-04-26" version="1">MASPNFRDDSIKPQNLTDLPCSPSPLTDSAAPPLSDPSPSTSKTVGASLLRDYALHIDPSQTPNEVGRKDSEESFTPAASTASPHRVPAQEDHSPSSNPTAFPFRAAFSVTRHSRKAFSCDLIPRQTIMKALASRPTSNHQNSNMPLAAPFGLQSPTSPSSPPDETERRPHTSSSQKLSAALSNLQLASDADRVPTTRLIMQSPCFFHKRFDDAVNLQKVLEEITDDEWLSHSRLLQTATGVREVSKQLQRRPIKRAVKNVMIVTKARDNSLVHLTRELAEWLLSTPRYGSDLGVNVYVDAKLRHSKRFDAQGLIQKNPAYEHMIRYWTPDLCWTSPEKFDLVLTLGGDGTVLFTSWLFQRIVPPVLCFSLGSLGFLTNFEFENYKSHLNAVMGDVGMRVNLRMRFTCTVFRKDRSKGAEAGAVEEGEQFEVLNELVIDRGPSPYVSNLELYADNDLLTVVQADGCIFSTPTGSTAYSLSAGGSLIHPSIPGILLTPICPHTLSFRPMVLSDSLLLRIAVPSGSRSTAYCSFDGKGRVELRQGDYVTVEASQYPFPTVVANNGEWFQSVQRALRWNTRGAVQKSWHSGDTSVDAADDENEDEEWDIDTDAGYNGTDSGLGPSEDGDAGSNSPMKRQMSLLGMQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="105" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AWA1</accession>
    <accession>C8VBA2</accession>
    <name>Q5AWA1_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">dCMP deaminase</fullName>
            <ecNumber evidence="3">3.5.4.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">dCMP deaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ANIA_07429</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.5.4.12" evidence="3"/>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF79364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_680698.1">
        <property type="nucleotide sequence ID" value="XM_675606.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AWA1"/>
    <dbReference type="FunCoup" id="Q5AWA1">
        <property type="interactions" value="66"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5AWA1"/>
    <dbReference type="GeneID" id="2869397"/>
    <dbReference type="KEGG" id="ani:ANIA_07429"/>
    <dbReference type="eggNOG" id="KOG3127">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047993_0_1_1"/>
    <dbReference type="InParanoid" id="Q5AWA1"/>
    <dbReference type="OMA" id="YFMRLAD"/>
    <dbReference type="OrthoDB" id="6710946at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002333">
        <property type="entry name" value="Deoxycytidylate deaminase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015517">
        <property type="entry name" value="dCMP_deaminase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11086:SF18">
        <property type="entry name" value="DEOXYCYTIDYLATE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11086">
        <property type="entry name" value="DEOXYCYTIDYLATE DEAMINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="5">
        <location>
            <begin position="233"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00041763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBF79364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="314" mass="35632" checksum="93266A428A97E6A6" modified="2005-04-26" version="1">MRERKSLWLVDYSVLNEHIFKSQPLSPLPLFPGFVPYSPAKTKETMLIGLCGGICSGKHAVAEYLIQQQNFRRLEVTTSAPPQFASDPRLHFSDATNNTSGGEPSLVFENFGSLIDFATKRWQERWVTTNIGDASTVDRFLQRPFFLLVSVDAPVSLRWQRFANRCRRRRLDPPSLEEFVLWNDKQLYEKDIGRAFLTDRAQVRLFNSSSSLEKLHAALKALNLADEQRLRPNWDQYFMELASLAAQRSNCMKRRVGCVLVRERRVISTGYNGTPRHLKNCNEGGCMVQGAIAAKAEASACQHASVSTLKKMLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="116" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AWC8</accession>
    <accession>C8VCE1</accession>
    <name>Q5AWC8_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glucoamylase</fullName>
            <ecNumber evidence="9">3.2.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">1,4-alpha-D-glucan glucohydrolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Glucan 1,4-alpha-glucosidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">ANIA_07402</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>Hydrolysis of terminal (1-&gt;4)-linked alpha-D-glucose residues successively from non-reducing ends of the chains with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glycosyl hydrolase 15 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.3" evidence="9"/>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF78451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_680671.1">
        <property type="nucleotide sequence ID" value="XM_675579.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AWC8"/>
    <dbReference type="SMR" id="Q5AWC8"/>
    <dbReference type="FunCoup" id="Q5AWC8">
        <property type="interactions" value="60"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5AWC8"/>
    <dbReference type="CAZy" id="CBM20">
        <property type="family name" value="Carbohydrate-Binding Module Family 20"/>
    </dbReference>
    <dbReference type="CAZy" id="GH15">
        <property type="family name" value="Glycoside Hydrolase Family 15"/>
    </dbReference>
    <dbReference type="GeneID" id="2869878"/>
    <dbReference type="KEGG" id="ani:ANIA_07402"/>
    <dbReference type="eggNOG" id="ENOG502QPM2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012173_1_0_1"/>
    <dbReference type="InParanoid" id="Q5AWC8"/>
    <dbReference type="OMA" id="NRKYTVP"/>
    <dbReference type="OrthoDB" id="6123450at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004339">
        <property type="term" value="F:glucan 1,4-alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001070">
        <property type="term" value="F:starch binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05811">
        <property type="entry name" value="CBM20_glucoamylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000018">
        <property type="entry name" value="Glucoamylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000552">
        <property type="entry name" value="Related to glucoamylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002044">
        <property type="entry name" value="CBM20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034836">
        <property type="entry name" value="CBM20_glucoamylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011613">
        <property type="entry name" value="GH15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000165">
        <property type="entry name" value="Glucoamylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046966">
        <property type="entry name" value="Glucoamylase_active_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008291">
        <property type="entry name" value="Glucoamylase_SBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31616:SF12">
        <property type="entry name" value="GLUCOAMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31616">
        <property type="entry name" value="TREHALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00686">
        <property type="entry name" value="CBM_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00723">
        <property type="entry name" value="Glyco_hydro_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001031">
        <property type="entry name" value="Glu-a-glcsd_SBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00736">
        <property type="entry name" value="GLHYDRLASE15"/>
    </dbReference>
    <dbReference type="SMART" id="SM01065">
        <property type="entry name" value="CBM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="Starch-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51166">
        <property type="entry name" value="CBM20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00820">
        <property type="entry name" value="GLUCOAMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="CBM20" evidence="12">
        <location>
            <begin position="544"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="220"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="223"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR001031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001031-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001031-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CBF78451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="661" mass="70637" checksum="667AE1A51C0955E0" modified="2005-04-26" version="1">MPTTILKITLFPLIDSIFSVQLSPVRIAMLTLSKVLPVLALSHAVAAAPQLSARATASLNTWLSTEASFALDGILTNIGANGAYAKTAKAGADYYTWTRDAALTVKVLVDLFHNGDLSLQTILEEYTNSQAYLQTVSNPSGGLASGGLAEPKFYVDMTAFTGSWGRPQRDGPALRATTLIGFGNWLIDNGYSSYASNNIWPIVRNDLTYVAQYWSKSGYDLWEEVNSMSFFTVAVQHRALVEGSTFAHRVGASCPWCDSQAPQILCYMQNFWTGSYINANTGGGRSGKDANTVLASIHTFDPDAACDDITFQPCSSRALANHKVYTDSFRSVYSLNTGIAQGVAVAAGRYPEDSYYNGNPWFLTTLAAAEQLYDAIYQWQKARSISITSTSLAFFKDIYSSAAVGTYASGSSAFTAIIDAVKTYADGYVSIVKAHAMANGSLSEQFDKTYGTCVSARDLTWSYAALLTASMRRNGVVPPSWDAASANTLPSSCSTGSATGTYSTATVTTWPSTLTSGSASATTTIMATSTATSSSTTTSTTTACTTPSTVAVTFNVIATTTYGENVYIVGSISQLGNWDTGSAVALSASKNTSSNNLWYVDINLPGGTAFEYKYIRKETDGSIVWESDPNRSYTVPSSCGVSTATESDTWRCTLETQSVRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="105" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AWE8</accession>
    <accession>C8VCG3</accession>
    <name>Q5AWE8_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Salicylate hydroxylase, putative (AFU_orthologue AFUA_3G01460)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ANIA_07382</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF78493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_680651.1">
        <property type="nucleotide sequence ID" value="XM_675559.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AWE8"/>
    <dbReference type="STRING" id="227321.Q5AWE8"/>
    <dbReference type="GeneID" id="2869837"/>
    <dbReference type="KEGG" id="ani:ANIA_07382"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN7382"/>
    <dbReference type="eggNOG" id="KOG2614">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009665_6_3_1"/>
    <dbReference type="InParanoid" id="Q5AWE8"/>
    <dbReference type="OMA" id="PSQWAIF"/>
    <dbReference type="OrthoDB" id="417877at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000153">
        <property type="entry name" value="Salicylate hydroxylase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051104">
        <property type="entry name" value="FAD_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720">
        <property type="entry name" value="HYDROXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01460)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720:SF5">
        <property type="entry name" value="HYDROXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01460)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="7">
        <location>
            <begin position="10"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBF78493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="422" mass="46439" checksum="D4E55C8CF8B3D44A" modified="2005-04-26" version="1">MSSPSDKQFTVAIIGGGIGGLSLAAGLLRRSVPVQIYEAAAEFKEVGLGLTIGPAAHRAMPLIDPKIREIYDALITTHADSPGYERFKETWFEVVRASDDDELDGRLVLDLKAKPSGQTTVRRADFLDALVRLVPEGIAHFGKRLAALVETGDGVEMRFEDGTAARASVVIGCDGIHSKVKQFVLGADEYAATQPRYSGMYGYRAVLDMETMVEAVGDHRARVSTMYVGDGAYAVTYPIKRAKKVNVGIYPLHSEWDRESWVRPASKEDMHNDFKHMGRLINSLIEWALYEHPHISTYARARVAILGDAAHASTPHQGAGAGQAIEDAHVLAELLGDARVATADDVAAAFKAYDQVRRPRSQRVVTSSAENAYLLCLRLDGVGSDEEKLKKTLQERLAWLWNEDVHEQAERARRIMLEMIGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AWM2</accession>
    <accession>C8VCP6</accession>
    <name>Q5AWM2_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA polymerase delta subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ANIA_07308</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF78648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_680577.1">
        <property type="nucleotide sequence ID" value="XM_675485.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AWM2"/>
    <dbReference type="STRING" id="227321.Q5AWM2"/>
    <dbReference type="GeneID" id="2869847"/>
    <dbReference type="KEGG" id="ani:ANIA_07308"/>
    <dbReference type="eggNOG" id="ENOG502S6S5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047736_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AWM2"/>
    <dbReference type="OMA" id="QMLYDFH"/>
    <dbReference type="OrthoDB" id="514823at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043625">
        <property type="term" value="C:delta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904161">
        <property type="term" value="P:DNA synthesis involved in UV-damage excision repair"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006297">
        <property type="term" value="P:nucleotide-excision repair, DNA gap filling"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1030.20">
        <property type="entry name" value="DNA polymerase delta, p66 (Cdc27) subunit, wHTH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019038">
        <property type="entry name" value="POLD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041913">
        <property type="entry name" value="POLD3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17598">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17598:SF13">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09507">
        <property type="entry name" value="CDC27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="69"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="170"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="326"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="391"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="93"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="212"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="222"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="253"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="270"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="285"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="347"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBF78648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="438" mass="48272" checksum="E2D9B33CEB095CBD" modified="2005-04-26" version="1">MAIADHKKFLAEAVFHERRTVTYRSLGRALRVHSTLAKQMLYEFHLNENSKKPSSVHATYVLTGVPKPVEPVRNGATANGNGDNEDDIMPSSPYISSSLPNPETESDQVPVSAVLLAREEDLEGNLQPTILQDLNVLTDVSREMLVNHAHEDPLEYGKQWGMVQNTNVMRRTGVRPPPPPSSTVPAKRPAQSEPLQPGKAEIKNEEPPKPLQRQNSASSAKTNEKIPPAKKEKGSLFSSFAKAKPKLKKEDPATSAASAAESTATSGAEDVVDDASEDEQEDLFPESRKEGPSETRESRKERDERLRKMMEDDGGLVSNIVHHRILMSADEDEEMIDATEPPTESETIDKPPPKQEDLKVEATVKGGRRRGRRQVMKKVVKKDSEGYLVTVEEPSWESFSEDEPTPPPPKKKPGVSAPKAKPGTKAGQGNIMSFFGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AWP0</accession>
    <accession>C8VCR6</accession>
    <name>Q5AWP0_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PHF5-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_07290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PHF5 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF78686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_680559.1">
        <property type="nucleotide sequence ID" value="XM_675467.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AWP0"/>
    <dbReference type="FunCoup" id="Q5AWP0">
        <property type="interactions" value="920"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5AWP0"/>
    <dbReference type="GeneID" id="2869765"/>
    <dbReference type="KEGG" id="ani:ANIA_07290"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN7290"/>
    <dbReference type="eggNOG" id="KOG1705">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_110369_1_1_1"/>
    <dbReference type="InParanoid" id="Q5AWP0"/>
    <dbReference type="OMA" id="AYYCWEC"/>
    <dbReference type="OrthoDB" id="10248186at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009410">
        <property type="term" value="P:response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005345">
        <property type="entry name" value="PHF5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13120">
        <property type="entry name" value="PHD FINGER-LIKE DOMAIN-CONTAINING PROTEIN 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03660">
        <property type="entry name" value="PHF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016468">
        <property type="entry name" value="PHF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF78686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="108" mass="12280" checksum="A755E346CDF0847F" modified="2005-04-26" version="1">MSRHHPDLVMCRKQPGISIGRLCDKCDGKCPVCDSYVRPTTLVRICDECSFGNYQNKCIVCGGEGISDAFYCFECTRLEKDRDGCPKIINLGSSRTDLFYQKKSFRNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AXN4</accession>
    <accession>C8V380</accession>
    <name>Q5AXN4_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ANIA_06946</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF71799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_664550.1">
        <property type="nucleotide sequence ID" value="XM_659458.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AXN4"/>
    <dbReference type="GeneID" id="2870410"/>
    <dbReference type="KEGG" id="ani:ANIA_06946"/>
    <dbReference type="eggNOG" id="ENOG502SHVM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028200_3_7_1"/>
    <dbReference type="InParanoid" id="Q5AXN4"/>
    <dbReference type="OMA" id="FHRIWLW"/>
    <dbReference type="OrthoDB" id="5331848at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF155">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="47"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="93"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="129"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="31"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBF71799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="317" mass="35219" checksum="26050A9B813697E7" modified="2005-04-26" version="1">MDLVNLTQTKGPMILGVFWAFFAVSVIMVSARLYIRARWLRNIGLDDYIITVSMIMVTSYTVITTVNVAFGFGKHTPAITAEGGTDLLTRVLLINYIDFAFGILSFTMPKLAISALLNRVMNPGRFHRIWLWVLTALVFVSSSICIVVLFTMCDPPEAMWKPQLVAGGAGTCRPNRILVGYAIFTGDATADLVIWTSIESNIIVIASCIPTLGPLYELILGRRSWSSQERYHYKDKGSNNQRPSFSAERHKRSNLGSYKDADLFITNNISTTPEGSQESILRLDKQAKGGRPAGGIQRTDQVVVEYEMRPLEVGRAV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-11-22" modified="2025-06-18" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AXV1</accession>
    <accession>C8V2Q7</accession>
    <name>MCH1_EMENI</name>
    <protein>
        <recommendedName>
            <fullName>Probable transporter mch1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">mch1</name>
        <name type="ORF">AN6879</name>
    </gene>
    <organism>
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Probable transporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="sequence caution" evidence="4">
        <conflict type="erroneous gene model prediction">
            <sequence resource="EMBL-CDS" id="CBF71650" version="1"/>
        </conflict>
    </comment>
    <comment type="sequence caution" evidence="4">
        <conflict type="erroneous gene model prediction">
            <sequence resource="EMBL-CDS" id="EAA58278" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EMBL" id="AACD01000113">
        <property type="protein sequence ID" value="EAA58278.1"/>
        <property type="status" value="ALT_SEQ"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF71650.1"/>
        <property type="status" value="ALT_SEQ"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_664483.1">
        <property type="nucleotide sequence ID" value="XM_659391.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AXV1"/>
    <dbReference type="FunCoup" id="Q5AXV1">
        <property type="interactions" value="17"/>
    </dbReference>
    <dbReference type="GlyCosmos" id="Q5AXV1">
        <property type="glycosylation" value="2 sites, No reported glycans"/>
    </dbReference>
    <dbReference type="KEGG" id="ani:ANIA_06879"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN6879"/>
    <dbReference type="eggNOG" id="ENOG502QTNE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_709742_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AXV1"/>
    <dbReference type="OrthoDB" id="199930at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17354">
        <property type="entry name" value="MFS_Mch1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21576:SF45">
        <property type="entry name" value="TRANSPORTER MCH1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21576">
        <property type="entry name" value="UNCHARACTERIZED NODULIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <keyword id="KW-0926">Vacuole</keyword>
    <feature type="chain" id="PRO_0000084871" description="Probable transporter mch1">
        <location>
            <begin position="1"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="371"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="428"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="477"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="512"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="538"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="583"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="112"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="615" mass="67542" checksum="636B759C77BF8BC6" modified="2005-11-22" version="2">MTGSIGQAPAIDKRDFDINRRSSTPHETAAQEDEALLHSRPRSRLSVGNRFSDNDDGLLSDVVEEIVERDRQRMRREVVRVGSFVWGVITCLGAGSITAFSLYGPLLLTRLNYTQLRVNEVSIAAGISMYLPVSLAGYLCDRYSPSPLTLFAGIAFGLGYSLAAFVYKSGPPPDAGGNGWPFWVMVVAFIAIGVATCSMYLAAVTTCAKNFGRGKHKGIILAVPIAAFGLSGMWQSQVGTYFLCERLKDSNCGDVDVYKYFLFLAILLLTIGVIGTFALRIVDDEEEKYIDEAVEELERSGLLAESEFFRPRSEVQAAYGTFSDDHEDNGSVDDQSVTISEELREAARREKEREEEERRKKNWLLNYETRIFLADHTMWWLALGFFLVTGPGEAYLNNLGTIVQTLNLDTTAIVDSHPAGLPSTHVTIIALTSTIARLLTGSLSDLFAPTARRHFTVDQETAGPDPFTKQRPALSRLAFLIPSALLLSLGFLLLASPLPTHHPELSHLTTALVGLGYGSIFSLVPIIISVVWGVENFGTNWGIVAMFPAAGAAMWGVIYSRAYQSAADGSPTDDGQCHGWKCFGFWSIGCTFSVWVAIVAWLVAWTSWRRRGVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AXX4</accession>
    <accession>C8V2N3</accession>
    <name>Q5AXX4_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_06856</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF71603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_664460.1">
        <property type="nucleotide sequence ID" value="XM_659368.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AXX4"/>
    <dbReference type="STRING" id="227321.Q5AXX4"/>
    <dbReference type="GeneID" id="2870558"/>
    <dbReference type="KEGG" id="ani:ANIA_06856"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN6856"/>
    <dbReference type="eggNOG" id="ENOG502SC0A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_135765_1_0_1"/>
    <dbReference type="InParanoid" id="Q5AXX4"/>
    <dbReference type="OMA" id="NPPDSNR"/>
    <dbReference type="OrthoDB" id="3358750at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39475">
        <property type="entry name" value="CONIDIATION-SPECIFIC PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39475:SF1">
        <property type="entry name" value="CONIDIATION-SPECIFIC PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF71603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="120" mass="13446" checksum="AFC28DFE3E65AD41" modified="2005-04-26" version="1">MSSSSQSNVGRGAFYEAGDQRTAPQSEINQHERYEAGEKASHKNIDSKDQRTIANRLAAQSKEDDPSSHHNRDIQPEAELSKKDPLKPAKLHGNEPSKGAKIDKQLQEDDEQRLREKGIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="121" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AY19</accession>
    <accession>C8V2F1</accession>
    <name>Q5AY19_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ANIA_06811</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF71509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_664415.1">
        <property type="nucleotide sequence ID" value="XM_659323.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AY19"/>
    <dbReference type="STRING" id="227321.Q5AY19"/>
    <dbReference type="GeneID" id="2870492"/>
    <dbReference type="KEGG" id="ani:ANIA_06811"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_11_2_1"/>
    <dbReference type="InParanoid" id="Q5AY19"/>
    <dbReference type="OMA" id="TIMISYI"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF56">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="116"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="208"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="39"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBF71509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="279" mass="31578" checksum="2BDC88E4387AF7BB" modified="2005-04-26" version="1">MASSPPKEPHLEQLEVGRRAETEPSLRDTLRYYQPAVIWSVLISLTTVMESYDMQIVHSFYAFPHFQREYGVQLKNGEYSIPAKWQLALNCASLLGLMSGTFLNGWASERFGARKVIMISLIALTAFVAITFVSPSVEVLFVGELLYSIPWGFSPLPPRRMRQICPLVRRGYVTAFVNPCWVMGRLISTGVLTGTLNIPSQGPYRLPFALQWIFPLPLFIVAWFCPESPWTNLRRSEISIISWGCQLLPCWAIQNYITYFFSLAGLSPGNLFKITLGIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AY77</accession>
    <accession>C8V1Z4</accession>
    <name>Q5AY77_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NADH-dependent flavin oxidoreductase, putative (AFU_orthologue AFUA_7G06420)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_06753</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF71392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_664357.1">
        <property type="nucleotide sequence ID" value="XM_659265.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AY77"/>
    <dbReference type="SMR" id="Q5AY77"/>
    <dbReference type="STRING" id="227321.Q5AY77"/>
    <dbReference type="GeneID" id="2870248"/>
    <dbReference type="KEGG" id="ani:ANIA_06753"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN6753"/>
    <dbReference type="eggNOG" id="KOG0134">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012153_2_1_1"/>
    <dbReference type="InParanoid" id="Q5AY77"/>
    <dbReference type="OMA" id="ANIPWGP"/>
    <dbReference type="OrthoDB" id="72788at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003959">
        <property type="term" value="F:NADPH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02932">
        <property type="entry name" value="OYE_YqiM_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044152">
        <property type="entry name" value="YqjM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43303:SF7">
        <property type="entry name" value="FLAVIN OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G06420)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43303">
        <property type="entry name" value="NADPH DEHYDROGENASE C23G7.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="2">
        <location>
            <begin position="40"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF71392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="422" mass="45620" checksum="816A740B5A987C62" modified="2005-04-26" version="1">MALPDVENTPAAGIPYFTPAQNPPAGTAANPQTSGNAVPKLYTPLTVRGVTFHNRLGLAPLCQYSAEDGHMTDYHIAHLGGIAQRGPGLMMIEATSVSPEGRITPQDVGLWKDSQIAPMKRVIDFVHSQSQKIGVQIAHAGRKASNIAPWLMNKGIVATEKVGGWPDRVIGPSTVPFHETFPTPKAMTKDDIEQFKRDWFDACKRAIAAGADFIEIHNAHGYLLSSFLSPSSNTRTDEYGGSFENRIRLSLEIAQVTRDAVGPNVPVFLRVSATDWIEETLPEESWKLSDSVRFAEALAAQGAIDLIDVSSGGVHAAQKIKSGPAFQAPFAVAIKKAVGDKLLVATVGTITNGKQANKLLEEEGLDVALVGRGFQKDPGLAWTFAQHLDVEIAMASQIRWGFTRRGGTPYIDPKAYKESIFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="151" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AYI8</accession>
    <accession>C8V1C8</accession>
    <name>Q5AYI8_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">P-type Na(+) transporter</fullName>
            <ecNumber evidence="19">7.2.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">ANIA_06642</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="25" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="25">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>K(+)(in) + ATP + H2O = K(+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:75815"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>Na(+)(in) + ATP + H2O = Na(+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:14634"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IID subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.3" evidence="19"/>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF71157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_664246.1">
        <property type="nucleotide sequence ID" value="XM_659154.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AYI8"/>
    <dbReference type="FunCoup" id="Q5AYI8">
        <property type="interactions" value="47"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5AYI8"/>
    <dbReference type="GeneID" id="2870393"/>
    <dbReference type="KEGG" id="ani:ANIA_06642"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN6642"/>
    <dbReference type="eggNOG" id="KOG0202">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002360_3_3_1"/>
    <dbReference type="InParanoid" id="Q5AYI8"/>
    <dbReference type="OMA" id="ASRFNWG"/>
    <dbReference type="OrthoDB" id="3352408at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008556">
        <property type="term" value="F:P-type potassium transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008554">
        <property type="term" value="F:P-type sodium transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034220">
        <property type="term" value="P:monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd02086">
        <property type="entry name" value="P-type_ATPase_Na_ENA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000016">
        <property type="entry name" value="Calcium-transporting P-type ATPase putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000001">
        <property type="entry name" value="Phospholipid-transporting ATPase IC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000015">
        <property type="entry name" value="Sodium ion P-type ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000020">
        <property type="entry name" value="Sodium ion P-type ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000039">
        <property type="entry name" value="Sodium P-type ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000047">
        <property type="entry name" value="Sodium P-type ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
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    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
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    <dbReference type="InterPro" id="IPR006414">
        <property type="entry name" value="P-type_ATPase_IID"/>
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    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
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    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01523">
        <property type="entry name" value="ATPase-IID_K-Na"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
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    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="16 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0915">Sodium</keyword>
    <keyword evidence="17" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="12" id="KW-1278">Translocase</keyword>
    <keyword evidence="6 22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 22" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="293"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="320"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="787"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="824"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="864"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="911"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="962"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="995"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="23">
        <location>
            <begin position="17"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
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            <dbReference type="ARBA" id="ARBA00022958"/>
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            <dbReference type="ARBA" id="ARBA00022967"/>
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            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00831"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="CBF71157.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="1066" mass="117320" checksum="9862830CB52C2329" modified="2005-04-26" version="1">MGEETEQKGHVQPLSRPAHTLSPDEILRELKVNSEEGLTAAEAKKRLELFGPNELEGGEGVSLAKIIIRQIANAMMLVLIIAMAVSFGIESWIEGGVIGAVIGLNIVVGVYQDYAAEKTMDSLRNLSSPTGVATRDGKTNTIPATEIVPGDMIELKVGDTVPADVRLVDAMNFETDEALLTGESLPVQKEVDVTFAEDTGPGDRLNIAYSSSTVTRGRARGVVIGTGMKTEIGAIAAALHANDSKRRPVKRGPGGETKKRWYVQAWTLTATDAVGRFLGINVGTPLQRKLSKLALLLFGIAVVFAIVVMGANEMRNDKEVIIYAVATGLAMIPACLVVVLTITMAVGTKQMVERHVIVRRLDSLEALGAVTNICSDKTGTLTQGKMVAKRAWIPSLGTYSVGSSNNPLDPTEGELSLLPDPPVKLERDARGDPADPAELIKDNKILEDYLNVASMANLAVVHRSEGNEWQARGEPTDIAIQVFAHRFNWGRERWTKGEKPIWRQKAEYPFDSTVKKMSVIFAREDDSEKGRQMVFTKGAVERVIDSCTTILWTRNEDPIPMSEDIKSQILQNMEALAKEGLRVLCLASREFDTPIANSEEVPPREEVEKDLVFCGLVGLYDPPRPETAGAIEECYRAGISVHMVTGDHPGTARAIAAQVGIIPANMDGIAKDVADAMVMTASQFDKLTDEEIDDLPTLPLVIARCAPTTKVRMIDALHRRGRYAAMTGDGVNDSPSLKRADVGIAMGEAGSDVAKDASELVLTDDNFASIINGIEEGRRIFDNIQKFVLHLLAENVGLALTLLIGLVFKDEAGQSVFPIAPVEILWIIMITSGAPDMGLGMEVAAPDVMDRPPQSKQGIFTWEIIVDMLVYGVWMAALCLTAFSLVLYVWGDGNLARGCNANYSQECDTVFRARATTFVCMTWFALFLAWEMINMRRSFFRMQPGSKKYFTQWMHDVWRNKFLFCGVMLGFVTTFPVLYIPVINDVVFMHTGISWEWGVVVVEAILFFAGVELWKWCKRIYFRRESVQNRNKVDVYRGPQDFSRYTTMSRSETQATGDFKAEQNIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="113" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AYR2</accession>
    <accession>C8V0V1</accession>
    <name>Q5AYR2_EMENI</name>
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        <submittedName>
            <fullName evidence="6">SET domain protein (AFU_orthologue AFUA_6G04520)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ANIA_06568</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
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        <property type="protein sequence ID" value="CBF71002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_659080.1"/>
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        <property type="component" value="Chromosome I"/>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="Ribosomal lysine N-methyltransferase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal lysine N-methyltransferase 4"/>
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        <property type="entry name" value="Rubisco LSMT, substrate-binding domain"/>
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        <property type="entry name" value="Rubisco_LSMT_subst-bd"/>
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        <property type="entry name" value="SET_dom_sf"/>
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        <property type="entry name" value="SETD3_SETD6_MTase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271:SF34">
        <property type="entry name" value="N-LYSINE METHYLTRANSFERASE SETD6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271">
        <property type="entry name" value="UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09273">
        <property type="entry name" value="Rubis-subs-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81822">
        <property type="entry name" value="RuBisCo LSMT C-terminal, substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SET"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SET" evidence="5">
        <location>
            <begin position="34"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="460"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBF71002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="484" mass="54272" checksum="F8B44DF96E8BF2FD" modified="2005-04-26" version="1">MSSSAHFPDRDNFQCRSDEFTTWLSSRPGVKVNSKIRIADLRANAAGRGVVAQADIDEDEELFAIPRDLVLSTHNSKLKDLLSQDLDQLGPWLSLMLVMIFEYLQGGKSTWAPYFKVLPQNFDTLMFWSPEELEELQGSAVVEKIGKQGAEESILKLIIPVVRANPALFPPINGLASYDGDVGAQALLGLAHTMGSLIMAYAFDIETPENEDEREGEDGYLTDEEEEQSSKGMVPLADMLNADAYRNNARLFQEEESLVMKAIKPIRAGEEIFNDYGEIPRSDLLRRYGYVTDNYASYDVIELSLDTLCSSAGLSDSSIENQPRLEFLESLELLDDGYAISRPSPNDTLTDIIPEELVVLLKTLTLSPEQFTHQQQKQKPPKAAFGQEEAKILFDSILMSEKRYSTTIEQDQELLAQINQVEAVSPLEGSDRRRKMAIQVRLGEKEIFEAVKAKINDHFTNSSTSKRIADSNGDDLRRTKVQRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AZC3</accession>
    <accession>C8V0Y2</accession>
    <name>Q5AZC3_EMENI</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ANIA_06357</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF69633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_663961.1">
        <property type="nucleotide sequence ID" value="XM_658869.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AZC3"/>
    <dbReference type="GeneID" id="2871255"/>
    <dbReference type="KEGG" id="ani:ANIA_06357"/>
    <dbReference type="HOGENOM" id="CLU_2210004_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AZC3"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF69633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="107" mass="11809" checksum="681E9BE092742EB4" modified="2005-04-26" version="1">MIFTANRITTLTIPVAWVSERDILPVESVYRKVCLYHGRNPPMKSAGRIVTIKNKGSSGKKPEGMASSIEKKIYIPPGLNRSTSMGCFGIAYQDQSQYLSTVALSQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AZL1</accession>
    <accession>C8V1H3</accession>
    <name>Q5AZL1_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Translocation protein SEC62</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">ANIA_06269</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SEC62 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF69815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_663873.1">
        <property type="nucleotide sequence ID" value="XM_658781.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AZL1"/>
    <dbReference type="FunCoup" id="Q5AZL1">
        <property type="interactions" value="121"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5AZL1"/>
    <dbReference type="GeneID" id="2870999"/>
    <dbReference type="KEGG" id="ani:ANIA_06269"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN6269"/>
    <dbReference type="eggNOG" id="KOG2927">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040936_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AZL1"/>
    <dbReference type="OMA" id="WGWQETK"/>
    <dbReference type="OrthoDB" id="200187at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031204">
        <property type="term" value="P:post-translational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004728">
        <property type="entry name" value="Sec62"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011553">
        <property type="entry name" value="Sec62_asco"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00869">
        <property type="entry name" value="sec62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12443">
        <property type="entry name" value="TRANSLOCATION PROTEIN SEC62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12443:SF9">
        <property type="entry name" value="TRANSLOCATION PROTEIN SEC62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03839">
        <property type="entry name" value="Sec62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="243"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="270"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="62"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="334"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="23"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="62"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="94"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="352"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="381"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CBF69815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="394" mass="43373" checksum="1F0784299FA583C8" modified="2005-04-26" version="1">MATPGQPTPQQLAAMQQQFAAEAAKRGLTPEEFAKQQREQLNAEAAKHGMTTEQYVTQLRMRAMAAQQKAAEVQRQLQANGQSQGPPRPGQPGQPGQPQTHTQQVPVNPNSPKDPKAIAVAQFLRSQNLKPRTCIMDGQRKDMFKVKRAIRALESPAYEKARKKNPLLPPVTDRASAENVFKLLPLSVLALRVSKVDPHAGHGHGKTKRVKGLWTVKIEQHQEADPMMHYVWLYEGPQWKQKAMAAAVVAGIFAVVLFPLWPIMLRQAVWYLSVGMMGLLGLFFAMAIFRLILFCITVFAVPPGLWLFPNLFEDVGFFDSFKPLWGWQETGKKKKKSKKAASSAAQTSNPQATESAPAATAETAPAATTTATESADAAGPVKRDLAPRVEEVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="102" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B0N5</accession>
    <accession>C8UZV6</accession>
    <name>Q5B0N5_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rab GDP dissociation inhibitor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_05895</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the Rab GDI family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF70616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_663499.1">
        <property type="nucleotide sequence ID" value="XM_658407.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B0N5"/>
    <dbReference type="FunCoup" id="Q5B0N5">
        <property type="interactions" value="823"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5B0N5"/>
    <dbReference type="GeneID" id="2870706"/>
    <dbReference type="KEGG" id="ani:ANIA_05895"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN5895"/>
    <dbReference type="eggNOG" id="KOG1439">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021695_0_1_1"/>
    <dbReference type="InParanoid" id="Q5B0N5"/>
    <dbReference type="OMA" id="FETKAKM"/>
    <dbReference type="OrthoDB" id="9446342at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005093">
        <property type="term" value="F:Rab GDP-dissociation inhibitor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.405.10:FF:000001">
        <property type="entry name" value="Rab GDP dissociation inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.405.10">
        <property type="entry name" value="Guanine Nucleotide Dissociation Inhibitor, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.519.10">
        <property type="entry name" value="Guanine Nucleotide Dissociation Inhibitor, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018203">
        <property type="entry name" value="GDP_dissociation_inhibitor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000806">
        <property type="entry name" value="RabGDI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11787:SF8">
        <property type="entry name" value="RAB GDP DISSOCIATION INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11787">
        <property type="entry name" value="RAB GDP-DISSOCIATION INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00996">
        <property type="entry name" value="GDI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00892">
        <property type="entry name" value="RABGDI"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00891">
        <property type="entry name" value="RABGDIREP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF70616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="468" mass="52304" checksum="9CD9E701F9F91767" modified="2005-04-26" version="1">MDEIAPEYDVIVLGTGLTECVLSGVLSVKGNKVLHIDRNDHYGGEAASVNIETLFKKYGNVRPGEEPWKKYGRVNDWNVDLVPKLLMANGELTNILVSTDVTRYLEFKQIAGSYVQQGKGPKATVAKVPSDAGEALRSSLMGMFEKRRAKKFLEWVGEFKEDDPSTHQGLNIATCTMKDVYDKFSLEDNTRDFVGHSMALYQDDDYINRPGTASDAINRIRLYVNSMARYGKSPYIYPLYGLGELPQGFARLSAIYGGTYMLNTDIDEVLYDENGKVSGIKATMKDREDGGETMKFETKTKKIIADPSYFPGKVSVSGYLLKAICILKHPIDKTDGSDSLQLIIPQSQVGRKRDIYVAMVSSAHNVCPKGYYIAIVSTIAETDSNHHLELEPGFERLGDIEEKFFPPPIPLYQPLEDGKKDNIFISKSYDATSHFETTTDDVRDIYRRATGEELVVEGLREGQTLAQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B185</accession>
    <accession>C8VFP8</accession>
    <name>Q5B185_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DUF636 domain protein (AFU_orthologue AFUA_7G04120)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ANIA_05695</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF81389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_663299.1">
        <property type="nucleotide sequence ID" value="XM_658207.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B185"/>
    <dbReference type="GeneID" id="2871988"/>
    <dbReference type="KEGG" id="ani:ANIA_05695"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN5695"/>
    <dbReference type="eggNOG" id="ENOG502S13F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038839_0_0_1"/>
    <dbReference type="InParanoid" id="Q5B185"/>
    <dbReference type="OMA" id="YREFCNR"/>
    <dbReference type="OrthoDB" id="5422068at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1590.10">
        <property type="entry name" value="glutathione-dependent formaldehyde- activating enzyme (gfa)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337:SF32">
        <property type="entry name" value="DUF636 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_7G04120)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337">
        <property type="entry name" value="GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="5">
        <location>
            <begin position="3"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBF81389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="336" mass="37275" checksum="D6CE31471CD5266E" modified="2005-04-26" version="1">MEHRISCLCAQVTQQVLLEPTNNALNLCHCTACRTVSGQIYASYYLLQMEPRLENLEIYRQSDLLCRYFCGTCGSHVFAHAIHTGRFLVASGLVDSPPQTESIQHWVVGDTQDGGLSYYLPGDVGKADVSCWVSQSNRQTAAAKTETDNARLLAGCHCGGIEFYITRPDSASEEPWSDWSDILVPYHSEASAENEEDVKWWLCAGKTKYLAGTCACRTCRLASGFPIQTWAFVPKSNILTAQNSELAFGAGTMKRYESSPQIYREFCSRCGASVFWHCEKRPLLIDVSVGLLRAESGSRAEEWLEWATGRTSFAEMAVDKSLIQRLEAGLAESCSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="110" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B1P9</accession>
    <accession>C8VG81</accession>
    <name>Q5B1P9_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tubulin-specific chaperone E</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Tubulin-folding cofactor E</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ANIA_05531</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TBCE family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF81726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_663135.1">
        <property type="nucleotide sequence ID" value="XM_658043.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B1P9"/>
    <dbReference type="FunCoup" id="Q5B1P9">
        <property type="interactions" value="621"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5B1P9"/>
    <dbReference type="GeneID" id="2871821"/>
    <dbReference type="KEGG" id="ani:ANIA_05531"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN5531"/>
    <dbReference type="eggNOG" id="KOG3207">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017716_3_1_1"/>
    <dbReference type="InParanoid" id="Q5B1P9"/>
    <dbReference type="OMA" id="SEESHMF"/>
    <dbReference type="OrthoDB" id="5273213at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043014">
        <property type="term" value="F:alpha-tubulin binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007023">
        <property type="term" value="P:post-chaperonin tubulin folding pathway"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.190:FF:000008">
        <property type="entry name" value="Tubulin-specific chaperone E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001277">
        <property type="entry name" value="Tubulin-specific chaperone, putative (AFU_orthologue AFUA_4G11870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001878">
        <property type="entry name" value="Tubulin-specific chaperone, putative (AFU_orthologue AFUA_4G11870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050333">
        <property type="entry name" value="SLRP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45712">
        <property type="entry name" value="AGAP008170-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45712:SF22">
        <property type="entry name" value="INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN COMPLEX ACID LABILE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="CAP-Gly" evidence="9">
        <location>
            <begin position="31"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBF81726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="606" mass="69084" checksum="8C603EA359CFFDE2" modified="2005-04-26" version="1">MNTSPVAVYPHPWVNQRRSYDGHLCTIRYVGKVDGTSGEWLGVEWDDPTRGKHSGQHNGVRYFRCLRNHPTAGSFVRPSRPADSPRSFLEAVREKYASDFEQSRERQARPDAEFEEPIRFKSKIAEEVGFDKIRKQLAELEELKIVLLDGLRVAGLLAQEASREQVEEARGQIERTCPKIVELDLSWNMLTKWRDVSDICRPLRRLSLLKLNGNRFEPVEEGLRFDGIKELHLDDTLLPWEQISRVAAQFPSLTWLSASANQISMVRTPISNTIITLILDNNEIGSLSSIRALTSLQNLEHLSLRGNCIDAVAAAETEGHSFQFSRSLRSVDLSRNKINSWLFINQLPEIFPGLRSLRVSGNPLYNQAVAPSSITGLPERPMTVDEAYMLTLSRLSALEVLNYSTISEKDRNNGELYYLSLIGKELSALPETAEPDIHKAHPRYRELCRIYGEPLIQRASKATGSGAALNPRSVAARLVRMVFHLTQAEWASNHHETVKVKEIPRSYDTYQVKAIVSRLFGITPFEFRLIWETDEMDPVSKKNMDIEDEWDSEDEDVYGEGTLKPRDDPKFVKREVELVDTTKDIGFWFQPDLLEAKIRVEVTPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="123" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B1Z7</accession>
    <accession>C8VGI8</accession>
    <name>Q5B1Z7_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytochrome P450, putative (Eurofung)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ANIA_05433</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF81918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_663037.1">
        <property type="nucleotide sequence ID" value="XM_657945.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B1Z7"/>
    <dbReference type="STRING" id="227321.Q5B1Z7"/>
    <dbReference type="GeneID" id="2871723"/>
    <dbReference type="KEGG" id="ani:ANIA_05433"/>
    <dbReference type="eggNOG" id="KOG0158">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_14_0_1"/>
    <dbReference type="InParanoid" id="Q5B1Z7"/>
    <dbReference type="OMA" id="FTMPLWR"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF103">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="441"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBF81918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="507" mass="57406" checksum="D858C74FB4CCD630" modified="2005-04-26" version="1">MALLESAVVLQVFRDVTPMAILATLLLTTFLTYVVYMRHFHPLSQCPGPFFASLSNTYKAYYVYKLTIHEKLLELHNTYGPIVRVGPNHLHTWKGDAIALIYKGGRSMGKSEFYDAFTAFRPNLFGGRDEDIHALRRRQLSHGFAQVSVAKLEPLIDGQMAILISKLRHYARTGQAFDLKHALNLYVLDILGEVAFAKAFDVQNTEDNEKLHAINDHLLLAGVIGELPCQNFTKFLSRLSPVPWMRRLMKSRNKLKEICAGCVRFKIENLEATKSRPDLLRSLVEATDPESGKSVAGSHSTAGTLTLLFWHLIQNPSIMRKVQAEIENTLGPLKDRTSYPIAGIESTLKYTMACVRENFRINPVFTMPLWRRVGKSHVLEIDGHHIPEGTNICISNYVLHHNPSVFGPDHNTFVPEKWLDESYNREKGRYLIPFSVGHRMCIGRNLAMTNILKSVCTLATLFEFEPVEKKKDVRVISPGIGEMKGGFEVRVRVREVKRGSYKNALST</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="106" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B2Q5</accession>
    <accession>C8VF48</accession>
    <name>Q5B2Q5_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta hydrolase family protein, putative (AFU_orthologue AFUA_6G07060)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_05175</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF81019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_662779.1">
        <property type="nucleotide sequence ID" value="XM_657687.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B2Q5"/>
    <dbReference type="ESTHER" id="emeni-q5b2q5">
        <property type="family name" value="6_AlphaBeta_hydrolase"/>
    </dbReference>
    <dbReference type="GeneID" id="2871465"/>
    <dbReference type="KEGG" id="ani:ANIA_05175"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN5175"/>
    <dbReference type="eggNOG" id="ENOG502S1BG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_11_1_1"/>
    <dbReference type="InParanoid" id="Q5B2Q5"/>
    <dbReference type="OMA" id="DVASPYG"/>
    <dbReference type="OrthoDB" id="408373at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050266">
        <property type="entry name" value="AB_hydrolase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798:SF33">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G14860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="101"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF81019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="405" mass="44170" checksum="47296774ED23EFB4" modified="2005-04-26" version="1">MASWCSVERLPVSLADNRFQYTLLAAAGISLSLGLFLRALYPCHPMESKTYYSPLAATQAAGTNNKDHPLPIDVLPGGRDVQTPYGSIRVYEWGPEHGPKVLLVHGITTPCISLGGLAHGLVDRGCRVMLFDLFGRGYSDCPADLPQDERLFASQIFLALSSSPISWTGAGSGKFCLVGYSLGGGIATSFASFFPQLLSALVLLAPAGLIRDKHISFRTRFLYSGGLPDRLLKYLSGIRLRAGPISTPKPQHKKLNTGDAFTEELPSKKEEETQLLSRSYPHVTVPAAVSWQVNNHTGFVHAFVSSMRYGPILSQRQRETWERLGSHLSKQKVLSAAVQKSNGLPSDKVVIMYGSNDSIIIQDELIEDANATLGNSVVFKNFAAGHEFPSTKYDEVAQIIFDTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="100" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B2V3</accession>
    <accession>C8VEY9</accession>
    <name>Q5B2V3_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ER-golgi SNARE complex subunit Bet1 (Eurofung)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ANIA_05127</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endomembrane system</location>
            <topology evidence="8">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF80910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_662731.1">
        <property type="nucleotide sequence ID" value="XM_657639.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B2V3"/>
    <dbReference type="FunCoup" id="Q5B2V3">
        <property type="interactions" value="240"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5B2V3"/>
    <dbReference type="GeneID" id="2871418"/>
    <dbReference type="KEGG" id="ani:ANIA_05127"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN5127"/>
    <dbReference type="eggNOG" id="KOG3385">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086133_1_0_1"/>
    <dbReference type="InParanoid" id="Q5B2V3"/>
    <dbReference type="OMA" id="MNRMLIM"/>
    <dbReference type="OrthoDB" id="261831at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048280">
        <property type="term" value="P:vesicle fusion with Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd15853">
        <property type="entry name" value="SNARE_Bet1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000057">
        <property type="entry name" value="SNARE complex subunit (Bet1), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039899">
        <property type="entry name" value="BET1_SNARE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12791">
        <property type="entry name" value="GOLGI SNARE BET1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CBF80910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="168" mass="18889" checksum="E59EDB88C0B0D49C" modified="2005-04-26" version="1">MASRFSRSDLHRRDPRASSSLFDSYDGISRPASKSPGNVGGYGYGSYPGADRSMNGNGYTGYKSAMPNSKGHYSDAVLSHLESQNEEEVEGITAKVRMLKDLTLAIGDEIRDTTHISDLNDSFENTRTRIRGNMNRMMRMAERTGVGWKVWAGFFALVFFLFFYVWIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="117" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B371</accession>
    <accession>C8V8L5</accession>
    <name>Q5B371_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA-binding protein (Nab3), putative (AFU_orthologue AFUA_3G09770)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ANIA_05009</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF76287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_662613.1">
        <property type="nucleotide sequence ID" value="XM_657521.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B371"/>
    <dbReference type="SMR" id="Q5B371"/>
    <dbReference type="STRING" id="227321.Q5B371"/>
    <dbReference type="GeneID" id="2872802"/>
    <dbReference type="KEGG" id="ani:ANIA_05009"/>
    <dbReference type="eggNOG" id="KOG0118">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013226_1_0_1"/>
    <dbReference type="InParanoid" id="Q5B371"/>
    <dbReference type="OMA" id="LENQMDP"/>
    <dbReference type="OrthoDB" id="10044938at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12342">
        <property type="entry name" value="RRM_Nab3p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034167">
        <property type="entry name" value="Nab3_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052600">
        <property type="entry name" value="Nuc_rcpt_coact/corep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23295:SF6">
        <property type="entry name" value="NEOSIN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23295">
        <property type="entry name" value="NUCLEAR RECEPTOR COACTIVATOR 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="413"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="245"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="319"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="476"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="778"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="831"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="34"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="60"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="93"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="193"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
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            <begin position="245"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
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            <begin position="321"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
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            <begin position="344"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
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            <begin position="367"/>
            <end position="378"/>
        </location>
    </feature>
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            <begin position="525"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
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            <begin position="566"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="784"/>
            <end position="794"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBF76287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="888" mass="96303" checksum="C90572738F845A8F" modified="2005-04-26" version="1">MTPDSPDEALHFRGKTLTPESPRPLHVPEPTSIPVLQNQMDPVFNDTSTYGQAEDLPGNSYRTQSSEQYMRSSEAGWHTDSARRGQEHPPPQQQSHIQGSLQSGPPLMNDGLADSDTTSPSTLATSAALPTSPNPVPSSEPSSVGKAMDSSLTAHAPSDPSSLEAYPVPDAHPYPSHAARNNSFANEVDHSIGTLQAQTASQGRLDAEGKLEGNSAGNGVDFQNLLDNLPSSSTSAPALTVSTTAMAADHASSQAAADEAHQSSLGLPPRPPPQEKPSIHPNYNPTVDIRSYHQLPAHNASTSSNPYAAQPSNYQSNVGVPSLAAGAPGTSSTAGTLPPPPVASFQQPSTSPAENQEPPAPATQKNGRVDRQPLRSDDDAPWGPEVQKKYDAFLHDERVYVTEGLWDRFPYGSRLFVGNLPTERVTKRDLFHIFHSYGKLAQISIKQAYGFIQFLEASSCKRALEGEQGAIVRGRKVHLEISKPQRNTRPAPAPSEPSRVTSARRSRSPDYGRGGPSSNRSSRVPGDRYDRPHEPARLPFSDFRDEPSHRRREDYRPPRSPSPRGYRREGYRSRDRTPERFDRRDRRRSRSPYGRDRRYRSPSPRGRATYDSDVDIPVPRRAPRDVPDVQILVLEELDRNFIYHVESSFRNRGLRVDVLALGARIPLDAAVKRQASEGVLAVIFDRSAGVDNVRSIEYPDLEPHMAAEIVVQAQTLQRTAPNVPLPSPAYGVPQLPSAPLHPAGPALPTQPNLANAISHLDGAGLQSLLAALQQRPAVPATQQPIPPVPNPVPTPDLASLLNAATRQPAPLSAPQPSVPQQSLTQTLPQQPLASQPFPLHGHGASPISDPNLLSLLAKGLGGHHPQGQPPMAPHQVQNLMSQLGKWKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B3H3</accession>
    <accession>C8V9G1</accession>
    <name>Q5B3H3_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_04907</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF76504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_662511.1">
        <property type="nucleotide sequence ID" value="XM_657419.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B3H3"/>
    <dbReference type="STRING" id="227321.Q5B3H3"/>
    <dbReference type="GeneID" id="2872708"/>
    <dbReference type="KEGG" id="ani:ANIA_04907"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN4907"/>
    <dbReference type="eggNOG" id="ENOG502S27H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011198_0_0_1"/>
    <dbReference type="InParanoid" id="Q5B3H3"/>
    <dbReference type="OMA" id="CGMHISR"/>
    <dbReference type="OrthoDB" id="4159838at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="446"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="727"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="761"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="967"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="794"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="813"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="857"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="899"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1020"/>
            <end position="1031"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF76504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="1031" mass="113627" checksum="6616443769CFF2EF" modified="2005-04-26" version="1">MEDVRPTAKWANRMLRPLASIYHRLEKHHEIVTSVLTSKTREKIGAAPAPDTEQRTRPPRRTKSTERGLNHSDDDDELNDPAWIPGKSMDKRRIRHNYSSRGRGAGLGPRRRSRLLIRSPEAPKTLPGAIEIATPLITGKLRGSPLTETSPSLKMQLFQNRLSESSGGGSTEHRRSGRTHKAVFRPYQGSWKEILDQSGDPRLVDIAHLLDRIFLKFLGNTRVAFDRGGARSLLSTAVRRLPDFIAEEQRIQDELEEGCDIDMCDAYFTELEAVYAPGGDGWQPLREAVRAQGIYLVSCMIQNKWITSLAACRLLEECLKHQELDAFESLETKLLANVDTYQHPSALDPPRPSGQRDPIQLLGSYYLRHPARHVYVFEELTKLLTRGAVPPEWMVTTLWKKCVDKAIRSVSTEDRGYAAARRLIEAVILSSAGIYSSASPKMPPLANHRGQALRPVRPRETRASTTTSNLSNDQSLCPIPVQDALSNLVSSLLAALCGICIARSQAVDAVARSAGLKAREMVGDLAFTVQRAVGNETIILELEQAAFRPLRCGYVLLADCTLQCGQSGTPEVIYHCDSGSRRNIESFFKASASRQDVVRELARLVSQVFHHFGHTQDQGPVRTPYQIRARVSQLAQLTSTTGVALLLGKVAAETAMELAERTLDTDDHTWAVEVQEIVASSQQGETSQRSPSNSHSITSLYRWEDTIGEWVARTPAARPRAVTTAVAGKAQLKKHRRPRMVACSTSSSSASSICSEESVSSVTSSAPSPEPQTPVTAYAEKPQARRRGRPRIVSRTASTSRASSTCSEEGVSTEISSMSFEKPQVLNTGQRRRRGRPRLIASPANSLPAKSCLEDTSSVASSPASVSRKRPCVDRDSRSWPFKKTYHTRSSERVVSKGDNPTNDPDCSSYQPSSGATHVPAAAQTNTGLRDVLQKNPVGQGDATTRNTRMVPVPTLEVVIVNKSPSSNCAAASKHPMQPVKRRTRHSSITPRLSPRLPRRRQSVPARVTRRSLETVIPGPEDDSDDELSFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="105" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B3Q5</accession>
    <accession>C8VA99</accession>
    <name>Q5B3Q5_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Rhamnogalacturonase A/B/Epimerase-like pectate lyase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ANIA_04825</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF76692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_662429.1">
        <property type="nucleotide sequence ID" value="XM_657337.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B3Q5"/>
    <dbReference type="STRING" id="227321.Q5B3Q5"/>
    <dbReference type="CAZy" id="GH55">
        <property type="family name" value="Glycoside Hydrolase Family 55"/>
    </dbReference>
    <dbReference type="GeneID" id="2872623"/>
    <dbReference type="KEGG" id="ani:ANIA_04825"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN4825"/>
    <dbReference type="eggNOG" id="ENOG502SINF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002540_2_0_1"/>
    <dbReference type="InParanoid" id="Q5B3Q5"/>
    <dbReference type="OMA" id="AKCNGST"/>
    <dbReference type="OrthoDB" id="1046782at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd23668">
        <property type="entry name" value="GH55_beta13glucanase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000023">
        <property type="entry name" value="Exo-beta-1,3-glucanase Exg0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000043">
        <property type="entry name" value="Exo-beta-1,3-glucanase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039279">
        <property type="entry name" value="QRT3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024535">
        <property type="entry name" value="RHGA/B-epi-like_pectate_lyase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33928:SF2">
        <property type="entry name" value="PECTATE LYASE SUPERFAMILY PROTEIN DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33928">
        <property type="entry name" value="POLYGALACTURONASE QRT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12708">
        <property type="entry name" value="Pect-lyase_RHGA_epim"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010343000" description="Rhamnogalacturonase A/B/Epimerase-like pectate lyase domain-containing protein" evidence="4">
        <location>
            <begin position="21"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="domain" description="Rhamnogalacturonase A/B/Epimerase-like pectate lyase" evidence="5">
        <location>
            <begin position="170"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="Rhamnogalacturonase A/B/Epimerase-like pectate lyase" evidence="5">
        <location>
            <begin position="515"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBF76692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="900" mass="96579" checksum="25F70C88581680A3" modified="2005-04-26" version="1">MVRCRLVVLLGACILLQAIASPVLDADGLIAPRAAESPPEIAQNDVDNARHPLLVDATEASIDEARVVVKDAIARMTKLNKARLDNPILGSYKSGPGTNITRSGSENSPLLEITKEIAHAAALVAEADMAANLANGTSTLAQQAAGTFWMQDIRRQGTVPWGNDPAYKVFRNVVTDYHADPTGASDSTAAIQAAINDGNRCGARCNGSTRKNAIVYFPPGTYLVSSTIEANNWPTIKAASSFVGLGVLSTNQYVGGTGPDGGDGQYYVNTARFYSQIRNLRIDITATARDAYVCAIHYQIAQATSLQDVELIATTGTTQQGIFSENGSGGIMSDVTFRGGNFGFYGGNQQFSAHRMTFIGCATAVQIIWDWTWVWKSLDIQGAEVGLRLVSNDGSGNVGSVALIDSKLTSVNTAIIIAPASSTPGTGTTGLVLDNTRIDGPIVDTAGKVYLGAGYYDNWVLGPTYRGTTRTWSSAPFSSYPREQSLLGNRVDGLNNAPYFERKKNQYADRPVGDFVQLKSLGARGDGVTDDTAAVQRAFNEHGSGNKIIFVDSGTYILTDTVVVPKDAKIHGEAWSQFAASGSAFSDANNPRVMLQIGNRGDVGTVELQDLILTTKGGTAGAVLMQWNVKAASPGAAALWDVHARIGGAIGTSLTQTECPPLTTGTNPASCQAASLMLHLTPEASGYFENMWLWVADHLIDDLDLNDAYNDMPQLSVYVARGMLIESTSATWLYGTSSEHCVFYQYNFHHAQNIFTTVIQTEPPYYQPNPRPPAPFNNQVGKYSSDPAYNCNDANFNGCDEAWAVIITESQNIHIGSAGTYSWFSAYTQDCIDRHSCQQALWRLRNNHDNVRLQNVIGIGAEYVLVSDGAGVRSVDNLGVTAHPAWAQISIFDAPSHGRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B5C3</accession>
    <accession>C8V421</accession>
    <name>Q5B5C3_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ASST-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ANIA_04257</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF74378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_661861.1">
        <property type="nucleotide sequence ID" value="XM_656769.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B5C3"/>
    <dbReference type="STRING" id="227321.Q5B5C3"/>
    <dbReference type="GeneID" id="2873674"/>
    <dbReference type="KEGG" id="ani:ANIA_04257"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN4257"/>
    <dbReference type="eggNOG" id="ENOG502SI58">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018249_1_1_1"/>
    <dbReference type="InParanoid" id="Q5B5C3"/>
    <dbReference type="OMA" id="DDGHIIW"/>
    <dbReference type="OrthoDB" id="5427350at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053143">
        <property type="entry name" value="Arylsulfate_ST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039535">
        <property type="entry name" value="ASST-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35340:SF8">
        <property type="entry name" value="ASST-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35340">
        <property type="entry name" value="PQQ ENZYME REPEAT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14269">
        <property type="entry name" value="Arylsulfotran_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010161329" description="ASST-domain-containing protein" evidence="3">
        <location>
            <begin position="18"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="584"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="499"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="540"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBF74378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="632" mass="70972" checksum="162346EB6F15ABF9" modified="2005-04-26" version="1">MLFSAILLSLTFGRVFADAGDDDDLMSFVTLPKVRALKFEISYHDRQAVAPGYWFVAPYGIIEPEVPTKQWMPYQVGPYIYDGDGVLVWAGSPMFDNRNTFDFKAANNIDGESHLSFILQHQYHDDGTDKGYGYILDQHYEQEYKVGVVNDLSAFNMHEFNVLDGGKTALACLYKSEYSDLSALGRPQDFSWIIAGGLLELDTETGEVLFEWSSLNNVLVDESVKVSTDSYPSDRPGWDYIHVNSADKNSVGDYLLSARFANTIYYISKEGEIVWRLGGKFNDFDMDFTFSKQHHARFIESNGTHHVISFLNNASDELEAEEDVSSALYVQLDTTVSPMTARVIKRINRPDGGLTRLRGNVQTLPNGNTFVGWSERGYHSEHDPDGKLLMEAKFVSTRLSSYRSYKYPFTGRPNTPPDVVASVYGTEPADLTTIFHVSWNGATDIASWQFYARSSEDGLPVPVGSTVKTDFETMYIADGYLDWVSVEALDKEGNILGKSEVQRTQTPSNWRLAGFQGEEQPTPDDPAILYSTKEEKPDVGEEEEEEGKEEDMADMDMDMDMESEVDPNEAAKAAVQAYEMIRGVGGLLIFILVTCSLGGVLAAIYYCLRRRRTRSYHEIPLDEAERQPMAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="117" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B5X2</accession>
    <accession>C8V5I0</accession>
    <name>Q5B5X2_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">dihydroxy-acid dehydratase</fullName>
            <ecNumber evidence="14">4.2.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">ANIA_04058</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="20">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(2R)-2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:24809"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:49072"/>
            <dbReference type="EC" id="4.2.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:24810"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>(2R,3R)-2,3-dihydroxy-3-methylpentanoate = (S)-3-methyl-2-oxopentanoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:27694"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:49258"/>
            <dbReference type="EC" id="4.2.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:27695"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="13">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 3/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 3/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IlvD/Edd family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.9" evidence="14"/>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF74791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_661662.1">
        <property type="nucleotide sequence ID" value="XM_656570.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B5X2"/>
    <dbReference type="STRING" id="227321.Q5B5X2"/>
    <dbReference type="GeneID" id="2873477"/>
    <dbReference type="KEGG" id="ani:ANIA_04058"/>
    <dbReference type="eggNOG" id="KOG2448">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014271_4_1_1"/>
    <dbReference type="InParanoid" id="Q5B5X2"/>
    <dbReference type="OMA" id="DIERNAC"/>
    <dbReference type="OrthoDB" id="3851628at2759"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00057"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00061"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
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        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:dihydroxy-acid dehydratase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009082">
        <property type="term" value="P:branched-chain amino acid biosynthetic process"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
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        <property type="project" value="UniProtKB-UniPathway"/>
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        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.30.80:FF:000001">
        <property type="entry name" value="Dihydroxy-acid dehydratase"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="IlvD/EDD C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050165">
        <property type="entry name" value="DHAD_IlvD/Edd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042096">
        <property type="entry name" value="Dihydro-acid_dehy_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004404">
        <property type="entry name" value="DihydroxyA_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020558">
        <property type="entry name" value="DiOHA_6PGluconate_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056740">
        <property type="entry name" value="ILV_EDD_C"/>
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    <dbReference type="InterPro" id="IPR000581">
        <property type="entry name" value="ILV_EDD_N"/>
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        <property type="entry name" value="IlvD/EDD_N"/>
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    <dbReference type="NCBIfam" id="TIGR00110">
        <property type="entry name" value="ilvD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PRK00911.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21000:SF13">
        <property type="entry name" value="DIHYDROXY-ACID DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21000">
        <property type="entry name" value="DIHYDROXY-ACID DEHYDRATASE DAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24877">
        <property type="entry name" value="ILV_EDD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00920">
        <property type="entry name" value="ILVD_EDD_N"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF143975">
        <property type="entry name" value="IlvD/EDD N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00886">
        <property type="entry name" value="ILVD_EDD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00887">
        <property type="entry name" value="ILVD_EDD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dihydroxy-acid/6-phosphogluconate dehydratase N-terminal" evidence="17">
        <location>
            <begin position="78"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="Dihydroxy-acid/6-phosphogluconate dehydratase C-terminal" evidence="18">
        <location>
            <begin position="409"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00052865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF24877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CBF74791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="603" mass="63933" checksum="E7B7EE1C25C1B395" modified="2005-04-26" version="1">MDSTKPTDNPSLQDPKYIEFPALPSDAKHADGTLALNRHSTHITRGHDFPGAKAMLYAAGVPDKESMAKSPHVGIAGSTSSTHFADFPLTDKKAVIDRGMLGWQYNTIGVSDAISMGSEGMRFSLQSREIIADSVETVTCAQYHDACIAIPGCDKNMPGVVMGMARHNRPSLMIYGGTIQKGYSQSLRKNISVSSCFEAAGAYAYDTLRQPDDGGDTSLTKDEIMDDLEKHACPSAGACGGMFTANTMATAIESMGLTLPGSSSTPASSPTKMRECVKAADAIKTCLEKNIRPRDLLTKRSFENALVMTMALGGSTNGVLHFLAMARTAGVDLTLDDVQRVSNKIPFIADLSPSGKYFMADLYEIGGIPSVHKLLIAAGLIDGGIPTVTGKTLAENVASYPSLPDDQVIIRPLNNPIKPTGHLQILKGNLAPGGAVAKITGKEGTKFTGKARVFDKEYQLNDALTQGKIPRGENLVLIVRYEGPKGGPGMPEQLKASAALMGAKLTNVALITDGRYSGASHGFIVGHIVPEAAVGGPIAVVRDGDSVTINAETNELSMDVSDEEIQRRLKEWKPPAPTVTRGVLAKYARLVGDASHGAMTDLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="107" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B5X5</accession>
    <accession>C8V5I3</accession>
    <name>Q5B5X5_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Acid phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ANIA_04055</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.2"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.1.3.2" evidence="2"/>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF74797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_661659.1">
        <property type="nucleotide sequence ID" value="XM_656567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B5X5"/>
    <dbReference type="STRING" id="227321.Q5B5X5"/>
    <dbReference type="GeneID" id="2873478"/>
    <dbReference type="KEGG" id="ani:ANIA_04055"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN4055"/>
    <dbReference type="eggNOG" id="ENOG502QSRP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027977_2_0_1"/>
    <dbReference type="InParanoid" id="Q5B5X5"/>
    <dbReference type="OMA" id="EHIPYAG"/>
    <dbReference type="OrthoDB" id="5135119at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009395">
        <property type="term" value="P:phospholipid catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000043">
        <property type="entry name" value="Acid phosphatase PHOa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007312">
        <property type="entry name" value="Phosphoesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31956:SF8">
        <property type="entry name" value="ACID PHOSPHATASE PHOA (AFU_ORTHOLOGUE AFUA_1G03570)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31956">
        <property type="entry name" value="NON-SPECIFIC PHOSPHOLIPASE C4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04185">
        <property type="entry name" value="Phosphoesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010237712" description="Acid phosphatase" evidence="6">
        <location>
            <begin position="18"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="386"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00072210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBF74797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="406" mass="45388" checksum="BDFA16F34B62E147" modified="2005-04-26" version="1">MKSSLVILLGAVASTVAQTATTTEPSLSDIAASAATIEPYSPVSNVEGLAFQRIFQVWFENIDYEDAAANENLQWLAKQGIVLSNFYAVTHPSQPNYCAAAGGDTFGMDHDDFLRIPANVSTVVDLLDTKYIAWAEYQEHMPYPGFEGFNYSNQETYADDYVRKHNPLILYDSVAENDMRRRQIKNFTHFDDDLASEKLPQWAFFTPNMTNDAHDTNITFAANWLRGWISPLLENDYFMNDTLILITFDEDKTFPKDNRIFSILLGGAVPENLHGTEDNTFYTHYSVIASVSANWGLPSLGRWDCGANILEIVANKTGYVNYKVDTTNLRLNQTYPGPLSNGDLSEYSPVWPNPLTEGDCSAGHGILDTVKETYAGTQPTYNYTSPFPYDSKSGYNEDVDATRKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="130" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B697</accession>
    <accession>C8V643</accession>
    <name>Q5B697_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">DNA-directed RNA polymerase subunit beta</fullName>
            <ecNumber evidence="13">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">ANIA_03933</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="21">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:21249"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="13"/>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF75062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_661537.1">
        <property type="nucleotide sequence ID" value="XM_656445.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B697"/>
    <dbReference type="FunCoup" id="Q5B697">
        <property type="interactions" value="921"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5B697"/>
    <dbReference type="GeneID" id="2873357"/>
    <dbReference type="KEGG" id="ani:ANIA_03933"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN3933"/>
    <dbReference type="eggNOG" id="KOG0216">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000524_5_1_1"/>
    <dbReference type="InParanoid" id="Q5B697"/>
    <dbReference type="OMA" id="FFGVVHY"/>
    <dbReference type="OrthoDB" id="10248617at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006363">
        <property type="term" value="P:termination of RNA polymerase I transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006361">
        <property type="term" value="P:transcription initiation at RNA polymerase I promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00653">
        <property type="entry name" value="RNA_pol_B_RPB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.270.10:FF:000011">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.150:FF:000004">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1100.10:FF:000008">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1100.10:FF:000016">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1110.10:FF:000007">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1800.10:FF:000007">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="2.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1070.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.270.10">
        <property type="entry name" value="DNA-directed RNA polymerase, subunit 2, domain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1800.10">
        <property type="entry name" value="RNA polymerase alpha subunit dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1110.10">
        <property type="entry name" value="RNA polymerase Rpb2, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015712">
        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007120">
        <property type="entry name" value="DNA-dir_RNAP_su2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037033">
        <property type="entry name" value="DNA-dir_RNAP_su2_hyb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007121">
        <property type="entry name" value="RNA_pol_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007644">
        <property type="entry name" value="RNA_pol_bsu_protrusion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007642">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037034">
        <property type="entry name" value="RNA_pol_Rpb2_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007645">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007641">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014724">
        <property type="entry name" value="RNA_pol_RPB2_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009674">
        <property type="entry name" value="Rpa2_dom_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06883">
        <property type="entry name" value="RNA_pol_Rpa2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04563">
        <property type="entry name" value="RNA_pol_Rpb2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04561">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04565">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00562">
        <property type="entry name" value="RNA_pol_Rpb2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04560">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01166">
        <property type="entry name" value="RNA_POL_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 13 20" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RNA polymerase beta subunit protrusion" evidence="17">
        <location>
            <begin position="40"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="16">
        <location>
            <begin position="230"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="18">
        <location>
            <begin position="499"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase I subunit RPA2" evidence="19">
        <location>
            <begin position="603"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase subunit 2 hybrid-binding" evidence="14">
        <location>
            <begin position="709"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="15">
        <location>
            <begin position="1091"/>
            <end position="1138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF04560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF06883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CBF75062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="1231" mass="138243" checksum="7789CD9818F2EF50" modified="2005-04-26" version="1">MAPAATDTNWSVNYDVLKRENLFRNPPQDKTAYPSLAESIKPHVDSFNALFEKGGIIEAGLKDIGTRTFLDEVVETAEQKQQRLAEGRRAPRRNKLHVRIKEVFLEKPTIPLTNKYTARNRNIYPSECRERHATYRGKLRAKIEYRVNNGDWTEQVRELGQVPIMLRTNRCYLEKATPAELVQHKEESEELGGYFIVNGNEKLIRMLIVGRRNYPMAIVRNTFTNRGHAYSKFGIQIRSVRPDQTSQTNVLHYLNDGNVTFRFSWRKNEYIIPVVMILKALVETNDREIFEGIVGSASSEGINNTFVTDRVELLLRTYKAYKLHSRSECRAFIGEKFKPVLGVPADTPNEEAGTEFLRKVVLPHLGNQNVTETQDYDKFKMLMFMIRKLYALVAGDCAPDNPDAVSNQEILLGGFLYGMLLKERLDEWVRSFGPILRDWSNRNHGARFTDPAFERDFVSKVIRRSNENIGGAMEYFLSTGNLVSPTGLDLQQTSGYTVMAEKINFYRFISHFRMIHRGSFFAQLKTTTVRKLLPESWGFLCPVHTPDGSPCGLLNHLAHKCLVATSDTDVSHLPKLLVQLGVRNESSVSLDESVTVQLDGRIIGYCSPKQARVIASTLRHWKVSGTNNVPLGLEIGYVPNSNGGQYPGIYMFSQAARMYRPVKYLPLDKLDYVGPFEQPFMEIACLPSDLVKGLSTHIEFTPTNILSIVANMTPFSDYNQSPRNMYQCQMSKQTMGTPGTAIDYRTDNKLYRLQTGQTPIVRPPLYNAYGLDNFPNGTNAVVAIISYTGYDMDDAMIINKSSHERGFGYGTVYKTKVHSLDEKDSRRTKSKQAVQKLFGFAPGSEIRAEWRATLDEDGFPHIGAEIKEGSIVAAYHTVRYDATSDSYINVDGITHFVKYKDSERAYIDSIRIMGSETGTEPAQAISVKYRIPRKPIIGDKFSSRHGQKGVCSQLWPAVDMPFSESGIQPDLIINPHAFPSRMTIAQMIESMAGKAGALHGHPQDCTPFQFSEEYTATDYFGEQLRRAGYNYYGNEPLYSGITGKEFAADIFIGVVHYQRLRHMVNDKFQVRTTGPVNNLTGQPVKGRAKGGGIRVGEMERDSLIAHGAAYILQDRLMNCSDSQRAWICRDCGSFLSTQVAVSSAGSSKARMAAKNSSGSAALGGNAGIVRCRRCAREAVFDDSRAVVWEDGEGRRFVGGDNVTVVAVPGVLRYLDVELAAMGIRMKFRVDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="104" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B703</accession>
    <accession>C8V7N5</accession>
    <name>Q5B703_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Asparagine synthase related protein (AFU_orthologue AFUA_4G12480)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ANIA_03677</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF75632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_661281.1">
        <property type="nucleotide sequence ID" value="XM_656189.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B703"/>
    <dbReference type="FunCoup" id="Q5B703">
        <property type="interactions" value="713"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5B703"/>
    <dbReference type="GeneID" id="2873099"/>
    <dbReference type="KEGG" id="ani:ANIA_03677"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN3677"/>
    <dbReference type="eggNOG" id="KOG0573">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012368_2_0_1"/>
    <dbReference type="InParanoid" id="Q5B703"/>
    <dbReference type="OMA" id="SVYESCP"/>
    <dbReference type="OrthoDB" id="10252281at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01991">
        <property type="entry name" value="Asn_synthase_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03766">
        <property type="entry name" value="Gn_AT_II_novel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051857">
        <property type="entry name" value="Asn_synthetase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45937">
        <property type="entry name" value="ASPARAGINE SYNTHETASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45937:SF1">
        <property type="entry name" value="ASPARAGINE SYNTHETASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0061">Asparagine biosynthesis</keyword>
    <keyword evidence="3" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="4">
        <location>
            <begin position="2"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBF75632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="592" mass="65254" checksum="E2310D2377B58B16" modified="2005-04-26" version="1">MCGIFFSLTAAENPVLLDRDLRYLLTKRGPDEGSYSIGVRGAGLNLFNHEGNGRMWLSFASTVLSMRGDDVVRQPLTDSGRTGSILAWNGDAWKIDGQPIPEKNDTEIVFNHLLQATTQDYLAEDYTGVSNPVQRVADAISKITGPFAFVFYDAVNFRLYFGRDCLGRRSLLWGLDAAGNLTICSLSDASSPSSFQEVEADGIYMIEFQDDQSADPEPAPAAGPLCFDVKNIQRIPWSHEALPKYHMISPIPPMNKAIPEGTPSQLTVTSSVLRELEDRLRQSLALRIQNVREPPLAGGSNVKIAVLFSGGLDCTLLARLAHDILPPGETIDLLNVAFENPRVVAAAAKGLGQRSSAYEGCPDRITGRAAFAELQRVCPSRNWRFVAVDIPYVVTITHRDTIKRLMRPHNTEMDLSIACALYFAARGQGTAIDSQRPDARPFQYKTPARVLLSGLGADELFAGYSRHGIAFSRNGYRGLINEIELDVSRLGKRNLGRDNRVIAHWGREARFPYLDEDFVAWVVRTPVWEKCGFGVPGAPIDAGIDSEKKTLRLLALKLGLENVSREKKRAIQFGSRTAKMEKGKTKGTDALD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B7Y8</accession>
    <accession>C8VHU9</accession>
    <name>Q5B7Y8_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ANIA_03342</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF82907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_660946.1">
        <property type="nucleotide sequence ID" value="XM_655854.1"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5B7Y8"/>
    <dbReference type="GeneID" id="2874016"/>
    <dbReference type="KEGG" id="ani:ANIA_03342"/>
    <dbReference type="eggNOG" id="ENOG502SJ79">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001466_3_0_1"/>
    <dbReference type="InParanoid" id="Q5B7Y8"/>
    <dbReference type="OMA" id="TWCIRLG"/>
    <dbReference type="OrthoDB" id="2913095at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031350">
        <property type="entry name" value="Goodbye_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042621">
        <property type="entry name" value="TTC23/TTC23L"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14485:SF2">
        <property type="entry name" value="FUNGAL STAND N-TERMINAL GOODBYE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14485">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17109">
        <property type="entry name" value="Goodbye"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Fungal STAND N-terminal Goodbye" evidence="3">
        <location>
            <begin position="16"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="4">
        <location>
            <begin position="293"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="255"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBF82907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="1480" mass="167874" checksum="19748FAE13F89618" modified="2005-04-26" version="1">MSQTKNTAPASVQEIWENTIARFHQRTGQQLNGVSRTTEDLRRALAAHYAAQVDDEDISRAKETGFKIIRCIQLLGGIAAEGASLVFGPAGLCFNALSFLLDIPKTVHEFHGEINAIFAEVGPALAQFRIYQRMEETMSVDEALRASIDQVMTSFVDICANCINIHREGRWRSFKRSAKRILLDEGSVRDELDNFKKLTQNQLNVQATLTLEVALETNQGVAFIKSSVTEIDTTAKGIKTDVSGLVEAEHKRGLNDARKKSLKTIRENLAQKEEETANVIDAREKMWKNSVKGSGKWLNNIDEYKQWLDRSSTSNSLLVLTGGPGTGKSFLVSAIAQDVKSRNSATKAERGLLGYYSFSISNKADSDRNRPETAIKSICTQMAEQDAVYARHVAGVCEESGKDKNYFKDATCQTLWTALGLGSPVRNAMHYILLDSVNILSEEELKRLFEMIEKRPALSDEDKSNPVRILISCERSVLQDEWLNSVSAMCIDITRYNAEDISTFIVEDLKRADLFQGHDQDSQRRRKMVGDRLLKRSNKCYTTVQQDLGKIKAIVASSGTEEELNRVLQESSTDPKAVVRSELETLESVLNPREIEEVNELLIWVIAGNVYLSIDELASALYLRFKTVSLQPLAQKIAGKYSKIFDLSYGGNTVILRDHVEEYVVAERVRPRQSVDDPKISATITITNGDRKAVQRFFWDLTHHSSFANGFEFRPESDLSQVPNRKFQVYMVDAHFEIVKRAFEYFLLPQGEEKEGGRLIGMYMLSSIPGHLEALYNAQGLDELPVADKQYIGSRVYDMFNECDLIERNWDLCKWTNWYSMDHEMEIFWKWLDNPVAIARLGARDKRWLSEIRKDKYPNRSLLTPIMTMVARNWLQKTEWNVQTPFEWLSGFLSLGANSALKQDDVAAEEAGTKTQPVEKTGEDDEIMISQTDSEVEKVVQAENWAKKALGISEVDCTWCIRLGETYKALWEREAAMEQYKKAVVILQNQDAVDKERLASIFQALGELEDSVDNLESAISYYKQAYEQNGPNKDILHALASDYALTGLKEEAVSIVQQAVTEKTPGTESSLLIAMLQTVVRKDWAHLEPLFTAIHWLIVSSPEYWTVILQELEMAIEQNRAENKGEDVASLQLMLGNAMYFLRQNFPEDLVKAVDYWHAGLAILHEEIGLEGRWDLDFMKQQTLTLLGRRRVEQALQEEQPDYQCYTSELQELYETGEAYPSVKLVLASLYTLSGQRLKAQEILRSEMVTAFNILVDDDDGNDWEGFSAIRNSLMHTEDFENARKACLLLPERKFDLGVLKALLENEDPSLEAASTHLVEFYEKECQSDQTAMDRFNKVAEETERLRAAAEPNSTEAALWTGVSRILEGFHKLDDLPFPCKACWKRGVGLNFCKYCDRIDLCDACLADLQAGKASKPFVCSKLHDWIRFESWTLENYVLAWKRLVPVTAADGSQQLISASKWLGNLCDDWKLDKSEWGFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B8D3</accession>
    <accession>C8VIB4</accession>
    <name>Q5B8D3_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductase</fullName>
            <ecNumber evidence="3">1.1.1.302</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">ANIA_03197</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes an early step in riboflavin biosynthesis, the NADPH-dependent reduction of the ribose side chain of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, yielding 2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + NAD(+) = 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27274"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58890"/>
            <dbReference type="ChEBI" id="CHEBI:59545"/>
            <dbReference type="EC" id="1.1.1.302"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + NADP(+) = 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27278"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58890"/>
            <dbReference type="ChEBI" id="CHEBI:59545"/>
            <dbReference type="EC" id="1.1.1.302"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HTP reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.302" evidence="3"/>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF83211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_660801.1">
        <property type="nucleotide sequence ID" value="XM_655709.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B8D3"/>
    <dbReference type="STRING" id="227321.Q5B8D3"/>
    <dbReference type="GeneID" id="2873919"/>
    <dbReference type="KEGG" id="ani:ANIA_03197"/>
    <dbReference type="eggNOG" id="ENOG502SBB8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043966_4_2_1"/>
    <dbReference type="InParanoid" id="Q5B8D3"/>
    <dbReference type="OMA" id="DCMIMGR"/>
    <dbReference type="OrthoDB" id="3192019at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="entry name" value="Dihydrofolate Reductase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050765">
        <property type="entry name" value="Riboflavin_Biosynth_HTPR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38011:SF11">
        <property type="entry name" value="2,5-DIAMINO-6-RIBOSYLAMINO-4(3H)-PYRIMIDINONE 5'-PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38011">
        <property type="entry name" value="DIHYDROFOLATE REDUCTASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_8G06820)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="Dihydrofolate reductase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0686">Riboflavin biosynthesis</keyword>
    <feature type="domain" description="Bacterial bifunctional deaminase-reductase C-terminal" evidence="11">
        <location>
            <begin position="12"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="31"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CBF83211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="210" mass="23062" checksum="FBDA67641EFACA6B" modified="2005-04-26" version="1">MPPHTRTWKARVFAATSLDGAIARRDHDVSWLTQPEPNPAHKAPTHSAARSTPSTEQHAAEVDFMVMGRRTFEVCIGFPEWPYPAKKLLVLSATSAASACKLLNHESGSAITEHLQHVRVVASPEEADRILTEEGASLVYVDGGKTVQEFLRRGWVDEMVLTLAPVLLGGDEGRPRLFGDLPADIRFTLCGVDVIENGMLRLYTLGQPQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B8D7</accession>
    <accession>C8VIB8</accession>
    <name>Q5B8D7_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7703 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ANIA_03193</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF83219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_660797.1">
        <property type="nucleotide sequence ID" value="XM_655705.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B8D7"/>
    <dbReference type="GeneID" id="2874442"/>
    <dbReference type="KEGG" id="ani:ANIA_03193"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN3193"/>
    <dbReference type="eggNOG" id="ENOG502SIDK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045148_2_0_1"/>
    <dbReference type="InParanoid" id="Q5B8D7"/>
    <dbReference type="OMA" id="IMYELIA"/>
    <dbReference type="OrthoDB" id="405906at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056120">
        <property type="entry name" value="DUF7703"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37013:SF5">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37013">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_1G05950)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24802">
        <property type="entry name" value="DUF7703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="25"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="120"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7703" evidence="3">
        <location>
            <begin position="24"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBF83219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="329" mass="37679" checksum="FF970AA6B9BA728C" modified="2005-04-26" version="1">MGTDLTQPPDGLIGGYKGDNASVKIVVVTFITLAIYNAVELVILILFTFQRYHGLYFWTMLLSGVMGVIPHSVGYLLEFFDVGPRWLGVAISTFGFYFMVPGQSVVLWSRLHLVVQNRKLLHFVLWLIIVDAIILLIPTTVLTFSTIYVRIRPIIVGYNVMERLQVAWFCAQEIFISSIYIWETAKLLRLRPEKNARRTRVLYELLAINLIIIAMDVTLLVLEYRGMWYLQTTLKAAVYSIKLKLECGVLRKLVEIVQPTRQDTSSTEQDSFPTFVNPEYIVGDVTHAAPPQRNDRDRIQYPWRTSTDSFSLSDRRRPVSISSALSRPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B8W5</accession>
    <accession>C8VIV8</accession>
    <name>Q5B8W5_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Vacuolar protein sorting-associated protein 51 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ANIA_03015</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN).</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the Golgi-associated retrograde protein (GARP) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the VPS51 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF83562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_660619.1">
        <property type="nucleotide sequence ID" value="XM_655527.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B8W5"/>
    <dbReference type="STRING" id="227321.Q5B8W5"/>
    <dbReference type="GeneID" id="2873714"/>
    <dbReference type="KEGG" id="ani:ANIA_03015"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN3015"/>
    <dbReference type="eggNOG" id="KOG2346">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043566_0_0_1"/>
    <dbReference type="InParanoid" id="Q5B8W5"/>
    <dbReference type="OMA" id="YNLKPPG"/>
    <dbReference type="OrthoDB" id="203678at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000938">
        <property type="term" value="C:GARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014812">
        <property type="entry name" value="Vps51"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15954">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 51 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15954:SF4">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 51 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08700">
        <property type="entry name" value="VPS51_Exo84_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="2" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="2" id="KW-0653">Protein transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="20"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU368010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBF83562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="291" mass="32046" checksum="0755018BEE3F2F40" modified="2005-04-26" version="1">MSTISSPRPSIASSRAYSPTPASSRRPSLDALNTSIAGSLSATSTPSTARAVSPSLHPRRNRAALRDYYNLKPSDAAGLGPNGRRSRSVPRHTDAGDISNPSTVVAGTELDSPDFDPQRYVNNLLATSSLATILKAENTLVGDIRTLDGERKALVYDNYSKLIRAVETIGKMRQSMDERGAPLTMTKTLGPAISFVAETAGSLIREGEVLRERMRESNPVRERERREKETVRWVLEAPGRLAKLVEDGKREEAEKDWEEVRRLLEKWEGVKGVAEVRTACEKAMQKEDEAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="112" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B8Z3</accession>
    <accession>C8VIY7</accession>
    <name>Q5B8Z3_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short-chain dehydrogenase/reductase family protein, putative (AFU_orthologue AFUA_3G08550)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_02987</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF83614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_660591.1">
        <property type="nucleotide sequence ID" value="XM_655499.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B8Z3"/>
    <dbReference type="STRING" id="227321.Q5B8Z3"/>
    <dbReference type="GeneID" id="2874529"/>
    <dbReference type="KEGG" id="ani:ANIA_02987"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN2987"/>
    <dbReference type="eggNOG" id="KOG1208">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_44_4_1"/>
    <dbReference type="InParanoid" id="Q5B8Z3"/>
    <dbReference type="OMA" id="VESHGKC"/>
    <dbReference type="OrthoDB" id="542013at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF22">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE PHMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF83614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="337" mass="36931" checksum="18120424CE34C5A7" modified="2005-04-26" version="1">MAGLIRLLRTQFIPPTEPSISFAGKTVVLTGATAGLGFEAAIKMLNLGVESLIIGSRNLQRGEATKTELEQRTNRLGVVQVWELEMSSFQSVKDFAARVESLKQLDVALLNAGIWNREFTTSTEGWEETLQVNTLSTSLLALLLLPKLRSCSTDSSPTHLTVVSSQQFVRVQAKSLRTDGPLLEHLNDARRFSGPKQYGVSKLLLEYVLKSVAAQLHNENGTVPVVVNTVSPGLCVSSLGRQYTGLHHRLVVWIMYKLFARTAEQGSRSLVSATYQGLESHGRRWRSDGYLDESTALTTGAEGKQFQAKAWKEIMAVLKEQSNLAVVLDSNTGVSAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="117" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B922</accession>
    <accession>C8VJ20</accession>
    <name>Q5B922_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">MFS sugar transporter, putative (AFU_orthologue AFUA_5G06720)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ANIA_02958</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF83672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_660562.1">
        <property type="nucleotide sequence ID" value="XM_655470.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B922"/>
    <dbReference type="GeneID" id="2874024"/>
    <dbReference type="KEGG" id="ani:ANIA_02958"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_3_1"/>
    <dbReference type="InParanoid" id="Q5B922"/>
    <dbReference type="OMA" id="ISSNWIW"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000497">
        <property type="entry name" value="Putative MFS sugar transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="MFS_dom"/>
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        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF72">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="269"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="299"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="331"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="361"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="406"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="429"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="12"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="495"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="506"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CBF83672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="520" mass="58123" checksum="AC430BA252916D20" modified="2005-04-26" version="1">MFGRGRSLQAAIWTACGMAFILFGYDQGVFSGIVENENFLDHMSHPNDSLMGIIVSIYNLGCFTGCVVNFLVADKLGRRRAMWFAMLWVIVGATLQASAFSVPHMMVGRFVTGIGTGIETSTVPMWQAELCEASKRGKLVCSEPLLVGVGIVISYFFDYGMSFVGGQIAWRLPIACQMLFALVVIILIFGVPESPRYCYQKGHNEQALQILSDVYGKPKDDPKIQAEQTEILEALAVETKNGEYKWRNILKPDSVSTGRRVLLGYGMQFMNQVGGINLIVYFIPTVLHDNVGLTRNLSMIIGGCVQIMFVLGSFFPTFFVDRVGRRAPMMWGSFTLGVCMMMVSILLSFKGKENEHATSSASVAFFFVYMFAFGASVNCIPWVYVPEILPLHARAKGTAVGISSNWIWLKNFFVVMITPVIINRLQWKAYLIFMCTNFAFVPLVYFCYPETANFTLEEIDYLFTHREKGAVKLSKELHKERKKFGHARRLTADDSDALGTGVKGSELVEKSPTDEHVENV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B972</accession>
    <accession>C8VJ75</accession>
    <name>Q5B972_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ANIA_02908</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF83771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_660512.1">
        <property type="nucleotide sequence ID" value="XM_655420.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B972"/>
    <dbReference type="GeneID" id="2873951"/>
    <dbReference type="KEGG" id="ani:ANIA_02908"/>
    <dbReference type="HOGENOM" id="CLU_1768024_0_0_1"/>
    <dbReference type="InParanoid" id="Q5B972"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF83771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="147" mass="16281" checksum="97E6BD4CBD0BFB31" modified="2005-04-26" version="1">MELRFRYLVCRWMGKTNNTEKKCWDTGPHSTPLHKGSSQALLVHCLSQDWTDESAYVKWENVAGKDRIKPEKKEKSDILLSELVLESIGSGLRQFDERVHILATSTVGPETSSLSSCLGAFLIGTGVLTTGEAKAPGELTFDPVTDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BA60</accession>
    <accession>C8VPV7</accession>
    <name>Q5BA60_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7703 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ANIA_02570</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
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            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
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        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF87118.1"/>
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        <property type="nucleotide sequence ID" value="XM_655082.1"/>
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        <property type="component" value="Chromosome VII"/>
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    <dbReference type="InterPro" id="IPR056120">
        <property type="entry name" value="DUF7703"/>
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        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
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            <end position="45"/>
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    <feature type="transmembrane region" description="Helical" evidence="2">
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    <feature type="transmembrane region" description="Helical" evidence="2">
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    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="161"/>
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    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="203"/>
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    <feature type="domain" description="DUF7703" evidence="3">
        <location>
            <begin position="20"/>
            <end position="245"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="293"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBF87118.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="326" mass="36426" checksum="CFB69E05D804CBFE" modified="2005-04-26" version="1">MDLNTPPFGLEHGLESANIALRMTAAAFLCLALFNSLELVLLVCWTFHQRRGLYFWSLLISSIGIIPYVVGTILHNFDLVPLAVSLPIGHVGFICIVPVQSLILYSRLHLVFYHEKILRIMLFVIITVSIVLIVPNSVSMYGSAFTTSPSWNYSYNVTERLQVTGFAIQELLLSLFYVYSAVLLLRISPEGKSRVKRIMYELLWINTLTIVLDIAVVCLKVFVYSVKVKLELAVLGRLVALTNTTQEKRRNTVRRASFIGPTYDLSDFTNTNDAPIGTDTDRGPVAVGIEEVERPSTGSITEPTPGNADRRSANALAQRIHWDSHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="116" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BAB4</accession>
    <accession>C8VPJ6</accession>
    <name>Q5BAB4_EMENI</name>
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        <submittedName>
            <fullName evidence="9">Actin-associated protein (Eurofung)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ANIA_02516</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF87010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="evidence" value="ECO:0000318"/>
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        <property type="entry name" value="SH3_domain"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="SH3DOMAIN"/>
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    <dbReference type="SMART" id="SM00721">
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <location>
            <begin position="17"/>
            <end position="265"/>
        </location>
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    <feature type="domain" description="SH3" evidence="7">
        <location>
            <begin position="349"/>
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    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="274"/>
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    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="149"/>
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        <location>
            <begin position="288"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="320"/>
            <end position="334"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBF87010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="408" mass="46397" checksum="87EB8B708A0EE416" modified="2005-04-26" version="1">MSLKGFQKSIVRAPQTFKARFNIGDNTKDPVYTDAERRFQELEKETKKLHDESKKYFDAVNGMLDHQIEFSKAMTELYKPISGRASDPSTYTIEGNPEGIRACEEYEVIVQDLKEALAPELEMIDSRVVSPAQQLLEVIKAIRKVAVKRDHKKLDYDRHRNTLKKLQDKKDKSLKDEKALYKAEGDVEQATQEYNLYNDLLKDELPKLFALEAEFIRPLFQSFYYMQLNVFYTLHEKMQGINIGYFDLTRDIEEAYEEKRGDVKERAEELTIVHFKTTGGRRPGSKLTGKDKLAAEHKGRFGSRPSDPDVVENPPPPYSPGASGSALAAAAAKKPAPPPPKPKPSQFRAPVETVTALYDYEAQAHGDLSFSAGDVIEIVQRTDNQNEWWTGRVDGREGQFPANYVQLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="107" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BAT3</accession>
    <accession>C8VNF0</accession>
    <name>Q5BAT3_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ANIA_02347</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF86660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_659951.1">
        <property type="nucleotide sequence ID" value="XM_654859.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BAT3"/>
    <dbReference type="GeneID" id="2875103"/>
    <dbReference type="KEGG" id="ani:ANIA_02347"/>
    <dbReference type="eggNOG" id="KOG0156">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_677974_0_0_1"/>
    <dbReference type="InParanoid" id="Q5BAT3"/>
    <dbReference type="OrthoDB" id="1055148at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF4">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_7G04540)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBF86660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="406" mass="44910" checksum="828BA73CD597C609" modified="2005-04-26" version="1">MRPSEKWWRQYGHSVFQIRLANTRVVVVKSFDDCRKMLLSHQNALIDRPKLYTSYCVISSTQGYTIDSSPWDEPCRKKRKAAGTALGRPALRNYHPPYVRSGELLHFTDLYRDSKDGEAEVSVRPYLQRYALNTTLTLCYGIRMDEVTTKFSVRSCTLVRQYLSCTAQLRIYKITSRFSGYMDGCRDGGEGDLYQCDHQGGSAVLYCQLDEFAAQEVTEINWNGAIIPPKTMILINAQAGNRDLFSIKAHVAVVTGGSSGIGPMVAKLKVIGFIGIMTNGARVHIVALPTDPIDETVSDLTSWGSASSGGSAQGYACNLSSKSALLELASYISKAKGGKLDILISNAGTRRDPPVECNVFTAPLFELQESMFSRTEHDWENTFSVKTTAHYFLCVDLLPSLAAATD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BAU1</accession>
    <accession>C8VND9</accession>
    <name>Q5BAU1_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_02339</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF86639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_659943.1">
        <property type="nucleotide sequence ID" value="XM_654851.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BAU1"/>
    <dbReference type="GeneID" id="2874932"/>
    <dbReference type="KEGG" id="ani:ANIA_02339"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN2339"/>
    <dbReference type="HOGENOM" id="CLU_1686545_0_0_1"/>
    <dbReference type="InParanoid" id="Q5BAU1"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF86639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="156" mass="17196" checksum="559E6410C9E2BA5F" modified="2005-04-26" version="1">MPEMSHQGSSLFWHNQDYKSLSKNGSERIPKPTKPSSATDSGPERWPPSARPPSHTVFTRRIQPYSIHGYSGIDRAVSTVATPPMRGPGASIIGRGPVTRLAEQGTSISVCMESEYVTLSRSSNKAWSQQRSPNPRALSQMIYAVRGLLQSWDIKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="107" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BAZ8</accession>
    <accession>C8VN29</accession>
    <name>Q5BAZ8_EMENI</name>
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        <submittedName>
            <fullName evidence="9">MFS transporter, putative (AFU_orthologue AFUA_5G06290)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ANIA_02282</name>
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    <organism evidence="9 10">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF86527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_659886.1">
        <property type="nucleotide sequence ID" value="XM_654794.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BAZ8"/>
    <dbReference type="GeneID" id="2875517"/>
    <dbReference type="KEGG" id="ani:ANIA_02282"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_0_1_1"/>
    <dbReference type="InParanoid" id="Q5BAZ8"/>
    <dbReference type="OMA" id="GFTTMMQ"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000034">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000068">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF46">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="154"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="216"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="287"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="327"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="351"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="381"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="414"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="445"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="56"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBF86527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="503" mass="56304" checksum="ACB4A08388F9A062" modified="2005-04-26" version="1">MGVLDRETEGSKNSRSPSREKADEVQMGLESPQPGELPLLTATTERKLMAKVDWHVVPCLCIMYLLAFLDRVNISNAAALGLKDDLNIAEGTKYNTALTIFFVPYVLFEIPSNILLKKLRPHVWLSLCMFTFGVVTICQGLVTNWGGLMTTRWFLGMSETGMFPGCFYLLGMWYKRSEAQKRFSFFFSSTSLAGAFGGVLASGLGKMHGVRNLAGWRWVFLIEGVLTAVVAIILFFFLPDFPEEAKWLTEEERAYMRAKLAQDSGEAGEDTRMGWREVLAVFKDYKIFIGGLMYFGQIVTAYGYAYFAPTIIQSYGYGPIQTQLYSIPPWAGAFGFSMCIAYISDKFRHRFAFTIIPMLISMAGLGILMNVHDNRDVQYGALFLVTAGCYSAMPVVVCWYAMNLGGHRRRSVGTAWQVGFGNIGGIIATYSFLAKDRTNNYYTGFSIGISFLAFSCACCCVYFAAVWHQNQKKDRILASGDPSYLEEDEAVLGDQATKFRYAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BB54</accession>
    <accession>C8VML8</accession>
    <name>Q5BB54_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">THO complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ANIA_02226</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the THOC2 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF86420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="XP_659830.1">
        <property type="nucleotide sequence ID" value="XM_654738.1"/>
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        <property type="interactions" value="600"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5BB54"/>
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    <dbReference type="KEGG" id="ani:ANIA_02226"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN2226"/>
    <dbReference type="eggNOG" id="KOG1874">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000511_1_0_1"/>
    <dbReference type="InParanoid" id="Q5BB54"/>
    <dbReference type="OMA" id="QERWTCI"/>
    <dbReference type="OrthoDB" id="29024at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000445">
        <property type="term" value="C:THO complex part of transcription export complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="InterPro" id="IPR040007">
        <property type="entry name" value="Tho2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021418">
        <property type="entry name" value="THO_THOC2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021726">
        <property type="entry name" value="THO_THOC2_N"/>
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    <dbReference type="InterPro" id="IPR032302">
        <property type="entry name" value="THOC2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21597:SF0">
        <property type="entry name" value="THO COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21597">
        <property type="entry name" value="THO2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11262">
        <property type="entry name" value="Tho2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11732">
        <property type="entry name" value="Thoc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16134">
        <property type="entry name" value="THOC2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="THO complex subunit 2 N-terminal" evidence="9">
        <location>
            <begin position="173"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="domain" description="THO complex subunitTHOC2 N-terminal" evidence="8">
        <location>
            <begin position="910"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="domain" description="THO complex subunitTHOC2 C-terminal" evidence="7">
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            <begin position="1272"/>
            <end position="1577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
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            <begin position="580"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
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            <begin position="619"/>
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    <feature type="region of interest" description="Disordered" evidence="6">
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            <begin position="1200"/>
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    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1594"/>
            <end position="2429"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="1295"/>
            <end position="1347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
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            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
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            <begin position="36"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
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            <begin position="58"/>
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            <begin position="85"/>
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            <begin position="1226"/>
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            <begin position="2006"/>
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            <begin position="2051"/>
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            <begin position="2355"/>
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    </feature>
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            <dbReference type="ARBA" id="ARBA00004123"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00007857"/>
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            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Coils"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="7">
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            <dbReference type="Pfam" id="PF11262"/>
        </source>
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            <dbReference type="Pfam" id="PF11732"/>
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    </evidence>
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            <dbReference type="Pfam" id="PF16134"/>
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    </evidence>
    <evidence type="ECO:0000313" key="10">
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            <dbReference type="EMBL" id="CBF86420.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="2429" mass="269433" checksum="4D30C2E6F7BB0AFB" modified="2005-04-26" version="1">MAPGTGGKRKKVDRSWSTDSTNDGQRPSPHRPGNLNMAQQMHSSQSPQSREFSDGRGRLRRQPSRGGRHNAGRAPSNDGQNFTAGRKDADSAGREASEQGKQNGTTPSSSQSQPPQSPLPLASSMQSRPHSQQSSQPQTQPQPAPTPLSHMSPAVPAQPSRKPLPPYQYEYISDDVRDSWAASGRQMIVDRGIQAKNGKDIVMLTSIYQELIRCALDERLPAEEAGLTLRDIIGEEVAAGNIGIDGQEQASPCLDPCTLFLDTLSIVTDSDTTNDALKPLVFSTGINPALMRLQLETPLLQSLGLVRDTFARMGIRKQTNLLYRQSNYNLLREESEGYSKLVTELFTTSNNEPPTAEVVEDTFERVKAMIGAFDMDVGRVLDVTLDVFAAVLVKQYRFFVKLLRASSWWPKEDASTSNGGRSCDSGLPNWALPGSPVWSTTDEERAAAAEANSQRDREFWDRVREVKIRAFFEIGRKPVSEEELKQLLPESNNLTPEEADTRKWIEQTGTLPPKGSRVAAQLLGFKLRFYSSPARDKSDVLPDNLIYLAALLIKVGFISLRDLYPHLWRPDNSMDVLKEEKMKEKAERERAARPGGGVNALMTAGALSDDTLPIPRIRDSEARSATPGKDQEAERTAAAKSEENELPEPSDQKVLLLKSLLAIGAIPESLFILSKFPWLMDAYPELPEFIHRILHHCLSKVYASVRPLPPISELREQKQIPSHDQTGVPKGHIKLTEAPQRRTLRWAQLDKEDTNDGTDYRFYWDDWSDNIPICQSVDDVFALCESFLNISGHKIGQDSSLLTKLARIGRHSLNKDDSTENRARWQDLCKRLLVPAISLTKANPGVVNEVFDLISFFPRDTRYNMYAEWYFGQTSRLPDIQSAFDQARAETKDVLKRLSKTNIRPMARALAKIAYANPGIVINVAISQIESYENLIEVVVECARYFTYLGYDILTWALISSLGQKGRSRVQDGGLLTSRWLNALATFAGRTFKRYSVMDPTPVLQYVVEQLRQNNSTDLIILEQIISSMAGIITDTNFNDSQIQAMAGGEILQSQTILQLLDKRHESKTTSKRLLKSLTSSNLAGQLLIAIAQERLTCIFKESENSSELKLLGNIFDEIHRILAQYLDLLRSNLSVDEFDSFVPDIASLIKDFGIQPEVAFWIRRPSVARKLIDWEKTSQDTANAAKKESQDVPALKAEVEKLEGSGDTEVTDAPSGDDKMDVDQEQTAPDTESIPSRKSATGFGAPEYAASNPVMQDLQDQVKSVLPPETWSIVGLPFYVTFWQLSIYDVHIPQKSYEEEIERLKKKVISIGNDRSDISLAGTQRKEREKKQITQLQDRILEENKAHLVAYGQTRSRLQKEKEGWFVGMRGKADQLHIALLEQCFLPRLLLSPIDAFYCFKMLKFLHAAGAPNFRTVGLLDQLFREQRLTALIFQSTSREADNLGRFLNEVLRDLGRWHADKTVYEKEAFGTKRDLPGFAMNVDPEGKPTTFLDYEDFRRLLYKWHRLLSSALKICLNGGEYMHIRNAISVLKAIVQNFPAVNWIGRDMHTSVNNLSQNDERDDVKIPAASLIGDLNRREKKWMLPQAFMITNQPVPSKGSQATGRATPSRPNSTTPTPFNAAAPEFKPSSATELKGPGKTEGTTRQEVEDGEIEDARTADVPKDSSNAQQPAQKLAETELRQTDKAAGQVSANENRPASGPDTAPRDPPSNPTRSRQTGGATVQSRLSPPPSANQAPRGPESRRPANIPRPPEPDRTPGGSQTTRSQPHTPSHPYRDERGLPPRPDILDDRRDRLSDYGRGGRLPGDRDFSRSFDPPISDSRGFGRLDRDLSFRPPVEEPFRGTQYRDRPGRPRPADSRENLSGQRSGPQTHPDRADLIHDVSDRPGDGYRRGEPLRQEREDRRSLPTRPLTPPKLDLPNRPERFPSDIRKPASNTQPPPRGEEMPRGPRSDRPPRTPMEGPDPRDSVPGSDLPVGRSRQADLMSDIPSGPRSRTAPGRGGRNPPAPHPSAGPPGSGPAVNDRPPPTGPGRQGMRNDDPPADTLSPTAERLEASGIHPDRLKALQGQTSDNAHGSSPRSGLSGPPPIIPPSGPRGGLGAGSGSSPVTRGPPGGPGFGGERGRGDKRFANLNNMLQQSGSPSDRGPGPTSRGRGTNRQPATPRVQSPQATRPQHSGPEEGPRPGVSTESKTDLFAGRPSGYPEGDAHSRSRPGGSGRHEPTDDTNSDGRRSQRYLTGGSFSHDRDREAERERDRRAGDEDGSRSSSRREDGRDRNRERSRRSDVPSGAPRDERYEPREASRRGVGPREDNRRRRDRDAGPESSQEHEGRLRPPSSHGGQPPPPPPPPPPPGGPDEERRWSSSGREPRDRDRDRNRDRNRERNYTRESGSGSGPHRKRGRPGDEGGHSDGSSRGGRGAGSENKRARRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BB98</accession>
    <accession>C8VMH1</accession>
    <name>Q5BB98_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_02182</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
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        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
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                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
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                <person name="Selker E.U."/>
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                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
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                <person name="Asai K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
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        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
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                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
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                <person name="Horio T."/>
                <person name="Horiuchi H."/>
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                <person name="Jones M."/>
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                <person name="Kiel J.A."/>
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                <person name="van der Klei I.J."/>
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                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
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                <person name="Mirabito P."/>
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                <person name="Paszewski A."/>
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                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
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                <person name="van de Vondervoort P.J."/>
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            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
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        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
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                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
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                <person name="Batzoglou S."/>
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                <person name="Basturkmen M."/>
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                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
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                <person name="Butler J."/>
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                <person name="Draht O."/>
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            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
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    <reference evidence="11" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
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                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
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            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
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    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
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        <property type="entry name" value="Znf_CCHC"/>
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    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
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        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
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        <property type="entry name" value="ZF_CCHC"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="9">
        <location>
            <begin position="398"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="501"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="17"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="8">
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            <begin position="79"/>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
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            <begin position="94"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
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            <begin position="109"/>
            <end position="120"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="8">
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
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            <begin position="191"/>
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    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
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            <begin position="206"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="8">
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            <begin position="226"/>
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            <begin position="265"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBF85870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="690" mass="73890" checksum="16798148397B216D" modified="2005-04-26" version="1">MPDIPSDEEDSRNASLAAQRNRGSASASASNPSSRHASREPPSKRRRRGRGKQDVDVQDFVPKGATFSATSLEIDPESESTSASESESSSGSESESESESESESESGSDSEKEIEPEIESRGGGLSAPAPNWNKTGKSVIRTSLHGRQAANANLNGNGKNDAESESAAAKKFEAVNGMYWRSRSSSASPGWKERKTVEEGKSETAVTDDNDVQIEDGEVNGVQEVSADSQSDDSGSLDSEADDSIMLNIGSRGQNRSQHDVIQISDDDSDSEGDGYDPESLSVSQTPATVNILDGSNGDGVDGESIADSESKERALLRFAQKYPTSPSILADLTREDMELQARIMFYNRDINDINLQLPITCMECLQEGHLAEVCPTRECVHCGAWNKHQSSLCPKFRRCQRCRGRGHDAKDCPSALKSSASEIPCDLCGSADHLEYDCDYLWKLPRQDTTSLPVLVSISCAHCTSNRHLIGDCPSLSRPFLSSSFTVRGIDPNLITNINSVVNPRRGGAGALSGRPGRQRGNGLKIRGRADQHAHSPSSDSDDMMSMSLTRGGQGRRAGAGGNRSGNRGSINIRIGGDRSNGGPPPSSARDYRDRDDPYFRGGFNSRQRSMSPGRDRGRPGRSRGRGGQQPPRSPPRGQGRPPGLSNQSRGGRGNGKGGGGRGGRGGGGGDAYRPMPSAAKKAWDRYRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="110" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BCD5</accession>
    <accession>C8VPF4</accession>
    <name>Q5BCD5_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">CDF divalent metal cation transporter (Eurofung)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">ANIA_01795</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF85577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_659399.1">
        <property type="nucleotide sequence ID" value="XM_654307.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BCD5"/>
    <dbReference type="FunCoup" id="Q5BCD5">
        <property type="interactions" value="271"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5BCD5"/>
    <dbReference type="GeneID" id="2875295"/>
    <dbReference type="KEGG" id="ani:ANIA_01795"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN1795"/>
    <dbReference type="eggNOG" id="KOG1483">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013430_4_3_1"/>
    <dbReference type="InParanoid" id="Q5BCD5"/>
    <dbReference type="OMA" id="CLFHQHG"/>
    <dbReference type="OrthoDB" id="9944568at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071577">
        <property type="term" value="P:zinc ion transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1510.10:FF:000021">
        <property type="entry name" value="Solute carrier family 30 (Zinc transporter), member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1510.10:FF:000026">
        <property type="entry name" value="Zinc/cadmium resistance protein-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45820">
        <property type="entry name" value="FI23527P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45820:SF4">
        <property type="entry name" value="ZINC TRANSPORTER 63C, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="Cation efflux protein cytoplasmic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="42"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="303"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="338"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="10">
        <location>
            <begin position="10"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein cytoplasmic" evidence="11">
        <location>
            <begin position="368"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="158"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="224"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="442"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="160"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="188"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="226"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="256"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CBF85577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="500" mass="54514" checksum="1AE422D9FA7A8327" modified="2005-04-26" version="1">MGLSKTNRIMILLVIDTAFFLLELIAGYSVHSLALVADSFHMLNDVISLLVGLWAVKVANRETSSKMYTYGWQRAETLGALVNGVFLVALSLSIFLEAIQRLVEPQEVRNPKLVCGVGCAGLLSNILGLVLFHDHSHGHGHGHGHSHEDAEGVDAAEQGQVHDHGHSHAGRDVAGAITEPTAAYSRRRTIDSQHRSSRRGFEDIGGHPASMRQDIIFAANRNKFPDEDDSYESDERAEDGAGDNGGPTERSTLLGHTDRAANYTDEHAPVRDQTKKDPHETHNHAQPKPKDKKHGHDLNMRGVFLHVMGDALGNIGVILSALVIWLTDYSWRFYVDPGISLVITVIILASAIPLCKAASRILLQAVPHGLSIDHIKEDIESLPGVKGSHHLHVWQLSDTKTVASIHIQVDTEIKGEGSERYMHLAKQVRQCLHAYGIQSSTIQPEFPRDSDTEDNQVGSAHLPSGSPSRTPSIRDGDPQACLLECGDECAGGHCCPTKPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="127" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BCF3</accession>
    <accession>C8VPD5</accession>
    <name>Q5BCF3_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription factor BYE1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ANIA_01777</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Negative regulator of transcription elongation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BYE1 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF85543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_659381.1">
        <property type="nucleotide sequence ID" value="XM_654289.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BCF3"/>
    <dbReference type="SMR" id="Q5BCF3"/>
    <dbReference type="STRING" id="227321.Q5BCF3"/>
    <dbReference type="GeneID" id="2875165"/>
    <dbReference type="KEGG" id="ani:ANIA_01777"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN1777"/>
    <dbReference type="eggNOG" id="KOG1634">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009292_0_0_1"/>
    <dbReference type="InParanoid" id="Q5BCF3"/>
    <dbReference type="OMA" id="AWISCET"/>
    <dbReference type="OrthoDB" id="79252at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd21538">
        <property type="entry name" value="SPOC_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.30:FF:000007">
        <property type="entry name" value="PHD finger domain protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000560">
        <property type="entry name" value="Putative PHD finger domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.30">
        <property type="entry name" value="Transcription elongation factor S-II, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055499">
        <property type="entry name" value="DUF7071"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012921">
        <property type="entry name" value="SPOC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003618">
        <property type="entry name" value="TFIIS_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036575">
        <property type="entry name" value="TFIIS_cen_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11477:SF11">
        <property type="entry name" value="TRANSCRIPTION FACTOR BYE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11477">
        <property type="entry name" value="TRANSCRIPTION FACTOR S-II ZINC FINGER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23257">
        <property type="entry name" value="DUF7071"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07744">
        <property type="entry name" value="SPOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07500">
        <property type="entry name" value="TFIIS_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00510">
        <property type="entry name" value="TFS2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46942">
        <property type="entry name" value="Elongation factor TFIIS domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51321">
        <property type="entry name" value="TFIIS_CENTRAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="9">
        <location>
            <begin position="57"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="TFIIS central" evidence="10">
        <location>
            <begin position="284"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="134"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="410"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="706"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="862"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="134"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="144"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="157"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="258"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="453"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="467"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="727"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="768"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="788"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="879"/>
            <end position="889"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CBF85543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="889" mass="96819" checksum="F64C5E8F8FD7816E" modified="2005-04-26" version="1">MADEPRRSGRSTKGQHKSLDMVNETPTKKTKAKAQPRDKPPKPSAEPTPAPSEEEEIIRCICGEYEEEEDIERDMICCDQCSAWQHNDCMGLTFAKGEVPDQYFCEQCKPEDHPVLMDKIARGEKPWLEVAERRRKEAEELKQARRKKGRRGGKRGRPSEPKEPKPEKSTPSRTPAPRASGTPAAEPPAPVIATPAPEKNSHSPEKPPSSSQKRKLSEQEVSTPESGPKTKQAKISPPAASPAPHVNQSPEDKEPVGQDTNQTPAADTTKTERLKTLEDITNPARRNAASALTKVFVDQISSALAGGSFKMSEGKTGEEVGQQLGISVEEALYQNLMGGGGEATSEAYKIQLRAILFNVKKNPSLRDRLLVGSLTPDALSRMSSQEMASEELQQKDAEIKREAERQHMIIQEQGPRIRRTHKGEELVEDDQTNVSTEPVFSNIPRRVTETDGSPAAQSPTSPSAKQPETDGHKVKTDATPAEPTPHDEHFPTRSHSPGAGQDQVFPEVATHISQPIPTGNVQADAEIDQLLKDDDEPESPPYSPKDHHDEGAVWHGRVVMNPVAEFSSFAKHVAGADLSGRIPWNDLIPSTLLIDGRIKIQSAGEYLCGLRFSQSTDVSVVAISSPDSSKDKSNFDKLFDYFQGRERYGVMGKHPLEAVRDTYLIPIEAGSTKKPEFIELLENNALEDPTPERLFLVVFAVKTGESNPPSVQPPSLHASMEPAASASPLTVTSGTPQQPFATPGPRHLLQYPQTPSPAFPGASHATAPYSQPQPQPQIQHQQPPPKATQYNSSLQPQLPTEPTGLPAAIQVLGGHANTPAIQELLQKAPTITVTQLNVVRDILVRRPQAAADYTTLMDELLGESTTRTNGSGTGSGNGHPPPQQQQPAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BD02</accession>
    <accession>C8VN20</accession>
    <name>Q5BD02_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6604 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_01578</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF85149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_659182.1">
        <property type="nucleotide sequence ID" value="XM_654090.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BD02"/>
    <dbReference type="STRING" id="227321.Q5BD02"/>
    <dbReference type="GeneID" id="2875044"/>
    <dbReference type="KEGG" id="ani:ANIA_01578"/>
    <dbReference type="eggNOG" id="ENOG502QVJW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008976_0_0_1"/>
    <dbReference type="InParanoid" id="Q5BD02"/>
    <dbReference type="OMA" id="YNKNMAD"/>
    <dbReference type="OrthoDB" id="5238236at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046539">
        <property type="entry name" value="DUF6604"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38795">
        <property type="entry name" value="DUF6604 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38795:SF1">
        <property type="entry name" value="DUF6604 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20253">
        <property type="entry name" value="DUF6604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6604" evidence="1">
        <location>
            <begin position="36"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF85149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="881" mass="99942" checksum="21A0E34911A86E7B" modified="2005-04-26" version="1">MFWALTDTKYAGKRRYSTGQAFAKMLPQFLQGSYARYKADTNIFATWLLEAANQCGYQPSSLFASVPTAKKSQQKGKNNASDAEPLHYRATIKDLQKLAEVIASSALTVPEPVLTIAKRAIRLRKVVTSWFLGHGDTTSNERHAHFITVLERICETLEWKSSQSTRPDINHPLPTPEAQSDDANVDGFLNRFAVLTVEEPQDTEEAQATPVGSKKVVKVTVVEDNNEAEDSYFGLLFFKTLCLLRDLENMRRFISITWSEYRDKKIDLMNAAIVTDSALQLARELVEEVEADWHTSLTGKEDNVQNIVYNYAVLTRGSSAAPSREIGLPYNKNMADIAEWCYVPTMVVLESFAKVLQVNHQPVFKKGSFGTYDPKMDRERMSLGQKFNEDQTILFSILPEFCMVNRFGIQMPVQDAVTRGVVEFIKTKKVTLWLCFASQIFLDVHHTMRHSTLGAFEDLRMSGLRIQKTIDDYLQLSKTHPQPRFWPKEGDEEIRNISSTVQSWIIQDRFLDIRVQTKLDRIGPPPEKHALFSQHAILCGLILFHLNTRMQFVGQQLLNQWYDVQQLAFLHNLVIKSPAHKNLRWPDMDAFIKIHGESHIFIGSRPGDAVESLKRLELVTGISSVANFARDSRSRRFHNPNGKHARSLKPTTTVANLFFTKYVEGTEEGAGIVDFDRVLDELSQKSKLGASTEGIQRADPQSIITRKWSNTHNIDTLQLLAFLKAKLFEEEPIILYNYFGMHKRSVELLRLIRDKEHQKFVQYFTSVYLPDESFISNIVILIHHVVQGSAQNARAMGLASGGVEVGSRILISAGDVMREYLKKNGDLACKELRVFCKNKKPIQDDAYDESESDELVHSWLSLEDVLGPKGVASLMTGIQIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="141" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BDK0</accession>
    <accession>C8VRU6</accession>
    <name>Q5BDK0_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">methionine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Methionyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">ANIA_01380</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="19">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>tRNA(Met) + L-methionine + ATP = L-methionyl-tRNA(Met) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13481"/>
            <dbReference type="Rhea" id="RHEA-COMP:9667"/>
            <dbReference type="Rhea" id="RHEA-COMP:9698"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78530"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.10" evidence="3"/>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF87610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_658984.1">
        <property type="nucleotide sequence ID" value="XM_653892.2"/>
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    <dbReference type="AlphaFoldDB" id="Q5BDK0"/>
    <dbReference type="FunCoup" id="Q5BDK0">
        <property type="interactions" value="1034"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5BDK0"/>
    <dbReference type="GeneID" id="2877157"/>
    <dbReference type="KEGG" id="ani:ANIA_01380"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN1380"/>
    <dbReference type="eggNOG" id="KOG1247">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009710_3_2_1"/>
    <dbReference type="InParanoid" id="Q5BDK0"/>
    <dbReference type="OMA" id="HLNTTEY"/>
    <dbReference type="OrthoDB" id="5844513at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017102">
        <property type="term" value="C:methionyl glutamyl tRNA synthetase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004825">
        <property type="term" value="F:methionine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990825">
        <property type="term" value="F:sequence-specific mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006431">
        <property type="term" value="P:methionyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd07957">
        <property type="entry name" value="Anticodon_Ia_Met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00814">
        <property type="entry name" value="MetRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.20:FF:000001">
        <property type="entry name" value="Methionine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.730.10:FF:000031">
        <property type="entry name" value="Putative Methionyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.20">
        <property type="entry name" value="Methionyl-tRNA synthetase, Zn-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041872">
        <property type="entry name" value="Anticodon_Met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023458">
        <property type="entry name" value="Met-tRNA_ligase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014758">
        <property type="entry name" value="Met-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033911">
        <property type="entry name" value="MetRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029038">
        <property type="entry name" value="MetRS_Zn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00398">
        <property type="entry name" value="metG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45765">
        <property type="entry name" value="METHIONINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45765:SF1">
        <property type="entry name" value="METHIONINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19303">
        <property type="entry name" value="Anticodon_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01041">
        <property type="entry name" value="TRNASYNTHMET"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57770">
        <property type="entry name" value="Methionyl-tRNA synthetase (MetRS), Zn-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 14" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 14" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Methionyl/Leucyl tRNA synthetase" evidence="16">
        <location>
            <begin position="16"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl-tRNA synthetase anticodon-binding" evidence="17">
        <location>
            <begin position="432"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="590"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="626"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="637"/>
            <end position="647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU363039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF09334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF19303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CBF87610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="658" mass="73200" checksum="16759C2B9A841AE9" modified="2005-04-26" version="1">MATEQKILPKKGERNILVTSALPYVNNVPHLGNIVGSVLSADVFARYHKACGHPTLYICGTDEYGTATETKALEEKVTPEELCAKYNKIHQEVYEWFEIGFDHFGRTPTQKHTEISQAIFKRLYDNGYLAEKTAEQPYCETHGSFLADRYVEGECPRCHYDDARGDQCDKCGHLLDPFDLINPRCKLDGATPVKRDTKHIHLLLDKLQPEIEKYVLPAMEKGEWPKNSRNITENWLREGLKDRGITRDLKWGVPVPLDGFDNKVLYVWFEACIGYPSITANYTPDWELWWRNPEDVQLYQFLGKDNVPFHSVIFPGCQLGTKEKWTMLHHLNTAEYLNYEGGKFSKSRGIGVFGNNAKETGVAPDVWRYYLLKNRPETGDTQFEWRSFVDSNNSELLAKLGNLVNRVVKLVAASYGSTIPDFTVPESFQPTLDEVTGLLRQYVEEMEGVHLRAGVSTAMKIAEAGNGLIQANRLDNSLIANEPERAAAVVGTVLNLIHLLASVFAPYLPATSKSINEQLNAQFALIPSLEDIKDGWKPVSLKPGHKIGKAQYLFSRIDPKKADIWRDQFGGSQADRQKKEEEAAKAAAKKAAKDAAKAKKKEKKAKEAAAAAAATGAGSVESTAKGGVESTGVTTEGKNDEAVEKVTDGVAQVTFPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BDP9</accession>
    <accession>C8VS49</accession>
    <name>Q5BDP9_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">SUR7/PalI family-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ANIA_01331</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
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                <person name="Cornell M.J."/>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
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                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
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                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
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                <person name="Asai K."/>
                <person name="Machida M."/>
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                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
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    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
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            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
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        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
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        <source>
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    <reference evidence="12" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
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                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
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                <person name="Selker E.U."/>
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                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
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                <person name="Tanaka T."/>
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                <person name="Asai K."/>
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                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
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                <person name="Paoletti M."/>
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                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="12">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
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    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
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                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PRP31 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF87838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_658864.1">
        <property type="nucleotide sequence ID" value="XM_653772.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BDX0"/>
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        <property type="interactions" value="1149"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5BDX0"/>
    <dbReference type="GeneID" id="2877039"/>
    <dbReference type="KEGG" id="ani:ANIA_01260"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN1260"/>
    <dbReference type="eggNOG" id="KOG2574">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026337_2_0_1"/>
    <dbReference type="InParanoid" id="Q5BDX0"/>
    <dbReference type="OMA" id="IGNGPMD"/>
    <dbReference type="OrthoDB" id="4771285at2759"/>
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        <property type="component" value="Chromosome VIII"/>
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    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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        <property type="term" value="C:spliceosomal tri-snRNP complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005687">
        <property type="term" value="C:U4 snRNP"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
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        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000244">
        <property type="term" value="P:spliceosomal tri-snRNP complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="FunFam" id="1.10.246.90:FF:000002">
        <property type="entry name" value="U4/U6 small nuclear ribonucleoprotein Prp31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.4070:FF:000003">
        <property type="entry name" value="U4/U6 small nuclear ribonucleoprotein PRP31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.4070">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Nop_C"/>
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    <dbReference type="InterPro" id="IPR002687">
        <property type="entry name" value="Nop_dom"/>
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    <dbReference type="InterPro" id="IPR036070">
        <property type="entry name" value="Nop_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012976">
        <property type="entry name" value="NOSIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027105">
        <property type="entry name" value="Prp31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019175">
        <property type="entry name" value="Prp31_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13904">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR PRP31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13904:SF0">
        <property type="entry name" value="U4_U6 SMALL NUCLEAR RIBONUCLEOPROTEIN PRP31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01798">
        <property type="entry name" value="Nop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09785">
        <property type="entry name" value="Prp31_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00931">
        <property type="entry name" value="NOSIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89124">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51358">
        <property type="entry name" value="NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Nop" evidence="10">
        <location>
            <begin position="175"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="290"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="462"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="11"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="311"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="474"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CBF87838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="521" mass="55827" checksum="CA0F8A363A8B9132" modified="2005-04-26" version="1">MSNAEELLRDFEDDEDFEGADGVEAIEEDRDEEQLLQEPAKAVTNEFEVALSTADELTRLHKSLRDHYSIRFPELETLVTNSIDYAKTVAILKNGPLTDIKALSTSADNMVGVPLKSILDGPTLMVVAVEGTTTRGREMTEAELKVVMDTCERILKLDRERTALTQSIQANMNQIAPNLAALVGPETAAQFLNQTGGLRELAKIPACNLGAQGSKRKDGLGFATNTSIRSQGFLYNSELIQDIPNDLKRQAIRIVSAKMVLAVRADVSKYSPDGSLGEDLKQQCFQRLEKLTEPPPNSGTKALPAPDDKPSRKRGGRRARKAKEAVAMTELRKAQNRVAFGKEEAEVGYGTGEGTVGLGMLGQQNDGRIRATQIDQRTRAKLSKSNKGWGAATPISGTASSLRTFGQGPSGTASVLQAKGLRSSGIGTSFGGAAGTASTIAFTPVQGLELVDPKVQAELSRKRKAEEDRWFKSGTFTQVGAQNTSKNSSETANGGFKVPALPTKKVDTGAGKMGPPPPPAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="109" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BE21</accession>
    <accession>C8VST2</accession>
    <name>Q5BE21_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Proteasome regulatory particle subunit (Nas6), putative (AFU_orthologue AFUA_1G10700)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ANIA_01209</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF87930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_658813.1">
        <property type="nucleotide sequence ID" value="XM_653721.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BE21"/>
    <dbReference type="FunCoup" id="Q5BE21">
        <property type="interactions" value="170"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5BE21"/>
    <dbReference type="GeneID" id="2876984"/>
    <dbReference type="KEGG" id="ani:ANIA_01209"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN1209"/>
    <dbReference type="eggNOG" id="KOG4412">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000134_18_2_1"/>
    <dbReference type="InParanoid" id="Q5BE21"/>
    <dbReference type="OMA" id="WAVAYNR"/>
    <dbReference type="OrthoDB" id="539213at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904855">
        <property type="term" value="F:proteasome regulatory particle binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070682">
        <property type="term" value="P:proteasome regulatory particle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24173">
        <property type="entry name" value="ANKYRIN REPEAT CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24173:SF74">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="5"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="73"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="109"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="142"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="176"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBF87930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="237" mass="25435" checksum="3FBBDB2BAEA5311C" modified="2005-04-26" version="1">MATTDSKFPLHEAAREGKLSLAESLLNANPKLATTKDDDDRLPIHWAVAYNHLPIVELLVSTKDFDPDVEDGSCWTPLMIAASLRNAEGDPIIELLLRKGADVNAKSITGQNALHFATSKANITTVRTLLENKCSARVKDKRGQLALHRAAAIGSTPIIQLLLKEGRSPVNATDNDGLTALHHAISEGHGDAALTLLKAGAEADKKDASGTLAIDMAPDKKVRNYILQAAEREGIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="105" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BET9</accession>
    <accession>C8VUI1</accession>
    <name>Q5BET9_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Probable alpha/beta-glucosidase agdC</fullName>
            <ecNumber evidence="5">3.2.1.20</ecNumber>
            <ecNumber evidence="6">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">ANIA_00941</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="23" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="23">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Glucosidase involved in the degradation of cellulosic biomass. Has both alpha- and beta-glucosidase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>Hydrolysis of terminal, non-reducing (1-&gt;4)-linked alpha-D-glucose residues with release of alpha-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.20"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 17">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.20" evidence="5"/>
    <dbReference type="EC" id="3.2.1.21" evidence="6"/>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF88483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_658545.1">
        <property type="nucleotide sequence ID" value="XM_653453.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BET9"/>
    <dbReference type="STRING" id="227321.Q5BET9"/>
    <dbReference type="GeneID" id="2876716"/>
    <dbReference type="KEGG" id="ani:ANIA_00941"/>
    <dbReference type="eggNOG" id="KOG1065">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000631_11_0_1"/>
    <dbReference type="InParanoid" id="Q5BET9"/>
    <dbReference type="OMA" id="YKGAVWP"/>
    <dbReference type="OrthoDB" id="5839090at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004558">
        <property type="term" value="F:alpha-1,4-glucosidase activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06602">
        <property type="entry name" value="GH31_MGAM_SI_GAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14752">
        <property type="entry name" value="GH31_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1180:FF:000089">
        <property type="entry name" value="Alpha-glucosidase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1760">
        <property type="entry name" value="glycosyl hydrolase (family 31)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030458">
        <property type="entry name" value="Glyco_hydro_31_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048395">
        <property type="entry name" value="Glyco_hydro_31_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025887">
        <property type="entry name" value="Glyco_hydro_31_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762">
        <property type="entry name" value="ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762:SF67">
        <property type="entry name" value="ALPHA_BETA-GLUCOSIDASE AGDC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13802">
        <property type="entry name" value="Gal_mutarotas_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21365">
        <property type="entry name" value="Glyco_hydro_31_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00129">
        <property type="entry name" value="GLYCOSYL_HYDROL_F31_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="14" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13 17" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="10 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0964">Secreted</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Glycoside hydrolase family 31 N-terminal" evidence="20">
        <location>
            <begin position="108"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 TIM barrel" evidence="19">
        <location>
            <begin position="263"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 31 C-terminal" evidence="21">
        <location>
            <begin position="640"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="417"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="18">
        <location>
            <begin position="422"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00014002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00025512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF01055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF13802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF21365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="CBF88483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="839" mass="94155" checksum="D50AF8C4ECDA4C70" modified="2005-04-26" version="1">MLGFLLFLPLVGAAVIGPRANSQICPGYKASHAKHNSHTFTADLTLAGKPCDTYGTDLKDLKLLVEYQTDERLHVMIYDANEQVYQVPESVLPRVGNGNGTEKDSALKFDYVEEPFSFTVSRNGDVLFDTSASNLIFQSQYLNLRTWLPNDPHLYGLGEHTDSLRLETNNYTRTLWNRDSYGVPSHSNLYGAHPVYYDHRGSAGTHGVFLANSNGMDIKINKTLDGKQYLEYNILGGVLDFYFFTGSTPKEASTQYAKVVGLPAMQSYWTFGFHQCKYGYRDVYEVAEVVYNYSQAGIPLETMWTDIDYMELRRVFTLDPERFPLGKMRELVDYLHDHNQHYIVMVDPAVSTSGAVWPGVTVYPDWFHPAIQDYWNGEFNKFFDPETGIDIDGLWIDMNEAANMCTFPCTDPERYSIENDLPPAPPAVRPSNPRPLPGFPDDFQPGSSKRLSKRAHGDKLGLPGRNLLSPPYSIKNAAGALSQNTIQTNIGHAGGYVEYDTHNLYGTMMSSASRIAMQQRRPDVRPLIITRSTLGDNLSTWKLYRASIAQVLAFASMFQIPMVGADVCGFGSNTTEELCARWASLGAFYTFYRNHNEIGNIPQEYYYWESVTESATKAINIRYQLLDYVYTAFHRQSKTGEPFLQPLFYLYPEDKNTFAIDLQFFYGDAILISPVTEKNSTSVNAYFPKDIFYDWYTGAVIQGQGANIILSNINITHIPIHIRGGNIVPIRSSGAMTTTELRKKGFQLIIASGIDGTASGSLYLDDGDSLEQTDTANIEFEYRSGVLYIKGQFIHDVPVKIESVILLGQTTTAGAGRHNQKQVIETNLELTAPTRVKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BEY2</accession>
    <accession>C8VUS4</accession>
    <name>Q5BEY2_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CENP-V/GFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_00898</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF88566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_658502.1">
        <property type="nucleotide sequence ID" value="XM_653410.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BEY2"/>
    <dbReference type="STRING" id="227321.Q5BEY2"/>
    <dbReference type="GeneID" id="2876667"/>
    <dbReference type="KEGG" id="ani:ANIA_00898"/>
    <dbReference type="eggNOG" id="ENOG502SPQT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098340_0_0_1"/>
    <dbReference type="InParanoid" id="Q5BEY2"/>
    <dbReference type="OMA" id="PWFEEMI"/>
    <dbReference type="OrthoDB" id="3907216at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1590.10">
        <property type="entry name" value="glutathione-dependent formaldehyde- activating enzyme (gfa)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF88566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="255" mass="28650" checksum="13074B73BD505A5C" modified="2005-04-26" version="1">MEHKEPLRGSCMCGRNQYLIRIPDNATDHARVYFDTGRDNRKSYGTPLTAWLRVPLDWYESYTQSFFPDETHGSIRRIFTPHHAPHTQRVFCGFCGSPLTYWSENPREEADFMSVTIGSLYGDDQRILEDLHLLPRWEESESPDISPPAAEQSPTTLVADAPTSQSTVVVPPGVFTEGLSRTVRHGNTNGIPWFEEMIEGSGLGRLMKARYGAGVSGDRSTTIEWEVSDWTITSELGSPSSQSGGKRKLEELHND</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="102" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BFP4</accession>
    <accession>C8VS18</accession>
    <name>Q5BFP4_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phosphatidylinositol N-acetylglucosaminyltransferase GPI3 subunit</fullName>
            <ecNumber evidence="3">2.4.1.198</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">GlcNAc-PI synthesis protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ANIA_00636</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalytic subunit in the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.198" evidence="3"/>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF89087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_658240.1">
        <property type="nucleotide sequence ID" value="XM_653148.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BFP4"/>
    <dbReference type="FunCoup" id="Q5BFP4">
        <property type="interactions" value="455"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5BFP4"/>
    <dbReference type="CAZy" id="GT4">
        <property type="family name" value="Glycosyltransferase Family 4"/>
    </dbReference>
    <dbReference type="GeneID" id="2876413"/>
    <dbReference type="KEGG" id="ani:ANIA_00636"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN0636"/>
    <dbReference type="eggNOG" id="KOG1111">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_19_2_1"/>
    <dbReference type="InParanoid" id="Q5BFP4"/>
    <dbReference type="OMA" id="SHFWMSG"/>
    <dbReference type="OrthoDB" id="734129at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000506">
        <property type="term" value="C:glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017176">
        <property type="term" value="F:phosphatidylinositol N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd03796">
        <property type="entry name" value="GT4_PIG-A-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000053">
        <property type="entry name" value="Phosphatidylinositol N-acetylglucosaminyltransferase GPI3 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000026">
        <property type="entry name" value="Phosphatidylinositol N-acetylglucosaminyltransferase subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039507">
        <property type="entry name" value="PIG-A/GPI3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013234">
        <property type="entry name" value="PIGA_GPI_anchor_biosynthesis"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45871">
        <property type="entry name" value="N-ACETYLGLUCOSAMINYL-PHOSPHATIDYLINOSITOL BIOSYNTHETIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45871:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08288">
        <property type="entry name" value="PIGA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PIGA GPI anchor biosynthesis" evidence="10">
        <location>
            <begin position="42"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="9">
        <location>
            <begin position="218"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00068617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CBF89087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="488" mass="54859" checksum="3EA47CBA158CD916" modified="2005-04-26" version="1">MPYNIAMVSDFFFPQPGGVESHIYQLSTKLIDRGHKVIIITHAYKGRTGVRYLTNGLKVYHVPFLVIYRETTMPTVFSFFPIFRNIVIREQIQIVHGHQSLSSFCHEAILHARTMGLRTAFTDHSLFGFADAGSILTNKLLKFTLSDVDHVICVSHTCKENTVLRASLDPLMVSVIPNAVVAENFRPLHATARANERQSGGGSQIQPPPRPIGPNDIITIVVISRLFYNKGTDLLIAAIPRILASHPNVRFIIAGSGPKAIDLEQMLERNVLQDKVEMLGAIRHEEVRDVMVRGHIYLHPSLTEAFGTVIVEAASCGLYVVCTRVGGIPEVLPQHMTTFAKPEEDDIVLATSKAISALRSNKVRTERFHDQVKVMYSWTDVARRTERVYKGISGDISPQEFYGYYPGEIQEAGDRVRNFALIDRLKRYYGCGVWAGKLFCLCVVIDFLLYTFLEMWFPRANIDIARSWPKKLNGIDGDTAKPEKERSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="111" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BG05</accession>
    <accession>C8VSU9</accession>
    <name>Q5BG05_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ANIA_00525</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF89309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_658129.1">
        <property type="nucleotide sequence ID" value="XM_653037.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BG05"/>
    <dbReference type="GeneID" id="2876303"/>
    <dbReference type="KEGG" id="ani:ANIA_00525"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN0525"/>
    <dbReference type="eggNOG" id="KOG1208">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_9_0_1"/>
    <dbReference type="InParanoid" id="Q5BG05"/>
    <dbReference type="OMA" id="PGFFATD"/>
    <dbReference type="OrthoDB" id="1933717at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0000270"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="CDD" id="cd05324">
        <property type="entry name" value="carb_red_PTCR-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000922">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045313">
        <property type="entry name" value="CBR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051468">
        <property type="entry name" value="Fungal_SecMetab_SDRs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544:SF32">
        <property type="entry name" value="CHAIN DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G01530)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBF89309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="263" mass="28652" checksum="E8D424AF55CB5564" modified="2005-04-26" version="1">MDLTKIVVITGANTGIGFETVKSLLRSNQRYYIFLGGRNLEKAQAASKQLFSESAHHVLEPFQVDVESDESIEAAFKHIASKYNRIDCLINNAGACFDAYIDKDMATRQAWNKSWDVNVTGAHIMTTTFLPLLLNSQDPRLLFITSGLSSLQAASDTTDPKNVIPAAGLPKQLPFVGYRSAKVGLNMLMVEWTKALKKDGVKVWAVAPGLLATSLGGSTELLKKLGAQDPSIGGNTIRRVVEGERDADVGNVVREYGSPIQPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="109" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BGC7</accession>
    <accession>C8VTI3</accession>
    <name>Q5BGC7_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pyridine nucleotide-disulphide oxidoreductase AMID-like, putative (AFU_orthologue AFUA_1G17180)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_00403</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
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    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF89555.1"/>
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    <dbReference type="KEGG" id="ani:ANIA_00403"/>
    <dbReference type="eggNOG" id="KOG2495">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_029131_0_0_1"/>
    <dbReference type="InParanoid" id="Q5BGC7"/>
    <dbReference type="OMA" id="GAAMHQG"/>
    <dbReference type="OrthoDB" id="202203at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
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        <property type="term" value="C:mitochondrial membrane"/>
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    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
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    <dbReference type="PANTHER" id="PTHR43735">
        <property type="entry name" value="APOPTOSIS-INDUCING FACTOR 1"/>
        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR43735:SF24">
        <property type="entry name" value="NUCLEOTIDE-DISULPHIDE OXIDOREDUCTASE AMID-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17180)-RELATED"/>
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        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FADPNR"/>
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    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
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        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
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    <proteinExistence type="predicted"/>
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        <location>
            <begin position="523"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF89555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="534" mass="58266" checksum="F2D2E80F50A2E5DA" modified="2005-04-26" version="1">MLTSRLPVVQYRVRPRHLARYFWKNLLLQPQTRPLSLLQTPRHQTPRTGANLQRCRYVHQSYRNVSTTGQTPESLKSQAPQTPGRGFAVKSLYRFEQAQPFKVLILGGSYAGLAAALNLVDLCHGRRHRFSITEGDNGTGKRIPVQVTIVDPRDGYYHLIGQPLALSSQEFAKSFWIKYTDIPALQTPEIRCVQGSIDSLDCTAKTATIATESGAVQEKYDYLIACTGLRREFPSAPRSLTRETYLAETAENLANIRGAEKGVAVIGGGAVGIEIAAECKMLHPDTPVTLIHSRSSLLSSEPLPAEFASKALEALRGNSVNVILGARVTSITEKDSAQNQTLTLTTNETLTASHVINAVSRYTPTAPSFLPASVCDEHGYIRITPTLEFPSDSVLPASVAGDHYAAGDVARWSGVKRAGAAMHQGHYAARNIHQKLMQRVYGTTPEFVRLDEVEPGMGLAVGKRAVAYFPSMGLSEGEETREMFFQGDLGFMICYKWMQLGTPMPPPVADAPASTPEDKPVNVATTSRTVEAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BGI7</accession>
    <accession>C8VTZ6</accession>
    <name>Q5BGI7_EMENI</name>
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        <recommendedName>
            <fullName evidence="2">Myb-like DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_00343</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF89683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_657947.1">
        <property type="nucleotide sequence ID" value="XM_652855.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BGI7"/>
    <dbReference type="STRING" id="227321.Q5BGI7"/>
    <dbReference type="GeneID" id="2876120"/>
    <dbReference type="KEGG" id="ani:ANIA_00343"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN0343"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_072126_0_0_1"/>
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    <dbReference type="OMA" id="VGFEHQT"/>
    <dbReference type="OrthoDB" id="3944408at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054505">
        <property type="entry name" value="Myb_DNA-bind_8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22980">
        <property type="entry name" value="Myb_DNA-bind_8"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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            <begin position="30"/>
            <end position="75"/>
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        <location>
            <begin position="76"/>
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        <location>
            <begin position="88"/>
            <end position="97"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF22980"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="CBF89683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
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</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="112" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BGW4</accession>
    <accession>C8VUU5</accession>
    <name>Q5BGW4_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ANIA_00216</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF89958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_657820.1">
        <property type="nucleotide sequence ID" value="XM_652728.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BGW4"/>
    <dbReference type="FunCoup" id="Q5BGW4">
        <property type="interactions" value="252"/>
    </dbReference>
    <dbReference type="GeneID" id="2875990"/>
    <dbReference type="KEGG" id="ani:ANIA_00216"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN0216"/>
    <dbReference type="eggNOG" id="KOG1209">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_2_9_1"/>
    <dbReference type="InParanoid" id="Q5BGW4"/>
    <dbReference type="OMA" id="WRGQMAG"/>
    <dbReference type="OrthoDB" id="2102561at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44169">
        <property type="entry name" value="NADPH-DEPENDENT 1-ACYLDIHYDROXYACETONE PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44169:SF6">
        <property type="entry name" value="NADPH-DEPENDENT 1-ACYLDIHYDROXYACETONE PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBF89958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="359" mass="39971" checksum="8D0A7E7F826BFB19" modified="2005-04-26" version="1">MLRKTVLITGCSDNGIGSGLALTFQAQDYYVFATARNPAKMSKLADLPNVTLLPLDVCKNEEITAAVEAVKSHTGGTGKLDYLINNAGQGHFMPILDQDLKNARDLYESNVWGPLAVTQAFAPLLINANGTVTFITSVSGHINCPYIGVYAASKQSLEIIAETLRLELQPFDVRVLSVVTGAVQSMGQVGRFDEYKLPEDSMYKPIEAFIKDRAQGKDGIEREELMTYCNKVVSEITDGRAKKFWCGGSAGFARITSCRKERGLMFWQQIRRAINEYFQTQRLVCGGRFGSGVIVHIHPVFVFIHVRSCIISVHYACSTQAYVRQRNFSLDVGVEHDVHLHTGKALEPEYECMDWMLNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BGW5</accession>
    <accession>C8VUU6</accession>
    <name>Q5BGW5_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">TauD/TfdA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ANIA_00215</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF89959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_657819.1">
        <property type="nucleotide sequence ID" value="XM_652727.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BGW5"/>
    <dbReference type="GeneID" id="2875986"/>
    <dbReference type="KEGG" id="ani:ANIA_00215"/>
    <dbReference type="eggNOG" id="ENOG502QT05">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036005_0_1_1"/>
    <dbReference type="InParanoid" id="Q5BGW5"/>
    <dbReference type="OMA" id="TIIDLWG"/>
    <dbReference type="OrthoDB" id="10257314at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051323">
        <property type="entry name" value="AtsK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468:SF31">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="8">
        <location>
            <begin position="144"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="311"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="318"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBF89959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="352" mass="39557" checksum="2C2CFE6049F91D90" modified="2005-04-26" version="1">MAHLQARQHISPDSGFPVTLHPLFNPGISSHVPPEPIRDEITPPPDRASFADPEKRALFSPGVKRINLTESIGTVLEGVQISQLSASGLKFVNIHGSREDHREILKYTPWPSGDFHADTSFEINRALPATYAPKYLRFADTKGTAPSYSLLRMEEHPEVGGDTAWARKVSQYGLYDALSDAYKKFLDGLHAVHTSRLQYDTILDLWGTGPNRPPIDTHHPAVRTHPVTGLKALNVNPGFVTGFAELKKAESDKVLDFLAYHIHSADDHYVRWKWAVGSVAMWDNRCTLHRVIPGTYEGKRRGIRTTVFGEKPYFDPASESRNERNAREKREKEEKEREKDKGDGVLPVETPV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-22" modified="2026-01-28" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>Q8J0L4</accession>
    <accession>C8V2X8</accession>
    <accession>Q5AXS9</accession>
    <name>MDM10_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mitochondrial distribution and morphology protein 10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Mitochondrial inheritance component mdm10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">mdmB</name>
        <name type="synonym">mdm10</name>
        <name type="ORF">AN6901</name>
    </gene>
    <organism>
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Cell Motil. Cytoskeleton" volume="55" first="114" last="124">
            <title>Deletion of mdmB impairs mitochondrial distribution and morphology in Aspergillus nidulans.</title>
            <authorList>
                <person name="Koch K.V."/>
                <person name="Suelmann R."/>
                <person name="Fischer R."/>
            </authorList>
            <dbReference type="PubMed" id="12740872"/>
            <dbReference type="DOI" id="10.1002/cm.10117"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 3">Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis and may function in phospholipid exchange. mdm10 is involved in the late assembly steps of the general translocase of the mitochondrial outer membrane (TOM complex). Functions in the tom40-specific route of the assembly of outer membrane beta-barrel proteins, including the association of tom40 with the receptor tom22 and small TOM proteins. Can associate with the SAM(core) complex as well as the mdm12-mmm1 complex, both involved in late steps of the major beta-barrel assembly pathway, that is responsible for biogenesis of all outer membrane beta-barrel proteins. May act as a switch that shuttles between both complexes and channels precursor proteins into the tom40-specific pathway. Plays a role in mitochondrial morphology and in the inheritance of mitochondria.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the ER-mitochondria encounter structure (ERMES) or MDM complex, composed of mmm1, mdm10, mdm12 and mdm34. Associates with the mitochondrial outer membrane sorting assembly machinery SAM(core) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <text evidence="1">The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria-endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids.</text>
    </comment>
    <comment type="domain">
        <text>Lacks alpha-helical transmembrane segments, suggesting that it resides in the membrane via beta-sheet conformations similar to those predicted for other outer membrane proteins and porin.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MDM10 family.</text>
    </comment>
    <dbReference type="EMBL" id="AJ536057">
        <property type="protein sequence ID" value="CAD59923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AACD01000113">
        <property type="protein sequence ID" value="EAA58300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF71692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_664505.1">
        <property type="nucleotide sequence ID" value="XM_659413.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8J0L4"/>
    <dbReference type="SMR" id="Q8J0L4"/>
    <dbReference type="FunCoup" id="Q8J0L4">
        <property type="interactions" value="51"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q8J0L4"/>
    <dbReference type="EnsemblFungi" id="CBF71692">
        <property type="protein sequence ID" value="CBF71692"/>
        <property type="gene ID" value="ANIA_06901"/>
    </dbReference>
    <dbReference type="GeneID" id="2870608"/>
    <dbReference type="KEGG" id="ani:ANIA_06901"/>
    <dbReference type="eggNOG" id="ENOG502QUN5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026505_1_0_1"/>
    <dbReference type="InParanoid" id="Q8J0L4"/>
    <dbReference type="OMA" id="VPGYRQI"/>
    <dbReference type="OrthoDB" id="2103793at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032865">
        <property type="term" value="C:ERMES complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001401">
        <property type="term" value="C:SAM complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051654">
        <property type="term" value="P:establishment of mitochondrion localization"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070096">
        <property type="term" value="P:mitochondrial outer membrane translocase complex assembly"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990456">
        <property type="term" value="P:mitochondrion-endoplasmic reticulum membrane tethering"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015914">
        <property type="term" value="P:phospholipid transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045040">
        <property type="term" value="P:protein insertion into mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03102">
        <property type="entry name" value="Mdm10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027539">
        <property type="entry name" value="Mdm10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28035">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28035:SF1">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12519">
        <property type="entry name" value="MDM10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1134">Transmembrane beta strand</keyword>
    <feature type="chain" id="PRO_0000384179" description="Mitochondrial distribution and morphology protein 10">
        <location>
            <begin position="1"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="393"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="393"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="12740872"/>
        </source>
    </evidence>
    <sequence length="427" mass="46345" checksum="8393B663F38E9739" modified="2003-03-01" version="1">MLDFMDYIQLAFAEGTQRNCDNSYSSLTATTQNLLDFTTPERVRIHLSSLSTPNFATSYTLGTVGLIEGSISYLYSNISFDNTPSKSALIPLRKLAPGYRQVQAPIAPPSSKGQKATLLHATLHLPPPTTLNALFLRRISPTMQLSLAVSSTRGPPLSKSAPQATLLTQLTHDTGKYSNEYLFSTDNSLFGWRGLWNFGPDPRFNNNAQRLSLLSAGAEAYYSPVSSLIGMSTGLRFCTLPAATSSTPNPNTPISTFPYTLTLTLTPLTGSLSTSYSVRASPNLSFSSRFGFNVYSWESEMVAGFELWRQSRKAAIVDNDGLEWARNKARIWDIPASSQVPEPITPSEEETQESVLKVRVDQSWNVRLLWEGRVKELLVSAGVGLGPSSFSPSSYANSQATAGAQGSSGGPPTSYWRGVGVSVSYSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>C8V0K2</accession>
    <name>C8V0K2_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cytochrome c mitochondrial import factor (Cyc2), putative (AFU_orthologue AFUA_6G04980)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ANIA_06520</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF70907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467116.1">
        <property type="nucleotide sequence ID" value="XM_050612970.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V0K2"/>
    <dbReference type="STRING" id="227321.C8V0K2"/>
    <dbReference type="GeneID" id="2870210"/>
    <dbReference type="KEGG" id="ani:ANIA_06520"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN6520"/>
    <dbReference type="eggNOG" id="KOG0534">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003827_6_0_1"/>
    <dbReference type="InParanoid" id="C8V0K2"/>
    <dbReference type="OMA" id="GCLRFFI"/>
    <dbReference type="OrthoDB" id="432685at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd06183">
        <property type="entry name" value="cyt_b5_reduct_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001834">
        <property type="entry name" value="CBR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370:SF189">
        <property type="entry name" value="CYTOCHROME C MITOCHONDRIAL IMPORT FACTOR CYC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00406">
        <property type="entry name" value="CYTB5RDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0274">FAD</keyword>
    <keyword evidence="4 8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="10">
        <location>
            <begin position="81"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="22"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601834-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CBF70907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="385" mass="43014" checksum="85F34F14AABBEB68" modified="2009-11-03" version="1">MKPRIRLRGFLLQDAFSARSLARTQRRHATGSSSSPQPPRASPASRRWLRLTLVTVTAAGIGAYIKWMQDMKTASTTLNPGRFTSYQLVSREPVSSTGSLFTIKPPKSDGSNLKVYEDAWNTGVWSVMFKQPQLQIGRDYTPLPPTSANEDDECLRFFIRKDPFGEVSRYLHSLKIGARIEVRGPRIECEIPPDTDRILFIAGGTGIAPALQAGHTLLRRTDHIRKPTIHILWANRQRQDCAGGYNETTDTTAETRMSWLYGLFGSSKSVTRPAPAEVADTVEPSLIVREIEALKAQYPEQVTVQYFVDEESSFIGKKTILECTKTAVPSSPDKSKRNLIFVSGPEGFISYMAGPKLWAQGMELQGPLQGIIKELDLQDWAVWKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>C8V139</accession>
    <name>C8V139_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DEUBAD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ANIA_06603</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF71077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467129.1">
        <property type="nucleotide sequence ID" value="XM_050613177.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V139"/>
    <dbReference type="STRING" id="227321.C8V139"/>
    <dbReference type="GeneID" id="2870514"/>
    <dbReference type="KEGG" id="ani:ANIA_06603"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN6603"/>
    <dbReference type="eggNOG" id="ENOG502S8M1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026585_0_0_1"/>
    <dbReference type="InParanoid" id="C8V139"/>
    <dbReference type="OMA" id="DVWKYSR"/>
    <dbReference type="OrthoDB" id="2289918at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028020">
        <property type="entry name" value="ASX_DEUBAD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044867">
        <property type="entry name" value="DEUBAD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13919">
        <property type="entry name" value="ASXH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51916">
        <property type="entry name" value="DEUBAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DEUBAD" evidence="9">
        <location>
            <begin position="50"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="19"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="238"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="312"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="369"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBF71077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="475" mass="53193" checksum="A0B64C425F870478" modified="2009-11-03" version="1">MRQVIGCYVNLTRTAMKPSVAMASTNSKPKRTPRRAAKDKYEEEILMTSDKSRLIDLDLVKLLALPEAWNCLEESEKQEILDLLPNDTHPNPNRPPDDPNAKIPPLPESFLRYSTNWREAIRHFQLDLQNGHYDPQWMREAEEAVAQRAAGKFDKFKEQEFEEFWGQKQKMDRALAAGESSKIKLSTLIKHGVIRRGDIWKWSRSVRKILIEKEARIIDVNESRLTFAVPAGRRTFLKTPVAPNAKTTGTERRPESPPESSSISPPLTQANGAVSADIKETEAGSSRKRSVEPNTEILPTKRQRGLSPKGPPAQGQGAANAAAVEITNSLSENGMKSSSSSNEHSLDSSAESQESGSNSGAAPQNTKPEVSDDSKLEEPELANSPDEQPSQALPEKDEEPDEVIVRDIQGPTALTLEMLRIDGRVDKATNGNAWKELRCFRDNQDMGTLWEVRHACYLQAIMMHHYLLQRPYFPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>C8V1F0</accession>
    <name>C8V1F0_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ANIA_10843</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF71200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467138.1">
        <property type="nucleotide sequence ID" value="XM_050613343.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V1F0"/>
    <dbReference type="GeneID" id="74896635"/>
    <dbReference type="KEGG" id="ani:ANIA_10843"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN10843"/>
    <dbReference type="eggNOG" id="ENOG502SQRY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1205093_0_0_1"/>
    <dbReference type="InParanoid" id="C8V1F0"/>
    <dbReference type="OMA" id="ARENAWV"/>
    <dbReference type="OrthoDB" id="4487429at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF71200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="242" mass="27896" checksum="C2338192D29646D2" modified="2009-11-03" version="1">MFFSKSYAIINLFLSCQAKEARRKHRCKPRKPEFPIERMVTTINGLWIYGWPSKGGLIVLSHPTRVDFDYLGWDYLNPHRKRDQDQDAEDEVCKMLLRLGATWYDSRSRYNLIAAVAQNVTSARNLFLYDEVPAATAVESLWVRVGWPSTGGLWVAEFIHGAFEDVVDDLVEWDEQDGHYGNAAGQIVLAKDMDERCEILKRLGGRFYASLDDYHGKGCLKMWEHKTTGEVGPLVRTRYVER</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>C8V1N7</accession>
    <name>C8V1N7_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Elongation factor 3 (Eurofung)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">ANIA_06700</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein biosynthesis; polypeptide chain elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ABC transporter superfamily. ABCF family. EF3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF71277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_664304.2">
        <property type="nucleotide sequence ID" value="XM_659212.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V1N7"/>
    <dbReference type="SMR" id="C8V1N7"/>
    <dbReference type="FunCoup" id="C8V1N7">
        <property type="interactions" value="679"/>
    </dbReference>
    <dbReference type="STRING" id="227321.C8V1N7"/>
    <dbReference type="GeneID" id="2870490"/>
    <dbReference type="KEGG" id="ani:ANIA_06700"/>
    <dbReference type="eggNOG" id="KOG0062">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1242">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002848_0_0_1"/>
    <dbReference type="InParanoid" id="C8V1N7"/>
    <dbReference type="OMA" id="VLSEAMW"/>
    <dbReference type="OrthoDB" id="2110130at2759"/>
    <dbReference type="UniPathway" id="UPA00345"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd03221">
        <property type="entry name" value="ABCF_EF-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1390.20:FF:000001">
        <property type="entry name" value="Elongation factor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.990:FF:000001">
        <property type="entry name" value="Elongation factor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000193">
        <property type="entry name" value="Probable Elongation factor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1390.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047038">
        <property type="entry name" value="eEF3_chromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040533">
        <property type="entry name" value="EF3_4HB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047036">
        <property type="entry name" value="EF3_4HB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF5">
        <property type="entry name" value="ELONGATION FACTOR 3A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17947">
        <property type="entry name" value="4HB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24984">
        <property type="entry name" value="HEAT_EF3_GNC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 14" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="300"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="543"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="23"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="851"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="884"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="884"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="895"/>
            <end position="906"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CBF71277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="917" mass="102216" checksum="010A8C3C2648007E" modified="2009-11-03" version="1">MAFRVPDLIPALSANIWDTRDPVKDRIQGTPYKPYQPAKGKKPEQKEQPERTGTLEIVCGLISNKDIEKFIPALVKCIAFPDRVPETIHLLGATTFVSEVTGPTLAIMTPLLERGLKAEQATPIKRKAAVIVDNMCKLVEDPQIVAPFLPLLLPQILKLSGESPDPKENGLADPEARGKCKQALDTLTRVGNVVDGKIPEISTAGDISTVSAILKDILAAKFKSQAEKAEAVINYVAAIAGQLVDEKIAESADWTRNVLPYIAAIVGEADAPAIAETLRKRASPDAAAADAVESDEEEGEDLCNCTFSLAYGAKILLNQTSLRLKRGQRYGLLGPNGSGKTTLMRAINNEQLEGFPKKDEVKTVYVEHDLDSADTEQTVIGWTMKKLREVGLDPVQSEVESKLEEFGFLREQFEGPITALSGGWKMKLALCRAVFEDPDILLLDEPTNHLDVKNVAWLENYLRNSPCTSIIVSHDSKFLDNVLQHVIHYERFKLKRYRGTLSEFVKRVPSARSYYELGASDLEFKFPEPGFLEGVKTKAKAIIRVSNMYFRYPGVDRDQLQDITFQVSLGSRIAVIGPNGAGKSTLVDVLTGEKIATRGEVYHHENIRIAYIKQHAFAHIDNHLDKTPSEYIQWRFQTGEDRETMDRANKQVTEEDEKAELKIYKIEGTPRRVVGVHARRKFKNTYEYECSFLLGENIGMKSEKWTPMSTTDNAWIPRNEIMESHSKKVAEIDAQEALKSGNIRPLIRKEIEDHCAQFGLDAELVSHSQMRGLSGGQRVKVVLAACSWQRPHVIVLDEPTNYLDRDSLGALSKALKAFEGGVIIITHSAEFTQNLTEEVWAVLDGKMTPSGHNWVTGQGSGPRLEEKEGPDEIVDAMGNKIKVEKKVKLSSGDKRKQRKERLARKKRGEDVDDDEDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>C8V1U5</accession>
    <name>C8V1U5_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_06208</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF69959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050466973.1">
        <property type="nucleotide sequence ID" value="XM_050611673.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V1U5"/>
    <dbReference type="GeneID" id="2870805"/>
    <dbReference type="KEGG" id="ani:ANIA_06208"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN6208"/>
    <dbReference type="eggNOG" id="ENOG502SNF8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037139_0_0_1"/>
    <dbReference type="InParanoid" id="C8V1U5"/>
    <dbReference type="OMA" id="YCQTRDS"/>
    <dbReference type="OrthoDB" id="5373426at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF69959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="412" mass="45441" checksum="2F75080D70FE9C24" modified="2009-11-03" version="1">MSRRRASNSESLASSSVNEAVAYPFSGMQQNHTFSQRRGPIEGPGGRRLVRRVTWRSSTYKLMASLWVLGVLYIVWLIRDIFYLPFSYSPKPAVTTNFGDDLLAQFVGREECGISSQALYLPPSGDQSELYCRSREDLLSSMSNGGRHGFGAPYTSQGCFYRWFTNAEICETLSRFDGVLFVGDDSLANAYAGFNILLRQDLKQGSLREWEMSTALQTSCGCESQFTNPACSSARITSSEELYSRSAMGTQTPYICSAKTPHKFLSITGSPATSSDHNVFKNLLARPSESESAKKKPIAIIQSLSLSTSYSLSAAKNSIDEWLTLAKTSARSTPFLWIGPTAPGHQKPPSDNVHATSWKYTQDTAQVAQAKGIDVLAMYNATLQAQSWDGMHYGEEVALMQAMMIVNWLASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>C8V1Y9</accession>
    <name>C8V1Y9_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ANIA_11526</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF71382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V1Y9"/>
    <dbReference type="HOGENOM" id="CLU_3433164_0_0_1"/>
    <dbReference type="InParanoid" id="C8V1Y9"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF71382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="16" mass="1801" checksum="1D035A49015FE7CD" modified="2009-11-03" version="1">MRTRPLLQGRSMIGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2025-10-08" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>C8V2R2</accession>
    <name>C8V2R2_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Zn(II)2Cys6 transcription factor (Eurofung)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ANIA_06884</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF71659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_664488.2">
        <property type="nucleotide sequence ID" value="XM_659396.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V2R2"/>
    <dbReference type="FunCoup" id="C8V2R2">
        <property type="interactions" value="290"/>
    </dbReference>
    <dbReference type="STRING" id="227321.C8V2R2"/>
    <dbReference type="GeneID" id="2870584"/>
    <dbReference type="KEGG" id="ani:ANIA_06884"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN6884"/>
    <dbReference type="eggNOG" id="ENOG502QQTI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007201_2_0_1"/>
    <dbReference type="InParanoid" id="C8V2R2"/>
    <dbReference type="OMA" id="PMLCCTI"/>
    <dbReference type="OrthoDB" id="2262349at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009074">
        <property type="term" value="P:aromatic amino acid family catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052780">
        <property type="entry name" value="AAA_Catabolism_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31644">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR ARO80-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31644:SF4">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="21"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="56"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="60"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="77"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50048"/>
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    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBF71659.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2025-10-08" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>C8V309</accession>
    <name>C8V309_EMENI</name>
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        <recommendedName>
            <fullName evidence="3">PWI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ANIA_06036</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
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        <property type="protein sequence ID" value="CBF70315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_658548.2"/>
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    <dbReference type="VEuPathDB" id="FungiDB:AN6036"/>
    <dbReference type="eggNOG" id="KOG2253">
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        <property type="component" value="Chromosome I"/>
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        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="InterPro" id="IPR034268">
        <property type="entry name" value="RBM25_RRM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18806">
        <property type="entry name" value="RBM25 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18806:SF4">
        <property type="entry name" value="RNA-BINDING PROTEIN 25"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101233">
        <property type="entry name" value="PWI domain"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PWI" evidence="3">
        <location>
            <begin position="669"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="268"/>
            <end position="301"/>
        </location>
    </feature>
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            <begin position="351"/>
            <end position="409"/>
        </location>
    </feature>
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        <location>
            <begin position="426"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="22"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="56"/>
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    </feature>
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            <begin position="92"/>
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            <begin position="284"/>
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    </feature>
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        <location>
            <begin position="369"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
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            <begin position="435"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="447"/>
            <end position="517"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBF70315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="762" mass="84753" checksum="FC8BD610E40B261D" modified="2009-11-03" version="1">MYNPYQPPGMYGRPPDYGVYPGAPPGMAPPPGLAAPGTAPPGLQQANMQQPGRPAGFPPNFQPPPNMPNINFSAPVIRLGTSGPSKSATPDASKERGGDAGRRAGLGASSLESQRQNVRDAMMQLQPPTRDEIVRTIFVGGITEGLGGDEGVERILRSAGNLRRWIRATDADDKPCKFGFAEYEDPESLGTAVEVLKDVQVPVKRQTPSDSEVKEEREVEKSTLLVVVDESSLTYLEQYEASRGSQDPAERQSKLDAAKKALEGVLHDLFHPTSPTQRENASAVDREGDTSMKDAEGQDGTSAEVVTIPITVEDELSDIPPDMRETVAKEIAAFRDRSNRRDIERLKREEEIESLERARNSGGRVNRLASPPASAPSGPAAGANGIPLGGRDRGMPNAPSGPKGFGVQIPKDYQKGVSFVNGGSVNGAPTVYIDHEDENTDADDEELERRRQAKREAELEKQFLDQERRWLNRERSRTAALEREKKRDQEEEDRAQEVRDEADKRLSEWNDDVEASRKSSEYYADRGAWLRSRAAFRAREISMDEADRAAEERERARSIQQREQARGMADDFLARQAEELETRMEAPREPQRFKLSLGAAAQKAQAATSRRTVAEVEGLLEDEEEPQATARRPLIPIKFDSAAEAAGLTEEERAQAARQLAAEIPTDKDGLWKWEIKWEFVDESVVSEQLKPFVEKKIVEYLGVQEQMLVDVVEEHVRKRGNPQELVEQLEEALDEEAEVLVRKLWRMIIFFSESEKRGLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>C8V3A3</accession>
    <name>C8V3A3_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Peroxisomal ATPase PEX1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Peroxin-1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">ANIA_05991</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="16">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF70405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467028.1">
        <property type="nucleotide sequence ID" value="XM_050612271.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V3A3"/>
    <dbReference type="FunCoup" id="C8V3A3">
        <property type="interactions" value="197"/>
    </dbReference>
    <dbReference type="STRING" id="227321.C8V3A3"/>
    <dbReference type="GeneID" id="2870915"/>
    <dbReference type="KEGG" id="ani:ANIA_05991"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN5991"/>
    <dbReference type="eggNOG" id="KOG0735">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000688_1_0_1"/>
    <dbReference type="InParanoid" id="C8V3A3"/>
    <dbReference type="OMA" id="LSASWCA"/>
    <dbReference type="OrthoDB" id="2187at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016558">
        <property type="term" value="P:protein import into peroxisome matrix"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043335">
        <property type="term" value="P:protein unfolding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19526">
        <property type="entry name" value="RecA-like_PEX1_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000149">
        <property type="entry name" value="Nuclear valosin-containing protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.330.10:FF:000011">
        <property type="entry name" value="Peroxisome biogenesis protein peroxin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000458">
        <property type="entry name" value="Peroxisome biogenesis protein peroxin 1 (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001529">
        <property type="entry name" value="Peroxisome biosynthesis protein-like protein (PAS1/Peroxin-1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029067">
        <property type="entry name" value="CDC48_domain_2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015342">
        <property type="entry name" value="PEX1-N_C-lobe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF12">
        <property type="entry name" value="PEROXISOMAL ATPASE PEX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09262">
        <property type="entry name" value="PEX-1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="ADC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54585">
        <property type="entry name" value="Cdc48 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="14">
        <location>
            <begin position="554"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="14">
        <location>
            <begin position="883"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="217"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="323"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="716"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1075"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1134"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1205"/>
            <end position="1225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="331"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="734"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="754"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1075"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1085"/>
            <end position="1095"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CBF70405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="1225" mass="131360" checksum="687598FBEACDFE2F" modified="2009-11-03" version="1">MAPRKPSTTAEVALVSLKNCLVNLPPSLVSLLVNANTPAQNVIVELQFRPTGRTNSGSTTPRSCYLGWTGMPSKRRIAPVVGRDGINNSPSTREQDAATVELDTTFGRFLGLGDGQRVGIFIHLDPPVAHTINIEPLTPEDWEIIELHATFLELNLLSQIRALPNPTYTAAQADHMHPLTLHLSPTSTANIVITSLTPAPPSTSPFAKIAPDAEVIVAPKTRPKANTRVSRGDNRSVTGSSKRSAGGRSSGGSTARGKSSKSETSRGALYFRGLDRQWSDQYFDEESEEDNNEGFRVWLDPDVLASNELRGAEWACVTLVQPSGLKPPSDPQQQMSQAEQKASDSGAPTTKLVAKLLPWIDAPDTQHAGLSSLLCSAIGAEGMVGGIIRVEAAPPPLQRSATRALKVYPFLADATKRNDGLKFGADTIAAKDALVERIKVLYGSTGSGRGLLTGPITDGMVLPKSDNQGTVSAFDGALIRFDPPLKSTSDASKSVFGWLLGSDAKLPLEIQAEIPKPANQSALNLTMEDPIPATAPPMVGIDQVISQALDNLNKSCSVLVTGGLGSGKTALGQLLAHRLQKESLFNVKYFSCRKLVTDETRISNIKETLNRLFMSAAWCARLGGQSTVILDDLDKLCPVETELQVGGDNGRSRQNSEVICSMVREFCSMNSGVVLLATAQSKESLNNVIVGGHVFREVIHLRAPDKEGRRKVLEYLTSQDRRTTSATAEAGPSGATNGHTRTVSTSTNDSWLDPSNPGSRPSSSGGDGFILGRDVDFLDLAGKTDGFMPGDLVLLVARARNEALIRSISEASDESRAIILGAADFDNAIKGFTPASLRNVTLTSSTTTFSAIGGLHETRKMLLETLQYPTKYAPIFAQCPLRLRSGLLLYGYPGCGKTMLASAVAGECGLNFISVKGPEILNKYIGASEKSVRDLFERAQAARPCILFFDEFDSIAPKRGHDSTGVTDRVVNQLLTQMDGAEGLSGVYVLAATSRPDLIDPALLRPGRLDKSLLCDMPNHADRADIIRAVSKKLAMSNEVVARIDEVAARTAGFSGADLQAVVYNAHLEAVHDALGDRSGDKPPAKTAKSSTPSTSSRSFIQFLYSDLEQRAGTVAMPAPAVVASKLDALKNARRRQRQFEQAAGSLAPTTATDNAHETGPAEGREEIVVRWEHMERSLNTTRSSLSEAERRRLLAIYREFVEGRNGEMPNGEGAREVGGRTSLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>C8V3G3</accession>
    <name>C8V3G3_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ANIA_10759</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF70491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467039.1">
        <property type="nucleotide sequence ID" value="XM_050612371.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V3G3"/>
    <dbReference type="GeneID" id="74896588"/>
    <dbReference type="KEGG" id="ani:ANIA_10759"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN10759"/>
    <dbReference type="HOGENOM" id="CLU_1855256_0_0_1"/>
    <dbReference type="InParanoid" id="C8V3G3"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF70491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="138" mass="15601" checksum="65781F9C87960FA8" modified="2009-11-03" version="1">MSTRYRVICSTLRRKPRVRVESRAMTSLAGLLHATDLISATEYRPIGISKSPSGLPFNKLSTSRSGGHNFSLSYLFMYSSVSRLPPQKKSRAFVDNTHTVHGNDWYELLARKHCQSLEVRLLFRATPFVASSTYTFPS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2018-05-23" modified="2025-02-05" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>C8V3Y8</accession>
    <accession>Q5AUZ8</accession>
    <name>ATNC_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MFS efflux pump atnC</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Aspercryptin biosynthesis cluster protein C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">atnC</name>
        <name type="ORF">AN7882</name>
        <name type="ORF">ANIA_11031</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="E99" last="E107">
            <title>Accurate prediction of secondary metabolite gene clusters in filamentous fungi.</title>
            <authorList>
                <person name="Andersen M.R."/>
                <person name="Nielsen J.B."/>
                <person name="Klitgaard A."/>
                <person name="Petersen L.M."/>
                <person name="Zachariasen M."/>
                <person name="Hansen T.J."/>
                <person name="Blicher L.H."/>
                <person name="Gotfredsen C.H."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Mortensen U.H."/>
            </authorList>
            <dbReference type="PubMed" id="23248299"/>
            <dbReference type="DOI" id="10.1073/pnas.1205532110"/>
        </citation>
        <scope>IDENTIFICATION OF THE CLUSTER</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2016" name="ACS Chem. Biol." volume="11" first="2117" last="2123">
            <title>New aspercryptins, lipopeptide natural products, revealed by HDAC inhibition in Aspergillus nidulans.</title>
            <authorList>
                <person name="Henke M.T."/>
                <person name="Soukup A.A."/>
                <person name="Goering A.W."/>
                <person name="McClure R.A."/>
                <person name="Thomson R.J."/>
                <person name="Keller N.P."/>
                <person name="Kelleher N.L."/>
            </authorList>
            <dbReference type="PubMed" id="27310134"/>
            <dbReference type="DOI" id="10.1021/acschembio.6b00398"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2016" name="Angew. Chem. Int. Ed." volume="55" first="1662" last="1665">
            <title>Development of genetic dereplication strains in Aspergillus nidulans results in the discovery of aspercryptin.</title>
            <authorList>
                <person name="Chiang Y.M."/>
                <person name="Ahuja M."/>
                <person name="Oakley C.E."/>
                <person name="Entwistle R."/>
                <person name="Asokan A."/>
                <person name="Zutz C."/>
                <person name="Wang C.C."/>
                <person name="Oakley B.R."/>
            </authorList>
            <dbReference type="PubMed" id="26563584"/>
            <dbReference type="DOI" id="10.1002/anie.201507097"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>PATHWAY</scope>
    </reference>
    <comment type="function">
        <text evidence="2 3 4">MFS efflux pump; part of the gene cluster that mediates the biosynthesis of aspercryptins, linear lipopeptides built from six amino acids including 2 highly unusual and nonproteogenic amino acids, 2-amino-octanoic acid (2aoa) and 2-amino-dodecanol (2adol) (PubMed:23248299, PubMed:26563584, PubMed:27310134).</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="4">Expression is positively regulated by the aspercryptin cluser-specific transcription factor atnN (PubMed:27310134).</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="3">Does not alter the yield of aspercryptin significantly (PubMed:26563584).</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="sequence caution" evidence="6">
        <conflict type="erroneous gene model prediction">
            <sequence resource="EMBL-CDS" id="EAA59536" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF73449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AACD01000135">
        <property type="protein sequence ID" value="EAA59536.1"/>
        <property type="status" value="ALT_SEQ"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V3Y8"/>
    <dbReference type="SMR" id="C8V3Y8"/>
    <dbReference type="STRING" id="227321.C8V3Y8"/>
    <dbReference type="EnsemblFungi" id="CBF73449">
        <property type="protein sequence ID" value="CBF73449"/>
        <property type="gene ID" value="ANIA_11031"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AN11031"/>
    <dbReference type="eggNOG" id="ENOG502QWBF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013756_2_1_1"/>
    <dbReference type="InParanoid" id="C8V3Y8"/>
    <dbReference type="OMA" id="FFYRFCT"/>
    <dbReference type="OrthoDB" id="194139at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd06174">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507:SF1">
        <property type="entry name" value="FI18259P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507">
        <property type="entry name" value="ZGC:174356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000444134" description="MFS efflux pump atnC">
        <location>
            <begin position="1"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="304"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="343"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="377"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="403"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="439"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="469"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="23248299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="26563584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="27310134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="5">
        <source>
            <dbReference type="PubMed" id="26563584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="6"/>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBF73449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="505" mass="54018" checksum="5DE1378E94F61406" modified="2009-11-03" version="1">MRYEELDEACRSLEHLASDAEAEGEDAPLIPDPPGAVSPPTSLSGKAVLQVILLCASATLTLDIGLTVVRAPKIRLFESILCQAYYRTHGNPLPVPMQNIPESQCKTKEIQSGVARLIGWQTVFDGIPAIFLAIPYGALSDSKGRRPVLLLCFLGLALSTAWALLVCWMQWPLELTWISSLFQCLGGGPAVATAVLEATIADVVPDDKRSTIYFQLQATVLISDILANPLSSVLMAHNAWTPCFLGVGIQALATVLLIALPETLDFAKGSRPSDASIYGCKEEEPTLRGCLAKNFRSIVSDRNVAGLVFSLLILTVSAESLDFLLQYVSQRYGWSIAQSAMLLSLRAVVEFGLLLVVGSLLLFTQSSGLRNPRQRDLLIARLSLGLIVAGLLILSLSPTVAPAILVYTLGAGFQPAIMSLLASLWKASNPSNLGSLYSTVAIILAVGGVISGPLISLMYRIGLSLGHGWVGLPYFVASGLCAGIAGVLLSVKLPEQEQKPRRRET</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>C8V459</accession>
    <name>C8V459_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ANIA_10431</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF75766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467515.1">
        <property type="nucleotide sequence ID" value="XM_050611489.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V459"/>
    <dbReference type="STRING" id="227321.C8V459"/>
    <dbReference type="GeneID" id="2873040"/>
    <dbReference type="KEGG" id="ani:ANIA_10431"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN10431"/>
    <dbReference type="eggNOG" id="ENOG502S03T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069181_0_0_1"/>
    <dbReference type="InParanoid" id="C8V459"/>
    <dbReference type="OMA" id="FCGGVWA"/>
    <dbReference type="OrthoDB" id="4436466at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF75766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="238" mass="26212" checksum="8AFFCD713CBB79A0" modified="2009-11-03" version="1">MRIPVPWKVLGSTVGTGGACTILSSFFFTRDIEFVPLESSDPIFHSEHFKRYNPYGNPTIHDLHIKRVPLSQIDPKLRADEDKLLERYCGGVWAGLGFAPQRILLALLCKETDRTDPAAPESVTLWSPSELLESEYKPGTDIAGHFEVIERPKQGHSILIRGGDKISNRGLRPLDGFIELTASVDQQHGLVEFGCKTVFFQGLGPAAGGKLPMPGPVVWLHEQYAKALLASGVSYVCM</sequence>
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<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>C8V4R0</accession>
    <name>C8V4R0_EMENI</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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    </protein>
    <gene>
        <name evidence="1" type="ORF">ANIA_11402</name>
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    <organism evidence="1 2">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF75916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467534.1">
        <property type="nucleotide sequence ID" value="XM_050611511.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V4R0"/>
    <dbReference type="GeneID" id="74896995"/>
    <dbReference type="KEGG" id="ani:ANIA_11402"/>
    <dbReference type="HOGENOM" id="CLU_2333600_0_0_1"/>
    <dbReference type="InParanoid" id="C8V4R0"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF75916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="98" mass="11268" checksum="F2F5F343C47DCF83" modified="2009-11-03" version="1">MSFALAPRNVKTQKQFLSSTKKAMSVQVTNQPFGKCSNHQQEKNLSFLRPVPINRQRSYDRHGGRPANWQLLSKVICFTRFQLLFDRPHPSQALPQSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>C8V7D2</accession>
    <name>C8V7D2_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uroporphyrinogen-III synthase (UroS), putative (AFU_orthologue AFUA_6G12800)</fullName>
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    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_10455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
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        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
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            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF75539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467471.1">
        <property type="nucleotide sequence ID" value="XM_050611442.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V7D2"/>
    <dbReference type="FunCoup" id="C8V7D2">
        <property type="interactions" value="115"/>
    </dbReference>
    <dbReference type="STRING" id="227321.C8V7D2"/>
    <dbReference type="GeneID" id="74896412"/>
    <dbReference type="KEGG" id="ani:ANIA_10455"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN10455"/>
    <dbReference type="eggNOG" id="KOG4132">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051874_0_0_1"/>
    <dbReference type="InParanoid" id="C8V7D2"/>
    <dbReference type="OMA" id="IHGADTG"/>
    <dbReference type="OrthoDB" id="5595751at2759"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00320"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004852">
        <property type="term" value="F:uroporphyrinogen-III synthase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006780">
        <property type="term" value="P:uroporphyrinogen III biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd06578">
        <property type="entry name" value="HemD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10090:FF:000011">
        <property type="entry name" value="Uroporphyrinogen-III synthase (UroS), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10090">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036108">
        <property type="entry name" value="4pyrrol_syn_uPrphyn_synt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003754">
        <property type="entry name" value="4pyrrol_synth_uPrphyn_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039793">
        <property type="entry name" value="UROS/Hem4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12390">
        <property type="entry name" value="UROPORPHYRINOGEN III SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12390:SF0">
        <property type="entry name" value="UROPORPHYRINOGEN-III SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02602">
        <property type="entry name" value="HEM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69618">
        <property type="entry name" value="HemD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tetrapyrrole biosynthesis uroporphyrinogen III synthase" evidence="1">
        <location>
            <begin position="31"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF75539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="310" mass="34423" checksum="F044FB0C26C0CA78" modified="2009-11-03" version="1">MTPLATHPRHILLLKTKSTPHDGYDEFFSAAHTKPTFIPVLSHNFHTQNLSSIKHLFENGSLAPGRDRQYGGLIFTSQRAVEAFGETLSGVEESYLISSSRNLPLYTVGPATARSLTTLRDRYLPHATIHGAETGNGENLAQFMLEHYNALFFQQEGQQAQKKPLLFLVGETRRDIIPKTLMGASVNPERRIGVEEVVVYETGVVEGFEGDFERVLQDCYNDIEDGMIWVVVFSPTGCDAMVRVLRQKEARIAGENGKGARKLFVATIGPTTRDHLVKEYGFEPDVCAAKPSPEGVGAGIEEFMRSLELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>C8V7J6</accession>
    <name>C8V7J6_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ubiquitin C-terminal hydrolase Ubp8, putative (AFU_orthologue AFUA_6G12710)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_03711</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF75558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467475.1">
        <property type="nucleotide sequence ID" value="XM_050611446.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V7J6"/>
    <dbReference type="FunCoup" id="C8V7J6">
        <property type="interactions" value="466"/>
    </dbReference>
    <dbReference type="STRING" id="227321.C8V7J6"/>
    <dbReference type="MEROPS" id="C19.A61"/>
    <dbReference type="GeneID" id="2873134"/>
    <dbReference type="KEGG" id="ani:ANIA_03711"/>
    <dbReference type="eggNOG" id="KOG1867">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008279_11_2_1"/>
    <dbReference type="InParanoid" id="C8V7J6"/>
    <dbReference type="OMA" id="NVSCNCI"/>
    <dbReference type="OrthoDB" id="289038at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031647">
        <property type="term" value="P:regulation of protein stability"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd02660">
        <property type="entry name" value="Peptidase_C19D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000127">
        <property type="entry name" value="Ubiquitin C-terminal hydrolase Ubp8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF937">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="USP" evidence="1">
        <location>
            <begin position="156"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF75558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="484" mass="53848" checksum="CDE7470AD2E82DBD" modified="2009-11-03" version="1">MATVASVSLLSEAEFGCEHLASQLMHDSAASNQFKASFIKTHNALGRRDIFNSNPSSYLKPKYTCLTCSEPCMNGDRKSHTENTGHQFYMESRNRALFCQGCEDLVYDHGLERCRSATPESTLKVARKRRFSESSADELYVKSNANRRPCAKQGVRGLFNLGQTCYLNVILQTLLHDPILSTYFLGNGHQPHDCTVADCIGCAVAEAFADFHSIDKPEGFAALNLLLASWRASPTLAGYQQQDAHEYYQFLVDKLHTSAEGNRENHEKGCSCFFHRTFYGKLRSSVTCDRCGNVTKTEDPIVDLSLDVQVQAKKRAMGGGTGPSATPTLSGCLESFTSPEKLMADVYNCSGCGNTPQKATKQLRIKKLPAILCMQLKKQRFEHTFSVSEKVEGRIDFPLSINMLPYTTNPDSAVDKSRYTYDLSSAVVHKGKLEAGHYYVYCRQGDEWMLFNDDQVTPVTEAEVLGVDAYLLFYNLRCLANAAS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2018-05-23" modified="2025-04-09" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>C8V7P3</accession>
    <name>IVOC_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">N-acetyltryptophan 6-hydroxylase ivoC</fullName>
            <ecNumber evidence="6">1.-.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Benzoate 4-monooxygenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Cytochrome P450 monooxygenase ivoC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Ivory mutation-related protein C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ivoC</name>
        <name evidence="13" type="ORF">ANIA_10573</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="1983" name="Phytochemistry" volume="22" first="1026" last="1028">
            <title>N-acetyl-6-hydroxytryptophan a natural substrate of a monophenol oxidase from Aspergillus nidulans.</title>
            <authorList>
                <person name="McCorkindale N.J."/>
                <person name="Hayes D."/>
                <person name="Johnston G.A."/>
                <person name="Clutterbuck A.J."/>
            </authorList>
            <dbReference type="DOI" id="10.1016/0031-9422(83)85048-1"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="1990" name="J. Gen. Microbiol." volume="136" first="1725" last="1730">
            <title>N-acetyl-6-hydroxytryptophan oxidase, a developmentally controlled phenol oxidase from Aspergillus nidulans.</title>
            <authorList>
                <person name="Birse C.E."/>
                <person name="Clutterbuck A.J."/>
            </authorList>
            <dbReference type="PubMed" id="2126551"/>
            <dbReference type="DOI" id="10.1099/00221287-136-9-1725"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S53" last="S61">
            <title>The CYPome (Cytochrome P450 complement) of Aspergillus nidulans.</title>
            <authorList>
                <person name="Kelly D.E."/>
                <person name="Krasevec N."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
            </authorList>
            <dbReference type="PubMed" id="18824241"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.08.010"/>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2013" name="BMC Microbiol." volume="13" first="91" last="91">
            <title>Comprehensive annotation of secondary metabolite biosynthetic genes and gene clusters of Aspergillus nidulans, A. fumigatus, A. niger and A. oryzae.</title>
            <authorList>
                <person name="Inglis D.O."/>
                <person name="Binkley J."/>
                <person name="Skrzypek M.S."/>
                <person name="Arnaud M.B."/>
                <person name="Cerqueira G.C."/>
                <person name="Shah P."/>
                <person name="Wymore F."/>
                <person name="Wortman J.R."/>
                <person name="Sherlock G."/>
            </authorList>
            <dbReference type="PubMed" id="23617571"/>
            <dbReference type="DOI" id="10.1186/1471-2180-13-91"/>
        </citation>
        <scope>IDENTIFICATION OF THE IVO CLUSTER</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2017" name="Fungal Genet. Biol." volume="101" first="1" last="6">
            <title>Overexpression of a three-gene conidial pigment biosynthetic pathway in Aspergillus nidulans reveals the first NRPS known to acetylate tryptophan.</title>
            <authorList>
                <person name="Sung C.T."/>
                <person name="Chang S.L."/>
                <person name="Entwistle R."/>
                <person name="Ahn G."/>
                <person name="Lin T.S."/>
                <person name="Petrova V."/>
                <person name="Yeh H.H."/>
                <person name="Praseuth M.B."/>
                <person name="Chiang Y.M."/>
                <person name="Oakley B.R."/>
                <person name="Wang C.C.C."/>
            </authorList>
            <dbReference type="PubMed" id="28108400"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2017.01.006"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>PATHWAY</scope>
    </reference>
    <reference key="8">
        <citation type="journal article" date="2019" name="J. Am. Chem. Soc." volume="141" first="16222" last="16226">
            <title>Complete stereoinversion of L-tryptophan by a fungal single-module nonribosomal peptide synthetase.</title>
            <authorList>
                <person name="Hai Y."/>
                <person name="Jenner M."/>
                <person name="Tang Y."/>
            </authorList>
            <dbReference type="PubMed" id="31573806"/>
            <dbReference type="DOI" id="10.1021/jacs.9b08898"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="4 5 6 7 8 12">N-acetyltryptophan 6-hydroxylase; part of the pathway that mediates the biosynthesis of the gray-brown conidiophore pigment (PubMed:23617571, PubMed:28108400). The first step of the pathway is performed by the nonribosomal peptide synthetase ivoA that catalyzes ATP-dependent unidirectional stereoinversion of L-tryptophan to D-tryptophan with complete conversion (PubMed:31573806). While the stereoinversion is catalyzed by the epimerization (E) domain of ivoA, the terminal condensation (C) domain stereoselectively hydrolyzes D-tryptophanyl-S-phosphopantetheine thioester and thus represents a non-canonical C domain function (PubMed:31573806). D-tryptophan is acetylated, probably by an endogenous acetyltransferase (Probable). N-acetyltryptophan is further 6-hydroxylated into N-acetyl-6-hydroxytryptophan (AHT) by the cytochrome P450 monooxygenase ivoC (PubMed:28108400). N-acetyl-6-hydroxytryptophan is substrate of the N-acetyl-6-hydroxytryptophan oxidase ivoB to produce the gray-brown conidiophore pigment (PubMed:2126551, PubMed:28108400, Ref.3).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Pigment biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="6"/>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF77085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V7P3"/>
    <dbReference type="SMR" id="C8V7P3"/>
    <dbReference type="STRING" id="227321.C8V7P3"/>
    <dbReference type="GlyCosmos" id="C8V7P3">
        <property type="glycosylation" value="1 site, No reported glycans"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CBF77085">
        <property type="protein sequence ID" value="CBF77085"/>
        <property type="gene ID" value="ANIA_10573"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AN10573"/>
    <dbReference type="eggNOG" id="KOG0156">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_14_4_1"/>
    <dbReference type="InParanoid" id="C8V7P3"/>
    <dbReference type="OMA" id="QFGWLYT"/>
    <dbReference type="OrthoDB" id="3945418at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11062">
        <property type="entry name" value="CYP58-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000069">
        <property type="entry name" value="Cytochrome P450, putative (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF157">
        <property type="entry name" value="N-ACETYLTRYPTOPHAN 6-HYDROXYLASE IVOC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0349">Heme</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0503">Monooxygenase</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000444122" description="N-acetyltryptophan 6-hydroxylase ivoC">
        <location>
            <begin position="1"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="1">
        <location>
            <position position="453"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P04798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="2126551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="23617571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="6">
        <source>
            <dbReference type="PubMed" id="28108400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="7">
        <source>
            <dbReference type="PubMed" id="31573806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="8">
        <source ref="3"/>
    </evidence>
    <evidence type="ECO:0000303" key="9">
        <source>
            <dbReference type="PubMed" id="18824241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="10">
        <source>
            <dbReference type="PubMed" id="28108400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="11"/>
    <evidence type="ECO:0000305" key="12">
        <source>
            <dbReference type="PubMed" id="31573806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="13">
        <source>
            <dbReference type="EMBL" id="CBF77085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CBF77085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="512" mass="58042" checksum="F0E00EB92B11B4DE" modified="2009-11-03" version="1">MLSLDLVFSFPAWALLLVLTLLYTLYLATTRLLLSPIRHIPGPTLAALSFWPEFYYDVVQRGQYFRQIDKMHQTYGPLVRINPFEIHIQDPSFYPVLYTGPTRRRHKWLWAARMFGNNTSAFATVRHEHHRLRRSALNPLFSKSAIQRLTPHLQHTLARLCSRLDGFAFTRQDVDLGIGLTAFAADVITEYCFGQSLELIGKDNFGKEWIDMVSAPSELGHLVKQCPWILVVCKWAPKALVRALLPGVALLFQIQERMSAQIQPLVDRAAAVDKPADPLTVFDFLLSSTLPQHEKTVDRLKGEGQTLIGAGTLTTGNALKTIIFHVLNDPDIFRKLRAEVDGALENMDILSMSDTAYLERLPYLSACIKEGLRISYGVTHRLQLIAEEPLIYSGVTIPAGTPVGMTSIFMHDNPVVFPQPREFRPERWFEADFETVQAMNRHFVPFSKGSRMCLGMNLAYAEIYLVLAVLFRRYEISLSGVTREDIEMAHDFFDPAPKEGARGLIVQLQKRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>C8V9B4</accession>
    <name>C8V9B4_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cation-transporting ATPase</fullName>
            <ecNumber evidence="13">7.2.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">ANIA_08864</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="19">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Membrane</location>
            <topology evidence="1 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.-" evidence="13"/>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF77849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467765.1">
        <property type="nucleotide sequence ID" value="XM_050611779.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="C8V9B4">
        <property type="interactions" value="340"/>
    </dbReference>
    <dbReference type="STRING" id="227321.C8V9B4"/>
    <dbReference type="GeneID" id="2868397"/>
    <dbReference type="KEGG" id="ani:ANIA_08864"/>
    <dbReference type="eggNOG" id="KOG0208">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001828_3_1_1"/>
    <dbReference type="InParanoid" id="C8V9B4"/>
    <dbReference type="OMA" id="SGWKDPL"/>
    <dbReference type="OrthoDB" id="48943at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990816">
        <property type="term" value="C:vacuole-mitochondrion membrane contact site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903135">
        <property type="term" value="F:cupric ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015662">
        <property type="term" value="F:P-type ion transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:intracellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd07542">
        <property type="entry name" value="P-type_ATPase_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000032">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000057">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000068">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006544">
        <property type="entry name" value="P-type_TPase_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047819">
        <property type="entry name" value="P5A-ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047821">
        <property type="entry name" value="P5B-type_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01657">
        <property type="entry name" value="P-ATPase-V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630:SF8">
        <property type="entry name" value="CATION-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630">
        <property type="entry name" value="CATION-TRANSPORTING ATPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12409">
        <property type="entry name" value="P5-ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01229">
        <property type="entry name" value="COF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="356"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="501"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="540"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="567"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1088"/>
            <end position="1107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1128"/>
            <end position="1147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1175"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1205"/>
            <end position="1222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1242"/>
            <end position="1260"/>
        </location>
    </feature>
    <feature type="domain" description="P5B-type ATPase N-terminal" evidence="17">
        <location>
            <begin position="161"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="16">
        <location>
            <begin position="301"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="15">
        <location>
            <begin position="396"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="66"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="75"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF12409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CBF77849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="1299" mass="146591" checksum="18D2B0B7D9C85C1C" modified="2009-11-03" version="1">MEHSYTASDAQSPVQAAIFMPQRRDSLRSSYSVVTDVGMARSEIFDGPISESIPSSVASFSRRRSRRNSTITFSQHHEQEDAIEWPRGRSMDLEDQVDDTISPDIDDNGSTKFSYRSRQSAYRRSSIEDPLLPRRSLSFGSSNNEWKSKDRIKQEIHIASEDSTLVITGFRTATTGAVLYFFLCTVSLGFAFLIFRWLPRWKIKLLGKYSSLSQCQWAVIEDQWGQLSICEVRDQAYERPLSTIFADSYRYTYDEERNPTVEHLRYLDYRYLRFFYHPLQDKFLLISGWKDPSWTNAKTMRVGLNADERDSREQIFGKNAINIQQKSLFQLLIDEAFHPFYIFQLASLVLWTLDTYYYYAGCIFFISVFSIGTTIIETTSTTRRLKQMSHFECDIRVLRNGFWRSVPSQELVPGDVFEFSDPSLNQVPCDCILLSGDCIVNESMLTGESVPVSKTPLTDDALDHLDLSAPSVHPNVAKHFLFNGTKIIRARRPQRVDDDEAIALAIVMRTGFLTTKGALIRSMLFPKPSGFKFYRDSFRYISVMGIIAVLGFVASFVNFVRLGIRQLSWGLIIVRALDLITIVVPPALPATLTIGTNFALSRLKGKKIFCISPQRVNVGGKLDVICFDKTGTLTEDGLDVLGIRVMTQHQRLSELIPNASPKFITPSTHMACSETYDVIIRIMATCHSLRAVDDELLGDPLDVKMFQFTGWSFQEGRDQTPDHRNLEHETIVPSIARPPNYTHVNCDALDAMNLRRASVIVRQFGDSGATIFVKGAPESVKDICSPESLPSDFEEILSQYTHSGYRVIACAARYERRLSWMRIQKMTRTDAESNLEFIGFIIFENKLKPKSADTISELKQANIRNIMCTGDNILTAISVARECGILGADEPCFIPRFIEGSISCPFALICINSSRSPTVAAPILGPSFDRGEVDLSVPGIACNALNYSLAISGDVFRWVLDYEDEIVAKRMLVRGNVFARMSPDEKHELVEKLQSLDYCCGFCGDGANDCGALKAADVGISLSEAEASVAAPFTSRQFDVSCVPTLIREGRGSLVTSFCCFKYMSLYSAIQFATVSFLYTNASNLGDFQFLFIDLTLILPIAIFMGWTGPCDILSRKRPTADLVSRKVLTPLLGQIVIVVFVQFLAYKSVQSQPWFRAPNIELGEDNIENSENTVLFLTSSFQYILASIVLSVGRPFRKSMRTNVPFLTVIVADLTFSGYMLFRPSTWIKQVMQLTYLSDAFATWLLGLVLGSFLFAWLAERKLFPQLARIIGRLQVLMRPGHQKQRRQYKTLLEDMSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>C8V9F5</accession>
    <name>C8V9F5_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Phosphoketolase, putative (AFU_orthologue AFUA_3G10760)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ANIA_04913</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the XFP family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF76492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467589.1">
        <property type="nucleotide sequence ID" value="XM_050611574.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V9F5"/>
    <dbReference type="STRING" id="227321.C8V9F5"/>
    <dbReference type="GeneID" id="2872714"/>
    <dbReference type="KEGG" id="ani:ANIA_04913"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN4913"/>
    <dbReference type="eggNOG" id="ENOG502QUUF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013954_2_0_1"/>
    <dbReference type="InParanoid" id="C8V9F5"/>
    <dbReference type="OMA" id="GCMDDRE"/>
    <dbReference type="OrthoDB" id="2532903at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016832">
        <property type="term" value="F:aldehyde-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005593">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018969">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019790">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018970">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019789">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase_ThDP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31273">
        <property type="entry name" value="PHOSPHOKETOLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31273:SF1">
        <property type="entry name" value="PHOSPHOKETOLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03894">
        <property type="entry name" value="XFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09363">
        <property type="entry name" value="XFP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09364">
        <property type="entry name" value="XFP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017245">
        <property type="entry name" value="Phosphoketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS60002">
        <property type="entry name" value="PHOSPHOKETOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS60003">
        <property type="entry name" value="PHOSPHOKETOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase N-terminal" evidence="6">
        <location>
            <begin position="54"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase C-terminal" evidence="5">
        <location>
            <begin position="573"/>
            <end position="777"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF09363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF09364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBF76492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="780" mass="87245" checksum="2384B0D60CD611B7" modified="2009-11-03" version="1">MPGEVIERPNPAPKPSHVPDLVEKLIIPAQKTKLEKSDCDALHKYRRAAAYIAAGHWGTCPGLILVYSHLNYLIKKQNLDMLYVVGPGHGAPGLLASLWLEGSLGKFYPQYTKDKEGLHNLISTFSTSAGLPSHINAETPGAIHEGGELGYALSVSFGAVMDNPDLIVTCVVGDGEAETGPTATSWHAIKYIDPAESGAVLPILHVNGFKISERTIFGCMDNREIVCLFTGYGYQVRIVEDLEDIDNDLHSAMSWAVEEIRNIQKAARSGKPIMKPQWPMIVLRTPKGWSGPKELHGQFIEGSFHSHQVPLPNAKKDDEELQALQKWLSSYKPDELFTESGDVIDEILSIIPSDDKKLGMRPEAYKTHLPPDLPDWRQFCVKKGDQFSAMKAIGSFIDQVFVKNPHTVRLFSPDELESNKLSAALSHTGRNFQWDEFSNAKGGRVIEVLSEHLCQGFMQGYTLTGRTGIFPSYESFLGIIHTMMVQYAKFAKMAKETAWHHDVSSINYIETSTWARQEHNGFSHQNPSFIGAVLKLKPYAARVYLPPDANTFLTTLHHCLKSKNYINLMVGSKQPTPVYLSPEEAESHCRAGASIFKFCSTDGGLRPDVVLVGIGVEVMFEVIKAAAILRERCPELRVRVVNVTDLFILENEGAHPHALKHEAFDNLFTEDRSIHFNYHGYVNELQGLLFGRPRLDRATIKGYKEEGSTTTPFDMMLVNEVSRYHVAKAAVTGGARFNEKVKLRHQELCSEFDHNIAETRKYIMNNHQDPEDTYNMPSFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>C8VA30</accession>
    <name>C8VA30_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Magnesium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">ANIA_11107</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="17">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">High-conductance magnesium-selective channel that mediates the influx of magnesium into the mitochondrial matrix. Essential for the splicing of mRNA group II introns in mitochondria by affecting mitochondrial magnesium concentrations, which are critical for group II intron splicing. It also suppresses a variety of mitochondrial intron mutations and its absence may disturb the assembly of mitochondrial membrane complexes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Homopentamer. Forms homooligomers. Interacts with MFM1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Mitochondrion inner membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF78176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_681984.2">
        <property type="nucleotide sequence ID" value="XM_676892.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VA30"/>
    <dbReference type="FunCoup" id="C8VA30">
        <property type="interactions" value="340"/>
    </dbReference>
    <dbReference type="GeneID" id="2868564"/>
    <dbReference type="KEGG" id="ani:ANIA_11107"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN11107"/>
    <dbReference type="eggNOG" id="KOG2662">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025144_2_1_1"/>
    <dbReference type="InParanoid" id="C8VA30"/>
    <dbReference type="OMA" id="HRSNWRA"/>
    <dbReference type="OrthoDB" id="10251508at2759"/>
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        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0045016">
        <property type="term" value="P:mitochondrial magnesium ion transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd12823">
        <property type="entry name" value="Mrs2_Mfm1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.340:FF:000005">
        <property type="entry name" value="Inner membrane magnesium transporter MRS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.128.330:FF:000002">
        <property type="entry name" value="Inner membrane magnesium transporter mrs2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039204">
        <property type="entry name" value="MRS2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13890:SF0">
        <property type="entry name" value="MAGNESIUM TRANSPORTER MRS2 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13890">
        <property type="entry name" value="RNA SPLICING PROTEIN MRS2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22099">
        <property type="entry name" value="MRS2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 14" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 14" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="412"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="442"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="559"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="571"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="583"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
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            <dbReference type="ARBA" id="ARBA00022842"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00046105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00046701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU366042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CBF78176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="594" mass="65670" checksum="D0880206509662ED" modified="2009-11-03" version="1">MLSPSPLKPSVPSASLLRFLRAQSESVLFSTNQPSACRRISTRLPHSSNPLPLEGHSSRTRLELSPCRVRLFSEVEPLRCRMSRCDTLLSQRLSRSPQSRNFSSTRSRPILRRFWDFRRKKQAAEPRRGPSLLDDTENLSLARALAAKASNELRLRCTEFDINGNVTLMNGEFKKSELIAKYGLLPRDLRKIDSSTLPHIFVRPSTILINLLHLRVLIKADRVLVFDAYGSTDSYMQSLFVYDLEGKLRQKQAQSTGAGSLPYEFRALEAVLISVTTGLEEEFNGVREPVVRVLRALEEDIDRDKLRHLLIYSKKLGTFEQKARLVRDAIDDLLEADDDLASMYLTERANGFQREEHDHQEVEMLLESYHKVCDEIVQASGNLVTSIRNTEEVVKAILDANRNSLMLLDLKFSIGTLGLATGTLFSALYGMNLKNFIEESDLGFGAVSVTCFAISALVCVYGLAKLRKLQRVRMWGEAGVGGTPIIPLHSSRASAVPGHRANWRADSIEPVWGSLPGEGRAERMKRLKDSSAAAAARSAASNAASTRAASLRRAIRFPSDSAVKGKENQKDAAAAVGADADTGVQTQSGGSTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>C8VB66</accession>
    <name>C8VB66_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conserved serine-threonine rich protein (AFU_orthologue AFUA_4G04090)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_07038</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF79208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467919.1">
        <property type="nucleotide sequence ID" value="XM_050611951.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VB66"/>
    <dbReference type="GeneID" id="2870120"/>
    <dbReference type="KEGG" id="ani:ANIA_07038"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN7038"/>
    <dbReference type="eggNOG" id="ENOG502SRDH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021527_0_0_1"/>
    <dbReference type="InParanoid" id="C8VB66"/>
    <dbReference type="OMA" id="PKFHILA"/>
    <dbReference type="OrthoDB" id="3946750at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="347"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="461"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="613"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="379"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="390"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="620"/>
            <end position="630"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF79208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="714" mass="79041" checksum="71BAA1073DE674B8" modified="2009-11-03" version="1">MAVAQTRTSIRRLSKASGVNARYLSLSAQIRELWTCSHRYHNSNDLHRKHTRLIFHNHHRSQRPHHPPRSQRIIYPKYQYQSWWSPGWGWGWGGFNSGFLGFQDTPTRYRYGQDDDKGGWEDRAKRRMEWIKKEIEADPYAALFGRRSQPLGLNWGNKLESGLMSLWRSVFGLGEDMSNTNKGKGAKVIDSTLKGQDDSGRTSVDEKVREPMTRDGDMQRRPSTDFRGAGFEFDPISGRMVPVRSEPWGTPEERGKERQGDGQYVENKSIPAGDDLPQEKAEADSNTLSEPNVLDSATKKDSTVPESSERFQGASGPSIVSESQIYASAPTQEASNCLNETVQAAKDEINAETQTHAQVERPVPPQNDNHEAVTPATMPFTQSPYSQKHNTTERSLAEHSVSKAGPDRAGFLSRRENQMPKLVTAESQPYTAVDNRDKDIELLSARDIRAAYEPRRLSIEAEIEAETPKQLDEPSASQTDLKDTHGKSPVNKLGGSVNMPGGPTAPFSGLPDGQALNEDLLQNEPSTATQSSVTETYRIFAYDPSSAKVTEAETISSLQEPSEHLHPTEVLTRLANPAKFSPCLNQMHAEGYEIVSGGGDILVFRKAPAGSSKTIDRLASPSQEPSTESAQLADKDVQGGNFSGQDAPRKQSRKSPQKATVSKVFRRMLVGGLATGGTCYALGVVSEYFRTGGKDGFGIDGFTEFESERRHLER</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C8VBB7</accession>
    <name>C8VBB7_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">DUF907 domain protein (AFU_orthologue AFUA_2G06100)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ANIA_07443</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transient receptor potential (TRP) ion channel family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF79391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467956.1">
        <property type="nucleotide sequence ID" value="XM_050611990.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VBB7"/>
    <dbReference type="STRING" id="227321.C8VBB7"/>
    <dbReference type="GeneID" id="2869546"/>
    <dbReference type="KEGG" id="ani:ANIA_07443"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN7443"/>
    <dbReference type="eggNOG" id="ENOG502QSVZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013753_0_0_1"/>
    <dbReference type="InParanoid" id="C8VBB7"/>
    <dbReference type="OMA" id="KSYWWIF"/>
    <dbReference type="OrthoDB" id="2115177at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010308">
        <property type="entry name" value="TRP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040241">
        <property type="entry name" value="TRP_Flc/Pkd2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032800">
        <property type="entry name" value="TRP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31145:SF5">
        <property type="entry name" value="DUF907 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_2G06100)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31145">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_7G01610)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06011">
        <property type="entry name" value="TRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14558">
        <property type="entry name" value="TRP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01320">
        <property type="entry name" value="TRP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002991519" evidence="9">
        <location>
            <begin position="24"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="339"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="385"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="417"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="479"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="505"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="536"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="567"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="domain" description="ML-like" evidence="10">
        <location>
            <begin position="25"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="660"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="670"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="681"/>
            <end position="694"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CBF79391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="704" mass="76904" checksum="32428FC8A52F38AF" modified="2009-11-03" version="1">MRNFVSAHLTFAALALLPAWGYAADTLSTGSLSTCLTDSDIQVNKLDISFSRSNKTIDFDVSGTNNKEQNVTASLSVTAYGNEVYTKDFDPCDDANYVEQLCPVPAGTFSATGSQTIPDEYVSQIPSIAFSIPDLDGVAKLELKSKDDGKEVACIESELSNGKSTEVPAVSYAAAGMAGAALALSGLSALGSAGHVGSATSSPGFGEVMGWFHTMATTGMLSVNYPKVYSSFAKNFAFSTGLIPLEQMQHSIDNFRKLTGGNLTQNNYDYWKGVSSSSGTNQKRSLNALYGAARLFAREVDASVNSTSSGNDTSSGIDISVDGLSRMSKELLIPQSNTFMTVLLIFAIVIAAITVGILLVKVILELWALNGSFPKKLANFREHYWGLLARTITNLILVVYSIWVMYCVYQFSSGDSWAAQLLAGVTLAIFTGILGFFAYRIVHLARKYKKAGGDASPLYENKEVWRKYSLFYDNYKKGCWWLFIPAILYMLIKGCIIAGANGHGLVQSTGQLVVEALMLGLLLWHRPYVAKSTQWINITIQVVRVLSVVCVLVFVDQLGLSQTTKTVTGVVLIVVQSALTGILAILIAVNAIIICCRENPHARRRKEAEKMNRDIDDLTPLDARDSLLMDHPPRKDYSEMSNFNFTRPYEPFRDTDRLVDSQYHDNPRYGRNVSRGSRGSSDSRDSHGSPDGRHPTKPGYGFAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>C8VBF3</accession>
    <name>C8VBF3_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_07477</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF79456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467961.1">
        <property type="nucleotide sequence ID" value="XM_050611995.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VBF3"/>
    <dbReference type="GeneID" id="2869334"/>
    <dbReference type="KEGG" id="ani:ANIA_07477"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN7477"/>
    <dbReference type="HOGENOM" id="CLU_2277455_0_0_1"/>
    <dbReference type="InParanoid" id="C8VBF3"/>
    <dbReference type="OMA" id="DLPCSKP"/>
    <dbReference type="OrthoDB" id="4497333at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002993094" evidence="1">
        <location>
            <begin position="22"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF79456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="106" mass="11730" checksum="DC72E912E52C3A5E" modified="2009-11-03" version="1">MHIQALSFSIVTFLASIGVRAQVHKDPYHISAFGRPNGIDAGNKVCGGACVTDPNALACKHIEFRPQLGCFECCLSDDDLDHLDFHNKAVPDFDDDTDYDTDEDWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>C8VBS0</accession>
    <name>C8VBS0_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">ANIA_10949</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF79672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467986.1">
        <property type="nucleotide sequence ID" value="XM_050612025.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="C8VBS0">
        <property type="interactions" value="367"/>
    </dbReference>
    <dbReference type="GeneID" id="2869418"/>
    <dbReference type="KEGG" id="ani:ANIA_10949"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN10949"/>
    <dbReference type="eggNOG" id="KOG0065">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_35_0_1"/>
    <dbReference type="InParanoid" id="C8VBS0"/>
    <dbReference type="OMA" id="QRMFQQY"/>
    <dbReference type="OrthoDB" id="245989at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03233">
        <property type="entry name" value="ABCG_PDR_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03232">
        <property type="entry name" value="ABCG_PDR_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000881">
        <property type="entry name" value="ABC multidrug transporter A-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000054">
        <property type="entry name" value="ABC multidrug transporter atrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029481">
        <property type="entry name" value="ABC_trans_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034001">
        <property type="entry name" value="ABCG_PDR_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034003">
        <property type="entry name" value="ABCG_PDR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010929">
        <property type="entry name" value="PDR_CDR_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14510">
        <property type="entry name" value="ABC_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06422">
        <property type="entry name" value="PDR_CDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="532"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="564"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="606"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="642"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="674"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="778"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1195"/>
            <end position="1216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1228"/>
            <end position="1251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1272"/>
            <end position="1298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1318"/>
            <end position="1339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1351"/>
            <end position="1369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1467"/>
            <end position="1488"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="170"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="860"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CBF79672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="1501" mass="169104" checksum="14F75A6D2A178143" modified="2009-11-03" version="1">MSSQPSPPAPSGDVAPPGAVQQPSETVSRITDDNGAPSTAKEKAESSDITCASSEKDIDRDRKDIDQESELKITALARNLSRLSQKSGAVDGTNTFLDSSSDPELDPNSGQFNARKWTKNFLSVANRDPDRYPRRTAGVSFRNLSAFGYGTAADYQMDVANMWLKGFGWIRRKLGFVDRVRIDILRDFEGFVRSGEMLVVLGRPGSGCSTFLKTIAGETHGLWLDDGTDIQYQGISWDEMHSRFRGEVIYQAETEIHFPNLTAGETLLFAAQARTPANRFPGVTRDQYAHHMRDVTMAMLGLSHTMNTLIGNEFIRGVSGGERKRVSIAETILCGCPLQCWDNSTRGLDSSTALEFVRNLRLSTEYTGSTAIVAIYQASQAIYDVFDKAIVLYEGRQIYFGSASDARRFFVEMGFECPDRQTTGDFLTSLTSPTERLVRKGFENLVPRTPDEFAERWKQSAERKRLLEEIEAFQNEHPLGGSKYEEFTRSRAAEKAKGTRAASPYTLSYPMQIRLCLSRGFLRLKGDMSMTLATTIGNSIMALIISSIFYNMNGTTEKFFSRGALLFFAILLNAFSSALEILTLWQQRPIVEKHYKYALYHPSAEAISSMIVDLPAKVLVSIVFNIILYFMTNLRRTAGHFFVFYLFSFTTTLTMSNIFRWIGAISRSMAQAMVPSSIFMLILVIYTGFTIPVRNMHPWFRWLNYLNPIGYAFESLMVNEFSGRRFDCAMYVPDGPGYADVPLSSKICSGRGAVAGQDYIDGDTYLNTSFQYYRSHLWRNYGVLLAFMFFFLAAYIICSELVRAKPSKGEILVFPRGKIPAFAKEVRRDEEDAKTVEKPQLVGEKSDDHVGAISKQTAIFHWQDVCYDIKIKGENRRILDHIDGWVKPGTLTALMGVTGAGKTSLLDVLADRVTMGVITGEMLVDGRLRDDSFQRKTGYVQQQDLHLETSTVREALIFSAMLRQPASIPRKEKLAYVEEVIKMLGMEEYAEAVVGILGEGLNVEQRKRLTIGVELAAKPDLLLFFDEPTSGLDSQTAWSICSLMRKLADHGQAILCTIHQPSAILMQQFDRLLFLAKGGKTIYFGELGENMGTLIEYFEKKGSTPCPKNANPAEWMLEVIGAAPGSHADRDWSEVWNQSPEREQVRAELARMKAELLQKPEPPRTPEYGEFAMPLWSQFLICLKRMFQQYWRSPSYIYSKATMCVIPPIFIGFTFWREPLSLQGMQNQMFAIFMLLVIFPNLVQQMMPYFVTQRALYEVRERPSKAYSWKAFMMASICVELPWNILMAVPAYFCWYYPIGLYRNAGPGETVERGGTMFLLILIFMMFTSTFSSMVIAGIEHPDTGSNIAQLLFSLCLIFNGVLATPQQMPRFWIFMYRVSPFTYLVSSVLSTGLSGAEVECSDIEILKIPPPDGQNCTSYLGPYAEGIHAKLLSDAPNGDCRLCSISSTNQFLASLSINPDDNWRNVGILFVYIVFNAFAAVFLYWLVRVPKKKSQQVKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C8VC88</accession>
    <name>C8VC88_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phenazine biosynthesis-like protein, putative (AFU_orthologue AFUA_4G04380)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ANIA_07010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF79265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467931.1">
        <property type="nucleotide sequence ID" value="XM_050611964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VC88"/>
    <dbReference type="STRING" id="227321.C8VC88"/>
    <dbReference type="GeneID" id="2869991"/>
    <dbReference type="KEGG" id="ani:ANIA_07010"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN7010"/>
    <dbReference type="eggNOG" id="KOG3033">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048756_1_0_1"/>
    <dbReference type="InParanoid" id="C8VC88"/>
    <dbReference type="OMA" id="FIHLHID"/>
    <dbReference type="OrthoDB" id="75169at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.10">
        <property type="entry name" value="Diaminopimelate Epimerase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003719">
        <property type="entry name" value="Phenazine_PhzF-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00654">
        <property type="entry name" value="PhzF_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13774:SF32">
        <property type="entry name" value="ANTISENSE-ENHANCING SEQUENCE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13774">
        <property type="entry name" value="PHENAZINE BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02567">
        <property type="entry name" value="PhzC-PhzF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54506">
        <property type="entry name" value="Diaminopimelate epimerase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF79265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="363" mass="39554" checksum="5CD4B83E52AAE107" modified="2009-11-03" version="1">MAIDLPLEYESSFKLQEQVSDDSSLSQGVPFFGLIQMDFVPQDPSTFKPYLTTMARVDFVTLDVFTTKIYEGNPLAVVFLPAPTSTQLTQRQKQTIAREFNLSETIFVHSESGPSESRKIDIFTGSEELPFAGHPTIGAASWFLHHAPESKPVTRLTMKAGDFPITFQNADLGVVSARVAHNVHIHENQYPLDEILRLYPSVKPYLTQSSIALISIVKGMSQLLVELPSLEALGAVTTANGGEEASSSYLDAGWAEGMVTTYFYVKDVKDELLGRNVIRTRTILGSLEDPATGSAASGLTAYLSLKEGRAGRFVYDIVQGVEMGRRSEIGLEVVTGEKGIESLELRGSAVKVSEGSIVVPQAK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-11-16" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>C8VDI1</accession>
    <accession>Q5AVG2</accession>
    <name>Y1006_EMENI</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein AN11006</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ORF">AN11006</name>
    </gene>
    <organism>
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="sequence caution" evidence="1">
        <conflict type="erroneous gene model prediction">
            <sequence resource="EMBL-CDS" id="EAA61233" version="1"/>
        </conflict>
        <text>The predicted gene AN7718 has been split into 2 genes: AN11004 and AN11006.</text>
    </comment>
    <dbReference type="EMBL" id="AACD01000131">
        <property type="protein sequence ID" value="EAA61233.1"/>
        <property type="status" value="ALT_SEQ"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF79966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VDI1"/>
    <dbReference type="EnsemblFungi" id="CBF79966">
        <property type="protein sequence ID" value="CBF79966"/>
        <property type="gene ID" value="ANIA_11006"/>
    </dbReference>
    <dbReference type="KEGG" id="ani:ANIA_11004"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN11006"/>
    <dbReference type="eggNOG" id="ENOG502RMTN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_356391_0_0_1"/>
    <dbReference type="InParanoid" id="C8VDI1"/>
    <dbReference type="OMA" id="WYLATIF"/>
    <dbReference type="OrthoDB" id="5413827at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038883">
        <property type="entry name" value="AN11006-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056632">
        <property type="entry name" value="DUF7730"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085:SF2">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24864">
        <property type="entry name" value="DUF7730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000413955" description="Uncharacterized protein AN11006">
        <location>
            <begin position="1"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000305" key="1"/>
    <sequence length="255" mass="28959" checksum="E108886C1E15E309" modified="2009-11-03" version="1">MPESPFLLLPPELRLQIYSYVLDIPTPYTTLTQHSKPLIVINDTGNKYTTRAIYRSLHISPNWVGISKSEGPNERSKTLSLLSVNRQIHAEVEHFLYTSHTLFFLNGFDLDHLGEFLDTLSATARSCIRSIGFEVYLFVHNTPGPVKRGFRQYERAARVVREKLPNLRGVVFYFDPWFLACCGDAGFGPWCDERSVLATGVRYLLKVFGGIEPRDKDNDKLRARVEMDLHFLPSSATFKVPGLEQGHAKSLVKVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>C8VDW5</accession>
    <name>C8VDW5_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">ABC transporter (Eurofung)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">ANIA_07839</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF80212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468058.1">
        <property type="nucleotide sequence ID" value="XM_050612104.1"/>
    </dbReference>
    <dbReference type="GeneID" id="2869570"/>
    <dbReference type="KEGG" id="ani:ANIA_07839"/>
    <dbReference type="eggNOG" id="KOG0054">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_27_5_1"/>
    <dbReference type="InParanoid" id="C8VDW5"/>
    <dbReference type="OMA" id="YEYRTIR"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd18579">
        <property type="entry name" value="ABC_6TM_ABCC_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18580">
        <property type="entry name" value="ABC_6TM_ABCC_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000055">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000066">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:005921">
        <property type="entry name" value="ABC transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044746">
        <property type="entry name" value="ABCC_6TM_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044726">
        <property type="entry name" value="ABCC_6TM_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF404">
        <property type="entry name" value="ABC MULTIDRUG TRANSPORTER (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="278"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="314"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="383"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="408"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="497"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="526"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="907"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="949"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1050"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1078"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1153"/>
            <end position="1182"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="282"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="613"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="910"/>
            <end position="1220"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="1257"/>
            <end position="1508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="853"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="860"/>
            <end position="878"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CBF80212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="1511" mass="165543" checksum="18710053A23EBE05" modified="2009-11-03" version="1">MTSSSLPCLAAADAAFGPRVSVACRAFDFTVYFEDLFFACLPAALFLLCCPVSACLQWKEPRRIKRSKLLIWKLISLVALWVCETSFLVVRRLGYPALRNNASLAADMLGVVAIAGAGGLSYIHHCHSIRPSTLLALFLSARSLLTIARVRTLWLIGSSTNEAIVLTLGLGFTICSVVFESLGKEASLVSSTLKPATPEPFSGFWKQASFAWLAGTFHQGYSNVFTVTDLPDLDPQLSGRDVGRKLQEAWAHKEDKSAKHALLRSCLRAYRTPFNSAFIPRLCLSGFTFCQPFLVNATVSWVGNTYAPMDFGRALIGAFAIVYCGMAASNALYGYFTFRFTIRLRGGLISLIHGQTVQTKAAHLGGNTAITLMGTDVERIASGFRLIHEMWASMIEIGVAIYLLERQVGVACIVPALIVVVFVGATVKLSAASSTSQRAWIERVEERLRITSYSLERITEVKMLGLSETISRVIRGLRAAEIAVSAVFRKLLIVRVILSNAPTNLAPMATFVVYAIIALVRDDRSILAATAFTSISLISLVTTPVLTFIQALPAVIQCLGCFDRIQEYCNEVPGPQRADTSDHRPFPGADGDTPIALVQVAGSSKNGGAIQEMEGQSFGWDRSAPAVLRNISLQVPRAAITMIIGPTGSGKSTLIGSILGETVALGCPYEGSRSGVAYCGQETWLRSQTIRQNVLGELPMDRQWYRTVISACGLQKDLAQLPQSDMTPLAGNGTTLSGGQKQRVALARAVYSRHKIVLLDDVFSGIDATTVEHIARHLFGPGGLLRKMHTTVVLATHSRFVLQYADKIVVLADGRIVETDTLQNLKAGNAFVQDMDNALPIPSPLAIQYGKETISPFRDPDDDDDDDDDDDDSDEAESCSEQQSQSLSRQQGDLSIYAYYASASGKITVALCLGCALIWAICGELTTVWLDIWTSANAEHPNSRLGMYLGVYVFLGIASIFFAIAVSWYDYACLMQLFRRTNSPMTLCRLLMVNIVSSSALKLHERVLTSTFRAPIHFFHQVDIGSITNRFSQDMDLIDMSLPIEVFNVLACKLTFMLMLGGCTCLVKLVILCVFAKYLSVAVPFAGAVVYFTQRFYLRTSRQLRFLDIEAKAPLYTHFLELVKGAATVRAFGWQRSFDEACLSLLDASQRPVYLLLCVQQCLGFFLDMLVSILAIILITTVVFLREKFDPGDVGVALVMVMTFNNTLMQLVKDWTNMETSIGAVSRVKGYTSTTDPEENTANVPSLPGDWPAVGRVELSAVVASHPSRSELVLKEVSISIKAGEKVAICRPSGSGKTSLILALLGMVEVQEGTISIDGINILEHSRAQVRRKLNVVTQDPFLIAGSVRFNIDPLQTASDQKIISALQILGLWDRIAQEGGLDGRMEPDAWSQGQRQLLCLARAMVQQGKLLILDEAMSRYAMLYAITNADNAYPAFFPSVDNETEDIMQAAINSEFSSHTVLAVMHRLRHIYCYDRVVLLVDGVVVEFDSPTALLTKQSRFKELYESGKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>C8VEL8</accession>
    <name>C8VEL8_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_08503</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF80684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468107.1">
        <property type="nucleotide sequence ID" value="XM_050612159.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VEL8"/>
    <dbReference type="GeneID" id="2868852"/>
    <dbReference type="KEGG" id="ani:ANIA_08503"/>
    <dbReference type="HOGENOM" id="CLU_2108992_0_0_1"/>
    <dbReference type="InParanoid" id="C8VEL8"/>
    <dbReference type="OMA" id="PTMSINA"/>
    <dbReference type="OrthoDB" id="5532350at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF80684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="115" mass="12738" checksum="C4CDC18EF78172BC" modified="2009-11-03" version="1">MALNATRPTLQRSVSSSSALQQHHRPFSIAVPARYATQTSNHTLSQSQPQTPRGFLAEKGPFKFQQRAISYEEVVSRSRSNENAAENIPAASELATLRKRTEEQKKTIGVLQGTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>C8VGX1</accession>
    <name>C8VGX1_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">NADH dehydrogenase (Eurofung)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ANIA_10660</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NADH dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF82129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468287.1">
        <property type="nucleotide sequence ID" value="XM_050612355.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VGX1"/>
    <dbReference type="STRING" id="227321.C8VGX1"/>
    <dbReference type="GeneID" id="74896531"/>
    <dbReference type="KEGG" id="ani:ANIA_10660"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN10660"/>
    <dbReference type="eggNOG" id="KOG2495">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021377_1_2_1"/>
    <dbReference type="InParanoid" id="C8VGX1"/>
    <dbReference type="OMA" id="DHCIFLD"/>
    <dbReference type="OrthoDB" id="3244603at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045024">
        <property type="entry name" value="NDH-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054585">
        <property type="entry name" value="NDH2-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706">
        <property type="entry name" value="NADH DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706:SF17">
        <property type="entry name" value="NADH DEHYDROGENASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22366">
        <property type="entry name" value="NDH2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
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    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="37"/>
            <end position="335"/>
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    </feature>
    <feature type="domain" description="External alternative NADH-ubiquinone oxidoreductase-like C-terminal" evidence="7">
        <location>
            <begin position="446"/>
            <end position="512"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00005272"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF22366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBF82129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="516" mass="57945" checksum="A72609E0656F32F1" modified="2009-11-03" version="1">MMKLLFRTLPQLPRQRWHSVRTLSTDVLEKPRDDKERVVILGSGWGGYTMSRKLSPKRFAPVVVSPRSYFVFTPLLTDTAGGDLDFSHIVEPVRDPKIRVDFIQAAARAIDLHRKTVLCEPTIVKSGVTLTHTEEDEKSETFEIPYDKLVISVGAISRTFKTPGVKDNAIFFKDIGDSRRVRRRVRECFELATLPSTSPEMRKHLLHFAIVGAGPTGTELAAALRDFITSDLITLYPTLEGLPRISLYDVAPKVLSMFDESLSRYAQETMKKEGIEVQTSHHIQDLRWGAPGAEPPYQKDPRGCLTLTTKEEGQIGVGMCVWVTGNSMNELLRDSLRDVEVFPFNSAVMKDGTEVSKDASQGSWAYKKAPRSGALLVDGHLRVQLENDTGATAVLQDVFAIGDNAMLEGASPPATAQVTAQEAKWLATHLNQRDLQSSPPFSFRNMGTLAYIGNEKALMQLPNEERGYLPQKLTGRTAWLVWNSAYLTMTISWRNKLRVAFRWMLNRLFGRDISRY</sequence>
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    <accession>C8VHT4</accession>
    <name>C8VHT4_EMENI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_11353</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
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    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF84361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468583.1">
        <property type="nucleotide sequence ID" value="XM_050612692.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VHT4"/>
    <dbReference type="GeneID" id="74896953"/>
    <dbReference type="KEGG" id="ani:ANIA_11353"/>
    <dbReference type="HOGENOM" id="CLU_3159981_0_0_1"/>
    <dbReference type="InParanoid" id="C8VHT4"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF84361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="48" mass="5901" checksum="BEDE6BEF368FAB0B" modified="2009-11-03" version="1">MQSQRGDTTIISNRSRTRSRHQQLPQQQQQQQQQQQQQQQQQQQQQQQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2019-02-13" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>C8VI81</accession>
    <accession>Q5B8A5</accession>
    <name>PKFB_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cytochrome P450 monooxygenase pkfB</fullName>
            <ecNumber evidence="5">1.-.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Aspernidine A biosynthesis cluster protein pkfB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">pkfkB</name>
        <name type="ORF">ANIA_03225</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2012" name="J. Am. Chem. Soc." volume="134" first="8212" last="8221">
            <title>Illuminating the diversity of aromatic polyketide synthases in Aspergillus nidulans.</title>
            <authorList>
                <person name="Ahuja M."/>
                <person name="Chiang Y.M."/>
                <person name="Chang S.L."/>
                <person name="Praseuth M.B."/>
                <person name="Entwistle R."/>
                <person name="Sanchez J.F."/>
                <person name="Lo H.C."/>
                <person name="Yeh H.H."/>
                <person name="Oakley B.R."/>
                <person name="Wang C.C."/>
            </authorList>
            <dbReference type="PubMed" id="22510154"/>
            <dbReference type="DOI" id="10.1021/ja3016395"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2013" name="Org. Lett." volume="15" first="2862" last="2865">
            <title>Molecular genetic characterization of the biosynthesis cluster of a prenylated isoindolinone alkaloid aspernidine A in Aspergillus nidulans.</title>
            <authorList>
                <person name="Yaegashi J."/>
                <person name="Praseuth M.B."/>
                <person name="Tyan S.W."/>
                <person name="Sanchez J.F."/>
                <person name="Entwistle R."/>
                <person name="Chiang Y.M."/>
                <person name="Oakley B.R."/>
                <person name="Wang C.C."/>
            </authorList>
            <dbReference type="PubMed" id="23706169"/>
            <dbReference type="DOI" id="10.1021/ol401187b"/>
        </citation>
        <scope>IDENTIFICATION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>PATHWAY</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2015" name="Genetics" volume="199" first="1127" last="1142">
            <title>Beyond asexual development: modifications in the gene expression profile caused by the absence of the Aspergillus nidulans transcription factor FlbB.</title>
            <authorList>
                <person name="Oiartzabal-Arano E."/>
                <person name="Garzia A."/>
                <person name="Gorostidi A."/>
                <person name="Ugalde U."/>
                <person name="Espeso E.A."/>
                <person name="Etxebeste O."/>
            </authorList>
            <dbReference type="PubMed" id="25701285"/>
            <dbReference type="DOI" id="10.1534/genetics.115.174342"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="4 5 8">Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of aspernidine A, a prenylated isoindolinone (PubMed:23706169). The starting point of the biosynthesis of aspernidin A is the production of orsellinaldehyde by the non-reducing polyketide synthase pkfA (PubMed:22510154). Hydroxylation, methylation of one of the phenol groups, and prenylation, presumably catalyzed by the prenyltransferase pkfE, would be needed to yield aspernidine D (Probable). Subsequently, the cytochrome P450 monooxygenase pkfB is responsible for hydroxylation of aspernidine D to yield aspernidine E (PubMed:23706169). The dehydrogenase pkfF may be responsible for further oxidation of aspernidine E to form a dialdehyde intermediate which is further transformed in a series of steps, some of which are enzyme-mediated, to generate aspernidine A (Probable). The possibility that additional enzymes outside of the cluster are involved in aspernidine A biosynthesis cannot be excluded.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="5">Abolishes the production of aspernidine A, but accumulates the intermediate aspernidine D.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="sequence caution" evidence="7">
        <conflict type="erroneous gene model prediction">
            <sequence resource="EMBL-CDS" id="EAA63126" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="5"/>
    <dbReference type="EMBL" id="AACD01000054">
        <property type="protein sequence ID" value="EAA63126.1"/>
        <property type="status" value="ALT_SEQ"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF83149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VI81"/>
    <dbReference type="SMR" id="C8VI81"/>
    <dbReference type="STRING" id="227321.C8VI81"/>
    <dbReference type="GlyCosmos" id="C8VI81">
        <property type="glycosylation" value="2 sites, No reported glycans"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CBF83149">
        <property type="protein sequence ID" value="CBF83149"/>
        <property type="gene ID" value="ANIA_03225"/>
    </dbReference>
    <dbReference type="GeneID" id="2874149"/>
    <dbReference type="KEGG" id="ani:ANIA_03225"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN3225"/>
    <dbReference type="eggNOG" id="KOG0159">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_14_0_1"/>
    <dbReference type="InParanoid" id="C8VI81"/>
    <dbReference type="OMA" id="PWVINRH"/>
    <dbReference type="OrthoDB" id="3934656at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="CDD" id="cd11060">
        <property type="entry name" value="CYP57A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000050">
        <property type="entry name" value="Cytochrome P450 monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF175">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE PKFB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0349">Heme</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0503">Monooxygenase</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000446360" description="Cytochrome P450 monooxygenase pkfB">
        <location>
            <begin position="1"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="1">
        <location>
            <position position="450"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P04798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="22510154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="23706169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="6">
        <source>
            <dbReference type="PubMed" id="23706169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="7"/>
    <evidence type="ECO:0000305" key="8">
        <source>
            <dbReference type="PubMed" id="23706169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBF83149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="508" mass="57688" checksum="A5EB641DD6E9CED6" modified="2009-11-03" version="1">MDHPHPSTFSLGLSQILVCLALLYAAIHILSVYRRLCHISGPFWARISNLPRVWWVNTSRAHEIHQQLHEKYGDVVRFGPNMVSLRNPTWIPTVYPTRMGVKKSDFYRTLAPYTPSGALPAVFSSRDEEVHRGLRGPIASLYSMSKVLPLEVFVDRTIDVLVRQLDGRFAGAGETFDLASWLQFFAFDVMGTLTFSKRYGFLEKGMDVHGMLDTIWRFLKGAAPFTQIPWVDEIWNKNVLATKLKGATGVSILGIVGKFVSQRQEESKAGKIDGTADRDMLSLFMEIQKNNQLPPWYVTAWTFSNITAGSDSAAVVMRTVFYNLLSHPSTLQKLRSELLSAGPLTQPYPSWKDVCNLPYLDACILEALRLHPPFCLPFERIVPQGGMVLGDTYFPEGTVVGMSPWVVNRHKPTFGEDSDVWNPERWMVSKELKSKREAAVLTFGAGRRVCLGRHIAILELKKIVPALVLRYDFELIDPERFTTENFWFFRQRGMDVRVKKRMQAEAGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2025-10-08" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>C8VJD9</accession>
    <name>C8VJD9_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glutathione peroxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ANIA_02846</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a hydroperoxide + [thioredoxin]-dithiol = an alcohol + [thioredoxin]-disulfide + H2O</text>
            <dbReference type="Rhea" id="RHEA:62620"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.11.1.24"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the glutathione peroxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF83884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_660450.2">
        <property type="nucleotide sequence ID" value="XM_655358.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VJD9"/>
    <dbReference type="FunCoup" id="C8VJD9">
        <property type="interactions" value="572"/>
    </dbReference>
    <dbReference type="STRING" id="227321.C8VJD9"/>
    <dbReference type="GeneID" id="2874007"/>
    <dbReference type="KEGG" id="ani:ANIA_02846"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN2846"/>
    <dbReference type="eggNOG" id="KOG1651">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029507_3_0_1"/>
    <dbReference type="InParanoid" id="C8VJD9"/>
    <dbReference type="OMA" id="TFPMTEK"/>
    <dbReference type="OrthoDB" id="446890at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140824">
        <property type="term" value="F:thioredoxin-dependent peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097308">
        <property type="term" value="P:cellular response to farnesol"/>
        <property type="evidence" value="ECO:0000270"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0000270"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="CDD" id="cd00340">
        <property type="entry name" value="GSH_Peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000010">
        <property type="entry name" value="Glutathione peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000889">
        <property type="entry name" value="Glutathione_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029759">
        <property type="entry name" value="GPX_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029760">
        <property type="entry name" value="GPX_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592">
        <property type="entry name" value="GLUTATHIONE PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592:SF78">
        <property type="entry name" value="GLUTATHIONE PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00255">
        <property type="entry name" value="GSHPx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01011">
        <property type="entry name" value="GLUTPROXDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00460">
        <property type="entry name" value="GLUTATHIONE_PEROXID_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00763">
        <property type="entry name" value="GLUTATHIONE_PEROXID_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51355">
        <property type="entry name" value="GLUTATHIONE_PEROXID_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 7 9" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="5" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="261"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBF83884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="282" mass="31186" checksum="E64876001032A0D1" modified="2009-11-03" version="1">MPFTYCGLVPRLLSFRSSSSSTRQVRLRIPIQKTTASPGRISGATISSSFASRTSACILHFPSHRTLLQRQQPHLRPSQSTARYRFSTMASATTFYDFEPVDKKGEAYPLNQLKGKVILVVNTASKCGFTPQFKGLETLYQSIKAKRPDDFVILGFPCNQFGGQDPGSNDQIQEFCQLNYGVTFPVLGKTEVNGDNANPLWTWLKESQPGLLGLKRIKWNFEKFLISADGKVVGRWASTTKPEGLESRILEEIEKAEKQGLLASKAMQPEAAGTDGETAKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>C8VJI8</accession>
    <name>C8VJI8_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_02809</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF83972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_660413.2">
        <property type="nucleotide sequence ID" value="XM_655321.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VJI8"/>
    <dbReference type="GeneID" id="2874427"/>
    <dbReference type="KEGG" id="ani:ANIA_02809"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN2809"/>
    <dbReference type="eggNOG" id="ENOG502S6JE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033726_0_0_1"/>
    <dbReference type="InParanoid" id="C8VJI8"/>
    <dbReference type="OMA" id="GSPQIEH"/>
    <dbReference type="OrthoDB" id="2245989at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021833">
        <property type="entry name" value="DUF3425"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38116:SF1">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38116">
        <property type="entry name" value="CHROMOSOME 7, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11905">
        <property type="entry name" value="DUF3425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF83972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="299" mass="34495" checksum="EF946E55EDDE807C" modified="2009-11-03" version="1">MAEMNTPSSLQRDRPIIPLTHMPQQANVWKADDDWTGVVDRGERRKLQNRQNQRKWRQRKKASARGFRTSTSPLSSVASISYEDPTETAKQEYEDGSDVFCGHAPPNALQYLRSFEATLRQSYLTNSPQLDHLIGLTRLNVHKAIRENIRAIGMTIEWTICEDSISIFNLAPPSPNLNIDRIPVSLRPTEIQKSLPHHPWLDFFPFPAMRDTLISAAHLFDDEELCHDLMAFWDTRNTQATLVVWGVSWEPGNWEVTEGFARKWGWLLKGSPELLVSTNIWRMKRGERPLDWRRILAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>C8VK94</accession>
    <name>C8VK94_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nuclear pore complex protein Nup85</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ANIA_09109</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Functions as a component of the nuclear pore complex (NPC).</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the nuclear pore complex (NPC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
            <location evidence="1 9">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the nucleoporin Nup85 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF82532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468347.1">
        <property type="nucleotide sequence ID" value="XM_050612423.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VK94"/>
    <dbReference type="STRING" id="227321.C8VK94"/>
    <dbReference type="GeneID" id="2868045"/>
    <dbReference type="KEGG" id="ani:ANIA_09109"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN9109"/>
    <dbReference type="eggNOG" id="ENOG502SIA5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002336_0_0_1"/>
    <dbReference type="InParanoid" id="C8VK94"/>
    <dbReference type="OMA" id="YKPSPAC"/>
    <dbReference type="OrthoDB" id="5422384at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011502">
        <property type="entry name" value="Nucleoporin_Nup85"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13373">
        <property type="entry name" value="FROUNT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13373:SF21">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07575">
        <property type="entry name" value="Nucleopor_Nup85"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 9" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="7 9" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0811">Translocation</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="47"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="113"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="141"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="166"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CBF82532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="1090" mass="118727" checksum="2E8A02F2510468DC" modified="2009-11-03" version="1">MSFPTFNFGGNNGLATPGKSRNIFGNGEPPSPSNSFTPQGPPPSTIYGGSQMSARSPANSNPIFNRSELLNDSIFGSSVDSPDFASRTKQTAAAKRFTASESLFDVSRGPSFDESTNWGASNGFQPHMSGGLGADDGKSMEEDEDEDEAEQTGKTRGSGLNFLDSHMSSTGPSSIPAQRKPIYANPGNAKRPKLDEKWANQSPLRNAKLSPKKNSTIPAIVRNFAARTRKATVDEPFDFIIRTEDEISRMYEETRQTQYNNEYLQETIGKICADLSTVWYNSSESKASGTVIGPGDNAANSTKAGFLGALLLQLHHPPATKSTGFPNTFGLAAPRYTFGGRSASAPIPKVLLDWLNVNKPLSDEITALKQVEPDPTASPSFWEIVIAAVLRGQLSEASQILRSADFNYARSALEDGLPQAGYRGVQLQNIQRCINKALQVLEACPSVHNDNWDARDAEWSLYRKRVHTAISDLEEFAEGEEQPAPAPATGNTFQAINFGLGSNPFQGPSFTESARMAESRVPWTIYQNLRSVYRIILGDPAAIMNYAESWVEATIGLTVWWDGEDDEEASPPPFLRRGQSPSNDPYLRRLSLAFKHATSTEKDEKGFRYNSLSGIEVGLAAVFEGDVAGVLELLQTWSLCVAAAVAEISSVGGWLETKSNAKPPGLSDNDLMVLSYNQNDAPAGVSRDDVLSAYATGLSERPSIGNEHEGREGWELALEVLSRLDDSQKMQKSVSELLDKLPLDTAEQMDKVVLLCSELGLNKEGRRVSERYGDLTVSNSEEYGLALVCYARAHNRRKVKSVVDLLISYSLVQSRAYPASSDLDEQLRTLIREPKTCLSAIAHADEEAASILQFYFSGYATLRRFYETRDEAVNLPAGQKPRYKPLARRRAAAQALVAVISSAADSIYGGLYDPDRDSAIQVDGLLALLGEALPFVHQSSSILNPSQQFAILSAIEDLETVTPRVYAQCEECFRSTLLEYYSKQAGKASDSYVLPPSPRALLKKSVSSLTASSTFSIIGSDMLGARTRSSSGSAEGSGVLVPRDCEKTPLVREWDWRAGLPEDTKGEDVLRMLRLGLANGLTLEALGRAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>C8VLL1</accession>
    <name>C8VLL1_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cytochrome P450, putative (Eurofung)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ANIA_08905</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF84691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468605.1">
        <property type="nucleotide sequence ID" value="XM_050612719.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VLL1"/>
    <dbReference type="GeneID" id="2868141"/>
    <dbReference type="KEGG" id="ani:ANIA_08905"/>
    <dbReference type="eggNOG" id="KOG0157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_14_2_1"/>
    <dbReference type="InParanoid" id="C8VLL1"/>
    <dbReference type="OMA" id="AVKEIYC"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11059">
        <property type="entry name" value="CYP_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000186">
        <property type="entry name" value="Cytochrome P450, putative (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF164">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002992232" evidence="3">
        <location>
            <begin position="22"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="2">
        <location>
            <position position="412"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBF84691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="468" mass="53481" checksum="35F6876045BB8ECB" modified="2009-11-03" version="1">MLTFYLAASIIVTVLFMRRLCSPIAKLPGPWYATFTSWVLKYHEFTSNRRLFIHDLHKKYGSTVRIAPNEISFASLEAIKEIYGSGGSGYDKTELYDLFRQFGIKTMFSTLDKHSHSQRKRELADRYAMSNILREEHVSAIVDRARAVVSRCAASAESVDVYVWLHCYALDGVTNFMFSPGGLHSLDSEHDFKIMEELTYHQSLQKNLLHYYLPTVAAYFPPCLTPRRSPKTNEYVLKMCAQQLPSQHSLVAKLARKDSPLNHTQVAAECKDHMAAGIDTTGDGLCFLMWKLSQPHNIRFQERLWEELRTARPDIPLDKLPYLDAVVKEGLRCAPPIPMSFPRYVPTGGRSIDGHFVPEKTIVSCQPYTVHRLDENVFPEPDSFNPDRWMVEKGAVERNRLFFAFSTGGRGCTGRNLALVEMKILLREVYSRFRTTVAKDMHGCMDIDDQIISSRPLGQTCKLRFSET</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>C8VM53</accession>
    <name>C8VM53_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">C2H2 finger domain protein, putative (AFU_orthologue AFUA_8G04290)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_01438</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF84858.1"/>
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        <property type="nucleotide sequence ID" value="XM_050612756.1"/>
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    <dbReference type="KEGG" id="ani:ANIA_01438"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
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        <property type="component" value="Chromosome VII"/>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
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            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001307">
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    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_050613087.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VPW1"/>
    <dbReference type="GeneID" id="74896950"/>
    <dbReference type="KEGG" id="ani:ANIA_11349"/>
    <dbReference type="HOGENOM" id="CLU_2704783_0_0_1"/>
    <dbReference type="InParanoid" id="C8VPW1"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF87125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="73" mass="8098" checksum="F62F2C8826D5BE9E" modified="2009-11-03" version="1">MPNIIEGLGLKASPRTPMRFDVVGFTPHRSLEAAGDIMPEILVVGWLAANEELARSPDTIEHTGRHHRAFTHE</sequence>
</entry>
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    <accession>C8VQB4</accession>
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    <reference evidence="15" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
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            <dbReference type="DOI" id="10.1038/nature04341"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="15">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
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    <reference evidence="15" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10 11">Belongs to the peptidase C12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="11"/>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF87294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468951.1">
        <property type="nucleotide sequence ID" value="XM_050613110.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VQB4"/>
    <dbReference type="STRING" id="227321.C8VQB4"/>
    <dbReference type="GeneID" id="2867852"/>
    <dbReference type="KEGG" id="ani:ANIA_11218"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN11218"/>
    <dbReference type="eggNOG" id="KOG0065">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1415">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1320878_0_0_1"/>
    <dbReference type="InParanoid" id="C8VQB4"/>
    <dbReference type="OrthoDB" id="427186at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.532.10">
        <property type="entry name" value="Peptidase C12, ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001578">
        <property type="entry name" value="Peptidase_C12_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036959">
        <property type="entry name" value="Peptidase_C12_UCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589:SF41">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01088">
        <property type="entry name" value="Peptidase_C12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00707">
        <property type="entry name" value="UBCTHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52048">
        <property type="entry name" value="UCH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 11" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 11" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="162"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="UCH catalytic" evidence="13">
        <location>
            <begin position="1"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS52048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CBF87294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="208" mass="22507" checksum="4E48A36796A2E872" modified="2009-11-03" version="1">MNQLATKLGLSSELQFYDVYSLNEPEQLAHIPRPAFALLVVIPLTPAWDESRKAEDADKEPYTGSGTDEPVIWYKQTIGHACGLIGLLHSLFNGPAVDLSSLTPLLVVLYCLSTKAFSFFHPSAFCIAQIAADTPVIIFRISIVAIVLYFMVGLTISASALFAYGLILFAGTMCMTAMFRAIGAAFDSFDAASRKCTHDSSGFSGLIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>C8VQU8</accession>
    <name>C8VQU8_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">General amidase, putative (AFU_orthologue AFUA_1G14530)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ANIA_00783</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the amidase family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF88792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050469134.1">
        <property type="nucleotide sequence ID" value="XM_050613307.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VQU8"/>
    <dbReference type="STRING" id="227321.C8VQU8"/>
    <dbReference type="GeneID" id="2876560"/>
    <dbReference type="KEGG" id="ani:ANIA_00783"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN0783"/>
    <dbReference type="eggNOG" id="KOG1212">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009600_9_1_1"/>
    <dbReference type="InParanoid" id="C8VQU8"/>
    <dbReference type="OMA" id="EMMKMWT"/>
    <dbReference type="OrthoDB" id="6428749at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043605">
        <property type="term" value="P:amide catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072:SF6">
        <property type="entry name" value="AMIDASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G14530)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072">
        <property type="entry name" value="AMIDASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001221">
        <property type="entry name" value="Amidase_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="5">
        <location>
            <begin position="98"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="3">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="3">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="3">
        <location>
            <position position="204"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="201"/>
            <end position="204"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBF88792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="533" mass="58039" checksum="87B361C7F3995AA1" modified="2009-11-03" version="1">MEYSSIAQRKQDQLWERIPQEWRLAQDKIPPGMHSPAESVTNVQYDRVNVMDIPRSCGLLSPKEIEITERWDITACSPTSSRIGRPPPPHRLPNWPSSGLPVSVKDSFNIRGVDSTVGIAALALHPSEKDAPLVSLLQSLGAIIIAKTNVPQTMGALDSANHVFGRTLNPRNRQLTAGGSTGGEGALLALRGSMIGFGTDIGGSIRVPAMCNGLYGFKPSQGRVPYGGQTDGQPVAKGRISIQAVAGPIAHSVVDINAVMTHLIPRAQWFGEDCIPGAWPSPLSSFGRKSRPITIGVLPSDGIVEPLPPISKVLNEVAAALRRTPGVNVVQLPVPKALPKCQALAGRLMGVDGGIKMLDLVESTGETLIPWLKGRTKRGRPLLLSQLAELQATRGDVELELRRELWMYGSTGHEQTVDAIIHPVAPHPVPELDRYNAVGYTSSFVLLDYPAGTVPVRNFGRDDLENGKEMEARVIGSWDKANRELWNEKTVDRTVYLDSPLSVQVITPKQHDYELYQAMELIDRAIKTDRSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>C8VSF8</accession>
    <name>C8VSF8_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Mitochondrial import inner membrane translocase subunit TIM44</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">ANIA_01281</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="16">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Tim44 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF87801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050469011.1">
        <property type="nucleotide sequence ID" value="XM_050613176.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VSF8"/>
    <dbReference type="FunCoup" id="C8VSF8">
        <property type="interactions" value="982"/>
    </dbReference>
    <dbReference type="STRING" id="227321.C8VSF8"/>
    <dbReference type="GeneID" id="2877060"/>
    <dbReference type="KEGG" id="ani:ANIA_01281"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN1281"/>
    <dbReference type="eggNOG" id="KOG2580">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020932_2_0_1"/>
    <dbReference type="InParanoid" id="C8VSF8"/>
    <dbReference type="OMA" id="NFQMEPF"/>
    <dbReference type="OrthoDB" id="10265990at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.240:FF:000002">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit TIM44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039544">
        <property type="entry name" value="Tim44-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007379">
        <property type="entry name" value="Tim44-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10721">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10721:SF1">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04280">
        <property type="entry name" value="Tim44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00978">
        <property type="entry name" value="Tim44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Tim44-like" evidence="14">
        <location>
            <begin position="354"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="74"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="270"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="84"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="270"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00074309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CBF87801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="514" mass="57886" checksum="753AC3B8C389898C" modified="2009-11-03" version="1">MIAATRLPATARVAALRSQVLALRATGGNSAALQRSLIQSPLYATSRSIDCAKSPVSRLLSPYASLHLTRSFHVGTPRLQQKQEQTEKKSEETKQEKNEESKDEDKSEQKKEDKEDAPPPPPHGDKSPWQVFRDTLQQEFKASKEWNESTKALASSAHQFAENENVKRARAAYEAAQGAASSRTASALKGTGRVIGKSASWTWNTPVVKGLRKGVNATTSGIEKATRPVRETEVYKTAVGGVKQAIDDGSSSRYGGWTEKEERRRMRQLREQEELKSGRRKAEPMVEDPNAGTNITLHKDSAWKESWREFKDSNPMMQKLFSLKETYNESENPLISTARSISDRIAGFFAENETAQVVKKFREMDPNFQMEAFLREMREYILPEVLDAYVKGDIETLKLWLSDAQFHVYEALTKQITTAGLKSDGRILDIRGVDVMSARMLDPGDIPVFVVMCRTQEVHVYRNVKTNELAAGMEDKVQLVNYVMGLTRIPEDVNNPETKGWRLIELQKAARDYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-12-14" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>G5EAZ9</accession>
    <accession>C8VHP0</accession>
    <name>G5EAZ9_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ANIA_03382</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF82819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_660986.1">
        <property type="nucleotide sequence ID" value="XM_655894.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G5EAZ9"/>
    <dbReference type="STRING" id="227321.G5EAZ9"/>
    <dbReference type="GeneID" id="2874363"/>
    <dbReference type="KEGG" id="ani:ANIA_03382"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN3382"/>
    <dbReference type="eggNOG" id="KOG2614">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009665_6_3_1"/>
    <dbReference type="InParanoid" id="G5EAZ9"/>
    <dbReference type="OMA" id="EIYEWND"/>
    <dbReference type="OrthoDB" id="417877at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000153">
        <property type="entry name" value="Salicylate hydroxylase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051104">
        <property type="entry name" value="FAD_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720:SF3">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720">
        <property type="entry name" value="HYDROXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01460)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="8">
        <location>
            <begin position="347"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBF82819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="473" mass="52076" checksum="2AB046302F13E567" modified="2011-12-14" version="1">MSASTPTVNGTNEPISIAIIGAGIIGTVLALGLTRRKDAFPLPVNVRVYEQSATLRAPGAGIAFTANARKCLALIDPVLEECATAVGTANGEDPERPNNYMQFVDGYTHRQEDVEVGQDLVGKKVYRLHAGRRGFEGCHRQEFLRGVLEHLNDDVVVLGKRLEEYSVLEQEKGKKGKLQMMFSDGSSAEADIVIGTDGLKSRVRQLLFGVDNPVSYPHYTHKIAYRALIPMPLAISRLGKSLALNQHMYGGPNAHLLTFPVANQKLMNVVGFVSDTNEWPLERSMTQPARKDEIVDAFRCWGPTVREIIDLLGEVDSEWLDKWAVFDHFDHPAPYYASVVSGKDKGKGLVCVAGDAAHASSPHHGAGAGIGVEDALALITVIEKAIRDIHSEQRTKDDALTAALKAYSDVRYERSQWLVRSSREVCGTYEWSNPEIGGDLEKGFEDVKERSHRIWDFDIDGMLTDLGSIYQSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="120" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AQG1</accession>
    <accession>C8V3D7</accession>
    <name>Q5AQG1_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein uL13m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ANIA_09469</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL13 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF70470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_868851.1">
        <property type="nucleotide sequence ID" value="XM_863758.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AQG1"/>
    <dbReference type="FunCoup" id="Q5AQG1">
        <property type="interactions" value="707"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5AQG1"/>
    <dbReference type="GeneID" id="3684066"/>
    <dbReference type="KEGG" id="ani:ANIA_09469"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN9469"/>
    <dbReference type="eggNOG" id="KOG3203">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082184_1_1_1"/>
    <dbReference type="InParanoid" id="Q5AQG1"/>
    <dbReference type="OMA" id="HKPIYTP"/>
    <dbReference type="OrthoDB" id="274622at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00392">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1180.10:FF:000007">
        <property type="entry name" value="50S ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1180.10">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01366">
        <property type="entry name" value="Ribosomal_uL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005822">
        <property type="entry name" value="Ribosomal_uL13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005823">
        <property type="entry name" value="Ribosomal_uL13_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036899">
        <property type="entry name" value="Ribosomal_uL13_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01066">
        <property type="entry name" value="rplM_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL13M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545">
        <property type="entry name" value="RIBOSOMAL PROTEIN L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00572">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002181">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52161">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 8" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00068950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBF70470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="166" mass="18537" checksum="88EA1D34F8275AFF" modified="2005-04-26" version="1">MSQTVGKTRLAYSRAWHLVDVGSDGRSLGRLASSIALILMGKNKPIYDPSTDCGDYVVAVGCHDLHTTGKKRFQKKYYTHTTRPGSLRSMTMDKMFEKWGGGEVLRRAVRGMLPKNRLRDKRLARLKTFEGVDHPYKDNIVRIGAPSNIGALPEVKAAFQEAKTSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="104" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AQG5</accession>
    <accession>C8VRV4</accession>
    <name>Q5AQG5_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">60S ribosomal protein L9, putative (AFU_orthologue AFUA_1G09100)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ANIA_09465</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL6 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF87624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_868847.1">
        <property type="nucleotide sequence ID" value="XM_863754.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AQG5"/>
    <dbReference type="FunCoup" id="Q5AQG5">
        <property type="interactions" value="895"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5AQG5"/>
    <dbReference type="GeneID" id="3684062"/>
    <dbReference type="KEGG" id="ani:ANIA_09465"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN9465"/>
    <dbReference type="eggNOG" id="KOG3255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065464_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AQG5"/>
    <dbReference type="OMA" id="YAHFPMK"/>
    <dbReference type="OrthoDB" id="10252633at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.930.12:FF:000003">
        <property type="entry name" value="60S ribosomal protein L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.930.12:FF:000004">
        <property type="entry name" value="60S ribosomal protein L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.930.12">
        <property type="entry name" value="Ribosomal protein L6, alpha-beta domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000702">
        <property type="entry name" value="Ribosomal_uL6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036789">
        <property type="entry name" value="Ribosomal_uL6-like_a/b-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020040">
        <property type="entry name" value="Ribosomal_uL6_a/b-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002359">
        <property type="entry name" value="Ribosomal_uL6_CS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655:SF16">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655">
        <property type="entry name" value="60S/50S RIBOSOMAL PROTEIN L6/L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00347">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002162">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56053">
        <property type="entry name" value="Ribosomal protein L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00700">
        <property type="entry name" value="RIBOSOMAL_L6_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL6 alpha-beta" evidence="4">
        <location>
            <begin position="12"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL6 alpha-beta" evidence="4">
        <location>
            <begin position="97"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBF87624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="192" mass="21784" checksum="F4D40E6F31A0ACA7" modified="2005-04-26" version="1">MRYIHSEETLPIPENVKVHIRSRVVTVEGPRGKLTKDLSHIAVTFGRPKKDVISIEMHHGSRKGVATLRTVRTLINNLIIGVTKGFKYKMRYVYAHFPINVNIEKNAETGQYDVEIRNFLGEKYVRRVVCQPGVEIIASPNVKDELQLSGNSLEAVSQSAADIQQICRVRNKDIRKFLDGLYVSEKGNIVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AQQ9</accession>
    <accession>C8VR76</accession>
    <name>Q5AQQ9_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ANIA_09371</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF87489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_682640.1">
        <property type="nucleotide sequence ID" value="XM_677548.1"/>
    </dbReference>
    <dbReference type="GeneID" id="2867844"/>
    <dbReference type="KEGG" id="ani:ANIA_09371"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN9371"/>
    <dbReference type="eggNOG" id="ENOG502RWXH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_241634_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AQQ9"/>
    <dbReference type="OMA" id="SSWHRMA"/>
    <dbReference type="OrthoDB" id="2549237at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF87489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="1630" mass="185450" checksum="8E081AF357908BF2" modified="2005-04-26" version="1">MIPEALQPRALLAPPRDLASHFRTLIAADSSMENLTFIDRCVLDQIHTEAIPSSVYEVWLSLACRYTPLFTVAALTKPSRGVRLAARHCARRLFLSSHWKERGWDFLGGAQGIKGILDILPLKEARLLLKIIFGRCQAIPDGKVVSVCVEEFLDLVEATDPWLSRSLLPHVSHLYAYCSAERVEDMLRSQSPKCPELLKYTSRFHTPLLRRIAIGKVDMPEEVRRKTLQQCQTALLNSKEPYDPIYYQDVQLTLNLSPGLLFGMDLLTALEREPEILRSHLSRALSRDIVQFWSISRFGGVKGTHEGLVAQCQKRRRLKDLSAYQIELEDCLIKRVLQVQDESFQNQGKNRRQFSETLNSLIRLVNIRGRKAFLQLLCRHCPTMDFDLTTWPPSQREQELMPCWDLDVLDRLRPDDSESLFGRSLHIYHCEEFLPSFDSRNPELKMPSWEAQCLLWASWESASPERNGFPITLKALGDMKQKSVRAREPAERLRWAISAVKLAARTSSIDIFAEIVEWTSRYIRDALVFPDLMYEIIDRCPLMLSCRAATQGEASVPRSDLEREAQTGHKIMEGLLKTCLLLLREPWARSSVSRITGRICNMFSAIVSRRMESVRDLARGESFTECELAEILLDPIIPVLMEYERQGNIKGQTDVRWSGPTGLLLSPCLFPRAPTLLELSFMDRLAKARDEFWQQHRSQHDPDVVKLSPGLPRGLAIQHLVYTSDWLYQVMKHPDHAPFLSSRANEVLFGAADTVMHAMEDKEAHVDGFVDCLGFIVRALLANDNPADRNRDVLRVWEHYSEILKPYPDYLGLFQDWLAAGIRHREHIGEALDTIQPPGPCLAVTPRISAVPSASEIDMIEWDPQDGDYPPSKKPFKDMKETLDKIPCTVLNCRMERGIPSQFPYVYARKPPAQPTPEYLSIWSPASDSQAKASQGSSHCIQESVVLAALLFLDTHTKDRGILRARFPDVDCPRYPPIRLAESFIASQTRDKLEKALSPPIDALRRSARRVPSQILRNLILSFLDTLEAEPNSPTYSALLFSTFDLIEILLSTDEPQLAVDIMIRVWKDFPGESSFHRKISLVKLGRVLFPEQGRKLMSQFAGYVCDALQAQQGQNQQQPKEKKGFIKVTTAKMLAQALAEADFLSQAGRMEILRKMFSSARHVDIRREIVNALLNLVGSCENPEPYKVFASIVASVAGPNERAATTEVEWEMAENPERGGPLPYVAPLTERPVLNSAFSAAFWSIPEKLRPEYVENVLLPLLQESSRQHTRWIAAMAARLGLSLSDLNITEDDIGPFIPDLTNKILWRWAEYLPESFLQQFHRPWALSYLHYESFARIDSALAVTAEAPLKDSNVRDHWENFFASLCGRPALYSLEKLLSPFVNGVSKAPNGLNTALILEEFEFCAELVIRNPVKYNRFFKKYILHPEYTLEPFRALRESRLKSVSDVKDSADKARIYHDLTDAMARLISVCETVRREGWSAAAYPVTLPSQFEYHVLLLPSPIYNPSASETHSAAEIFTSALVDLIIKYSADPTLLLKLDSFQSVLREIPSADLKACMLRLGCVWRELEKHDPIVICIRVKLALSLLDIMRSDKGFFKRDVDILGMIEEWKKSDVEFVRQIGWEVELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="115" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AQX8</accession>
    <accession>C8VQQ5</accession>
    <name>Q5AQX8_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_09302</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF87364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_682571.1">
        <property type="nucleotide sequence ID" value="XM_677479.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AQX8"/>
    <dbReference type="STRING" id="227321.Q5AQX8"/>
    <dbReference type="GeneID" id="2867877"/>
    <dbReference type="KEGG" id="ani:ANIA_09302"/>
    <dbReference type="eggNOG" id="KOG1187">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_402792_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AQX8"/>
    <dbReference type="OrthoDB" id="5986190at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="158"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="402"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF87364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="683" mass="80194" checksum="A8869F8F7F3A50E9" modified="2005-04-26" version="1">MDVPPHIQIRDRLYLKARDADNDYFPRSRIMSVFTTDDCLRKVYFCDCPLCRQDFRNPDNRRQTFDSQELLGQYATVYALLIYNYRPGLIRHFQRDRRTLDGTHFFTEDSLRFLDKEGVQLRSIIQDILNNQYKFHIRVIDRSREPITMHRGEVLPIRQNMEQTGQGSFGQVYGFEFAYDEYRGQGLRDITRFARKIFHRDTAGLDEWFNLLHFDRLQHPHLMSALAAFWHEDKFSIVFEEADLTLGAYLENGGHLYTHEALWNQVQGLADGLAYLHGRSGSVIAYHGDLKPANILIVRGVMKIADFGLLQVRYRSIANNLEVWSLESDTIASSRRIYGGPDHSNKALMDVWSFAAILSEISVFNLEGIQGLKRYRQRRFDDVQEATPSYKTYNFRHDTQMKASVSQTIDDLQQLVQNSEQQQTRISRFQRRFFNAGFFTLLRQMFSRDYADCPSSTHVSEELRRIHWQATLPLQEAVQRGNIWDDVSSGAVPNSPQRPNCRLTDCGILLFDWKEGKSLLVQCVLYDYNDVNIYILQERSEVMRLNQEYPSFDPEYTDRSSNRPSLRATLQQWDGRRYTFEFVELRELLILQAAMTKQYVFNFIPFSGRRRLVLELNRAVVQLWSEKPLREDQILWPATPRVVNPRMHIAVICRNEKKLLLIKGIWAPRLINFADLNCHGTER</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="101" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ARF8</accession>
    <accession>C8VK79</accession>
    <name>Q5ARF8_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ANIA_09122</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF82504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_682391.1">
        <property type="nucleotide sequence ID" value="XM_677299.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ARF8"/>
    <dbReference type="GeneID" id="2868060"/>
    <dbReference type="KEGG" id="ani:ANIA_09122"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN9122"/>
    <dbReference type="eggNOG" id="ENOG502S3DF">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_012494_9_0_1"/>
    <dbReference type="InParanoid" id="Q5ARF8"/>
    <dbReference type="OMA" id="DHTFAMG"/>
    <dbReference type="OrthoDB" id="19653at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
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    <dbReference type="InterPro" id="IPR049492">
        <property type="entry name" value="BD-FAE-like_dom"/>
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    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
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    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF3">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF20434">
        <property type="entry name" value="BD-FAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BD-FAE-like" evidence="3">
        <location>
            <begin position="28"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="2">
        <location>
            <begin position="260"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBF82504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="344" mass="38028" checksum="1DCB090248BD366B" modified="2005-04-26" version="1">MTPLTVPSPPPPLTTSYKQINSSTITADIYLPPSQPSQSSNEPIHYPVLINIHGGAFMLGHSRMVSLAQISDCLARNWIVAVPNHRLCPGVDVLSGPMADIRDFLAWIYADQDGLNAFLEKQDRDGNGNGKGKYRVAKDRVMAFGTSSGGFLALSLGYDVPRPPRAILNFYGAVHFTHPSWTQPLAHVKSMLPPFEPEFLAKVYEEFPIPTTSGISLEGQSGASNKPDFSRPRDAFALTQIANGNVLRVIFPPECGDIRSIDPVVRVQKGEGFPPTFIVHGDRDRMVSIEVSRELYQALKEKGIECGIVEVEGEDHTFALGMEVGSRTWERQREGFNWIERVIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ARV9</accession>
    <accession>C8VL82</accession>
    <name>Q5ARV9_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Integral membrane protein (AFU_orthologue AFUA_5G13725)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ANIA_08971</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF84542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_682240.1">
        <property type="nucleotide sequence ID" value="XM_677148.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ARV9"/>
    <dbReference type="GeneID" id="2868195"/>
    <dbReference type="KEGG" id="ani:ANIA_08971"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN8971"/>
    <dbReference type="eggNOG" id="ENOG502SHS7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028200_3_7_1"/>
    <dbReference type="InParanoid" id="Q5ARV9"/>
    <dbReference type="OMA" id="ITATRFW"/>
    <dbReference type="OrthoDB" id="4682787at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF164">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="14"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="49"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="92"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="211"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="33"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="303"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="308"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBF84542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="423" mass="47173" checksum="C3872FC9DD4D4DDB" modified="2005-04-26" version="1">MLESEPGLVVDHGWVLYAASWPLFGICFLIISLRLWVRAHMVRSLGWDDAFMILAFLCAAINTILVTISVQYGTGRHASNLTEYQQSQSIKYQVLSAGFHVMSTNWGKVSVALFLIRIISEVKNHKLGMYALIIVMTIINTGAVITIFAQCQPTAAIWDHSLAGPQACWPPDTQKKYSFFQAAASALTDLILAIYPLFTIKDLQMPTKVKLGLGFVLSLGLVAMVAAIIKATHLPDMASYEDYTWDTINLTIWVSLEQYLIILAACIPALTPLFNIIVRRASNRSKSKSKSMPNDLLKGDSVTVQSLSRKHKHGSRSRGRSRDFALTLDSNSSQHQQYNPFARVGREYVEYPLTWTTTTMHTATDLHHPADGSDSETPISGFHEEPEMPTGILRTTDFRLEAVSNSRNSAVRWQIAKPILQDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="101" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ASB5</accession>
    <accession>C8V9M1</accession>
    <name>Q5ASB5_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Hypothetical oxidoreductase (Eurofung)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ANIA_08815</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF77964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_682084.1">
        <property type="nucleotide sequence ID" value="XM_676992.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ASB5"/>
    <dbReference type="GeneID" id="2868316"/>
    <dbReference type="KEGG" id="ani:ANIA_08815"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN8815"/>
    <dbReference type="eggNOG" id="ENOG502QPMY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044876_6_0_1"/>
    <dbReference type="InParanoid" id="Q5ASB5"/>
    <dbReference type="OMA" id="TPYPENM"/>
    <dbReference type="OrthoDB" id="419598at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009807">
        <property type="term" value="P:lignan biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd05259">
        <property type="entry name" value="PCBER_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045312">
        <property type="entry name" value="PCBER-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF9">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="4">
        <location>
            <begin position="4"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="329"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBF77964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="359" mass="40478" checksum="DFBB29B003FA6497" modified="2005-04-26" version="1">MSRTTVLLIGAAGETGGSIAAGLLEHPTFEIHALIRPRSAQKPAVLALQDKGVHIRKCDLKSSEEELEKALSDIDVVISCVGSAEQQDQIPIANAAKKAGVKRFIPCGFITVAPPGGIMWLRDEKEAVYNHIKQLHLPYTIIDVGWWYQLAYPRLESGKLDYAMTTSNNEIVGDGNTPLALTDLRDIGRYVARIITDDRTLNKMVFAYNTVLTQNEIFGLLEEISGEQITRNYISEELVQNRVLAARQSSETYPFDPVKFIPRYLAEYQLSWGIRGDNNPEYAKYLGYLLAKDLYPEFQPIDFKDYLIEVFQGTAKGIYTDRTISKAQQRMFPRSESTDSLQGRFFPRTESSDSLYMSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ASM2</accession>
    <accession>C8VA38</accession>
    <name>Q5ASM2_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ANIA_08708</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF78191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_681977.1">
        <property type="nucleotide sequence ID" value="XM_676885.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ASM2"/>
    <dbReference type="GeneID" id="2868534"/>
    <dbReference type="KEGG" id="ani:ANIA_08708"/>
    <dbReference type="HOGENOM" id="CLU_1704220_0_0_1"/>
    <dbReference type="InParanoid" id="Q5ASM2"/>
    <dbReference type="OMA" id="HRNIRQR"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF78191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="154" mass="17527" checksum="66E49173C896675F" modified="2005-04-26" version="1">MQYFGEQSRLIATQQSLPTVGKLALRCKSTIHVKRHQVTVESVQYVDEAFSLYGQLRGDWLPSRFRKPSLCEFVGGVVKEMGSSVKSSDLEMRGCATAIPLLPPTLRHSFSNSINHRNIRQRPALRLRIKRPSQQSFYDKRINRCQSSGLAAHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ATP4</accession>
    <accession>C8VE28</accession>
    <name>Q5ATP4_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Alcohol dehydrogenase-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_08336</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF80333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_681605.1">
        <property type="nucleotide sequence ID" value="XM_676513.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ATP4"/>
    <dbReference type="GeneID" id="2868835"/>
    <dbReference type="KEGG" id="ani:ANIA_08336"/>
    <dbReference type="eggNOG" id="KOG1198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1326359_0_0_1"/>
    <dbReference type="InParanoid" id="Q5ATP4"/>
    <dbReference type="OMA" id="QWAGESD"/>
    <dbReference type="OrthoDB" id="3509362at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052711">
        <property type="entry name" value="Zinc_ADH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C1773.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="1">
        <location>
            <begin position="70"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF80333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="207" mass="22080" checksum="9FC1FBD7D520C401" modified="2005-04-26" version="1">MSLTVIRIAGERNSVRNLKALRDKPRGLAQGLAQWAGESDGVLREYLALPCIGAVKLPKDSPLRFSHTGGVSITGLLVAKAAGATTIVTSSSDEKLESIMAKFGFDYGVNYKRYPEWSKEVLRLTGGEGVDYVLENGGSGTIAESINAVKMGGNVSVIGLLSQAKEMPDVLAWRSLKAQWFAVSQLILPSSCRRSSALSAVKGCVYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="117" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AU20</accession>
    <accession>C8V775</accession>
    <name>Q5AU20_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SH3 domain protein (Cyk3), putative (AFU_orthologue AFUA_5G03400)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ANIA_08210</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF74116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_681479.1">
        <property type="nucleotide sequence ID" value="XM_676387.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q5AU20">
        <property type="interactions" value="33"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5AU20"/>
    <dbReference type="GeneID" id="2869292"/>
    <dbReference type="KEGG" id="ani:ANIA_08210"/>
    <dbReference type="eggNOG" id="KOG4575">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002511_0_1_1"/>
    <dbReference type="InParanoid" id="Q5AU20"/>
    <dbReference type="OMA" id="MATEWAN"/>
    <dbReference type="OrthoDB" id="6129702at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd11889">
        <property type="entry name" value="SH3_Cyk3p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000062">
        <property type="entry name" value="1-aminocyclopropane-1-carboxylate deaminase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000168">
        <property type="entry name" value="SH3 domain protein (Cyk3)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.620.30:FF:000005">
        <property type="entry name" value="SH3 domain protein (Cyk3), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.620.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052557">
        <property type="entry name" value="CAP/Cytokinesis_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035553">
        <property type="entry name" value="Cyk3_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056409">
        <property type="entry name" value="Ig_CYK3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46333">
        <property type="entry name" value="CYTOKINESIS PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46333:SF2">
        <property type="entry name" value="CYTOKINESIS PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24584">
        <property type="entry name" value="Ig_CYK3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00460">
        <property type="entry name" value="TGc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="11"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="116"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="481"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="608"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="704"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1173"/>
            <end position="1192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1385"/>
            <end position="1406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="118"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="154"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="203"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="232"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="272"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="302"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="481"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="548"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="568"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="584"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="639"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="704"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1174"/>
            <end position="1187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1385"/>
            <end position="1400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBF74116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="1789" mass="195134" checksum="207CF9A9CF6191E3" modified="2005-04-26" version="1">MAAPTPQLPTRFPCWCRAIYSWGGEAKSDLGFIEGDLIECLNAGDGQWWMGRLRRDRRMVGLFPSNFVQLLGEDFVPVTRATSPMLPAAASPITNPTSAPKKQKTVFRKPFQAHKEALAPSGSGGSPSSTSLVGSTIPQTPPRDGSLSRRTKTGRTPTRANRQQSSLSRPLSIARPPSRGVSPHPPPEPTPQQHDISSRSRSRPPSRAVSPRPQLPEVTHSSPLVSPAGPTYAQTSHYPSHASSSRPQLPDFGRHSPLVSPSFPMYSHVQDTHSWSRSASPRPQLPEITHHSPLSPSVPMHNHSQLSHQSSREISPLQLTEREDSPPPPPPPPHRVAVQRQPSPGPAVPRQLDMNDRYVVFTRTPSPAGHSDANGQTPSPLRDAMEDVMTSLEDMGMPRDSRSPSPQPEFDNPWSPAAFDSLRESRHPQRNNRPLTSLGFEGEKEFYHSDAVHRNSVYTHDPFIEGPPQINNYVQRMESRLRQMQEQGRRGSEDIQPPVENSEEDDDMPPPPPPRHGSYHGRHNSIPAHLPSLRSRRSGHDLRNDMLNRSFTKSSNTTNSSSGVHSNATNQTSSTDRTSQSLMSGPSAGGFSATSAGSYARRGIAAGERPSTAVDAVRSRGFSDLTRMPRPESPMSGISYHSSHNTSRQGASSAIPWSTSATTPEEPNSVFGGLATPKAKKQGFFKKILESAKTGAANARSSIAVGQSGGSFSPTKGRAISPIRSSHSHRDTAAREMGTGNNPMDWVQVRRDVNRASSPSRNERIERAERCQMMDHPVIYAVEELYETAEGEESIDGLPISEPTDFGNVNLTLVDKSARFVNSLPPMTNPLSLAQGYVCRPYKSDVQRLRAIFTWVSEKIAWDEPIEDADIDLKRVLQTKRGCAQEVAYLVREMCAAVGIHADAIEGFLKPPGEVFDLDSLSRPNHWWNAVLVDGDWRFMDCSLANPTNPIRNQFVTTNTTVAESWYFLARPLELCYTHVPLEPEGQHICPPISPDVLLALPTVCPTYFKMGLQFPDYDTSVFRIEGLEVLQVRILVPADVECAAEVEAPGFARDADGDFFESGEIVRKRALVQPDWVNGQKRITIKAVLPGDEGQGMVKVYAGRKGLMHSSRDIPHPLAFALPIIHTGENPPYEFVLRHPTPHAQRHDLYIIQPQCAKLAVNNTFVFAVRQHPSSPTPQTSSNENSFSGRISPSVFSRPASALSMVSSSAGGSTVSTVSNEFSASTSAISSTRSNSGREKPAKLAIQSPSGKILRLTRKADHMISSPKTSDSPSECTADGSVWETVIKIGEGASPLQQQAFEFTPLLIPRDDIWHLALPRLASFEWTCTYLIYIEASKREMSPRLNLPDPFATIPRVSLLYPFSSPIHPLQSLSGLASAPAPASASASASTTHSAPGSTRSQGARTEGIHVSLYAKREDHSSPLACAGNKYRKLEYIVPDILSSSPRYGAGIAADVPTPIHGKGKVTTLVTEGAIQSNHTVQVASVASRIGLESVVLLHKGTGGGLASAKDKAAFLRTGNVQIVKLLGAEVRMFEKPVAPKTQDDIVEEVLNNLRAEGKVPYWIPSGASLHPLGGLGYARCAFEIAAQEKDILGSPNDRGSGGYGIKQPRFDYIFVACGSGSTVGGLIAGFKLLEKMENSQPHEQTRGERKRRVIGILTSPTMRKRYHEERILRFARGAGKLIGLNPQTDITMDDVVLDDRFAGERYGVLDAKTNDMLSLMAEKEEVILDPVYTAKVARGMMHWVAEGEIEKDLLASPATYRGQDGEQVNVLFIHTGGQSALGAYAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="112" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AUI4</accession>
    <accession>C8V611</accession>
    <name>Q5AUI4_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">feruloyl esterase</fullName>
            <ecNumber evidence="1">3.1.1.73</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Ferulic acid esterase A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ANIA_08046</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>feruloyl-polysaccharide + H2O = ferulate + polysaccharide.</text>
            <dbReference type="EC" id="3.1.1.73"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the AB hydrolase superfamily. FaeA family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.73" evidence="1"/>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF73771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_681315.1">
        <property type="nucleotide sequence ID" value="XM_676223.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AUI4"/>
    <dbReference type="FunCoup" id="Q5AUI4">
        <property type="interactions" value="6"/>
    </dbReference>
    <dbReference type="ESTHER" id="emeni-q5aui4">
        <property type="family name" value="Lipase_3"/>
    </dbReference>
    <dbReference type="GeneID" id="2869196"/>
    <dbReference type="KEGG" id="ani:ANIA_08046"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN8046"/>
    <dbReference type="eggNOG" id="KOG4569">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032957_1_0_1"/>
    <dbReference type="InParanoid" id="Q5AUI4"/>
    <dbReference type="OMA" id="YTAAAYC"/>
    <dbReference type="OrthoDB" id="426718at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030600">
        <property type="term" value="F:feruloyl esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051299">
        <property type="entry name" value="AB_hydrolase_lip/est"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005592">
        <property type="entry name" value="Mono/diacylglycerol_lipase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46640:SF1">
        <property type="entry name" value="FUNGAL LIPASE-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46640">
        <property type="entry name" value="TRIACYLGLYCEROL LIPASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G06510)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03893">
        <property type="entry name" value="Lipase3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030175728" description="feruloyl esterase" evidence="8">
        <location>
            <begin position="20"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="Mono-/di-acylglycerol lipase N-terminal" evidence="10">
        <location>
            <begin position="10"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal lipase-type" evidence="9">
        <location>
            <begin position="104"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00041313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CBF73771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="294" mass="31291" checksum="3209230E69FCD37E" modified="2005-04-26" version="1">MIRLGYSAIFVALAGLAVAAPAPLNRRDVSTEALNQLTLFAEYSAASYCTPNIGSVGDKLTCASGNCPTVEAADTTTLAEFYQENEYGDVAGFLAADTTNELLVLSFRGSRTIDTWIANLDFGLESVEEICSGCKAHGGFWKAWQVVADSLTSAIESATATYPGYAIVFTGHSFGGALATLGAAQLRKAGYAIELYPYGSPRVGNEALAQYITDQGANYRVTHTNDIVPRLPPMLLGFSHLSPEYWITSDNEVTPTTTDIQVIEGVGSRDGNAGEAAQSVEAHSWYLIDITACQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AUP0</accession>
    <accession>C8V5L1</accession>
    <name>Q5AUP0_EMENI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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        <name evidence="2" type="ORF">ANIA_07990</name>
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        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
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    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
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            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF73662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_681259.1">
        <property type="nucleotide sequence ID" value="XM_676167.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AUP0"/>
    <dbReference type="STRING" id="227321.Q5AUP0"/>
    <dbReference type="GeneID" id="2868951"/>
    <dbReference type="KEGG" id="ani:ANIA_07990"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN7990"/>
    <dbReference type="HOGENOM" id="CLU_1886446_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AUP0"/>
    <dbReference type="OMA" id="LPGWETM"/>
    <dbReference type="OrthoDB" id="4504900at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF73662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="140" mass="14075" checksum="8D2C753222A4F2C9" modified="2005-04-26" version="1">MSSLQGKGMSSSDNQPTTSTRGGASAHPTPANNSGGGAGWGDSGLLKGGLEGVSNRLSSTSGESHSGKISSLNGELSSLKEQKMAGEQRYRQDIEESGGTVPKSSDHSDASFMTGKPGGAGTLPGWETAKGALNSMMGNE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2016-11-30" modified="2026-01-28" version="115" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AUW6</accession>
    <accession>C8V4V4</accession>
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        <recommendedName>
            <fullName evidence="8">Dehydrogenase orsE</fullName>
            <ecNumber evidence="9">1.-.-.-</ecNumber>
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        <alternativeName>
            <fullName evidence="9">Enoyl reductase orsE</fullName>
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        <alternativeName>
            <fullName evidence="7">Orsellinic acid/F9775 biosynthesis cluster protein E</fullName>
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    <gene>
        <name evidence="7" type="primary">orsE</name>
        <name type="ORF">AN7914</name>
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        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2009" name="Proc. Natl. Acad. Sci. U.S.A." volume="106" first="14558" last="14563">
            <title>Intimate bacterial-fungal interaction triggers biosynthesis of archetypal polyketides in Aspergillus nidulans.</title>
            <authorList>
                <person name="Schroeckh V."/>
                <person name="Scherlach K."/>
                <person name="Nuetzmann H.W."/>
                <person name="Shelest E."/>
                <person name="Schmidt-Heck W."/>
                <person name="Schuemann J."/>
                <person name="Martin K."/>
                <person name="Hertweck C."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="19666480"/>
            <dbReference type="DOI" id="10.1073/pnas.0901870106"/>
        </citation>
        <scope>IDENTIFICATION OF THE ORS CLUSTER</scope>
        <scope>FUNCTION</scope>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2010" name="Mol. Biosyst." volume="6" first="587" last="593">
            <title>Molecular genetic analysis of the orsellinic acid/F9775 gene cluster of Aspergillus nidulans.</title>
            <authorList>
                <person name="Sanchez J.F."/>
                <person name="Chiang Y.M."/>
                <person name="Szewczyk E."/>
                <person name="Davidson A.D."/>
                <person name="Ahuja M."/>
                <person name="Elizabeth Oakley C."/>
                <person name="Woo Bok J."/>
                <person name="Keller N."/>
                <person name="Oakley B.R."/>
                <person name="Wang C.C."/>
            </authorList>
            <dbReference type="PubMed" id="20174687"/>
            <dbReference type="DOI" id="10.1039/b904541d"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2013" name="Appl. Environ. Microbiol." volume="79" first="6102" last="6109">
            <title>Distinct amino acids of histone H3 control secondary metabolism in Aspergillus nidulans.</title>
            <authorList>
                <person name="Nuetzmann H.W."/>
                <person name="Fischer J."/>
                <person name="Scherlach K."/>
                <person name="Hertweck C."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="23892751"/>
            <dbReference type="DOI" id="10.1128/AEM.01578-13"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2013" name="Mol. Microbiol." volume="89" first="963" last="974">
            <title>VeA and MvlA repression of the cryptic orsellinic acid gene cluster in Aspergillus nidulans involves histone 3 acetylation.</title>
            <authorList>
                <person name="Bok J.W."/>
                <person name="Soukup A.A."/>
                <person name="Chadwick E."/>
                <person name="Chiang Y.M."/>
                <person name="Wang C.C."/>
                <person name="Keller N.P."/>
            </authorList>
            <dbReference type="PubMed" id="23841751"/>
            <dbReference type="DOI" id="10.1111/mmi.12326"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="3 4">Dehydrogenase; part of the gene cluster that mediates the biosynthesis of orsellinic acid, as well as of the cathepsin K inhibitors F9775 A and F9775 B (PubMed:19666480, PubMed:20174687). The non-reducing polyketide synthase orsA produces orsellinic acid by condensing acetyl-CoA with 3 malonyl-CoA units (PubMed:19666480, PubMed:20174687). Further modifications by the decarboxylase orsB and the tyrosinase-like protein orsC lead to the production of F9775 A and F9775 B (PubMed:20174687). The functions of orsD and orsE remain unclear since only orsB and orsC are required to convert orsellinic acid into F9775 A and F9775 B (PubMed:20174687).</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="induction">
        <text evidence="3 5 6">Expression is induced by an intimate physical interaction of the fungal mycelia with the bacterium Streptomyces hygroscopicus (PubMed:19666480). Expression is repressed by VeA and MvlA via histone 3 acetylation by the SAGA/ADA complex (PubMed:23841751, PubMed:23892751).</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="9"/>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF73513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AACD01000135">
        <property type="protein sequence ID" value="EAA59568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_681183.1">
        <property type="nucleotide sequence ID" value="XM_676091.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AUW6"/>
    <dbReference type="SMR" id="Q5AUW6"/>
    <dbReference type="STRING" id="227321.Q5AUW6"/>
    <dbReference type="EnsemblFungi" id="CBF73513">
        <property type="protein sequence ID" value="CBF73513"/>
        <property type="gene ID" value="ANIA_07914"/>
    </dbReference>
    <dbReference type="KEGG" id="ani:ANIA_07914"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN7914"/>
    <dbReference type="eggNOG" id="KOG1198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_16_5_1"/>
    <dbReference type="InParanoid" id="Q5AUW6"/>
    <dbReference type="OMA" id="LDCHMQD"/>
    <dbReference type="OrthoDB" id="48317at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035925">
        <property type="term" value="F:mRNA 3'-UTR AU-rich region binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070402">
        <property type="term" value="F:NADPH binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003960">
        <property type="term" value="F:quinone reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0000270"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C2E1P3.01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-0521">NADP</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000438581" description="Dehydrogenase orsE">
        <location>
            <begin position="1"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="43"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="130"/>
            <end position="137"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="180"/>
            <end position="183"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="203"/>
            <end position="206"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="272"/>
            <end position="273"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="292"/>
            <end position="296"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="339"/>
            <end position="340"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="Q9Y7D0"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="19666480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="20174687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="23841751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="6">
        <source>
            <dbReference type="PubMed" id="23892751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="7">
        <source>
            <dbReference type="PubMed" id="19666480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="8">
        <source>
            <dbReference type="PubMed" id="23841751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="9"/>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAA59568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005890"/>
        </source>
    </evidence>
    <sequence length="348" mass="35972" checksum="2A7D7461EC0953A0" modified="2005-04-26" version="1">MATNQAAWLTKAGNDLEVGDAPVPTAGPGEIVVKNAAVAINPLDTHMQDVGVFVQQWPTIFGCDVAGTVHETGPDVERFKKGDRVIGHAINLVTGRPQDGAYALYTVVPANKAAILPDAISFTDGVVAPFAVEAAVCVLSLKEPGVAMPGVSTPALALPYPSLDDPVKPLGKVLVIWGGSSSVGSMTTQIATAAGIQVIAISGAHNFELSKRCGATEVFDHKDPEVVDKVVAAVQKSGQEFVGIFDAVATPDTYTSDLVILEKLGGGHLAAVHPPPAEVPSNVKAGMIFAVNDIATPVWNDFVTPALESGKIQCLPPPTIVGKGLEAINEGLKRCKAGVSATKLVVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AWC7</accession>
    <accession>C8VCE0</accession>
    <name>Q5AWC7_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_07403</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF78449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_680672.1">
        <property type="nucleotide sequence ID" value="XM_675580.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AWC7"/>
    <dbReference type="STRING" id="227321.Q5AWC7"/>
    <dbReference type="ESTHER" id="emeni-q5awc7">
        <property type="family name" value="Bacterial_esterase"/>
    </dbReference>
    <dbReference type="GeneID" id="2869877"/>
    <dbReference type="KEGG" id="ani:ANIA_07403"/>
    <dbReference type="eggNOG" id="ENOG502REH0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038297_1_0_1"/>
    <dbReference type="InParanoid" id="Q5AWC7"/>
    <dbReference type="OMA" id="GNGHMVF"/>
    <dbReference type="OrthoDB" id="9978720at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019433">
        <property type="term" value="P:triglyceride catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd12809">
        <property type="entry name" value="Esterase_713_like-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050228">
        <property type="entry name" value="Carboxylesterase_BioH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43194:SF4">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43194">
        <property type="entry name" value="HYDROLASE ALPHA/BETA FOLD FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="18"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF78449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="318" mass="34780" checksum="56B216144926E188" modified="2005-04-26" version="1">MYVEKLMPTTGVTKPYPIVFIHGQAQTGTNWLNKPDGGEGWASYFLSQGYECYILDQTFRGRSPWFPGNGTVSTYSAELLQQRFTAPQQYNLWPQASLHTQWNGMGVMGDPIFDTYYASTVEFLDSATYQQSTVQAAGAALLDLIGSPVVLLSHSQGGPIGWLIADMRPNLVHSIVSIEPTGPPFQEAVFSNASARPYGLTDIPLTFSPPVTDPANDLVKKIIPSNSSLYSDCVMQASSPSPRQLVNLAHVPVLVVTTESSYHAPYDWCTVQLLQQAGVSAKHLKLADIGIHGNGHMVFMEKNSLQVAATLGQWIERT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="115" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AWY1</accession>
    <accession>C8VD23</accession>
    <name>Q5AWY1_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ANIA_07199</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF78881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_659711.1"/>
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        <property type="interactions" value="386"/>
    </dbReference>
    <dbReference type="GeneID" id="2870152"/>
    <dbReference type="KEGG" id="ani:ANIA_07199"/>
    <dbReference type="eggNOG" id="KOG1196">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_29_2_1"/>
    <dbReference type="InParanoid" id="Q5AWY1"/>
    <dbReference type="OMA" id="DKVMGMT"/>
    <dbReference type="OrthoDB" id="809632at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="entry name" value="PGDH"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041694">
        <property type="entry name" value="ADH_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045010">
        <property type="entry name" value="MDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205:SF19">
        <property type="entry name" value="ENOYL REDUCTASE (ER) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16884">
        <property type="entry name" value="ADH_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidoreductase N-terminal" evidence="4">
        <location>
            <begin position="5"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="3">
        <location>
            <begin position="168"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBF78881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="371" mass="40780" checksum="413346E40583C668" modified="2005-04-26" version="1">MPSSKQWILANKPTDLPTLSGPTPTFKLTSADVPKPSSSQALVKTLMLSNDPAQRTWIVPNADPERLYLPPVQEGSPMSAFALAEVVESGSPNELPVGSLVLCPTNWTEYSVHEIKTLQKIQPIEGLDLGHFLGALGMTAVTAYYGIKEVAGTTKDDTVVVSGAAGATGSMVVQIAKKIIGCKRVIGIAGTDDKCRWVETLGADVCINYKKDSFEQDLIKETEGFVEVYFDNVGGNILDLMLTRMKRHGRIAACADDKQEVISMRLHIRGFIVLDYYHKFSDVIAELTQAWKEGKIVVDESMQTVVEAKFEDIPNVWMKLFEGGNTGKLCTKIVSRRHRVRRGKEKRQVLIIIAATGCLNLWSPINVKSMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AX29</accession>
    <accession>C8VD74</accession>
    <name>Q5AX29_EMENI</name>
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        <recommendedName>
            <fullName evidence="2">alpha-L-rhamnosidase</fullName>
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        <name evidence="8" type="ORF">ANIA_07151</name>
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    <organism evidence="8 9">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing alpha-L-rhamnose residues in alpha-L-rhamnosides.</text>
            <dbReference type="EC" id="3.2.1.40"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.2.1.40" evidence="2"/>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF78974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_664755.1">
        <property type="nucleotide sequence ID" value="XM_659663.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AX29"/>
    <dbReference type="SMR" id="Q5AX29"/>
    <dbReference type="STRING" id="227321.Q5AX29"/>
    <dbReference type="GeneID" id="2870156"/>
    <dbReference type="KEGG" id="ani:ANIA_07151"/>
    <dbReference type="eggNOG" id="ENOG502QXBB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002926_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AX29"/>
    <dbReference type="OMA" id="IWELWNG"/>
    <dbReference type="OrthoDB" id="10036721at2759"/>
    <dbReference type="UniPathway" id="UPA00280"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030596">
        <property type="term" value="F:alpha-L-rhamnosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.420.10">
        <property type="entry name" value="Maltose phosphorylase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016007">
        <property type="entry name" value="Alpha_rhamnosid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035396">
        <property type="entry name" value="Bac_rhamnosid6H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035398">
        <property type="entry name" value="Bac_rhamnosid_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013737">
        <property type="entry name" value="Bac_rhamnosid_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008902">
        <property type="entry name" value="Rhamnosid_concanavalin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33307">
        <property type="entry name" value="ALPHA-RHAMNOSIDASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33307:SF6">
        <property type="entry name" value="ALPHA-RHAMNOSIDASE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05592">
        <property type="entry name" value="Bac_rhamnosid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17389">
        <property type="entry name" value="Bac_rhamnosid6H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17390">
        <property type="entry name" value="Bac_rhamnosid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08531">
        <property type="entry name" value="Bac_rhamnosid_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25788">
        <property type="entry name" value="Ig_Rha78A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010631">
        <property type="entry name" value="A-rhamnsds"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bacterial alpha-L-rhamnosidase N-terminal" evidence="5">
        <location>
            <begin position="143"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-L-rhamnosidase concanavalin-like" evidence="4">
        <location>
            <begin position="322"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-L-rhamnosidase six-hairpin glycosidase" evidence="6">
        <location>
            <begin position="425"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-L-rhamnosidase C-terminal" evidence="7">
        <location>
            <begin position="791"/>
            <end position="864"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBF78974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="905" mass="99982" checksum="B4E9F863D17A5291" modified="2005-04-26" version="1">MSLSISGVTFEHHRSALGIGEPSPRISWRFDGTVSNWTQSAYEIEINRAGQANTFRVNSSDSVLVPWPSDPLQSGEEATVRVRSFGRANQPDAPWSDPVTVEPGLLDEDDWQSAVAIVSDRETEVNATHRPIYFRKDFDVDEEILSARLYITALGVYEAEINGQPVGDHVLAPGWQAYSHRHEYNTYDVTDLLQTGDNTIGVTVGEGWYAGALTWSMTRNIYGDTLGLLSLLSIATADGKTIYVPSDETWQSSTGPIIASEIYNGETYDSTQAIEGWSQPGFDASGWLGTHEVTFDKSVLAAPDAPAVRRVEERRLESVFKSASGKTVLDFGQNLVGWLRVRVKGPRGSTISFVHTEVMENGEVATRPLRNAKATDNLTLSGEEQEWEPSFTFHGFRYVQVTGWPEETELNADSVTAIVINSDMEQTGFFSCSNPLLNKLHENIIWSMRGNFLSIPTDCPQRDERLGWTGDIHAFARTANFIYDTSGFLRGWLRDAYSEQLENNCTAFLLPNPVISMLTRADAPPYVIPNVLGPGSPTSIWGDAIVSVPWDLFQTYGDKAMLSEQYAGATAWLDKGILRNEAGLWNRSTFQYADWLDPLAPPDDPGAATTNKYLVSDAYLIHSTELVANISAYLDRPDDAERYAADRADLTRAFQKAWISANGTVANETQTGLTLPLYFKLFERPEHYTDAVSRLVDIIKENEYKVGTGFAGTHLLGHTLSAYNASSTFYNTLLQEDVPGWLFQVLMNGTTTWERWDSMLANGSVNPGEMTSFNHYAVGSVGAWMHENIGGLRPIEPGWRRFAVDVKVGGGLSSAQERFLSPYGSAESSWEVRDGKFMLGVKVPPNSEAVVSLPGAPTRGKKEVIVGSGMHRFEKLTAESRARLEEAKERPLLSSSNDCSLAIAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AXA0</accession>
    <accession>C8VDF7</accession>
    <name>Q5AXA0_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_07080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF79124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_664684.1">
        <property type="nucleotide sequence ID" value="XM_659592.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AXA0"/>
    <dbReference type="GeneID" id="2869983"/>
    <dbReference type="KEGG" id="ani:ANIA_07080"/>
    <dbReference type="HOGENOM" id="CLU_2145829_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AXA0"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF79124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="112" mass="12210" checksum="9AEC97275DD45941" modified="2005-04-26" version="1">MARGSGNGSNGAAGAKGKGSKENDKTMEKDTLAKTNKGRKAGIKQSMSEDYLWPVSLYLHDKLDAESLTALRANHDKVSKSDTNGDLLVRVLYLLEQKSMADRATLLEGQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AXC3</accession>
    <accession>C8VB46</accession>
    <name>Q5AXC3_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_07057</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF79173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_664661.1">
        <property type="nucleotide sequence ID" value="XM_659569.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AXC3"/>
    <dbReference type="GeneID" id="2870199"/>
    <dbReference type="KEGG" id="ani:ANIA_07057"/>
    <dbReference type="HOGENOM" id="CLU_1627017_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AXC3"/>
    <dbReference type="OMA" id="NELGYFT"/>
    <dbReference type="OrthoDB" id="6132182at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF79173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="163" mass="18466" checksum="A8CAA95A7051B547" modified="2005-04-26" version="1">MRTTKTTADTINGLLDKTASSTLRRLDLGFLTIGFLGYVFKYLDQINISNAYVSGMQDNLKLYSNELGYFTTYFNISTTNQVLWNVFTCCLSTVTNEKQGVCTIFVALIAFVLLPRYFGYPPDMERLDGHGPPHLVNYEVFVTFIRPYEAGTLPILRTKTSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="112" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AY23</accession>
    <accession>C8V2E7</accession>
    <name>Q5AY23_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ANIA_06807</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF71501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_664411.1">
        <property type="nucleotide sequence ID" value="XM_659319.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AY23"/>
    <dbReference type="GeneID" id="2870664"/>
    <dbReference type="KEGG" id="ani:ANIA_06807"/>
    <dbReference type="eggNOG" id="ENOG502RF04">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_303264_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AY23"/>
    <dbReference type="OrthoDB" id="2151789at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026841">
        <property type="entry name" value="Aur1/Ipt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF22">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14378">
        <property type="entry name" value="PAP2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010172054" description="FAD-binding PCMH-type domain-containing protein" evidence="6">
        <location>
            <begin position="21"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="910"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="941"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="7">
        <location>
            <begin position="65"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBF71501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="982" mass="108759" checksum="65BE5CD9971169F8" modified="2005-04-26" version="1">MFRQVSSACALLGLILGASATKATGPGPEACGNLTQLLGSKTVVSNTLSINYIDSTQSYYNTEQSKYKPSCIVYPVSTDDVSIAIKAIRRSDSRFAIKAGGHNPNDFYSSVDKGVLIDLSRMAERFYDEESTLATYQPGGDFGDIYDYFSQWNRTVVGARLAGVGTGLALSGGLSYLSSQYGLACDSFRELEVVLPSGEIVTASESTNPDLFYGLRGGGGNAYGVVTKYTVQSYPANTFYAGNIIYLFQQNTAVLDAITNFIQYNDDPKAAIIGTYEKLPTPGFEHNLDEAIIMFLVYDGPDAGDVFKNFTDIPHLANTLKQTDYNGVVNLPIPGSAELIKGRNTFRVSVHSGDEKGKESLNKLYEKWVAWGNENKGKYLLTSMDIQPIPRSLTDASNSNFGGNAMQMPDGPWFWVNFLLTASSLLSEEELEEANQSYKEMVESVPPTEGLPLFLNDASHDQDPLTTFAGYQKLKEIKAKYDPDGFFKTAVSLSRFPTCDTLWTAYSVTMTSQRTMSLYRTLLYLLSLSAGSRAIEQDELQDFGRYSSDVSRILLTKTVSYTGPESAPIPTTYGNLVDTSQRIRSNNHSDRTDAFSGPPQRKLSCPPQRKQCGDTCIPSTQDCCAASEHCLPGDYCYRHSGSVRCCPEGLACFQISGDVCFQQTVVWYEEIHIIDLNEEEIITSWDIVESVYRTSSRITITASYPSEGRASFTSLSEGIVEAAATPVTLALDEIPTRTVALGAHTTEAMLSDPWSGVHGSLIWGSPSSSHTWLELISDIEFTPVPLEDENGRKEPHEPKRRVYGRVVIRTPNSSRFANHIHSRIVQNFPFLVELFYWVLNYAFYSCTKAISHALSPAGTDVVQLAQDHGIAILDLEHRSIFSIFFPIGESDFQAYFPNGHPGWMTFNRTYSLVHIPGTVVFLSWWYWAAPDHERFAIARRTMTLGNFVAFVVFCFFPCMPPCLLPESFNFHNTVRQGNAESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AYD3</accession>
    <accession>C8V1N2</accession>
    <name>Q5AYD3_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">SUN domain protein (Eurofung)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">ANIA_06697</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SUN family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF71268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_664301.1">
        <property type="nucleotide sequence ID" value="XM_659209.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AYD3"/>
    <dbReference type="FunCoup" id="Q5AYD3">
        <property type="interactions" value="56"/>
    </dbReference>
    <dbReference type="GeneID" id="2870484"/>
    <dbReference type="KEGG" id="ani:ANIA_06697"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN6697"/>
    <dbReference type="eggNOG" id="ENOG502QPVV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033459_1_0_1"/>
    <dbReference type="InParanoid" id="Q5AYD3"/>
    <dbReference type="OMA" id="CSYACQS"/>
    <dbReference type="OrthoDB" id="5339822at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051526">
        <property type="entry name" value="Beta-Glucosidase_SUN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005556">
        <property type="entry name" value="SUN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31316">
        <property type="entry name" value="BETA-GLUCOSIDASE-LIKE PROTEIN NCA3, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31316:SF0">
        <property type="entry name" value="SECRETED BETA-GLUCOSIDASE SIM1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03856">
        <property type="entry name" value="SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0134">Cell wall</keyword>
    <keyword evidence="9" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="107"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="107"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CBF71268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="410" mass="42931" checksum="CD080FBCB1FD4A5C" modified="2005-04-26" version="1">MKYSFALTLATAGSMAAAAQHQHGHHHQHSKREVVTVDGPTVVKYMLDNQLISAEKVCEGITDGTLAWANGQPPSDPCQASSTTSTEAYTPTATAAKFIETEASSSTATSTSTTVSVPSSTTSQPAASSSSASTATGLDAPFPDGELDCSTFPSDYGAVPLDYLGLDGWSGIQYVTLVGEIISDIITAVTGDSCTSGAMCSYACPPGYQKSQWPSTQGSTGQSVGGLQCKFGKLYLTNPDLSDKLCIKGVGGVKAKNTLSDHVAVCRTDYPGTESETIPISLNSGETKEVTCPDGATYYKWEGKTTSAQYYVNPAGTSQEEGCQWGDGSKPIGNWAPINLGVGENNGKWLSIFQNSPTTTEKLDFNIKIQGDNLSGSCKYEDGSFISDTGSNDSGCTVQVMSGDATFVFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AZG5</accession>
    <accession>C8V175</accession>
    <name>Q5AZG5_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ANIA_06315</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF69719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_663919.1">
        <property type="nucleotide sequence ID" value="XM_658827.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AZG5"/>
    <dbReference type="GeneID" id="2871221"/>
    <dbReference type="KEGG" id="ani:ANIA_06315"/>
    <dbReference type="eggNOG" id="ENOG502SJSN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023254_3_0_1"/>
    <dbReference type="InParanoid" id="Q5AZG5"/>
    <dbReference type="OMA" id="IFPVEME"/>
    <dbReference type="OrthoDB" id="4158087at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540">
        <property type="entry name" value="TRANSCRIPTION FACTOR (ACR-2), PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540:SF9">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF69719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="432" mass="48201" checksum="651CA9CAF9BCA22C" modified="2005-04-26" version="1">MGFEFVNNNTAIDSAARKRIRTHAAAGKNANRTLTRPSKAVALRRNVAVPFRTPDTIRRLQRDSKAGAEIERPVTDGLQFLIPVPARSQGLVRQVRETTQGMYHIARTYRIVQDRLMSEEEATSDMTIAILVAMSQYERLQGQYARGYVHVRGMRRMIELRGSIKQFDSDCRGVIQKVLRADLEYALQLGSATLFGFEGIRFLRECKDICLDHGKEEKLVANPEVNSFLQAGLRLSLWSAFSDMRRLADLLNDAGAGYRRKLGADEFHNTILLLGYSLLYISPLDVSTGPGACSMLGISPLEEVVHLGLVAFLVTFLRGLNQRIPENPLLSYRLRLAIEKLLSSVGGGEESKIIKRVLVWALFVGAVVVFKPSDDEWLIPTTNTAMNALGLSSWKDVKEALAGFPWVDAIHDRTGTVLCTTQKFLSFSTQID</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AZM1</accession>
    <accession>C8V1I4</accession>
    <name>Q5AZM1_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_06259</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF69836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_663863.1">
        <property type="nucleotide sequence ID" value="XM_658771.1"/>
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    <dbReference type="AlphaFoldDB" id="Q5AZM1"/>
    <dbReference type="GeneID" id="2871162"/>
    <dbReference type="KEGG" id="ani:ANIA_06259"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN6259"/>
    <dbReference type="eggNOG" id="ENOG502SS0A">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_093227_0_0_1"/>
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    <dbReference type="OrthoDB" id="4749694at2759"/>
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        <property type="component" value="Chromosome I"/>
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    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
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            <end position="49"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF69836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="187" mass="20221" checksum="E485CABBC473CE83" modified="2005-04-26" version="1">MPPSNATQNSQPGKLASPVKHYHERRSSFAVGIWILSILVLGLAAAVVAKAPASPLRSSASYNVAVASLQFFLFFLAGSKPVSTTDARPPKAGTITLVISTLIWAAAFPIMFIFASEDDRYAVVDFDKRVLALDIGTGVVSGLENITLACGAFGASIFLCIIFQWYYTAQLYRGHFTRDHIEAAYND</sequence>
</entry>
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    <accession>Q5B0C6</accession>
    <accession>C8V342</accession>
    <name>Q5B0C6_EMENI</name>
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        <submittedName>
            <fullName evidence="4">Actin cytoskeleton protein (VIP1), putative (AFU_orthologue AFUA_2G10030)</fullName>
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        <name evidence="4" type="ORF">ANIA_06004</name>
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        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF70379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_663608.1">
        <property type="nucleotide sequence ID" value="XM_658516.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B0C6"/>
    <dbReference type="STRING" id="227321.Q5B0C6"/>
    <dbReference type="GeneID" id="2871044"/>
    <dbReference type="KEGG" id="ani:ANIA_06004"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN6004"/>
    <dbReference type="eggNOG" id="ENOG502S19D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074138_0_0_1"/>
    <dbReference type="InParanoid" id="Q5B0C6"/>
    <dbReference type="OMA" id="TQEMKPR"/>
    <dbReference type="OrthoDB" id="7763451at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
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    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32343:SF10">
        <property type="entry name" value="RNA-BINDING REGION RNP-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32343">
        <property type="entry name" value="SERINE/ARGININE-RICH SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="5"/>
            <end position="82"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="90"/>
            <end position="110"/>
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    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="221"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="221"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="255"/>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBF70379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="270" mass="29044" checksum="24ABFD763DBADE51" modified="2005-04-26" version="1">MSDRTTVHVSNIDPSTSEKEVQDFFSFCGKIVSISVTPTSGEPGSLKSATVTFEKDAAAKTALLLDQTQLGPSVVTVKAAQTLDEIAGEHSATAAEAKDENQNDLEQEDKPRSRIIAEYLAHGYTISDQAIQKAIAIDKKHGFTSRFTSVLSNFDKKTGASERAKGLDESYKISDKAANSWRGLHSYFEKAINTPSGRKLRDFYSQTDKQVRDIHAEARRLADLKAGKTEEKKAEGESSSPATESNPAPAPAPGVEPEAAQAAPATTEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="73" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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        <name evidence="2" type="ORF">ANIA_05848</name>
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    <organism evidence="2 3">
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        <name type="synonym">Aspergillus nidulans</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF70716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_663452.1">
        <property type="nucleotide sequence ID" value="XM_658360.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B0T2"/>
    <dbReference type="STRING" id="227321.Q5B0T2"/>
    <dbReference type="GeneID" id="2871168"/>
    <dbReference type="KEGG" id="ani:ANIA_05848"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN5848"/>
    <dbReference type="eggNOG" id="ENOG502S9CJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014758_0_0_1"/>
    <dbReference type="InParanoid" id="Q5B0T2"/>
    <dbReference type="OMA" id="CRPETSF"/>
    <dbReference type="OrthoDB" id="5407653at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="410"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="210"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF70716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="582" mass="65650" checksum="53FA5E9BE2CF4264" modified="2005-04-26" version="1">MFGWSSAIGLPAILSDPDRERSPPPPLNSLDFPIYRLPAVPDEPSEDSLRNLQAVLASIRRPQDITTDKFRDLNLKLETDVPLSSIVRHDGAKTAPPLPWELDSPKPSLGSPLPADGTPIFLENGNPYPTRDKYELLENELLLDNDDAFREVARLEPRAGRERVRVTQTRKFWTALERMSQYWDDSMDQYYDRAKSPEPSEKKADDAEAAGDTETTAETTPMEIDPPTNTSTQDKAEPELVKKYKGRRIAAGQAMPEDIRDETIRALTEMAAWPFGCQASLPMNPPKLLLGTLLFPVRQTFQATRSPKDRQLARNGILEGPVFVAQCRPETVFRAPGETHGYGLGDTCDLVREVGAMLLAAQERAREGAIEVRPGEGKWWTTKPRWGGAPNDAIGDSVRVTNEQEREAAALTGRARSGSRPQPPGLRRPGLRRAMSSSDKWKIIQPGPSLWDKRMRYIQIGRDRECPFDDIYMLSSINHHLSILHLRIHRRYLDIITTGRSTVPPTSNDESHPWHILKLRRTRWYDLFDAQDRVDVFRGIWTIFHVMLRAPRPPEAMPPASLPPITPVDPAVVYRSLPLESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="115" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B163</accession>
    <accession>C8VFM3</accession>
    <name>Q5B163_EMENI</name>
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        <submittedName>
            <fullName evidence="10">Importin beta-3 subunit, putative (AFU_orthologue AFUA_1G06790)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ANIA_05717</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF81343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_663321.1">
        <property type="nucleotide sequence ID" value="XM_658229.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B163"/>
    <dbReference type="FunCoup" id="Q5B163">
        <property type="interactions" value="1079"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5B163"/>
    <dbReference type="GeneID" id="2872010"/>
    <dbReference type="KEGG" id="ani:ANIA_05717"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN5717"/>
    <dbReference type="eggNOG" id="KOG2171">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003794_0_1_1"/>
    <dbReference type="InParanoid" id="Q5B163"/>
    <dbReference type="OMA" id="PKRFVQE"/>
    <dbReference type="OrthoDB" id="543373at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061608">
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        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008139">
        <property type="term" value="F:nuclear localization sequence binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007088">
        <property type="term" value="P:regulation of mitotic nuclear division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060188">
        <property type="term" value="P:regulation of protein desumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000201">
        <property type="entry name" value="Importin beta-3 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058584">
        <property type="entry name" value="IMB1_TNPO1-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040122">
        <property type="entry name" value="Importin_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041653">
        <property type="entry name" value="Importin_rep_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040928">
        <property type="entry name" value="Importin_rep_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041389">
        <property type="entry name" value="Importin_rep_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057672">
        <property type="entry name" value="TPR_IPO4/5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10527">
        <property type="entry name" value="IMPORTIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13513">
        <property type="entry name" value="HEAT_EZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18808">
        <property type="entry name" value="Importin_rep_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18816">
        <property type="entry name" value="Importin_rep_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18829">
        <property type="entry name" value="Importin_rep_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25574">
        <property type="entry name" value="TPR_IMB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25780">
        <property type="entry name" value="TPR_IPO5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="9">
        <location>
            <begin position="30"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="813"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="821"/>
            <end position="833"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBF81343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="1095" mass="121167" checksum="B73C2EAF8EE83F57" modified="2005-04-26" version="1">MSLLPPEVHAALSQLLRALSTPDNNIRSQAEEQLNNDWIQNRPDVLLMGLAEQLEGAEETGTRSFSAVLFRRIATKTRKDPVTNEAKELFSTLAREQRLVIRQKLVTCLTTESANDVRRKIGDAVAEIARQYTDNGDQWPELLGILFQASQSPDAGLREASFRIFSTTPSVIEKPHEDAVIGVFGKGFRDDVVAVRIAAMEAFASFFRSLPKKSQPKFFGLMPEMLNVLPPLKESSESDELSSAFLALIELAEICPKMFKGLFNNLVKFSVSVVANKELSDQVRQNALELMATFADYAPATCKKDPDFTTQMVTQCLSLMTDIGEDDDDASEWNASEDLDLEESDLNHVAGEQCMDRLANKLGGQVVLPVTFEWIPKLMSSAAWRDRHAALMAISAISEGCRDLMVGELDQVLRIVVPALQDPHPRVRYAGCNALGQMSTDFAGTMQEKYHQVVLSNIIPVLSSAEPRVQAHAAAALVNFCEEAERNILEPYLADLLRNLLQLLRSPKRYVQEQALSTIATIADSAENAFEEYYDTLMPLLFNVLKQEQSKEYRLLRAKAMECATLIALAVGKNKMGQDALDLVQLLGNIQQSIVDADDPQSQYLLHCWGRMCRVLGQDFVPYLPGVMPPLLAVAAAKADIQLLDDEDQIDQVEQDEGWELVPLKGKIIGIKTSALEDKNTAIELITIYAQILEAAFEPYVLETMDKIAVPGLAFFFHDPVRVSSAKLIPQLLNSYKKAHGIQSAGFAGMWVKVAEKIIEVLSAEPTVDTLAEMYQCFYESVEVVGRNSLGPQHLQAFIQSAKSTLEDYQSRVKARAEERAEADDGEEENPDYEYAIEDDQNLLSDMNKAFHTIFKNQGTSFLPAWEQLMPFYDAFITSQDPTQRQWALCIMDDVLEFCGPESWRYKDHIIQPLVAGLRDSNAANRQAAAYGVGVAAQKGGEPWSEFVAACLPSLFQVTQFAQSRTEEHVFATENASASIAKILHFNSSKVQNAAEIAANWISTLPITYDEEAAPYAYSFLAQLIDQQNPAVMSNAGQVFGYIVQALDAETLQGQTAGRVANSAKALVQATGLNAEQILAGVSPENQAAVRSYFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B1G0</accession>
    <accession>C8VFX8</accession>
    <name>Q5B1G0_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA polymerase iota, putative (AFU_orthologue AFUA_4G11140)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_05620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF81536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_663224.1">
        <property type="nucleotide sequence ID" value="XM_658132.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B1G0"/>
    <dbReference type="STRING" id="227321.Q5B1G0"/>
    <dbReference type="GeneID" id="2871907"/>
    <dbReference type="KEGG" id="ani:ANIA_05620"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN5620"/>
    <dbReference type="eggNOG" id="KOG2095">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022440_0_0_1"/>
    <dbReference type="InParanoid" id="Q5B1G0"/>
    <dbReference type="OMA" id="MFKRQDE"/>
    <dbReference type="OrthoDB" id="447129at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070987">
        <property type="term" value="P:error-free translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019985">
        <property type="term" value="P:translesion synthesis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd01703">
        <property type="entry name" value="PolY_Pol_iota"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1170.60:FF:000006">
        <property type="entry name" value="DNA polymerase iota"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000067">
        <property type="entry name" value="DNA polymerase iota, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.100:FF:000019">
        <property type="entry name" value="Putative DNA polymerase iota"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.100">
        <property type="entry name" value="DNA polymerase, Y-family, little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036775">
        <property type="entry name" value="DNA_pol_Y-fam_lit_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017961">
        <property type="entry name" value="DNA_pol_Y-fam_little_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003583">
        <property type="entry name" value="Hlx-hairpin-Hlx_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46404">
        <property type="entry name" value="DNA POLYMERASE IOTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46404:SF1">
        <property type="entry name" value="DNA POLYMERASE IOTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00817">
        <property type="entry name" value="IMS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11799">
        <property type="entry name" value="IMS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00278">
        <property type="entry name" value="HhH1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UmuC" evidence="1">
        <location>
            <begin position="13"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF81536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="573" mass="64174" checksum="1BAD9586E37A643B" modified="2005-04-26" version="1">MAAVPLRNDERIILHFDYDCFYASVFEAEQPILKTLPLAVQQKQIVVTCNYEARRRGLRKLQLIKEAKQICPDVVIILGEDLTKFRDASKDLYLFFRRSIWGERVERLGFDEIFMDVTDMITYNAGLLNPNDLTHSFFHLDSRDPTVGFAFDATAVYGRTYPNDRSGKPLSEADTQLHLRLLLASHFAGYLRSQLENQKGYTATAGISTSKLLAKVVGSAHKPNNQTTLLPPYSSTGDCESNVLRFLDSREIRAIPGIGSKLSRKLISHITASDQSAVENKVTIRDVRAFPGMGPSLLERILGGPGAPRDIGVKIWGLLHGVDGTQVGEARDTPTQISIENSYGHLDTFEAVRKEMLSLAASLIRRMRMDLTERYSDAEGSTSLGPRLREETKARWLARPRTFRLSTIPRSTQGSDHTYSRRSHSASLPQYVFNLDEPIDALAERVVRELATPMFRKLHRERTGWNLRVLNLAVTNMAEIAGDGKHNDGRNISKMFQRQEAEPQDTLPASERTWTQSELPVLPSTLTVASEALWESDGEEESMPSVQCTTCGASIPHFALAAHKVYHSTSENN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="100" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B1I9</accession>
    <accession>C8VG14</accession>
    <name>Q5B1I9_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Aminotransferase, classes I and II, putative (AFU_orthologue AFUA_4G11460)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ANIA_05591</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF81603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_663195.1">
        <property type="nucleotide sequence ID" value="XM_658103.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B1I9"/>
    <dbReference type="STRING" id="227321.Q5B1I9"/>
    <dbReference type="GeneID" id="2871882"/>
    <dbReference type="KEGG" id="ani:ANIA_05591"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN5591"/>
    <dbReference type="eggNOG" id="KOG0257">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034385_1_0_1"/>
    <dbReference type="InParanoid" id="Q5B1I9"/>
    <dbReference type="OMA" id="KNWRYPG"/>
    <dbReference type="OrthoDB" id="2108at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050596">
        <property type="entry name" value="AspAT/PAT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46383">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46383:SF1">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="6">
        <location>
            <begin position="104"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBF81603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="481" mass="53753" checksum="D62549C9D4563464" modified="2005-04-26" version="1">MSFSGRRVSILRPSNRRFSVGKELSNNELQSETHRQFRTAHEGHRPHAGLDASRASTGVVWCTERASEHGFLEDPSGWANLGQGAPEADDEIEGSFPRPETIPITSAAREYGPTAGIKPLRAAVARLYNEHYRQGKESQYTWENVCIVPGGRAGLIRIAAILGNSYLSFPIPDYSAYSEMLSLFKNIAPIPMPLAQEDHYHIHPDKIAEEIARGTSVILTSNPRNPTGHFISGDELAHIQDICRDRATLILDEFYGGYNYTTDCDGTTISGAANVVDVNKDDVLLIDGLTKRFRLPGWRIAWVVGPKEFIDALGSAGSYLDGGANVPFQEAAIPMLEPSLVHQEMKALQTHFREKRDFVLKRLREIGFRIQDVPQATFYIWLDLTSLDPPLPKEANISDGLNFFNALLSEKVIVVPGIFFDLNPAKRRDLFDSPCHHFVRLSYGPKMEVLKMGLDGIERVIRRARGEHYEPTAMDEQAIED</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="99" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B1V1</accession>
    <accession>C8VGD9</accession>
    <name>Q5B1V1_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Mismatch-specific thymine-DNA glycosylase, putative (AFU_orthologue AFUA_6G13340)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ANIA_05479</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF81831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_663083.1">
        <property type="nucleotide sequence ID" value="XM_657991.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B1V1"/>
    <dbReference type="STRING" id="227321.Q5B1V1"/>
    <dbReference type="GeneID" id="2871766"/>
    <dbReference type="KEGG" id="ani:ANIA_05479"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN5479"/>
    <dbReference type="eggNOG" id="KOG4120">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042829_1_1_1"/>
    <dbReference type="InParanoid" id="Q5B1V1"/>
    <dbReference type="OMA" id="MCVVGKS"/>
    <dbReference type="OrthoDB" id="565731at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008263">
        <property type="term" value="F:pyrimidine-specific mismatch base pair DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004844">
        <property type="term" value="F:uracil DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd10028">
        <property type="entry name" value="UDG-F2_TDG_MUG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.470.10:FF:000010">
        <property type="entry name" value="G/U mismatch-specific DNA glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="entry name" value="Uracil-DNA glycosylase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015637">
        <property type="entry name" value="MUG/TDG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12159">
        <property type="entry name" value="G/T AND G/U MISMATCH-SPECIFIC DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12159:SF9">
        <property type="entry name" value="G_T MISMATCH-SPECIFIC THYMINE DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00986">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00987">
        <property type="entry name" value="UreE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="Uracil-DNA glycosylase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uracil-DNA glycosylase-like" evidence="5">
        <location>
            <begin position="184"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="57"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="369"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="92"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="102"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBF81831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="389" mass="42212" checksum="8D41E1DC93B8B8D8" modified="2005-04-26" version="1">MARSSSIAQTQASSKGNDSGSISYENDVPVNQVTSFHGVLNKYIHVSETKTETVGFNCSTQESKRQLYTADDPDADARTTPKRRRGVHAQPACQTQNVSAMTTGITATRRITRSQSRSSTPASSSASPSLTVPSTSSRSAPESQSPTPSARIPRHSRSRSRGSSTPRKNTSSPSSLPASTSLLRDTIPPNLTLLLVGVNPGIMTGTTGFAYAHPSNLFWKLLHSSGITSIRHPPSDTYRLPELYNVGNTNIVERPTRDASMLSKAEMDAGVPVLEAKVAAKRPAAVCLVGKSIWEAVWRARKGRPIRKEEFRYGWQDEEENMGRSEEWEGAPVFVATTTSGLAAGMSYPEKQAIWNELGRWVVNERANSQGHAQARVQTEAEAEAEDQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B221</accession>
    <accession>C8VGL4</accession>
    <name>Q5B221_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_05409</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF81958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_663013.1">
        <property type="nucleotide sequence ID" value="XM_657921.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B221"/>
    <dbReference type="STRING" id="227321.Q5B221"/>
    <dbReference type="GeneID" id="2871704"/>
    <dbReference type="KEGG" id="ani:ANIA_05409"/>
    <dbReference type="eggNOG" id="ENOG502S4U3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_685169_0_0_1"/>
    <dbReference type="InParanoid" id="Q5B221"/>
    <dbReference type="OMA" id="IDFPQWT"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="CDD" id="cd08946">
        <property type="entry name" value="SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051783">
        <property type="entry name" value="NAD(P)-dependent_oxidoreduct"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079:SF6">
        <property type="entry name" value="NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079">
        <property type="entry name" value="PROTEIN YEEZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="2">
        <location>
            <begin position="75"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF81958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="415" mass="46006" checksum="BCFA2B761B0B6FCC" modified="2005-04-26" version="1">MYHCSYPTTQTASRLAMAVRDDRTRSLSTISQRSTACQQPFPEELHSRFGNGGSSLWGYNRFCSMIHSSTMPSTVLVTGANGYIGNAVARAFSRAGWITYGLVRSESAVRSLQLEEILPVLGQIDDIDSHSAILHQLPKTLDAIVSTTENLDDYITHHKNTIQLLRTLSLASGRHGVRPLVIVSSGCKDYGIGPHYHGDRDLKPHTEESPLNPPDPVSKRANMSLEIFKNSDAFAPVLVRPTNVYGRSASYYRGFFEVAVLAKKQSLPLQIPVSPASICHALHVDDCGDAYVALAAHPRRAEIEGGIFNISGREYETVNQIARALVAEYDLAGVEYVNSEDVGPVGKAWPPMLIDFPQWTGSNKIREITGWRDMRPLFSDTVGLYRRAYEAAVETGHENIAKMVKREKMLPRQHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="115" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B296</accession>
    <accession>C8VGU3</accession>
    <name>Q5B296_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transposase Tan1-Aspergillus niger (ANG_orthologue An07g09460)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ANIA_05334</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF82083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_662938.1">
        <property type="nucleotide sequence ID" value="XM_657846.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B296"/>
    <dbReference type="GeneID" id="2871624"/>
    <dbReference type="KEGG" id="ani:ANIA_05334"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN5334"/>
    <dbReference type="eggNOG" id="KOG3105">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013929_4_0_1"/>
    <dbReference type="InParanoid" id="Q5B296"/>
    <dbReference type="OMA" id="RILLATX"/>
    <dbReference type="OrthoDB" id="4457643at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF62">
        <property type="entry name" value="HTH CENPB-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05225">
        <property type="entry name" value="HTH_psq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00674">
        <property type="entry name" value="CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="4">
        <location>
            <begin position="60"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBF82083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="531" mass="59696" checksum="267443BEC4C43E1A" modified="2005-04-26" version="1">MPRVRVSSSQNCHEKEGRLLLAVQAIKKKEITSIREAARRFNVPESTLRTRLRGTTNRAESRANGHKLTEIEEEVLKQWILSLDLRGAAPTKAHVREMANILLAKRGSTPIQTVGQKWVYNYTQRHPELESRLSRQYDCQRAKQENPKVIQAWFNTVRATIEQYGILPDDIYNFDETGFAMGLCAHQKVITKSESCGRRPVLQPGNREWVTAIESISASGWALPPTLIFKGKQYNQACLRWLQKQFIPSTEHRTRGRYQLLVLDGHGSHLTPEFDQICTDHNIIPLCMPAHSSHLLQPLDIGCFAVLKRSYASLVDQKMRLGISHIDKLDFLAAYPQARISTFKLDTIRNSFRAAGLVPLNPEPVLSKLSIQARTPTPPGSRGSQASTFCPHTPANVDELLKQASLLRDFLKQRSKSPPSPSHNALNQLIKGCQIAMQKGILLEQENRALRAENAIQRRKRARTHRWITHDNGLSVQEATELEEAHNASFQAIPGPCGPPAEGAQTPKARALPTCSTCHRIGHRRNACPNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="118" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B2E3</accession>
    <accession>C8VGZ5</accession>
    <name>Q5B2E3_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ANIA_05287</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF82167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_662891.1">
        <property type="nucleotide sequence ID" value="XM_657799.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B2E3"/>
    <dbReference type="STRING" id="227321.Q5B2E3"/>
    <dbReference type="GeneID" id="2871576"/>
    <dbReference type="KEGG" id="ani:ANIA_05287"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN5287"/>
    <dbReference type="eggNOG" id="KOG1469">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018204_1_2_1"/>
    <dbReference type="InParanoid" id="Q5B2E3"/>
    <dbReference type="OMA" id="QYNPEMQ"/>
    <dbReference type="OrthoDB" id="434771at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050741">
        <property type="entry name" value="Acyl-CoA_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083:SF11">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE_OXIDASE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083">
        <property type="entry name" value="MEDIUM-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="8">
        <location>
            <begin position="48"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="7">
        <location>
            <begin position="164"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBF82167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="326" mass="36822" checksum="E23E55BD6B696F37" modified="2005-04-26" version="1">MGKVYWAGQTMNCHAPETGNIELLAKYCNEQQKEQWLKPLLRGEFASAYSMTEPDVASSDATKIAISIRREGDEYMINGRKLFATKWNPEVKLYILMGCTDPNNPNPRRRHSMLLIPSDTPGFRMRQNLSIMGHDCAPESHGEYVYDNVRIPVSNVVLGEGGAFEIAQGRLGPGRIHHCMRLIGQAELAFDYALVRATDERKKPRGKLIWQFDSNIERIAQMRLKLDALRLVVFNAADTMDALGNKSGRYVIAQSKILVPIAVAKIVDECMQLYGGRVGRDQLKTAGSVVARHQQYYKVALQLKKQFGLDEELGDDCTWEYIEPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B2Q0</accession>
    <accession>C8VF53</accession>
    <name>Q5B2Q0_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_05180</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF81028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_662784.1">
        <property type="nucleotide sequence ID" value="XM_657692.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B2Q0"/>
    <dbReference type="STRING" id="227321.Q5B2Q0"/>
    <dbReference type="GeneID" id="2871474"/>
    <dbReference type="KEGG" id="ani:ANIA_05180"/>
    <dbReference type="eggNOG" id="ENOG502SICM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005860_0_0_1"/>
    <dbReference type="InParanoid" id="Q5B2Q0"/>
    <dbReference type="OMA" id="MMRWLLG"/>
    <dbReference type="OrthoDB" id="3903581at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="612"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="778"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="612"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="640"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="661"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="679"/>
            <end position="700"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF81028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="881" mass="98965" checksum="6B380DF69B8217A3" modified="2005-04-26" version="1">MALVHSPIPVPPDAERPEIDTETVEELWEDKHNHNDGQKTVDTALGDDTTQRPLSLFERVITTHTPILESLLLQTPTAAILNLSHTSRYLRSFLRSYPTAWKYLSFRLLYPSGTQSPLRIILPGASDPRTPRQSRPYALDQLLMNVVVPFSPCLKSLELDNTAVSGQILIATVLNPRRETLEHVSVRGCKNVSLKYHIIPYLTMFGLQYDVSMENSIGSSPATQRLALKSLYTYRCRHHRRRPYLSSSLTRKDSDSEPTHELVNLCHKLGIWTDTAWCSTPAGRCFRRRGYVAMRAPQGSPEVWVVFDRLWRSKNWIGPIEGSSSRPTQRDGKLWEHDETGCFGEALGTGEKRDIGEGKMLPAHLRRSHRRFVENIRCDNCCELVSERCEQCSILMHCVGCRKTLCASCAYERPYLHAQASKNTTTGSFWWAPGATTSPCSMHDPAENAEDPAAQPNTPLSYPALKFHWCCTEPIFSGGGGISIGTPNRDVDQVRAAPLPRGEGWEDLEYSAQEWSKSFPKYAYGDPHKPDYSLEAGHIAMMKWLLGPPDRQPSACPRNLCKECYDTPQWKVHCKTCSKPLCIEHDLRGLRLRICGYRDLTLEKLAIQNRTETTAVSQTDEPAPPLQNTATTGFDLPYRTQRTVDSTTSSFTEDHPADVNPQPSTTSSSAVPPLRRSRSISASNSNRSRSSSPSIYSDSPVEQQTPKWQGCQSFFCPQYRPIGDQRSRCASVLRECTSCSVFVCQDCVSRHPPCKCSYCETNYLCPNCAKLRDRDGTCRRAEEEKARREQKLQRDMQTLERILETKLANEVAEYAGQFFGFVDSSNSTGLPNSVLAASDEEVEVEVDVEAPHHPSASSPHHVDVHESLQLLLIQTLLGSNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B3A5</accession>
    <accession>C8V8Z6</accession>
    <name>Q5B3A5_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Fructosyl amino acid oxidasesarcosine oxidase, putative (AFU_orthologue AFUA_3G10130)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ANIA_04975</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MSOX/MTOX family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF76360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_662579.1">
        <property type="nucleotide sequence ID" value="XM_657487.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B3A5"/>
    <dbReference type="STRING" id="227321.Q5B3A5"/>
    <dbReference type="GeneID" id="2872774"/>
    <dbReference type="KEGG" id="ani:ANIA_04975"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN4975"/>
    <dbReference type="eggNOG" id="KOG2820">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007884_0_1_1"/>
    <dbReference type="InParanoid" id="Q5B3A5"/>
    <dbReference type="OMA" id="WRKQGDD"/>
    <dbReference type="OrthoDB" id="2219495at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050031">
        <property type="term" value="F:L-pipecolate oxidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004657">
        <property type="term" value="F:proline dehydrogenase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008115">
        <property type="term" value="F:sarcosine oxidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045170">
        <property type="entry name" value="MTOX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961">
        <property type="entry name" value="PEROXISOMAL SARCOSINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961:SF46">
        <property type="entry name" value="PEROXISOMAL SARCOSINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="6">
        <location>
            <begin position="7"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBF76360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="441" mass="48250" checksum="A7B05826B72B46B6" modified="2005-04-26" version="1">MSLPDNILIVGGGVFGLSTALSLSKRHPNSKVTLLEASPTIPNPHGSSVDSSRIIRADYSNPTYAKLASEAVDLWRTTEWGHEGRYTQNGLLLVYPDGNSTAKDYTTKSYHNVKQLGENAQFLPTKADVLKAAPAYGETLQVAGGYVNWSSGWADAEAGVRFAKQKLDKEGKVRFVHGEVSRLLFSPIDNRTVTGVVLKDFKNTTMTADLVILATGAWTAGLVDLRGRAVSTGQAIAYMRISDEEQRRLEHMPTILNFATGIFIIPPRNNILKIARHAYGYHNPKAVPVPGATPTGETMHVSLPEKGVPIPLEGETAFRTALKQLLPSFADRPFLNTRICWYTDTPRGDFIITHHPSHPHLVLATGGSGHAYKFFPLIGEKVVDALEGKLAPELRALWDWPEAVDEAHFDGTEDGSRSGDKRLLLLDELAKGQKAKRESAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B3D2</accession>
    <accession>C8V924</accession>
    <name>Q5B3D2_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dolichol-phosphate mannosyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ANIA_04948</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF76416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_662552.1">
        <property type="nucleotide sequence ID" value="XM_657460.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B3D2"/>
    <dbReference type="ESTHER" id="emeni-q5b3d2">
        <property type="family name" value="Fusarinine_C_esterase_sidJ"/>
    </dbReference>
    <dbReference type="GeneID" id="2872747"/>
    <dbReference type="KEGG" id="ani:ANIA_04948"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN4948"/>
    <dbReference type="eggNOG" id="KOG4840">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049633_3_0_1"/>
    <dbReference type="InParanoid" id="Q5B3D2"/>
    <dbReference type="OMA" id="LHYLYSP"/>
    <dbReference type="OrthoDB" id="10034502at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013744">
        <property type="entry name" value="SidJ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31591:SF5">
        <property type="entry name" value="DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31591">
        <property type="entry name" value="UPF0613 PROTEIN PB24D3.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08538">
        <property type="entry name" value="DUF1749"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF76416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="326" mass="36082" checksum="20395FA21A6C6737" modified="2005-04-26" version="1">MALPSYPGILHNYAPRLVAFEFRSSGTLKPHSLLFIGGLTDGLYTVPYVQGLANALEPTEWSLFHLHLSSSYGGWGIGSLDRDVEEIGQCIEYVRNLKQRTTSGAKVVIMGHSTGSQDVLHYLYSANPTPRNPDVDGVHSLTRPAVDGAIVQAPVSDREALLQCAKESPEAREAYEKLVTFAREQPARAICPIELSGLVGLDPVTPVSARRFWSLASPESPEKPSEDDLFSSDLTDERLGETFGRIAERGLLRTTLVALYSGSDEYCPNWVDKEALLERWKRATNARGEKKWDDEISGIIPGASHNVRDEGQAWMIERILSYLNRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="112" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B3F5</accession>
    <accession>C8V9E3</accession>
    <name>Q5B3F5_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glutamate carboxypeptidase Tre2, putative (AFU_orthologue AFUA_3G10650)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ANIA_04925</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M28 family. M28B subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF76468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_662529.1">
        <property type="nucleotide sequence ID" value="XM_657437.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B3F5"/>
    <dbReference type="STRING" id="227321.Q5B3F5"/>
    <dbReference type="GeneID" id="2872719"/>
    <dbReference type="KEGG" id="ani:ANIA_04925"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN4925"/>
    <dbReference type="eggNOG" id="KOG2195">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005688_1_0_1"/>
    <dbReference type="InParanoid" id="Q5B3F5"/>
    <dbReference type="OMA" id="YPRKDGR"/>
    <dbReference type="OrthoDB" id="5841748at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd08022">
        <property type="entry name" value="M28_PSMA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02121">
        <property type="entry name" value="PA_GCPII_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.930.40:FF:000006">
        <property type="entry name" value="Glutamate carboxypeptidase Tre2, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.30.30:FF:000029">
        <property type="entry name" value="Glutamate carboxypeptidase Tre2, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000101">
        <property type="entry name" value="N-acetylated alpha-linked acidic dipeptidase like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.40">
        <property type="entry name" value="Transferrin receptor-like, dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046450">
        <property type="entry name" value="PA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039373">
        <property type="entry name" value="Peptidase_M28B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007365">
        <property type="entry name" value="TFR-like_dimer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036757">
        <property type="entry name" value="TFR-like_dimer_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10404:SF71">
        <property type="entry name" value="CARBOXYPEPTIDASE TRE2, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G10650)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10404">
        <property type="entry name" value="N-ACETYLATED-ALPHA-LINKED ACIDIC DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04253">
        <property type="entry name" value="TFR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52025">
        <property type="entry name" value="PA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47672">
        <property type="entry name" value="Transferrin receptor-like dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="168"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="PA" evidence="4">
        <location>
            <begin position="311"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="6">
        <location>
            <begin position="500"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="domain" description="Transferrin receptor-like dimerisation" evidence="5">
        <location>
            <begin position="755"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBF76468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="884" mass="98730" checksum="BDE93499E38D619F" modified="2005-04-26" version="1">MTKDQKYEYDSLPIPSYEEAIADRPSSSRTHLAADVTDDPAAEGQALLHETRESAARDGPQSRPHGYHPPTVESARNSVDDLGSSPAASERGSLEELRGELNQMDVEDGSQQSSQRSRLRSRLSKPFSNLGRTLSSIHLPLRRFLPNFKFTINLNSARTSFNSNGCIILLRLFGLLLVIAVIYVFVVSDVFNFSSRFMMGQSYSAASVENFVQGHINETNIAEYLRRVTEFPHMAGTEGSYVLAEWIQREFEEAGLETIEMEKYEVYLNYPKEDGRRIAIIDPPDLRWEAILEENDSETPVFHGHSKSGNVTGHLVYANYGSREDFQYLADKGINLNGSIALVRYYGTESDRALKVKAAELAGAAGCIIYSDPSDDGFVRGAAYPKGRFMPADGVQRGAVSQMSYVVGDVLSPGFASTPQMKTRLSLEQTTGMPGIPSLPLAWRDAQRLLQVLEGHGSKVPKKWVGGVPKVKQWWTGDEKSPTVNLMNLQDEVDRQPIYNVIGRIHGMEEPEKKIIVGNHRDSWCLGSADPGSGTAVFLELVRVFGELLTFGWRPLRTIEFASWDAEEYNLIGSTEHVEDSMDNLHGNAYAYINVDVGVSGTDFEASGCPLYERVVMQVLGRISDPVTNETLKDIWEQKNKRFAPLGAGSDYVAFQDLAGISSIDFGFTGEPYPYHSCHENFDWMAKFGDPGFQYHKILGQFWGLLLLQFADNPILPYDVEVYAEHLAGYVIDLENYARSKNVPIDNNASGDSSVNLTPLYNATSKLRADAEQFQQWPKLWHDAVWGAGGFENNIIALQRMSHNFRMAKLDVHLLDNRYGGGIPNRTQFKHVVFGPQLWSGYDAAIFPAIQDSLETRNWTLAQEWVDRIAGIIQNAGDKLLHDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="123" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B4K7</accession>
    <accession>C8V8A6</accession>
    <name>Q5B4K7_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DOD-type homing endonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ANIA_04523</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF77331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_662127.1">
        <property type="nucleotide sequence ID" value="XM_657035.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q5B4K7">
        <property type="interactions" value="1278"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5B4K7"/>
    <dbReference type="GeneID" id="2872315"/>
    <dbReference type="KEGG" id="ani:ANIA_04523"/>
    <dbReference type="eggNOG" id="KOG1795">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000380_3_0_1"/>
    <dbReference type="InParanoid" id="Q5B4K7"/>
    <dbReference type="OMA" id="ANKWNTS"/>
    <dbReference type="OrthoDB" id="1931567at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097157">
        <property type="term" value="F:pre-mRNA intronic binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000386">
        <property type="term" value="F:second spliceosomal transesterification activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030619">
        <property type="term" value="F:U1 snRNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030620">
        <property type="term" value="F:U2 snRNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030623">
        <property type="term" value="F:U5 snRNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000350">
        <property type="term" value="P:generation of catalytic spliceosome for second transesterification step"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000389">
        <property type="term" value="P:mRNA 3'-splice site recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000395">
        <property type="term" value="P:mRNA 5'-splice site recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030908">
        <property type="term" value="P:protein splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000244">
        <property type="term" value="P:spliceosomal tri-snRNP complex assembly"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd08056">
        <property type="entry name" value="MPN_PRP8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13838">
        <property type="entry name" value="RNase_H_like_Prp8_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.80.40:FF:000001">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.230:FF:000001">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1570.40:FF:000001">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="1.20.80.40">
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="3.30.420.230">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.16.10">
        <property type="entry name" value="Hedgehog/Intein (Hint) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.28.10">
        <property type="entry name" value="Homing endonucleases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.40">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8, U5-snRNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036844">
        <property type="entry name" value="Hint_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007868">
        <property type="entry name" value="Hom_end_hint"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027434">
        <property type="entry name" value="Homing_endonucl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004042">
        <property type="entry name" value="Intein_endonuc_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012591">
        <property type="entry name" value="PRO8NT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012592">
        <property type="entry name" value="PROCN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012984">
        <property type="entry name" value="PROCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027652">
        <property type="entry name" value="PRP8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021983">
        <property type="entry name" value="PRP8_domainIV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043173">
        <property type="entry name" value="Prp8_domainIV_fingers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043172">
        <property type="entry name" value="Prp8_domainIV_palm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019581">
        <property type="entry name" value="Prp8_U5-snRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042516">
        <property type="entry name" value="Prp8_U5-snRNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019580">
        <property type="entry name" value="Prp8_U6-snRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019582">
        <property type="entry name" value="RRM_spliceosomal_PrP8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11140">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR PRP8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11140:SF0">
        <property type="entry name" value="PRE-MRNA-PROCESSING-SPLICING FACTOR 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05203">
        <property type="entry name" value="Hom_end_hint"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08082">
        <property type="entry name" value="PRO8NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08083">
        <property type="entry name" value="PROCN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08084">
        <property type="entry name" value="PROCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12134">
        <property type="entry name" value="PRP8_domainIV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10598">
        <property type="entry name" value="RRM_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10597">
        <property type="entry name" value="U5_2-snRNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10596">
        <property type="entry name" value="U6-snRNA_bdg"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51294">
        <property type="entry name" value="Hedgehog/intein (Hint) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55608">
        <property type="entry name" value="Homing endonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50819">
        <property type="entry name" value="INTEIN_ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="DOD-type homing endonuclease" evidence="8">
        <location>
            <begin position="1935"/>
            <end position="2029"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1713"/>
            <end position="1732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1750"/>
            <end position="1799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="18"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1753"/>
            <end position="1762"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBF77331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="2945" mass="339759" checksum="89C8027C2280A850" modified="2005-04-26" version="1">MASLPPPPPPGWGASAPPSMPLAPPPPGYQPPADPNVAKYAQKKTEWLRTQRNRFGEKRKGGFVETQKADMPPEHLRKIVKDIGDVSQKKFTNEKRSYLGALKFMPHAVLKLLENMPMPWESTREVKVLYHVNGCLTLVNETPRVIEPVFHAQWATMWVCMRREKSDRRHFKRMRFPPFDDEEPPLSWSENIEDVEPLEPIQMELDESEDSPVYEWFYDHRPLLDTPHVNGPSYRKWNLDLPQMATLYRLSHQLLSDVVDQNYFHMFDLNSFLTAKALNVAIPGGPRFEPLYKDIDPNDEDFSEFNAIDRIIFRAPIRTEYRVAFPFLYNTLPRSVKVSWYSHPQVVYVRTDNHPNLPAFYFDPVINPISSRSVAPKNITVSHEDEIFGPGGYEDDFELPAEVEPFFADEDLYTPETASAIALWWAPHPFNKRSGKMVRAQDVPLVKHWYLEHCPQGQPVKVRVSYQKLLKTYVLNELHRKKPKAQNKQDLLKTLKSTKFFQQTTIDWVEAGLQVCRQGFNMLNLLIHRKNLTYLHLDYNFNLKPVKTLTTKERKKSRFGNAFHLMREILRLTKLIVDAQVQYRLGNIDAFQLADGILYAFNHVGQLTGMYRYKYKLMHQIRSCKDLKHLIYYRFNSGPVGKGPGCGFWAPAWRVWLFFMRGIIPLLERWLGNLLSRQFEGRHSKGVAKTVTKQRVESHFDLELRASVMADLMDMMPEGIKQNKVNTVLQHLSEAWRCWKSNIPWKVPGLPAPIENIILRYVKSKADWWISVAHYNRERIRRGATVDKTVAKKNLGRLTRLWLKAEQERQHNYLKDGPYVSSEEAVAIYTTMVHWLESRKFSPIPFPSVSYKHDTKILILALERLRESYSVKGRLNQSQREELALIEQAYDSPGTTLARIKRFLLTQRAFKEVGIDMNDNYSNINPVYDVEPIEKITDAYLDQYLWYQAEQRHLFPAWIKPSDSEVPPLLTYKWAQGINNLSNVWETADGETNVMIETELSKVYEKIDLTLLNRLLRLIMDHNLADYITSKNNVQLSYKDMNHTNSYGLIRGLQFSGFVFQFYGLMIDLLLLGLQRASEMAGPPQSPNDFLQFRDRATETRHPIRLYTRYIDKIWVFFRFNADESRDLIQRFLTENPDPNFENVIGYKNKKCWPRDCRMRLMRHDVNLGRAVFWDLKNRLPRSITTIEWDDTFASVYSKDNPNLLFSMSGFEVRILPKCRNLNEEFSVKDSVWSLVDNSTKERTAHAFLQVTEEDIQKFNNRIRQILMSSGSTTFTKIANKWNTALIALFTYYREAAVSTVNLLDTIVKCETKIQTRVKIGLNSKMPSRFPPAVFYTPKELGGLGMISGSHILIPASDKRWSKQTDTGITHFRAGMSHDEETLIPNIFRYIIPWEAEFIDSQRVWMEYSQKRMEAQQQNRRLTLEDLEDSWDRGLPRINTLFQKDRSTLSFDKGFRLRAEFKQYQLMKSNPFWWTSQRHDGKLWNLNAYRTDVIQALGAFPSWEGLFWEKACLANGTQLLRYDGTKVNVEDVKEGDLLLGPDGGPRRAFNVVSGKDRLYRIKIDGDKEDLVVTANHILVLHRAKAMNTSVCFDRSKEQQGGAGEQLDISEVSAAERYDTVEMTAAEFAALHPQERSWYRAIRCPGFELPEQDVPVNPYFLGLWLGDESRNQSAIYSNHEEALREFLVSHAAELDMHLVYHGQSAYSTVCNKDRPTNKRIGPANQTQTVRPTIRQTRRTIRQQRLAAEHAAAEYTTQRETASLTPLLESPTSDKHGLLSSVETPGRLSDSVTTELPMSRSASAMRSIRTASGLSEFNDVTNVSASMPDIQNSGIKNQGRIAKVTRQQDSKGEVDFRQQYSQAIKDDLELLETDIEDDVASSDEIEDVCVVGSENELIGSEKQDQSGRRRQIHRLRTGHRGYGDLSDDEQEQLLDSVVERYAGDSRLNTLQQELSKMGILNPETGPINDKKRIPQVFMQNSRSVRLSVLAGLLDSDGWYIYPENMFGFAQSELCHKELFWDVVTLARSLGFGVWTKKRMMPDPTGKRMSPMLVAQISGDLAEIPCVLARKKAMPRLIPQSHSFAIKDISLESEATEWAGFRVDKDQLYLRHDYVVLHNSGFEESMKFKKLTNAQRSGLNQIPNRRFTLWWSPTINRANVYVGFQVQLDLTGIFLHGKIPTLKISLIQIFRAHLWQKIHESVVMDLCQVFDQELEQLGIEAVQKETIHPRKSYKMNSSCADILLFATNKWNVTRPSILFDTKDVYEPTTTNKFWLDVQLRYGDYDSHDIERYVRAKYLDYTTDSMSIYPSATGLMIAIDLAYNLYSAYGQYFPGLKTLIQQAMAKIMKANPALYVLRERIRKGLQLYASESNQEFLNSQNYSELFSPQIQLFIDDTNVYRVTIHKTFEGNLTTKPINGAIFIFNPRTGQLFLKIIHTSVWAGQKRLGQLAKWKTAEEVAALIRSLPVEEQPKQLIVTRKGLLDPLEVHLLDFPNISIRASELQLPFQAAMKVEKLADMILRATEPQMVLFNLYDEWLKTISPYTAFSRLILILRALHVNIDKAKIILRPDKSVITLEHHIWPSLSDEDWMKVEVQLRDLILNDYGKKNNVNVQSLTSSEVRDIILGMEISAPSLQRQQAAEIEKQQEEAKQLTAVTTKTQNVRGEDIIVTTTSQYEQQSFASKTEWRTRAIATSNLRTRANNIYVSSDDIRDEGYTYIMPKNILKRFIMIADLRVQVAGFLYGSSPPDNDQVKEIRTIVMVPQVGNTREVQLPQQLPQHDYLNSLEPLGVIHTISGNEPPYMTAQDVTQHSRLMNAHSSWDKKTVTMTVSFTPGSVSLAAWGLTPQGYKWGAENRDTTSDQPQGFSTSMGEKCQLLLSDKIRGYFLVPEDNVWNYSFMGSSYGSVEKRPVYVKIDTPLRFYDDQHRPLHFQNFAELEDIWVDRSDNFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B5E3</accession>
    <accession>C8V491</accession>
    <name>Q5B5E3_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_04237</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF74419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_661841.1">
        <property type="nucleotide sequence ID" value="XM_656749.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B5E3"/>
    <dbReference type="STRING" id="227321.Q5B5E3"/>
    <dbReference type="GeneID" id="2873660"/>
    <dbReference type="KEGG" id="ani:ANIA_04237"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN4237"/>
    <dbReference type="eggNOG" id="ENOG502R4KZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008827_0_0_1"/>
    <dbReference type="InParanoid" id="Q5B5E3"/>
    <dbReference type="OMA" id="LKEHTWV"/>
    <dbReference type="OrthoDB" id="3210378at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="512"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="513"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF74419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="776" mass="86071" checksum="0C8C0D5AC1261CE4" modified="2005-04-26" version="1">MSVVANRPESASMPYTAIPHSHSYSDSVYGSSVPSIPSRTSSVSSFKTNYTASTIPTSYSPTFSGSYRTCDSAASLDKILESVFKRVPQEVYENILDQLQFLHSGPNQSGCMTCFQRDLHALSLTCRPWEKAVRSRLYNRIHIVGSDSPAQLKKYRLKRGSRLKLLRRTLRERKLLANLVLELRVPQIDLLFTTGKHTAQWQEYRDLIASVVMVCPNLERLLGLTIPFNHEFDRLTHALSTRRKLKEHTWILCEATETSEASPRSTSCPGSLGPLQMFEFLNYHASWTNLETLMLYGLDRTALEPSVFLRTIDLLPSLRNLCVSNFDADAFSDTALLCLPSLESLRLENLPGVTDAGLAQYTSRPESSTLKSLTLIEPNIDSLLVISKILASLQSLERFKIVQTEKCPTLNTDGIVFQPLLASSSLRFLHWDVACPNPSTALSRLDFAPFAKPLQHTEAPNSHLAQSILCGGFPRLDALRAPSDIEPPGALQAVCQPIPRGQALLQPDRYSLPRSSHGSVQTRPMALPGGNNLTSARIRAQTFIDMAARDTETGLQVLITDHSDSYVPDNALEGSDDEAENELDETGMWEIPQDRPKPNPIPEDHEGPITVFDFRMPAYMGRTGAKISERDISIPRFILRPDIVGQDADGGLVSWRHILAANQSFTFAAGVGVNCFGSKGVSSPTIEEPLSPTSTSTPRFGWGSIASITSTMATSPVTPTTPPTPMSMSTMSVPPWEKDVCTGSWNYSHKGGRDWWFHMERERPVKAELYDVKRLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="128" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B5P0</accession>
    <accession>C8V4Z0</accession>
    <name>Q5B5P0_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">3-phytase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ANIA_04140</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF74618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_661744.1">
        <property type="nucleotide sequence ID" value="XM_656652.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B5P0"/>
    <dbReference type="GeneID" id="2873565"/>
    <dbReference type="KEGG" id="ani:ANIA_04140"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN4140"/>
    <dbReference type="eggNOG" id="KOG1225">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013427_0_0_1"/>
    <dbReference type="InParanoid" id="Q5B5P0"/>
    <dbReference type="OMA" id="ACRGDNT"/>
    <dbReference type="OrthoDB" id="10045365at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016158">
        <property type="term" value="F:inositol hexakisphosphate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003431">
        <property type="entry name" value="B-propeller_Phytase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050969">
        <property type="entry name" value="Dev_Signal_Modulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14949:SF56">
        <property type="entry name" value="EGF-LIKE-DOMAIN, MULTIPLE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14949">
        <property type="entry name" value="EGF-LIKE-DOMAIN, MULTIPLE 7, 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02333">
        <property type="entry name" value="Phytase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50956">
        <property type="entry name" value="Thermostable phytase (3-phytase)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51662">
        <property type="entry name" value="BP_PHYTASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030175771" description="3-phytase" evidence="5">
        <location>
            <begin position="20"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="domain" description="BPP" evidence="7">
        <location>
            <begin position="12"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="355"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="BPP" evidence="7">
        <location>
            <begin position="381"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="315"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="359"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="377"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBF74618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="736" mass="78219" checksum="128067BE85193C9B" modified="2005-04-26" version="1">MHLPYALGVLLVSAAGSIASPLTGNLAVSSLSTEVESDQTAFYYGTARSRSFLIGNDGSAATGGIRSFSLQNLNETARVKPGRTKVAGLLYDVGHRDLVVSIAAPDSIIRVFDVNGLGEIPSTRKKALGDWSCLCTWTSSSGGKYFYLLGKKQGIQFLVREKGSKVEVLEVQTFPLPVEPSSCAVSPEDNVVYFAAEDKTIYSFAAAESTTAPDIQTLGQVSDEISGLAVYVSAATQYLFVTQSDKVEVYTPELEQVGSLAVTGVEDLEIAGTSIYQSNSSQYPYGLLGFAIESDSGNAFGVASLEPAFTSLKLQPNTSYTPRRSSGQSGPKQNGFPSANNTLSCFAGWTGSDCTEITCHNNCSRHGTCLGPNECKCRSHWAGPECSWIGVEAKYETDANGGDGDDPAIWISPANLNRSTIITTTKSEIGAGLAVFDLKGNLLQTVAAGEPNNVDIIYGFQAGRRTIDLAYAACREDDTLCLFEITPDGLLTSIPGGRQPTPEDYTVYGSCSYRSPSNGKQYLFVNEKSGLYLQYELTSSPNGTLATTLVRKFTGGSGGQPEGCVADEENGYIFLGEEPLGLWRYEAEPTGSPNGTLIAKVGDGTIYADVEGVTLLPGQTPEQGLIIVSCQGVSAYSVYRRAEPHDHVLTFTIGESGDGSVDGVTNTDGVTGVSTGLNDDFPRGLLVVHDDANQLSTGETAELASFKLVSLEDVLAAAGKRTWLFEEVDETWDPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B620</accession>
    <accession>C8V5Q6</accession>
    <name>Q5B620_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ADP-ribosylhydrolase ARH3</fullName>
            <ecNumber evidence="2">3.2.1.143</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">ADP-ribose glycohydrolase ARH3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">ADP-ribosylhydrolase 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">O-acetyl-ADP-ribose deacetylase ARH3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Poly(ADP-ribose) glycohydrolase ARH3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">[Protein ADP-ribosylarginine] hydrolase-like protein 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">[Protein ADP-ribosylserine] hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">ANIA_04010</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>alpha-NAD(+) + H2O = ADP-D-ribose + nicotinamide + H(+)</text>
            <dbReference type="Rhea" id="RHEA:68792"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:57967"/>
            <dbReference type="ChEBI" id="CHEBI:77017"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="12">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ADP-ribosylglycohydrolase family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.143" evidence="2"/>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF74892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_661614.1">
        <property type="nucleotide sequence ID" value="XM_656522.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B620"/>
    <dbReference type="GeneID" id="2873420"/>
    <dbReference type="KEGG" id="ani:ANIA_04010"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN4010"/>
    <dbReference type="eggNOG" id="ENOG502SHFY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_388180_0_0_1"/>
    <dbReference type="InParanoid" id="Q5B620"/>
    <dbReference type="OMA" id="SGWDTDC"/>
    <dbReference type="OrthoDB" id="44736at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004649">
        <property type="term" value="F:poly(ADP-ribose) glycohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4080.10">
        <property type="entry name" value="ADP-ribosylation/Crystallin J1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.560">
        <property type="entry name" value="Exo-inulinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050792">
        <property type="entry name" value="ADP-ribosylglycohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005502">
        <property type="entry name" value="Ribosyl_crysJ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036705">
        <property type="entry name" value="Ribosyl_crysJ1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16222">
        <property type="entry name" value="ADP-RIBOSYLGLYCOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16222:SF24">
        <property type="entry name" value="ADP-RIBOSYLHYDROLASE ARH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03747">
        <property type="entry name" value="ADP_ribosyl_GH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101478">
        <property type="entry name" value="ADP-ribosylglycohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="12">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="296"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00041057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00042471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00042722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00042850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00043187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00043193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR605502-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CBF74892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="717" mass="78096" checksum="E7BBEE7EEF59CEB8" modified="2005-04-26" version="1">MTSTPQAKPSTYLPPDYLERVYAGVLGKLVGVYMGRPFEGWTHQRILAELGHIRYYVHDKFNEPLVVVDDDISGTFQFIRALEEHGISDGITSEDIGRTWLNTVIEDRTIFWWGGRGVSTEHTAFLNLKNGIHAPSSGSCQTNGKTVSEQIGAQIFIDGWGIVSPGNPLQAAKLAHAAGSVSHDGESVYAAQLWAAMEAEAFVSKDIDHLLDTGLSVIPGDSLVAHVVGRVHEWVKDDRDWLKTRQRIEDTYGYDKFHGVCHVIPNHAIMIMTVIYAGHDFDEAMHIINTCGWDTDCNSGNVGCLVAIMLGLTCFEGKYDWRGPLADRVLLSTAEVGYSINNAARIAIDIVNMGRQLAGHSRLPPPKGGAQFHFGLPGSVQGFQVVNQHTPDDRGSVTVRQDVDVEGNAGLAIHLDSMKSLIEVSTPVFGSLEELTKSLYSFSASPLLYPGQTISAKFLSNIESGSSANVGLRVQAYGEDDSIKILDGPSISALSGSLQSLSWTIPDETDGRPLQRVGLCIQSTDPGSVNGTIWLDSLRWDGSPRLVLRRPSTQPGQAWHRSWINNVTKMHPDISSHSLVLSQSHGEGIAMYGARGWTNYRILVPKLKVSMGTPVGMAVRVQGLNRYYALLLVEERRVALVKAKDEQRITLASATFDWSVDGEYDFALEADGTSIRGRVQGVEITASDDQYSEGGIGLVVTEGAICVDSIEISPLGD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2010-05-18" modified="2026-01-28" version="103" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B6C6</accession>
    <accession>C8V6A2</accession>
    <name>BGLF_EMENI</name>
    <protein>
        <recommendedName>
            <fullName>Probable beta-glucosidase F</fullName>
            <ecNumber>3.2.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Beta-D-glucoside glucohydrolase F</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Cellobiase F</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Gentiobiase F</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">bglF</name>
        <name type="ORF">AN10482</name>
    </gene>
    <organism>
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Beta-glucosidases are one of a number of cellulolytic enzymes involved in the degradation of cellulosic biomass. Catalyzes the last step releasing glucose from the inhibitory cellobiose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text>Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <comment type="sequence caution" evidence="4">
        <conflict type="erroneous gene model prediction">
            <sequence resource="EMBL-CDS" id="EAA58835" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EC" id="3.2.1.21"/>
    <dbReference type="EMBL" id="AACD01000063">
        <property type="protein sequence ID" value="EAA58835.1"/>
        <property type="status" value="ALT_SEQ"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF75129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B6C6"/>
    <dbReference type="SMR" id="Q5B6C6"/>
    <dbReference type="STRING" id="227321.Q5B6C6"/>
    <dbReference type="CAZy" id="GH3">
        <property type="family name" value="Glycoside Hydrolase Family 3"/>
    </dbReference>
    <dbReference type="GlyCosmos" id="Q5B6C6">
        <property type="glycosylation" value="8 sites, No reported glycans"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CBF75129">
        <property type="protein sequence ID" value="CBF75129"/>
        <property type="gene ID" value="ANIA_10482"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AN10482"/>
    <dbReference type="eggNOG" id="ENOG502QR4D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007314_0_0_1"/>
    <dbReference type="InParanoid" id="Q5B6C6"/>
    <dbReference type="OMA" id="PAPYGGW"/>
    <dbReference type="OrthoDB" id="416222at2759"/>
    <dbReference type="UniPathway" id="UPA00696"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.300:FF:000002">
        <property type="entry name" value="Probable beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1700:FF:000003">
        <property type="entry name" value="Probable beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019800">
        <property type="entry name" value="Glyco_hydro_3_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF2">
        <property type="entry name" value="BETA-GLUCOSIDASE F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00775">
        <property type="entry name" value="GLYCOSYL_HYDROL_F3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword id="KW-0136">Cellulose degradation</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0326">Glycosidase</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0624">Polysaccharide degradation</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000394114" description="Probable beta-glucosidase F">
        <location>
            <begin position="21"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="731"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="285"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="257"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="328"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="360"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="395"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="421"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="726"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="868" mass="93918" checksum="2CBEC9AF65A2E6F2" modified="2010-05-18" version="2" precursor="true">MAHRWLILALVAAAAPRALASPGPSLNERQSDDEPFSPPYYPAPNGGWVSTWAEAYEKAHSIVSNLTLAEKVNLTTGTGIFMGPCAGQTGSVPRLGIPNLCLHDSPLGVRNTDHNTAFPPGITVGATFDKSLMYERGVGLGEEARGKGVNVLLGPSVGPLGRKPRGGRNWEGFGFDPVLQGIGGAETIKGMQSTGLIACIKHFVGNEQEMHRMSSVVTQGYSSNIDDRTLHELYIWPFAEGVRAEVGSVMIAYNDVNKSSCSQNSKLINGVLKDELGFQGFVVTDWLAHYGGVSSALAGLDMDMPGDGAVPLFGNSYWGPELSRSILNGTVPVERLNDMVTRILATWYKMGQDQDYPLPNFSSNTEDEKGLLYPGAVISPIGVVNQYVNVQGNHNITARAIARDAITLLKNEGDLLPLRRNDSLKVFGTDAGPDPQGLNSCADKGCNRGVLTMGWGSGTSKLPYLITPQEAIANITPTAEFFITDSFPSSVDANDEDIAIVFINSDSGENYITVDGNPGDRKTSGLHAWHNGDELVKAAAERFSQVVVVIHTVGPIILEEWIDLDSVKAVLIAHLPGQEAGYSLTDVLFGDYSPSGHLPYTIPYQESNYPSSVGLLQQPFGQIQDYYTEGLYIDYRHFLKEDITPRYAFGHGLSYTTFEFSEPALSVVTPLDSAYPPSRPAKGPTPTYPNTIPPASEAAWPAKFNRIWRYIYPYLNNPQADAAVANSSKTYPYPDGYSTDPQPPPRAGGAEGGNPALWDVAFSVQVTVTNTGQHSGRAVAQLYVELPDSLGLDTPSRQLRQFEKTKVLETGQSETLTLEVTRKDVSVWDVEVQDWKTVVGGEGVKIHIGESVLDIRTECEVGGRCVTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B6W7</accession>
    <accession>C8V7J3</accession>
    <name>Q5B6W7_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_03713</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF75553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_661317.1">
        <property type="nucleotide sequence ID" value="XM_656225.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B6W7"/>
    <dbReference type="GeneID" id="2873123"/>
    <dbReference type="KEGG" id="ani:ANIA_03713"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN3713"/>
    <dbReference type="HOGENOM" id="CLU_1677864_0_0_1"/>
    <dbReference type="InParanoid" id="Q5B6W7"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010332148" evidence="1">
        <location>
            <begin position="26"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF75553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="157" mass="17020" checksum="CAD83ACFF2BB45B0" modified="2005-04-26" version="1">MGMAWRLFPGSWMDALIMIHGKLIALLVCFQPDAGSGGGMTDSLSAYGAAFVLYIVRPFYYEYTSSPSSESAWISSFIVIDNSSPVPPAFCRSLEPPVDPVRPSSLSLILQVRRVSTVNILLSMFGISTSMGVSINARHGPSTPLIVYSLVAEHRSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="126" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B7A0</accession>
    <accession>C8V4E9</accession>
    <name>Q5B7A0_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Lysine-specific histone demethylase Aof2, putative (AFU_orthologue AFUA_4G13000)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ANIA_03580</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the flavin monoamine oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF75843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_661184.1">
        <property type="nucleotide sequence ID" value="XM_656092.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B7A0"/>
    <dbReference type="STRING" id="227321.Q5B7A0"/>
    <dbReference type="GeneID" id="2872997"/>
    <dbReference type="KEGG" id="ani:ANIA_03580"/>
    <dbReference type="eggNOG" id="KOG0029">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004498_1_2_1"/>
    <dbReference type="InParanoid" id="Q5B7A0"/>
    <dbReference type="OMA" id="WCAENPF"/>
    <dbReference type="OrthoDB" id="9982100at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033193">
        <property type="term" value="C:Lsd1/2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031934">
        <property type="term" value="C:mating-type region heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005721">
        <property type="term" value="C:pericentric heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140720">
        <property type="term" value="C:subtelomeric heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140682">
        <property type="term" value="F:FAD-dependent H3K4me/H3K4me3 demethylase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140683">
        <property type="term" value="F:histone H3K9me/H3K9me2 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990841">
        <property type="term" value="F:promoter-specific chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040029">
        <property type="term" value="P:epigenetic regulation of gene expression"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140718">
        <property type="term" value="P:facultative heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033696">
        <property type="term" value="P:heterochromatin boundary formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071515">
        <property type="term" value="P:mating-type locus imprinting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031508">
        <property type="term" value="P:pericentric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030466">
        <property type="term" value="P:silent mating-type cassette heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00084">
        <property type="entry name" value="HMG-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000064">
        <property type="entry name" value="Lysine-specific histone demethylase 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000249">
        <property type="entry name" value="Lysine-specific histone demethylase Aof2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.10:FF:000067">
        <property type="entry name" value="Lysine-specific histone demethylase Aof2, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.660.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050281">
        <property type="entry name" value="Flavin_monoamine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007526">
        <property type="entry name" value="SWIRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742">
        <property type="entry name" value="FLAVIN MONOAMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742:SF386">
        <property type="entry name" value="LYSINE-SPECIFIC HISTONE DEMETHYLASE 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04433">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50934">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SWIRM" evidence="7">
        <location>
            <begin position="167"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="97"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="861"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1070"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1121"/>
            <end position="1165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1183"/>
            <end position="1257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="877"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="1132"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1153"/>
            <end position="1165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1190"/>
            <end position="1207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1221"/>
            <end position="1246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBF75843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="1274" mass="138222" checksum="5B0B6C68A6DE81E9" modified="2005-04-26" version="1">MTEVPFVAMRAPGSYSSQTETIRQYIPSSVVVNSSCPPAKQLQQPDRVQPQQCTTNSWSVHNDGFGPRPQVSNAKSYGVDAGNQGINYMSYDLVKETNGSTPNDSTSTPVLSASSNGKSTTPSSVNLASSSTSVSSTKADDTPGPVFFRPRSSIPTRLPTAVYAQQCVAAAYASRLNPYALHPKEQEALQDHLCHLHVTVYLNIRNGILRLWTRNPMVSVSKEEALGCAKDYRWMNLASFAYEWLIRNGYINFGCLEIPEGLVPSKKGRRKEGPVIVIIGAGMAGLGCARQLEGFFKHFRDNLNSPRVVVLEGRRRIGGRIYSHPLQSRQSSTLPPGLTPKVEMGAQIVVGFDRGNPLDQIIRGQLALSYHLLRDISTIYDIDGTPVDEVRDATAERLYNDVLDRSGDYRYKSVVAPTAEGERDLIDLGRDITTSDGVTVRQYEEARQAGTVGLLFPAKRIRRGVGHKTAELKPATGPVVDTDEAEENPAVVACEAMGWKLNPGISVSQRINLDPIAKASKFQTLGKTMDEGVRQYQRMLPLTPKDLRLLNWHFANLEYANATNINNLSLSGWDQDMGNEFEGEHSQIIGGYQRVPYGLWSYPTKLDVRTNKTVSRITYDASGSNRHRTVVHCEDGESITADMVVYTGSLGTLQHRTVQFSPPLPDWKVGAIDRLGFGVMNKVILAFDQPFWDTERDMFGLLREPTNRDSMAQEDYASNRGRFYLFWNCMKTTGLPVLIALMAGDAAHQAERTPDAEIVAEVMSQLRNVFKQVAVPDPLETIITRWASDKFTRGTYSYVAAEALPGDYDLMAKSVGNLYFAGEATCGTHPATVHGAYISGLRAASEIIDSILGPIPIPTPLVPEKGKNTNSGNTNGMPSNTPHIPLDTDTNTPEVPPQQPQLPTSTSTVTSSFEPLSRAAYDQAMNAAVYTEIGPPIPRPGRPGINPFILYQKDFMAKARADCDAEYQAITKDPNAKAPRDTVRAALGLMWRQAPEEVKRPYLEQAEVNRQTGAEIAAKWKRDNVEWERRKEAAKKRWQQDNPFEWWVATEFGEPPRKKLDSTNKELGAAYSPAAAPTPPFGPSTSSGLAGISTPSAASPYPSGTSAGLAGSSTLFTNGYDANASTPAATPSHPPPSVPPPGLSEATAGNTESCSSSASYSAPAGPSTVPLFGPLPGSAKMSKPNVNGYSANESTPAAAAVASQSLQPPQPPGSPSGLYGGSTQDTNGSTNLNANPNPGQTQNPNVANGPRPGMGWSWFNNNSATAYSFLLNQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="101" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B7H5</accession>
    <accession>C8V536</accession>
    <name>Q5B7H5_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ATP-grasp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ANIA_03505</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the D-alanine--D-alanine ligase family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF76018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_661109.1">
        <property type="nucleotide sequence ID" value="XM_656017.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B7H5"/>
    <dbReference type="STRING" id="227321.Q5B7H5"/>
    <dbReference type="GeneID" id="2872928"/>
    <dbReference type="KEGG" id="ani:ANIA_03505"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN3505"/>
    <dbReference type="eggNOG" id="ENOG502QPTY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_784577_0_0_1"/>
    <dbReference type="InParanoid" id="Q5B7H5"/>
    <dbReference type="OMA" id="HGVKLCH"/>
    <dbReference type="OrthoDB" id="422362at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008716">
        <property type="term" value="F:D-alanine-D-alanine ligase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011095">
        <property type="entry name" value="Dala_Dala_lig_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23132">
        <property type="entry name" value="D-ALANINE--D-ALANINE LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23132:SF23">
        <property type="entry name" value="D-ALANINE--D-ALANINE LIGASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07478">
        <property type="entry name" value="Dala_Dala_lig_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="4">
        <location>
            <begin position="151"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBF76018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="380" mass="41433" checksum="DFE917A97D513F29" modified="2005-04-26" version="1">MLASHTVRRASKIGPSRHARTLTNAPTVAVLYQAIEPPVINGVRKPRKPGGYQDSGADIVYTLQQKGIQVIKADPSAPVSSNEGWTFPDTEEGIYSAVHQGATHLWANTILFSSHPLQTSARLTPLADKIYVVGQPPGLVENFDDKAYLNGKLAQIGGFTLPKSWLATSENIQQLVQQVDRYPIVGKPVRGRGSHGVKVCRDKQQLLQHTKTLLAESPLVMLEEFLAGEEATITVMPPTPSDPHHWSTVPVNRFNHDDGIAPYNGVVAVTANSRVVTEEELKDPAYGKIMRQCEKVAQLIGATAPIRVDVRRFSPGSDFALFDINMKPNMTGPGRPGREDQASLTAIAASAMGWDYGTLLENILEGAQPLSVFRNYSNPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B8L1</accession>
    <accession>C8VIK1</accession>
    <name>Q5B8L1_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nucleoside-diphosphate-sugar epimerase, putative (AFU_orthologue AFUA_3G12770)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ANIA_03119</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF83372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_660723.1">
        <property type="nucleotide sequence ID" value="XM_655631.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B8L1"/>
    <dbReference type="STRING" id="227321.Q5B8L1"/>
    <dbReference type="GeneID" id="2873998"/>
    <dbReference type="KEGG" id="ani:ANIA_03119"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN3119"/>
    <dbReference type="eggNOG" id="KOG2774">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_19_0_1"/>
    <dbReference type="InParanoid" id="Q5B8L1"/>
    <dbReference type="OMA" id="KSWPTQF"/>
    <dbReference type="OrthoDB" id="16464at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05238">
        <property type="entry name" value="Gne_like_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050005">
        <property type="entry name" value="DenD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF043036">
        <property type="entry name" value="ErythonDh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43103:SF3">
        <property type="entry name" value="ADP-L-GLYCERO-D-MANNO-HEPTOSE-6-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43103">
        <property type="entry name" value="NUCLEOSIDE-DIPHOSPHATE-SUGAR EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="3"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBF83372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="316" mass="34421" checksum="E9663F17B9362762" modified="2005-04-26" version="1">MHILITGAAGFIGQLLARELLNDPSYTLVLTDINEPPIPAGVKYPQNARTVTADLVKAADTVVDKSLDAVYAFHGIMSSGSEANFDLGMTVNVDATRKLLEALRATCPGVRVIYSSSQAVYGQPLPEVVDDTVIPTPQSSYGAEKLICETLVNEYTRRGFITGFTLRFPTISVRPGRPTAAASSFLSGMIREPLNGEECVIPLEDRSFKSWLCSPKTLVHNLILTLSLPADSLPLHIRQVNVPGICVTVQEMMDALAKIGGEDKLALLKEKEDPTLRPILDSWPTRFDNSQAISLGMKRDSSFEAAVRDYQLSLSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="105" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B8V3</accession>
    <accession>C8VIU6</accession>
    <name>Q5B8V3_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Sulfhydryl oxidase</fullName>
            <ecNumber evidence="8">1.8.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ANIA_03027</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
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            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
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            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="12">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
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            <text>2 R'C(R)SH + O2 = R'C(R)S-S(R)CR' + H2O2</text>
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    </comment>
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        <property type="entry name" value="ERV/ALR sulfhydryl oxidase domain"/>
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        <property type="entry name" value="FAD-LINKED SULFHYDRYL OXIDASE ALR"/>
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        <property type="entry name" value="Evr1_Alr"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="FAD-dependent thiol oxidase"/>
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        <property type="entry name" value="ERV_ALR"/>
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    </evidence>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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    <reference evidence="5" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
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            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
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            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
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        <property type="protein sequence ID" value="CBF84101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="InParanoid" id="Q5B9N5"/>
    <dbReference type="OMA" id="EQHPSMR"/>
    <dbReference type="OrthoDB" id="10264728at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031416">
        <property type="term" value="C:NatB complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004596">
        <property type="term" value="F:protein-N-terminal amino-acid acetyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032956">
        <property type="term" value="P:regulation of actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000058">
        <property type="entry name" value="N-acetyltransferase (Nat5)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051646">
        <property type="entry name" value="NatB_acetyltransferase_subunit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45910">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45910:SF1">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="2"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBF84101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="173" mass="20195" checksum="019686F4AF7DF9D6" modified="2005-04-26" version="1">MTSIRRMSPTDLFSLNLTNLDPLTENYDLGFYLNYLMRWPSLFSSVKDRREGIAGYIMGKLEEQHPSLKASEHYTPWHGHITVLTVAPAWRRLGHARRLTERLERGSDINNAWFVDLYSVFRRVVNYYSDDPTGMSEKGEDAFDMRKPCSRDKKLEHIRENGENFPVSPEHVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="113" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B9Q9</accession>
    <accession>C8VK07</accession>
    <name>Q5B9Q9_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Short chain dehydrogenase, putative (AFU_orthologue AFUA_1G17650)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ANIA_02721</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF84149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_660325.1">
        <property type="nucleotide sequence ID" value="XM_655233.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B9Q9"/>
    <dbReference type="GeneID" id="2873879"/>
    <dbReference type="KEGG" id="ani:ANIA_02721"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN2721"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_3_1"/>
    <dbReference type="InParanoid" id="Q5B9Q9"/>
    <dbReference type="OMA" id="QVNDEDW"/>
    <dbReference type="OrthoDB" id="37659at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF13">
        <property type="entry name" value="CHAIN DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17650)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBF84149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="260" mass="27954" checksum="CB3EEF5ABB937F49" modified="2005-04-26" version="1">MSSSSLKVALVTASSAGLGAAIAKVLAANMRVIINYSSDAQRAELVQEEMSSIAGSESVLNDQGEKQPRFAAIRADLANRADIKKLVAETVSMMGRLDVVVSNGGWTRIRKFDDLDQNVDEEDWDRCYEINVKSHLYLLHEARVHLDAAQGSFVTVASVAGVKPSGSSIPYSVTKAAQIHMVKCLAHAVGPNIRVNSVSPGILLTDWGRQFPEEHLQAAKDGTLLKRFATVEDVAQAVKLLALNSSLTGHNLIIDSGFSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="102" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BA31</accession>
    <accession>C8VKL9</accession>
    <name>Q5BA31_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">beta-glucosidase</fullName>
            <ecNumber evidence="4">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">ANIA_02599</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="4"/>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF87174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_660203.1">
        <property type="nucleotide sequence ID" value="XM_655111.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BA31"/>
    <dbReference type="STRING" id="227321.Q5BA31"/>
    <dbReference type="GeneID" id="2875306"/>
    <dbReference type="KEGG" id="ani:ANIA_02599"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN2599"/>
    <dbReference type="eggNOG" id="ENOG502QR4D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_717676_0_0_1"/>
    <dbReference type="InParanoid" id="Q5BA31"/>
    <dbReference type="OrthoDB" id="47059at2759"/>
    <dbReference type="UniPathway" id="UPA00696"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019800">
        <property type="entry name" value="Glyco_hydro_3_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF3">
        <property type="entry name" value="BETA-GLUCOSIDASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00775">
        <property type="entry name" value="GLYCOSYL_HYDROL_F3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 3 N-terminal" evidence="11">
        <location>
            <begin position="83"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CBF87174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="385" mass="42392" checksum="67A8FADB4388E4BA" modified="2005-04-26" version="1">MNKPEGTRIDATRAQVIPARQTAMMTDMKKRPILPRVILPQQKLVKAMEGSRKLSFQGTTSEPYNRALMGWASFLQRRHVTLNASSEILSDILRREWNWNGLVISDWGATNTVGPSLKAGMDLEMPGPPLKRTEEAVKEAIKNGEVSVEQAEGSARRLLHLLQRAERFEDASDVAEALPLRPLNPPKKLAIVGPNAKRTVADGGGSAYIKAPYWASVLESLKAEFGPRGTDCPSCGVQGIGPSKLFVDGKELASESGKRQPDGELFCTYGSDPTNCPCFRFTCIQTTTLAASQTALRIFENSEIKAGEACVAELEIDAYSLGVFDALVNRWAIDAVAEFDIVVSTQTLAMRLWLAKLGFQKKSLWCILYKRLFSKDPLFFPLAVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="102" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BB83</accession>
    <accession>C8VMI7</accession>
    <name>Q5BB83_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Dimethylaniline monooxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ANIA_02197</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FMO family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF86364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_659801.1">
        <property type="nucleotide sequence ID" value="XM_654709.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BB83"/>
    <dbReference type="GeneID" id="2875655"/>
    <dbReference type="KEGG" id="ani:ANIA_02197"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN2197"/>
    <dbReference type="eggNOG" id="KOG1399">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006909_5_3_1"/>
    <dbReference type="InParanoid" id="Q5BB83"/>
    <dbReference type="OMA" id="WHYDPIP"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000960">
        <property type="entry name" value="Flavin_mOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000332">
        <property type="entry name" value="FMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00419">
        <property type="entry name" value="ADXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBF86364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="480" mass="53285" checksum="65703172BF31B468" modified="2005-04-26" version="1">MAPRYDSVAVIGTGPSGLSTLKALVDEGTFSRIRVFERRDRVGGLWHYDPVPDVFPTPGAPHIRNEIPASLPAFTEPVAEDTTARTGIHDQLDSNVGSGTMSFTHTPFPEVNSAVSVRQLGRGNPSRPFRVVSGYLEDLARPYLDRISFNTTVERVEKIDNRKKWRITARQSGHFQRNKPAEYWWQEEFDAVVVASGHYNVPLIPEIDGLAEAHKALPGHFEHSKSFRSANDYVDKRVVLVGGNISSADLIADLHAVVRGNLYLSQRGGNEALANVFSLPGVEIRPTIGRVDAEKAGLTVTFTNGSTVADVDKLIFATGYRLVYPFLVPDPVTPSNRVAGLYQHIFKIGDPSFAMVGQVRGALSFRVYEYQAVAVARYFANHNAKPLPSPAEQDEWEVGRLKYKGPTTLFHEIKPDFKEYFEYLREFAGPPGPGTNGYELPVFGEDWPNLGFAILQLKDKYWQSIKAASQNGKEKVQAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BCF7</accession>
    <accession>C8VPD0</accession>
    <name>Q5BCF7_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_01773</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF85534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_659377.1">
        <property type="nucleotide sequence ID" value="XM_654285.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BCF7"/>
    <dbReference type="STRING" id="227321.Q5BCF7"/>
    <dbReference type="GeneID" id="2874757"/>
    <dbReference type="KEGG" id="ani:ANIA_01773"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN1773"/>
    <dbReference type="eggNOG" id="ENOG502SAXX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043406_0_0_1"/>
    <dbReference type="InParanoid" id="Q5BCF7"/>
    <dbReference type="OMA" id="PFAQTAS"/>
    <dbReference type="OrthoDB" id="2402960at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
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    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
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        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="390"/>
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    </feature>
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        <location>
            <begin position="30"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="56"/>
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    <feature type="compositionally biased region" description="Basic residues" evidence="1">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF85534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="390" mass="42341" checksum="273048F225543A01" modified="2005-04-26" version="1">MAEIPGLDEFAQTRGADDLFDDEIIPVSAEEQQTIIEPEPESQAQSQAQSEPHQAVNEKDIERDREASSTPVYSDGARSRGGERRGKGRGRGGRGRGARDSGLGSGPRRPNWALNDPGDAGVENGTKAREGEKATETPAAEKEEPGQEDNNTADAPRVPAVRGDRSATGGVKKPKLTEEELSRRIAAAREKSAKLAAAHARAEADQASFMEREKIAEQKRREERANRRVMDNERERNRLRKLEALNGREWDADKPEEQFSGRGGRGQYRRGMHGGVSGYTRRVEESPGDGELDPDTQPHDSGHGYRGRGRGGRGRGGRGRGGHRGDKPDTTSQNKAAPPTPVITNEEEFPSLPGGEKKEKESAPASGESLKPLSPVTGGTWADQMEAHEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BCK9</accession>
    <accession>C8VP20</accession>
    <name>Q5BCK9_EMENI</name>
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            <fullName evidence="10">Lysosomal cystine transporter family protein (Eurofung)</fullName>
        </submittedName>
    </protein>
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        <name evidence="10" type="ORF">ANIA_01721</name>
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        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
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        <dbReference type="NCBI Taxonomy" id="227321"/>
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            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
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            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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            <taxon>Aspergillus subgen. Nidulantes</taxon>
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    <reference evidence="11" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the MPDU1 (TC 2.A.43.3) family.</text>
    </comment>
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        <property type="protein sequence ID" value="CBF85433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="XP_659325.1">
        <property type="nucleotide sequence ID" value="XM_654233.2"/>
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    <dbReference type="AlphaFoldDB" id="Q5BCK9"/>
    <dbReference type="STRING" id="227321.Q5BCK9"/>
    <dbReference type="GeneID" id="2875720"/>
    <dbReference type="KEGG" id="ani:ANIA_01721"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN1721"/>
    <dbReference type="eggNOG" id="KOG3211">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_053568_0_1_1"/>
    <dbReference type="InParanoid" id="Q5BCK9"/>
    <dbReference type="OMA" id="LQVLYYW"/>
    <dbReference type="OrthoDB" id="271506at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
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        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="entry name" value="mannose-P-dolichol utilization defect 1 protein"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016817">
        <property type="entry name" value="MannP-dilichol_defect-1"/>
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    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12226">
        <property type="entry name" value="MANNOSE-P-DOLICHOL UTILIZATION DEFECT 1 LEC35 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12226:SF2">
        <property type="entry name" value="MANNOSE-P-DOLICHOL UTILIZATION DEFECT 1 PROTEIN"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="232"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="261"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="278"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBF85433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="311" mass="32707" checksum="3C896E7ABF69EB53" modified="2005-04-26" version="1">MDVIQKTLVEPLQPYLRPVVASVPQPVHDAIVSLIGSSCHNTLVVNLDLAQDPECTSLAISKALGIGIVGASGIVKVPQILKLIRSGSSAGVSFVSYALETASLLITLSYGVRNQFPFSTYGESAFIAAQDVLVGVLVLTYAGRSAAAAAFVAVVAASIYSLLVDTSIVDAQTMAYLQAGAGALGVASKVPQILTIWQEGGTGQLSAFAVFNYLAGSLSRIFTTLQEVDDKLILYGFLAGFSLNLILAAQMLYYWNSPTKTEKEEASRSRKPAIKAETSSFRRSPASSASPSTASPSPKPSGRTPTTRRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BCQ4</accession>
    <accession>C8VNS4</accession>
    <name>Q5BCQ4_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Prolyl 4-hydroxylase alpha subunit domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ANIA_01676</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF85347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_659280.1">
        <property type="nucleotide sequence ID" value="XM_654188.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BCQ4"/>
    <dbReference type="GeneID" id="2875003"/>
    <dbReference type="KEGG" id="ani:ANIA_01676"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN1676"/>
    <dbReference type="eggNOG" id="ENOG502S6FN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041456_2_1_1"/>
    <dbReference type="InParanoid" id="Q5BCQ4"/>
    <dbReference type="OMA" id="YEDTRKC"/>
    <dbReference type="OrthoDB" id="69177at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004656">
        <property type="term" value="F:procollagen-proline 4-dioxygenase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.620:FF:000045">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045054">
        <property type="entry name" value="P4HA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869:SF241">
        <property type="entry name" value="FE2OG DIOXYGENASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prolyl 4-hydroxylase alpha subunit" evidence="6">
        <location>
            <begin position="37"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBF85347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="279" mass="31963" checksum="117864AC7199048A" modified="2005-04-26" version="1">MAFGKDQFLPSQPPANARCRVIDFASTEPPLPEYKRYLAAVIDNALTETECKELLRLAEASTADGKWERAMINVGGGRQKISTDSRNSSRIILDSPEIAEKLQARLLPFLRELEVDRLENKPLITGLAGRNRTYKFTRLNERLRFLKYVGGEYFRPHWDAHYTTPDRRERSYFTIQLYLNGDGEQDLQELKCAIDAEGPEGSERGCMNLDVEGRLLGGATSFLPRYEEKERHVRIFPRTGSALVFQQSELLHSGDPVFRGTKFTLRMDVMYELVESESY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="125" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BDP5</accession>
    <accession>C8VS45</accession>
    <name>Q5BDP5_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Target of rapamycin complex subunit LST8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ANIA_01335</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat LST8 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF87695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="XP_658939.1">
        <property type="nucleotide sequence ID" value="XM_653847.2"/>
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    <dbReference type="AlphaFoldDB" id="Q5BDP5"/>
    <dbReference type="FunCoup" id="Q5BDP5">
        <property type="interactions" value="560"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5BDP5"/>
    <dbReference type="GeneID" id="2877090"/>
    <dbReference type="KEGG" id="ani:ANIA_01335"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN1335"/>
    <dbReference type="eggNOG" id="KOG0315">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_57_5_1"/>
    <dbReference type="InParanoid" id="Q5BDP5"/>
    <dbReference type="OMA" id="VQRNYKH"/>
    <dbReference type="OrthoDB" id="400at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
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    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="C:TORC1 complex"/>
        <property type="evidence" value="ECO:0000318"/>
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        <property type="term" value="C:TORC2 complex"/>
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        <property type="project" value="GO_Central"/>
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    <dbReference type="GO" id="GO:0043539">
        <property type="term" value="F:protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0030950">
        <property type="term" value="P:establishment or maintenance of actin cytoskeleton polarity"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="P:fungal-type cell wall organization"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="P:mitochondria-nucleus signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="P:regulation of actin cytoskeleton organization"/>
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    <dbReference type="GO" id="GO:0001558">
        <property type="term" value="P:regulation of cell growth"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="P:TOR signaling"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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    <dbReference type="GO" id="GO:0038202">
        <property type="term" value="P:TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000923">
        <property type="entry name" value="Protein transport protein (LST8), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000318">
        <property type="entry name" value="WD repeat-containing protein pop3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037588">
        <property type="entry name" value="MLST8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19842">
        <property type="entry name" value="G BETA-LIKE PROTEIN GBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19842:SF0">
        <property type="entry name" value="TARGET OF RAPAMYCIN COMPLEX SUBUNIT LST8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="71"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="112"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="203"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="332"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="257"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="267"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBF87695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="393" mass="42988" checksum="B4592E103EA5C477" modified="2005-04-26" version="1">MSVILCTAGYDHTIRFWEALSGICSRTIQHPDSQVNRLCITPDKRYLAAAGHNNVKLYDIKSTNPNPVMTFEGHTNNITGVAFHCEGKWMVTSSEDGTVKVWDTRTGSLQRNYAHKAPVNDVVIHPNQGELISGDRAGIVRVWDLGESVCTHQLIPEDDVAVHSVSVASDGSLLCAGNKKGNVYIWRMIQEAEVTRIVPICTFQAHKDYLTRVLLSPDVKHLATCSADHTAKVWNLDLDFPPAKTAIAAAARSKVKSPSAAEVKPASPSSAGSESQSNSMQLERGKADSIPFHLLNGTQPANNVEPPPSFPVQPDGPPMDPNTGTLFLETTLANHQRWVWDCAFSADSAYLVTVSSDHYARLWELASGQIIRQYSGHHRGAVCVALNDYSEPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BE17</accession>
    <accession>C8VSS9</accession>
    <name>Q5BE17_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7603 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ANIA_01213</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF87924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_658817.1">
        <property type="nucleotide sequence ID" value="XM_653725.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BE17"/>
    <dbReference type="STRING" id="227321.Q5BE17"/>
    <dbReference type="GeneID" id="2876993"/>
    <dbReference type="KEGG" id="ani:ANIA_01213"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN1213"/>
    <dbReference type="eggNOG" id="ENOG502QU2M">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002590_0_0_1"/>
    <dbReference type="InParanoid" id="Q5BE17"/>
    <dbReference type="OMA" id="DQKWQCE"/>
    <dbReference type="OrthoDB" id="5395440at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056023">
        <property type="entry name" value="DUF7603"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18947:SF28">
        <property type="entry name" value="GIRDIN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18947">
        <property type="entry name" value="HOOK PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24554">
        <property type="entry name" value="DUF7603"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7603" evidence="3">
        <location>
            <begin position="744"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="35"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="227"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="572"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="413"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="831"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="924"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="145"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="175"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="190"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="302"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="591"/>
            <end position="603"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBF87924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="994" mass="109129" checksum="8C09726AFD911018" modified="2005-04-26" version="1">MAPGWSPPSPGIRARASVTDTLSAGAYLPEATIVSGVPAHPLPSPKPDPTATVVRRKPLPASSPVIAARSRRSGPSLSVSSSSSLYSTRSLSQADPPARASPLQSPASHYSHSRNSSVANSLSSFVSNSAAQSSVRGEPSLFARRTIDKTDRFPRSSPLKTPLRIDTSASTVNVDGDDDSDDSDDDITNLYKSQFTNGTPIHSRLVSEPFIPVLPSPINYKRATTMALHPPTNRPPPLHIDSNARSMSSGGNDPRQPKTPGSKISSFFGWRAATSPGAESSSTEISDGGRSPLPSPMPPSIPSTSFSITPSTSIPFDPTARPNVGYPVRNGSLSSAGILESSSSALVAELENELREISSELAGSIRREMELEDLVERLQSEMPSEAPNRRTSDYFSDSGSSSIRYAYESAGRIEDIEKYKRAAEQERAQLRAELGQRLQEERTRRTASESHVQILEAQVAQLRRERTEHSDLASKTRELESALEGTRRKLAEERQIKDNFEDLLTAMRVELEQLRTERDLLREGQPLSDPAEVQRLKEEIEALKIENAALSQLQGSRFASIAEEEGPVKRNSAFGLSRSNSLARMPRKSSSRSGSLSRSNSVSAKDRATPPQESLADRVEGAEAQRDALHGALKRLLDRQAYEARQTEKRIRAMELELARAQEAGSPRKLGYEREVRNLRDEVNHLRMRAEDALEQKWQCEKGLAGLKMDLDRAEQETASLRILLQEHDIAVPAELADNALGGDAFAEVIATSSSLESAYQQLQADREEAEASVAHSPNVDDAELAESFNRTDTLAQHVRQQLASNTALRARLAAAINKGEKDQQLSAARINEMQARLKEMEDSLLAAQQHADDEISRHEDEVRQLQESHNAQLLRMKNGSRSPAALSPIIGSGGPNTPFMVKSPRLDKTTSGDGVALTQVVKSEMLDQRVKELEKLLREADREMGEVVSRMNRAQIDVAELQAARDEALRETRRLQQEILTERNVFKNLLGRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BEL2</accession>
    <accession>C8VU46</accession>
    <name>Q5BEL2_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Avl9 protein, putative (AFU_orthologue AFUA_1G12950)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ANIA_01018</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AVL9 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF88325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_658622.1">
        <property type="nucleotide sequence ID" value="XM_653530.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BEL2"/>
    <dbReference type="FunCoup" id="Q5BEL2">
        <property type="interactions" value="231"/>
    </dbReference>
    <dbReference type="GeneID" id="2876795"/>
    <dbReference type="KEGG" id="ani:ANIA_01018"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN1018"/>
    <dbReference type="eggNOG" id="KOG3823">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009066_0_1_1"/>
    <dbReference type="InParanoid" id="Q5BEL2"/>
    <dbReference type="OMA" id="TWDDAHP"/>
    <dbReference type="OrthoDB" id="192887at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018307">
        <property type="entry name" value="ABL9/DENND6_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051731">
        <property type="entry name" value="DENND11/AVL9_GEFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037516">
        <property type="entry name" value="Tripartite_DENN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31017:SF1">
        <property type="entry name" value="LATE SECRETORY PATHWAY PROTEIN AVL9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31017">
        <property type="entry name" value="LATE SECRETORY PATHWAY PROTEIN AVL9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09794">
        <property type="entry name" value="Avl9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50211">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDENN" evidence="3">
        <location>
            <begin position="10"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="515"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="603"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="686"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="515"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="526"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="542"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="609"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="648"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="689"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="722"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="745"/>
            <end position="754"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBF88325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="801" mass="89447" checksum="276E3810716A2EE0" modified="2005-04-26" version="1">MSHTRVYKDPIVLVIDFHHARGPEIELCIGPEGTDPAAENDWSLLPFMALSDGAHMSTEEFSYFTLRRRGTDTEPPTSLFGIACSRQIDSNALIYKPPDVTRSTVQKAVVVVTENPKCLGQLREKLSVVTSAWFAQRDFSDLDILKKFREGLVISLQKDEGFKDQTLGLSLREMIHDYKYQTLVLFKALLLQPKMLFFGSRCERLCMIQFSLVSLIPGLMNHLQDCADPSFDTYAQTVKKPTSLKTSDRSSLLAYMGLPLQIFGKGSMFGPYTPLQQLDLLADDGTKSYVVGSTNSLLLQQKDRYSDILINLDEDTINITSSSLRNALTLSVADRRWIDAITQIVNDTWDEAHPNQPKTHGYMGSEEFIRLQFEEYLLALLSCMKYHEELNSYLTGEPSRRNRAQLDSYNIEGDPALEFNQEFLAHWRTTSNYALFQRLTSDALLFSVAEPRHPSAGGLTIDDVQRRISQQVADLHLDEKVREGREALNRHLSTGQKKVSAAFNSFWADIEAMREAQRKRNEEKAATQSPRPSLDRSSTLPTSHSDSTSNSSTSASSWFPNRKVAVPAVDMTQAQASVSAVGQKAGAYFSSWGTWASEKRKEWQEKKSASSSPTASAAVTSPSTPTLASTTESIDTTNTNTDKDRRQSFQSFRSEASSTISRSGSRRKRLSNLFFKRESLDFNVGAISRDGDDHETVYPKSPLSREESILGDDIPETSAEQYKGERKLDIHPKTEADVAERKDTTVNNVPSDGTRTPPPQQPAAALDSIELEPRANLPGSESEKVVVQSSKSTNENEPPLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="130" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BET2</accession>
    <accession>C8VUH1</accession>
    <name>Q5BET2_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC ATPase, putative (AFU_orthologue AFUA_1G16440)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ANIA_00948</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF88465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_658552.1">
        <property type="nucleotide sequence ID" value="XM_653460.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BET2"/>
    <dbReference type="STRING" id="227321.Q5BET2"/>
    <dbReference type="GeneID" id="2876723"/>
    <dbReference type="KEGG" id="ani:ANIA_00948"/>
    <dbReference type="eggNOG" id="KOG0062">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_36_6_1"/>
    <dbReference type="InParanoid" id="Q5BET2"/>
    <dbReference type="OMA" id="RQIAHME"/>
    <dbReference type="OrthoDB" id="2110130at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
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    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="CDD" id="cd03221">
        <property type="entry name" value="ABCF_EF-3"/>
        <property type="match status" value="2"/>
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    <dbReference type="FunFam" id="3.40.50.300:FF:003119">
        <property type="entry name" value="ABC ATPase, putative (AFU_orthologue AFUA_1G16440)"/>
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        <property type="entry name" value="Putative ABC transporter ATP-binding component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
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    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
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    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
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    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
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    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
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    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF135">
        <property type="entry name" value="ATPASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G16440)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="46"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="487"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="209"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBF88465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="744" mass="83218" checksum="93F3B9B8CB62403B" modified="2005-04-26" version="1">MTHSIIATCKQTRFHIDDKPSREVDIEGLTVAVSSVPESVEDPSRTKAKGKSKSKAEARELISDAHLRLKAGVHYGLIGRNGTGKSTLLRAVADKLVPGIPHSTRIAILQQTDTASEDGYAPFYDRTEDQGASEGKFVLDYVMSSDQFRNEVTRKMNFLSKCFETEDPLEPVRGIRRIRHEDTEKQLFLARKNASLRSGARGLQARKELKAVEARFELSRELLEQAKEDIDAEIIKQETQAAIETLQDLQSQFEAMKLVDIEQQASQILTGLGFKEDALSKPFSTLSGGWRMRCMLASVLIQNPDIMILDEPTNFLDLLGVIWLEEYLKQLRDSTQTTVVVVSHDRDFVNAVCEEIVILRDQKLTYFKGNLSAYEQDFEEQKLYWGRMKEAQERQIAHMEATVREGIKVGKKTNDENKLRMAKSRQKKLDNRMGVQVNARGGRFKLNRDLAGWHSSARAEIEVPQDEKGALIALPDPPELRFPGPLISLEGITFKYKTDASPVLKGVDLVMHLGDRVGLMGLNGCGKSTLIRLVAGISVPTQGKVSSHSRLRMGYYAQHSIEELKTRGLGDPSLTALGLMTKDVDGSLNEGQLRGLLSSLGLQGKIVSDVPILRLSGGQLVRLALARIIWNAPHLLVLDEITTHLDYHTVTALATVLSTFKGAILLVSHDRFMVRAVIEGKRDLDHKLDDDFEGVEEESDMELPRRRVVYVMKAGTMTVQDDGVEQFEKSLVKRVQKMLHSARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="117" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BFD0</accession>
    <accession>C8VQY3</accession>
    <name>Q5BFD0_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidase A2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ANIA_00750</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF88858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_658354.1">
        <property type="nucleotide sequence ID" value="XM_653262.1"/>
    </dbReference>
    <dbReference type="GeneID" id="2876526"/>
    <dbReference type="KEGG" id="ani:ANIA_00750"/>
    <dbReference type="eggNOG" id="KOG4177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_249748_0_0_1"/>
    <dbReference type="InParanoid" id="Q5BFD0"/>
    <dbReference type="OMA" id="WAPDINQ"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025676">
        <property type="entry name" value="Clr5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051165">
        <property type="entry name" value="Multifunctional_ANK_Repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001995">
        <property type="entry name" value="Peptidase_A2_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123:SF33">
        <property type="entry name" value="PROTEIN HOS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14420">
        <property type="entry name" value="Clr5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50175">
        <property type="entry name" value="ASP_PROT_RETROV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="444"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A2" evidence="5">
        <location>
            <begin position="461"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="519"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="724"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="952"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="987"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1022"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1215"/>
            <end position="1237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1312"/>
            <end position="1357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1344"/>
            <end position="1357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBF88858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="1479" mass="161953" checksum="0C1FE9EAAA6A2072" modified="2005-04-26" version="1">MEDSLWEAYKPELHRLYIREGMTLSAVMEYMESKYSFGKTKAQYTKHFGKWGFQKNQKVSASDAVFIERRIQKRKQVFDKESEVYIDGVEYPSKKRKKAPYGKAYVSTTERLRLAGAPSPCTPEGIVVCTPATPGMWLNWDLSLPWLRFSKLLRPPTQDEDLLSTSPTLAVTSPRGTNVSSYAPNMELLKRLGSVVPWNRLTHPPNVNSCSRTATALSIIMPAESEGQLRGLASRFAESKQSTIDILGVELFLLSNNLVSHGPDGKTFGSMRSHDQRVLEMFRLSSWNNVARLKVLVSSQEPTAGAIAEQLFASSVREMEIESVRMLLEAGMSPNGYIDTVDEGSLTPLQYATLALGSGDPKALQLLELLLSHGADLDKSSNDISPLGYALQIHSLEAIDELLSHGAYATPSCLAFAAYSLKDSELFKQLLGPDTDVNARSGLQGPSPLSQAVKGGNIEIIKVLLDRGADLNALVDIEFDGDWAVTTVLGYAVQSAGLEIIETLLHACLDVNPNIDGLPYASPLVLAVARAKANPRLVNLLLQKGFDIQIADDCGAQTLLERALKAKNTSLCEILIRNGARIDRPFSDKEHATSALVCAIQTGAAEVARLLIDMGARLNDSYSNSPGTVLGAAIERGDMIILDMAWTAGAVSVNPRLGRLGNMQTAVYLEQRGLLADILNMAGTPLLGAALSAKDDGLVWMLLSYTFELNRVTMDTRIHDHPVTYKDPLQAAIRNGRLSIAYALLDRGAKVTDSDIADVVMYLDSNDTTEGTELLQRLLKDFQGAAPTATAEAILSDRLDLFDSLLAARIDPRGKPQQFLDVWEFDTGRDYRLDPPESILEIVCQTGDMMVLETLFQACPWDSRLVGRALTLSILFNYTELFEYLFSWAPDINQEIAIHHLDTEDEEGLFVSGYTEVVTPLQVASRDQRVSVVQKLLGHPNIDVNYLGAGPRRRTALQHAVGNGNMELINLFLNRGADINGRPARDGGATALQIAAIQGYLGIAHRLIHLHANINAPPARINGRTALEGAAEYGRIDMLQMLLDSGASVTGDDGQRQYHRAIELAERNGHHAAARLLIAFEPQGVSLRRVDCNIVVLRDWQREELNDHGRQLYLSVVFVSAQSPGKNLQAERLQSFKSDSESENSNCETEDEPKTINVYAHHDSLNMRPVIQGSHELVRSKLVRTAVGQPGLQQRLLAQTAREEVINLTVKHSGGDCNAPDATETAQEGPGGGRDGDIGLWEGKWDACHSAGEEVYAGDWGGFLHRLEVDREEVSARRMKSTEATRRALPRKLAAEHVADGDFLVVDFEKGDDEEQRDAADGQVEIEDPTPGNTLGHETANNRAQREGDSKHRKDDTHAFGPLVQREEATAAEDIGHPAVKRLEGGHGEHICIGDPHLGIARVQATNDGGTAVEMTEASSADSNEVIVRAAKMAYLNDLLDQVQDGEHVDEALPRTASPFWPAVAAKTETGRGLWAWLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BGA3</accession>
    <accession>C8VTF6</accession>
    <name>Q5BGA3_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Clavaminate synthase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_00427</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF89506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_658031.1">
        <property type="nucleotide sequence ID" value="XM_652939.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BGA3"/>
    <dbReference type="STRING" id="227321.Q5BGA3"/>
    <dbReference type="GeneID" id="2876204"/>
    <dbReference type="KEGG" id="ani:ANIA_00427"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN0427"/>
    <dbReference type="eggNOG" id="ENOG502QRGK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045411_1_0_1"/>
    <dbReference type="InParanoid" id="Q5BGA3"/>
    <dbReference type="OMA" id="LYIHSRT"/>
    <dbReference type="OrthoDB" id="438224at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.330:FF:000033">
        <property type="entry name" value="Clavaminate synthase-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48420">
        <property type="entry name" value="NON-HAEM DIOXYGENASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48420:SF1">
        <property type="entry name" value="NON-HAEM DIOXYGENASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF89506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="362" mass="39575" checksum="E897EEE8F0C2B183" modified="2005-04-26" version="1">MASKPIKQAQAVTVSLQELIDGTVSFDTLTEAFGPSSLGIIVVKDLDPKFQHLRAQVLSNASYVAALKNDELESLTSPSAKYLIGWSCGKETLRSGHFDTLKGSYYVNCAFYKDPSLQGAPSDEHPDLPEYTAPNIWPDVQKLPNFRSGLEELCRLIIDTAVLVARACDRYAEGNIEGYKAGYLEKVVRGSLTTKARLLHYFPAPDGVHAEEARKDEENEEDDDWCATHLDHGCLTGLTSAMFVDEDAHPPASSSATSNLPELPASPDPKAGLYIQSRTGEVVKVNIPKDCLAFQTGEALQLITKGKFRAVPHFVKGAKVPKGQGKIARNTLAVFTQPNLGEEVEEGKTFADFAREVVERTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="135" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BGL6</accession>
    <accession>C8VU29</accession>
    <name>Q5BGL6_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Aspartate--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="3">6.1.1.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Aspartyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">ANIA_00314</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="16">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>tRNA(Asp) + L-aspartate + ATP = L-aspartyl-tRNA(Asp) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19649"/>
            <dbReference type="Rhea" id="RHEA-COMP:9660"/>
            <dbReference type="Rhea" id="RHEA-COMP:9678"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.12" evidence="3"/>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF89742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_657918.1">
        <property type="nucleotide sequence ID" value="XM_652826.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BGL6"/>
    <dbReference type="STRING" id="227321.Q5BGL6"/>
    <dbReference type="GeneID" id="2876090"/>
    <dbReference type="KEGG" id="ani:ANIA_00314"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN0314"/>
    <dbReference type="eggNOG" id="KOG0556">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004553_1_1_1"/>
    <dbReference type="InParanoid" id="Q5BGL6"/>
    <dbReference type="OMA" id="EYIVTHA"/>
    <dbReference type="OrthoDB" id="372395at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004815">
        <property type="term" value="F:aspartate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006422">
        <property type="term" value="P:aspartyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd04320">
        <property type="entry name" value="AspRS_cyto_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00776">
        <property type="entry name" value="AsxRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000013">
        <property type="entry name" value="Aspartate--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000132">
        <property type="entry name" value="Aspartyl-tRNA synthetase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02075">
        <property type="entry name" value="Asp_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004523">
        <property type="entry name" value="Asp-tRNA_synthase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024320">
        <property type="entry name" value="LPG_synthase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00458">
        <property type="entry name" value="aspS_nondisc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003483">
        <property type="entry name" value="PRK05159.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43450:SF2">
        <property type="entry name" value="ASPARTATE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43450">
        <property type="entry name" value="ASPARTYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09924">
        <property type="entry name" value="LPG_synthase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="14">
        <location>
            <begin position="291"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="19"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="50"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="70"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="80"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CBF89742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="956" mass="108876" checksum="2DCCF6C51F1A2913" modified="2005-04-26" version="1">MSIKRALSKIKPKLEENLPSPSSSRQGSSSRTSSPRRNILSSFLRDRDSASSSDDISDDASGAGSVSKNQQKRLARRQRKSEQRSRMSEDIGGSSESERRHKEEIDQAIREETPEMRARYGELPLLQSSTRKREKRLDFDTISADMVGQQVFFQARLHIIRRMSAKLVFLVFRQQLSTFQGVLHEEPGAKSIAMIQWAEHLKTGCIVQVRGTIKAPDVPVLGCTVHDVEVDIDEVHLVVRREDPVPFSVYEAEIRTAEEDLVEGRRSHISDRTRLTNRLLDLRTPTSQSIFRIQSAVCNLFRSALDEQRFIEIHTPKLQGAATESGASVFDVNYFGRDAFLAQSPQLAKQMAIAADFGRVYEIGAVFRAENSNTHRHLTEYTGLDIEMSIEEHYHEMLEVLDAVIKNILKGIYTRYRREIEIIKHQFPSEDLVWLDETPIIRFSDGIKMLNESGWRDDEGNPLAEDKDLGTRDEIRLGELVKEKYKTDYYVLDKFPVDARPFYAMPDPDDPRFTNSFDMFIRGQEIVSGGQRIHDPHMLEENMRRVGINPDTMEEYMEGFRWGAPPHAGAGIGLERMLMLILKLGNIRLASMFHRDPKSFPAKPPALQLRHPESSTIEPPWVKERRGTVAQSESELQPIEHLIANYGDATSTSWGDERFKIWRDMATGAAVSYVVSSNNYVVIPGNPLCDARQYGRVISQFLQWLRRETKYRPIWLLCSPEVETVLGEKLGWRSLSCIAEEVVEPARNQAAMDGELARKIRRTENEGIKIVTINQGEMVSESVREAIDKRIEDWKANRKGTQVHLSDIHPWRDHEHRWYFYAVDKEGTICAFVTLVLISPTYGMQVKYTFDFPGSPNGVIESLITHAIQTAGRSGVKKLTFGAGATNTLTPGHNMHGAKMKMLQHTYDALAKQFHLVRKSEFRAKLGAEDEPLYIAYPPHGLGQKGIRAILHFFED</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BHD0</accession>
    <accession>C8VR30</accession>
    <name>Q5BHD0_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Iso-orotate decarboxylase (Eurofung)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ANIA_00050</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF90301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_657654.1">
        <property type="nucleotide sequence ID" value="XM_652562.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BHD0"/>
    <dbReference type="STRING" id="227321.Q5BHD0"/>
    <dbReference type="GeneID" id="2875828"/>
    <dbReference type="KEGG" id="ani:ANIA_00050"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN0050"/>
    <dbReference type="eggNOG" id="KOG4245">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039329_4_0_1"/>
    <dbReference type="InParanoid" id="Q5BHD0"/>
    <dbReference type="OMA" id="RIESCIM"/>
    <dbReference type="OrthoDB" id="191270at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000055">
        <property type="entry name" value="Uracil-5-carboxylate decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="2-AMINO-3-CARBOXYLMUCONATE-6-SEMIALDEHYDE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240:SF28">
        <property type="entry name" value="ISO-OROTATE DECARBOXYLASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="4">
        <location>
            <begin position="5"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU366045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBF90301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="381" mass="41945" checksum="17B0C68FB733C0D8" modified="2005-04-26" version="1">MPLIVDVHTHVYPPAYMQMLRSRKTVPYVHDPSNNRDPRLIILSSDDDASIPLDQRGRPVDSSYWDINVKLSFMRQHGINCSVISLANPWLDFVEPAEAQMWAERINDDLEKTCATVNKAADPGNTLTLDQKETLFAFGALPLSAPSSESVVAEIKRLKTLEHLRGVIMGTSGLGKGLDDARLDPVWEALQETDMLMFLHPHYGLPEEAYGGPETTGRYGHVLPLALGFPLETTIAVTRMLLSGVFDRFPRLKILLAHSGGTLPFLAGRIESCILHERKFISGGGDVQGPQRSVWDVLKTNIYLDAVVYGKPGLEAAMTASGSDRLLFGTDHPFFPPLDSKDNSWPSVTTNYQAIHATFDTNSKTVADVLGGNAARILNLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>C8V017</accession>
    <name>C8V017_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">L-lactate dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ANIA_05842</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the LDH/MDH superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF70728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467078.1">
        <property type="nucleotide sequence ID" value="XM_050612706.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V017"/>
    <dbReference type="STRING" id="227321.C8V017"/>
    <dbReference type="GeneID" id="2870742"/>
    <dbReference type="KEGG" id="ani:ANIA_05842"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN5842"/>
    <dbReference type="eggNOG" id="KOG1495">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045401_1_2_1"/>
    <dbReference type="InParanoid" id="C8V017"/>
    <dbReference type="OMA" id="THLDSMR"/>
    <dbReference type="OrthoDB" id="6270329at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004459">
        <property type="term" value="F:L-lactate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006089">
        <property type="term" value="P:lactate metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042867">
        <property type="term" value="P:pyruvate catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00300">
        <property type="entry name" value="LDH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="entry name" value="Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001557">
        <property type="entry name" value="L-lactate/malate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022383">
        <property type="entry name" value="Lactate/malate_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001236">
        <property type="entry name" value="Lactate/malate_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43128">
        <property type="entry name" value="L-2-HYDROXYCARBOXYLATE DEHYDROGENASE (NAD(P)(+))"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43128:SF16">
        <property type="entry name" value="L-LACTATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02866">
        <property type="entry name" value="Ldh_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00056">
        <property type="entry name" value="Ldh_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000102">
        <property type="entry name" value="Lac_mal_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00086">
        <property type="entry name" value="LLDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="LDH C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0520">NAD</keyword>
    <keyword evidence="1 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactate/malate dehydrogenase N-terminal" evidence="6">
        <location>
            <begin position="9"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Lactate/malate dehydrogenase C-terminal" evidence="7">
        <location>
            <begin position="150"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="14"/>
            <end position="19"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="123"/>
            <end position="125"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBF70728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="318" mass="33970" checksum="1EBEE80273A75C18" modified="2009-11-03" version="1">MDNLKRASRIAIVGVGQVGAAAAYALVLGSIADELLLVDTRAAWRDGQVRDLSDAAYASRSKTRVYSATYREASQCDIVVITAGSKYLYGQTSMDYLYRNTSIVRSIINEMKPFRSDTVLLIVANPVDLMTSLAKELSNLPSAQVLGSGTFLDSIRLRGLLADETGLAPNSLDLYVLGTHGDSAVAAWSCAAVGGVPLKDALGLEKRVEESLVEECKHRSQSIVRAKGATTFGIGSIVCSICASVLLDRHNVRPVSHYQPQHGCCFSLPAVLGRKGIVQTFPVPLSAAEQEGIAQSVGALKSTLNRVLEEEKGNRSTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>C8V025</accession>
    <name>C8V025_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ANIA_11491</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF70743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467082.1">
        <property type="nucleotide sequence ID" value="XM_050612724.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V025"/>
    <dbReference type="GeneID" id="74897067"/>
    <dbReference type="KEGG" id="ani:ANIA_11491"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN11491"/>
    <dbReference type="HOGENOM" id="CLU_3032317_0_0_1"/>
    <dbReference type="InParanoid" id="C8V025"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF70743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="55" mass="5977" checksum="0DEB52B0389CA8CE" modified="2009-11-03" version="1">MGGEGKRKNSDGEIAKRTNNNFDCYRTMDASELKRAKALLAGLAPIQLSRATPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>C8V0U9</accession>
    <name>C8V0U9_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Calcineurin subunit B</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Calcineurin regulatory subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Protein phosphatase 2B regulatory subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ANIA_06566</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Composed of a catalytic subunit (A) and a regulatory subunit (B).</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the calcineurin regulatory subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF70998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467122.1">
        <property type="nucleotide sequence ID" value="XM_050613084.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V0U9"/>
    <dbReference type="FunCoup" id="C8V0U9">
        <property type="interactions" value="838"/>
    </dbReference>
    <dbReference type="STRING" id="227321.C8V0U9"/>
    <dbReference type="GeneID" id="2870688"/>
    <dbReference type="KEGG" id="ani:ANIA_06566"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN6566"/>
    <dbReference type="eggNOG" id="KOG0034">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061288_10_1_1"/>
    <dbReference type="InParanoid" id="C8V0U9"/>
    <dbReference type="OMA" id="DTNFDRD"/>
    <dbReference type="OrthoDB" id="191686at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005955">
        <property type="term" value="C:calcineurin complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004723">
        <property type="term" value="F:calcium-dependent protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008597">
        <property type="term" value="F:calcium-dependent protein serine/threonine phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019902">
        <property type="term" value="F:phosphatase binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097720">
        <property type="term" value="P:calcineurin-mediated signaling"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071444">
        <property type="term" value="P:cellular response to pheromone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000747">
        <property type="term" value="P:conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006873">
        <property type="term" value="P:intracellular monoatomic ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000047">
        <property type="entry name" value="Calcineurin subunit B type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45942">
        <property type="entry name" value="PROTEIN PHOSPATASE 3 REGULATORY SUBUNIT B ALPHA ISOFORM TYPE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="28"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="67"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="97"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="138"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CBF70998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="181" mass="20665" checksum="5C563918C4A5DE5A" modified="2009-11-03" version="1">MYSRRRRSSLGTSQIFENIISGSNFDKDEVDRLRKRFMKLDKDNSGTIDRDEFLSLPQVSTNPLATRMIAIFDEDGGGDVDFQEFVSGLSAFSSKGNKEEKLRFAFKVYDIDRDGYISNGELFIVLKMMVGNNLKDVQLQQIVDKTIMEADKDHDGKISFEEFTDMVESTDVNLSMTLNQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>C8V1N5</accession>
    <name>C8V1N5_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_10852</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF71273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467148.1">
        <property type="nucleotide sequence ID" value="XM_050610979.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V1N5"/>
    <dbReference type="GeneID" id="74896641"/>
    <dbReference type="KEGG" id="ani:ANIA_10852"/>
    <dbReference type="HOGENOM" id="CLU_2223258_0_0_1"/>
    <dbReference type="InParanoid" id="C8V1N5"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF71273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="106" mass="11454" checksum="4CEBC544645D9281" modified="2009-11-03" version="1">MKGTFSSFSRGQSILSEPPPLRLSTLELSASRASPCAPPAMRPPRHRRLSSASETSCCSLLGVSARPHPRSASASCSCRRPLHLQWSPRHRSPPPTARSPTRSAEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>C8V3R4</accession>
    <name>C8V3R4_EMENI</name>
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        <recommendedName>
            <fullName evidence="7">AP-3 complex subunit delta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ANIA_08291</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Adaptor protein complex 3 (AP-3) is a heterotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF74291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467303.1">
        <property type="nucleotide sequence ID" value="XM_050611258.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V3R4"/>
    <dbReference type="FunCoup" id="C8V3R4">
        <property type="interactions" value="611"/>
    </dbReference>
    <dbReference type="STRING" id="227321.C8V3R4"/>
    <dbReference type="GeneID" id="2869000"/>
    <dbReference type="KEGG" id="ani:ANIA_08291"/>
    <dbReference type="eggNOG" id="KOG1059">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001908_3_0_1"/>
    <dbReference type="InParanoid" id="C8V3R4"/>
    <dbReference type="OMA" id="CIHTIII"/>
    <dbReference type="OrthoDB" id="10264595at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030123">
        <property type="term" value="C:AP-3 adaptor complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017105">
        <property type="entry name" value="AP3_complex_dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22781:SF12">
        <property type="entry name" value="AP-3 COMPLEX SUBUNIT DELTA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22781">
        <property type="entry name" value="DELTA ADAPTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037092">
        <property type="entry name" value="AP3_complex_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="9">
        <location>
            <begin position="3"/>
            <end position="590"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="866"/>
            <end position="934"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="883"/>
            <end position="899"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR037092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBF74291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="934" mass="104465" checksum="5E4BC6F666D713B1" modified="2009-11-03" version="1">MDKKATALLKLAYLEMFGYDMSWASFNVLEVMSSSKFLQKRVGYLGALQSFRPETEVLMLATNLLKKDMVCSNLQIISLPLNTLPNIITPSLAMSLLPDVLSRISHSSPSIRKKAVVCLYRLALVYPEALRLAWPRLKDRLMDETEDSSVTTAVLNVVCELGWRRPHDFLPLAPRFFELLVEGGNNWMSIKIIKLFATLTPLEPRLVRKLIRPLINIVQTTTAMSLLYECINGIIQGGILEGEGALEDSHEIADLCVSKLRGMVVTDFDPNLKYVALLAFSRIVVSHPHLISMHQDVIMNCLEDADISIRLQALELAARMVTGDTLQPVVERLIGQLEEPQHTFPKGDASDAGDVAVLANHVGRRELGKHPAYFPISDEYRVEILHRVLDICSHDNYSRLTDFEWYVSVLIRLVKHLPTRVEEHTVSQGFESSSRDDAASRIGLEMRNIAVRVKNVRMEATRAAEFLLLVDNRQSVFANVSLAYNGVLGPLAWVVGEYAEYLSSPGPMLQSLIDVSTTSLSGRALVLFVQAVPKVLARIVHDYMGTWDVRQRSEVSLFLARIVEFYEGLATHPDLEVQERAIEFLEIMRLAADVMQTSTQQAQVPYLLSSIIPSLFYGLELNPVAPNAQGKVPLPDQLCLNVPFNDNVRKLFESYQDGFYAQPYDFYRVGVTQLPHKQQGGFNTIEIQPNFSYQDPDILDEALAASLRQKLEWKQRNREDPFYIGADERNDATAPTERPFGSVHSEALDVDSIPIIDLKISGLGDESTPKARSYDSQGKLAGQPKKYEVIADEVLDLEETADFSSPDEPVKAKRALLQVDSSGLKDLTLGDDGLAHANGVPGKSEDDAEMATAMKEIEKIRLKMQRASERVELEGAPSDGMVVKKRRKPKKTSHNKTRKGYSLQGENSQSEHGKSSSTVHKRTRKRKGDAERLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>C8V454</accession>
    <name>C8V454_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">histone acetyltransferase</fullName>
            <ecNumber evidence="3">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">ANIA_03621</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="17">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetyltransferase family. GCN5 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="3"/>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF75756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467513.1">
        <property type="nucleotide sequence ID" value="XM_050611487.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V454"/>
    <dbReference type="FunCoup" id="C8V454">
        <property type="interactions" value="437"/>
    </dbReference>
    <dbReference type="STRING" id="227321.C8V454"/>
    <dbReference type="GeneID" id="2873041"/>
    <dbReference type="KEGG" id="ani:ANIA_03621"/>
    <dbReference type="eggNOG" id="KOG1472">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015741_1_1_1"/>
    <dbReference type="InParanoid" id="C8V454"/>
    <dbReference type="OMA" id="HQPPKEW"/>
    <dbReference type="OrthoDB" id="1937912at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140671">
        <property type="term" value="C:ADA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000123">
        <property type="term" value="C:histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046695">
        <property type="term" value="C:SLIK (SAGA-like) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140068">
        <property type="term" value="F:histone crotonyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010484">
        <property type="term" value="F:histone H3 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036408">
        <property type="term" value="F:histone H3K14 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043993">
        <property type="term" value="F:histone H3K18 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140129">
        <property type="term" value="F:histone H3K56ac reader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043992">
        <property type="term" value="F:histone H3K9 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140011">
        <property type="term" value="F:histone H4K12ac reader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140046">
        <property type="term" value="F:histone H4K16ac reader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010515">
        <property type="term" value="P:negative regulation of induction of conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045815">
        <property type="term" value="P:transcription initiation-coupled chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd05509">
        <property type="entry name" value="Bromo_gcn5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000004">
        <property type="entry name" value="Histone acetyltransferase KAT2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018359">
        <property type="entry name" value="Bromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037800">
        <property type="entry name" value="GCN5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45750">
        <property type="entry name" value="GH11602P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45750:SF3">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00633">
        <property type="entry name" value="BROMODOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7 12" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="5" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="15">
        <location>
            <begin position="77"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="14">
        <location>
            <begin position="319"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="24"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CBF75756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="414" mass="47754" checksum="97E356AC8DE791D9" modified="2009-11-03" version="1">MTESGLQAAKMSCLDCESSILTESRPRRKAESLGGGSFPRFSTTEQENSHRFSRAGTEEAAAANRSFSREEERRGEIEFRVVNNDGSRDSFIVLTGLKCIFQKQLPKMPKDYIARLVYDRSHLSIAIVKHPLEVVGGITYRPFNSRRFAEIVFCAISSDQQVKGYGAHLMSHLKDYVKATSDIMHFLTYADNYAIGYFKKQGFTKEIQLDRSIWMGYIKDYEGGTIMQCTMLPKIRYLESGRMLLKQKEAVHAKIRAFSKSHIIHPPPKEWKNGPVKIDPLSIPAIKESGWSPDMDELARQPRHGPNYNQLLHLLNDMQNHSAAWPFTQPVNKDEVLDYYEVIKEPMDLSTMEEKHEKDMYPTPQDFIKDAVLMFDNCRRYNNENTPYAKSANKLEKFMWQQIRNIPEWSVSTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C8V468</accession>
    <name>C8V468_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Choline/carnitine acyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ANIA_10447</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the carnitine/choline acetyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF75783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467518.1">
        <property type="nucleotide sequence ID" value="XM_050611492.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V468"/>
    <dbReference type="STRING" id="227321.C8V468"/>
    <dbReference type="GeneID" id="74896406"/>
    <dbReference type="KEGG" id="ani:ANIA_10447"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN10447"/>
    <dbReference type="eggNOG" id="KOG3717">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013513_5_1_1"/>
    <dbReference type="InParanoid" id="C8V468"/>
    <dbReference type="OMA" id="IGHITHT"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004092">
        <property type="term" value="F:carnitine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009437">
        <property type="term" value="P:carnitine metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.70">
        <property type="entry name" value="Choline/Carnitine o-acyltransferase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000542">
        <property type="entry name" value="Carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039551">
        <property type="entry name" value="Cho/carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042231">
        <property type="entry name" value="Cho/carn_acyl_trans_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589:SF103">
        <property type="entry name" value="CARNITINE O-ACETYL-TRANSFERASE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589">
        <property type="entry name" value="CARNITINE O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00755">
        <property type="entry name" value="Carn_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00440">
        <property type="entry name" value="ACYLTRANSF_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Choline/carnitine acyltransferase" evidence="7">
        <location>
            <begin position="65"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="33"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="33"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600542-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBF75783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="629" mass="71240" checksum="FD6396EF70E44B31" modified="2009-11-03" version="1">MQAPMQTSEVLDAPSLSHLVKLIVQRSRLVQKESSSAPNEISSARDQTDTVEKKRATTTSPLPPLPIPELRAIINRHLSYLRAFATDQEFQETVRFASDFQTPGSIGRRLYDRLQVMKAANPDTWYHDLYLQNQYLVRNGPLAPYMTFFFTHPVNIGRHSQAERAALIASTVIRYKFCLENGQIQPRLVNEQPQCMDLYKYMFNTVREPTLGVDLMSRYPGNDYFVVLRRGHVYKVEFDSSAQHAQYERLERIFQTILDTRIDEVDWLGVLTTADRISWAKTRHEFMHLSEENASYIRTIEQSAFVVCLDDGSPETPEERGRHFHFLDGSNRWHDKPIEFIIAANGASGVLGDHTGLDAGTVHELNTEIAEAIRRHQDRRTLSNGTSCEVTVHPVRYSAISPGIEARIHETRSIYTAAISSREHRYTTWTGYGSSLMKAYKIPANSAFQLVVQLAGRYYFGQTSPCWETVLQSNFHTGRVEINQVVTAQVAAFVDAAAEAVPLSDCRQLLLEAARAHSSAVLACTRAGGSDRFLSMMREIVEADEQEPELYHDPVYKRARPRKFISNCFTTGMAENGCCLREDDGIWLHFEVEPESVKYSILGPAGDTTRFCDSLARAAEKVWDILQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>C8V5Y2</accession>
    <name>C8V5Y2_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_11421</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF74991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467393.1">
        <property type="nucleotide sequence ID" value="XM_050611358.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V5Y2"/>
    <dbReference type="GeneID" id="74897009"/>
    <dbReference type="KEGG" id="ani:ANIA_11421"/>
    <dbReference type="HOGENOM" id="CLU_2904178_0_0_1"/>
    <dbReference type="InParanoid" id="C8V5Y2"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF74991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="62" mass="6820" checksum="F02F721FE9543D71" modified="2009-11-03" version="1">MPGEGMLVTNPMLKGVNLNTEGDMAREEGKDADMGDARRELIYNWESLHISNKGTHGDLTDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>C8V7Z2</accession>
    <name>C8V7Z2_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">ATP synthase subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">ANIA_10626</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="17">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF76119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467554.1">
        <property type="nucleotide sequence ID" value="XM_050611536.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V7Z2"/>
    <dbReference type="STRING" id="227321.C8V7Z2"/>
    <dbReference type="GeneID" id="74896513"/>
    <dbReference type="KEGG" id="ani:ANIA_10626"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN10626"/>
    <dbReference type="eggNOG" id="KOG1353">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010091_2_1_1"/>
    <dbReference type="InParanoid" id="C8V7Z2"/>
    <dbReference type="OMA" id="YCGVKGY"/>
    <dbReference type="OrthoDB" id="9805536at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd18113">
        <property type="entry name" value="ATP-synt_F1_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18116">
        <property type="entry name" value="ATP-synt_F1_alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01132">
        <property type="entry name" value="F1-ATPase_alpha_CD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.150.20:FF:000001">
        <property type="entry name" value="ATP synthase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.20:FF:000001">
        <property type="entry name" value="ATP synthase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:004039">
        <property type="entry name" value="ATP synthase subunit alpha, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.150.20">
        <property type="entry name" value="ATP synthase alpha/beta chain, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01346">
        <property type="entry name" value="ATP_synth_alpha_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000793">
        <property type="entry name" value="ATP_synth_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038376">
        <property type="entry name" value="ATP_synth_asu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033732">
        <property type="entry name" value="ATP_synth_F1_a_nt-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005294">
        <property type="entry name" value="ATP_synth_F1_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00962">
        <property type="entry name" value="atpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009884">
        <property type="entry name" value="PRK13343.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48082">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48082:SF2">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00306">
        <property type="entry name" value="ATP-synt_ab_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039088">
        <property type="entry name" value="F_ATPase_subunit_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47917">
        <property type="entry name" value="C-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="N-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="6 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 12" id="KW-0139">CF(1)</keyword>
    <keyword evidence="5 11" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit N-terminal" evidence="15">
        <location>
            <begin position="78"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding" evidence="13">
        <location>
            <begin position="201"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="ATP synthase alpha subunit C-terminal" evidence="14">
        <location>
            <begin position="431"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CBF76119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="561" mass="61475" checksum="22B83B6CC2CD5323" modified="2009-11-03" version="1">MPENYLIMSKSTWQSLNRLATATLIPRRGRSTSNPTSSLAILWKQPFSSGRCVKCPSGEISSLLEQRIRGLKGSPNLAESGHVLSVCDGIVRARGLTNVQAEELVEFESGVKGMCMNLESNHVGIVLFGSDRLVKQSEPVWRTGEIVDVPVGPKMLGRVVDALGNPIDGKGPIETTERSRAQIKAPGILPRRSVNQPVQTGLKAIDAMVPIGRGQRELIIGDRQTGKTAIALDTILNQKIWNKSDDESKKLYCVYVAVGQKRSTVAQLVKTLEENDAMKYSIVVAATASEAAPLQYIAPFAGCAMGEWFRDHGRHAIIIYDDLSKHAVAYRQMSLLLRRPPGREAYPGDVFYLHSRLLERAAKLNDKHGGGSLTALPIIETQGGDVSAYIPTNVISITDGQIYLESELFNRGIRPAINVGLSVSRVGSAAQVRAMKQVAGSLKLYLAQYREIAAFSQFGSDLDAATKQTLRRGEHLTELLKQKQYAPMAVNEMVPLLYAGINGLIDRIPIGQIQSWEADVLAHFKSYEPEVLAQIEKDGKLSHDLEARIKEIIIAFNAAFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>C8V9R9</accession>
    <name>C8V9R9_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ANIA_11121</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF78054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467792.1">
        <property type="nucleotide sequence ID" value="XM_050611808.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V9R9"/>
    <dbReference type="GeneID" id="74896792"/>
    <dbReference type="KEGG" id="ani:ANIA_11121"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN11121"/>
    <dbReference type="eggNOG" id="ENOG502QXCY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013364_3_1_1"/>
    <dbReference type="InParanoid" id="C8V9R9"/>
    <dbReference type="OMA" id="LNCAYWP"/>
    <dbReference type="OrthoDB" id="425534at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013595">
        <property type="entry name" value="Pept_S33_TAP-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051601">
        <property type="entry name" value="Serine_prot/Carboxylest_S33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248">
        <property type="entry name" value="2-SUCCINYL-6-HYDROXY-2,4-CYCLOHEXADIENE-1-CARBOXYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248:SF30">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08386">
        <property type="entry name" value="Abhydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="134"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S33 tripeptidyl aminopeptidase-like C-terminal" evidence="4">
        <location>
            <begin position="458"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBF78054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="555" mass="59917" checksum="AB4277CDB31F1E1E" modified="2009-11-03" version="1">MTQSDFGAGAYGDRHCSAGGPDLLLLSSLRTLLLAHRSASYHRSKTTMLSLLLLSIASISTASSITWKNCTVANFPGLANLGVDSYIDQIGNASHLDCGELQVPLDWSRPHGENITLGMARYRATLPGKRLGSIIYNPGGPGGPGSISALAQAVGIPYYTNGTKDYYDVIGLDPRGIGLSTRVKCDPDLYNKRVSLFPTTEEEFHALVEKNRALGESCRNLTGELFYHVDTTSAARDLEAVRIALGDEKLNWIGLSYGTQLGGAYAELYPESVGRMVLDGNLDHSQSETGALQTEVSTYEDVLNQFFKWCNTTATDDECPLKGQDLPQIFDDLVAAANESPIEAPGCAGDQSACRSTVTGQDILINAQPYLVYERAQSKRSSANWPTLAQYLNNTIAGDATGFSSSLATSERDLSYPDIAIGCLDWRHDSTSLSDILYKLQLSSYLAPHTKGASQSYRYQVSCIGWPAPLVNPPHKLNQTSMAKAPPILMVNAFHDPETSYVWANNLLEQIPSGVLLTRDGNGHTSYSLGGEASVLIDAFLVNGTLPRRNTVVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>C8VAZ9</accession>
    <name>C8VAZ9_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_10587</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF77014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467667.1">
        <property type="nucleotide sequence ID" value="XM_050611664.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VAZ9"/>
    <dbReference type="GeneID" id="74896487"/>
    <dbReference type="KEGG" id="ani:ANIA_10587"/>
    <dbReference type="HOGENOM" id="CLU_1777417_0_0_1"/>
    <dbReference type="InParanoid" id="C8VAZ9"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF77014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="146" mass="15945" checksum="398A3C85CFCAD721" modified="2009-11-03" version="1">MRVAAWAFIRHVEMVANQGFSPPGPSVSLGSSLGSCTLIGTLFDRIPTRACFLSGCGICKNLTTGLGLAGLRFSSVRARLQMTSTSHPFFWFTAISVFPFRVSWSSLVIITSAIHYSQRRSPRTTLANTLYTHTAYLDRAVDGPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2025-10-08" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>C8VBB9</accession>
    <name>C8VBB9_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Heterogeneous nuclear ribonucleoprotein HRP1 (AFU_orthologue AFUA_2G06090)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ANIA_10941</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF79395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="XP_680715.2">
        <property type="nucleotide sequence ID" value="XM_675623.2"/>
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    <dbReference type="AlphaFoldDB" id="C8VBB9"/>
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    <dbReference type="STRING" id="227321.C8VBB9"/>
    <dbReference type="GeneID" id="2869561"/>
    <dbReference type="KEGG" id="ani:ANIA_10941"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN10941"/>
    <dbReference type="eggNOG" id="KOG4205">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="InParanoid" id="C8VBB9"/>
    <dbReference type="OMA" id="AMPNMMN"/>
    <dbReference type="OrthoDB" id="1875751at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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        <property type="entry name" value="RRM1_Hrp1p"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RRM2_Hrp1p"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Heterogeneous nuclear ribonucleoprotein HRP1"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="3.30.70.330:FF:000025">
        <property type="entry name" value="RNA-binding protein Musashi homolog 2 isoform X1"/>
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        <property type="match status" value="2"/>
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        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
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        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48031:SF2">
        <property type="entry name" value="RNA-BINDING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48031">
        <property type="entry name" value="SRA STEM-LOOP-INTERACTING RNA-BINDING PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="110"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="194"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="269"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
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            <begin position="369"/>
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        </location>
    </feature>
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        <location>
            <begin position="476"/>
            <end position="559"/>
        </location>
    </feature>
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            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
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            <begin position="23"/>
            <end position="51"/>
        </location>
    </feature>
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            <begin position="61"/>
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            <begin position="81"/>
            <end position="94"/>
        </location>
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            <begin position="269"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
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            <end position="381"/>
        </location>
    </feature>
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            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="513"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBF79395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="559" mass="59993" checksum="5C448A5CBECCB2B0" modified="2009-11-03" version="1">MAEPEDVEEDLFADLYDADETGNQAASTGGAPAASNSAPSDAPAQPSATSAIQSVEGVGNESETTHGTYQTPTYEGGYQNGSGPDSGYNNQTTGPVGEPEPQGTGIKEDGKMFIGGLNWETTDQSLKEYFSQFGEVQECTVMRDSATGRSRGFGFLTFKDPKTVNTVMVKEHYLDGKIIDPKRAIPRDEQEKTSKIFVGGVSQEATEQDFKQFFMQFGRVIDATLMIDKDTGRPRGFGFVTFDSEAAVEAALSRPLEILGKTIEVKKAQPRGNLRDDGDRGRRGRDFRDGSQGGSDGSQQQAGAQGQGVMPGGLTPQMMAQYWQRMQQYFALMQQQMAVAATQGQGMGAMGMAGMNPALMQQMQMKQLQQMQMGNNQQSPSMSPPAQSPTPQSMQNMMNPAMMQQMQQQMPNQGQANNMGGQMGMGGNGSGNMNMGSNYAGGGRGGPGYNAHEQIAFEQQKYEQQQARRAMENRAFSPYQQGGPTSWEGMYDEVPQPNIPTGPQAMNRSSSVGRGQTPQPQGAAPANAPTGPKNAGKPGANYRGGGRGGHRGFHPYARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>C8VBF8</accession>
    <name>C8VBF8_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_07482</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF79465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_680751.2">
        <property type="nucleotide sequence ID" value="XM_675659.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VBF8"/>
    <dbReference type="STRING" id="227321.C8VBF8"/>
    <dbReference type="GeneID" id="2869501"/>
    <dbReference type="KEGG" id="ani:ANIA_07482"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN7482"/>
    <dbReference type="eggNOG" id="ENOG502T2BP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065832_0_0_1"/>
    <dbReference type="InParanoid" id="C8VBF8"/>
    <dbReference type="OMA" id="NVWYPWM"/>
    <dbReference type="OrthoDB" id="3921745at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="115"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF79465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="277" mass="32117" checksum="A3C9ACA6A6B8AA8B" modified="2009-11-03" version="1">MTELSPRPSRSMAIDSLLNPQGEAEKAGSISLPSMHYGAGSGPLTPHSQYPPYYPRSPTHYFHGSENQHHHRNHHHHYNPYQHSHSQIQDHRDPYASYHHSTNSSPEPYSRDRYSSVSSSTSSSNGHHSHHSHSNGTSVSGSGGGREGRRQPRPKYEEEEMYFIWYQRVDLGQEWKEVRESFNRQFPERPRKGFQGIQCKFYRFIKEKKCPTLREQRRMRDGEFVSGQAPHALSHPSSDSASGYGGKPQFGVVEWMGVWYPWMRENQEEVMRKRLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C8VC44</accession>
    <name>C8VC44_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dioxygenase, putative (AFU_orthologue AFUA_8G07350)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_11002</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF79900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468019.1">
        <property type="nucleotide sequence ID" value="XM_050612060.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VC44"/>
    <dbReference type="GeneID" id="74896725"/>
    <dbReference type="KEGG" id="ani:ANIA_11002"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN11002"/>
    <dbReference type="eggNOG" id="ENOG502QUGY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071636_0_0_1"/>
    <dbReference type="InParanoid" id="C8VC44"/>
    <dbReference type="OMA" id="DFFRYVG"/>
    <dbReference type="OrthoDB" id="2588190at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02215">
        <property type="entry name" value="cupin_QDO_N_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053146">
        <property type="entry name" value="QDO-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36440">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_8G07350)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36440:SF1">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_8G07350)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin type-2" evidence="1">
        <location>
            <begin position="62"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF79900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="355" mass="39059" checksum="DD7E31EC42FBD052" modified="2009-11-03" version="1">MSSSLWTPTPPPSRTPYAIPQLEGERLTIPGSKGTFRILASSKQTNGLMAVFQSGATLSDAPGFHYHNHAHDVFLVTKGYLKLWNGDKCRIMGPGDFAYVPPAVVHNPELLGPHTETFGVVTPGDWIDFFRYISEPYTGILVPEADDRDLKALLIPKVMAAKGQFDVVFQPNYVPPQVGDWDADDEKLPEGESPAPYYLRANTGPRWMLGSVMSRPFITTKQCAGVCAISSIESSNVYGASSSVLSRFMTFEKVDHCLAVMEGTLVVRLKGQEQREEVFREGETVVIPAGQAFALEFRSKYVRVWSFTDGDGIESLIQRAGKAVSRVVLPETVEGLDVDEGRVDKVAKELSLTLE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-11-16" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C8VCL5</accession>
    <accession>Q5AWJ3</accession>
    <name>Y0929_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Rhomboid-type serine protease 2</fullName>
            <ecNumber evidence="1">3.4.21.105</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Rhomboid protein 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Uncharacterized rhomboid protein AN10929</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="ORF">AN10929</name>
    </gene>
    <organism>
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Probable rhomboid-type serine protease that catalyzes intramembrane proteolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleaves type-1 transmembrane domains using a catalytic dyad composed of serine and histidine that are contributed by different transmembrane domains.</text>
            <dbReference type="EC" id="3.4.21.105"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase S54 family.</text>
    </comment>
    <comment type="sequence caution" evidence="4">
        <conflict type="erroneous gene model prediction">
            <sequence resource="EMBL-CDS" id="EAA61708" version="1"/>
        </conflict>
        <text>The predicted gene AN7337 has been split into 2 genes: AN10929 and AN10934.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.105" evidence="1"/>
    <dbReference type="EMBL" id="AACD01000128">
        <property type="protein sequence ID" value="EAA61708.1"/>
        <property type="status" value="ALT_SEQ"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF78591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VCL5"/>
    <dbReference type="SMR" id="C8VCL5"/>
    <dbReference type="STRING" id="227321.C8VCL5"/>
    <dbReference type="EnsemblFungi" id="CBF78591">
        <property type="protein sequence ID" value="CBF78591"/>
        <property type="gene ID" value="ANIA_10929"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AN10929"/>
    <dbReference type="eggNOG" id="KOG2289">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010291_0_0_1"/>
    <dbReference type="InParanoid" id="C8VCL5"/>
    <dbReference type="OMA" id="PIMIKPQ"/>
    <dbReference type="OrthoDB" id="2146116at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002610">
        <property type="entry name" value="Peptidase_S54_rhomboid-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22936:SF69">
        <property type="entry name" value="RHOMBOID-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22936">
        <property type="entry name" value="RHOMBOID-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0645">Protease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0720">Serine protease</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000413956" description="Rhomboid-type serine protease 2">
        <location>
            <begin position="1"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="2">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="topological domain" description="Extracellular" evidence="2">
        <location>
            <begin position="158"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="254"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="2">
        <location>
            <begin position="275"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="284"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="topological domain" description="Extracellular" evidence="2">
        <location>
            <begin position="305"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="317"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="2">
        <location>
            <begin position="338"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="343"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="topological domain" description="Extracellular" evidence="2">
        <location>
            <begin position="364"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="366"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="2">
        <location>
            <begin position="387"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="450"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="topological domain" description="Extracellular" evidence="2">
        <location>
            <begin position="471"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="319"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="O74926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="503" mass="55450" checksum="514C0479D6FEA94B" modified="2009-11-03" version="1">MAAQSYYNGAYNSPPAYEQHDHTSDQFNRVSPRPSPSPVAYNNAPYYQSDDPHDPNSLRYSQQSIGSDNGAYVAGGRINEHDQYAENIPLKSANPYGNDHPPQPWMQQPTHYAPDPGMMEPQVPMRQKKKGFFQKKIAYVTYILTIAQIIVFIVELVKMGQLTGSPIQTKPQFNPMVGPSAYVQINMGARYTPCMKNVPGVQNATQQVLFPCPNATTTDSDCSLSELCGFDGVPNPHPGGSLDDKPAPDQWFRFIIPMFLHSGFVHIGFNLLVQMTMGADMERMIGWWRYGLVYLSSGIWGFVLGGNYAGQGEASCGCSGALFGILALFVLDLLYGWNDRQNPWVELIIMVLGIAVSFVLGLLPGLDNFSHLGGFTMGLALGLCVMRSPNALRERIGLARSPYVAMSGGVAAENADPDQNKTSTGSNIGGLGKFNPKGFFAGRKPLWWAWWLVRLGALVAVLIGFILLIVNFYKYPSSNCSWCYRFSCLPVNGWCDQGNLFSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>C8VE29</accession>
    <name>C8VE29_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ANIA_11601</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF80335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468068.1">
        <property type="nucleotide sequence ID" value="XM_050612114.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VE29"/>
    <dbReference type="GeneID" id="74897162"/>
    <dbReference type="KEGG" id="ani:ANIA_11601"/>
    <dbReference type="HOGENOM" id="CLU_2454729_0_0_1"/>
    <dbReference type="InParanoid" id="C8VE29"/>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF80335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="89" mass="10133" checksum="255FA4FC07CE4E38" modified="2009-11-03" version="1">MRNGFDRSPSVIRRWGSLLAAYHTTSPLATLVKLGVLYVKKNQSIFWSIEATLCGLDCSMFLENASLYEGNNAGYESNRPRKMWSRLDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>C8VFI2</accession>
    <name>C8VFI2_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_10726</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF81267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468196.1">
        <property type="nucleotide sequence ID" value="XM_050612254.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VFI2"/>
    <dbReference type="GeneID" id="74896566"/>
    <dbReference type="KEGG" id="ani:ANIA_10726"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN10726"/>
    <dbReference type="HOGENOM" id="CLU_2512620_0_0_1"/>
    <dbReference type="InParanoid" id="C8VFI2"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF81267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="85" mass="9667" checksum="AD45E82EEAC3DC14" modified="2009-11-03" version="1">MIWPPETQGSPQTWRPHEPRFRRQQHNFDPAIPVPSSMLPICHQHCVDIISGQASVFLLGDSATNVQPSTRTRTKKEEPSEPPQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>C8VFU1</accession>
    <name>C8VFU1_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">5'-nucleotidase, putative (AFU_orthologue AFUA_1G01160)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ANIA_05655</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the 5'-nucleotidase family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF81468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468218.1">
        <property type="nucleotide sequence ID" value="XM_050612277.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VFU1"/>
    <dbReference type="STRING" id="227321.C8VFU1"/>
    <dbReference type="GeneID" id="2871939"/>
    <dbReference type="KEGG" id="ani:ANIA_05655"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN5655"/>
    <dbReference type="eggNOG" id="KOG4419">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005854_7_2_1"/>
    <dbReference type="InParanoid" id="C8VFU1"/>
    <dbReference type="OMA" id="YTIAMVS"/>
    <dbReference type="OrthoDB" id="10252235at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.780.10">
        <property type="entry name" value="5'-Nucleotidase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008334">
        <property type="entry name" value="5'-Nucleotdase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036907">
        <property type="entry name" value="5'-Nucleotdase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006179">
        <property type="entry name" value="5_nucleotidase/apyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575">
        <property type="entry name" value="5'-NUCLEOTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575:SF41">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G01160)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02872">
        <property type="entry name" value="5_nucleotid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01607">
        <property type="entry name" value="APYRASEFAMLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55816">
        <property type="entry name" value="5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="5'-Nucleotidase C-terminal" evidence="3">
        <location>
            <begin position="276"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBF81468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="498" mass="55056" checksum="F5919FF2F6287FB6" modified="2009-11-03" version="1">MTVEMRIDEVQFVHFNDVREFAVSNPASQTLTLFSGDAFSPSLEASVLKGAQVCPFLNLVGVDIGCYGNHDFDFGDARLIELSSQLKFPWLLSNAYHLQKNQRRTLGSAREYIVRNLENGLKVGFIGLAGTDWPSNCELLPPCEFEPPVQAARRLARHLRVQERCDLVVALTHMRVPEDMAVANATVSGDSRIDLLLGGHDHDVLRRGKYKARKKRDRLERLVAGTVDCATSREWNRSSINSEPPTHVVETLQAIHDQVGKLVQRPLLHAATPIDGRNAMIRSQETNMGNMLADAVRAFYDADIGFFNSGAVRSDCILGAADPDGEPLLVRDIINICPFGNSVLVKKMPGSIIRLALENSVSDMHTDGRFLQVSGLRVVASWHQPEWSRVVDVFFQRSDGSLEPLDPDRTYTVAMPSFIARGYDGFSWFAQLETLVGEEAAVTDAGLLLAIFGHEQSSDGDMHAIGIERARAVTIVGQNPTDSLPIVKPVVEDRIKFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>C8VGD6</accession>
    <name>C8VGD6_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GTP-binding nuclear protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ANIA_05482</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the small GTPase superfamily. Ran family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF81826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468261.1">
        <property type="nucleotide sequence ID" value="XM_050612324.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VGD6"/>
    <dbReference type="SMR" id="C8VGD6"/>
    <dbReference type="FunCoup" id="C8VGD6">
        <property type="interactions" value="1427"/>
    </dbReference>
    <dbReference type="STRING" id="227321.C8VGD6"/>
    <dbReference type="GeneID" id="2871768"/>
    <dbReference type="KEGG" id="ani:ANIA_05482"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN5482"/>
    <dbReference type="eggNOG" id="KOG0096">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041217_13_0_1"/>
    <dbReference type="InParanoid" id="C8VGD6"/>
    <dbReference type="OMA" id="FNAWDTA"/>
    <dbReference type="OrthoDB" id="48625at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000054">
        <property type="term" value="P:ribosomal subunit export from nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00877">
        <property type="entry name" value="Ran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000131">
        <property type="entry name" value="GTP-binding nuclear protein Ran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002041">
        <property type="entry name" value="Ran_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24071:SF0">
        <property type="entry name" value="GTP-BINDING NUCLEAR PROTEIN RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24071">
        <property type="entry name" value="RAN GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00627">
        <property type="entry name" value="GTPRANTC4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51418">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBF81826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="215" mass="24177" checksum="3CE19DAE07165F0C" modified="2009-11-03" version="1">MAEQQVPTFKLVLVGDGGTGKTTFVKRHLTGEFEKKYIATLGVEVHPIKFTTNLGTIQFDVWDTAGQEKFGGLRDGYYINGQCGIIMFDVTSRITYKNVPNWHRDLVRVCENIPIVLCGNKVDVKERKVKAKTITFHRKKNLQYYDISAKSNYNFEKPFLWLARKLVGNASLEFVAAPALAPPEVQVDATLMQQYSDEMAAAANQPLPDEDDADL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C8VHD1</accession>
    <name>C8VHD1_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Integral membrane protein, putative (AFU_orthologue AFUA_3G05690)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ANIA_03439</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the unc-50 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF82709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468376.1">
        <property type="nucleotide sequence ID" value="XM_050612454.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VHD1"/>
    <dbReference type="FunCoup" id="C8VHD1">
        <property type="interactions" value="628"/>
    </dbReference>
    <dbReference type="STRING" id="227321.C8VHD1"/>
    <dbReference type="GeneID" id="2874168"/>
    <dbReference type="KEGG" id="ani:ANIA_03439"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN3439"/>
    <dbReference type="eggNOG" id="KOG3012">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066239_1_2_1"/>
    <dbReference type="InParanoid" id="C8VHD1"/>
    <dbReference type="OMA" id="YRNFMYR"/>
    <dbReference type="OrthoDB" id="10027013at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007881">
        <property type="entry name" value="UNC-50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12841">
        <property type="entry name" value="PROTEIN UNC-50 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12841:SF6">
        <property type="entry name" value="PROTEIN UNC-50 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05216">
        <property type="entry name" value="UNC-50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="114"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="214"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="251"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBF82709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="286" mass="32548" checksum="810F80B1DAB58180" modified="2009-11-03" version="1">MNPHISVPRQHGSSPNFGGLPANRGSSTIRMPRFFKRMFKFPQMDFEMAIWEMTSLMIAPKKVFKSIYYHKQTKNTWHRPDPSFAYLLSFFLLLTALAWGLAYAPSFGSIMRLFFRFVVVHFIGSSLLVSTIGYFAIGRLFGPNGAAASITGLRIRGRRRGAAQGLFTQPGEKDQLEFGYCFDVSNRAFFPLYLHLYVVQFLLLPLLTRSPSDFLTTFLGNTLYLSAFTYYTYITFLGYNALPFLHNTELLLLPILLFAILWLVSLIVGWGVVMQGHSVKGLFWGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>C8VIZ5</accession>
    <name>C8VIZ5_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_02979</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF83628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468480.1">
        <property type="nucleotide sequence ID" value="XM_050612571.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VIZ5"/>
    <dbReference type="GeneID" id="2874289"/>
    <dbReference type="KEGG" id="ani:ANIA_02979"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN2979"/>
    <dbReference type="eggNOG" id="ENOG502RXHE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037541_0_0_1"/>
    <dbReference type="InParanoid" id="C8VIZ5"/>
    <dbReference type="OMA" id="RFPQDSY"/>
    <dbReference type="OrthoDB" id="5330253at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018809">
        <property type="entry name" value="DUF2406"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28186">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 9 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28186:SF1">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 9 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10295">
        <property type="entry name" value="DUF2406"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="146"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="177"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="216"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="274"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="370"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF83628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="382" mass="42293" checksum="8750F077E0FE0613" modified="2009-11-03" version="1">MVSPQPTSPTPSKRSRGFSSSGRSDRSEKTHRSSGSGHKISLTETSEEKHRRSLQTKADPMLAINEAQPNLVALEKSNLGSLRAMQHKDQYGNIITDPDLSNPTRPRFERPLDTIRSFEAAIYGQYTSRPASYAQTGEDGGDYSRRSSYYNPYSNGQTRQHNDRGYYNGRPSHSRPNSYMDNGNGYYNSGGPPESYYPYNQNGGRRPRQYPRGHSEQPSYSSQQSGYNQNSYAQSGYFKSSDNVTVATPSGSGSTPDQWANSTDPSSINSSFDQFQQQQQQQQQERTIADNYGFQGFGAGPNINDETFAPNVAGKAPYGQDFAAQPAHDPNFGGPVGGPQNPQLVAGRRHLQRKSQQQSVSSDAGDNGTKRKSWFKRTFTKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>C8VJC6</accession>
    <name>C8VJC6_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD binding Rossmann fold oxidoreductase, putative (AFU_orthologue AFUA_3G11930)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_02858</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF83862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_660462.2">
        <property type="nucleotide sequence ID" value="XM_655370.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VJC6"/>
    <dbReference type="STRING" id="227321.C8VJC6"/>
    <dbReference type="GeneID" id="2873845"/>
    <dbReference type="KEGG" id="ani:ANIA_02858"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN2858"/>
    <dbReference type="eggNOG" id="ENOG502QUH1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039854_1_0_1"/>
    <dbReference type="InParanoid" id="C8VJC6"/>
    <dbReference type="OMA" id="FFNAWMS"/>
    <dbReference type="OrthoDB" id="2127032at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006740">
        <property type="term" value="P:NADPH regeneration"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000030">
        <property type="entry name" value="NAD binding Rossmann fold oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000778">
        <property type="entry name" value="NAD binding Rossmann fold oxidoreductase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42840:SF6">
        <property type="entry name" value="BINDING ROSSMANN FOLD OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42840">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="1">
        <location>
            <begin position="88"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF83862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="414" mass="45608" checksum="1D203C3780ED81DD" modified="2009-11-03" version="1">MAPPSVLMVGTGEYTTGYVGGGASGSDKKVGVVGLTLFDLRRRGKVGDLSMVGVSGRKFPGIREHLHKNITQVYNNLDTSFTSYPADDATDPDAYKAAIDALPKGSAITIFTPDPTHFSIALYAIERGIHVLVTKPAVKTLPEHIALLEAAQKHNVFVFVEHHKRFDPAYSDARAKAKNLGDFNYFYSYMSQPKFQLETFKAWAGKESDISYYLNSHHVDICDSMVGNDYTPVRVNASASKGTAVELGCVPETEDTITLLVDWKHKTQPGKVATGVYTASWTAPQKAGVHSNQYFHYMGATGEIRVNQAKRGYDVTGDDSGLAWINPFYMRYAPDEEGNFGGQTGYGYISFEKFIDAITALNEGRVTLKELDNRPLPTLKNTIATTAILHAGRVSLDEKRAVEIFEKDGKWELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>C8VJG6</accession>
    <name>C8VJG6_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Mannan endo-1,6-alpha-mannosidase</fullName>
            <ecNumber evidence="4 10">3.2.1.101</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">ANIA_10345</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Random hydrolysis of (1-&gt;6)-alpha-D-mannosidic linkages in unbranched (1-&gt;6)-mannans.</text>
            <dbReference type="EC" id="3.2.1.101"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyl hydrolase 76 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.101" evidence="4 10"/>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF83933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468528.1">
        <property type="nucleotide sequence ID" value="XM_050612627.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VJG6"/>
    <dbReference type="FunCoup" id="C8VJG6">
        <property type="interactions" value="25"/>
    </dbReference>
    <dbReference type="STRING" id="227321.C8VJG6"/>
    <dbReference type="GeneID" id="74896351"/>
    <dbReference type="KEGG" id="ani:ANIA_10345"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN10345"/>
    <dbReference type="eggNOG" id="ENOG502QSWP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025694_1_2_1"/>
    <dbReference type="InParanoid" id="C8VJG6"/>
    <dbReference type="OMA" id="GMFQPPY"/>
    <dbReference type="OrthoDB" id="4187847at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008496">
        <property type="term" value="F:mannan endo-1,6-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000006">
        <property type="entry name" value="Mannan endo-1,6-alpha-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005198">
        <property type="entry name" value="Glyco_hydro_76"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014480">
        <property type="entry name" value="Mannan-1_6-alpha_mannosidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12145">
        <property type="entry name" value="MANNAN ENDO-1,6-ALPHA-MANNOSIDASE DCW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12145:SF36">
        <property type="entry name" value="MANNAN ENDO-1,6-ALPHA-MANNOSIDASE DCW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03663">
        <property type="entry name" value="Glyco_hydro_76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016302">
        <property type="entry name" value="Man_a_manosd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002992215" description="Mannan endo-1,6-alpha-mannosidase" evidence="11">
        <location>
            <begin position="18"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR016302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CBF83933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="462" mass="51250" checksum="F2635405509A90DD" modified="2009-11-03" version="1">MKILWNLLLIFLIPVQGVELDLDNTVSVKKACYAIAKNMLSHYTGYKPGDVPGNLPDPYYWWEAGAMFNALIDYWFYTGDSRWNNITSQALIWQAGESGSFMPANQTRTEGNDDQGFWAFAAMSAAERNFPMPRDKHETPGPDWLAMAQATFNTQAWRWDAQNCGGGLRWQIFTWNAGYMYKNTISNGCFFNLAARLARYTGNQTYADWATKVWNWTHAVGFMTDDYSFYDGASIDGNCTNFDHVQWTYNAGVYLLGAAAMYNYTNGDPLWKQRTEGIINAAHIFFADSPSSKDIMYERACESINTCKVDQRAFKGFLARWMAQSTQFAPFTYDMVMPKLRSSALAAAKTCTGGSDGAECSLKWTEQKYTGGPAGGDVGIQMAALEVLQSTLIQKVEPPVTRKEGGLSMGDPAGGSEPPVPTPALLVREIETGDRVGAALVTIFMAGCIVWSVKWAVHDPGT</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2016-11-02" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C8VJQ1</accession>
    <accession>Q5AR51</accession>
    <name>ASQH1_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Prenyltransferase asqH1</fullName>
            <ecNumber evidence="6">2.5.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">4'-methoxyviridicatin/aspoquinolone biosynthesis cluster protein asqH1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Aspoquinolone biosynthesis protein H1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">asqH1</name>
        <name type="ORF">AN9229</name>
        <name type="ORF">ANIA_11194</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2014" name="Angew. Chem. Int. Ed." volume="53" first="12880" last="12884">
            <title>Non-heme dioxygenase catalyzes atypical oxidations of 6,7-bicyclic systems to form the 6,6-quinolone core of viridicatin-type fungal alkaloids.</title>
            <authorList>
                <person name="Ishikawa N."/>
                <person name="Tanaka H."/>
                <person name="Koyama F."/>
                <person name="Noguchi H."/>
                <person name="Wang C.C."/>
                <person name="Hotta K."/>
                <person name="Watanabe K."/>
            </authorList>
            <dbReference type="PubMed" id="25251934"/>
            <dbReference type="DOI" id="10.1002/anie.201407920"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>PATHWAY</scope>
    </reference>
    <comment type="function">
        <text evidence="1 4 5">Prenyltransferase; part of the gene cluster that mediates the biosynthesis of the aspoquinolone mycotoxins (PubMed:25251934). Within the pathway, the prenyltransferase asqH1 catalyzes the canonical Friedel-Crafts alkylation of quinolinone B with dimethylallyl cation to yield dimethylallyl quinolone (By similarity). The first step of the pathway is catalyzed by the nonribosomal peptide synthetase asqK that condenses anthranilic acid and O-methyl-L-tyrosine to produce 4'-methoxycyclopeptin. 4'-methoxycyclopeptin is then converted to 4'-methoxydehydrocyclopeptin by the ketoglutarate-dependent dioxygenase asqJ. AsqJ also converts its first product 4'-methoxydehydrocyclopeptin to 4'-methoxycyclopenin. The following conversion of 4'-methoxycyclopenin into 4'-methoxyviridicatin is catalyzed by the cyclopenase asqI. 4'-methoxyviridicatin is the precursor of quinolone natural products, and is further converted to quinolinone B. The prenyltransferase asqH1 then catalyzes the canonical Friedel-Crafts alkylation of quinolinone B with dimethylallyl cation to yield dimethylallyl quinolone, which is subjected to FAD-dependent dehydrogenation by the FAD-linked oxidoreductase asqF to yield conjugated aryl diene. The delta(3') double bond then serves as the site of the second alkylation with DMAPP catalyzed by the prenyltransferase asqH2 to yield a carbenium ion intermediate, which can be attacked by H(2)O to yield a styrenyl quinolone containing a C3'-hydroxyprenyl chain. The FAD-dependent monooxygenase asqG performs epoxidation of the terminal C7'-C8' olefin. Finally, after dehydratation of the epoxide at C3 by asqC, the quinolone epoxide rearrangement protein asqO catalyzes an enzymatic 3-exo-tet cyclization to yield the cyclopropyl-THF ring system in aspoquinolone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>quinolinone B + dimethylallyl diphosphate = peniprequinolone + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:73999"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
            <dbReference type="ChEBI" id="CHEBI:181572"/>
            <dbReference type="ChEBI" id="CHEBI:182576"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:74000"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Alkaloid biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the tryptophan dimethylallyltransferase family.</text>
    </comment>
    <comment type="sequence caution" evidence="5">
        <conflict type="erroneous gene model prediction">
            <sequence resource="EMBL-CDS" id="EAA61520" version="1"/>
        </conflict>
        <text>The predicted gene AN9229 has been split into 2 genes: ANIA_11194 and ANIA_1120.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.-" evidence="6"/>
    <dbReference type="EMBL" id="AACD01000170">
        <property type="protein sequence ID" value="EAA61520.1"/>
        <property type="status" value="ALT_SEQ"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF82275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VJQ1"/>
    <dbReference type="SMR" id="C8VJQ1"/>
    <dbReference type="EnsemblFungi" id="CBF82275">
        <property type="protein sequence ID" value="CBF82275"/>
        <property type="gene ID" value="ANIA_11194"/>
    </dbReference>
    <dbReference type="GeneID" id="2868058"/>
    <dbReference type="KEGG" id="ani:ANIA_11194"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN11194"/>
    <dbReference type="eggNOG" id="ENOG502S2XP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037431_2_0_1"/>
    <dbReference type="InParanoid" id="C8VJQ1"/>
    <dbReference type="OMA" id="AIMELWE"/>
    <dbReference type="OrthoDB" id="3354387at2759"/>
    <dbReference type="BioCyc" id="MetaCyc:MONOMER-124177"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009821">
        <property type="term" value="P:alkaloid biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd13929">
        <property type="entry name" value="PT-DMATS_CymD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012148">
        <property type="entry name" value="ABBA_DMATS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017795">
        <property type="entry name" value="ABBA_NscD-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03429">
        <property type="entry name" value="arom_pren_DMATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40627">
        <property type="entry name" value="INDOLE PRENYLTRANSFERASE TDIB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40627:SF4">
        <property type="entry name" value="PRENYLTRANSFERASE ASQH1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11991">
        <property type="entry name" value="Trp_DMAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000509">
        <property type="entry name" value="Trp_DMAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000437621" description="Prenyltransferase asqH1">
        <location>
            <begin position="1"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="14"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>L-tryptophan</name>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="373"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="A0A1B2CTB7"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="Q50EL0"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="25251934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <evidence type="ECO:0000305" key="6">
        <source>
            <dbReference type="PubMed" id="25251934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBF82275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="451" mass="50330" checksum="4999D63390F393DA" modified="2009-11-03" version="1">MLCKTGGCVEGRAAEDQSTRKVHWGQEGSGQSPEARPRALDMISRLEPSRGPSHAHWWHIISPQLAVMLEETGYPVEKQLEILTFLYHWVIPYLAPVAAGNAASSCNWKSLLPSAIVPLEYSWKWDSSGKAREPEIRLTIEVFGELSGTQFDPLNQAPAMELLYRLSSILPGVNQILASHFRCKFFDHDNVKYMEEPRLDTLPRSTMLTYMTPRKLGQQGFAPLSEYVSAIQALGQASGRTLDTLTNFLSTSPEGVHLHPFGLAFDNVEPSSSRLKLYFFSNRTSYNSMREVLTLGGRIYSESYDMEEKLRTIYSLAQLLMGCPENNAEDADIPLLPITHSQHTAAERATLLSGFQYYFDVAPGADLPSVKFYIPVRKEHANDRAVGSALTGWFREQGRGKFCDNYMRMLERLAGGLELGECRGLHSFISCMIGGDGEIEVTSYLLPGSEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>C8VQ27</accession>
    <name>C8VQ27_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Small ribosomal subunit protein uS7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ANIA_00843</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS7 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF88674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050469119.1">
        <property type="nucleotide sequence ID" value="XM_050613291.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VQ27"/>
    <dbReference type="FunCoup" id="C8VQ27">
        <property type="interactions" value="1000"/>
    </dbReference>
    <dbReference type="STRING" id="227321.C8VQ27"/>
    <dbReference type="GeneID" id="2876621"/>
    <dbReference type="KEGG" id="ani:ANIA_00843"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN0843"/>
    <dbReference type="eggNOG" id="KOG3291">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063975_0_0_1"/>
    <dbReference type="InParanoid" id="C8VQ27"/>
    <dbReference type="OMA" id="KMNIVER"/>
    <dbReference type="OrthoDB" id="10264639at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0000318"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000054">
        <property type="term" value="P:ribosomal subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd14867">
        <property type="entry name" value="uS7_Eukaryote"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.455.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.455.10">
        <property type="entry name" value="Ribosomal protein S7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000235">
        <property type="entry name" value="Ribosomal_uS7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020606">
        <property type="entry name" value="Ribosomal_uS7_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023798">
        <property type="entry name" value="Ribosomal_uS7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036823">
        <property type="entry name" value="Ribosomal_uS7_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005716">
        <property type="entry name" value="Ribosomal_uS7_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003106">
        <property type="entry name" value="PRK04027.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01028">
        <property type="entry name" value="uS7_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11205">
        <property type="entry name" value="RIBOSOMAL PROTEIN S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00177">
        <property type="entry name" value="Ribosomal_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002122">
        <property type="entry name" value="RPS7p_RPS7a_RPS5e_RPS7o"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47973">
        <property type="entry name" value="Ribosomal protein S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00052">
        <property type="entry name" value="RIBOSOMAL_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS7" evidence="5">
        <location>
            <begin position="56"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBF88674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="215" mass="23910" checksum="C98758C18C61C6E8" modified="2009-11-03" version="1">MSEHGEVEVDIPAGVYDSLPKDALAEMGTVKLFNKWSYEDVEIRDISLTDYIQIRSPVYLPHTAGRYAAKRFRKAQCPIIERLTNSIMMNGRNNGKKLMAVRIVAHAFEIIHIMTDQNPLQVAVDAIVNCGPREDSTRIGSAGTVRRQAVDVSPLRRVNQSIALLTIGAREASFRNIKSIAECLAEELINAAKGSSNSYAIKKKDELERVAKSNR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2016-06-08" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>C8VQ98</accession>
    <name>AUSM_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">FAD-dependent monooxygenase ausM</fullName>
            <ecNumber evidence="9">1.-.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Austinoid biosynthesis clusters protein M</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ausM</name>
        <name type="ORF">AN11206</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2012" name="ACS Chem. Biol." volume="7" first="599" last="606">
            <title>Signaling the induction of sporulation involves the interaction of two secondary metabolites in Aspergillus nidulans.</title>
            <authorList>
                <person name="Rodriguez-Urra A.B."/>
                <person name="Jimenez C."/>
                <person name="Nieto M.I."/>
                <person name="Rodriguez J."/>
                <person name="Hayashi H."/>
                <person name="Ugalde U."/>
            </authorList>
            <dbReference type="PubMed" id="22234162"/>
            <dbReference type="DOI" id="10.1021/cb200455u"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2012" name="J. Am. Chem. Soc." volume="134" first="4709" last="4720">
            <title>Two separate gene clusters encode the biosynthetic pathway for the meroterpenoids austinol and dehydroaustinol in Aspergillus nidulans.</title>
            <authorList>
                <person name="Lo H.C."/>
                <person name="Entwistle R."/>
                <person name="Guo C.J."/>
                <person name="Ahuja M."/>
                <person name="Szewczyk E."/>
                <person name="Hung J.H."/>
                <person name="Chiang Y.M."/>
                <person name="Oakley B.R."/>
                <person name="Wang C.C."/>
            </authorList>
            <dbReference type="PubMed" id="22329759"/>
            <dbReference type="DOI" id="10.1021/ja209809t"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2013" name="J. Am. Chem. Soc." volume="135" first="10962" last="10965">
            <title>Spiro-ring formation is catalyzed by a multifunctional dioxygenase in austinol biosynthesis.</title>
            <authorList>
                <person name="Matsuda Y."/>
                <person name="Awakawa T."/>
                <person name="Wakimoto T."/>
                <person name="Abe I."/>
            </authorList>
            <dbReference type="PubMed" id="23865690"/>
            <dbReference type="DOI" id="10.1021/ja405518u"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2017" name="ACS Chem. Biol." volume="12" first="2927" last="2933">
            <title>Rewiring of the austinoid biosynthetic pathway in filamentous fungi.</title>
            <authorList>
                <person name="Mattern D.J."/>
                <person name="Valiante V."/>
                <person name="Horn F."/>
                <person name="Petzke L."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="29076725"/>
            <dbReference type="DOI" id="10.1021/acschembio.7b00814"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="4 5 6 7">FAD-dependent monooxygenase; part of the gene cluster B that mediates the biosynthesis of austinol and dehydroaustinol, two fungal meroterpenoids (PubMed:22329759). The first step of the pathway is the synthesis of 3,5-dimethylorsellinic acid by the polyketide synthase ausA (PubMed:22329759). 3,5-dimethylorsellinic acid is then prenylated by the polyprenyl transferase ausN (PubMed:22329759). Further epoxidation by the FAD-dependent monooxygenase ausM and cyclization by the probable terpene cyclase ausL lead to the formation of protoaustinoid A (PubMed:22329759). Protoaustinoid A is then oxidized to spiro-lactone preaustinoid A3 by the combined action of the FAD-binding monooxygenases ausB and ausC, and the dioxygenase ausE (PubMed:22329759, PubMed:23865690). Acid-catalyzed keto-rearrangement and ring contraction of the tetraketide portion of preaustinoid A3 by ausJ lead to the formation of preaustinoid A4 (PubMed:22329759). The aldo-keto reductase ausK, with the help of ausH, is involved in the next step by transforming preaustinoid A4 into isoaustinone which is in turn hydroxylated by the P450 monooxygenase ausI to form austinolide (PubMed:22329759). Finally, the cytochrome P450 monooxygenase ausG modifies austinolide to austinol (PubMed:22329759). Austinol can be further modified to dehydroaustinol which forms a diffusible complex with diorcinol that initiates conidiation (PubMed:22234162, PubMed:22329759). Due to genetic rearrangements of the clusters and the subsequent loss of some enzymes, the end products of the Emericella nidulans austinoid biosynthesis clusters are austinol and dehydroaustinol, even if additional enzymes, such as the O-acetyltransferase ausQ and the cytochrome P450 monooxygenase ausR are still functional (PubMed:29076725).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Secondary metabolite biosynthesis; terpenoid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="5">Impairs the synthesis of austinol and dehydroaustinol (PubMed:22329759).</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="10">In A.calidoustus, the austinoid gene cluster lies on a contiguous DNA region, while clusters from E.nidulans and P.brasilianum are split in their respective genomes. Genetic rearrangements provoked variability among the clusters and E.nidulans produces the least number of austionoid derivatives with the end products austinol and dehydroaustinol, while P.brasilianum can produce until acetoxydehydroaustin, and A.calidoustus produces the highest number of identified derivatives.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="9"/>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF87267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VQ98"/>
    <dbReference type="SMR" id="C8VQ98"/>
    <dbReference type="STRING" id="227321.C8VQ98"/>
    <dbReference type="GlyCosmos" id="C8VQ98">
        <property type="glycosylation" value="1 site, No reported glycans"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CBF87267">
        <property type="protein sequence ID" value="CBF87267"/>
        <property type="gene ID" value="ANIA_11206"/>
    </dbReference>
    <dbReference type="KEGG" id="ani:ANIA_11206"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN11206"/>
    <dbReference type="eggNOG" id="KOG2614">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009665_12_2_1"/>
    <dbReference type="InParanoid" id="C8VQ98"/>
    <dbReference type="OMA" id="SIGLWPN"/>
    <dbReference type="OrthoDB" id="10029326at2759"/>
    <dbReference type="UniPathway" id="UPA00213"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900560">
        <property type="term" value="P:austinol biosynthetic process"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900563">
        <property type="term" value="P:dehydroaustinol biosynthetic process"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000578">
        <property type="entry name" value="FAD-dependent monooxygenase ausM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050562">
        <property type="entry name" value="FAD_mOase_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47356:SF2">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47356">
        <property type="entry name" value="FAD-DEPENDENT MONOOXYGENASE ASQG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0274">FAD</keyword>
    <keyword id="KW-0285">Flavoprotein</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0503">Monooxygenase</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000436494" description="FAD-dependent monooxygenase ausM">
        <location>
            <begin position="1"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="449"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="224"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="316"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="329"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="B8M9J8"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="22234162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="22329759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="6">
        <source>
            <dbReference type="PubMed" id="23865690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="7">
        <source>
            <dbReference type="PubMed" id="29076725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="8">
        <source>
            <dbReference type="PubMed" id="22329759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="9"/>
    <evidence type="ECO:0000305" key="10">
        <source>
            <dbReference type="PubMed" id="29076725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CBF87267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="479" mass="53183" checksum="B7C137DFC609A7B1" modified="2009-11-03" version="1">MSDTPTRKTDLRVIIVGGSVAGLTLAHCLANANIDHIVLEKRAEISPQEGAFLGIWPNGGRIFDQLGVYADLEKCTVPIHKMRVRFPDGVSFSSELPRQVQERFGYPIISLDRQKVLEILYNRYPAKSNIHVNKKVTEIRQTEREAQVLTADGAVYKGDLVVGADGIHSAVRAEMWRQAKDLVGRRDRQDVNHEIAAFTVEYACVFGISSPISGLESGEHVNSYSNGLCVITFHGKDGRVFWFILIKLQKRFIYPFTPRFSASDAAKICAEYANVPVWGDICVRDLWGNKTSVSMTALEEGLLETWRFKRVVLLGDSIHKMTPNIGQGANTAAEDAGVLASLLQRLSTSDSSATSCTIDAVLQEYASLRYERVKSTYQRAYFGARLHTRDDALKAFVGRYIFPRFRQQVLERTSQAIAGAPQVDFLPTPKRTGPGWSDYAGSPEVGAPTLPWLVISLPVLASMLCYLVYSSVFVTPIFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>C8VRM0</accession>
    <name>C8VRM0_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Importin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ANIA_01401</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex. Involved in pre-tRNA splicing, probably by affecting the interaction of pre-tRNA with splicing endonuclease.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the exportin family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF87570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468980.1">
        <property type="nucleotide sequence ID" value="XM_050613142.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VRM0"/>
    <dbReference type="FunCoup" id="C8VRM0">
        <property type="interactions" value="1417"/>
    </dbReference>
    <dbReference type="STRING" id="227321.C8VRM0"/>
    <dbReference type="GeneID" id="2877179"/>
    <dbReference type="KEGG" id="ani:ANIA_01401"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN1401"/>
    <dbReference type="eggNOG" id="KOG2020">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011906_0_0_1"/>
    <dbReference type="InParanoid" id="C8VRM0"/>
    <dbReference type="OMA" id="WAFKHNN"/>
    <dbReference type="OrthoDB" id="27218at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005049">
        <property type="term" value="F:nuclear export signal receptor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061608">
        <property type="term" value="F:nuclear import signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030619">
        <property type="term" value="F:U1 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030620">
        <property type="term" value="F:U2 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030621">
        <property type="term" value="F:U4 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030623">
        <property type="term" value="F:U5 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034501">
        <property type="term" value="P:protein localization to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071528">
        <property type="term" value="P:tRNA re-export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000490">
        <property type="entry name" value="CRM1p Major karyopherin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041123">
        <property type="entry name" value="CRM1_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041235">
        <property type="entry name" value="Exp1_repeat_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013598">
        <property type="entry name" value="Exportin-1/Importin-b-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045065">
        <property type="entry name" value="XPO1/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014877">
        <property type="entry name" value="XPO1_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040485">
        <property type="entry name" value="XPO1_repeat_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11223">
        <property type="entry name" value="EXPORTIN 1/5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11223:SF2">
        <property type="entry name" value="EXPORTIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08767">
        <property type="entry name" value="CRM1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18777">
        <property type="entry name" value="CRM1_repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18784">
        <property type="entry name" value="CRM1_repeat_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18787">
        <property type="entry name" value="CRM1_repeat_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08389">
        <property type="entry name" value="Xpo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01102">
        <property type="entry name" value="CRM1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="8">
        <location>
            <begin position="26"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBF87570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="1072" mass="123353" checksum="49A4FE019E2A18EA" modified="2009-11-03" version="1">MSVSIQELDTTVQAFYEGKGELQKQAQQTLTEFKQNPDAWLIVGNILQESQYPQTKYLALQVLDDVIMTRWKVLPRDQCLGIRNFIVNFIIENSKSEEKLRSERAFLNKLNLVLVSILKQEWPHNWPTFINEIVSSCHTSLSICENNMAILRLLSEEVFDFSQDQMTSVKARNLKTTMTQEFSSIFQLCSEVLTTANQPSLVKATLETLLRFLNWIPLGYIFETPVINTLLTRFLDVPEFRNVTLKCLTEIGGLQIGHPYNYDERLVHMFTETLTTVSKTIPLSMDLKSTYAKSNSRDQEFVLNLALFLCSFFSAHLNLVEKLPNRDYLTHAHFYLIRISQIDDREVFKICLEYWTRLVQELYEEMQQLPITDINPLVSMGVSGLSNGGAPHPNTLAGYPLRKHKYDEVLSSLRTVMIEKMVRPEEVLIVENEEGEIIREFVKESDTIQLYKTIRECLVYLTHLDVIDTENIMIEKLAKQVDGTEWSWANCNTLCWAIGSISGAMNEETEKRFLVTVIKDLLGLTEMKRGKDNKAVVASNIMYIVGQYPRFLKAHWKFLKTVVNKLFEFMHETHEGVQDMACDTFIKIANKCRRHFVALQPGENEPFIEEIVRNMRKITCDLSPQQVHTFYEACGYMISAQGQKGLQDRLIENLMSLPNSAWDTIIAQANQDPSVLQDGETIKIIGNIMKTNVAACSSVGTYFYSQLGRIYHDMLNMFRASSQLINDAVARDGDIATKTPKVRGLRTIKREILKLIDTYVQKADDLEMVNANMVPPLLEAVLVDYNRNVPNAREAEVLSVMTTVIQKLHNLMDDKVPLIMESVFECTLEMINKDFHEFPDHRIQFFKLLQAINLYCFPALLKLDATQFKFVIDSCMWASKHDNREVENTGLTMCLELMNNMAEVDVQTSNIFFRQFYIPILQDVFFVLTDSDHKAGFKSQAMLLSRMFYFIESGKIQDPIYSPEQAPIGTSNKDFLQKYVADLLQTAFKNLQEIQIKQFVVGLFAFNDDFNKFKTHLRDFLISLKEFAGDNAELYAEEREQALKDAKAAERDRAMRVGGLLKPSEMDHDDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C8VTW7</accession>
    <name>C8VTW7_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Beta-xylosidase C-terminal Concanavalin A-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ANIA_01043</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF88272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_658647.2">
        <property type="nucleotide sequence ID" value="XM_653555.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VTW7"/>
    <dbReference type="STRING" id="227321.C8VTW7"/>
    <dbReference type="GeneID" id="2876818"/>
    <dbReference type="KEGG" id="ani:ANIA_01043"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN1043"/>
    <dbReference type="eggNOG" id="ENOG502SIVT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_808993_0_0_1"/>
    <dbReference type="InParanoid" id="C8VTW7"/>
    <dbReference type="OrthoDB" id="408373at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051795">
        <property type="entry name" value="Glycosyl_Hydrlase_43"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42812">
        <property type="entry name" value="BETA-XYLOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42812:SF17">
        <property type="entry name" value="BETA-XYLOSIDASE C-TERMINAL CONCANAVALIN A-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBF88272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="343" mass="39217" checksum="5926C6E928115097" modified="2009-11-03" version="1">METCQSCRYPSFPSTGDCEQYLTDATRWSMGFNIRYRKGKFYLLTSYVSMYPDFGFKGLLFSTEEIYSDEAIRNRTGVGLPEGPHIYKKDNWYYLRIGEGGTELGHRQVIARSHSVTGPNEGYAGNPILTNFNTTEYFQTVGHADLFQDGNGNWWGVVLATRSGPAWRVYPMGRETVLFPATWKRDSFAVSPPERPYSLRLLPSSLNITGLSAAGERIEKTPITLIMRRQSHTYFTYSVEVSFVLAEEGEGGRRGSSNTECQSPELPSRPYHFQRIFESGCRFRLRMTPTIICLLRCQDAKILTLFTLWRLFLLAEELEDLPAFFWESMPQVVGDQAHAIVYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>C8VU83</accession>
    <name>C8VU83_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF2293 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_00985</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF88393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="C8VU83"/>
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    <dbReference type="KEGG" id="ani:ANIA_00985"/>
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    <dbReference type="HOGENOM" id="CLU_792337_0_0_1"/>
    <dbReference type="InParanoid" id="C8VU83"/>
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        <property type="component" value="Chromosome VIII"/>
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    <dbReference type="PANTHER" id="PTHR38113">
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    <dbReference type="PANTHER" id="PTHR38113:SF2">
        <property type="entry name" value="DUF2293 DOMAIN-CONTAINING PROTEIN"/>
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    <dbReference type="Pfam" id="PF10056">
        <property type="entry name" value="DUF2293"/>
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    <proteinExistence type="predicted"/>
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            <begin position="237"/>
            <end position="310"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="41"/>
            <end position="65"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF10056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF88393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="350" mass="39869" checksum="ABBD0B0F7D3FE911" modified="2009-11-03" version="1">MAPIRPKASTKGRKRWGRGKSNHFESRTKRNRKIPRLGINRIERNRTERSSAERQRAERNKVEKSHAVNSIAEKYRAEKQLPWRPPRPLAILAQKHELALSRKALFPQSGPSAASKKPKPVITKSRHGLAKYKPVAQWPSPEPLEMNCLERAPLPPNYVFVPRGDVYVTRHCRSKTKEDHRLVYKVYDNTGKKALGIRVPADVHAAVLRSAEETAESRANAVRARDERELAHNRELLRKQFPLMPAQSLNTILQHAFLKGSGRVGRTTTTPEKEKVILAVEAHIRHVHTPYEELLRSGMPRLEARNKLSRKPCHTTLTIDLTECIRRTRASIATAHAFLSRVFSGSGQRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C8VUW2</accession>
    <name>C8VUW2_EMENI</name>
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        <submittedName>
            <fullName evidence="4">DUF775 domain protein (AFU_orthologue AFUA_5G11100)</fullName>
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        <name evidence="4" type="ORF">ANIA_10034</name>
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        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
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        <lineage>
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            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
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            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the OPI10 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF89989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050469299.1">
        <property type="nucleotide sequence ID" value="XM_050611027.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VUW2"/>
    <dbReference type="FunCoup" id="C8VUW2">
        <property type="interactions" value="341"/>
    </dbReference>
    <dbReference type="STRING" id="227321.C8VUW2"/>
    <dbReference type="GeneID" id="74896161"/>
    <dbReference type="KEGG" id="ani:ANIA_10034"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN10034"/>
    <dbReference type="eggNOG" id="KOG4067">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084839_1_1_1"/>
    <dbReference type="InParanoid" id="C8VUW2"/>
    <dbReference type="OMA" id="WWAKFER"/>
    <dbReference type="OrthoDB" id="10248398at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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        <property type="evidence" value="ECO:0000318"/>
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        <property type="term" value="F:nuclear import signal receptor activity"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="entry name" value="Hikeshi-like_C"/>
    </dbReference>
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        <property type="entry name" value="Hikeshi-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031318">
        <property type="entry name" value="OPI10"/>
    </dbReference>
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        <property type="entry name" value="HIKESHI FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PROTEIN HIKESHI"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Hikeshi-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hikeshi-like N-terminal" evidence="2">
        <location>
            <begin position="5"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Hikeshi-like C-terminal" evidence="3">
        <location>
            <begin position="154"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBF89989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="217" mass="23095" checksum="0AC2B5810E9A8F7B" modified="2009-11-03" version="1">MFSVIIPGRPCLTDIVAVDPQPNGQATKFAFNFPLSPSFSELVVFFLPGTVLPQDTAAAIYIQYPGSEFRFIGALANEKPSSVIKVSPSVRTGAQGGDQMVDAGNGGMVTLGISIEPVQVVAPQLAQLEAANGGNGGASTDLIKQTPQQKGITTKVLAQRIVGNAFNFLASFASSDPSNRGQEVVPLKAFHDWWTKFERRINVDPTFLEREDPSASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-12-14" modified="2025-10-08" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>G5EB69</accession>
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    <name>G5EB69_EMENI</name>
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        <recommendedName>
            <fullName evidence="20">DNA polymerase</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="27" type="ORF">ANIA_04789</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
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    <reference evidence="28" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="28">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="28" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="28">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 20">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="19">Forms DNA polymerase zeta with REV7.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 20">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 20">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="20"/>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF76778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_662393.1">
        <property type="nucleotide sequence ID" value="XM_657301.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="G5EB69">
        <property type="interactions" value="664"/>
    </dbReference>
    <dbReference type="STRING" id="227321.G5EB69"/>
    <dbReference type="GeneID" id="2872590"/>
    <dbReference type="KEGG" id="ani:ANIA_04789"/>
    <dbReference type="eggNOG" id="KOG0968">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000203_3_1_1"/>
    <dbReference type="InParanoid" id="G5EB69"/>
    <dbReference type="OMA" id="GRNKMGF"/>
    <dbReference type="OrthoDB" id="2414538at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016035">
        <property type="term" value="C:zeta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd05778">
        <property type="entry name" value="DNA_polB_zeta_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05534">
        <property type="entry name" value="POLBc_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.60:FF:000007">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.342.10:FF:000018">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.690:FF:000002">
        <property type="entry name" value="DNA polymerase zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000024">
        <property type="entry name" value="DNA polymerase zeta catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.60">
        <property type="entry name" value="DNA polymerase family B, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.342.10">
        <property type="entry name" value="DNA Polymerase, chain B, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.690">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006172">
        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017964">
        <property type="entry name" value="DNA-dir_DNA_pol_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006133">
        <property type="entry name" value="DNA-dir_DNA_pol_B_exonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006134">
        <property type="entry name" value="DNA-dir_DNA_pol_B_multi_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042087">
        <property type="entry name" value="DNA_pol_B_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056435">
        <property type="entry name" value="DPOD/Z_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030559">
        <property type="entry name" value="PolZ_Rev3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056447">
        <property type="entry name" value="REV3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025687">
        <property type="entry name" value="Znf-C4pol"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45812">
        <property type="entry name" value="DNA POLYMERASE ZETA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45812:SF1">
        <property type="entry name" value="DNA POLYMERASE ZETA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00136">
        <property type="entry name" value="DNA_pol_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03104">
        <property type="entry name" value="DNA_pol_B_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24055">
        <property type="entry name" value="POL3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24065">
        <property type="entry name" value="REV3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14260">
        <property type="entry name" value="zf-C4pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00106">
        <property type="entry name" value="DNAPOLB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00486">
        <property type="entry name" value="POLBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00116">
        <property type="entry name" value="DNA_POLYMERASE_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 20" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="16" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7 20" id="KW-0235">DNA replication</keyword>
    <keyword evidence="15 20" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="12 20" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="13 20" id="KW-0408">Iron</keyword>
    <keyword evidence="14 20" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 20" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 20" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="17 20" id="KW-0539">Nucleus</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 20" id="KW-0808">Transferase</keyword>
    <keyword evidence="11 20" id="KW-0862">Zinc</keyword>
    <keyword evidence="10 20" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DNA polymerase zeta catalytic subunit N-terminal" evidence="26">
        <location>
            <begin position="4"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="DNA polymerase delta/zeta catalytic subunit N-terminal" evidence="25">
        <location>
            <begin position="61"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B exonuclease" evidence="23">
        <location>
            <begin position="832"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B multifunctional" evidence="22">
        <location>
            <begin position="1084"/>
            <end position="1531"/>
        </location>
    </feature>
    <feature type="domain" description="C4-type zinc-finger of DNA polymerase delta" evidence="24">
        <location>
            <begin position="1578"/>
            <end position="1650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="287"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="407"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="455"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="495"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="608"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="21">
        <location>
            <begin position="415"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="495"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="529"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="554"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
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    </evidence>
    <evidence type="ECO:0000256" key="7">
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
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    </evidence>
    <evidence type="ECO:0000256" key="11">
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
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    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00066055"/>
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    </evidence>
    <evidence type="ECO:0000256" key="20">
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    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF00136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF03104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF14260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF24055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="Pfam" id="PF24065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="CBF76778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="1681" mass="191414" checksum="D79695A77934F5EE" modified="2011-12-14" version="1">MEPFQVRLNCVDHYQANPSEFDPPLPYRDGNNEKGYMPKVPVIRIFGTTETGQKICVHVHGAFPYLYVQYDGDLSPDSVRSAARSLHLSIDHALAVSYRRNAHDKKTVFVAHITLVKGVPFYGYHVGYRFFFKIYLLNPIYITRLADLLLQGAVMKRPIQPYESHLQYVPQWMCDYNLFGCAFMKCGKAKFRSPIPEYLDLPDLSHRWHDRSIPPGWILDESVLPKQSHCPLEADVCVQDILNRLEISERSIHHDFREFLNPLTSNEKLVPSMAGLWEDEKRRRKKKLGLDDPDSSPFSTEDLVSFSSDPRKASQGDWIHKDELQLLVRQITAEERERDNNRDMTLDAHLQENPYAKDVKTALQSIEDFFTDADGLTNLQLPYNSGIDYSEEQAVDYVDEDAVRATESNSGLYSSDEDGMIDIFSDDDYDNSENEMAQVDLENDLQQDERSNAISKTHGPRVSAPSVDGLAGNSSGLEGPRSDALEARNAISFKAPTQQNVQSGRSSVTRSKYEENLDKSSQSQESSSLVQFWTANADSSNKKIRMPSRATEPSSSDGQSISSQKTIRLKALSQYGTLNFPVVKDPNDPMTILRFSQEASGSKELMDVVAKEASSSGKSSSTLQPRSSDEKELSSSSDNIATDFAGLISDAFNIPPSTRLCCFRRACPSPKEVSSTINAYGLSDIIYQNAHYSIDADVPDRPRDYAGKEFQLGGIGIRYLPDFDPSGRLPAMLAEENIGQKEKRDWQELDHQLRVGSTARFWEFTPVPPSRSEVITWYNGEQQKSLAATTKTEEQYEEKEYRGKVLSQIEGPTQKNEHGFKYSQHKKSTSVEHQTQYMSTMSLEVHVNTRGVLLPNPEEDEIAAFFWCVNSEDEPQEEDDSLSVVNMGVVFQGEEEYPESKISKALRFECEHESTELDLINRLVDIVRLHDPDIITGYEVHNSSWGFIIERARKKYDFDLCDELSRVKSHAHGRFGKEADKWGFDHTSSIRITGRHIINIWRAMRSEMNLLQYTMENVVFHLLHRRIPHYSFRDLTAWYQSDKPRDFMKVINYYTSRVQMNIEILNANELIPRTSEQARLLGIDFYSVFSRGSQFKVESLMFRIAKPENFILVSPSRKQVGQQNALECLPLVMEPQSDFYTSPLIVLDFQSLYPSIMIAYNYCYSTFLGRVQSWRGRNKMGFLDYNRPPRLLELLKDHINIAPNGMIYARSEVRKSLLAKMLTEILETRVMVKTGMKVDKDDRALQRLLNNRQLALKLIANVTYGYTSASFSGRMPCSEIADSIVQSGRETLEKAIAFIHSVERWGAEVVYGDTDSLFVYLKGRTRDQAFDIGEEIAQAVTNMNPHPVKLKFEKVYHPCVLLAKKRYVGFKYEHRNQKEPEFDAKGIETVRRDGTPAEQKIEEKALKLLFRTADLSQVKSYFQSQCTKIMQGRVSVQDFCFARAVKLGTYSENGTLPAGALISTKKMLEDPRAEPQYGERVPYVVVTGAPGSRLIDRCVPPETLLQDAQLDLDAEYYITKNIIPPLERIFNLVGANVRQWYDEMPKVHRIRRVEGTSSLAGGKSSIRTLESYMKASSCVVCKAKLYDAEIPVCSDCVRQPHVSLLELVSRQRHAEQRVATLERICRSCMDVPFGDEVKCDSLDCPVFYARTRGLAHWRHTNSVLGPVIKLLQDNCSDSLEW</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1994-10-01" modified="2025-06-18" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>P38096</accession>
    <accession>C8VPY3</accession>
    <accession>Q5BEZ4</accession>
    <name>LAMB_EMENI</name>
    <protein>
        <recommendedName>
            <fullName>Lactam utilization protein lamB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">lamB</name>
        <name type="ORF">AN0886</name>
    </gene>
    <organism>
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1992" name="Mol. Cell. Biol." volume="12" first="337" last="346">
            <title>Molecular characterization of the lam locus and sequences involved in regulation by the AmdR protein of Aspergillus nidulans.</title>
            <authorList>
                <person name="Richardson I.B."/>
                <person name="Katz M.E."/>
                <person name="Hynes M.J."/>
            </authorList>
            <dbReference type="PubMed" id="1729609"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>biA1 niiA4</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="1978" name="Mol. Gen. Genet." volume="166" first="321" last="327">
            <title>Lactam utilisation in Aspergillus nidulans: evidence for a fourth gene under the control of the integrator gene intA.</title>
            <authorList>
                <person name="Arst H.N. Jr."/>
                <person name="Penfold H.A."/>
                <person name="Bailey C.R."/>
            </authorList>
            <dbReference type="PubMed" id="368580"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="1989" name="Gene" volume="78" first="167" last="171">
            <title>Gene function identified by interspecific transformation.</title>
            <authorList>
                <person name="Katz M.E."/>
                <person name="Hynes M.J."/>
            </authorList>
            <dbReference type="PubMed" id="2670678"/>
            <dbReference type="DOI" id="10.1016/0378-1119(89)90324-7"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="1989" name="Genetics" volume="122" first="331" last="339">
            <title>Characterization of the amdR-controlled lamA and lamB genes of Aspergillus nidulans.</title>
            <authorList>
                <person name="Katz M.E."/>
                <person name="Hynes M.J."/>
            </authorList>
            <dbReference type="PubMed" id="2670667"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INDUCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="1 2 3">Involved in the utilization of lactams. Required for the conversion of exogenous 2-pyrrolidinone (gamma-butyrolactam) to endogenous gamma-amino-n-butyrate (GABA).</text>
    </comment>
    <comment type="induction">
        <text evidence="1">By beta-alanine.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the LamB/PxpA family.</text>
    </comment>
    <comment type="sequence caution" evidence="4">
        <conflict type="frameshift">
            <sequence resource="EMBL-CDS" id="AAA33313" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EMBL" id="M77283">
        <property type="protein sequence ID" value="AAA33313.1"/>
        <property type="status" value="ALT_FRAME"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AACD01000014">
        <property type="protein sequence ID" value="EAA65915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF88590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="B42064">
        <property type="entry name" value="B42064"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_658490.1">
        <property type="nucleotide sequence ID" value="XM_653398.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P38096"/>
    <dbReference type="SMR" id="P38096"/>
    <dbReference type="STRING" id="227321.P38096"/>
    <dbReference type="EnsemblFungi" id="CBF88590">
        <property type="protein sequence ID" value="CBF88590"/>
        <property type="gene ID" value="ANIA_00886"/>
    </dbReference>
    <dbReference type="KEGG" id="ani:ANIA_00886"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN0886"/>
    <dbReference type="eggNOG" id="ENOG502S0UZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069535_1_0_1"/>
    <dbReference type="InParanoid" id="P38096"/>
    <dbReference type="OMA" id="PHGRLGN"/>
    <dbReference type="OrthoDB" id="5295431at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009448">
        <property type="term" value="P:gamma-aminobutyric acid metabolic process"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="CDD" id="cd11665">
        <property type="entry name" value="LamB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.370:FF:000017">
        <property type="entry name" value="Lactam utilization protein lamB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005501">
        <property type="entry name" value="LamB/YcsF/PxpA-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003814">
        <property type="entry name" value="PRK05406.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30292:SF0">
        <property type="entry name" value="5-OXOPROLINASE SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30292">
        <property type="entry name" value="UNCHARACTERIZED PROTEIN YBGL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03746">
        <property type="entry name" value="LamB_YcsF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000185068" description="Lactam utilization protein lamB">
        <location>
            <begin position="1"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000269" key="1">
        <source>
            <dbReference type="PubMed" id="2670667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="2670678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="368580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="253" mass="27946" checksum="E858F5F940CB9001" modified="2009-05-26" version="2">MAPIKKKALINCDMGEAYGNWTCGPDLELLPLIDIANIACGFHAGDPLIMMETVRNCKAHNILVGAHPGLPDIQGFGRREMKLSPEELTAITIYQVGALQGFLDREGVRLNHVKPHGVLYGMMCRDYEVAKAVMLGIPKGIPVFGLPGTNMEKAANDLGIEFRAEFYGDVKYDSNGMLVIDRKKKPWDPADVEKHVRQQLEDQSVTSVDGVVVPLPIKDYDVSICCHSDSPGCLEIIKTTKKVVDEFNKKYGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AQC0</accession>
    <accession>C8VNY8</accession>
    <name>Q5AQC0_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_09510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF86824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_868892.1">
        <property type="nucleotide sequence ID" value="XM_863799.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AQC0"/>
    <dbReference type="STRING" id="227321.Q5AQC0"/>
    <dbReference type="GeneID" id="3684109"/>
    <dbReference type="KEGG" id="ani:ANIA_09510"/>
    <dbReference type="HOGENOM" id="CLU_1012038_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AQC0"/>
    <dbReference type="OMA" id="TASDRHQ"/>
    <dbReference type="OrthoDB" id="5382952at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="33"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF86824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="275" mass="30143" checksum="CB1CABFACE4F66DD" modified="2005-04-26" version="1">MSYKSDGGRIPRLRELGHRSRNASTPTIATLPSGYGSANSSYSGPQIPRLAMRPTKSRRAASMSEAEENRPIVAQSNFVLSSDPRPYMPPRAPTHPPESYSTLNQHVHRTLHTPVVPQTPIDNRPPVQTRPRNVLRRKAPTIGQQNANSKLQADSMRPSGLNVIIPSITASDRHQYSSSQSSSRTELARESRSPMLSPDKVTTVSAEQKVHNGPKELASLRTTINTRDLAPSTPIFPSASTPSTRYSGSPGVWTQSLTYQITDIFTPDAEARTPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="104" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AQN6</accession>
    <accession>C8VRJ7</accession>
    <name>Q5AQN6_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Succinyl-CoA:3-ketoacid-coenzyme A transferase</fullName>
            <ecNumber evidence="3">2.8.3.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ANIA_09394</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a 3-oxo acid + succinyl-CoA = a 3-oxoacyl-CoA + succinate</text>
            <dbReference type="Rhea" id="RHEA:24564"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:35973"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="2.8.3.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Ketone metabolism; succinyl-CoA degradation; acetoacetyl-CoA from succinyl-CoA: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the 3-oxoacid CoA-transferase family.</text>
    </comment>
    <dbReference type="EC" id="2.8.3.5" evidence="3"/>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF87529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_682663.1">
        <property type="nucleotide sequence ID" value="XM_677571.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AQN6"/>
    <dbReference type="STRING" id="227321.Q5AQN6"/>
    <dbReference type="GeneID" id="2867932"/>
    <dbReference type="KEGG" id="ani:ANIA_09394"/>
    <dbReference type="eggNOG" id="KOG3822">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019942_1_1_1"/>
    <dbReference type="InParanoid" id="Q5AQN6"/>
    <dbReference type="OMA" id="GMGPHPT"/>
    <dbReference type="OrthoDB" id="1933379at2759"/>
    <dbReference type="UniPathway" id="UPA00929">
        <property type="reaction ID" value="UER00894"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008410">
        <property type="term" value="F:CoA-transferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008260">
        <property type="term" value="F:succinyl-CoA:3-oxo-acid CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046952">
        <property type="term" value="P:ketone body catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1080.10">
        <property type="entry name" value="Glutaconate Coenzyme A-transferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014388">
        <property type="entry name" value="3-oxoacid_CoA-transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004165">
        <property type="entry name" value="CoA_trans_fam_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13707:SF60">
        <property type="entry name" value="ACETATE COA-TRANSFERASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13707">
        <property type="entry name" value="KETOACID-COENZYME A TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01144">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000858">
        <property type="entry name" value="SCOT-t"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00882">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 5" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="5-glutamyl coenzyme A thioester intermediate" evidence="4">
        <location>
            <position position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000858-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBF87529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="439" mass="46797" checksum="343C4FF70C8A7DCD" modified="2005-04-26" version="1">MADTLITAIARRGAENIHSLTAVSNNAGAPGKGGLSTLTQSGQVDRLIISYLGNNKALEKKYLTGNIAIELCPQGTLAERLRAGGAGIPAFYTATGAHTFLQDGRIPVRVDASGNVLEHGKPRETRVFNNKTYLMETALTGDVAILRAWKVDEAGNCVFRYTTKAFGPIMAKAATLTIVEAENIVPVGSIDPNDVDLPGIFVDRIVPSTAEKQIEIRKLRQSQEDGSTAAGVSPAIIQRNRIAKRAAKELKQGYYVNLGVGIPTLAPSMLPEGVKVWIQSENGILGMVRQERRGNRTDIINAGKETVTLLPGAATFDSTESFGMIRGGHVDVSILGALQVFKGMGGAMDLISNPDQTKIVVATSHTAKDGLPKIVTECSLPLTGANCVSTIVTELCVFQVDRQKGELTLTELAPGVDVNEVREKTGAPFHVADKLEVME</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2021-02-10" modified="2025-06-18" version="124" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AQQ0</accession>
    <accession>A0A1U8QU02</accession>
    <accession>B3VD86</accession>
    <accession>C8VR85</accession>
    <name>CDA_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Chitin deacetylase</fullName>
            <ecNumber evidence="5 6">3.5.1.41</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">AnCDA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">cda</name>
        <name evidence="10" type="ORF">ANIA_09380</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2010" name="Appl. Biochem. Biotechnol." volume="162" first="843" last="854">
            <title>Cloning of a heat-stable chitin deacetylase gene from Aspergillus nidulans and its functional expression in Escherichia coli.</title>
            <authorList>
                <person name="Wang Y."/>
                <person name="Song J.Z."/>
                <person name="Yang Q."/>
                <person name="Liu Z.H."/>
                <person name="Huang X.M."/>
                <person name="Chen Y."/>
            </authorList>
            <dbReference type="PubMed" id="19760058"/>
            <dbReference type="DOI" id="10.1007/s12010-009-8772-z"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA]</scope>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>COFACTOR</scope>
        <scope>ACTIVITY REGULATION</scope>
        <scope>BIOPHYSICOCHEMICAL PROPERTIES</scope>
        <source>
            <strain evidence="9">AF93062</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="journal article" date="2017" name="Sci. Rep." volume="7" first="1746" last="1746">
            <title>Structure and function of a broad-specificity chitin deacetylase from Aspergillus nidulans FGSC A4.</title>
            <authorList>
                <person name="Liu Z."/>
                <person name="Gay L.M."/>
                <person name="Tuveng T.R."/>
                <person name="Agger J.W."/>
                <person name="Westereng B."/>
                <person name="Mathiesen G."/>
                <person name="Horn S.J."/>
                <person name="Vaaje-Kolstad G."/>
                <person name="van Aalten D.M.F."/>
                <person name="Eijsink V.G.H."/>
            </authorList>
            <dbReference type="PubMed" id="28496100"/>
            <dbReference type="DOI" id="10.1038/s41598-017-02043-1"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.99 ANGSTROMS) OF 19-237 IN COMPLEX WITH COBALT</scope>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>COFACTOR</scope>
        <scope>BIOPHYSICOCHEMICAL PROPERTIES</scope>
    </reference>
    <comment type="function">
        <text evidence="5 6">Hydrolyzes the N-acetamido groups of N-acetyl-D-glucosamine polymers in chitin to form chitosan and acetate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + n H2O = chitosan + n acetate</text>
            <dbReference type="Rhea" id="RHEA:10464"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9597"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:57704"/>
            <dbReference type="EC" id="3.5.1.41"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5 6">
            <dbReference type="Rhea" id="RHEA:10465"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <text evidence="5 6">Evidence supports a metal cofactor but evidence for cobalt is inconsistent.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="5">Inhibited by metal chelator ethylenediaminetetraacetic acid (EDTA).</text>
    </comment>
    <comment type="biophysicochemical properties">
        <kinetics>
            <KM evidence="6">0.072 mM for GlcNAc(5) (at 37 degrees Celsius, pH 8 and in presence of Co(2+))</KM>
            <text evidence="6">kcat is 7 sec(-1) with GlcNAc(5) as substrate.</text>
        </kinetics>
        <phDependence>
            <text evidence="5">Optimum pH is 8.</text>
        </phDependence>
        <temperatureDependence>
            <text evidence="5">Optimum temperature is 50 degrees Celsius.</text>
        </temperatureDependence>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the polysaccharide deacetylase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.41" evidence="5 6"/>
    <dbReference type="EMBL" id="EU734183">
        <property type="protein sequence ID" value="ACE79177.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF87506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AACD01000172">
        <property type="protein sequence ID" value="EAA66447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_682649.1">
        <property type="nucleotide sequence ID" value="XM_677557.1"/>
    </dbReference>
    <dbReference type="PDB" id="2Y8U">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.99 A"/>
        <property type="chains" value="A/B=19-237"/>
    </dbReference>
    <dbReference type="PDBsum" id="2Y8U"/>
    <dbReference type="AlphaFoldDB" id="Q5AQQ0"/>
    <dbReference type="SMR" id="Q5AQQ0"/>
    <dbReference type="FunCoup" id="Q5AQQ0">
        <property type="interactions" value="33"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5AQQ0"/>
    <dbReference type="GlyCosmos" id="Q5AQQ0">
        <property type="glycosylation" value="1 site, No reported glycans"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CBF87506">
        <property type="protein sequence ID" value="CBF87506"/>
        <property type="gene ID" value="ANIA_09380"/>
    </dbReference>
    <dbReference type="GeneID" id="2867795"/>
    <dbReference type="KEGG" id="ani:ANIA_09380"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN9380"/>
    <dbReference type="eggNOG" id="ENOG502QRIP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021264_11_1_1"/>
    <dbReference type="InParanoid" id="Q5AQQ0"/>
    <dbReference type="OMA" id="DLWASDW"/>
    <dbReference type="OrthoDB" id="2125469at2759"/>
    <dbReference type="BRENDA" id="3.5.1.41">
        <property type="organism ID" value="517"/>
    </dbReference>
    <dbReference type="SABIO-RK" id="Q5AQQ0"/>
    <dbReference type="EvolutionaryTrace" id="Q5AQQ0"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004099">
        <property type="term" value="F:chitin deacetylase activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10951">
        <property type="entry name" value="CE4_ClCDA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46471">
        <property type="entry name" value="CHITIN DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46471:SF2">
        <property type="entry name" value="CHITIN DEACETYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0002">3D-structure</keyword>
    <keyword id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword id="KW-0146">Chitin degradation</keyword>
    <keyword id="KW-0147">Chitin-binding</keyword>
    <keyword id="KW-0170">Cobalt</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0624">Polysaccharide degradation</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010241342" description="Chitin deacetylase" evidence="2">
        <location>
            <begin position="19"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="4">
        <location>
            <begin position="40"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="47"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>acetate</name>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>acetate</name>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
        </ligand>
    </feature>
    <feature type="site" description="May prevent de-N-acetylated sugar residues from interacting with the active site" evidence="7">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <feature type="strand" evidence="15">
        <location>
            <begin position="29"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="strand" evidence="15">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="helix" evidence="15">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="strand" evidence="15">
        <location>
            <begin position="69"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="helix" evidence="15">
        <location>
            <begin position="74"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="helix" evidence="15">
        <location>
            <begin position="81"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="strand" evidence="15">
        <location>
            <begin position="93"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="helix" evidence="15">
        <location>
            <begin position="104"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="helix" evidence="15">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="strand" evidence="15">
        <location>
            <begin position="128"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="helix" evidence="15">
        <location>
            <begin position="137"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="helix" evidence="15">
        <location>
            <begin position="143"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="strand" evidence="15">
        <location>
            <begin position="155"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="strand" evidence="15">
        <location>
            <begin position="160"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="helix" evidence="15">
        <location>
            <begin position="165"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="helix" evidence="15">
        <location>
            <begin position="173"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="helix" evidence="15">
        <location>
            <begin position="178"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="strand" evidence="15">
        <location>
            <begin position="192"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="helix" evidence="15">
        <location>
            <begin position="200"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="helix" evidence="15">
        <location>
            <begin position="206"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="strand" evidence="15">
        <location>
            <begin position="220"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="helix" evidence="15">
        <location>
            <begin position="224"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="helix" evidence="15">
        <location>
            <begin position="232"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="Q6DWK3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="19760058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="6">
        <source>
            <dbReference type="PubMed" id="28496100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="7">
        <source>
            <dbReference type="PubMed" id="28496100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="8"/>
    <evidence type="ECO:0000312" key="9">
        <source>
            <dbReference type="EMBL" id="ACE79177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="10">
        <source>
            <dbReference type="EMBL" id="CBF87506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CBF87506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0007744" key="14">
        <source>
            <dbReference type="PDB" id="2Y8U"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="15">
        <source>
            <dbReference type="PDB" id="2Y8U"/>
        </source>
    </evidence>
    <sequence length="237" mass="26014" checksum="16DF188E3D652A3E" modified="2005-04-26" version="1" precursor="true">MFATLALVFTALASNALTTPLPLVRRVPTGQVITQCTTPNTIALTFDDGPSEYTPQLLDLLSRYSARATFFVLGDAAAQNPGLLQRMRDEGHQVGAHTYDHVSLPSLGYDGIASQMTRLEEVIRPALGVAPAYMRPPYLETNELVLQVMRDLDYRVISASVDTKDYENQDADAIINTSFQLFLDQLDAGGNIVLAHDIHYWTVASLAERMLQEVNARGLIATTVGDCLGDGEIAWYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="136" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ARA7</accession>
    <accession>C8VK17</accession>
    <name>Q5ARA7_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">MFS glucose transporter, putative (AFU_orthologue AFUA_8G00890)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ANIA_09173</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF82391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_682442.1">
        <property type="nucleotide sequence ID" value="XM_677350.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ARA7"/>
    <dbReference type="GeneID" id="2868085"/>
    <dbReference type="KEGG" id="ani:ANIA_09173"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_12_1"/>
    <dbReference type="InParanoid" id="Q5ARA7"/>
    <dbReference type="OMA" id="VFFMYPE"/>
    <dbReference type="OrthoDB" id="4142200at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000026">
        <property type="entry name" value="MFS quinate transporter QutD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF54">
        <property type="entry name" value="GLUCOSE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G00890)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="7"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="276"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="311"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="358"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="394"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="425"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="10"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="481"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="490"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CBF82391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="500" mass="55032" checksum="37F0720BE3EEFBA4" modified="2005-04-26" version="1">MYRINNIYVLAAFGTIGGALFGFDVSSMSAFLATDQYLEFFNHPNSDLQGGITASMSAGSFAGAIAAGFIADHVGRRKSLMVASLVWIIGAVIQCSAQNVAHLVAGRVISGLSVGVTSSQVCVYLAELAPARIRGRIVGIQQWAIEWGILIMYLISWGCGKGIAGPSAFRVAWGVQAVPGLVLFLALFFFPESPRWLASRERWEEALDVLAALHGKGNRNDPVVQVEFEEVKEAARLAAEAKDVSFFALFGPRIWKRTLCGVSCQVWQQLLGGNVAMYYVVWIFQMAGMYVIFVATTGVILPYIDRIGRRLLLVSGAIICMIIHYAIAAVMATRGNPVDEINGNASLKWEITGASGKAVIAMSYIFVGVYGLTWAPAAWIYASEVFPLKYRAKGVGLSAAGNWIFNFALAYFVAPAFTNIQWKTYIIFGVFCTVMTFHVFFMYPETAQRSLEEIDLMFDTHVKPWQTAKLQDRFEEEVERQRKQSVAEAHVGDASHKEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ARU7</accession>
    <accession>C8VL19</accession>
    <name>Q5ARU7_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter, putative (AFU_orthologue AFUA_2G02040)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ANIA_08983</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF84519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_682252.1">
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        <property type="entry name" value="MFS_trans_sf"/>
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        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
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        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G02040)-RELATED"/>
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        <property type="entry name" value="MFS_1"/>
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        <property type="entry name" value="MFS general substrate transporter"/>
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    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="72"/>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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    <feature type="transmembrane region" description="Helical" evidence="6">
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    <feature type="transmembrane region" description="Helical" evidence="6">
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    <feature type="transmembrane region" description="Helical" evidence="6">
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="274"/>
            <end position="286"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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        <source>
            <dbReference type="EMBL" id="CBF84519.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="561" mass="61763" checksum="E3B65B04964A24C8" modified="2005-04-26" version="1">MDDISQSEVPGTIFIVGTDATKLGEADVTTSNDIVLVPRPLETPRDPLNWPKSKKLWTLFLATLFATVVAYGENNLGAPWTEVAEDIDVTMKDMNGGSALNYLLLGFVNVLWIPTAMKLGRKVVYIFSMTIIMVSSVWNAYIYGVAQWYLNCLVGGIGQSAYQALIQLTVFDIFFAHQRGTMLAVYVWGQQLGSILALILGGYIAEGPGWRWSCKIVAILSVRLISVILRAAVADALQGSVVLLFIFTMDDSLFPRHALAIHQTTTVPQTQDSHQPEAENDTKKEQSVNLNRQPTISQGRADLLPRNYLHVLAPIHRWKEDKTTWWQYFRRPFHLFAFPNIIMAGLIYAFANTAGIVSFNTISEIMTGAPYNWSTGPTGLMFLAALVGSFIGMATGALGDILTLRLARANGGYKEPEMRLWTLSLSFVYGAVGYFMYGWSASDGKSWVLIAVGLGGMIAQQVSAASVATAYAMECFEGISSELVVVLAICSSCVNFAISYSVQPFIEATDYGRTFTCFGALVLCSLAMAGAGVKWGKSWRRRCASRYWKFLDHLDYALNTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="123" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AS28</accession>
    <accession>C8VLL5</accession>
    <name>Q5AS28_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Zn(II)2Cys6 transcription factor (Eurofung)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ANIA_08902</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF84699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_677079.2"/>
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    <dbReference type="STRING" id="227321.Q5AS28"/>
    <dbReference type="GeneID" id="2868295"/>
    <dbReference type="KEGG" id="ani:ANIA_08902"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN8902"/>
    <dbReference type="eggNOG" id="ENOG502QW96">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009827_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AS28"/>
    <dbReference type="OMA" id="HIHRSQW"/>
    <dbReference type="OrthoDB" id="3034343at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668:SF10">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="30"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="78"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
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            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="117"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBF84699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="723" mass="80594" checksum="D1FF95D44F55B597" modified="2005-04-26" version="1">MPNNAEGTTDPTTPISPSFARPYRSHKVPACDFCRKRRSRCTQEVADQPCLLCRMHGATCTRASSRPGPAKRRRLAVDNAPQDPQEPQQRPSPPPTTESASYAESTHQHPSARDRSTATPVFSQNDASNQSGHIVGPVMARDAQVLERCMSSIPNSAVSYARPNPYSVYSDDTRNPVIYMKVPRQRNIAPSGNGTAGFRQFEAMEKVVEPLGPELCSVYFNNIHPPFPILDEQTVLKAYQQDGLPYALACEIYACSLLLWKSSPKIAASNRPVPDIRYMWNLTVSAMNDDFLSPNFSTILACILDLLGRPITSITYNAVNVGRVVALSQSLGLNRNPSTWGVDSRQKSLRIRTWWGILIHDQWASLSHGTPPHIHKSVWDVPLPDSDSLMVSITPGEVFPPDARVQGAHSFIALCSLTTLLGQILPLIYVLEVQPLEASFRALRRHETALNEWEEGLPSWLRPSSPVFERKAAGALNLQLSFLAVKLCLSRIALLEIHRSNESPAEEDKLYYRSRCRKAARTVIDFTVNLARDELHAFWLPYTAYHFTSAATLTLRCALEAENADTAQECIASAKKLIDFLRRIKNEVNWDLADICLGQCEAVVEKLCDTEYLEMWRKNPHPHSQGEYALDRTQPGHGVNAPSFHFAAHNNVPNPEGQDEFIIQQAQTNQAMADDIGINGIGDPSFLQTFMTFGSMPGLMAESPPFPDLWQMPYMDEYGSRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AS85</accession>
    <accession>C8V9I4</accession>
    <name>Q5AS85_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_08845</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF77894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_682114.1">
        <property type="nucleotide sequence ID" value="XM_677022.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AS85"/>
    <dbReference type="STRING" id="227321.Q5AS85"/>
    <dbReference type="GeneID" id="2868432"/>
    <dbReference type="KEGG" id="ani:ANIA_08845"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN8845"/>
    <dbReference type="eggNOG" id="ENOG502SC1U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_591800_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AS85"/>
    <dbReference type="OMA" id="YATPMRT"/>
    <dbReference type="OrthoDB" id="2142961at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016071">
        <property type="term" value="P:mRNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028322">
        <property type="entry name" value="PNRC-like_rgn"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35361">
        <property type="entry name" value="OS08G0443700 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35361:SF1">
        <property type="entry name" value="OS08G0443700 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15365">
        <property type="entry name" value="PNRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="114"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="379"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF77894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="465" mass="50824" checksum="75BC7CA3B340268C" modified="2005-04-26" version="1">MPTQSPTPLTPKDSRNNRRNQKRNITASAQNVSALATPPSSPPKAVSPREATTDSSSAIIFKKKGNRSAKKLRDISRMSPVNKPGHRHTSSQSNNNIATSHMKETHYAGPTFHASPAPSALPIPSFFSKSFPESDLAPAFEQDSDSFDADGDLENTPSKPRSRPLLSHEQRESTPLDFLFKAAVEARMSGPQQSPDQSPCFRSPQTDSKAMQHRKFNNDNAGIFPLEMGGSDLNQPQIGPSFAPSYKDRMNALQSASSVSPDLHSLDENERKAKTEALKSLLLNPRPQRPSLTSQSHHDQFNYKRERPILSPMVPHFATPLRTSSGPPVMTSNGDMLDKGSSVSKFGPRQSTHDTHSSSPQRQYLPDSTILANGILASNPGNAPTTPRQAYNLPSRVYPSEMPAPRQHANYYPAFDTKSPAFQPPPANASSPAVDTKKIEDDLRRILKLDVNPSIPSSEIQSSLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ASF1</accession>
    <accession>C8V9Q9</accession>
    <name>Q5ASF1_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">5-oxoprolinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ANIA_08779</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxoprolinase family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF78035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_682048.1">
        <property type="nucleotide sequence ID" value="XM_676956.1"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5ASF1"/>
    <dbReference type="GeneID" id="2868386"/>
    <dbReference type="KEGG" id="ani:ANIA_08779"/>
    <dbReference type="eggNOG" id="KOG1939">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002157_0_0_1"/>
    <dbReference type="InParanoid" id="Q5ASF1"/>
    <dbReference type="OMA" id="ANMIKMV"/>
    <dbReference type="OrthoDB" id="3643at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017168">
        <property type="term" value="F:5-oxoprolinase (ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008040">
        <property type="entry name" value="Hydant_A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002821">
        <property type="entry name" value="Hydantoinase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003692">
        <property type="entry name" value="Hydantoinase_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045079">
        <property type="entry name" value="Oxoprolinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365:SF26">
        <property type="entry name" value="5-OXOPROLINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365">
        <property type="entry name" value="5-OXOPROLINASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05378">
        <property type="entry name" value="Hydant_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01968">
        <property type="entry name" value="Hydantoinase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02538">
        <property type="entry name" value="Hydantoinase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydantoinase/oxoprolinase N-terminal" evidence="5">
        <location>
            <begin position="23"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="Hydantoinase A/oxoprolinase" evidence="3">
        <location>
            <begin position="220"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="Hydantoinase B/oxoprolinase" evidence="4">
        <location>
            <begin position="743"/>
            <end position="1286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBF78035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1322" mass="142624" checksum="736C2679A6E56663" modified="2005-04-26" version="1">MTVPLRAPGDPRENKTPRLTFTDRGGTFTDVWASLPGQPDVVLKLLSVDPANYADAPTEGIRRVLSLYYGQEIPRGVPLPKGELESIRMGTTVATNALLERKGTKHAFLVTKGFRDLLEIGYQSRPRLFDLNIVKPEVLYSESSSGDMIRILKPLDETTVRQTLRELRAQGFDTLAVCFTHSHVFPHHENRVERLALDEGFKHVSLSSGVAAKMIKMVPRGSSSSADAYLTPEIKTYLTGFAKGFEGGNLDGVCCDFMQSDGGLVSHDRFSGLRGILSGPAGGVVGFARTSYDASSGTPVVGFDMGGTSTDVSRYGGTFEHVFESNTAGITIQSPQLDINTVAAGGGSILFWRSGLFVVGPESASSHPGPACYRKGGPLTVTDANLFLGRLIPDLFPKIFGETEDQPLDVDIVKKKFVALTAEINRDTGKALTPEEVACGFLNVANEAMCRPIRALTEGKGYDIASHNLAVFGGAGGQHACDIARTLKISTIVIHRFSSILSAYGKTPHRFYPTILPPELTKIGMALADVVEEAQEPVNEIYNERSRQELEERLSKLRGRVGKQLLDQGIAADDISYEMYLNMRYQGTETSIMVLRPDNGDFAAEFRRTHLREFSFCFPDKKPIYVDDVRVRGIGASERKDWEGDQLGQQLRETTFRPPAKGYLGRLLTNQVYFPKLGYQDTPVYLVQNLPAGLSIDGPAIIVDQTQTLVVAPNTVAKVLRSHIVIEVLSTASAVTEQPTTVDHIQLSVFGHRFMSIAEQMGRALQKTAVSLNIKERLDFSCALFGPEGDLVANAPHVPVHLGSMSYAVKHQHELHKGKLVPGDVLVTNHPEAGGTHLPDITVITPVFENTGSKVAFYVASRGHHTDIGGLGGTSMPPNSTELWQEGAAIRSFKLIHGGDFDEKGITEILLSSGEYTGCTGSRHIQDNLSDLKAQVAANHKGVTLVQALIGEYTLPTVQLYMGAIQSNAELAVRSYLTTVRERLGPHLTATDQMDNGTLIRLSVSISPDGSATFDFTGTGVEMLSNINAPPAITHSAIIYTLRLLIGTDIPLNQGCLAPINTIIPKGSFLNPSSGPAVCAGNTQTSQRVVDVILRAFRAAAASNGCMNCLGFFGGDSDGTEPGSKLEGFSYAFGETICGGSGATSTQNGASGVHCHMTNTRITDPESLEKRYPVILREFAIRRGTGGKGMHDGGDGVVRDIECRAPLSFSVITERRSVPPYGMEGGAEGERGANYWVKRVKGGEGNRAEAADQWRWVNMGAKNMVRMQPGDRCVIHTPGGGGWGVPGLSNGNSKEDVPRVQQQYPRASGSVIAYAAAQEASN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ASW6</accession>
    <accession>C8VAF4</accession>
    <name>Q5ASW6_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cupin domain protein (AFU_orthologue AFUA_3G13620)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_08614</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF78324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_681883.1">
        <property type="nucleotide sequence ID" value="XM_676791.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ASW6"/>
    <dbReference type="STRING" id="227321.Q5ASW6"/>
    <dbReference type="GeneID" id="2868490"/>
    <dbReference type="KEGG" id="ani:ANIA_08614"/>
    <dbReference type="eggNOG" id="ENOG502SDZY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_120069_0_1_1"/>
    <dbReference type="InParanoid" id="Q5ASW6"/>
    <dbReference type="OMA" id="IVDYPPG"/>
    <dbReference type="OrthoDB" id="5793281at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="CDD" id="cd02234">
        <property type="entry name" value="cupin_BLR7677-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38599">
        <property type="entry name" value="CUPIN DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_3G13620)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38599:SF1">
        <property type="entry name" value="CUPIN DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_3G13620)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin type-2" evidence="1">
        <location>
            <begin position="54"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF78324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="150" mass="16421" checksum="617F2BF178FB3F6F" modified="2005-04-26" version="1">MSIPKVSASDIKVVKSGDTYQVEGFYARRPRESFEIIKIYHPSNLPGKQIVVGRVLMDPRAATPPHTHSGAAIVAVVTEGTVLNQMNEDNPILTSKGEVFYESPGCHHVLSENNTQEKASFIVVLIVDDEVVKDGYESLVVLDAEKQDGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="106" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ASX0</accession>
    <accession>C8VAF9</accession>
    <name>Q5ASX0_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ANIA_08610</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF78333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_681879.1">
        <property type="nucleotide sequence ID" value="XM_676787.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ASX0"/>
    <dbReference type="GeneID" id="2868561"/>
    <dbReference type="KEGG" id="ani:ANIA_08610"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_1_1_1"/>
    <dbReference type="InParanoid" id="Q5ASX0"/>
    <dbReference type="OMA" id="WMPIQIY"/>
    <dbReference type="OrthoDB" id="5296287at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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    <dbReference type="GO" id="GO:0140115">
        <property type="term" value="P:export across plasma membrane"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
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    <dbReference type="GO" id="GO:0042908">
        <property type="term" value="P:xenobiotic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000460">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
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    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
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    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
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    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF33">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="318"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="357"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="398"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="423"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="85"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBF78333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="456" mass="49895" checksum="57ABE17C880CC8EB" modified="2005-04-26" version="1">MASQSTLRPSLSRDASLDRKDKRLPAESGLQVDLEKTPTTTSVKREPSTRTVHPETDLDRGIVGWDGQDDPANPMNFAPSRKWTLLGLVSAVTFISPLASSIFSPALEDLALDMRITNETLLSFTVSIYLLGYTFGPMLLAPLSEIYGRRIVLSCANWFFVVWQIGCALAPNLASLIIFRLLAGVGGSGCITLGAGVIADLFPVQQRGLATALWSLGPLMGPVVGPIAGGFVGESIGWRWVFWLLLIAGGALSIAIECFNKETYAPVLLRWKTAKLSKELGRSDLRSVYEAEGQTESPGQVLKLGLKRPIVLLCKSPIVLFVSTYIALLYGLLYLFFTTIPTTFGDQYGFSPGLSGLSYLGIGIPEFIGLAIIGLTSDKILLRLATRNGGKFEPEMRLPAMVFWSCWIPISFFWYGWAAEKKAHWIVPILGMAPFGLGLMGAWMPIQIYIIDCYPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="123" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AT04</accession>
    <accession>C8VEU9</accession>
    <name>Q5AT04_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="2">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">ANIA_08576</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.49" evidence="2"/>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF80836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_681845.1">
        <property type="nucleotide sequence ID" value="XM_676753.2"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q5AT04">
        <property type="interactions" value="22"/>
    </dbReference>
    <dbReference type="GeneID" id="2868726"/>
    <dbReference type="KEGG" id="ani:ANIA_08576"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN8576"/>
    <dbReference type="eggNOG" id="KOG0017">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000384_38_1_1"/>
    <dbReference type="InParanoid" id="Q5AT04"/>
    <dbReference type="OMA" id="LEASWIC"/>
    <dbReference type="OrthoDB" id="4499277at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000063">
        <property type="entry name" value="Zinc knuckle domaincontaining protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025676">
        <property type="entry name" value="Clr5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14420">
        <property type="entry name" value="Clr5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="12">
        <location>
            <begin position="670"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="domain" description="Chromo" evidence="11">
        <location>
            <begin position="1378"/>
            <end position="1438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="266"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="519"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="219"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="270"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="292"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CBF80836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="1451" mass="166870" checksum="F514EA24642FB190" modified="2005-04-26" version="1">MPRPSINLEPYREEISTLYKSGKSPPTIAMILGDRYGIQVSERTIKTHLSIWGIRRANRTASSDIVLHARITVLLFQVGLSEDEIVYILQQEGWNIQPRTLKHVRYQQGLLRRTVNPTADQAEVERVLNQLRADLATGQIEGNGVGIVYHHSKQGFQIGRWLYCYGSFAYTRTLDLSDSAKACAVLKAVSHLQDFLTTTILLSPFFFSDSFFMRRPFTMTMEEESVTLLLQQLQELRTEMRTQKQQLQEENNSLRAELQAVRNSQLRNHPPVTTTVTSATPTPYERSYPRPRHPDVEPFTGEDPKDYPPFQMNLRTKFAIDAACYPTEEEQVYYAYSRLRGKASQRVLPWLLARQKSETPVLWAEFSAVLDKAFGDPDRQRKALVRVNTIKQGRRDFEEFLNEFDEELLNAGGINWDDNQKKALLDTAINVELLKAMVGIRQEDSYDNYCNQLREINHNLQRVARLTRKGSHAAVPMHVARTRPAGGSDRTGTPDQMDWEATHAQIAALQKEVAALRMKGTRTPRKASQAPAEEKQKRLSEGKCLRCGDPDHFVQLDIGAHTEKGAYFYVIPDNLGYDLILGLPWLEQHDGRLEAKRGRLYLRTTGVRLWSTTKRPLPKLDIAQISAATMGGFIQRKRCHGQDIEIFAVSLADIQKALAPKRHIDPRTKLPRQYWKYLRLFEQDKAEELPPHRGDGIDHKIELKGFIRVSHSPAAAPVLFKDRYPLPLIHETLNQIGQARWFTKLDVSAAFHKIRIAKGQEWMTAFRTRYGLFEWLVTPFGLANAPSTFQKYINWTLREYLDEFCSAYIDDVLVYTNGDLRQHRKHVRMVLKKLEEAGLYLDIKKQGRESKWTRRKVKAIKEWETPTTIKGVRGFLGFANFYRRFIPNFSGIVRPLNNLTKKGTPFLWTKECQDSFDLLKEKFITGPVLATFNPSYPECNYEIYDKELLAIVRCLEAWDAELRSCGEFQVITDHKNLEYFFSPRKLTERHVRWSLFLSRFNFKLVYRKGSANQRADALSRRDQDMPDDKDDRVKSRTMQLFSKKHLGKMVVATLQPTGEPPREPCEKGDMWKEALKQDKGYNEAIQCLKDGARKFPPHLQLKVGTSECQLDAQGYILFRGRRWVPGSEQLRTNIIQAAHDSMLTGHPGREQTYMLVSRINRRLSTAHHPQTDGSTERMNSTVETYLRIYTCYDQRDWNRLLPLAELAINGRTSTATGVSPFYLSHGYNLSPFSPTEEVEQLAEEPAKSPIQKGEAIVRKVKEALDWAQASMAYSQQNAENQANKHRSPATNYQVGDKVWLSLKNICTDRPSKKLDWKNAKYEVIGLVGSHAVRLNTPPGIHPVFHVDLLRLASSDPLPSQKNDDTQPPGIIVNGEKEYMVEKILDERPRRYGRGHRLEYLVKWSGYARPTWEAATALEEAQALDEWLDRTKQYRLQDGSLNRDAYIKAKAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ATJ3</accession>
    <accession>C8VE86</accession>
    <name>Q5ATJ3_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_08387</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF80437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_681656.1">
        <property type="nucleotide sequence ID" value="XM_676564.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ATJ3"/>
    <dbReference type="GeneID" id="2868633"/>
    <dbReference type="KEGG" id="ani:ANIA_08387"/>
    <dbReference type="HOGENOM" id="CLU_1461296_0_0_1"/>
    <dbReference type="InParanoid" id="Q5ATJ3"/>
    <dbReference type="OMA" id="RSREYHY"/>
    <dbReference type="OrthoDB" id="4445556at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF80437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="185" mass="20589" checksum="3FF0E7335DD46E32" modified="2005-04-26" version="1">MHWVSGTWLWAKHKASRSTSSGAPIYLEQSKGTSERRNRPRTWSLPTNPPDDTSTASSRSRGSSYSQSHGYSHGHTHSLHRVETYNQAQYNNPLAVAQLRCIRCGGLRSREYHYRHFDDPVKYPSVGICSRQRTRCARAKSDPVPLAAMDPPATAVAPVFDIPELPDTSTSRPKTASGEIEPDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="119" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ATQ0</accession>
    <accession>C8VE21</accession>
    <name>Q5ATQ0_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alcohol dehydrogenase, zinc-containing, putative (AFU_orthologue AFUA_5G10220)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ANIA_08330</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF80320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_681599.1">
        <property type="nucleotide sequence ID" value="XM_676507.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ATQ0"/>
    <dbReference type="GeneID" id="2868756"/>
    <dbReference type="KEGG" id="ani:ANIA_08330"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN8330"/>
    <dbReference type="eggNOG" id="KOG1198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_16_5_1"/>
    <dbReference type="InParanoid" id="Q5ATQ0"/>
    <dbReference type="OMA" id="YCKMPAA"/>
    <dbReference type="OrthoDB" id="9992527at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035925">
        <property type="term" value="F:mRNA 3'-UTR AU-rich region binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070402">
        <property type="term" value="F:NADPH binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003960">
        <property type="term" value="F:quinone reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C2E1P3.01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="3">
        <location>
            <begin position="15"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBF80320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="352" mass="36957" checksum="BD5C7BEB4707367D" modified="2005-04-26" version="1">MSVPSSFRAALLHEKSPEHTIAERSLGPLGSDEVAIKVTATAINPVDWKIRDYSVFLTSYPAVLGSDAAGEVVAVGDSVQNLAVGDRVFFQGIIRNYDASTFQQYCKMPAELVGKTPKAISDQQAAGISLATIAGITGLYDKTGRGLAPPPWEQGGDRAGSGNALVVLGGSSSVGQYVIQLARLSGYDRIVTNSSLTHEAHLKELGAHVVLDRKQAGPQDFVAALNGLPLDFVFDAISNADTQKLGVEILNSAGIESQVVVVQAVNSEAKELGASKSLKIDVRQVLGLGSSPDLRYLSVPLMKSLGGEDGWLATGKFTPNRPVIVEGGLGKIDEALDKNRAGVSGEKVVILP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ATZ3</accession>
    <accession>C8V7F9</accession>
    <name>Q5ATZ3_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_08237</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF74175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_681506.1">
        <property type="nucleotide sequence ID" value="XM_676414.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ATZ3"/>
    <dbReference type="STRING" id="227321.Q5ATZ3"/>
    <dbReference type="GeneID" id="2869140"/>
    <dbReference type="KEGG" id="ani:ANIA_08237"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN8237"/>
    <dbReference type="eggNOG" id="ENOG502S7WN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030520_1_0_1"/>
    <dbReference type="InParanoid" id="Q5ATZ3"/>
    <dbReference type="OMA" id="DERTMTM"/>
    <dbReference type="OrthoDB" id="5385072at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="102"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="235"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF74175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="359" mass="38946" checksum="E0D35BF31CB943F3" modified="2005-04-26" version="1">MTDYRLPMHQIPSRKPVPSAHSGPQFQAYHHNAYQQQQYQPHQQAQQLFPHPSVASLAHSRNRTTSSNVLPYAGHPQHHHPQQPYTTGPSPQHSMTVPYNPLARRLSSATTSTTSTGNNGDVRRSTSSRSAGSQMSYVALLRRQKATVWCDRAQAEDPRLRQQKLVDKKRAYLEVHGAGAGRASTLGSGKGKHGNKVTELSPSALVGATVPVRLSANEVGDADDDARSDRDFPYRRTGSGRSSLGSGHRYPSGYQRNTASSGNTPPNEKTDLPGVSEDKAGEQKDTNIAKDDGATTNSRNSEQEDSFGTVGDMGAPNAATLAEQKAKKAADLRRRGSVDDRTTSMTNVRLFVANPDLSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="103" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AU74</accession>
    <accession>C8V6W6</accession>
    <name>Q5AU74_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Altered inheritance of mitochondria protein 9, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Found in mitochondrial proteome protein 29</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ANIA_08156</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AIM9 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF73997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_681425.1">
        <property type="nucleotide sequence ID" value="XM_676333.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AU74"/>
    <dbReference type="STRING" id="227321.Q5AU74"/>
    <dbReference type="GeneID" id="2869307"/>
    <dbReference type="KEGG" id="ani:ANIA_08156"/>
    <dbReference type="eggNOG" id="ENOG502SIYK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019189_3_0_1"/>
    <dbReference type="InParanoid" id="Q5AU74"/>
    <dbReference type="OMA" id="QGSIDRH"/>
    <dbReference type="OrthoDB" id="2831558at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051035">
        <property type="entry name" value="Mito_inheritance_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091:SF1">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBF73997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="653" mass="73585" checksum="DB868B3DE64CA238" modified="2005-04-26" version="1">MSKVLGSFVQKAQSLKNAPSKFSSAAVEGSRLIPSRTKDADFQLRIDAGHYDPDSKKVNVALQVNSQAESPVLKEWVKKNTTHANLATSVFDTAAEDKQAEYERMLRTLRHPLFRAFQSRLGRPSSIPLFPSTALPSRLQAASGATISTERRMDTELEMEVKPYTYTSGRWLRQDKMETDSRYIQFSFIALCQKVIELCPEANHIKACRKIEGGFNRVFIFTLDNEKAIVARLPFRLAGPAKLTTLSEVATIRYLQTKTNIPIPRVLDYNGDASDETNMIGSEYIIMEHATGVPLHEKWHKMAGDQQVRCIDAIYRTMKDIVDLEFPAFGSIYFDDTLGPASKQPLGDGFCVGPHCGTRYWDTNVGERRYYHYVNRNTGPWLTIGEYCDGLIDAGLSQVPPVDIESKRPIYHGSPEAHLALLECTRPVLKQMATDSRISNSAAPLLFHPDLHMRNIFVSDDNPSAITSIIDWQAASIEPAFWYSDEVPDFAVGSEICAKAFDLSSQFFTPKLAGPRLMNDNIFRPFHYCYRTWKDGAVALHYEMTETARLWNKLGFEGQCPFPLPTRDELEKQEKEYRLFEAAQNLRTDLASLLNTASDGWVPPDGWKAAQSAQKELFDGMLQAVLTNAGSDDDEPVRDEMTLRSIWPFDIDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AUD7</accession>
    <accession>C8V6F5</accession>
    <name>Q5AUD7_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CCCH zinc finger DNA binding protein (AFU_orthologue AFUA_5G12760)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ANIA_08093</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF73870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_681362.1">
        <property type="nucleotide sequence ID" value="XM_676270.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AUD7"/>
    <dbReference type="STRING" id="227321.Q5AUD7"/>
    <dbReference type="GeneID" id="2868894"/>
    <dbReference type="KEGG" id="ani:ANIA_08093"/>
    <dbReference type="eggNOG" id="ENOG502SM7V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031811_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AUD7"/>
    <dbReference type="OMA" id="FIRGFNM"/>
    <dbReference type="OrthoDB" id="2270193at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057683">
        <property type="entry name" value="DUF7923"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057654">
        <property type="entry name" value="Znf-CCCH_tandem"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37543">
        <property type="entry name" value="CCCH ZINC FINGER DNA BINDING PROTEIN (AFU_ORTHOLOGUE AFUA_5G12760)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37543:SF1">
        <property type="entry name" value="CCCH ZINC FINGER DNA BINDING PROTEIN (AFU_ORTHOLOGUE AFUA_5G12760)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25540">
        <property type="entry name" value="DUF7923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25543">
        <property type="entry name" value="zf-CCCH_tandem"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7923" evidence="2">
        <location>
            <begin position="95"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="Tandem CCCH zinc finger" evidence="3">
        <location>
            <begin position="396"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="25"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBF73870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="431" mass="48166" checksum="5394A2FD9B97BC9D" modified="2005-04-26" version="1">MIDPAVLRRQHDELCKAESSKDEIIKNLFEHIEDLEEKLQIEKNEVDSQRRAVISLRDERNEFKAQMEDLVDEKAPDAAIQRDMHLSREATTPNRYQFQDRFIQDGKKGGHDAAQALIYAVQEHIKEIDPKASPIINCNIRVYSNVHGLTKVYRETGIIRSDSDLSAFIRGFNMENPLCDFVDAGNGKECADVKIKGLFAEDINNVHCRRIIFCASADSGYARVLGPHRGSRRISIVKGPPFPREMAELAASFETVTFSDVFKSSKLLLPVRKLSSQDITSPAIASANMPAIVHNHNSIPNYASAAKAAAAATIAPTKDSKTKSESKPRLLVCLNARNQRVDSVLKKSSKEAITALKRRKLCNQFHILGYCHNMATYGSCTHEHGTELSMQELNDLMRVARLTPCFSGLMCRDVNCISGHQLIVNSRICTT</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2010-05-18" modified="2026-01-28" version="104" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AUW5</accession>
    <accession>C8V4V5</accession>
    <name>BGLD_EMENI</name>
    <protein>
        <recommendedName>
            <fullName>Probable beta-glucosidase D</fullName>
            <ecNumber>3.2.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Beta-D-glucoside glucohydrolase D</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Cellobiase D</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Gentiobiase D</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">bglD</name>
        <name type="ORF">AN7915</name>
    </gene>
    <organism>
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Beta-glucosidases are one of a number of cellulolytic enzymes involved in the degradation of cellulosic biomass. Catalyzes the last step releasing glucose from the inhibitory cellobiose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text>Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <comment type="sequence caution" evidence="4">
        <conflict type="erroneous gene model prediction">
            <sequence resource="EMBL-CDS" id="EAA59569" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EC" id="3.2.1.21"/>
    <dbReference type="EMBL" id="AACD01000135">
        <property type="protein sequence ID" value="EAA59569.1"/>
        <property type="status" value="ALT_SEQ"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF73514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AUW5"/>
    <dbReference type="SMR" id="Q5AUW5"/>
    <dbReference type="STRING" id="227321.Q5AUW5"/>
    <dbReference type="CAZy" id="GH3">
        <property type="family name" value="Glycoside Hydrolase Family 3"/>
    </dbReference>
    <dbReference type="GlyCosmos" id="Q5AUW5">
        <property type="glycosylation" value="9 sites, No reported glycans"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CBF73514">
        <property type="protein sequence ID" value="CBF73514"/>
        <property type="gene ID" value="ANIA_07915"/>
    </dbReference>
    <dbReference type="KEGG" id="ani:ANIA_07915"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN7915"/>
    <dbReference type="eggNOG" id="ENOG502QR4D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004542_2_1_1"/>
    <dbReference type="InParanoid" id="Q5AUW5"/>
    <dbReference type="OMA" id="WVLNDTY"/>
    <dbReference type="OrthoDB" id="416222at2759"/>
    <dbReference type="UniPathway" id="UPA00696"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0000270"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000757">
        <property type="entry name" value="Beta-glucosidase G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1700:FF:000021">
        <property type="entry name" value="Probable beta-glucosidase D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF14">
        <property type="entry name" value="BETA-GLUCOSIDASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword id="KW-0136">Cellulose degradation</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0326">Glycosidase</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0624">Polysaccharide degradation</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000394108" description="Probable beta-glucosidase D">
        <location>
            <begin position="19"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="186"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="191"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="211"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="236"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="324"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="188"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="296"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="360"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="384"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="422"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="501"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="592"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="646"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="812" mass="86383" checksum="A70CFB5FF35CBD1B" modified="2010-05-18" version="2" precursor="true">MRVPSLSVLSFLLGTALAAASNFEAGLLSSGKVSLGDWKSAHEKASQFVAKLNTTEKIKLITGSSVTTTNGETFTALDILDGDMGAQAYYYVSAFSLSSALAMTWDKEAMYEQGRAIAAEFYGKGIQMVAGPTSQPLGRTPWGGRLVESFGPDPYLNGIATGLETRAYADVGVIAGAKHFILNEQETNRTGGMGGGGGAPGGGGMGRGAEFSSSVPGGMSPTSSAGAIPSSTSTPGGSGMGGGMAGSSAFSSSSSSGAPYSSNADDKTLHETYLWSFYDAVHSGLGGVMCAMTKVNGTLSCQSSSLLLDILKTELGFPGMVWPDTNGQQDALASAANGLDYGSSSLWSESTIEGYLESNNITEARLNDMAIRNLMGYYYVNLDNGTQPSTAAQDDYVDVRANHAKLIRSHGSKSMVLLKNKNNTLPLYKPHKMAIFGSHARAAVAGPNMQFSVEGSGPTYDGHIATDSGSGQASLPYLITPENALNIKASQDGTMLRWIANDTYSSSTGSALVMQGSSSTSVTPSVSAYSENMDVCLVFINALAGEGADRTELRNTDQDNLINEVADNCDNTVVVINTVGARILDSWIEHENVTAVLYGSLLGQESGNSIVDVLYGDVNPSGRLTYTIAKTESDYNVDICYTAQCNFTEGNYIDYRYFDAYNVTPRYEFGYGLSYTDFAYSNLHIQGPSALSTYPTGQLAVGGYEDLWDTVAKVTVTIRNAGSLDGAEVPQLYISYPDVAKQPVRQLRGFHNVYIKKGQSTKVTFELRRRDISYWDVQHQKWAVAPGTYEAWVGASSRDLRTHGSFVVKTKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AVG6</accession>
    <accession>C8VDH7</accession>
    <name>Q5AVG6_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_07714</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF79959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_680983.1">
        <property type="nucleotide sequence ID" value="XM_675891.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AVG6"/>
    <dbReference type="STRING" id="227321.Q5AVG6"/>
    <dbReference type="GeneID" id="2869466"/>
    <dbReference type="KEGG" id="ani:ANIA_07714"/>
    <dbReference type="eggNOG" id="ENOG502QRU3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010014_4_1_1"/>
    <dbReference type="InParanoid" id="Q5AVG6"/>
    <dbReference type="OMA" id="MWRYGVH"/>
    <dbReference type="OrthoDB" id="2017974at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005697">
        <property type="term" value="C:telomerase holoenzyme complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070034">
        <property type="term" value="F:telomerase RNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000202">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.7, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045153">
        <property type="entry name" value="Est1/Ebs1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15696">
        <property type="entry name" value="SMG-7 SUPPRESSOR WITH MORPHOLOGICAL EFFECT ON GENITALIA PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15696:SF0">
        <property type="entry name" value="TELOMERASE-BINDING PROTEIN EST1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF79959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="787" mass="88185" checksum="1E35C8B5D2EF3DCC" modified="2005-04-26" version="1">MSDKSVSAGRETLPVRRRYSGDRDLNAKQPAGTAGSDAALEGSSSPGRTPMALASEDGSMNSNRAQYSATFSYTNTRTDDLNSNPASDNVVELAASHLRQGLRPPRKAQGSRSGAPRSRPVSRPGADSWTGKASAGSESRLRYSVNSTDDVGSADGGTSRLQHQQLHSNSGSNDGRFPVTGVARQNEIGSLSRASGQPTEDSSYGQESAQRLSNEQRPAGGVFAADGGTASSRLLLQVDTKPLTEEELRNETQAIYSGILMAEKKCIELFKHHFQKNTELSQQEWQMLVSLHRVLLEEYHAFFLASQQQAAGPAVNRLAEQYAMPSRLWRYGIHSLLELLRHRLPGSLERILAFFHLAYGYMTVFLEFVPKFEDTWLECLGDLSRYRMLVEDADIREREGWAEIARHWYNKAADRNPDIGRIQHHLAPLARPDFVQQLFYYTKSMVCVHPFGGTRDSILHLFNPVLKAPETLGGLKEIVAAFVAAHGYLFKGELGNPFERACFDFLSILELYIGRLGPTFKAQGVYISSCNFAAVLEYGAPNALLPREFLTNAAQSKSMDDIYFASHRFWTPVGDLKTIEADFLASRNSDTISPVVFYAACFTFQTLSIMLDQTGNKNVYPSFHASLAFLWSLARTPTSMKRVEVIVPWQQIATFLNTLTRNFTDFTLIEGTDFPSQGDDRWLFEDFLIRGQVWSQNLYPTDFFDKAPTVDDGRNLEPPSRDLSRMHRCLWLGVRLAKFNRWMTYDAASRRFMATEFASDLDKMAREHSPFYGKGLQTESNLEMHDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="99" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AVL5</accession>
    <accession>C8VC22</accession>
    <name>Q5AVL5_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Exosome complex subunit Rrp46, putative (AFU_orthologue AFUA_2G01330)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ANIA_07665</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF79860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_680934.1">
        <property type="nucleotide sequence ID" value="XM_675842.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AVL5"/>
    <dbReference type="STRING" id="227321.Q5AVL5"/>
    <dbReference type="GeneID" id="2869404"/>
    <dbReference type="KEGG" id="ani:ANIA_07665"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN7665"/>
    <dbReference type="eggNOG" id="KOG1069">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063514_2_2_1"/>
    <dbReference type="InParanoid" id="Q5AVL5"/>
    <dbReference type="OMA" id="SYKCPAT"/>
    <dbReference type="OrthoDB" id="27298at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.70:FF:000036">
        <property type="entry name" value="Exosome complex subunit Rrp46, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050080">
        <property type="entry name" value="RNase_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953:SF1">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0271">Exosome</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBF79860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="248" mass="25926" checksum="263F3B315FB5A911" modified="2005-04-26" version="1">MAGPVADLHPLSRSDGSASYKCPFTGSNILGSVNAPIELPGRRDALKPEEATIEVFVKPGTAPGGVGERYVEGIVRSALGRVILGREKGYPRRGVVITLAIVGGEGVARGGSYLPLLPALLHTATLALLSASVPLSVTLSATILAVDPAGKIIREPSTKEAKAAASLHVLAFTSKGHLLLNESEGAFTYDTWEAVYERALVICLGSSALSSDGDVAMAESTESQPLEGILRDTVEDHIHSEYSWKLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="124" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AVY1</accession>
    <accession>C8VBN5</accession>
    <name>Q5AVY1_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="17">BCS1-like ATPase, putative (AFU_orthologue AFUA_2G14760)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">ANIA_07549</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="18">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AAA ATPase family. BCS1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF79612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_680818.1">
        <property type="nucleotide sequence ID" value="XM_675726.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AVY1"/>
    <dbReference type="STRING" id="227321.Q5AVY1"/>
    <dbReference type="GeneID" id="2869406"/>
    <dbReference type="KEGG" id="ani:ANIA_07549"/>
    <dbReference type="eggNOG" id="KOG0743">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010189_4_1_1"/>
    <dbReference type="InParanoid" id="Q5AVY1"/>
    <dbReference type="OMA" id="YLMFWMA"/>
    <dbReference type="OrthoDB" id="10251412at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034551">
        <property type="term" value="P:mitochondrial respiratory chain complex III assembly"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032979">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane from matrix"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057495">
        <property type="entry name" value="AAA_lid_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014851">
        <property type="entry name" value="BCS1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050747">
        <property type="entry name" value="Mitochondrial_chaperone_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23070">
        <property type="entry name" value="BCS1 AAA-TYPE ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25426">
        <property type="entry name" value="AAA_lid_BCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08740">
        <property type="entry name" value="BCS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01024">
        <property type="entry name" value="BCS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="BCS1 N-terminal" evidence="16">
        <location>
            <begin position="60"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="15">
        <location>
            <begin position="309"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="377"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="591"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="383"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="394"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="603"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="622"/>
            <end position="634"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CBF79612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="650" mass="72134" checksum="8596D3734D6E0382" modified="2005-04-26" version="1">MASAPTMANATTFNTTPMQTLLNPSDTALLETFIPGYSMASRILSTYLQIDLSSYIPYLIFMGLIAATARYIYSQLYNLFQEHCISTAEIRHDDEVYNYLMYWLAQQPFTNRTTHFVAGTRISGSSWCYEPDSDSDEEGFGGADEIDNEGNVVTDFDAYWAKATARDKLKKLRFTPSEGTHYFWFNGRPLAFIREKQDDKSSGGGYYGYGTKAPERLYISCIGRDPAVLKELLLEAQRYYVAKDKNNTVIYRGHKSGSYTEWSRCMARAPRALSTVVLDKAQKDAFIDDIKDYLHPRTRRWYNNRGIPYRRGYLLHGPPGTGKTSLCFAAAGLLGLELYLLNLSSKSLDEDELMALFTDLPTRCIVLLEDVDCAGMSQKRTPGSSSNDDNGNSASPELQEQGEGNSSGTTTGGTGVFEKQGVSLSGLLNVIDGVAACEGRILVMTTNHPEKLDPALVRPGRIDLSIAFGHSTTSDIKELFSAIYSTLEGDLRVSPAERLSPKLRARMAKRSSTSHSTNSTNANVVIHKETRKFSEEQIRLWAAEFAERVPAGEFTPAEIQGYLLNHKTDPERAIEEATRWVGEVKEKKAKTKAKSASANTAKVDGDQEEDKREVNGVKNEGKTQLTNGDAQAHTNMDKPCPTSICRETTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AWK8</accession>
    <accession>C8VCN1</accession>
    <name>Q5AWK8_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">GPI anchored protein, putative (AFU_orthologue AFUA_6G02800)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ANIA_07322</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
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            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
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    <dbReference type="SMR" id="Q5AWK8"/>
    <dbReference type="GeneID" id="2870045"/>
    <dbReference type="KEGG" id="ani:ANIA_07322"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN7322"/>
    <dbReference type="eggNOG" id="ENOG502S3DR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="OMA" id="PGHECYP"/>
    <dbReference type="OrthoDB" id="2587363at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0098552">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="CDD" id="cd21176">
        <property type="entry name" value="LPMO_auxiliary-like"/>
        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR046936">
        <property type="entry name" value="BIM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046530">
        <property type="entry name" value="BIM1-like_dom"/>
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    <dbReference type="PANTHER" id="PTHR34992:SF5">
        <property type="entry name" value="ANCHORED PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G02800)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34992">
        <property type="entry name" value="HYPHAL ANASTAMOSIS-7 PROTEIN"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF20238">
        <property type="entry name" value="BIM1-like_dom"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
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    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="218"/>
            <end position="244"/>
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    <feature type="domain" description="Copper acquisition factor BIM1-like" evidence="10">
        <location>
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    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF20238"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CBF78620.1"/>
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    </evidence>
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        <source>
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        </source>
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<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AWP9</accession>
    <accession>C8VCS6</accession>
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        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
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            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CBF78705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_675458.1"/>
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    <dbReference type="KEGG" id="ani:ANIA_07281"/>
    <dbReference type="HOGENOM" id="CLU_2250133_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AWP9"/>
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        <property type="component" value="Chromosome IV"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF78705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="104" mass="11667" checksum="91A5797F182B35DC" modified="2005-04-26" version="1">MEEVSPKMFILPGPPLAYLHWPTYTGLPTLADLRFAPGVLWRLGRSGCIQIALRGLLIAFSSSKECYLISTLSLPTWSLELCFLLQIKEVSKLGRLRQFGPAFQ</sequence>
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<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="102" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AWS9</accession>
    <accession>C8VCV9</accession>
    <name>Q5AWS9_EMENI</name>
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        <recommendedName>
            <fullName evidence="4">FAD-binding domain-containing protein</fullName>
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    <gene>
        <name evidence="5" type="ORF">ANIA_07251</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Aspergillaceae</taxon>
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            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF78765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_680520.1">
        <property type="nucleotide sequence ID" value="XM_675428.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AWS9"/>
    <dbReference type="GeneID" id="2870139"/>
    <dbReference type="KEGG" id="ani:ANIA_07251"/>
    <dbReference type="eggNOG" id="KOG3855">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009665_14_2_1"/>
    <dbReference type="InParanoid" id="Q5AWS9"/>
    <dbReference type="OMA" id="RFWHAFP"/>
    <dbReference type="OrthoDB" id="2096480at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050641">
        <property type="entry name" value="RIFMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004:SF21">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004">
        <property type="entry name" value="TRK SYSTEM POTASSIUM UPTAKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21274">
        <property type="entry name" value="Rng_hyd_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="4">
        <location>
            <begin position="3"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBF78765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="581" mass="65096" checksum="7506F9C0572EF617" modified="2005-04-26" version="1">MDLTNSRSMELLRTLGLVNACRAIPGSIAEDVSFECVFVTSLHPENGRELGRWSVPCVAEQTSESKGTNDGSFPAEPGQRCSQILVEKWMRGLVLDCKNVEFRGNWRYVGHAEEEDRVRVRAVDLHGNEHTFVGRFLVGCDGRKSAVRKAAGIEMIGAKVPAHFHLVHFRSRALSSILDRSKSRFWHAFPAGSGFLIDQDGKDTFTAHCPLTEYEARVSSADDRVFPSNLDPKTTIWRVLGGYGVTGECWELPIDEILVDSIWQPSLRIAAAYSTPSFLVFLAGDSAHLSPPHGGYGLNSGIVDAVSLAWRLAAVIKGYGGSYLLSSYSLERRPMMMRALCRSYRHLLEHVKLGSLYEEFGDVIEAEGDEGENVRMYLGRWIAESGPDILDRGVELDLRYEGSPCIWTEPQSEGEEDDAWDVHRYRPSTRPGRRAPHVFLKDGKTSTYDFLGTEWTLMQFITHESESETSKAETLLRTAKQRGFPLQHVLLCGEEQVRRIWRRDLVLVRPDTHVAWRGKGRLAVAEAEMVLDVVLGKSVRPEYTPPTNTEETLFLKTVDQLVSMGKSTGERAGPRDVKARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="113" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AWU2</accession>
    <accession>C8VCX4</accession>
    <name>Q5AWU2_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ANIA_07238</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF78791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_680507.1">
        <property type="nucleotide sequence ID" value="XM_675415.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AWU2"/>
    <dbReference type="STRING" id="227321.Q5AWU2"/>
    <dbReference type="GeneID" id="2870131"/>
    <dbReference type="KEGG" id="ani:ANIA_07238"/>
    <dbReference type="eggNOG" id="KOG2305">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009834_0_1_1"/>
    <dbReference type="InParanoid" id="Q5AWU2"/>
    <dbReference type="OMA" id="MRYALMG"/>
    <dbReference type="OrthoDB" id="2021159at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050104">
        <property type="term" value="F:L-gulonate 3-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48075">
        <property type="entry name" value="3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48075:SF1">
        <property type="entry name" value="LAMBDA-CRYSTALLIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase NAD binding" evidence="4">
        <location>
            <begin position="8"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase C-terminal" evidence="3">
        <location>
            <begin position="197"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBF78791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="327" mass="36039" checksum="DD78BC4C694FA0C0" modified="2005-04-26" version="1">MASHSIQTIGVIGTGVIGSSWTALFLSRGLKVIVTDPAPEAETKLRDYLEKTCPLVPGCTLTLETCLSNLTFVTNIDPYLEIVDFIQESGNLIVVNQNGPERLPIKRSLIAHLDALTPRHIPIVSSSSGIPSSMFIADCKNNPARILIGHPFNPPHLVPLVEIVPHPRTANEHIAAAYDFYKSLDKDPVIVRQETPGFIANRLQAALCAEAYSLIERGVVSPEDLDKTMTSGLGLRWAVTGPVMTNTLGGGGDFGHFMDHLGPALKYWLGDMHKHGFDFESQEKTDDLKKRVSVWVSNLDLSDLERRRDEVSEYSLMLTYSRIITLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AWU8</accession>
    <accession>C8VCY0</accession>
    <name>Q5AWU8_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ANIA_07232</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF78803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_680501.1">
        <property type="nucleotide sequence ID" value="XM_675409.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AWU8"/>
    <dbReference type="GeneID" id="2869998"/>
    <dbReference type="KEGG" id="ani:ANIA_07232"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN7232"/>
    <dbReference type="eggNOG" id="ENOG502SJK4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028200_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AWU8"/>
    <dbReference type="OMA" id="ILYAWNL"/>
    <dbReference type="OrthoDB" id="10017208at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF151">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="93"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="172"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="28"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="329"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBF78803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="386" mass="43859" checksum="871DF422A3E6DD4E" modified="2005-04-26" version="1">MADNDSLQPWTLATVVSVTVLAFVTVALRLLARYERKQKLWWDDWMILWSMVYTPLGNVGWNLIVVAFIFLMYHNGMGLHADTMPPGKVVLVAKYLVVAEVLYVYNLVWTKMSILLFYYRIFRFPYFKRWAYIISTFIVLWVICITFLFIFICVPVEKLWYPQLPGRCINQVATWIANAISTIVTDLAILMLPIPQIWSLQLRSSEKMALTFAFGLGFFVVFASAYRFSVLFSYDPLDSTYTLAPTVGWTAIEMSAGIVSACLPTLRPAFHFFFRILGLQSIMPSLLRTGQSQTTTTNIVGNDVSLGTSKTAQTSAGRANRRSFYHLPDEDDSLESEHGSPPFRPEYDSAHTKIVVQGKGQEGDLTGDEVPLQGIRVQREFTQRDS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-09-13" modified="2026-01-28" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AWZ6</accession>
    <accession>C8VD38</accession>
    <name>CWC26_EMENI</name>
    <protein>
        <recommendedName>
            <fullName>Pre-mRNA-splicing factor cwc26</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">cwc26</name>
        <name type="ORF">AN7184</name>
    </gene>
    <organism>
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CWC26 family.</text>
    </comment>
    <dbReference type="EMBL" id="AACD01000122">
        <property type="protein sequence ID" value="EAA61436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF78908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_664788.1">
        <property type="nucleotide sequence ID" value="XM_659696.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AWZ6"/>
    <dbReference type="SMR" id="Q5AWZ6"/>
    <dbReference type="STRING" id="227321.Q5AWZ6"/>
    <dbReference type="EnsemblFungi" id="CBF78908">
        <property type="protein sequence ID" value="CBF78908"/>
        <property type="gene ID" value="ANIA_07184"/>
    </dbReference>
    <dbReference type="GeneID" id="2869889"/>
    <dbReference type="KEGG" id="ani:ANIA_07184"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN7184"/>
    <dbReference type="eggNOG" id="KOG2654">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024195_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AWZ6"/>
    <dbReference type="OMA" id="GDVQRQE"/>
    <dbReference type="OrthoDB" id="6022at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018609">
        <property type="entry name" value="Bud13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051112">
        <property type="entry name" value="CWC26_splicing_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31809">
        <property type="entry name" value="BUD13 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31809:SF0">
        <property type="entry name" value="BUD13 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09736">
        <property type="entry name" value="Bud13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0507">mRNA processing</keyword>
    <keyword id="KW-0508">mRNA splicing</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0747">Spliceosome</keyword>
    <feature type="chain" id="PRO_0000079603" description="Pre-mRNA-splicing factor cwc26">
        <location>
            <begin position="1"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="120"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="265"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="157"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="91"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="129"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="345" mass="38276" checksum="86D004A7B5BAA13B" modified="2005-04-26" version="1">MTDSEYLAKNYLTADPSPPTDRPKKKRKKTKAAEVESQGLIIADDDPPDLRSTATLSSKENDEYGPVVTGARSAEFRKTKKSNWKTIGSSTNTGTDTATATGPNAGRDEADAILADAMAEEDARRAAGDEDPMVVDQDDNEDDGGLRMESGARAGLQTAEQTAAMVAAQQKKRKAEEAQYKGKQGHAQETIYRDASGRIINVAMKRAEARRLEEEKLIKEAEAKEALMGDVQRAERESRRAALEEAKVMPLARTADDEELNEELKAQTRWNDPAAQFLTKSTGGGRSKTGKPLYKGAFQPNRYGIRPGHRWDGVDRSNGFEKEWFAARNKKERMQALEYEWQMDE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-11-22" modified="2026-01-28" version="103" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AX35</accession>
    <accession>C8VD80</accession>
    <name>SLT11_EMENI</name>
    <protein>
        <recommendedName>
            <fullName>Pre-mRNA-splicing factor slt11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">slt11</name>
        <name type="ORF">AN7145</name>
    </gene>
    <organism>
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in pre-mRNA splicing. Facilitates the cooperative formation of U2/U6 helix II in association with stem II in the spliceosome. Binds to RNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SLT11 family.</text>
    </comment>
    <comment type="sequence caution" evidence="4">
        <conflict type="erroneous gene model prediction">
            <sequence resource="EMBL-CDS" id="EAA61397" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EMBL" id="AACD01000122">
        <property type="protein sequence ID" value="EAA61397.1"/>
        <property type="status" value="ALT_SEQ"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF78985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AX35"/>
    <dbReference type="SMR" id="Q5AX35"/>
    <dbReference type="FunCoup" id="Q5AX35">
        <property type="interactions" value="125"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5AX35"/>
    <dbReference type="EnsemblFungi" id="CBF78985">
        <property type="protein sequence ID" value="CBF78985"/>
        <property type="gene ID" value="ANIA_07145"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AN7145"/>
    <dbReference type="eggNOG" id="KOG0153">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027112_1_0_1"/>
    <dbReference type="InParanoid" id="Q5AX35"/>
    <dbReference type="OMA" id="CPLRVQW"/>
    <dbReference type="OrthoDB" id="10259600at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071006">
        <property type="term" value="C:U2-type catalytic step 1 spliceosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036002">
        <property type="term" value="F:pre-mRNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000396">
        <property type="entry name" value="Putative Pre-mRNA-splicing factor slt11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039171">
        <property type="entry name" value="Cwc2/Slt11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048995">
        <property type="entry name" value="STL11/RBM22-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR RBM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089:SF6">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR RBM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21369">
        <property type="entry name" value="STL11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0507">mRNA processing</keyword>
    <keyword id="KW-0508">mRNA splicing</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0747">Spliceosome</keyword>
    <feature type="chain" id="PRO_0000212427" description="Pre-mRNA-splicing factor slt11">
        <location>
            <begin position="1"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="237"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="155"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="333"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="377" mass="41625" checksum="B0DB1BBE5422333D" modified="2011-11-16" version="2">MPPQIKQDLNRSGWETTDFPSVCENCLPENPYVQMLKEDYGAECKICTRPFTIFRWKADRTARTKRTNICLTCARLKNCCQCCMLDLSFGLPIVVRDAALKMVAPGPQSSINREYYAQGHEKEIEEGRGAVEEYEKTDEKARELLRRLANSEPYYRKPRQLEAPEEDGETQGPSDATVVRSRYGNGPGPVRTSESRRGTPLPGRGRGGVRGGRPFPGTAQLPPSQADILPPADPNITSLFVTGVEDDLPEHALRSFFVQFGQLRSLVCSHRAHCAFINYAARESAEAAAKHCQGKAVVQGCPLRVRWGKPKALDNMDREERLKYAREGRQAVGSLGNADQGTKAITAGTEKEQIPRQVAVAPPPGSGEVQYSSMSGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AX51</accession>
    <accession>C8VD98</accession>
    <name>Q5AX51_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CHAT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_07129</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF79016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_664733.1">
        <property type="nucleotide sequence ID" value="XM_659641.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AX51"/>
    <dbReference type="STRING" id="227321.Q5AX51"/>
    <dbReference type="GeneID" id="2869907"/>
    <dbReference type="KEGG" id="ani:ANIA_07129"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN7129"/>
    <dbReference type="eggNOG" id="KOG4626">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001305_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AX51"/>
    <dbReference type="OMA" id="THAHLAC"/>
    <dbReference type="OrthoDB" id="9991317at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024983">
        <property type="entry name" value="CHAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19959:SF119">
        <property type="entry name" value="FUNGAL LIPASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19959">
        <property type="entry name" value="KINESIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12770">
        <property type="entry name" value="CHAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHAT" evidence="1">
        <location>
            <begin position="681"/>
            <end position="995"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF79016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="997" mass="111698" checksum="898E7B31A42AE105" modified="2005-04-26" version="1">MADLEASIEHLREAVEQTAEGHPDRVEYLNDLGSQLEDRYSRTWALADLDEAIQVWREAVRAAPVNYPEHATYLDKLAGQLGVRYSKTGALADLEESIQLEREAVNKTPEDHPDHAMFLDNLGIQLRVRYSRTGTLKDLEESIQLGQKVVNTTSKDHPDRAMFLNNLGVRLRNKYLRTGSMTDLEASVQVWQEAVNTATEDDPDRALILSNLAGQLGVRYSRTGTLADLEESIQLGREAVNTTTEDHPDRAMFLNNLGIRLSDRYSRIGAMADLEEAIRVWREAVNAATEDDPDRTLLLGNLACQLKDRYTRTGALADLEESIQLGRDVVDTLPGGHPSRAMHLNNLEVRLSDRYSKFGAIADLEEAIQLGREAVQTTPESHPNYTMYLNNLGTLLGDRFARIGAMADIEESIKIGRQVIKAAPEDHPRKASWLKSLADQLRHRYSITGATADLYEAISYQETALHQENAFLSTRISAGKNALQNLAILSNWQQAYKSADTAVHLIPRLAMRSLENSDKQYLLGAMVGFASDAAAVALNAQKGAVVALDLLELGRGVLAASLDEIRVDTEDLQHKHPVMAERFVQLQAQARQNVEAERELDNLIMNIQSQPGFNNFLKAPSEEEILHAAQKGPIITINISQYRCDAIIVEHHRISSLPLPKLIIADITEKARWDDLGSPQVLEWLWDTTMEPILEVLGFIQSPSNREWPHVWWIPTGPLAKFPLHAAGYHSQGNSKTVLDRVMSSYSSSIKAIIRGRQRLATESLPFALLLSMQDTPGNGYLPFAAEEVQILCDMCKLMALHTIQPRRREHDIIGHMRVCQIFHFAGHGYTSHTDPSQSRLILWDGDDDSLTVGSLLKMNLHKNPPFLAYLSACGTGQIKDDKLIDESIHLTSAFQLAGFRHVIGTLWNVNDDICVDMARITYTEIANGNMDDESVCRGLHYAAREMRDRWLEALSEIEHPTATNRVRDIIPNDIDLAGNRSERRQALWVPYIHFGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AY84</accession>
    <accession>C8V1Y6</accession>
    <name>Q5AY84_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Aromatic ring-opening dioxygenase family protein (AFU_orthologue AFUA_7G00640)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ANIA_06746</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DODA-type extradiol aromatic ring-opening dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF71376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_664350.1">
        <property type="nucleotide sequence ID" value="XM_659258.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AY84"/>
    <dbReference type="STRING" id="227321.Q5AY84"/>
    <dbReference type="GeneID" id="2870263"/>
    <dbReference type="KEGG" id="ani:ANIA_06746"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN6746"/>
    <dbReference type="eggNOG" id="ENOG502S0K5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046582_4_0_1"/>
    <dbReference type="InParanoid" id="Q5AY84"/>
    <dbReference type="OMA" id="FDPHFHM"/>
    <dbReference type="OrthoDB" id="7396853at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07363">
        <property type="entry name" value="45_DOPA_Dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.830.10">
        <property type="entry name" value="LigB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014436">
        <property type="entry name" value="Extradiol_dOase_DODA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004183">
        <property type="entry name" value="Xdiol_dOase_suB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30096">
        <property type="entry name" value="4,5-DOPA DIOXYGENASE EXTRADIOL-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30096:SF1">
        <property type="entry name" value="AROMATIC RING-OPENING DIOXYGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_7G00640)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02900">
        <property type="entry name" value="LigB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006157">
        <property type="entry name" value="Doxgns_DODA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53213">
        <property type="entry name" value="LigB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Extradiol ring-cleavage dioxygenase class III enzyme subunit B" evidence="6">
        <location>
            <begin position="6"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBF71376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="299" mass="33249" checksum="A663B6688F011FB3" modified="2005-04-26" version="1">MGLTPVHFFSHGSTMMLGEESSSAEYWRKCGAEALARGIKGVVIMLQGAHWDTAGDAIEVSMNPNPGKSPVAYVHPSKYVDYNLTPDLSMGQRCISMLQSAGFSVSGNDKFDWIHDVYLILIHMFPGTSPPTTIISMNARYDPHYHVKIGSTLRPLRAENYLLIGTGGAVHNLYRNKWGPMLRFRDNFAMETPPEDWALEFRQAVEDVIVKVGGGPGLRRAMTRLMKHPRYRDAHATDDHFMAAMFVAGLVGEWEDVGTKTVLGAESWELTNMCNSQFTFGEWNGSNNGGGRKFVEVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AYM9</accession>
    <accession>C8V137</accession>
    <name>Q5AYM9_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">CLPTM1 domain protein (AFU_orthologue AFUA_6G04110)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ANIA_06601</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CLPTM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF71073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_664205.1">
        <property type="nucleotide sequence ID" value="XM_659113.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AYM9"/>
    <dbReference type="STRING" id="227321.Q5AYM9"/>
    <dbReference type="GeneID" id="2870519"/>
    <dbReference type="KEGG" id="ani:ANIA_06601"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN6601"/>
    <dbReference type="eggNOG" id="KOG2489">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019907_2_0_1"/>
    <dbReference type="InParanoid" id="Q5AYM9"/>
    <dbReference type="OMA" id="TLWAHFY"/>
    <dbReference type="OrthoDB" id="378564at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008429">
        <property type="entry name" value="CLPTM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21347">
        <property type="entry name" value="CLEFT LIP AND PALATE ASSOCIATED TRANSMEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21347:SF0">
        <property type="entry name" value="LIPID SCRAMBLASE CLPTM1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05602">
        <property type="entry name" value="CLPTM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="342"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="383"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="470"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="498"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="594"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="606"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="617"/>
            <end position="633"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBF71073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="633" mass="71663" checksum="85413ED30856F1CF" modified="2005-04-26" version="1">MPEQRQQREEGEQGSIVRSLIQGVTIFFVTQFFIGQFFGNKQNATAGGKPGAVTSFGERPPQAEVENYSSVPDTIAPIWPSDSALDISVYVSPSIVLPSISSLPSSSLVLEEKKFGLGNYSDVREVETTIQVPKEVQHNGTLWAHFFVALSGHELDPAAKGYSTDTAVHFLRPLNQYLPKRKAKKLKNLLAGADETDEEEDDGTPDVSIASYYHPNFTLSVIPDSGNMKYRQIHPAIRRHTQLEATGARDASGQNGWYYPIVFLNTFWQLRSHMVELNSTVETIPLRFTLQNLQNWKFAMMASLDENAKQTAKQAAFGGSTPGGGDGSEFEMIKEVLLDTNIWLLGTTGVVTILHMIFETLAFKNDISHWRKKKDNVGTSVRTILANVFMQTVIFLYLMDNSENTSWMILASQGFGIVLEAWKVTKTVNVRLRPPPVGSFFSFLPYVVVFEDKHKLTETEKKTQEYDEIAFRYLYIIAVPLLGAYAAYSLMYNTHKSWYSYIIETLVGSVYAYGFLMMVPSLYINYRLKSVAHMPGKAMTYKFLNTFIDDLFAFTVKMPWLHRLATLRDDVIFFIWLYQSYKYKVDYTRVNEFGQGGESDGEEEEDVKKLDEKENATRATGKQASQTSARKRK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-12-20" modified="2025-04-09" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AYR3</accession>
    <accession>C8V0V0</accession>
    <name>EPL1_EMENI</name>
    <protein>
        <recommendedName>
            <fullName>Enhancer of polycomb-like protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">epl1</name>
        <name type="ORF">AN6567</name>
    </gene>
    <organism>
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair. Involved in gene silencing by neighboring heterochromatin, blockage of the silencing spreading along the chromosome, and required for cell cycle progression through G2/M.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the enhancer of polycomb family.</text>
    </comment>
    <dbReference type="EMBL" id="AACD01000109">
        <property type="protein sequence ID" value="EAA57907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF71000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_664171.1">
        <property type="nucleotide sequence ID" value="XM_659079.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AYR3"/>
    <dbReference type="SMR" id="Q5AYR3"/>
    <dbReference type="STRING" id="227321.Q5AYR3"/>
    <dbReference type="EnsemblFungi" id="CBF71000">
        <property type="protein sequence ID" value="CBF71000"/>
        <property type="gene ID" value="ANIA_06567"/>
    </dbReference>
    <dbReference type="KEGG" id="ani:ANIA_06567"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN6567"/>
    <dbReference type="eggNOG" id="KOG2261">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010580_1_0_1"/>
    <dbReference type="InParanoid" id="Q5AYR3"/>
    <dbReference type="OMA" id="HIKWNEG"/>
    <dbReference type="OrthoDB" id="435275at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032777">
        <property type="term" value="C:piccolo histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024943">
        <property type="entry name" value="Enhancer_polycomb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019542">
        <property type="entry name" value="Enhancer_polycomb-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14898">
        <property type="entry name" value="ENHANCER OF POLYCOMB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10513">
        <property type="entry name" value="EPL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_0000214161" description="Enhancer of polycomb-like protein 1">
        <location>
            <begin position="1"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="541"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="543"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="570" mass="65060" checksum="4FE9DB35580852E7" modified="2005-04-26" version="1">MTRYAGLGRTRPKKLTPKAPIPIYREHQIDDLEEEIQNGLQQVETGVEKAEESEYHLQVAINAVASGRVVNEAHIPTPETVLSNLQYDELYPPVFSQPATYIRFSSTVEDCCGCPYNMTDEDDVFLKIMNEKRDPADRCTEDQFEEVMNFFEETVRLKQPYAAVGSAPVLSFAEMQESMDATVEDYVRRLAKDVYDHWKTRRLNNGNQSLLPSLKFETGAETDDTDPYVCFRRREVRQVRKTRGRDAQSADKLRRLRKELEDARQLVALVRQRELARKEMLATERILFLQRAEVKDMKRKLNIKDDDEDLINQKPKKKPIEAPPMQRPAAAQLRMPPKPGAQAAEDLQLLEDVQAEKENEIIRDIKANIAKHMKWNEGYVDFTRAPLSPSPERTVDISFRPAITTQLPTPPSSDSSENTPDLALDMSGTVSYRDKLDEHALIMSEDANKMPSFRRRIGRGGRLLIDRRNFASRCRVELDPWKADRFKYDQEDSDEDLDYEMDQYDISLMQNRAIMLAKARDQAHAQAQAAQVRRLQAEQAALNNLNSGQTSGQTMGSNPGPGAIAPTPET</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="121" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AYZ3</accession>
    <accession>C8V0B0</accession>
    <name>Q5AYZ3_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Probable aspartic-type endopeptidase OPSB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Probable aspartic-type endopeptidase opsB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">ANIA_06487</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="20">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF70833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_664091.1">
        <property type="nucleotide sequence ID" value="XM_658999.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AYZ3"/>
    <dbReference type="FunCoup" id="Q5AYZ3">
        <property type="interactions" value="334"/>
    </dbReference>
    <dbReference type="GeneID" id="2870229"/>
    <dbReference type="KEGG" id="ani:ANIA_06487"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN6487"/>
    <dbReference type="eggNOG" id="KOG1339">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013253_9_3_1"/>
    <dbReference type="InParanoid" id="Q5AYZ3"/>
    <dbReference type="OMA" id="CNVTLGT"/>
    <dbReference type="OrthoDB" id="771136at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05474">
        <property type="entry name" value="SAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000011">
        <property type="entry name" value="Aspartic protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000068">
        <property type="entry name" value="Aspartic-type endopeptidase (OpsB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033876">
        <property type="entry name" value="SAP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF65">
        <property type="entry name" value="ASPARTIC-TYPE ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 16" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="8 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 16" id="KW-0645">Protease</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="Peptidase A1" evidence="18">
        <location>
            <begin position="41"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="active site" evidence="15">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <feature type="active site" evidence="15">
        <location>
            <position position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00067536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00068059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CBF70833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="454" mass="47915" checksum="162B3FBFA9DC60A4" modified="2005-04-26" version="1">MLRVGFDASTNEIPDPVARDRRRRKRDQTVAQLIDNEETLYFCNLTVGTPGQSLRLILDTGSSDLWCNAANSTLCSSPKDPCRISGSFDPSSSSSYSYISSDFNITYADGTGAAGDYATDTVSIGGATIKDFQFGIGYTSSSAEGVLGIGYPSNEVQVARYGDDAYPNLPRFLMQNGFVQSSAYSLWLNDLEANTGSILFGGVDTEKYRGDLQTLPIQTVNGEYSELIIALTGVSLDTEARKHTVSSNALPAAVLLDSGSSLSYLPDSIAEKIYDDLRISYEPSTGAGYAPCSLARQNINVTFTFSSPEIAVGIDELIIDAGDLRFSNGERACIFGLVPAGDNTAVLGDTFLRSAYVVYDLTNNEISIAKTNFNSTKSNILEIGTGSDAVPGATKVSHPVTSVVADGSGSRIGAPTNTEDIVPSASTGAAVVLGRSTISPVLVGAAALGYMFAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AZX9</accession>
    <accession>C8V2A4</accession>
    <name>Q5AZX9_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Carboxyphosphonoenolpyruvate phosphonomutase-like protein (AFU_orthologue AFUA_5G07230)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ANIA_06151</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF70082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_663755.1">
        <property type="nucleotide sequence ID" value="XM_658663.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AZX9"/>
    <dbReference type="STRING" id="227321.Q5AZX9"/>
    <dbReference type="GeneID" id="2871122"/>
    <dbReference type="KEGG" id="ani:ANIA_06151"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN6151"/>
    <dbReference type="eggNOG" id="ENOG502RZTD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027389_2_0_1"/>
    <dbReference type="InParanoid" id="Q5AZX9"/>
    <dbReference type="OMA" id="GRAENFF"/>
    <dbReference type="OrthoDB" id="429143at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00377">
        <property type="entry name" value="ICL_PEPM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039556">
        <property type="entry name" value="ICL/PEPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42905:SF16">
        <property type="entry name" value="CARBOXYPHOSPHONOENOLPYRUVATE PHOSPHONOMUTASE-LIKE PROTEIN (AFU_ORTHOLOGUE AFUA_5G07230)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42905">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13714">
        <property type="entry name" value="PEP_mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF70082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="274" mass="29701" checksum="A0A54B6E01FEDFBB" modified="2005-04-26" version="1">MPIRTEHNNQAIYFRSLHDPKNPLILTNVYDAATASLIANHPSTKAIATGSYAIATSQGIPDDALSFPQNLAAIRSIASVLKRNEVLSHQDQTDISLRFPLTVDIQDGYNDVALTVKEIIKLGVVGCNIEDLDSNTGQLRPLLDAVHRIKVALQAAKESGVPDFVVNARTDVLGSLDKGTIEDAIERGKAYLDAGACTVFVWGGAGGRGVSKDEVERLVKAFEGRLNVKLVLREGFLTVRELKKLGLARISLGPELYRAAMNAFQEKADAVLRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="133" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B073</accession>
    <accession>C8V2U5</accession>
    <name>Q5B073_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450, putative (Eurofung)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ANIA_06057</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF70273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_663661.1">
        <property type="nucleotide sequence ID" value="XM_658569.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B073"/>
    <dbReference type="STRING" id="227321.Q5B073"/>
    <dbReference type="GeneID" id="2871147"/>
    <dbReference type="KEGG" id="ani:ANIA_06057"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN6057"/>
    <dbReference type="eggNOG" id="KOG0157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_27_0_1"/>
    <dbReference type="InParanoid" id="Q5B073"/>
    <dbReference type="OMA" id="VPEHYEH"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11063">
        <property type="entry name" value="CYP52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047146">
        <property type="entry name" value="Cyt_P450_E_CYP52_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287:SF1">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="462"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBF70273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="517" mass="58818" checksum="18A3B0CDAC302025" modified="2005-04-26" version="1">MLFLSVLLAFAAYLLIYQYAMTNWNHARRARLWGCSPLPRYPTDILGLATLRESLKADKEKKIPLLLQNRLKRMSAREKRPVTTFVIRQMGLDNIFTCDHGNVQAILATKFKNFELGVGRRHTLYPMFGVGIFTSDGETWSRSRALLRPQFTRDQISDLDLEESHVQQAMRAMNVDPATGWTSSIDIQAIMFRLTIDSATEFLFGESAGSQAEALRNGGTLPLNHFSGDFDLGQWYVAQRSRFEKFYWLVDNRESRAVVKRVHEYVDRFVHAVLTTAEDRIEKSQSSSYVFLEALAASTKDPIELRSQLLNILLAGRDTTASLLSWSILMLARYPEVFTKLRSVILADFGSYTSSRDKITFASLKSCRYLQYFLNEVLRLYPAVPINRRVATTATTLPKGGGPAGDKPIYLRAGQVVTYSPFVTHRRTDLWGEDAEVFNPERWVNKKVGWEYLPFNGGPRVCIGQQFALTEAGYVIVRLLQRFDAIMDCFPEREIRYGLTLTLAPADGVFVRLHAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="102" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B0F3</accession>
    <accession>C8V3B7</accession>
    <name>Q5B0F3_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ketoreductase (AFU_orthologue AFUA_2G10280)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ANIA_05977</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF70432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_663581.1">
        <property type="nucleotide sequence ID" value="XM_658489.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B0F3"/>
    <dbReference type="FunCoup" id="Q5B0F3">
        <property type="interactions" value="232"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5B0F3"/>
    <dbReference type="GeneID" id="2870881"/>
    <dbReference type="KEGG" id="ani:ANIA_05977"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN5977"/>
    <dbReference type="eggNOG" id="KOG1502">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_9_2_1"/>
    <dbReference type="InParanoid" id="Q5B0F3"/>
    <dbReference type="OMA" id="QGQMKEK"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd05227">
        <property type="entry name" value="AR_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000191">
        <property type="entry name" value="Methylglyoxal reductase (NADPH-dependent)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF564">
        <property type="entry name" value="STEROL-4-ALPHA-CARBOXYLATE 3-DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="4"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBF70432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="334" mass="36835" checksum="DA99451D47A8409C" modified="2005-04-26" version="1">MPKVLLTGGSGFIAAHILDQLLERGFDVVTTVRSKEKGEKILAAHPNTPKEKLSYVIVKDVAQDGAFDEAVKSDPPFDYVLHTASPFHYNVQDPVRDFLDPAIKGTTGILKAIKAYAPNVKRVTITSSFAAIVNVKNHAKVYSEEVWNPITWEEGLDSSQTYRASKTLAEKAAWDFVEKEKPSFDLATINPPLVLGPVVHYLSSLDSINTSNARISSFVRGFSKDALPPTGTYVWVDVRDVALAHVRTIEVPEAGGQRFFITAGHYSNKDIVDIIRDAYPELEDRLPPKDAPSDMPKDVYGYDNSKSMQVLGLKYRGLKESVVDTVKSLLENGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B0J0</accession>
    <accession>C8V3I0</accession>
    <name>Q5B0J0_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DUF636 domain protein (AFU_orthologue AFUA_1G03180)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ANIA_05940</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF70524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_663544.1">
        <property type="nucleotide sequence ID" value="XM_658452.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B0J0"/>
    <dbReference type="STRING" id="227321.Q5B0J0"/>
    <dbReference type="GeneID" id="2870829"/>
    <dbReference type="KEGG" id="ani:ANIA_05940"/>
    <dbReference type="eggNOG" id="ENOG502S5AR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055491_3_6_1"/>
    <dbReference type="InParanoid" id="Q5B0J0"/>
    <dbReference type="OMA" id="QIWCRSA"/>
    <dbReference type="OrthoDB" id="406544at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="Gene3D" id="3.90.1590.10">
        <property type="entry name" value="glutathione-dependent formaldehyde- activating enzyme (gfa)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337:SF30">
        <property type="entry name" value="DUF636 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G03180)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337">
        <property type="entry name" value="GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="5">
        <location>
            <begin position="2"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBF70524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="142" mass="15473" checksum="0AE36609FD8AA1D5" modified="2005-04-26" version="1">MPVGSCFCGKIQLEFTNSPITSGLCYCSDCRKNSGSLFTYSFVFRNADVKITGSPKVVTKRADSGNTVKNHFCDECGTPLYGLRVNPDGSQGESMIVRAGIFDNLSLFNQVKPKAELYVDGRVSWLCPIEGAEQFVGMVPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="130" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B0L7</accession>
    <accession>C8UZT8</accession>
    <name>Q5B0L7_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Zinc-binding dehydrogenase family oxidoreductase, putative (JCVI)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ANIA_05913</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF70583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_663517.1">
        <property type="nucleotide sequence ID" value="XM_658425.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B0L7"/>
    <dbReference type="STRING" id="227321.Q5B0L7"/>
    <dbReference type="GeneID" id="2870907"/>
    <dbReference type="KEGG" id="ani:ANIA_05913"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN5913"/>
    <dbReference type="eggNOG" id="KOG0023">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_20_1_1"/>
    <dbReference type="InParanoid" id="Q5B0L7"/>
    <dbReference type="OMA" id="CEICAVN"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08297">
        <property type="entry name" value="CAD3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Alcohol dehydrogenase AdhP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940:SF2">
        <property type="entry name" value="DEHYDROGENASE FAMILY OXIDOREDUCTASE, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="10">
        <location>
            <begin position="16"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CBF70583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="351" mass="37503" checksum="8AAEF8ED8C685DAC" modified="2005-04-26" version="1">MATPQLQTAAVLPSTGATLTSRLEIRHDRPIPSPAAGELLVKLEFSGVCHSDVHSVRGETPMLTDVAGHEGVGKVVKVGDGVDEGAWMGRRVGIRWLYSSCLECEICERNNTACPNQKNAGANVPGTFQQYIVSPAMHVTKIPPQLSPDEAAPLLCAGIAMYSSIMKTKTRPGDWIVFPGAGGGLGHMGVQIAVKKGLRVIAIDSGEKKQKLCLSLGATAFLDYKTDDVESAVKQLTSGLGAHAVICTANGEAAYEQSMRLLRRLGVLVCVGIPNLPFRLPATPFDMIVKGLTIVGNSAGTAEEMEELMEMAVAGDLKAHIECFEFDQIDDVIQRLGRSEIEGRAVMRIPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B1I5</accession>
    <accession>C8VG10</accession>
    <name>Q5B1I5_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Involucrin repeat protein (AFU_orthologue AFUA_4G11410)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ANIA_05595</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF81596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_663199.1">
        <property type="nucleotide sequence ID" value="XM_658107.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B1I5"/>
    <dbReference type="SMR" id="Q5B1I5"/>
    <dbReference type="STRING" id="227321.Q5B1I5"/>
    <dbReference type="GeneID" id="2871883"/>
    <dbReference type="KEGG" id="ani:ANIA_05595"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN5595"/>
    <dbReference type="eggNOG" id="ENOG502QWKV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006409_0_0_1"/>
    <dbReference type="InParanoid" id="Q5B1I5"/>
    <dbReference type="OMA" id="IDDYEVM"/>
    <dbReference type="OrthoDB" id="5569911at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056703">
        <property type="entry name" value="DUF7801"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029191">
        <property type="entry name" value="Uds1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45615">
        <property type="entry name" value="MYOSIN HEAVY CHAIN, NON-MUSCLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45615:SF40">
        <property type="entry name" value="MYOSIN HEAVY CHAIN, NON-MUSCLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25078">
        <property type="entry name" value="DUF7801"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15456">
        <property type="entry name" value="Uds1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Up-regulated during septation protein 1" evidence="3">
        <location>
            <begin position="76"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7801" evidence="4">
        <location>
            <begin position="714"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="202"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="469"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="706"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="774"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="904"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF15456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBF81596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="941" mass="106856" checksum="12CAD8E8BA567F4F" modified="2005-04-26" version="1">MNGFDFRSSQSSYGDPRHFSDASYGVPQPPPTKVLLDGYRDALGPANAEKSLYNSANPTSHPRRSIPPSANDPVAMYLLTETAMGDSVNYEILSVEEVEGLKKELRVLSNRMNAAKRKLALELKLRDAAMSLSRLHHKEEHDVDGSGRNEPNTDKTNEELVHINRKCEELSMDIWYSERKVQEIQKRLLEHTAGVLQLTHKGLKKNSKNGMPHTPESLSSSNTVDDFDDRSLYKASDPLDGPETYETRAPPPDNLAHDNSMQETERKLESMSSRLRDMLLQLDPDSEFSQIPQPSTSGDSFEPSAMIDAHLRYIENGISALGSLPKADMASQSLDPVSEQQLVEMRTQLLSIMENPGLPRAQTLPTAPDPTDSDLAKHLTFLSVGINGLESRVEKLLEQKSILTTQIQQQRELNSKSDAERDAKIADLIEQLAHLRKELELAEREGQQSKEDHDLTLKELEDVRRELLESRETHSSRDLGNSKNEAQQHAEAEIARLQSVIQEIQQEKDEHCEAHRRAEAEIDRLQAVIHQIQQEKDEHREAHERAEAETTRLQTIVEEVQQEKDEQHEAHGRAVAEVTRLQDIIQKIEQEKIERHEADERAEAEIVRLRDTIREIQQEKEEHHEARVRLEGEVARLQGVIGQLQESAESRESAEQQVAQLEETIHQIRHDADIRIKEATDSRAQADAKIAQLEGAMNEVRESLESQLKEATEARNNAEENSTRLQKELTELERDVVRAQTELTMVKAELDGAYGTRAQRAAEAAADPALFHELDELKARNFEMAEELAALKAGKPGSGDVHNRVETLERELRETVDDYEAMTKASIEFEKERERFESMIDSLRDRCEQLETQLNEERISWMGANNSASSMGRDGPYETTSTMVLKNEFKKMMRDTRAENMKILKAEQEERRKLEAILRNLKREQANLSGKSNISRTVTAS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-12-20" modified="2025-06-18" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B1Z0</accession>
    <accession>C8VGI0</accession>
    <name>CCPR2_EMENI</name>
    <protein>
        <recommendedName>
            <fullName>Putative heme-binding peroxidase</fullName>
            <ecNumber>1.11.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="ORF">AN5440</name>
    </gene>
    <organism>
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
        <text evidence="2">Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peroxidase family. Cytochrome c peroxidase subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.-"/>
    <dbReference type="EMBL" id="AACD01000094">
        <property type="protein sequence ID" value="EAA62600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF81905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_663044.1">
        <property type="nucleotide sequence ID" value="XM_657952.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B1Z0"/>
    <dbReference type="SMR" id="Q5B1Z0"/>
    <dbReference type="FunCoup" id="Q5B1Z0">
        <property type="interactions" value="75"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5B1Z0"/>
    <dbReference type="PeroxiBase" id="3835">
        <property type="entry name" value="AniCcP01"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CBF81905">
        <property type="protein sequence ID" value="CBF81905"/>
        <property type="gene ID" value="ANIA_05440"/>
    </dbReference>
    <dbReference type="KEGG" id="ani:ANIA_05440"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN5440"/>
    <dbReference type="eggNOG" id="ENOG502QR1E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036959_0_1_1"/>
    <dbReference type="InParanoid" id="Q5B1Z0"/>
    <dbReference type="OMA" id="GAWVNNP"/>
    <dbReference type="OrthoDB" id="2859658at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000302">
        <property type="term" value="P:response to reactive oxygen species"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00691">
        <property type="entry name" value="ascorbate_peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.420.10:FF:000009">
        <property type="entry name" value="Ascorbate peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.520.10:FF:000005">
        <property type="entry name" value="Cytochrome c peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.420.10">
        <property type="entry name" value="Peroxidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044831">
        <property type="entry name" value="Ccp1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002016">
        <property type="entry name" value="Haem_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002207">
        <property type="entry name" value="Peroxidase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019794">
        <property type="entry name" value="Peroxidases_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31356:SF36">
        <property type="entry name" value="L-ASCORBATE PEROXIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31356">
        <property type="entry name" value="THYLAKOID LUMENAL 29 KDA PROTEIN, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00141">
        <property type="entry name" value="peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00459">
        <property type="entry name" value="ASPEROXIDASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00458">
        <property type="entry name" value="PEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00436">
        <property type="entry name" value="PEROXIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50873">
        <property type="entry name" value="PEROXIDASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0349">Heme</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-0575">Peroxidase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000055587" description="Putative heme-binding peroxidase">
        <location>
            <begin position="1"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="276"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2 3">
        <location>
            <position position="38"/>
        </location>
    </feature>
    <feature type="active site" description="Tryptophan radical intermediate" evidence="1">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="2">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="2">
        <location>
            <position position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <sequence length="312" mass="34521" checksum="FEF3CFBF0E54C880" modified="2005-04-26" version="1">MSKPGDYNAVRRDIAAQLKKPGYDDGSAGPVFVRLAWHSSGTYDAASDTGGSNGAGMRYEAEGGDPANAGLQHGRAFLEPVKEKHPWITYSDLWTLAGVVAIEEMGGPKIPWLPGRTDFVDDSKVPPRGRLPDGAQGADHLRFIFYRMGFNDQEIVALAGGHNLGRCHADRSGFQGPWVNNPTRFSNQFFKLLLNMEWKPKTLENGVSQFVYIDPEAEDHEEPLMMLPTDVALRDDPAFRPWVERYAKDKDLFFDHFSKAFAKLIELGIQRDASGKVTNTDNVKGGYHSAPKKSDEPTGPPRPHTAQRAAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B2T9</accession>
    <accession>C8VF05</accession>
    <name>Q5B2T9_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">YAG7-like dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ANIA_05141</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF80940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_662745.1">
        <property type="nucleotide sequence ID" value="XM_657653.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B2T9"/>
    <dbReference type="STRING" id="227321.Q5B2T9"/>
    <dbReference type="GeneID" id="2871425"/>
    <dbReference type="KEGG" id="ani:ANIA_05141"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN5141"/>
    <dbReference type="eggNOG" id="ENOG502S59W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031644_0_0_1"/>
    <dbReference type="InParanoid" id="Q5B2T9"/>
    <dbReference type="OMA" id="EEAWVDD"/>
    <dbReference type="OrthoDB" id="5399559at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058602">
        <property type="entry name" value="YAG7_dimerisation_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26434">
        <property type="entry name" value="YAG7_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YAG7-like dimerisation" evidence="3">
        <location>
            <begin position="156"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="238"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="283"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="70"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="10"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="388"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="404"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF26434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBF80940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="429" mass="45650" checksum="394AC7A1504C7691" modified="2005-04-26" version="1">MAAAAVDTAPAQSPSPSDVKPNSVTNSVPSELVEFPHYRELQRNLRNNVKKLNATSKVDAVIANNPDKTLDELVAEKKINEDQKAQALKKPVLQATIAQLEEQIAHYKEFATFYEQRLASQKAELEKAHKEVEALREKAATATPAPAEQTPEVKKEDAAQQLLSVSRFLSTAAIRRHRGEDETTAESRAFEGVLAQVYGGHLDAVASMQKLIDGADEKVVSVDGEKLEVTFARVKQLSEQETVASAASQPAPEAATDPTTANAASTELQDPVYVTEAAIDNAATASTNEAESVAPPPQTLVGEGANAVAESAWEPNSDPLASSTNTEGFVEIPRDPAETETGLQATPANITADVASEDAEKTENDFEQVGSRHQRQSSFRGRGRGRGRGGDNFRGRGRGDFRGRGRGRGRGGRGRGGPNGAPAATPAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="119" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B3T0</accession>
    <accession>C8VAL7</accession>
    <name>Q5B3T0_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WD repeat protein (AFU_orthologue AFUA_3G06910)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ANIA_04800</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF76755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="XP_662404.1">
        <property type="nucleotide sequence ID" value="XM_657312.1"/>
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    <dbReference type="AlphaFoldDB" id="Q5B3T0"/>
    <dbReference type="STRING" id="227321.Q5B3T0"/>
    <dbReference type="GeneID" id="2872599"/>
    <dbReference type="KEGG" id="ani:ANIA_04800"/>
    <dbReference type="eggNOG" id="KOG0266">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014280_1_0_1"/>
    <dbReference type="InParanoid" id="Q5B3T0"/>
    <dbReference type="OMA" id="FGQWTIT"/>
    <dbReference type="OrthoDB" id="63070at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080008">
        <property type="term" value="C:Cul4-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="entry name" value="WD repeat protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051859">
        <property type="entry name" value="DCAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19847">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19847:SF7">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="338"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="373"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="420"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="517"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="32"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="56"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBF76755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="660" mass="73923" checksum="9F40C23349A9DEDD" modified="2005-04-26" version="1">MSSPPIAGGDRRDGSPSVGPGGTWHPARAWLEEDETGDDEDDMDYEPDSDNHDDRADEEEYPDEDPNVDQSDSELHLGNIHIEFTMDEHDQTGEVSPARLLNILASGGLQQIFRYHGFATGNAGFDGDDDGEEDEYGILGLGRRVPRRRGPPQYPKIPSDEGIKLMRSGKFGTEPSYVDERMKRKKSLAEKVMWRELGVDGQGLQRTRVSSIAQGLIPGTTADKIIHYDAKCYSGQFSDDGNFFFSCAQDFKVRMYDTSNPYEWKYYKTVDYPLASWTITDATLSPDNRFLAYSSLRQLVCLAPTDPADSSDPIILDLASSAQRRVARDIFGRDGFAVWSVRFSGDGREIVAGTGDHSVIVYDLETRQSVLRIRNHEDDVNAVCFGDKSSPHILYSGSDDSTVRVWDRRSMADGREAGVFVGHTEGLTYVDSKGDGRYVLSNSKDQTMKLWDLRKMMSTAKFDTLEPTSYGTGFDYRFDPFPSDFYYPHPHDCSVVTFRGHSVLRTLIRCHFSPPGSSDSRYVYSGSEDGKVYVWNLDATLAGTVDVQKATHFSRPRSRRFQGHMYMSRADGNQWKTCVRDASWHPNAPVLAATSWNGWGSSTGTCTIHSWNNGADQDECGPKFSYGDSYDAQLNATNLSEKALDMRAWEYEHALNEASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B429</accession>
    <accession>C8VAX5</accession>
    <name>Q5B429_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SRR1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_04701</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF76967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_662305.1">
        <property type="nucleotide sequence ID" value="XM_657213.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B429"/>
    <dbReference type="GeneID" id="2872496"/>
    <dbReference type="KEGG" id="ani:ANIA_04701"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN4701"/>
    <dbReference type="eggNOG" id="ENOG502SC31">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048152_2_0_1"/>
    <dbReference type="InParanoid" id="Q5B429"/>
    <dbReference type="OMA" id="EHAFWNM"/>
    <dbReference type="OrthoDB" id="5318346at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012942">
        <property type="entry name" value="SRR1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42080">
        <property type="entry name" value="SRR1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42080:SF1">
        <property type="entry name" value="SRR1-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07985">
        <property type="entry name" value="SRR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRR1-like" evidence="2">
        <location>
            <begin position="140"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="41"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF76967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="322" mass="35781" checksum="86CC5FF3C907CE5D" modified="2005-04-26" version="1">MPHTRRKKPSPSQNKRLQVTDDSGWTHVTTNKHARRIRQPSVNPNSGSSSTGNRNGLEKDAAKEEIAEELVPAEAPQKTTLSDLQRQLGLYKQRWEESVTWDCVVEGLRRGVPSLLAERGSSSNSDGDGEKEVKDKDENQSKNGISIICIGLGSPSGFLRGGWVDRRAVSMYQLAALASILEWIGESTSMQNPNPGMRAYAQDPVFNTHDETLLNELKITVLTHPGAFQKVTPKTLLFCPGAERRHIELLLAHDPAIVVGGPLEDIESDVVRRFVERRESVRLKEFAELETAFWGMRIYFPRSGAEKQDKVSSRIQEGGAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B4W5</accession>
    <accession>C8V8S6</accession>
    <name>Q5B4W5_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Holocytochrome c-type synthase</fullName>
            <ecNumber evidence="10">4.4.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">ANIA_04415</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>holo-[cytochrome c] = apo-[cytochrome c] + heme b</text>
            <dbReference type="Rhea" id="RHEA:22648"/>
            <dbReference type="Rhea" id="RHEA-COMP:10725"/>
            <dbReference type="Rhea" id="RHEA-COMP:10726"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="ChEBI" id="CHEBI:83739"/>
            <dbReference type="EC" id="4.4.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the cytochrome c-type heme lyase family.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.17" evidence="10"/>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF77573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_662019.1">
        <property type="nucleotide sequence ID" value="XM_656927.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B4W5"/>
    <dbReference type="FunCoup" id="Q5B4W5">
        <property type="interactions" value="46"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5B4W5"/>
    <dbReference type="GeneID" id="2872208"/>
    <dbReference type="KEGG" id="ani:ANIA_04415"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN4415"/>
    <dbReference type="eggNOG" id="KOG3996">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048602_1_0_1"/>
    <dbReference type="InParanoid" id="Q5B4W5"/>
    <dbReference type="OMA" id="SCPVDHK"/>
    <dbReference type="OrthoDB" id="4243at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004408">
        <property type="term" value="F:holocytochrome-c synthase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000511">
        <property type="entry name" value="Holocyt_c/c1_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12743">
        <property type="entry name" value="CYTOCHROME C1 HEME LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12743:SF0">
        <property type="entry name" value="HOLOCYTOCHROME C-TYPE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01265">
        <property type="entry name" value="Cyto_heme_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00821">
        <property type="entry name" value="CYTO_HEME_LYASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00822">
        <property type="entry name" value="CYTO_HEME_LYASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0349">Heme</keyword>
    <keyword evidence="6 10" id="KW-0408">Iron</keyword>
    <keyword evidence="9 10 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="73"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CBF77573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="288" mass="31195" checksum="F53BF1764FF87A50" modified="2005-04-26" version="1">MGAGASTPVSPPPSTPAATCPVDHKTREAWLQQHKPGEAPHPVASNDGVPTTMKQHRPLSTDREVSSIPRAVASDSDAPPSECPAAPSSPYASPTASHGTPSNAETETGHDKSTGNWIYPSERQFFEALMRKGNTPNSVSSASELATTVASIIPIHNAVNERAWQQILEWEQKAPLSDPGSKKCGGPKLYSFRGLGSEPEFLSPRARMNSLMGYQLPFDRHDWVVERCDGQRIEYVIDFYQGKSTGGSSRGGLAANAGPGKLSFYLDVRPKLNSWEGCMMRFRRFSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B5F2</accession>
    <accession>C8V4A2</accession>
    <name>Q5B5F2_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Zinc metallopeptidase, putative (AFU_orthologue AFUA_1G06270)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ANIA_04228</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF74438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_656740.1"/>
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    <dbReference type="KEGG" id="ani:ANIA_04228"/>
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    <dbReference type="GO" id="GO:0016814">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines"/>
        <property type="evidence" value="ECO:0000318"/>
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        <property type="entry name" value="Bact_CD"/>
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        <property type="entry name" value="Metal-dependent hydrolases"/>
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        <property type="entry name" value="Metal_Hydrolase"/>
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        <property type="entry name" value="Metallo-hydrolase_Enzymes"/>
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        <property type="entry name" value="CYTOSINE DEAMINASE"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR32027:SF0">
        <property type="entry name" value="CYTOSINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF74438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="495" mass="53884" checksum="1AEFD7EADAAA32F1" modified="2005-04-26" version="1">MPPRLGYPVKTIHSVKLAATNPETTWDIAIGYLPDSPEGVISSITPDYSSTSSRPLSPLALPALVHPHIHLDKAYVHSTSSYTDLFPSTGSFQEALTLTSTAKASFTGPDLLQRGEWLLAESVASGVTAMRAFVEVDHAVQHACLDAGLDLKRKWQEACEIQLVCFAQDPVISTAHADENRGLIEDAIQKYGPEKLAVLGTTPYVESSIEASKRNIEWAVDTAMRHDRHLDFHLDYNLAHLEDMPEPLVWHVLRTLRAKGWTARTTDKRVMLGHCTRLSLFTEEDWGRLAQEIHENDLPVSFVGLPTSDLYMAAAPSNVYKANPRGTLPIPSMIKNHGLDAVIGINNVGNAFTPWGSADPLSLACLGVGIYQAGTVSDAELLYECVSTRARDAIGLSSSSLSRINSSPRSTFDVRLKCGDPADLLLLYDVDDTGLLESGTTRARKTVAEVVWDPPARTSRAVVMKGRVKMPALSAGCGTAFQFVEQDPRLVESSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B608</accession>
    <accession>C8V5P4</accession>
    <name>Q5B608_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_04022</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF74868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_661626.1">
        <property type="nucleotide sequence ID" value="XM_656534.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B608"/>
    <dbReference type="STRING" id="227321.Q5B608"/>
    <dbReference type="GeneID" id="2873439"/>
    <dbReference type="KEGG" id="ani:ANIA_04022"/>
    <dbReference type="eggNOG" id="ENOG502S2DX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019094_0_0_1"/>
    <dbReference type="InParanoid" id="Q5B608"/>
    <dbReference type="OMA" id="KAMLDHW"/>
    <dbReference type="OrthoDB" id="4115400at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="389"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="41"/>
        </location>
    </feature>
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            <begin position="389"/>
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        </location>
    </feature>
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            <begin position="426"/>
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        </location>
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        <location>
            <begin position="480"/>
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        </location>
    </feature>
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            <begin position="501"/>
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        <location>
            <begin position="591"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="636"/>
            <end position="657"/>
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    </feature>
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            <begin position="658"/>
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    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="694"/>
            <end position="709"/>
        </location>
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    <feature type="compositionally biased region" description="Pro residues" evidence="1">
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    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="737"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF74868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="750" mass="82154" checksum="2805BA3727DEBC7F" modified="2005-04-26" version="1">MESHTSEMASQDSPLRRKFSEPLHTKSDSTKTTPSPAPDASICAKCGEHIESSADMSLDAAIKRHMDYKHLTAKDMAPYKNHENGIDYESQTYDGDEDDEQVENGDLVVDQANGSPRSADYNDGNVEVAEEELAEATETYIGKKRATLDSDRAGVNGDGEVPEGESDVALSNQLHEFSRDEYSASIEKRLHNLWNIHDVREFTKDYEENTSEMNETWATVFHEAKSAKKRNAPEFLQRPDPYKATKVGRGEFLEMAPLEDFLSQLRDPELRTSDELYAITENVAYALKVWQDEFLAIDKLQKLATRHNLKVTSDPRKLERPQVFEDKKEAMLYGYKYDPKEDKVGHQNPFLQGGFKPTPAQYRKMLQKAGPNNPNPDGWRIISKFGVDHVPKFQNPPREDGIAKATRKRKAAELEAASRANESDEAAVAETATPAEPDQDSAKRRSRNRRQGDEPNAENGRSSTPRGRGGRPRGRGAARGGSRAASEAPLAPAPAAGNPAGSTPVSEGLTQARTGVSQLVPIEPAPNGGPATAPDAKPPAGGAQGVLDAAEEARRQKIANSKNPKRTEAMLNHWARFNREGRVRNPKRSKAQIEADRAADAARKASEGAKLGIKQKKKSASPALPNPPRVDAGLAPAPPQPMQLAPPPQLAPGPLPHPHSHPPPHPHPHSHTHTHTSQLPSQLPPLAAPRGLAPYPPPHLDPRPMPPFPLARGPGPLHQPPPQPYRTPYPDYFNSPYGPPPLPPPGHPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B7F7</accession>
    <accession>C8V4U0</accession>
    <name>Q5B7F7_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_03523</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF75976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_661127.1">
        <property type="nucleotide sequence ID" value="XM_656035.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B7F7"/>
    <dbReference type="GeneID" id="2872946"/>
    <dbReference type="KEGG" id="ani:ANIA_03523"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN3523"/>
    <dbReference type="eggNOG" id="ENOG502RW27">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051050_0_1_1"/>
    <dbReference type="InParanoid" id="Q5B7F7"/>
    <dbReference type="OMA" id="VRIYWAG"/>
    <dbReference type="OrthoDB" id="332863at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050114">
        <property type="entry name" value="UPF0173_UPF0282_UlaG_hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43546:SF7">
        <property type="entry name" value="METALLO-BETA-LACTAMASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43546">
        <property type="entry name" value="UPF0173 METAL-DEPENDENT HYDROLASE MJ1163-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="2">
        <location>
            <begin position="63"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF75976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="340" mass="37862" checksum="173D6806B07C8651" modified="2005-04-26" version="1">MQHIVIDPNHLQPPTRDTGTDQVPRTLPPVKNSKVHPSKPGSENASIYFIGNATTILEWQGVRILTDPNFLHAGDHLHLGPGLTSTRRHNPAVELQELPRIDLVLLSHYHEDHFDRKVEESLRRNLPIVTTSHAKSVLTSRGPDSFTNVYDLDPFHQMMINFATKIEAKDQYMPSLRVTGMPGKHAPLGTAMESLNDIVGAIPPTNGWILELGYGHSADGFKVGYRVYISGDTLMFDELNEIPKLYGEHNIDLMIIHLGAAMVPSPSLAPFTLMVTMNAKQGVELMQLVKPDITIPVHFDDYDIMSESLEDFKAAVANAGLGCGVVYLDRGEEYRFSVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B7Z7</accession>
    <accession>C8VHV9</accession>
    <name>Q5B7Z7_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Gfo/Idh/MocA-like oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_03333</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF82925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_660937.1">
        <property type="nucleotide sequence ID" value="XM_655845.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B7Z7"/>
    <dbReference type="SMR" id="Q5B7Z7"/>
    <dbReference type="STRING" id="227321.Q5B7Z7"/>
    <dbReference type="GeneID" id="2874223"/>
    <dbReference type="KEGG" id="ani:ANIA_03333"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN3333"/>
    <dbReference type="eggNOG" id="ENOG502SIG7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_377198_0_0_1"/>
    <dbReference type="InParanoid" id="Q5B7Z7"/>
    <dbReference type="OMA" id="QATHGAN"/>
    <dbReference type="OrthoDB" id="446809at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052515">
        <property type="entry name" value="Gfo/Idh/MocA_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43249:SF1">
        <property type="entry name" value="D-GLUCOSIDE 3-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43249">
        <property type="entry name" value="UDP-N-ACETYL-2-AMINO-2-DEOXY-D-GLUCURONATE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="1">
        <location>
            <begin position="446"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF82925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="790" mass="88906" checksum="19EC144B5A414FD2" modified="2005-04-26" version="1">MTINAYLSTYRSNERTEHQGGPFKISITAFRSTWSIGVTLRQLVGFTRPSAANHTMSYALVQYCLSRLPIQHLEQLGNLKIPFEIHAAPFQFLQKHHSAFGFDWVERLVWRTHDLHKPYNYLRPELLLAQEIDSQRLVAILTIMPGEDYIRHYASMVEVAQHDGAIFSNHGPIHCVLYPHLTQSMMTWTGLTELSANIEPGDVVVLGFVAELLSRFASLVPTSRMIWRQDSQYYGLVRLELHPGLVFSLVGAKYSYWGNLGGRVVTELAARRPRAICYIAKQGTLLSPDDIHCRIYSPTRYCVFDKGKACWHGDDHPALPINPLSSRSPTFDRGLHVSTPTIVEQDVELRTQLGAHGAASIDNELAQMARALTDMHEENPSMSRIQLLPIMFCTDYLRRPEELGMSVPFDLTSRNQTVQRGKELFLARAAHLVLEAFDVIQRPKAIIVGTGYGVKTILPALQRRGVEIVGLCGGHNRAKTETVATKHKIPCIDLSLKELQACHGANLLFVASPHDKHAALVQEALDLGGFDIICEKPLALDMTTMRHLVDQSLRSSQLCLINHALRFYPPLIHLKVASKEPANILTIDIRYLTRRLAKLTHWNSCFSKSAGGGMMLAMATHFLDLIEWFTDYPLTHDSMETITTSNSIAPLPTEDAQITKTPNVESAFEISGYCRSSTKYSVECDGAADTELFSVTIHLANENELRFIQQKGRPVMLEQRHSGREWLPLKVHLEQRVRDGSPWQVSFQYFVEELVEAICMGKRSAFADKSTGFDDYSRQVGVFGSRVGIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B835</accession>
    <accession>C8VI06</accession>
    <name>Q5B835_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_03295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF83011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_660899.1">
        <property type="nucleotide sequence ID" value="XM_655807.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B835"/>
    <dbReference type="STRING" id="227321.Q5B835"/>
    <dbReference type="GeneID" id="2873761"/>
    <dbReference type="KEGG" id="ani:ANIA_03295"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN3295"/>
    <dbReference type="eggNOG" id="ENOG502S8K0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053354_1_0_1"/>
    <dbReference type="InParanoid" id="Q5B835"/>
    <dbReference type="OMA" id="HPHLSIM"/>
    <dbReference type="OrthoDB" id="3202396at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025444">
        <property type="entry name" value="Monooxy_af470"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13826">
        <property type="entry name" value="Monooxy_af470-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF83011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="315" mass="34889" checksum="9C2BDCFC1FAAFDFF" modified="2005-04-26" version="1">MAPFKPLLPPLPIPEGQRKNPPLPIRPPSPTVILRDGLSLSTWLLLGGVLQGAAVAAFGYRSLLPTTLILGYRALDTLLMTLNLKRNRYMDGVIMPKYSAQYPNTDGSFASTLNPTTGSQDGDPAAKPLIVFHLGARCNHPLGLLAPGYKELGDWAEKMYESLRVNPDKYGLLGMTRFVGQSDAAGNETLVIMYMRDYEGLHRFAHDQLHADGVRWWTGIVKAHPHLAIWHETYVVPKGCWENIYAQSQVTGMGDTFFPVIDENNGATEWARGIVDAKGGALRTGSRRLRMKHLEENESELEAYYDLTDGGRTTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B9C9</accession>
    <accession>C8VJD3</accession>
    <name>Q5B9C9_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Oxidoreductase, 2OG-Fe(II) oxygenase family family (AFU_orthologue AFUA_3G11980)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ANIA_02851</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF83874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_660455.1">
        <property type="nucleotide sequence ID" value="XM_655363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B9C9"/>
    <dbReference type="STRING" id="227321.Q5B9C9"/>
    <dbReference type="GeneID" id="2873842"/>
    <dbReference type="KEGG" id="ani:ANIA_02851"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN2851"/>
    <dbReference type="eggNOG" id="KOG1591">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058132_0_4_1"/>
    <dbReference type="InParanoid" id="Q5B9C9"/>
    <dbReference type="OMA" id="TVQCIEQ"/>
    <dbReference type="OrthoDB" id="420380at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004656">
        <property type="term" value="F:procollagen-proline 4-dioxygenase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.620:FF:000027">
        <property type="entry name" value="Oxidoreductase, 2OG-Fe(II) oxygenase family family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045054">
        <property type="entry name" value="P4HA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869:SF246">
        <property type="entry name" value="TRANSMEMBRANE PROLYL 4-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="Prolyl 4-hydroxylase alpha subunit" evidence="7">
        <location>
            <begin position="86"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBF83874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="300" mass="34160" checksum="C2572AAA3C92231C" modified="2005-04-26" version="1">MPLNISLSSVFYLIPLYILVISPILRQLFPNDPQHGSYQFYDDEEALDEDTSLDLNSEVLSLDDGVNVVCPDETDAYRVHILSQAPLVIYIENFLSAEEADYLVDVSIPNYTPSTLYSSSLTSANDTSTPKTDVTKRLSDRALLPRTQTVRCIEARARSFQGWKPNLYIERMWAQRYNVSGHYTHHYDWAGTARGRGGDRISTFMVYLKAECKGGGTNFPLLRKPKDSKWCEFIECGEADEGRKGVTFKPIKGNAVFWENLRADGSGWPETWHAAFPVEEGEKVGLNIWSWYQPPKGRWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B9I9</accession>
    <accession>C8VJK6</accession>
    <name>Q5B9I9_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ANIA_02791</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF84004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_660395.1">
        <property type="nucleotide sequence ID" value="XM_655303.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B9I9"/>
    <dbReference type="GeneID" id="2873941"/>
    <dbReference type="KEGG" id="ani:ANIA_02791"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN2791"/>
    <dbReference type="HOGENOM" id="CLU_2158345_0_0_1"/>
    <dbReference type="InParanoid" id="Q5B9I9"/>
    <dbReference type="OrthoDB" id="27483at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF84004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="111" mass="12809" checksum="F8B0BA1FA5B8187C" modified="2005-04-26" version="1">MEEYEYGHEGALQKFLENGRKPQPTYVELLPPASAAEHADLDRRWKLLMLSRRVSGMQDLLESTAGANLAIKEDRLLKRTGAQFTQTIWPVHYLPNITWITEPKHEKMAFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="106" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BA54</accession>
    <accession>C8VPW5</accession>
    <name>Q5BA54_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Xenobiotic compound monooxygenase, DszA family (AFU_orthologue AFUA_3G15040)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_02576</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NtaA/SnaA/DszA monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF87132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_660180.1">
        <property type="nucleotide sequence ID" value="XM_655088.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BA54"/>
    <dbReference type="GeneID" id="2875173"/>
    <dbReference type="KEGG" id="ani:ANIA_02576"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN2576"/>
    <dbReference type="eggNOG" id="ENOG502QSR6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022256_0_0_1"/>
    <dbReference type="InParanoid" id="Q5BA54"/>
    <dbReference type="OMA" id="HGLKEQI"/>
    <dbReference type="OrthoDB" id="5561043at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="entry name" value="Luciferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051260">
        <property type="entry name" value="Diverse_substr_monoxygenases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016215">
        <property type="entry name" value="NTA_MOA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03860">
        <property type="entry name" value="FMN_nitrolo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30011">
        <property type="entry name" value="ALKANESULFONATE MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30011:SF41">
        <property type="entry name" value="XENOBIOTIC COMPOUND MONOOXYGENASE, DSZA FAMILY (AFU_ORTHOLOGUE AFUA_3G15040)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000337">
        <property type="entry name" value="NTA_MOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="Bacterial luciferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Luciferase-like" evidence="2">
        <location>
            <begin position="39"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00033748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF87132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="481" mass="53274" checksum="A0E41E3D0DB0082B" modified="2005-04-26" version="1">MAETKGKKQIILNAFVMNTPAHMAPGQWRHPRNKTADYTKLSFWTDLAQLLDDAGFHAMFIADTLGPYDVYKGPANVVPALASGAQYPVNDPMYLVPAMASTTKNLIFGVTASLTYEQPYSLARRLSTVDHLSGGRVAWNIVTSYLDSAARNHGLDEQIPHDERYNRAHEYMDVLYKLWEGSFRDDAVVKDRESGVYIAPDAVRQIHHVGKYFKVPGPHFCEPSPQRTPFLFQAGVSEAGNGFGGKHGEAIFVAGQTPEGVRSTVESIRRVAASEGRDPNHIKVIVGITLIVAATDEEAYAKRDEYLKYADHEGVLALFGGWTGIDLSKYEDDADFRFADETKVASIVKRWASTVPGTDNLPWTKRRIVEFLSVGGIQTKIIGSGKTVADELERWVEISGVDGFNLAHITNPGSFEDIIEFLLPELRTRGLFRETVAKEGATARETYLGVGQVRLPEDHPGTTQHGEFNPKLIRCTMAYPT</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2010-10-05" modified="2025-04-09" version="100" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BA58</accession>
    <accession>C8VPV9</accession>
    <name>DPP5_EMENI</name>
    <protein>
        <recommendedName>
            <fullName>Probable dipeptidyl-peptidase 5</fullName>
            <ecNumber>3.4.14.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Dipeptidyl-peptidase V</fullName>
            <shortName>DPP V</shortName>
            <shortName>DppV</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">dpp5</name>
        <name type="ORF">AN2572</name>
    </gene>
    <organism>
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2009" name="Eukaryot. Cell" volume="8" first="738" last="746">
            <title>Differential roles of the ChiB chitinase in autolysis and cell death of Aspergillus nidulans.</title>
            <authorList>
                <person name="Shin K.S."/>
                <person name="Kwon N.J."/>
                <person name="Kim Y.H."/>
                <person name="Park H.S."/>
                <person name="Kwon G.S."/>
                <person name="Yu J.H."/>
            </authorList>
            <dbReference type="PubMed" id="19286987"/>
            <dbReference type="DOI" id="10.1128/EC.00368-08"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Extracellular dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase S9C family.</text>
    </comment>
    <dbReference type="EC" id="3.4.14.-"/>
    <dbReference type="EMBL" id="AACD01000043">
        <property type="protein sequence ID" value="EAA64677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF87122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_660176.1">
        <property type="nucleotide sequence ID" value="XM_655084.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BA58"/>
    <dbReference type="SMR" id="Q5BA58"/>
    <dbReference type="STRING" id="227321.Q5BA58"/>
    <dbReference type="ESTHER" id="emeni-q5ba58">
        <property type="family name" value="Prolyl_oligopeptidase_S9"/>
    </dbReference>
    <dbReference type="GlyCosmos" id="Q5BA58">
        <property type="glycosylation" value="8 sites, No reported glycans"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CBF87122">
        <property type="protein sequence ID" value="CBF87122"/>
        <property type="gene ID" value="ANIA_02572"/>
    </dbReference>
    <dbReference type="KEGG" id="ani:ANIA_02572"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN2572"/>
    <dbReference type="eggNOG" id="KOG2100">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008615_0_1_1"/>
    <dbReference type="InParanoid" id="Q5BA58"/>
    <dbReference type="OMA" id="YPVRYWD"/>
    <dbReference type="OrthoDB" id="416344at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.30:FF:000109">
        <property type="entry name" value="Dipeptidyl-peptidase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000028">
        <property type="entry name" value="S9 family peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42776:SF11">
        <property type="entry name" value="DIPEPTIDYL-PEPTIDASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42776">
        <property type="entry name" value="SERINE PEPTIDASE S9 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0031">Aminopeptidase</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0645">Protease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <keyword id="KW-0720">Serine protease</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000397821" description="Probable dipeptidyl-peptidase 5">
        <location>
            <begin position="19"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="1">
        <location>
            <position position="558"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="1">
        <location>
            <position position="641"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="1">
        <location>
            <position position="673"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="75"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="253"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="448"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="605"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="722" mass="79446" checksum="CA106CDDDAD0A2AA" modified="2005-04-26" version="1" precursor="true">MGALRWLSLAAAASSALALTPEQLISAPRRSEAIPNPSGNIAVFSSSQYSFDTHESSSAWNLLDLRSGKITPLTNDSNVSEIVWLNDSTLLYINGTNAQIPGGSELWVSGLSNFPSGYKAASLPASFSGLKAVTTKSGDIKFVAYAQSYRNGTAYNEELAETYLSSARIYDSIYVRHWDTYLTTTFNAVFSGTLKKTQHARYASAGSLKNLVAPIPNAESPYPPFGGSSDYDISADGKWVAYKSKAPDVPQANHTTAYIYLVPHDGSETPVPINGPGSAPEGIEGDSNNPVFSPDSKSLAYLQMKDPTYESDRRVIYIYDLASKKITPLATEWDRSPDSLKWTDKSTIVAGSEDEGSGNLFLIPVKKATGDFIPEKLTNGKYASAFYLASGNTLVVTGSTLYSSWYVDLVSLNPKRGTIKNLVSAHEIDPELSGLGPEDISDIWFAGNWTDIHAWVIYPEGFDKSKTYPLAFLIHGGPQGAWYNSWSSRWNPKVFADQGYVVVAPNPTGSTGYGDELTDAIQNNWGGAPYEDLVKAWEYVRDNLDYVDTDRGVAAGASYGGFMVNWIQGSDLGREFKALVTHDGTFVADAKISTEELWFMEREFNGTFWDVRDNYRRFDPSAPERILRFATPHLIIHNDLDYRLPVAEGLSLFNVLQERGVPSRFLNFPDENHWVTSPENSLVWHQQVLGWLNKYSGIAEDNEDAVTLEDTVVPVVNINPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="102" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BA64</accession>
    <accession>C8VPV3</accession>
    <name>Q5BA64_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">monoamine oxidase</fullName>
            <ecNumber evidence="2">1.4.3.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ANIA_02566</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a secondary aliphatic amine + O2 + H2O = a primary amine + an aldehyde + H2O2</text>
            <dbReference type="Rhea" id="RHEA:26414"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:58855"/>
            <dbReference type="ChEBI" id="CHEBI:65296"/>
            <dbReference type="EC" id="1.4.3.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the flavin monoamine oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.4" evidence="2"/>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF87111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_660170.1">
        <property type="nucleotide sequence ID" value="XM_655078.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BA64"/>
    <dbReference type="STRING" id="227321.Q5BA64"/>
    <dbReference type="GeneID" id="2875365"/>
    <dbReference type="KEGG" id="ani:ANIA_02566"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN2566"/>
    <dbReference type="eggNOG" id="KOG0029">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004498_0_3_1"/>
    <dbReference type="InParanoid" id="Q5BA64"/>
    <dbReference type="OMA" id="EWTRGAY"/>
    <dbReference type="OrthoDB" id="5046242at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097621">
        <property type="term" value="F:monoamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00448">
        <property type="entry name" value="YjgF_YER057c_UK114_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.660.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050703">
        <property type="entry name" value="Flavin_MAO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43563">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43563:SF14">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amine oxidase" evidence="4">
        <location>
            <begin position="332"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00048448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBF87111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="510" mass="55747" checksum="6C3D091CF3D2E32E" modified="2005-04-26" version="1">MTRVETVDLATTTAAYYAPATITSANSQVIHVAGQAEMTKDETVPADYESQVHLALLNLRKILILSGASVKDILKLTLYIVNYNSASRVHTRHLKRFLAGHRPAITLVPVARLAAPAWLFEVDAVAVRPASAVPRSLTGTANMGKLDVQCCVRASTSRVISRVYALAKRFGVEILEQNTTGLCVLQDVDGDCSTFEYGELPKVFVLSSSSERYRPDPRYGRSRLPLSIQFVLETQSGIPMTFEAYLWSRSAGKETLATSAVWIRAMLGQDLRDISALWFIAYCKAGGGLLQMRSDRKGGGQHLRIRQGMQMISKSCPQDDGLLPQAPRAEAAVGRVLQLRLLHKAMMIFRTPFWVEKGYCGLIQSFASPASVIRHTSSLPDKKYILTCFMASDLGRAWAALPTDGRKAALIKQIGKLFDAKTEAAGHLVDLVIYEWVNDPYSGWGCPCIALTPGVMDAVGETIREPAGNLHFAGTEAAVRWRGYMEGAIESGERAAAEVIQKLNAASARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="115" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BAA9</accession>
    <accession>C8VPK0</accession>
    <name>Q5BAA9_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Endosomal sorting complex protein TSG101, putative (AFU_orthologue AFUA_3G14380)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ANIA_02521</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ubiquitin-conjugating enzyme family. UEV subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF87017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_660125.1">
        <property type="nucleotide sequence ID" value="XM_655033.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BAA9"/>
    <dbReference type="FunCoup" id="Q5BAA9">
        <property type="interactions" value="556"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5BAA9"/>
    <dbReference type="GeneID" id="2874739"/>
    <dbReference type="KEGG" id="ani:ANIA_02521"/>
    <dbReference type="eggNOG" id="KOG2391">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017548_2_1_1"/>
    <dbReference type="InParanoid" id="Q5BAA9"/>
    <dbReference type="OMA" id="YMNFPQP"/>
    <dbReference type="OrthoDB" id="306304at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000813">
        <property type="term" value="C:ESCRT I complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008333">
        <property type="term" value="P:endosome to lysosome transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072666">
        <property type="term" value="P:establishment of protein localization to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043162">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11685">
        <property type="entry name" value="UEV_TSG101-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052070">
        <property type="entry name" value="ESCRT-I_UEV_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037202">
        <property type="entry name" value="ESCRT_assembly_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017916">
        <property type="entry name" value="SB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008883">
        <property type="entry name" value="UEV_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23306:SF3">
        <property type="entry name" value="TUMOR SUPPRESSOR PROTEIN 101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23306">
        <property type="entry name" value="TUMOR SUSCEPTIBILITY GENE 101 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05743">
        <property type="entry name" value="UEV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09454">
        <property type="entry name" value="Vps23_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140111">
        <property type="entry name" value="Endosomal sorting complex assembly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51312">
        <property type="entry name" value="SB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51322">
        <property type="entry name" value="UEV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="5 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="UEV" evidence="10">
        <location>
            <begin position="14"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="SB" evidence="9">
        <location>
            <begin position="483"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="156"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="285"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="160"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="171"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="200"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="222"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="235"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="250"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="286"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CBF87017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="565" mass="61738" checksum="3D3E025A98028217" modified="2005-04-26" version="1">MASVPQRTLNWLYSVLIRDHYDPKQTYQDPNRTYYDVANVLAKFPTLAPETAVYTYENGFSALLLQLSGTLPVTFRGTVYKFPIALWIPNTYPREPPIVYVKPTQDMVVRVGQHVTLEGRVYHHYLAHWGGAWERSSLLDLLSILQDVFAKEPPVKYKQQHPVPQQAQPVQTPPPRPPLPPELSNTFSYTPSPQLSSLRPPQPASRTPPPPPPKPGQLSSPTGLQQQIAPAQHNTPPPLPPLPPKEQSSRQHISPAQASISNNKPEILTVYLIIFLGAHILRHNSSHSSATPPQFQGPTHAAPHPAYHRQPPPAQVHLQLPHHGPTQAAPTSQPPAPRPKPETEDLLTSPFELELPSFTPTGPAPPIPPNPEKDALLQAVSKALTETLHANNAHSESAAHSLASQSHSLHATIATLQAEISSLKNLNSTLESNTSILTQSLHRADAVIADAQSRVSTAQSSSSSDSSSSSGLPPIDDILVAPTVVGKQLYDLVAEERGIQQALYALQAALVKGVIGVDTWSRHTRGLAREAFLKRALIRKIGKARENSPVICLDKFTLDYGTVYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="111" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BAD3</accession>
    <accession>C8VPH4</accession>
    <name>Q5BAD3_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Palmitoyl-protein thioesterase 1</fullName>
            <ecNumber evidence="2">3.1.2.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Palmitoyl-protein hydrolase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ANIA_02497</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the palmitoyl-protein thioesterase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.22" evidence="2"/>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF86972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_660101.1">
        <property type="nucleotide sequence ID" value="XM_655009.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BAD3"/>
    <dbReference type="STRING" id="227321.Q5BAD3"/>
    <dbReference type="ESTHER" id="emeni-q5bad3">
        <property type="family name" value="Palmitoyl-protein_thioesterase"/>
    </dbReference>
    <dbReference type="GeneID" id="2874815"/>
    <dbReference type="KEGG" id="ani:ANIA_02497"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN2497"/>
    <dbReference type="eggNOG" id="KOG2541">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050129_0_1_1"/>
    <dbReference type="InParanoid" id="Q5BAD3"/>
    <dbReference type="OMA" id="KFVMVMF"/>
    <dbReference type="OrthoDB" id="10263094at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000107">
        <property type="entry name" value="Palmitoyl-protein thioesterase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002472">
        <property type="entry name" value="Palm_thioest"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11247:SF8">
        <property type="entry name" value="PALMITOYL-PROTEIN THIOESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11247">
        <property type="entry name" value="PALMITOYL-PROTEIN THIOESTERASE/DOLICHYLDIPHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02089">
        <property type="entry name" value="Palm_thioest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00414">
        <property type="entry name" value="PPTHIESTRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010190164" description="Palmitoyl-protein thioesterase 1" evidence="9">
        <location>
            <begin position="27"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBF86972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="323" mass="35977" checksum="F1F116A25690EEDD" modified="2005-04-26" version="1">MRPLAYTSLVALPLLTAAFPASPASSEFTPLPLVIWHGLGDDYTRSGLRQVASLAESTNPGTYVHIIHIGDSASSDRQATFLGNVTEQLSTVCAQLAAEPILSTAPAINALGFSQGGQFLRAYVERCNNPPVRNLVTFGSQHNGIFEFQACSWGDFVCRGAEALLRVGRWSNLVQSRFVPAQYFRDPAELGEYLENSNFLADVNNERVLKNATYKKNLSTLNRFAMFMFEDDTIVHPKESSWFAEVNTTTGEVTPLRERDIYKEDWLGLRVLDEKGALDFKTLSGEHMQLAEEDLVEVFEKYFGPVEVDLPPAQFHLVNQEGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="136" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BAG4</accession>
    <accession>C8VP87</accession>
    <name>Q5BAG4_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS glucose transporter, putative (AFU_orthologue AFUA_3G14170)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ANIA_02466</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF86914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_660070.1">
        <property type="nucleotide sequence ID" value="XM_654978.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BAG4"/>
    <dbReference type="SMR" id="Q5BAG4"/>
    <dbReference type="STRING" id="227321.Q5BAG4"/>
    <dbReference type="GeneID" id="2874744"/>
    <dbReference type="KEGG" id="ani:ANIA_02466"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN2466"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_12_1"/>
    <dbReference type="InParanoid" id="Q5BAG4"/>
    <dbReference type="OMA" id="VTCVLVY"/>
    <dbReference type="OrthoDB" id="4142200at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd17356">
        <property type="entry name" value="MFS_HXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000026">
        <property type="entry name" value="MFS quinate transporter QutD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF7">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="122"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="273"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="313"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="337"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="385"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="421"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="452"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="9"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBF86914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="536" mass="58877" checksum="AABEF68865646F9A" modified="2005-04-26" version="1">MAIGNIYVIAAIAVIGGGLFGFDISSMSAIINTDAYLCYFQQGPLKTNDKGEQVCSGPTADVQGGITAAMPGGSWLGALVSGFLSDIFGRKTTIQIGSVIWCIGSIIVCAAQNIPMLIVGRIINGFSVGICSAQVPVYISELAPPTKRGRLVGLQQWAITWGIMIMFYISYGTSYIDGTAAFRIPWGLQMIPAVLLFFGMMVLPESPRWLARKDRWEECLAVLTLVHGHGDPNAPFVVREYEEIKAMCEFERNNADVSYLELIKPNMINRTHVGVFTQIWSQLTGMNVMMYYITYVFAMAGLQGNNLLVSSSIQYVINVVMTIPAILWVDRWGRRPTLLLGAAGMLAFLFANGGLMSSYGHPAPPGGLDGIEQQSWIVRGPPSKAVIACTYLFVAVYAISWGPVSWVYPPELFPLRVRGKANALCTSSNWAFNFALAYFVPPAFVNIQWKVYIIFGVFCTAMFLHVFFMFPETAGKTLEDVEGIFTNPAGIKYIGTPAWKTKNERGRAAMLEQTGFDVDEEKRAEAVAVHEESQPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="112" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BAS6</accession>
    <accession>C8VNF8</accession>
    <name>Q5BAS6_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Zn(II)2Cys6 transcription factor (Eurofung)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ANIA_02354</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF86674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_659958.1">
        <property type="nucleotide sequence ID" value="XM_654866.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BAS6"/>
    <dbReference type="FunCoup" id="Q5BAS6">
        <property type="interactions" value="582"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5BAS6"/>
    <dbReference type="GeneID" id="2875169"/>
    <dbReference type="KEGG" id="ani:ANIA_02354"/>
    <dbReference type="eggNOG" id="ENOG502QRM1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041189_0_0_1"/>
    <dbReference type="InParanoid" id="Q5BAS6"/>
    <dbReference type="OMA" id="FHGDEYW"/>
    <dbReference type="OrthoDB" id="3546279at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052400">
        <property type="entry name" value="Zn2-C6_fungal_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47657">
        <property type="entry name" value="STEROL REGULATORY ELEMENT-BINDING PROTEIN ECM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47657:SF10">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="136"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="171"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="187"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBF86674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="607" mass="67662" checksum="A595A83A9C772FF9" modified="2005-04-26" version="1">MGLFENLPLLLGSSHKACQSLVVAIPAITAHAQIQMCQGGPSLQPICTSSCDLKAALWSREPALLACIVLWSWFTKNEEREAVQEWDPQVLEIVAKPQYHATSALNGDSCAAADTGLNSQRARKRHRARHHKSRLGCFSCKARRVKCDEVRPVCGSCSSREEACVFPDPSAASLKPTSSSLQRRNLPRSWSSGSPRPVSSYLETWEEPTSRRVAVSAPEAHIDLRMDDLLSMQFFHLHTAQEMSLHAKRSMVWQRVIPRLAGKHHYLMHLLIALGGIHLITHRLKQSSGEDYDSSTVDLWSILNHYQRGLQDFRKEVAILSDANAEAVYAGSLLLVAFVYASLQVPELHEAFSKTESASVPYTPTLHKQTLPPIDRLEVNWLHLIRGVSTVIQSHWPALKSSCLRPMVLHFHGDEYWKEVPFDSSLPNLNHCSLPLQVFSRGAFQAVTDLRAFHSTIQLNDGSELHLAPISSPNTSEGSVDGPSRAIDVLQNIYSRVMSVFQCTANELGFPDDVEIQYNLEEAAVLSWPSLIPEAFIGLLEIDGAAGLAWGLSLTILAHFYVVNALVNRWYLDAFKEEILRIQRSVSTLRVADLDRLLIWPVKVATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BCD7</accession>
    <accession>C8VPF2</accession>
    <name>Q5BCD7_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ANIA_01793</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF85573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_659397.1">
        <property type="nucleotide sequence ID" value="XM_654305.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BCD7"/>
    <dbReference type="STRING" id="227321.Q5BCD7"/>
    <dbReference type="GeneID" id="2874809"/>
    <dbReference type="KEGG" id="ani:ANIA_01793"/>
    <dbReference type="HOGENOM" id="CLU_1468143_0_0_1"/>
    <dbReference type="InParanoid" id="Q5BCD7"/>
    <dbReference type="OrthoDB" id="3004402at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF85573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="184" mass="20362" checksum="88119FB2BCEC521A" modified="2005-04-26" version="1">MTPPTTLPTALHPRAAHITQSVHEYLEGTYPFSSPETKYAFYEMDFPRFMALLAPSGRIERLESAALFVSLTAILDDAFSQMSISESRQIGAKLLDIMRGVALADVLNPLEKILGKVVEDMNAQSPELAKDVLDGAVALFLAQTDKARLEITQLDEYFEFQFRDVGGDLSGPSSTASRKRRSDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="120" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BCU2</accession>
    <accession>C8VNI4</accession>
    <name>Q5BCU2_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Aminopeptidase</fullName>
            <ecNumber evidence="11">3.4.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">ANIA_01638</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="17">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9 11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9 11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the peptidase M1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.-" evidence="11"/>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF85271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_659242.1">
        <property type="nucleotide sequence ID" value="XM_654150.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BCU2"/>
    <dbReference type="SMR" id="Q5BCU2"/>
    <dbReference type="FunCoup" id="Q5BCU2">
        <property type="interactions" value="1011"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5BCU2"/>
    <dbReference type="MEROPS" id="M01.007"/>
    <dbReference type="GeneID" id="2875356"/>
    <dbReference type="KEGG" id="ani:ANIA_01638"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN1638"/>
    <dbReference type="eggNOG" id="KOG1046">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003705_0_1_1"/>
    <dbReference type="InParanoid" id="Q5BCU2"/>
    <dbReference type="OMA" id="MMEYVAI"/>
    <dbReference type="OrthoDB" id="10031169at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000328">
        <property type="term" value="C:fungal-type vacuole lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061957">
        <property type="term" value="C:NVT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
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        <property type="term" value="F:zinc ion binding"/>
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        <property type="term" value="P:cytoplasm to vacuole targeting by the NVT pathway"/>
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        <property type="term" value="P:proteolysis"/>
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        <property type="entry name" value="M1_APN-Q_like"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
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        <property type="entry name" value="Aminopeptidase_N-like_N"/>
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        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
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        <property type="entry name" value="ERAP1-like_C_dom"/>
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        <property type="entry name" value="M1_APN-typ"/>
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        <property type="entry name" value="Peptidase_M1"/>
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        <property type="entry name" value="Peptidase_M1_aminopeptidases"/>
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        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
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        <property type="entry name" value="PROTEASE M1 ZINC METALLOPROTEASE"/>
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        <property type="entry name" value="PUROMYCIN-SENSITIVE AMINOPEPTIDASE-RELATED"/>
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        <property type="entry name" value="ALADIPTASE"/>
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        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
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        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 11" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 9 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3 11" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9 11" id="KW-0862">Zinc</keyword>
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        <location>
            <begin position="26"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M1 membrane alanine aminopeptidase" evidence="13">
        <location>
            <begin position="246"/>
            <end position="463"/>
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    </feature>
    <feature type="domain" description="ERAP1-like C-terminal" evidence="14">
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            <begin position="537"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
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    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="319"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
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    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
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    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="341"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="10">
        <location>
            <position position="404"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
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        <source>
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        <source>
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    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
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            <dbReference type="Pfam" id="PF11838"/>
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            <dbReference type="Pfam" id="PF17900"/>
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    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CBF85271.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="883" mass="98004" checksum="A7FE6D64F361ECF4" modified="2005-04-26" version="1">MCGTRRAEAAGSTNVPGREVLPTNVKPTHYDLTLEPNFETFKYDGTVIIDLQVAEDTTSISLNSTEIDIHTATVSAQGSVVSSSPEILLNKDKQEATIKFSETISAGSSAQLKLTFTGTLNDNMAGFYRSSYKTPQGETKYIASTQMEPTDARRAFPCFDEPALKAKFTVSLIADKSMTCLGNMDVASEQELEGGKKIVKFNTSPVMSTYLVAFIVGHLNYIETKNFRVPIRVYATPDQDIEHGRFSLELAAKTLAFYEKAFDSEFPLPKMDMVAVPDFSAGAMENWGLITYRIVDVLLDEKTSSASRKERIAETVQHELAHQWFGNLVTMDFWDGLWLNEGFATWMSWYSCNSFYPEWKVWQTYVIDNLQSALSLDSLRSSHPIEVPVKRADEINQIFDAISYSKGSSVLRMISKYLGEDIFLQGVRNYIKKHAYGNTQTGDLWSALANASGKPVEEVMDIWTKNVGFPVVTVSENPTSSSIKVKQNRFLRTGDVRPEEDTTIFPVMLGLRTKQGVDEDTLLSEREGEFKLPDLDFYKLNADHSAIYRTSYTPERLTKLGEAAKAGLLTVEDRAGMIADAGALAASGYQSTSGLLSLLAGFDSEPEFVVWNEILTRVGALRAAWVFEDAQTKDALEGFQRALVSDKAHTLGWQFSENDGHIIQQFKALLFSAAGNAGDKTVVQAAQDMFQRFAAGDISAIHPNIRGSVFSIVLKNGGKKEYDVVYDRFRNAPTSDEKTTALRCLGAAEDPELIQRTLGLALGDEVKNQDIYMPLGGLRNHAAGIDARWAWMKDNWDTLYQRLPPGLGMLGTVVQICTASFCTEEQLKGVQNFFANKDTKGYDRAIEQSLDAIRAKISWVQRDRADVGSWLKSKGYLPGNGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="102" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BD66</accession>
    <accession>C8VMP6</accession>
    <name>Q5BD66_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Myb-like DNA-binding domain protein (AFU_orthologue AFUA_8G05190)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_01514</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CBF85020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_654026.1"/>
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        <property type="component" value="Chromosome VII"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018465">
        <property type="entry name" value="Scm3/HJURP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15992">
        <property type="entry name" value="HOLLIDAY JUNCTION RECOGNITION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15992:SF5">
        <property type="entry name" value="HOLLIDAY JUNCTION RECOGNITION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10384">
        <property type="entry name" value="Scm3"/>
        <property type="match status" value="1"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="141"/>
            <end position="228"/>
        </location>
    </feature>
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        <location>
            <begin position="250"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="438"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="410"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="446"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF85020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="579" mass="64125" checksum="47442FACBD4BFF29" modified="2005-04-26" version="1">MGSPLKRKRLYLWSGADDEYETSDIDLQEARTQNDLRLKSIFEGIFEKYGRDFTDVGDEIDLQTGKITVNNGHIDALEVEGNGYGDWLSDARPQAPRHVLAERTDYEGKPARLALDADAWGAEDTALEGDHDLQHPGRRTVHLLSHMRPGSRRGLGETTETDSDQGAAGDGEDRATSEAEDDRSSVDSLLGTALSIPAQKVGKTTKGETGTEKAIPPHDGSHQYQAAHTERLDETVDPIWRVPEISAKFTTPTLPSRPRPNPKPVINNAVRSQSPPGASSVWALSGTRKRDTDVVKKIKQKGSPKRRVKHHSSPDAVWDWSFADAPDGSESDDPLQEDYVPSPTPKDSVYIREKRKGPFSAGAAQKTCSFCKRIFSRKAYDMHLKDVLANPADNEHDSVELKRQLATVTGDGTTESAPGATNRSPAPAGLIVRITNTPREPDSEAGQRTNHESTPTGSKRARTVLGPQEARLIIQMRHIQGMKWKEISDHFPQKKPANIQAWHHVHWKQRKANPPRLSGPWSKAELEKLEILKDQPELTWPGIRAEFPGRLLAEIEFKLLQLWAGDNVSQPLRSASPAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="113" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BDP8</accession>
    <accession>C8VS48</accession>
    <name>Q5BDP8_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">glucan 1,3-beta-glucosidase</fullName>
            <ecNumber evidence="13">3.2.1.58</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Exo-1,3-beta-glucanase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Exo-1,3-beta-glucanase A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">ANIA_01332</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="20">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Beta-glucanases participate in the metabolism of beta-glucan, the main structural component of the cell wall. It could also function biosynthetically as a transglycosylase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>Successive hydrolysis of beta-D-glucose units from the non-reducing ends of (1-&gt;3)-beta-D-glucans, releasing alpha-glucose.</text>
            <dbReference type="EC" id="3.2.1.58"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.58" evidence="13"/>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF87701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_658936.1">
        <property type="nucleotide sequence ID" value="XM_653844.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BDP8"/>
    <dbReference type="CAZy" id="GH5">
        <property type="family name" value="Glycoside Hydrolase Family 5"/>
    </dbReference>
    <dbReference type="GeneID" id="2877110"/>
    <dbReference type="KEGG" id="ani:ANIA_01332"/>
    <dbReference type="eggNOG" id="ENOG502RW7W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004624_2_0_1"/>
    <dbReference type="InParanoid" id="Q5BDP8"/>
    <dbReference type="OMA" id="TIDSQFW"/>
    <dbReference type="OrthoDB" id="1887033at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004338">
        <property type="term" value="F:glucan exo-1,3-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050386">
        <property type="entry name" value="Glycosyl_hydrolase_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297:SF1">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE I_II-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297">
        <property type="entry name" value="GLUCAN ENDO-1,6-BETA-GLUCOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="9 16" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 17" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010317662" description="glucan 1,3-beta-glucosidase" evidence="17">
        <location>
            <begin position="19"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="18">
        <location>
            <begin position="97"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00036824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00041261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00041265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CBF87701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="408" mass="45160" checksum="BBB00DF4EABDF376" modified="2005-04-26" version="1">MHPLHLLTTALLTTCTSSLPSSLSHQRPKFDDSYTKAFQPFSWSSAKVRGANLGGWLVQEASIDTAFWNTYAPDAPDEWTLCTTLGLKCASVLEHRYATFITTSTIDTLASVGVNLLRIPTTYAAWINLPGSGLYSGNQKAYLRKITEYAITNYNMHIVIDVHSLPGGLNGLDIGEKKGNWGWFYNATAWNHSLEVVDAVVEFIFTSSSPRSFTLEPMNEPTDRNRDDDLTMAVFGTPAALSDRAAAYVMSFWKAVLERVRTLESGIGSGISGTIPVAFQSFKLPSYWGGNFTADSNVVFDVHNYYFEGRNTTSENLPTYMRSDAEEKSITGNGVPVYVGEWAIQAAYNNSFALREKNLNAGLSIWEEYMQGSAYWTAKFEGTDEVNGEGNKSDYWSFGGFIELGYLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="122" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BE15</accession>
    <accession>C8VSS7</accession>
    <name>Q5BE15_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CP-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ANIA_01215</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
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        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
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        <property type="entry name" value="TRAFAC_YlqF/YawG_RiboMat"/>
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        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN-LIKE 3 HOMOLOG"/>
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        <property type="entry name" value="GN3L_Grn1"/>
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    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
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        <property type="entry name" value="G_CP"/>
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    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="CP-type G" evidence="9">
        <location>
            <begin position="187"/>
            <end position="372"/>
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    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="72"/>
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    <feature type="region of interest" description="Disordered" evidence="8">
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            <begin position="136"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
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            <begin position="1"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
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            <begin position="26"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
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            <begin position="36"/>
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            <begin position="72"/>
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            <begin position="143"/>
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            <dbReference type="ARBA" id="ARBA00004123"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
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            <dbReference type="ARBA" id="ARBA00023242"/>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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            <dbReference type="PROSITE" id="PS51721"/>
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            <dbReference type="EMBL" id="CBF87920.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="544" mass="59818" checksum="CEF69E24E458F2C1" modified="2005-04-26" version="1">MVKLGKTSKRTPVRLRHKIEKASAAKQRKQRKLAKKNPEWRSKIKKDPGIPNLFPHKEKMLQEIEERRRMKAEEQARIREEARARRIAAKQGGDATAESTNPIPVDLEGDDILDDEMDEDMGDDANPMAALLASARARAAEYEGSESDEDQDQMDEDDEMEGMSEDDEVADEDGVPALVAAGKETSRRAFDKVFKKVVEAADVILYVLDARDPEGTRSKEVEREIMAADGGQKRLILILNKIDLVPPPVLKNWLIHLRRYFPTLPLKASNGAGNAHSFDHKQLSIKGTSETLFRALKTYAQNKGLKRAISVGVIGYPNVGKSSVINALTARMNKGSSNACPTGAEAGVTTNLREVKLDSKLKLIDSPGIVFPNTSEKKGKKKQDDQARLILLNAIPPKHIEDPIPAVNLLLKRLSSSEGLLQKLLQVYGIPTLYSGTSTTDRTNDFLIQVARKRGRLGKRGVPNLEAAAMTVINDWRDGRIQGWATPPVLKVVDTTADGATGDANNSAAAPGVDTRQVVSEWAAEFKIEGLWGDGNAEDEAMEE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-03-20" modified="2025-06-18" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BEG1</accession>
    <accession>C8VTN7</accession>
    <name>CHS7_EMENI</name>
    <protein>
        <recommendedName>
            <fullName>Chitin synthase export chaperone</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">chs7</name>
        <name type="ORF">AN1069</name>
    </gene>
    <organism>
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Chaperone required for the export of the chitin synthase chs3 from the endoplasmic reticulum.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Interacts with chs3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CHS7 family.</text>
    </comment>
    <dbReference type="EMBL" id="AACD01000016">
        <property type="protein sequence ID" value="EAA66187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF88215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_658673.1">
        <property type="nucleotide sequence ID" value="XM_653581.1"/>
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            <fullName evidence="1">Uncharacterized protein</fullName>
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        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
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            <taxon>Eurotiomycetidae</taxon>
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        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
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                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
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            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
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                <person name="Cornell M.J."/>
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                <person name="Visser J."/>
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        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
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        <source>
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        <source>
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    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
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                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
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                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
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                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
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                <person name="Vienken K."/>
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                <person name="Penalva M.A."/>
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                <person name="Denning D.W."/>
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                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
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            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
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                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
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            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001308">
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    <dbReference type="STRING" id="227321.Q5BFH6"/>
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    <dbReference type="VEuPathDB" id="FungiDB:AN0704"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="OMA" id="RFFNGWR"/>
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        <property type="component" value="Chromosome VIII"/>
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        <property type="entry name" value="Sfi1_dom"/>
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    <dbReference type="Pfam" id="PF08457">
        <property type="entry name" value="Sfi1"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sfi1 spindle body" evidence="2">
        <location>
            <begin position="367"/>
            <end position="935"/>
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            <end position="197"/>
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            <begin position="984"/>
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            <begin position="1040"/>
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            <begin position="246"/>
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            <begin position="985"/>
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        <source>
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        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
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</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BFK2</accession>
    <accession>C8VRR7</accession>
    <name>Q5BFK2_EMENI</name>
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        <recommendedName>
            <fullName evidence="4">DUF1754-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_00678</name>
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    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
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            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
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    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF89004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_653190.1"/>
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    <dbReference type="VEuPathDB" id="FungiDB:AN0678"/>
    <dbReference type="eggNOG" id="KOG3410">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098435_1_1_1"/>
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    <dbReference type="OrthoDB" id="205403at2759"/>
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        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013865">
        <property type="entry name" value="FAM32A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13282">
        <property type="entry name" value="PROTEIN FAM32A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13282:SF6">
        <property type="entry name" value="PROTEIN FAM32A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08555">
        <property type="entry name" value="FAM32A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="32"/>
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        </location>
    </feature>
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            <begin position="45"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF89004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="140" mass="15240" checksum="34CC08557980DAA8" modified="2005-04-26" version="1">MDEYSAGGGGKLKLKGAKVSDGRVKKKKSKKSSSAGTGATTGVGEKVEEKRSEDAAAEERARSVSGGAEGEDESHSTGTSTPTQPAKTEAERKHEELRRKRIQERLKREGVKTHKERVEELNKYLSRLSEHHDMPKIGPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BG20</accession>
    <accession>C8VSW6</accession>
    <name>Q5BG20_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7136 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_00510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF89339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_658114.1">
        <property type="nucleotide sequence ID" value="XM_653022.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BG20"/>
    <dbReference type="GeneID" id="2876284"/>
    <dbReference type="KEGG" id="ani:ANIA_00510"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN0510"/>
    <dbReference type="HOGENOM" id="CLU_058866_1_0_1"/>
    <dbReference type="InParanoid" id="Q5BG20"/>
    <dbReference type="OMA" id="AMAFNVT"/>
    <dbReference type="OrthoDB" id="4490227at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055560">
        <property type="entry name" value="DUF7136"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23584">
        <property type="entry name" value="DUF7136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010164939" description="DUF7136 domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7136" evidence="2">
        <location>
            <begin position="19"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF89339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="296" mass="31712" checksum="DB82979197EE9790" modified="2005-04-26" version="1">MVRVSWLLLGLLACWATAESNKTEINLIFPREGTFAPMHSMPVVFAIQNPSVAKELHATIQYGVRPKGGGSNETVWSYSDELANVPANATTYFSSTSLGNMLNTTGSWEFFWNLYWLNCSQSNDPAYYDSKYPWVLGADGLNQDAVLDGFHLSSYLVTAKYLFFDTKEGGTAVNLTTLTSDNQCSEASGFVVPALVNTLDIPRDFPDHNSLPSTCAQLANSTSTSATKASPCRVSISPEAEASILADAECHNTLFPTSGCPDKTPGDDVAAGLDHGRAVWAAITLAFALAVGLVGC</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-05-10" modified="2026-01-28" version="130" xmlns="https://uniprot.org/uniprot">
    <accession>Q9Y8H3</accession>
    <accession>C8VN63</accession>
    <accession>Q5BAW6</accession>
    <name>GLGB_EMENI</name>
    <protein>
        <recommendedName>
            <fullName>1,4-alpha-glucan-branching enzyme</fullName>
            <ecNumber evidence="2">2.4.1.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Glycogen-branching enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">be1</name>
        <name type="ORF">AN2314</name>
    </gene>
    <organism>
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="1999-04" db="EMBL/GenBank/DDBJ databases">
            <title>Emericella nidulans putative branching enzyme.</title>
            <authorList>
                <person name="Kobayashi T."/>
                <person name="Tanaka A."/>
                <person name="Matsuno A."/>
                <person name="Kato M."/>
                <person name="Tsukagoshi N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Glycogen-branching enzyme participates in the glycogen biosynthetic process along with glycogenin and glycogen synthase. Generates alpha-1,6-glucosidic branches from alpha-1,4-linked glucose chains, to increase solubility of the glycogen polymer.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>Transfers a segment of a (1-&gt;4)-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain.</text>
            <dbReference type="EC" id="2.4.1.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan biosynthesis; glycogen biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="1">Localizes to glycogen granules in the cytoplasm.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.</text>
    </comment>
    <comment type="sequence caution" evidence="4">
        <conflict type="miscellaneous discrepancy">
            <sequence resource="EMBL-CDS" id="BAA78714" version="1"/>
        </conflict>
        <text>Probable sequencing error places a 'ESWIKTV' sequence at a wrong position.</text>
    </comment>
    <comment type="sequence caution" evidence="4">
        <conflict type="erroneous gene model prediction">
            <sequence resource="EMBL-CDS" id="EAA64425" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EC" id="2.4.1.18" evidence="2"/>
    <dbReference type="EMBL" id="AB026630">
        <property type="protein sequence ID" value="BAA78714.1"/>
        <property type="status" value="ALT_SEQ"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AACD01000038">
        <property type="protein sequence ID" value="EAA64425.1"/>
        <property type="status" value="ALT_SEQ"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF86590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9Y8H3"/>
    <dbReference type="SMR" id="Q9Y8H3"/>
    <dbReference type="FunCoup" id="Q9Y8H3">
        <property type="interactions" value="429"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q9Y8H3"/>
    <dbReference type="CAZy" id="CBM48">
        <property type="family name" value="Carbohydrate-Binding Module Family 48"/>
    </dbReference>
    <dbReference type="CAZy" id="GH13">
        <property type="family name" value="Glycoside Hydrolase Family 13"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CBF86590">
        <property type="protein sequence ID" value="CBF86590"/>
        <property type="gene ID" value="ANIA_02314"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AN2314"/>
    <dbReference type="eggNOG" id="KOG0470">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011131_2_2_1"/>
    <dbReference type="InParanoid" id="Q9Y8H3"/>
    <dbReference type="OMA" id="YEMHLGS"/>
    <dbReference type="OrthoDB" id="196493at2759"/>
    <dbReference type="UniPathway" id="UPA00164"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003844">
        <property type="term" value="F:1,4-alpha-glucan branching enzyme activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043169">
        <property type="term" value="F:cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd11321">
        <property type="entry name" value="AmyAc_bac_euk_BE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02854">
        <property type="entry name" value="E_set_GBE_euk_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000001">
        <property type="entry name" value="1,4-alpha-glucan branching enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000250">
        <property type="entry name" value="1,4-alpha-glucan-branching enzyme, chloroplastic/amyloplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1180:FF:000003">
        <property type="entry name" value="1,4-alpha-glucan-branching enzyme, chloroplastic/amyloplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006048">
        <property type="entry name" value="A-amylase/branching_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037439">
        <property type="entry name" value="Branching_enzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004193">
        <property type="entry name" value="Glyco_hydro_13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43651">
        <property type="entry name" value="1,4-ALPHA-GLUCAN-BRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43651:SF3">
        <property type="entry name" value="1,4-ALPHA-GLUCAN-BRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02806">
        <property type="entry name" value="Alpha-amylase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02922">
        <property type="entry name" value="CBM_48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000463">
        <property type="entry name" value="GlgB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword id="KW-0328">Glycosyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000188782" description="1,4-alpha-glucan-branching enzyme">
        <location>
            <begin position="1"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="340"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="395"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>(1,4-alpha-D-glucosyl)n</name>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>(1,4-alpha-D-glucosyl)n</name>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="2">
        <location>
            <position position="464"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; BAA78714." evidence="4" ref="1">
        <location>
            <begin position="34"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; BAA78714." evidence="4" ref="1">
        <original>N</original>
        <variation>NESWIKTV</variation>
        <location>
            <position position="60"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; BAA78714." evidence="4" ref="1">
        <original>K</original>
        <variation>KVK</variation>
        <location>
            <position position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P32775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="Q04446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="3">
        <source>
            <dbReference type="UniProtKB" id="Q6FJV0"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="684" mass="78419" checksum="D04B9091A92521BD" modified="2011-11-16" version="3">MTSTAPSDGTGIIDLDPWLEPFREAIKRRFDYVESWIKTVDEVEGGLDKFSKGYEKFGFNVSETGDITYREWAPNAIEAALVGDFNNWDTKANPMTRDNFGVWEIALPAKNGTPVIPHDSKVKITMVTRSGERIYRIPAWIKRVVQDLNVSPIYESVFWNPPKAERYNFQHARPKKPESLRIYEAHVGISSPDTRVATYKEFTANMLPRIKYLGYNAIQLMAIMEHAYYASFGYQVNNFFAASSRYGKPEDLKELVDTAHSMGLVVLLDVVHSHASKNVDDGLNMFDGSDHLYFHSGSKGQHELWDSRLFNYGNHEVLRFLLSNLRFWMEEYGFDGFRFDGVTSMLYTHHGIGTGFSGGYHEYFGPAVDDDGVMYLALANEMLHRLYPDCITVAEDVSGMPALCLPHGLGGVGFDYRLAMAIPDMYIKLLKEKSDNDWDIGNLAFTLTNRRHGEKTIAYAESHDQALVGDKSLMMWLCDKEMYTHMSVLTEFTPVIERGMALHKMIRLVTHALGGEGYLNFEGNEFGHPEWLDFPRAGNNNSFWYARRQLNLTEDHLLRYRFLNEFDRAMQLTESKYGWLHAPQAYISLKHEGDKVLVFERADLLWIFNFHPTESFTDYRVGVEQAGTYRVVLDTDDQAFGGLGRIDQGTRFFTTDMEWNGRRNYLQVYIPTRTALALALEETL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>C8V1D4</accession>
    <name>C8V1D4_EMENI</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ANIA_11523</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF71169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467135.1">
        <property type="nucleotide sequence ID" value="XM_050613296.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V1D4"/>
    <dbReference type="GeneID" id="74897096"/>
    <dbReference type="KEGG" id="ani:ANIA_11523"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN11523"/>
    <dbReference type="HOGENOM" id="CLU_3207615_0_0_1"/>
    <dbReference type="InParanoid" id="C8V1D4"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF71169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="45" mass="4799" checksum="6B873E35CBA05E08" modified="2009-11-03" version="1">MCVYVCECEQRAKYLAPVFSVAQPSTKPNTATALALVICHVGPTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>C8V1R4</accession>
    <name>C8V1R4_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ANIA_10796</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF69900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_663833.2">
        <property type="nucleotide sequence ID" value="XM_658741.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V1R4"/>
    <dbReference type="GeneID" id="2870810"/>
    <dbReference type="KEGG" id="ani:ANIA_10796"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN10796"/>
    <dbReference type="HOGENOM" id="CLU_1098494_0_0_1"/>
    <dbReference type="InParanoid" id="C8V1R4"/>
    <dbReference type="OMA" id="VYERQNW"/>
    <dbReference type="OrthoDB" id="4526473at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF69900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="253" mass="28955" checksum="0EE99C6113BE7943" modified="2009-11-03" version="1">MDEDLIQKYGPGMSFYRAQIKAAQRQKRLGGEVVLTRYCAALRELTLSNKLLEGKVKQLCSDSLRLTFDVTLLKRHMKAISGELLVTWQADILTRLVEVIYERHGWRMPGEVLVSDKYSLDRDTLSKIYVMAARKIKKETIMKKAVGLSEQYYLALQRYRTGEWFREVHSTTVARAKAPAARLFLTENWRSLLPCFARWLYLHGPFSKLGTVAVKSVFPRSLLGLNAPTRVLHENPSPRSAIKTSCNYTGVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C8V264</accession>
    <name>C8V264_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl-CoA:6-aminopenicillanic-acid-acyltransferase, putative (AFU_orthologue AFUA_3G12620)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_06775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF71434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_664379.2">
        <property type="nucleotide sequence ID" value="XM_659287.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V264"/>
    <dbReference type="STRING" id="227321.C8V264"/>
    <dbReference type="MEROPS" id="C45.001"/>
    <dbReference type="GeneID" id="2870305"/>
    <dbReference type="KEGG" id="ani:ANIA_06775"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN6775"/>
    <dbReference type="eggNOG" id="ENOG502RY9N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037787_1_0_1"/>
    <dbReference type="InParanoid" id="C8V264"/>
    <dbReference type="OMA" id="IEFYACL"/>
    <dbReference type="OrthoDB" id="189997at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042318">
        <property type="term" value="P:penicillin biosynthetic process"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.60.10">
        <property type="entry name" value="Penicillin V Acylase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047794">
        <property type="entry name" value="C45_proenzyme-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047801">
        <property type="entry name" value="Peptidase_C45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005079">
        <property type="entry name" value="Peptidase_C45_hydrolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040521">
        <property type="entry name" value="C45_proenzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34180:SF1">
        <property type="entry name" value="BETA-ALANYL-DOPAMINE_CARCININE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34180">
        <property type="entry name" value="PEPTIDASE C45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03417">
        <property type="entry name" value="AAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase C45 hydrolase" evidence="1">
        <location>
            <begin position="111"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF71434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="345" mass="38009" checksum="AB907659BD0289CF" modified="2009-11-03" version="1">MAVKQIVCSGTPYEIGHKHGSQASEEICRAIAFYAKMFAKHSNLDWPQVQELARDFDGLIKHRWPRYYEELKGIADGAKTDLIDIIALNVRTEIVFGRFSDGCTSLYYQNSEHSFQGQNWDWDTEQAVNLIQLTVIQQDLPTIKMITEAGIIGKIGLNSTGVGVCFNAIRAKGLDKTRIPVHLGLRIALESSSALQAVENLEKIGMASSAHILIGDATTAIGLEFTSSTFARIPVNQKGFIVHSNHMLLPHSGIDEPAWLEDSPVRVQTMSENIEKLQGTLSWASFGGLFKDESNYPCSINRAAGGGSDLATLFNIIMDLRTKRVEVIMGRPSDAAAERVILAFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2025-10-08" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>C8V2M4</accession>
    <name>C8V2M4_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Basic leucine zipper (bZIP) transcription factor atfB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ANIA_06849</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bZIP family. ATF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF71585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_664453.2">
        <property type="nucleotide sequence ID" value="XM_659361.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V2M4"/>
    <dbReference type="STRING" id="227321.C8V2M4"/>
    <dbReference type="GeneID" id="2870549"/>
    <dbReference type="KEGG" id="ani:ANIA_06849"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN6849"/>
    <dbReference type="eggNOG" id="KOG1414">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_863376_0_0_1"/>
    <dbReference type="InParanoid" id="C8V2M4"/>
    <dbReference type="OMA" id="SPPLQWP"/>
    <dbReference type="OrthoDB" id="295274at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903833">
        <property type="term" value="P:positive regulation of cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd14687">
        <property type="entry name" value="bZIP_ATF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000053">
        <property type="entry name" value="BZIP transcription factor AtfA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050946">
        <property type="entry name" value="AP-1_TF_bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11462">
        <property type="entry name" value="JUN TRANSCRIPTION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11462:SF35">
        <property type="entry name" value="TRANSCRIPTION FACTOR JRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0346">Stress response</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="10">
        <location>
            <begin position="204"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="104"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="139"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="180"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00068999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CBF71585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="322" mass="35391" checksum="2B135B28E36348DA" modified="2009-11-03" version="1">MVLSPSILLHISSQLVSLVTMSRTDSFLQQGVSYGNAGIISASELQRFQTSMYPSDIPNLAGNPFSLSEDNMWAPHPTTHPTINPSCIAAGGASDVHSYLTNHPFDELNHKQGPSNRRRSSAETELDQGSYRVRHGQVTPPSDHSPSTVYSVPSHDSKSAYLPSTIEGSSESPPKRRRSGSSNMSGSRGSTRASTSVEPTSPGDDKQEKTRARNRLAASKCRQKKKEQNHMLETRYEQEKMKNEELTRTVNSLRDAIVVAKDQLLAHSECGHESIKAYIQNMAKNISIQHEQFDFGTAPAQYGCHSERKPSGFGFDVHPPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>C8V3C6</accession>
    <name>C8V3C6_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Disulfide isomerase, putative (AFU_orthologue AFUA_2G10590)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ANIA_05970</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF70449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467033.1">
        <property type="nucleotide sequence ID" value="XM_050612326.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V3C6"/>
    <dbReference type="FunCoup" id="C8V3C6">
        <property type="interactions" value="94"/>
    </dbReference>
    <dbReference type="STRING" id="227321.C8V3C6"/>
    <dbReference type="GeneID" id="2870843"/>
    <dbReference type="KEGG" id="ani:ANIA_05970"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN5970"/>
    <dbReference type="eggNOG" id="KOG0191">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021868_0_0_1"/>
    <dbReference type="InParanoid" id="C8V3C6"/>
    <dbReference type="OMA" id="IFVYFYD"/>
    <dbReference type="OrthoDB" id="72053at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd02961">
        <property type="entry name" value="PDI_a_family"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052250">
        <property type="entry name" value="PDI_TMX3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46426">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE TMX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46426:SF1">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE TMX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002993047" evidence="7">
        <location>
            <begin position="21"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="671"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="8">
        <location>
            <begin position="31"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="8">
        <location>
            <begin position="230"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="186"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBF70449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="731" mass="82119" checksum="5D7FAF4004092528" modified="2009-11-03" version="1">MRVSLLTWSLLSLFSLPTFASHSEGSTPAQRLVKRADSDDSTPTLFNGVEVPPMKELTPENFAETVKDGYWFIKQYSPACPHCVAIAPTWQTLYEFYYTSNPLSAASTKQSDSWSLNSFEGFYNFHFAAMNCLAYGDLCKKLEIDGYPTFSLYHDGKQVERYDGAKTMEAFSEYIEEKLEAIKPGSRPAKGLKLPEPGDKAVDTKANPDTAASKDKDPEAGVKAGEKHNEKAAQHAAEMALENPANERDATSKSKQKAKAPVNPQGISVPLTAESFQKLVTPTDEPWFIKFYAPWCHHCQALAPNWAQMAKEMQHTLNVGEVNCEVERRLCKDARVTAFPTMYFFRGTERVEYNGLRGLGDLVSYANRAVEIRNGIQDVDAESFKALEETEDVIFLYFYDHATVSEDFEALERLALPLIGHAKLVKTDSAALAERFRISTWPRLLVSRSGRANYYNPIAPRDMRDIRQILNWMQTVWLPIVPELTASNARELMDGKFVVLGILSRSRANEFVEAKRELKNAALEWMDKQVQLFQLERQELRDAKQLRIEEAEDRNDQRALRAAKNMHVSIREDDKKQVRFAWVDGDFWERWLRTTYGIDVSKGERVIINDQDNRRYWDTASSGASIMASRTSILETIPLVIANPPKLTPKSTIGTFESIFFVSHAFITGHPILFVILLILSIAGVTYVARGRAHKRGIRGGILGIAGNAGGFLQLDGKEGLLNGGSTGKVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>C8V3J7</accession>
    <name>C8V3J7_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DEAD/DEAH box helicase, putative (AFU_orthologue AFUA_2G10820)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ANIA_10757</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF70556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467050.1">
        <property type="nucleotide sequence ID" value="XM_050612472.1"/>
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    <dbReference type="AlphaFoldDB" id="C8V3J7"/>
    <dbReference type="FunCoup" id="C8V3J7">
        <property type="interactions" value="98"/>
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    <dbReference type="STRING" id="227321.C8V3J7"/>
    <dbReference type="GeneID" id="74896586"/>
    <dbReference type="KEGG" id="ani:ANIA_10757"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN10757"/>
    <dbReference type="eggNOG" id="KOG4150">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000809_1_0_1"/>
    <dbReference type="InParanoid" id="C8V3J7"/>
    <dbReference type="OMA" id="GAVHLHQ"/>
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    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
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    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
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    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:nucleic acid binding"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0000318"/>
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    </dbReference>
    <dbReference type="CDD" id="cd17923">
        <property type="entry name" value="DEXHc_Hrq1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SF2_C_Hrq"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="CDT1_Gemini-bd-like"/>
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        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
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    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
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    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
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    <dbReference type="InterPro" id="IPR055227">
        <property type="entry name" value="HRQ1_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018973">
        <property type="entry name" value="MZB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47957">
        <property type="entry name" value="ATP-DEPENDENT HELICASE HRQ1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47957:SF3">
        <property type="entry name" value="ATP-DEPENDENT HELICASE HRQ1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08839">
        <property type="entry name" value="CDT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09369">
        <property type="entry name" value="MZB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22982">
        <property type="entry name" value="WHD_HRQ1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="4">
        <location>
            <begin position="408"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="5">
        <location>
            <begin position="631"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="29"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="87"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="107"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBF70556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="1210" mass="135179" checksum="9AAC6AB73B6926C6" modified="2009-11-03" version="1">MARQKTKKTASFTGAGPAENRNHAERTSSQHNLTTGVSGCALQVQQSAEDTNAARQKRKLDETVSETLNSQENIDDNVAPVEEESAQSKIAGSMSATKQPGKRRKSAASSERQQQPRKPSPPWPDHFKHLSRTHRALNLIYTFCCTRKHFATTFDNIKKAVQAQTGTELTIEDIARVRVLIPRAVRFEYVNEARLDVLSAGEREVKGWGGAIDNGNGDEMNGEADAKLDGVMYALLFEFLDGDLKKEKKSLTSGTRDKDEDLRMPVYSQKQMLGLIEKRNGKFADAVDAFLVRCEDEGVDAVERLEREKDGFIPVLPDIGSKEGLADGLSSKVRGPIPKDRKTMAEIIEEIRCLDWYTGQIVPDGHRAFDAQPAIYGDLRFALSQDLVNALYNTKGITRFYSHQAEAINHLHDGKNVIVSTSTSSGKSLIYQVPMLHELEQDSDSRGMYIFPTKALAQDQKRSMQELLQYLNSLQGTMVETFDGDTPMANRNLIRDEARIIFTNPDMLHITILPQESSWRTFLQNLKFVVVDELHVYNGLFGSHVALIMRRLRRICAAVGNRHVRFISCSATVANPEEHMRAIFGVDDVQLIDFDGSPCGRKEFLCWNTPFKDPGDPTSGRGDSVAEAARLFCQLILRGARVIAFCRIRKLCEVLLQAVRSECNRLERPEVGNMIMGYRGGYSPQDRRRIEAEMFQGQLLGIVATNALELGVDIGSLDAVITLGFPYSISNLRQQSGRAGRRNKDSLSILIGERYPTDQFYMRNPEELFSKPNCELQVDLTNELVLEGHVQCAAFELPIKPDDDQIYFGPQLSEFASTRLVRDAMGFYHCHERFRPQPSRCVPIRDTEDQHFAVIDTTNARNVVLEEVEASRAFFTLYEGGIFLHQGQTYLVKELNPDRFFARVVCVTVDWNTMQRDFTDIDPVETEHMRLITSSSPTKATKITDSSSTRSLEREKERAIRAFFGPIRIHAIVYGFFKIDKRGRVLDAVAVDNPPITIMTKGMWLDVPKVALDILESRRLNIAAAIHAAEHAILSLLPSFVISSPGDVRTECKVAKKELGKDLQKVVRRGGGVGDQDNIPVLKPPHRQRPARLTFYDAKGGSCGSGIARKAFEFIDSLLKRAVARIEACACVTPKGCLECVCDERCKEMNSVMSKAGAGVVLRCLLGWEVDVEALPWGEIDQDDGGEMGELAGGLETVVLAREVPYRGSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>C8V3P3</accession>
    <name>C8V3P3_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_08271</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF74252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_681540.2">
        <property type="nucleotide sequence ID" value="XM_676448.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V3P3"/>
    <dbReference type="STRING" id="227321.C8V3P3"/>
    <dbReference type="GeneID" id="2869090"/>
    <dbReference type="KEGG" id="ani:ANIA_08271"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN8271"/>
    <dbReference type="eggNOG" id="ENOG502S7T4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015973_0_0_1"/>
    <dbReference type="InParanoid" id="C8V3P3"/>
    <dbReference type="OMA" id="EQDMAFT"/>
    <dbReference type="OrthoDB" id="5344169at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030643">
        <property type="term" value="P:intracellular phosphate ion homeostasis"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd11392">
        <property type="entry name" value="bHLH_ScPHO4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000099">
        <property type="entry name" value="Myc-family transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="2">
        <location>
            <begin position="569"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="661"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="338"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="399"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="441"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="507"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="695"/>
            <end position="707"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF74252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="707" mass="76436" checksum="CD655A94F5B60202" modified="2009-11-03" version="1">MEQDPSMSWSDMPPPGEDDFSNFLEFGFPDLEGQHGPTDHFPSRSVAQAAAMATSTAPPQQQQVVCMNSDGVSDQSQSYNRMPGDFPVELPGQGQQGMLHNSSYSNGPMTPAFYAQKPQMFHSSQQQQPVQPQSSQPYNPQGQMMIPPTPNSIELHGNAAPYPQRVGDNSEMYDRYTRMMEEQALYTPLVSPAMTPLESQFRQPEYTIPGEYFSPLSSPAIEAQHPNPNGFPIHSGPLTEVNFVHSPVDNAFPLSSAPPSPGLARKYKRRSSAASKTFQSRAKKQQSPSVRPLARTRSRLTDEVMTTLSEGQINPTPNPPQNGSRSHFGSAESSGQDSVSPEPLSEPLMPPPALPPSRKSPAIAPQARQQQNPSEPATPAMLMRMQRSPLARSAPDHNLTPTQRPMNQVQDEVMEDVILPEAANPSAQLFRPQVARIDTAMPTSTSSQGVSLNATAHSAPHQVSLSEKPPASIAPSPRTAAMPSPSGPVPKKSDTPKLGPVSRKRQSLSSSHPSPSLRPKISPNIQPLVAGDTSAAYLAGIKSNYQQILEGTLLPGVSYPETLAENLSSKRTNHKLAEQGRRNRINTALKEIETLIPAAYVQMRLHKEAATCNGKGEKEKERTGNQPISKASTVEMAIDYIKSLKAELDATKVKLAAAEAKLGTSETAKEAHGSNGQQNEEKAVDEINTTDRTSDPNNAQSSTAGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>C8V3R0</accession>
    <name>C8V3R0_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein PXR1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">PinX1-related protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Protein pxr1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">ANIA_11066</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in rRNA-processing at A0, A1 and A2 sites and negatively regulates telomerase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PINX1 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF74283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467302.1">
        <property type="nucleotide sequence ID" value="XM_050611256.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V3R0"/>
    <dbReference type="STRING" id="227321.C8V3R0"/>
    <dbReference type="GeneID" id="74896761"/>
    <dbReference type="KEGG" id="ani:ANIA_11066"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN11066"/>
    <dbReference type="eggNOG" id="KOG2809">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052839_0_0_1"/>
    <dbReference type="InParanoid" id="C8V3R0"/>
    <dbReference type="OMA" id="PCWDQSS"/>
    <dbReference type="OrthoDB" id="29523at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050656">
        <property type="entry name" value="PINX1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23149">
        <property type="entry name" value="G PATCH DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23149:SF31">
        <property type="entry name" value="PROTEIN PXR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="G-patch" evidence="11">
        <location>
            <begin position="25"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="172"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="172"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="217"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="235"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00043878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CBF74283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="310" mass="34817" checksum="982B3AE258F4EDAA" modified="2009-11-03" version="1">MGLAAPRKKTKISHDPNNTNWSRSTSGFGHKILSSQGWTPGSFLGARNAAHADMFTAASASHIRVIVKDDTLGLGARSKRDLLDEPTGLDAFKGLLGRLNGKTDVELQADQRKRDDVKLARYAATKWQAVRFISGGLLAQEKDESKETAECTLKSGAKNANPVDNNCADDKTCATDLSQDSKSKNRRAKDDEKSEKEKERKDGKDKKDKKDKKDKKDKKDKMDKKDKKDKKDKKDKKDTNDKKDTNDKNDKKRKRAEQQEDSDNPVPGPSHAVKEHRPPGRHMIRGRHIAQKRKALMDDKSLNEIFMVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>C8V4S4</accession>
    <name>C8V4S4_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ANIA_11400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF75944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467538.1">
        <property type="nucleotide sequence ID" value="XM_050611515.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V4S4"/>
    <dbReference type="GeneID" id="74896993"/>
    <dbReference type="KEGG" id="ani:ANIA_11400"/>
    <dbReference type="HOGENOM" id="CLU_2573868_0_0_1"/>
    <dbReference type="InParanoid" id="C8V4S4"/>
    <dbReference type="OrthoDB" id="4494726at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF75944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="81" mass="9057" checksum="34802C906D60400E" modified="2009-11-03" version="1">MNGILQLIDQAQSPSLILGKNTDLQKKIITLCCVFTTEDTTEGYYTIFKKVYNIMHKLTGKKLTFYAIHGTGLHAIGYLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>C8V680</accession>
    <name>C8V680_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Actin-related protein 2/3 complex subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ANIA_08065</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the Arp2/3 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
            <location evidence="1 6">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ARPC3 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF73813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467248.1">
        <property type="nucleotide sequence ID" value="XM_050611198.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V680"/>
    <dbReference type="FunCoup" id="C8V680">
        <property type="interactions" value="980"/>
    </dbReference>
    <dbReference type="STRING" id="227321.C8V680"/>
    <dbReference type="GeneID" id="2869083"/>
    <dbReference type="KEGG" id="ani:ANIA_08065"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN8065"/>
    <dbReference type="eggNOG" id="KOG3155">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094365_1_0_1"/>
    <dbReference type="InParanoid" id="C8V680"/>
    <dbReference type="OMA" id="TPSKWWL"/>
    <dbReference type="OrthoDB" id="200404at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044396">
        <property type="term" value="P:actin cortical patch organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051654">
        <property type="term" value="P:establishment of mitochondrion localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007163">
        <property type="term" value="P:establishment or maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1760.10:FF:000002">
        <property type="entry name" value="Actin-related protein 2/3 complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1760.10">
        <property type="entry name" value="Actin-related protein 2/3 complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007204">
        <property type="entry name" value="ARPC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036753">
        <property type="entry name" value="ARPC3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12391">
        <property type="entry name" value="ARP2/3 COMPLEX 21 KD SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04062">
        <property type="entry name" value="P21-Arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016315">
        <property type="entry name" value="ARP2/3_P21-Arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69060">
        <property type="entry name" value="Arp2/3 complex 21 kDa subunit ARPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR016315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBF73813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="188" mass="21160" checksum="476C364692398D21" modified="2009-11-03" version="1">MPAYHSIFLEDRDVPVIGNFPVLPLRTRTRGPAYTLPMLPPGVADIDVQPDNESYDCVDEILSLFRANVLFRNFEINGPADRMLIYGTLFITECLGKVKPTMSAREAEKALTNVALDNFAIPGDASFPLNQAFEPPRDRQDAETLRSYLTQVRQEIASRLLARLYPGGVGPSKFWLSFTKRKFMGKSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>C8V6N8</accession>
    <name>C8V6N8_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glucokinase regulator family protein, putative (AFU_orthologue AFUA_1G17490)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ANIA_11038</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF73938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467261.1">
        <property type="nucleotide sequence ID" value="XM_050611212.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V6N8"/>
    <dbReference type="STRING" id="227321.C8V6N8"/>
    <dbReference type="GeneID" id="2869080"/>
    <dbReference type="KEGG" id="ani:ANIA_11038"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN11038"/>
    <dbReference type="eggNOG" id="ENOG502QS2J">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049049_1_0_1"/>
    <dbReference type="InParanoid" id="C8V6N8"/>
    <dbReference type="OMA" id="CPPTFCT"/>
    <dbReference type="OrthoDB" id="311172at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016835">
        <property type="term" value="F:carbon-oxygen lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070095">
        <property type="term" value="F:fructose-6-phosphate binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141089">
        <property type="term" value="F:glucose sensor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019210">
        <property type="term" value="F:kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046348">
        <property type="term" value="P:amino sugar catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001678">
        <property type="term" value="P:intracellular glucose homeostasis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034504">
        <property type="term" value="P:protein localization to nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd05007">
        <property type="entry name" value="SIS_Etherase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10490:FF:000014">
        <property type="entry name" value="N-acetylmuramic acid 6-phosphate etherase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00068">
        <property type="entry name" value="MurQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005488">
        <property type="entry name" value="Etherase_MurQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005486">
        <property type="entry name" value="Glucokinase_regulatory_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040190">
        <property type="entry name" value="MURQ/GCKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00274">
        <property type="entry name" value="N-acetylmuramic acid 6-phosphate etherase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003915">
        <property type="entry name" value="PRK05441.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009222">
        <property type="entry name" value="PRK12570.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10088">
        <property type="entry name" value="GLUCOKINASE REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10088:SF4">
        <property type="entry name" value="GLUCOKINASE REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22645">
        <property type="entry name" value="GKRP_SIS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SIS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01272">
        <property type="entry name" value="GCKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SIS" evidence="3">
        <location>
            <begin position="58"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBF73938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="373" mass="38874" checksum="8DEFF3CA9827D6E0" modified="2009-11-03" version="1">MDLDNLSRLQTEAVNPQTSLIDKLSTLQMCTVINQEDRRVAASVTPCLPRIAAAIDALAPRVRRGGRVVYVGAGTSGRLGILDASEIPPTFAAPPEQFIGLIAGGDAAIRRAQEGAEDSLALAEADMAALELRPELDSVVGIAASGRTPYVLGCIGFAKRKGCITIGVVCVEPSALGESGEVDFLIAPLPGPEVVSGSTRLKAGTATKLVLNMLSTGTMIRVGKTYGNTMVDLVASNAKLRQRSRNILRRLSAECASMPNLELDSLLSRCKGSVKLALLMVATGKPVEECREVLEAADQQLAKALELAATSTLQQGAEGRLRDQSTELILCIDGGGSKCAAVVATKAGAVLGRGEAGPCNMCVPLLLLSRKDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>C8V8R9</accession>
    <name>C8V8R9_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Acyl-CoA thioester hydrolase, putative (AFU_orthologue AFUA_4G07060)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ANIA_10552</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acyl coenzyme A hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF77559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467729.1">
        <property type="nucleotide sequence ID" value="XM_050611736.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V8R9"/>
    <dbReference type="STRING" id="227321.C8V8R9"/>
    <dbReference type="GeneID" id="2872218"/>
    <dbReference type="KEGG" id="ani:ANIA_10552"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN10552"/>
    <dbReference type="eggNOG" id="KOG2763">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032862_1_0_1"/>
    <dbReference type="InParanoid" id="C8V8R9"/>
    <dbReference type="OMA" id="QFNYTFL"/>
    <dbReference type="OrthoDB" id="331699at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006637">
        <property type="term" value="P:acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd03442">
        <property type="entry name" value="BFIT_BACH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.10:FF:000032">
        <property type="entry name" value="Acyl-CoA thioester hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.10:FF:000038">
        <property type="entry name" value="Acyl-CoA thioester hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033120">
        <property type="entry name" value="HOTDOG_ACOT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12655">
        <property type="entry name" value="ACYL-COA THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12655:SF0">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51770">
        <property type="entry name" value="HOTDOG_ACOT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="HotDog ACOT-type" evidence="6">
        <location>
            <begin position="101"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="HotDog ACOT-type" evidence="6">
        <location>
            <begin position="296"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="81"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBF77559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="463" mass="51806" checksum="986C39EAB13F69E8" modified="2009-11-03" version="1">MFSLSTRRSVASHSKYLCAATTGANVRSPAVNSLYYASTREFQSTPSQAAFRPTWMPMRVKTPWIEALNKSREQPQSGQEEAPRAKPDLTPKRMADSYYSAILPLAQDKWLLDTYLNASGHIRLGSLLMDLDALAGVIAYRHTGDSVTTVTAAVDRITIEHPLMEICDLELSGQVTYATGRSSMEVSLQVAKVPAPGEKPNPEDVLITCAFTMVSLDPATKKPVNVAPLLVETEEERALFEKGEKNYQAKKALRKRSLLEKAPDAEESNLIHSLWTKEMSYLKSPEKRPANTISMSDAVLKSAMIMQPQDRNRHNFMIFGGFLLKQTFELAFCCAASFSHARPNFISLDPSTFENPVPVGSVLYLRATVAYTEPLERESGTKSKYTKIQVRVDTKVRDVEHGTKKATGMFNYTFLVEGDVHVMPKSYGEYMVWTDARRRARNTDELTPIRERSALRSLDSVTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>C8V9C8</accession>
    <name>C8V9C8_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">prephenate dehydratase</fullName>
            <ecNumber evidence="2">4.2.1.51</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ANIA_11135</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>prephenate + H(+) = 3-phenylpyruvate + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:21648"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:18005"/>
            <dbReference type="ChEBI" id="CHEBI:29934"/>
            <dbReference type="EC" id="4.2.1.51"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-phenylalanine biosynthesis; phenylpyruvate from prephenate: step 1/1.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.51" evidence="2"/>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF77876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467769.1">
        <property type="nucleotide sequence ID" value="XM_050611784.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V9C8"/>
    <dbReference type="FunCoup" id="C8V9C8">
        <property type="interactions" value="113"/>
    </dbReference>
    <dbReference type="STRING" id="227321.C8V9C8"/>
    <dbReference type="GeneID" id="74896803"/>
    <dbReference type="KEGG" id="ani:ANIA_11135"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN11135"/>
    <dbReference type="eggNOG" id="KOG2797">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035008_5_1_1"/>
    <dbReference type="InParanoid" id="C8V9C8"/>
    <dbReference type="OMA" id="PLMIYRE"/>
    <dbReference type="OrthoDB" id="983542at2759"/>
    <dbReference type="UniPathway" id="UPA00121">
        <property type="reaction ID" value="UER00345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004664">
        <property type="term" value="F:prephenate dehydratase activity"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009094">
        <property type="term" value="P:L-phenylalanine biosynthetic process"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="CDD" id="cd04905">
        <property type="entry name" value="ACT_CM-PDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13532">
        <property type="entry name" value="PBP2_PDT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000034">
        <property type="entry name" value="Chorismate mutase/prephenate dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000228">
        <property type="entry name" value="Chorismate mutase/prephenate dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008242">
        <property type="entry name" value="Chor_mutase/pphenate_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001086">
        <property type="entry name" value="Preph_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018528">
        <property type="entry name" value="Preph_deHydtase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008865">
        <property type="entry name" value="PRK11898.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21022">
        <property type="entry name" value="PREPHENATE DEHYDRATASE P PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21022:SF19">
        <property type="entry name" value="PREPHENATE DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00800">
        <property type="entry name" value="PDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001500">
        <property type="entry name" value="Chor_mut_pdt_Ppr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00857">
        <property type="entry name" value="PREPHENATE_DEHYDR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51171">
        <property type="entry name" value="PREPHENATE_DEHYDR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0584">Phenylalanine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prephenate dehydratase" evidence="8">
        <location>
            <begin position="5"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="ACT" evidence="9">
        <location>
            <begin position="225"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBF77876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="307" mass="34266" checksum="1D86C1CB86CD4146" modified="2009-11-03" version="1">MAPFKVTFLGPAASFSHQAAVETFGRSSELIPCLSFADAIAAVQRRDADYAIVPFENSTNGSVVQTLDLLVDRNGSYNDVKVCGEYYLTVHHCLLARKGFISAARRNYSSITKIYTHPQAWGQCEIFLAKYFKGVERQDVSSTSKASETVLKTTSEVNAAIASRFAGEYYGLDILEENIEDTANNTTRFLVLRNVYSTTTIQFQPELARELSKSPAVLETKKALFSFMVRQDTLGTLADALLIFKDRGLNLTSINTRPSHIQAWKYVFLVESETDQNQEVPDIMDSLRKVTENCKHLGTWANKLVST</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>C8VBH1</accession>
    <name>C8VBH1_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA exonuclease 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">ANIA_10955</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Exoribonuclease involved in ribosome biosynthesis. Involved in the processing of ITS1, the internal transcribed spacer localized between the 18S and 5.8S rRNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the REXO4 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF79489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467963.1">
        <property type="nucleotide sequence ID" value="XM_050611998.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VBH1"/>
    <dbReference type="FunCoup" id="C8VBH1">
        <property type="interactions" value="784"/>
    </dbReference>
    <dbReference type="STRING" id="227321.C8VBH1"/>
    <dbReference type="GeneID" id="74896697"/>
    <dbReference type="KEGG" id="ani:ANIA_10955"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN10955"/>
    <dbReference type="eggNOG" id="KOG2249">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022453_2_1_1"/>
    <dbReference type="InParanoid" id="C8VBH1"/>
    <dbReference type="OMA" id="SQKEMRF"/>
    <dbReference type="OrthoDB" id="8191639at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06144">
        <property type="entry name" value="REX4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000007">
        <property type="entry name" value="Interferon-stimulated exonuclease gene 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037431">
        <property type="entry name" value="REX4_DEDDh_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047021">
        <property type="entry name" value="REXO1/3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801:SF45">
        <property type="entry name" value="RNA EXONUCLEASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801">
        <property type="entry name" value="RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exonuclease" evidence="11">
        <location>
            <begin position="103"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="267"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="277"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="288"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CBF79489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="299" mass="33753" checksum="872423998BF2962F" modified="2009-11-03" version="1">MELKALSSNWKKLQETLKKDVSTPPTQKRKRSDREPQNDLVKKRKSAAEAGKRNSTSRTVQAPKKQKRMSQGTPDKNASANETSNAVVSRENEGRSPNVEIGKYIAMDCEMVGIGPDPDNDSALARVSIVNYNGDQVYDSYVRPKEMVTDWRTHVSGILPKHMAEARSLEQVQKEVAEILEGRILVGHALRNDLDALLLSHPKRDIRDTSKHPPYRKVAGGGSPRLKILASEFLGLNIQAGAHSSMEDAKATMLLYRRDKDEFEREHLKKWPVRALPESKENGGDEKKKKKKKKKTRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>C8VBR9</accession>
    <name>C8VBR9_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Choline transport protein, putative (AFU_orthologue AFUA_2G15150)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ANIA_10972</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF79670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="XP_050467985.1">
        <property type="nucleotide sequence ID" value="XM_050612024.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VBR9"/>
    <dbReference type="GeneID" id="74896709"/>
    <dbReference type="KEGG" id="ani:ANIA_10972"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN10972"/>
    <dbReference type="eggNOG" id="KOG1289">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004495_2_4_1"/>
    <dbReference type="InParanoid" id="C8VBR9"/>
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    <dbReference type="OrthoDB" id="4476201at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015185">
        <property type="term" value="F:gamma-aminobutyric acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0015812">
        <property type="term" value="P:gamma-aminobutyric acid transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF24">
        <property type="entry name" value="TRANSPORT PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G15150)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="47"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="280"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="329"/>
            <end position="349"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="379"/>
            <end position="401"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="407"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="450"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="482"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBF79670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="516" mass="56199" checksum="197AEFC1F337CA21" modified="2009-11-03" version="1">MDTVQETKSSASKADYGATSIPDVELVKGEVGIADQLEMPMKRKFNILSIIAVGYNISNSWVAIAASFAIAIQSGGALSLLYGIIVVTFAMLCTGVTLAELASVYPTAGGQYHFTSILASRRWSRGLSYFSGLAAIFSWICLGASIGLSGTNALMAIIIRWQPAYQPASWHYFLVYQLFNILVVVYNMYLANKTLWIYNIGFVLSISTFIVITVACPARSEVHVDSKEIWAIMTNGSGWSDGISFLTGLSTPQFMLSGIDATLHLAEECLDPERVVPKAVLATVIVGFLTAFPFAIAISYSYRDVAESLSTNTGFPIFFIWEKATHSPAAATVFMACLFVISCVAFNAVHQTASRLTWSFARDDALFFSKKLSPVHHSLGVPVNALVLDGILVFLVGIVYICSSTAFNSFISTTVIVAQVSFAIPALLVILRRRSSHFLPESRPFRVPNVVGYICNVVCIIWAVILTVFFCFPAALPVTGGNMNYASVVLVVMLIIGVANWFAYARGHYRGPRLEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C8VCY9</accession>
    <name>C8VCY9_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_10915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF78818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467873.1">
        <property type="nucleotide sequence ID" value="XM_050611900.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VCY9"/>
    <dbReference type="STRING" id="227321.C8VCY9"/>
    <dbReference type="GeneID" id="74896675"/>
    <dbReference type="KEGG" id="ani:ANIA_10915"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN10915"/>
    <dbReference type="eggNOG" id="KOG2084">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070656_0_0_1"/>
    <dbReference type="InParanoid" id="C8VCY9"/>
    <dbReference type="OMA" id="PGEECCI"/>
    <dbReference type="OrthoDB" id="1028014at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050869">
        <property type="entry name" value="H3K4_H4K5_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197:SF292">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="1">
        <location>
            <begin position="7"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF78818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="341" mass="38421" checksum="13541F4592B75893" modified="2009-11-03" version="1">MLPWVHPHLAQSVNPDKGRQLQAAQSIQRGEVLLIDPPYAIIPISDVDATTSLRKAICSNPQCNKPVSRDTASRCPNRCNNDVFWCNDSCEETDKARHDFECTWLAKYTTSLLSKWGEYNFGMLWLIVRILSRRYTESSYPHNIEDKPPAHDSHPSLSRFKFGWPAIDSLCGTPETWSHAQVREWTVLVKKYLGSSTLPHDLSNSDVLALICKEEANSFGLYPRETGVFPPPNPPVSRGEQFAAAVYPRASIANHSCCPNIIHKPDKVGRMVFTAGRDIAAGEECCISYFDMTQYVSLQDRRRHLQGLFRFKCGCPRCLEEETAAADTANETHWDAFPGFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>C8VE17</accession>
    <name>C8VE17_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ANIA_11074</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF80312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468066.1">
        <property type="nucleotide sequence ID" value="XM_050612112.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VE17"/>
    <dbReference type="GeneID" id="74896767"/>
    <dbReference type="KEGG" id="ani:ANIA_11074"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN11074"/>
    <dbReference type="eggNOG" id="KOG1121">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085460_0_0_1"/>
    <dbReference type="InParanoid" id="C8VE17"/>
    <dbReference type="OMA" id="CVENHIA"/>
    <dbReference type="OrthoDB" id="4505704at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47501:SF5">
        <property type="entry name" value="HAT C-TERMINAL DIMERISATION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47501">
        <property type="entry name" value="TRANSPOSASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF80312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="267" mass="30260" checksum="41C7670C138ABF97" modified="2009-11-03" version="1">MQQHLEKHSIFAPYSQAKASVRSGQPSIMSFITKQESLSHQEHLEKNILCWIIRDKQAFITIKLPEFQQIFQDTPGIILPFSSQATLRRRLIDNFEIQRLQLKEELKITCKSIALSLDIWTSQNHLPILGIIGHWLMEDFIYQEKVLEFTELHGVYSRENLAAAVQLTLSELDLEEKLIIITGDNASNNKTMASELYYTLKGNIGESSILQFQGLDSYIRCLAYILNLVVKDILRALKSGSSEEAYAACISLCNGQPISTQSALAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>C8VEE9</accession>
    <name>C8VEE9_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ANIA_11079</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF80556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468095.1">
        <property type="nucleotide sequence ID" value="XM_050612143.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VEE9"/>
    <dbReference type="GeneID" id="2868650"/>
    <dbReference type="KEGG" id="ani:ANIA_11079"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN11079"/>
    <dbReference type="eggNOG" id="ENOG502SPFX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1277598_0_0_1"/>
    <dbReference type="InParanoid" id="C8VEE9"/>
    <dbReference type="OMA" id="DADHGHT"/>
    <dbReference type="OrthoDB" id="10058185at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF146">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="32"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="5"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="159"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBF80556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="216" mass="23191" checksum="6149A360FD63B0F0" modified="2009-11-03" version="1">MYTFCIGMAIGSVVNCAGLEDTDDAYCRFIAGPMVIIVSVINVVTDVYVLILPVPRLLKLQVTRRRKIGLLLVFASGLGACAAGLARLINASIHYHNTDTFWVQGRNAEFSIVEMNVAIIVACATSLPTFFTQVRSLGGSIYDSAVSLLHISRESASKRTSGSLTEESGRSSAGGSRNENARLHNLERLKGATTGHWGINGRGDSQELELLSTNSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C8VF14</accession>
    <name>C8VF14_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sreptomyces cyclase/dehydrase family protein (AFU_orthologue AFUA_6G07220)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ANIA_10642</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Interacts with coenzyme Q.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the COQ10 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF80957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468148.1">
        <property type="nucleotide sequence ID" value="XM_050612203.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VF14"/>
    <dbReference type="FunCoup" id="C8VF14">
        <property type="interactions" value="124"/>
    </dbReference>
    <dbReference type="STRING" id="227321.C8VF14"/>
    <dbReference type="GeneID" id="74896519"/>
    <dbReference type="KEGG" id="ani:ANIA_10642"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN10642"/>
    <dbReference type="eggNOG" id="KOG3177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079653_1_0_1"/>
    <dbReference type="InParanoid" id="C8VF14"/>
    <dbReference type="OMA" id="QLHAAMM"/>
    <dbReference type="OrthoDB" id="292693at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048039">
        <property type="term" value="F:ubiquinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045333">
        <property type="term" value="P:cellular respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07813">
        <property type="entry name" value="COQ10p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.530.20:FF:000048">
        <property type="entry name" value="Sreptomyces cyclase/dehydrase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044996">
        <property type="entry name" value="COQ10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005031">
        <property type="entry name" value="COQ10_START"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12901:SF10">
        <property type="entry name" value="COENZYME Q-BINDING PROTEIN COQ10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12901">
        <property type="entry name" value="SPERM PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03364">
        <property type="entry name" value="Polyketide_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Coenzyme Q-binding protein COQ10 START" evidence="4">
        <location>
            <begin position="94"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBF80957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="239" mass="27134" checksum="A9E55EFEA8A112E4" modified="2009-11-03" version="1">MNHLLAPRSIFYLNSKVPTIRPEILRCRLFCYTSRLQGLPQQPSYRQSYNPQFQSRIEKRTFLSSFIPSPPQASNNGDGNGNNKARILTASRTLPYPPSPLFNVISSVESYAEFLPFLTASTVTARDPETRYPTQAYLTVGYGPLSETFTSKVDCNRESWVVEARSGERFGIFEYLSTRWELVPETASEGGDARTTVNLEIRFEFKSQLYASMMSAVEGQMAGIMIEAFEKRIREVHGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>C8VIF3</accession>
    <name>C8VIF3_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase, short chain dehydrogenase/reductase family superfamily (AFU_orthologue AFUA_3G13450)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_03161</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF83284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468445.1">
        <property type="nucleotide sequence ID" value="XM_050612534.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VIF3"/>
    <dbReference type="GeneID" id="2873857"/>
    <dbReference type="KEGG" id="ani:ANIA_03161"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN3161"/>
    <dbReference type="eggNOG" id="KOG1611">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_9_1_1"/>
    <dbReference type="InParanoid" id="C8VIF3"/>
    <dbReference type="OMA" id="RMYTTSS"/>
    <dbReference type="OrthoDB" id="5296at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052184">
        <property type="entry name" value="SDR_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45458:SF2">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY SUPERFAMILY (AFU_ORTHOLOGUE AFUA_3G13450)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45458">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE SDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF83284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="257" mass="27496" checksum="83DCF5A024FD2C6A" modified="2009-11-03" version="1">MSRNILIVGATRGLGASLRNLYATEPSTRVFATTRSDNAPESYSHPHVSWLPNIDLTKPDVGERLVSQLPSSTKLAAVIITAGYFGLETFDTPDWDKQIQMYTTSAIAPVFVVQKLVKCGILGKGSKVILVSSESGSITLRHEKEGGGNYGHHASKAALNMVGKLLSLDLKPNGIAVGLVHPGFMRTEMTKGVGYDKYWDAGGAVTPDEAARSLAGFVDKFDISKTGEYWAPRGPGDIGTAEPVLGSDLPTPLQLPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>C8VK40</accession>
    <name>C8VK40_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ANIA_11186</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF82433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468326.1">
        <property type="nucleotide sequence ID" value="XM_050612400.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VK40"/>
    <dbReference type="GeneID" id="74896832"/>
    <dbReference type="KEGG" id="ani:ANIA_11186"/>
    <dbReference type="HOGENOM" id="CLU_2469067_0_0_1"/>
    <dbReference type="InParanoid" id="C8VK40"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF82433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="88" mass="9809" checksum="4AB8C36231202DCE" modified="2009-11-03" version="1">MSPATSFPAVSCILNPIEMKNRLATAAPNLSFRVPSSSSPLISASIHSVTFAIADPSSGEWYIVPLQVHYRQWATWPYVQVFYWPVIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>C8VKB6</accession>
    <name>C8VKB6_EMENI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_02702</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF84183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468563.1">
        <property type="nucleotide sequence ID" value="XM_050612668.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VKB6"/>
    <dbReference type="GeneID" id="2874375"/>
    <dbReference type="KEGG" id="ani:ANIA_02702"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN2702"/>
    <dbReference type="HOGENOM" id="CLU_110786_0_0_1"/>
    <dbReference type="InParanoid" id="C8VKB6"/>
    <dbReference type="OMA" id="ACVASHE"/>
    <dbReference type="OrthoDB" id="4368092at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="42"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="90"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF84183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="172" mass="17102" checksum="178BBBAB55AC35CC" modified="2009-11-03" version="1">MLLFKNDKCEGEPAGMATESFAKEASVDLKGFQVVEYGSSETGSGNATTTKTTTDGDADGTVTLPTVSSTSTSTSTDDEDGDDNEDEDGTVTLPTVSATTTATTTDESSTAEPTTTTAMESGSDSETSSTEPTSTESAGAEEPTPTGASSRLAPISLAGLAAVVLGAVAGGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>C8VM16</accession>
    <name>C8VM16_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ANIA_11328</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
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        <lineage>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
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    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
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            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF86241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468818.1">
        <property type="nucleotide sequence ID" value="XM_050612971.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VM16"/>
    <dbReference type="GeneID" id="74896930"/>
    <dbReference type="KEGG" id="ani:ANIA_11328"/>
    <dbReference type="HOGENOM" id="CLU_3068658_0_0_1"/>
    <dbReference type="InParanoid" id="C8VM16"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF86241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="53" mass="6056" checksum="8F7772C94E08F0BF" modified="2009-11-03" version="1">MVQGRVTLLKLKGNLDNTLSGFWHSRSARLPLPGASLPIQSDWYFYQCLYLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>C8VN44</accession>
    <name>C8VN44_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA damage and replication checkpoint protein Rfx1, putative (AFU_orthologue AFUA_5G06120)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ANIA_02296</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF86555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468851.1">
        <property type="nucleotide sequence ID" value="XM_050613006.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VN44"/>
    <dbReference type="STRING" id="227321.C8VN44"/>
    <dbReference type="GeneID" id="2874794"/>
    <dbReference type="KEGG" id="ani:ANIA_02296"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN2296"/>
    <dbReference type="eggNOG" id="KOG3712">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011526_0_1_1"/>
    <dbReference type="InParanoid" id="C8VN44"/>
    <dbReference type="OMA" id="MIWLREN"/>
    <dbReference type="OrthoDB" id="10056949at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000119">
        <property type="entry name" value="DNA damage and replication checkpoint protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003150">
        <property type="entry name" value="DNA-bd_RFX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039779">
        <property type="entry name" value="RFX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057321">
        <property type="entry name" value="RFX1-4/6/8-like_BCD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12619">
        <property type="entry name" value="RFX TRANSCRIPTION FACTOR FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12619:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR RFX4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25340">
        <property type="entry name" value="BCD_RFX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02257">
        <property type="entry name" value="RFX_DNA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51526">
        <property type="entry name" value="RFX_DBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RFX-type winged-helix" evidence="3">
        <location>
            <begin position="243"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="319"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="756"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="322"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="778"/>
            <end position="787"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBF86555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="862" mass="95096" checksum="5BB8A284D8034BC2" modified="2009-11-03" version="1">MPPELARAASLSSSAASQSTQVVAPQSRPGTADLMRSRSETVISRNSRRPRSRGSTASIHSTTTQQTQDQQLTDGFPQFLPAQTSAGSNVFGNNPEDIIMRFGQQLSHQVNGTALDSLQDAHHSAISRADEFPNHAVHGHHLSHHSLPSGVSHGMPGVPIPQYQNIYDSGIENHIQEHVLDEHDASEAGLKKKKGSSSSLANDNELRKLLRQYEGYTLKQMAAEVLKHEGAGGKAEKVKQVFAMIWLKENCRKSTGSVRRDRVYCCYAEKCGTERVSVLNPASFGKLVRIIFPNVQTRRLGVRGESKYHYVDLTVIEEKQQKPSTSTTQNPSRDSTAVGGVDAMNGNDMQRAASTIQQPTADTALFPSPTTSFAPRASIDRAISGCGCQASSQAEVITLENVASHSGKLIYQMLQLPTTDSSSVDTDSLQLPDINYYLPENTDSKVAAALAALYRSHCISVIDSFRYCKERNLLRFFSAFHGTLTVPVQKLLTHPNLAPWIKECDWLMYQKMIAFVAPLTTQVVPKLVLDAFSSISQRLTTHIAETFKAQPVHVSLARLLPAHIFCNLLKHMLDVNQSANAAAAWLCHPDNRNQMWLDFTTLVDPKEMITRANIPVCAEQATEQILKDDIRALLTPVADLNPAASHPFFSQPDLEKSPKPHKFSVEESVGDEYNFPDKWISFILNLAHIFPQHRTQCIIERVDALWDCILHRLTLGGAQSFSAWWMTKVFFHEMMLWQAEKGGFMHYTPSTLQKAGLDSDQSGPGGLVLRNSPKVVGNESSTSNAQDGASLERSRMGVETNPSRMDDEKPTDISENLTSFHAPNHDDSAIDLDDDSMLMTVGKYGDMMVSDPADAEGDVIVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C8VNK3</accession>
    <name>C8VNK3_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cep57 centrosome microtubule-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ANIA_10225</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF85306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468702.1">
        <property type="nucleotide sequence ID" value="XM_050612830.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VNK3"/>
    <dbReference type="STRING" id="227321.C8VNK3"/>
    <dbReference type="GeneID" id="2875734"/>
    <dbReference type="KEGG" id="ani:ANIA_10225"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN10225"/>
    <dbReference type="eggNOG" id="ENOG502S3TV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004834_0_0_1"/>
    <dbReference type="InParanoid" id="C8VNK3"/>
    <dbReference type="OMA" id="MKSDQIY"/>
    <dbReference type="OrthoDB" id="76453at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
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    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051756">
        <property type="entry name" value="Centrosomal_MT-associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024957">
        <property type="entry name" value="Cep57_MT-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025925">
        <property type="entry name" value="PPC89_CLD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19336:SF9">
        <property type="entry name" value="SPINDLE POLE BODY PROTEIN PPC89"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19336">
        <property type="entry name" value="UNCHARACTERIZED DUF1167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14197">
        <property type="entry name" value="Cep57_CLD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06657">
        <property type="entry name" value="Cep57_MT_bd"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
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    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPC89 centrosome localisation" evidence="7">
        <location>
            <begin position="397"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="Cep57 centrosome microtubule-binding" evidence="6">
        <location>
            <begin position="844"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
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            <begin position="1"/>
            <end position="38"/>
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    <feature type="region of interest" description="Disordered" evidence="5">
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            <begin position="60"/>
            <end position="264"/>
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    <feature type="region of interest" description="Disordered" evidence="5">
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            <begin position="466"/>
            <end position="586"/>
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    <feature type="region of interest" description="Disordered" evidence="5">
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            <begin position="600"/>
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    <feature type="region of interest" description="Disordered" evidence="5">
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            <begin position="663"/>
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    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="947"/>
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    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="330"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="18"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="77"/>
            <end position="90"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
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            <begin position="109"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="132"/>
            <end position="143"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="144"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="179"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="203"/>
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            <begin position="227"/>
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            <begin position="625"/>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="969"/>
            <end position="978"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBF85306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="996" mass="111457" checksum="488CC0160531E8B0" modified="2009-11-03" version="1">MSRDNTANSFASFGSDFDPEHEAIASTREIDESPRLPKMKGAFSKLSQVDEEEEPDYVFNTSTFEQYLPNISPIGTSEEEEDHEIDDDISLEVGRAPTNPPRRLDDSRNSYLSMENSVRSSSPAVRLDVPTPQKSAMRSSNRRAVSESLRKDAQLRQATLAHKENIDPNPPSKSRKERRTLSEIHAKVRDSYDGSFLEDERPPAATTTTTRPTRFGNSNISHQIADAVERASQEAYAKEARRAKARASANAGGDTGTQQSFLLPDLPNLSDLVSGVYEDGMPVYTRQPRTRTTRFVSPPADVTDASFSREHMPLDTIPIPEDEKALFVSLRLLQDKVSELERAKADAEKKLEDIRQENNFLKGGKARQRERESHGKRYEVEQNDYKKDRLINENQKLESTNLALQNKVDLLERKSDIQEAALKKLSKERDMAVSQLGVAYLESQDLKSENEVLREEIAELKARFAQLLPGSKTRDNTAQSEQNTASDASAEADDSQVDTRRSTKDATAKSTRSRSKSRKEDTRTRVSSQVDREISRLERERADEELFSIELPRVRESSMSKKQKVNRPRSTSAQTKKQPNTGRRVKRVVVEEVELTGPVEFTTELTGHTKETTGRTKETTGYTKDSTGQTRKSSAAEQDLTLLSFIDEREIAQLRKTLEEERLARKRRQSNPVLEHGAGETDNLTRQSALKPAPRKSSLKETKVPVPRPASALGDLTSHSKPEATEGESQLTVPAERQRRHSDHSVTPLAQRRRPRIAEEMTSAFILPDITLRHADLAENLTKLPEATQQALNRATQHNGGNCTVCKQSIPGEGCEHTSDAVKIPKPVPVSERMPEPVSYNEEPTLRPAQTPAVALATVLKALEDELSHLRIQLVSCQGAYNKLDASISKRQRKALGEKIGKLLKDMDMKADQIYALYDVLEGQKQRGQEMTEQEMEVTLQSIGIEANPKQGEVTGTTERSSRKGGTDYDVDDDDSELPWEGIESTVEMTGGSRHN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2013-05-01" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C8VP82</accession>
    <accession>Q5BAG8</accession>
    <name>CAN1N_EMENI</name>
    <protein>
        <recommendedName>
            <fullName>Cullin-associated NEDD8-dissociated protein 1, N-terminal part</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Cullin-associated and neddylation-dissociated protein 1, N-terminal part</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">candA-N</name>
        <name type="ORF">AN2462</name>
    </gene>
    <organism>
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2011" name="Mol. Biol. Cell" volume="22" first="153" last="164">
            <title>Recruitment of the inhibitor Cand1 to the cullin substrate adaptor site mediates interaction to the neddylation site.</title>
            <authorList>
                <person name="Helmstaedt K."/>
                <person name="Schwier E.U."/>
                <person name="Christmann M."/>
                <person name="Nahlik K."/>
                <person name="Westermann M."/>
                <person name="Harting R."/>
                <person name="Grond S."/>
                <person name="Busch S."/>
                <person name="Braus G.H."/>
            </authorList>
            <dbReference type="PubMed" id="21119001"/>
            <dbReference type="DOI" id="10.1091/mbc.E10-08-0732"/>
        </citation>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>INTERACTION WITH CANDA-C; CULA AND CULD</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes that promotes the exchange of the substrate-recognition F-box subunit in SCF complexes, thereby playing a key role in the cellular repertoire of SCF complexes. Acts as a F-box protein exchange factor when interacting with candA-C.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Interacts with candA-C. Interacts with unneddylated cullins culA and culD; interaction occurs only when complexed with candA-C.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
        <text>Requires candA-C for nuclear localization.</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="2">Cells show a dark red color when grown on an air-medium interface that induces development. Cells are able to initiate the cycle but are blocked in the initial stage of early nest formation. Cells exhibit reduction in asexual development and block in sexual development.</text>
    </comment>
    <comment type="miscellaneous">
        <text>In E.nidulans, CAND1 is separated into 2 distinct proteins: candA-N and candA-C (AC Q5BAH2), corresponding to the N- and C-termini respectively of the protein in other species.</text>
    </comment>
    <comment type="sequence caution" evidence="3">
        <conflict type="erroneous gene model prediction">
            <sequence resource="EMBL-CDS" id="EAA64168" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EMBL" id="AACD01000040">
        <property type="protein sequence ID" value="EAA64168.1"/>
        <property type="status" value="ALT_SEQ"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF86906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VP82"/>
    <dbReference type="SMR" id="C8VP82"/>
    <dbReference type="STRING" id="227321.C8VP82"/>
    <dbReference type="EnsemblFungi" id="CBF86906">
        <property type="protein sequence ID" value="CBF86906"/>
        <property type="gene ID" value="ANIA_10306"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AN10306"/>
    <dbReference type="eggNOG" id="KOG1824">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_357759_0_0_1"/>
    <dbReference type="InParanoid" id="C8VP82"/>
    <dbReference type="OMA" id="MAIIQND"/>
    <dbReference type="OrthoDB" id="6260732at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010265">
        <property type="term" value="P:SCF complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043935">
        <property type="term" value="P:sexual sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000909">
        <property type="term" value="P:sporocarp development involved in sexual reproduction"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039852">
        <property type="entry name" value="CAND1/CAND2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12696">
        <property type="entry name" value="TIP120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="chain" id="PRO_0000422244" description="Cullin-associated NEDD8-dissociated protein 1, N-terminal part">
        <location>
            <begin position="1"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT 1">
        <location>
            <begin position="5"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT 2">
        <location>
            <begin position="50"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="21119001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="339" mass="36843" checksum="D448F2E0B453BAE1" modified="2009-11-03" version="1">MGDRHTIQQNLNGLLSKLNDPDPDMRYMSLNDLYGILSNPCSSYLAHDQASATRLAEGLLKALDDQHGDVQNQALKCLGPLVARLPLEGLRTLLERLSNLTTSQTIDTSVPNTALRVIVTALPRPQPNQAPSPDANMAYSAVSEVLIPRLIGPGPHKRRGSVTKGMLEKDPAKGFSSDAIDVLIQVASCFGALLQESELTALEKAVMSIIDNDTAGTVVTKRALAAISALVVYFSDEQFGILVSELVERFNSPQLSTVHRRHLIAAVGCLARTVPAKFGPHLSTLAPFIFSAVGEDNLEVSHVLHYLCTSASNVYSSRNKPKIYHQYRQLPKEKLITGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>C8VQ73</accession>
    <name>C8VQ73_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Histidine acid phosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ANIA_10039</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF90111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050469319.1">
        <property type="nucleotide sequence ID" value="XM_050611051.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VQ73"/>
    <dbReference type="STRING" id="227321.C8VQ73"/>
    <dbReference type="GeneID" id="74896165"/>
    <dbReference type="KEGG" id="ani:ANIA_10039"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN10039"/>
    <dbReference type="eggNOG" id="ENOG502SM2K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023111_0_1_1"/>
    <dbReference type="InParanoid" id="C8VQ73"/>
    <dbReference type="OMA" id="STQEWCL"/>
    <dbReference type="OrthoDB" id="258392at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF127">
        <property type="entry name" value="HISTIDINE ACID PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002992260" description="Histidine acid phosphatase" evidence="4">
        <location>
            <begin position="19"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="449"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="515"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="520"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="558"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBF90111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="570" mass="61845" checksum="66F449E09FDE1EF4" modified="2009-11-03" version="1">MMVGLSFALLSLLGVVAAAASGQTARVWAVYAYTINGETIPRVFPRSRALTPYGAYQLHEAGSAFRGRYVSVKAGADRPDARIENLSPYLVDNDDIKITSTPDVAVLASAQAFMQGVYPPLNESFNTTFFDNQLELADGSLISPPLGGYQYPSIVTVGAEDPQSLMVSGQALCSRHAAANLEYIASKEFWRTYEESAVFYNRLHTLSLSGHFDTKASSYANATAIAEFLDYQVVHNESLLHSLSAEDIKRARWYAGRYVFATNGNTSASGTTVDGGIRTIAGQGLASSVLNAFETTIQNRGANGKMTLQFGNYQTAVSFTSLLQLATTSPNFTSSLPRPGSSLVLELFSLESERYPTYPDPAQLYVRFLLHNGTRAEFVPYPLFGHGPSNTAIPFSEFQAEMQRMALGSTEDWCRRCNSSAVFCSGVVKPLPRQSAASKARKDRGGISAAVAGVIGSVVTIAVLALIGVVGFFLCLRTKRLRNPGLGGFKRDSKMASDSDLTFKNPQWGDAIKAPTASAKGHERHGSWEMKNKCPPRLVEQTVGPSSLADELEEEWDLHDTAPVRPREHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C8VRS0</accession>
    <name>C8VRS0_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydantoin racemase (Dcg1), putative (AFU_orthologue AFUA_1G13380)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_10110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HyuE racemase family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF89009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050469169.1">
        <property type="nucleotide sequence ID" value="XM_050613345.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VRS0"/>
    <dbReference type="FunCoup" id="C8VRS0">
        <property type="interactions" value="37"/>
    </dbReference>
    <dbReference type="STRING" id="227321.C8VRS0"/>
    <dbReference type="GeneID" id="74896210"/>
    <dbReference type="KEGG" id="ani:ANIA_10110"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN10110"/>
    <dbReference type="eggNOG" id="ENOG502RZNN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053002_1_1_1"/>
    <dbReference type="InParanoid" id="C8VRS0"/>
    <dbReference type="OMA" id="CAGMSGM"/>
    <dbReference type="OrthoDB" id="412018at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047661">
        <property type="term" value="F:amino-acid racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12500:FF:000003">
        <property type="entry name" value="Hydantoin racemase (Dcg1), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015942">
        <property type="entry name" value="Asp/Glu/hydantoin_racemase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052186">
        <property type="entry name" value="Hydantoin_racemase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053714">
        <property type="entry name" value="Iso_Racemase_Enz_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28047">
        <property type="entry name" value="PROTEIN DCG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28047:SF5">
        <property type="entry name" value="PROTEIN DCG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01177">
        <property type="entry name" value="Asp_Glu_race"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF89009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="295" mass="31454" checksum="19BD5138ACC94D86" modified="2009-11-03" version="1">MASISRPRFSILVINPNTSTHMTSALVPILDNLGYTDIHFDYFTAPQSETVTLPDGRVIHGIPSINSGEDSVVSALHCRPFVEPLVEKYDGFLVACYSAHPLVGMLREAIEKLEDAALLELGPTANTKKKFVTGIFEGSIVTSLSLVSSFQLTWDGGFGKSQAKDTFGIVTTGSSWKVELSNAVSDMLVNSGNHKGSSSRFAGVETTGLTAVELHTTPPEEVRRRIIEATERLIKANSRPVSAICLGCAGMAGMEEAVREGCIKAYGRKQGSRVKIVDGVVSGAGMLVTACKAGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>C8VSY9</accession>
    <name>C8VSY9_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">CTP synthase</fullName>
            <ecNumber evidence="3 12">6.3.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">UTP--ammonia ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">ANIA_00490</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="16">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 12">Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 12">
            <text>UTP + L-glutamine + ATP + H2O = CTP + L-glutamate + ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:26426"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Pyrimidine metabolism; CTP biosynthesis via de novo pathway; CTP from UDP: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the CTP synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.2" evidence="3 12"/>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF89380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050469206.1">
        <property type="nucleotide sequence ID" value="XM_050613386.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VSY9"/>
    <dbReference type="FunCoup" id="C8VSY9">
        <property type="interactions" value="892"/>
    </dbReference>
    <dbReference type="STRING" id="227321.C8VSY9"/>
    <dbReference type="GeneID" id="2876267"/>
    <dbReference type="KEGG" id="ani:ANIA_00490"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN0490"/>
    <dbReference type="eggNOG" id="KOG2387">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011675_5_0_1"/>
    <dbReference type="InParanoid" id="C8VSY9"/>
    <dbReference type="OMA" id="EFNNAYR"/>
    <dbReference type="OrthoDB" id="1739076at2759"/>
    <dbReference type="UniPathway" id="UPA00159">
        <property type="reaction ID" value="UER00277"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097268">
        <property type="term" value="C:cytoophidium"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003883">
        <property type="term" value="F:CTP synthase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044210">
        <property type="term" value="P:'de novo' CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006241">
        <property type="term" value="P:CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019856">
        <property type="term" value="P:pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd03113">
        <property type="entry name" value="CTPS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01746">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000207">
        <property type="entry name" value="CTP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000005">
        <property type="entry name" value="CTP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004468">
        <property type="entry name" value="CTP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017456">
        <property type="entry name" value="CTP_synthase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033828">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003792">
        <property type="entry name" value="PRK05380.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00337">
        <property type="entry name" value="PyrG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11550">
        <property type="entry name" value="CTP SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11550:SF0">
        <property type="entry name" value="CTP SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06418">
        <property type="entry name" value="CTP_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 12" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="4 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 12" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CTP synthase N-terminal" evidence="14">
        <location>
            <begin position="2"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamine amidotransferase" evidence="13">
        <location>
            <begin position="315"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00054275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00070745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU810713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF06418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CBF89380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="583" mass="65169" checksum="406FE21B7C87EC8E" modified="2009-11-03" version="1">MKYVLVSGGVISGVGKGIIASSTGLLLKTAGLSVSSIKIDPYLNPDAGLMNPLEHGECFVLDDGGEADLDLGNYERYLGVTLGRDNNITTGKIYQHVIEKERRGDYLGKTVQIVPHLTNEIQNWVERVARVPIDESGREPDVCIIELGGTVGDIESAPFVEAMSQLQRRVGKANFLQIHVSYVPLIGSEQKTKPTQRAISDVRSGGLRPDLIACRCETPLEEMTIRKIAGTCQVERDQVVGVHNVPSTYQVPILLENQGFLNTIKDLLEIRNLHIEPKYVELGKSMWHKWHGLAMSQDHVFDTVSIVLVGKYTSLHDSYLSVTKALEHASMHCQKKLNLIWVESSHLEEDHQSINPAEYYKAWHAVSTADGILVPGGFGQRGTEGMVKCAEWARTKNVPFLGICLGLQVAVIEYARNVCGMTKADSAEFNEECEQPAIVYMPEIDKTKMGGTMRLGKRPTIFQEGTEWSKFRKLYGNKKEIWERHRHRYEVNPDLVEKLEAAGLSFIGKDETGKRMEVIELKDHRWYVGVQFHPEYLSRVITPSKSFLGFFAAAAGCLDEITETFQGAHDLSHLQVRPKIESI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>C8VTF8</accession>
    <name>C8VTF8_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Peroxisomal fatty acid ABC transporter, putative (Eurofung)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">ANIA_10078</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF89509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050469227.1">
        <property type="nucleotide sequence ID" value="XM_050613409.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VTF8"/>
    <dbReference type="FunCoup" id="C8VTF8">
        <property type="interactions" value="449"/>
    </dbReference>
    <dbReference type="STRING" id="227321.C8VTF8"/>
    <dbReference type="GeneID" id="74896191"/>
    <dbReference type="KEGG" id="ani:ANIA_10078"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN10078"/>
    <dbReference type="eggNOG" id="KOG0064">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007587_1_1_1"/>
    <dbReference type="InParanoid" id="C8VTF8"/>
    <dbReference type="OMA" id="IHDMYLD"/>
    <dbReference type="OrthoDB" id="422637at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042626">
        <property type="term" value="F:ATPase-coupled transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005324">
        <property type="term" value="F:long-chain fatty acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015910">
        <property type="term" value="P:long-chain fatty acid import into peroxisome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042760">
        <property type="term" value="P:very long-chain fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd03223">
        <property type="entry name" value="ABCD_peroxisomal_ALDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050835">
        <property type="entry name" value="ABC_transporter_sub-D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384:SF67">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY D MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384">
        <property type="entry name" value="ATP-BINDING CASSETTE, SUB-FAMILY D MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06472">
        <property type="entry name" value="ABC_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="176"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="531"/>
            <end position="768"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CBF89509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="820" mass="91942" checksum="1D298274137624CE" modified="2009-11-03" version="1">MAAQSTLRQKQDPLLTLYIYYTNLLRGKFRRSSKTAKILAIIALLLSIVGTGYGGYNWFRERANERARGKRLLRRNSGIRGKDGSRTIYVPYKDSLTSKVKIYPTKPTTFDAHRRLFLNPPASARTGDEDSLGRIPPPTTKPGLNLAFLHQFLSLGSIMVPRWNSKETGLLMSHGVFLLLRTYLSLLIARLDGEIVRDLVAGKGRAFTWGIVKWCGIGTLASYTNAMIKFLQSKVSIAFRTRLTRYIHDLYLTADNNYYKLMNLDGSIGQGPDQFITQDLTLFCSAAAALYSSMGKPLVDLFVFNYQLYRSLGPLALSGILTGYFSTAVVLRKLSPPFGKLKAVEGKKEGDFRGLHSRLLANAEEISFYGGADIERVFLARSFKDLQRWMEGIYSLKIRYNMLEDVILKYSWSAFGYLITSLPVFLPAWGGLGGAMELADTSEVSGRERGRMKEFITNKRLMLSLADAGGRMMYSIKDISELAGYTSRVYSLVSALHRVHANAYYPPHDAGSELYSLEDVQGTIHIGFDGVRFEQVPVVAPSLYPRGGDELLESLSFVVHSGDHLLISGPNGVGKSAIARIVAGLWPVYRGLVSRPRGFGLDGIMFLPQRPYLSVGTLRDQVIYPHTEIDMRDAGVSESALQKILDDAHLGYLPSREGGWDSRKEWKDVLSGGEKQRMAMARLFYHEPRYAFLDEGTSAVSSDVEGLLYEQAKERGITLITISTRASLKKYHTFNLTVGVGSEGEQWQFERIGTAKEKLGVEKELEEIRKRLSKVDEWKKRRQEIEDELQKVWVDHGELAPSSYEEDFKAAEDEVEVAGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>C8VUL6</accession>
    <name>C8VUL6_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Hypothetical serine protease (Eurofung)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">ANIA_10030</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF89903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_657842.2">
        <property type="nucleotide sequence ID" value="XM_652750.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VUL6"/>
    <dbReference type="SMR" id="C8VUL6"/>
    <dbReference type="FunCoup" id="C8VUL6">
        <property type="interactions" value="330"/>
    </dbReference>
    <dbReference type="STRING" id="227321.C8VUL6"/>
    <dbReference type="GeneID" id="2876016"/>
    <dbReference type="KEGG" id="ani:ANIA_10030"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN10030"/>
    <dbReference type="eggNOG" id="KOG1153">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011263_1_4_1"/>
    <dbReference type="InParanoid" id="C8VUL6"/>
    <dbReference type="OMA" id="RHPDVDY"/>
    <dbReference type="OrthoDB" id="206201at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019863">
        <property type="term" value="F:IgE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000425">
        <property type="term" value="P:pexophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007039">
        <property type="term" value="P:protein catabolic process in the vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd04077">
        <property type="entry name" value="Peptidases_S8_PCSK9_ProteinaseK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.80:FF:000006">
        <property type="entry name" value="Autophagic serine protease Alp2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000007">
        <property type="entry name" value="Subtilisin-like serine protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.80">
        <property type="entry name" value="Peptidase S8 propeptide/proteinase inhibitor I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034193">
        <property type="entry name" value="PCSK9_ProteinaseK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010259">
        <property type="entry name" value="S8pro/Inhibitor_I9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037045">
        <property type="entry name" value="S8pro/Inhibitor_I9_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF11">
        <property type="entry name" value="CEREVISIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05922">
        <property type="entry name" value="Inhibitor_I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 8 12" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0720">Serine protease</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002991719" evidence="9">
        <location>
            <begin position="17"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="Inhibitor I9" evidence="11">
        <location>
            <begin position="43"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="10">
        <location>
            <begin position="177"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="218"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CBF89903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="477" mass="50450" checksum="83B4A0AA60D45728" modified="2009-11-03" version="1">MKGIFGLSLLPLLVAASPVVVDSIHNGAAPILSSTNAKEVPDSYIVVFKKHVDPVAASVHHSWVQDIHGQKSGGRADLKKRFLGLEFGFGEEIYDGLKATFNIAGSLMGYSGHFHEDTIEEIRKHPDIEYIERNSEVHTLEDTDVEKNAPWGLARISHRDRLTFGTFNKYLYASEGGEGVDVYTIDTGINIEHEDFEGRAFWGKTIPNNDADEDGNGHGTHCSGTIAGKKYGVSKKANIYAVKVLRSSGSGTMADVVQGVEWAVESHLKKAKKGGNGFKGSVANMSLGGGKSKTLEDAVNAGVEAGVHFAVAAGNDNADACSYSPAAAEKAVTVGASTLADERAYFSNYGKCTDIFAPGLNILSTWIGSKSAVNTISGTSMASPHIAGLLAYFVSLQPSKDSAFAVDFTPEKLKKDIISIATEGVLTDIPADTPNLLAWNGGGSTNYSDIIAKGGYKSGSHVDSTPFKAGGILAQAM</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-06-21" modified="2025-06-18" version="121" xmlns="https://uniprot.org/uniprot">
    <accession>P79020</accession>
    <accession>C8V8Z2</accession>
    <accession>Q5B529</accession>
    <name>PALA_EMENI</name>
    <protein>
        <recommendedName>
            <fullName>pH-response regulator protein palA/RIM20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">palA</name>
        <name type="ORF">AN4351</name>
    </gene>
    <organism>
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1997" name="J. Bacteriol." volume="179" first="1832" last="1835">
            <title>Characterisation of the pH signal transduction pathway gene palA of Aspergillus nidulans and identification of possible homologues.</title>
            <authorList>
                <person name="Negrete-Urtasun S."/>
                <person name="Denison S.H."/>
                <person name="Arst H.N. Jr."/>
            </authorList>
            <dbReference type="PubMed" id="9045850"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="1986" name="Mol. Gen. Genet." volume="203" first="346" last="353">
            <title>Regulation of gene expression by pH of the growth medium in Aspergillus nidulans.</title>
            <authorList>
                <person name="Caddick M.X."/>
                <person name="Brownlee A.G."/>
                <person name="Arst H.N. Jr."/>
            </authorList>
            <dbReference type="PubMed" id="3016485"/>
            <dbReference type="DOI" id="10.1007/BF00333978"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2003" name="Mol. Cell. Biol." volume="23" first="1647" last="1655">
            <title>YPXL/I is a protein interaction motif recognized by Aspergillus PalA and its human homologue, AIP1/Alix.</title>
            <authorList>
                <person name="Vincent O."/>
                <person name="Rainbow L."/>
                <person name="Tilburn J."/>
                <person name="Arst H.N. Jr."/>
                <person name="Penalva M.A."/>
            </authorList>
            <dbReference type="PubMed" id="12588984"/>
            <dbReference type="DOI" id="10.1128/MCB.23.5.1647-1655.2003"/>
        </citation>
        <scope>INTERACTION WITH PACC AND VPS32</scope>
    </reference>
    <comment type="function">
        <text evidence="1 6">Required for the proteolytic cleavage of the transcription factor pacC in response to alkaline ambient pH. May act as a scaffold protein that recruits the calpain-like protease palB via vps32 to its substrate pacC.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Interacts with pacC by binding to its two YPX[LI] motifs.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the palA/RIM20 family.</text>
    </comment>
    <dbReference type="EMBL" id="Z83333">
        <property type="protein sequence ID" value="CAB05920.3"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AACD01000075">
        <property type="protein sequence ID" value="EAA60512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF77701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_661955.1">
        <property type="nucleotide sequence ID" value="XM_656863.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P79020"/>
    <dbReference type="SMR" id="P79020"/>
    <dbReference type="ELM" id="P79020"/>
    <dbReference type="FunCoup" id="P79020">
        <property type="interactions" value="1159"/>
    </dbReference>
    <dbReference type="STRING" id="227321.P79020"/>
    <dbReference type="EnsemblFungi" id="CBF77701">
        <property type="protein sequence ID" value="CBF77701"/>
        <property type="gene ID" value="ANIA_04351"/>
    </dbReference>
    <dbReference type="KEGG" id="ani:ANIA_04351"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN4351"/>
    <dbReference type="eggNOG" id="KOG2220">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007181_0_0_1"/>
    <dbReference type="InParanoid" id="P79020"/>
    <dbReference type="OMA" id="VSHAEEM"/>
    <dbReference type="OrthoDB" id="64867at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000815">
        <property type="term" value="C:ESCRT III complex"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071467">
        <property type="term" value="P:cellular response to pH"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042318">
        <property type="term" value="P:penicillin biosynthetic process"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900198">
        <property type="term" value="P:positive regulation of penicillin biosynthetic process"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900376">
        <property type="term" value="P:regulation of secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="CDD" id="cd09241">
        <property type="entry name" value="BRO1_ScRim20-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09236">
        <property type="entry name" value="V_AnPalA_UmRIM20_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.280:FF:000011">
        <property type="entry name" value="pH-response regulator protein palA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.560">
        <property type="entry name" value="alix/aip1 in complex with the ypdl late domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.50">
        <property type="entry name" value="alix/aip1 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.280">
        <property type="entry name" value="alix/aip1 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025304">
        <property type="entry name" value="ALIX_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004328">
        <property type="entry name" value="BRO1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038499">
        <property type="entry name" value="BRO1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23030">
        <property type="entry name" value="PCD6 INTERACTING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23030:SF39">
        <property type="entry name" value="PROGRAMMED CELL DEATH 6-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13949">
        <property type="entry name" value="ALIX_LYPXL_bnd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03097">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01041">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51180">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000218879" description="pH-response regulator protein palA/RIM20">
        <location>
            <begin position="1"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="domain" description="BRO1" evidence="3">
        <location>
            <begin position="4"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="763"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="256"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="772"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="796"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="829"/>
            <end position="839"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="12588984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="6">
        <source>
            <dbReference type="PubMed" id="3016485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="7"/>
    <sequence length="847" mass="94769" checksum="D5707F68A5AF826A" modified="2003-10-01" version="3">MASNILQIPFRRSHTVSLSTALTQYISTKYDQRPDMFADDLLIIDRLRNEAINVQEPHVSGISRLVTYAAQLKWLGGKFPVDVGVEFPWYPAFGFNTSRPVSQDNIRFELANVIFNLAALYSQLAFAVNRTTTDGLKQACNYFCQAAGILAHLRTDIVPDMRSAPPEDMDEMTLRSLEELLLAQAQECFWQKAVMDGLKDASIARLAGQVSDFYGDACDHAVKSNAISPEWIHHMTAKQHHFAAAAQYRQSLDCLEKRKYGEEVARLRDAVACVNEALKESRWINRTVLGDLQGLKNRVTEDLKRAEKDNDMIYLNPVPPKSELKLIDRACMVAAKAPSQVTDAISMLGEKGPLGQPLFSKLVPYAVHIAASIYSDRRDRLVNERIIGELENMTDKLRDLLSSLNLPGSLQALEKPLGLPPSLVAHAEEMRQQDGLNRLRKSLLDIAKVKSNDRAVYTEGVELLAAEKAEDDASRRKFGTDRWTREASEAAAPKLYTTAREIDGYFTSAQSSDNLVEQKLHDSEAVFRVLTGTNRDLEAFVPSSRRATIPPEVEREVSRLRSCISEVNRLESRRKRKAQAVKDKARADDISSALVREAARLEREFPMQAIQASQFEDLFESRLRDYDVDLDMVAQEMHDQDQIVAQVRDANRAFTRAHTGDASTKEREKALQELENGYLKYKEIISNIEVGRKFYNDLAKIVGRFRDDVKAFVHKRRMEASQLEQDISSVAAMASLNISPIRQPPQQTVVSAPVSVSAAASVPAPTHFNPVKPQPQPPSQAIPPQSQPQPQPQPLRTPLTAPQPTRSVPQVTPGMWSPEMGIRFGPGGTTAQQSQQTWDPSKGMKFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="102" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AQU4</accession>
    <accession>C8VR37</accession>
    <name>Q5AQU4_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ANIA_09336</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF87426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_682605.1">
        <property type="nucleotide sequence ID" value="XM_677513.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AQU4"/>
    <dbReference type="GeneID" id="2867863"/>
    <dbReference type="KEGG" id="ani:ANIA_09336"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_0_1_1"/>
    <dbReference type="InParanoid" id="Q5AQU4"/>
    <dbReference type="OMA" id="LGAKHWI"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:001177">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF21">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="178"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="288"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="324"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="354"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="378"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="442"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="54"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBF87426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="503" mass="55526" checksum="EB8F4C3416C208D2" modified="2005-04-26" version="1">MEIVTDVQEKPSLAEAEDAKKRVITEVSHYEALSEEEKALDRRVNLKLDFILLMILAIGFIRQLLGIDKTNVGFVATSTFIEDANLHPNDISNSLSLFSATYVPLQPISAMIGRYIGPKWWVCTLMIVWGSICIAHVGVNSTSTFLALRLLLGVGESGFTPTAYYYMSLFYPKFSLGFRMGLFSGMYSVAGAFAGLLAYGLLHLETSVQHGWQTVFLFEGALTVFVAILGFIVLPVSPGKAWFLTPKERAHAIKRMERDYAQAEEAAEGESKITVRDVLDVLKDWKKLLIVVFNILSVLPVTAFTTFLPLIVEGMGYAGVKATLMAVPPFIVGTAGLIAIVYSSDHLKERSLHTVFGMCLGLIGCVVMATSYNEKLRYGFAHVCLAGVFAGGPLVAVWLASNTPNKACRSVILGINGWSNLAGVIAGQLFKSKYAPGYKYPLVVTMVLIAVGVGGFLAMRGVYMWENRRRRAIVQTWEGEDFVEEQNRTDRRGDRKVTWVYAY</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2016-11-02" modified="2026-01-28" version="107" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AR47</accession>
    <accession>C8VJP6</accession>
    <name>ASQD_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">O-methyltransferase asqD</fullName>
            <ecNumber evidence="1">2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">4'-methoxyviridicatin/aspoquinolone biosynthesis cluster protein asqD</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Aspoquinolone biosynthesis protein D</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">asqD</name>
        <name type="ORF">AN9233</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2014" name="Angew. Chem. Int. Ed." volume="53" first="12880" last="12884">
            <title>Non-heme dioxygenase catalyzes atypical oxidations of 6,7-bicyclic systems to form the 6,6-quinolone core of viridicatin-type fungal alkaloids.</title>
            <authorList>
                <person name="Ishikawa N."/>
                <person name="Tanaka H."/>
                <person name="Koyama F."/>
                <person name="Noguchi H."/>
                <person name="Wang C.C."/>
                <person name="Hotta K."/>
                <person name="Watanabe K."/>
            </authorList>
            <dbReference type="PubMed" id="25251934"/>
            <dbReference type="DOI" id="10.1002/anie.201407920"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>PATHWAY</scope>
    </reference>
    <comment type="function">
        <text evidence="2 4">O-methyltransferase; part of the gene cluster that mediates the biosynthesis of the aspoquinolone mycotoxins (PubMed:25251934). The role of asqD within the aspoquinolone pathway has still to be determined (Probable). The first step of the pathway is catalyzed by the nonribosomal peptide synthetase asqK that condenses anthranilic acid and O-methyl-L-tyrosine to produce 4'-methoxycyclopeptin. 4'-methoxycyclopeptin is then converted to 4'-methoxydehydrocyclopeptin by the ketoglutarate-dependent dioxygenase asqJ. AsqJ also converts its first product 4'-methoxydehydrocyclopeptin to 4'-methoxycyclopenin. The following conversion of 4'-methoxycyclopenin into 4'-methoxyviridicatin is catalyzed by the cyclopenase asqI. 4'-methoxyviridicatin is the precursor of quinolone natural products, and is further converted to quinolinone B. The prenyltransferase asqH1 then catalyzes the canonical Friedel-Crafts alkylation of quinolinone B with dimethylallyl cation to yield dimethylallyl quinolone, which is subjected to FAD-dependent dehydrogenation by the FAD-linked oxidoreductase asqF to yield conjugated aryl diene. The delta(3') double bond then serves as the site of the second alkylation with DMAPP catalyzed by the prenyltransferase asqH2 to yield a carbenium ion intermediate, which can be attacked by H(2)O to yield a styrenyl quinolone containing a C3'-hydroxyprenyl chain. The FAD-dependent monooxygenase asqG performs epoxidation of the terminal C7'-C8' olefin. Finally, after dehydratation of the epoxide at C3 by asqC, the quinolone epoxide rearrangement protein asqO catalyzes an enzymatic 3-exo-tet cyclization to yield the cyclopropyl-THF ring system in aspoquinolone.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Alkaloid biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF82267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AACD01000170">
        <property type="protein sequence ID" value="EAA61524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_682502.1">
        <property type="nucleotide sequence ID" value="XM_677410.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AR47"/>
    <dbReference type="SMR" id="Q5AR47"/>
    <dbReference type="EnsemblFungi" id="CBF82267">
        <property type="protein sequence ID" value="CBF82267"/>
        <property type="gene ID" value="ANIA_09233"/>
    </dbReference>
    <dbReference type="KEGG" id="ani:ANIA_09233"/>
    <dbReference type="eggNOG" id="KOG3178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005533_5_0_1"/>
    <dbReference type="InParanoid" id="Q5AR47"/>
    <dbReference type="OMA" id="NTMGARK"/>
    <dbReference type="OrthoDB" id="1535081at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF1">
        <property type="entry name" value="HYPOTHETICAL O-METHYLTRANSFERASE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005739">
        <property type="entry name" value="O-mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000437632" description="O-methyltransferase asqD">
        <location>
            <begin position="1"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="294"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="25251934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="3">
        <source>
            <dbReference type="PubMed" id="25251934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <evidence type="ECO:0000305" key="5">
        <source>
            <dbReference type="PubMed" id="25251934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAA61524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000005890"/>
        </source>
    </evidence>
    <sequence length="387" mass="42903" checksum="33A9A1910519D985" modified="2005-04-26" version="1">MPVENEFPRELPNHSLISSKSQMTLQSIWLFRYPVSSIVCVQFPTDFPKPVLALSARIAIDLGLFTHIVQKCPITSRSLAAITGAEELLITRILRLLSTAHFAEETSTGTWAPTPITKTMAKEEIAAGYRFICHMVVPALQSAPGYFQHHGYSCPTDAKDGLVQHALQTKKTSFEYIMSDPHLLKDFNLFMGNGMGARKSWLDWYPVQSNILDGADADPDKALIVDVGGGKGHDLIAFHKRYPNAGRLVLEDLPAAFDDLGQYSMVIEKVPHDFLAEAQPVKGAKAYLCHHILHDWPDNYCVRILEGISSAMTPGYSKLLLHEGIVPEKGVCQFQAMSDIATMACNGGMERTREQWRTLLHMAGLQLIRFWNSPDEGGDGIIEAAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="133" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ARB0</accession>
    <accession>C8VK20</accession>
    <name>Q5ARB0_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ANIA_09170</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF82396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_682439.1">
        <property type="nucleotide sequence ID" value="XM_677347.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ARB0"/>
    <dbReference type="SMR" id="Q5ARB0"/>
    <dbReference type="FunCoup" id="Q5ARB0">
        <property type="interactions" value="749"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5ARB0"/>
    <dbReference type="GeneID" id="2867946"/>
    <dbReference type="KEGG" id="ani:ANIA_09170"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN9170"/>
    <dbReference type="eggNOG" id="KOG1263">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006504_3_2_1"/>
    <dbReference type="InParanoid" id="Q5ARB0"/>
    <dbReference type="OMA" id="TGAWAFH"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052716">
        <property type="term" value="F:hydroquinone:oxygen oxidoreductase activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd13854">
        <property type="entry name" value="CuRO_1_MaLCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13880">
        <property type="entry name" value="CuRO_2_MaLCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13901">
        <property type="entry name" value="CuRO_3_MaLCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000021">
        <property type="entry name" value="Extracellular dihydrogeodin oxidase/laccase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000038">
        <property type="entry name" value="Extracellular dihydrogeodin oxidase/laccase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF71">
        <property type="entry name" value="OXIDOREDUCTASE TPCJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0186">Copper</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010244982" evidence="7">
        <location>
            <begin position="25"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="10">
        <location>
            <begin position="68"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="8">
        <location>
            <begin position="193"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="9">
        <location>
            <begin position="406"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CBF82396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="570" mass="64460" checksum="7E9FF0A64F3D0CAC" modified="2005-04-26" version="1">MAQLWGWISVYCLLILSFTVRSLGQEQSAFCEHSSLARECWGQYNISTDYHAITPDTGVTREYWLVAENTTLAPDGYERQVLVFNGTLPGPLIEANWGDELVIHVTNGLEHNGTAIHWHGIWQRGTNQYDGVPGVTQCPISPGQTYTYRFRATQYGTTWYHSHFSLQLAEGLFGPLVIHGPASADYDVDLGSVFISDWYHKSAFILWEESTRYGGVPVRANAVPPTGLFNGSNVFGGGGRRSEMIVEKGKKYRLRLIDSSVDGWMKFSIDGHKLTVISADLVPIEPYETDAVILTSGQRYDVVFEANQKIGNYWTRVIYQTACNGLDIKDPDIRGILRYAGAEISDPTSSQWSSIRNSCGDEPYDKLVPYVKRTVGKAAGQENLNVGWYYDLPELYFHWTLNTKALTIDWGTPTNKLIYNNESVFPTEYNIYEVPNRDQWTYWVIQDVGLVNAYHPFHLHGHDFFILAQGRGLYTPLVKLNRDNPPRRDTATMAGNGFLVIAFESDNPGSWLMHCHIAWHASQSLALQFVERESEIGPLIEPVIGEIESDCKKWEKYHAESVYHQDDSGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ARG5</accession>
    <accession>C8VK86</accession>
    <name>Q5ARG5_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Xylose isomerase-like TIM barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ANIA_09115</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
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            <dbReference type="DOI" id="10.1038/nature04341"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
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    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
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                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
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                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
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            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
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        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
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            <dbReference type="EMBL" id="CBF82517.1"/>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    </evidence>
    <sequence length="298" mass="34000" checksum="B4EE40B479E70FDF" modified="2005-04-26" version="1">MVVISRFRSLWGVEPGPQQSEWKQKFVEWKAHGYGTVLSGIEIDFAGMSPEELQLLRSICDEYSSYAASNRSSLFSSWPKYIGRRPPGLTTDDHAEFFRSQLRLASILKPVRVNAQSGADHFSWDDSVAFYKKALQVEKEEGFDGRVCHETHRNRSLFNPYAADYILQKVPELTITADISHWVVVCERLLDRNEEDQDILKRVIPHVGHIHTRMGTTQASQCPEPLNQAFAEERAFFEKFWLDIVKHKQQTDSNGRLTFVPEYGPFPYHPIGTAQSHGDLADSEGARLEKLFKSAVGQ</sequence>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
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                <person name="Asai K."/>
                <person name="Machida M."/>
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                <person name="Denning D.W."/>
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                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
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            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
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                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
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            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
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        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
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        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="CBF82574.1"/>
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    </evidence>
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        <source>
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    <reference evidence="6" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
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                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
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                <person name="Denning D.W."/>
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                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF82637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="XP_682326.1">
        <property type="nucleotide sequence ID" value="XM_677234.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ARM3"/>
    <dbReference type="STRING" id="227321.Q5ARM3"/>
    <dbReference type="GeneID" id="2868122"/>
    <dbReference type="KEGG" id="ani:ANIA_09057"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN9057"/>
    <dbReference type="eggNOG" id="ENOG502RGNJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016357_0_0_1"/>
    <dbReference type="InParanoid" id="Q5ARM3"/>
    <dbReference type="OMA" id="YRMYIEE"/>
    <dbReference type="OrthoDB" id="4115389at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025676">
        <property type="entry name" value="Clr5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056669">
        <property type="entry name" value="DUF7767"/>
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    <dbReference type="InterPro" id="IPR057940">
        <property type="entry name" value="Tri-helical_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38788">
        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38788:SF5">
        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14420">
        <property type="entry name" value="Clr5"/>
        <property type="match status" value="1"/>
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            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
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            <begin position="204"/>
            <end position="287"/>
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        <location>
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            <end position="383"/>
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    <feature type="domain" description="DUF7767" evidence="4">
        <location>
            <begin position="482"/>
            <end position="573"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBF82637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="574" mass="65770" checksum="5599630B10DB6969" modified="2005-04-26" version="1">MVYDWDGKREICYQMYIKDRKALEEIMEYMRNVYQFSPSKRAFQTQFKRWGFPSKQNPAHKNLQLVTRVKQLWETNTSQRDMLRILNEEGFQIKERELMRVRAKNRWLLRVPNGTKAQQVALSSPQTEDDSLLALQEYQPDPQDVADSSEAALKRKERLDRLQAESAERWAARKRRRRTRGWAGLPADPPGPPRFPSETTIDESKKYLKLDNAGYRQIRDQFQSICEKAGFIKKTIAGPEKWQEAKNTLIQNSEHLQRVFWDDPDQLEAKSLALDVVCTDVTKRMRTLERRMTIAEAKNVLGINPEESRQIRNAFYNTLRNDHFTSKLEAGDEHWKELKEQWVQGSELLQRVLAPGSADPKHATKLRALEVLCRDVMKRLRDDQTKRDPSRRRLAANPNIRVAERASTDLTGPFDCDISNGISSLASEALASAPITSSDLGDMQIDPSLLQAANNTSFTPTVHHDPGSAFGYVDSILDSTIMPMTVYLSISPESELHADSKPWVDKLSTKSATELRQLVSARFPDSIVVKIEAFDGDTNENNATYSINDDDELYGYMAHLQGRKAVFAFWLSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ARM4</accession>
    <accession>C8VKP2</accession>
    <name>Q5ARM4_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_09056</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF84379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_682325.1">
        <property type="nucleotide sequence ID" value="XM_677233.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ARM4"/>
    <dbReference type="GeneID" id="2868162"/>
    <dbReference type="KEGG" id="ani:ANIA_09056"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN9056"/>
    <dbReference type="eggNOG" id="ENOG502REJ5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_509017_0_0_1"/>
    <dbReference type="InParanoid" id="Q5ARM4"/>
    <dbReference type="OrthoDB" id="5414836at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38122">
        <property type="entry name" value="GLYCOPROTEIN X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38122:SF1">
        <property type="entry name" value="GLYCOPROTEIN X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="304"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF84379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="535" mass="57736" checksum="A4039843B90AC000" modified="2005-04-26" version="1">MGLFSRDRGEPWDLGIRGLSLAVSGRTPTTIFSSGLTIYPSQCLPQDSMLDCYRDRVAAAAMALQRSRMNPRAAIFLNDSHKAVSVQIQPSAAMSSPIPVGVFFNIFALRRIRRRETTSSSTDLDSQEIPNVCYETCNGAFLEAAGRGKMAAICADGSTFSDLVDQCRQCIELFVNSPSSNSTASASSGSTTAELNEFIAYCDEQGGGSGNSNVTLVKEIDSLLASYSSLSSSQSQLQASLSSLGYTGDFPELTSATATGDVTASSTSMVGPTATAGGEDRSFSNEGGTGTEDLPSSDTSDINIIAPAVIVPVFALLVGSVLAWALIRRRRKRQGTEEIGAAGDSFDDKAQLHADEFRPELDGLAIAKKRLVNMDEDLAELPAREPIGAELDGLGRIPSNLGMYNHDRLGALIQFFNITKKPKEFIGSWDNRIVNALNPSSMLTSQEQRDPSPGQLHRIGASGNGELYSDSLAMRCSCTVVHKSVMNAQRGKGRRKLHLDLFNPTHETRQEMGWLDLSFMQCRLSALRFKYSMIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="122" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ART1</accession>
    <accession>C8VL03</accession>
    <name>Q5ART1_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GH18 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ANIA_08999</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF84489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="XP_682268.1">
        <property type="nucleotide sequence ID" value="XM_677176.2"/>
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    <dbReference type="AlphaFoldDB" id="Q5ART1"/>
    <dbReference type="GeneID" id="2868289"/>
    <dbReference type="KEGG" id="ani:ANIA_08999"/>
    <dbReference type="eggNOG" id="KOG4177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_375061_0_0_1"/>
    <dbReference type="InParanoid" id="Q5ART1"/>
    <dbReference type="OMA" id="STCCASQ"/>
    <dbReference type="OrthoDB" id="341259at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
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    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
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    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
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    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24173">
        <property type="entry name" value="ANKYRIN REPEAT CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24173:SF74">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="58"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
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        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
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        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
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            <begin position="193"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
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            <begin position="297"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="5">
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            <begin position="533"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
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            <begin position="705"/>
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        <location>
            <begin position="416"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
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            <begin position="716"/>
            <end position="726"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="727"/>
            <end position="740"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00704"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CBF84489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="740" mass="81643" checksum="FB47F44230C8F4A1" modified="2005-04-26" version="1">MAKQIQPKPSALATLIPELQWLIFNCLSFDDKVLFTEIGLFHPDLLTSHGQTNTYDQHGRTLLHVAAEKGCVRAAQHLLCGGATPSAKMGPGARDFNTTPLILAAQQENKELVNLLLSHGADVNDWDYSGITALHYAVIRGDGRIVRILLDKGAKQTNNYDIGCPVHVAAASGALEILRLLVAHGADVGASKRGLSALDIALLNGNIAAARILVDAGAPLNDPVEGWGLFNPTLMVAGGPHAADAAEIVLDHSIASIDSVARQREVEEWWKPRQKGEYAELLQAMLVAGADPNQTFRSATPLHLAVVAGNEHAVRVLLEAGADVHARTDRALQRKEERERVGGSTCCASQAGAFQCIWPLIFASISGVQSRSSISSVLRQPGNLCCFTPSLFARFKAHGENACLLFVERSDETRASAQSRGPGCQDSSTHLPAPIPIPMRRGAGSWRARRNVLRFRPMYQGCCSKDYSSGFTPEHCDTGRISDCNATAEYGQLCAPTSSDTEVSPRIFAAMAVKRTPTALDVASQSAMSFKRRIGYYELFNYYKGCNVIEPESLIIEPFTHINLAFVNLGDDYTLIDEYGNIADCVLFLKFSNPGLRVNIAVGGWVFSDAPTQHLWTQMARSHEKQQTFINSVVKYPQDYPRGCRASAQWQEVMNRLWQQSEKPLSPENFPGRMNRNDDMRLEARNREIKRTPFTYYSRHNHPACQTRIHQWKKEKKVDEREEGDKTTNYPAAKSQSPKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ARU3</accession>
    <accession>C8VL15</accession>
    <name>Q5ARU3_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_08987</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF84512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_677164.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ARU3"/>
    <dbReference type="GeneID" id="2868183"/>
    <dbReference type="KEGG" id="ani:ANIA_08987"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN8987"/>
    <dbReference type="HOGENOM" id="CLU_804172_0_0_1"/>
    <dbReference type="InParanoid" id="Q5ARU3"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="194"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF84512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="345" mass="38895" checksum="E09F945AC771E27E" modified="2005-04-26" version="1">MVLAQRLLGVLLVDIGLLQLVVVVSRNRAGVYLTQYTPRVRRKLNRNSTEMCINLRGYSRLSMGVVELTIRLRGSWRLSMWAGQHRDVDGHSLSPLTDVAVNQRAIFQNGLRKQRSMRYCSLVLLLEGQAVIDIRSQWGGLAVKIGPEWARLQNCRPGENPVTLSGEDHRIVMGWRYRAASGLIRRPSPAWLDSSPVSNSQQQSPGKPQQDHALMAEMMMKKKQRVVIAKLSTRSLREEETCAAGGSRSPAPFPPVILWSATFSSLTAALCLNWPSRLAWTSHQPQGQISGDNPEHQNDKTFEHVDDTPVDHHEERKSGSNERYVHLFLHVNTMLLPWITVAHQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="121" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ASI6</accession>
    <accession>C8V9Z8</accession>
    <name>Q5ASI6_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">FMN dependent dehydrogenase, putative (AFU_orthologue AFUA_6G02720)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ANIA_08744</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF78116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_682013.1">
        <property type="nucleotide sequence ID" value="XM_676921.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ASI6"/>
    <dbReference type="STRING" id="227321.Q5ASI6"/>
    <dbReference type="GeneID" id="2868383"/>
    <dbReference type="KEGG" id="ani:ANIA_08744"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN8744"/>
    <dbReference type="eggNOG" id="KOG0538">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020639_0_1_1"/>
    <dbReference type="InParanoid" id="Q5ASI6"/>
    <dbReference type="OMA" id="CMLADTD"/>
    <dbReference type="OrthoDB" id="25826at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03332">
        <property type="entry name" value="LMO_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000132">
        <property type="entry name" value="FMN dependent dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012133">
        <property type="entry name" value="Alpha-hydoxy_acid_DH_FMN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008259">
        <property type="entry name" value="FMN_hydac_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037350">
        <property type="entry name" value="LMO_FMN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578:SF86">
        <property type="entry name" value="DEPENDENT DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G02720)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578">
        <property type="entry name" value="S -2-HYDROXY-ACID OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000138">
        <property type="entry name" value="Al-hdrx_acd_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00557">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 7" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="8">
        <location>
            <begin position="21"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="290"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="100"/>
            <end position="102"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="321"/>
            <end position="325"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="344"/>
            <end position="345"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBF78116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="403" mass="43813" checksum="00D1F5A045F55A2F" modified="2005-04-26" version="1">MSQNYGEYQQEIYGQGALMGLKPNVSTDARLLEEQARKALSDIAYNYVAGGAGEKATMDSNRLAFRQWKLIPKMLRKMDKQDISVNLFGQDYPTPLIMAPVGVQGLFHPDKETGLAEVCAETGVPYTLSTASTSSIEEVANASGDGKRWFQLYWPGDDDITLSLVKRAKENGYSVLVVTLDTWSLSWRPADLDNAYIPFIRGIGNQVGFSDPVFRAKFEKESGSKVEDDIVGASRAWISKVLSTTPHVWDEVSFLRKHWDGPLVLKGIQHVEDAKLALEAGCDGIVVSNHGGRQVDGAIASLEVLPEIVDAVGDKLTVLFDSGIRTGADIIKALCLGAKGVLVGRPVIYGLSIDGKNGAKAVIKGLQADLWQSMSLSGICTVAECTRDKIRKIQYPGDTKAML</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="113" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AST2</accession>
    <accession>C8VAC0</accession>
    <name>Q5AST2_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ANIA_08648</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF78260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_681917.1">
        <property type="nucleotide sequence ID" value="XM_676825.1"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5AST2"/>
    <dbReference type="GeneID" id="2868510"/>
    <dbReference type="KEGG" id="ani:ANIA_08648"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN8648"/>
    <dbReference type="eggNOG" id="KOG1075">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000680_23_0_1"/>
    <dbReference type="InParanoid" id="Q5AST2"/>
    <dbReference type="OMA" id="MATSNIC"/>
    <dbReference type="OrthoDB" id="4501366at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09276">
        <property type="entry name" value="Rnase_HI_RT_non_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000101">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
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    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="826"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="domain" description="RNase H type-1" evidence="3">
        <location>
            <begin position="1274"/>
            <end position="1420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBF78260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1581" mass="174387" checksum="E793EAAA2783CC37" modified="2005-04-26" version="1">MEVDDSPPGGARPGTPLLGENSEPPSGPTTPTPLPRNSLKRRALFSPQKTPTAAPVPVSHLPQAPSICEQVSMVADDQLVLLNDWKLAMTSLAKALDLTVSSLQGRPRDLARGLAARFVSLAKQDSPQQIPLMTAAAPPQPSRQMEQPNQPPTPEACEGPLKRRTSQPTTWASLTAPRAGQGNWQTIAPEHRTQAKQPAQRKLKQPNKTDHRIFLRLPASSSLRAIGPHGIRVTLAGKVPDGIAQVQVISTGYAITTTEQGKVFLLSEKAASLAGDGYFEIPTEYHQVIVPRIPKQLWSLDGWIDTTITDISNEAERITGIKPLMAKLSKHPVERDSITAVIAFPKRLQHPLQLFGLSGLSRPTRPKQRPLQCTRCHRFHDTRACRSSERCISCGSSKQEHNCRRGGAAHDLLLSFEADIILVQEPWTNTAKHLTKTHPRYQLFSPPTRWTARPRTLTYVRRDLPAHSLPEPISPDITTIYTAGLTIINVYRPPNDPVAPAGAGSTPSTLSTLLGYAPPENTILAGDFNTRHPFWQPDTESHAVTPGATGLLDWLDAHELELRLEPGTPTRGPNTLDLVFSNLPLRALVEDHLKTPSDHATIGIILEQEEPPPIYKLGSTNWEKARALASPPDPTLPIDLLAKQLVQTSQLAIQGASRYNTRRLPRTPWWTPELTDILHQTRQQQNPDYKQLRKAIVRAKAEYWKQRIEQATAPIDAFKLAKWIQHPDQLAAPPLNIQGAQVTTPQGKADAFLNHLLEKGALLPNQTEEGPPNKPLGSLHLPTKEHCWAALCAPPPSAPGEDGLATTAWRELWPVLGDTITQLYYRCMEEGCFPLSLKSAKVIMLPKPGKRGYTQLNAWRPISLLSTLGKGLERLLAQQIAVRAIQADVLAPCHFGALPGRSAIDLVQVLVHRVEEAFQQGKDASLLLLDVKGAFDAVIHQRLLSHLRLQGWHKGLLQLLKDWLTGRSVSVHIKEGTATAPIKGGLPQGSPLSPILFLLYAARIVSTLEGSFCYADDMGILLTGNTLEESSQQLVEAYKQITALGTETGLPFSIEKTEIQHFSRKQQQHLPTVTLPGIGEITPSLYTRWLGVLLDTKLTFKAHINLVFSRGKRLAQHLKRLSNTQRGCPVASMRAAVIQCVLPTALYGAEVFYTGKRQKGVVNSLLSLFRTAALAIIPAYKTTPTAALLREADLPDPEALLNSILRRAAVRYMSLDTKHPIAQIAAETTAGRPKTRLKRILQLLLSPLPERAIIELPLPPLCMLPTDNKGYSPAPLQISVYSDGSRTSQGAGYGYAIYFGPILVSKGHGPAGPRTEVYDAEIMGAVEGLRAALGQPCVGYSTQLVILLDNLAAASLLASYRPTPHRHGLSETFSQLAAQWMESPSILTMQRKPLQVRWIPGHSGIAGNELADKLAKLGSSIYSPDIPPSPAYLRREAKQWLRTETYTAYANKAPETYKALNIRPHTKESRSREHKLPRWVLGRLVAARTGHGDFTAYHQRFDHTDYLESCTCGKAKTPVHFFFCPYTRKRWKDRWRCIKDGPSKTIDWLLSTAAGAEEFSRIVQESSFFKDICPNWARRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ATF8</accession>
    <accession>C8VEC7</accession>
    <name>Q5ATF8_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ANIA_08422</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF80514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_681691.1">
        <property type="nucleotide sequence ID" value="XM_676599.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ATF8"/>
    <dbReference type="GeneID" id="2868635"/>
    <dbReference type="KEGG" id="ani:ANIA_08422"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN8422"/>
    <dbReference type="eggNOG" id="ENOG502SASX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_125562_1_0_1"/>
    <dbReference type="InParanoid" id="Q5ATF8"/>
    <dbReference type="OMA" id="AATWFDF"/>
    <dbReference type="OrthoDB" id="2017497at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032126">
        <property type="term" value="C:eisosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070941">
        <property type="term" value="P:eisosome assembly"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008253">
        <property type="entry name" value="Marvel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052649">
        <property type="entry name" value="NCE102-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28165:SF2">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28165">
        <property type="entry name" value="NON-CLASSICAL EXPORT PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01284">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="40"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="MARVEL" evidence="6">
        <location>
            <begin position="5"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBF80514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="179" mass="18837" checksum="51BF3FC05A0B77C4" modified="2005-04-26" version="1">MQIVNSIVRIFQAISAIIVLGISVDLARGQDTRLQSVPPATGYAAFCGGFGTLVSFIGIISLFISSLEGLITLSLDALSGVTMLASGIAYAVLLRHTDCSNAYYSEATWRNELLSGGCVEIGDGIGCRYGGREEEGKLKSRCASAKADTAFMFTSFVACIGIVGYSFFARGRGKGVSYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ATT3</accession>
    <accession>C8VDY6</accession>
    <name>Q5ATT3_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_08297</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF80255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_681566.1">
        <property type="nucleotide sequence ID" value="XM_676474.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ATT3"/>
    <dbReference type="GeneID" id="2868710"/>
    <dbReference type="KEGG" id="ani:ANIA_08297"/>
    <dbReference type="HOGENOM" id="CLU_1677867_0_0_1"/>
    <dbReference type="InParanoid" id="Q5ATT3"/>
    <dbReference type="OrthoDB" id="4367549at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF80255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="157" mass="17192" checksum="741C0EB009ABA3F4" modified="2005-04-26" version="1">MPAVCEPQIRQKHIRDGKTFSYVRNSNSEALLGEGKQYDFHIKNPATTTPKHARKRAAALAALVAGEEEEEDEEAEEEEDKEEEENARRRKGKAPATSARKGEALAQTLLLVAAEYADDAGFQGFGGEEEEEGEGGGDEDESELSLLDKEILTLGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AV37</accession>
    <accession>C8VDX1</accession>
    <name>Q5AV37_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_07843</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF80223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_681112.1">
        <property type="nucleotide sequence ID" value="XM_676020.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AV37"/>
    <dbReference type="GeneID" id="2869540"/>
    <dbReference type="KEGG" id="ani:ANIA_07843"/>
    <dbReference type="HOGENOM" id="CLU_1855255_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AV37"/>
    <dbReference type="OrthoDB" id="4500275at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF80223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="138" mass="14989" checksum="1C53F39E60EA5C96" modified="2005-04-26" version="1">MALNPNNAPADVPTNRPMSLEELEGLFARAIQATAPGQNLVLPIGGSRPGQAIAVNPGKVTAARVDSRRDLYVNALLIQSRGQRLEVPWEAGAADNPIDLDEEEEEEEEEEEEEDDDDDDDDDDNDDDDGGPNNPIQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AVJ4</accession>
    <accession>C8VC45</accession>
    <name>Q5AVJ4_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FHA domain protein (AFU_orthologue AFUA_2G01670)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_07686</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
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        <property type="entry name" value="Cent_Immune-Sig_Mod"/>
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        <property type="entry name" value="CENTROSOMAL PROTEIN OF 170 KDA"/>
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        <property type="entry name" value="FHA_DOMAIN"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="2">
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    <feature type="region of interest" description="Disordered" evidence="1">
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    <feature type="region of interest" description="Disordered" evidence="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50006"/>
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            <dbReference type="EMBL" id="CBF79902.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
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</entry>
<entry dataset="Swiss-Prot" created="2005-07-19" modified="2026-01-28" version="110" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AWA2</accession>
    <accession>C8VBA1</accession>
    <name>ATG7_EMENI</name>
    <protein>
        <recommendedName>
            <fullName>Ubiquitin-like modifier-activating enzyme atg7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>ATG12-activating enzyme E1 atg7</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Autophagy-related protein 7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">atg7</name>
        <name type="ORF">AN7428</name>
    </gene>
    <organism>
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates atg12 for its conjugation with atg5 and atg8 for its conjugation with phosphatidylethanolamine. Both systems are needed for the atg8 association to Cvt vesicles and autophagosomes membranes. Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Plays a role in the regulation of filamentous growth and chronological longevity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Preautophagosomal structure</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">The GxGxxG motif is important for the function, possibly through binding with ATP.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATG7 family.</text>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="erroneous gene model prediction">
            <sequence resource="EMBL-CDS" id="CBF79362" version="1"/>
        </conflict>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="erroneous gene model prediction">
            <sequence resource="EMBL-CDS" id="EAA62008" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EMBL" id="AACD01000129">
        <property type="protein sequence ID" value="EAA62008.1"/>
        <property type="status" value="ALT_SEQ"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF79362.1"/>
        <property type="status" value="ALT_SEQ"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AWA2"/>
    <dbReference type="SMR" id="Q5AWA2"/>
    <dbReference type="FunCoup" id="Q5AWA2">
        <property type="interactions" value="736"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5AWA2"/>
    <dbReference type="eggNOG" id="KOG2337">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012998_2_1_1"/>
    <dbReference type="InParanoid" id="Q5AWA2"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019778">
        <property type="term" value="F:Atg12 activating enzyme activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019779">
        <property type="term" value="F:Atg8 activating enzyme activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032446">
        <property type="term" value="P:protein modification by small protein conjugation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000243">
        <property type="entry name" value="Ubiquitin-like modifier-activating enzyme ATG7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.70:FF:000001">
        <property type="entry name" value="Ubiquitin-like modifier-activating enzyme atg7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.100">
        <property type="entry name" value="Ubiquitin-like modifier-activating enzyme ATG7 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.70">
        <property type="entry name" value="Ubiquitin-like modifier-activating enzyme ATG7 N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006285">
        <property type="entry name" value="Atg7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032197">
        <property type="entry name" value="Atg7_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042522">
        <property type="entry name" value="Atg7_N_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042523">
        <property type="entry name" value="Atg7_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01381">
        <property type="entry name" value="E1_like_apg7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF3">
        <property type="entry name" value="UBIQUITIN-LIKE MODIFIER-ACTIVATING ENZYME ATG7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16420">
        <property type="entry name" value="ATG7_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0072">Autophagy</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0653">Protein transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <keyword id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="chain" id="PRO_0000212815" description="Ubiquitin-like modifier-activating enzyme atg7">
        <location>
            <begin position="1"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXGXXG motif" evidence="1">
        <location>
            <begin position="363"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="1">
        <location>
            <position position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="662" mass="73420" checksum="E5A8E28C6B51A80C" modified="2011-11-16" version="2">MQYTPFASDIELPFYIALASLKINHDKLDDSARKVLGLYELRPSDAPNASCRIQIHGNALTSDEVPSTYYRAEGMIKNVNTIEEYAKADKMGMLQQSGETIWNAINNGTIYSCPSLLSAFVILSYADLKKYKFHYWFAFPALHSDPSWTPLEEGCEGAQAHRLPSVESSALARSVQEWARVVDAPQRGFFLARRVRMRDDDTVSWKIASLSSYEDGFFKHAEFADCFTCFVDPSNYEEAPGWMLRNLLVLVKRRWGLTKVQILRYRDGPSPRDCGRSIVVTLRLKTSQLPDGGVKDDRMPKVTGWERNPSGKLTGRIVDLTEQLDPKRLADQSVDLNLKLMKWRISPNLDLEKIKGTKCLLLGAGTLGSYVARNLMAWGVRKITFVDNGSVSFSNPVRQPLFNFADCLDGGAKKAYRASQALSEIYPGVESVGHVLAVPMAGHPVLDAEKTKADFEVLKGLIDAHDVIILLMDTRESRWLPTVMGKAAGKIVMNAALGFDTFVVMRHGVTNNEHPEEELGCYFCNDVVAPMNSQKDQTLDQQCTVTRPGVAAIASALLVELLVSLLQHPLGAAAGAPQTPNNTQNDHPLGVIPHQIRGFLSTFENVSVVGRSYKCCSACSRPVIDEYKKNGWNFVQKALNEVGYVEELSGLKEVCHPPLSIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AWH3</accession>
    <accession>C8VCJ3</accession>
    <name>Q5AWH3_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ANIA_07357</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF78552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_680626.1">
        <property type="nucleotide sequence ID" value="XM_675534.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AWH3"/>
    <dbReference type="GeneID" id="2869777"/>
    <dbReference type="KEGG" id="ani:ANIA_07357"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN7357"/>
    <dbReference type="eggNOG" id="ENOG502SQ3U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1618617_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AWH3"/>
    <dbReference type="OMA" id="FEHEMED"/>
    <dbReference type="OrthoDB" id="3880384at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF78552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="163" mass="19194" checksum="1088F6E44687021F" modified="2005-04-26" version="1">MAPNLFLCLRTVFCPTYWFQRGQRIQGSISREEHWDSPVPGIYKYIPSQGWHLVCRDGSDYDEKVPVPVVYCRILHRYLFEDEVNERCRWHTVTLDGGKTEKLLFFQLDDGYTYVAGWDSKGKFIPGPYQRWYLDPETKTMQKVFFPPSSNVSRVSITPDKLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AWW1</accession>
    <accession>C8VCZ6</accession>
    <name>Q5AWW1_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_07219</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF78831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_680488.1">
        <property type="nucleotide sequence ID" value="XM_675396.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AWW1"/>
    <dbReference type="STRING" id="227321.Q5AWW1"/>
    <dbReference type="GeneID" id="2870063"/>
    <dbReference type="KEGG" id="ani:ANIA_07219"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN7219"/>
    <dbReference type="HOGENOM" id="CLU_871626_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AWW1"/>
    <dbReference type="OMA" id="QAINICT"/>
    <dbReference type="OrthoDB" id="3555317at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40618:SF1">
        <property type="entry name" value="B-ZIP TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40618">
        <property type="entry name" value="B-ZIP TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF78831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="319" mass="34671" checksum="4709B70101BC9416" modified="2005-04-26" version="1">MSCTALILSNQRRRQQVLLAQTGVPGTKRGTHQGATAAVARLESALERMCQAIISSTDVVIGARIPTSHQQIAHRLRDTVKTCLLSAMDGNGCQDDFACSNQSEQLPKQSQAQGDHEKWPRPSQHAGLGVLPPARNAPFAPQSMPPAADATTMKAALFANQLRLYARLNNKQPDRCSDIPYFRLGGAGTHYSGVSGQNQTELGKEQNSREIRIPDTLSAFSPEVQKDLDGDWFDLFDLVGYVRTHGVALSMAPPVEDTAYRKVNAVDFAAGRLTFRVLCHARGGYLTIISSGRKGICLGHSPGFKRSDVEIAIDSSCWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="113" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AXA5</accession>
    <accession>C8VDG3</accession>
    <name>Q5AXA5_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ANIA_07075</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF79136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_664679.1">
        <property type="nucleotide sequence ID" value="XM_659587.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AXA5"/>
    <dbReference type="STRING" id="227321.Q5AXA5"/>
    <dbReference type="GeneID" id="2869979"/>
    <dbReference type="KEGG" id="ani:ANIA_07075"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN7075"/>
    <dbReference type="eggNOG" id="KOG1231">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018354_1_2_1"/>
    <dbReference type="InParanoid" id="Q5AXA5"/>
    <dbReference type="OMA" id="ATLWAHA"/>
    <dbReference type="OrthoDB" id="2151789at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF22">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010179225" description="FAD-binding PCMH-type domain-containing protein" evidence="5">
        <location>
            <begin position="18"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="56"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBF79136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="486" mass="53903" checksum="30BBA9E45170A90D" modified="2005-04-26" version="1">MYWFILHLLAVALPAAALVTHDPCRLVESKIPGRISYPSSTTYNASVSSYYDDQERSLRPGCIFRPTNTSEVSQFVKLMTADKRKPQFAVRGGGHTLWTGAANIGPGITVDMRLMDQLELSEDKKIARIGGGAVWDHIYPQLVPHDLTVMGGRIPGIGVGGFAMGGGITFSSREHGFSCDNIYGYEIVLGNGQVIYADQRSHPDLWLALKGGSNNFGIITRFDAATIPLGKMWYNHLHYNYTDSALQAHAEAFSDFMKPENYDGAAMMGVFLDYLGGKFLLHDALWYTREVENPAVYDAFTEIPNLGGVAELNTIDNVVDKFGDDIPSQVGRAFQLTFSFHNPDPTVYMELFKIWETGLSKIANVEGLFVEFLTQPHPVTNGTNLFGLTPGRTDDVMVDMTAAYTNQADDRLVQSVITDIVNEQRALLKRSGHLMDFIYLNYADISQEVLQSWGADNVAKLRAASNKYDPKRVFQKQVPGGFKIPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AXL9</accession>
    <accession>C8V3E8</accession>
    <name>Q5AXL9_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NRPS-like enzyme, putative (JCVI)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ANIA_06961</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
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                <person name="Flipphi M."/>
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                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
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                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
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            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
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        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
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        <property type="entry name" value="CARRIER"/>
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    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
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        <location>
            <begin position="33"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
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        <source>
            <dbReference type="EMBL" id="CBF71839.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
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    <sequence length="179" mass="19499" checksum="4EE1685817665E35" modified="2005-04-26" version="1">MTPNGKLDRKALRTLPLPAAQPIRENRMKTKHPPLNVAEGELSRLWRQILGDVVGGASIQAETDFFAIGGSSLQLVRLQNALRERMGVEASLHDIYRLSSLGKMAALMCDERGRLESDAIDWSAETDIPHVQTVIETAAVSNVSDHQFEITGTLRQKKEVVLTGATGFLGSEILKGAIA</sequence>
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<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AXU9</accession>
    <accession>C8V2Q9</accession>
    <name>Q5AXU9_EMENI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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        <name evidence="2" type="ORF">ANIA_06881</name>
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        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
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            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
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            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
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    <dbReference type="HOGENOM" id="CLU_121100_1_0_1"/>
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        <property type="component" value="Chromosome I"/>
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        <location>
            <begin position="1"/>
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        <location>
            <begin position="1"/>
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        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="CBF71653.1"/>
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        <source>
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<entry dataset="Swiss-Prot" created="2008-04-29" modified="2026-01-28" version="118" xmlns="https://uniprot.org/uniprot">
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        <recommendedName>
            <fullName>Mitochondrial division protein 1</fullName>
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    <reference key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
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            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in mitochondrial fission. Acts as an adapter protein required to form mitochondrial fission complexes. Formation of these complexes is required to promote constriction and fission of the mitochondrial compartment at a late step in mitochondrial division.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the WD repeat MDV1/CAF4 family.</text>
    </comment>
    <comment type="sequence caution" evidence="4">
        <conflict type="erroneous gene model prediction">
            <sequence resource="EMBL-CDS" id="EAA58266" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EMBL" id="AACD01000113">
        <property type="protein sequence ID" value="EAA58266.1"/>
        <property type="status" value="ALT_SEQ"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF71624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AXW3"/>
    <dbReference type="SMR" id="Q5AXW3"/>
    <dbReference type="FunCoup" id="Q5AXW3">
        <property type="interactions" value="82"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5AXW3"/>
    <dbReference type="EnsemblFungi" id="CBF71624">
        <property type="protein sequence ID" value="CBF71624"/>
        <property type="gene ID" value="ANIA_06867"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AN6867"/>
    <dbReference type="eggNOG" id="KOG4155">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012350_1_1_1"/>
    <dbReference type="InParanoid" id="Q5AXW3"/>
    <dbReference type="OMA" id="ERLRYMD"/>
    <dbReference type="OrthoDB" id="496at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd22881">
        <property type="entry name" value="Mdv1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000404">
        <property type="entry name" value="Mitochondrial division protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000881">
        <property type="entry name" value="Mitochondrial division protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19855:SF28">
        <property type="entry name" value="CCR4-ASSOCIATED FACTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19855">
        <property type="entry name" value="WD40 REPEAT PROTEIN 12, 37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0853">WD repeat</keyword>
    <feature type="chain" id="PRO_0000330105" description="Mitochondrial division protein 1">
        <location>
            <begin position="1"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 1">
        <location>
            <begin position="323"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 2">
        <location>
            <begin position="365"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 3">
        <location>
            <begin position="433"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 4">
        <location>
            <begin position="478"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 5">
        <location>
            <begin position="538"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 6">
        <location>
            <begin position="577"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 7">
        <location>
            <begin position="623"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="135"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="249"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="209"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="139"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="249"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="654" mass="72066" checksum="9DC5456C81F22914" modified="2008-04-29" version="2">MDKHRRDDSPSGLSDIVERDGLLGTGITSRHIEAFGRKVTSTAGHLMGPSGDPSTSTHYQNAMVDIHRELRRPSTQRKVFALAQTTPTDLVRSKLSTSEIQSRAISSLPDELLLNIPDDTSSYSLFEGFQATQNDHEYRKAHRRGRSKGKKLLKDKDGEQADPPSTLTELKKERDLLSRRMELMGVRKNMCSSEIVDIDNKIANFHRMRQIVLDRLAGLEMEEAELEHEVNEIDNKLDDMAEEEAAQAAQAAAAAAAATTAGSETHEEPASEDPAMDASFMSESIYQKLPSPRSLKHRSIRKRSMPVLHEHFAPGSEIKEFQAHTDVVTALDLDYPFGTMITAALDDTVRVWDLNIGRCTGFLEGHNASVRCLQIEDNVVATGSMDATVKLWDLSRARTTHRDNRVNKDEDDDAVSVAYSTSLEDCHVYSLDAHVGEVTALHFKGNTLVSGSADKTLRHWDLVKGRCVQTLDVLWAAAQASSLGNESQWRPSGRLPDASADFVGAVQCFDAALACGTADGMVRLWDLRSGQVHRSLVGHTGPVSCLQFDDVHLVTGSLDRSIRIWDLRMGSIYDAYGYDKPVTSMMFDTKRIVAAAGENVVKVYDKADGHHWDCGAGVGADETGPDPAIVERVRLKDGFLIEGRRDGIVAAWTC</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2025-02-05" modified="2026-01-28" version="131" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AY42</accession>
    <accession>C8V278</accession>
    <name>TF88_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription factor AN6788</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ORF">AN6788</name>
        <name type="ORF">ANIA_06788</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2012" name="J. Am. Chem. Soc." volume="134" first="8212" last="8221">
            <title>Illuminating the diversity of aromatic polyketide synthases in Aspergillus nidulans.</title>
            <authorList>
                <person name="Ahuja M."/>
                <person name="Chiang Y.M."/>
                <person name="Chang S.L."/>
                <person name="Praseuth M.B."/>
                <person name="Entwistle R."/>
                <person name="Sanchez J.F."/>
                <person name="Lo H.C."/>
                <person name="Yeh H.H."/>
                <person name="Oakley B.R."/>
                <person name="Wang C.C."/>
            </authorList>
            <dbReference type="PubMed" id="22510154"/>
            <dbReference type="DOI" id="10.1021/ja3016395"/>
        </citation>
        <scope>IDENTIFICATION</scope>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2024" name="J. Nat. Prod." volume="0" first="0" last="0">
            <title>Transcription Factor Engineering in Aspergillus nidulans Leads to the Discovery of an Orsellinaldehyde Derivative Produced via an Unlinked Polyketide Synthase Gene.</title>
            <authorList>
                <person name="Rabot C."/>
                <person name="Grau M.F."/>
                <person name="Entwistle R."/>
                <person name="Chiang Y.M."/>
                <person name="Zamora de Roberts Y."/>
                <person name="Ahuja M."/>
                <person name="Oakley C.E."/>
                <person name="Wang C.C.C."/>
                <person name="Todd R.B."/>
                <person name="Oakley B.R."/>
            </authorList>
            <dbReference type="PubMed" id="39334518"/>
            <dbReference type="DOI" id="10.1021/acs.jnatprod.4c00483"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="3 5">Transcription factors AN6788 and AN6790 act in tandem to regulate the expression of the non-reducing polyketide synthase pkfA from the aspernidine A biosynthesis cluster (PubMed:39334518). They do not control the expression of the other genes involved in aspernidine A biosynthesis, nor do they regulate the expression of the highly reducing polyketide synthase AN6791 and the esterase AN6793 with which they are predicted to form a secondary metabolite biosynthesis cluster (Probable) (PubMed:39334518).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF71461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_664392.1">
        <property type="nucleotide sequence ID" value="XM_659300.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AY42"/>
    <dbReference type="EnsemblFungi" id="CBF71461">
        <property type="protein sequence ID" value="CBF71461"/>
        <property type="gene ID" value="ANIA_06788"/>
    </dbReference>
    <dbReference type="GeneID" id="2870315"/>
    <dbReference type="KEGG" id="ani:ANIA_06788"/>
    <dbReference type="eggNOG" id="ENOG502SH49">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011017_3_1_1"/>
    <dbReference type="InParanoid" id="Q5AY42"/>
    <dbReference type="OMA" id="FWVAYCF"/>
    <dbReference type="OrthoDB" id="3037908at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF3">
        <property type="entry name" value="C6 FINGER DOMAIN TRANSCRIPTION FACTOR DBAA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_0000461774" description="Transcription factor AN6788">
        <location>
            <begin position="1"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Zn(2)-C6 fungal-type" evidence="1">
        <location>
            <begin position="25"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="113"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="39334518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="4">
        <source>
            <dbReference type="PubMed" id="39334518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5">
        <source>
            <dbReference type="PubMed" id="22510154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBF71461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="645" mass="72847" checksum="26A67AE8E20D71A7" modified="2005-04-26" version="1">MPQKAQPQPRESPFKPARQQPGLACEECRKRKARCDRAKPQCGSCMMTGRVCVVNHNRPRRGPKKGQIESLYSRLGRFIHGSLCISCWKAGMLTVTEVLEEQVIEQMEHIYHPDFEPNSHPRHSQSHDRRQQSGPDSSPDTQHELPFLQSPPAARDADSAERALLPSPVSPVRAMTAQELSYARTGSNPTQNPGLDLILADLDQLYFDRVHPIAPFLHQQRHLSQREAESSVLARACLRSAMRTVAAAMSAQYRRFADSLYIETSRVVQELDTIERTPSLKQIQAVLLLAHYELLRMEENRALATVGRCFRLIQLARLQDTDPSTDAGAGRDFVKEEETRRTFWVAYCFDRFLTSRNEWPFTLQEEAIWIRLPVSESAFQIPRPPEQPMDYLHEAIASSGQKTLPPFAEYIVLATLHGRTMNLRRSALLLSTSTEASMFWERHRALSDIVEKRSALWSYSPSATTPLVTADPLTAFTCLLEKTLIIYLGKVGQTAREQLGGMSERRLIENANSAVQNLATSEQETLMNCHSHSRSFDIGTGGRGGHASGGLQRSAQTAAEFVALAKFMCPVNCFRICSDKSVRRLTLSFQMQYPAQQSFLLRMEMPPRLEKYGMNVGERGTGRIRAIDHASRLKVDERRAVRAYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="105" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AY60</accession>
    <accession>C8V259</accession>
    <name>Q5AY60_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Amino acid transporter (Eurofung)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ANIA_06770</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF71424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_664374.1">
        <property type="nucleotide sequence ID" value="XM_659282.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AY60"/>
    <dbReference type="STRING" id="227321.Q5AY60"/>
    <dbReference type="GeneID" id="2870300"/>
    <dbReference type="KEGG" id="ani:ANIA_06770"/>
    <dbReference type="eggNOG" id="KOG1286">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024512_1_0_1"/>
    <dbReference type="InParanoid" id="Q5AY60"/>
    <dbReference type="OMA" id="FMITISG"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43495">
        <property type="entry name" value="GABA PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43495:SF5">
        <property type="entry name" value="GAMMA-AMINOBUTYRIC ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="206"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="347"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="415"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="465"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="504"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="567"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="595"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="8">
        <location>
            <begin position="94"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="8">
        <location>
            <begin position="355"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="30"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="41"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBF71424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="666" mass="73975" checksum="EE1577EA68F769E0" modified="2005-04-26" version="1">MASNNTHGNDEYALNKLDDLTWLPRDWQPSAGLGDTLRVPETSSAQPDSMRSSSPGLSDSVPGAQGEQDDNNMEDIIITNHERDRVKRRLRGIHVFMITLSGVLGAGLYIRSGTVLRIGGPGAVLIAFTAMGLLAWTVMQCLGELLALWPISGALVEFVAKFVDEDLGTAVGIAYWFTYSINFAALIVAAAGVLDFWDPGKAIQGTIMFFVVPLFLVLLNSFGVQVMQLILQFVDVWLMSQIYGLTEVIGGSIKILGVLVVISCMITINVGGIAGEGGHIGTFTPELVQEVLQINGNSYAFSIAAFAYVGVDITAATALEARPDKRHSRDTAADVLKGRWPYISVRFVATWTSFLVWIIYFIAGFLMSLNVEWNDENLPRLSWLGSPSDKGGKFKTDSGFVISAVMSGIPGLADMITAIIFVTAVFSANTNLYVASRTLFGLTRRIQGDGWRFFAFFGKTNNYQVPVRAMLLSLVFMWVPFLYLSPHNSADTTISSLLEVLSQMGSVSCIIVWACECWAFIRFYNCLYRHRDELNASPQFARLRRFPSQGSEDLYPWRSHGQPVTMYLALFGCVFILAVADGAALWHNWVTPRFLSAYLSILCFIPLWLGIKYYNNWGSVQWRLEDLSNFALVRRKLEELDEIHDLATSKDDEVQEKGWGNLWGFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AYU3</accession>
    <accession>C8V0L9</accession>
    <name>Q5AYU3_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_06537</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF70939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_664141.1">
        <property type="nucleotide sequence ID" value="XM_659049.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AYU3"/>
    <dbReference type="GeneID" id="2870226"/>
    <dbReference type="KEGG" id="ani:ANIA_06537"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN6537"/>
    <dbReference type="eggNOG" id="ENOG502SG61">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_123414_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AYU3"/>
    <dbReference type="OMA" id="GGCIWQE"/>
    <dbReference type="OrthoDB" id="3979469at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038882">
        <property type="entry name" value="Rcf3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39153">
        <property type="entry name" value="AGR244WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39153:SF1">
        <property type="entry name" value="AGR244WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF70939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="157" mass="17909" checksum="19D78FDFFABD90C8" modified="2005-04-26" version="1">MPPPSSQRADVEPPEEITSEAVRGFLAGAFRFGSVSILAHMIMILPHPFKFSPNTSGPPQHMQEHGQRPPGPSPFSKDYIRSRLFYRPLEGFSEWLSPTSKIYRGLTLQFKVFLQIAAMTLGGCIWAEHRVNAYINNIRKVKRAERLQAQREARFQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="116" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AZD4</accession>
    <accession>C8V0Z3</accession>
    <name>Q5AZD4_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">dihydroxy-acid dehydratase</fullName>
            <ecNumber evidence="14">4.2.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">ANIA_06346</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="20">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(2R)-2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:24809"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:49072"/>
            <dbReference type="EC" id="4.2.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:24810"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>(2R,3R)-2,3-dihydroxy-3-methylpentanoate = (S)-3-methyl-2-oxopentanoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:27694"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:49258"/>
            <dbReference type="EC" id="4.2.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:27695"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="13">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 3/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 3/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IlvD/Edd family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.9" evidence="14"/>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF69653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_663950.1">
        <property type="nucleotide sequence ID" value="XM_658858.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AZD4"/>
    <dbReference type="FunCoup" id="Q5AZD4">
        <property type="interactions" value="421"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5AZD4"/>
    <dbReference type="GeneID" id="2871247"/>
    <dbReference type="KEGG" id="ani:ANIA_06346"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN6346"/>
    <dbReference type="eggNOG" id="KOG2448">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014271_4_2_1"/>
    <dbReference type="InParanoid" id="Q5AZD4"/>
    <dbReference type="OMA" id="STQGRNM"/>
    <dbReference type="OrthoDB" id="3851628at2759"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00057"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00061"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004160">
        <property type="term" value="F:dihydroxy-acid dehydratase activity"/>
        <property type="evidence" value="ECO:0000247"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009082">
        <property type="term" value="P:branched-chain amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0000247"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.30.80:FF:000001">
        <property type="entry name" value="Dihydroxy-acid dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.80">
        <property type="entry name" value="IlvD/EDD C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00012">
        <property type="entry name" value="IlvD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050165">
        <property type="entry name" value="DHAD_IlvD/Edd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042096">
        <property type="entry name" value="Dihydro-acid_dehy_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004404">
        <property type="entry name" value="DihydroxyA_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020558">
        <property type="entry name" value="DiOHA_6PGluconate_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056740">
        <property type="entry name" value="ILV_EDD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000581">
        <property type="entry name" value="ILV_EDD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037237">
        <property type="entry name" value="IlvD/EDD_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00110">
        <property type="entry name" value="ilvD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002068">
        <property type="entry name" value="PRK00911.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21000">
        <property type="entry name" value="DIHYDROXY-ACID DEHYDRATASE DAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21000:SF5">
        <property type="entry name" value="DIHYDROXY-ACID DEHYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24877">
        <property type="entry name" value="ILV_EDD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00920">
        <property type="entry name" value="ILVD_EDD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143975">
        <property type="entry name" value="IlvD/EDD N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00886">
        <property type="entry name" value="ILVD_EDD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00887">
        <property type="entry name" value="ILVD_EDD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dihydroxy-acid/6-phosphogluconate dehydratase N-terminal" evidence="17">
        <location>
            <begin position="76"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="Dihydroxy-acid/6-phosphogluconate dehydratase C-terminal" evidence="18">
        <location>
            <begin position="408"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00052865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF24877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CBF69653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="613" mass="65294" checksum="A93BF5F1CF125325" modified="2005-04-26" version="1">MLLSQTRGRLPSALRSLANRAAIRPISTTLPRQKASPKDDEPVLNKVSRHITQPVSQGASQAMLYATGLTEADMNKAQVGISSVWYNGNPCNMHLLDLNNRVREGVQKAGLIGYQFNTIGVSDGISMGTSGMRYSLQSRDLIADSIETVMGGQWYDANISIPGCDKNMPGVLMAMGRVNRPSLMVYGGTIKPGCASMQGNADIDIVSAFQAYGQFISGEINEPQRFDIIRHACPGGGACGGMYTANTMATAIEVMGMTLTGSSSNPAESQAKYDECLRAGEAIKRLLVEDIRPSDIMTRQAFENAMVVVNITGGSTNAVLHLIAIADSVGIKLTIDDFQAVSDRTPFLADLKPSGKYVMADLHNIGGTPSLLKFLLKEGVIDGSGITVTGETLAKNLEKVPDFPEDQKIIRPFSNPIKETGHIQILRGSLAPGGCVGKITGKEGTVFTGKARVFNHEDDFIAALERKEITKDEQTVVVIRYTGPKGGPGMPEMLKPSSALMGAGLGQTCALITDGRFSGGSHGFLIGHIVPEAAVGGPIGLVHDGDVITIDAEKRVLDLDVDEAELAKRRKQWEADKAAGKLPQTGLNLRGTLGKYARNVKDASSGCITDAFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AZI6</accession>
    <accession>C8V198</accession>
    <name>Q5AZI6_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CENP-Q, a CENPA-CAD centromere complex subunit-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_06294</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF69763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_663898.1">
        <property type="nucleotide sequence ID" value="XM_658806.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AZI6"/>
    <dbReference type="STRING" id="227321.Q5AZI6"/>
    <dbReference type="GeneID" id="2870978"/>
    <dbReference type="KEGG" id="ani:ANIA_06294"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN6294"/>
    <dbReference type="eggNOG" id="ENOG502S7CP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058654_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AZI6"/>
    <dbReference type="OMA" id="QMKNEHP"/>
    <dbReference type="OrthoDB" id="2420947at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025212">
        <property type="entry name" value="CAD_CENP-Q"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13094">
        <property type="entry name" value="CENP-Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="137"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF69763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="257" mass="29332" checksum="73C736A509772591" modified="2005-04-26" version="1">MPAKRKHSGNALDQDNDSRRKRSYAYLKPQVRHISERTIKSKWSTLPEPMQDKIRDMLQALERPVIVRQQNERKRYEAQAAVQAVVKNLGKRLPRMPFPPMTKDSVFEYEAALKEHSALEASLSTMNDSIVLLNNEIAKEEAFLAKETKQLQEMEKNAKRAEAERRRLMKNEHPALRQLRDVREQQIEAPSGFNLSHAKGSQLDFSELEADPEASSLLKQLNNHLKSMQSNIAPLTGLKDAIDRSQTALSLATLPDD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-04-04" modified="2026-01-28" version="110" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AZY1</accession>
    <accession>C8V2A6</accession>
    <name>MRH4_EMENI</name>
    <protein>
        <recommendedName>
            <fullName>ATP-dependent RNA helicase mrh4, mitochondrial</fullName>
            <ecNumber>3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">mrh4</name>
        <name type="ORF">AN6149</name>
    </gene>
    <organism>
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">ATP-binding RNA helicase involved in mitochondrial RNA metabolism. Required for maintenance of mitochondrial DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text>The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DEAD box helicase family. MRH4 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13"/>
    <dbReference type="EMBL" id="AACD01000105">
        <property type="protein sequence ID" value="EAA57935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF70085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_663753.1">
        <property type="nucleotide sequence ID" value="XM_658661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AZY1"/>
    <dbReference type="SMR" id="Q5AZY1"/>
    <dbReference type="FunCoup" id="Q5AZY1">
        <property type="interactions" value="106"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5AZY1"/>
    <dbReference type="EnsemblFungi" id="CBF70085">
        <property type="protein sequence ID" value="CBF70085"/>
        <property type="gene ID" value="ANIA_06149"/>
    </dbReference>
    <dbReference type="GeneID" id="2871118"/>
    <dbReference type="KEGG" id="ani:ANIA_06149"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN6149"/>
    <dbReference type="eggNOG" id="KOG0335">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_18_0_1"/>
    <dbReference type="InParanoid" id="Q5AZY1"/>
    <dbReference type="OMA" id="HSTIDFI"/>
    <dbReference type="OrthoDB" id="10256233at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47960">
        <property type="entry name" value="DEAD-BOX ATP-DEPENDENT RNA HELICASE 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0347">Helicase</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0809">Transit peptide</keyword>
    <feature type="transit peptide" description="Mitochondrion" evidence="2">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000232353" description="ATP-dependent RNA helicase mrh4, mitochondrial">
        <location>
            <begin position="47"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="3">
        <location>
            <begin position="195"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="4">
        <location>
            <begin position="452"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="46"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="235"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif">
        <location>
            <begin position="167"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DEAD box">
        <location>
            <begin position="354"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="208"/>
            <end position="215"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="6"/>
    <sequence length="630" mass="70100" checksum="F403EFD7CDB26BAD" modified="2005-04-26" version="1" precursor="true">MNRLGGLSLPLRPVCLFCRAQTSLALSPLQGGQAVRSIATGRLRRRARMTLSKDVAKSSLKPKRTDRGKLGPFPNMNQTRARVREDPRSRSPAALKRSGETEEKPAMNTESPLYKALKMQTALAPISYGKRTAIKAKIAEITSFDAFTLLPIVRNSIFSQALPGIADAVPTPIQRVAIPRLLEDAPAKKQAKKVDDDEPQYEQYLLAAETGSGKTLAYLIPVIDAIKRQEIQEKEMEKKEEERKVREREENKKNQAFDLEPEIPPPSNAGRPRAIILVPTAELVAQVGAKLKAFAHTVKFRSGIISSNLTPRRIKSTLFNPAGIDILVSTPHLLASIAKTDPYVLSRVSHLVLDEADSLMDRSFLPISTEVISKAAPSLQKLIFCSATIPRSLDSQLRKLYPDIWRLTTPNLHAIPRRVQLGVVDIQKDPYRGNRNLACADVIWSIGKSGAGSDEAGSPWSEPKTKKILVFVNEREEADEVAQFLKSKGIDAHSFNRDSGTRKQEEILAEFTEPAAVPTAEEILLARKQQQRENINIPFVLPERTNRDTERRLDGVKVLVTTDIASRGIDTLALKTVILYHVPHTTIDFIHRLGRLGRMGKRGRAVVLVGKKDRKDVVKEVREVWFGLDS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-03-21" modified="2026-01-28" version="107" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B058</accession>
    <accession>C8V2T0</accession>
    <name>RMT2_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein arginine N-methyltransferase 2</fullName>
            <ecNumber evidence="1">2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Protein-arginine N5-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Type IV protein arginine N-methyltransferase</fullName>
            <shortName evidence="1">Type IV PRMT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rmt2</name>
        <name type="ORF">AN6072</name>
    </gene>
    <organism>
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">S-adenosyl-L-methionine-dependent protein-arginine N-methyltransferase that methylates the delta-nitrogen atom of arginine residues to form N5-methylarginine (type IV) in target proteins. Monomethylates ribosomal protein L12.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class I-like SAM-binding methyltransferase superfamily. RMT2 methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="AACD01000104">
        <property type="protein sequence ID" value="EAA58047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF70243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="ANIA_06072"/>
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    <dbReference type="KEGG" id="ani:ANIA_06072"/>
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    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS51559">
        <property type="entry name" value="SAM_RMT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000228975" description="Protein arginine N-methyltransferase 2">
        <location>
            <begin position="1"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="RMT2" evidence="2">
        <location>
            <begin position="207"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="65"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="73"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="155"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
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    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="263"/>
            <end position="268"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
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    <feature type="binding site" evidence="2">
        <location>
            <begin position="284"/>
            <end position="286"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="311"/>
            <end position="312"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="331"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
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        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="Q03305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="426" mass="47392" checksum="ECDE41561E5BB01A" modified="2005-04-26" version="1">MANPVTEIDVDLNTQEVLLAASQHDTAKLRRLLRANDAAGNPANVKDPETGYSPLHAAIAACEPDEEEDVKSNGVQTNGDRQTHGQESTVEAAVQTVKLLLQEGAIWNDLDLNNETPGCIARRLGLTELYDMVVDAGVRAELLLNRLDGYEQLSDEEMEEDGEQEQEQQDAAVAADASITNTAEDESVPQLVDTTAAAPPQTADAEPSVTSSRYLNSDLTFQQDRLLDQDQNGVMMAWESDIMAKSAKQLLPTPGLRVLNVGHGMGIVDGFIQEQSPSAHHIIEAHPAVVAEMKRKGWHEKPGVVIHEGKWQDILPGLVAEGVMFDAIYYDTFAESYADFREFFTEQVIGVLEQEGKWSFFNGMGADRQISYDVYQKVVEMDLFEAGFDVEWEEIDVPKLEGEWNGVRRPYWSIDKYRLPLCKYMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="131" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B0Y7</accession>
    <accession>C8VFD5</accession>
    <name>Q5B0Y7_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ANIA_05793</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the peptidase T1A family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_658305.2"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="227321.Q5B0Y7"/>
    <dbReference type="GeneID" id="2872084"/>
    <dbReference type="KEGG" id="ani:ANIA_05793"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN5793"/>
    <dbReference type="eggNOG" id="KOG0184">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035750_0_1_1"/>
    <dbReference type="InParanoid" id="Q5B0Y7"/>
    <dbReference type="OMA" id="RVSMYMH"/>
    <dbReference type="OrthoDB" id="40134at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
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        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0010499">
        <property type="term" value="P:proteasomal ubiquitin-independent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="entry name" value="proteasome_alpha_type_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000044">
        <property type="entry name" value="Probable proteasome subunit alpha type-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
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        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="1 2 3" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="5">
        <location>
            <begin position="8"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="247"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="254"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBF81179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="298" mass="31847" checksum="8FF4C98DFC3895C2" modified="2005-04-26" version="1">MTSIGTGYDLSNSVFSPDGRNFQVEYAVKAVENGGTSIGIRCKDGVVLAVEKIITSKLLKPGANKRISTVDRHVGIVSSGLAPDGRHFVSRARDEASSWRGIYKSPIPVSALANRLGGYVQAYTLYSSVRPFGVTSIVGGWDSEAELAVDGQVGSGPQSGSGGKVEGAKSGGPGLYMIEPSGLYWGYYGAATGKGRQAAKAELEKLDLASEKLSLQDAVKEAARIIYVAHEDNKDKEFELEMSWISSLNGPTKGRHEEVPKELLEEAERAAKRALEGDDEEEEDGSKATGNEGERMEE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-09-11" modified="2025-04-09" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B128</accession>
    <accession>C8VFI8</accession>
    <name>MED18_EMENI</name>
    <protein>
        <recommendedName>
            <fullName>Mediator of RNA polymerase II transcription subunit 18</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Mediator complex subunit 18</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">srb5</name>
        <name type="synonym">med18</name>
        <name type="ORF">AN5752</name>
    </gene>
    <organism>
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Mediator complex subunit 18 family.</text>
    </comment>
    <dbReference type="EMBL" id="AACD01000098">
        <property type="protein sequence ID" value="EAA62845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF81278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_663356.1">
        <property type="nucleotide sequence ID" value="XM_658264.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B128"/>
    <dbReference type="SMR" id="Q5B128"/>
    <dbReference type="STRING" id="227321.Q5B128"/>
    <dbReference type="EnsemblFungi" id="CBF81278">
        <property type="protein sequence ID" value="CBF81278"/>
        <property type="gene ID" value="ANIA_05752"/>
    </dbReference>
    <dbReference type="KEGG" id="ani:ANIA_05752"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN5752"/>
    <dbReference type="eggNOG" id="ENOG502S7EN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084516_0_0_1"/>
    <dbReference type="InParanoid" id="Q5B128"/>
    <dbReference type="OMA" id="PVHQHHE"/>
    <dbReference type="OrthoDB" id="5348092at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060261">
        <property type="term" value="P:positive regulation of transcription initiation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.320.10">
        <property type="entry name" value="Hypothetical Protein Pfu-838710-001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019095">
        <property type="entry name" value="Mediator_Med18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13321:SF2">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13321">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION, SUBUNIT 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09637">
        <property type="entry name" value="Med18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0010">Activator</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_0000304761" description="Mediator of RNA polymerase II transcription subunit 18">
        <location>
            <begin position="1"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="85"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="91"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="265" mass="29717" checksum="D0CEFADC9098BDB0" modified="2005-04-26" version="1">MHELLLFASVPSHQHHELLQQLTGLTAMQPRHCLERRLIFKATRKPDLANMRSGTGQGPDIVRLNKMLNGQMFYTQVVGPLSEADFDGKPSSSDSQDVSMSGTHEAAGSSYDYDSQPWRLEFRDTPEAGFRSTITARLAASAALPKGDVVPSMNAWGYSFVTEYVVEGDMFIYNDIVIFLHRVLQYPATGQEPHEPRRQLPSFRDLAPLEKTGSYILQAAITVQDGSNQELMRTASQHLFGLREQLKSAVRLEHADRLSLDTRAR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-08-16" modified="2026-01-28" version="104" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B1T9</accession>
    <accession>C8VGC6</accession>
    <name>ATG2_EMENI</name>
    <protein>
        <recommendedName>
            <fullName>Autophagy-related protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">atg2</name>
        <name type="ORF">AN5491</name>
    </gene>
    <organism>
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Lipid transfer protein required for autophagosome completion and peroxisome degradation. Tethers the edge of the isolation membrane (IM) to the endoplasmic reticulum (ER) and mediates direct lipid transfer from ER to IM for IM expansion. Atg2 binds to the ER exit site (ERES), which is the membrane source for autophagosome formation, using basic residues in its N-terminal region (NR) and to the expanding edge of the IM through its C-terminal region. The latter binding is assisted by an atg18-PtdIns3P interaction. Atg2 then extracts phospholipids from the membrane source using its NR and transfers them to atg9 to the IM through its predicted beta-sheet-rich structure for membrane expansion.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine(in) = a 1,2-diacyl-sn-glycero-3-phosphocholine(out)</text>
            <dbReference type="Rhea" id="RHEA:38571"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) = a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out)</text>
            <dbReference type="Rhea" id="RHEA:38663"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out)</text>
            <dbReference type="Rhea" id="RHEA:38895"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Preautophagosomal structure membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ATG2 family.</text>
    </comment>
    <comment type="sequence caution" evidence="4">
        <conflict type="erroneous gene model prediction">
            <sequence resource="EMBL-CDS" id="EAA62651" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EMBL" id="AACD01000094">
        <property type="protein sequence ID" value="EAA62651.1"/>
        <property type="status" value="ALT_SEQ"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF81808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B1T9"/>
    <dbReference type="STRING" id="227321.Q5B1T9"/>
    <dbReference type="EnsemblFungi" id="CBF81808">
        <property type="protein sequence ID" value="CBF81808"/>
        <property type="gene ID" value="ANIA_05491"/>
    </dbReference>
    <dbReference type="GeneID" id="2871780"/>
    <dbReference type="KEGG" id="ani:ANIA_05491"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN5491"/>
    <dbReference type="eggNOG" id="KOG2993">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000626_1_0_1"/>
    <dbReference type="InParanoid" id="Q5B1T9"/>
    <dbReference type="OMA" id="AVWKRAP"/>
    <dbReference type="OrthoDB" id="18982at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061908">
        <property type="term" value="C:phagophore"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043495">
        <property type="term" value="F:protein-membrane adaptor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061723">
        <property type="term" value="P:glycophagy"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000425">
        <property type="term" value="P:pexophagy"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026849">
        <property type="entry name" value="ATG2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13190">
        <property type="entry name" value="AUTOPHAGY-RELATED 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13190:SF1">
        <property type="entry name" value="AUTOPHAGY-RELATED 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13329">
        <property type="entry name" value="ATG2_CAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0072">Autophagy</keyword>
    <keyword id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword id="KW-0445">Lipid transport</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0653">Protein transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000215831" description="Autophagy-related protein 2">
        <location>
            <begin position="1"/>
            <end position="2090"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="284"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="355"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="395"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="463"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="568"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="652"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1967"/>
            <end position="1986"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="2071"/>
            <end position="2090"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="285"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="415"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="469"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="501"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="606"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="623"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="691"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="2078"/>
            <end position="2090"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="O94649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="P53855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="2090" mass="228397" checksum="2A8CE9A14128C9DE" modified="2011-11-16" version="2">MTYFLPSFFQKRLLKYALSRLEFIDTEALDPDSLGIRWGQRSTVELRDIGLRLEKLATLLHLPASSKLLAARIRLLRLTVPADIYSSGIICEASGIDVHLHFPSEKEASAARTSLFESHEFGHESIIPNPADLAESFLQAEPKEEKEELQAALSSRSEILHRTSSSISDDEEELGLGDETVSLPSFVAAFLKGVADRLQVHVDEVSIRLDVEMKQDGPSKRQPEEKPDLISGLLIIRQISVGAVVTASSSDELHPGKRPISLSAIELALVSEPIVFSNYSQFTAPTSPSSPLRSKSSQSSSPASSVPPAPSSASSSTHAMMASTIFEPSQPTVDIPEDEHGVAKLEGSIYTYDGRFSDADTDENRSHGYLEESQDLSEKLLDDPAYLDSVIDSHLQDDDSEGLGDIQPGDIKPGDSNQSYTDRSTPSQPSLGFQAPALVDPHSRSGDHSVAVASMPNIRNIERPLDQYGPQSSMPVLSRPLTQDITGNNSQESQPAPPSPSETSSSGSVSAYFNNDLSESRLFSPEEAQSMYMSAMSHRSDSRSFIPDIPGAWDSPEATLRREAIQHHGSLGHTDETTEALEDQDRTPVSTPKPTDRETKYHSGHTLGQQQESYSESTDKHSIQPSPDVNETTKVSKSFLHIDKVTIWIPSTKPTKDHQDISEPLDARSAGGSFKDSTTHLEASQVRERSVSFSKPPSSLRTRRDSTELALAGTDTKSYTKYGLGSLNSTNISVEISCIEVQFDISIGWLMIKIGQRVLQGFGDIGQPKTSKKSTERDVQSPQDIDFTLGTLCIKFVELVPGKSFPLEEQQDPSTTFFDLLHDSVLLQSTVSGVQAHYSNANNVTDFSAAVSKFTIKFATEDLISFSEDMKMRESTKDGLLPTGNDIVLSLSKSQDSATFKTDTLPLCVSLNIQRLEDLLGRFGGLSTIMELGSSISSMSGSKGPKNDVPRRTRGVRFAGSPQSPVRSPTPSVPWKVNARIGGIVLDVSGENHYLTLRTTAAKIISRYEMMAVQIDKAKLSGPLSIHSGKDAPAKVSLNNIRVEFLYTPKEPDLDRLLSLITPSKDKYDDDDDIMIDTLFRQRKQGSVLRVTVSGAKVVVSRPELGPLQQLGEELGRLSSVAKYLPEDDRPGILTLVLIRDVEARVHIGGQIGTIAANLENAEAAHISIPSLVAGQLGSIRVTRNGDEELIGEALPPKPGFAPLPVLMVRFIADEMEPTIRVKLHNLRVEYTVSAAMAFLGVSDEMTPGDVAANMASSLANIAELHPPLQDLEEGSTTPVKPMKLKVSMRDCVLGLNPRGTAAKGLIVLANSTFNGAIHDISSSEIALDLRKAFVMIIDDVRNTDARGNLPRRRAASPQSDQIQAFTDMGYVSVSSISSATAVVRIMRLTENGAKSLDVEVRDDLLILETCADSTQTLISILSGLQPPSPPSQLKKYRTEVVPIRDMLDSLSGDAFAADNLPIGAADQAEIQDHIPERDIDYVTDFHSMTASEEELASGPSSQVRDSFHSQCHVSSSMSELDFREDHFMQQSSVGGTAHRWDSTHNTYDLSDDSKLQNSPLRVRVRDAHVIWNLFDGYDWQRTRDTISKAVKDVEKKATDRRTSGRATAAFEDDEEAIIGDCLFNSVYIGIPANRDPAELRNDINRNIDDLISETGSYATTSTVTTARRNMSPGFRGKKLRLSRSKDHKMTFELKGICADLVVFPPGSQETMSSLDVRVKELEIFDHIPTSTWRKFATYMNEAGEKELGTSMVHLEILTVRPVSYLAASELILKATVLPLRLHVDQDALDFMSRFFEFRDDSTAPSGPSQEPPYLQRSEINAIPVKLDFKPKRVDYAGLRSGRTTEFMNFFILDEADMVLKHVIVYGAKGFDKLGQALNDVWMPDIKNNQLPGVLAGLAPIRSLVNVGSGVKDLVAVPVREYRKDGRIVRSIQKGAFAFAKTTSNELVKLGAKLAIGTQTVLQGAEELLSPPTGQATTGEEDEIDEDEAPKKISLYADQPVGVVQGLRGGFRGLERDLLLTRDAIIAVPGEVQESGSAKAAAKAVLKRAPTVILRPAIGVSKAVGQTLLGAGNSMDPSNRRKIEDKYKRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B293</accession>
    <accession>C8VGT9</accession>
    <name>Q5B293_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ANIA_05337</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF82076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_662941.1">
        <property type="nucleotide sequence ID" value="XM_657849.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B293"/>
    <dbReference type="STRING" id="227321.Q5B293"/>
    <dbReference type="GeneID" id="2871630"/>
    <dbReference type="KEGG" id="ani:ANIA_05337"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN5337"/>
    <dbReference type="eggNOG" id="KOG2688">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017745_0_0_1"/>
    <dbReference type="InParanoid" id="Q5B293"/>
    <dbReference type="OMA" id="IPCNIIM"/>
    <dbReference type="OrthoDB" id="5404651at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045114">
        <property type="entry name" value="Csn12-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12732:SF8">
        <property type="entry name" value="NUCLEAR MRNA EXPORT PROTEIN THP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12732">
        <property type="entry name" value="UNCHARACTERIZED PROTEASOME COMPONENT REGION PCI-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00753">
        <property type="entry name" value="PAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF82076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="628" mass="69755" checksum="64C2A4B55D583424" modified="2005-04-26" version="1">MAFQGTPVLDRFLTSLAEIVRDRDGAKLQDFLQIEPPLPDVYRQMVDELRQHYANGSTKEAELLRRCEGLVPKSKGSSAWTAFPTFMKLYFCFLRDVNVDNLLETYDMLKMLLNQCVMALGDSQFGIVVLPTVLYLSKVLAKLAMGLDRRPELIAHLLRLEGGADQDESTEKVTLVEKSANVVREAFIKCLTDRSGTPGVHGKPEGKRVGIYLMANLCLKLLFQCGKLRNAEQMFASISAQSPPLKHFPASQRVTYLYYLGRYLFSNNLFFPAQIALQSAYDQCHRQAINQKRLILTYLITCNIIMGRFPSLQLLQRPEAEGLADKFLPVCQLIVRGDYIAFRDHLTVNSPATEWFARKGILLPLRNRCEILVWRSLARKVFIHGGFHGDPQGQAQRGPPPFLYLTKLEAAVRWLQAQHPTSHPMPTTSAFGNNLPLAASKSQSGSQIVAIAPDPDFDCLDGPDTNGTALNSSLLSKYEDYLCPDGFFDETGQWQSNPTKALVDGTPDSDYSKYELNPYAEPTDEGDKPSPLMREIESILASLLTQGLMRGYLTHRNPRFAIPGARLRGALPTGFPNVWKTIYARESEDTGVPGWVQPPPTTTMGVAAALGGGGRVVNLSGVRPVGVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B2J2</accession>
    <accession>C8VFB6</accession>
    <name>Q5B2J2_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_05238</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF81144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_662842.1">
        <property type="nucleotide sequence ID" value="XM_657750.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B2J2"/>
    <dbReference type="GeneID" id="2871529"/>
    <dbReference type="KEGG" id="ani:ANIA_05238"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN5238"/>
    <dbReference type="eggNOG" id="ENOG502QUY7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038374_6_0_1"/>
    <dbReference type="InParanoid" id="Q5B2J2"/>
    <dbReference type="OMA" id="NDIVWED"/>
    <dbReference type="OrthoDB" id="5392716at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025676">
        <property type="entry name" value="Clr5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058913">
        <property type="entry name" value="Integrase_dom_put"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46791:SF5">
        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46791">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14420">
        <property type="entry name" value="Clr5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24764">
        <property type="entry name" value="rva_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Clr5" evidence="1">
        <location>
            <begin position="7"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase core" evidence="2">
        <location>
            <begin position="161"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF81144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="477" mass="55488" checksum="A493075350D92592" modified="2005-04-26" version="1">MPRPSINLEPYKDEISTLYKSGKSPPTIAMLLGNRYDIQVSERTIKTRLSIWGIHKTNRTASKDTVLHARIKVLLYQVGLSENEILHVLQLEGWNIQPRTLKYVRHQKGLLLRTVNPIADQAEVERVLNQLRTDLATGQIEGYSIGMLIGTLRTKDFRLADGYLKLAPYGIEIYAAIDAYSRYIIWIYVGISSRTAVSVLRQFLDTVNIAQQQPRFVRTDRGTETVLLAEAQYKLQQSLHPEIDIRDCYLYGTSTSNQRIEAWWLQLTRGMVFRYREYFRGLQEEGIFSIDQLSDQIALYAIYIPLLRVQIPSFVRTWNHHRIRNQPNRPHLVPGKPYMNYNFPATGVENQGIKFDMELFKRLQEDVQDWDIDEYLPPETYHWTRNQLLELGYDPQQPPEAVGDHILTPFRTIYLGLRARIQAHIERGAQPILQISQPPTGAFDWDPRLNPHGTEALERVREVEVEYELDESEELED</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="113" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B2S1</accession>
    <accession>C8VF29</accession>
    <name>Q5B2S1_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Putative phospholipase</fullName>
            <ecNumber evidence="4">3.1.1.47</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ANIA_05159</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphocholine + acetate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17777"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:30909"/>
            <dbReference type="ChEBI" id="CHEBI:36707"/>
            <dbReference type="EC" id="3.1.1.47"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the serine esterase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.47" evidence="4"/>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF80984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_662763.1">
        <property type="nucleotide sequence ID" value="XM_657671.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B2S1"/>
    <dbReference type="STRING" id="227321.Q5B2S1"/>
    <dbReference type="ESTHER" id="emeni-q5b2s1">
        <property type="family name" value="PAF-Acetylhydrolase"/>
    </dbReference>
    <dbReference type="GeneID" id="2871451"/>
    <dbReference type="KEGG" id="ani:ANIA_05159"/>
    <dbReference type="eggNOG" id="KOG3847">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022501_3_0_1"/>
    <dbReference type="InParanoid" id="Q5B2S1"/>
    <dbReference type="OMA" id="EAPCDGR"/>
    <dbReference type="OrthoDB" id="2363873at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003847">
        <property type="term" value="F:1-alkyl-2-acetylglycerophosphocholine esterase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000594">
        <property type="entry name" value="Putative phospholipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016715">
        <property type="entry name" value="PAF_acetylhydro_eukaryote"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10272:SF11">
        <property type="entry name" value="PHOSPHOLIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10272">
        <property type="entry name" value="PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03403">
        <property type="entry name" value="PAF-AH_p_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018169">
        <property type="entry name" value="PAF_acetylhydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 4" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="3 4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="226"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="547"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="551"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="346"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="377"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR018169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR018169-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBF80984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="580" mass="63445" checksum="E2482E6207723AFC" modified="2005-04-26" version="1">MSHDVFLARCPGIWQLILIEPSGWIQVNQINDVTSSHMQPSKDGQDGRPSLPFETSSLKYSGPYRVGAIDIEAPCDGRIVHPSIHLSDGQAAFQLDTVLFTLYYPAAPDAVATRSRHPWLIEPIRLRGEGFARFVNASNWLVDRVFAFMLWALAGSVRIPADVDIPLRDPSSADKLGESPTDTHHRYPVIVFSHGVAASRTDYTQLCGELASRGYVVAALEHRDGSGPGSVVRRGGGRKGTVVASDGSPTGQGHGQARPGARRLRSVLHFAAKHLHHDPPLDEAELQRAQLSFRQAEMEEVVRVLRMLNAGDGQTVFRHNARREGVYLAGWKGRLDIERVILVGHSYGATGVLQACRPTADLSQALPIPLAGCIALDPGKASGPLNDDIGVPLLVIHSHSWSRKFSLFMGRPHFEVVRDLVRTCLQRTGAAWFMTSLGTSHASCTDAPVLQPLLLNWATGAAVDAHEGVLLYVRRIQEFIEFVNTGKREGLLDQQETHASYDEGTLVPWTKVYGPRHWTRDWQIHVAPAVESENVAERVKRKLGALDEGANESSEGLESGETLVGCGGQVDTRSSRVVMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="100" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B2V4</accession>
    <accession>C8VEY8</accession>
    <name>Q5B2V4_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Microtubule binding protein HOOK3, putative (AFU_orthologue AFUA_1G07490)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_05126</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF80909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_662730.1">
        <property type="nucleotide sequence ID" value="XM_657638.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B2V4"/>
    <dbReference type="STRING" id="227321.Q5B2V4"/>
    <dbReference type="GeneID" id="2871417"/>
    <dbReference type="KEGG" id="ani:ANIA_05126"/>
    <dbReference type="eggNOG" id="ENOG502QQM8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013811_0_0_1"/>
    <dbReference type="InParanoid" id="Q5B2V4"/>
    <dbReference type="OMA" id="DAKYRKC"/>
    <dbReference type="OrthoDB" id="2129491at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030705">
        <property type="term" value="P:cytoskeleton-dependent intracellular transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd22211">
        <property type="entry name" value="HkD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18947:SF28">
        <property type="entry name" value="GIRDIN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18947">
        <property type="entry name" value="HOOK PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116907">
        <property type="entry name" value="Hook domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="395"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="441"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="146"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="503"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="402"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF80909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="638" mass="73020" checksum="ACC22BCDC61B6A54" modified="2005-04-26" version="1">MESERTVSHSEALLAWVNSFDLVGEPKQIAELSDGRIIWDILHDIDPERFPDVTDPKKSNLENLVTIHGRLQYNILDLRKSEGWPRGLDPEPNLIEFAENNSARDAEKLLKLVFFAATITAKGNTASYETYGDAIQKLDSPIQESLQDFLENVEEGQYELDDLARESRESQLVKTIEELKQENTVLREKYVKTEQRVLELEYAEENYKSELEFMKERIEVLKSGKGEFGFSKRDLDQKTEEIAALEEQLFIASEQNGKLSSRIDELLREAKDYQAVRDKLDIEKNNYANANRNAKFAAEQKSKEIEMLQTKNQNLEAEKKELKKQVLEYDVQVQRLNDQLRESNNALARSEREAREMSITKGNVDLDNEELRRRLEGAEKEIHDLKGRIGELEGIDDEYSGTPRSRTPTTGVLTPGIQGNLQKDLEAAGFEESTLSIGEEEHTDFTSRVEEGPGEELNKENDEQQLAMKEEDKAKLLQEMLKPLEEAKEQLAQFISQQTGAGSEAIQQSLEELTKQISDLIEKDHERLAQRAQYIHQQNEQIKVLRERISELETVVEEANAAEREEDTVSKERERALEKQLDALTRELALMSSAWYELQSKLHSTNNVPTSRYRHGSAGLVDAQKSWLARQRSAVAGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="102" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B4C8</accession>
    <accession>C8V7T7</accession>
    <name>Q5B4C8_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Prefoldin subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ANIA_04602</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 4">Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the prefoldin subunit alpha family.</text>
    </comment>
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        <property type="protein sequence ID" value="CBF77169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_657114.1"/>
    </dbReference>
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        <property type="interactions" value="943"/>
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    <dbReference type="STRING" id="227321.Q5B4C8"/>
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    <dbReference type="KEGG" id="ani:ANIA_04602"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN4602"/>
    <dbReference type="eggNOG" id="KOG3313">
        <property type="taxonomic scope" value="Eukaryota"/>
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        <property type="component" value="Chromosome III"/>
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    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0000318"/>
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    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd23156">
        <property type="entry name" value="Prefoldin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.370:FF:000001">
        <property type="entry name" value="Prefoldin subunit 3"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Prefoldin"/>
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        <property type="entry name" value="Prefoldin_subunit_alpha"/>
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        <property type="entry name" value="PREFOLDIN SUBUNIT 3"/>
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        <property type="entry name" value="PREFOLDIN SUBUNIT 3"/>
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        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Prefoldin_subunit_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="135"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR016396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBF77169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="193" mass="21843" checksum="B6FC6B4FDBF875E5" modified="2005-04-26" version="1">MADKKPSDPTQTNPRGIPVAPFVDNVSDYVSSRADVEPTMRSFQEMISKYQFMEVNTSRRAAGLREKIPDIKKTLEMVTFLKARKESSSATPLETNFELNDTLYARATVDPAHTEEVYLWLGANVMLAYPIAEAQAMLEDKLAAAEQSLANCDEDLEFLREQITTLEVATARVYNWDVVQRRKERAEGKEETS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="112" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B4T1</accession>
    <accession>C8V8J1</accession>
    <name>Q5B4T1_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Proteasome component Pup3, putative (AFU_orthologue AFUA_4G07420)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ANIA_04449</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="5">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="CBF77496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_662053.1">
        <property type="nucleotide sequence ID" value="XM_656961.1"/>
    </dbReference>
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    <dbReference type="FunCoup" id="Q5B4T1">
        <property type="interactions" value="1071"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5B4T1"/>
    <dbReference type="MEROPS" id="T01.P02"/>
    <dbReference type="GeneID" id="2872243"/>
    <dbReference type="KEGG" id="ani:ANIA_04449"/>
    <dbReference type="eggNOG" id="KOG0180">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_035750_10_0_1"/>
    <dbReference type="InParanoid" id="Q5B4T1"/>
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        <property type="component" value="Chromosome III"/>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
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        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="P:proteasomal ubiquitin-independent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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        <property type="entry name" value="proteasome_beta_type_3"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Proteasome subunit beta type-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Ntn_hydrolases_N"/>
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        <property type="entry name" value="Proteasome_beta_3"/>
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    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
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    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF10">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA TYPE-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3 6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBF77496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="192" mass="21108" checksum="4B5462BA517CB2C1" modified="2005-04-26" version="1">MVGKDCVAIACDLRLGMQALTVSNNFPKIFNYAPGTYLGLTGLATDVSTVSDLFRLKVNMYRLREERHIAPQTLANLVSSTLYERRFGAYFVSPVIAGINNTTGKPFICGFDSIGCIDFAKDFIVSGTASDQLFGTCEGLWEPDMSPEDLFETISQALLSAVDRDALSGWGAQVYIIEKDKVTQRLLKGRQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="107" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B541</accession>
    <accession>C8V950</accession>
    <name>Q5B541_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_04339</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF77728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_661943.1">
        <property type="nucleotide sequence ID" value="XM_656851.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B541"/>
    <dbReference type="STRING" id="227321.Q5B541"/>
    <dbReference type="GeneID" id="2872141"/>
    <dbReference type="KEGG" id="ani:ANIA_04339"/>
    <dbReference type="eggNOG" id="KOG1840">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_125_13_1"/>
    <dbReference type="InParanoid" id="Q5B541"/>
    <dbReference type="OMA" id="QHPETWI"/>
    <dbReference type="OrthoDB" id="5986190at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040586">
        <property type="entry name" value="FxSxx_TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF10">
        <property type="entry name" value="NB-ARC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="895"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="65"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF77728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="1146" mass="128623" checksum="91EF7A98FFC26751" modified="2005-04-26" version="1">MSVARRAGPIKSRSPFVLTPKSFLVFLPLTGLPKLQNGLQGLLPCLFSSDTFGILETTIVRRRAPSAANSAPTVTNGSRQGASGAPLDKPAYPHSAPETGYLRPDTFLRTLVPGKSPKIDIVAIHGLNPKNKERHAERTWELNGKIWLRDFLPSQLPQARIMIYGYNSNVSIQSSSAGVREQAQNLLNRLWLERQSWWYSGQGAFFGTPHRGSQLAKLGETVAKAVRAFLRTPNNTFINALKENDLYANELSANFSQLLEDYKYINFYETLPLRSLGIIVEKKSATLGLPDSREITVALLGDHESICRFASEEDDNYKHVSGLITRFAAIAMRECEEASLFGELGTESTLAGLSLVDQLGSRTCMIPFPRNQAFVGRASILEQVKSQILPIGTTSRLVLFGLGGVGTRKSHIAIEFAHQIYTELQASVFWVSASSIDRFREGYSAIFDEHISDSDVKCDKAVRVKEWLEKEHDEWVLIIDNADETSLFEPSKHGKQSESQSILEFIPESQRGVILVTTRNRAAGVKFTKGAAKALIEVKPMTSEEAKLLIKSNVTEQILEEDELDRLSEILGHLPLAIVQAAAFMQENSMSVSEYIELYNDSEETSMDLLCEPFETLGRDTGVPNAVATTLIVSLDQIKERDPKAVEILQLIPFLDRNEVPKSLVQHRIKRPLELTKALGTLKAFSLIVPTNGKGDFSFHRLVQLVLRKWLILESLYEEKSVHAMELLDELYPDATFENWGTCAAYLPHAQSVLSLVSEAHDESRKKRIHLQEGIAYYLWSQGYYQEAEKLDALIVEEKKREFGPEHPETLESMTGLAATYHDQARWAEAEQLDSFVLEARRKMLGSSDRLTLTTMANLATTYVSQDRMQEAESLRREVYETSKSEFGEEDEDTIIAMTNLGTLYIDLGKVEEAAGLIQRALAWRTKSQGPEHKDTLVCSSTLAKVYKAQGKLEEAEELALQCLTVSEAVLGPQHPETWIRKTIVADIYLERGKLDMAEEQFVQMIEKMEQEKAPRYDILEKILRLAGVYRAKGDEKMVVKLEGEALDGSIQELGPDHPFTMRCLYFVAVTHKQYGRDAEAIRLMTLATHREEKVLGPYHDSTLESFHMLREWCGDDVAIQKLLEIDERGESKPSGWRGRSTVGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B5P9</accession>
    <accession>C8V500</accession>
    <name>Q5B5P9_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sodium ion/proton exchanger (Eurofung)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ANIA_04131</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF74637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_661735.1">
        <property type="nucleotide sequence ID" value="XM_656643.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B5P9"/>
    <dbReference type="GeneID" id="2873552"/>
    <dbReference type="KEGG" id="ani:ANIA_04131"/>
    <dbReference type="eggNOG" id="KOG4505">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008635_5_1_1"/>
    <dbReference type="InParanoid" id="Q5B5P9"/>
    <dbReference type="OMA" id="FINSERW"/>
    <dbReference type="OrthoDB" id="5327978at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015385">
        <property type="term" value="F:sodium:proton antiporter activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120029">
        <property type="term" value="P:proton export across plasma membrane"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0042391">
        <property type="term" value="P:regulation of membrane potential"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036376">
        <property type="term" value="P:sodium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004712">
        <property type="entry name" value="Na+/H+_antiporter_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31382">
        <property type="entry name" value="NA(+)/H(+) ANTIPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31382:SF3">
        <property type="entry name" value="SODIUM ION_PROTON EXCHANGER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="112"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="258"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="350"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="379"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="414"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="6">
        <location>
            <begin position="46"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBF74637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="698" mass="76130" checksum="C4A3EF9F5567913B" modified="2005-04-26" version="1">MPTLVVRAFIILYALASVKIKNHWYLGEARRSSSAHSSPTPNSGATVPALLIGIVLGPYAARFLDASEWGSAVWGQQDAITLGLCRVVIGVQLVIVGFQLPAKYQIHRWKEMLICLMPNMALMWLCTSACILLAIPRLNLSPADVQGQLSALVLGSCVTSTDPILSQAIAKGPFADRYVARDLREIISSEAGANDGFGFPFLMLATYLLRYTQGDPAHNPDQDEIEHRSISLYTRAGQVGHQDGGLTKAMEMWVVETWCYYVVMGAVYGAVVGYAGMHALRFALRRKWVDGESYLLFPAALGLFTIGTCGVIGTNDLLACFSAGTALNWDGAYLSETEARHDEVNPSIDVLLNFAGFMYIGAVIPWADFHQPETTGITYPRLILLGFMVLLFRRIPSLLVLWKLMPKVCTSWKEALFMGYFGPIGIGGIFYAEHASHLFPEDGEGSAVETTLIRALKPIIHGLSIPVLSIAYKILNVPHQIDPLGPAEVRPLSRNAHLPPNSTVNTKQHSILMYNRFSRSKFPGAGVGMGWGLPHFQSVEERDREESKKRGLWGDSFYLTTGSEDSEGSGHGPVGEKGWGLGGGAIGGKRFEIRPAHVVPSVAYRGIAFKQFFELNVTSGKSMAKNMFTVFQSRKSMYENPGTKVKEHDLQQGPGNTPPARHLHLATNANATAGESQLIHSYASRAPPTATDQATHAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B613</accession>
    <accession>C8V5P9</accession>
    <name>Q5B613_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein YIP</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ANIA_04017</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Golgi apparatus membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the YIP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF74877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_661621.1">
        <property type="nucleotide sequence ID" value="XM_656529.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B613"/>
    <dbReference type="FunCoup" id="Q5B613">
        <property type="interactions" value="295"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5B613"/>
    <dbReference type="GeneID" id="2873440"/>
    <dbReference type="KEGG" id="ani:ANIA_04017"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN4017"/>
    <dbReference type="eggNOG" id="KOG3114">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059606_2_1_1"/>
    <dbReference type="InParanoid" id="Q5B613"/>
    <dbReference type="OMA" id="VFRRCVA"/>
    <dbReference type="OrthoDB" id="10256463at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006977">
        <property type="entry name" value="Yip1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039765">
        <property type="entry name" value="Yip5/YIPF1/YIPF2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12822">
        <property type="entry name" value="PROTEIN YIPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12822:SF2">
        <property type="entry name" value="PROTEIN YIPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04893">
        <property type="entry name" value="Yip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="248"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="Yip1" evidence="8">
        <location>
            <begin position="101"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="34"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="276"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="278"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBF74877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="301" mass="33500" checksum="C858D68B0B34192C" modified="2005-04-26" version="1">MSNQGYDVVVDVDAEGDDLGHTDLQEDLEFHPSNFENDQRNAKSHPDNAAFLGSGGGSSSRRNRSPGGTPTKHAWWSIHYYEQYFDVDTNEVLRRCVASVYPRSNFLDVLEGNADLYGPFWIATTVIVILFLTGTISQWLSNNDKEHFKYDFTLLSGAAGLVYGYTFALPIALWGALKWFGSSTADLVECWALYGYSNLVWIAVALVSWSPLTALNWALVGVGFAWTVFFLLRNLYPVLSATDAKASRALLILVIVLHAGFAIAIKILFFAHGSPVSKKGDSEKGRDDDKDDHDDHDKRMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="129" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B6J0</accession>
    <accession>C8V6J3</accession>
    <name>Q5B6J0_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 21">Folylpolyglutamate synthase</fullName>
            <ecNumber evidence="6 21">6.3.2.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19 21">Folylpoly-gamma-glutamate synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18 21">Tetrahydrofolylpolyglutamate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">ANIA_03840</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="25" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="25">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="21">Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20 21">
            <text>(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + L-glutamate + ATP = (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n+1) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10580"/>
            <dbReference type="Rhea" id="RHEA-COMP:14738"/>
            <dbReference type="Rhea" id="RHEA-COMP:14740"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:141005"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="21">
            <name>a monovalent cation</name>
            <dbReference type="ChEBI" id="CHEBI:60242"/>
        </cofactor>
        <text evidence="21">A monovalent cation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 21">Cofactor biosynthesis; tetrahydrofolylpolyglutamate biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 21">Belongs to the folylpolyglutamate synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.17" evidence="6 21"/>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF75265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_661444.1">
        <property type="nucleotide sequence ID" value="XM_656352.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B6J0"/>
    <dbReference type="FunCoup" id="Q5B6J0">
        <property type="interactions" value="652"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5B6J0"/>
    <dbReference type="GeneID" id="2873263"/>
    <dbReference type="KEGG" id="ani:ANIA_03840"/>
    <dbReference type="eggNOG" id="KOG2525">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015869_0_1_1"/>
    <dbReference type="InParanoid" id="Q5B6J0"/>
    <dbReference type="OMA" id="THALFCT"/>
    <dbReference type="OrthoDB" id="5212574at2759"/>
    <dbReference type="UniPathway" id="UPA00850"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:metal ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:tetrahydrofolylpolyglutamate synthase activity"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046901">
        <property type="term" value="P:tetrahydrofolylpolyglutamate biosynthetic process"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1190.10:FF:000009">
        <property type="entry name" value="Folylpolyglutamate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.20:FF:000009">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="entry name" value="Mur ligase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="entry name" value="Mur-like, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001645">
        <property type="entry name" value="Folylpolyglutamate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018109">
        <property type="entry name" value="Folylpolyglutamate_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023600">
        <property type="entry name" value="Folylpolyglutamate_synth_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01499">
        <property type="entry name" value="folC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136:SF5">
        <property type="entry name" value="FOLYLPOLYGLUTAMATE SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136">
        <property type="entry name" value="FOLYLPOLYGLUTAMATE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038895">
        <property type="entry name" value="FPGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="MurD-like peptide ligases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="MurD-like peptide ligases, peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01011">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01012">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 22" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 21" id="KW-0436">Ligase</keyword>
    <keyword evidence="15 23" id="KW-0460">Magnesium</keyword>
    <keyword evidence="17" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 23" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12 22" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 21" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="23">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
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    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <position position="206"/>
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        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="327"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="341"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00047493"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PIRSR" id="PIRSR038895-1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR038895-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="CBF75265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="517" mass="57174" checksum="843FC4B0A31F5D4D" modified="2005-04-26" version="1">MSRDYKAAISALNSLQSNFAIVKEFNKPETRHALNLRSLPETVEWLRRIGYQPSDLNRLNPIHVAGTKGKGSTSSFISSILYQFTPSQSSSPVFNKVGLYTSPHLRFARERIRINNEPLSEELFAQYFFEVWDRLDDAARAAGEDPNNLQTKPQYFRYLTLMAFHTYLSEGVDAAVIECGIGGEYDCTNVIEQPAATAITSLGIDHVALLGNTIEEIAWHKGGIIKANTKAFSAPQPPSAEKVLRERAANKHTELEFVSSHPDLKKNGDIKLGLAGDFQYGNAALAVATAGEVLKKVGKLDISAGFREQSLPAEFRKGLEQAQLEGRCQTRKEENVIWYIDGGHTQESIKLAGQWFASQIKADSSSEASAAKKLRVLIFNQQTRDSNALAQSLHETLESALGSKTPFTHAIFCTNVTYKETGYRPDLVSMNQDGAAVEKLQVQKALAEKWNSIDPSAEVKVFATIEEAIDFTRDLASREENRIEGDETPIMTFVTGSLHLVGGVLDVIETKPYSKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B6Q0</accession>
    <accession>C8V713</accession>
    <name>Q5B6Q0_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Rhamnosidase B, putative (AFU_orthologue AFUA_7G05040)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_03780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF75400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_661384.1">
        <property type="nucleotide sequence ID" value="XM_656292.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B6Q0"/>
    <dbReference type="CAZy" id="GH78">
        <property type="family name" value="Glycoside Hydrolase Family 78"/>
    </dbReference>
    <dbReference type="GeneID" id="2873197"/>
    <dbReference type="KEGG" id="ani:ANIA_03780"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN3780"/>
    <dbReference type="eggNOG" id="ENOG502QVPG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009782_0_0_1"/>
    <dbReference type="InParanoid" id="Q5B6Q0"/>
    <dbReference type="OMA" id="NCRHETY"/>
    <dbReference type="OrthoDB" id="6503935at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.420.10">
        <property type="entry name" value="Maltose phosphorylase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035396">
        <property type="entry name" value="Bac_rhamnosid6H"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34987:SF2">
        <property type="entry name" value="B, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G05040)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34987">
        <property type="entry name" value="C, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G02880)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17389">
        <property type="entry name" value="Bac_rhamnosid6H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-L-rhamnosidase six-hairpin glycosidase" evidence="1">
        <location>
            <begin position="389"/>
            <end position="716"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF75400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="836" mass="93455" checksum="76BAE13816A4988D" modified="2005-04-26" version="1">MPPWTSTTPWLWLPESTPAFTSTHSTARIVLFPRSIPVHVSADTRYILFINGKRILFGPAKSYLHEYNYETIDIAPFLVPGQKNVLAAKVLRYSPVKEGNMGMVRAGIGGFILHESSGLLGVSTTEDSGWKCLPDDSVRILSSSEWNRALGPAFMQINEEVDGSLAVEGWLDGDFDDSAWLGAERSSLKTPMLPILEPWRLVPRSIPLFPETEGRFSAIIKPNSEQPGLDLAGSWRSLLRNDGSGIVEIPPNTRTAVILENESLITAFLELRFRGGAGSTVTVRCAECFEYPPPEGNLNPFARNKGDRADTSGILVGPEDSYTVSSSSTTEQEWMYEPFWFRTFRYVQLTVSTHSQPLQITRLTYRRTHYPLPINTSLSNMPLVESKKWAISLNTLLNCMQETYTDCPFYEQNQFAFDSRLQMLYSYQLSSDDRLARKTINEFHASRRGSDGLVETHFPTPFPGVTIPIFSLSWVLMLWDHIMYTVDTEASKRFVKRYLGGIDSVLNYFDSRISNAYSGMIGRFGDADSPNDEIWAFVDWTAEWSVLGPGGDFKHLAVPPAYRRTGVASYNSLFYAYVLNKAAEVCEFVGRLGLAEEYRSRAESVNEAVRRHCLRTDEDGKEILVDGPDSPTTERSQHVAVFAVLSGAFTGSRARALLCRALHPDTRGGYVKASYAQSFYLLEAAVQVGLYDELRGTLVQPWTEMVDLNLTTWAESSAMPRSDCHGWSCVPIYDIVANVIGLRPAAPGYRRVRFEPRLQLWEGGGEGVITVGIGGNGDKREVRVEWEKEGRVLLTVGSDCEVEVPTASDGSGEGDEKTYRVKKMKKGETLILTLYR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2010-06-15" modified="2026-01-28" version="108" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B6Q3</accession>
    <accession>C8V716</accession>
    <accession>Q1HFT3</accession>
    <name>EXGB_EMENI</name>
    <protein>
        <recommendedName>
            <fullName>Glucan endo-1,6-beta-glucosidase B</fullName>
            <ecNumber>3.2.1.75</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Beta-1,6-glucanase B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Endo-1,6-beta-D-glucanase B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Endo-1,6-beta-glucanase B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">exgB</name>
        <name type="ORF">AN3777</name>
    </gene>
    <organism>
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="11417" last="11422">
            <title>Development and application of a suite of polysaccharide-degrading enzymes for analyzing plant cell walls.</title>
            <authorList>
                <person name="Bauer S."/>
                <person name="Vasu P."/>
                <person name="Persson S."/>
                <person name="Mort A.J."/>
                <person name="Somerville C.R."/>
            </authorList>
            <dbReference type="PubMed" id="16844780"/>
            <dbReference type="DOI" id="10.1073/pnas.0604632103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA]</scope>
        <scope>FUNCTION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Participates in the metabolism of beta-glucan, the main structural component of the cell wall. Acts on lutean, pustulan and 1,6-oligo-beta-D-glucosides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>Random hydrolysis of (1-&gt;6)-linkages in (1-&gt;6)-beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.75"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.75"/>
    <dbReference type="EMBL" id="DQ490491">
        <property type="protein sequence ID" value="ABF50867.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AACD01000061">
        <property type="protein sequence ID" value="EAA59985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF75405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_661381.1">
        <property type="nucleotide sequence ID" value="XM_656289.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B6Q3"/>
    <dbReference type="SMR" id="Q5B6Q3"/>
    <dbReference type="CAZy" id="GH5">
        <property type="family name" value="Glycoside Hydrolase Family 5"/>
    </dbReference>
    <dbReference type="GlyCosmos" id="Q5B6Q3">
        <property type="glycosylation" value="1 site, No reported glycans"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CBF75405">
        <property type="protein sequence ID" value="CBF75405"/>
        <property type="gene ID" value="ANIA_03777"/>
    </dbReference>
    <dbReference type="KEGG" id="ani:ANIA_03777"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN3777"/>
    <dbReference type="eggNOG" id="ENOG502RBRB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004624_7_0_1"/>
    <dbReference type="InParanoid" id="Q5B6Q3"/>
    <dbReference type="OMA" id="WMLPAEW"/>
    <dbReference type="OrthoDB" id="1887033at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046557">
        <property type="term" value="F:glucan endo-1,6-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004338">
        <property type="term" value="F:glucan exo-1,3-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000269">
        <property type="entry name" value="Probable glucan endo-1,6-beta-glucosidase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050386">
        <property type="entry name" value="Glycosyl_hydrolase_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297">
        <property type="entry name" value="GLUCAN ENDO-1,6-BETA-GLUCOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297:SF39">
        <property type="entry name" value="GLUCAN ENDO-1,6-BETA-GLUCOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0326">Glycosidase</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0624">Polysaccharide degradation</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000394710" description="Glucan endo-1,6-beta-glucosidase B">
        <location>
            <begin position="17"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="228"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="330"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="4">
        <location>
            <position position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="O85465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="3">
        <source>
            <dbReference type="UniProtKB" id="P29717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="4"/>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="16844780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="6"/>
    <sequence length="409" mass="46267" checksum="83704098EDC15087" modified="2005-04-26" version="1" precursor="true">MKFILPLFTSLPVALAWLPGIDKDIYSAAGTNIFNVTSASSKRWLPASKKIRGVNLGSHFVIEPWMASMAWSNMGCSGQRSEFDCVMALGQETADQAFADHWGSWITQDDINQMVQYGLNTIRIPVGYWLKEDLVYADSEHFPKGGIGYLEDVCGWASDAGMYIIIDLHGAPGAQQPKQPFTGQYAPNPGFYQDYQYDRALEFLEWMTTSIHQNNKFRNVGMLEIVNEPVQNADQASSMINSYYPSAFTRIRNTESSLGITSNNYLHIQMMNEKWGSGDPTQSLTDNYFAAYDDHRYVKWDSSVAVDKESYISASCVDDRGGNWPTIVGEWSLSVPDNVEHTADWEPSSNTDFYARWFAAQAIAYEKQEGWVFWSWKAQLGDYRWSYKDAVDAGVIPKDLDSIYDYSPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="105" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B7E9</accession>
    <accession>C8V4S9</accession>
    <name>Q5B7E9_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">GMC oxidoreductase (AFU_orthologue AFUA_2G01770)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ANIA_03531</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF75954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_661135.1">
        <property type="nucleotide sequence ID" value="XM_656043.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B7E9"/>
    <dbReference type="CAZy" id="AA3">
        <property type="family name" value="Auxiliary Activities 3"/>
    </dbReference>
    <dbReference type="GeneID" id="2872949"/>
    <dbReference type="KEGG" id="ani:ANIA_03531"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN3531"/>
    <dbReference type="eggNOG" id="KOG1238">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002865_6_3_1"/>
    <dbReference type="InParanoid" id="Q5B7E9"/>
    <dbReference type="OMA" id="SDHMIFF"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF123">
        <property type="entry name" value="GMC OXIDOREDUCTASE (AFU_ORTHOLOGUE AFUA_2G01770)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="5">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="6">
        <location>
            <begin position="265"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="499"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="537"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBF75954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="555" mass="59538" checksum="A68D904D13672B3B" modified="2005-04-26" version="1">MSEIHYDYIIIGGGLAGCTLAGRLAEKNRSLQILIIEAGPNVAGHTLTEYPLACFGAHFSPLDWAYTTVPQTHLDNRMCYNSAAKALGGGSAINYGTWTRGNAADYDRWAAMVDDESWGYEALLPYFKRMENCLDCKGTETGAHGVSGPIHNVSVSGGSADRIYPLREPLRRAWERLGVKEVLDANAGSPLGLGELVENWREGRRQITADVFNILERPGITTLTETMVQKILIEKDQQGKKVAKGVQVVQGPVFLADREVIVSAGAYRTPQILMLSGIGPKDELAKLGIAAVADAPGVGQNLHDHFAFVQWWRLRHPEKGLSIGTPLWDSLAYGMGLPCDWIATLQAPRNELVQALHQDGATDVGSHPYLAPDACHVETLIVYAPAGAAVSRIEIPMDGTHIASAVLGMATTSRGRITLASADATTAPLIDPNYYATEFDRAVLRAGIRQVGKLLLETPEGKETVEAEAPHPGFQALGVEPTDVEIDARVKAGGNTFYHPGGTAAMGKVVDTSLRVIGVEGLRVVDASVLPLPVTAHYQALVYAIADKAADLILS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2018-05-23" modified="2025-04-09" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B7I8</accession>
    <accession>A0A1U8QIT7</accession>
    <accession>C8V549</accession>
    <name>SCPR_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">C2H2-type zinc-finger transcription factor</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Fellutamide B biosynthesis cluster protein F</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Inp $cluster regulator scpR</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Secondary metabolism cross-pathway regulator</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">scpR</name>
        <name type="ORF">AN3492</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2010" name="Appl. Environ. Microbiol." volume="76" first="8143" last="8149">
            <title>Activation of a silent fungal polyketide biosynthesis pathway through regulatory cross talk with a cryptic nonribosomal peptide synthetase gene cluster.</title>
            <authorList>
                <person name="Bergmann S."/>
                <person name="Funk A.N."/>
                <person name="Scherlach K."/>
                <person name="Schroeckh V."/>
                <person name="Shelest E."/>
                <person name="Horn U."/>
                <person name="Hertweck C."/>
                <person name="Brakhage A.A."/>
            </authorList>
            <dbReference type="PubMed" id="20952652"/>
            <dbReference type="DOI" id="10.1128/AEM.00683-10"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2016" name="ACS Chem. Biol." volume="11" first="2275" last="2284">
            <title>Resistance gene-guided genome mining: serial promoter exchanges in Aspergillus nidulans reveal the biosynthetic pathway for fellutamide B, a proteasome inhibitor.</title>
            <authorList>
                <person name="Yeh H.H."/>
                <person name="Ahuja M."/>
                <person name="Chiang Y.M."/>
                <person name="Oakley C.E."/>
                <person name="Moore S."/>
                <person name="Yoon O."/>
                <person name="Hajovsky H."/>
                <person name="Bok J.W."/>
                <person name="Keller N.P."/>
                <person name="Wang C.C."/>
                <person name="Oakley B.R."/>
            </authorList>
            <dbReference type="PubMed" id="27294372"/>
            <dbReference type="DOI" id="10.1021/acschembio.6b00213"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="3 4">C2H2-type zinc-finger transcription factor that controls the expression of the nonribosomal peptide synthases inpA and inpB, as well as of the other inp cluster-associated genes (PubMed:20952652, PubMed:27294372). Also mediates the expression of the asperfuranone biosynthesis gene cluster by binding to the afoA promoter (PubMed:20952652). Probably recognizes the 5'-CT/C/AAAAGGAT/AT/GG/CA-3' motif in the promoters of teget genes (PubMed:20952652).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the GLI C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF76044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AACD01000059">
        <property type="protein sequence ID" value="EAA59053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_661096.1">
        <property type="nucleotide sequence ID" value="XM_656004.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B7I8"/>
    <dbReference type="SMR" id="Q5B7I8"/>
    <dbReference type="STRING" id="227321.Q5B7I8"/>
    <dbReference type="EnsemblFungi" id="CBF76044">
        <property type="protein sequence ID" value="CBF76044"/>
        <property type="gene ID" value="ANIA_03492"/>
    </dbReference>
    <dbReference type="KEGG" id="ani:ANIA_03492"/>
    <dbReference type="HOGENOM" id="CLU_1004825_0_0_1"/>
    <dbReference type="InParanoid" id="Q5B7I8"/>
    <dbReference type="OMA" id="TARNFHR"/>
    <dbReference type="OrthoDB" id="5366256at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0810">Translation regulation</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <keyword id="KW-0863">Zinc-finger</keyword>
    <feature type="chain" id="PRO_0000444107" description="C2H2-type zinc-finger transcription factor">
        <location>
            <begin position="1"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C2H2-type; degenerate" evidence="1">
        <location>
            <begin position="185"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="23"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="78"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="20952652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="27294372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="5">
        <source>
            <dbReference type="PubMed" id="20952652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="6"/>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBF76044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="277" mass="30569" checksum="F095A780CE9A7C2E" modified="2005-04-26" version="1">MNTMNNMHLYADSLGIHPADHYPTMNEIETTDNTYPRYTSPPHPSILHHPQAPEPAPPRAQTAHPPAWALTSQSGYQMNEPSLSLTPEHRPAAGPPNGPNLNHDSDPRRPARRQQPCGVGTTRPLPGCPGQGQEPSRRRTTFTDSISNPDSTIRCWDHGCEGRKFSSVGNYRRHLREKNGQAKMHPCPDCGRVFTRSTARNFHRQSGTCGLIPSQLMLQMGMGMQLQVQMQPVSQHSLASGHPPAFNLAPPVLLEPLADWSEPSQMDLYAASGVVFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B7K3</accession>
    <accession>C8V564</accession>
    <name>Q5B7K3_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PRISE-like Rossmann-fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_03477</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF76074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_661081.1">
        <property type="nucleotide sequence ID" value="XM_655989.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B7K3"/>
    <dbReference type="GeneID" id="2872901"/>
    <dbReference type="KEGG" id="ani:ANIA_03477"/>
    <dbReference type="HOGENOM" id="CLU_088631_0_0_1"/>
    <dbReference type="InParanoid" id="Q5B7K3"/>
    <dbReference type="OMA" id="INIGMTH"/>
    <dbReference type="OrthoDB" id="1731983at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NAD-DEPENDENT EPIMERASE_DEHYDRATASE DOMAIN-CONTAINING PROTEIN"/>
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        <property type="entry name" value="PRISE"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRISE-like Rossmann-fold" evidence="1">
        <location>
            <begin position="79"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22917"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="CBF76074.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="274" mass="31862" checksum="C2512861913CD710" modified="2005-04-26" version="1">MKEACPKTLLKILEEPAVEIHWLKVRISAHMENSRIPLTRFEDGPQVDEGVDFGRLAVMHQRLYIWSRARFLVVSVLGQMQQKVPNVKDVTHVYYLAYSKATAYSLDVMAIRDINIGMTHNAVHAVDQLCRILKFFVLQIGTNQKIYGVALLRFQEYIEIYPPLREDNLRIPSPWGDEIFYYGQIDLIQEANKGKSWKWRRPYPDEHDIYLMLYRYFNGPGATAVFIGSYINYIHTYTSSSQDIIARSELYLSLKKPDQAHDEAFNIADKSTHL</sequence>
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<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B813</accession>
    <accession>C8VHY2</accession>
    <name>Q5B813_EMENI</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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        <name evidence="1" type="ORF">ANIA_03317</name>
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        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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            <taxon>Aspergillus subgen. Nidulantes</taxon>
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        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
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            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
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            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
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        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF82967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_655829.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="ani:ANIA_03317"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN3317"/>
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    <dbReference type="InParanoid" id="Q5B813"/>
    <dbReference type="OrthoDB" id="4510631at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF82967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="129" mass="14768" checksum="9A1D016568E07CAE" modified="2005-04-26" version="1">MAWNKLEGGLRVHIPDPAPRTIIAEFLDQLDAKYGIWKDMTRDRGHIGQIKRATKRPASPISKHGPPGRLLLDLYIHMHRTKLPRDLSATKLALNDIPAKQFYKRGKESLLPTVNMVSEARQKCDEFEM</sequence>
</entry>
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    <accession>Q5B8K9</accession>
    <accession>C8VIJ9</accession>
    <name>Q5B8K9_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conserved glutamic acid-rich protein (AFU_orthologue AFUA_3G12790)</fullName>
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    <gene>
        <name evidence="2" type="ORF">ANIA_03121</name>
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        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
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                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
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            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF83369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_655633.1"/>
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    <dbReference type="GeneID" id="2874171"/>
    <dbReference type="KEGG" id="ani:ANIA_03121"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN3121"/>
    <dbReference type="eggNOG" id="ENOG502SXT0">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="InParanoid" id="Q5B8K9"/>
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        <property type="component" value="Chromosome VI"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="10"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="81"/>
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    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF83369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="156" mass="16697" checksum="EAE1B217C7516936" modified="2005-04-26" version="1">MSTRKRKQELEEEEELQALPSDESEEEEEYESTEGEGEGESEGSEEEEDLSEEEPEEEEEPEEQGPPASKKRKTAAAPKADDEDEDAVEEEAEANGKAGGDENGLDNDEGEDEEDAEAEGEEDEEADETAKTSAPAAKVKGDAAAAAEGATAETKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="105" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B8T1</accession>
    <accession>C8VIS4</accession>
    <name>Q5B8T1_EMENI</name>
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        <recommendedName>
            <fullName evidence="4 10">Mannan endo-1,6-alpha-mannosidase</fullName>
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    </protein>
    <gene>
        <name evidence="13" type="ORF">ANIA_03049</name>
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    <organism evidence="13 14">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
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        <lineage>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Random hydrolysis of (1-&gt;6)-alpha-D-mannosidic linkages in unbranched (1-&gt;6)-mannans.</text>
            <dbReference type="EC" id="3.2.1.101"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyl hydrolase 76 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.101" evidence="4 10"/>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF83502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_660653.1">
        <property type="nucleotide sequence ID" value="XM_655561.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B8T1"/>
    <dbReference type="STRING" id="227321.Q5B8T1"/>
    <dbReference type="CAZy" id="GH76">
        <property type="family name" value="Glycoside Hydrolase Family 76"/>
    </dbReference>
    <dbReference type="GeneID" id="2873925"/>
    <dbReference type="KEGG" id="ani:ANIA_03049"/>
    <dbReference type="eggNOG" id="ENOG502QSWP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025694_1_1_1"/>
    <dbReference type="InParanoid" id="Q5B8T1"/>
    <dbReference type="OMA" id="ACDGGMR"/>
    <dbReference type="OrthoDB" id="4187847at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008496">
        <property type="term" value="F:mannan endo-1,6-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000006">
        <property type="entry name" value="Mannan endo-1,6-alpha-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005198">
        <property type="entry name" value="Glyco_hydro_76"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014480">
        <property type="entry name" value="Mannan-1_6-alpha_mannosidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12145:SF35">
        <property type="entry name" value="MANNAN ENDO-1,6-ALPHA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12145">
        <property type="entry name" value="MANNAN ENDO-1,6-ALPHA-MANNOSIDASE DCW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03663">
        <property type="entry name" value="Glyco_hydro_76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016302">
        <property type="entry name" value="Man_a_manosd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010295879" description="Mannan endo-1,6-alpha-mannosidase" evidence="12">
        <location>
            <begin position="26"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="475"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR016302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CBF83502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="499" mass="55462" checksum="FD7133B1332B465C" modified="2005-04-26" version="1">MRWGTLRSLAGSALAVLLLGQLVVADIPIEVSSTGIPHPNSYLAPTQLYPALPSSTQLHPALTQLLPSSYYRVASTVLPPDLAGKEIAAPMMTFYAQNQTEGIPGKLTDTWYVAGAMFMTLIQYWQASGDDQYNSIVSHDLMFQAGRNYDFFDSNYSRWLGNDDQMFWGLAAITASETGFPEIENKPTWTTLARAVFNMQANRWDMSACNGGINWQIHAWQKGNKLRNSISNGGLFQLAARLGRFTENSTYFEFAEKIWDWSVDSPLITPDQDWFVADSTTGQSNCTESGNMQWSYNYGSYLAGCAFMYNATGDEKWLRATTGLLARLETTFFPAEYDHSVMSEVSCEKLHTCDRNMLCFKGWTAMWMALTANLVPQTRATIVPKLQGSAAAIGRQCDGESENLCGSRWYQDTWDGIKGLEVQMAALGGITSNLMLMTEATAKTINTNPDAKEQHLETHDDDPAILRTITTGDRVGSWILTAAWSIGILSAAWWLVRQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BA10</accession>
    <accession>C8VHS9</accession>
    <name>Q5BA10_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cytochrome b561 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_02620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF84351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_660224.1">
        <property type="nucleotide sequence ID" value="XM_655132.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BA10"/>
    <dbReference type="STRING" id="227321.Q5BA10"/>
    <dbReference type="GeneID" id="2874258"/>
    <dbReference type="KEGG" id="ani:ANIA_02620"/>
    <dbReference type="eggNOG" id="ENOG502SQWM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_299566_0_0_1"/>
    <dbReference type="InParanoid" id="Q5BA10"/>
    <dbReference type="OrthoDB" id="19261at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="CDD" id="cd09630">
        <property type="entry name" value="CDH_like_cytochrome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08760">
        <property type="entry name" value="Cyt_b561_FRRS1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1210">
        <property type="entry name" value="Cellobiose dehydrogenase, cytochrome domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015920">
        <property type="entry name" value="Cellobiose_DH-like_cyt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47797:SF3">
        <property type="entry name" value="CYTOCHROME B561 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47797">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05805)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49344">
        <property type="entry name" value="CBD9-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="380"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="416"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="606"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="810"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="844"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="871"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="895"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="921"/>
            <end position="939"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF84351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1001" mass="111961" checksum="66E2E53F69F09FD6" modified="2005-04-26" version="1">MYRTEQSISWELVVSRLPGRLLVTTALNICCSFSSNCTRSGQLLEHEVRDWLDENSTVDLAEQDYGQVRLLMTSPASHDGRAKYPEGNFEDVFGGVINKPATDGLGLEDETIQYLSKLLNLPWPLSILTGYSSGIFTKFGHENGAGGLDGEGIFSILARAGMVIQTPHSTPIKCLLALFHDIENNLTTCFLHSAFPAHLFHFRDLVPKLLAKSNRPMNVFPVVFLKMYNECIEGYQKIQEGNIVFLEEAIGQTDYYQYKPSSARMPRDMIKTINGISYDLSRFEQFIDFECRLHGFLIDLSNSSRSEFELSRDPNNSRKLAEWLQFIGCVALGHKQAVSSYRQRVQAQNMVLYSMVSQAESRLNYQVAASTKQDSSDMRAVALLTMLFLPGTFIASFFSAGLVATNPGSTPTTNKYLWIYWVITVPLTIIVILIWKCWSRKQAGGTNNLLWSIESSDPRYSPKITDSQLKIILPTPVTGHLKRSGITISRLQSLQPRGPLYGRGQARNCYCTRASRFLPASVRIILARAAFDSIMRQLTEIFLRTVIAIVPLASWVAGEPVQYCRFGHEDKPDATVDFCLGITTYYNASSESHDMYRCMRVTRSSVLGWTAVGTGSVMAGSLMFIIYGDPFSSEHAAPTVSLRTIDGHHQPKLVSQADMEGADLRLLQPDWVSVNSTETDDERLDSKRDSVSVAKVAIMCYSCGKWHGAPISADAAAQPWIWAWNNFQEFDSYCCNSAKFNWVMNYTEDVHLKMHEHHAEDGGWGRFYVDMARSTSKDNSAPSIPPIRPGITALGVSDIPGGWSWLNPTVHIHGFLMSAAFLILYPAGLVAMWSGSSMSFKYHWIIQLLASLFVLIGGAIGLIRAHKIDSFHHFIGLTGVVCTTSMGFSRWLGRIFLLLGWTNVITGLLLTGHGWSLVPLAASFISVIALALVAWVWYATHQCKQREIRPDWEGEDSPFSLQPTRDDYFAVAADDDDEHDLRFSSDHSTPVKIRKEDADLR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2017-02-15" modified="2026-01-28" version="148" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BA83</accession>
    <accession>C8VPT1</accession>
    <name>EASB_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Highly reducing polyketide synthase easB</fullName>
            <shortName evidence="8">HR-PKS easB</shortName>
            <ecNumber evidence="9">2.3.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Emericellamide biosynthesis protein B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">easB</name>
        <name type="ORF">AN2547</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2008" name="Chem. Biol." volume="15" first="527" last="532">
            <title>Molecular genetic mining of the Aspergillus secondary metabolome: discovery of the emericellamide biosynthetic pathway.</title>
            <authorList>
                <person name="Chiang Y.M."/>
                <person name="Szewczyk E."/>
                <person name="Nayak T."/>
                <person name="Davidson A.D."/>
                <person name="Sanchez J.F."/>
                <person name="Lo H.C."/>
                <person name="Ho W.Y."/>
                <person name="Simityan H."/>
                <person name="Kuo E."/>
                <person name="Praseuth A."/>
                <person name="Watanabe K."/>
                <person name="Oakley B.R."/>
                <person name="Wang C.C."/>
            </authorList>
            <dbReference type="PubMed" id="18559263"/>
            <dbReference type="DOI" id="10.1016/j.chembiol.2008.05.010"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DOMAIN</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Polyketide synthase; part of the gene cluster that mediates the biosynthesis of emericellamides, secondary metabolites acting as antibiotics (PubMed:18559263). The biosynthesis of emericellamides initiates from the highly reducing polyketide synthase easB which catalyzes the formation of the linear polyketide chain (PubMed:18559263). EasB produces several polyketides that can be further processed by the downstream enzymes (PubMed:18559263). The polyketides are released from easB as linear polyketide carboxylic acids, which are converted to CoA thioesters by the acyl-CoA ligase easD (PubMed:18559263). The substrates are then loaded onto the acyltransferase easC, which shuttles them to the first thiolation (T) domain of the nonribosomal peptide synthetase easA (PubMed:18559263). EasA then performs condensation of the polyketides with one glycine, two alanine, one valine and one leucine residues (PubMed:18559263). A last step of cyclization leads to the production of emericellamides (PubMed:18559263).</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Antibiotic biosynthesis.</text>
    </comment>
    <comment type="domain">
        <text evidence="9">Multidomain protein; including a ketosynthase (KS) that catalyzes repeated decarboxylative condensation to elongate the polyketide backbone; a malonyl-CoA:ACP transacylase (MAT) that selects and transfers the extender unit malonyl-CoA; a dehydratase (DH) domain that reduces hydroxyl groups to enoyl groups; a methyltransferase (CMeT) domain responsible for the incorporation of methyl groups; an enoylreductase (ER) domain that reduces enoyl groups to alkyl group; a ketoreductase (KR) domain that catalyzes beta-ketoreduction steps; and an acyl-carrier protein (ACP) that serves as the tether of the growing and completed polyketide via its phosphopantetheinyl arm.</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="6">Impairs the production of emerecellamide A, C, D, E and F (PubMed:18559263).</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="9"/>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF87072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AACD01000043">
        <property type="protein sequence ID" value="EAA64652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_660151.1">
        <property type="nucleotide sequence ID" value="XM_655059.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BA83"/>
    <dbReference type="SMR" id="Q5BA83"/>
    <dbReference type="STRING" id="227321.Q5BA83"/>
    <dbReference type="EnsemblFungi" id="CBF87072">
        <property type="protein sequence ID" value="CBF87072"/>
        <property type="gene ID" value="ANIA_02547"/>
    </dbReference>
    <dbReference type="KEGG" id="ani:ANIA_02547"/>
    <dbReference type="eggNOG" id="KOG1202">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_31_1_1"/>
    <dbReference type="InParanoid" id="Q5BA83"/>
    <dbReference type="OMA" id="RNWIGAY"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900617">
        <property type="term" value="P:emericellamide A biosynthetic process"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900557">
        <property type="term" value="P:emericellamide biosynthetic process"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05195">
        <property type="entry name" value="enoyl_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000209">
        <property type="entry name" value="Polyketide synthase Pks12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050444">
        <property type="entry name" value="Polyketide_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45681:SF6">
        <property type="entry name" value="POLYKETIDE SYNTHASE 37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45681">
        <property type="entry name" value="POLYKETIDE SYNTHASE 44-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23297">
        <property type="entry name" value="ACP_SdgA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0012">Acyltransferase</keyword>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-0511">Multifunctional enzyme</keyword>
    <keyword id="KW-0521">NADP</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-0596">Phosphopantetheine</keyword>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000438970" description="Highly reducing polyketide synthase easB">
        <location>
            <begin position="1"/>
            <end position="2534"/>
        </location>
    </feature>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="3 9">
        <location>
            <begin position="49"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="4">
        <location>
            <begin position="973"/>
            <end position="1277"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="2 9">
        <location>
            <begin position="2452"/>
            <end position="2529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Malonyl-CoA:ACP transacylase (MAT) domain" evidence="1 9">
        <location>
            <begin position="587"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="region of interest" description="Dehydratase (DH) domain" evidence="1 9">
        <location>
            <begin position="973"/>
            <end position="1273"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="4">
        <location>
            <begin position="973"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="4">
        <location>
            <begin position="1131"/>
            <end position="1277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Methyltransferase (CMet) domain" evidence="1 9">
        <location>
            <begin position="1395"/>
            <end position="1625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Enoyl reductase (ER) domain" evidence="1 9">
        <location>
            <begin position="1834"/>
            <end position="2146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Ketoreductase (KR) domain" evidence="1 9">
        <location>
            <begin position="2453"/>
            <end position="2526"/>
        </location>
    </feature>
    <feature type="active site" description="For beta-ketoacyl synthase activity" evidence="3">
        <location>
            <position position="222"/>
        </location>
    </feature>
    <feature type="active site" description="For beta-ketoacyl synthase activity" evidence="3">
        <location>
            <position position="356"/>
        </location>
    </feature>
    <feature type="active site" description="For beta-ketoacyl synthase activity" evidence="3">
        <location>
            <position position="396"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="4">
        <location>
            <position position="1005"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="4">
        <location>
            <position position="1193"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="2">
        <location>
            <position position="2489"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="6">
        <source>
            <dbReference type="PubMed" id="18559263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="7">
        <source>
            <dbReference type="PubMed" id="18559263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="8"/>
    <evidence type="ECO:0000305" key="9">
        <source>
            <dbReference type="PubMed" id="18559263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAA64652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000005890"/>
        </source>
    </evidence>
    <sequence length="2534" mass="278404" checksum="0BA63D1B4782F280" modified="2005-04-26" version="1">MSPASRSRVEIADSESDSERLSSSPWSILSDNDSNTSDERSTRAGPGSLEPIAVIGIGCRLSGSATDVSGLWDMLKSGRSGWTPGPGTRFNMKAFQDPTGTRSGTTNATGGHFIREDISKFDATFFGINPVEAQAMDPQQRLMLEVAYEAFENAGITMDALWGSNTGVYVGQWASDYHEIATRDIERPPLYLVTGTGPAITSNRVSYVFNLRGPSFTVDTGCSSSLVALHQAVLSLRNRETTQCFVGGVNLLLDPQRFHYQSRLKMFSKDGRSFPFDARANGYGRGEGVTGVVLKPLSVALRDGDPVRAVIRNSVLNQDGRTPGISVPSAVAQKEAIIRAYRQAKLDLYADYVEAHGTGTKVGDPIETSAIAAALTQRRSPSRPLPIGSIKGNIGHTESAAGLAGLIKSVLMLENGMIPPQVNYETTNPDIHLEEWNLRIPTKLERQTLRRISLNSFGYGGTNAHVIIDAAHEAISAFGRLSLSRHLQLSYHSEKPRVFMVSGASEKACQRVCARLARYLVVNHRNSINPDALLARLAHTLAKQSIHAYRVIFVASELDELIKQLITASHSTITRREKFGQHRIALIFSGQGAQYAEMGRDLLKSYPSFVRSLERARQQLSRLGCTWDLLSELCRPKADSRVNEPAFSQPMCTAIQLALVDLLNEFGVSPSAVLGHSSGEIGAAYAAGALSFRDAISVSYYRGKLASELLAENQSPGAMIAVGAPPDIAEQHINKLGTDVGRMRIACFNSPSSVTVSGDVAAIDRIKEVLDTEGLFNRKLITHGAAYHSHQMKLIEDKYIAALKGLKAKPVSSSIRMFSSVTSKELDESTVLDGGYWAQNLVSPVLFSQALRTMCEQDYNGLPIDTLIEVGPHSQLSGPVNQILKTIPGPHGQASYTNTLKRGDDAETALLRCLGFLAIKNGSVRLCDLNKDSKDSDIQPLADLPPYSFDHDRSFWHETRLSRDYRHREHLPHELLGTLSADVNKLEPRWRRFVSLKETPWLRNHIIQGLITFPAAGYITMAIQAIRQHMHTANPASTIQFIRLRDVSFGKGLVLPDENAEVEISLSLRPQARTARESSGIWNEFRIFTVTPDQKWTEHCRGLVQAEVDSVEGFRSIFTPADISRIDSECTHGTIPQKFYAVGKRNGLDWQHPFNNLHQIRSSKHSCVATARVPEYEMPSGGMEDLLHPAVLDSALFHGLSTVIYLEDGRSSAYVPTFIKQLWVANRHVAPGSYLTCSTIRRNEPLVFDLHTKDEINQMAVVAQGIRVTSLGGDVAAGVSKREACHTQTLVPYVDAWTTEHRDQVCRATIELGSLMETNRALDAITIHFAQNAIREISLNDIQETHLQRYFQWMGTLADETYDNILLENKPEDLGVIGEAIAILGPHLVDILKGKTSALSLLTKNNLLSRVYTEWCSSRLYPQMSAYCHELGRFNPQLKVLEIGAGTGSATLPILKALNDCSGRFIQRYDFTDISPGFFEPAKERLGDLANVVEFRVLDAGRNAQEQGFEEGAYDLIVACNVIHATPRIDETLRNIRPLLKPGGKFMLMEISRYTLYFNIVFGLFEGWWLGYDEGRTRSPLLTDSEWCQRLEKAGFAHIEKAFVDYPHENGGSLSVFISTAPFPRRNESLPIHLLTDSNASNATEEQAQEIQQACQTSVALLPITHPCQHGGVAILLPEIAKLLCAEPDVNVWNSFKNWILKSRAVLLVSNCTMADSSHAETGLWAGFARTMRLEYPNLRQVVLDIQTPNVPVMSKLKEVLPIILNSSSFDLDCLSSEVENEFTEKDGQLFVSRYAYRPDISRDVDLTSRQAASEPVPFVSTGRILTAELGVPGLLETIRWKDDIECPPLGPDDVRFELRGASINFKDVLIAAGQLEGITEMRNDCSGVVVEVGENMKHRFKPGDRVCALYSRSYTNYPLVHGDCCQVIPDSLSFAEGASLPIVWATVYYGLVDKGSLSKGEKILIHSAAGAVGQAAIMLAQHLGAEVFATVGSEAKRDLLHAKYGVPYDHIFSSRTTAFYGEIMKSTGGYGVDVVLNSLSGEMFRESCNLMASFGRFVEIGRKDLMDDALMPMEFLLRNITFSYVDLTAIIEQRKPLARRLLHDIADLAASGSIRPVTLTTMPISDIEIAFRQIQAGKHTGKIVLTVEENQEVPAVPSMPKQARLHEDASYIVVGGLGGLGRWLTTWLADHGAKHIVALSRSGAKDADSRTFISNIRGRGVNLIAPPCDVVCADAVVALAQELKRSELPPVRGVINSAMVLRDTLFDNMTEDDWRTALASKVRGSQNLHTTFKSLDFFVMMSSIVAVRGNYGQSNYSAACSFQDTFVRHMVQQGEPAFSINIGPIRDVGYVSENPEVAEALRRNGLGSIGVSDVLIVLNHAILNARGANPSTCVASIGLIASDDESENGRDFLMTDRRFSQLVKHNGSKQKSAGEALDAITLLSAATQLDEAVHIVTNAILNQLSKLIVTPVEMLSPAQSLDSYGVDSLVAVELRNWIGAYLHANVQLMVIRGTGSISQLAAIVAKESRVVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BC64</accession>
    <accession>C8VKG5</accession>
    <name>Q5BC64_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_01866</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
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                <person name="Cornell M.J."/>
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    </evidence>
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        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
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            <authorList>
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                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
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            <dbReference type="DOI" id="10.1038/nature04341"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
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    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
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                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
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            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
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        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
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        <location>
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    </feature>
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        <source>
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        <source>
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        <source>
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        <source>
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    <reference evidence="3" key="1">
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            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
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                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
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                <person name="Asai K."/>
                <person name="Machida M."/>
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                <person name="Denning D.W."/>
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                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
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            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
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                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
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        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
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    <dbReference type="eggNOG" id="ENOG502QQ65">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_1261493_0_0_1"/>
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    <dbReference type="OMA" id="GQHNDHE"/>
    <dbReference type="OrthoDB" id="5346604at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="41"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="125"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="193"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF85520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="219" mass="21715" checksum="874DD74FF2C182BD" modified="2005-04-26" version="1">MPGVPPDALEQLKKGFKAIFRRKKKAQADPATGEPADKPVEAPAAAPAAAAPAAAPATEAKPAEPAATEPAPAAEPKTAETPATDKPAETPAQTETSAPAPAPAEASTAAPEKKPEETATESKTETPAATAAAAGAPAPTAPVENSESEPSVPPDSTVPQTPFETSAEKPAESAELAKPAEEKAAEPAKPADEAAPTAPAAEPAKSESLTPTGPYSCSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BCJ6</accession>
    <accession>C8VP35</accession>
    <name>Q5BCJ6_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">3-dehydroshikimate dehydratase, putative (AFU_orthologue AFUA_6G08740)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_01734</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF85460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_659338.1">
        <property type="nucleotide sequence ID" value="XM_654246.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BCJ6"/>
    <dbReference type="STRING" id="227321.Q5BCJ6"/>
    <dbReference type="GeneID" id="2874600"/>
    <dbReference type="KEGG" id="ani:ANIA_01734"/>
    <dbReference type="eggNOG" id="ENOG502QW0W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035063_0_2_1"/>
    <dbReference type="InParanoid" id="Q5BCJ6"/>
    <dbReference type="OMA" id="LLATHNM"/>
    <dbReference type="OrthoDB" id="5360893at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.150">
        <property type="entry name" value="Divalent-metal-dependent TIM barrel enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050312">
        <property type="entry name" value="IolE/XylAMocC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12110:SF56">
        <property type="entry name" value="DEHYDRATASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G08740)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12110">
        <property type="entry name" value="HYDROXYPYRUVATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="Xylose isomerase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylose isomerase-like TIM barrel" evidence="2">
        <location>
            <begin position="35"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF85460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="354" mass="38806" checksum="272352C2B8A8D193" modified="2005-04-26" version="1">MSSKASTSIPLSYATVSLGPPSTTSTIPLPQKLSALHLAGFNGIELGFPDLLAYASLRIAAAEVKKLCIAHSLEILMLQPFSNFEGWPRGSKEREDAFERAKGWISIMEACGTSMLQVGSSDTPLEKMAPSESRPDPEQGRGPRAYIVADLRELADLLGAKGFRLAYENWCWSSHAPNWKDVWDIVRAVDRDNIGLCLDTFQSAGGEWGDPTTSSGRIEDTVTNEKELSQRFEASMAELAATIPPEKIYLLQISDAYIPLDGEGRPRPLEKGVVDGTAPRGRWSHDYRPMPYDGGYLPIEAVGNAVLKTGFRGWFSVEIFDGGADGRGKEYELKEFAGRAKDAVEKFIERCLPA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-03-03" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BDG8</accession>
    <accession>C8VM25</accession>
    <name>LMBD1_EMENI</name>
    <protein>
        <recommendedName>
            <fullName>Probable lysosomal cobalamin transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ORF">AN1412</name>
    </gene>
    <organism>
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Probable lysosomal cobalamin transporter. Required to export cobalamin from lysosomes allowing its conversion to cofactors.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lysosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the LIMR family. LMBRD1 subfamily.</text>
    </comment>
    <comment type="sequence caution" evidence="4">
        <conflict type="erroneous gene model prediction">
            <sequence resource="EMBL-CDS" id="CBF84806" version="1"/>
        </conflict>
    </comment>
    <comment type="sequence caution" evidence="4">
        <conflict type="erroneous gene model prediction">
            <sequence resource="EMBL-CDS" id="EAA64542" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EMBL" id="AACD01000022">
        <property type="protein sequence ID" value="EAA64542.1"/>
        <property type="status" value="ALT_SEQ"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF84806.1"/>
        <property type="status" value="ALT_SEQ"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BDG8"/>
    <dbReference type="SMR" id="Q5BDG8"/>
    <dbReference type="STRING" id="227321.Q5BDG8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN1412"/>
    <dbReference type="eggNOG" id="ENOG502QQ2T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028341_1_0_1"/>
    <dbReference type="InParanoid" id="Q5BDG8"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072665">
        <property type="term" value="P:protein localization to vacuole"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050854">
        <property type="entry name" value="LMBD1_LysCbl_Transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006876">
        <property type="entry name" value="LMBR1-like_membr_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16130:SF2">
        <property type="entry name" value="LYSOSOMAL COBALAMIN TRANSPORT ESCORT PROTEIN LMBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16130">
        <property type="entry name" value="LYSOSOMAL COBALAMIN TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04791">
        <property type="entry name" value="LMBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0846">Cobalamin</keyword>
    <keyword id="KW-0170">Cobalt</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0458">Lysosome</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000365831" description="Probable lysosomal cobalamin transporter">
        <location>
            <begin position="1"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="8"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="314"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="376"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="420"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="504"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="537"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="537"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="575" mass="64190" checksum="5B93CF0AA71DADBC" modified="2009-03-03" version="2">MILLQTSLIWVVYAVVVVVLFAVASVFIYVYQSPRDRSPSVTLTCIVAITSLLATILLLPVDVALVSSTVSSSVGQRKDWATPEVVDRITFSLTLVYYILYSLDILLCLLVVPFVYFWYEEYDEVAAQTGEQSSGQRFWGASKYTLSFIAILIILFLVGVFVPISRANGGNGLDPFKSLLGENRGERALTFALGLLITIGMYVYALHTSTGLAVLPIRLIKGGPRLSNAGSWNATFTVQLDSNRERRRQLEGRCGGNFDHLSSKDRRELDALIREERTLIRRQRLAQEADGKGNALLPRMWFRLEAFFRPFRRLVGLILLLLVLLIWVSMILTASDKAKNSICKRHCGYVLGHINIFNPINEIFVQSAKLFPIDYAIFTMLVLLLFFGTVVGIATVGIRFLWISIFRIRLGHTSPQALLVMTAILMLSILALNYSISMIVAPQYATFGPQTFCDRLSGSSVLPELQCVVKRCSEAFGSDAAKKVCTPSVASTVLNRVTVSFPFFGAIFFWSQFAFIGVYLLALITSLLRSPKLDEQQLDEDAEEAEEEALLSGSRRNMDDRWQSIVGRASRSEDT</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-01-10" modified="2025-04-09" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BDI1</accession>
    <accession>C8VRM2</accession>
    <name>SGO1_EMENI</name>
    <protein>
        <recommendedName>
            <fullName>Shugoshin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">sgo1</name>
        <name type="ORF">AN1399</name>
    </gene>
    <organism>
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays a central role in chromosome cohesion during cell division by preventing premature dissociation of cohesin complex from centromeres after prophase, when most of cohesin complex dissociates from chromosomes arms.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
            <location evidence="1">Centromere</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the shugoshin family.</text>
    </comment>
    <dbReference type="EMBL" id="AACD01000020">
        <property type="protein sequence ID" value="EAA65155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF87574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_659003.1">
        <property type="nucleotide sequence ID" value="XM_653911.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BDI1"/>
    <dbReference type="SMR" id="Q5BDI1"/>
    <dbReference type="EnsemblFungi" id="CBF87574">
        <property type="protein sequence ID" value="CBF87574"/>
        <property type="gene ID" value="ANIA_01399"/>
    </dbReference>
    <dbReference type="KEGG" id="ani:ANIA_01399"/>
    <dbReference type="eggNOG" id="ENOG502SFX7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013723_2_0_1"/>
    <dbReference type="InParanoid" id="Q5BDI1"/>
    <dbReference type="OMA" id="EMNPMAH"/>
    <dbReference type="OrthoDB" id="5394106at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011516">
        <property type="entry name" value="Shugoshin_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07558">
        <property type="entry name" value="Shugoshin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0132">Cell division</keyword>
    <keyword id="KW-0137">Centromere</keyword>
    <keyword id="KW-0158">Chromosome</keyword>
    <keyword id="KW-0159">Chromosome partition</keyword>
    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000055447" description="Shugoshin">
        <location>
            <begin position="1"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="109"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="220"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="263"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="36"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="123"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="270"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="290"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="318"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="335"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="379"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="400"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="479" mass="53260" checksum="82A9119B4F2CFD4D" modified="2005-04-26" version="1">MARLNESTASSEPIEILKRRFVRQNREIARVNSIQSLRIRSLESEVSNLLSENVSLREQIITLTQELERFEAARTLHDGVYDVKARLDSKLVELGNLITELGSLPRRYSRAVRENGEPAPARQSRESGPKEVDDTDPEPNLGFLDGRLPVIMEDKLYPRRTLTAQEVQELRDSDTDGPNCSGFEDSSISPKQRVEYDEAATGGPAYFIDTNTIVEEIENEHSLPPNLETRRKKKIGPATVNKDQADTRPISLLDSKFTRKCGAKRKFSAEDDESLFESSPSEDDEFQFSRPAQSPKLFSQNEHASADDGSGELRRPIQSPTLSSQNDHSPVKMKPQSERSIAHVHGERRVLEPKSTNTNILSPAKPSIMKDYNQNHDFGYNEKSEKPLPRQGKGAVDGSKNASPKKSSTRTPVFGNDGNKSGNKQKKSGAIKSNTPSLDGIEDSEIATTADMPSTRPSRRRGTVSQPESHKTEGISMPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BDP4</accession>
    <accession>C8VS44</accession>
    <name>Q5BDP4_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_01336</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF87694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_658940.1">
        <property type="nucleotide sequence ID" value="XM_653848.1"/>
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    <dbReference type="AlphaFoldDB" id="Q5BDP4"/>
    <dbReference type="GeneID" id="2877114"/>
    <dbReference type="KEGG" id="ani:ANIA_01336"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN1336"/>
    <dbReference type="eggNOG" id="ENOG502RNWY">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_549842_0_0_1"/>
    <dbReference type="InParanoid" id="Q5BDP4"/>
    <dbReference type="OMA" id="QWTTIDP"/>
    <dbReference type="OrthoDB" id="4366200at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
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    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="130"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="384"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="417"/>
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        <location>
            <begin position="320"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="134"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
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            <begin position="146"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="385"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="417"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF87694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="496" mass="54939" checksum="74F13EF85B9282D2" modified="2005-04-26" version="1">MSRGAVEGNSTSLRPDPQEQALMDSHLYMNELGLTPFPGFQLRGDSLQGKEQECSVEHALVDAGRRGEIDQAGGEAVAEISGVPRTGLDEINAGANATVNDMNYSYDPLFDSTVPELDFVFSRKRSAEELSDISSEKRQRQHAESPDQTPSLTTNSTHESHASFFDTFDSLFGGGIELPLVLPDEPLPDFREIPQAPSSLHRTSEFTKEGFSLDEQDILATTTREFLQVRKEPEYKSPYPVSGGPLGYLPSNPALHVTCVAVGDEKMLNEIQSLRAQLYRTTRERDQYKKSLLQYAELDGSGKSPEQLLREENAMLRRVSTRHQSRVEEYKKEAAAWRNKLHEVSTLYNNLLYEIEVTKRLPAISLVPAEYKPHQYGQQIVPLPSMQSAGAGNSQPAGSPTRPLGQQIDAVTIDLTPKSSFPQTSTNSMPAQVTHAYNQPSGPPARQPKQTPEAIMIDLTEEDEPLPTPPPEPEGAALKSLRSKKYGWLNDTYKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BE01</accession>
    <accession>C8VSR2</accession>
    <name>Q5BE01_EMENI</name>
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        <recommendedName>
            <fullName evidence="12">Golgi SNAP receptor complex member 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ANIA_01229</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GOSR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF87894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_658833.1">
        <property type="nucleotide sequence ID" value="XM_653741.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BE01"/>
    <dbReference type="FunCoup" id="Q5BE01">
        <property type="interactions" value="846"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5BE01"/>
    <dbReference type="GeneID" id="2877004"/>
    <dbReference type="KEGG" id="ani:ANIA_01229"/>
    <dbReference type="eggNOG" id="KOG3208">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078034_1_0_1"/>
    <dbReference type="InParanoid" id="Q5BE01"/>
    <dbReference type="OMA" id="EILRDYC"/>
    <dbReference type="OrthoDB" id="422156at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
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    <dbReference type="GO" id="GO:0005801">
        <property type="term" value="C:cis-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0005797">
        <property type="term" value="C:Golgi medial cisterna"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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        <property type="term" value="C:Golgi membrane"/>
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        <property type="project" value="GO_Central"/>
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        <property type="evidence" value="ECO:0000318"/>
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    <dbReference type="GO" id="GO:0005484">
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        <property type="project" value="GO_Central"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="Golgi_SNAP_su1"/>
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        <property type="entry name" value="GOLGI SNAP RECEPTOR COMPLEX MEMBER 1"/>
        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR21094">
        <property type="entry name" value="GOS-28 SNARE- RELATED"/>
        <property type="match status" value="1"/>
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    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="54"/>
            <end position="122"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBF87894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="183" mass="20544" checksum="B1BBB32480E6BA64" modified="2005-04-26" version="1">MASSTGAGWAQLRQQARSLETQTESLFHTYSQYASMTKLPPQPAEEEIRNEHQIRDLLEKRESLLAQLARLLDSEATLTSSALKQNNLARHREVLAEHKRELSRLTAAIAELRDRANLLSNVRSDINAYRSSNPAAAESEYMLEERRRIDESHGVIDGVLSQAARHFRALTGGLWALPAKSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BE90</accession>
    <accession>C8VTA7</accession>
    <name>Q5BE90_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Xylose isomerase-like TIM barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_01140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF88066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_658744.1">
        <property type="nucleotide sequence ID" value="XM_653652.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BE90"/>
    <dbReference type="STRING" id="227321.Q5BE90"/>
    <dbReference type="GeneID" id="2876919"/>
    <dbReference type="KEGG" id="ani:ANIA_01140"/>
    <dbReference type="eggNOG" id="ENOG502S1RE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035063_0_0_1"/>
    <dbReference type="InParanoid" id="Q5BE90"/>
    <dbReference type="OMA" id="HIDTWEA"/>
    <dbReference type="OrthoDB" id="5360893at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.150">
        <property type="entry name" value="Divalent-metal-dependent TIM barrel enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050312">
        <property type="entry name" value="IolE/XylAMocC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12110">
        <property type="entry name" value="HYDROXYPYRUVATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12110:SF21">
        <property type="entry name" value="XYLOSE ISOMERASE-LIKE TIM BARREL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="Xylose isomerase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylose isomerase-like TIM barrel" evidence="1">
        <location>
            <begin position="26"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF88066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="367" mass="40805" checksum="2D9F738544C5DA80" modified="2005-04-26" version="1">MPANLKIGIPTMSLSKPGLHSLDHKLRVAAAHGFAGIELFIDDLSHFASSSFNGSLTQAAKYISSLAKQLNLTFICLQPFGFYEGLVDTNQTTYLLTEKLPLWFAIARIIGTDLIQIPANFLQNDPVTGAARTSGDIRLIVSDLQTIADIGVKQGFRFVYEALCWSTHVDTWEAAWNVVKLVDRENFGICLDSFNIAGRIYADPASVTGKTPDAEQAVAKSMETLRSLVSSGELDIRKIFYIQLVDGERLSAPLDEKHPFHVEGQPPRMSWSRNARLFPCEEERGGYLPVLEIARAFFEIGFEGWVSLELFSRTCNDPDVNTVGEHARRGMDSWRRVVAALGLDVEVPAPERVEVQVQEELAVQHRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="131" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BEI3</accession>
    <accession>C8VTW1</accession>
    <name>Q5BEI3_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Heat shock protein (Eurofung)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ANIA_01047</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF88261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_658651.1">
        <property type="nucleotide sequence ID" value="XM_653559.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BEI3"/>
    <dbReference type="FunCoup" id="Q5BEI3">
        <property type="interactions" value="1446"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5BEI3"/>
    <dbReference type="GeneID" id="2876821"/>
    <dbReference type="KEGG" id="ani:ANIA_01047"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN1047"/>
    <dbReference type="eggNOG" id="KOG0103">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005965_5_1_1"/>
    <dbReference type="InParanoid" id="Q5BEI3"/>
    <dbReference type="OMA" id="WEQSPEI"/>
    <dbReference type="OrthoDB" id="434160at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd24094">
        <property type="entry name" value="ASKHA_NBD_HSP70_ScSse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000171">
        <property type="entry name" value="Heat shock 70 kDa protein 4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000004">
        <property type="entry name" value="Heat shock 70 kDa protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000011">
        <property type="entry name" value="Heat shock protein hsp88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639:SF4">
        <property type="entry name" value="HSC70CB, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639">
        <property type="entry name" value="HSC70CB, ISOFORM G-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="504"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="669"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="669"/>
            <end position="709"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBF88261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="724" mass="81146" checksum="55404EE0B3D7AECD" modified="2005-04-26" version="1">MSVVGIDFGAQSTKIGVARNKGIDIIANEVSNRQTPSLVGFSARSRHIGEAAKTQETSNLKNTVGNLKRLIGRAFSDPEIQIEQEYSVAQLCDVNGQAGVEVSYLGKKEKFSAIQLVAMYLTKIRDITSKELKLPVTDVTISVPAWFTDIQRRAMLDASEIAGLKVLRLINDTTATALGYGITKLDLPGPEEKPRRVMFVDIGYSDYTATIVEFRKGELNVKATACDRHFGGRNFDKALTDHFADEFKEKFKIDIRTNPKAWARTLVAAEKLKKILSANTVAPMSIESLMEDIDVRAMVKREELEDMVRPLLDRVTVPLEQALAEAKLKPEDIDFVEMVGGCTRVPAIKQAVNKFFGKNLSFTLNQDEAIARGCAFSCAILSPVFRVRDFSVHDIVSYPIEFTWEQSPDIPDEDTSLTVFNKGNVMPSTKILTFYRKQPFDLEARYANPEALPGKVNPWVGRFSVKGVKADANDDFMICKLKARLNLHGILNLESGYYVEDVEVEEPVSEEGEKKDGDAMETDAAEQPKKTRKVKKQVRKGDLPISSGTAQLEQSLKDTWQERENSMYMEDKLVAETDEKKNELEGTIYELRDKIDGVYAEFASEEEKDKLRSKLTDLEDWLYEDGEDATKSVYVAKLDEIRFVAGPIIQRHREKLEAERQAILKAQEEEAAKKRAEEEAKRKAEEEAKKAAEEAKKAENPDAEMKDAPNEGEAAPENADADKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BEM9</accession>
    <accession>C8VU65</accession>
    <name>Q5BEM9_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Atos-like conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_01001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF88360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_658605.1">
        <property type="nucleotide sequence ID" value="XM_653513.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BEM9"/>
    <dbReference type="STRING" id="227321.Q5BEM9"/>
    <dbReference type="GeneID" id="2876775"/>
    <dbReference type="KEGG" id="ani:ANIA_01001"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN1001"/>
    <dbReference type="eggNOG" id="KOG2306">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010290_0_0_1"/>
    <dbReference type="InParanoid" id="Q5BEM9"/>
    <dbReference type="OMA" id="CKANLKC"/>
    <dbReference type="OrthoDB" id="8625101at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033473">
        <property type="entry name" value="Atos-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025261">
        <property type="entry name" value="Atos-like_cons_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051506">
        <property type="entry name" value="ATOS_Transcription_Regulators"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13199">
        <property type="entry name" value="GH03947P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13199:SF11">
        <property type="entry name" value="PROTEIN ATOSSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13889">
        <property type="entry name" value="Chromosome_seg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13915">
        <property type="entry name" value="DUF4210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01177">
        <property type="entry name" value="DUF4210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Atos-like conserved" evidence="2">
        <location>
            <begin position="338"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="415"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="600"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="446"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="600"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="620"/>
            <end position="630"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF88360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="728" mass="81448" checksum="F22A84B6FF842C6F" modified="2005-04-26" version="1">MPIFQDSESRQFYDLWSDDPRMTQDDSHLKPSWPDSHDVYAGSSDQRTSVFYGRHPRSPSPTRLNAHDREELIHYIKAAETTKWSQYCSLGDRVGHHVLHSHEVPVTREQSTGNSLYQDFRDHDSELASPAEIERPRSALHSGDFREGTPQLERQQHSPQSPIPDRGINNGLPFFSSSPTSPWFAAPSFPPRTQTAPLQALEARVTEANRTPAPSLAPFSSSYVLKAPTSPLVHQANNTDLDFSTRTDSNNRLTLFDKTNRRRTLPPDSFRDLQTDSADSGANCPIRWDSLSSNSQCSRRSLASSYSLQLASSVQGHYTKSRRPSISAELISRTHAPMVGSYEESILRGRMSTCPSKPLDFTAQIGVLGKGKTKGSLKCPPHVTVRFPAVFYSYPTSGNGRTISDDSPSPYVGMIDLENSLPKDTSCHSRRRRRHQDPVEISSSHNNDESMRTKHNDREAIRRRDKRHRRAESPKAPAGGCYRIPQQGQLQVMIKNPNKTAVKLFLVPYDLSDMEPGTKTFIRQRSYSAGPIIDMPLSARSNYGTDRPEASLTNSDDPNEKPVLRYLIHLNICCPSRGRYYLHSSIRVVFANRVPDGKEKLRNEIQHPEPRYSPYKPSREPTSLRVSTKFSADKGEQRPSPRPPSYRATDDCPPHPFRPIPSIRADVVGLENLVPAQTSSPGPELYNKLGRGDAGYGGYQVGSIASPEGESLLARKLRGLDVQKSDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="114" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BFD3</accession>
    <accession>C8VR88</accession>
    <name>Q5BFD3_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">mitochondrial processing peptidase</fullName>
            <ecNumber evidence="5">3.4.24.64</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Beta-MPP</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">ANIA_00747</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="19">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalytic subunit of the essential mitochondrial processing protease (MPP), which cleaves the mitochondrial sequence off newly imported precursors proteins. Preferentially, cleaves after an arginine at position P2.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of N-terminal transit peptides from precursor proteins imported into the mitochondrion, typically with Arg in position P2.</text>
            <dbReference type="EC" id="3.4.24.64"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the peptidase M16 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.64" evidence="5"/>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF88862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_658351.1">
        <property type="nucleotide sequence ID" value="XM_653259.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BFD3"/>
    <dbReference type="FunCoup" id="Q5BFD3">
        <property type="interactions" value="868"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5BFD3"/>
    <dbReference type="MEROPS" id="M16.980"/>
    <dbReference type="GeneID" id="2876524"/>
    <dbReference type="KEGG" id="ani:ANIA_00747"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN0747"/>
    <dbReference type="eggNOG" id="KOG0960">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009902_4_2_1"/>
    <dbReference type="InParanoid" id="Q5BFD3"/>
    <dbReference type="OMA" id="IDVVCDM"/>
    <dbReference type="OrthoDB" id="10251424at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017087">
        <property type="term" value="C:mitochondrial processing peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097308">
        <property type="term" value="P:cellular response to farnesol"/>
        <property type="evidence" value="ECO:0000270"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006627">
        <property type="term" value="P:protein processing involved in protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000002">
        <property type="entry name" value="Mitochondrial-processing peptidase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000001">
        <property type="entry name" value="Mitochondrial-processing peptidase subunit beta, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050361">
        <property type="entry name" value="MPP/UQCRC_Complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001431">
        <property type="entry name" value="Pept_M16_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851:SF149">
        <property type="entry name" value="GH01077P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851">
        <property type="entry name" value="METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00143">
        <property type="entry name" value="INSULINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="16">
        <location>
            <begin position="51"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="17">
        <location>
            <begin position="203"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CBF88862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="479" mass="53266" checksum="4AD6A46554A4B1C0" modified="2005-04-26" version="1">MASRRLAYNFNQALRSRAALKSIQPVKRGFASPVALPSTTQSTTLSNGFTIATEYSPWAQTSTVGVWIDAGSRAETDKTNGTAHFLEHLAFKGTSKRSQHQLELEIENMGAHLNAYTSRENTVYYAKSFNNDVPKAVDILADILQNSKLESAAIERERDVILREQEEVDKQLEEVVFDHLHATAYQHQPLGRTILGPKENIQTITRDNLTDYIKTNYTADRMVLVGAGGIPHEQLVKLAEQHFGSLPSKPPTSALAALTAEQKRQPEFIGSEIRIRDDTLPTAHIALAVEGVSWKDDDYFTALVAQAIVGNWDRAMGNSPYLGSKLSSFVERNNLANSFMSFSTSYSDTGLWGIYLVSENMTGLDDLIHFALREWSRLSFNVTAAEVERAKAQLKASILLSLDGTTAIAEDIGRQIITTGRRLSPEDIERTIGQITEKDVMDFANRKLWDQDIAMSAVGSIEGILDYNRIRSDMSRNAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="102" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BFF3</accession>
    <accession>C8VRA8</accession>
    <name>Q5BFF3_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">U4/U6 small nuclear ribonucleoprotein, putative (AFU_orthologue AFUA_1G13890)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ANIA_00727</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF88900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_658331.1">
        <property type="nucleotide sequence ID" value="XM_653239.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BFF3"/>
    <dbReference type="FunCoup" id="Q5BFF3">
        <property type="interactions" value="696"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5BFF3"/>
    <dbReference type="GeneID" id="2876505"/>
    <dbReference type="KEGG" id="ani:ANIA_00727"/>
    <dbReference type="eggNOG" id="KOG2769">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015750_2_2_1"/>
    <dbReference type="InParanoid" id="Q5BFF3"/>
    <dbReference type="OMA" id="CVMHPRF"/>
    <dbReference type="OrthoDB" id="10264544at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd24162">
        <property type="entry name" value="Prp3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013881">
        <property type="entry name" value="Pre-mRNA_splic_Prp3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027104">
        <property type="entry name" value="Prp3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010541">
        <property type="entry name" value="Prp3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14212">
        <property type="entry name" value="U4/U6-ASSOCIATED RNA SPLICING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14212:SF0">
        <property type="entry name" value="U4_U6 SMALL NUCLEAR RIBONUCLEOPROTEIN PRP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08572">
        <property type="entry name" value="PRP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06544">
        <property type="entry name" value="Prp3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="domain" description="Pre-mRNA-splicing factor 3" evidence="7">
        <location>
            <begin position="202"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="Small nuclear ribonucleoprotein Prp3 C-terminal" evidence="6">
        <location>
            <begin position="441"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="45"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="71"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="102"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBF88900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="591" mass="65695" checksum="C71A397C3E920F15" modified="2005-04-26" version="1">MADMSGNMLKRPHPDDEDNNAQKRPRSNNGSPHPGQGAPAAGNIDIEKIVAEARAKAQAVRDRLMAEKRVSASPSPAPAASSPSPAPPAASSTMSRIEQMKARVAAATGRSQAAAQQPSAPTPPPLPRAPEDDEDDSLSRARGGLDVGLHPALLSDTLDFRGSKGRQVQSRNRRTESPGVSGKQERAGLDLSGPSLEEIKNNPYYDPNLGPKATISKPRQSRQLLFNQKGKYIQQAAALRRQAQLEEMKKRIAERARQAGIDEDLDVEKAFMVPAPPAIEWWDEHLVNEPDYAAIDDENNLKIDSADSIITRYIQHPVLLEPPQEKLKPEQKPMYLTPKEQAKIRRQRRMADLKEQQAKIRLGLEPAPPPKVKKSNLMRVLGEQAVKDPTAVEARVNREIAERREKHEATNEERKLTKEQRHEKLARQQAQDAEKGLIMTVYRIDSLANGRHRFKISKNAEQNALTGVCVMHPKFNLVIVEGGAHSSNNYRKLMMNRIDWTENAGPSAVREGNREAQASWLAAEDEKGELKDLSSNTCTLLWEGQVKARAFRKWLGARVCETDSQAKDVLARAKLESFWTLAKSAKQQGEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="119" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BFQ3</accession>
    <accession>C8VS28</accession>
    <name>Q5BFQ3_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FYVE domain protein, putative (AFU_orthologue AFUA_1G17070)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ANIA_00627</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF89105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_658231.1">
        <property type="nucleotide sequence ID" value="XM_653139.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BFQ3"/>
    <dbReference type="FunCoup" id="Q5BFQ3">
        <property type="interactions" value="143"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5BFQ3"/>
    <dbReference type="GeneID" id="2876403"/>
    <dbReference type="KEGG" id="ani:ANIA_00627"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN0627"/>
    <dbReference type="eggNOG" id="KOG1729">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082207_0_0_1"/>
    <dbReference type="InParanoid" id="Q5BFQ3"/>
    <dbReference type="OMA" id="LDQDANY"/>
    <dbReference type="OrthoDB" id="10018316at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15760">
        <property type="entry name" value="FYVE_scVPS27p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23164">
        <property type="entry name" value="EARLY ENDOSOME ANTIGEN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23164:SF30">
        <property type="entry name" value="EARLY ENDOSOME ANTIGEN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="6">
        <location>
            <begin position="156"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="64"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="223"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="29"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="89"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="259"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBF89105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="281" mass="30940" checksum="A8C35EB57618224D" modified="2005-04-26" version="1">MATHVMTATTTAPINQISVYQHPSPVHSGASTPANNSPTSPRLQYLPLQTRQLRPPKAPLYVPAALRPTERPSKPSPPTPPRSVHGSLDSLNDGETTSEPVSRRATMETVSSTGGIRKMAEHEWMKNEQLGAVTGLPTREHWKADSASRSCDSPTCRSSFGLFLRRHHCRHCGHVFCSSHTPHVVPLDQEARFHPDGVPSRACDLCWSAYQRWEEARAERLSKIQQSIDSQDEDDQSSDGHSPTSSVEASLAEGRKQEPTNPGQNSEIAASVPRGWNWSTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="116" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BG25</accession>
    <accession>C8VSX1</accession>
    <name>Q5BG25_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Nonsense-mediated mRNA decay protein Upf3, putative (AFU_orthologue AFUA_6G11460)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ANIA_00505</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RENT3 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF89348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_658109.1">
        <property type="nucleotide sequence ID" value="XM_653017.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BG25"/>
    <dbReference type="STRING" id="227321.Q5BG25"/>
    <dbReference type="GeneID" id="2876277"/>
    <dbReference type="KEGG" id="ani:ANIA_00505"/>
    <dbReference type="eggNOG" id="KOG1295">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018549_0_0_1"/>
    <dbReference type="InParanoid" id="Q5BG25"/>
    <dbReference type="OMA" id="QYKPGKV"/>
    <dbReference type="OrthoDB" id="18087at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd12455">
        <property type="entry name" value="RRM_like_Smg4_UPF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000637">
        <property type="entry name" value="Nonsense-mediated mRNA decay protein Upf3, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000797">
        <property type="entry name" value="Nonsense-mediated mRNA decay protein Upf3, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039722">
        <property type="entry name" value="Upf3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005120">
        <property type="entry name" value="UPF3_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13112:SF0">
        <property type="entry name" value="FI21285P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13112">
        <property type="entry name" value="UPF3 REGULATOR OF NONSENSE TRANSCRIPTS-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03467">
        <property type="entry name" value="Smg4_UPF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0866">Nonsense-mediated mRNA decay</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="427"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="208"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="496"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="208"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="273"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="359"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="414"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="496"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="534"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="563"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBF89348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="590" mass="61822" checksum="D7963C2930DD98E3" modified="2005-04-26" version="1">MTQILSKSSGGVLQIPASATQKNAPAPKKAPKPVAPRLKLLVRRLPPGLTQEEFETALGAEWKLGAGRVSWAQYKPGKVSKDHGNHSPAKPSRPSRAYLYVVSSEHIAPLSDKVRSTSFLDARNTANDPVLLGPPNLEFAPYAKIPGSRVRKDARLGTIDQDPEFIQFLESLTQPITKPTLAETSAEGEDKKETVTTTPLVQYIKEKKANKAKEAASKSSRQRSEREAKSEKVQSKKLLQRPDKEVSPANAEKTEKKSRSDKSTKEAVKAASKQAANVASRQAAKASAAQNASKDMAAAASERKRERGNVAAVGKILQRDLGLAPSNNRRRGGRGTSGENEPKTDSAAASETSKKEISTRSPKGSPAQDTSSKTKRSNTPQPSETPQSQRSDTSTPAQATSTPRGPRSGRGKQSSAATPTTPTSTATQAFLKHANPSQGVTEPLLEAAFLPFGKVVKVEIDKKKGFGYVDFAEPEGLQKAISASPVTVAQSQVVVLERKANPGAEKGRGKGRGEPKPPNPSASGEANSNSGRNGKSGEGTGGGGSGGGNSSSGRGRRGRGKGGSKANGGGGSGTTSANAPAPENKNSETK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="135" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BH84</accession>
    <accession>C8VQN1</accession>
    <name>Q5BH84_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Transcription factor with C2H2 and Zn(2)-Cys(6) DNA binding domain (Eurofung)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ANIA_00096</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF90208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_657700.1">
        <property type="nucleotide sequence ID" value="XM_652608.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BH84"/>
    <dbReference type="GeneID" id="2875874"/>
    <dbReference type="KEGG" id="ani:ANIA_00096"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003864_1_0_1"/>
    <dbReference type="InParanoid" id="Q5BH84"/>
    <dbReference type="OMA" id="FRACYKC"/>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001281">
        <property type="entry name" value="C2H2 transcription factor, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001719">
        <property type="entry name" value="C2H2 type zinc finger domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660:SF7">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="43"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="115"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="163"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="298"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="380"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="20"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="399"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CBF90208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="993" mass="111120" checksum="5A7A5231AA195622" modified="2005-04-26" version="1">MTEEKSDIGQEGSDPQEIDSTSKSEGASHDREVEETSSATGQTKCSICQSTFRRPEHLKRHFRSHTKEKPFECTQCGRHFSRTDTLHRHELSHHTIGADGGKDRTHRITVKTFRACYKCALARVRCSGGMPCTRCETRSLECQYPTERRSKAKIRKGVTQPMLLDDRDPFSGQSSHTFSVQGPETSRNEGSGNPDIQPGYQISQFQLRVRASQNPSTSSPGGTAAPEMHARSQNPLENREESHLVASPSLVRPDVTAVSEAVPRTFPPLAGVNGQFYTPAQVQNAIPIEQRRFSHPVGSRQHEIPGPGTAVSGIPGSGDQNAQLDFSQSFLGQSTVSPLNWLSSDLFLESASDHGLPSGPLPQPFQTGVFDSSLGQTTWLPPVINAEPNGSSISGSISHTTPSATTSLGDVESPGNLVRGPRQSSQSGPSKRPTDYNIDEPVERLNKQRKQSTWPTQFAEPLDIFLKFQNVNSKPRFAFPPPSEGQTNTIPDTQVNCKLEDLTYDQIHDAFTRLCFTLALAAMGSHSANLCEQNGTATAFHEFLRRALCVEKEKRQPEYLQLWLIQALLLSCIGRLHGNSESGKLSALADFGDLVNLANRQRLLSRSENPNTSTDQSSPEQQWLLWVEEEARRRTGYVIWLVDCTVAYEFDTKPYFCLDDGQAPLPCNENIWHAASSRIWKGLREEISEQEKISLYDAVLILYIEKRLVPEIGELSHILLIHALYHRMWEVGDYFRRPLSFWNPTAKKQSRKLAIPSGSVWLPGIPSYSKWRNSACDCLDILHWTANGTIAKANGHEHPTILHLHTARIILLAPFREIRLLVNLLATQKVNWEDRQKVIEWHYILRWIKHDQYKARLAVIHAGSVLYHVRKYSTNAFHEPVATYLAILTLWAYGLCYKQASPDVTATRHDSSVGPSVINLDQPCSDELVQSFVREGQKMKGMLTNVGDICAPHGPEQILRVGCETLGRLRSWGIAKEFMVTLMRLAELFSAYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>C8V1F6</accession>
    <name>C8V1F6_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Zn(II)2Cys6 transcription factor (Eurofung)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ANIA_06667</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF71211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467139.1">
        <property type="nucleotide sequence ID" value="XM_050613358.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V1F6"/>
    <dbReference type="STRING" id="227321.C8V1F6"/>
    <dbReference type="GeneID" id="2870453"/>
    <dbReference type="KEGG" id="ani:ANIA_06667"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN6667"/>
    <dbReference type="eggNOG" id="ENOG502SJ8Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004804_0_1_1"/>
    <dbReference type="InParanoid" id="C8V1F6"/>
    <dbReference type="OMA" id="PAQWWIM"/>
    <dbReference type="OrthoDB" id="5392779at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47840:SF4">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47840">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="20"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="87"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="562"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBF71211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="706" mass="77563" checksum="233496698857432D" modified="2009-11-03" version="1">MLDEDIHLPKRRKVRKGTQSCWECKRRKVRCMFSSAGHAICNNCRRRGTACVSQELPDTTGTSSGQSQVEARLSLVEELIERLVDARATPSLERDGPDAGSPVYRAVPSRPPTTTRPLPVGPGPDQYEELSRDLLDVWPSRDDLETISSLPVGLLCLPLCWRTCALPGDQSPREMLKLPASGAHPVLIAQRLLRLGIFLQGVPPAAIKQLGDRGVSYRETMTRSVERAIALVTTNDELITSVEGLECIMMEVMYQNYAGNLRRAWMAVKRAISAAQIMGFHRAQDLPASRFLDPATRAAFDADNICFRLVQMDHYLSLMLGLPQTAPEGRFAIPTDLPDLDPQDRLERLHCTVSGRIVQRNDAGINDLSITCEADKLLQTAAAEMPPQWWLPPTFSEDSNLVADTIRLMIQFTHHHLLARLHLPYMLRSSTSTDHNHDRSRTIAVNASRELLSRYILFRSRNPADYYCRGCDFLAFVATTIMCLAHINTNTHSNSNNTNPFDPLTHSRPTDRGLMERTAEIIASTAAAEYGVSEAIAPKLNRIIRHLLDVESNAANGTIYSTSTSSSAADGDEGEIGGALSQGGKSLQIRIPYFGTIRLERGHGSILKGSEVEVQGQGTAAGSYGMASAHAEVPVSSSWGVDHDIRTSHSQVPISNESGGIESQLDSMYSGAEDDWNLQGIDVALFDSLFRGIGIPDADTNGEAWI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-10-19" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>C8V330</accession>
    <accession>Q5B0B3</accession>
    <name>EIF3G_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Eukaryotic translation initiation factor 3 subunit G</fullName>
            <shortName evidence="1">eIF3g</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Eukaryotic translation initiation factor 3 RNA-binding subunit</fullName>
            <shortName evidence="1">eIF-3 RNA-binding subunit</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Translation initiation factor eIF3 p33 subunit homolog</fullName>
            <shortName evidence="1">eIF3 p33 homolog</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">tif35</name>
        <name type="ORF">AN10765</name>
    </gene>
    <organism>
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. This subunit can bind 18S rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF-3 subunit G family.</text>
    </comment>
    <comment type="sequence caution" evidence="3">
        <conflict type="erroneous gene model prediction">
            <sequence resource="EMBL-CDS" id="EAA57658" version="1"/>
        </conflict>
        <text>The predicted gene AN6017 has been split into 2 genes: AN10765 and AN10767.</text>
    </comment>
    <dbReference type="EMBL" id="AACD01000103">
        <property type="protein sequence ID" value="EAA57658.1"/>
        <property type="status" value="ALT_SEQ"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF70356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V330"/>
    <dbReference type="SMR" id="C8V330"/>
    <dbReference type="FunCoup" id="C8V330">
        <property type="interactions" value="1084"/>
    </dbReference>
    <dbReference type="STRING" id="227321.C8V330"/>
    <dbReference type="EnsemblFungi" id="CBF70356">
        <property type="protein sequence ID" value="CBF70356"/>
        <property type="gene ID" value="ANIA_10765"/>
    </dbReference>
    <dbReference type="GeneID" id="2870983"/>
    <dbReference type="KEGG" id="ani:ANIA_10765"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN10765"/>
    <dbReference type="eggNOG" id="KOG0122">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019836_0_0_1"/>
    <dbReference type="InParanoid" id="C8V330"/>
    <dbReference type="OMA" id="ICQGDHF"/>
    <dbReference type="OrthoDB" id="639027at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071540">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3e"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071541">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3m"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043614">
        <property type="term" value="C:multi-eIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002188">
        <property type="term" value="P:translation reinitiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006415">
        <property type="term" value="P:translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd12933">
        <property type="entry name" value="eIF3G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12408">
        <property type="entry name" value="RRM_eIF3G_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000328">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03006">
        <property type="entry name" value="eIF3g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017334">
        <property type="entry name" value="eIF3_g"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024675">
        <property type="entry name" value="eIF3g_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034240">
        <property type="entry name" value="eIF3G_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10352">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12353">
        <property type="entry name" value="eIF3g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037949">
        <property type="entry name" value="Transl_init_eIF-3_RNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0396">Initiation factor</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <feature type="chain" id="PRO_0000365444" description="Eukaryotic translation initiation factor 3 subunit G">
        <location>
            <begin position="1"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="1">
        <location>
            <begin position="209"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="289" mass="31556" checksum="D30D3A60ECFCC81B" modified="2009-11-03" version="1">MSRPTKADWADDEEFDDPSALPPQQITTNKDGTKTVVSYRFNDEGKKVKVTRRIKTTVVREHVNPQVAERRTWAKFGLEKGHAAGPSFDTTSVGENIVFRPSVNWKAQAAEAEKNGGEKGSIKDQLKDKKVKCRICSGEHFTARCPFKDTMAPVDEPGAGGAEGGAAAGEDAAGGLGAGGGSYVPPHLRKGAAGGGERMAGKYEKDDLATLRVTNVSELAEEQELRDLFERFGRVTRVFLARDRETQRAKGFAFISFADRSDAARACDKMDGFGYRHLILRVEFAKRAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>C8V3Q0</accession>
    <name>C8V3Q0_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ANIA_08278</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF74265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467297.1">
        <property type="nucleotide sequence ID" value="XM_050611251.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V3Q0"/>
    <dbReference type="GeneID" id="2869111"/>
    <dbReference type="KEGG" id="ani:ANIA_08278"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN8278"/>
    <dbReference type="eggNOG" id="ENOG502S522">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_109915_3_1_1"/>
    <dbReference type="InParanoid" id="C8V3Q0"/>
    <dbReference type="OMA" id="ITTIFWF"/>
    <dbReference type="OrthoDB" id="2117453at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008253">
        <property type="entry name" value="Marvel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37451">
        <property type="entry name" value="MARVEL DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37451:SF1">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01284">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="115"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="MARVEL" evidence="6">
        <location>
            <begin position="9"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBF74265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="155" mass="17057" checksum="DB7821578C3D3AC0" modified="2009-11-03" version="1">MAKFDFPLFYILRAVQAVFAVIVLGLTGHAVNVTDGHWWDTINFMLFNGVWTLFIVVPYFILAPIFVPAIAHRWVLVAVDTITMIFWFAGFIALAVDLGDAHGCSKWSPCRGLQAAAAFGAFNWVLFLVTTVLNTMGALRRDPAPGPQPPTAHVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C8V6G7</accession>
    <name>C8V6G7_EMENI</name>
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        <submittedName>
            <fullName evidence="5">60S ribosomal protein L38, putative (AFU_orthologue AFUA_4G07845)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ANIA_11419</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL38 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF75215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467426.1">
        <property type="nucleotide sequence ID" value="XM_050611392.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V6G7"/>
    <dbReference type="FunCoup" id="C8V6G7">
        <property type="interactions" value="856"/>
    </dbReference>
    <dbReference type="STRING" id="227321.C8V6G7"/>
    <dbReference type="GeneID" id="74897007"/>
    <dbReference type="KEGG" id="ani:ANIA_11419"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN11419"/>
    <dbReference type="eggNOG" id="KOG3499">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_152057_1_0_1"/>
    <dbReference type="InParanoid" id="C8V6G7"/>
    <dbReference type="OMA" id="RCHRFIY"/>
    <dbReference type="OrthoDB" id="10250488at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022618">
        <property type="term" value="P:protein-RNA complex assembly"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.720.90:FF:000001">
        <property type="entry name" value="60S ribosomal protein L38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002675">
        <property type="entry name" value="Ribosomal_eL38"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038464">
        <property type="entry name" value="Ribosomal_eL38_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10965">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10965:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01781">
        <property type="entry name" value="Ribosomal_L38e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBF75215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="80" mass="9259" checksum="4326240717F0998A" modified="2009-11-03" version="1">MPREVSDIKQFIELARRKDASSARIKRNRKTQQIKFKVRCSRFVYTLVLKDSDKADKLKQSLPPALKVVDVTKGDKKKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2025-10-08" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>C8V746</accession>
    <name>C8V746_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">5'-3' exoribonuclease 1</fullName>
            <ecNumber evidence="6">3.1.13.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">ANIA_11052</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Multifunctional protein that exhibits several independent functions at different levels of the cellular processes. 5'-3' exonuclease component of the nonsense-mediated mRNA decay (NMD) which is a highly conserved mRNA degradation pathway, an RNA surveillance system whose role is to identify and rid cells of mRNA with premature termination codons and thus prevents accumulation of potentially harmful truncated proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5'-3' exonuclease family. XRN2/RAT1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.-" evidence="6"/>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF74062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_681454.2">
        <property type="nucleotide sequence ID" value="XM_676362.2"/>
    </dbReference>
    <dbReference type="SMR" id="C8V746"/>
    <dbReference type="FunCoup" id="C8V746">
        <property type="interactions" value="858"/>
    </dbReference>
    <dbReference type="STRING" id="227321.C8V746"/>
    <dbReference type="GeneID" id="2868996"/>
    <dbReference type="KEGG" id="ani:ANIA_11052"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN11052"/>
    <dbReference type="eggNOG" id="KOG2045">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001581_1_2_1"/>
    <dbReference type="InParanoid" id="C8V746"/>
    <dbReference type="OMA" id="VASWPWF"/>
    <dbReference type="OrthoDB" id="372487at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004534">
        <property type="term" value="F:5'-3' RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd18673">
        <property type="entry name" value="PIN_XRN1-2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.1050:FF:000002">
        <property type="entry name" value="5'-3' exoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12390:FF:000002">
        <property type="entry name" value="5'-3' exoribonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12390">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027073">
        <property type="entry name" value="5_3_exoribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016494">
        <property type="entry name" value="5_3_exoribonuclease_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041385">
        <property type="entry name" value="SH3_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040992">
        <property type="entry name" value="XRN1_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047007">
        <property type="entry name" value="XRN1_D1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041106">
        <property type="entry name" value="XRN1_D2_D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041412">
        <property type="entry name" value="Xrn1_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004859">
        <property type="entry name" value="Xrn1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047008">
        <property type="entry name" value="XRN1_SH3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12341:SF7">
        <property type="entry name" value="5'-3' EXORIBONUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12341">
        <property type="entry name" value="5'-&gt;3' EXORIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18129">
        <property type="entry name" value="SH3_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18332">
        <property type="entry name" value="XRN1_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18334">
        <property type="entry name" value="XRN1_D2_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17846">
        <property type="entry name" value="XRN_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03159">
        <property type="entry name" value="XRN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006743">
        <property type="entry name" value="Exonuclease_Xnr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6 13" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0866">Nonsense-mediated mRNA decay</keyword>
    <keyword evidence="3 6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Xrn1 N-terminal" evidence="8">
        <location>
            <begin position="1"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Xrn1 helical" evidence="9">
        <location>
            <begin position="275"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="domain" description="5'-3' exoribonuclease 1 D1" evidence="11">
        <location>
            <begin position="720"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="domain" description="Exoribonuclease Xrn1 D2/D3" evidence="12">
        <location>
            <begin position="911"/>
            <end position="1133"/>
        </location>
    </feature>
    <feature type="domain" description="5'-3' exoribonuclease 1 SH3-like" evidence="10">
        <location>
            <begin position="1152"/>
            <end position="1222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1236"/>
            <end position="1398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1236"/>
            <end position="1246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1274"/>
            <end position="1283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="1317"/>
            <end position="1327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1331"/>
            <end position="1354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR006743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF18129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF18332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF18334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CBF74062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="1398" mass="157590" checksum="1C20F7DA1CE7A9C0" modified="2009-11-03" version="1">MGVPKFFRWLSERYPAISMLIAENRIPEFDNLYLDMNGIIHNCTHKDSDSPTFRMTEDKMFIAIFNYIEHLYGKIKPKKLFFMAVDGVAPRAKMNQQRARRFRTALDAEQAKEKAIAQGIEMPKEDPFDSNCITPGTEFMAKLTEQLKYFISKKISEDKDWQGVEIVLSGHEVPGEGEHKIMEYIRHAKAQPGYDPNVRHCLYGLDADLIMLGLLSHDPHFCLLREEVTFGRQVQKKPKELEHQNFYLLHLCMVREYLQLEFQELEEEGIIDFPYEFERVIDDFILMAFFVGNDFLPNLPNLHINEGALSLMFKVYKEVLPKMGGYINEQGTINLQRLGVLLDALSHVEYRFFEAEYSDATWMRAKQSADNGADVDAKPKTFTVTPDQKNILKTVKKYVLNRPGKAADSKPLDFPPTLPARDRKFVEQLADDLRLPWSTVSNDDGDRFIRIQFPSNENDDSEEEEDEEASMAVRRVIRKYENAKVQELSAEEALAAAQKKYEEKFQDWKDKYYMEKFGWGLDNHEEMRKLTENYVQGLQWVLFYYYRGIASWPWFFNSHYAPMISDVKKGLNADMNFRLGRPFRPYDQLMGVLPDRSKKIVPKAYHDLMSSPDSPIIDFYPRDFELDMNGKKMEWEAVVKIPFIDERRLLDALATREHLLTPEEKARNGFGVSLKFTYSPDTEYIYPSSLPGVFPDIPNCRCIQNVFDLPTMDGLEPYVGLVEGVHLGASALAGFPSLKTLPHAGQLGFHGVCVFQQESRNESMVITVLDPGSRSSSELAKKKLGQRVFVGYPFLQEALVTRVSDELFDYTLPAGEEHPLATPHSDAQIEQWKKKADKIEGIYSRRFGTIIGPVEAMVHVQLLKGLIKTDSGATVKEFADIPGQETDYALQLVVDEVINPDERFIEREALPVEKEFPEGSRAFFLGEFNYGRPVHITGHDDGKVNGLIAVIKGREPEFGRERARNAEALSPYMPAFAVARILQLNPLTLAKITSSFSVDVDGQRVNLGLNLKFEARKQKVLGYSRRSESGWEFSAKAIGLVEQYMLKFPQFIAGIQRNPRNDRYQPTDFYPPDIALDKINEIKAWLKEIESKNFERVPLEAEQLDSDVVKLIEQDADQLVKTQPPMEAKKIRDIPRSALLRPADVEHRLGNQTFKLGDRVVYAQDSGKVPIATRGTVVGLTRTPRAILLDVVFDVAFMSGTTLGDRCSPFRGQTVLASSVLNLSYRQLVASTRAAVNQKQQNQPSPLTVKGYGAPLGPGGQGQLKEAPAPPPLRGSFRGALSGARGGRGDANGTATLPFRPHPETNGSARGSRGRGRGGGVARGRGGYVSVDNSDPNAGVVQNNPNFRPKNYSQVPPPSGLEYRGRGRGRGARGGDRGNGYRGRGSHRGRGAAATAGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C8V7K2</accession>
    <name>C8V7K2_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">ANIA_10454</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SDE2 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF75570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467479.1">
        <property type="nucleotide sequence ID" value="XM_050611450.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V7K2"/>
    <dbReference type="STRING" id="227321.C8V7K2"/>
    <dbReference type="GeneID" id="74896411"/>
    <dbReference type="KEGG" id="ani:ANIA_10454"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN10454"/>
    <dbReference type="eggNOG" id="KOG2827">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060603_0_0_1"/>
    <dbReference type="InParanoid" id="C8V7K2"/>
    <dbReference type="OMA" id="RAPWIQN"/>
    <dbReference type="OrthoDB" id="547031at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051421">
        <property type="entry name" value="RNA_Proc_DNA_Dmg_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053822">
        <property type="entry name" value="SDE2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024974">
        <property type="entry name" value="Sde2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12786">
        <property type="entry name" value="SPLICING FACTOR SF3A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12786:SF1">
        <property type="entry name" value="SPLICING REGULATOR SDE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22782">
        <property type="entry name" value="SDE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13019">
        <property type="entry name" value="Sde2_N_Ubi_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sde2 ubiquitin" evidence="11">
        <location>
            <begin position="5"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="SDE2-like" evidence="12">
        <location>
            <begin position="91"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="98"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="206"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="151"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="270"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF22782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CBF75570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="299" mass="32275" checksum="917229A0B178FDB3" modified="2009-11-03" version="1">MASHVNVLLSSFPGLSLPPTVSFALPATSTLSDLCEKVSSYIPYSVPLRSLILTTTNNKQILPSSLAVSELISPNGDSTLLPLRLTVPMCGGKGGFGSQLRAAGGRMSSRRKRNQGDDNGSSRNLDGRRLRTVNEAKALAEYLAVKPEMDKKEKEERRRRWEAVVEAAEKRQEELKNGGGKQKIDGQWMEDKDEMNEKAREAVLAAMKEGTWTDNLKDALLGGSSTSASEGSGQESASASEDSGEEAEMRDAPAQPGSARPAAPRRYIGFDDDDEFMSDSEEDEEAMNEGSEGKGKAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C8V8L8</accession>
    <name>C8V8L8_EMENI</name>
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        <submittedName>
            <fullName evidence="2">N-acetylglucosaminyl transferase component Gpi1 (AFU_orthologue AFUA_3G09860)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_10611</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
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        <lineage>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF76292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_657518.2"/>
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    <dbReference type="AlphaFoldDB" id="C8V8L8"/>
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    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007720">
        <property type="entry name" value="PigQ/GPI1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21329:SF3">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21329">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT Q-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05024">
        <property type="entry name" value="Gpi1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="260"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="345"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="420"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="461"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF76292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="665" mass="76068" checksum="34E3BDE7F58C2586" modified="2009-11-03" version="1">MSDGLLRVFWPYDLPRSSAPGVIVGWRNSELDLFVLAVLEDVEPRNVDNALRAGILFRNSPHPVPRIFSLCGRSSMHVLGSTNMRDPPTAFNASHLIVTTRPSCKVPKIYCPPETGLSIQVIMFHRPDPTRMEYMSLNPISLALEDKMLAADKSDGVLDTIETEEGAQKARAQRLVDKLRLHTVVKHLPSHKELALPFIINQINCAYEMGKLIEKNSSLIGIRVKRSMSVSERVVESATTVWDLFVLGVSYVFWQWIWPVITRIFVIGLVFHRVIADFVLQVLEWRARPDAAALKDISATAQQVDIRLQQFCYWPTQYVKLRQRKDDWESVTTYHAHYIRFYNSLWLVANDVIIGIALGSYIIDNANWVAYQINYILSGWTVEGLQRTISWLMDWPAGLKLNNELAAFLGDLFLWVIENWAARIFNWQLTIIISLFHLFRGKKRNVLRNRIDSCDYDLDQLLLGTILFTVLFFLLPTVIVFYLAFTSARMLIISLKAALDTWLAFLNHFPLFALMLRVKDSRRLPGGIRFELREEHDTLPNSVDSTIHYIHLESIPLTLRAMFDQYFQLAHRLRKHYLSPQVIFCLFTGRFVPPIHRRSLYSMQYSMLPDVRPSLAQVWSELTQPARKSSGGGSGGVSGQGGNSIGIGIMGMKMGGLAERRRGYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>C8V8V6</accession>
    <name>C8V8V6_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ANIA_11436</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF77631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467738.1">
        <property type="nucleotide sequence ID" value="XM_050611746.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V8V6"/>
    <dbReference type="GeneID" id="74897021"/>
    <dbReference type="KEGG" id="ani:ANIA_11436"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN11436"/>
    <dbReference type="HOGENOM" id="CLU_2704782_0_0_1"/>
    <dbReference type="InParanoid" id="C8V8V6"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF77631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="73" mass="8404" checksum="7F704731D202D6A8" modified="2009-11-03" version="1">MSQGLAVFPWSRSGEETLPFWLNASHLERATNPRNRDICLVCFPEYEVPGPWSFRSLADHISFHEGRNLKLGM</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-10-19" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>C8V9B7</accession>
    <accession>Q5AS69</accession>
    <name>ITPA_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Inosine triphosphate pyrophosphatase</fullName>
            <shortName evidence="1">ITPase</shortName>
            <shortName evidence="1">Inosine triphosphatase</shortName>
            <ecNumber evidence="1">3.6.1.66</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Non-canonical purine NTP pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Non-standard purine NTP pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Nucleoside-triphosphate diphosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Nucleoside-triphosphate pyrophosphatase</fullName>
            <shortName evidence="1">NTPase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">XTP/dITP diphosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="ORF">AN8861</name>
    </gene>
    <organism>
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ITP + H2O = IMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:29400"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>dITP + H2O = dIMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28342"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61194"/>
            <dbReference type="ChEBI" id="CHEBI:61382"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:28343"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>XTP + H2O = XMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28610"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:61314"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:28611"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="1">Binds 1 divalent metal cation per subunit; can use either Mg(2+) or Mn(2+).</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the HAM1 NTPase family.</text>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="erroneous gene model prediction">
            <sequence resource="EMBL-CDS" id="EAA60149" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EC" id="3.6.1.66" evidence="1"/>
    <dbReference type="EMBL" id="AACD01000163">
        <property type="protein sequence ID" value="EAA60149.1"/>
        <property type="status" value="ALT_SEQ"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF77855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V9B7"/>
    <dbReference type="SMR" id="C8V9B7"/>
    <dbReference type="FunCoup" id="C8V9B7">
        <property type="interactions" value="723"/>
    </dbReference>
    <dbReference type="STRING" id="227321.C8V9B7"/>
    <dbReference type="EnsemblFungi" id="CBF77855">
        <property type="protein sequence ID" value="CBF77855"/>
        <property type="gene ID" value="ANIA_08861"/>
    </dbReference>
    <dbReference type="KEGG" id="ani:ANIA_08861"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN8861"/>
    <dbReference type="eggNOG" id="KOG3222">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082080_1_2_1"/>
    <dbReference type="InParanoid" id="C8V9B7"/>
    <dbReference type="OMA" id="YDPIFQP"/>
    <dbReference type="OrthoDB" id="6288734at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035870">
        <property type="term" value="F:dITP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036220">
        <property type="term" value="F:ITP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047429">
        <property type="term" value="F:nucleoside triphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036222">
        <property type="term" value="F:XTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009204">
        <property type="term" value="P:deoxyribonucleoside triphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009143">
        <property type="term" value="P:nucleoside triphosphate catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00515">
        <property type="entry name" value="HAM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.950.10:FF:000003">
        <property type="entry name" value="Inosine triphosphate pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03148">
        <property type="entry name" value="HAM1_NTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027502">
        <property type="entry name" value="ITPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002637">
        <property type="entry name" value="RdgB/HAM1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00042">
        <property type="entry name" value="RdgB/HAM1 family non-canonical purine NTP pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11067:SF9">
        <property type="entry name" value="INOSINE TRIPHOSPHATE PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11067">
        <property type="entry name" value="INOSINE TRIPHOSPHATE PYROPHOSPHATASE/HAM1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01725">
        <property type="entry name" value="Ham1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="ITPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0464">Manganese</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0546">Nucleotide metabolism</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000413138" description="Inosine triphosphate pyrophosphatase">
        <location>
            <begin position="1"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="8"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="64"/>
            <end position="65"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="140"/>
            <end position="143"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="166"/>
            <end position="167"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="183" mass="20091" checksum="24F47F570D84C7C7" modified="2009-11-03" version="1">MKTINFITGNKNKLAEVRAIIGNVVDVQNQTVDVPEIQGTIEEIAKEKCRHAANAVGGPVLTEDTALGFHALKGLPGPYIKFFLEALGHEGLNKMLDGFESRGAEAVCTFAFSPGPGSEPILFQGRTEGVIVSPRGPANFGWDPIFEYEGQTYAEMTKEEKNKISHRYKALVKLQQWLVDELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>C8VAU1</accession>
    <name>C8VAU1_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">MAT2</name>
        <name evidence="7" type="ORF">ANIA_04734</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF76901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467652.1">
        <property type="nucleotide sequence ID" value="XM_050611646.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VAU1"/>
    <dbReference type="STRING" id="227321.C8VAU1"/>
    <dbReference type="GeneID" id="2872531"/>
    <dbReference type="KEGG" id="ani:ANIA_04734"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN4734"/>
    <dbReference type="eggNOG" id="KOG0527">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_863254_0_0_1"/>
    <dbReference type="InParanoid" id="C8VAU1"/>
    <dbReference type="OMA" id="DYHYTPR"/>
    <dbReference type="OrthoDB" id="6247875at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030437">
        <property type="term" value="P:ascospore formation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd01389">
        <property type="entry name" value="HMG-box_ROX1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.10:FF:000041">
        <property type="entry name" value="HMG box family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050140">
        <property type="entry name" value="SRY-related_HMG-box_TF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270:SF161">
        <property type="entry name" value="SEX-DETERMINING REGION Y PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270">
        <property type="entry name" value="SOX TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HMG box" evidence="6">
        <location>
            <begin position="121"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="4">
        <location>
            <begin position="121"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="87"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="184"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBF76901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="318" mass="35033" checksum="82D775CDE63B77C3" modified="2009-11-03" version="1">MAAVSIAMKSPTQSPDSITELLWKDALRHLGSTNDEVLLPTNVVDIIGQDNVEKIKSRLSALLGAPVVSFVDESINALRVLRTPTFSGSSISVASPSRALDSWPSEPPNKPRPASMKPAKIPRPPNAFILYRQHHYPKVKEARPDLSNNEISVIIGKKWRAEPEEGKLHFKNLAEEFKKKHAEEYPDYQYTPRKPSEKKRRAASRISPKNSKRTVALENPGSMTAPSSNVFTPQMYPGIQNGQLAGAGYIGYLDGLNSMVNTGGLTDEPTNFGTNAFNSLFQQPQSDYGRTALFPQLEFAGPSLGDSLEFPEFAADYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>C8VBI4</accession>
    <name>C8VBI4_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">uridine/cytidine kinase</fullName>
            <ecNumber evidence="2">2.7.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ANIA_07502</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uridine: step 1/1.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.48" evidence="2"/>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF79512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467970.1">
        <property type="nucleotide sequence ID" value="XM_050612005.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VBI4"/>
    <dbReference type="FunCoup" id="C8VBI4">
        <property type="interactions" value="792"/>
    </dbReference>
    <dbReference type="STRING" id="227321.C8VBI4"/>
    <dbReference type="GeneID" id="2869605"/>
    <dbReference type="KEGG" id="ani:ANIA_07502"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN7502"/>
    <dbReference type="eggNOG" id="KOG4203">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021278_0_2_1"/>
    <dbReference type="InParanoid" id="C8VBI4"/>
    <dbReference type="OMA" id="EPQLHCE"/>
    <dbReference type="OrthoDB" id="738517at2759"/>
    <dbReference type="UniPathway" id="UPA00574">
        <property type="reaction ID" value="UER00637"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004849">
        <property type="term" value="F:uridine kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008655">
        <property type="term" value="P:pyrimidine-containing compound salvage"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044206">
        <property type="term" value="P:UMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02023">
        <property type="entry name" value="UMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000106">
        <property type="entry name" value="Uridine kinase, putative (AFU_orthologue AFUA_2G05430)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:004553">
        <property type="entry name" value="Uridine kinase, putative (AFU_orthologue AFUA_2G05430)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006083">
        <property type="entry name" value="PRK/URK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000764">
        <property type="entry name" value="Uridine_kinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10285">
        <property type="entry name" value="URIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00485">
        <property type="entry name" value="PRK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14681">
        <property type="entry name" value="UPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00988">
        <property type="entry name" value="URIDINKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribulokinase/uridine kinase" evidence="6">
        <location>
            <begin position="27"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphoribulokinase/uridine kinase" evidence="6">
        <location>
            <begin position="119"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="7">
        <location>
            <begin position="214"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBF79512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="410" mass="46130" checksum="EF04E85AEA6455C2" modified="2009-11-03" version="1">MESISPVYSAATKSDKRYSPPWADLSIIGIAGSSGSGKTSVAMEIVKSLDLPWVVILVMDSFYKSLNPEQHAKAHRNEFDFDSPDSIDFDVLVQCLRDLKQGIVELLDVKAVELSDGSQIVLRDVKERGRDIDGIIKQWFNYVKPSYKKFVEPQRSVSDIIIPRGIENKTAIGMVVQHIQRMLEEKSERHSATLQELRRITFEEQLSQNVIMMPQTPQSIGMNTILQNPETEQVDFVFYFDRLAALLIEKALDYTSYAPKEVETPQHNMYSGLKQEGIVSAVAILRGGSCLETALKRTIPDCVTGRVLIRTNETKEEPQLHYLKLPPGIEQHSNVMLLDSQMSSGGAALMAVRVLIDHGVPEDRIIFVTCAAVQSGVKRLAAVYPHVKLIVGRIEEESEPRWMEHRYFGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C8VBL0</accession>
    <name>C8VBL0_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Lipase/esterase family protein (AFU_orthologue AFUA_6G09520)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ANIA_07524</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDXG' lipolytic enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF79561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467978.1">
        <property type="nucleotide sequence ID" value="XM_050612015.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VBL0"/>
    <dbReference type="GeneID" id="2869483"/>
    <dbReference type="KEGG" id="ani:ANIA_07524"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN7524"/>
    <dbReference type="eggNOG" id="KOG1515">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004893_0_1_1"/>
    <dbReference type="InParanoid" id="C8VBL0"/>
    <dbReference type="OMA" id="PHWVRTE"/>
    <dbReference type="OrthoDB" id="2336090at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002168">
        <property type="entry name" value="Lipase_GDXG_HIS_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF19">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01173">
        <property type="entry name" value="LIPASE_GDXG_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="257"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="442"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="604"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="722"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="795"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="257"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="446"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="461"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="611"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="666"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="723"/>
            <end position="760"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBF79561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="824" mass="90669" checksum="ECB1049B5DDDC5C4" modified="2009-11-03" version="1">MALSSLSIGVALTPTVVSTLFSHYANRKTLHNKPNVHLSYDEGISVIREFIDFSSKRPIEYIQEFTAQRVPAPHWVRIERVSVAEEFLSESAALIIKQLGPRGVAQVGGEKWWQWRGPSGDKNNGELRGEWIEMHSDYNARKHAAKTDSSNRRIMLYIHGGAYYFGSVQTHRYQLQRHARKLKGRVFARMLVICRDQGLPLPAGAILISPWVDLTHSFPSIVKDNPGDYIPPHGFLHKPSLAWPPPNEDEIREINEALKKNPATTDKKNEKNEPPTGEANVFKVSESEPTLGHGRRPPSFVMNGKTIEVKDQIHMYTTNELLFHPLVSPIFQPSLGGLPPLQIISGGGEMLRDEQFYIAHKAANPVAYPPNDSLLAELDPKREIVNKYPGTYVQLQVWDDLCHVAPILSFTRPAKYMFRSIAQFGAWALARAQDTTVDIVNDDEVSPISSSESASPETSDNEGREKGPHDRPGIAVGKAGDSLPPFKDRMIRQRVDKRGHIYPLPPPRDCPALQLPPSSVGTINPGLLMKWMLVKEEWDQKFAKEKARIHQLRLAGLASGFQDFDGDTPPPSALAARRFSPGALPPKGLRTSYPMTMWARFATKHDKRTIKREQEMDSRSQRSNRASVDAGRAGASIEHQETKDKAASIPTEPAQQLNDKVPYSKPPSNDNKPTDSNPSLAQASSNKSFVPGPFIVLPNYEGPDKSENASTRALFHVPGTIKPTAQTAGTSKSSQDLDQRPSSQGGSATIRSGFTVQSDPVTDDAGSTIGDEKSLAVTTLGGVDAASTRAVLNADGVLRPSTDNNSVYVSADSLPLTNGADHEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>C8VBQ1</accession>
    <name>C8VBQ1_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Threonine aldolase or alanine racemase, putative (Eurofung)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ANIA_07564</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the threonine aldolase family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF79639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_680833.2">
        <property type="nucleotide sequence ID" value="XM_675741.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VBQ1"/>
    <dbReference type="FunCoup" id="C8VBQ1">
        <property type="interactions" value="959"/>
    </dbReference>
    <dbReference type="STRING" id="227321.C8VBQ1"/>
    <dbReference type="GeneID" id="2869744"/>
    <dbReference type="KEGG" id="ani:ANIA_07564"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN7564"/>
    <dbReference type="eggNOG" id="KOG1368">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029381_1_0_1"/>
    <dbReference type="InParanoid" id="C8VBQ1"/>
    <dbReference type="OMA" id="VQTNIVI"/>
    <dbReference type="OrthoDB" id="10261951at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008732">
        <property type="term" value="F:L-allo-threonine aldolase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006545">
        <property type="term" value="P:glycine biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006567">
        <property type="term" value="P:L-threonine catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000030">
        <property type="entry name" value="Low-specificity L-threonine aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000089">
        <property type="entry name" value="Threonine aldolase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001597">
        <property type="entry name" value="ArAA_b-elim_lyase/Thr_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023603">
        <property type="entry name" value="Low_specificity_L-TA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041359">
        <property type="entry name" value="GntG_guanitoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48097:SF9">
        <property type="entry name" value="L-THREONINE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48097">
        <property type="entry name" value="L-THREONINE ALDOLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01212">
        <property type="entry name" value="Beta_elim_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017617">
        <property type="entry name" value="Thr_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aromatic amino acid beta-eliminating lyase/threonine aldolase" evidence="6">
        <location>
            <begin position="56"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="5">
        <location>
            <position position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR017617-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBF79639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="411" mass="45076" checksum="362A73A43566BB51" modified="2009-11-03" version="1">MKRFVRPVLQSSRFFEPVVSPLQARRGLRLVTNMATSNAANGKQTTWHGAGAAEFDLRSDTMTKPTPSMLEAICQTTLLDDVFEEDPVTNELQNYVAKRTNHEAALLVMSGTMGNQVAIRTHLTEPPYSVVCDYRSHIICYEAGGVSAWTGATVIPVIPKNNTYLTLEDVQKKVVISKDVHTCPTKLISLENTLDGMIMPLEEARRITEWAHENGIKVHLDGARLWEAVVSGAGSLPEYSSLFDSISLCFSKGLGAPIGSIIVGSELFIKKARWFRKSIGGGARQTGVLAAAARVALDETFGLDPSGKDGKLRETHIKAKRVADMWTKRGGKLAYPVQTNMVWLDTEASGLGPNDLAETGKEKGLKLLGHRIVIHYQVSEDAIDRLEQVFDLVLTGQHQQSTDTSKPYGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>C8VC67</accession>
    <name>C8VC67_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein bL33m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ANIA_11568</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial ribosomal protein bL33 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF79579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467981.1">
        <property type="nucleotide sequence ID" value="XM_050612018.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VC67"/>
    <dbReference type="FunCoup" id="C8VC67">
        <property type="interactions" value="212"/>
    </dbReference>
    <dbReference type="STRING" id="227321.C8VC67"/>
    <dbReference type="GeneID" id="74897135"/>
    <dbReference type="KEGG" id="ani:ANIA_11568"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN11568"/>
    <dbReference type="eggNOG" id="ENOG502S7R4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_190949_1_2_1"/>
    <dbReference type="InParanoid" id="C8VC67"/>
    <dbReference type="OMA" id="TCFNVKR"/>
    <dbReference type="OrthoDB" id="275534at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.120">
        <property type="entry name" value="Ribosomal protein L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052008">
        <property type="entry name" value="Mitoribosomal_protein_bL33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001705">
        <property type="entry name" value="Ribosomal_bL33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038584">
        <property type="entry name" value="Ribosomal_bL33_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01023">
        <property type="entry name" value="rpmG_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47037">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L33, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47037:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL33M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00471">
        <property type="entry name" value="Ribosomal_L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBF79579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="60" mass="6872" checksum="13C423CFEA6679DA" modified="2009-11-03" version="1">MAKKAKSRTMAVRLISMAMTGYYRTMTRPRAHRPLSMLKYDPVVKKKVLFLEATKGGRAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>C8VCS2</accession>
    <name>C8VCS2_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CAF1 family ribonuclease, putative (AFU_orthologue AFUA_2G16960)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ANIA_10928</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF78697.1"/>
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        <property type="nucleotide sequence ID" value="XM_675461.2"/>
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    <dbReference type="AlphaFoldDB" id="C8VCS2"/>
    <dbReference type="STRING" id="227321.C8VCS2"/>
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    <dbReference type="VEuPathDB" id="FungiDB:AN10928"/>
    <dbReference type="eggNOG" id="KOG1990">
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    <dbReference type="OMA" id="MNIGIAN"/>
    <dbReference type="OrthoDB" id="414075at2759"/>
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        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006941">
        <property type="entry name" value="RNase_CAF1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04857">
        <property type="entry name" value="CAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF78697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="346" mass="39632" checksum="0B686393D8C1B49B" modified="2009-11-03" version="1">MDVDETDYESLALLKFVRKLIDEWIALGDIKKRDKYLKIPPPSRQKETQTLDSVPSILNRFQKRLVHQVVEVEYPDFVTIGRPGFVQIIDYDEKREVAVRDKRVQWCQKRVRKQTGFRWIAEALAWGDLTHLSTNYFPGVRGNTASTEQGKSLQEFVENFKARLKAHRPILVGHNLFTDLVYFFRCFFWNPTEPCRGLSVHGAQAFSYCHRYKTDLFRHTSSFRQIFVKLSAQLGSGSQIRPAGSPSNTSLTAAHGLNNRFSHLHVEETSNGLASPLVVAESERSDGVLGQQSHAEEIRLAEKGLLISRPNFQFWRVYGNNLRNFGTKEKNLQNMKRAIGMCAASI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>C8VDJ9</accession>
    <name>C8VDJ9_EMENI</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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    <gene>
        <name evidence="1" type="ORF">ANIA_11571</name>
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    <organism evidence="1 2">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF79997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468032.1">
        <property type="nucleotide sequence ID" value="XM_050612074.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VDJ9"/>
    <dbReference type="GeneID" id="74897137"/>
    <dbReference type="KEGG" id="ani:ANIA_11571"/>
    <dbReference type="HOGENOM" id="CLU_2793957_0_0_1"/>
    <dbReference type="InParanoid" id="C8VDJ9"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF79997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="68" mass="7447" checksum="D533337C340B32FB" modified="2009-11-03" version="1">MSYWRQPTIGSHLSGFTRGADPAIVQLLLENGADPNIKKPRSTVCPKGSAISIWVLQRHDQATKVMTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>C8VE72</accession>
    <name>C8VE72_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ANIA_11605</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF80413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468078.1">
        <property type="nucleotide sequence ID" value="XM_050612125.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VE72"/>
    <dbReference type="STRING" id="227321.C8VE72"/>
    <dbReference type="GeneID" id="74897166"/>
    <dbReference type="KEGG" id="ani:ANIA_11605"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN11605"/>
    <dbReference type="HOGENOM" id="CLU_2497886_0_0_1"/>
    <dbReference type="InParanoid" id="C8VE72"/>
    <dbReference type="OrthoDB" id="8300214at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF80413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="86" mass="9719" checksum="B589E69C7A616E17" modified="2009-11-03" version="1">MKYSIDHLARGIQESNTLSLHTPTIKEAASRAGWRVQKENHVENHPDALDGKRAVDDVLSEAFRTAIAVEPDGRRRRIAEVGLWFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>C8VFH7</accession>
    <name>C8VFH7_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Geranylgeranyl transferase beta subunit, putative (AFU_orthologue AFUA_6G06710)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ANIA_05760</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein prenyltransferase subunit beta family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF81258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468194.1">
        <property type="nucleotide sequence ID" value="XM_050612252.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VFH7"/>
    <dbReference type="FunCoup" id="C8VFH7">
        <property type="interactions" value="4"/>
    </dbReference>
    <dbReference type="STRING" id="227321.C8VFH7"/>
    <dbReference type="GeneID" id="2872052"/>
    <dbReference type="KEGG" id="ani:ANIA_05760"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN5760"/>
    <dbReference type="eggNOG" id="KOG0367">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028946_2_0_1"/>
    <dbReference type="InParanoid" id="C8VFH7"/>
    <dbReference type="OMA" id="RWCLMRQ"/>
    <dbReference type="OrthoDB" id="24893at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005953">
        <property type="term" value="C:CAAX-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008318">
        <property type="term" value="F:protein prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000032">
        <property type="entry name" value="Putative geranylgeranyl transferase beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045089">
        <property type="entry name" value="PGGT1B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001330">
        <property type="entry name" value="Prenyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774:SF4">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE-1 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00432">
        <property type="entry name" value="Prenyltrans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Prenyltransferase alpha-alpha toroid" evidence="9">
        <location>
            <begin position="6"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="Prenyltransferase alpha-alpha toroid" evidence="9">
        <location>
            <begin position="208"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="275"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="277"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBF81258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="446" mass="50026" checksum="1A94AD6051326F6B" modified="2009-11-03" version="1">MSEAVFTKDRHVTFFLRCLKTFLPGLYTSNDSNRMLLAFFIVAGLDLLGALESKTTPEERQGYIEWIYQCQVPSGGFRGFTGTDFGTELRTPENEAWDPANVPSTFFALVILLILGDDLSRVKRTECLKWLRKMQRPNGSFGEVLGPDESVEGGGDLRFCCFAAGTRYILRGRRDTGLDGIEDIDVGKLVAFIVSCQVRFYNPLYVIFTESVQAYDGGMAEGPYCEAHSGHTYCAVNTLTFLNRVSDDSWRVPLVSPGSHQFESLVRWLVSRQTNELGDEDEDEDEDEDDEKEEDDVDDSNSPTNVVQGLSEAVNELDLNNSIDALPIILPPGEESLQWAGFNGRCNKYADTCYSFWNAATLDMLGRLSMVDAERNRRYLLQKTQHLVGGFGKSVGELPDLLHSYFGMVSLAFQGEQGLDSVDSALCATHRTVRRLHSLPWWQENE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>C8VHI0</accession>
    <name>C8VHI0_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ANIA_11355</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF84333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468579.1">
        <property type="nucleotide sequence ID" value="XM_050612688.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VHI0"/>
    <dbReference type="GeneID" id="74896955"/>
    <dbReference type="KEGG" id="ani:ANIA_11355"/>
    <dbReference type="HOGENOM" id="CLU_2399671_0_0_1"/>
    <dbReference type="InParanoid" id="C8VHI0"/>
    <dbReference type="OrthoDB" id="3268409at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF84333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="93" mass="11010" checksum="AAF3BDC9C16C28DA" modified="2009-11-03" version="1">MNILSIMCEKSIMKAKLFQSLCSFEVDMSFKRRIMEKAVPTIFYFKKVFEIIHDLSGYLVQFFYLHRTGIETIIVDMDEGQRDVRFGKMPTRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2025-10-08" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>C8VHU0</accession>
    <name>C8VHU0_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Short-chain dehydrogenase/reductase, putative (AFU_orthologue AFUA_6G03370)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ANIA_10399</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF82890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_660954.2">
        <property type="nucleotide sequence ID" value="XM_655862.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VHU0"/>
    <dbReference type="FunCoup" id="C8VHU0">
        <property type="interactions" value="252"/>
    </dbReference>
    <dbReference type="GeneID" id="2873745"/>
    <dbReference type="KEGG" id="ani:ANIA_10399"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN10399"/>
    <dbReference type="eggNOG" id="KOG1209">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_2_9_1"/>
    <dbReference type="InParanoid" id="C8VHU0"/>
    <dbReference type="OMA" id="INVWGPL"/>
    <dbReference type="OrthoDB" id="2102561at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05374">
        <property type="entry name" value="17beta-HSD-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44169">
        <property type="entry name" value="NADPH-DEPENDENT 1-ACYLDIHYDROXYACETONE PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44169:SF6">
        <property type="entry name" value="NADPH-DEPENDENT 1-ACYLDIHYDROXYACETONE PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBF82890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="285" mass="30942" checksum="251E86EAA78DB0E3" modified="2009-11-03" version="1">MASRKTVLITGCSDDGIGSGLALTFQQRDYHVFATARNIQKMSKLHGLPNVTLLTLDVCNKDHITAAVEAVTKHTGGKLDYLVNNAGRNHFMPILDEDIEVTKKLYETNVWGPVALTQAFAPLLIAARGTIAFITSIAGYLNVPYMGTYAGSKRSIELIAETLRLELAPFHVRVLSVVTGAVKTMGQTYFGDFKLPEDSLYKPIEQTIASRAQGGDGNAREDLMTYSKKVVTEITNGSSSKFWCGSGAGMLRFSTSFLPGSFLDNAVSRNTDLDVLAANLNKKHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>C8VI41</accession>
    <name>C8VI41_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_03262</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF83076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468421.1">
        <property type="nucleotide sequence ID" value="XM_050612507.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VI41"/>
    <dbReference type="GeneID" id="2874243"/>
    <dbReference type="KEGG" id="ani:ANIA_03262"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN3262"/>
    <dbReference type="eggNOG" id="ENOG502QWJP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023751_4_1_1"/>
    <dbReference type="InParanoid" id="C8VI41"/>
    <dbReference type="OMA" id="RAVMIMP"/>
    <dbReference type="OrthoDB" id="2019572at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35560">
        <property type="entry name" value="BLL0132 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35560:SF3">
        <property type="entry name" value="PEPTIDASE S9 PROLYL OLIGOPEPTIDASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002993404" evidence="1">
        <location>
            <begin position="19"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF83076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="392" mass="43547" checksum="167409BED5C8F3E1" modified="2009-11-03" version="1">MRLVYLVLALSTAAMSRASVPPEYLQANHKNGDPPPFGAVDDVQTIRLSGQPDAVGETQPADCPTIMISTATPGGDHINGWKEIPVVAGFDLKRLVVDEDMNATLPYYIENTKDLIQITRVVITTAGIWRNGWKYANNIRNSLICAAGRESVNADMSKILVACPQWLNKEDVAAGAAEPNDIYYHKNTYQRGGPAVGPGQVKISSFEALDKFIAIFWNKDVYPALETIVFASHYAMLRPSQPEDSQITYGVMNPGSFAWLVSDRPVFPTDITCADPSVYDAWYFGIGPGKPKRIPKYVRDEVINNRTFVEGRYTSRNVFYGFGLDDHGKGDTHCEAQMQGASHLERGQNFMKMLEGLPGGFPVNHSVDYIEGISHLDYHMMVSEPMQRKMFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>C8VIR1</accession>
    <name>C8VIR1_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ANIA_03062</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF83478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_660666.2">
        <property type="nucleotide sequence ID" value="XM_655574.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VIR1"/>
    <dbReference type="STRING" id="227321.C8VIR1"/>
    <dbReference type="GeneID" id="2874500"/>
    <dbReference type="KEGG" id="ani:ANIA_03062"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN3062"/>
    <dbReference type="eggNOG" id="ENOG502R0AV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002168_0_0_1"/>
    <dbReference type="InParanoid" id="C8VIR1"/>
    <dbReference type="OMA" id="FIAVYQH"/>
    <dbReference type="OrthoDB" id="10255000at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051417">
        <property type="term" value="P:microtubule nucleation by spindle pole body"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007097">
        <property type="term" value="P:nuclear migration"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012943">
        <property type="entry name" value="Cnn_1N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019528">
        <property type="entry name" value="PACT_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47357">
        <property type="entry name" value="COP1-INTERACTIVE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47357:SF1">
        <property type="entry name" value="SPINDLE POLE BODY COMPONENT 110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07989">
        <property type="entry name" value="Cnn_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10495">
        <property type="entry name" value="PACT_coil_coil"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Centrosomin N-terminal motif 1" evidence="8">
        <location>
            <begin position="194"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="Pericentrin/AKAP-450 centrosomal targeting" evidence="9">
        <location>
            <begin position="1105"/>
            <end position="1181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="113"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="155"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="372"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="433"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="662"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="935"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="67"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="380"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="433"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="456"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBF83478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="1207" mass="139549" checksum="FBEDF96B7AF8C4AB" modified="2009-11-03" version="1">MAYPYIDTPRTEVDGNATYLTNGYRSVGRHNLSALDSVENSFQTPSKDEDVLKVLGDGRGRSFAGSKLNTPRATAGTKSTRSALNSRQLPTMGAKGEFTPMLKSAMKNNYMKNVSTTRGTGGPKTPSYARGGYRSNGNTPGLTVMEMTGIDEEDATADEPTPVPQVASSSVAGTPLPGLTSRDNGVLGDGSNMTLKEQEKIIDKLDKDNFGLKLKIHFLQEQLEKAGPAYNQAALHENTELKISKLTMQRDISRYKKSLQQAERDLEAYRQQFQDFKEKMRRKHTDETIQREMEDQRVKELQEQLREARDSRSEEIDKLRDDIEDLEASLREKDRTIEEREEEIEELKDRDSQEKDSLSELETELRRAKEQLEELQDSLDQAKSDAIEARTSERQALEEKERAEQNLQELHDEMSNKSISTKGLTRQLEEEVKELRQRNSTLKEELESKTQQMNDLEERLQNSRETTDSERERLLEELTQVRREREVARQERDDLNVQLQEAHDELQRKTDEKALLHTRHHALTDESSNLQNELAKAQSNIRELQESLDTVKQNAAENAENLRSQYMEDIERLQEEIESLHHEIEDKEGQFALEQDRWESLRRNLQVQKDRAEDQAAGFKRTIEKLEQVEHTLTGKESKLQEVIDSEKARHFNAEAVLSRQVKELNDDLSAKRDAIDELRHELLSVKEELRLARRAEATLKEKVQSLEDEVVVLQSSLEEEQEYTKAHTRKGPVEQESQVQKLLADKQKLRDQLANAHVELHDLKTVKAEIEAERDELQAQLEQVQNQVSDTRFDKEKTELRKASLRMETELKRLKEDKMSLLETKESLENQLNSEIERAALEENRLSAEIDQLQTKLQSASGGRDRELALTKSKLQRFERRIHELEERLEQQPPANQEQSATAADLSMLRHSLDEVRKREKALIQRETDQKASIRAYKTKIVELERELHDATIKKFETQSPSSSPANKLQQDVRTLRKQLSDAHRALRELKSKNHDLERAAMREEDQRDLHELLKQSTLEAESLALQVSEKEAQLNDAESRIRRVREERASYARKANAALKELDTLQDRYKQTMEKARAKGENKTKHEKEMLGLGKEILWLRARLKREEKFRRDLAWGKGLMELGERVRIACNEADLRMISDMGVIARDRSNLRSPKAKLKTAVSMVKAVVRMQKMSREWKKTTKLGEGLKRAKNEVMKRRELSKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>C8VJZ3</accession>
    <name>C8VJZ3_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 14">Uroporphyrinogen decarboxylase</fullName>
            <ecNumber evidence="4 14">4.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">ANIA_02733</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="19">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the sequential decarboxylation of four acetate groups of uroporphyrinogen-III (octacarboxyporphyrin) to yield coproporphyrinogen-III (tetracarboxyporphyrin) with the formation of intermediate hepta-, hexa- and penta-carboxylate porphyrinogens in the heme biosynthesis pathway. Acts on a number of porphyrinogens, but only coproporphyrinogen III can ultimately be converted to heme.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>uroporphyrinogen I + 4 H(+) = coproporphyrinogen I + 4 CO2</text>
            <dbReference type="Rhea" id="RHEA:31239"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:62626"/>
            <dbReference type="ChEBI" id="CHEBI:62631"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 14">
            <text>uroporphyrinogen III + 4 H(+) = coproporphyrinogen III + 4 CO2</text>
            <dbReference type="Rhea" id="RHEA:19865"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57308"/>
            <dbReference type="ChEBI" id="CHEBI:57309"/>
            <dbReference type="EC" id="4.1.1.37"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the uroporphyrinogen decarboxylase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.37" evidence="4 14"/>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF84124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468557.1">
        <property type="nucleotide sequence ID" value="XM_050612662.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VJZ3"/>
    <dbReference type="SMR" id="C8VJZ3"/>
    <dbReference type="FunCoup" id="C8VJZ3">
        <property type="interactions" value="889"/>
    </dbReference>
    <dbReference type="STRING" id="227321.C8VJZ3"/>
    <dbReference type="GeneID" id="2873887"/>
    <dbReference type="KEGG" id="ani:ANIA_02733"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN2733"/>
    <dbReference type="eggNOG" id="KOG2872">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040933_0_0_1"/>
    <dbReference type="InParanoid" id="C8VJZ3"/>
    <dbReference type="OMA" id="LWLMRQA"/>
    <dbReference type="OrthoDB" id="339900at2759"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00321"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004853">
        <property type="term" value="F:uroporphyrinogen decarboxylase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006783">
        <property type="term" value="P:heme biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00717">
        <property type="entry name" value="URO-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.210:FF:000004">
        <property type="entry name" value="Uroporphyrinogen decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00218">
        <property type="entry name" value="URO_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006361">
        <property type="entry name" value="Uroporphyrinogen_deCO2ase_HemE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000257">
        <property type="entry name" value="Uroporphyrinogen_deCOase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01464">
        <property type="entry name" value="hemE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21091">
        <property type="entry name" value="METHYLTETRAHYDROFOLATE:HOMOCYSTEINE METHYLTRANSFERASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21091:SF169">
        <property type="entry name" value="UROPORPHYRINOGEN DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01208">
        <property type="entry name" value="URO-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="UROD/MetE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00906">
        <property type="entry name" value="UROD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00907">
        <property type="entry name" value="UROD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 14" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="8" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="9 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="10 14" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uroporphyrinogen decarboxylase (URO-D)" evidence="16">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="Uroporphyrinogen decarboxylase (URO-D)" evidence="17">
        <location>
            <begin position="150"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00058098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS00907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CBF84124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="363" mass="40711" checksum="BEB716DA87E210BF" modified="2009-11-03" version="1">MTQFAPLKNDLLLRAAWGDKVHRPPIWVMRQAGRYLPEYHEAKGNRDFFECCRDPEIASTITIQPVDRYEGLIDAAIIFSDILVIPQAMGMTVEMVDKKGPHFPEPLRSPTDGQYEKVMARDVDVKAELDYVYKAITLTRTKLNGRVPLIGFCGAPWTLLCYMVEGGGSKMFIQTKTWIYKYPKESQALLQKIAEICVEYLALQVAAGAQLVQVFDSWAGELSPASFQDFSLPYLRHISANLPRRLKEMGLEPVPMTVFAKGAWYALEDLCESGYNVVGLDWLHDPAEAFKIANGRVTIQGNADPGVLYGGREAIKQAVETMVAGFKKGKQGWIANLGHGVTPFVNPDDLKFYFEEIHRLTAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>C8VKC7</accession>
    <name>C8VKC7_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transcription factor with C2H2 and Zn(2)-Cys(6) DNA binding domain (Eurofung)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ANIA_10334</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF84202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468564.1">
        <property type="nucleotide sequence ID" value="XM_050612669.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VKC7"/>
    <dbReference type="GeneID" id="74896344"/>
    <dbReference type="KEGG" id="ani:ANIA_10334"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN10334"/>
    <dbReference type="eggNOG" id="KOG0773">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020539_0_0_1"/>
    <dbReference type="InParanoid" id="C8VKC7"/>
    <dbReference type="OMA" id="LDSWVCT"/>
    <dbReference type="OrthoDB" id="10056939at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008422">
        <property type="entry name" value="KN_HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050224">
        <property type="entry name" value="TALE_homeobox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11850">
        <property type="entry name" value="HOMEOBOX PROTEIN TRANSCRIPTION FACTORS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05920">
        <property type="entry name" value="Homeobox_KN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 5" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Homeobox" evidence="7">
        <location>
            <begin position="216"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="415"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="218"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="274"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="372"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="372"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="393"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBF84202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="593" mass="66298" checksum="B21B5311E95D46D1" modified="2009-11-03" version="1">MENRVAPYGSFMSLQHLQAEDERGVTAPAAPAGGGWPTEEDIFFDWELYGIQDPSCNPEFLPYEQASRSTGTLDFTATQFEPQRASLSGGDSASAIASNPEPEGWGCLQVGPGTTSTPIVPSGFNNVAEWLDGAYRPPTPCDHCRRHRLQCLVLRRTSHNPNPVPSCSSCVGLFRPCSFGRGEKRQPSGFETLSPVLGHLHGVIEEGNENECGERKLDSKESKQFVRKGARVLRDWFYQNEHCPYPSEEEKARLAAETGFSRQRISTWFANARRRHKQQKQARTSTRVFRAGSPMPTSELASMTPMERWQASPPDEEPVSEAMIREAIATSSGSDVSGCRSRFESPLTDFSSGLEGSSLASSVSSFGVLASDASDSSSSAWSYKSGDGPLRPRPYRRPSSGRRGGRKRVTEDGHYQCTFCMQSFKKKHDWSRHEKSVHLPLDVWICTPNLSELEDTNIPFGKCRFCDHQSSSPEHWESHDFRECASKPLPERSFSRKDYLWQHLRKFHGCTRYPVPNLEAWRSAQTDIQSRCGFCAASLPSWSARADHLAIHFKDGCRMSQWAGDWGFEFSVLANLRNAVLPMERSLLSMAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>C8VLJ4</accession>
    <name>C8VLJ4_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Zn(II)2Cys6 transcription factor (Eurofung)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ANIA_08918</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF84660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_682187.2">
        <property type="nucleotide sequence ID" value="XM_677095.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VLJ4"/>
    <dbReference type="STRING" id="227321.C8VLJ4"/>
    <dbReference type="GeneID" id="2868234"/>
    <dbReference type="KEGG" id="ani:ANIA_08918"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN8918"/>
    <dbReference type="eggNOG" id="ENOG502SK4D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014095_0_0_1"/>
    <dbReference type="InParanoid" id="C8VLJ4"/>
    <dbReference type="OMA" id="YPFTNLW"/>
    <dbReference type="OrthoDB" id="1747771at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004507">
        <property type="entry name" value="UbiX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43374">
        <property type="entry name" value="FLAVIN PRENYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43374:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="28"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="68"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="125"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="76"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBF84660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="618" mass="68399" checksum="37BD78AB5F27EA0A" modified="2009-11-03" version="1">MPEPHYPYDTTVVSELLKQKRKARGIKACFPCRHRKVRCDGHVPCASCIKRGHSELCRVPTSSTSAAGFMQGQGQGNNKSTSVLSRPESLSSPQDDPADEQQDAAAAQSPVCDSPSIQYRAQPNLASLLSRMEEIEQQIVSLQKDLRATISIPLAGRLSSVDQPSIGHSAAQAGPQGKSPGRHVVEEATGATIFLGSHSDAPLALGCRETSASGLGSRMLDEVTMAQFVPRAYPFTSLWGPDATVEEVCETLPEEADLIRYWQAYQSTAYPFYPVLVDVEGFGLSVFEFLNTRASQNATEPNPSWLALLFAVLACGAQFTHDPVQERDLRSKVFTCSSFHCLRMSNFFYHTDLDQIQAMALICHCLRNNLDTNTAWILMGTTMRLAQSIGLHEISPTLPPKEQLRQSRLWWTLIWQDTFLSFTYDRPPSSSTAECCTIPRISESPGLSFQECVFKICQIISNQSQLKGEHSALDYKTELESVLNEASLFLTNKVHCRSLQDHLERLALSIHVGYAICRMSQIHLDSMPENSSSAVAADSQRQAMQVVENFLELHRLCGTVCRSWAFVHNAVSCAITMHNLAYVTGDGLADSNTLAHRLMKLLESEARASEWYDADTNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>C8VMC4</accession>
    <name>C8VMC4_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3</fullName>
            <ecNumber evidence="6">2.4.99.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">ANIA_01455</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="25" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="25">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Catalytic subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. This subunit contains the active site and the acceptor peptide and donor lipid-linked oligosaccharide (LLO) binding pockets.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a di-trans,poly-cis-dolichyl diphosphooligosaccharide + L-asparaginyl-[protein] = N(4)-(oligosaccharide-(1-&gt;4)-N-acetyl-beta-D-glucosaminyl-(1-&gt;4)-N-acetyl-beta-D-glucosaminyl)-L-asparaginyl-[protein] + a di-trans,poly-cis-dolichyl diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22980"/>
            <dbReference type="Rhea" id="RHEA-COMP:12804"/>
            <dbReference type="Rhea" id="RHEA-COMP:12805"/>
            <dbReference type="Rhea" id="RHEA-COMP:19506"/>
            <dbReference type="Rhea" id="RHEA-COMP:19509"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:50347"/>
            <dbReference type="ChEBI" id="CHEBI:57497"/>
            <dbReference type="ChEBI" id="CHEBI:57570"/>
            <dbReference type="ChEBI" id="CHEBI:132529"/>
            <dbReference type="EC" id="2.4.99.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the STT3 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.99.18" evidence="6"/>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF84893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468641.1">
        <property type="nucleotide sequence ID" value="XM_050612761.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VMC4"/>
    <dbReference type="FunCoup" id="C8VMC4">
        <property type="interactions" value="968"/>
    </dbReference>
    <dbReference type="STRING" id="227321.C8VMC4"/>
    <dbReference type="GeneID" id="2875377"/>
    <dbReference type="KEGG" id="ani:ANIA_01455"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN1455"/>
    <dbReference type="eggNOG" id="KOG2292">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009279_1_0_1"/>
    <dbReference type="InParanoid" id="C8VMC4"/>
    <dbReference type="OMA" id="TWYAIGT"/>
    <dbReference type="OrthoDB" id="10261066at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004579">
        <property type="term" value="F:dolichyl-diphosphooligosaccharide-protein glycotransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043687">
        <property type="term" value="P:post-translational protein modification"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12610:FF:000001">
        <property type="entry name" value="Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003674">
        <property type="entry name" value="Oligo_trans_STT3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048999">
        <property type="entry name" value="STT3-PglB_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048307">
        <property type="entry name" value="STT3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13872">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13872:SF1">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT STT3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02516">
        <property type="entry name" value="STT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21436">
        <property type="entry name" value="STT3-PglB_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="16" id="KW-0464">Manganese</keyword>
    <keyword evidence="14 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 21" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="91"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="175"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="211"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="273"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="303"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="365"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="391"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="415"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="Oligosaccharyl transferase STT3 N-terminal" evidence="22">
        <location>
            <begin position="22"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="STT3/PglB/AglB core" evidence="23">
        <location>
            <begin position="536"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="718"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="20">
        <location>
            <begin position="724"/>
            <end position="741"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00059243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00067960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF02516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF21436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="CBF84893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="741" mass="83193" checksum="CB6CBC46D1CC9226" modified="2009-11-03" version="1">MAESPVDVLLKGSSGRSARGLLRIIILVTIAAAAVSSRLFSVIRFESIIHEFDPWFNFRATKYLVQNGFYDFWDWFDDRTWHPLGRVTGGTLYPGLMVTSGVIYHILRFLTFPVDIRNICVLLAPGFSGLTAFAMYLLTNEMSSSPSAGLLAAAFMGIAPGYISRSVAGSYDNEAIAIFLLVFTFFLWIKAVKNGSIMWGALAALFYGYMVSAWGGYVFITNLIPLHVFVLLCMGRYSPRLYISYTTWYALGTLASMQIPFVGFLPIRNSDHMSALGVFGLLQLVAFAEFVRSYIPGKQFQRLLTASIILITGLAFAGLVVLSMSGIIAPWSGRFYSLWDTGYAKIHIPIIASVSEHQPTAWPSFFFDLNFLIWLFPAGVYMCFRDLRDEHVFVIIYAVLASYFAGVMVRLMLTLTPIVCVAAALVLSYILDTYLKTSPGPVTRGRSNDESSEGLRSARSPEVGITSYFSKAVTTSAAIVYLLLFVAHCTWVTSNAYSSPSVVLASRMPDGSQFIIDDYREAYYWLRQNTPANAKIMSWWDYGYQIGGMADRPTLVDNNTWNNTHIATVGKAMSSREEVSYPILRQHDVDYVLVVFGGLLGYSGDDINKFLWMVRIAEGIWPDEVKERDFFTARGEYRVDDQATPTMRNSLMYKMSYHNFNKLFPMGQATDRVRGAKLPAESPQLSTLEEAFTSENWIIRIYKVKDLDNLGRDHSNAVAFDRGNKRKKASKRKGPRVLRSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>C8VMW9</accession>
    <name>C8VMW9_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nonsense-mediated mRNA decay factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ANIA_02271</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays a role in nonsense-mediated mRNA decay.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF86507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468849.1">
        <property type="nucleotide sequence ID" value="XM_050613004.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VMW9"/>
    <dbReference type="FunCoup" id="C8VMW9">
        <property type="interactions" value="167"/>
    </dbReference>
    <dbReference type="STRING" id="227321.C8VMW9"/>
    <dbReference type="GeneID" id="2874844"/>
    <dbReference type="KEGG" id="ani:ANIA_02271"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN2271"/>
    <dbReference type="eggNOG" id="KOG2162">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013363_1_0_1"/>
    <dbReference type="InParanoid" id="C8VMW9"/>
    <dbReference type="OMA" id="QTPPCGQ"/>
    <dbReference type="OrthoDB" id="69928at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018834">
        <property type="entry name" value="DNA/RNA-bd_Est1-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019458">
        <property type="entry name" value="Est1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045153">
        <property type="entry name" value="Est1/Ebs1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15696:SF36">
        <property type="entry name" value="NONSENSE-MEDIATED MRNA DECAY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15696">
        <property type="entry name" value="SMG-7 SUPPRESSOR WITH MORPHOLOGICAL EFFECT ON GENITALIA PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10374">
        <property type="entry name" value="EST1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10373">
        <property type="entry name" value="EST1_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0866">Nonsense-mediated mRNA decay</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Telomerase activating protein Est1-like N-terminal" evidence="4">
        <location>
            <begin position="59"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="DNA/RNA-binding" evidence="3">
        <location>
            <begin position="190"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="628"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="777"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="829"/>
            <end position="857"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU369098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBF86507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="857" mass="95128" checksum="224D6C62B5CDF451" modified="2009-11-03" version="1">MALTFQNAWQSALNVEKALLNNLAEKEPTFAEISHNISELRTACQNAILQDFETARSIDVEGRLWDAHLKINTRFRKLLSRFRDDNEKKKKPVERRKFEKHYLEFIKSSQRFYRGYIQQLASHFGGISELEKVARKFNFDDLSAAPPIQTSESLRKSILRSCHATLVRLGDLSRYRETELVSKERNWGPAIGYYDLASVIYPASGASHNQLAVIALADANHLKATYHLYRALSAQEPHPTARGNLEIEFRKVLSLWAKGELIRRDDAGTPGRSLAPLFVYLHAQCYRGVDFPEHDELESEVLNQLAVDLKERSLEGILQKFCLINIAAEDSSRTRSDERPKTNAHLFFQRINVKTYFTLLQILLAEVERFVVEDSSSNNSKNKVGADKITVVVRRILPALRNYSSWLLTVSNYLVAYKEKDTPLAVQLTEFWKIYANTLTLLASTFDVVHLPEVDYLLEEDEETLCFMPLSKGATSRRYLDVNGQRKPSMNDPGIERNHPNIEMLSRIREFVIDGLDLVVGNKIPVALVDDEDKKTFIYKEDGLPSQFFASPTGHHHSLSTASIEREDIRQVKQEANYQIDARSTFGGSQSASVSMSAAMNGIVEGVERLVESDTYENAPVIPNRSFDAISNTVPRDDKLPARQTPVAPPGLGPPMTSYSAALPQVSSSQSFTPQAAIPGLPTIWSTGTFSPEFRDVSSHTASGLGLLNAQGPKVTGNANSPGLQYVPESAVKSESISRQSLFAESQLEGTTFNNGPVSPFLAPSMYHQRFSGSSWDRDGIGAPASQQQALPRSTGFGLASQPMSSGFTNNTWANNAFIGSTITSGYGSYPGLDDARKTPSAQYGAIGQSPRLGQSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>C8VN06</accession>
    <name>C8VN06_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ANIA_01566</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
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        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
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                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
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            <dbReference type="DOI" id="10.1038/nature04341"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
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    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
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                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
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                <person name="Visser J."/>
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            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="CBF86698.1"/>
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    </evidence>
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        <source>
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    </evidence>
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        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
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                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
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                <person name="Asai K."/>
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                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
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            <dbReference type="DOI" id="10.1038/nature04341"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
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    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
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                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
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                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
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                <person name="Xiang X."/>
                <person name="Xiong Y."/>
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                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
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        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
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    </reference>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF85364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="85" mass="10249" checksum="C67FA235D7D3115B" modified="2009-11-03" version="1">MFSRTRPQLSQRPRVVVDPHLHPEPRRRTPPITDIRQTNEYKAAARRWISTIVALPILMYTSWVLYERTYGNKQPKRLRDHVQQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>C8VPA8</accession>
    <name>C8VPA8_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Profilin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ANIA_02484</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the profilin family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF86948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_660088.2">
        <property type="nucleotide sequence ID" value="XM_654996.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VPA8"/>
    <dbReference type="FunCoup" id="C8VPA8">
        <property type="interactions" value="272"/>
    </dbReference>
    <dbReference type="STRING" id="227321.C8VPA8"/>
    <dbReference type="GeneID" id="2875189"/>
    <dbReference type="KEGG" id="ani:ANIA_02484"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN2484"/>
    <dbReference type="eggNOG" id="KOG1755">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_120772_1_1_1"/>
    <dbReference type="InParanoid" id="C8VPA8"/>
    <dbReference type="OMA" id="HHAENVQ"/>
    <dbReference type="OrthoDB" id="421374at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051285">
        <property type="term" value="C:cell cortex of cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031097">
        <property type="term" value="C:medial cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003785">
        <property type="term" value="F:actin monomer binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044396">
        <property type="term" value="P:actin cortical patch organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030041">
        <property type="term" value="P:actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000755">
        <property type="term" value="P:cytogamy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903475">
        <property type="term" value="P:mitotic actomyosin contractile ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00148">
        <property type="entry name" value="PROF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.30:FF:000015">
        <property type="entry name" value="Profilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.30">
        <property type="entry name" value="Dynein light chain 2a, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048278">
        <property type="entry name" value="PFN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005455">
        <property type="entry name" value="PFN_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036140">
        <property type="entry name" value="PFN_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11604">
        <property type="entry name" value="PROFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11604:SF0">
        <property type="entry name" value="PROFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00235">
        <property type="entry name" value="Profilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00392">
        <property type="entry name" value="PROFILIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00392">
        <property type="entry name" value="PROF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55770">
        <property type="entry name" value="Profilin (actin-binding protein)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBF86948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="131" mass="13652" checksum="1D1031326F98F9F1" modified="2009-11-03" version="1">MGAHSAVWQQYVDSSLMGSGQFDKAAILSPDFSGVEASSPGFTISPQEIQGIGSAFGDSTWAMQNGVTIGGEKFLAIKADDQSVYGKKGKEGVVIVRTPSCIMIGHHTEAVQTTNAAAAIEKVGDYLRGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>C8VQB9</accession>
    <name>C8VQB9_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ANIA_11223</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF87302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468955.1">
        <property type="nucleotide sequence ID" value="XM_050613115.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VQB9"/>
    <dbReference type="STRING" id="227321.C8VQB9"/>
    <dbReference type="GeneID" id="74896851"/>
    <dbReference type="KEGG" id="ani:ANIA_11223"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN11223"/>
    <dbReference type="HOGENOM" id="CLU_692677_0_0_1"/>
    <dbReference type="InParanoid" id="C8VQB9"/>
    <dbReference type="OrthoDB" id="39175at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF6">
        <property type="entry name" value="PROLINE UTILIZATION TRANS-ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBF87302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="398" mass="43946" checksum="4353767D8C44A6A4" modified="2009-11-03" version="1">MTRPLCASGIYCGLETVHGASPSPVPIPVSERVRKTDCCTKPCTRRRRHVAASRSWACLYYAVVAVGCQHCDGGSYEARTGSAWAYFEQAMNYSQDLHFPVSLTLVQALVALVSTLSLPQGVQSTKNSAIAEQGLLESETDPLGAFLSINSGIWPQAVDDSRGSCFGPKFQTKPIYINIRERIIPDILGFLLHGKISCFVAGRVPTLQDAHISCSLPNTSEWSFDDYGWLISFLKYSRLVSKIQSRLFNTTSMLQSCTVCRTTVEALQAELEKWRDSIPRRFRPAEPLRPRMLGEPRALSIAIQIPLLLPIRVLLRPAQTLPNNPTLHLRPRWTGDFRRLRCLPSLANTNTNETVHSQAASVMVAMPTALARIKTPSSHPLTGRCTICLSGGRLEGIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>C8VQU1</accession>
    <name>C8VQU1_EMENI</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ANIA_11282</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF88780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050469131.1">
        <property type="nucleotide sequence ID" value="XM_050613304.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VQU1"/>
    <dbReference type="GeneID" id="74896891"/>
    <dbReference type="KEGG" id="ani:ANIA_11282"/>
    <dbReference type="HOGENOM" id="CLU_2812334_0_0_1"/>
    <dbReference type="InParanoid" id="C8VQU1"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF88780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="67" mass="7169" checksum="79AD69482D2AFFCE" modified="2009-11-03" version="1">MAGGAGLHAYIFGSDRLLSIDAALTRGLTYGVAYHLSPYPVTEPDDQWSPTSSFVMPRGIKLCVPEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>C8VRG1</accession>
    <name>C8VRG1_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_10005</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF90356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050469362.1">
        <property type="nucleotide sequence ID" value="XM_050611098.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VRG1"/>
    <dbReference type="GeneID" id="74896148"/>
    <dbReference type="KEGG" id="ani:ANIA_10005"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN10005"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_0_1"/>
    <dbReference type="InParanoid" id="C8VRG1"/>
    <dbReference type="OMA" id="GNAWDCA"/>
    <dbReference type="OrthoDB" id="1393670at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:001190">
        <property type="entry name" value="Short-chain dehydrogenase/reductase SDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF122">
        <property type="entry name" value="NAD(P)-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF90356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="289" mass="29842" checksum="AEEC0434A0AB803A" modified="2009-11-03" version="1">MSAIPTTPPSRSLAGKCAIVTGAGCAGDGIGNGRAIAIFLASDGCNVLCVDKNLEWAEKTVSIIQEHSRSSSQYGQAVSFQADVTCETDCSSIISQAISTFKRVDILINNVGIAGAPGTAVTVDMESWSKSLEVNVNSMVLMAKHAIPAMQKNSGEIKGSIVNMGSVAGLKGGTPHLLYPTSKGAVVNMTRAMAAHHAEDGIRVNCVCPGMLYTPMMYASGNGMSEEAREARRRRSLLGTEGNGWDCATAVVFLAGPHARWITGAILPVDAGTTAAVGIGMPKGASVNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C8VU23</accession>
    <name>C8VU23_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Origin recognition complex subunit Orc5, putative (AFU_orthologue AFUA_1G02500)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ANIA_10072</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ORC5 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF89731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050469258.1">
        <property type="nucleotide sequence ID" value="XM_050610982.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VU23"/>
    <dbReference type="STRING" id="227321.C8VU23"/>
    <dbReference type="GeneID" id="74896189"/>
    <dbReference type="KEGG" id="ani:ANIA_10072"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN10072"/>
    <dbReference type="eggNOG" id="KOG2543">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028223_2_0_1"/>
    <dbReference type="InParanoid" id="C8VU23"/>
    <dbReference type="OMA" id="QLRRWHG"/>
    <dbReference type="OrthoDB" id="365981at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002614">
        <property type="entry name" value="Origin recognition complex subunit Orc5, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020796">
        <property type="entry name" value="ORC5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047088">
        <property type="entry name" value="ORC5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048866">
        <property type="entry name" value="ORC5_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12705">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12705:SF0">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14630">
        <property type="entry name" value="ORC5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21639">
        <property type="entry name" value="ORC5_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orc1-like AAA ATPase" evidence="8">
        <location>
            <begin position="13"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="ORC5 lid" evidence="10">
        <location>
            <begin position="216"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="Origin recognition complex subunit 5 C-terminal" evidence="9">
        <location>
            <begin position="324"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="375"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="389"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF14630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CBF89731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="544" mass="58005" checksum="D7193A0DD8928822" modified="2009-11-03" version="1">MLPIEVSKSLSPQWPCREVQSRQLASLLAPGLSSPSTVVIHGISATCKSTIVTNVLALLEVPHAIVRSPECITGRHLLTKILWAVLNAVDRKDEWERFGKGRCEHVSSLAVLLGECLASHPGGALEKFVLVLDGIDKQREAPPTLLSALARLGEVIPSLTVILIVSSTPRPLFLQATGVPHINFPPYTREQATTIILSAGAPAVPGLPAETSLQLYPYFVSAVYDSLVGPTASSIPVFKSICEKLWPQFVAPITSGETPPGGNDEWDFSRLLVKNRSLFRRQGEAALVHRIVTEDAPSTTQNGALAKPSSLLTSISAPSPLPSLPYFATLVLTSAYLASHTPQRLDTIFFSKFSSSSLSARNKRAHHRRRLKVLSQAQAAEDKEAQAPAKRRRGLGKRTKTRITKSILENAFATTSATTSAAGGGPGITGPSTILTARPFPLERLIAIYHAINPNPPANPLRLTAIADSVYSELATLRRLRLVVPAAGRASGSRLGLGSAGVNSGNTTADVGEKWCVNVSGDWIGEMAKGIGIEVGEWLAGGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-12-14" modified="2025-10-08" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>G5EAT6</accession>
    <accession>C8V240</accession>
    <name>G5EAT6_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Malic enzyme</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">ANIA_06168</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="7">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="7">Divalent metal cations. Prefers magnesium or manganese.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the malic enzymes family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF70049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_663772.1">
        <property type="nucleotide sequence ID" value="XM_658680.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G5EAT6"/>
    <dbReference type="STRING" id="227321.G5EAT6"/>
    <dbReference type="GeneID" id="2871143"/>
    <dbReference type="KEGG" id="ani:ANIA_06168"/>
    <dbReference type="eggNOG" id="KOG1257">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011405_5_2_1"/>
    <dbReference type="InParanoid" id="G5EAT6"/>
    <dbReference type="OMA" id="ANYDTAN"/>
    <dbReference type="OrthoDB" id="5365701at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004471">
        <property type="term" value="F:malate dehydrogenase (decarboxylating) (NAD+) activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd05312">
        <property type="entry name" value="NAD_bind_1_malic_enz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10380:FF:000007">
        <property type="entry name" value="Malic enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000182">
        <property type="entry name" value="NAD-dependent malic enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10380">
        <property type="entry name" value="Malic enzyme, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015884">
        <property type="entry name" value="Malic_enzyme_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012301">
        <property type="entry name" value="Malic_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037062">
        <property type="entry name" value="Malic_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012302">
        <property type="entry name" value="Malic_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001891">
        <property type="entry name" value="Malic_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010052">
        <property type="entry name" value="PRK13529.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23406">
        <property type="entry name" value="MALIC ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23406:SF32">
        <property type="entry name" value="NADP-DEPENDENT MALIC ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00390">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03949">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000106">
        <property type="entry name" value="ME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00072">
        <property type="entry name" value="MALOXRDTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01274">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00919">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00331">
        <property type="entry name" value="MALIC_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Malic enzyme N-terminal" evidence="11">
        <location>
            <begin position="137"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="Malic enzyme NAD-binding" evidence="10">
        <location>
            <begin position="325"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="56"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="56"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="160"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="231"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="324"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="467"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="516"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CBF70049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="648" mass="71807" checksum="88C3C6EBA59F47F9" modified="2011-12-14" version="1">MRWIPSPGGSMLVSRGLLHKIRPSPSAQLPLSVFPSSSFVFGSRCHSGAAVTQKSRMARFPSQQSRPVHATPHVNHNGPIEQNYDTANPAYIRKYLRTYGLTPPRPESYETQKTRCLAQLALKQTPIDKFLYLSTLRKNNVHLFYRLVTDHLRELTPLIYTPVVGEACQRWSEIYQQPEGMYLSWEDRGNLASVIANWPQPNVEITCITDGSRILGLGDLGINGMGIPIGKLALYTTCAGIRPEATLPLTLDLGTSNKALREDPLYLGSRRDKITPDEEREFLDELMAALTERWPGIVIQFEDFKNPFPALERYQDVYTCFNDDIQGTGAVILGGVINAVKRSGVPCKDQRAVFFGAGSAGVGVAKQIVAFFMREGMTEDEARSCFWLVDTKGLVTADRGDKLAEHKVYFARTDNAGQQFKTLEEVVDHVKPSILMGLSTQGGVFTPEILRKMAEWNTNPMIFPLSNPSSKSECDFETAVTNTDGRVLFASGSPFPTMSFTNSAGETKMYYPGQGNNMYVFPGIGLGTILSKAVKVTDSMIYASGEALSKALTAEEIERGLLYPDLTRIRKVSVVVARNVIRAAQEAKVDRETTLRTMDDETLDAWIKSRMYDPHTEVQSLEREVGSILSTLGAPQQFVNGSSDEAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-12-14" modified="2026-01-28" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>G5EB90</accession>
    <accession>C8V9W1</accession>
    <name>G5EB90_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Plasma membrane ATPase</fullName>
            <ecNumber evidence="10">7.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">ANIA_04859</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The plasma membrane ATPase of plants and fungi is a hydrogen ion pump. The proton gradient it generates drives the active transport of nutrients by H(+)-symport. The resulting external acidification and/or internal alkinization may mediate growth responses.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O + H(+)(in) = ADP + phosphate + 2 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:20852"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIA subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.1" evidence="10"/>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF76607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_662463.1">
        <property type="nucleotide sequence ID" value="XM_657371.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G5EB90"/>
    <dbReference type="STRING" id="227321.G5EB90"/>
    <dbReference type="GeneID" id="2872657"/>
    <dbReference type="KEGG" id="ani:ANIA_04859"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN4859"/>
    <dbReference type="eggNOG" id="KOG0205">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002360_6_0_1"/>
    <dbReference type="InParanoid" id="G5EB90"/>
    <dbReference type="OMA" id="ILNMSEC"/>
    <dbReference type="OrthoDB" id="116380at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008553">
        <property type="term" value="F:P-type proton-exporting transporter activity"/>
        <property type="evidence" value="ECO:0000247"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120029">
        <property type="term" value="P:proton export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0000247"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051453">
        <property type="term" value="P:regulation of intracellular pH"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd02076">
        <property type="entry name" value="P-type_ATPase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000005">
        <property type="entry name" value="Plasma membrane ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000008">
        <property type="entry name" value="Plasma membrane ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006534">
        <property type="entry name" value="P-type_ATPase_IIIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01647">
        <property type="entry name" value="ATPase-IIIA_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="119"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="338"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="379"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="737"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="764"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="800"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="838"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="866"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="915"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="12">
        <location>
            <begin position="78"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CBF76607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="990" mass="108755" checksum="FFCD28DE12DD533D" modified="2011-12-14" version="1">MAERKISYAADVENGDHSRPTDVNDSAGLDEYGALNRYISTARDNRRGSTSSAGALSMKQKKKPWYKFWAKAGGENGEEGFVAPEDWLETDLNGLPSSQIEPRRKRGGWNELTTEKTNFFVQFIGYFRGPILYVMELAVLLAAGLRDWIDLGVIIGILMLNAVVGWYQEKQAADVVASLKGDIAMKAVVKRDGQEQEILARELVTGDIVVIEEGTIVPADVRLICDYDKPETYETYKEYLATANDDTLKENDDDDDDHGIEARLGVSLVAVDQSAITGESLAVDKYMADTCYYTTGCKRGKAYAIVTATAKHSFVGKTAALVQGAQDQGHFKAVMDNIGTSLLVLVMFWILAAWIGGFYRHLKIATPEHSDNTLLHWTLILLIIGVPVGLPVVTTTTLAVGAAYLAEQKAIVQKLTAIESLAGVDILCSDKTGTLTANQLSIREPYVNEGVDVNWMMAVAAIASNHNVKNLDPIDKVTILTLRRYPKAREILARNWVTEKYTPFDPVSKRITTICTCDGVRYTCAKGAPKAILAMSECSPEEAQKFREKASEFARRGFRSLGVAVQKEGEPWQLLGMYPMFDPPREDTAHTIAEAQHLGLSVKMLTGDALAIAKETCKMLALSTKVYDSERLIHGGLAGSAQHDLVEKADGFAEVFPEHKYQVVEMLQQRGHLTAMTGDGVNDAPSLKKADCGIAVEGSTEAAQAAADIVFLAPGLSTIVDAIKLARQIFQRMKAYIQYRIALCIHLELYLVTSMIIINETIKADLIVFIALFADLATIAVAYDNAHFEARPVEWQLPKIWVISVVLGVLLAAGTWIMRASLFLENGGIIQNFGSPQPMLFLEVSLTENWLIFVTRGGKTWPSWQLVGAIFVVDVLATLFCVFGWLAGDYVETSPPSQATFSTNNDTDIVTVVVIWAYSIGVTIIIAVVYYLLTIIPALDNLGRKNRSVVDTKVENLLNHLSKLAIEHEVDANGKSRYTLGARAEPEDDE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-06-13" modified="2026-01-28" version="110" xmlns="https://uniprot.org/uniprot">
    <accession>O74689</accession>
    <accession>C8V2D2</accession>
    <accession>Q5B005</accession>
    <name>NDE1_EMENI</name>
    <protein>
        <recommendedName>
            <fullName>Nuclear distribution protein nudE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">nudE</name>
        <name type="ORF">AN6125</name>
    </gene>
    <organism>
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="J. Cell Biol." volume="150" first="681" last="688">
            <title>The LIS1-related NUDF protein of Aspergillus nidulans interacts with the coiled-coil domain of the NUDE/RO11 protein.</title>
            <authorList>
                <person name="Efimov V.P."/>
                <person name="Morris N.R."/>
            </authorList>
            <dbReference type="PubMed" id="10931877"/>
            <dbReference type="DOI" id="10.1083/jcb.150.3.681"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA]</scope>
        <scope>INTERACTION WITH NUDF</scope>
        <source>
            <strain>XX20</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
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            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
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        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
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    </reference>
    <reference key="4">
        <citation type="journal article" date="2003" name="Mol. Biol. Cell" volume="14" first="871" last="888">
            <title>Roles of NUDE and NUDF proteins of Aspergillus nidulans: insights from intracellular localization and overexpression effects.</title>
            <authorList>
                <person name="Efimov V.P."/>
            </authorList>
            <dbReference type="PubMed" id="12631710"/>
            <dbReference type="DOI" id="10.1091/mbc.E02-06-0359"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2006" name="Mol. Biol. Cell" volume="17" first="2021" last="2034">
            <title>CLIP-170 homologue and NUDE play overlapping roles in NUDF localization in Aspergillus nidulans.</title>
            <authorList>
                <person name="Efimov V.P."/>
                <person name="Zhang J."/>
                <person name="Xiang X."/>
            </authorList>
            <dbReference type="PubMed" id="16467375"/>
            <dbReference type="DOI" id="10.1091/mbc.E05-11-1084"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5 6">Required for nuclear migration within hyphae during vegetative growth.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1 4">Self-associates (By similarity). Interacts with nudF.</text>
    </comment>
    <comment type="interaction">
        <interactant intactId="EBI-1009303">
            <id>O74689</id>
        </interactant>
        <interactant intactId="EBI-1009311">
            <id>Q00664</id>
            <label>nudF</label>
        </interactant>
        <organismsDiffer>false</organismsDiffer>
        <experiments>3</experiments>
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    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5 6">Cytoplasm</location>
            <location evidence="5 6">Cytoskeleton</location>
        </subcellularLocation>
        <text>Localizes to the plus ends of microtubules.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the nudE family.</text>
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    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
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    <keyword id="KW-0493">Microtubule</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0813">Transport</keyword>
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    <feature type="region of interest" description="Localization to microtubule plus ends">
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    <feature type="compositionally biased region" description="Low complexity" evidence="3">
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            <begin position="9"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="3">
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            <begin position="221"/>
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    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="10931877"/>
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            <dbReference type="PubMed" id="12631710"/>
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        <source>
            <dbReference type="PubMed" id="16467375"/>
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    </evidence>
    <evidence type="ECO:0000305" key="7"/>
    <sequence length="586" mass="64640" checksum="967BF91F066D1389" modified="1998-11-01" version="1">MPSADEPSSTRTNGTSSRSDQLAYYKKQYEQLESELADFQASSRELEAELEKEIEASEKRERQLKEKVDNLRYEVEEWKSKYKQSKSEASTAQNALQKEITSLRDANLTLQLKLRDTEVANDDYERQARHTTSSLEDMESKYNQALEREVLLDMEYKQGEQERESLRIENQRLRDELNDLKIETEIVQERLRNNNRRRRPAPLGRSPSTPHTPEIFDRSPGESTVSSPLFSTPPTKLSLTLASATATPPSPPMSETSSSMRKSLTAASGFPLQKASASESFGTRSLYGNRPQRFQAHSRATSYAFSNGRSTPSATTTRPSLPKANNTTANRPSGIPKSGSLHQIRGLIGKMQKLEERVQSAKSKLPPPSETASRASSRAGSMLDASPGAATIAMRRDTRKRLSGSSFSSSVRDGDGAPSYVTSSRPSYGTRTQGDSRPSSRTSFSSSLSHSTHPSVTPSNRPESRQSRTKTPLGHYSTNPTTESRRPRSSLSNPAGQSTPINGMTYIDEDEDLAEQFNMRATISSTRPTRLPSFSNPAFSTPTGLKKRSTSGMSGIPAPRTLRRGNTMGPPKTKPKPVAGDLGETF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1988-11-01" modified="2025-04-09" version="175" xmlns="https://uniprot.org/uniprot">
    <accession>P05326</accession>
    <accession>C8VHS7</accession>
    <accession>Q5BA08</accession>
    <name>IPNA_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Isopenicillin N synthase</fullName>
            <shortName evidence="10">IPNS</shortName>
            <ecNumber evidence="7">1.21.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ipnA</name>
        <name type="synonym">ips</name>
        <name type="ORF">AN2622</name>
    </gene>
    <organism>
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1987" name="Gene" volume="57" first="171" last="181">
            <title>Cloning and characterization of the isopenicillin N synthetase gene mediating the formation of the beta-lactam ring in Aspergillus nidulans.</title>
            <authorList>
                <person name="Ramon D."/>
                <person name="Carramolino L."/>
                <person name="Patino C."/>
                <person name="Sanchez F."/>
                <person name="Penalva M.A."/>
            </authorList>
            <dbReference type="PubMed" id="3319778"/>
            <dbReference type="DOI" id="10.1016/0378-1119(87)90120-X"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>PATHWAY</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1988" name="J. Bacteriol." volume="170" first="3817" last="3826">
            <title>Cloning and expression in Escherichia coli of isopenicillin N synthetase genes from Streptomyces lipmanii and Aspergillus nidulans.</title>
            <authorList>
                <person name="Weigel B.J."/>
                <person name="Burgett S.G."/>
                <person name="Chen V.J."/>
                <person name="Skatrud P.L."/>
                <person name="Frolik C.A."/>
                <person name="Queener S.W."/>
                <person name="Ingolia T.D."/>
            </authorList>
            <dbReference type="PubMed" id="3045077"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="5">
        <citation type="journal article" date="1995" name="Protein Sci." volume="4" first="1007" last="1009">
            <title>Crystallization and preliminary X-ray diffraction studies on recombinant isopenicillin N synthase from Aspergillus nidulans.</title>
            <authorList>
                <person name="Roach P.L."/>
                <person name="Schofield C.J."/>
                <person name="Baldwin J.E."/>
                <person name="Clifton I.J."/>
                <person name="Hajdu J."/>
            </authorList>
            <dbReference type="PubMed" id="7663335"/>
        </citation>
        <scope>CRYSTALLIZATION</scope>
    </reference>
    <reference evidence="17" key="6">
        <citation type="journal article" date="1995" name="Nature" volume="375" first="700" last="704">
            <title>Crystal structure of isopenicillin N synthase is the first from a new structural family of enzymes.</title>
            <authorList>
                <person name="Roach P.L."/>
                <person name="Clifton I.J."/>
                <person name="Fueloep V."/>
                <person name="Harlos K."/>
                <person name="Barton G.J."/>
                <person name="Hajdu J."/>
                <person name="Andersson I."/>
                <person name="Schofield C.J."/>
                <person name="Baldwin J.E."/>
            </authorList>
            <dbReference type="PubMed" id="7791906"/>
            <dbReference type="DOI" id="10.1038/375700a0"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) IN COMPLEX WITH IRON</scope>
        <scope>COFACTOR</scope>
    </reference>
    <reference evidence="12 13" key="7">
        <citation type="journal article" date="1997" name="Nature" volume="387" first="827" last="830">
            <title>Structure of isopenicillin N synthase complexed with substrate and the mechanism of penicillin formation.</title>
            <authorList>
                <person name="Roach P.L."/>
                <person name="Clifton I.J."/>
                <person name="Hensgens C.M."/>
                <person name="Shibata N."/>
                <person name="Schofield C.J."/>
                <person name="Hajdu J."/>
                <person name="Baldwin J.E."/>
            </authorList>
            <dbReference type="PubMed" id="9194566"/>
            <dbReference type="DOI" id="10.1038/42990"/>
        </citation>
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    </reference>
    <reference evidence="22 23 24" key="8">
        <citation type="journal article" date="1999" name="Nature" volume="401" first="721" last="724">
            <title>The reaction cycle of isopenicillin N synthase observed by X-ray diffraction.</title>
            <authorList>
                <person name="Burzlaff N.I."/>
                <person name="Rutledge P.J."/>
                <person name="Clifton I.J."/>
                <person name="Hensgens C.M.H."/>
                <person name="Pickford M."/>
                <person name="Adlington R.M."/>
                <person name="Roach P.L."/>
                <person name="Baldwin J.E."/>
            </authorList>
            <dbReference type="PubMed" id="10537113"/>
            <dbReference type="DOI" id="10.1038/44400"/>
        </citation>
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        <scope>COFACTOR</scope>
    </reference>
    <reference evidence="14 15 16" key="9">
        <citation type="journal article" date="2001" name="Chem. Biol." volume="8" first="1231" last="1237">
            <title>Alternative oxidation by isopenicillin N synthase observed by X-ray diffraction.</title>
            <authorList>
                <person name="Ogle J.M."/>
                <person name="Clifton I.J."/>
                <person name="Rutledge P.J."/>
                <person name="Elkins J.M."/>
                <person name="Burzlaff N.I."/>
                <person name="Adlington R.M."/>
                <person name="Roach P.L."/>
                <person name="Baldwin J.E."/>
            </authorList>
            <dbReference type="PubMed" id="11755401"/>
            <dbReference type="DOI" id="10.1016/S1074-5521(01)00090-4"/>
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    </reference>
    <reference evidence="20 21" key="10">
        <citation type="journal article" date="2003" name="Org. Biomol. Chem." volume="1" first="1455" last="1460">
            <title>Crystallographic studies on the reaction of isopenicillin N synthase with an unsaturated substrate analogue.</title>
            <authorList>
                <person name="Elkins J.M."/>
                <person name="Rutledge P.J."/>
                <person name="Burzlaff N.I."/>
                <person name="Clifton I.J."/>
                <person name="Adlington R.M."/>
                <person name="Roach P.L."/>
                <person name="Baldwin J.E."/>
            </authorList>
            <dbReference type="PubMed" id="12926272"/>
            <dbReference type="DOI" id="10.1039/b212270g"/>
        </citation>
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    </reference>
    <reference evidence="18 19" key="11">
        <citation type="journal article" date="2003" name="Biochem. J." volume="372" first="687" last="693">
            <title>Structural studies on the reaction of isopenicillin N synthase with the substrate analogue delta-(l-alpha-aminoadipoyl)-l-cysteinyl-d-alpha-aminobutyrate.</title>
            <authorList>
                <person name="Long A.J."/>
                <person name="Clifton I.J."/>
                <person name="Roach P.L."/>
                <person name="Baldwin J.E."/>
                <person name="Schofield C.J."/>
                <person name="Rutledge P.J."/>
            </authorList>
            <dbReference type="PubMed" id="12622704"/>
            <dbReference type="DOI" id="10.1042/bj20021627"/>
        </citation>
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    </reference>
    <reference evidence="25" key="12">
        <citation type="journal article" date="2004" name="Biochem. J." volume="382" first="659" last="666">
            <title>Active-site-mediated elimination of hydrogen fluoride from a fluorinated substrate analogue by isopenicillin N synthase.</title>
            <authorList>
                <person name="Grummitt A.R."/>
                <person name="Rutledge P.J."/>
                <person name="Clifton I.J."/>
                <person name="Baldwin J.E."/>
            </authorList>
            <dbReference type="PubMed" id="15175003"/>
            <dbReference type="DOI" id="10.1042/bj20040529"/>
        </citation>
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    </reference>
    <reference evidence="32" key="13">
        <citation type="journal article" date="2005" name="Biochem. Biophys. Res. Commun." volume="336" first="702" last="708">
            <title>Unique binding of a non-natural L,L,L-substrate by isopenicillin N synthase.</title>
            <authorList>
                <person name="Howard-Jones A.R."/>
                <person name="Rutledge P.J."/>
                <person name="Clifton I.J."/>
                <person name="Adlington R.M."/>
                <person name="Baldwin J.E."/>
            </authorList>
            <dbReference type="PubMed" id="16143309"/>
            <dbReference type="DOI" id="10.1016/j.bbrc.2005.08.155"/>
        </citation>
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    </reference>
    <reference evidence="26 27 28" key="14">
        <citation type="journal article" date="2005" name="Biochemistry" volume="44" first="6619" last="6628">
            <title>Structural studies on the reaction of isopenicillin N synthase with the truncated substrate analogues delta-(L-alpha-aminoadipoyl)-L-cysteinyl-glycine and delta-(L-alpha-aminoadipoyl)-L-cysteinyl-D-alanine.</title>
            <authorList>
                <person name="Long A.J."/>
                <person name="Clifton I.J."/>
                <person name="Roach P.L."/>
                <person name="Baldwin J.E."/>
                <person name="Rutledge P.J."/>
                <person name="Schofield C.J."/>
            </authorList>
            <dbReference type="PubMed" id="15850395"/>
            <dbReference type="DOI" id="10.1021/bi047478q"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.28 ANGSTROMS) IN COMPLEX WITH IRON AND SUBSTRATE ANALOG</scope>
    </reference>
    <reference evidence="29 30" key="15">
        <citation type="journal article" date="2006" name="ChemBioChem" volume="7" first="351" last="358">
            <title>Unexpected oxidation of a depsipeptide substrate analogue in crystalline isopenicillin N synthase.</title>
            <authorList>
                <person name="Daruzzaman A."/>
                <person name="Clifton I.J."/>
                <person name="Adlington R.M."/>
                <person name="Baldwin J.E."/>
                <person name="Rutledge P.J."/>
            </authorList>
            <dbReference type="PubMed" id="16444759"/>
            <dbReference type="DOI" id="10.1002/cbic.200500282"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.40 ANGSTROMS) IN COMPLEX WITH IRON AND SUBSTRATE ANALOG</scope>
    </reference>
    <reference evidence="33 34" key="16">
        <citation type="journal article" date="2007" name="Biochemistry" volume="46" first="4755" last="4762">
            <title>Interactions of isopenicillin N synthase with cyclopropyl-containing substrate analogues reveal new mechanistic insight.</title>
            <authorList>
                <person name="Howard-Jones A.R."/>
                <person name="Elkins J.M."/>
                <person name="Clifton I.J."/>
                <person name="Roach P.L."/>
                <person name="Adlington R.M."/>
                <person name="Baldwin J.E."/>
                <person name="Rutledge P.J."/>
            </authorList>
            <dbReference type="PubMed" id="17397141"/>
            <dbReference type="DOI" id="10.1021/bi062314q"/>
        </citation>
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    </reference>
    <reference evidence="35" key="17">
        <citation type="journal article" date="2007" name="ChemBioChem" volume="8" first="2003" last="2007">
            <title>A cyclobutanone analogue mimics penicillin in binding to isopenicillin N synthase.</title>
            <authorList>
                <person name="Stewart A.C."/>
                <person name="Clifton I.J."/>
                <person name="Adlington R.M."/>
                <person name="Baldwin J.E."/>
                <person name="Rutledge P.J."/>
            </authorList>
            <dbReference type="PubMed" id="17907118"/>
            <dbReference type="DOI" id="10.1002/cbic.200700176"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.30 ANGSTROMS) IN COMPLEX WITH IRON AND SUBSTRATE ANALOG</scope>
    </reference>
    <reference evidence="36 37" key="18">
        <citation type="journal article" date="2008" name="J. Am. Chem. Soc." volume="130" first="10096" last="10102">
            <title>Isopenicillin N synthase mediates thiolate oxidation to sulfenate in a depsipeptide substrate analogue: implications for oxygen binding and a link to nitrile hydratase?</title>
            <authorList>
                <person name="Ge W."/>
                <person name="Clifton I.J."/>
                <person name="Stok J.E."/>
                <person name="Adlington R.M."/>
                <person name="Baldwin J.E."/>
                <person name="Rutledge P.J."/>
            </authorList>
            <dbReference type="PubMed" id="18620394"/>
            <dbReference type="DOI" id="10.1021/ja8005397"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.40 ANGSTROMS) IN COMPLEX WITH IRON AND SUBSTRATE ANALOG</scope>
    </reference>
    <reference evidence="40 41" key="19">
        <citation type="journal article" date="2009" name="ChemBioChem" volume="10" first="2025" last="2031">
            <title>Structural studies on the reaction of isopenicillin N synthase with a sterically demanding depsipeptide substrate analogue.</title>
            <authorList>
                <person name="Ge W."/>
                <person name="Clifton I.J."/>
                <person name="Howard-Jones A.R."/>
                <person name="Stok J.E."/>
                <person name="Adlington R.M."/>
                <person name="Baldwin J.E."/>
                <person name="Rutledge P.J."/>
            </authorList>
            <dbReference type="PubMed" id="19598184"/>
            <dbReference type="DOI" id="10.1002/cbic.200900080"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.65 ANGSTROMS) IN COMPLEX WITH IRON AND SUBSTRATE ANALOG</scope>
    </reference>
    <reference evidence="39 42" key="20">
        <citation type="journal article" date="2010" name="Biochem. Biophys. Res. Commun." volume="398" first="659" last="664">
            <title>Crystallographic studies on the binding of selectively deuterated LLD- and LLL-substrate epimers by isopenicillin N synthase.</title>
            <authorList>
                <person name="Ge W."/>
                <person name="Clifton I.J."/>
                <person name="Stok J.E."/>
                <person name="Adlington R.M."/>
                <person name="Baldwin J.E."/>
                <person name="Rutledge P.J."/>
            </authorList>
            <dbReference type="PubMed" id="20603104"/>
            <dbReference type="DOI" id="10.1016/j.bbrc.2010.06.129"/>
        </citation>
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    </reference>
    <reference evidence="38" key="21">
        <citation type="journal article" date="2010" name="Org. Biomol. Chem." volume="8" first="122" last="127">
            <title>The crystal structure of an LLL-configured depsipeptide substrate analogue bound to isopenicillin N synthase.</title>
            <authorList>
                <person name="Ge W."/>
                <person name="Clifton I.J."/>
                <person name="Stok J.E."/>
                <person name="Adlington R.M."/>
                <person name="Baldwin J.E."/>
                <person name="Rutledge P.J."/>
            </authorList>
            <dbReference type="PubMed" id="20024142"/>
            <dbReference type="DOI" id="10.1039/b910170e"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) IN COMPLEX WITH IRON AND SUBSTRATE ANALOG</scope>
    </reference>
    <reference evidence="43" key="22">
        <citation type="journal article" date="2011" name="Arch. Biochem. Biophys." volume="516" first="103" last="107">
            <title>The crystal structure of isopenicillin N synthase with delta-((L)-alpha-aminoadipoyl)-(L)-cysteinyl-(D)-methionine reveals thioether coordination to iron.</title>
            <authorList>
                <person name="Clifton I.J."/>
                <person name="Ge W."/>
                <person name="Adlington R.M."/>
                <person name="Baldwin J.E."/>
                <person name="Rutledge P.J."/>
            </authorList>
            <dbReference type="PubMed" id="22001738"/>
            <dbReference type="DOI" id="10.1016/j.abb.2011.09.014"/>
        </citation>
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    </reference>
    <reference evidence="44" key="23">
        <citation type="journal article" date="2011" name="ChemBioChem" volume="12" first="1881" last="1885">
            <title>Isopenicillin N synthase binds delta-(L-alpha-aminoadipoyl)-L-cysteinyl-D-thia-allo-isoleucine through both sulfur atoms.</title>
            <authorList>
                <person name="Clifton I.J."/>
                <person name="Ge W."/>
                <person name="Adlington R.M."/>
                <person name="Baldwin J.E."/>
                <person name="Rutledge P.J."/>
            </authorList>
            <dbReference type="PubMed" id="21678539"/>
            <dbReference type="DOI" id="10.1002/cbic.201100149"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.79 ANGSTROMS) IN COMPLEX WITH IRON AND SUBSTRATE ANALOG</scope>
    </reference>
    <reference evidence="48" key="24">
        <citation type="journal article" date="2013" name="Arch. Biochem. Biophys." volume="530" first="48" last="53">
            <title>The crystal structure of isopenicillin N synthase with a dipeptide substrate analogue.</title>
            <authorList>
                <person name="Daruzzaman A."/>
                <person name="Clifton I.J."/>
                <person name="Adlington R.M."/>
                <person name="Baldwin J.E."/>
                <person name="Rutledge P.J."/>
            </authorList>
            <dbReference type="PubMed" id="23262315"/>
            <dbReference type="DOI" id="10.1016/j.abb.2012.12.012"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.40 ANGSTROMS) IN COMPLEX WITH IRON AND SUBSTRATE ANALOG</scope>
    </reference>
    <reference evidence="45 46" key="25">
        <citation type="journal article" date="2013" name="ChemBioChem" volume="14" first="599" last="606">
            <title>The interaction of isopenicillin N synthase with homologated substrate analogues delta-(L-alpha-aminoadipoyl)-L-homocysteinyl-D-Xaa characterised by protein crystallography.</title>
            <authorList>
                <person name="Daruzzaman A."/>
                <person name="Clifton I.J."/>
                <person name="Adlington R.M."/>
                <person name="Baldwin J.E."/>
                <person name="Rutledge P.J."/>
            </authorList>
            <dbReference type="PubMed" id="23468426"/>
            <dbReference type="DOI" id="10.1002/cbic.201200728"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.40 ANGSTROMS) IN COMPLEX WITH IRON AND SUBSTRATE ANALOGS</scope>
    </reference>
    <reference evidence="47" key="26">
        <citation type="journal article" date="2013" name="FEBS Lett." volume="587" first="2705" last="2709">
            <title>The crystal structure of an isopenicillin N synthase complex with an ethereal substrate analogue reveals water in the oxygen binding site.</title>
            <authorList>
                <person name="Clifton I.J."/>
                <person name="Ge W."/>
                <person name="Adlington R.M."/>
                <person name="Baldwin J.E."/>
                <person name="Rutledge P.J."/>
            </authorList>
            <dbReference type="PubMed" id="23860486"/>
            <dbReference type="DOI" id="10.1016/j.febslet.2013.07.016"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.82 ANGSTROMS) IN COMPLEX WITH IRON AND SUBSTRATE ANALOG</scope>
    </reference>
    <reference evidence="31" key="27">
        <citation type="journal article" date="2017" name="Chemistry" volume="23" first="12815" last="12824">
            <title>Terminally truncated isopenicillin N synthase generates a dithioester product: evidence for a thioaldehyde intermediate during catalysis and a new mode of reaction for non-Heme iron oxidases.</title>
            <authorList>
                <person name="McNeill L.A."/>
                <person name="Brown T.J.N."/>
                <person name="Sami M."/>
                <person name="Clifton I.J."/>
                <person name="Burzlaff N.I."/>
                <person name="Claridge T.D.W."/>
                <person name="Adlington R.M."/>
                <person name="Baldwin J.E."/>
                <person name="Rutledge P.J."/>
                <person name="Schofield C.J."/>
            </authorList>
            <dbReference type="PubMed" id="28703303"/>
            <dbReference type="DOI" id="10.1002/chem.201701592"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.30 ANGSTROMS) OF 1-325 IN COMPLEX WITH IRON AND N-[(5S)-5-AMINO-5-CARBOXYPENTANOYL]-L-CYSTEINYL-D-VALINE</scope>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>MUTAGENESIS OF LYS-98; LEU-223; LEU-231; VAL-272 AND PRO-283</scope>
    </reference>
    <reference evidence="49" key="28">
        <citation type="journal article" date="2020" name="IUCrJ" volume="7" first="901" last="912">
            <title>Anaerobic fixed-target serial crystallography.</title>
            <authorList>
                <person name="Rabe P."/>
                <person name="Beale J.H."/>
                <person name="Butryn A."/>
                <person name="Aller P."/>
                <person name="Dirr A."/>
                <person name="Lang P.A."/>
                <person name="Axford D.N."/>
                <person name="Carr S.B."/>
                <person name="Leissing T.M."/>
                <person name="McDonough M.A."/>
                <person name="Davy B."/>
                <person name="Ebrahim A."/>
                <person name="Orlans J."/>
                <person name="Storm S.L.S."/>
                <person name="Orville A.M."/>
                <person name="Schofield C.J."/>
                <person name="Owen R.L."/>
            </authorList>
            <dbReference type="PubMed" id="32939282"/>
            <dbReference type="DOI" id="10.1107/s2052252520010374"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.20 ANGSTROMS)</scope>
    </reference>
    <reference evidence="50" key="29">
        <citation type="submission" date="2020-06" db="PDB data bank">
            <title>Room temperature XFEL isopenicillin N synthase structure in complex with the Fe(IV)=O mimic VO and ACV.</title>
            <authorList>
                <person name="Rabe P."/>
                <person name="Kamps J.J.A.G."/>
                <person name="Sutherlin K."/>
                <person name="Pharm C."/>
                <person name="McDonough M.A."/>
                <person name="Leissing T.M."/>
                <person name="Aller P."/>
                <person name="Butryn A."/>
                <person name="Linyard J."/>
                <person name="Lang P."/>
                <person name="Brem J."/>
                <person name="Fuller F.D."/>
                <person name="Batyuk A."/>
                <person name="Hunter M.S."/>
                <person name="Pettinati I."/>
                <person name="Clifton I.J."/>
                <person name="Alonso-Mori R."/>
                <person name="Gul S."/>
                <person name="Young I."/>
                <person name="Kim I."/>
                <person name="Bhowmick A."/>
                <person name="O'Riordan L."/>
                <person name="Brewster A.S."/>
                <person name="Claridge T.D.W."/>
                <person name="Sauter N.K."/>
                <person name="Yachandra V."/>
                <person name="Yano J."/>
                <person name="Kern J.F."/>
                <person name="Orville A.M."/>
                <person name="Schofield C.J."/>
            </authorList>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.54 ANGSTROMS) IN COMPLEX WITH IRON AND SUBSTRATE ANALOG</scope>
    </reference>
    <reference key="30">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="0" last="0">
            <title>X-ray free-electron laser studies reveal correlated motion during isopenicillin N synthase catalysis.</title>
            <authorList>
                <person name="Rabe P."/>
                <person name="Kamps J.J.A.G."/>
                <person name="Sutherlin K.D."/>
                <person name="Linyard J.D.S."/>
                <person name="Aller P."/>
                <person name="Pham C.C."/>
                <person name="Makita H."/>
                <person name="Clifton I."/>
                <person name="McDonough M.A."/>
                <person name="Leissing T.M."/>
                <person name="Shutin D."/>
                <person name="Lang P.A."/>
                <person name="Butryn A."/>
                <person name="Brem J."/>
                <person name="Gul S."/>
                <person name="Fuller F.D."/>
                <person name="Kim I.S."/>
                <person name="Cheah M.H."/>
                <person name="Fransson T."/>
                <person name="Bhowmick A."/>
                <person name="Young I.D."/>
                <person name="O'Riordan L."/>
                <person name="Brewster A.S."/>
                <person name="Pettinati I."/>
                <person name="Doyle M."/>
                <person name="Joti Y."/>
                <person name="Owada S."/>
                <person name="Tono K."/>
                <person name="Batyuk A."/>
                <person name="Hunter M.S."/>
                <person name="Alonso-Mori R."/>
                <person name="Bergmann U."/>
                <person name="Owen R.L."/>
                <person name="Sauter N.K."/>
                <person name="Claridge T.D.W."/>
                <person name="Robinson C.V."/>
                <person name="Yachandra V.K."/>
                <person name="Yano J."/>
                <person name="Kern J.F."/>
                <person name="Orville A.M."/>
                <person name="Schofield C.J."/>
            </authorList>
            <dbReference type="PubMed" id="34417180"/>
            <dbReference type="DOI" id="10.1126/sciadv.abh0250"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.22 ANGSTROMS) IN COMPLEX WITH IRON AND SUBSTRATE ANALOG</scope>
    </reference>
    <comment type="function">
        <text evidence="2 5 6 7">Isopenicillin N synthase; part of the gene cluster that mediates the biosynthesis of penicillin, the world's most important antibiotic (PubMed:11755401, PubMed:3319778). IpnA catalyzes the cyclization of the tripeptide N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine (LLD-ACV or ACV) to form isopenicillin N (IPN) that contains the beta-lactam nucleus (PubMed:11755401, PubMed:28703303, PubMed:3319778). The penicillin biosynthesis occurs via 3 enzymatic steps, the first corresponding to the production of the tripeptide N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine (LLD-ACV or ACV) by the NRPS acvA. The tripeptide ACV is then cyclized to isopenicillin N (IPN) by the isopenicillin N synthase ipnA that forms the beta-lactam nucleus. Finally, the alpha-aminoadipyl side chain is exchanged for phenylacetic acid by the isopenicillin N acyltransferase penDE to yield penicillin in the peroxisomal matrix.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6 7">
            <text>N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + O2 = isopenicillin N + 2 H2O</text>
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        <cofactor evidence="3 4 8 9">
            <name>Fe(2+)</name>
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        </cofactor>
        <text evidence="3 4 8 9">Binds 1 Fe(2+) ion per subunit.</text>
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        <text evidence="7">Antibiotic biosynthesis; penicillin G biosynthesis; penicillin G from L-alpha-aminoadipate and L-cysteine and L-valine: step 2/3.</text>
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        <text evidence="1">Monomer.</text>
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            <location evidence="2">Cytoplasm</location>
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        <text evidence="11">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
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            <dbReference type="PDB" id="2IVJ"/>
        </source>
    </evidence>
    <evidence type="ECO:0007744" key="35">
        <source>
            <dbReference type="PDB" id="2JB4"/>
        </source>
    </evidence>
    <evidence type="ECO:0007744" key="36">
        <source>
            <dbReference type="PDB" id="2VAU"/>
        </source>
    </evidence>
    <evidence type="ECO:0007744" key="37">
        <source>
            <dbReference type="PDB" id="2VBB"/>
        </source>
    </evidence>
    <evidence type="ECO:0007744" key="38">
        <source>
            <dbReference type="PDB" id="2VBD"/>
        </source>
    </evidence>
    <evidence type="ECO:0007744" key="39">
        <source>
            <dbReference type="PDB" id="2VBP"/>
        </source>
    </evidence>
    <evidence type="ECO:0007744" key="40">
        <source>
            <dbReference type="PDB" id="2VCM"/>
        </source>
    </evidence>
    <evidence type="ECO:0007744" key="41">
        <source>
            <dbReference type="PDB" id="2VE1"/>
        </source>
    </evidence>
    <evidence type="ECO:0007744" key="42">
        <source>
            <dbReference type="PDB" id="2WO7"/>
        </source>
    </evidence>
    <evidence type="ECO:0007744" key="43">
        <source>
            <dbReference type="PDB" id="2Y60"/>
        </source>
    </evidence>
    <evidence type="ECO:0007744" key="44">
        <source>
            <dbReference type="PDB" id="2Y6F"/>
        </source>
    </evidence>
    <evidence type="ECO:0007744" key="45">
        <source>
            <dbReference type="PDB" id="3ZKU"/>
        </source>
    </evidence>
    <evidence type="ECO:0007744" key="46">
        <source>
            <dbReference type="PDB" id="3ZKY"/>
        </source>
    </evidence>
    <evidence type="ECO:0007744" key="47">
        <source>
            <dbReference type="PDB" id="3ZOI"/>
        </source>
    </evidence>
    <evidence type="ECO:0007744" key="48">
        <source>
            <dbReference type="PDB" id="4BB3"/>
        </source>
    </evidence>
    <evidence type="ECO:0007744" key="49">
        <source>
            <dbReference type="PDB" id="6Y0O"/>
        </source>
    </evidence>
    <evidence type="ECO:0007744" key="50">
        <source>
            <dbReference type="PDB" id="6ZAK"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="51">
        <source>
            <dbReference type="PDB" id="1ODM"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="52">
        <source>
            <dbReference type="PDB" id="6ZAQ"/>
        </source>
    </evidence>
    <sequence length="331" mass="37522" checksum="5BA1A726E9EEFA25" modified="1988-11-01" version="1">MGSVSKANVPKIDVSPLFGDDQAAKMRVAQQIDAASRDTGFFYAVNHGINVQRLSQKTKEFHMSITPEEKWDLAIRAYNKEHQDQVRAGYYLSIPGKKAVESFCYLNPNFTPDHPRIQAKTPTHEVNVWPDETKHPGFQDFAEQYYWDVFGLSSALLKGYALALGKEENFFARHFKPDDTLASVVLIRYPYLDPYPEAAIKTAADGTKLSFEWHEDVSLITVLYQSNVQNLQVETAAGYQDIEADDTGYLINCGSYMAHLTNNYYKAPIHRVKWVNAERQSLPFFVNLGYDSVIDPFDPREPNGKSDREPLSYGDYLQNGLVSLINKNGQT</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1992-12-01" modified="2026-01-28" version="144" xmlns="https://uniprot.org/uniprot">
    <accession>P28739</accession>
    <accession>C8V100</accession>
    <accession>Q5AZE0</accession>
    <name>KLPA_EMENI</name>
    <protein>
        <recommendedName>
            <fullName>Kinesin-like protein klpA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">klpA</name>
        <name type="ORF">AN6340</name>
    </gene>
    <organism>
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1993" name="J. Cell Biol." volume="120" first="153" last="162">
            <title>Suppression of the bimC4 mitotic spindle defect by deletion of klpA, a gene encoding a KAR3-related kinesin-like protein in Aspergillus nidulans.</title>
            <authorList>
                <person name="O'Connell M.J."/>
                <person name="Meluh P.B."/>
                <person name="Rose M.D."/>
                <person name="Morris N.R."/>
            </authorList>
            <dbReference type="PubMed" id="8416986"/>
            <dbReference type="DOI" id="10.1083/jcb.120.1.153"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA]</scope>
        <source>
            <strain>GB20</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
            <location evidence="4">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. NCD subfamily.</text>
    </comment>
    <comment type="sequence caution" evidence="4">
        <conflict type="erroneous gene model prediction">
            <sequence resource="EMBL-CDS" id="EAA58724" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EMBL" id="X64603">
        <property type="protein sequence ID" value="CAA45887.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AACD01000107">
        <property type="protein sequence ID" value="EAA58724.1"/>
        <property type="status" value="ALT_SEQ"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF69667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="A44337">
        <property type="entry name" value="A44337"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P28739"/>
    <dbReference type="SMR" id="P28739"/>
    <dbReference type="FunCoup" id="P28739">
        <property type="interactions" value="311"/>
    </dbReference>
    <dbReference type="STRING" id="227321.P28739"/>
    <dbReference type="EnsemblFungi" id="CBF69667">
        <property type="protein sequence ID" value="CBF69667"/>
        <property type="gene ID" value="ANIA_06340"/>
    </dbReference>
    <dbReference type="KEGG" id="ani:ANIA_06340"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN6340"/>
    <dbReference type="eggNOG" id="KOG0239">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001485_12_1_1"/>
    <dbReference type="InParanoid" id="P28739"/>
    <dbReference type="OMA" id="RHDMQKC"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000235">
        <property type="term" value="C:astral microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055028">
        <property type="term" value="C:cortical microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005871">
        <property type="term" value="C:kinesin complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0090619">
        <property type="term" value="C:meiotic spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036449">
        <property type="term" value="C:microtubule minus-end"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035371">
        <property type="term" value="C:microtubule plus-end"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005872">
        <property type="term" value="C:minus-end kinesin complex"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990537">
        <property type="term" value="C:mitotic spindle polar microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
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        <property type="project" value="GO_Central"/>
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    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
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        <property type="project" value="GO_Central"/>
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        <property type="term" value="F:minus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="AspGD"/>
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    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
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        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0030951">
        <property type="term" value="P:establishment or maintenance of microtubule cytoskeleton polarity"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000742">
        <property type="term" value="P:karyogamy involved in conjugation with cellular fusion"/>
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        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:1990571">
        <property type="term" value="P:meiotic centromere clustering"/>
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        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0140642">
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        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:1990810">
        <property type="term" value="P:microtubule anchoring at mitotic spindle pole body"/>
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        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0001578">
        <property type="term" value="P:microtubule bundle formation"/>
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        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031534">
        <property type="term" value="P:minus-end directed microtubule sliding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990942">
        <property type="term" value="P:mitotic metaphase chromosome recapture"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090307">
        <property type="term" value="P:mitotic spindle assembly"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140641">
        <property type="term" value="P:mitotic spindle formation (spindle phase two)"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051256">
        <property type="term" value="P:mitotic spindle midzone assembly"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090561">
        <property type="term" value="P:nuclear migration during mitotic telophase"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000743">
        <property type="term" value="P:nuclear migration involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031535">
        <property type="term" value="P:plus-end directed microtubule sliding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01366">
        <property type="entry name" value="KISc_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Kinesin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47972">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KLP-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47972:SF45">
        <property type="entry name" value="PROTEIN CLARET SEGREGATIONAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0206">Cytoskeleton</keyword>
    <keyword id="KW-0493">Microtubule</keyword>
    <keyword id="KW-0505">Motor protein</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000125384" description="Kinesin-like protein klpA">
        <location>
            <begin position="1"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="domain" description="Kinesin motor" evidence="2">
        <location>
            <begin position="421"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="175"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="106"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="514"/>
            <end position="521"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="770" mass="85801" checksum="EFD0F0FF39B5C7EB" modified="2011-10-19" version="3">MENVQSRMQGSRIPGLKEMNPSGTNARSRLPQPGAIANKPTAVPQLARTRSTTESTRIGAGPPSAARSVNGATKAHTRANSYANSSTLTRSASAASRPRGPLSSSTSGRPKTSMSTSRRPNGHALPRPATSLDTHQEERSYGGLGKRGEWDQDEREQNLESLFETFVSRISQQGQESSGLKDALEVYKSRVGELEEAKSEQTEQNIRLKVELDVSKSRLAEAEDALKNAQRDHEIAIDELMSRQRAECESVRYESQKSLDALKAQHESELKELRRQFERELEDEKCARVRELNQLHSKTALDAQLSQIELDKTIKELAATREDLQSLRTELDRERKNTNNLRQNLDTAASNSVTLESTISALKARIEFLESGREEQSEAFERLNQQMMDAMAETNAAKEKLRREETLRRKLHNQVQELKGNIRVFCRVRPTLENEGASDAAQFTYPDEGEDSKEINIIGPEEKSSFGTVTRKNHNFSFDHVFGPSAQNSDVFDEISQLVQSALDGYNVCIFCYGQTGSGKTHTMSSLDGMIPRAVHQIYETATSLEEKGWRYTMEGNFVEVYNENLNDLLGKAEELDKKKLEIRHDMQRGKTTITDATTVQLESPEMVESLLKRAAANRSVAATKANERSSRSHSIFILKLIGENYITGERSEGTLNLVDLAGSERLSHSGATGDRLKETQNINRSLSCLGDVIAALGQGKKDGHIPYRNSKLTYLLQFSLGGNSKTLMFVMVSPLQAHLSETLTSLKFATKVHNTHIGTAKKQTRVRDV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1997-11-01" modified="2025-06-18" version="104" xmlns="https://uniprot.org/uniprot">
    <accession>Q00746</accession>
    <accession>C8VPP3</accession>
    <accession>Q5BC98</accession>
    <name>ANG1_EMENI</name>
    <protein>
        <recommendedName>
            <fullName>Antigen 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>ASPND1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">aspnd1</name>
        <name type="ORF">AN1832</name>
    </gene>
    <organism>
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1997" name="Infect. Immun." volume="65" first="1335" last="1344">
            <title>Characterization of the Aspergillus nidulans aspnd1 gene demonstrates that the ASPND1 antigen, which it encodes, and several A.fumigatus immunodominant antigens belong to the same family.</title>
            <authorList>
                <person name="Calera J.A."/>
                <person name="Ovejero M.C."/>
                <person name="Lopez-Medrano R."/>
                <person name="Segurado M."/>
                <person name="Puente P."/>
                <person name="Leal F."/>
            </authorList>
            <dbReference type="PubMed" id="9119471"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>G1059</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the ZPS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="Z50175">
        <property type="protein sequence ID" value="CAA90537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AACD01000029">
        <property type="protein sequence ID" value="EAA64997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF85648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_659436.1">
        <property type="nucleotide sequence ID" value="XM_654344.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q00746"/>
    <dbReference type="FunCoup" id="Q00746">
        <property type="interactions" value="20"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q00746"/>
    <dbReference type="GlyCosmos" id="Q00746">
        <property type="glycosylation" value="4 sites, No reported glycans"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CBF85648">
        <property type="protein sequence ID" value="CBF85648"/>
        <property type="gene ID" value="ANIA_01832"/>
    </dbReference>
    <dbReference type="KEGG" id="ani:ANIA_01832"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN1832"/>
    <dbReference type="eggNOG" id="ENOG502RTN8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048223_0_0_1"/>
    <dbReference type="InParanoid" id="Q00746"/>
    <dbReference type="OMA" id="CNATQRR"/>
    <dbReference type="OrthoDB" id="4689212at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005178">
        <property type="term" value="F:integrin binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd11307">
        <property type="entry name" value="M35_Asp_f2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000043">
        <property type="entry name" value="Major allergen Asp F2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029482">
        <property type="entry name" value="HRXXH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039124">
        <property type="entry name" value="PRA1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39399">
        <property type="entry name" value="PROTEIN ZPS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39399:SF1">
        <property type="entry name" value="PROTEIN ZPS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13933">
        <property type="entry name" value="HRXXH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000041749" description="Antigen 1">
        <location>
            <begin position="17"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="230"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="233"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="264"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="1">
        <location>
            <position position="41"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="1">
        <location>
            <position position="71"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="1">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="1">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="277" mass="30595" checksum="187F7361BB159790" modified="1996-11-01" version="1" precursor="true">MQLLALTLALCASIAALPTQQTPLPLEDPIKSPFPIHHSCNATEQRQLATALQETVTLAEHAKDHILRWGNESAIYRKYFGDRPSLTAIGAYDIIVNGNPDNILFRCDNPDGNCALEGWGGHWRGENASDETVICELSYTTRRSLSTMCSQGYTISEWETNTFWAGDLLHRLYHMPAIGQGLVEHYADGYEGVLELAEGNRTEAVHDSETLQYFALEVYAYDVAVPGIGCVGGEEENDGQGEEQTEEPAQDDQQDEAAEEEIPENCHTHEGGELHCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AQL4</accession>
    <accession>C8V3S0</accession>
    <name>Q5AQL4_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Tc1-like transposase DDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_09416</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF74302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_868798.1">
        <property type="nucleotide sequence ID" value="XM_863705.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AQL4"/>
    <dbReference type="STRING" id="227321.Q5AQL4"/>
    <dbReference type="GeneID" id="3684008"/>
    <dbReference type="KEGG" id="ani:ANIA_09416"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN9416"/>
    <dbReference type="eggNOG" id="ENOG502S95U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033666_0_1_1"/>
    <dbReference type="InParanoid" id="Q5AQL4"/>
    <dbReference type="OMA" id="ILEQSHS"/>
    <dbReference type="OrthoDB" id="4349822at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tc1-like transposase DDE" evidence="2">
        <location>
            <begin position="110"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF74302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="283" mass="32709" checksum="7D7430A8263A20F4" modified="2005-04-26" version="1">MAIPRPSTPPEAPLEVTEISERSQSSRWLSRDDRICILTLRDAGFTYRQVQYTCQNEQSTPRKPPGQRPKLSEEDIDNIITFISSSQPTFIGRYKACFHTRIWVTRRAGEELDETCICLSTPKKHGWMFWGSFYGDTKGPCLFWEKEWGSINAESYCERIVPIIDGYLRLNRQQGNYLCLMHDGAPGHASKDTIAELHERSIYPISWPAFSPDLNPIEMVWNWMKDWMQERYPDDRQLSYDALQEIVRASWDAVPTDFLEGLIGSMQARCQAVIEAEGGHTKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AR18</accession>
    <accession>C8VQA3</accession>
    <name>Q5AR18_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ANIA_09262</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF87275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_682531.1">
        <property type="nucleotide sequence ID" value="XM_677439.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AR18"/>
    <dbReference type="GeneID" id="2867873"/>
    <dbReference type="KEGG" id="ani:ANIA_09262"/>
    <dbReference type="eggNOG" id="ENOG502SK6F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015641_1_0_1"/>
    <dbReference type="InParanoid" id="Q5AR18"/>
    <dbReference type="OMA" id="FNSCLHR"/>
    <dbReference type="OrthoDB" id="2426273at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39596">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39596:SF4">
        <property type="entry name" value="HET DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_3G03140)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF87275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="792" mass="90034" checksum="0448C71101566AA5" modified="2005-04-26" version="1">MHTSEEIKAAMEKWCRDAFAFVDPGSGHDLNSHLAQLDAHLSTLLVCNFQTYKQDMGEAAIVDNACALLGRLPSNPPELPYQYDGRKAQDAQEKDKQELWPAAYFVENSKETAEDPEESNNWGRRYDWASLQVLSRPNTNTIRLVLFKVMDRADPQGCPSGYSETLGSLLDIVTGLLGESSTEEEAKAWFVLQAFLWAAWQHTIMIHLWYDAKRQMYNYKFYNHNDIVAHQIPAVMPPREIIERSRPNYMCKWAFELLRSDLSCVTQDFRKFFEIYEEHFGGRGPRCNLLPPGHEANIAQPRRICDGKAPGNCERFESESVQIQGAHDFGCPGPGPDSPCHFLVWDEASYLNTRGARAVSIEDTDDTHIRYTPVTRDTMAVSHVWSHGQGGRPETGFNSCLHRRYVTLARFLGCTSYWMDTPCVPTDRTLRSECLGQINANFESSKVTLLVDRDIMEIDIHPRTLAAEEAILAALVVCDWNVRAWTLLEGMRGRVRLHLLCKNNHVISLADVLNDVLSNSCLSLVSLCLAVQHYIPIPEPPGGIDLDPVSIEQATCLLNHRHATKDRDVPMIWALVAGSPKVIKASEEFWLSKVGKFLNTGNLISSAPRIPGRRGIGWAPARPNLLPPNATTEEKRYPAYDGQNSVPGKITAEGFEAEWLAVILRRRGMGLPAWMFSIYRFPRESEWDEYYHVYNKGGSDRIDLKMRQRIGALIAPLFQRFRYVAFLLPLLRYKGTNGAVIPPQPFQYQGEAEGPVMVVVGSNNQKEWEWQFLYEWKEEQLPEFWQTQLLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="132" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ARB2</accession>
    <accession>C8VK24</accession>
    <name>Q5ARB2_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ANIA_09168</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF82403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_682437.1">
        <property type="nucleotide sequence ID" value="XM_677345.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ARB2"/>
    <dbReference type="FunCoup" id="Q5ARB2">
        <property type="interactions" value="15"/>
    </dbReference>
    <dbReference type="GeneID" id="2868048"/>
    <dbReference type="KEGG" id="ani:ANIA_09168"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_3_1"/>
    <dbReference type="InParanoid" id="Q5ARB2"/>
    <dbReference type="OMA" id="GKWEVGQ"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015793">
        <property type="term" value="P:glycerol transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000061">
        <property type="entry name" value="MFS sugar transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF55">
        <property type="entry name" value="SUGAR TRANSPORTER STL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="318"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="351"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="381"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="442"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="17"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBF82403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="543" mass="60056" checksum="CBDDC906138D60C2" modified="2005-04-26" version="1">MWTNTSGLRGKSLHLFITFTAVMGFSLFGYNQGMMSGIIAGTEFVGEFEALKMPTDYTDAEYRHINVLRGAVTACYEIGCFFGALVSMFYGERVGRTRVIISGATILIIGAVISCAGFGPHWGLGQFVVGRVVSGIGNGLNTATIPVWQSECSASHNRGLLVCFEGAMIAVGTLIAYWVVFGLSYVDQSVQWRFPVALQVLFALIVVTGAILLPDSPRWFIMRGYDSEAIEVLAKLKNDSPDSEAVLADYNFMKADVEMTKTSQAGFKVLFTFGKTQEFQRCMLGCAGQFFQQFTGCNAAIYYSTLLFEENLHLEHRLALTMGGVFATVYALATIPSFFMIEKVGRRKLFLIGFLGQGLSFIITMACLIKDNEENSKGAIVGIFLFIVFFAFTLLPLPWIYPPEINPLRTRTAGASASTCTNWITNFAVVMFTPLFAATSPWGVYLFFALINFIGVPVAYFFFVETAGRELEEIDIIYAKAHVEKRMPFRVANDMPKLSLAEINQQARELGLDTNSDSHHQVAELGLSSDNSSNEKQEQHEKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ARM6</accession>
    <accession>C8VKP4</accession>
    <name>Q5ARM6_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_09054</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF84383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_682323.1">
        <property type="nucleotide sequence ID" value="XM_677231.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ARM6"/>
    <dbReference type="GeneID" id="2868187"/>
    <dbReference type="KEGG" id="ani:ANIA_09054"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN9054"/>
    <dbReference type="eggNOG" id="ENOG502RYTS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072152_0_0_1"/>
    <dbReference type="InParanoid" id="Q5ARM6"/>
    <dbReference type="OMA" id="TIDTWIE"/>
    <dbReference type="OrthoDB" id="10010954at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010219494" evidence="1">
        <location>
            <begin position="18"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF84383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="290" mass="32650" checksum="47AF6F6E143A1069" modified="2005-04-26" version="1">MRSSIALVLAVGTAALADFTFDELWALQNTLWDNFLYPANLQQINATDTSVFAENVQGRVDITRTFDGRELNNEYIFGLFSDPSHLSLVGIPISYNITQFAANQNITSATTVFTFNATSFNILVPITIDTWILYNADGKILQYDATFRWFGWLLDTLLEAAGTGIFNTTDPAETQRALGNLLATTICQTHGQHCVDDNQQYNSNEDCVRFLTEDIRFGSAYELGRNTLLCREVHEHMVQYRPTEHCPHIGPDGGGYCVDDKDYAEVVTERYFREPFVPYGYGDTNLWVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="111" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ARU5</accession>
    <accession>C8VL17</accession>
    <name>Q5ARU5_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Aldehyde dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ANIA_08985</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF84515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_682254.1">
        <property type="nucleotide sequence ID" value="XM_677162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ARU5"/>
    <dbReference type="STRING" id="227321.Q5ARU5"/>
    <dbReference type="GeneID" id="2868249"/>
    <dbReference type="KEGG" id="ani:ANIA_08985"/>
    <dbReference type="eggNOG" id="KOG2456">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005391_3_1_1"/>
    <dbReference type="InParanoid" id="Q5ARU5"/>
    <dbReference type="OMA" id="PLVAYWF"/>
    <dbReference type="OrthoDB" id="440325at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006081">
        <property type="term" value="P:aldehyde metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016117">
        <property type="term" value="P:carotenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07135">
        <property type="entry name" value="ALDH_F14-YMR110C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000004">
        <property type="entry name" value="Aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012394">
        <property type="entry name" value="Aldehyde_DH_NAD(P)"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43570">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43570:SF16">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE TYPE III, ISOFORM Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036492">
        <property type="entry name" value="ALDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0125">Carotenoid biosynthesis</keyword>
    <keyword evidence="3 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="6">
        <location>
            <begin position="6"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="216"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR036492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR036492-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBF84515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="530" mass="58603" checksum="A5403354E5064212" modified="2005-04-26" version="1">MAEYTSDADVELAYTTLQTTFKSGKTKEIAWRKWQLKQIWWLVDDNEALIQEALKKDMNRHPFETTFTECANVKGDVIEHLKNIDKWTADQKPSAGMLGLMLRPTVRPEPLGVALIIGPWNFPFSLLVQPLIAAITAGCAALLKPSEVTSSVQQLFVDLVPKYLDTSAVRVVTGGPAETGCLLQRKFDHIFFTGSVPVARHIAAAAAKHLTPTVLELGGQCPAIVTSSADVDAAAKDIAWIKYLNAGQICLSVNHVFAHPSVERKLIERMAFWLDRFYKGEKDAMTHIVNDKNYARIKQLAEKTKGKIELDGTADAETRSLPVSIVSNVEMSDPLLSEELFGTVCPVIKGSTDDAIKSINSLPRPLALYIFSQDQNEVEHIISSTLSGGVCVNGVLVHAMVPNAPFGGVGDSGHGAYHGEYGFKSFTHYRTIARPAPFFFKMSEWMRPPYSVDNIKKLAVRNSVGIQRNWSLEQEREAIKRGLLLTKSLKSARFLVYLVVLLGLADVGLDRRLGVLKSVRDLLVEVRSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ASJ2</accession>
    <accession>C8VA05</accession>
    <name>Q5ASJ2_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ANIA_08738</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="230" mass="25157" checksum="CE8787A131477CC9" modified="2005-04-26" version="1">MLSEEDAHTYKVRRHPLVRAANTTEAMGSSLIKRLAHTLENQSAKTAVITSRLIGDLVILAPSFFSWCILAAQQSGITVADRPRNAWSIWVGIFTYQSAAWERRQWSMLGVNTVATAIRVDGFHAISNFISGQGLPRHSEHPDLASPKSSLDQLLDESIILALDVSPLICSKRQIATATVLKVCGGVGLIGAKFCELETVEPYGNDSDIASHLPMVGETKSYSNRFSQFT</sequence>
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    <accession>Q5AT53</accession>
    <accession>C8VEP3</accession>
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            <fullName evidence="3">ThiJ/PfpI family protein (AFU_orthologue AFUA_5G14240)</fullName>
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        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
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            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
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            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
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            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
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        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
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        <property type="protein sequence ID" value="CBF80731.1"/>
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        <property type="nucleotide sequence ID" value="XM_676704.1"/>
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    <dbReference type="eggNOG" id="ENOG502S46I">
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    <dbReference type="OMA" id="MEYEWHE"/>
    <dbReference type="OrthoDB" id="543156at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
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    <dbReference type="CDD" id="cd03139">
        <property type="entry name" value="GATase1_PfpI_2"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Class_I_gatase-like"/>
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        <property type="entry name" value="DJ-1/PfpI"/>
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        <property type="entry name" value="INH-QAR"/>
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    <dbReference type="PANTHER" id="PTHR43130">
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        <property type="entry name" value="THIJ_PFPI FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G14240)"/>
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        <location>
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        </location>
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    </feature>
    <feature type="domain" description="DJ-1/PfpI" evidence="2">
        <location>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CBF80731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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    <reference evidence="10" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
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            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
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                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
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            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="CAZy" id="GH55">
        <property type="family name" value="Glycoside Hydrolase Family 55"/>
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    <dbReference type="GeneID" id="2868613"/>
    <dbReference type="KEGG" id="ani:ANIA_08480"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN8480"/>
    <dbReference type="eggNOG" id="KOG2806">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_002540_4_1_1"/>
    <dbReference type="InParanoid" id="Q5ATA0"/>
    <dbReference type="OMA" id="VEIQDMM"/>
    <dbReference type="OrthoDB" id="1046782at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
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    <dbReference type="GO" id="GO:0005576">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23668">
        <property type="entry name" value="GH55_beta13glucanase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000049">
        <property type="entry name" value="Putative exo-beta-1,3-glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052210">
        <property type="entry name" value="LysM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024535">
        <property type="entry name" value="RHGA/B-epi-like_pectate_lyase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34997">
        <property type="entry name" value="AM15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34997:SF16">
        <property type="entry name" value="LYSM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12708">
        <property type="entry name" value="Pect-lyase_RHGA_epim"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010172053" description="LysM domain-containing protein" evidence="7">
        <location>
            <begin position="32"/>
            <end position="1380"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="8">
        <location>
            <begin position="1164"/>
            <end position="1210"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="8">
        <location>
            <begin position="1314"/>
            <end position="1362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="37"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="98"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="121"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="151"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBF80635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="1380" mass="152332" checksum="0E4517D4E9AF4BB7" modified="2005-04-26" version="1">MRPAKVSVSWFQVLSIFLVIAICLFISTARASHSHLHHRHHDRRHNKSELSQNQGDQDVPDDPETMVRNALAVLAHVNKERVEYPNFNLYTTREDDETKLASATATPLPYTSEAVRKAQLRRRDDSTDASKRGSQPYSIPPELAKAAKTVAESTDNIPNGNHSDVAAMIRNKYGRDKRYTNTPNQAIIHSNGLYDYQSNTKPTNISISTQDGARDNTLQQRAPSQYWMPHMKKNGLSPYATSDYKIWRNVRDYGAKGDGVTDDTEAINRAISDGGRCGENCGSSTRFPAVVWFPGGKYLVSSSIIQYYNTQFIGDPLNVPTILAASSFVGLGVITSDPYVGDNAQWYLNQNNFLRSIKNFKIDIRLTDPSAYVCGIHWQVAQGTSLENIEFYMLYNSDVPENTQQGIYMENGSGGFLADLTFFTTSQLVFVNCKTALQVHWDWAWTMQDYVIESCTSGLTIVGGAGGPLSTGQGVGSLILADAIIANTPNGIVTSLHAENSTSLLLHNVGFFNVKTAVIDNVMNKVLLAGGDEVLKDSWGFGTVTDASGVSTFVNGADIPVMSRTAIMTGTQAYVKPNWFTRRRPQYEDLATEDIVNVKLFGVKGDGVTDDTVMLNWVLSYAANLSSVVYFPYGVYAIKDTLKVPVGSRIVGQAWPQIMAMGLKFQDVDSPHVAVKVGDPGDTGVIEIQDMLFTTAGPTAGAVVVEWNVAQSTKGSTAMWDSHIRIGGAYGSRLRKQQCPKKTGSVNPNCIGASLLLHLTPTSTPYLENIWAWVADHDLDLKSQDQIDVYSARGILIESKQAWLYGTSSEHNVLYQYQLSGAENILLAMIQTESPYYQPVPLAPQPFTPGRFPNDPTFDDCTTNKLKCAMSWAARIIDSSNIYMLGSGFYSFFSDYSQTCLETNNCQRKGLEIEQSTNIWIHNLCTKAIVEMVSPFNGVPTYARDNVNGFLSSILAWLGGAEETAGRREFAGFTLYSTSSLDHLELPDSCKTALKERVKCHPYVKLMTKSGYHRSPGNATLTDSVCDPSCGRSLQQWHDSVARNCAGYKMSRGASPTMFGAYMWAGFNETCSKDETTGEYCNDIISRFTVVNSVEQMPQDEICSYCYVERHKMMQSTPYSAYDDFYKFRLETINKRCGLSAPTEIKEIPLDPLPVEESPCFSEKTYITSDGDTCTSIAQANNISSAALYMGNQRVIRWCSSIKTGLELCLPLSCQRIYDLQQDDSCSSIEFAFELERGDVRKFNPWVTPECDNLEVGREIYGTTICLSPQGGEHVADKQGTGTTPSTSDGHQWLMIPPPDNATVAENTTMNCGRWHEAVEGESCVAICLQNMITHALFVEVNPSLDSVGCTASLQVGKIYCTGPTYDWNTAVESNPNEVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AUC6</accession>
    <accession>C8V6L4</accession>
    <name>Q5AUC6_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RTA1 domain protein, putative (AFU_orthologue AFUA_3G01030)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ANIA_08104</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF73895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_681373.1">
        <property type="nucleotide sequence ID" value="XM_676281.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AUC6"/>
    <dbReference type="FunCoup" id="Q5AUC6">
        <property type="interactions" value="21"/>
    </dbReference>
    <dbReference type="GeneID" id="2869120"/>
    <dbReference type="KEGG" id="ani:ANIA_08104"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN8104"/>
    <dbReference type="eggNOG" id="ENOG502SH4C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033465_3_1_1"/>
    <dbReference type="InParanoid" id="Q5AUC6"/>
    <dbReference type="OMA" id="YVMANEW"/>
    <dbReference type="OrthoDB" id="3358017at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF27">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01030)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="241"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBF73895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="283" mass="31553" checksum="9296C2276E217C59" modified="2005-04-26" version="1">MAKLEPYVDDYYLWEYIPSLPASIIFVLLFLAATLFHCWKAWKSRARFCIPFCIGGIFEVIGFGTRAACTDNTGKLMPYTIQSVFILLGPVLYAASVYMVLARLIRSVGAEEYSLIRNTRVTKTFVTGDIVSFLVQGSGAGLMAMGGSMTNVAKGIVIAGLMVQIVIFGFFMVTSAVFDQRMRRYPTSLSMSRNGGDGIGWKEHLYPLYAVSILIMIRSIFRVIEYAMGQKGYLLAHEWPIYVFDAVLMLGVMVIWGRWHPGSIRTEGMGAQLFSMNSGQSKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AVU8</accession>
    <accession>C8VBS1</accession>
    <name>Q5AVU8_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_07582</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF79674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_680851.1">
        <property type="nucleotide sequence ID" value="XM_675759.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AVU8"/>
    <dbReference type="GeneID" id="2869533"/>
    <dbReference type="KEGG" id="ani:ANIA_07582"/>
    <dbReference type="HOGENOM" id="CLU_1845077_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AVU8"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF79674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="139" mass="15175" checksum="417EF1923E005227" modified="2005-04-26" version="1">MIVRREKEVQVSEQSLEGKLRATEAERSGGVGEEESSDAIIVRFVAAAPLPFCSKAGTRLNGISQTTCIPKQSISFDKCGIGNGRGLNPDKDQYLLSSYIGDFATSYKSYKVQRYTARVSATTVHKSYAQLNCATYAHV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-03-07" modified="2026-01-28" version="121" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AW75</accession>
    <accession>C8VBD1</accession>
    <name>JHD1_EMENI</name>
    <protein>
        <recommendedName>
            <fullName>JmjC domain-containing histone demethylation protein 1</fullName>
            <ecNumber evidence="2">1.14.11.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>[Histone-H3]-lysine-36 demethylase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">jhd1</name>
        <name type="ORF">AN7455</name>
    </gene>
    <organism>
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + 2 2-oxoglutarate + 2 O2 = L-lysyl(36)-[histone H3] + 2 formaldehyde + 2 succinate + 2 CO2</text>
            <dbReference type="Rhea" id="RHEA:42032"/>
            <dbReference type="Rhea" id="RHEA-COMP:9785"/>
            <dbReference type="Rhea" id="RHEA-COMP:9787"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:16842"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:61976"/>
            <dbReference type="EC" id="1.14.11.27"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="1">Binds 1 Fe(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">The JmjC domain mediates the demethylation activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the JHDM1 histone demethylase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.27" evidence="2"/>
    <dbReference type="EMBL" id="AACD01000129">
        <property type="protein sequence ID" value="EAA62035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF79416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_680724.1">
        <property type="nucleotide sequence ID" value="XM_675632.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AW75"/>
    <dbReference type="SMR" id="Q5AW75"/>
    <dbReference type="STRING" id="227321.Q5AW75"/>
    <dbReference type="EnsemblFungi" id="CBF79416">
        <property type="protein sequence ID" value="CBF79416"/>
        <property type="gene ID" value="ANIA_07455"/>
    </dbReference>
    <dbReference type="GeneID" id="2869726"/>
    <dbReference type="KEGG" id="ani:ANIA_07455"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN7455"/>
    <dbReference type="eggNOG" id="KOG1633">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002979_0_1_1"/>
    <dbReference type="InParanoid" id="Q5AW75"/>
    <dbReference type="OMA" id="KFGIWVA"/>
    <dbReference type="OrthoDB" id="5876800at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032452">
        <property type="term" value="F:histone demethylase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140680">
        <property type="term" value="F:histone H3K36me/H3K36me2 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15517">
        <property type="entry name" value="PHD_TCF19_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041070">
        <property type="entry name" value="JHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050690">
        <property type="entry name" value="JHDM1_Histone_Demethylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23123">
        <property type="entry name" value="PHD/F-BOX CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17811">
        <property type="entry name" value="JHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02373">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
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    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0156">Chromatin regulator</keyword>
    <keyword id="KW-0223">Dioxygenase</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <keyword id="KW-0863">Zinc-finger</keyword>
    <feature type="chain" id="PRO_0000226797" description="JmjC domain-containing histone demethylation protein 1">
        <location>
            <begin position="1"/>
            <end position="1407"/>
        </location>
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            <begin position="577"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="PHD-type" evidence="3">
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            <begin position="323"/>
            <end position="382"/>
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        <location>
            <begin position="1"/>
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    </feature>
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            <end position="987"/>
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            <begin position="1252"/>
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            <begin position="125"/>
            <end position="140"/>
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            <begin position="141"/>
            <end position="150"/>
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            <end position="914"/>
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            <begin position="1008"/>
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            <begin position="1273"/>
            <end position="1284"/>
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            <begin position="1285"/>
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            <position position="628"/>
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        <ligand>
            <name>substrate</name>
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    <feature type="binding site" evidence="4">
        <location>
            <position position="631"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
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    <feature type="binding site" evidence="4">
        <location>
            <position position="633"/>
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        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
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            <position position="648"/>
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        <ligand>
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        <location>
            <position position="703"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="P40034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00538"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000305" key="6"/>
    <sequence length="1407" mass="156107" checksum="CE85B1C78A76A2D0" modified="2005-04-26" version="1">MISATSFVTAIGSRPPRYRTPSPPRRAVEPISPCSTADYRTYRASREISASATSDHVRSTPTDKRPSPADVPASHRSGHGRSSSTIDTLATIALATSPTFTPLTHRPPSDKSNTTLSMFPPETEPVERPAKRPRSERDESSYTQHRSNAFSIARPPAISDSMKTDAELLLNFARPTNLYPPIPSSKRANTDDSYHNHTFHTQAQIKERNASTYWVTNHENVIFNHSAMHNIPPSRMRSQSDGSAAISRPVIEGLRPNTSSSTLPPLAFQEEADSGDRHWDMERKPVLEESQVDFCKPDETVPILSQSQPLKKELDADSNGSSQASCATCNLVRIPVDNEDQDVTWISCDGCKRWFHIVCAGFKNDRETRTVDKFICKTCRPIHGQTTFVRKSSRVRTSIDYAGLNQGLVKSATDSLEHHYIEPIKQNKIRFLPENFPRMRPELVTAEYFEKGNGMTEPIVIPAEFNTHATIPPTNPEFDALVQDAPSQEMFDELLDHLPNVDHETVIDCGQNQLDMVIPQGLTVRTVSELYGPEERVEVIDVKSQHGEDKRWTMQKWADYYESTGDKVVRNVISLEVSQSKLGRLIRRPKIVRDLDLQDAVWPEELKAVGNFPKVQFYCLMSVADCYTDFHIDFGGSSVYYHILKGKKTFFFIPPKDKHLKKYEEWCNSPAQDYTFLGDQTKECYRVDLSEGDTMLIPSGWIHAVWTPENSLVIGGNFLTRLNYGMQIKIAKIEKETKVPMKFRYPFFQKIQWYAVLKYLEEDPVPQSVLAAFSQDENYRFHRKYPIYYEFGERANTEPKGSPYHNSRFYSQAELEGLPDLAKYLLRTALIAGSYLVEGVTADTRNAVKRSIPAMPGEPIDVIRTFGVWIAWKRGNEKAAHWTRPGVVESNAKLSLAEKRPAGRPSRRSERNADNQRTYAERQAVQRLSERPAVDIQKDSAPGDESVAPLANNSPPAATSGIPVPVMNEDTSQKHKTASRGSGLGPKRVACDACRKRRIRCHHKEENNGASGSQMTVSTSSLGHHTPTAQDAASALNSLAAIASGAGFQNGLHSIKGMDRMDASANFATSISATPHGVTLKVGDGSPDGLNSAKKGRSKACDDCRKSKRRCIHDEYGRIDPIKAQERSKPRATSLAKRPRVHEEAAPSSANKRLKQESTSPVAQPVHSSHMDTETPTRAQDSVENGVLDQYPRKSNTQHADGLPAEKALLPDQSSYASPPAFQADAVATKELPATVSKPAAVLVSPPTSLADEMDIHDQVDAGGEHVSVIYTPSSGSRQSSRQPRQVERYMPEVHFAKTAKSTTTTPQTTRRSSFGSSGRKTTPGLSSGSKKSGSRPSSSHGKKSLSPSVEKKAERHAISSAPFGQHGRGSKSEHGTSDVDPDAESLRLIREIQEQEFGLRRRAGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AW86</accession>
    <accession>C8VBB8</accession>
    <name>Q5AW86_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GTPase activating protein (Gyp1), putative (AFU_orthologue AFUA_2G06080)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_07444</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_675621.1"/>
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        <property type="component" value="Chromosome IV"/>
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        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TBC1 domain family member"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TBC1 domain family member 22A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
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        <property type="entry name" value="Rab-GAP-TBC_dom"/>
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        <property type="entry name" value="Rab-GAP_TBC_sf"/>
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        <property type="entry name" value="LD44506P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="272"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="66"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF79393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="523" mass="59461" checksum="729F117A830B5D69" modified="2005-04-26" version="1">MATRKVQQQTRQSSSPFWKARSVSQNYERTPNSPDQSLIVGASYSHANIPNGLSQHTRPRTPPRSSPNNSSHASPSTRRPGIWVASPRASYSGIMNQELGPWDHGNPAGKIGDDDDDDVGEDIVFDDDEDEFGLPSIASMRKRQGRQADVSRFKPVETPTFKSDSRPSTLDVNLPNNRQRANSSDIAEERDIPLYPTARKSDGKILRPQYKDILKDPANALNLINHVAPPKGASSKDMDAYTSRISRINKFKRLLQASTVPLQELRNLAWSGVPDEVRAMTWQLLLGYLPTNSERRIATLERKRKEYLDGVRQAFERSNAATTRENSRSTDTGRGRGLDEAIWHQISIDVPRTSPHIQLYSYEATQRSLERILYVWAIRHPASGYVQGINDLVTPLFQVFLGVYVTDLNVEEGMDPGQLPRSVLDAVEADSFWCLTKLLDGIQDNYIYAQPGIHRQVRALRDLTMRIDATLAKHLEQEGVEFMQFSFRWMNCLLMREMSVRNTIRMWDTYMAEEQGFSRFHLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="102" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AWH2</accession>
    <accession>C8VCJ2</accession>
    <name>Q5AWH2_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Hypothetical dihydroxy-acid dehydratase (Eurofung)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ANIA_07358</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IlvD/Edd family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF78550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_680627.1">
        <property type="nucleotide sequence ID" value="XM_675535.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AWH2"/>
    <dbReference type="STRING" id="227321.Q5AWH2"/>
    <dbReference type="GeneID" id="2869792"/>
    <dbReference type="KEGG" id="ani:ANIA_07358"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN7358"/>
    <dbReference type="eggNOG" id="KOG2448">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014271_3_1_1"/>
    <dbReference type="InParanoid" id="Q5AWH2"/>
    <dbReference type="OMA" id="HLIHWVA"/>
    <dbReference type="OrthoDB" id="3851628at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004160">
        <property type="term" value="F:dihydroxy-acid dehydratase activity"/>
        <property type="evidence" value="ECO:0000247"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009082">
        <property type="term" value="P:branched-chain amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0000247"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.30.80:FF:000003">
        <property type="entry name" value="Dihydroxy-acid dehydratase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.80">
        <property type="entry name" value="IlvD/EDD C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042096">
        <property type="entry name" value="Dihydro-acid_dehy_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020558">
        <property type="entry name" value="DiOHA_6PGluconate_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056740">
        <property type="entry name" value="ILV_EDD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000581">
        <property type="entry name" value="ILV_EDD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037237">
        <property type="entry name" value="IlvD/EDD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052352">
        <property type="entry name" value="Sugar_Degrad_Dehydratases"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004784">
        <property type="entry name" value="PRK06131.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009560">
        <property type="entry name" value="PRK13017.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43183:SF1">
        <property type="entry name" value="HYPOTHETICAL DIHYDROXY-ACID DEHYDRATASE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43183">
        <property type="entry name" value="HYPOTHETICAL DIHYDROXYACID DEHYDRATASE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24877">
        <property type="entry name" value="ILV_EDD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00920">
        <property type="entry name" value="ILVD_EDD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143975">
        <property type="entry name" value="IlvD/EDD N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00886">
        <property type="entry name" value="ILVD_EDD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dihydroxy-acid/6-phosphogluconate dehydratase N-terminal" evidence="6">
        <location>
            <begin position="100"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="Dihydroxy-acid/6-phosphogluconate dehydratase C-terminal" evidence="7">
        <location>
            <begin position="424"/>
            <end position="628"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF24877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBF78550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="651" mass="70599" checksum="507F180FCA939755" modified="2005-04-26" version="1">MPCQSKCEGCACGSASSQSASAVNIEDLDKELEALRKRTIELEKVRASAKKVSSLSSTLGAGRKLRSTTWFNSGDAGMTALYIERYLNYGVTREELMAGKPIIGIAQTGSDISPCNRYHIELAKRVREGIRTAGGIAFEFPTHPIQETSRRPTACIDRNLSYLGLVEILHGYPIDGVVLLTGCDKTTPACLMAAATMNIPAICMNVGPMINGYLKNELAGSGMVVWTGREMHAAGKLDDEGLVDLISRGAPSVGHCNTMGTASTMNALAEALGMALPGSAAIPAPYRERAQCAYKTGLQIVEMVHADRKPSDIMTREAFENVIAVNTAIGGSTNAPIHINAIAKHMGVDISLDDWDQLGFNIPLLLNMQPAGEFLGEEYYRAGGLPAIMAELLDAGKLHPDILTCNGHTVAENVKGHHSWDRRVIKPYSEPLMKDAGFVHLQGTLFESAIMKTCVISEQFRQHFLENPDDPNAFEGAVVVFDGPEDYHRRLEEAPINDKSILVMRGTGPLGYPGAAEVVNMHPPGHLLRQGIKSLPCIGDGRQSGTSGSPSILNASPEAAAGGNLALLRDGDRLRVDLNKRRVDILVSRKELDERRAALEAAGGYSIPESQTPWQELFRKETSQLNEGMVLREAVKYQRLAQRSETLRHNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AWR0</accession>
    <accession>C8VCU0</accession>
    <name>Q5AWR0_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ANIA_07270</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF78730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_680539.1">
        <property type="nucleotide sequence ID" value="XM_675447.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AWR0"/>
    <dbReference type="GeneID" id="2869963"/>
    <dbReference type="KEGG" id="ani:ANIA_07270"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN7270"/>
    <dbReference type="eggNOG" id="ENOG502SHMA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1194877_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AWR0"/>
    <dbReference type="OMA" id="CINAKSF"/>
    <dbReference type="OrthoDB" id="5391602at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF134">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="153"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="5"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBF78730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="232" mass="26056" checksum="35F7B67657F6A5EA" modified="2005-04-26" version="1">MLAVIGLGLTKASILILIRGIFSVSRPFRHLCNAMLFVVAAWTISFFFSNLFTCFPVTPLVEPFYGNKCINGLAMWYAGCISDVVVDLIILVIPLPMISQLKLPLRQKVAIGAIFLLGTTVVVISITRMAMYFHVGTTFREHYNDMTYYTSPVFFWTNIEISLAVILACLPTLRPVWTVLSGGRARKSSTYRPYDEIEPENSERMRRVKPTLDTIDRLESSIALVKVPAGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AWX6</accession>
    <accession>C8VD18</accession>
    <name>Q5AWX6_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Bifunctional oelate/linoleic acid delta desaturase (Eurofung)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_07204</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF78871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_664808.1">
        <property type="nucleotide sequence ID" value="XM_659716.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AWX6"/>
    <dbReference type="STRING" id="227321.Q5AWX6"/>
    <dbReference type="GeneID" id="2869952"/>
    <dbReference type="KEGG" id="ani:ANIA_07204"/>
    <dbReference type="eggNOG" id="ENOG502QQNB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033094_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AWX6"/>
    <dbReference type="OMA" id="DTVFVPW"/>
    <dbReference type="OrthoDB" id="1461976at2759"/>
    <dbReference type="BRENDA" id="1.14.19.6">
        <property type="organism ID" value="517"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006636">
        <property type="term" value="P:unsaturated fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd03507">
        <property type="entry name" value="Delta12-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012171">
        <property type="entry name" value="Fatty_acid_desaturase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32100">
        <property type="entry name" value="OMEGA-6 FATTY ACID DESATURASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="251"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid desaturase" evidence="2">
        <location>
            <begin position="65"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF78871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="394" mass="45459" checksum="04E44A1C00E1EA92" modified="2005-04-26" version="1">MAATATTLAEIEKTIKNAIPKHCFNRSLLISSAYVVRDLLYASVLFYFALHIDTLFSSQLLRILAWTAYGFMQGCVGTGIWILAHECGHGAFSPYQTWNDVVGWTLHSLLMVPYFSWKITHARHHRYTNNTERDTAFVPWTEKEYDTRPRYFPAWFEMFEDTPVYNLISLLAHQIAGWQMYLCFYVSAGAKSKPVPQGKQSGWFGGQQSASHFDPGSSLWTENQRHLIAISDLGLLLVAAANWYLAQQVGVLRMVLIYVVPYFWVHHWLVAITYLHHTHPSIPHYTDSTWTFTKGALSTVDRDFGFIGRHFFHHIIDHHVVHHLFNRIPFYHAEEATNAIIPVLGDMYHREETGFLWSLMETYKNCRFVGVENDVGKEGVLHWVFEEKKGAKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AWZ7</accession>
    <accession>C8VD39</accession>
    <name>Q5AWZ7_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_07183</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CBF78909.1"/>
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        <property type="nucleotide sequence ID" value="XM_659695.2"/>
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        <property type="component" value="Chromosome IV"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
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        <location>
            <begin position="18"/>
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            <begin position="30"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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            <dbReference type="EMBL" id="CBF78909.1"/>
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    <sequence length="186" mass="20759" checksum="B9BAE78815EFFD8B" modified="2005-04-26" version="1">MSGSFDNNDLRQAGTAAKRVHDHKAKWVHGGRSARPGAAAPNGILPITRPAKQQSQANEHRTSWTRRQRLRDAQHSSTLAKVNFRNDVREALDEATSESSGVEDHEVLAVAATIPEVYQAEGPVDLYEVSGETLFNAVVDKAVEKFEIKETEKLVKEYEVITRDHELSIGYLADEDEFELVDHVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="118" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AX37</accession>
    <accession>C8VD82</accession>
    <name>Q5AX37_EMENI</name>
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        <submittedName>
            <fullName evidence="6">Ribosome associated DnaJ chaperone Zuotin, putative (AFU_orthologue AFUA_4G03650)</fullName>
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        <name evidence="6" type="ORF">ANIA_07143</name>
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    <organism evidence="6 7">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
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            <dbReference type="DOI" id="10.1038/nature04341"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
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    <reference evidence="7" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
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                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
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                <person name="Cornell M.J."/>
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            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
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            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
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        <subcellularLocation>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBF78988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="447" mass="51559" checksum="84E9F4CB0CBAACE7" modified="2005-04-26" version="1">MSSAQVVELTLPALPAGWSADKEFKAVGKLSAATQRNLEPVGPHFLAHARRKRHHRTFSEDERIQAQQNVKKTEEEEDDEISEDEDPMMLQRDAKDWKSQDHYAVLGLSKYRWRATPDQIKRAHRKKVLRHHPDKKAALGDRDENDSFFKCIQKATEILSDPVKRRQFDSVDEAADVEPPSKKETQKGNFYKLWRPVFESEARFSKIQPVPQLGDENSTFEEVNEFYNFWYNFDSWRTFEYLDEDVPDDNENRDQKRHVEKKNANARRKRKTEDTARLRRLVDDCAALDERIKKFRKAARADKDKKRLEKEAEAKRIAEEKEKARLEEEQRKKEAEEAAKADREKAKKAKEAAKNAAKKNKRVLKGSVKDVNYFAESGEPSAAQVDSVLTDVDLINSKIDNEELASLAERLTAAGKDAAAVKNVYTEEIKRLVAAGKAKEGEVKFFV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-09-11" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AXH3</accession>
    <accession>C8VC91</accession>
    <accession>Q9Y8F5</accession>
    <name>TOF1_EMENI</name>
    <protein>
        <recommendedName>
            <fullName>Topoisomerase 1-associated factor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">tof1</name>
        <name type="synonym">mdrA</name>
        <name type="ORF">AN7007</name>
    </gene>
    <organism>
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="1998-06" db="EMBL/GenBank/DDBJ databases">
            <title>Cloning, sequencing, and functional analysis of mdrA, an Aspergillus nidulans drug resistance gene.</title>
            <authorList>
                <person name="Cheong C."/>
                <person name="Kang H.-S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in chromosome segregation during meiosis and DNA damage repair.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the timeless family.</text>
    </comment>
    <comment type="sequence caution" evidence="3">
        <conflict type="erroneous gene model prediction">
            <sequence resource="EMBL-CDS" id="AAD41625" version="1"/>
        </conflict>
    </comment>
    <comment type="sequence caution" evidence="3">
        <conflict type="erroneous gene model prediction">
            <sequence resource="EMBL-CDS" id="CBF79271" version="1"/>
        </conflict>
    </comment>
    <comment type="sequence caution" evidence="3">
        <conflict type="erroneous gene model prediction">
            <sequence resource="EMBL-CDS" id="EAA61653" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EMBL" id="AF072683">
        <property type="protein sequence ID" value="AAD41625.1"/>
        <property type="status" value="ALT_SEQ"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AACD01000117">
        <property type="protein sequence ID" value="EAA61653.1"/>
        <property type="status" value="ALT_SEQ"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF79271.1"/>
        <property type="status" value="ALT_SEQ"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_664611.1">
        <property type="nucleotide sequence ID" value="XM_659519.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AXH3"/>
    <dbReference type="SMR" id="Q5AXH3"/>
    <dbReference type="FunCoup" id="Q5AXH3">
        <property type="interactions" value="51"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5AXH3"/>
    <dbReference type="GeneID" id="2870083"/>
    <dbReference type="KEGG" id="ani:ANIA_07007"/>
    <dbReference type="eggNOG" id="KOG1974">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004390_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AXH3"/>
    <dbReference type="OrthoDB" id="310853at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031298">
        <property type="term" value="C:replication fork protection complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000076">
        <property type="term" value="P:DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043111">
        <property type="term" value="P:replication fork arrest"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044998">
        <property type="entry name" value="Timeless"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007725">
        <property type="entry name" value="TIMELESS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006906">
        <property type="entry name" value="Timeless_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22940:SF4">
        <property type="entry name" value="PROTEIN TIMELESS HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22940">
        <property type="entry name" value="TIMEOUT/TIMELESS-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04821">
        <property type="entry name" value="TIMELESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05029">
        <property type="entry name" value="TIMELESS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0236">DNA replication inhibitor</keyword>
    <keyword id="KW-0469">Meiosis</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000301739" description="Topoisomerase 1-associated factor 1">
        <location>
            <begin position="1"/>
            <end position="1167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="332"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="563"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="889"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="981"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1105"/>
            <end position="1167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="572"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="583"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="949"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="959"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="996"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1062"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1078"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1110"/>
            <end position="1127"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; AAD41625." evidence="3" ref="1">
        <original>E</original>
        <variation>V</variation>
        <location>
            <position position="635"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; AAD41625." evidence="3" ref="1">
        <original>L</original>
        <variation>C</variation>
        <location>
            <position position="1016"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="1167" mass="134367" checksum="3234327D27F1BA6A" modified="2007-09-11" version="2">MEEAVPAQTVEVIDPEVRAHVYSLLGGFNGEDADKYVLGDDALSCLRDIKRWLKLYDEKFNRMDVARCLGEANLVNGDLIQILSLWWREGQQSKYMTRIALACVELLVPLTWPLEIHGEMTVNHHRHIPYLQQAQVGYKRGILNMASCGILRAVIRIGLPSMAIPPSERTARDEGILKIMLYLLRNIAIITANARLAAEGEEEETSRSATINAFHDQDVFALLLTLCSNVSDDFNMLDIPLLEILFHMVRGIDVEKLFMNDAQRSAKRTDELNDLLRQESSMRREYAKNAPTRHGRFGTMIWVKRDDAKMSTVSGQDVLRDEQTTLYKMDQSKRWNKPRRGRKAQDMSVNNDFNTPVHISPSATTNLRMFVEEFLDSGFNPLFVHVRKAIERESIRVLDINKRHFLYTVSWFLGAERARRARQREKYAQSGKKPDNELEPDSFGLVAGVLNQETFVFLNRSMQNSLDNKEWDDLNAAMRCFTQILLTVQEMSQSPLEEDQEIAENIQNRIFYEETTHDRILAILRGYTDQGFGYLDACTELSHVFLRMLERYSKTNVDMQVRSRRRARKRKREEQLVNKGSDEEQESEDEDYAEAEKMSKERKFDFTRFAAKFSNQKCVDTFVAFTKFYKELNNEQLKRAHRYFYRIAFKQEMTVLLFRVDILNLFYRIIKGPGGMDSSKPIYKEWEELVRQLIRRLIKKLEQRPALITELLFSKINSTAFYLEYGFEKQTVTTSKRAPAELEVDPKAASTPEEKLSIVVAALVKDEQSALVKWISEVLGSAADEREAWELNSHDVDLAGPRDTQNPIITVKSQDNSFKRAMFQNAKLRLLMTLLKFDRLGQENVEGISWIIPSELKSDELRESKAVIDKALLIGNTDERDPNDLLRKKYSHEPRDGFSGQNLDVNFGSDSEGEDVIPDGPLFPANPRSKAHALNELKQKRKKRKDKGEEEPVDEETLEERRQARLENTRWRLAKIKSDLYVHASDEESDAEADQEFFRLEEERRNEQSERIKKALLLGRTEDAGNKARQRKRGKRSNEPNIAGEEETSGKRRRHSGGTNVELEEDDILMDDMEMPSRASSGEYSSNDADAIDKSMAAAEDELYFDDDLAFGRDRDKDETSVDRDGADASSPRKHNDGSESAEEDIPLAPPNRRRLRAGFVVESDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AXL3</accession>
    <accession>C8V3F4</accession>
    <name>Q5AXL3_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase/retrotransposon-derived protein RNase H-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ANIA_06967</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF71850.1"/>
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        <property type="nucleotide sequence ID" value="XM_659479.1"/>
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    <dbReference type="AlphaFoldDB" id="Q5AXL3"/>
    <dbReference type="STRING" id="227321.Q5AXL3"/>
    <dbReference type="GeneID" id="2870444"/>
    <dbReference type="KEGG" id="ani:ANIA_06967"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN6967"/>
    <dbReference type="eggNOG" id="KOG0017">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_206742_1_0_1"/>
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    <dbReference type="OrthoDB" id="4505067at2759"/>
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        <property type="component" value="Chromosome I"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF71850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="50" mass="5755" checksum="A9FD03D9BF3024AA" modified="2005-04-26" version="1">MDPEKVKAIKEWETPTIIKGVRGFLGFANFYRRFIPNFSGIQPSTLPTVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AXQ4</accession>
    <accession>C8V357</accession>
    <name>Q5AXQ4_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_06926</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF71756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_664530.1">
        <property type="nucleotide sequence ID" value="XM_659438.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AXQ4"/>
    <dbReference type="GeneID" id="2870640"/>
    <dbReference type="KEGG" id="ani:ANIA_06926"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1004826_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AXQ4"/>
    <dbReference type="OMA" id="TGIFFAC"/>
    <dbReference type="OrthoDB" id="2544694at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF71756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="277" mass="31590" checksum="F273F875EF83AC4C" modified="2005-04-26" version="1">MVEKPETERVEETTTVDDKDEANSKGQPLMRSELDNLSIWESLRRYKVVTTIAMVAAFKINLNGGLVSNKGFIRQMTDPETSIIEGNRSIRTQGRSLYHLPRLCDRLKLTGWSWFVIGQLFASVALDRLNASDPYNFRTPIYTQGIMTATIATERSIAARDKQQGRWAVFQGRNLLRFIIAGWPKITQQFVGLSVFNSNVTYFYLLRLSRYLFDNRFAATGSISVVIAWFILPEVTRRTPAEIDELFEKKVKLRKFDKYVTDVQINAAGQEKGDGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="120" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AXR5</accession>
    <accession>C8V2Z4</accession>
    <name>Q5AXR5_EMENI</name>
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        <submittedName>
            <fullName evidence="8">Thioredoxin, putative (AFU_orthologue AFUA_5G13640)</fullName>
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    <gene>
        <name evidence="8" type="ORF">ANIA_06915</name>
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            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
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            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DeSI family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF71724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_664519.1">
        <property type="nucleotide sequence ID" value="XM_659427.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AXR5"/>
    <dbReference type="STRING" id="227321.Q5AXR5"/>
    <dbReference type="GeneID" id="2870622"/>
    <dbReference type="KEGG" id="ani:ANIA_06915"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN6915"/>
    <dbReference type="eggNOG" id="KOG0324">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0907">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033441_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AXR5"/>
    <dbReference type="OMA" id="VTLQMAC"/>
    <dbReference type="OrthoDB" id="21221at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032434">
        <property type="term" value="P:regulation of proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1720.30">
        <property type="entry name" value="PPPDE domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008580">
        <property type="entry name" value="PPPDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042266">
        <property type="entry name" value="PPPDE_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013535">
        <property type="entry name" value="PUL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12378">
        <property type="entry name" value="DESUMOYLATING ISOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12378:SF7">
        <property type="entry name" value="DESUMOYLATING ISOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05903">
        <property type="entry name" value="Peptidase_C97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08324">
        <property type="entry name" value="PUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01179">
        <property type="entry name" value="DUF862"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51858">
        <property type="entry name" value="PPPDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51396">
        <property type="entry name" value="PUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPPDE" evidence="7">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="5">
        <location>
            <begin position="144"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="PUL" evidence="6">
        <location>
            <begin position="283"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="148"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBF71724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="585" mass="64193" checksum="1CDC1866BF40446B" modified="2005-04-26" version="1">MDIELYVYDLSQGLARMYSMALTGVQIDAIYHTSLVFNNTEYYFGQGIQTAQPSSTHHGQPMEKIHIGTSELPLEVVEEYLQSLSSIYTPESYDLFLHNCNNFTQDLAMFLVGKSIPEHIRNLPTTFLSTPFGQMLKPQIESALRGVTQAPGQGLPAPRSGPAGSHTQAQAQSQGKVRVVGSLNELEQHLSSASKSCAVIFFTSATCPSCKMMYPVYDELAAEAGSKAVLLKVDTSMAHDVAVRYGVHATPTFMTFLRGEKLDTWAGADAGKLRGNVRLLLEMAYPTHPHRELRLPSFQRTITNYVTYNKTPPLEKLMQKLKPHDQDPTLLAIIDFIKHRTTSSSADTPLPSDLPTFATYLAQTFHSTPQENRFALVDLVRVLFVDPRVAAYFGEDTSHTLLLTFFSTSEDEATSYSLRIVTLQLACNLFKTPVYTNHLSSPSNPLRPALLSLVTSSLLNAQSNLRVVAASLAYNLAALNHNARFANTGSEPLTEEEQVALTASVAEALAQESSSTEALHGLLFSLGLLIYEVPMDGAVIDLCRALNLKEAVEGKKELITNGDQGKDKGDSLFREVGRELLAKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="126" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AXY9</accession>
    <accession>C8V2I2</accession>
    <name>Q5AXY9_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Mitochondrial inner membrane protease subunit 1, putative (AFU_orthologue AFUA_5G12820)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ANIA_06841</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase S26 family. IMP1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF71570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_664445.1">
        <property type="nucleotide sequence ID" value="XM_659353.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AXY9"/>
    <dbReference type="FunCoup" id="Q5AXY9">
        <property type="interactions" value="386"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5AXY9"/>
    <dbReference type="GeneID" id="2870535"/>
    <dbReference type="KEGG" id="ani:ANIA_06841"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN6841"/>
    <dbReference type="eggNOG" id="KOG0171">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028723_4_3_1"/>
    <dbReference type="InParanoid" id="Q5AXY9"/>
    <dbReference type="OMA" id="LCKGPSM"/>
    <dbReference type="OrthoDB" id="308440at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042720">
        <property type="term" value="C:mitochondrial inner membrane peptidase complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006627">
        <property type="term" value="P:protein processing involved in protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.109.10:FF:000015">
        <property type="entry name" value="Mitochondrial inner membrane protease subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.109.10">
        <property type="entry name" value="Umud Fragment, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052064">
        <property type="entry name" value="Mito_IMP1_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000223">
        <property type="entry name" value="Pept_S26A_signal_pept_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019758">
        <property type="entry name" value="Pept_S26A_signal_pept_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12383:SF16">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12383">
        <property type="entry name" value="PROTEASE FAMILY S26 MITOCHONDRIAL INNER MEMBRANE PROTEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10502">
        <property type="entry name" value="Peptidase_S26"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00727">
        <property type="entry name" value="LEADERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="LexA/Signal peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00761">
        <property type="entry name" value="SPASE_I_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S26" evidence="9">
        <location>
            <begin position="30"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S26" evidence="9">
        <location>
            <begin position="124"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600223-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBF71570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="182" mass="20274" checksum="A859622D0EF73248" modified="2005-04-26" version="1">MPSKAESLFRSLLRHSTPRHVLRSLYFGTGAFCAAALFWENVLMFQLAEGPSMYPTFNPRGDYLLVSRLHKHGRGIEVGDVVRFYHPSFLGMHGAKRVIGLPGDFVCRDHPLSTDVGGSGEMIRVPEGHVYVCGDNLPWSRDSRTFGPLPMGLINGKVIARIWPLSKVQWVTNTLKPVEAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AY03</accession>
    <accession>C8V2G7</accession>
    <name>Q5AY03_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SsDNA binding protein Ssb3, putative (AFU_orthologue AFUA_5G12895)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ANIA_06827</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the replication factor A protein 3 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF71541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_664431.1">
        <property type="nucleotide sequence ID" value="XM_659339.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AY03"/>
    <dbReference type="STRING" id="227321.Q5AY03"/>
    <dbReference type="GeneID" id="2870505"/>
    <dbReference type="KEGG" id="ani:ANIA_06827"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN6827"/>
    <dbReference type="eggNOG" id="ENOG502SBIR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_141922_2_0_1"/>
    <dbReference type="InParanoid" id="Q5AY03"/>
    <dbReference type="OMA" id="HRYKEIF"/>
    <dbReference type="OrthoDB" id="188186at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005662">
        <property type="term" value="C:DNA replication factor A complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd04479">
        <property type="entry name" value="RPA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000271">
        <property type="entry name" value="Similar to ssDNA binding protein Ssb3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013970">
        <property type="entry name" value="Rfa2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15114:SF1">
        <property type="entry name" value="REPLICATION PROTEIN A 14 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15114">
        <property type="entry name" value="REPLICATION PROTEIN A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08661">
        <property type="entry name" value="Rep_fac-A_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBF71541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="122" mass="13139" checksum="113D936FE25A8CF5" modified="2005-04-26" version="1">MSLQTPRVLPSHLHAFNPSTSGPRSAPPVRLLGTVTALHGDTATITCGTHGDVTLILKPDSHLQMGKLVEVVGKVAEIDGGLGIRVLATTDWGNPADCDYKIYEKVVDVTHRLKPIFYESPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AY28</accession>
    <accession>C8V293</accession>
    <name>Q5AY28_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Subtilisin-like serine protease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_06802</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
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            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
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        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
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<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="108" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AYD5</accession>
    <accession>C8V1N0</accession>
    <name>Q5AYD5_EMENI</name>
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            <fullName evidence="5">Nonsense-mediated mRNA decay factor (Upf2), putative (AFU_orthologue AFUA_7G05430)</fullName>
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        <name evidence="5" type="ORF">ANIA_06695</name>
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        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
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    <reference evidence="6" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
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                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
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            <dbReference type="DOI" id="10.1038/nature04341"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
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    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
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                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
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            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
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        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
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    </reference>
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        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
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        <source>
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        </source>
    </evidence>
    <sequence length="1170" mass="132239" checksum="C38F56898C3F3D34" modified="2005-04-26" version="1">MTKSKHLNSGGPVQRLNCSILQGKGSEFITAGIATLQPGGKRMDRQRKHIFPVSKSLDSSLKKNTAFIKRLRTGINAAAQQTLLTDIRTLSLHKYLSEIISACYEGLCKLKSPGEITAGVEITSALHQRFGPAEFTRQIGWLLGRGLSSPDKSQLKTLSQELREREEKERLSRHRVLLKVVTELWLVGVLRTLDDVERPEDVGSKGKDGAGLGNKVVDGVSRNRNPAGDKEPEPFPLEVLKDLLGHDRDHSNLPLALLFAKSFSWDVLGAKAAEEGRKTVEADGATAMPAETQNGDEATAEDDTPLAPEKIQVRFKSILNRYLEDVKAHVMRDQKALTAQSRRNAEAYVKSGEIFEDRQANFERQTKSLEKLVANTQVLCEILGVEMPALATQEASDPAASGGIGLVKTSEYLRGQGEGPGIWEDEEERRFYENLVDLKGKVPAVLLDDGKKKKTETGEPTKKKESEAGHESSEKTEPQSQISEERTTEADDQSMAIASKTVGAQVDALLAKLPELQTKEQVDQMALDFCFLNSKASRNRLVKAISDIPKGRIDLLPLYSRLVATLGQYMPDIPQGLTTYLDEEFRSLQRRKSKEFLGQVRMSNIRYLAELTKFGVVPEHIIFHCFKVSLDDFSRMNIEIIGHLLENCGRYLLRNPDTSPRMASFLETLGRKKTVQHLGPQERMIIENAVYYVDPPQRPAIQQKERTPMESYIRKLIYLDMNKRNYTKILKSVRKLHWEEPEVVHILERVFSKPAKVKYGNIHLLAILVSALYRYHQGFVIGIVDNILEYITLGLEQNDFKFNQKRIAEVKYLGELYNYKMIDSPVIFDTLYRIVTYGHEGGTPMPGKINVLDMPDDFFRIRLVCQLLDTCGHCFDRGSAKKKLDFFLKFFQYYICTKDPLPMDIDFLVQDTYSLTRPQWTLVTELDEASRIFGEAVAQNFKPQEEKPEPEEESEDSGSDEDLEEDAFPEADEEGESSDEADVSPNAERNDDSESEEEQIFVTRQEEERDPEAEAEFDREFEKMMAESVESRKFERKAVFDIPLPMRRAARDPTAEVTAANSTPAPVSSPAQSSGTMAFSLMTKKGNKQQTRTIDLPSDSTFAVAMRSQQQADREEQQRIKNLVLNYEMSNETDSTEEPVEKRSPARVDKSGTNRSAFRSRKLQLSDVNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B0J4</accession>
    <accession>C8V3I4</accession>
    <name>Q5B0J4_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">TIL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ANIA_05936</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF70531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_663540.1">
        <property type="nucleotide sequence ID" value="XM_658448.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B0J4"/>
    <dbReference type="GeneID" id="2870822"/>
    <dbReference type="KEGG" id="ani:ANIA_05936"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN5936"/>
    <dbReference type="HOGENOM" id="CLU_156801_2_1_1"/>
    <dbReference type="InParanoid" id="Q5B0J4"/>
    <dbReference type="OMA" id="NETFLPC"/>
    <dbReference type="OrthoDB" id="4438874at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030414">
        <property type="term" value="F:peptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19941">
        <property type="entry name" value="TIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036084">
        <property type="entry name" value="Ser_inhib-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051368">
        <property type="entry name" value="SerProtInhib-TIL_Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002919">
        <property type="entry name" value="TIL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23259">
        <property type="entry name" value="RIDDLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23259:SF82">
        <property type="entry name" value="SERINE PROTEASE INHIBITOR 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01826">
        <property type="entry name" value="TIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57567">
        <property type="entry name" value="Serine protease inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010346608" description="TIL domain-containing protein" evidence="4">
        <location>
            <begin position="17"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="TIL" evidence="5">
        <location>
            <begin position="25"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="74"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBF70531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="117" mass="12581" checksum="91E0A560012613A0" modified="2005-04-26" version="1">MKYFLVLAALAAGVMAYEAVSSPPCNEYEVHKDCGSACHPTCETFEDDVNICTLQCVIGCYCKDGLYRTEVANSGACVPGDKCKQGQGDGRSESDYGDEGGDEDAGEDADEDTWSYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="101" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B0X4</accession>
    <accession>C8V098</accession>
    <name>Q5B0X4_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">RNA polymerase II transcriptional coactivator, putative (AFU_orthologue AFUA_2G07460)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ANIA_05806</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transcriptional coactivator PC4 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF70810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_663410.1">
        <property type="nucleotide sequence ID" value="XM_658318.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B0X4"/>
    <dbReference type="STRING" id="227321.Q5B0X4"/>
    <dbReference type="GeneID" id="2871080"/>
    <dbReference type="KEGG" id="ani:ANIA_05806"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN5806"/>
    <dbReference type="eggNOG" id="KOG2712">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104273_0_0_1"/>
    <dbReference type="InParanoid" id="Q5B0X4"/>
    <dbReference type="OMA" id="NPFWELS"/>
    <dbReference type="OrthoDB" id="2505440at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060261">
        <property type="term" value="P:positive regulation of transcription initiation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.31.10:FF:000006">
        <property type="entry name" value="Putative RNA polymerase II transcriptional coactivator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.31.10">
        <property type="entry name" value="Transcriptional Coactivator Pc4, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003173">
        <property type="entry name" value="PC4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009044">
        <property type="entry name" value="ssDNA-bd_transcriptional_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045125">
        <property type="entry name" value="Sub1/Tcp4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13215">
        <property type="entry name" value="RNA POLYMERASE II TRANSCRIPTIONAL COACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02229">
        <property type="entry name" value="PC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54447">
        <property type="entry name" value="ssDNA-binding transcriptional regulator domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcriptional coactivator p15 (PC4) C-terminal" evidence="8">
        <location>
            <begin position="57"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="123"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBF70810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="168" mass="18742" checksum="BA982C9F9974123E" modified="2005-04-26" version="1">MASQSRKRVSEVVDHSLVDKPPLSKKSRTNAPDVAGFDNSRPELVARKEDSNGDIYWEISKMRRVTISSFRGKTMVNIREYYEKDGEELPGKKGISLPIDQFSSLVTLLPEIEIVLQEKGLSIPRPKYVGQGTSTGGNDKKDSTDGLPMARPSRENIEATSDEDEDEE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-09-13" modified="2026-01-28" version="102" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B1X8</accession>
    <accession>C8VGG8</accession>
    <name>RSE1_EMENI</name>
    <protein>
        <recommendedName>
            <fullName>Pre-mRNA-splicing factor rse1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">rse1</name>
        <name type="ORF">AN5452</name>
    </gene>
    <organism>
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in pre-mRNA splicing and cell cycle control.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RSE1 family.</text>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="erroneous gene model prediction">
            <sequence resource="EMBL-CDS" id="EAA62612" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EMBL" id="AACD01000094">
        <property type="protein sequence ID" value="EAA62612.1"/>
        <property type="status" value="ALT_SEQ"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF81885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B1X8"/>
    <dbReference type="SMR" id="Q5B1X8"/>
    <dbReference type="FunCoup" id="Q5B1X8">
        <property type="interactions" value="1277"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5B1X8"/>
    <dbReference type="EnsemblFungi" id="CBF81885">
        <property type="protein sequence ID" value="CBF81885"/>
        <property type="gene ID" value="ANIA_05452"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AN5452"/>
    <dbReference type="eggNOG" id="KOG1898">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003246_0_0_1"/>
    <dbReference type="InParanoid" id="Q5B1X8"/>
    <dbReference type="OMA" id="PRATGHW"/>
    <dbReference type="OrthoDB" id="436637at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030620">
        <property type="term" value="F:U2 snRNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001143">
        <property type="entry name" value="Pre-mRNA-splicing factor rse-1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000068">
        <property type="entry name" value="Pre-mRNA-splicing factor rse1, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018846">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058543">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050358">
        <property type="entry name" value="RSE1/DDB1/CFT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004871">
        <property type="entry name" value="RSE1/DDB1/CPSF1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10644">
        <property type="entry name" value="DNA REPAIR/RNA PROCESSING CPSF FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10433">
        <property type="entry name" value="Beta-prop_RSE1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23726">
        <property type="entry name" value="Beta-prop_RSE1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03178">
        <property type="entry name" value="CPSF_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0507">mRNA processing</keyword>
    <keyword id="KW-0508">mRNA splicing</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0747">Spliceosome</keyword>
    <feature type="chain" id="PRO_0000218631" description="Pre-mRNA-splicing factor rse1">
        <location>
            <begin position="1"/>
            <end position="1209"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="1209" mass="133003" checksum="07475892F783A827" modified="2011-11-16" version="2">MATTSHMFMYSLTIQPPTAITQAILGQFAGTKEQQIVTASGSKLTIHRPDPTQGKVIPLYTQDVFGIIRTLAAFRLAGSNKDYIIIGSDSGRITIIEYVPSQNRFNRIHLETFGKSGVRRVVPGQYLAVDPKGRACLIASVEKNKLVYVLNRNSQAELTISSPLEAHKPQTLVYSVVALDAGYENPVFAALEVDYSESDQDPTGRAYEEVEKLLVYYELDLGLNHVVRKWTDPVDRTSSMLFQVPGGADGPSGVLVCAEDNITYRHSNQDAFRVPIPRRKGAMENPERKRCITAGVMHKMRGAFFFLLQTEDGDLFKLTLDMVEDDKGQLTGEVKGLKIKYFDTVPLASSLLILKSGFLYVAAEGGNHHFYQFEKLGDDDEETEFNSDDFSADPAAPCTPVYFQPRGAENLNLVEAINSLNPLVDSKVVNISEDDAPQIFTVSGTGARSTFRTLKHGLEVSEIVESELPSVPSAVWTTKLTRADEFDAYIVLSFANGTLVLSIGETVEEVTDTGFLSSAPTLAVQQLGEDSLIQIHPRGIRHILADRRVNEWPAPQHRSIVAAATNERQVAVALSSGEIVYFELDADGSLAEYDERRQMSGTVTCLSLGEVPEGRVRSSFLAVGCDDSTVRILSLDPDTTLENKSVQALTAAPSALNIIAMADSSSGGTTLYLHIGLHSGVYLRTALDEVTGELSDTRTRFLGSKAVKLFQVSVTGQTAVLALSSRPWLGYSDTQTKGFMLTPLDYVGLEWGWNFSSEQCVEGMVGIQGQNLRIFSIEKLDNNMLQQSIPLAYTPRHFIKHPEEPLFYVIEADNNVLSPATRARLLEDSKARGGDTTVLPPEDFGYPRGTGHWASCIQIIDPLDAKAVVGAVELEENEAAVSIAAVPFTSQDDETFLVVGTAKDMTVNPPSSAGGYIHIYRFQEDGKELEFIHKTKVEEPPLALLGFQGRLLAGVGSVLRIYDLGMKQLLRKCQAAVAPKAIVGLQTQGSRIVVSDVRESVTYVVYKYQDNVLIPFVDDSIARWTTAATMVDYETTAGGDKFGNLWLVRCPKKASEEADEEGSGAHLIHDRGYLQGTPNRLELMIHVFTQDIPTSLHKTQLVAGGRDILVWTGFQGTIGILVPFVSREDVDFFQSLEMQLASQCPPLAGRDHLIYRSYYAPVKGVIDGDLCEQYFLLSNDTKMMIAAELDRSVREIERKISDMRTRVAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B1Y2</accession>
    <accession>C8VGH2</accession>
    <name>Q5B1Y2_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_05448</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF81892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_663052.1">
        <property type="nucleotide sequence ID" value="XM_657960.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B1Y2"/>
    <dbReference type="GeneID" id="2871739"/>
    <dbReference type="KEGG" id="ani:ANIA_05448"/>
    <dbReference type="eggNOG" id="ENOG502QT51">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007122_1_0_1"/>
    <dbReference type="InParanoid" id="Q5B1Y2"/>
    <dbReference type="OMA" id="GPMNVLV"/>
    <dbReference type="OrthoDB" id="4155914at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="662"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="71"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="184"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="215"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="358"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="393"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="667"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="685"/>
            <end position="700"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF81892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="805" mass="88417" checksum="6D55F4C24E6D41A3" modified="2005-04-26" version="1">MPLFRRKEKSKPSISSPAFQSDEHLPPYPPSSSSSAAPPFDSDDSSGNHHHHHQHHHFPVSTPPQFPPHPQSQSQSHHSNTFSQPQSQTQSPYSWDSRQPPPRNPARTGLQRSHTQRLRTPPDVSTLHNSHSTITVVTNSPSPSPHLAPPQSFDGIDADVSDQSGPSSPTDKLDDQEPRRSKRSFFSFHSSASSTSVRDQPSLLERNRSVKLPTRRSQPQHQPHYHQQQQSPQLPQQSRSSLDWSREYAVDAPEAEYRTPSMPQQNSARAPDPALAPHARSPRTSPLPRSNTDPRLADELYRQSSVDNSRHGAELTPGANQLDPRPPSRQSLEPPSPYQFPRSETSSVTQLPAMSDRPSGSNSQNPAQQQGSSQNNAGQQQASLDPGRATPTSKDRNRDDLSEADVRTILQKYDELQAKYSKVKRYYFERDAQVQQLQNTVAHQRMAVSRTVLDDNEYANRFGRLDGAIKDLAFSIRKDWKTLPTWLSGFVNEDAPATGTKEMTAIGRSVMSRWLVDEIFERYFHPALEPSFSQQLKSIEMTLRRQHTNIATDEDKENSIARISNWRRTTLDGLGDSLQGPAADEYRSGLINCLVDNLVATLVSYLQSPPPPGIDNGARMIVENAIGIAEKIPLESRDICVEYIPPGSPIHEATMKIESGVLPPLTNAASPSDTQTSTELPSNRSSHEDGPGNADNDRDSQLASTNPSAHDSGPAREQRMRSVFSNIMGRKPGQGPPQTGSGPGPTPASMGNDGSRRGSVTPAASAASGQGSGTGRIRLAAFVTAEVRGRGPMNVLVKAPAYPMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="127" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B2L4</accession>
    <accession>C8VF92</accession>
    <name>Q5B2L4_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Single-stranded DNA endonuclease (Eurofung)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">ANIA_05216</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="17">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Single-stranded DNA endonuclease involved in excision repair of DNA damaged with UV light, bulky adducts, or cross-linking agents. Essential for the incision step of excision-repair.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the XPG/RAD2 endonuclease family. XPG subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF81100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_662820.1">
        <property type="nucleotide sequence ID" value="XM_657728.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B2L4"/>
    <dbReference type="FunCoup" id="Q5B2L4">
        <property type="interactions" value="512"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5B2L4"/>
    <dbReference type="GeneID" id="2871507"/>
    <dbReference type="KEGG" id="ani:ANIA_05216"/>
    <dbReference type="eggNOG" id="KOG2520">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003018_0_0_1"/>
    <dbReference type="InParanoid" id="Q5B2L4"/>
    <dbReference type="OMA" id="PNSMDFS"/>
    <dbReference type="OrthoDB" id="31113at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901255">
        <property type="term" value="P:nucleotide-excision repair involved in interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd09904">
        <property type="entry name" value="H3TH_XPG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09868">
        <property type="entry name" value="PIN_XPG_RAD2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000092">
        <property type="entry name" value="DNA excision repair protein Rad2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000025">
        <property type="entry name" value="DNA repair protein RAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000061">
        <property type="entry name" value="Single-stranded DNA endonuclease (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001044">
        <property type="entry name" value="XPG/Rad2_eukaryotes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019974">
        <property type="entry name" value="XPG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16171">
        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-G CELLS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16171:SF7">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02809">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00066">
        <property type="entry name" value="XRODRMPGMNTG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00726">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00841">
        <property type="entry name" value="XPG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00842">
        <property type="entry name" value="XPG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 16" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="15">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="XPG-I" evidence="14">
        <location>
            <begin position="817"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="115"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="516"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="601"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1026"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="601"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="629"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1029"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1058"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="1072"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="1095"/>
            <end position="1107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="1130"/>
            <end position="1141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00053135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CBF81100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="1141" mass="128014" checksum="4BBB82B74D3E4EBC" modified="2005-04-26" version="1">MGVQGLWTIVQPCARPVKLETLNRKRLAVDASIWIYQFLKAVRDKEGNALRNSHIVGFFRRICKLLYFGIKPVFVFDGGAPVLKRQTIANRKKRREGRREDAVQTASKLLAVQLQRTAEQESAKRRSRRQENEEDVPDNPVYVEETFMTDKQKQQSRTFKKKDAYHLPDMQVSLQEMGAPNDPRIMSQEELEEYARQFHQGEDINLYDFSKIDFDSPFFLSLPATDRYNILNAARLRSRLRMGYSKEQLDTMFPDRMAFSKFQIERVKERNDLTQRLMNINGMNGDEAFYKSGQRIAGERGKEYVLVQDNSVEGGWVLGVVGNKEGGREEKPIDVDRYFHHEITPEPEASEDEGGFEDVPIEGLNRLPKLSFLQPGVFDDSLRQHIQGSQGQDAGADSLFVEDFNNAQHTGDVFDGAAASEDEDLQRAIAMSLQSPNHMDHDAEMPEIPVNRATSLEPQSKPAVEPTIESDDELDFVAAVAQSKRTKAPAKPAPTQTFEGPLPFETLKHRKPLNVKKPEPVENDAGGFEKGPSKEAKENVPLPPWFSGPQQNSEFIADQNDNDLDNYRDRAMTPGHLFLRNHRSPSVIDVDKFPESKVIDLDPAPEADKETAPAQPAELKEIQTPPEPPKPESPDHRASVALEAKVAKDGDVAESVQTDGEESVRSSSPEFEDVTVQPVEAVPAAERERSLEFEDVHLPAEEHVGDGEKTGRLSPEFEDVPIQQVPSALHEVGLAQAVDIDDEGFSDPEDEELMRQLAAEGEEHVRFAATLNSAPHSEGTFDYEQELKQLRSQQKKDRRDADEVTQIMITECQQLLRLFGLPYITAPMEAEAQCAELVSLGLVDGIITDDSDIFLFGGTRVYKNMFNQSKYVECYLTADLEKEYALHRRKLISFAHLLGSDYTEGIPGIGPVTALEILTEFSSLEEFRDWWTQVQTGADMSNSSHAAFYKKFRKQATKIFLPPTFPDARVDAAYLEPEADRDPSPFQWGVPDLHGLRNFLMATIGWSQERTDEVLVPVIRDINQREQEGTQSNITSFFSGPQGAGAFAPRVRSGGQSRMEKAFSRLRREAGADQDAELVDVETDPSSQDLSALPARRKGKGTRKGAKRGAEPEEAAENGQGSRENDGATAKKRRGRKEAKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B322</accession>
    <accession>C8V823</accession>
    <name>Q5B322_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycosyltransferase family 25 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ANIA_05058</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 25 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF76181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_662662.1">
        <property type="nucleotide sequence ID" value="XM_657570.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B322"/>
    <dbReference type="STRING" id="227321.Q5B322"/>
    <dbReference type="CAZy" id="GT25">
        <property type="family name" value="Glycosyltransferase Family 25"/>
    </dbReference>
    <dbReference type="GeneID" id="2872847"/>
    <dbReference type="KEGG" id="ani:ANIA_05058"/>
    <dbReference type="eggNOG" id="ENOG502S3CD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_548630_0_0_1"/>
    <dbReference type="InParanoid" id="Q5B322"/>
    <dbReference type="OrthoDB" id="47375at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050757">
        <property type="entry name" value="Collagen_mod_GT25"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10730:SF53">
        <property type="entry name" value="GLYCOSYLTRANSFERASE 25 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10730">
        <property type="entry name" value="PROCOLLAGEN-LYSINE,2-OXOGLUTARATE 5-DIOXYGENASE/GLYCOSYLTRANSFERASE 25 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBF76181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="497" mass="56068" checksum="CC4A0B9E0BB8E9CF" modified="2005-04-26" version="1">MPTRLRLIYLIAGALVLFAFLHLFQGPELSPTSAFLPRDTAGNNTLGFQQIFALSQHPSWRTRGLDAAANLTGLQITIPPQPPVDDRLVEAFANIQGDPWDTQHPSPGASKAWLAHLDLLKHVYQSEIETALILEDDVDWDIALRNQMMNISTAVRNLTRAPETDRSPYSLEWDVLWLGHCGERWDESIETIVFNDTHVCPHEDYRGFWPDEIALLPDLKRTVYRSNSPVCTFAYAVTHKGARRILESLGAGQGEAFDVQLQIECHSQRLTCVSVVPEVFHQYFPPAQFGVKSDVDIGNNKGDGPVEETFESVMGSTENILHSARCRALWGSDSYSVLDLLWSISAISKRSGYDVERRSITIRYWVITLPKKDSSEMPILPTRTTCMMSFELFRPSNLALLFANVFSRPQPQKFVVPACRNENATAVTQYTSGRDGFDAPKVHPINATTYDWWWFDAIQQPVPTEDGGQSQAHIVITFYNLGSEVLTEQFPKRLAEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="122" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B3E6</accession>
    <accession>C8V9D1</accession>
    <name>Q5B3E6_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">3-oxoacyl-(Acyl-carrier-protein) reductase, putative (AFU_orthologue AFUA_3G10540)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ANIA_04934</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF76445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_662538.1">
        <property type="nucleotide sequence ID" value="XM_657446.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B3E6"/>
    <dbReference type="STRING" id="227321.Q5B3E6"/>
    <dbReference type="GeneID" id="2872729"/>
    <dbReference type="KEGG" id="ani:ANIA_04934"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN4934"/>
    <dbReference type="eggNOG" id="KOG1200">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_3_1"/>
    <dbReference type="InParanoid" id="Q5B3E6"/>
    <dbReference type="OMA" id="HGNAGQI"/>
    <dbReference type="OrthoDB" id="1393670at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016857">
        <property type="term" value="F:racemase and epimerase activity, acting on carbohydrates and derivatives"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF133">
        <property type="entry name" value="3-OXOACYL-[ACYL-CARRIER-PROTEIN] REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="5">
        <location>
            <begin position="22"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBF76445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="294" mass="30837" checksum="031FF604F49FDB81" modified="2005-04-26" version="1">MASRLSQLNAHLNYPRGLLADQVAIITGAGQGIGAEAARLFANEGAKVVIADIDGEKANAVANAINSASPNRAIAVVGDILNDKYITTLVEKAAEFGNGKIHIIVNNAGFTWDGVIHKITDKQWDTMIAVHNTAPFKLIRAAAKYFRVKDGEPRVIINISSTSGIHGNAGQANYALAKAGVVGLTRTIAKEWGPQFGVRSNTIAFGFVQTRLTAAKEKGAFITTPDGTKVALGIPGQQLGAKEGAKDGKPAYPDIPLGRPASPEEAARSVLAVASPLFSYVNGETIRVTGGRNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="116" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B3W9</accession>
    <accession>C8VAR1</accession>
    <name>Q5B3W9_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 15">Dolichyl-phosphate-mannose--protein mannosyltransferase</fullName>
            <ecNumber evidence="4 15">2.4.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">ANIA_04761</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="19">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17377"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:13546"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
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        <reaction evidence="13 15">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
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        <text evidence="2 15">Protein modification; protein glycosylation.</text>
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        <subcellularLocation>
            <location evidence="1 15">Endoplasmic reticulum membrane</location>
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        <text evidence="3 15">Belongs to the glycosyltransferase 39 family.</text>
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        <property type="component" value="Chromosome III"/>
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        <property type="term" value="P:protein O-linked glycosylation via mannose"/>
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        <property type="entry name" value="PMT_4TMC"/>
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    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 15 18" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="611"/>
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    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="674"/>
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        <location>
            <begin position="703"/>
            <end position="720"/>
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            <begin position="336"/>
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    <feature type="region of interest" description="Disordered" evidence="16">
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    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="843"/>
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    </feature>
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        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="11"/>
            <end position="20"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="778"/>
            <end position="794"/>
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    </feature>
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            <begin position="795"/>
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            <end position="860"/>
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        <location>
            <begin position="887"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
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            <dbReference type="ARBA" id="ARBA00022676"/>
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        <source>
            <dbReference type="RuleBase" id="RU367007"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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            <dbReference type="EMBL" id="CBF76842.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
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    </evidence>
    <sequence length="918" mass="103441" checksum="A5CE05A4F5E92ED5" modified="2005-04-26" version="1">MAKDTLDVRPPRTSSRSPSRSPRPKNRKKATAVASSYQSDGVTDNNIFDLPMSDYKVMVLVTIVAAVVRLFRIYQPTSVVFDEVHFGGFATKYIKGRFFMDVHPPLAKLLITLAGWLAGFKGDFDFKEIGKDYLEPGVPYVAMRMLPAILGVLTVPIMFLTLKATGCRTNTAVLGAGAILFENGLVTQSRFILLDSPLVFFTALTALSFTCFTNQQELGPSHAFRGPWWFWLVATGFSLGATLSVKWVGLFTVAWVGSLTILQLWVVLGDTNNVTPRLWFKHFFARVFCLIVIPLAFYCSMFAIHFRCLVNPGEGDGFMSSEFQATLNSKGMAAVPADVVFGSRLSIRHHNTQGGYLHSHSHMYPTGSKQQQITLYPHKDDNNLFIAENQTQPLDANGAEIPGPFAWDNLTTNYIEDGAVIRLHHLMTHRRVHSHNERPPVTDVDWQFEVSAYGYEGFPGDANDYWRVEIVKSLSDGEEAKKRLRTIQSKFRLVHVMTGCVLFSHKVKLPDWGFDQQEVTCAKGASLPNSIWYIESNKHPMLPPDAEKVTYRNPGFFGKFFELQKVMWTTNAGLTDSHAWDSRPPSWPTLLRGINFWGRDHRQVYLFGNPFVWYSSTLAVLVYVIFKGISLLRWQRNCGDYRNPAFKRFDYEIGTSVLGWGFHYFPFYLMARQLFLHHYFPALYFAILALAQEFDFITNRIRSLGLTIFAFTVYSPLIYGNPWTRDACKQVKLLKSWDFDCNTFYTDLNQYVTHFSSVNSAVPTTAASIPQSPAPVKAEPKQEQKEQKEAKVESQEPSITSSSIPKIRGTQARVEYRDQQGNILDEAVVDSLRKEGKISIETRHETRTRLEHGHLVDVVDGKVAPPHPDVEGQNPETQDKPEEIVDDSPASAADAGSSVGEPNSPEPKPASEGNEATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B454</accession>
    <accession>C8VB02</accession>
    <name>Q5B454_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Conserved glutamic acid rich protein (AFU_orthologue AFUA_5G09010)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_04676</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF77020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_662280.1">
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    <accession>C8V7P0</accession>
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            <taxon>Eurotiomycetidae</taxon>
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        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
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                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
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                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
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            <dbReference type="DOI" id="10.1038/nature04341"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
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    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
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                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
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            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
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        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
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</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="108" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B4H0</accession>
    <accession>C8V867</accession>
    <name>Q5B4H0_EMENI</name>
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            <fullName evidence="2">Ribosome biogenesis protein RLP24</fullName>
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        <name evidence="6" type="ORF">ANIA_04560</name>
    </gene>
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        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
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            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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        </lineage>
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    <reference evidence="7" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
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                <person name="Freitag M."/>
                <person name="Selker E.U."/>
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                <person name="Penalva M.A."/>
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                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
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            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
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                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL24 family.</text>
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        <property type="protein sequence ID" value="CBF77256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_657072.2"/>
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    <dbReference type="VEuPathDB" id="FungiDB:AN4560"/>
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    <dbReference type="OrthoDB" id="10262490at2759"/>
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        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051117">
        <property type="term" value="F:ATPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902626">
        <property type="term" value="P:assembly of large subunit precursor of preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00472">
        <property type="entry name" value="Ribosomal_L24e_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.170.20:FF:000001">
        <property type="entry name" value="probable ribosome biogenesis protein RLP24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.20">
        <property type="entry name" value="Ribosomal protein L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038630">
        <property type="entry name" value="L24e/L24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056366">
        <property type="entry name" value="Ribosomal_eL24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000988">
        <property type="entry name" value="Ribosomal_eL24-rel_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011017">
        <property type="entry name" value="TRASH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10792">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10792:SF8">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN RLP24-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01246">
        <property type="entry name" value="Ribosomal_L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00746">
        <property type="entry name" value="TRASH"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="TRASH" evidence="5">
        <location>
            <begin position="6"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="147"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="147"/>
            <end position="169"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005647"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBF77256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="190" mass="22217" checksum="0A00111EDD5B500F" modified="2005-04-26" version="1">MRIETCHFCSRPVYPSKGIQMVRLDGKAFRFCRSKCHANFKLKRQPRKLKWTKAGRAASGKEMIVDSSLVLSQFAKKRNVPVKYDRNLVAATVQAMERVEEIRARRERAFTKRRLAGKLARERKREEDRKVVAEGEHLIRKELREREEGRSLAEEGVKVANRVHGEERLRQKKKTRLLVDGTTQDEMDVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B5R8</accession>
    <accession>C8V595</accession>
    <name>Q5B5R8_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Erythromycin esterase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_04112</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF74683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_661716.1">
        <property type="nucleotide sequence ID" value="XM_656624.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B5R8"/>
    <dbReference type="GeneID" id="2873537"/>
    <dbReference type="KEGG" id="ani:ANIA_04112"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN4112"/>
    <dbReference type="eggNOG" id="ENOG502T00Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015328_0_0_1"/>
    <dbReference type="InParanoid" id="Q5B5R8"/>
    <dbReference type="OMA" id="GHASAWR"/>
    <dbReference type="OrthoDB" id="5204833at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="374"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="469"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="295"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="535"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="569"/>
            <end position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF74683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="593" mass="64387" checksum="2A0B4B771C403EB1" modified="2005-04-26" version="1">MAVRRSARLRSRQSPAQDTPAELNQNNSNNDRSENKLDAVMEREEPVESPKPQSTPAKVAHTPKGKLKKSPAKTPVTSLTRPTHFEMHPSKVHQSTTKQADSGLILGFNPIKKDAHGNVVKDDPAQSTPSKTNASPASTFYGTPAFEFKFSAQDTELSDEAKKLMESVREDVARIKANMVNEKANATGDAPQTSERKIAKPKGKAGRFSDVHMAEFKKMDSIAGHASAFRATPGRFQPVQKTLKRTSSKARLDEPESQKSPAATTLKASAPSTPSAKRTKQDRAAVTPQSRLPKSAIARPRSSIRSSLLTPTRASLARQSGSLKPPRTSMIPSLARSPLSKPAEAPNTPRTEFNPRFKSNIPTLSSLKSILRPHQPLFSKDPSKIAAGTHRAAQDFTPDLLLQPSRESSPGAAPTPSPKKRVEFTPCTKTQLAEEVISPSPFKKPATITYPSTYDVVYPTLPVLTPDRNAQKSATIRSVRPSDVPVEATLPEVPGMPHGLSHKKRHRAAEDEPDRENVPPADHSPGRSVKRVKINTPQPSKTQASSPLKSRSQTPSRLGSGAIRKGTPASARSRSRALSMSRLNMLAQPKNRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="121" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B709</accession>
    <accession>C8V3T5</accession>
    <name>Q5B709_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ANIA_03672</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF75642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_661276.1">
        <property type="nucleotide sequence ID" value="XM_656184.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B709"/>
    <dbReference type="GeneID" id="2873093"/>
    <dbReference type="KEGG" id="ani:ANIA_03672"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN3672"/>
    <dbReference type="eggNOG" id="KOG0143">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010119_6_1_1"/>
    <dbReference type="InParanoid" id="Q5B709"/>
    <dbReference type="OMA" id="ARCPAHT"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044283">
        <property type="term" value="P:small molecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.330:FF:000030">
        <property type="entry name" value="Thymine dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="3">
        <location>
            <begin position="180"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBF75642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="335" mass="38323" checksum="D50CEEBD938B4E19" modified="2005-04-26" version="1">MGLPVVDFSSWHNVKDERSRQRVAQQLVDACQRVGFVRIINHSLPEGALDEAFEWMKRLFALPEEDKMKAPHPAGWAVHRGYSWPGLEKVTQIMSTDGDGDVKKKLREVPDVKEVYDIGSEDDTSQPNQWLPNAILPGFRDFMVQFYSECDRVGKEILRAIAVGLDLEDAEYLTRKHSGNSNQLRLLHYLPVPAEDLEKDRVTRCAAHTDWSSITMLFQDDCGGLEVEDISRPGTFVPAQPVKDSIIMNIGDLLQRWSNDRLRSTNHRVSLPTLSDRIGGPDRMTRERFSIPYFMSPDDEVLVECIPSCMNDETPAKYEPITRGDYNKMRMSMMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B838</accession>
    <accession>C8VI09</accession>
    <name>Q5B838_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ANIA_03292</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF83016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_660896.1">
        <property type="nucleotide sequence ID" value="XM_655804.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B838"/>
    <dbReference type="GeneID" id="2873915"/>
    <dbReference type="KEGG" id="ani:ANIA_03292"/>
    <dbReference type="HOGENOM" id="CLU_2158346_0_0_1"/>
    <dbReference type="InParanoid" id="Q5B838"/>
    <dbReference type="OrthoDB" id="4421424at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF83016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="111" mass="12626" checksum="649C05FE036D84B5" modified="2005-04-26" version="1">MYSRVKGGEGDTKYHAQNPDLQLWVAATLARRRRVYHEFAVFGTLLQVPQSKWPRDQKASGRTITARPFIPLMMYLMLILSVDYLPQEAYAGVCGVVVESVLYEERESDGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="103" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B8A9</accession>
    <accession>C8VI85</accession>
    <name>Q5B8A9_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS transporter, putative (AFU_orthologue AFUA_4G01000)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ANIA_03221</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF83157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_660825.1">
        <property type="nucleotide sequence ID" value="XM_655733.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B8A9"/>
    <dbReference type="GeneID" id="2874162"/>
    <dbReference type="KEGG" id="ani:ANIA_03221"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN3221"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_0_1_1"/>
    <dbReference type="InParanoid" id="Q5B8A9"/>
    <dbReference type="OMA" id="NAIVIMF"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000034">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF48">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G01000)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="188"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="292"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="335"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="360"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="386"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="419"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="452"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="62"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBF83157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="510" mass="56742" checksum="93DFEABBF2C4436E" modified="2005-04-26" version="1">MATTSVADEKAMSGHQENLKPVDDPTQFAHRGQAATDQYGHALFEFDKKAESRLRWKMDFYLLPTVALLYLFCFIDRANIGNARLAGFDTDLGLKGNDYNKVLSIFYVSYILFEIPCNLCCKWMGPGYFLPLSTLCFGAASVATAFVDNIQEASGVRFVLGIFEAGMLPGIAYYLSRWYRRSELAFRLALYIVMAPLAGAFGGLLASAILTLDHFGSLHTWRMIFAIEGIVTCALGLIAFLTLTDRPETARWLSQEEKDLAIARLKSERVATTEVLDKIDTKKLLRGIFSPVTLSTSFIFLLNNITVQGLAFFAPTIVRTIYPDASVVSQQLHTVPPYVVGAFFTLLFPFLSWRFDKRMPFFIAGPPLMMIGYIMFLASSDAMTRYGATFLIASGAFAFGALCNAHVSNNVISDTARSAAIGTNVMFGNIGGLVSTWSFLQFDGPDYHIGNGLNLATSSMCLILSALLWMWMKWDNKKRDDTDVDAALDGLTQKQVQDLDWRNPAFKWRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B8G8</accession>
    <accession>C8VIF2</accession>
    <name>Q5B8G8_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_03162</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF83282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_660766.1">
        <property type="nucleotide sequence ID" value="XM_655674.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B8G8"/>
    <dbReference type="GeneID" id="2873854"/>
    <dbReference type="KEGG" id="ani:ANIA_03162"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN3162"/>
    <dbReference type="eggNOG" id="ENOG502SQSW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060131_6_2_1"/>
    <dbReference type="InParanoid" id="Q5B8G8"/>
    <dbReference type="OMA" id="WPNETIQ"/>
    <dbReference type="OrthoDB" id="410198at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF4">
        <property type="entry name" value="ACETYLTRANSFERASE, GNAT FAMILY FAMILY (AFU_ORTHOLOGUE AFUA_4G09540)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="33"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF83282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="225" mass="25575" checksum="89CF6D72A38DF47B" modified="2005-04-26" version="1">MAPTPSPLYTFRQVERSDLDALEELLFTSKLSLTINRLLFKDWPNEAAQRRNYRAALENQDFESDDRERLGVIDNASGKLIGFIALCRRQPELHTQAASPSVDGPEKQMNIPDHFNPEVYNAVMNAVRELSFTGLETREHYEVVYIAVDHAFRRRGIGRDLVRHVFAKAKAAGVPVAVSSEPQAYAFFTEMGFEETKSVEMDLAQWAPSYSGFGAFRLRSMIWNP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-03-03" modified="2025-04-09" version="99" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B8S5</accession>
    <accession>C8VIR8</accession>
    <name>EIF3K_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Eukaryotic translation initiation factor 3 subunit K</fullName>
            <shortName evidence="1">eIF3k</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">eIF-3 p25</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="ORF">AN3055</name>
    </gene>
    <organism>
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF-3 subunit K family.</text>
    </comment>
    <dbReference type="EMBL" id="AACD01000051">
        <property type="protein sequence ID" value="EAA63626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF83491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_660659.1">
        <property type="nucleotide sequence ID" value="XM_655567.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B8S5"/>
    <dbReference type="SMR" id="Q5B8S5"/>
    <dbReference type="STRING" id="227321.Q5B8S5"/>
    <dbReference type="EnsemblFungi" id="CBF83491">
        <property type="protein sequence ID" value="CBF83491"/>
        <property type="gene ID" value="ANIA_03055"/>
    </dbReference>
    <dbReference type="KEGG" id="ani:ANIA_03055"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN3055"/>
    <dbReference type="eggNOG" id="KOG3252">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076723_0_1_1"/>
    <dbReference type="InParanoid" id="Q5B8S5"/>
    <dbReference type="OMA" id="GDDLCAD"/>
    <dbReference type="OrthoDB" id="337745at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006446">
        <property type="term" value="P:regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000389">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.250:FF:000003">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.250">
        <property type="entry name" value="ARM repeat, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03010">
        <property type="entry name" value="eIF3k"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033464">
        <property type="entry name" value="CSN8_PSD8_EIF3K"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009374">
        <property type="entry name" value="eIF3k"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016020">
        <property type="entry name" value="Transl_init_fac_sub12_N_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13022">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13022:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10075">
        <property type="entry name" value="CSN8_PSD8_EIF3K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0396">Initiation factor</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000365059" description="Eukaryotic translation initiation factor 3 subunit K">
        <location>
            <begin position="1"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="PCI" evidence="2">
        <location>
            <begin position="46"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01185"/>
        </source>
    </evidence>
    <sequence length="250" mass="27892" checksum="8A0021F3F31DAB13" modified="2005-04-26" version="1">MGVAIDKCETRPANIEAILSGLDRYNPETTTVFQDYVVQQCEDRTFDCYANLALLKLYQFNPHLLQPETVTNILVKALTVFPSPAFSLCLALLPAYTQPFPSSEAEATAAQMSDFVESVQKLARLSSLLESAQYAQFWSTLNSDDLYADLVADVAGFEELVRIRIAVEVGKAFREVNAEVLEQWLDVRNSEALEKFVTEVCSWEVDKSGSATVVKVPTNKENEARSEVKSERVGVDMFGRVIRRGFEQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="101" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B8W8</accession>
    <accession>C8VIW1</accession>
    <name>Q5B8W8_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ANIA_03012</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex. Involved in pre-tRNA splicing, probably by affecting the interaction of pre-tRNA with splicing endonuclease.</text>
    </comment>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF83568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_660616.1">
        <property type="nucleotide sequence ID" value="XM_655524.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B8W8"/>
    <dbReference type="FunCoup" id="Q5B8W8">
        <property type="interactions" value="758"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5B8W8"/>
    <dbReference type="GeneID" id="2874050"/>
    <dbReference type="KEGG" id="ani:ANIA_03012"/>
    <dbReference type="eggNOG" id="KOG2020">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003712_0_0_1"/>
    <dbReference type="InParanoid" id="Q5B8W8"/>
    <dbReference type="OMA" id="IAKRSWG"/>
    <dbReference type="OrthoDB" id="2215036at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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    <dbReference type="GO" id="GO:0005049">
        <property type="term" value="F:nuclear export signal receptor activity"/>
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    </dbReference>
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        <property type="term" value="F:RNA binding"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="P:RNA export from nucleus"/>
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        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000375">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013598">
        <property type="entry name" value="Exportin-1/Importin-b-like"/>
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    <dbReference type="InterPro" id="IPR045478">
        <property type="entry name" value="Exportin-5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045065">
        <property type="entry name" value="XPO1/5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11223">
        <property type="entry name" value="EXPORTIN 1/5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11223:SF3">
        <property type="entry name" value="EXPORTIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19273">
        <property type="entry name" value="Exportin-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08389">
        <property type="entry name" value="Xpo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Exportin-1/Importin-beta-like" evidence="3">
        <location>
            <begin position="107"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="Exportin-5 C-terminal" evidence="4">
        <location>
            <begin position="330"/>
            <end position="1197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF19273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBF83568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="1250" mass="141015" checksum="9FE3D13FE12BA8AF" modified="2005-04-26" version="1">MAAEEGLVDGGIAGIVRALELIHNPSSTNELRREALQFVESQKQSSSAARNGFMLASRRENDALVRYFGLTLLDHVLRNTSFTATDEITNLRDIVLKLAESIQPEDPTYIRNKIPQLWAEVAKRSWGLDWLDMDQRLVQFWNASLVHKELVLLVLETLSDDIFYREDTVSSLRGTDLNRALVEICTPLAVFEQAYPERDNHVAIRCGNEGWLTRICEFLQQCIGSVQHSKEAKDAALKALANLKSVLVWSIPKAIHLSGCVPSIAGAFTCTDEQVLLAAVEALHALYSRSAYDIEGFQPLVHLMYETESLNVILKLFQWSIVSPEDIDDTKYTISKKLSEMVSYVAGFLEEKGFSIETSAGVDLPFFFHLMLNVVQHRSLTVSIPVLHIWSKLIANPKIGNLDVVINLIPPLLTICTERLVHWESLPADSEDPTVIFLNEDIDTVPEKHAFVGNYRRYCSSIIETIVQKRPEEAIPHILLGVDNNLDNLYSGVEPFTAKSFSKNSVPLMRADTQFAVVEATLKGYTKWVAVHGRMPQQDEQRRGQLENILETWAYKLMQRNFEDPILKQRIVKLVVDISARALDKTPSFALKVLEYTLMTRLPDQPEFPNYSEAVKELHGLASHELRRLATRYADYFSTFYDLLEPKIQEITMANRVDDKLHMEFTSILLIIMQRANNVDPFLRQSRLASFVEPIKQAWQDDEIRSKSSTFEGFCNLLGLQNVGPYMQSKHAQKLADWSEVPLDAEGKQVQEEMTQRFQQLPLRGTKTMMAVSTDKLKKADPPYEIACTLWHDLIPIILPTLLQLVSNAHAFHNPENWAGLPGDMWGIVERILTDRFWQAGISSGSRDEFYAKITASRTSLEGFASSVRGKVRAVRESCYSMLFSMSRLREHFYGFAELPGPLSQALFKDSSHLSSHQFSVLLNISRCIIDDCPVRFRSQFLPPMLSTLFVNIDRKVTSEWESIEQRKAGLGDGDLADEMKSESILRQLTYSAVIMVASLLDPQRGGMQPVQKSAALPIKLTLFYVDPDEEPTDPSAPQPLPALSDSIRHFVLSSTEIFEPVMLFCTHALRMRDTRCCSIITRVIRSILQDFAPPHNSQTVVTIREFISSEVLKACITSVHEPYFVDMQKDLAQLIASIWVLYGSSTPTPKALILSLPGMTEERVASTEAALVRSTSARQQRALVLDLLEGLRGVSIAEQGKILGSREERRKARSALQERYMSNEMEGQQTHKVDINDGPDLSGVADMFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="112" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B9A6</accession>
    <accession>C8VJA9</accession>
    <name>Q5B9A6_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_02874</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF83831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_660478.1">
        <property type="nucleotide sequence ID" value="XM_655386.1"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5B9A6"/>
    <dbReference type="GeneID" id="2873908"/>
    <dbReference type="KEGG" id="ani:ANIA_02874"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN2874"/>
    <dbReference type="eggNOG" id="KOG1426">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_256714_0_0_1"/>
    <dbReference type="InParanoid" id="Q5B9A6"/>
    <dbReference type="OMA" id="QNAWSET"/>
    <dbReference type="OrthoDB" id="4478167at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007346">
        <property type="term" value="P:regulation of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901673">
        <property type="term" value="P:regulation of mitotic spindle assembly"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="904"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="956"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="1116"/>
            <end position="1177"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="1238"/>
            <end position="1312"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="1313"/>
            <end position="1364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="109"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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            <begin position="280"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="327"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="477"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1087"/>
            <end position="1107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="123"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="154"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="190"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="214"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="247"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="284"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="374"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="477"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="489"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="544"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="555"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="570"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
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            <begin position="599"/>
            <end position="609"/>
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        <location>
            <begin position="784"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="815"/>
            <end position="827"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF83831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="1365" mass="145877" checksum="67ED4CFC218EE5BA" modified="2005-04-26" version="1">MAAGNHADGNYDLDSNDPSDTALDWEDKSPTGAAFASAHPPAPRPRLPYFRRPSGPPSQPRLDSSSPPTPDRPRSLLSSPPKVVIAARNPTGGIRGKLSCILNALSSALGLGRNGDGARARDSASVAADSNSALIAAEEAEAEVETADANNNGESDEGKDENPEGNDNEGEREEEYTVSDEAGEQRETENLGTQSTGTAWNFAAPGMGYYTESEVAEELEVDETGIERGTEDDEDEAGEAGEKRASAESNTDGQLPKTTTSHFYSLDIPLLEIEDGEVPIASPSLANPKSSWLSSDGGLRSAGVGLPSPSGSVANCRWSATLPVYTSNPPKQTKHEEYQPLADAASSDCAPISLSNGLDQPLVVPRDDEDGGADEDRGGQEEQEEKVGDRHIRTAGVNGPPEFNMLNSRIPNAFDRFLIEAPGPSIMPLPTVYGLSRPLQDQALQVWGDENEQPLSAQGNDTALLFHDADRLIPSIEVDHDHDHDRPNSSDGLRSDSATARASGPTKPSGRRPGTKRYNGSRSNKGDIAWGKANRGSYSIQEPTTEDTEEDVGEEREKRQDGVTTDRLEGGPGGILGEGYPEGGSSAGGGPDNSLGYSQERDNDRDRFPEMSPDPPTPVEYPESPVVLDFRGQTPEVSPDPPTPREDLEIPISRELTVSPDPPTPVEFPETPILLAFGNHTPEVSPDPPTPKEDPELPVPGNSTISPDPSTPLDSAESRPTAVASTSRWSIAPPPPPTPSRPAVTRPRSRIAYGKFGNLTVPDASLSNSGPRASKRRRKRGQVEDGEYVNEAGEEDDFSDDDRNNYGGGYDAQKRPSRGSGGRKRKSPSSSNALTAQKRVLRNRTIGFSNTEVGAPGLGEKRAASPSDAGTNAKRAKPGTPAASGFNRYASTSLVENSVPSRKCSVYVLGENGNGQLGMGNGTPVQYKQPTKNTQLPDVVQVAAGGEHCIALTHDNKIYTWGDNSHGQLGRLTNSMTAQMPGEVDFSEVNLPDYTIFAQVVATRSACFVLTMFGDVYGWGTFSEIYEDENGEQHCEPLGFRHQCKCQRTPLHIQELQNVKRLAAGSDHVLAQISILIGGNRASSSASKMKGSRVRKRKDTIAAEGSSTGSATKVRDVVRSWGAYKRGQLGRTAANIANCLNPLLCDFPGNSSRALKNPDNVSTIGSGKFHSFVIKESGDFLAWGYNKFAQTAFVPPAASVLRRDLKVDKPSTVASLRGQRVHFPTGGVDFSVALTAGGQCLSWGSFQDGVRSIPDTAMSDEPDFNKVAGRDEGTQIPAIMKVPTFVPGINAHDKGIKMVSAGWTHTIAVTNGGKALGWGSNDHYEIHPDETKHPINDPMEIPMEGLRVVEAAAGRFFTILLVQSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B9Y8</accession>
    <accession>C8VHF8</accession>
    <name>Q5B9Y8_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ANIA_02642</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF84292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_660246.1">
        <property type="nucleotide sequence ID" value="XM_655154.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B9Y8"/>
    <dbReference type="GeneID" id="2874212"/>
    <dbReference type="KEGG" id="ani:ANIA_02642"/>
    <dbReference type="HOGENOM" id="CLU_1845075_0_0_1"/>
    <dbReference type="InParanoid" id="Q5B9Y8"/>
    <dbReference type="OMA" id="IVQHRYY"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF84292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="139" mass="16194" checksum="8442EE8ED1C96674" modified="2005-04-26" version="1">MMRFDRPIVQHRYYGKQSQWQMGETLQHQFIVVGDPHEFDPEKWTCNPKELPKRHPETNISVLLVGAALERFRPSNSRRLIHQHAASLESGAYIAQLRQVHAHCSISAYSDLLNLQWLLLMCRIRCELVTLEGSFAEHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="112" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BA19</accession>
    <accession>C8VKN3</accession>
    <name>Q5BA19_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Geranylgeranyl diphosphate synthase, putative (JCVI)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ANIA_02611</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis; terpenoid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">In the C-terminal section; belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">In the N-terminal section; belongs to the terpene synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF87199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_660215.1">
        <property type="nucleotide sequence ID" value="XM_655123.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BA19"/>
    <dbReference type="STRING" id="227321.Q5BA19"/>
    <dbReference type="GeneID" id="2875326"/>
    <dbReference type="KEGG" id="ani:ANIA_02611"/>
    <dbReference type="eggNOG" id="KOG0777">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014015_10_0_1"/>
    <dbReference type="InParanoid" id="Q5BA19"/>
    <dbReference type="OMA" id="CPGETEY"/>
    <dbReference type="OrthoDB" id="6921389at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004311">
        <property type="term" value="F:geranylgeranyl diphosphate synthase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046165">
        <property type="term" value="P:alcohol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001">
        <property type="entry name" value="GERANYLGERANYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001:SF72">
        <property type="entry name" value="THIJ_PFPI FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_3G01210)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19086">
        <property type="entry name" value="Terpene_syn_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="351"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CBF87199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="645" mass="73411" checksum="AFB192C5E4BBB441" modified="2005-04-26" version="1">MSMENIWRYSQPIDPETVRQTPSFTTLPVRVNTRQDVANAATTRALREWDAALQDGMAARALVSFSDLGNLGAFAYPEAEPEKLHILTYLTDMGMLHDDGYEAMDMDTARTEHRELGLLFDPNKPHQPSFNTRAPRIKKLVSQILLEATAIDRALAMYMFDMYNKGWLAVAGEAKEWHFNSVEEYQAYRRNDFGATALWAMTEFAVGIRLSDADRKLIKTVMEPIEKAVIWTNDYWSFDREYYEASVNGSRLVNLVEVIRRCENLSIDDAKARARELLIDTEQTYIRNKEELYANNPSMSLELKRWVEVVGAIVGGTHYWASSAPRHRTWAHEERNMTKSADELMLEIPEEHASSEESTTPDCFSVSSSSSQQTRETDPSDYESSSNQPLDVPKADNGPGSKQFSQPQRGGIEQNCEKQMESPQLFRGLLITFVGCLPKGFDCSPKRRGQPATHVLFGHSQAINSANYMFIQAVRATRSFHNPEAMDILLEELENLYLGQSWDLQWKYNLTCPSIDDYTNMIDNKTGGMFRLLLRLLQNEAGPGGGYGCDQAPGLSLLLDRLTTQFGRFFQIRDDYMNLRNSSYAQQKGCCEDLDEGKFSYPIVYCAAKYPDFKSPMTENISIKYAQPGLFSTIPDFWQMYGKRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="131" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BA86</accession>
    <accession>C8VPS8</accession>
    <name>Q5BA86_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ANIA_02544</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF87067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_660148.1">
        <property type="nucleotide sequence ID" value="XM_655056.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BA86"/>
    <dbReference type="GeneID" id="2875724"/>
    <dbReference type="KEGG" id="ani:ANIA_02544"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_13_1"/>
    <dbReference type="InParanoid" id="Q5BA86"/>
    <dbReference type="OMA" id="ACSYGMA"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000134">
        <property type="entry name" value="MFS sugar transporter protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF38">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="161"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="230"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="323"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="357"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="388"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="423"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="458"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="485"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="53"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBF87067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="552" mass="60169" checksum="13BBB365A9F49F6D" modified="2005-04-26" version="1">MALSGDARTKGVTLPPAPARWSTQLCIRNPAATTTITMPILPHLTVNTYNLTVVILVAIGTISTAYGLAVIGSTVGQPNFYTFFDLEADTTDPDYKHTTNMIGALNGVNSAGAFMGCILQAWSSDAYGRKTTIRLGAAVLIVGGALCAGAVHMAMFLVGRFVAGLGAGILACSVPIYQAEVSTAETRGAMVCVTGVMYAVGYSLAGWLGYACWFMEATSPAAQFAWRFPLAFQVLFPLCVLVGAPFIPESPRWLLAKGKGVEALSVLQKLHSTNGHSNGDNTKAREEFSLMEKQLELDQSRIVKSRWPALALFSTPANRKRSLIATILMIGNQFLGTFVLTNYGVLIYASLGLTGSIPLLLNACWTSFTLIGNTWTALYIDRFGRRRFLLAGATGCTLCMVFLCALTASFLNTDNTPGLRAAVFFIFFYIFWWCFFVDATQFAYIAEIFPNHLRSQGVALGLGWFYLSSEVTLVAAPVGLDRVGWRFYLVLIVPSVLYVGCIYFLFPETKGRTLEEMGRVFGEEHIYRQEAESDTVTEKGVETQRIEDVSTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BAF3</accession>
    <accession>C8VPA0</accession>
    <name>Q5BAF3_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Plasma membrane channel protein (Aqy1), putative (AFU_orthologue AFUA_4G02970)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ANIA_02477</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF86935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_660081.1">
        <property type="nucleotide sequence ID" value="XM_654989.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BAF3"/>
    <dbReference type="GeneID" id="2874892"/>
    <dbReference type="KEGG" id="ani:ANIA_02477"/>
    <dbReference type="eggNOG" id="KOG2513">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010867_0_0_1"/>
    <dbReference type="InParanoid" id="Q5BAF3"/>
    <dbReference type="OMA" id="YNGPLKT"/>
    <dbReference type="OrthoDB" id="296386at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902476">
        <property type="term" value="P:chloride transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007632">
        <property type="entry name" value="Anoctamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049456">
        <property type="entry name" value="Anoctamin_N_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049452">
        <property type="entry name" value="Anoctamin_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12308">
        <property type="entry name" value="ANOCTAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12308:SF73">
        <property type="entry name" value="ANOCTAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04547">
        <property type="entry name" value="Anoctamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20877">
        <property type="entry name" value="Anoctamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="390"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="424"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="471"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="534"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="672"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="714"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="domain" description="Anoctamin alpha-beta plait" evidence="7">
        <location>
            <begin position="120"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="Anoctamin transmembrane" evidence="6">
        <location>
            <begin position="273"/>
            <end position="752"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBF86935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="841" mass="96463" checksum="06E61FE108915A26" modified="2005-04-26" version="1">MGPSTMSPNCRHTVQIKTTLTEHVPFGRYGVLGSTVQQITILRQAHEGPKLAKLRVQLGRMTTFKVLISFISIAGPLGVGWFFLDSPLSDLLLPKPKLGFDQIIEMASSALSGSHNNFYADYVIQYNYANTEPTKASEELELLLRKLWEVGLQAEVRPGEDSNLLVFVRASRKKSLRRAIYQSRIRDWLHGVRNSEPEDESSAEPQTESERLRIINHMITLPHNVGGAGITPKHGHWKNVLAVFPLHDEEKNREYLADWSKKTFLSEEDLDQIRGKFGESVGFYFAFLQSYFKFLLFPAVFGFSCWLLLGSFSIIYTVVNCLWGVIFIEYWKRQEEDLSCRWQTKGVSVVRSKRREFKPEREVYDQVTGETRGVFPATTRLQRQLLQVPFALVALVALGAIIATCFAIEIFISEVYTGPLKSYLVFIPTILLSALIPTMSGVLVSIATKLNDYENYETQTAYDTALTQKIFVINFITSYFPILLTAFVYIPFASLIVPHLDVFHLTVRPFVSKEKATTAHENFTINPDRLRKQVIYFTVTAQVVGFAMETIVPFLKQRFAREYKEYKKKKYGRVNSGLVSETQKETQHSYDDHEDEVQFLTRVRKEADLDDYNVTDDLREMCIQFGYLALFSPVWPLVPVSFLVNNWVELRSDFFKIIVECKRPTPIRVDTIGPWLDTLGFLSWVGSITSAALVYMFNTSTNGPNGEPSAIKGWALLLTIFFAEHLYLIVRYVVQATIAKFEPHNVRREKTEQYMIRKRYLEATLGARSSDEEEEVTAKDESMELSDLTRKSLEDDTRAWSKHNTVAEERFWMRQKGWRESAQVAASIIESQAKPDMKKQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BAJ9</accession>
    <accession>C8VNZ7</accession>
    <name>Q5BAJ9_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Nuclear pore complex protein An-Nup49 (Eurofung)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ANIA_02431</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF86841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_660035.1">
        <property type="nucleotide sequence ID" value="XM_654943.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BAJ9"/>
    <dbReference type="STRING" id="227321.Q5BAJ9"/>
    <dbReference type="GeneID" id="2874805"/>
    <dbReference type="KEGG" id="ani:ANIA_02431"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN2431"/>
    <dbReference type="eggNOG" id="KOG0845">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027081_1_0_1"/>
    <dbReference type="InParanoid" id="Q5BAJ9"/>
    <dbReference type="OMA" id="KLPTHYH"/>
    <dbReference type="OrthoDB" id="2538017at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008139">
        <property type="term" value="F:nuclear localization sequence binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024882">
        <property type="entry name" value="NUP58/p45/49"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13437">
        <property type="entry name" value="NUCLEOPORIN P58/P45 NUCLEOPORIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13437:SF2">
        <property type="entry name" value="NUCLEOPORIN P58_P45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21121">
        <property type="entry name" value="Nup49_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="6" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="24"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="337"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="24"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="59"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="111"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="161"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBF86841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="473" mass="49376" checksum="89434B6E183FD026" modified="2005-04-26" version="1">MFSSKPATPSTGLSINTNSANSLFGGNTNQSANTPATTSSGGGLFGTAATQSKPAGSLFGNTGMGTTQQTQSSGSSLFSGLGGQQNSTSGSGLFGNTTATTTQQQPGGLFSGTTGTNNQANSSGGLFGNTASGATSQAQSKPTFGLGATSTTNNIFGTNPGAGQQQQQQQQQQAQKPTLSLFGTQNTTSQQPTQQTPAAGSNTVIQGVKVDITNLLPTTKYESCADEVKAELERFDTFIVNQINMCNEVASILPLVASQGSTIPNDVEYVQGKLETMQHALENDASDIDQLRSLVSRDAAEAQVAFRAIDTLKLPLQYQSTGGSGWWSAQDQKVSDSQSLRSTRKSTLALPDDVEGEPSMSTINGVPVNLVEYFSQRSDEMGVVLERYTRNLKEIEDHLHGVESTLERQIHEFTTSRNRDSAGNGAPKTVLNDLAAVLADVETGILGVASRLGAVTEQAQEVVLGAPSGLRQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BAQ3</accession>
    <accession>C8VNN4</accession>
    <name>Q5BAQ3_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_02377</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF86722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_659981.1">
        <property type="nucleotide sequence ID" value="XM_654889.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BAQ3"/>
    <dbReference type="GeneID" id="2875558"/>
    <dbReference type="KEGG" id="ani:ANIA_02377"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN2377"/>
    <dbReference type="eggNOG" id="ENOG502SINU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_359857_0_0_1"/>
    <dbReference type="InParanoid" id="Q5BAQ3"/>
    <dbReference type="OMA" id="CNIAITI"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046497">
        <property type="entry name" value="DUF6590"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058925">
        <property type="entry name" value="zf-C2H2_AcuF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35391">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35391:SF5">
        <property type="entry name" value="DUF6590 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20233">
        <property type="entry name" value="DUF6590"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26082">
        <property type="entry name" value="zf-C2H2_AcuF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidoreductase acuF-like C2H2 type zinc-finger" evidence="2">
        <location>
            <begin position="281"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6590" evidence="1">
        <location>
            <begin position="526"/>
            <end position="653"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF86722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="685" mass="77399" checksum="EEBAAC1A9E07D300" modified="2005-04-26" version="1">MNTNHLRRFLNEAQRFDIWASNLGVFHDGHSSLDYRFRDSSPLFEYTSNLLYDLSEALSAFALQVAPGPHSQEAIVDDFDDLTLSDDESEDFSSYQEGSLPDQYLTNISTTVNRLYALSFRVRNPKMRTGLSKALSYKEVDSETGVDLMEAYMERDSRRLEELFRTWRVGDEAGPQFMVERLARANMNRRKQFRYWERRKIKYQYYHNVATGCRWLRELETTSIQRNTRPSEPSTATSPNTSVILETESTVSTDTFVVTSGGTFDPLELPAPPVVDADSPEFECPYCFTICAEETARPHAWRRHILRDLRPYICTFKNCKDADQQYDTFTDWASHESSSHGIQPTATRTCPICTRADSTAHHIASHLRHIACFVFSGNTKATNTDQDAAGHSNSANIGSIDWDSGSEDSDFDDEWAAHTKTIHLDLTACGFGVTRIQLRPEDVVETTVFKYTDPNGHPIPLDYDSLYNDIIVHVDFVRDATISGTPATVDMLGVWIPCEPSITQCSHLEPQDNRARDDPVPPQPAIFAILWHESPSYGSAARSSVLERGPQYIGRFGEPIYSTIRRMVVFRKIEQVSWCFAITTYGGRGLKKSGLNPSQHVVLYERGTTPIIRTDEPPMTMGPLPVVLAAETGRLDSMSRLNFGKIYTVEHNACSSPDILFFWGAEQRNIVAGLCNPQTLKFTLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BB52</accession>
    <accession>C8VMR9</accession>
    <name>Q5BB52_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_02228</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF86424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_659832.1">
        <property type="nucleotide sequence ID" value="XM_654740.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BB52"/>
    <dbReference type="GeneID" id="2874620"/>
    <dbReference type="KEGG" id="ani:ANIA_02228"/>
    <dbReference type="eggNOG" id="ENOG502RPQE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_639393_0_0_1"/>
    <dbReference type="InParanoid" id="Q5BB52"/>
    <dbReference type="OMA" id="TCSDMTF"/>
    <dbReference type="OrthoDB" id="4188313at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="338"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="370"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF86424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="429" mass="46615" checksum="18650467A701D107" modified="2005-04-26" version="1">MDVLLSRTAPKRRASLSLIFGSQKPTFAAALDEKPTRYYDFVDTPSPPKRPSPFISRQEISPELESKIRFSCSLLAYQIEQGIPSLANNQGDRDAAQDEQGESITTEAQLALKAPISNPRPKTASATGYDSGVGLTQQPSIQTMRVQHSQSGDASDTGDTRDISIFSNPRTSTSCSNTSTEPSYPQSSTQSPRTNEPKSTTGAMITGYRQPKWTRTTKAFLSESPSSPIPSGSAPGKEDIEDTKLFLNPTSTITNLSSETLTLSSHPSPSLGLTRVSAATQHQKPTFTSYAHANSNLRKSRSIIIDTAGIAHLLTPDEEAQRNKALQHAVLSKMTPGIMRYNPTQEPSRQQNKQRSTSDGYICKTHHGNEGNSPSQKSRSGSRVGVSWTGIKAALHPSRWKGTDTGSRRLKNQVPLVKNLSRLFGKGSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="100" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BBM9</accession>
    <accession>C8VLM7</accession>
    <name>Q5BBM9_EMENI</name>
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        <recommendedName>
            <fullName evidence="5">Hsp90 chaperone protein kinase-targeting subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ANIA_02051</name>
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    <organism evidence="11 12">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CDC37 family.</text>
    </comment>
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        <property type="protein sequence ID" value="CBF86082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_659655.1">
        <property type="nucleotide sequence ID" value="XM_654563.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BBM9"/>
    <dbReference type="FunCoup" id="Q5BBM9">
        <property type="interactions" value="426"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5BBM9"/>
    <dbReference type="GeneID" id="2874839"/>
    <dbReference type="KEGG" id="ani:ANIA_02051"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN2051"/>
    <dbReference type="eggNOG" id="KOG2260">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033261_0_0_1"/>
    <dbReference type="InParanoid" id="Q5BBM9"/>
    <dbReference type="OMA" id="NYSKWDQ"/>
    <dbReference type="OrthoDB" id="440202at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Cdc37, Hsp90 binding domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Cdc37"/>
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        <property type="entry name" value="Cdc37_Hsp90-bd_sf"/>
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        <property type="entry name" value="Cdc37_N_dom"/>
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        <property type="entry name" value="CDC37-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12800:SF4">
        <property type="entry name" value="HSP90 CO-CHAPERONE CDC37"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CDC37_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08565">
        <property type="entry name" value="CDC37_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03234">
        <property type="entry name" value="CDC37_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CDC37_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01070">
        <property type="entry name" value="CDC37_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01071">
        <property type="entry name" value="CDC37_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101391">
        <property type="entry name" value="Hsp90 co-chaperone CDC37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cdc37 N-terminal" evidence="10">
        <location>
            <begin position="2"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="Cdc37 Hsp90 binding" evidence="9">
        <location>
            <begin position="197"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="Cdc37 C-terminal" evidence="8">
        <location>
            <begin position="381"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="96"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="191"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="465"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="151"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="465"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CBF86082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="489" mass="54774" checksum="5634D40E4923DA3E" modified="2005-04-26" version="1">MVLDYSKWDALELSDDSDIEVHPNVDKRSFIRAKQAQIHQQREQRRLNIKTLKYERIINDGLLSRIEKLLTSFKEKEGSSSNPEEVIFSTLMELASNPEDDQPPSPPEGVHTQEREQPKYSQMMSSLVDQVKAEVEESKHDNVFEAYVKGVQGHKDKVQELQKELLTKLAELEKEEGSKITSESIHTGFDTSHVSKAKAKDKVPASERATSVELLNPKAATEPSNQESNDNEAVDDPDSIQASALAKKFAKIDRNDYRALHQFISDHPEIVAEKETDGLLVEAFNSQMEGKETYARQCVHQGLLLQYCRSLGPDGISLFFKRITTREHQAGTLFRNDVNETYNKIKTRAAELAKDSSASNDPAGVEQIQLHAVDPNTKITINIPRSESNEPVEIEARKIFESFSKELQTALESESLDEVNKVLGKMSVEEAEDVVEKLGESGMLSLEEGIVDATTEEGRKKLEEIEAEGKKGRQLEKVGEPGGTVTELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="121" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BDI3</accession>
    <accession>C8VRM4</accession>
    <name>Q5BDI3_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ANIA_01397</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Aromatic compound metabolism; phenylacetate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF87578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_659001.1">
        <property type="nucleotide sequence ID" value="XM_653909.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BDI3"/>
    <dbReference type="STRING" id="227321.Q5BDI3"/>
    <dbReference type="GeneID" id="2877173"/>
    <dbReference type="KEGG" id="ani:ANIA_01397"/>
    <dbReference type="eggNOG" id="KOG0156">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_2_4_1"/>
    <dbReference type="InParanoid" id="Q5BDI3"/>
    <dbReference type="OMA" id="GPQEAME"/>
    <dbReference type="OrthoDB" id="1055148at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11066">
        <property type="entry name" value="CYP_PhacA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000072">
        <property type="entry name" value="3-hydroxyphenylacetate 6 hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF9">
        <property type="entry name" value="P450, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0349">Heme</keyword>
    <keyword evidence="5 9" id="KW-0408">Iron</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="449"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00060591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBF87578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="517" mass="58334" checksum="6875E33062AFF908" modified="2005-04-26" version="1">MAIAEALLFVNNRAVEHPLQFLTAVAFAVPLLYVVINEFIRASARIPGFKGPRGLPLIGNLAQIRKDAAEQYRIWSKIYGPVYQIQLGNIPVLVVNSAAAAKVLFGQNAQALSSRPEFYTFHKIVSNTAGTTIGTSPYSESLKRRRKGAASALNRPSVESYVHHLDVESKAFVAELFKYGNGGKTPVDPMAMIQRLSLSLALTLNWGVRVASQEEELFDEITEVEDKISKFRSTTGNLQDYIPILRLNPFSSNSHKAKEMRDRRDKYLSSLNRDLDDRMEKGTHKPCIQANVILDKEAKLNSEELTSISLTMLSGGLDTVTTLVAWSISLLAQRPDIQDKAAKAIQEMYSEGQPLCDPADDQKCAYVAALVRECLRYYTVLRLALPRTSIRDITYDGKVIPKGTVFFLNAWACNMDPEVWSDPDEFRPERWFEQPDAPMFTYGMGYRMCAGSLLANRELYLVFIRTLNSFRIEPTEEKIEWHPLKGNSDPTSLVAIPKKYKVRFDLISELIREYDTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="118" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BEH4</accession>
    <accession>C8VTV0</accession>
    <name>Q5BEH4_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WD repeat protein (AFU_orthologue AFUA_1G12380)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ANIA_01056</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
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        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
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        <property type="entry name" value="F-BOX AND WD REPEAT DOMAIN CONTAINING 7"/>
        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="WD_REPEATS_1"/>
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        <property type="entry name" value="WD_REPEATS_REGION"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
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        <location>
            <begin position="77"/>
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    </feature>
    <feature type="repeat" description="WD" evidence="3">
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            <begin position="119"/>
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            <begin position="257"/>
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    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="340"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="358"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBF88241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="373" mass="41409" checksum="8CE87FEB5A67455D" modified="2005-04-26" version="1">MAVSSHRDDFFQTTSALDEQRRKEAKSINTNGSPIRLQSKILAVKPDPFDLGSVFVAQSGGTVRKIVLATGETASIFKGPTAPITSLCFSPNGRILFAGCWDKTIWSWDVNSTQRKLQYEGHTDFVRSVVTTRVNGQDLLVSGGADAQILVFDISSGQRLHVWKGHAKGVQDLLIDPLTLDDNSTEQIVFSAGSDREIRQFDLSKGSQDLTGTEALLAHDTNVYKLHFDQDGDLWTASADKTTKCLIREDGWKANLTLTHPDYVKDVVVDERGGWVITACRDEEIRVWNRSTGQLYHTFSGHYEEVTGLVLLGTMLVSVSIDATIRQWSLKPDDLRNAVAQATEHPTDEPSTNPESMLTEEEERELAELLEDD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2016-06-08" modified="2025-04-09" version="105" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BEJ8</accession>
    <accession>C8VTY1</accession>
    <name>AFOC_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Probable esterase afoC</fullName>
            <ecNumber evidence="5">3.1.2.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Asperfuranone biosynthesis protein B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">afoC</name>
        <name type="ORF">AN1032</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2009" name="J. Am. Chem. Soc." volume="131" first="2965" last="2970">
            <title>A gene cluster containing two fungal polyketide synthases encodes the biosynthetic pathway for a polyketide, asperfuranone, in Aspergillus nidulans.</title>
            <authorList>
                <person name="Chiang Y.M."/>
                <person name="Szewczyk E."/>
                <person name="Davidson A.D."/>
                <person name="Keller N."/>
                <person name="Oakley B.R."/>
                <person name="Wang C.C."/>
            </authorList>
            <dbReference type="PubMed" id="19199437"/>
            <dbReference type="DOI" id="10.1021/ja8088185"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2010" name="Basic Clin. Pharmacol. Toxicol." volume="107" first="583" last="589">
            <title>Asperfuranone from Aspergillus nidulans inhibits proliferation of human non-small cell lung cancer A549 cells via blocking cell cycle progression and inducing apoptosis.</title>
            <authorList>
                <person name="Wang C.C."/>
                <person name="Chiang Y.M."/>
                <person name="Praseuth M.B."/>
                <person name="Kuo P.L."/>
                <person name="Liang H.L."/>
                <person name="Hsu Y.L."/>
            </authorList>
            <dbReference type="PubMed" id="20148857"/>
            <dbReference type="DOI" id="10.1111/j.1742-7843.2010.00545.x"/>
        </citation>
        <scope>BIOTECHNOLOGY</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Probable esterase; part of the gene cluster that mediates the biosynthesis of asperfuranone, a probable antitumor agent (PubMed:19199437). The polyketide synthase afoG is responsible for producing the 3,5-dimethyloctadienone moiety from acetyl-CoA, three malonyl-CoA, and two S-adenosyl methionines (SAM) (PubMed:19199437). The 3,5-dimethyloctadienone moiety is then loaded onto the SAT domain of afoE and extended with four malonyl-CoA and one SAM, which leads to the formation of 2,4-dihydroxy-6-(5,7-dimethyl-2-oxo-trans-3-trans-5-nonadienyl)-3-methylbenzaldehyde (compound 2) after reductive release and aldol condensation (PubMed:19199437). AfoD is the next enzyme in the biosynthesis sequence and hydroxylates the side chain at the benzylic position of compound 2 (PubMed:19199437). After benzylic hydroxylation, a furan ring is formed after five-member ring hemiacetal formation and water elimination (PubMed:19199437). AfoF and afoC are proposed to oxidize the R-diketone proton and to reduce the unconjugated carbonyl group, respectively, to generate asperfuranone (PubMed:19199437). Since no intermediates could be isolated from afoF and afoC deletants, the sequence of these two enzymes is not fully understood (PubMed:19199437). Moreover, since afoC deletant still produces a small amount of asperfuranone, other endogenous oxidoreductases might catalyze the same reaction with much less efficiency (PubMed:19199437).</text>
    </comment>
    <comment type="induction">
        <text evidence="3">Expression is regulated by the asperfuranone cluster transcription factor afoA (PubMed:19199437).</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="3">Strongly diminishes production of asperfuranone (PubMed:19199437).</text>
    </comment>
    <comment type="biotechnology">
        <text evidence="4">Asperfuranone provides anti-proliferative activity in human non-small cell lung cancer cells (PubMed:20148857).</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the LovG family.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.-" evidence="5"/>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF88298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AACD01000015">
        <property type="protein sequence ID" value="EAA65600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_658636.1">
        <property type="nucleotide sequence ID" value="XM_653544.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BEJ8"/>
    <dbReference type="SMR" id="Q5BEJ8"/>
    <dbReference type="STRING" id="227321.Q5BEJ8"/>
    <dbReference type="ESTHER" id="emeni-afoc">
        <property type="family name" value="FSH1"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CBF88298">
        <property type="protein sequence ID" value="CBF88298"/>
        <property type="gene ID" value="ANIA_01032"/>
    </dbReference>
    <dbReference type="KEGG" id="ani:ANIA_01032"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN1032"/>
    <dbReference type="eggNOG" id="KOG2551">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051938_0_0_1"/>
    <dbReference type="InParanoid" id="Q5BEJ8"/>
    <dbReference type="OMA" id="DAPFFCD"/>
    <dbReference type="OrthoDB" id="414698at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900554">
        <property type="term" value="P:asperfuranone biosynthetic process"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000296">
        <property type="entry name" value="Probable esterase afoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005645">
        <property type="entry name" value="FSH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050593">
        <property type="entry name" value="LovG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070:SF3">
        <property type="entry name" value="ESTERASE DBAE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070">
        <property type="entry name" value="ESTERASE OVCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03959">
        <property type="entry name" value="FSH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000436371" description="Probable esterase afoC">
        <location>
            <begin position="1"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="204"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="1">
        <location>
            <position position="136"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="1">
        <location>
            <position position="240"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="1">
        <location>
            <position position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P38777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="19199437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="20148857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="5">
        <source>
            <dbReference type="PubMed" id="19199437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="6"/>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAA65600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005890"/>
        </source>
    </evidence>
    <sequence length="297" mass="31685" checksum="128DBD8A963904DC" modified="2005-04-26" version="1">MPALDIASAPAAVYQQQLHLPRILCLHGGGTNARIFTAQCRALRRQLTDSYRLVFADAPFLSSAGPDVTSVYGEWGPFRSWVPVPAGVDISAWAAAGAASRIDIDVEAIDECIAAAIAQDDRAGATGDWVGLLGFSQGARVAASLLYRQQKQQRMGLTSWSRGRDRKRGATSSTNYRFAVLFAGRGPLLDLGFGSGSLAGSSAASSSASASVSGSESAGEEEEDGHLLSIPTIHVHGLRDPGLEMHRDLVRSCRPSSVRIVEWEGAHRMPITTKDVGAVVAELRHLAISRKYESLRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="102" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BFS6</accession>
    <accession>C8VSA3</accession>
    <name>Q5BFS6_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Endonuclease (Eurofung)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ANIA_00604</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF89145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_658208.1">
        <property type="nucleotide sequence ID" value="XM_653116.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BFS6"/>
    <dbReference type="STRING" id="227321.Q5BFS6"/>
    <dbReference type="GeneID" id="2876381"/>
    <dbReference type="KEGG" id="ani:ANIA_00604"/>
    <dbReference type="eggNOG" id="ENOG502QTMI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017168_1_1_1"/>
    <dbReference type="InParanoid" id="Q5BFS6"/>
    <dbReference type="OMA" id="MEEWLKP"/>
    <dbReference type="OrthoDB" id="541883at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033892">
        <property type="term" value="F:deoxyribonuclease (pyrimidine dimer) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000404">
        <property type="term" value="F:heteroduplex DNA loop binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043504">
        <property type="term" value="P:mitochondrial DNA repair"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006290">
        <property type="term" value="P:pyrimidine dimer repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070914">
        <property type="term" value="P:UV-damage excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.150:FF:000012">
        <property type="entry name" value="Related to UV-endonuclease UVE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.150">
        <property type="entry name" value="Divalent-metal-dependent TIM barrel enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004601">
        <property type="entry name" value="UvdE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00629">
        <property type="entry name" value="uvde"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31290">
        <property type="entry name" value="UV-DAMAGE ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31290:SF5">
        <property type="entry name" value="UV-DAMAGE ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03851">
        <property type="entry name" value="UvdE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="Xylose isomerase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0228">DNA excision</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2 8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="425"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="487"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="41"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="487"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="531"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="544"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBF89145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="591" mass="66784" checksum="084E5C3D0A8C518A" modified="2005-04-26" version="1">MAATPAPDTPVKTENEQLESSLGGGDLGDTNGKLDVAPIDPESDEDVPVEAEELQEALSRPPPVNSNYLPLPWKGRLGYACLNTYLRYSNPPVFCSRTCRIASILENRHPLSDPSQPPHATKNRPDRSQPADIARGQAYVEALGLANARDLLKLIRWNDRYGIKFMRISSEMFPFASHKEYGYKLAPFASETLGEVGRLVAELGHRVTVHPGQFTQLGSPRKEVLENSFRDLEYHSEMLQLLKLPAQQDRDAVMILHMGGVFGDKEATLDRFRQNYQKLSQDIKNRLVLENDDVSWSVHDLLPICEELNIPLVLDYHHHNIIFDSSQLREGTLDIMNLYDRIKATWTRKNITQKMHYSEPVSAAITNRQRRKHSDRVRVLPPCDPTMDLMIEAKDKEQAVFELMRTYKLPGHDLFNNILPYVRTDENKPFKPPRKSKKKNGDFVDLEAQVPPPKTVPEEEVGMGGPERRVYWPPGMEEWLRPKKIVRTKALKTPKSNKKAPPREPDGELDAALVTPSTPTKTTKAAERSPSVKKRTSRKRKASSPDPSTPSASDIELSDDAKPPQSQAKSDGVRRSRRTKTVNYAEDSESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="104" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BFW7</accession>
    <accession>C8VSK3</accession>
    <name>Q5BFW7_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_00563</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF89226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_658167.1">
        <property type="nucleotide sequence ID" value="XM_653075.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BFW7"/>
    <dbReference type="STRING" id="227321.Q5BFW7"/>
    <dbReference type="ESTHER" id="emeni-q5bfw7">
        <property type="family name" value="Hormone-sensitive_lipase_like"/>
    </dbReference>
    <dbReference type="GeneID" id="2876344"/>
    <dbReference type="KEGG" id="ani:ANIA_00563"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN0563"/>
    <dbReference type="eggNOG" id="KOG1515">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012494_3_0_1"/>
    <dbReference type="InParanoid" id="Q5BFW7"/>
    <dbReference type="OMA" id="QKNIAYE"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050466">
        <property type="entry name" value="Carboxylest/Gibb_receptor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23024:SF242">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23024">
        <property type="entry name" value="ARYLACETAMIDE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="103"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF89226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="384" mass="41884" checksum="B3EE78E53E053053" modified="2005-04-26" version="1">MAILSTLRRKTRLSSLTLLVKLLRAIIVSVVRFTIKTKPDPDLIEYIPSITISPSKKSETTITAPSPTHNIKVHIYNPPPAQSQPQPTTDKSNPSPVLITACGSGFIIPGLGLDTSYCRLISSKTFHTVIDVGYRLAPEHPFPCAIEDLVSVVHWVRSQPSRFDLNRISIGGFSAGGNLAASVAVNSFPPGTFWGLVLFYPVLDACTPPEMKVAPSEYGSEAGEDGNRGSGNGKKKPPLGGMGSVPTFMMNIMEKCYLVNVFAGAEPKEGSKSELELESDPNATGRNGEDVLKNPRISPAYADANRFPMRCLFVTAEYDCLAKEAEELAERIRVDGVGEERRKVIVHQVQGCGHQFDKNCRPGSERAEIRDEVYGMVVDLLRKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BGJ6</accession>
    <accession>C8VU06</accession>
    <name>Q5BGJ6_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_00334</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF89702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_657938.1">
        <property type="nucleotide sequence ID" value="XM_652846.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BGJ6"/>
    <dbReference type="GeneID" id="2876110"/>
    <dbReference type="KEGG" id="ani:ANIA_00334"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN0334"/>
    <dbReference type="HOGENOM" id="CLU_056022_0_0_1"/>
    <dbReference type="InParanoid" id="Q5BGJ6"/>
    <dbReference type="OMA" id="FWIRISA"/>
    <dbReference type="OrthoDB" id="4414363at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF89702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="395" mass="45623" checksum="6F54EB5A14B601A3" modified="2005-04-26" version="1">MNKDSHRWADEHIRRRPRRTGTSMDQGITVFRKNESDLQRQTEAAVNKKPKRGPLNTIEQAALIKVCEKRARYDEVCNITSSQFWFGIEMALEREIGRRYSHYSCRKRINDYITNRAIYQNDIKNGIKPDPVLLPDPEIRKLLDRWEEMDKYKEQLEREKALGQLVGREPEVPTKNKLQRVADWVRSLPDPEPQARPLVTPPSTNSSQSPVKQDESTVLWARYRKIEDYRAIARSNQLRALNNDLTSSRQLLSNIKEQLHSTLYDPPANQTTTGLKRTREDEVSPDRAAPRPRIELAELEAMVKPPLKQSPGNSNVLTQSEIAPAQMPIETVFSKFWESMLPYFKERALKDGISLIKSESIMHDLFKEVGAAMTKAFMKLEQQTSRSPSAYKPPI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-09-27" modified="2026-01-28" version="121" xmlns="https://uniprot.org/uniprot">
    <accession>Q96UL8</accession>
    <accession>C8VKU0</accession>
    <accession>Q5BC12</accession>
    <name>PCKA_EMENI</name>
    <protein>
        <recommendedName>
            <fullName>Phosphoenolpyruvate carboxykinase (ATP)</fullName>
            <ecNumber>4.1.1.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">acuF</name>
        <name type="ORF">AN1918</name>
    </gene>
    <organism>
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="J. Bacteriol." volume="184" first="183" last="190">
            <title>Regulation of the acuF gene, encoding phosphoenolpyruvate carboxykinase in the filamentous fungus Aspergillus nidulans.</title>
            <authorList>
                <person name="Hynes M.J."/>
                <person name="Draht O.W."/>
                <person name="Davis M.A."/>
            </authorList>
            <dbReference type="PubMed" id="11741859"/>
            <dbReference type="DOI" id="10.1128/JB.184.1.183-190.2002"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction>
            <text>oxaloacetate + ATP = phosphoenolpyruvate + ADP + CO2</text>
            <dbReference type="Rhea" id="RHEA:18617"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.1.1.49"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text>Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.</text>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="AAL10705" version="1"/>
        </conflict>
        <text>Truncated N-terminus.</text>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="EAA65083" version="1"/>
        </conflict>
        <text>Truncated N-terminus.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.49"/>
    <dbReference type="EMBL" id="AY049067">
        <property type="protein sequence ID" value="AAL10705.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AACD01000029">
        <property type="protein sequence ID" value="EAA65083.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF85824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q96UL8"/>
    <dbReference type="SMR" id="Q96UL8"/>
    <dbReference type="FunCoup" id="Q96UL8">
        <property type="interactions" value="241"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q96UL8"/>
    <dbReference type="EnsemblFungi" id="CBF85824">
        <property type="protein sequence ID" value="CBF85824"/>
        <property type="gene ID" value="ANIA_01918"/>
    </dbReference>
    <dbReference type="GeneID" id="2875509"/>
    <dbReference type="KEGG" id="ani:ANIA_01918"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN1918"/>
    <dbReference type="eggNOG" id="ENOG502QQI5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018247_2_0_1"/>
    <dbReference type="InParanoid" id="Q96UL8"/>
    <dbReference type="OMA" id="MRYAGEM"/>
    <dbReference type="OrthoDB" id="184182at2759"/>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004612">
        <property type="term" value="F:phosphoenolpyruvate carboxykinase (ATP) activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006083">
        <property type="term" value="P:acetate metabolic process"/>
        <property type="evidence" value="ECO:0000270"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015976">
        <property type="term" value="P:carbon utilization"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00484">
        <property type="entry name" value="PEPCK_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.8.10:FF:000001">
        <property type="entry name" value="Phosphoenolpyruvate carboxykinase (ATP)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.449.10:FF:000002">
        <property type="entry name" value="Phosphoenolpyruvate carboxykinase [ATP]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.449.10">
        <property type="entry name" value="Phosphoenolpyruvate Carboxykinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.8.10">
        <property type="entry name" value="Phosphoenolpyruvate Carboxykinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00453">
        <property type="entry name" value="PEPCK_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001272">
        <property type="entry name" value="PEP_carboxykinase_ATP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013035">
        <property type="entry name" value="PEP_carboxykinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008210">
        <property type="entry name" value="PEP_carboxykinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015994">
        <property type="entry name" value="PEPCK_ATP_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00224">
        <property type="entry name" value="pckA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006820">
        <property type="entry name" value="PRK09344.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006821">
        <property type="entry name" value="PRK09344.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30031:SF0">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYKINASE (ATP)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30031">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYKINASE ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01293">
        <property type="entry name" value="PEPCK_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006294">
        <property type="entry name" value="PEP_crbxkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68923">
        <property type="entry name" value="PEP carboxykinase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53795">
        <property type="entry name" value="PEP carboxykinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00532">
        <property type="entry name" value="PEPCK_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0210">Decarboxylase</keyword>
    <keyword id="KW-0312">Gluconeogenesis</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000203872" description="Phosphoenolpyruvate carboxykinase (ATP)">
        <location>
            <begin position="1"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="302"/>
            <end position="309"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; AAL10705." evidence="2" ref="1">
        <original>A</original>
        <variation>V</variation>
        <location>
            <position position="196"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; AAL10705." evidence="2" ref="1">
        <original>M</original>
        <variation>I</variation>
        <location>
            <position position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="600" mass="66430" checksum="671518BB53A82C9C" modified="2011-10-19" version="3">MAPGANIHIPPAGPPEPGPLYSDFYQQQIERQRNNNYHSTSLRNMVATSVNRTALHPGGVQPGKGHTELEEELHEHAHIDYDRVAIIANPSVAALYEDALVYETGTAITSSGALTAYSGAKTGRSPSDKRIVKEESSEKEVWWGPVNKPMTPDVWRINRERAVDYLNTRNRIYVIDGFAGWDERYRISVRVVCARAYHALFMRNMLIRPSAEELKHFHPDYVIYNAGSFPANRFTEGMTSATSVAINFAEKEMVILGTEYAGEMKKGVFTILFYEMPVKHNVLTLHSSANEGQNGDVTVFFGLSGTGKTTLSADPKRALIGDDEHCWTDRGVFNIEGGCYAKCIGLSAEKEPDIFNAIRFGSVLENVVFDPISRVVDYDDSTLTENTRCAYPIEYIENAKVPCLSDSHPSNIILLTCDARGVLPPISKLTTEQTMFHFISGYTSKMAGTEDGVTEPQATFSSCFAQPFLALHPMRYARMLADKISQHKANAWLLNTGWVGAGATTGGKRCPLKYTRAILDAIHSGELAKAEYETYDVFNLHVPKSCPGVPDELLNPKNSWTATTSFSDEVNKLAKLFNENFQKYADQATKEVIAAGPVVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>C8V2K4</accession>
    <name>C8V2K4_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RTA1 domain protein, putative (AFU_orthologue AFUA_6G09550)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ANIA_10770</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
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        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
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                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
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                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
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                <person name="Cornell M.J."/>
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            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
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    </evidence>
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        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
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                <person name="Asai K."/>
                <person name="Machida M."/>
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                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
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            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
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                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
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        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
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        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
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                <person name="Tanaka T."/>
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                <person name="Asai K."/>
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                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
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            <dbReference type="DOI" id="10.1038/nature04341"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="27">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="27" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="27">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22 28">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="29">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF74296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467305.1">
        <property type="nucleotide sequence ID" value="XM_050611260.1"/>
    </dbReference>
    <dbReference type="GeneID" id="2873709"/>
    <dbReference type="KEGG" id="ani:ANIA_04289"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN4289"/>
    <dbReference type="eggNOG" id="KOG0017">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001650_18_4_1"/>
    <dbReference type="InParanoid" id="C8V3R7"/>
    <dbReference type="OMA" id="QIHKQAR"/>
    <dbReference type="OrthoDB" id="4501190at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0229">DNA integration</keyword>
    <keyword evidence="20" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="19" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="17" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="16" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="17" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <keyword evidence="3" id="KW-1188">Viral release from host cell</keyword>
    <keyword evidence="18" id="KW-0917">Virion maturation</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="25">
        <location>
            <begin position="546"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="851"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="1440"/>
            <end position="1460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="24">
        <location>
            <begin position="890"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="24">
        <location>
            <begin position="913"/>
            <end position="924"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="CBF74296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="1460" mass="165765" checksum="2CAA886AF6C9AB6C" modified="2009-11-03" version="1">MLDRHSAAKVSVILRTRDDWQSWIEDIKSVALLSKVWGYVDPSKQEDELEEIPIEPEIPADDATSAEIKIFEIKYNQYQRIDRGIAAISEAIHNSLSAPLKHFYINNRESPYKVLRALKKQFAPKDQELQMMAIRRYQKARSMPIKQSNPEAWLTEFESAYYGMKQHDLPEAQDMYVIRDFLGAVMKASKEWAMIRRNLLHQSEYKSQTIADTIAAYREYLSDEMLYQDTKLDVAFAASPTLQGAGISNQTNRTNRVPYYMCGQKHFFRECPYVVISIRKPDFMEEPEIRKKFDDILKIPGAKCNMLKKAMELNKQTTVQNKETTVQHAMAAIMVGFSASEYSMLKESFILDSGATVHICNDKTRFKKLKQEPAGYLRAGNAVVPIEGTGVGDISPNCRGTSNVMISLQETAYVPGFHTNIISASRMKRAGFIWDFAEDRVVKNGHEVCRLAEYQGLWVVEQNGGNRAYAPANENAHAVRPKTSIKHSSKPLILAGNTDIWHKQFGHLNHEAIRHLPNAVKGIQIDDVEPPRSCETCKYSSAPRQISRRPANRATQAFERVHFDLIEFNKAWNGDRWCTHFYDEFTHMHFVYTHGKKNGCVDAAIHLVALIECQFGTKMKFYKSDNEQTLGGAFRTFTDLEGIIHEVSVVATPEQNGFAERSGGVLTSRARHMMIKARLPLDMWPVSMKAAAYILNRTLIRMLGWITPFEKATGKRPNMASLYTFGCRAYVRDQSLNQQNKTLKSKPRRLGGYLVGYKASNIWLIWIPSKQRIEAARDVIFDESSLYDPEQPNDDWEPLATDIDEIDDVQPNTDGETTYEGVDDCQNKVVSRDLNAVSDSPENAGREIVQSEAGNGSTSPPPGQLPTPESTSTAMPGSWDFNPAASSAEPPDRETVTEPPDRADSPSHWLLESLEEATEAAVEADVDRDVTPTPTSRSGGGILDNQSSSRPIRRRNREGLDQSLIIEGKRERRRNRDPNYEYGSFLPLPPRSWNELLKHPLKQDFILAAGKEYTGLKQKETFKVVDINEAANHEILPVIWIFTYKFDENGNYLKAKARICVRGDLQARSAEENRAGTASARAFRSLMALVAAFDLDTDQKDAINAFLNAWLDQVIYARMPEGFKQPGKVWKVLKALYGLRKSPKLWQEELSAMLQEYGLEAVPEEECLFTSINLLVLFYVDDIIIINRPTPEARTEANRFKEALEARYELRHMGEVGWFLNIRVIRDRPNRKLWLCQDAYMDQMAAKFHLNDMTRWPETPLQPNMKLLHNEEQATPGQIHEYQQKTGSALFPTIITRPDAALAVNELARFSRNPSPSHMEAINQVIAYLYHTRYLALEFSASEYADEIFICTSDASFANNEDRKSTGGYLCKLFGAPIEWKSGKQRAVTTSTTEAEYVALAEAAKATYWWRRVFKSLEFDPGHTFARNEASYAMLISTDHGSGRRSRKGDFISNGSLPIR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-10-19" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C8V4D5</accession>
    <accession>Q15I80</accession>
    <accession>Q5B5I0</accession>
    <name>PFF1_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Vacuolar membrane protease</fullName>
            <ecNumber evidence="6">3.4.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">FXNA-related family protease 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="ORF">AN10522</name>
    </gene>
    <organism>
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in vacuolar sorting and osmoregulation.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="2">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase M28 family.</text>
    </comment>
    <comment type="sequence caution" evidence="6">
        <conflict type="erroneous gene model prediction">
            <sequence resource="EMBL-CDS" id="EAA59299" version="1"/>
        </conflict>
        <text>The predicted gene AN4200 has been split into 2 genes: AN10516 and AN10522.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="6"/>
    <dbReference type="EMBL" id="AACD01000068">
        <property type="protein sequence ID" value="EAA59299.1"/>
        <property type="status" value="ALT_SEQ"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF74498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V4D5"/>
    <dbReference type="SMR" id="C8V4D5"/>
    <dbReference type="FunCoup" id="C8V4D5">
        <property type="interactions" value="5"/>
    </dbReference>
    <dbReference type="STRING" id="227321.C8V4D5"/>
    <dbReference type="EnsemblFungi" id="CBF74498">
        <property type="protein sequence ID" value="CBF74498"/>
        <property type="gene ID" value="ANIA_10522"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AN10522"/>
    <dbReference type="eggNOG" id="KOG2194">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003436_0_0_1"/>
    <dbReference type="InParanoid" id="C8V4D5"/>
    <dbReference type="OMA" id="TPWPVTI"/>
    <dbReference type="OrthoDB" id="10257471at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd03875">
        <property type="entry name" value="M28_Fxna_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000057">
        <property type="entry name" value="Vacuolar membrane protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048024">
        <property type="entry name" value="Fxna-like_M28_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053975">
        <property type="entry name" value="PFF1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053976">
        <property type="entry name" value="PFF1_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="METALLOPEPTIDASE M28 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147:SF58">
        <property type="entry name" value="VACUOLAR MEMBRANE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22250">
        <property type="entry name" value="PFF1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22251">
        <property type="entry name" value="PFF1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0482">Metalloprotease</keyword>
    <keyword id="KW-0645">Protease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0926">Vacuole</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000413172" description="Vacuolar membrane protease">
        <location>
            <begin position="1"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Name=1" evidence="3">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="topological domain" description="Vacuolar" evidence="1">
        <location>
            <begin position="38"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Name=2" evidence="3">
        <location>
            <begin position="383"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="404"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Name=3" evidence="3">
        <location>
            <begin position="438"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="topological domain" description="Vacuolar" evidence="1">
        <location>
            <begin position="459"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Name=4" evidence="3">
        <location>
            <begin position="465"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="486"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Name=5" evidence="3">
        <location>
            <begin position="500"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="topological domain" description="Vacuolar" evidence="1">
        <location>
            <begin position="521"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Name=6" evidence="3">
        <location>
            <begin position="525"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="546"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Name=7" evidence="3">
        <location>
            <begin position="651"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="topological domain" description="Vacuolar" evidence="1">
        <location>
            <begin position="672"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Name=8" evidence="3">
        <location>
            <begin position="685"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="706"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Name=9" evidence="3">
        <location>
            <begin position="712"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="topological domain" description="Vacuolar" evidence="1">
        <location>
            <begin position="733"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="570"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="581"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="2">
        <location>
            <position position="309"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="4">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="4">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="4">
        <location>
            <position position="779"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P38244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="P80561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3"/>
    <evidence type="ECO:0000255" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="6"/>
    <sequence length="953" mass="106352" checksum="DC9DECF166A8BACC" modified="2009-11-03" version="1">MDQTKPPRRNPLAFTPWPVTLITAVVYLAFVIPLLVIHHVVPSAPTSSPDGLNITEAWNDLQVLTAGYRPYNSRQNDKIHDWLLHRINEILGAAPPATTDEKKPDVFVFDDTRSNLTFARDNLAVYFEGTNILVYIRGEDDDQEQWWELPEGSPKGKGGVLVNAHYDSVSTGYGATDDGVGVVTCLQLVKYFTTPKNAPRKGLVVLFNNGEEDFLNGARVYSQHPLSRFPHTFLNLEGAGAGGRAVLFRSSDAEVAASYMRSKHPFGSVLGSDGFKAGLIRSQTDYVVFEGDMGLRGLDVAFLEPRARYHTDQDDTRHTSKDSLWHMLSTAVATTEDLVSDTSDRFDGPARNDHKIASGTGHQAVWFDLYGSTFVLFRLHTLFALSVTLLVVAPIVLLLTSIILTKVDKMYLFRTSIRPEGSLEVLPLYGDRGVIRYPFLLGIPTAVTIGLAYLLTKFNPYIVHSSQYAVWSMMVSVWIFLAWFVSRVADFARPSAFHRVYTLTWTFVVMWVLQVIATVYQDRWALGGSYFIFFAYAGTFLATWISYLELFALPRKSEYANHLRPVSRHASSHSSRRGLSEEDEEDEDEAPTESTSLLGSRQRTTFANYVRVNADTADLSDSEEHTQDVNVYGLEQRWSASLPKWLWLLQFLLAAPIVLILVGPIALLLTGSLHQTGQDGSSSLFIYIAIVALTTLLLSPMLPFVHRCTYHIPLFMLAVFAGTLIYNLVAFPFSDSNRLKLFFIQEVDLDTGLNTASLTGVQPFVHDVAVGLPSAAGQNVTCGPFGDRFKCSWTGIPPHVLTEDKPVEEWLSFEVSRSIDKPRHAQLQISGQNTRACKVVFDSPIKNFHVAGSAYDPRFPHTYAKGIKEIRLWSRVWDNTWTVDVEWFNPDSSSDHSKTSGSLTGQVVCLWSDYNQPGTIPALDEVRQYGPAWIGVSKLADGLVEGRKSFEIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>C8V4E0</accession>
    <name>C8V4E0_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Dynamitin homolog (p50 subunit of dynactin) (Eurofung)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ANIA_03589</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
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            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
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    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
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            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
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        <scope>GENOME REANNOTATION</scope>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="EMBL" id="CBF75825.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
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            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
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    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
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                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
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            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
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        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_050611356.1"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
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        <source>
            <dbReference type="EMBL" id="CBF74985.1"/>
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        <source>
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<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF76203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467566.1">
        <property type="nucleotide sequence ID" value="XM_050611549.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V834"/>
    <dbReference type="STRING" id="227321.C8V834"/>
    <dbReference type="GeneID" id="2872845"/>
    <dbReference type="KEGG" id="ani:ANIA_05048"/>
    <dbReference type="eggNOG" id="KOG0490">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_674437_0_0_1"/>
    <dbReference type="InParanoid" id="C8V834"/>
    <dbReference type="OMA" id="CDESHQN"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0371">Homeobox</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="89"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF76203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="408" mass="43909" checksum="11578B42C3FB5D5B" modified="2009-11-03" version="1">MPEGDSFASDAVDKDERGQVEESSQTSVAISESPNSSQQAADSSLVELNAMQSPIDASSNALHPNSAKRKRSGSDLGETNKESATPSMLDSLKSPPSLRLSLSFDGEAMVRKQGELTPSPPKGRNSLRISMSADGQAVIRANGEPSPSKNRISMFPTRTPRLAGLRRSNSAVVLGTPRSLEREKSFGRSRDPRNWESIFDTDARSALATPFSSQSTPKSALLSGGKRSLTRSLSARHPSLLTPNSDTQGTPITQAMRQKRQKLSRTVSSLGRLESGRKALGEKFPSTLKNSKSAKDDLELEAGDSDKENWIPGTRVSQSRRRTVSSHTHRPVLKDSNGRDGRPHDASTSGRSRWSQPSHRKTVGPSKSLSMSGLEGDVSAFMGGNAASQEEDLDCIQGLLSLSQGAWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C8V840</accession>
    <name>C8V840_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ANIA_10623</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF76215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467568.1">
        <property type="nucleotide sequence ID" value="XM_050611551.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V840"/>
    <dbReference type="GeneID" id="74896510"/>
    <dbReference type="KEGG" id="ani:ANIA_10623"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN10623"/>
    <dbReference type="eggNOG" id="ENOG502SR1H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007531_2_0_1"/>
    <dbReference type="InParanoid" id="C8V840"/>
    <dbReference type="OMA" id="GMINQSA"/>
    <dbReference type="OrthoDB" id="3862662at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF10">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="6">
        <location>
            <begin position="163"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBF76215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="472" mass="54421" checksum="FFDD6FBB2018279A" modified="2009-11-03" version="1">MPLDQQDTLQAMFTRRSWPCSEHTRFWVSRPKRPSNCECTTKKGLERQRNRHLIDTSPSTMIYFDNMMTISLFHQPSFPEKLARITSPTQLAALLAAMFAFAVRFRPEEMDVNRRAAWFLNVALQQIDVALDECGDETPPLCLLQAYVLAAHCQLTQGVLGRAWRTLGSCVRLAYEMNLHLVDVQGPRNAAAAVDIARWCSDEEQRRAWWAIWEMDVFATTIRRTPTAMDWSQIEILLPVDDEHWFQCQLQESCFFEPDPIRRWKMLESCGNQSPKAWFIVINSLMKEAQRISSPRGIPSRSQSDQVDEAHHQLEIIANAIRCFQLALPNHLKYKNQDLMFDVRGARRLSSAVYNINMMTHLARLMVYRYDVFKGRVRVSLLSCDDQHNHDRSSSMREGEHAAIREYFDAADKILTIIQRSSADHIQYTMPFLSSTIWLASAVQLMRSQLCRPGTLKNVSASGTCIRPFSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2025-10-08" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>C8VA13</accession>
    <name>C8VA13_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short-chain dehydrogenase/reductase family protein, putative (AFU_orthologue AFUA_4G03280)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_11105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF78144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_682000.2">
        <property type="nucleotide sequence ID" value="XM_676908.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VA13"/>
    <dbReference type="GeneID" id="2868523"/>
    <dbReference type="KEGG" id="ani:ANIA_11105"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN11105"/>
    <dbReference type="eggNOG" id="KOG1208">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_44_4_1"/>
    <dbReference type="InParanoid" id="C8VA13"/>
    <dbReference type="OMA" id="MMCPGMV"/>
    <dbReference type="OrthoDB" id="542013at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF35">
        <property type="entry name" value="DEHYDROGENASE_REDUCTASE FAMILY PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF78144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="332" mass="36429" checksum="9E09119BEEC947AE" modified="2009-11-03" version="1">MGLFQPKVMPLPHGIDLTGKTAVVTGATAGLGLETARQILRLNVSTLVLAVRNTEKAQSCVADLFRDADIQARLTRPDIHVLECNMEQYSSVKSFSAKLKESIPRVDILILNAGIHSFVYEKTSDGHEKALQVNYLSNVLLLAELLPFLESTAEQTGSAVRITWLGSRTYYLSNSLEKSDILTYGGGILQYMDSEKASASAGMNQYSDRKLLCALFVYELASRLNRDKVTLNLVCPGMVKTDLGSNGPLWIRTLIEIVKILRARPVEVGGWLVLNAAVVAGKESHGSLIGDKEVTEPTKFIKSSAGQELQKRLWKETVEEMATLTELLSAFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>C8VAG2</accession>
    <name>C8VAG2_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ANIA_11625</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF78339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467823.1">
        <property type="nucleotide sequence ID" value="XM_050611842.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VAG2"/>
    <dbReference type="GeneID" id="74897184"/>
    <dbReference type="KEGG" id="ani:ANIA_11625"/>
    <dbReference type="HOGENOM" id="CLU_2622021_0_0_1"/>
    <dbReference type="InParanoid" id="C8VAG2"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF78339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="78" mass="8669" checksum="EFFC3FA58108CB34" modified="2009-11-03" version="1">MVLSDQRPEARGMTQTASANLLNLRPLFRPKSDAIKGILKSTVRKPRMSSMAELRAAYAVFLEAWAYVSTSDDDGKTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>C8VAG8</accession>
    <name>C8VAG8_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ANIA_08603</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF78350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467825.1">
        <property type="nucleotide sequence ID" value="XM_050611844.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VAG8"/>
    <dbReference type="FunCoup" id="C8VAG8">
        <property type="interactions" value="245"/>
    </dbReference>
    <dbReference type="GeneID" id="2868502"/>
    <dbReference type="KEGG" id="ani:ANIA_08603"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN8603"/>
    <dbReference type="eggNOG" id="KOG1208">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_44_6_1"/>
    <dbReference type="InParanoid" id="C8VAG8"/>
    <dbReference type="OMA" id="GKRLWEW"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF282">
        <property type="entry name" value="WW DOMAIN-CONTAINING OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="333"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="371"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBF78350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="417" mass="46157" checksum="1B5DF0006272B80C" modified="2009-11-03" version="1">MFITSAAAFVWANLNPTNYIGSVSFCPERDIPDLAGKVVLVTGGNTGLGKETIRQIIKHNPEQVFLAARSEEKAQNAIRELESTAPNIKITWLPLDLASTKSIHDAAETFRAHASRLDILILNAGVMSLPPGETDLGHEIQLGTNHTGHFLLTKLLLPVLLETAQKPDSDVRVISLSSIGHNLAPDFETILHQDELKKCNTNARYGASKAANIIFAAELARRYPSLTAVSVHPGIIVTELYAATSASNPIAALAVKLLGLIATKVEQGAWNQLWAAVGAKKGELVNGAYYTPVGIVKQRNRYVVDQKMGRRLWEWTETELKRDHKEGFIERMLQPHPHHQRRRSSVGEGEIEKPDLAIGLERQSSTERNEQGQNQAESGGQNVLRPQRRNSRLQRLKEFMHSEEELDDAGKTYAKLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>C8VAW2</accession>
    <name>C8VAW2_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ser/Thr protein phosphatase family (AFU_orthologue AFUA_5G08620)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ANIA_04713</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF76942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467657.1">
        <property type="nucleotide sequence ID" value="XM_050611652.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VAW2"/>
    <dbReference type="STRING" id="227321.C8VAW2"/>
    <dbReference type="GeneID" id="2872513"/>
    <dbReference type="KEGG" id="ani:ANIA_04713"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN4713"/>
    <dbReference type="eggNOG" id="KOG0371">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1073739_0_0_1"/>
    <dbReference type="InParanoid" id="C8VAW2"/>
    <dbReference type="OrthoDB" id="10267127at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050126">
        <property type="entry name" value="Ap4A_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42850">
        <property type="entry name" value="METALLOPHOSPHOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42850:SF4">
        <property type="entry name" value="ZINC-DEPENDENT ENDOPOLYPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="3">
        <location>
            <begin position="180"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBF76942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="259" mass="29091" checksum="2B19A27444D2B8D9" modified="2009-11-03" version="1">MADRDRSRDREALDISDDISEDGLYPPHPSSSSPPTRLSRFARPLIDYVRNEWQSNSGAKYSHLGSASSNSVSDRTDAPRWVQIVLSIVAAPRFRRYVLVYLALLGACILGWQFFLFPRLKENSAILTALDPKEKSKVGGWFGANAVPQLEDMIQLKTLDPALLPAREAKEDDSKHSSRRLVIVGDVHGCKEELEKLLDKVSFQEERDHLIFTGDLIEKGPDSLGVVDLARHYNASCVRGNHDRPPPCPPSRHARVQYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>C8VD04</accession>
    <name>C8VD04_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADPH-dependent FMN reductase Lot6, putative (AFU_orthologue AFUA_7G06600)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_07214</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF78846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467879.1">
        <property type="nucleotide sequence ID" value="XM_050611907.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VD04"/>
    <dbReference type="STRING" id="227321.C8VD04"/>
    <dbReference type="GeneID" id="2870018"/>
    <dbReference type="KEGG" id="ani:ANIA_07214"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN7214"/>
    <dbReference type="eggNOG" id="ENOG502R1TU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028280_0_0_1"/>
    <dbReference type="InParanoid" id="C8VD04"/>
    <dbReference type="OMA" id="GHTETYY"/>
    <dbReference type="OrthoDB" id="68575at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.405.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002993374" evidence="1">
        <location>
            <begin position="20"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF78846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="463" mass="51244" checksum="E45B7583E616161F" modified="2009-11-03" version="1">MRLGALLSVTLLSTAATAAFNAQDTIDRDVVILGGGATGTFAAVQLREQGYTVALVEQKSKLGGHAETLYLPSGDYVNYGVEGYFNNKITKDFFAQLDVDYEPLLPGAILTQHVNFRTGERVLPGNELLTTTAAALLYRGAIEQFNYLAQGLYDLPEEVPEILLRPFREFVDKYALWGAVDLIFTFAENVGNMLDRPTLYVIQYFGIPHIDALLNGGYIRPKNGTDVLFNKAANYIDEVNNIFYDSMAVRTTRDETGVEVVIQNARTGAQKLIRAKKLLIAFPPVLEKLAGFDLTEQESALFSKWTYVNYYAAVLTNTAVPNDFNILNTDPTNQPGSLPTTPFNWALEYSGVPGYFMNKIIGDANLTEAEARALIIDDLKRMSSAGTFGIKDGQEPEIAAFASHSPETLMVSVEDVKGGFYKKLYGLQGQASTFYTGYTFCTDYSTMLWNYTNTIVDRIVQEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>C8VI35</accession>
    <name>C8VI35_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glucooligosaccharide oxidase, putative (AFU_orthologue AFUA_6G14340)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ANIA_10388</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF83064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_660872.2">
        <property type="nucleotide sequence ID" value="XM_655780.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VI35"/>
    <dbReference type="STRING" id="227321.C8VI35"/>
    <dbReference type="GeneID" id="74896378"/>
    <dbReference type="KEGG" id="ani:ANIA_10388"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN10388"/>
    <dbReference type="eggNOG" id="ENOG502QVGN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018354_10_1_1"/>
    <dbReference type="InParanoid" id="C8VI35"/>
    <dbReference type="OMA" id="PRCSYLN"/>
    <dbReference type="OrthoDB" id="407275at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF17">
        <property type="entry name" value="OXIDASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14340)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002993143" evidence="5">
        <location>
            <begin position="18"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="41"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBF83064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="471" mass="50122" checksum="D2051EFE3255155C" modified="2009-11-03" version="1">MTALSTFATCLLASVGGDSSLVAFPQQPNYPNLVAPYNLDLLTTPVAIVFPEDTSQVAAAVKCAVDAGIKVQAKSGGHSYGNYGSPTDGLSINLENLQHFSVDTDTWITSFGPGNRLGRVTELQYNNGGRHTPHGSTFTVGLGGHATVGGAGAASRQLGLLVDYLEEVEVVLANSSVVRASKTQNTDLFFAIRGAGSSVGIVTDFAIRTEPAPPSTISYSYVWTETDSATRAQVFLSWQGLLASGSLPRNTGFDLVVTPSSIIVSGAYFGSQADFEALDFLSHFSTAPQTTQITPYTNFYKFAAAASARTIASGTAQPSHFYAKSLVFKQETLIPDEVAQAAFEYLDTTTNGTDLYAVTFNGLGGAVADVAPSETAFVHRDTLFFAFSFGRTASALTDTTIQFLNGLSDVLTSGHPDAYYGQYAGNVDPRESKEEAWAAYYGENLLRLKKVKAEVDPKDVFHNLQSVQPGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>C8VI66</accession>
    <name>C8VI66_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Thermophilic desulfurizing enzyme family protein (AFU_orthologue AFUA_8G01010)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ANIA_03239</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF83120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468423.1">
        <property type="nucleotide sequence ID" value="XM_050612510.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VI66"/>
    <dbReference type="STRING" id="227321.C8VI66"/>
    <dbReference type="GeneID" id="2874421"/>
    <dbReference type="KEGG" id="ani:ANIA_03239"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN3239"/>
    <dbReference type="eggNOG" id="ENOG502S9JP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018204_10_1_1"/>
    <dbReference type="InParanoid" id="C8VI66"/>
    <dbReference type="OMA" id="HNWDNVG"/>
    <dbReference type="OrthoDB" id="5356974at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008470">
        <property type="term" value="F:3-methylbutanoyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006552">
        <property type="term" value="P:L-leucine catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000020">
        <property type="entry name" value="Putative acyl-CoA dehydrogenase YdbM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000032">
        <property type="entry name" value="Thermophilic desulfurizing enzyme family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013107">
        <property type="entry name" value="Acyl-CoA_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884:SF12">
        <property type="entry name" value="ISOVALERYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08028">
        <property type="entry name" value="Acyl-CoA_dh_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase C-terminal" evidence="3">
        <location>
            <begin position="203"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBF83120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="364" mass="40096" checksum="3E05E274F9DCF97C" modified="2009-11-03" version="1">MAAASSRGVSGIRPFARWRRGTGMPIPIRFIVNDTVNQPGSRSIGMLLGYHLLWSTTANVVGTPKQIEQTHELIITNNYFVGGAVNPRDSDLKITSDGDSIIFNGAKFFNTGGVVSDLTVLEGVLEGTDSHIFALVETRQPGIQFAHNWHNIGLRLTESGGVKIENVRVPWTDALGWDAAQKKPREDILATSFAALLLPTIQLVFSNFYLGIALGSLQFASKYTTTTTRAWPYGGDNKPAATDEFYILERYGEFFAHLRAAEALADRAGDQLTSLYTKYSSNRTALTPQERGEVAEWVASVKIVTTDVGLKVTSGVFEVTGARATSLRVGLDRFWRDVRTHTLHDPVAYKRREVGRIIVYGMII</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>C8VJ36</accession>
    <name>C8VJ36_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Polymerase (RNA) II (DNA directed) polypeptide D (AFU_orthologue AFUA_3G08040)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ANIA_10362</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic RPB4 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF83701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468497.1">
        <property type="nucleotide sequence ID" value="XM_050612589.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VJ36"/>
    <dbReference type="STRING" id="227321.C8VJ36"/>
    <dbReference type="GeneID" id="74896357"/>
    <dbReference type="KEGG" id="ani:ANIA_10362"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN10362"/>
    <dbReference type="eggNOG" id="KOG2351">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_110332_0_0_1"/>
    <dbReference type="InParanoid" id="C8VJ36"/>
    <dbReference type="OMA" id="HRKTQNE"/>
    <dbReference type="OrthoDB" id="2186918at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.40:FF:000003">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit rpb4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006590">
        <property type="entry name" value="RNA_pol_Rpb4/RPC9_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045222">
        <property type="entry name" value="Rpb4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005574">
        <property type="entry name" value="Rpb4/RPC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038324">
        <property type="entry name" value="Rpb4/RPC9_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21297">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03874">
        <property type="entry name" value="RNA_pol_Rpb4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00657">
        <property type="entry name" value="RPOL4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="HRDC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNA polymerase Rpb4/RPC9 core" evidence="5">
        <location>
            <begin position="30"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBF83701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="149" mass="16821" checksum="28D6AB059B80F577" modified="2009-11-03" version="1">MSGVNLPPATHRQRAPPQGELEAASTLKLGADQNTHTLSLSEARLVIDKVLENKRRGGKKYEEPENLIKTLEYLSLFARFKDEENIKAVERLLNSHTELEMFERSQLGSLCCDNADEAKSLIPSLQNKISDGELQELLDELTKLRNFTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C8VJL5</accession>
    <name>C8VJL5_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ANIA_11365</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF84020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468542.1">
        <property type="nucleotide sequence ID" value="XM_050612643.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VJL5"/>
    <dbReference type="GeneID" id="74896963"/>
    <dbReference type="KEGG" id="ani:ANIA_11365"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN11365"/>
    <dbReference type="HOGENOM" id="CLU_2386137_0_0_1"/>
    <dbReference type="InParanoid" id="C8VJL5"/>
    <dbReference type="OrthoDB" id="3936150at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511:SF4">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBF84020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="94" mass="9887" checksum="FD1ACAC77DF1078B" modified="2009-11-03" version="1">MPNAAKEFNSQYQTLLSGSLYAGFLVGANACGLLADILGRKTVWQLSIFGVSTVTLLAASFPNWKAVNVWTVLCGLFGGGNLAIDLTALTEFSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C8VJX3</accession>
    <name>C8VJX3_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alpha-1,2-mannosyltransferase (Kre2), putative (AFU_orthologue AFUA_5G10760)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ANIA_02752</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 15 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF84088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468554.1">
        <property type="nucleotide sequence ID" value="XM_050612659.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VJX3"/>
    <dbReference type="FunCoup" id="C8VJX3">
        <property type="interactions" value="35"/>
    </dbReference>
    <dbReference type="GeneID" id="2874474"/>
    <dbReference type="KEGG" id="ani:ANIA_02752"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN2752"/>
    <dbReference type="eggNOG" id="KOG4472">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024327_4_1_1"/>
    <dbReference type="InParanoid" id="C8VJX3"/>
    <dbReference type="OMA" id="YCDIHYD"/>
    <dbReference type="OrthoDB" id="439943at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000032">
        <property type="term" value="P:cell wall mannoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000051">
        <property type="entry name" value="Alpha-1,2-mannosyltransferase (Ktr4)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002685">
        <property type="entry name" value="Glyco_trans_15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121">
        <property type="entry name" value="ALPHA-1,2 MANNOSYLTRANSFERASE KTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121:SF6">
        <property type="entry name" value="ALPHA-1,2 MANNOSYLTRANSFERASE KTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01793">
        <property type="entry name" value="Glyco_transf_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002991606" evidence="5">
        <location>
            <begin position="29"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="397"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBF84088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="464" mass="54879" checksum="83D4879A6C78BDE4" modified="2009-11-03" version="1">MPPIQGKYLRYLIFTLLGLALFLLSRRSIPVPDSSSSISTPPPPPSDRPVNAFGYSLNPQSSSEVVRFAASHPGGRANATFVTLARNSDVWEIAQAIRQVEDRFNRNFHYDWIFLNDQPFDDNFKRITTSLVSGTTRYGEIPKEHWSYPDWIDQDRAREVREEMKEKKIIYGHSESYRHMCRYESGFFFRHPLLQEYEFYWRIEPGVELFCDIPYDPFLFMKENDKKYSFVMSMYEYEGTIPTLWDSVKQFMDDHPEHIAEGNSLRFLSDDNGKTYNKCHFWSNFEIGSLDWLRSKEYLDYFDFLDRAGGFYYERWGDAPIHSIAAGLLLKKEQLHFWDEISYYHIPFTHCPRDEQLRMDLRCSCDPSGNFDWRGFSCLSRYYKTNNIPLPPGVDEYSWLAIFGIIVGLLAVAGIVATAVNHQARSHALQEVQYLYWQSQTLWERYQKEKREWERERMGRAWSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>C8VLT6</accession>
    <name>C8VLT6_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ANIA_11633</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF84738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468612.1">
        <property type="nucleotide sequence ID" value="XM_050612728.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VLT6"/>
    <dbReference type="GeneID" id="74897190"/>
    <dbReference type="KEGG" id="ani:ANIA_11633"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN11633"/>
    <dbReference type="HOGENOM" id="CLU_2542569_0_0_1"/>
    <dbReference type="InParanoid" id="C8VLT6"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF84738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="83" mass="9678" checksum="FDB1E1EF7D2AE399" modified="2009-11-03" version="1">MLLYPPTFVLGRWSRPAAVLRTSGIHALTFERFLFPAIEGHWAYCDSQNIAFPSREPYGLDSPDMKRWQQTYVISLDEIRQCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>C8VMP3</accession>
    <name>C8VMP3_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">amidase</fullName>
            <ecNumber evidence="3">3.5.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ANIA_10210</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a monocarboxylic acid amide + H2O = a monocarboxylate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:12020"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:35757"/>
            <dbReference type="ChEBI" id="CHEBI:83628"/>
            <dbReference type="EC" id="3.5.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amidase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.4" evidence="3"/>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF85015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468663.1">
        <property type="nucleotide sequence ID" value="XM_050612785.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VMP3"/>
    <dbReference type="FunCoup" id="C8VMP3">
        <property type="interactions" value="48"/>
    </dbReference>
    <dbReference type="STRING" id="227321.C8VMP3"/>
    <dbReference type="GeneID" id="2874580"/>
    <dbReference type="KEGG" id="ani:ANIA_10210"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN10210"/>
    <dbReference type="eggNOG" id="KOG1212">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009600_9_2_1"/>
    <dbReference type="InParanoid" id="C8VMP3"/>
    <dbReference type="OMA" id="QGLYSIC"/>
    <dbReference type="OrthoDB" id="6428749at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004040">
        <property type="term" value="F:amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043605">
        <property type="term" value="P:amide catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072:SF1">
        <property type="entry name" value="AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072">
        <property type="entry name" value="AMIDASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001221">
        <property type="entry name" value="Amidase_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="7">
        <location>
            <begin position="80"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="135"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="210"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="5">
        <location>
            <position position="234"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="231"/>
            <end position="234"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBF85015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="548" mass="60221" checksum="5D97034FCFA8BF94" modified="2009-11-03" version="1">MTEPHWKSIAHQKRLTQLQSIPSPWRLSSSSISSTSPKSPIEIIQTCGILSPQELRWTEVNDITELVCLLASRSVTSVQLTTAFCKRAAVAQQLTGCLTEIFFDRALQRAKFLDEEFERTGKVTGPLHGVPVSIKDRFDVEGFDTTIGWVGLANKPAAKSDSVVQLLESMGAVLYVKTNVPQSLMMSDSYNHVFGQSVNAFNTKLISGGSSGGEGALVGAGGSVLGIGTDIGGSIRVPSNLQGLYSLCPTTGRIPWNCSFMHQHYLVPPVAGPMARSVSTIEYFMQSLLDSNPWNLDPGCIPIPWRRETAAFPDPTRKLKLGIVYDDGVVRPQPPVMRLMRELARELTNAGHEVVEWDTSLHRTGTTLWTRSILADGGYHCRQLCSLVDEPLIQGMVVGTSADELSSVEKEKLEEEKYAFQESYLAQWVASGIDALLLPVTPWLGYKPKQWVQSNQWLGYTALFNLLNYAAVTAPIGKADGELDHPVAGIDNEWKGYAPRNKADRFNYDQYDIDLVKGMPVTVQIVGGRYGEEKAVAVAKVVDTLFGR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2016-09-07" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>C8VQ72</accession>
    <accession>Q5BH35</accession>
    <name>MDPA_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Monodictyphenone cluster transcriptional coactivator mdpA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Monodictyphenone synthesis protein A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">mdpA</name>
        <name type="ORF">ANIA_10021</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2010" name="Appl. Environ. Microbiol." volume="76" first="2067" last="2074">
            <title>Characterization of the Aspergillus nidulans monodictyphenone gene cluster.</title>
            <authorList>
                <person name="Chiang Y.M."/>
                <person name="Szewczyk E."/>
                <person name="Davidson A.D."/>
                <person name="Entwistle R."/>
                <person name="Keller N.P."/>
                <person name="Wang C.C."/>
                <person name="Oakley B.R."/>
            </authorList>
            <dbReference type="PubMed" id="20139316"/>
            <dbReference type="DOI" id="10.1128/AEM.02187-09"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2011" name="J. Am. Chem. Soc." volume="133" first="4010" last="4017">
            <title>Genome-based deletion analysis reveals the prenyl xanthone biosynthesis pathway in Aspergillus nidulans.</title>
            <authorList>
                <person name="Sanchez J.F."/>
                <person name="Entwistle R."/>
                <person name="Hung J.H."/>
                <person name="Yaegashi J."/>
                <person name="Jain S."/>
                <person name="Chiang Y.M."/>
                <person name="Wang C.C."/>
                <person name="Oakley B.R."/>
            </authorList>
            <dbReference type="PubMed" id="21351751"/>
            <dbReference type="DOI" id="10.1021/ja1096682"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2013" name="PLoS ONE" volume="8" first="e62088" last="e62088">
            <title>Identification of metabolic pathways influenced by the G-protein coupled receptors GprB and GprD in Aspergillus nidulans.</title>
            <authorList>
                <person name="de Souza W.R."/>
                <person name="Morais E.R."/>
                <person name="Krohn N.G."/>
                <person name="Savoldi M."/>
                <person name="Goldman M.H."/>
                <person name="Rodrigues F."/>
                <person name="Caldana C."/>
                <person name="Semelka C.T."/>
                <person name="Tikunov A.P."/>
                <person name="Macdonald J.M."/>
                <person name="Goldman G.H."/>
            </authorList>
            <dbReference type="PubMed" id="23658706"/>
            <dbReference type="DOI" id="10.1371/journal.pone.0062088"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2020" name="Microorganisms" volume="8" first="0" last="0">
            <title>Genome Wide Analysis Reveals the Role of VadA in Stress Response, Germination, and Sterigmatocystin Production in Aspergillus nidulans Conidia.</title>
            <authorList>
                <person name="Son Y.E."/>
                <person name="Park H.S."/>
            </authorList>
            <dbReference type="PubMed" id="32872591"/>
            <dbReference type="DOI" id="10.3390/microorganisms8091319"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="3 4">Transcriptional coactivator; part of the gene cluster that mediates the biosynthesis of monodictyphenone, a prenyl xanthone derivative (PubMed:20139316, PubMed:21351751). With mdpE, coregulates the production of monodictyphenone (PubMed:20139316, PubMed:21351751).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="5 6">Expression is negatively regulated by the gprB G-protein coupled receptor signaling pathway (PubMed:23658706). Expression is also negatively regulated by the spore-specific regulatory gene vadA in conidia (PubMed:32872591).</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="3 4">Impairs the production of monodictyphenone and of any of the intermediates of the pathway (PubMed:20139316, PubMed:21351751).</text>
    </comment>
    <comment type="sequence caution" evidence="8">
        <conflict type="erroneous gene model prediction">
            <sequence resource="EMBL-CDS" id="EAA66018" version="1"/>
        </conflict>
        <text>The predicted gene AN0145 has been split into 2 genes: ANIA_10021 and ANIA_10049.</text>
    </comment>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF90109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AACD01000005">
        <property type="protein sequence ID" value="EAA66018.1"/>
        <property type="status" value="ALT_SEQ"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VQ72"/>
    <dbReference type="SMR" id="C8VQ72"/>
    <dbReference type="STRING" id="227321.C8VQ72"/>
    <dbReference type="EnsemblFungi" id="CBF90109">
        <property type="protein sequence ID" value="CBF90109"/>
        <property type="gene ID" value="ANIA_10021"/>
    </dbReference>
    <dbReference type="GeneID" id="2875924"/>
    <dbReference type="KEGG" id="ani:ANIA_10021"/>
    <dbReference type="eggNOG" id="KOG3178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005533_11_0_1"/>
    <dbReference type="InParanoid" id="C8VQ72"/>
    <dbReference type="OMA" id="LLACIQW"/>
    <dbReference type="OrthoDB" id="1606438at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF15">
        <property type="entry name" value="MONODICTYPHENONE CLUSTER TRANSCRIPTIONAL COACTIVATOR MDPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_0000437060" description="Monodictyphenone cluster transcriptional coactivator mdpA">
        <location>
            <begin position="1"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="HTH iclR-type" evidence="1">
        <location>
            <begin position="77"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="281"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="314"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="289"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="314"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="20139316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="21351751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="23658706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="6">
        <source>
            <dbReference type="PubMed" id="32872591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="7">
        <source>
            <dbReference type="PubMed" id="20139316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="8"/>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBF90109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="479" mass="51980" checksum="F8D83D97DD52254C" modified="2009-11-03" version="1">MMSSLSDLETHASELTSAVKTIISQCPRQNAASRSRTQPLITSSASKEAHRAQQSILSTISGLQKLLTSPTDFLHHLAVQNQLLACLQWLGEFQVLACIPLTGTVPIKDVAELAGVPETHLSRIIRMTATAGFLDEPDPGQVAHSALSAPFVTKPSYLDAVMFLAGTIAPSALQMPTATQRFGASLRPNETAYNLALNNPATFASTSEQRPKLQRQWPAFLQYGTSDTDDRVTDLLSRLDHFRRGSISVVEVSARSLDRATTLANLYPSINITVQIASPAGPTAWSPAHPNPIRPPTPGGSHKHDDLRALTASTASTTPASSHNHTHTHTTNSIPQASNITIQHRLPTAPQPITSANLYILHLPSPSPTVPFASLATHILAELRSHLDILRSNPSATLILTPRPLPEPSAVHSEVEASARLRDLTLMQLANEREIELAEWINLLSNVSDSMGRLVVVNKIQSRESTVVLLEIRYQAYNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>C8VQE2</accession>
    <name>C8VQE2_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_00833</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF88695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050469123.1">
        <property type="nucleotide sequence ID" value="XM_050613295.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VQE2"/>
    <dbReference type="STRING" id="227321.C8VQE2"/>
    <dbReference type="GeneID" id="2876607"/>
    <dbReference type="KEGG" id="ani:ANIA_00833"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN0833"/>
    <dbReference type="eggNOG" id="ENOG502T1RW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_126083_0_0_1"/>
    <dbReference type="InParanoid" id="C8VQE2"/>
    <dbReference type="OMA" id="WQTRERP"/>
    <dbReference type="OrthoDB" id="4147798at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF88695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="117" mass="13587" checksum="9525B53665147ECF" modified="2009-11-03" version="1">MGQRHNRRRTRPRSRNSVNKTLTPSAISPPADLLCTSSYRYSLDCLENRPASTRHYRGLTWQPSEYLKPDMIIMETEQFRLFGGEPGDDVDLCYRMLEYFGGLDFIDPLQEFKPLPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>C8VR81</accession>
    <name>C8VR81_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Zn(II)2Cys6 transcription factor (Eurofung)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ANIA_11216</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF87498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468972.1">
        <property type="nucleotide sequence ID" value="XM_050613133.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VR81"/>
    <dbReference type="GeneID" id="2867811"/>
    <dbReference type="KEGG" id="ani:ANIA_11216"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN11216"/>
    <dbReference type="eggNOG" id="ENOG502QWTJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008241_3_0_1"/>
    <dbReference type="InParanoid" id="C8VR81"/>
    <dbReference type="OMA" id="YNTDILC"/>
    <dbReference type="OrthoDB" id="2563500at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF7">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00755">
        <property type="entry name" value="AFLATOXINBRP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="20"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="70"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="117"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBF87498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="547" mass="61874" checksum="78CAF51A4FF8D8A7" modified="2009-11-03" version="1">MDNSQQQQQQQSQRRRSKSGCNTCRARKVKCDERPEGCANCERLQLECSGYGRSAVQRSGTRRARRTYRSCTNCRLRRAKCSGERPACMRCRSRHLECRYGDNVEPAWSQRLAGIADPPDGSSPPGEETEGEGLPLTWVDEELSPDLGPSALLHIVCALGAHTTCQQLSPEFILRSGRRWAEKAYEMVLKDLDKISVDNLMASQLLYDYALRVGNFAQAFMLGGITARMVQALQLNLEYSTDVLCTEPGLSISAREARRRLMWSCFVTDALLGSGVDQLMLIDERDIKIQLPCNERRFVQETACVTRTLDGGVLGFLQPDTIPINPDENMGIMAYFVQHIQVRKQVLRYIKHLDTAISPWLPNSEFAILDKACWKWYDNLPESLQFTTSTIYARKASSQLGALVLLHCSHYQTLCDLYRLGAPALFKLRSAIDFPPEQSEFLQKLRGDLYNAARTLATIIGEAERHGPYILSDTWLPTITYDSSRIMLYYLTQLIDPREQDSKELVVQTIPYLESNIRALKAMQPLNAVSERLVRLPQTTKPSLTGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>C8VRD5</accession>
    <name>C8VRD5_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">GTP binding protein (GTPBP1), putative (AFU_orthologue AFUA_5G12580)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ANIA_10003</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF90308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050469351.1">
        <property type="nucleotide sequence ID" value="XM_050611087.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VRD5"/>
    <dbReference type="STRING" id="227321.C8VRD5"/>
    <dbReference type="GeneID" id="74896146"/>
    <dbReference type="KEGG" id="ani:ANIA_10003"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN10003"/>
    <dbReference type="eggNOG" id="KOG0463">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012821_0_0_1"/>
    <dbReference type="InParanoid" id="C8VRD5"/>
    <dbReference type="OMA" id="FRFIQRP"/>
    <dbReference type="OrthoDB" id="248233at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006414">
        <property type="term" value="P:translational elongation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd04165">
        <property type="entry name" value="GTPBP1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03694">
        <property type="entry name" value="GTPBP_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03708">
        <property type="entry name" value="GTPBP_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000014">
        <property type="entry name" value="Probable GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000091">
        <property type="entry name" value="Probable GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050055">
        <property type="entry name" value="EF-Tu_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035531">
        <property type="entry name" value="GTPBP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721">
        <property type="entry name" value="ELONGATION FACTOR TU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721:SF9">
        <property type="entry name" value="GTP-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="5">
        <location>
            <begin position="186"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="28"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="601"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="611"/>
            <end position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBF90308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="622" mass="68807" checksum="3BAADD6D4FF4B16B" modified="2009-11-03" version="1">MRTDSLKPSLEDRRRGELALSEFAEYADKQQSLRSAQTAPINSGTSDKSSAHEEHAELEILDQLGLSDEPKTVRLKDLLLRTDSKSEENLKALAELLQSRIDEGHGETIFDLGVEDGGESMSLSLDQWNIALNRLREAATTLSAHCRILLTYNVGGPEEAKTTNYRIKGSWGKILIRQPAETIEEMAEIRMAVVGNVDAGKSTMLGVLVKGGLDDGRGKARVNLFRHKHEIESGRTSSVGLEIMGFDSQGEIVSSSQGRKLSWEEIGKRSAKVISFSDLAGHERYLRTTVFGMLSSNPNYCLLMVAANNGLIGMSKEHLGIALALNVPVMVIITKIDICPPQILQETISQLTKILKSPGARKIPIFVKDMEETINTATQFVSQRICPIFQVSNVTGENLELVRTFLNILPYRGQYNPDAPFEFLINDTFSVPHVGTVVSGVAKSGVIHAGDSVLVGPDSLGQFTTTTIKSIERKRIQVNACFAGQSGSFALKRVRRKEVRKGMVVLKKLDQQPKVYREFIAEVLILSHATTIKPRYQAMLHVGAVSQTCSVIDIDRPYIRTGDRALVAFRFMQRPEFLAPGDRVLFREGKTKGLGIVKSVGYDSSNPLSPEARKEYERKEKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>C8VRE7</accession>
    <name>C8VRE7_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ubiquitin ligase subunit CulD, putative (AFU_orthologue AFUA_5G12680)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ANIA_10008</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the cullin family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF90329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050469357.1">
        <property type="nucleotide sequence ID" value="XM_050611093.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VRE7"/>
    <dbReference type="FunCoup" id="C8VRE7">
        <property type="interactions" value="781"/>
    </dbReference>
    <dbReference type="STRING" id="227321.C8VRE7"/>
    <dbReference type="GeneID" id="2875814"/>
    <dbReference type="KEGG" id="ani:ANIA_10008"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN10008"/>
    <dbReference type="eggNOG" id="KOG2167">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004747_7_0_1"/>
    <dbReference type="InParanoid" id="C8VRE7"/>
    <dbReference type="OMA" id="NYQEQTW"/>
    <dbReference type="OrthoDB" id="27073at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080008">
        <property type="term" value="C:Cul4-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000014">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.130:FF:000006">
        <property type="entry name" value="Cullin-4 like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000049">
        <property type="entry name" value="Putative ubiquitin ligase subunit CulD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000031">
        <property type="entry name" value="Ubiquitin ligase subunit CulD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000035">
        <property type="entry name" value="Ubiquitin ligase subunit CulD, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000044">
        <property type="entry name" value="Ubiquitin ligase subunit CulD, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.130">
        <property type="entry name" value="Cullin, Chain C, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045093">
        <property type="entry name" value="Cullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059120">
        <property type="entry name" value="Cullin-like_AB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016157">
        <property type="entry name" value="Cullin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001373">
        <property type="entry name" value="Cullin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019559">
        <property type="entry name" value="Cullin_neddylation_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11932">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00888">
        <property type="entry name" value="Cullin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26557">
        <property type="entry name" value="Cullin_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10557">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00182">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00884">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01256">
        <property type="entry name" value="CULLIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="8" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Cullin family profile" evidence="7">
        <location>
            <begin position="510"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="29"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="71"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="98"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBF90329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="880" mass="100047" checksum="75B7ACC7260A7F02" modified="2009-11-03" version="1">MQQNSRSPPEQRSGKRKATGKRKFPDQGELSQQPRHQQATISELLHRNQAQNQAQEQDDEHLPPTNKRVRPSSSSIAANQPESGDMYSFSTAEPKPNGPNTGGLTLSNSTLQARPGTSSHQSNFTPHTGARRLVVKNLRTGPRLNQDSYFDKVWGQLDAALSAIFSGGKPEISLEELYKGAENVCRQGRATILAKRLQERCRQHVTGKLHGSLVDKAQMAYNIETLRSVVEAWKEWQSMLITVRWIFYYLDQSFLLHSKEHPVIREMGLQQFRQHIYSDPTLQEKILQGACDLVSADRSDENGIVADSSLLRNAIELFHSLDVYVSGFEPVLVSGSKDFFSLWAQQEATGYLASYVENSHRLIEREMNRCEQFSFNRTTKQKLSESLDQTLVTDQESVLLSQKDVLGLLRIGNKIALGQLYTLLERRDLGAKLKGAFSTYIVEEGTGIVFDESEADMVVRLLSFKKQLDDIWNESFRRNEGLGHALRESFESFMNKGRKSDATGGTDNPKTGEMIAKYVDRLLRGGWRLAPTREAENMPLADEDAEINRQLDQVLDLFRFVHGKAVFEAFYKNDLARRLLMGRSASDDAEKSMLARLKTECGSSFTHNLESMFKDMEVARDEMSAYNSIKRERQTPLPVDLHVSVLSASAWPTYPDVQVRIPPEIATAISDFEKFYDTKYNGRKLAWKHQLAHCQLRARFPNGNKELVVSSFQAIVLLLFNELPEGGTLNYRQIQEATTLSDQELTRTLQSLACAKYRVLSKKPKGRDVSPTDEFSYNASFTDPKFRIKINQIQLKETKEENKTTHERVAADRHYETQAAIVRIMKSRKTITHAELVAEVIKATRSRGVLEPADIKKNIEKLIEKDYMEREDGNRYQYVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>C8VU37</accession>
    <name>C8VU37_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_10065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF89757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050469260.1">
        <property type="nucleotide sequence ID" value="XM_050610985.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VU37"/>
    <dbReference type="GeneID" id="74896182"/>
    <dbReference type="KEGG" id="ani:ANIA_10065"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN10065"/>
    <dbReference type="eggNOG" id="ENOG502T3R7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_561360_0_0_1"/>
    <dbReference type="InParanoid" id="C8VU37"/>
    <dbReference type="OMA" id="TDIKFHI"/>
    <dbReference type="OrthoDB" id="4158501at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF89757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="495" mass="55567" checksum="0BF8D792018C061D" modified="2009-11-03" version="1">MGSNRSYSHFWDLTLRKFFPKRESLSGTTTGSRSQSSWGGPGSSPTDEHTDGFYKYSQEVLEQEKHDGFRLRSSDSTAGSYASALMGPSDRPPLPYTVSAPDWNIFSPYVKYLDELENDSVCDWLGSVLSVWTGVYAVSKVVVMAFMHYGVELEDTPDGILAHTKRAEELVVSNSIIDLIDNTESLYYAVYARLIMEIAAADLCASFTLEVRRLATNSTFILPEPRQLCKILFNCKQALDGSTICVNLNKELVRQHQLDFIRRASDKIQDAGFVLDDLIGYRQHAIKIVSDKSSNFRQKWGKASVLYEMPPENVLALQSEKYLSLSPKPAVQQVVPLLRLPFIEPDTIPTSIRERDIIMDNRQATLAKLEGKCVGEARRTEGRRRLIDLVRERKCICRSVCICAHDCTQDVERHCPCSERLLSLMVAKRRNSVGPLPFGPRCSALAKAIFHGIASVRPDADDIELTAEIDRATMIFIEEVRKQRSANIFSHGAGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>C8VU77</accession>
    <name>C8VU77_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aminotransferase, class III (AFU_orthologue AFUA_1G16810)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ANIA_00991</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF88382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050469094.1">
        <property type="nucleotide sequence ID" value="XM_050613265.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VU77"/>
    <dbReference type="STRING" id="227321.C8VU77"/>
    <dbReference type="GeneID" id="2876772"/>
    <dbReference type="KEGG" id="ani:ANIA_00991"/>
    <dbReference type="eggNOG" id="KOG1404">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016922_4_0_1"/>
    <dbReference type="InParanoid" id="C8VU77"/>
    <dbReference type="OMA" id="REGLNQH"/>
    <dbReference type="OrthoDB" id="5419315at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000004">
        <property type="entry name" value="Acetylornithine aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005685">
        <property type="entry name" value="PRK07483.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43094">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43094:SF2">
        <property type="entry name" value="AMINOTRANSFERASE, CLASS III (AFU_ORTHOLOGUE AFUA_1G16810)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBF88382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="448" mass="48057" checksum="B4F3AEA23A5CB799" modified="2009-11-03" version="1">MTSAVLHRDTRFVPKKAVGGKGSYLLLEDGTKFLDSTGGAAVSCLGHGHEKIIQAITEQFTKVEYCHTAFFGTEASENLASLLVDSTGGKLSKLFVVSSGSEAVEAALKLARQYFLELPTPQPQRTRFIARKPSYHGTTLGALGVGGHALRRQPFEPILSQNVSHVSPCYAYRGKNDGESDADYVARLAGELDAEFRRVGPDTVCAFIAEPIVGAALGCVPAVPGYFAAMKTICEKHGALFILDEIMCGMGRCGTLHAWEQEDVTPDLQTIGKALGGGYAPVSGLLISDKVVQTVDKGTGAFRHGQTYQGHPISCAAALAVQTVIVEEQLLDNVKSMGEYLEKRLRGTLEGMQYVGDIRGKGLFWGVEFVKNKATKEPFSSETALAFKIQETGMKPEFGISLYAGTGTVNGTRGDHIILAPAYNVTKEEIDIIVDTTAKVLAEVFAQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>C8VUR4</accession>
    <name>C8VUR4_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphoglycerate mutase family protein (AFU_orthologue AFUA_1G15740)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_00908</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF88546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050469107.1">
        <property type="nucleotide sequence ID" value="XM_050613279.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VUR4"/>
    <dbReference type="FunCoup" id="C8VUR4">
        <property type="interactions" value="132"/>
    </dbReference>
    <dbReference type="STRING" id="227321.C8VUR4"/>
    <dbReference type="GeneID" id="2876684"/>
    <dbReference type="KEGG" id="ani:ANIA_00908"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN0908"/>
    <dbReference type="eggNOG" id="ENOG502S2Z2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042838_1_1_1"/>
    <dbReference type="InParanoid" id="C8VUR4"/>
    <dbReference type="OMA" id="ICAHAAP"/>
    <dbReference type="OrthoDB" id="414418at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1240:FF:000074">
        <property type="entry name" value="Phosphoglycerate mutase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051710">
        <property type="entry name" value="Phosphatase_SH3-domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16469:SF51">
        <property type="entry name" value="TRANSCRIPTION FACTOR TAU 55 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16469">
        <property type="entry name" value="UBIQUITIN-ASSOCIATED AND SH3 DOMAIN-CONTAINING BA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="329"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF88546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="354" mass="38654" checksum="7A67E4DA00FA2C40" modified="2009-11-03" version="1">MPLDTIYLTRHGHRLNWTIDYRTGTYSSQFPTPTGNPSDPTLTSHGVQQSHELAAHLVSGDVMPKPFRVYSSPFWRCLQTIEPAVRALKGAKEMSKGNEVGGETGGIDMNAEFEIRVENGLGEWFGSTTFFHHPTPPSLSTLLSLPKSNFEKSEPPFTLDTTRSVPLLYTSTQGESIPQLHNRLATTLAGIIREVDAEVFELEASLPPEQRSSKAILICSHAAPLIAIGRVLTGHMPEDSSEEDFHVFTAGLSTFRRRRNEATYRLGYVAQKREGKALAEGTRITDPTTTAVPEWEGGKGVGGGWDCVVNGDCSFLSGGAERGWHFNGEESFDTGPMADTASSAEGEMRLGNKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-12-14" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>G5EB22</accession>
    <accession>C8V081</accession>
    <name>G5EB22_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ANIA_05822</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF70777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_663426.1">
        <property type="nucleotide sequence ID" value="XM_658334.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G5EB22"/>
    <dbReference type="FunCoup" id="G5EB22">
        <property type="interactions" value="260"/>
    </dbReference>
    <dbReference type="STRING" id="227321.G5EB22"/>
    <dbReference type="GeneID" id="2870945"/>
    <dbReference type="KEGG" id="ani:ANIA_05822"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN5822"/>
    <dbReference type="eggNOG" id="KOG0601">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009707_0_0_1"/>
    <dbReference type="InParanoid" id="G5EB22"/>
    <dbReference type="OMA" id="DSIVRWM"/>
    <dbReference type="OrthoDB" id="5337378at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901892">
        <property type="term" value="P:negative regulation of cell septum assembly"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010972">
        <property type="term" value="P:negative regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110031">
        <property type="term" value="P:negative regulation of G2/MI transition of meiotic cell cycle"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd14052">
        <property type="entry name" value="PTKc_Wee1_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000536">
        <property type="entry name" value="Cyclin-dependent kinase WEE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000611">
        <property type="entry name" value="Protein kinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050339">
        <property type="entry name" value="CC_SR_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042:SF196">
        <property type="entry name" value="MITOSIS INHIBITOR PROTEIN KINASE SWE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="678"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="37"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="93"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="489"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="40"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="56"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="249"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="264"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="320"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="346"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="383"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="558"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="582"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="616"/>
            <end position="629"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBF70777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="1050" mass="114906" checksum="56050B6E1E1F56C7" modified="2011-12-14" version="1">MVATFSPHRDAGGTLHLSSHSGIHHIDANTAIRQLRRSFSRSPSKSSSFSLLTSRNHSPSKNTSYVSSPLSPSRRSAQGNFVLFPSSSQQSPFAIPYPPSAKISRPTMRRARTSPRSPVKRALNVSSDQGNAKPLHETPVTPGVENSSTIPEISLSPDDIGGGFSTCSNESSIYAEGTPNPRPSASRIEKRRSGTFNSAVSPMKRSDGIMNLDRASRGSPSAKRRSVQAVNLPGDFSIFDSENVTNTPEDPKTEETDLEKDAIFFPTSTTPPFSPFATVPRRTSSLRRSTLQQRSNDRSLFSRPRTMGDSEDLDAGTPLTVRSRQSLDANTPQPHRESLFSPRPAQVSSLFSNSNGATSRPAAHPLSRTITQSSSSSSLVDDSPTHEPPQKSDRPRAIINFSKSLPAGATRPSGARHLTREDSTSSTDSFATPENYKLVKPLPAAFMSTGLISKKNRNADDSHSLLGFSKNMPDTPCKRPVNLFAASQKAQPDGPLGRPAWSNAVDMPPPSPFNPSSARPKQGPFARGMGIFGTNFNRQGASRRGSLASIDGDDGYGLQTQSPSNRQNSQPLSESDFPPTPTKQSFFPSRTYPPTASQIASLERLSEARGTNSSPLHDRFQHESPRPNDRQSAQPDFNPLNLPATPTGPRDSFVGKRPSLPLNIHNTPDVDACLTSRFERVELVGTGEFSQVYRVSQPNGVSLPSIFSTTPKSLNSLPDQVWAVKKSKQPYSGLKDRERRIREVDALKALTNYDHIISFADSWEDNGHLYIQTEYCEEGSLDVFLAQVGLKARLDDFRIWKILLELSTGLKHIHDSGFIHLDLKPANILVTFEGVLKIADFGMASRWPAEEGIEGEGDREYIGPEILMGRYDKPADIFSLGLIIFEIAGNVELPDNGLSWQKLRNGDMSDVPSLTWSSETTVFRDASGNPISEEPSFEELCASDFGDDDFGTTDLFGSNRERKPVPFTRSSELADPPAFMIDAGHEQSLDKIVRWMISPEPLDRPTADHILESYGVQFVASRRRAGATVYEGNWGPADDVLAEDAEMIDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-12-14" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>G5EB79</accession>
    <accession>C8VCF8</accession>
    <name>G5EB79_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Pyrroline-5-carboxylate reductase</fullName>
            <ecNumber evidence="9">1.5.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">ANIA_07387</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-proline + NADP(+) = (S)-1-pyrroline-5-carboxylate + NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:14109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17388"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="EC" id="1.5.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the pyrroline-5-carboxylate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.2" evidence="9"/>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF78484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_680656.1">
        <property type="nucleotide sequence ID" value="XM_675564.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G5EB79"/>
    <dbReference type="STRING" id="227321.G5EB79"/>
    <dbReference type="GeneID" id="2869841"/>
    <dbReference type="KEGG" id="ani:ANIA_07387"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN7387"/>
    <dbReference type="eggNOG" id="KOG3124">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042344_3_1_1"/>
    <dbReference type="InParanoid" id="G5EB79"/>
    <dbReference type="OMA" id="AKQTCLG"/>
    <dbReference type="OrthoDB" id="10263291at2759"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00361"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004735">
        <property type="term" value="F:pyrroline-5-carboxylate reductase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3730.10:FF:000001">
        <property type="entry name" value="Pyrroline-5-carboxylate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000105">
        <property type="entry name" value="Pyrroline-5-carboxylate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3730.10">
        <property type="entry name" value="ProC C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01925">
        <property type="entry name" value="P5C_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053790">
        <property type="entry name" value="P5CR-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029036">
        <property type="entry name" value="P5CR_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000304">
        <property type="entry name" value="Pyrroline-COOH_reductase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00112">
        <property type="entry name" value="proC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645">
        <property type="entry name" value="PYRROLINE-5-CARBOXYLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645:SF0">
        <property type="entry name" value="PYRROLINE-5-CARBOXYLATE REDUCTASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14748">
        <property type="entry name" value="P5CR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000193">
        <property type="entry name" value="Pyrrol-5-carb_rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00521">
        <property type="entry name" value="P5CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8 9" id="KW-0521">NADP</keyword>
    <keyword evidence="7 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 9" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyrroline-5-carboxylate reductase catalytic N-terminal" evidence="11">
        <location>
            <begin position="8"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="Pyrroline-5-carboxylate reductase dimerisation" evidence="12">
        <location>
            <begin position="173"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="226"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="227"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="12"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>NADPH</name>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="72"/>
            <end position="75"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000193-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF14748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CBF78484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="283" mass="29376" checksum="E8A5EF7727676CE9" modified="2011-12-14" version="1">MPALQSSKLAFIGGGNMASAIIGGLLSQGINKQNITVSEPWEVNRNKIADLGVKTTTSNVVAGGEADLVIIAVKPQVTKAVCEELADAWSKRETLPVVVSIAAGITLGSLQQWLKTSDGRTTHLVRVMPNTPALVGEGASGLFASADVTAEEKELVNALLGSVSKATEWVDKEELIDVVTGLSGSGPAYFFAMVEHLIASATALGLPAEQATRLAAQTCLGAGKMLTESSDSPTQLRKNVTSPNGTTHAALETFNAQHFDQVVDKAVKAATSRAAELGNTLGK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2020-10-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>P9WEV8</accession>
    <accession>C8VQ65</accession>
    <accession>Q5BH29</accession>
    <name>MDPH1_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Decarboxylase</fullName>
            <ecNumber evidence="1">4.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Monodictyphenone synthesis protein H-1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">mdpH-1</name>
        <name type="ORF">ANIA_10022</name>
    </gene>
    <organism>
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2010" name="Appl. Environ. Microbiol." volume="76" first="2067" last="2074">
            <title>Characterization of the Aspergillus nidulans monodictyphenone gene cluster.</title>
            <authorList>
                <person name="Chiang Y.M."/>
                <person name="Szewczyk E."/>
                <person name="Davidson A.D."/>
                <person name="Entwistle R."/>
                <person name="Keller N.P."/>
                <person name="Wang C.C."/>
                <person name="Oakley B.R."/>
            </authorList>
            <dbReference type="PubMed" id="20139316"/>
            <dbReference type="DOI" id="10.1128/AEM.02187-09"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>PATHWAY</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2011" name="J. Am. Chem. Soc." volume="133" first="4010" last="4017">
            <title>Genome-based deletion analysis reveals the prenyl xanthone biosynthesis pathway in Aspergillus nidulans.</title>
            <authorList>
                <person name="Sanchez J.F."/>
                <person name="Entwistle R."/>
                <person name="Hung J.H."/>
                <person name="Yaegashi J."/>
                <person name="Jain S."/>
                <person name="Chiang Y.M."/>
                <person name="Wang C.C."/>
                <person name="Oakley B.R."/>
            </authorList>
            <dbReference type="PubMed" id="21351751"/>
            <dbReference type="DOI" id="10.1021/ja1096682"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>PATHWAY</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2012" name="ChemBioChem" volume="13" first="1680" last="1688">
            <title>Genetic and biosynthetic studies of the fungal prenylated xanthone shamixanthone and related metabolites in Aspergillus spp. revisited.</title>
            <authorList>
                <person name="Simpson T.J."/>
            </authorList>
            <dbReference type="PubMed" id="22730213"/>
            <dbReference type="DOI" id="10.1002/cbic.201200014"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2013" name="PLoS ONE" volume="8" first="e62088" last="e62088">
            <title>Identification of metabolic pathways influenced by the G-protein coupled receptors GprB and GprD in Aspergillus nidulans.</title>
            <authorList>
                <person name="de Souza W.R."/>
                <person name="Morais E.R."/>
                <person name="Krohn N.G."/>
                <person name="Savoldi M."/>
                <person name="Goldman M.H."/>
                <person name="Rodrigues F."/>
                <person name="Caldana C."/>
                <person name="Semelka C.T."/>
                <person name="Tikunov A.P."/>
                <person name="Macdonald J.M."/>
                <person name="Goldman G.H."/>
            </authorList>
            <dbReference type="PubMed" id="23658706"/>
            <dbReference type="DOI" id="10.1371/journal.pone.0062088"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2020" name="Microorganisms" volume="8" first="0" last="0">
            <title>Genome Wide Analysis Reveals the Role of VadA in Stress Response, Germination, and Sterigmatocystin Production in Aspergillus nidulans Conidia.</title>
            <authorList>
                <person name="Son Y.E."/>
                <person name="Park H.S."/>
            </authorList>
            <dbReference type="PubMed" id="32872591"/>
            <dbReference type="DOI" id="10.3390/microorganisms8091319"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="3 9 10">Decarboxylase; part of the gene cluster that mediates the biosynthesis of monodictyphenone, a prenyl xanthone derivative (PubMed:20139316). Within the pathway, mdpH-1 probably converts atrochrysone carboxylic acid to atrochrysone (Probable). The pathway begins with the synthesis of atrochrysone thioester by the polyketide synthase (PKS) mdpG. The atrochrysone carboxyl ACP thioesterase mdpF then breaks the thioester bond and releases the atrochrysone carboxylic acid from mdpG. The atrochrysone carboxylic acid is then converted to atrochrysone by mdpH-1 which is further transformed into emodin anthrone. The next step is performed by the anthrone oxygenase mdpH-2 that catalyzes the oxidation of emodinanthrone to emodin. Emodin is further modified to yield monodictyphenone via several steps involving mdpB, mdpC and mdpL. Mdpj and mdpK are part of a branching pathway leading to arugosin F, which is further converted to shamixanthone and epishamixanthone via several intermediates including arugosins I, H, A, B or variecoxanthone A. These reactions are performed by the FAD-dependent monooxygenase mdpD, the xanthone prenyltransferases xptA and xptB and the dehydrogenase xptC.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(3R)-atrochrysone 2-carboxylate + H(+) = (3R)-atrochrysone + CO2</text>
            <dbReference type="Rhea" id="RHEA:64264"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:234106"/>
            <dbReference type="ChEBI" id="CHEBI:234107"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:64265"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="induction">
        <text evidence="5 6">Expression is positively regulated by the gprD G-protein coupled receptor signaling pathway (PubMed:23658706). Expression is also negatively regulated by the spore-specific regulatory gene vadA in conidia (PubMed:32872591).</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="3 4">Impairs the production of monodictyphenone, but leads to the accumulation of endocrocin (PubMed:20139316, PubMed:21351751).</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the tpcK family.</text>
    </comment>
    <comment type="sequence caution" evidence="8">
        <conflict type="erroneous gene model prediction">
            <sequence resource="EMBL-CDS" id="CBF90095" version="1"/>
        </conflict>
        <text>The predicted gene ANIA_10022 has been split into 2 genes: mdpH-1 and mdpH-2.</text>
    </comment>
    <comment type="sequence caution" evidence="8">
        <conflict type="erroneous gene model prediction">
            <sequence resource="EMBL-CDS" id="EAA66024" version="1"/>
        </conflict>
        <text>The predicted gene AN0151 has been split into 2 genes: ANIA_10022 and ANIA_10035. ANIA_10022 has been further split into mdpH-1 and mdpH-2.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF90095.1"/>
        <property type="status" value="ALT_SEQ"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AACD01000005">
        <property type="protein sequence ID" value="EAA66024.1"/>
        <property type="status" value="ALT_SEQ"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P9WEV8"/>
    <dbReference type="SMR" id="P9WEV8"/>
    <dbReference type="InParanoid" id="P9WEV8"/>
    <dbReference type="OrthoDB" id="3454835at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009799">
        <property type="entry name" value="EthD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07110">
        <property type="entry name" value="EthD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000437097" description="Decarboxylase">
        <location>
            <begin position="1"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="EthD" evidence="2">
        <location>
            <begin position="29"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P0DOB3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="20139316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="21351751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="23658706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="6">
        <source>
            <dbReference type="PubMed" id="32872591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="7">
        <source>
            <dbReference type="PubMed" id="20139316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="8"/>
    <evidence type="ECO:0000305" key="9">
        <source>
            <dbReference type="PubMed" id="20139316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="10">
        <source>
            <dbReference type="PubMed" id="22730213"/>
        </source>
    </evidence>
    <sequence length="161" mass="18773" checksum="ED12D0306528BFC7" modified="2020-10-07" version="1">MSTPNPPATNSTTSEDRLLCLTILGYRKQGMSEEAYRKHMIEHSAPLTKDLMIKYGILRWTVKCPDRSKIHNPTETRELMYEIMDPQMANIADYDCFSQVVFRNFEDYKKIKDDPWYKEHLVGDHENFADTKRSKMTIGWITQFIDRGVVTEGFEGFPGPK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1997-11-01" modified="2026-01-28" version="140" xmlns="https://uniprot.org/uniprot">
    <accession>Q00667</accession>
    <accession>C8VKJ8</accession>
    <accession>Q5BC33</accession>
    <name>HGD_EMENI</name>
    <protein>
        <recommendedName>
            <fullName>Homogentisate 1,2-dioxygenase</fullName>
            <ecNumber evidence="2">1.13.11.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Homogentisate oxygenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Homogentisic acid oxidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Homogentisicase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">hmgA</name>
        <name type="ORF">AN1897</name>
    </gene>
    <organism>
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1995" name="J. Biol. Chem." volume="270" first="21199" last="21205">
            <title>Molecular characterization of a gene encoding a homogentisate dioxygenase from Aspergillus nidulans and identification of its human and plant homologues.</title>
            <authorList>
                <person name="Fernandez-Canon J.M."/>
                <person name="Penalva M.A."/>
            </authorList>
            <dbReference type="PubMed" id="7673153"/>
            <dbReference type="DOI" id="10.1074/jbc.270.36.21199"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>INDUCTION</scope>
        <source>
            <strain>biA1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>homogentisate + O2 = 4-maleylacetoacetate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15449"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16169"/>
            <dbReference type="ChEBI" id="CHEBI:17105"/>
            <dbReference type="EC" id="1.13.11.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text>Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 4/6.</text>
    </comment>
    <comment type="induction">
        <text evidence="2">During growth with phenylacetate and phenylalanine.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the homogentisate dioxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.5" evidence="2"/>
    <dbReference type="EMBL" id="U30797">
        <property type="protein sequence ID" value="AAC49071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AJ001836">
        <property type="protein sequence ID" value="CAA05042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AACD01000029">
        <property type="protein sequence ID" value="EAA65062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF85779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="A57435">
        <property type="entry name" value="A57435"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_659501.1">
        <property type="nucleotide sequence ID" value="XM_654409.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q00667"/>
    <dbReference type="SMR" id="Q00667"/>
    <dbReference type="STRING" id="227321.Q00667"/>
    <dbReference type="EnsemblFungi" id="CBF85779">
        <property type="protein sequence ID" value="CBF85779"/>
        <property type="gene ID" value="ANIA_01897"/>
    </dbReference>
    <dbReference type="GeneID" id="2874820"/>
    <dbReference type="KEGG" id="ani:ANIA_01897"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN1897"/>
    <dbReference type="eggNOG" id="KOG1417">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027174_0_0_1"/>
    <dbReference type="InParanoid" id="Q00667"/>
    <dbReference type="OMA" id="MLPHGPD"/>
    <dbReference type="OrthoDB" id="1689029at2759"/>
    <dbReference type="BioCyc" id="MetaCyc:MONOMER-12040"/>
    <dbReference type="BRENDA" id="1.13.11.5">
        <property type="organism ID" value="517"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00139">
        <property type="reaction ID" value="UER00339"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004411">
        <property type="term" value="F:homogentisate 1,2-dioxygenase activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006572">
        <property type="term" value="P:L-tyrosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07000">
        <property type="entry name" value="cupin_HGO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000053">
        <property type="entry name" value="Homogentisate 1,2-dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046451">
        <property type="entry name" value="HgmA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046452">
        <property type="entry name" value="HgmA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005708">
        <property type="entry name" value="Homogentis_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01015">
        <property type="entry name" value="hmgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11056">
        <property type="entry name" value="HOMOGENTISATE 1,2-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11056:SF0">
        <property type="entry name" value="HOMOGENTISATE 1,2-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04209">
        <property type="entry name" value="HgmA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20510">
        <property type="entry name" value="HgmA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0223">Dioxygenase</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-0585">Phenylalanine catabolism</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0828">Tyrosine catabolism</keyword>
    <feature type="chain" id="PRO_0000220245" description="Homogentisate 1,2-dioxygenase">
        <location>
            <begin position="1"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="340"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="346"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="377"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="7673153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="448" mass="50168" checksum="4AE6414823A04C0D" modified="1996-11-01" version="1">MPVTEFSFKDPYTYQNGFDSYHESEAIEGALPVGHNSPQKAPYGLYAEKLSGTAFTAPRHENKQTWVYRILPAAAHENFVEEDASSYHTLSDAKKLQHIPNQLRWDPFDLDETVDWVHGLHLVAGSGDPTVKQGLGILLYAAGKDMGKEAFYSADGDFLIVAQHGVLDIQTELGRLLVRPNEICVIPRGVRYRVTLPDGPVRGYICELYQGHYQLPELGPIGSNGLANARDFQAPVAAFDDEEGPTEYRLYSKFNNHLFSARQDHTPFDIVAWHGNYYPYKYDLGRFNTMGSVSFDHPDPSIYTVLTGPSDHVGTAIADFVIFPPRWLVAEKTFRPPWYHRNTMSEFMGLITGNYDAKTGGGFQPAGASLHNIMSAHGPDMHAFEGASNADLKPTKIGDGSMAFMFESSLMVGVSEWGLKTCQKVQEEYNEHSWQPLKRHFKDPRKAQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1997-11-01" modified="2025-04-09" version="121" xmlns="https://uniprot.org/uniprot">
    <accession>Q12608</accession>
    <accession>C8VDU8</accession>
    <accession>Q5AV56</accession>
    <name>STCB_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cytochrome P450 monooxygenase stcB</fullName>
            <ecNumber evidence="14">1.14.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Cytochrome P450 62</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Sterigmatocystin biosynthesis cluster protein B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">stcB</name>
        <name type="synonym">cyp62</name>
        <name type="ORF">AN7824</name>
    </gene>
    <organism>
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1996" name="Proc. Natl. Acad. Sci. U.S.A." volume="93" first="1418" last="1422">
            <title>Twenty-five coregulated transcripts define a sterigmatocystin gene cluster in Aspergillus nidulans.</title>
            <authorList>
                <person name="Brown D.W."/>
                <person name="Yu J.-H."/>
                <person name="Kelkar H.S."/>
                <person name="Fernandes M."/>
                <person name="Nesbitt T.C."/>
                <person name="Keller N.P."/>
                <person name="Adams T.H."/>
                <person name="Leonard T.J."/>
            </authorList>
            <dbReference type="PubMed" id="8643646"/>
            <dbReference type="DOI" id="10.1073/pnas.93.4.1418"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <scope>INDUCTION</scope>
        <scope>FUNCTION</scope>
        <scope>PATHWAY</scope>
        <source>
            <strain>FGSC 26</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="1994" name="Appl. Environ. Microbiol." volume="60" first="1444" last="1450">
            <title>Aspergillus nidulans verA is required for production of the mycotoxin sterigmatocystin.</title>
            <authorList>
                <person name="Keller N.P."/>
                <person name="Kantz N.J."/>
                <person name="Adams T.H."/>
            </authorList>
            <dbReference type="PubMed" id="8017929"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="1995" name="Appl. Environ. Microbiol." volume="61" first="3628" last="3632">
            <title>StcS, a putative P-450 monooxygenase, is required for the conversion of versicolorin A to sterigmatocystin in Aspergillus nidulans.</title>
            <authorList>
                <person name="Keller N.P."/>
                <person name="Segner S."/>
                <person name="Bhatnagar D."/>
                <person name="Adams T.H."/>
            </authorList>
            <dbReference type="PubMed" id="7486998"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="1995" name="J. Bacteriol." volume="177" first="4792" last="4800">
            <title>Sterigmatocystin biosynthesis in Aspergillus nidulans requires a novel type I polyketide synthase.</title>
            <authorList>
                <person name="Yu J.-H."/>
                <person name="Leonard T.J."/>
            </authorList>
            <dbReference type="PubMed" id="7642507"/>
        </citation>
        <scope>FUNCTION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="7">
        <citation type="journal article" date="1996" name="Appl. Environ. Microbiol." volume="62" first="4296" last="4298">
            <title>Aspergillus nidulans stcP encodes an O-methyltransferase that is required for sterigmatocystin biosynthesis.</title>
            <authorList>
                <person name="Kelkar H.S."/>
                <person name="Keller N.P."/>
                <person name="Adams T.H."/>
            </authorList>
            <dbReference type="PubMed" id="8900026"/>
            <dbReference type="DOI" id="10.1128/aem.62.11.4296-4298.1996"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="8">
        <citation type="journal article" date="1996" name="Proc. Natl. Acad. Sci. U.S.A." volume="93" first="14873" last="14877">
            <title>Aspergillus has distinct fatty acid synthases for primary and secondary metabolism.</title>
            <authorList>
                <person name="Brown D.W."/>
                <person name="Adams T.H."/>
                <person name="Keller N.P."/>
            </authorList>
            <dbReference type="PubMed" id="8962148"/>
            <dbReference type="DOI" id="10.1073/pnas.93.25.14873"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="9">
        <citation type="journal article" date="1997" name="J. Biol. Chem." volume="272" first="1589" last="1594">
            <title>Aspergillus nidulans stcL encodes a putative cytochrome P-450 monooxygenase required for bisfuran desaturation during aflatoxin/sterigmatocystin biosynthesis.</title>
            <authorList>
                <person name="Kelkar H.S."/>
                <person name="Skloss T.W."/>
                <person name="Haw J.F."/>
                <person name="Keller N.P."/>
                <person name="Adams T.H."/>
            </authorList>
            <dbReference type="PubMed" id="8999832"/>
            <dbReference type="DOI" id="10.1074/jbc.272.3.1589"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="10">
        <citation type="journal article" date="1998" name="Mol. Microbiol." volume="28" first="1355" last="1365">
            <title>Sequence-specific binding by Aspergillus nidulans aflR, a C6 zinc cluster protein regulating mycotoxin biosynthesis.</title>
            <authorList>
                <person name="Fernandes M."/>
                <person name="Keller N.P."/>
                <person name="Adams T.H."/>
            </authorList>
            <dbReference type="PubMed" id="9680223"/>
            <dbReference type="DOI" id="10.1046/j.1365-2958.1998.00907.x"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="11">
        <citation type="journal article" date="2000" name="Appl. Environ. Microbiol." volume="66" first="359" last="362">
            <title>Requirement of monooxygenase-mediated steps for sterigmatocystin biosynthesis by Aspergillus nidulans.</title>
            <authorList>
                <person name="Keller N.P."/>
                <person name="Watanabe C.M."/>
                <person name="Kelkar H.S."/>
                <person name="Adams T.H."/>
                <person name="Townsend C.A."/>
            </authorList>
            <dbReference type="PubMed" id="10618248"/>
            <dbReference type="DOI" id="10.1128/aem.66.1.359-362.2000"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>PATHWAY</scope>
    </reference>
    <reference key="12">
        <citation type="journal article" date="2012" name="Metabolites" volume="2" first="100" last="133">
            <title>Genetics of polyketide metabolism in Aspergillus nidulans.</title>
            <authorList>
                <person name="Klejnstrup M.L."/>
                <person name="Frandsen R.J."/>
                <person name="Holm D.K."/>
                <person name="Nielsen M.T."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen J.B."/>
            </authorList>
            <dbReference type="PubMed" id="24957370"/>
            <dbReference type="DOI" id="10.3390/metabo2010100"/>
        </citation>
        <scope>REVIEW ON STERIGMATOCYSTIN BIOSYNTHESIS</scope>
    </reference>
    <comment type="function">
        <text evidence="2 3 4 6 7 8 9 11 15">Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of sterigmatocystin (ST), a polyketide-derived furanocoumarin which is part of the most toxic and carcinogenic compounds among the known mycotoxins (PubMed:10618248, PubMed:8643646). The first step in the biosynthesis of sterigmatocystin is the production of hexanoate by the fatty acid synthase (FAS) units stcJ and stcK (PubMed:8962148). The polyketide backbone is assembled by the non-reducing polyketide synthase stcA by condensation of the starter hexanoyl-CoA and 7 malonyl-CoA extender units followed by cyclization and release of norsolorinic acid (By similarity). Norsolorinic acid is the first stable intermediate in the biosynthesis of sterigmatocystin and is converted into averantin (AVN) by the ketoreductase stcE which reduces the hexanoate ketone to an alcohol (Probable) (PubMed:8643646). Averantin is then oxidized into 5'-hydroxyaverantin (HAVN) by the cytochrome P450 monooxygenase stcF (PubMed:10618248). 5'-hydroxyaverantin is further converted to 5'-oxyaverantin (OAVN) by the 5'-hydroxyaverantin dehydrogenase stcG (PubMed:24957370). The next step is the conversion of OAVN into averufin (AVF) which is catalyzed by a yet to be identified enzyme (PubMed:24957370). The cytochrome P450 monooxygenase stcB and the flavin-binding monooxygenase stcW are both required for the conversion of averufin to 1-hydroxyversicolorone (PubMed:10618248). The esterase stcI probably catalyzes the formation of versiconal hemiacetal acetate from 1-hydroxyversicolorone (PubMed:24957370). The oxydoreductase stcN then probably catalyzes the biosynthetic step from versiconal to versicolorin B (VERB) (PubMed:24957370). The next step is performed by the versicolorin B desaturase stcL to produce versicolorin A (VERA) (PubMed:8999832). The ketoreductase stcU and the cytochrome P450 monooxygenase stcS are involved in the conversion of versicolorin A to demethylsterigmatocystin (PubMed:7486998). The Baeyer-Villiger oxidas stcQ and the reductase stcR might be involved in the biosynthetic step from versicolorin A to demethylsterigmatocystin (PubMed:24957370). The final step in the biosynthesis of sterigmatocystin is the methylation of demethylsterigmatocystin catalyzed by the methyltransferase stcP (PubMed:8900026).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 6">Mycotoxin biosynthesis; sterigmatocystin biosynthesis.</text>
    </comment>
    <comment type="induction">
        <text evidence="5 6 10">The genes forming the sterigmatocystin biosynthesis cluster are co-regulated and induced on oatmeal porridge or the fungal isolates were grown either on oatmeal porridge or in YEC medium (0.2% yeast extract, 5.0% corn steep liquor) (PubMed:8017929, PubMed:8643646). Expression is positively regulated by the cluster-specific transcription factor aflR that binds the palindromic sequence 5'-TCG(N5)CGA-3'found in the promoter (PubMed:9680223).</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="3">Impairs the production of sterigmatocystin and leads to the accumulation of averufin.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="sequence caution" evidence="13">
        <conflict type="erroneous gene model prediction">
            <sequence resource="EMBL-CDS" id="AAC49192" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EC" id="1.14.-.-" evidence="14"/>
    <dbReference type="EMBL" id="U34740">
        <property type="protein sequence ID" value="AAC49192.1"/>
        <property type="status" value="ALT_SEQ"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AACD01000132">
        <property type="protein sequence ID" value="EAA61612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF80182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_681093.1">
        <property type="nucleotide sequence ID" value="XM_676001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q12608"/>
    <dbReference type="SMR" id="Q12608"/>
    <dbReference type="STRING" id="227321.Q12608"/>
    <dbReference type="EnsemblFungi" id="CBF80182">
        <property type="protein sequence ID" value="CBF80182"/>
        <property type="gene ID" value="ANIA_07824"/>
    </dbReference>
    <dbReference type="KEGG" id="ani:ANIA_07824"/>
    <dbReference type="eggNOG" id="KOG0157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_14_2_1"/>
    <dbReference type="InParanoid" id="Q12608"/>
    <dbReference type="OMA" id="WTLMANE"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="UniPathway" id="UPA00377"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045461">
        <property type="term" value="P:sterigmatocystin biosynthetic process"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd11059">
        <property type="entry name" value="CYP_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000093">
        <property type="entry name" value="Cytochrome P450 monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF96">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE STCB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-0349">Heme</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0503">Monooxygenase</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0843">Virulence</keyword>
    <feature type="chain" id="PRO_0000052051" description="Cytochrome P450 monooxygenase stcB">
        <location>
            <begin position="1"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="1">
        <location>
            <position position="461"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P04798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="Q12053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="10618248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="7486998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="8017929"/>
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    </evidence>
    <evidence type="ECO:0000269" key="6">
        <source>
            <dbReference type="PubMed" id="8643646"/>
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    </evidence>
    <evidence type="ECO:0000269" key="7">
        <source>
            <dbReference type="PubMed" id="8900026"/>
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    </evidence>
    <evidence type="ECO:0000269" key="8">
        <source>
            <dbReference type="PubMed" id="8962148"/>
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    </evidence>
    <evidence type="ECO:0000269" key="9">
        <source>
            <dbReference type="PubMed" id="8999832"/>
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    </evidence>
    <evidence type="ECO:0000269" key="10">
        <source>
            <dbReference type="PubMed" id="9680223"/>
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    </evidence>
    <evidence type="ECO:0000303" key="11">
        <source>
            <dbReference type="PubMed" id="24957370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="12">
        <source>
            <dbReference type="PubMed" id="8643646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="13"/>
    <evidence type="ECO:0000305" key="14">
        <source>
            <dbReference type="PubMed" id="10618248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="15">
        <source>
            <dbReference type="PubMed" id="8643646"/>
        </source>
    </evidence>
    <sequence length="517" mass="57140" checksum="7C1E1A5C92F5D102" modified="2009-05-26" version="2">MISQICNEVIGLVPKKEEPGWLSVTGHPGAVYCENSISSGPEATGADVSQAIRIAYFTPLKHIPGPWYASLTGLRLSWSVFANNRIHYVHSLHQKYGPIVRIGPQEIDVADPVAGREIHRMGSGFMKAPFYELLSPGPVDNIFNFRDPKLHAARRKLYARGFTLQSLRNEWEPKVRDIIKLTVEKIKCDAVKGEAEIMGWWTLMANEIVCQLTFGGGAGIVAKGVKEPFVLMLERRMGDLAHLLKHFAPPGYYLGRALAWFIPPLQDIFYSQERMFAAGGDVVSRAREAKKAQAEPRNLFNKALEAGNLTDTDIITDAGALLLAGSDPTAISLTFLLWCVLSRPEVQKQVEAEVATLEGELTDEACERLPILNAVIDESLRLYGAAPGCMPRSPPSGGVTIGGYFIPDDTIVATQNWSLQRNPSIWDDADTFDHTRWLSNSRITDQAKLAFNPFGYGARQCLGIHLGRMEMRLAAAMFFRECVGARLGRSVTDESMHVVDSFIAGVPRDRRCAITLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="102" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AR67</accession>
    <accession>C8VJS1</accession>
    <name>Q5AR67_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_09213</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF82311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_682482.1">
        <property type="nucleotide sequence ID" value="XM_677390.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AR67"/>
    <dbReference type="GeneID" id="2867960"/>
    <dbReference type="KEGG" id="ani:ANIA_09213"/>
    <dbReference type="eggNOG" id="ENOG502SMB5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_318601_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AR67"/>
    <dbReference type="OMA" id="DDWTWRY"/>
    <dbReference type="OrthoDB" id="2119228at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd01833">
        <property type="entry name" value="XynB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051532">
        <property type="entry name" value="Ester_Hydrolysis_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30383:SF19">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30383">
        <property type="entry name" value="THIOESTERASE 1/PROTEASE 1/LYSOPHOSPHOLIPASE L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="1">
        <location>
            <begin position="697"/>
            <end position="788"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF82311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="847" mass="93888" checksum="E4296F2DEDBEA3CF" modified="2005-04-26" version="1">MHAEAIEMLNSHEAIPVDPSNISAIETHSHQKRIVHALGLLGVQILSRLGAEALQSVIGELIEFFTTDDIIWTSRDNCRAYFSTQGGGNEEFRTYAKDHRQATAVDKKNVGWINPESTAPPVHFFEGDPAIGLYSVQFTATDKVAWSGIPNTEKCKIEGLCNPQYIFYHKGYRIVLNTWESQGRVSACQYSKGEDCKGLCASGVKDQFTSGGVKWGGDCAIPCIDDVPEGFKKVQNEEARFMVVGDSISHGMEDDWTWRYRLSQWMEHNGYTHHFVGPWTGTRGMDPISISQPRAPLLPDEEPREDYTGKSLGDYAKGVSQSFRDKGHASFWGRQVAQSKEQFKAWVSEYNPDYLLILLGFNDLGWWVNGPEALVGDMANLINDARKAKSDIKLLVGNVVDRTFIPGRQDLVDETAQYNKLLKESMKDWYREGSPISYVDVNSNYNCRPGGCPDGHDGLHPNALGEYHIAQSFARVLQSDFGYMGIEFRVPETVDSRPVSTPANVRSNSYPEGLWAVWDRVENARGYEVRWRLKGATSWWSEGAVYPVTNCAWQPWVINGQTWEFQVRTMGDNTVRSGWSALQSVTANVKTAPGPSNIIVEPRGNDLVVRWDAVTDYNVDRYGVMLYDRDKEDELMDVKAAKGTSLEITGLNSGHRYGVWVASYVGMVGSLSRNGIQAGGLPSVAREVIIGRGTPAPPAGLRVENLDATTVRLQWDKVSSATGYSVHVRSIIDNTAFRVDGTTTQTSYEVAWLFPGNWNFEFCISAYNGNLESAPVSCIIPPVCCGYEKRDLVATEYPKAENNSAFSNSISSFGGMSVGSLFTTFQQSIGLALDTASDHSLAIPGEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ARH6</accession>
    <accession>C8VKA0</accession>
    <name>Q5ARH6_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7357 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_09104</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF82543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_682373.1">
        <property type="nucleotide sequence ID" value="XM_677281.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ARH6"/>
    <dbReference type="STRING" id="227321.Q5ARH6"/>
    <dbReference type="GeneID" id="2867974"/>
    <dbReference type="KEGG" id="ani:ANIA_09104"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN9104"/>
    <dbReference type="eggNOG" id="ENOG502SF1H">
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        <property type="entry name" value="ZCCHC10 PROTEIN"/>
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    <dbReference type="PANTHER" id="PTHR13491:SF0">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 10"/>
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    <proteinExistence type="predicted"/>
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    </feature>
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        </location>
    </feature>
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            <begin position="312"/>
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        </location>
    </feature>
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            <begin position="937"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="997"/>
            <end position="1006"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF82543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="1006" mass="112198" checksum="C119A7DFE6CA3BC2" modified="2005-04-26" version="1">MRLHLTIQRHGLPVTRILWTTSPPSLFGHNHPNPSSISPASSSAVTSSRMPNALYGNGGYTIAQLLEDVNEVIPLETEPRLFEDETSGQWGLEDYVVEVGGSECLHFMEIEGILRDGDEVLIRALQIFDLKARQISGRHQISADGRHLIDGVPFGKPFLKRLTSSRPAIAIPPRKKRRTALALWGNGSAYDEEDSDWAPSVPQHAGTGKELSLLKPESEAGKTDRDMDEYEDAYQDDYEDYHEPNEDGDGTVIRHDMDKTSKGIESEDDDDVSSPEIGDLSEEIQDLKRDMELSGLLPESRISDVKAHCSYSLRSRPSNSQTEPRKSSLSRRSFGRPADGDVSRRESKRVSFDKSKQELGTAKSQSLVPRAGSTSEEPDDSVSSDSDSDSSVSGSSASESSEEDSSSDDAESESESESESTSATTSDSSLDSESDSSSESSASESESEPEDVGKSKPVLKPTHEAKPPGTGSERTRKCNRRAKMRRRLTKLKQMGFLDENANFDALREWDSKNRDSDFSFTKPDLESRKAQEQEEFEAKRRKLLRDLESGGVDVSFVSEKENLTPNSIGPDTTELPEDQEEHYETANDATPANAELSKRRSLDVASTRRLLFGSLGVKNPRSKEEEEATRKRLVGKVRESILHPTERQQEEQGFAETHEGEPHVDWHEKLVLGATECVYDDIELSAPPFPFEQRWDNEAGDEIRRRRGRNKKRKRRQQLQVYDEGAYGNEDYYDGEDQQLNYDDSEQPEIESENKEGMDEMTTRTTAEPEDDLPDLPDDPSSLPDLVINDLKPGTVVAFKQLDVSKATNWQPTVSDYRVAVVSEVFDDNILNMQLAKPYRRQPRDADAEEGPFSYSGFEMPGMEDDEGVDDGFREVPFDDLIGPKVLRAAPSTDGREKDTANIRLELTRPSFPADEVPPAQEPSQSANDAPTAINGHENQLVHTSSQREISYPSGKRVSTPDPAPLEDSFARSPRFEGFDDSMETTNGTDTVNSSYIRDENPGEHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ARJ1</accession>
    <accession>C8VH57</accession>
    <name>Q5ARJ1_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_09089</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF82572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_677266.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="2867952"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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        <property type="component" value="Chromosome VI"/>
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        <location>
            <begin position="208"/>
            <end position="246"/>
        </location>
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            <begin position="383"/>
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            <begin position="410"/>
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    </feature>
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        <location>
            <begin position="478"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CBF82572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="565" mass="62106" checksum="1F4B44CE8555C4D8" modified="2005-04-26" version="1">MFCDPGPRDVPLLLPDCIYTDITSDFLESPYLHNPAFFGSAAYYQPQGNLGYLPVLTTFIPSLPADSPFRVSIHSWEPPHSLRGWTVRRSSSSCRGSVFPPRTNWPHVIDLSSHVDKNGNQDTLRFPPFHQEILEQRHWDAGDLHGRIRVVVAEGFARPHRNPPFERVKEIIAFAFQHAPLNVLEYSSIAWPNTSMWSKEPRLFKYNAGSGVSDPKEAEDSHAHSPAARHDETRPPVAPITGQIGNPPALNFWRNRSYQGPVPQWQGNYREPRWAPPETVFADPFIDPYVLDPAARHRGARQSWEDISMPDYVSNSSGSRAISSMTGISYEHSKHPSLVAPIGDDAYSQLIQALSPTKQPTCSTQPPTTASATAAIPMGTKLSAAAEARSASHRKSGNSRASANILEDMSCSNSRDVSGSTTAASNTMPPDPSAEQGAAAKLHASPSGPIKSRKEGISLENKENEAEKACRDSDKARQTPSKLNVLTNSGVETPTDGRKRRSVNSSRDDCLIINKKEPVLLSPTLLSPTQDLSRIKDSVHKDGFDRFLDSQSTLVSPTAEVDEVE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2010-06-15" modified="2026-01-28" version="102" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ARP5</accession>
    <accession>C8VKR4</accession>
    <accession>Q1HFQ4</accession>
    <name>AGALG_EMENI</name>
    <protein>
        <recommendedName>
            <fullName>Probable alpha-galactosidase G</fullName>
            <ecNumber>3.2.1.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Melibiase G</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">aglG</name>
        <name type="ORF">AN9035</name>
    </gene>
    <organism>
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="11417" last="11422">
            <title>Development and application of a suite of polysaccharide-degrading enzymes for analyzing plant cell walls.</title>
            <authorList>
                <person name="Bauer S."/>
                <person name="Vasu P."/>
                <person name="Persson S."/>
                <person name="Mort A.J."/>
                <person name="Somerville C.R."/>
            </authorList>
            <dbReference type="PubMed" id="16844780"/>
            <dbReference type="DOI" id="10.1073/pnas.0604632103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Hydrolyzes a variety of simple alpha-D-galactoside as well as more complex molecules such as oligosaccharides and polysaccharides (By similarity). Not active on paranitrophenyl-alpha-galactoside and raffinose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.</text>
            <dbReference type="EC" id="3.2.1.22"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyl hydrolase 36 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.22"/>
    <dbReference type="EMBL" id="DQ490520">
        <property type="protein sequence ID" value="ABF50896.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AACD01000168">
        <property type="protein sequence ID" value="EAA64367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF84419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_682304.1">
        <property type="nucleotide sequence ID" value="XM_677212.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ARP5"/>
    <dbReference type="SMR" id="Q5ARP5"/>
    <dbReference type="STRING" id="227321.Q5ARP5"/>
    <dbReference type="CAZy" id="GH36">
        <property type="family name" value="Glycoside Hydrolase Family 36"/>
    </dbReference>
    <dbReference type="GlyCosmos" id="Q5ARP5">
        <property type="glycosylation" value="5 sites, No reported glycans"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CBF84419">
        <property type="protein sequence ID" value="CBF84419"/>
        <property type="gene ID" value="ANIA_09035"/>
    </dbReference>
    <dbReference type="KEGG" id="ani:ANIA_09035"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN9035"/>
    <dbReference type="eggNOG" id="ENOG502QWG1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009640_2_1_1"/>
    <dbReference type="InParanoid" id="Q5ARP5"/>
    <dbReference type="OMA" id="IHPARVM"/>
    <dbReference type="OrthoDB" id="5795902at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004557">
        <property type="term" value="F:alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14791">
        <property type="entry name" value="GH36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000118">
        <property type="entry name" value="Alpha-galactosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.60">
        <property type="entry name" value="alpha-galactosidase from lactobacil brevis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038417">
        <property type="entry name" value="Alpga-gal_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050985">
        <property type="entry name" value="Alpha-glycosidase_related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002252">
        <property type="entry name" value="Glyco_hydro_36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031705">
        <property type="entry name" value="Glyco_hydro_36_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031704">
        <property type="entry name" value="Glyco_hydro_36_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43053:SF3">
        <property type="entry name" value="ALPHA-GALACTOSIDASE C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43053">
        <property type="entry name" value="GLYCOSIDASE FAMILY 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16874">
        <property type="entry name" value="Glyco_hydro_36C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16875">
        <property type="entry name" value="Glyco_hydro_36N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02065">
        <property type="entry name" value="Melibiase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005536">
        <property type="entry name" value="Agal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00743">
        <property type="entry name" value="GLHYDRLASE36"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0326">Glycosidase</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-0624">Polysaccharide degradation</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <feature type="chain" id="PRO_0000395069" description="Probable alpha-galactosidase G">
        <location>
            <begin position="1"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="485"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="547"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="23"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="456"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="657"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="673"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="Q9ALJ4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3"/>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="726" mass="80682" checksum="5923C95FB42AA7C1" modified="2005-04-26" version="1">MTNSKARYVLEPVQVTGTTFALNGTTLSYQFHVDEPSADLRSDHFGGSISGPIPVDPEPIVDGWTGMPDRVRREFPDQGRGDFRVPAFRIRQAEGHTVSAFRYREHEIVPGKEVSASGLPGVFGDAHDATTLIVRLVDPYSDLAAELKYTVFPKYDTVVRSASITNKSNSDVTIESLASLSVDFPFDELEMIGLRGDWAREAHRLRRKVDYGVQSFGSTTGFSSHLHNPFVALVHPSTTESQGEAWGFSLIYSGSFTINVEKSSQGLTRVSIGPSQLSWTLKPGETFDSPECVAVYSSTGIGGMSRSLHGLYRKHLMKSKFATEDRPVLLNSWEGLYFHIDQDRMYRLAQEAAALGVKLLVMDDGWFGDEHPRTSDDAGLGDWIPNPARFPDGLTPLVNRITALKVANSQRNMRFGIWVEPEMVNPRSTLYQQHPDWVLHAGNYPRTEQRNQLVLNMSLPEVQEFIISAMSEILNAADITYVKWDHNRGLAETPSPCANHAYMLGAYRVFDVLTTRFPNVIWEGCASGGGRFDPGILQYFPQVWTSDDSDAVERIFIQFGTSLAYPASAMGGHISSVPNHQTGRTTPLTFRAHVAMMCGSFGLELDPAHLTDSERRDIPGLIALAEKISPIVVKGDLWRLALPEDSNWPAALFLSENRTQGVLFFFQLAPMVNHSLPRVRLQGLEDGALYRVDGEGPYSGSMLMNLGLQYSFRGDYGSRLAFIERE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="105" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ARS6</accession>
    <accession>C8VKZ7</accession>
    <name>Q5ARS6_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Xenobiotic compound monooxygenase, DszA family, putative (AFU_orthologue AFUA_1G17580)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ANIA_09004</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the NtaA/SnaA/DszA monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF84478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_682273.1">
        <property type="nucleotide sequence ID" value="XM_677181.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ARS6"/>
    <dbReference type="GeneID" id="2868264"/>
    <dbReference type="KEGG" id="ani:ANIA_09004"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN9004"/>
    <dbReference type="eggNOG" id="ENOG502QSR6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022256_0_0_1"/>
    <dbReference type="InParanoid" id="Q5ARS6"/>
    <dbReference type="OMA" id="VFMSGWM"/>
    <dbReference type="OrthoDB" id="5561043at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="entry name" value="Luciferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051260">
        <property type="entry name" value="Diverse_substr_monoxygenases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016215">
        <property type="entry name" value="NTA_MOA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03860">
        <property type="entry name" value="FMN_nitrolo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30011">
        <property type="entry name" value="ALKANESULFONATE MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30011:SF16">
        <property type="entry name" value="C2H2 FINGER DOMAIN TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000337">
        <property type="entry name" value="NTA_MOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="Bacterial luciferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="4 7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Luciferase-like" evidence="6">
        <location>
            <begin position="40"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00033748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBF84478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="482" mass="53443" checksum="C6CC7309CA4B547B" modified="2005-04-26" version="1">MSTQQQQPDRPRKSLILNAFVEMCSGHQSPGLWVHPEDESHRFNDIDHWIELAQLLESAKFHGIFIADVLGGYDVYKGPRNLEPAITSGAQWPVNEPLAVVPAMAAATKNIGFGVTVTTTYEQPYHLARRLSTVDHLTKGRIGWNIVTGYLDSAARNLGHAEQPQHDDRYAIAEEYIKVAYKLWESSWRSDAVILDKQRRVYTEPSRVREINHVGKYFNVPGPHLCQPSPQRTPVILQAGTSKAGKTFAAQHAEAIFVAGHSPSVVAKNVAEIRELAKSQYGRDPSSIKFLALLCPVLGKTEEEAKEKFAYYRSLGSIDGALALFGGWTGINLDVYGDDEELRSVPSNAIRSAVEGWSKATPEVPKWTKKTVGEHITVGGLGSTPVGTPEQVADEMERWVREADVDGFNLAYAIKPGSFKDIIDLLIPELRRRGLFHEDYAAPRATYRENLYGKPGQSGPPADHPAAKYRWHAGVEGHQIPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="133" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AS10</accession>
    <accession>C8VLJ2</accession>
    <name>Q5AS10_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">NADH-cytochrome b5 reductase 1</fullName>
            <ecNumber evidence="5">1.6.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="22">Microsomal cytochrome b reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="29" type="ORF">ANIA_08920</name>
    </gene>
    <organism evidence="29 30">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="30" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="30">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="30" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="30">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="19">NADH-dependent reductase for DPH3 and cytochrome b5. Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase, predominantly CBR1. By reducing DPH3, also involved in the formation of the tRNA wobble base modification mcm5s 2U (5-methoxycarbonylmethyl-2-thiouridine), mediated by the elongator complex. The cytochrome b5/NADH cytochrome b5 reductase electron transfer system supports the catalytic activity of several sterol biosynthetic enzymes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>2 Fe(3+)-[Dph3] + NADH = 2 Fe(2+)-[Dph3] + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:71231"/>
            <dbReference type="Rhea" id="RHEA-COMP:18002"/>
            <dbReference type="Rhea" id="RHEA-COMP:18003"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:83228"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:71232"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>2 Fe(III)-[cytochrome b5] + NADH = 2 Fe(II)-[cytochrome b5] + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46680"/>
            <dbReference type="Rhea" id="RHEA-COMP:10438"/>
            <dbReference type="Rhea" id="RHEA-COMP:10439"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 25">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="20">Monomer. Component of the 2-(3-amino-3-carboxypropyl)histidine synthase complex composed of DPH1, DPH2, DPH3 and a NADH-dependent reductase, predominantly CBR1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion outer membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="26">Belongs to the cytochrome b5 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.6.2.2" evidence="5"/>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF84656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_682189.1">
        <property type="nucleotide sequence ID" value="XM_677097.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AS10"/>
    <dbReference type="STRING" id="227321.Q5AS10"/>
    <dbReference type="GeneID" id="2868237"/>
    <dbReference type="KEGG" id="ani:ANIA_08920"/>
    <dbReference type="eggNOG" id="KOG0534">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0537">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003827_0_1_1"/>
    <dbReference type="InParanoid" id="Q5AS10"/>
    <dbReference type="OMA" id="KGAMQYS"/>
    <dbReference type="OrthoDB" id="260519at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090524">
        <property type="term" value="F:cytochrome-b5 reductase activity, acting on NADH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06183">
        <property type="entry name" value="cyt_b5_reduct_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000002">
        <property type="entry name" value="Cytochrome b5 type B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000032">
        <property type="entry name" value="NADH-cytochrome b5 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000019">
        <property type="entry name" value="NADH-cytochrome b5 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001834">
        <property type="entry name" value="CBR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370:SF178">
        <property type="entry name" value="CYTOCHROME-B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00406">
        <property type="entry name" value="CYTB5RDTASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 25" id="KW-0274">FAD</keyword>
    <keyword evidence="7 25" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 26" id="KW-0349">Heme</keyword>
    <keyword evidence="15 26" id="KW-0408">Iron</keyword>
    <keyword evidence="18 26" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 26" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="16" id="KW-0520">NAD</keyword>
    <keyword evidence="14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="30" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 26" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 26" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="27">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="28">
        <location>
            <begin position="233"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="binding site" evidence="25">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="25">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="25">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="25">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="25">
        <location>
            <position position="353"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00037104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00038836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00039438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00041901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00047682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00049138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="PIRSR" id="PIRSR601834-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="RuleBase" id="RU362121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="EMBL" id="CBF84656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="458" mass="50083" checksum="53BB4D6F77A2B626" modified="2005-04-26" version="1">MPSYTLEQVKAHCTPDDIWIILHNKVYEVTKYLEDHPGGSAVLIEVAGADATEAFEEIGHSDEAREQLEPYYIGDLPDQEQAESVEIYRPTFEQVSQSAVINTKKTSKSFSSLLSVLVKLGLTGAVGAATIAVFQKNWTPRQLLHALPALTTPIPLPRISGSGGSQFWSGVGIATITQLSLSFGLGVWVSTKLDVQQEFTHYPPRRPASSARLIRLPSTTRALAPRSPVLDPRQWRSFPLTSKKEVAPNVYRLVFALPKADDILGLPTGQHVALRATVDGKTVQRSYTPISNNTDRGHIELLIKVYPKGLLTNHLAQMEVGETIEMRGPKGAMKYSAQYAYRIGMIAGGTGITPMYQLIRAICEDESDNTQVSLLYANNGEADILLREELESFAGRFPHKFKMEGFVNGEMIAKHIGSPADDAKVLLCGPPPMVEAMKKTLAGMGWDMPGAIANGTDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="134" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AS68</accession>
    <accession>C8V9B6</accession>
    <name>Q5AS68_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Aspergillus nidulans myosin V homolog (Eurofung)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">ANIA_08862</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF77853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_682131.1">
        <property type="nucleotide sequence ID" value="XM_677039.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q5AS68">
        <property type="interactions" value="573"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5AS68"/>
    <dbReference type="GeneID" id="2868392"/>
    <dbReference type="KEGG" id="ani:ANIA_08862"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN8862"/>
    <dbReference type="eggNOG" id="KOG0160">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000192_3_1_1"/>
    <dbReference type="InParanoid" id="Q5AS68"/>
    <dbReference type="OMA" id="EIMFDDR"/>
    <dbReference type="OrthoDB" id="6108017at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031521">
        <property type="term" value="C:spitzenkorper"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030448">
        <property type="term" value="P:hyphal growth"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="CDD" id="cd15480">
        <property type="entry name" value="fMyo2p_CBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23767">
        <property type="entry name" value="IQCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01380">
        <property type="entry name" value="MYSc_Myo5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.820:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002710">
        <property type="entry name" value="Dilute_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046943">
        <property type="entry name" value="Fungal_Myo2/2A_CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036103">
        <property type="entry name" value="MYSc_Myo5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004009">
        <property type="entry name" value="SH3_Myosin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF706">
        <property type="entry name" value="DILUTE CLASS UNCONVENTIONAL MYOSIN, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01843">
        <property type="entry name" value="DIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM01132">
        <property type="entry name" value="DIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50084">
        <property type="entry name" value="Myosin S1 fragment, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51126">
        <property type="entry name" value="DILUTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51844">
        <property type="entry name" value="SH3_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="4 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 9" id="KW-0505">Motor protein</keyword>
    <keyword evidence="6 9" id="KW-0518">Myosin</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Myosin N-terminal SH3-like" evidence="13">
        <location>
            <begin position="6"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="Myosin motor" evidence="12">
        <location>
            <begin position="74"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="domain" description="Dilute" evidence="11">
        <location>
            <begin position="1231"/>
            <end position="1500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="9">
        <location>
            <begin position="655"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="915"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="1151"/>
            <end position="1178"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="168"/>
            <end position="175"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CBF77853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="1569" mass="179083" checksum="7844E9E722697750" modified="2005-04-26" version="1">MAHNYEVGTRAWQPDATEGWVASEVKEKLVDGDKVRLVFVLENGEPKEIETTQAELQVDNNPNLPPLMNPAMLEASEDLTNLSHLNEPAVLQAIKLRYAQKEIYTYSGIVLIATNPFARVDSLYVPQMVQVYAGKHRASQAPHLFAIAEEAFGDMLRDGKNQTIVVSGESGAGKTVSAKYIMRYFATRESSDQPGKYTTSRADAISETEEQILATNPVMEAFGNAKTTRNDNSSRFGKYIEIMFDDKTNIVGAKIRTYLLERSRLVFQPLKERNYHIFYQLVAGASDTEKQELGLTSVEDFDYLNQGGTPIIDGVDDKTEFIATKKSLGTIGVPETIQSEIFRVLAALLHLGNVKITATRTDSTLSPSEPSLSRACEILGIDANEFAKWIVKKQLITRGEKITSNLTQQQAIVVRDSVAKFIYSSLFDWLVDKINRGLATDEVLNKFKSFIGVLDIYGFEHFAKNSFEQFCINYANEKLQQEFNQHVFKLEQEEYVREQIDWTFIDFSDNQPCIDLIEAKLGILSLLDEESRLPMGSDEQFVTKLHHNFAADKQKFYKKPRFGKSAFTICHYAVDVTYESDGFIEKNRDTVPDEHMEILRNSSNNFVKEILDTAASVREKDSAAVSSKPVTAPGRKIGVAINRKPTLGGIFKSSLIELMSTINSTDVHYIRCIKPNEAKEAWVFEGPMVLNQLRACGVLETVRISTAGYPTRWTYEEFAIRYYMLCHSSQWTSEIKDMCHAILRKALGDATQQKHDKYQLGLSKIFFRAGMLAFLENLRTSRLNECAIMIQKNLRCKYYRRRYLEARLSVLATQSLVRGFLARQRAAEIRRIKAATTIQRVWRGQKERKRYNQIRDNVILLQSLSKGFLCRRNILNSIHGNAAKTIQRAFRSWRQLRAWRQYRRQVIIVQNLWRGKKARREYKVLREEARDLKQISYKLENKVVELTQYLESLKRENKSLNSQLENYETQLKSWRSRHNALENRSRELQAEANQAGITAARLTALEEEMSILQQNHADGQATIKRLQEEERISRDSIRSANQELEKLKQLNAEAESERTSLRQQVIDLEEQLEVAKRTLPLQALNGDQQNGGSVPPPANGLINLVSSKKTKPKRRSAGAERIDTDRFSGAYNPRPVSMAIPSALGRQNYSVAALSSGLDSVEAELETLLSEEDELNEEVAIGLIRNLKIPAPNSTPPPTEKEVLFPAYLINLVTSEMWNNGFVKESERFLANVMQSIQQEVMQHDGDDTISPGAFWLSNVHEMLSFVFLAEDWYEAQKTDNYEYDRLLEIVKHDLESLEFNIYHTWMKLLKKKLYKMIVPAIIESQSLPGFVTNETNRFLGKLLPSNNNPAYSMDNLLSLLNNAYKAMKAFYLEDSIITQTVTELLRLVGVTAFNDLLMRRNFLSWKRGLQINYNITRIEEWCKSHDMPEGTLQLEHLMQATKLLQLKKATLNDIEIIQDICWMLSPNQIQKLLNQYLVADYEQPINGEIMKAVASRVTEKSDVLLLTPVDMEDSGPYEIAEPRVITALETYTPSWLQTPRLKRLAEIVSAQAMAQQDKPENTENGVME</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="108" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ASV8</accession>
    <accession>C8VAE7</accession>
    <name>Q5ASV8_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alkaline phosphatase, putative (AFU_orthologue AFUA_6G08710)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ANIA_08622</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF78311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_681891.1">
        <property type="nucleotide sequence ID" value="XM_676799.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ASV8"/>
    <dbReference type="STRING" id="227321.Q5ASV8"/>
    <dbReference type="GeneID" id="2868515"/>
    <dbReference type="KEGG" id="ani:ANIA_08622"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN8622"/>
    <dbReference type="eggNOG" id="ENOG502QU5W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015982_0_0_1"/>
    <dbReference type="InParanoid" id="Q5ASV8"/>
    <dbReference type="OMA" id="RWDILGQ"/>
    <dbReference type="OrthoDB" id="9992270at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="CDD" id="cd07389">
        <property type="entry name" value="MPP_PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.70">
        <property type="entry name" value="PhoD-like phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.380">
        <property type="entry name" value="Purple acid phosphatase-like, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018946">
        <property type="entry name" value="PhoD-like_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038607">
        <property type="entry name" value="PhoD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032093">
        <property type="entry name" value="PhoD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052900">
        <property type="entry name" value="Phospholipid_Metab_Enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43606">
        <property type="entry name" value="PHOSPHATASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G08710)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43606:SF7">
        <property type="entry name" value="PHOSPHATASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G08710)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09423">
        <property type="entry name" value="PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16655">
        <property type="entry name" value="PhoD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010321231" evidence="1">
        <location>
            <begin position="22"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipase D N-terminal" evidence="3">
        <location>
            <begin position="70"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="PhoD-like phosphatase metallophosphatase" evidence="2">
        <location>
            <begin position="200"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBF78311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="641" mass="72098" checksum="7161BCFADCC8CA40" modified="2005-04-26" version="1">MVTTTALGLLSLLSLAAPSLASYSVNLNYRSPSLNKDHINLGIDTAKITRRSLVKRSEPPYAPSQLSFTHSVASGDPYADSVILWTRVAPSLNASSSEVPVSGDVPLYNHDNEKYAKASAHPICVEYRVFEDEEATSVVDQGRVFTSSDVDYTVKVEATGLEPFTTYWYQFNVCDSEKVSPLGRTKTAPAADQDLKEVKLAVHSCSNYRAFSATGPFCTSGYFNAYGNVARKDNVDYVVHLGDYIYEYENGVPGVDERAVVPPREIFSLYDYRTRLGQYRTDQDLVASHAKFPWIPVWDDHEIANNGYRDGFSGLRNTEDSFLNYGPQVSVDQRKMNAVRAYFEWMPIRQVDMDDGLRIWRSFQMGNLFDLIMIDTRNYDRSITDLSDNSEYIKLIHDDTGRSLMGPRQENWFYRQLSSSKDRGAKWRVIGNQLVFAHIQQKNEDGSLSFSGDAWTAYRANQNRTLKHMYENEIRNNINIAGDTHVNWVSDMIWEGTKPYNNVTGAGAVGVEFAGTAVSSTGLSTVSVADAESVAETYSINPELKWVEGYYRGYFELHLRQDEAEARYFGCPTVAERNSWELPLANWTVSHSESHLQRPLAGGSVEAGYFVNGNVKHSELAVNTETGKWEAVSFGKMFIRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ATE6</accession>
    <accession>C8VEE1</accession>
    <name>Q5ATE6_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ankyrin repeat protein (AFU_orthologue AFUA_7G06200)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_08434</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF80541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_681703.1">
        <property type="nucleotide sequence ID" value="XM_676611.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ATE6"/>
    <dbReference type="GeneID" id="2868653"/>
    <dbReference type="KEGG" id="ani:ANIA_08434"/>
    <dbReference type="eggNOG" id="KOG0502">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024883_0_0_1"/>
    <dbReference type="InParanoid" id="Q5ATE6"/>
    <dbReference type="OMA" id="MADNIFV"/>
    <dbReference type="OrthoDB" id="2142040at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34706:SF3">
        <property type="entry name" value="ANKYRIN REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_7G06200)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34706">
        <property type="entry name" value="SLR1338 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13857">
        <property type="entry name" value="Ank_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="32"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="65"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="104"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF80541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="495" mass="54261" checksum="7C9B9A4BCCB7B2B1" modified="2005-04-26" version="1">MTLHSASSDGTLTRAALQRYLVLVEIDALDDRGFTPLAVAIKNGHPSVVKLLLQNGASADKPVRDGRTPLYLAANAKQNRARIVQLLLSHDPRPDIDASSPEWNNETPLMVAITQGRDPEVVRLLVEAGASLTRTNDRGETAVALADQSTNPAIRDALSLGGQRGWAAALAQLLVSAILFALAYADKWPGVKEIIQNVIRSAYNQANPALPGSLPPAGTDIDDPHTVEEFKHNITNIIQKNGLDDFFPANDPYIQSVAEKAAAFRKDQVNPLANNVPFIMKAAAAALYQPVLYIDDSGSMAEDGRMERARELVTLITEVATKFVNVNTGVHLRFINKDDSTANNLSANEVRQRMSFTPQGWTELGTNLTKKILQPMVYDAIAQGVLERPFLILTITDGVPSKEQPGEFRKAIVRCKRELRDRGYQKEAVFFDLSQVGNDPGAIAFIESFEGDEATEDVLHRTAENTDRLFDELREAGDPSQLALWTIPCGMFLMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="105" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AU75</accession>
    <accession>C8V6W4</accession>
    <name>Q5AU75_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ANIA_08155</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF73993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_681424.1">
        <property type="nucleotide sequence ID" value="XM_676332.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AU75"/>
    <dbReference type="GeneID" id="2869137"/>
    <dbReference type="KEGG" id="ani:ANIA_08155"/>
    <dbReference type="eggNOG" id="ENOG502SVC9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_9_1_1"/>
    <dbReference type="InParanoid" id="Q5AU75"/>
    <dbReference type="OMA" id="WILPAYG"/>
    <dbReference type="OrthoDB" id="9876299at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051468">
        <property type="entry name" value="Fungal_SecMetab_SDRs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544:SF7">
        <property type="entry name" value="NADB-LER2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GDHRDH"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBF73993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="234" mass="25121" checksum="9D6350A4EE26A8D4" modified="2005-04-26" version="1">MSDSTVVLITGVARGIGQALAKAYLSRPNHTVLGTIRDPSAQSLSALSSHVPAQGSRLLLFTLESTTASHYADLVSSLKTAGITHLDLVIANAGVAYPAGTPASVDVEDVKNVFDVNALGTLRLFQALRGFLEVGSNNGRRVKWCPLPVFSALERKKKSVRLSLVQTEMGNKGAQKMGLKEAPNTVEEAITKTLAAKLNRDLRLMRGRRQIDSATREDTSGKFLNIIDGAEVPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="105" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AUY8</accession>
    <accession>C8V4J0</accession>
    <name>Q5AUY8_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SHSP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ANIA_07892</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF73469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_681161.1">
        <property type="nucleotide sequence ID" value="XM_676069.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AUY8"/>
    <dbReference type="FunCoup" id="Q5AUY8">
        <property type="interactions" value="1019"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5AUY8"/>
    <dbReference type="GeneID" id="2869184"/>
    <dbReference type="KEGG" id="ani:ANIA_07892"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN7892"/>
    <dbReference type="eggNOG" id="KOG0710">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046737_1_1_1"/>
    <dbReference type="InParanoid" id="Q5AUY8"/>
    <dbReference type="OMA" id="FRPFFRM"/>
    <dbReference type="OrthoDB" id="1431247at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd06464">
        <property type="entry name" value="ACD_sHsps-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031107">
        <property type="entry name" value="Small_HSP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11527">
        <property type="entry name" value="HEAT-SHOCK PROTEIN 20 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="SHSP" evidence="5">
        <location>
            <begin position="36"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="88"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="115"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBF73469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="184" mass="20839" checksum="33C4F0F0174903D0" modified="2005-04-26" version="1">MSLFTTTPSVSSFAPLFNLLDDYDNHLASRNWGHHTSVRSFSPRFDVRETSDTYHLDGEVPGVAQKDIDIEFTDPQTLVIKGRVERQYHSGNTDDTGKQRQVEDENESSSNEVAKTSEKQMTKSASSEKPRYWVSERSVGEFQRTFSFPSRVDQDRVRASLRDGILSVVVPKEAPPNAKKITIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AVT2</accession>
    <accession>C8VBU2</accession>
    <name>Q5AVT2_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glycoside hydrolase 131 catalytic N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_07598</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF79713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_680867.1">
        <property type="nucleotide sequence ID" value="XM_675775.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AVT2"/>
    <dbReference type="SMR" id="Q5AVT2"/>
    <dbReference type="STRING" id="227321.Q5AVT2"/>
    <dbReference type="CAZy" id="GH131">
        <property type="family name" value="Glycoside Hydrolase Family 131"/>
    </dbReference>
    <dbReference type="GeneID" id="2869756"/>
    <dbReference type="KEGG" id="ani:ANIA_07598"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN7598"/>
    <dbReference type="eggNOG" id="ENOG502QVJU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038296_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AVT2"/>
    <dbReference type="OMA" id="GQTMMRS"/>
    <dbReference type="OrthoDB" id="120072at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.1160:FF:000001">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041524">
        <property type="entry name" value="GH131_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34612">
        <property type="entry name" value="GH131_N DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34612:SF6">
        <property type="entry name" value="GLYCOSIDE HYDROLASE 131 CATALYTIC N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18271">
        <property type="entry name" value="GH131_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010241344" description="Glycoside hydrolase 131 catalytic N-terminal domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase 131 catalytic N-terminal" evidence="2">
        <location>
            <begin position="22"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF79713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="256" mass="28037" checksum="4A3C6D141D9E0C20" modified="2005-04-26" version="1">MKSTSILPLLSTLTPLASAATVWSGLFNESYTVADFDKWSWSSQIPPYQWYIHGSEETAHYLSLSSEYKNPNSTLDEAQGLKTTLDNTASWNGQTMMRTELIPQVESGVDIGSGKKYYHFSLSVDEDGLPNVELEHQIAFFESHFTELKYGGSSDTASSLTFYANSAAQWSTALEAGVWYNFAYGIDFDGGSVELYTSTGADDLELAVQAVSASASSNSQDWHVGVLRLDNGVDGGEESWYWSGVYVEDGEVTLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="126" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AVV8</accession>
    <accession>C8VBQ9</accession>
    <name>Q5AVV8_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">ANIA_07572</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 16">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 16">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF79652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_680841.1">
        <property type="nucleotide sequence ID" value="XM_675749.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q5AVV8">
        <property type="interactions" value="196"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5AVV8"/>
    <dbReference type="GeneID" id="2869551"/>
    <dbReference type="KEGG" id="ani:ANIA_07572"/>
    <dbReference type="eggNOG" id="KOG0605">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000709_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AVV8"/>
    <dbReference type="OMA" id="HNRRFVG"/>
    <dbReference type="OrthoDB" id="162894at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007346">
        <property type="term" value="P:regulation of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05611">
        <property type="entry name" value="STKc_Rim15_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000340">
        <property type="entry name" value="Serine threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000664">
        <property type="entry name" value="Serine threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000377">
        <property type="entry name" value="Serine threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.20:FF:000119">
        <property type="entry name" value="Serine threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000139">
        <property type="entry name" value="Serine threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050236">
        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE GREATWALL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="741"/>
            <end position="1174"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="13">
        <location>
            <begin position="1175"/>
            <end position="1292"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="12">
        <location>
            <begin position="1545"/>
            <end position="1659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="138"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="304"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="493"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="551"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="701"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="926"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="996"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1255"/>
            <end position="1274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1303"/>
            <end position="1513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1670"/>
            <end position="1694"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1734"/>
            <end position="1907"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1961"/>
            <end position="2041"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="152"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="329"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="502"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="554"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="604"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="680"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="929"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="952"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1032"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1259"/>
            <end position="1269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1303"/>
            <end position="1330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1348"/>
            <end position="1360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1361"/>
            <end position="1384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1400"/>
            <end position="1414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1415"/>
            <end position="1439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1462"/>
            <end position="1484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1678"/>
            <end position="1693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1750"/>
            <end position="1770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1775"/>
            <end position="1789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1797"/>
            <end position="1816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="1818"/>
            <end position="1827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1854"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1867"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1889"/>
            <end position="1907"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CBF79652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="2104" mass="230553" checksum="D3F05CD43B66A2B6" modified="2005-04-26" version="1">MAGNDAENVQYLTPPAVNALRQEARSVDPKNLPTRTLSSDTMREERENLREAAEQTLNVIVDLDLEGRVKWVSPSWKQVVGTDLDTIERRLISDVLVDNKSAFLDAIESLKEDDSRSRFIRVSVQLGPDSVFKYAPAPRPLKREQTDGADSAAEEPSFEMEEDGPAILNLEGQGIMVYDRTAEGVAHTMWMLRPYSKPREVTIDLPSSLVESLGVGAEVLANYLTVLAEAAANEPDQSKHPAPEPVLCRICERQITPWWFEKHSDLCLQEHQAEMDVQIAQENLNEHRHAIVRVLDALEARQGRPISSRDGSSPHLPQPEYKGLPIGPSPVASAPSSGSTSTTSSAPATPPRSRDQSVSGSGHIRARSFAVRRPLARVVELILDLCDTALEINMPVLRESRGDNGDEFRTMSPQSESRISQVLQWHSPSSNTLEQEQGLAALCTDTEQVARSKVDAVIRHRRIVEYAERIRIEYTVLVEECITAALRKAERIAAGQLSDSSSSEDETPSDETTSDPSASSASILVQNAGHEPELPPPVSALTMSMRNATDRFQSGHSSEGKSSSAAVSTGPSSPMECPTPRSHKSVANLLGTSQPSRRGLSLADIDSGDQSDSSIVSSSITGAMRTDSPSSDRSLERKRRSLVLPGLSSSPRRQHSPARVSGPHSPLRMPKPRLSTGAESLSSPIVSPSSNLGELALHHYRHHRRQSSTTSSDLPRPPVSPHLTTASQPQPRPSPPSIKDFEIIKPISKGAFGSVYLSKKKTTGEYYAIKVLKKADMVAKNQVTNVKAERAIMMWQGESDFVAKLYWTFSSKDYLYLVMEYLNGGDCASLVKILGGLPEDWTKKYIAEVVLGVEHLHSRGIVHRDLKPDNLLIDQKGHLKLTDFGLSRMGLVGRQKRVLKSMNEQSGDILKQGSFPRATSIASSRSASFDFQGSGSPGSTPLITPDVAGSMPQPSYFNLNQSGLSRQPSRRASGYRSDSGGSENLNAIFRTLSLNEGETPGAMPIPPPPPSDSAHEEEGQSEPAESPYLQPLQPTHSNVSTGTPPQQTMMPPLMALFDPEDHNRRFVGTPDYLAPETINGVGQDEMSDWWSLGCIMFEFLFGYPPFNAATPDEVFENILHRRINWPGEVEELASPEAIDLMNKLMAINPRERIGANLEEKYPNGGAEIRSHPWFADIHWDTLLEDKAQFVPNLENPEDTEYFDARGATLQAFTEEDESSPQAPVTTGSYIDRPHDALYKVRSQVNSIKRPLMPLHIPPHVREPRSRRLSEPSLADDFGNFAFKNLPMLEKANKDVIQKLRQEALQAQQRQSSNAGTQQQPQTQGQTQATGPTPPSGPSLDGSPLPMSLQRTLSQSKGNNRPASPSSLSQANSSPSRPSQPSSPLLVQFSTGHNHERRKTSGSSSTTASHQSSGSFQPASADQTRVANSNKFGSASSSPIKPNRVGTHSPDKSGPGPHRHGSAPSTRTRSQTIGSQDGELSSSLARETYVPGHHKRRSQLFDVSPSSSDNEDPRAKALLKVQRRRQSSRRLSQINFADGPFFRPLDILICEDHPISRLVMERLFEKLRCRTITVANGAEAVRYALSEVQFDIIMTEFKLPQVNGADVARMVRETRSANRHTPIIAVTSYLKDLPETHHFDSLIEKPPTLTKLTEVLCKFCQWKPPPKDYNPSMFAARQTPPTQSDHSPSSTVSSGFALVPSSSYRGSSREESVGSSYFGDLDSIKAEEVPVIVSRQTDDWSQGTGGLGISEDSTSGQGSADSNRGAQNSTVPFPGLPHAAHSPPALSPSGMITPRKQRSSEAIRAKRESLERKRYECAESGDDEDEELGNLPSRTQSPRNRASRPGSKLGIEMMRTNSRGSVISTSEDALKKDKEAGERSRSGGSDDADEHARDKIRSGRSSLESKFEDLNIPEEAILPSIEDDLSPRNSPSPLALASRSALLTSDTKPPCSRYITKIHKRADSTASLESPKRGQITPPVVFPSQSQNPSEAYPSTPPIVFDGPADSGPYQSSLTPIPDSDATPRPMHTPCPNPDTEKTPRPGRLSTWHWFQSRKKPDQNLLQDCCIYMLASPMQCILTGTIYTVADAGKERCFPRLSARVRARE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="109" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AW01</accession>
    <accession>C8VBL6</accession>
    <name>Q5AW01_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Zinc metallopeptidase, putative (AFU_orthologue AFUA_6G09600)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ANIA_07529</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="2">The Mn(2+) ion enhances activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF79572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_680798.1">
        <property type="nucleotide sequence ID" value="XM_675706.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AW01"/>
    <dbReference type="STRING" id="227321.Q5AW01"/>
    <dbReference type="GeneID" id="2869680"/>
    <dbReference type="KEGG" id="ani:ANIA_07529"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN7529"/>
    <dbReference type="eggNOG" id="ENOG502QQEM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023257_6_0_1"/>
    <dbReference type="InParanoid" id="Q5AW01"/>
    <dbReference type="OMA" id="PECQTMG"/>
    <dbReference type="OrthoDB" id="6119954at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05664">
        <property type="entry name" value="M20_Acy1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.360:FF:000017">
        <property type="entry name" value="Amidohydrolase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017439">
        <property type="entry name" value="Amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01891">
        <property type="entry name" value="amidohydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11014:SF63">
        <property type="entry name" value="METALLOPEPTIDASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G09600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11014">
        <property type="entry name" value="PEPTIDASE M20 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005962">
        <property type="entry name" value="Pept_M20D_amidohydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="3">
        <location>
            <begin position="220"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR005962-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBF79572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="439" mass="47491" checksum="84357C7302E9BC53" modified="2005-04-26" version="1">MQLPSKPSSKPEKQMLTRADRHNALHDIVDRYRPDLQQYESVYRKIHSAPELAGQEKETSSLAASHLQRLGYEVHTNIGGYGVAGVLHNGPGSTVLLRADMDALPLEEKTDLPYASHRIIKNKAGAEVPVMHACGHDTHVAGLMGSAELLHSARDHWSGTLVLIFQPSEEELSGAQAMLDDGLYDKVPKPDVVLAQHVMRMKAGTVGIRAGRLLTASDAFDVRIFGRGGHGSSPHTCIDPIVIGASIITRLQTIVSREITPGELAIVTCGSIQAGYAPNIIPDECNLQLSVRSYDPKVRERLNTSIKRIIEAECDASDAPKKPVIKHTFTAPATINDEKTVKSLLRTFGSYFGSNLVEVEPAAASEDFSLLATAVGAPYVMWNFGGIDTEVWDDAVRQGKRDELPGNHSPFFAPAVEPTIVTAVDAMALGALTFLARDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="119" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AW41</accession>
    <accession>C8VBG6</accession>
    <name>Q5AW41_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">3-oxoacyl-[acyl-carrier-protein] synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">ANIA_07489</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="16">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 10 12">Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF79480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_680758.1">
        <property type="nucleotide sequence ID" value="XM_675666.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AW41"/>
    <dbReference type="FunCoup" id="Q5AW41">
        <property type="interactions" value="445"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5AW41"/>
    <dbReference type="GeneID" id="2869653"/>
    <dbReference type="KEGG" id="ani:ANIA_07489"/>
    <dbReference type="eggNOG" id="KOG1394">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_69_2_1"/>
    <dbReference type="InParanoid" id="Q5AW41"/>
    <dbReference type="OMA" id="QIGHCLG"/>
    <dbReference type="OrthoDB" id="5334845at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00834">
        <property type="entry name" value="KAS_I_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000009">
        <property type="entry name" value="3-oxoacyl-[acyl-carrier-protein] synthase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017568">
        <property type="entry name" value="3-oxoacyl-ACP_synth-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000794">
        <property type="entry name" value="Beta-ketoacyl_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005589">
        <property type="entry name" value="PRK07314.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712:SF336">
        <property type="entry name" value="3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712">
        <property type="entry name" value="POLYKETIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000447">
        <property type="entry name" value="KAS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8 10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="2" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="14">
        <location>
            <begin position="9"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="active site" description="For beta-ketoacyl synthase activity" evidence="11">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR000447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000447-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CBF79480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="430" mass="45382" checksum="F48B2E5088805368" modified="2005-04-26" version="1">MILQLSPSISNVSTSRKGRSITGADASKQGVRRTWKRLLDGHCGIVNIRHRDARYADLPCEIAAVVPSGARAEGRWTASEWLSKDDERKMARFAQYAMAAAEEALEDAEWKPKAEDQLEATGVCLGSGIGNFDEIYDAVVAYDTKGYKKLSPLFVPKLLINLGAGHISMKYGFMGPNHSATTACTTGAHSIGDAARFIACGDADVMLAGGAESCIHPLAIGGFARARSLATAYNDRPEKSSRPFDADRDGFVVGEEHAKARGARIYAEVKGYGCSGDAHHMTAPKANGGGALLAMKKALKNACLEPSAVDYINAHATSTVIGDAAENAAIKALLLGPGGKQKAADVNVSSTKGAIGHLLGGAGAVEALFTVLAIHENVMPPTINLDRLNDGFDFNYAPNEAQERRIDLALTNSFGFGGTNSSLCFSKHGL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2010-06-15" modified="2026-01-28" version="99" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AWB7</accession>
    <accession>C8VCC9</accession>
    <name>MANE_EMENI</name>
    <protein>
        <recommendedName>
            <fullName>Probable mannan endo-1,4-beta-mannosidase E</fullName>
            <ecNumber>3.2.1.78</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Endo-beta-1,4-mannanase E</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">manE</name>
        <name type="ORF">AN7413</name>
    </gene>
    <organism>
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Endo-1,4-mannanase, a crucial enzyme for depolymerization of seed galactomannans and wood galactoglucomannans.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>Random hydrolysis of (1-&gt;4)-beta-D-mannosidic linkages in mannans, galactomannans and glucomannans.</text>
            <dbReference type="EC" id="3.2.1.78"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the glycosyl hydrolase 26 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.78"/>
    <dbReference type="EMBL" id="AACD01000128">
        <property type="protein sequence ID" value="EAA61784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF78427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_680682.1">
        <property type="nucleotide sequence ID" value="XM_675590.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AWB7"/>
    <dbReference type="SMR" id="Q5AWB7"/>
    <dbReference type="STRING" id="227321.Q5AWB7"/>
    <dbReference type="CAZy" id="GH26">
        <property type="family name" value="Glycoside Hydrolase Family 26"/>
    </dbReference>
    <dbReference type="GlyCosmos" id="Q5AWB7">
        <property type="glycosylation" value="4 sites, No reported glycans"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CBF78427">
        <property type="protein sequence ID" value="CBF78427"/>
        <property type="gene ID" value="ANIA_07413"/>
    </dbReference>
    <dbReference type="KEGG" id="ani:ANIA_07413"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN7413"/>
    <dbReference type="eggNOG" id="ENOG502QT55">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016930_2_0_1"/>
    <dbReference type="InParanoid" id="Q5AWB7"/>
    <dbReference type="OMA" id="AWWLWFM"/>
    <dbReference type="OrthoDB" id="5286354at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016985">
        <property type="term" value="F:mannan endo-1,4-beta-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006080">
        <property type="term" value="P:substituted mannan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022790">
        <property type="entry name" value="GH26_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000805">
        <property type="entry name" value="Glyco_hydro_26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016714">
        <property type="entry name" value="MANB/E"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40079:SF4">
        <property type="entry name" value="GH26 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40079">
        <property type="entry name" value="MANNAN ENDO-1,4-BETA-MANNOSIDASE E-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02156">
        <property type="entry name" value="Glyco_hydro_26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018168">
        <property type="entry name" value="Mannan-1_4-beta-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00739">
        <property type="entry name" value="GLHYDRLASE26"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51764">
        <property type="entry name" value="GH26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0326">Glycosidase</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000395077" description="Probable mannan endo-1,4-beta-mannosidase E">
        <location>
            <begin position="23"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="GH26" evidence="4">
        <location>
            <begin position="35"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="296"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="162"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="B4XC07"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3"/>
    <evidence type="ECO:0000255" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <sequence length="355" mass="39620" checksum="37816EA753D5E877" modified="2005-04-26" version="1" precursor="true">MKFSQLILPFSAALSLVGSGVATPTTKPVNPRASRPARNLLAHLVRSAGNGTTLSGQQELKDADWVTDNVGFSPVILGVDLMDYSPSRVEFGAVSTSIEDAITYATQGGIITICWHWGELSHDWMTDERLTTLLTLGSPSGTYNTTEQPWWSNFYTEATSFNLSAAMNPASRDYKLILRDIDAIAEQLARLKDIPVLFRPLHEAEGGWFWWGATGAEPCKALYRLLFDRLTKKHGLNNLLWVWNSKDPLWYPGNEYVDVVSVDVYADNGDHSSQLEAYQALQGLTGNFSKLIALGEVGNIPDPELMREDGAQWAYWVTWNGDFIRGETKNPMEFKKAVYASELVYTLDEIQGWNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AWM3</accession>
    <accession>C8VCP7</accession>
    <name>Q5AWM3_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF1237 domain protein (AFU_orthologue AFUA_2G16720)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_07307</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF78650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_680576.1">
        <property type="nucleotide sequence ID" value="XM_675484.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AWM3"/>
    <dbReference type="GeneID" id="2869842"/>
    <dbReference type="KEGG" id="ani:ANIA_07307"/>
    <dbReference type="eggNOG" id="ENOG502QR7D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023537_1_1_1"/>
    <dbReference type="InParanoid" id="Q5AWM3"/>
    <dbReference type="OMA" id="WFAWCNS"/>
    <dbReference type="OrthoDB" id="7771656at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008313">
        <property type="entry name" value="GH125"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31047">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 157 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31047:SF0">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 157 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06824">
        <property type="entry name" value="Glyco_hydro_125"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028846">
        <property type="entry name" value="UCP028846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01149">
        <property type="entry name" value="DUF1237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010259470" evidence="1">
        <location>
            <begin position="23"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF78650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="523" mass="57951" checksum="0348D7E605A679C2" modified="2005-04-26" version="1">MTLPALVLALSLLSANAREAAALRDEPTILRRACPDYLSYSTAPQPAIECRTFNSSAVEQVIEDVTSRMIDKDLAQLFRNAFPNTLDTTIRWHIDGFTTAIRQSKSKKQNEQWTGPQTFVVTGDINAEWLRDSTNQLANYQTLANRDRRLYNLIQGAINTQAEFVIQSPYCNAFQPPPPSNIPPEAHNQDDQVHPAYEPSVVFECKYELDSLANFLALTADFHENTGSTDFLTSRWYTALDTLLAVLDAQSQPTFNTEGQFVTNQYTFQRTTTLGTETLSLAGVGNPLNSGTGLIRSAFRPSDDATIMGFFIPANAQMAVQLNKTAAMLRTAGGHDDLANNLQDRSTRLRRAIQENAIVNHPKFGDVYAFEVDGYGSHVFMDDANVPSLLSLPVLGYLDKDDPVYQNTRKMILSKDGNPYYLTGSAFHGIGGPHIGLENAWPMSLLIQAQTSDSDIEIRECLNLVKNSSLLGLVHESINVNNIVEYTRPWFAWANSVFAQTVLKIAAERPAIVFGEGAEPYIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AX54</accession>
    <accession>C8VDA3</accession>
    <name>Q5AX54_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HET domain protein (AFU_orthologue AFUA_3G03140)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ANIA_07126</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF79026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_664730.1">
        <property type="nucleotide sequence ID" value="XM_659638.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AX54"/>
    <dbReference type="GeneID" id="2869916"/>
    <dbReference type="KEGG" id="ani:ANIA_07126"/>
    <dbReference type="eggNOG" id="ENOG502SK6F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015641_1_0_1"/>
    <dbReference type="InParanoid" id="Q5AX54"/>
    <dbReference type="OMA" id="GQINDNF"/>
    <dbReference type="OrthoDB" id="2426273at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39596">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39596:SF4">
        <property type="entry name" value="HET DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_3G03140)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF79026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="876" mass="99087" checksum="D94B62AE92FAD799" modified="2005-04-26" version="1">MIPPPTEKGEGPEVAPLLTLKAITFWGADIELDMTETPSQTPWALTKAHIFAILDEDVYRPDKNLGLAPGLIPAEVRRADFTERGPANDREKLSTLQTRAWIEQWCRDAFVLVEAKKENENLNTHFEQLDALFSTLMICNFQLERHKKDRATVVDSAYTVLQRLPRHPPELTFEYSRRSRSNKTESVGNQWPPEYFCGSSAVGIEEVDAPQGYRWTDLRVLSRPCTNVVRTALWLCMNRTNAIAIHEYADTIVKLLDTVTDLQKASTTESDARAWFVLTALFWSAWQQTVMLQLCFDATIRLDYGYASDENYHIIARETPSVMPPREIVERLRPKYMCQWAFELLRADLSSVTQDFRALFEVYERQFGGRESRCNVIDSGRVCDGKAPANCERFLSNRVEDQSAHDFQCPGSSCSLLTWDEQSYMSINGARAVCLETTDDKHIRYRPVSGENMAVSHVWSHGQGGRPETGFNICLHRRYTELARSLGCTSYWMDSPCIPTDDELRDEAIGQINDNFINSKLVLLVDRDLMDIDIEPLTLAAEEAILATLVVCDWNVRAWTLLEGIRGRANLHILCKDNRVIPLKTVLTDILSKSCLSLVSPCLAVQHYTPTRDKVDLVKTEQATCLLNHRHPTKDRDIIIIWSLVCGSNKVVKTAEAFWRSMVGGRLATGFLVSSSPRIKGIRGLSWAPERPNLVPPASASSPKGAASTHAKGSLQQQQYPAFNGENSVAGKITPDGFRAEWLVCKIQRRRALPGAGLFWLHGASDDDDGYFYVYNKGANDKMDVKSLFYLRSVVAPLFKRYRWVSLLLPPWSQRGGEHIDPPVRPFKYQGECEGLVMAIVASNDEAGSEWEWQGVHEWDVKFKMPEFPIANILIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="118" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AXL7</accession>
    <accession>C8V3F0</accession>
    <name>Q5AXL7_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ANIA_06963</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF71843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_664567.1">
        <property type="nucleotide sequence ID" value="XM_659475.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AXL7"/>
    <dbReference type="GeneID" id="2870436"/>
    <dbReference type="KEGG" id="ani:ANIA_06963"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN6963"/>
    <dbReference type="eggNOG" id="ENOG502S1DJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031864_5_0_1"/>
    <dbReference type="InParanoid" id="Q5AXL7"/>
    <dbReference type="OMA" id="NNPTRHM"/>
    <dbReference type="OrthoDB" id="4570620at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004791">
        <property type="term" value="F:thioredoxin-disulfide reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050097">
        <property type="entry name" value="Ferredoxin-NADP_redctase_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48105">
        <property type="entry name" value="THIOREDOXIN REDUCTASE 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00469">
        <property type="entry name" value="PNDRDTASEII"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010277647" description="FAD/NAD(P)-binding domain-containing protein" evidence="4">
        <location>
            <begin position="19"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="5">
        <location>
            <begin position="24"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBF71843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="387" mass="42492" checksum="A92433E1D14E4149" modified="2005-04-26" version="1">MALRTLLTFCIILTCSMAQFNTQYDVLIIGGGPSGLSAASGLARVLRKIALFDSGEYRNKPTRHMHDVIGSDHVDPAEFRAAARAQISFYNVTTFIDTKVVSINATGTANRTTSFTATLANGTTYTGRKVILGSGVKDALPDQVPGLREAFGKGLYWCPWCDGFEHRDQPVGVIGNFSDSYDSVRELYPTLNRQIRVLSNGTANDTAQLERIDKKDSNWRAVFEAYNVTINDRTIQNITRVQDGGEVQEEVIRKELDIFRVYMDDGTFEECGAIMANYGTYQASTLPAQMGLRILGGKIDTTAPGLRTSMKGVWGVGDANSDNSTNVPHAMASGKRAAVYCHVEMAREELALITSNSTKRRAVPEELVVDREMGTVIGDIYDALRMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AXQ1</accession>
    <accession>C8V360</accession>
    <name>Q5AXQ1_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Alpha-L-rhamnosidase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_06929</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF71762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_664533.1">
        <property type="nucleotide sequence ID" value="XM_659441.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AXQ1"/>
    <dbReference type="GeneID" id="2870639"/>
    <dbReference type="KEGG" id="ani:ANIA_06929"/>
    <dbReference type="eggNOG" id="ENOG502QVGI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007933_2_0_1"/>
    <dbReference type="InParanoid" id="Q5AXQ1"/>
    <dbReference type="OrthoDB" id="10036721at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.420.10">
        <property type="entry name" value="Maltose phosphorylase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035398">
        <property type="entry name" value="Bac_rhamnosid_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34987:SF4">
        <property type="entry name" value="ALPHA-L-RHAMNOSIDASE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34987">
        <property type="entry name" value="C, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G02880)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17390">
        <property type="entry name" value="Bac_rhamnosid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-L-rhamnosidase C-terminal" evidence="1">
        <location>
            <begin position="489"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF71762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="556" mass="61765" checksum="952F8CC2EE4B728D" modified="2005-04-26" version="1">MSMINISHVNRLWKRRDAMEGAPSSAHISGVFPTAHRTRPFRLSLEGIIPGSRRSEDVSSLPFRGHFTGRVYRGCRWMEAKYSEARSGLDEPLADGPWTFSNGLANSFRVETFNITRPGHVEPFFQQDGQRWQRLRLLNNDTTVRVCGVGIRSLNEWTEVEQLPGYFASSNPLYNEIWALGAGTLQQACIEKGTALTTWEVAPDGVLLRGQQSAQSALGTSLANCTMTFQAKVLRGGIGWSSVCLDGAKGDRLVWSGDFAHTQRIISASTNRSDLIKRTLEFILDRQEESGPSTGLLAMSPGMGLAAKLASLYNSYRLLDYQMLYLNSLARYYLDSADIKFIREYWEKIEAGLEAMIPHAWAILSNTASTSQADSSIAALSTLRLGLDTKRPLILPQTRQRTSLRMVSGFLLEALFKRARGQPHHAAIVETIDVLLSGLWAAMTDQDEYYTGTSWEYLYPDGRPGLDLFTSPHSWGEAPTYVFTEYLLGIQPTSPGFMEWAFRPVITGMGLSWVEGRVPTPRGSINAGWAVENVTEIRLHVCAPTGTTGIFVSQCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="108" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AY15</accession>
    <accession>C8V2F4</accession>
    <name>Q5AY15_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Guanine deaminase</fullName>
            <shortName evidence="8">Guanase</shortName>
            <ecNumber evidence="8">3.5.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Guanine aminohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ANIA_06815</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 8">
            <text>guanine + H2O + H(+) = xanthine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:14665"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16235"/>
            <dbReference type="ChEBI" id="CHEBI:17712"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Purine metabolism; guanine degradation; xanthine from guanine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.3" evidence="8"/>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF71516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_664419.1">
        <property type="nucleotide sequence ID" value="XM_659327.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AY15"/>
    <dbReference type="STRING" id="227321.Q5AY15"/>
    <dbReference type="GeneID" id="2870495"/>
    <dbReference type="KEGG" id="ani:ANIA_06815"/>
    <dbReference type="eggNOG" id="KOG3968">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012358_0_1_1"/>
    <dbReference type="InParanoid" id="Q5AY15"/>
    <dbReference type="OMA" id="ICCTDEL"/>
    <dbReference type="OrthoDB" id="194468at2759"/>
    <dbReference type="UniPathway" id="UPA00603">
        <property type="reaction ID" value="UER00660"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008892">
        <property type="term" value="F:guanine deaminase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006147">
        <property type="term" value="P:guanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046098">
        <property type="term" value="P:guanine metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000022">
        <property type="entry name" value="Guanine deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014311">
        <property type="entry name" value="Guanine_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051607">
        <property type="entry name" value="Metallo-dep_hydrolases"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02967">
        <property type="entry name" value="guan_deamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11271">
        <property type="entry name" value="GUANINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11271:SF49">
        <property type="entry name" value="GUANINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="9">
        <location>
            <begin position="62"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00051148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00056079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBF71516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="448" mass="49257" checksum="EE55A7BDFEF52466" modified="2005-04-26" version="1">MASVLVFEGAVIHSTDPEHLEILNNATLVVTDGRITAFSKSSETHDAIPRNAQIYRLPPGDFVIPGFVDTHNHAPQWPMRGLGQGLHILDWLNEITFPVEARFADPAYAAMMYEHTVDDFLRQGITTASYYSSRHAEGTKILADICHKKGQRAFVGKCNMDRNAPDYICEKSASESLRETEDCIQHIRGLPGCADADGALVKPVVTPRFAISCSPELLQGLGDIVKRDSTLAVQTHFNEAQQEIDATTELFPQFNGRESDLYESYGLLTSRSILAHCTIMTDYEKERISSLQCGVAHCPIANMTVGGGFMVAPVRDFLRRGIKVGLGTDSGGGWASQMLAVIRQAMIASNAREVSEGMDKALAFEEAFYLATLGGARVLCLDDRIGNFQVGKEFDAVWVTTTTGLKSAMTPREEGDSLRRLFEKYIMTGDDRNVAHVFVKGRRVAGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AY24</accession>
    <accession>C8V2E6</accession>
    <name>Q5AY24_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ANIA_06806</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF71499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_664410.1">
        <property type="nucleotide sequence ID" value="XM_659318.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AY24"/>
    <dbReference type="STRING" id="227321.Q5AY24"/>
    <dbReference type="GeneID" id="2870666"/>
    <dbReference type="KEGG" id="ani:ANIA_06806"/>
    <dbReference type="HOGENOM" id="CLU_785330_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AY24"/>
    <dbReference type="OMA" id="AMFINVI"/>
    <dbReference type="OrthoDB" id="5350673at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053157">
        <property type="entry name" value="Sterol_Uptake_Regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784">
        <property type="entry name" value="STEROL UPTAKE CONTROL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784:SF5">
        <property type="entry name" value="STEROL UPTAKE CONTROL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF71499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="353" mass="39818" checksum="3BE78C5316876FF9" modified="2005-04-26" version="1">MTSVPPPSKKIRRFHHKSRPVLLSQVYARPGALLPLPCLPRLQSIWREALPELAGSFAFISHGLLSVAYIHMASLSPETSRSLLGESAFHVDQALPQYLEVIKNINKDNTAALFGFAMFINVITVESVSEECGALLRVARNVPSKRPETIKRLATHAVRVIHGQQGIFSIFSRFQRWTSNILLYPAIERRGAPVLREPTTSWVSVEDGRLARLSLLWERNPAVPATESQALCAALNSLRAAFVVVTQLTVPALAQAGHEDPCQIEPAAVELEEIHRRLSAVRLDDVLNVFTWLILIPRDFDRMIKEGNMYAMVMLAYYAILLDRTRSGLWWIHQLPHRYVLMAELVLGKERRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="122" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AY97</accession>
    <accession>C8V1X3</accession>
    <name>Q5AY97_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">C2H2 finger domain protein, putative (AFU_orthologue AFUA_7G05960)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ANIA_06733</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
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    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="VEuPathDB" id="FungiDB:AN6733"/>
    <dbReference type="eggNOG" id="KOG1721">
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    <dbReference type="HOGENOM" id="CLU_006466_0_0_1"/>
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        <property type="component" value="Chromosome I"/>
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        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
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        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
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        <property type="entry name" value="VerF-like"/>
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        <property type="entry name" value="XnlR_reg_dom"/>
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    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
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    <dbReference type="PANTHER" id="PTHR40626:SF11">
        <property type="entry name" value="ZINC FINGER PROTEIN YPR022C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="50"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="80"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="140"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="601"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="163"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="182"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="208"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="226"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBF71352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="1003" mass="110874" checksum="FFAC856E29A26B67" modified="2005-04-26" version="1">MAFAVTPVAPLSQGTRPDTEVGSESPDVPEANGPPRKRKRTRKVQVDRKFDCSYEGCGKSYSRAEHLYRHQLNHAPKQIYRCDFPECYRSFVRQDLCVRHRERHTTQGSQLQKRDHFAQAASTSTGGIAKSQIVHTAVQLPQNAPPVLSPPDSKRGSTGPDQPIAASSIPVSSPTSRGFNRFSYQPAAQQHAPTAEVPYSQPCDLPNTPITTTTFNSPPLQRPLQVGSNTRHALNGSPTNELGPARSAALDEPLVSNRSQDLGASYAVSADLTGSLVSPSAYTDQAGLQIPVDGYSDINMAPVTSSASAPLDQTNGLTLDSMAGMAVGDMQFDGLNSCVYPVFGGESNRSPFHMGDDFTAWLFNEPVPGSSMAPPANMVPGFMDAQMQNQFLMSDPSYGNFLNSVIPAHPMSVTSILDPGSPRAIMSEEKRQELLDLMSTRFNEAAYSAVAKRKDALMDGDMDEDRHVLSLSKMQTYIGSYWYHFHAQLPILHRPTFVADKAPNLLLLAVIAIGAATLDSIHGQEVTEAASELADFIMWHLRWEIFMEGDFRPPAKLWVFQALLLLEVYEKMYSTRALHERAHIHHDTTLTLMRRGSSLIGRHSFDSPASLRDDRQARSTTGSTMTPDFAADDSWAHWIKTEATRRVAFAAFVLDSTHATMFGHSAKMVAHELRLPLPCDEALWSATSASEVARVQASLHANGVRPVMFLDGLKRTLNGQRVRTNAFGRTILMAGLLSVSWHMNQRDLQVSSLGVAHALGGRDKWRSALLRAFDNWRRDFDEALQPGMASYPNGYRGRYALDEDNVFESRDVLHGLAHMASHVDIVDCQIFAGARRLMGRAITPRDYNAAREKMVERWATKASARDATFYALKFLAECLLDHQGAHYEGELYCGREDYLLNRPWVIYVAALVVWCYGYALEGPIAGAPALSTVAEQRQDMQAFLRRVGGCREPSDLETMKGRNQCLGLLIILRDGFTNARWELLAEAANLLGSCIDKLREVSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="125" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AYE0</accession>
    <accession>C8V1M5</accession>
    <name>Q5AYE0_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Mitochondrial carrier protein, putative (AFU_orthologue AFUA_7G05390)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">ANIA_06690</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF71254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_664294.1">
        <property type="nucleotide sequence ID" value="XM_659202.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AYE0"/>
    <dbReference type="FunCoup" id="Q5AYE0">
        <property type="interactions" value="55"/>
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    <dbReference type="GeneID" id="2870478"/>
    <dbReference type="KEGG" id="ani:ANIA_06690"/>
    <dbReference type="eggNOG" id="KOG0770">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_3_2_1"/>
    <dbReference type="InParanoid" id="Q5AYE0"/>
    <dbReference type="OMA" id="FFGVYEF"/>
    <dbReference type="OrthoDB" id="415315at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990616">
        <property type="term" value="P:magnesium ion export from mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000170">
        <property type="entry name" value="Mitochondrial carrier protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45667">
        <property type="entry name" value="S-ADENOSYLMETHIONINE MITOCHONDRIAL CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="79"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="183"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CBF71254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="325" mass="35344" checksum="A4F33A8E8BBA7B0B" modified="2005-04-26" version="1">MLAGGIGDTVKTRQQGDPHIPPRYTSMTSSYATIYRQEGLLRGLYGGVTPALMGSFPGTLIFFGVYEFTKRKMLDAGINANVAYLSGGFFADLAASVVYVPSEVAKTRLQLQGRYNNPYFKSGYNYRSTADAFRTIVRQEGFSALFYGYKATIFRDLPFSALQFAFYEQEQRIAKEWVGSRDIGLGLEIFTAVTAGGMAGVLTCPMDVVKTRIQTQQNPAPNSAPAPNASVVREAKSGVQSQSRSISATAAAASPTPSGALRLDNSSFFTGLKMIYKTEGIGGWFRGVGPRGVWTSIQSGTMLVLYQYLLKQFEAFGEAEDTNPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AYE1</accession>
    <accession>C8V1M4</accession>
    <name>Q5AYE1_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Endoplasmic reticulum protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ANIA_06689</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PER33/POM33 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF71253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_664293.1">
        <property type="nucleotide sequence ID" value="XM_659201.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AYE1"/>
    <dbReference type="FunCoup" id="Q5AYE1">
        <property type="interactions" value="135"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5AYE1"/>
    <dbReference type="GeneID" id="2870477"/>
    <dbReference type="KEGG" id="ani:ANIA_06689"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN6689"/>
    <dbReference type="eggNOG" id="KOG4002">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065417_2_0_1"/>
    <dbReference type="InParanoid" id="Q5AYE1"/>
    <dbReference type="OMA" id="NVQYLIM"/>
    <dbReference type="OrthoDB" id="5581259at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071786">
        <property type="term" value="P:endoplasmic reticulum tubular network organization"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061024">
        <property type="term" value="P:membrane organization"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051645">
        <property type="entry name" value="PER33/POM33_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005344">
        <property type="entry name" value="TMEM33/Pom33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12703">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12703:SF4">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03661">
        <property type="entry name" value="TMEM33_Pom33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="188"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBF71253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="280" mass="30882" checksum="9B1820E9EAECFD54" modified="2005-04-26" version="1">MAPPPPSNLPLAERLKALAQTLQFAWFIGHVTLLGSVFRYLLSYATFNYYSGAAQVSYRLAFISAAVTYGIVVYKGHVARGRLQGSLPSILLKLAGDENVQYLGMALVWLYSRQVPLALLPFSVYSVFHVATYTRAHLIPTLQPPSTPAGSPGRANAKQSPLAETIGRFVKQYYDASMDLVAGLEIALLFRLLLAILTFSKGSFILLFIYLTFFRARYSQSSFVQQAVRHFTARVDASMSHQSTPPAVRQGWEGFKDAARQAYQATDVSRFTAGAGKKPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AZL4</accession>
    <accession>C8V1H6</accession>
    <name>Q5AZL4_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Pre-rRNA processing protein Tsr1, putative (AFU_orthologue AFUA_2G12880)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ANIA_06266</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TRAFAC class translation factor GTPase superfamily. Bms1-like GTPase family. TSR1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF69821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_663870.1">
        <property type="nucleotide sequence ID" value="XM_658778.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AZL4"/>
    <dbReference type="FunCoup" id="Q5AZL4">
        <property type="interactions" value="987"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5AZL4"/>
    <dbReference type="GeneID" id="2871002"/>
    <dbReference type="KEGG" id="ani:ANIA_06266"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN6266"/>
    <dbReference type="eggNOG" id="KOG1980">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009858_1_0_1"/>
    <dbReference type="InParanoid" id="Q5AZL4"/>
    <dbReference type="OMA" id="MNLPRFK"/>
    <dbReference type="OrthoDB" id="119302at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000479">
        <property type="term" value="P:endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000461">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012948">
        <property type="entry name" value="AARP2CN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039761">
        <property type="entry name" value="Bms1/Tsr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007034">
        <property type="entry name" value="BMS1_TSR1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030387">
        <property type="entry name" value="G_Bms1/Tsr1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12858:SF1">
        <property type="entry name" value="PRE-RRNA-PROCESSING PROTEIN TSR1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12858">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08142">
        <property type="entry name" value="AARP2CN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04950">
        <property type="entry name" value="RIBIOP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22298">
        <property type="entry name" value="Tsr1_G-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00785">
        <property type="entry name" value="AARP2CN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01362">
        <property type="entry name" value="DUF663"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51714">
        <property type="entry name" value="G_BMS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Bms1-type G" evidence="6">
        <location>
            <begin position="89"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="313"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="8"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="31"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="66"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBF69821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="810" mass="90999" checksum="365BCBC6C97EF0B6" modified="2005-04-26" version="1">MAPTSTVQHHHRSTTKTTHKPYKSGHASKRALKDQAKGKVERAERGTRKTPHQQLMSKLDRRNQARQKQQNKQQERAQAISIFSGQNGAPRHVAIVPLSIDIDTTAIIKALNESVDVTSDVFPDTISRVRIDRFRQNLQYIPAKYDLMSALDACRMADFVVLAISAHLEVEEQGELLLRSIEGQGVSNVIAVVQGLDKINPPKKRPQVAGSLKSFLNHFYPSIDKVLSIDSRQECSNAIRSLCTATPKGIRWRDDRSWMLIEDVKWPESASPEVDDVVLTGVVRGKGLKADRLVHVPGWGDFQIDSITAAPLPTARSKRDDAMNVDESEAPQLLDSPSADRDDLATVAPEEIEMEDDIESMPDTDRKGVLLDDHHYFSDDDDHIPAKPKRLPKGTSEYQSHWFLDDVSDSGSDVMDDDDEEDMQMDVSGAPEDGVFPDNHDAMTEGGPSEYPQSEMFLDPSPEDEAQQLEEYRASRRNEAKDDLEFPDEIELHPNVLARERLARYRGMKSLKTSPWNTAEDRPHEPEDWRRLLQFGDYKGSKNRILREALVGGVNPGTRVDVHLRAVPALLRNRPQPLSLFSLLRHEHKHTVVNINMHLNAAVEEPIKSKQELIVQYGPRRLIVNPVFSSADNTPNNVHKFDRFLHPGRSAVATWIGPLTWGSVPVLVFKSRKTSADPEILDSADAPESTTAVGFSTSTLELIGTGTVVAPDPTRVVAKRAIITGHPYKIHKRVVTVRYMFFNAEDVNWFKALQLWTRRGRSGFIKESLGTHGYFKCTFDGKINPQDSVGISLYKRVFPRKARALEEVAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="146" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AZW0</accession>
    <accession>C8V238</accession>
    <name>Q5AZW0_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">DnaJ domain protein, putative (AFU_orthologue AFUA_2G08300)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ANIA_06170</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF70045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_658682.2"/>
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        <property type="interactions" value="442"/>
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    <dbReference type="STRING" id="227321.Q5AZW0"/>
    <dbReference type="GeneID" id="2871144"/>
    <dbReference type="KEGG" id="ani:ANIA_06170"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN6170"/>
    <dbReference type="eggNOG" id="KOG0712">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017633_0_2_1"/>
    <dbReference type="InParanoid" id="Q5AZW0"/>
    <dbReference type="OMA" id="KWHEDGD"/>
    <dbReference type="OrthoDB" id="550424at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.230.10:FF:000002">
        <property type="entry name" value="Molecular chaperone DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.230.10">
        <property type="entry name" value="Heat shock protein DnaJ, cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01152">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012724">
        <property type="entry name" value="DnaJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044713">
        <property type="entry name" value="DNJA1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43888">
        <property type="entry name" value="DNAJ-LIKE-2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="DnaJ/Hsp40 cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030175753" evidence="7">
        <location>
            <begin position="24"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="8">
        <location>
            <begin position="26"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="9">
        <location>
            <begin position="151"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="6">
        <location>
            <begin position="151"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBF70045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="418" mass="47613" checksum="140905402ABF33E6" modified="2005-04-26" version="1">MRLMRELFFTFAVVLLLVQLVLAAEDYYKILGLDKGASEKDIRRAYRTLSKKFHPDKNPGDDTAREKFVEIAEAYEVLSTPSTRKIYDQYGREGVEQHRQGGQAGGHTHDPFDLFSRFFGGGGHFGHAPGHRRGPDMEFRIGLPLRDFYTGRSFELNIERQQICETCQGTGSADREVITCDKCSGRGVVIQKHMLAPGMFQQVQMQCDKCRGQGKTIKKPCPVCHGHRVVRKDVETSVTIEPGMDKGTRLVFENEGDESPDYIAGDLVLILEEKEPELGTAEEYRTDGTFFRRKGRDLFWKETLSLREAWMGDWTRNITHLDGHVVRLGRSRGEVVQPLSVETVKGEGMPFWSDGHIHDHDDQGPGNLYVEYIVILPDQMESGMEKDFHALWEKWRRKNGVDLAKDSQRPPAPVKDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B025</accession>
    <accession>C8V2K0</accession>
    <name>Q5B025_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CENP-V/GFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ANIA_06105</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF70175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_663709.1">
        <property type="nucleotide sequence ID" value="XM_658617.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B025"/>
    <dbReference type="STRING" id="227321.Q5B025"/>
    <dbReference type="GeneID" id="2870777"/>
    <dbReference type="KEGG" id="ani:ANIA_06105"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN6105"/>
    <dbReference type="eggNOG" id="ENOG502SA0M">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1540025_0_0_1"/>
    <dbReference type="InParanoid" id="Q5B025"/>
    <dbReference type="OMA" id="CHCDCCK"/>
    <dbReference type="OrthoDB" id="9985472at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="5">
        <location>
            <begin position="35"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBF70175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="174" mass="18421" checksum="808D32B3D76044D0" modified="2005-04-26" version="1">MVMSTSAAPTPSASASAPQTANSNGSIACANTVATLTGTCPCGSISVTVTDRSLEGKHGQRDSNPNLTIDAEKTAIQDRQKTLKMYFDLDTMSGRQIEKFFCSSCGCPIMSMTALLPGQVNLTMGLFPRIPASGFETTSSAFQPHRHQNPHPRSLEGRLDDVVQWSAKANAGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B0G6</accession>
    <accession>C8V3D3</accession>
    <name>Q5B0G6_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MFS transporter, putative (AFU_orthologue AFUA_2G10530)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_05964</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF70462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_663568.1">
        <property type="nucleotide sequence ID" value="XM_658476.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B0G6"/>
    <dbReference type="GeneID" id="2870897"/>
    <dbReference type="KEGG" id="ani:ANIA_05964"/>
    <dbReference type="HOGENOM" id="CLU_1981586_0_0_1"/>
    <dbReference type="InParanoid" id="Q5B0G6"/>
    <dbReference type="OrthoDB" id="5086884at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF70462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="126" mass="13787" checksum="D9AE47EA78782E81" modified="2005-04-26" version="1">MAQFLGMLLGSLWGGFVEWRFGWKTMVYSLGVLCFATSWMMLGLGEDVGGYGTKNGAVDAEAGTDTDGPDRVSWFRRMDLRTRTIWGNMKRGWNGIPVLGRQVNSGAQTVDGDTEREGLLAGSGRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="133" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B0J1</accession>
    <accession>C8V3I1</accession>
    <name>Q5B0J1_EMENI</name>
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        <recommendedName>
            <fullName evidence="12">5'-nucleotidase</fullName>
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    </protein>
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        <name evidence="10" type="ORF">ANIA_05939</name>
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    <organism evidence="10 11">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
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            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the 5'-nucleotidase family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF70526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_663543.1">
        <property type="nucleotide sequence ID" value="XM_658451.1"/>
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    <dbReference type="AlphaFoldDB" id="Q5B0J1"/>
    <dbReference type="STRING" id="227321.Q5B0J1"/>
    <dbReference type="DNASU" id="2870825"/>
    <dbReference type="GeneID" id="2870825"/>
    <dbReference type="KEGG" id="ani:ANIA_05939"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN5939"/>
    <dbReference type="eggNOG" id="KOG4419">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005854_7_1_1"/>
    <dbReference type="InParanoid" id="Q5B0J1"/>
    <dbReference type="OMA" id="NYDCDSP"/>
    <dbReference type="OrthoDB" id="7722975at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="AspGD"/>
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    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07409">
        <property type="entry name" value="MPP_CD73_N"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="NT5E isoform 4"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="5'-Nucleotdase_C"/>
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    <dbReference type="InterPro" id="IPR036907">
        <property type="entry name" value="5'-Nucleotdase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006179">
        <property type="entry name" value="5_nucleotidase/apyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575:SF24">
        <property type="entry name" value="5'-NUCLEOTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575">
        <property type="entry name" value="5'-NUCLEOTIDASE-RELATED"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF02872">
        <property type="entry name" value="5_nucleotid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01607">
        <property type="entry name" value="APYRASEFAMLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55816">
        <property type="entry name" value="5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain"/>
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    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
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    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010392560" description="5'-nucleotidase" evidence="6">
        <location>
            <begin position="19"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="8">
        <location>
            <begin position="42"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="5'-Nucleotidase C-terminal" evidence="9">
        <location>
            <begin position="341"/>
            <end position="501"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="533"/>
            <end position="559"/>
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    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="545"/>
            <end position="556"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006654"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBF70526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="582" mass="63726" checksum="5D1254CE66AFB439" modified="2005-04-26" version="1">MKSSLSLAALAAAGTVLADDYLYSKRLAKRFVDDEGHYNVSFFHVNDVHAHLDQFASSGTSCDDPEKGCYGGYARIKTKVTELREQYPDNLWLNAGDEFQGTLFYTYYGGEKIAETLNELKFDAMTLGNHEWDGGDEALGQFLLNLTFPIVSCNVKSEVESLNETIKNYHIFEEHEIAVIGATTTTTPGISSVGNTTTFLDPVAEVQKAVWQIRNETEVNRIILLSHLGYEEDQDLAAKTEGISLIIGGHSHTLLGDMEDAKGDYPTIVEDLNGHEVFIVTAYRWGEYLGAIDLTFDDDGHALAYHGAPIHMDNSTSLDEELDTKIQGWAEAFADFAAEVLGETDAVLVQETCQEGDCLLGQVMADAMYEYRYNQTEGTDDEPALALINSGGVRAEINEGPITRGEVLTAFPFGNAIVELEFSGADLRKILEGAVSYVNQFNGDEITSWFQVSRGVRIEFNPDNEPGDRLVNVTIQGEAIDDERDYRVVTLDFLAGGGDSIFVATDDFITLDTQDEVLTQYIVARTPLSPELEERVVENDGQGENADESQNDEVDGPSDAAGMLAVPAWTALAGIAVAIMAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="140" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B121</accession>
    <accession>C8VFH8</accession>
    <name>Q5B121_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Serine/threonine protein kinase, putative (AFU_orthologue AFUA_6G06720)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">ANIA_05759</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF81259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_663363.1">
        <property type="nucleotide sequence ID" value="XM_658271.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B121"/>
    <dbReference type="STRING" id="227321.Q5B121"/>
    <dbReference type="GeneID" id="2872044"/>
    <dbReference type="KEGG" id="ani:ANIA_05759"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN5759"/>
    <dbReference type="eggNOG" id="KOG0583">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007199_0_0_1"/>
    <dbReference type="InParanoid" id="Q5B121"/>
    <dbReference type="OMA" id="IRSMPHH"/>
    <dbReference type="OrthoDB" id="942095at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd14003">
        <property type="entry name" value="STKc_AMPK-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000434">
        <property type="entry name" value="Serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030616">
        <property type="entry name" value="Aur-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24350">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE IAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 7 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 13" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="24"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="405"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="503"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="765"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="330"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="535"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="558"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="587"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="618"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="637"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="776"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="829"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="145"/>
            <end position="146"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)" evidence="8">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CBF81259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="884" mass="97468" checksum="E0172F928139B478" modified="2005-04-26" version="1">MPPPRTRAEVQAQKQKEKLAQSYNELLKLIGKGSFGKVYLASHKLTNHSKVVLKSSDKEDTNLAREIHHHRQFLHPHIARLYEVIVTEKLVWLVLEYCPGDELYNYLLRNGPLPIDKVKKIFTQLVGAVSYVHSKQCVHRDLKLENILLDKHENVKLCDFGFTREYEGKASYLQTFCGTVCYSAPEMLKAEKYAGEKVDVWSLGIILYALIAGELPYDDDDDQVTKARILNEEPKFNDKFPDDAKALINLLLSKRPLLRPSLDEVLAHPFLSEYAAEQLAILKLPRPPPFSTSLEKTTLHRMKSAGINIDDVVDSVMAQRCDALAGWWALLIEKEQRKEAKRERKRRERDAEAKNIRRLSAASSRLEKISAALVEVDEEGYSTAPLHERGRRDRRSLPSQLAVPELPMLPEPPLQSHNLTTPPPPPPVDKDSIRSHSSTRRLPPAPPPKDRRRSRPSTLHASASQPELAQHGGIFRRRTGRRQYPIISQLASLKHWFVESAKRAKSPHPKSAGGTSRKFLSEKLSPAKGQEGTKKTTLAVSTTGQPNDLATPTQIKRASNASSLAPSSASYPHRRHSYPRQPRPLSTGASHRNSLSPSPLTPRGSYRRSSVGLRGRKSTSSSVSSIRSIHHGHSRSKASSISSNSIGSATTPTARVAKSPHTSVKVLPTTPGASARFPTNIRLVRNPGHGLRDLDEPDGVPTSSYNEAAPAPLLYSPSSSLVFARRKRSTFKGPMLHVANLVASGGMASECPNGDVRMDVPAIKAARPTTRKSQIIEEEEDPEDEYEEVDAFTGTEEEPASPTGVVSSELSDSDHAHSRGQPVLEPAPDLDSSPLRPPRSSSLRTTSRDPVLGSDDSDQAALNASPKSVVSGKRSLYSGVDAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="128" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B149</accession>
    <accession>C8VFK9</accession>
    <name>Q5B149_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Chorismate synthase</fullName>
            <ecNumber evidence="4 8">4.2.3.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ANIA_05731</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21020"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57701"/>
            <dbReference type="EC" id="4.2.3.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>FMNH2</name>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
        </cofactor>
        <text evidence="8">Reduced FMN (FMNH(2)).</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the chorismate synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.5" evidence="4 8"/>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF81316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_663335.1">
        <property type="nucleotide sequence ID" value="XM_658243.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B149"/>
    <dbReference type="FunCoup" id="Q5B149">
        <property type="interactions" value="240"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5B149"/>
    <dbReference type="GeneID" id="2872022"/>
    <dbReference type="KEGG" id="ani:ANIA_05731"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN5731"/>
    <dbReference type="eggNOG" id="KOG4492">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034547_0_1_1"/>
    <dbReference type="InParanoid" id="Q5B149"/>
    <dbReference type="OMA" id="MLSINAV"/>
    <dbReference type="OrthoDB" id="1721239at2759"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004107">
        <property type="term" value="F:chorismate synthase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042602">
        <property type="term" value="F:riboflavin reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd07304">
        <property type="entry name" value="Chorismate_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.150.10:FF:000004">
        <property type="entry name" value="Chorismate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.150.10">
        <property type="entry name" value="Chorismate synthase AroC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00300">
        <property type="entry name" value="Chorismate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000453">
        <property type="entry name" value="Chorismate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035904">
        <property type="entry name" value="Chorismate_synth_AroC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020541">
        <property type="entry name" value="Chorismate_synthase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00033">
        <property type="entry name" value="aroC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003793">
        <property type="entry name" value="PRK05382.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21085">
        <property type="entry name" value="CHORISMATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21085:SF0">
        <property type="entry name" value="CHORISMATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01264">
        <property type="entry name" value="Chorismate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001456">
        <property type="entry name" value="Chorismate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103263">
        <property type="entry name" value="Chorismate synthase, AroC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00787">
        <property type="entry name" value="CHORISMATE_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00788">
        <property type="entry name" value="CHORISMATE_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00789">
        <property type="entry name" value="CHORISMATE_SYNTHASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 8" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="36"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBF81316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="410" mass="44031" checksum="B1FE680B60861521" modified="2005-04-26" version="1">MSTWGDYFRVTTYGESHCRSVGCIVDGCPPGMELTEDDIQPQMTRRRPGQSALTTPRNEKDRVEIQSGTEFGVTLGTPIAMVVRNEDQRPKDYGNKTMDMYPRPSHADFTYLEKYGVKASSGGGRSSARETIGRVAAGAIAEKYLRLSHGVEIVAFVSSVGNEHLFPPTPEHPSPATNPEFLSLIEKIDRATVDAHAPTRCPNEAAAARMTKVIEHFRDNSDSIGGTVTCVIRNVPVGLGEPCFDKLEAQLAHAMLSIPATKGFEIGSGFGGCEVPGSIHNDPFVASEVQTQLGSQNTTKQRLVTKTNNSGGIQGGISNGASIYFRVAFKPPATIGQAQQTATYDFGEGVLEAKGRHDPCVVPRAVPIVEAMSALVVMDSLLAQYARESAKTLLPPLPKTIPTRPTTGSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="103" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B1H3</accession>
    <accession>C8VFZ5</accession>
    <name>Q5B1H3_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Proteasome activator subunit 4, putative (AFU_orthologue AFUA_4G11290)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">ANIA_05607</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="16">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the BLM10 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF81567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_663211.1">
        <property type="nucleotide sequence ID" value="XM_658119.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q5B1H3">
        <property type="interactions" value="328"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5B1H3"/>
    <dbReference type="GeneID" id="2871897"/>
    <dbReference type="KEGG" id="ani:ANIA_05607"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN5607"/>
    <dbReference type="eggNOG" id="KOG1851">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000772_0_0_1"/>
    <dbReference type="InParanoid" id="Q5B1H3"/>
    <dbReference type="OMA" id="ECTQLVP"/>
    <dbReference type="OrthoDB" id="17907at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016504">
        <property type="term" value="F:peptidase activator activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010499">
        <property type="term" value="P:proteasomal ubiquitin-independent protein catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032430">
        <property type="entry name" value="Blm10_mid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032372">
        <property type="entry name" value="Blm10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055455">
        <property type="entry name" value="HEAT_PSME4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035309">
        <property type="entry name" value="PSME4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021843">
        <property type="entry name" value="PSME4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32170">
        <property type="entry name" value="PROTEASOME ACTIVATOR COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32170:SF3">
        <property type="entry name" value="PROTEASOME ACTIVATOR COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16547">
        <property type="entry name" value="BLM10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23096">
        <property type="entry name" value="HEAT_PSME4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16507">
        <property type="entry name" value="HEAT_PSME4_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11919">
        <property type="entry name" value="PSME4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-0647">Proteasome</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Proteasome activator Blm10 N-terminal" evidence="13">
        <location>
            <begin position="19"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Proteasome activator Blm10 middle HEAT repeats region" evidence="12">
        <location>
            <begin position="376"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="domain" description="Proteasome activator complex subunit 4-like HEAT repeat-like" evidence="14">
        <location>
            <begin position="1372"/>
            <end position="1572"/>
        </location>
    </feature>
    <feature type="domain" description="Proteasome activator complex subunit 4 C-terminal" evidence="11">
        <location>
            <begin position="1880"/>
            <end position="1968"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="930"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1848"/>
            <end position="1875"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="848"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="1225"/>
            <end position="1256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="937"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1858"/>
            <end position="1867"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF11919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF16547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF23096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CBF81567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="1968" mass="224015" checksum="7288DD1AC444E0F8" modified="2005-04-26" version="1">MDNPNSKTILTPDNFHNVHTISRATSPGGGPDGVNGDGEPKARVRPRTYPYFKYLPYQTEDEAQRARYLRDILTQLYIAVESGDFSPGAVHWTRELRAWLSLKFDPTRSDRIKLVKLYYELSLAPGIDPNVAERFSSMFMLLTKRKHYLRPIKDLTLDWRPLYRELKAFVLPTESGLVHSSNLKRNVKTLTKLCAFIQLYVDPCELPAMLEEFLPHYSTSFSEGAFVVVGLINLLAPTTPPPESREDLLPQHYMPTYFHLWSLVSRSKTFDQTFLDFFSRLARDSLPAGHIPFSEYGLFTKEQSSLIFTAILRLLEIPVGQSSSPYSALVDISSGLGIMLDRDSRKHPVAHHIARWIVMSLSPACLDKEESILSQLEGLIQAVETFFHPSNSGSWTKTLAQLVYYLTDFFVMRWNREQSGEMEVPQERRLTEPLKRRFVLCLRDVIFMGIYSKSATAMSFSLSTLQGLAFLEPHLILPGALQRIYPSLQGLVEVHRTTSSLRALQILARIIARTKGYRCHLTTLLGMALPGIDANDLEKSLHTLTFIQAACYNIPMTDLTKGRDEINCDMLAMQWIPGEMERMEQEGVEVQLNYDTELSDETEEMILRSSTCGFGDFIISFLGRVFTLLENLPDVSRVRNGSPEENIVNTLPATFMPLLSSLSPEYYEIALTKVVDFVSNHVIHQARDAMAFICNAVCKVNPEKALKRFIPVLIQAIRTEIDDNGAGSTRTTGTDVLPRDRGLVWNVSMLSMCVVHVGDAVLAYKKELFDIAVYMQQKCRGIPTVHVSNFIHHLLLNLTGTYTSDYSLYEPDVVAKGIQPEHWCYRPDPQNLTVKWHVPKRQEIEFAAELFQNQAESALKQLAALTDENSNIRRDGIGKEWSDEVIRNLVLLRLIISGVSVLFDAKAASKTKGSRTNGVSDKAEDVEMTDGVIGTGPEDEEADSSLDTSEEDTVRETYTYPTGYPLEENDPIYVSIHDIRERAGWTLHKVHRYLCEKQEDDVPCFSALYSAYKCWFVDVGIERSAHVLDRVTRLLLADIHPYKMSGIRKDYPRPLLIRRANMYHLQRLRHNAAPRCRSRLDEILLLDIAESCVSAYTETRRNAQTAGESALKVVWGSRLLVIPPLLRALQNGIKENDYARIKGSLFSLLLSSVARTVGRHWKYAPTLVRAFIDASAVDRPSVQRICSSVVYQIMDYGRPMERMAILDRDLVESIAPTSQNVDEQIQQKRNSLNNKRALIEKKKAALAEELVDLAREAHWKVASRAATIVISMGLRFDYIASERLVELVTMGSIDDHPGLRGMYSQGLTALFTMIDVRAICNHDYKSYILGNQNFPAKIKVATKRYEKGWTEEFLASFANPETEYYIDHDFPGWLVWADHMPGYKPNVERDIEYDQIEWQIRSRMGKLFDRAWFKKFFMYLKQEPRDPSADKFRMSCAMLLLYAFELMLRDGLTAATFEDIKEEIEAVYEDGSDKHQHRATAEILGALVSSVTDTSVEKRTLVWEYAFPIVQKIFIEGLTPENSGYWTTFLHMILQCRDPRRVWPLVDWLASFRLDMTTNAAFKESSKINLLHQSIIDAGWHFRLEKPIVQDYLAHLDHPYKGVREAMGQTLATIFRTRYHESYPDVKSLLADQEASSSVGSYPYSPDTDFRQMINDIFTRIEEWRQERTPGQQTPSSYTSGSKTVLLWLDSTLSSHECTQLAPFFAEVFTGQLLHMMDVKEDPELQSLAYHVFRHLPNVPYPAEENSDFIKTLIRIGQTSPSWHQRLRVMINIQIIYFRRLFLLSPSDRDKLFECVASMLEDPQHEVRAGASATLSGMVRCSPEFLRKEIVDRFKKRFTQILVENPLPKRPKMPRMASGLSSPGSSGANTPNPEHTRLVISRHGAVLGLGALIQAFPYSSPPPTWIPEALTTLSVRAASDPGIVGSSVKSIISEFKKTRQDTWHIDAKAFTSDQLEDLSGVLWKSYFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="109" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B1K1</accession>
    <accession>C8VG28</accession>
    <name>Q5B1K1_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vacuolar protein sorting-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ANIA_05579</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Mediates the transfer of lipids between membranes at organelle contact sites. May play a role in mitochondrial lipid homeostasis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the VPS13 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF81629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_663183.1">
        <property type="nucleotide sequence ID" value="XM_658091.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q5B1K1">
        <property type="interactions" value="736"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5B1K1"/>
    <dbReference type="GeneID" id="2871869"/>
    <dbReference type="KEGG" id="ani:ANIA_05579"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN5579"/>
    <dbReference type="eggNOG" id="KOG1809">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000135_0_0_1"/>
    <dbReference type="InParanoid" id="Q5B1K1"/>
    <dbReference type="OMA" id="SGWRPIR"/>
    <dbReference type="OrthoDB" id="428159at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045324">
        <property type="term" value="P:late endosome to vacuole transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045053">
        <property type="term" value="P:protein retention in Golgi apparatus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026847">
        <property type="entry name" value="VPS13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056748">
        <property type="entry name" value="VPS13-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056747">
        <property type="entry name" value="VPS13-like_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017148">
        <property type="entry name" value="VPS13_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026854">
        <property type="entry name" value="VPS13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009543">
        <property type="entry name" value="VPS13_VAB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166:SF93">
        <property type="entry name" value="INTERMEMBRANE LIPID TRANSFER PROTEIN VPS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25037">
        <property type="entry name" value="VPS13_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25033">
        <property type="entry name" value="VPS13_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12624">
        <property type="entry name" value="VPS13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25036">
        <property type="entry name" value="VPS13_VAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037235">
        <property type="entry name" value="VPS13_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="3 4" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Chorein N-terminal" evidence="6">
        <location>
            <begin position="1"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="domain" description="VPS13-like middle region" evidence="7">
        <location>
            <begin position="1085"/>
            <end position="1873"/>
        </location>
    </feature>
    <feature type="domain" description="Vacuolar protein sorting-associated protein 13 VPS13 adaptor binding" evidence="8">
        <location>
            <begin position="1940"/>
            <end position="2516"/>
        </location>
    </feature>
    <feature type="domain" description="Intermembrane lipid transfer protein VPS13-like C-terminal" evidence="9">
        <location>
            <begin position="3038"/>
            <end position="3144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="833"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1367"/>
            <end position="1397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1535"/>
            <end position="1580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1716"/>
            <end position="1745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="834"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1379"/>
            <end position="1395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1539"/>
            <end position="1554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1559"/>
            <end position="1569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR037235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF25033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF25036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF25037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBF81629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="3169" mass="358016" checksum="C6E80D35DD9A158B" modified="2005-04-26" version="1">MLEGLVANLLNRFLGIYVKNFDAKQLNIGIWSGDVKLRNLELRREALDQLHLPLNVVEGHVGELTLSIPWSNLRGKPVKVDIEDVFLLAAPKEDIDYDPEEEEKRANAIKMDKIESAEILKERNSEGMSQEEQRRNQSFTQSLVTAVIDNLQISIKNVHFRYEDSIASPGHPFAVGFTLKELSAVSTDAEWRPTFIQSTSGTTHKMAILGALSVYWNTDAELFGTGRGSDVGAEAQGIDHAELLERLRSGIDNEDGNQFILRPVSGRAGLEMDKTGNHEQPAVNARLLFDEIGFVLDDEQYRDALMLVDLFHCFIRHQEYRKLQPKSRPKEDPRAWFRYAGEAVLSKIHDRNRRWTWDYIKERRDDRIAYIDLFKKKKREEMLSAEETEEFNRLERKLSYEDIRFWRSLARNQLRKENVGVKKPPRQQTWSEWIWGSKKEDSEETAMTEEQRQELYNAIDWDEKKTITESVDVPREWVKLQVNAGLKAGSLTLVRGPHGDANEVMKFVFDNFRAKALQRPDSFFLDLDLGGLRVYDGTTEGSLYPQIVRVKDSLPEPKHRLSQISSSGEFDPEEGVDDLEDEDSLFHLQLEQNPLESDADSVVKVKLKSIEVIYNPKFIVEITRFFRPPERHMESIGAILDSAGATVEGIRQQTRAGLEFALQEHKKVDAQFDVHAPLIIVPESITHESSLCLIIDAGHASVNSELVDRQTMKDLQSKQKRQYDTGDYKELEHLLYDRFLIKLDSTQVVIGPGIETAKAQLGPDVESKNLHIIDRINVDFVLEMCIVPKLTELTRTRISGHLPELHASMSDTKYKGLMKLIDIAIPRFDDEAQDTNTSKNKEGTSITHTRARSSSFQPIGQRELPVVDEESDIEDSDQISKSVDKLPDIHRRDFEFKFTVGRLRGSLFRSDSTDPFREQLLVELVAEGFALDFYMRPFDMVAEVILKSLSVDDYIEANPVPEFKKIISSTGFDADENKDLFYLRFVRVKPESPEFHSTYEGVAMNLDISVSTINLVVTRKTLLTLLDFILLTFTNPQQPNQDTQAALTIEDTESAEQQPQQEGKIRIKADLKSIALILNNDGVRLATLSLHTADVGIFLVGRTMLIQSRIGSLTLIDDVNTGAKKSSDLRRLLTIEGDNFADFKYETFDPEAPEYPGYDSEVFLRSGSIKINFLEEPYRKIINFLVKFGKMQAIFNAARRAAANQANQLQENASRMRFDVVVMTPILVFPGAMSEDRPYDTVTAHLGEIYAKNTFVPLDEEQPDSPAVNLISTGIRNIRLTSRFHYAGGAVEELEMIQKVNLDFSICYLEHQPGNPRPDMEIEGTMSPINLRVSQKQLKFLLDITRTAPNAFVTDSEQQELEAKEALPSLTDSGKETESSLVQSTNQHNVATTDPNGKGENWVRLDMIFKADSVGLELILGKDDAPIGSLDDASLSKFSLNDTQVKLRMLIDGSLESELLIHSFSIRDSRKQETNKFRKIMSLINNDVKQQFMASVSISPGPAKHLIAMLTIDSPRIILALDYLSALQSFANSVFSADEPQEDEEDIESPEEDEPRSSMAESTDGSIRSPSLEEEPQAPSQMTVSFRVSLVDAQIITIANPAIPHTEAIVLGAKEVLFSKQNVSTLHVSKIGMFLCRMDKFETSRLRILDDFTLELSMDSRSQDRGASLTSIDIHVEPLVLRLSLRDILMAIQIVNKASEMRAARILPAETGETKALPESTGTFGSRTRRKSSVGKQASAAATKRSHRRSIGAVNAIDRKPVNKRSVVLQREELKAQVDGVRVILIGDLHDLPLLDWSVKKFNVDARDWSSTLTADTSFDTFVNVYNFSKSAWEPLIEPWQLGIHMAKEVNPDVFSVDVYSHKTMELTVTSATIDLASKSFQFFYTDEDVLSKPRGADAPYRIRNYTGFDLHVWADVAEGEDGPAAKLADGEEYPWRFEDSTSMRETLAPEGQAGLVGVKLEGSGFDSVTRIPVVREGEFLYNLKPKKDTVLHRLLVEVKLGPDNVKYITIRSPLLVENNTQIPVELGVFNPQDGHLLKIEKILPGDARPAPVGAAFMHSIVIRPDQGFGYDWSHEQLYWKDLMRRPTRTIKCLSEGAQQSPPFYFQTNATFNARDPLTKIYPYMRIRIFAPVEIQNLLPYDFKYRIYDKNTRKDWTNFLRKGGVSPVHVVELAHLLLLSVDLEDTVFKQSDFSIINGNAHDFRREHTLSLKDERGLPLKLKLHYFNVPDSGGAFRVSVYSPYLILNRTGLTMEVQSKAFLQSARSAAGQGLRAEAGSRQRRVRPYMYSYATEDQKNRSIIRIGDSSWSKPQSFEAIGSTFEVVLPDRDGRSEYHAGVSVAEGEGKYKLTKIVTIAPRFVLKNKLEEDILVREPGSSNVTDIKGGDLVPLHFLRQAGEKQLCLCFPGVNNQWSSPFNIADVGTVYVKLARQNQRQRLIKIDVIMEAATLFVHLSLEHRNWPFSMRNESDVDFMFYQTNPNLEDDEEDRTNTWRPIRYRLPPRSIMPYAWDFPATKNKSLVLACKGKERRIRLTEIGNLIPMRIPPSQPGEAQKIIDINIVADGPTQTLVLSNFKASKSIYRQQRSQTSQTSINTGFEVKEFDSDVNFKAQLHLGGIGISLINQKMKELLYMTFRDIEVKFKESKAYQTLNTTIKWIQIDNQLYGGIFPMLLYPSVVPKTGKEMEAHPIFHTMITRVKDDSYGVLYIKYATLLLQQMTLELDEDFIFAMLDFTKASGAAWAGKHEDKLCEEQLNIPEPQTEGAAQDVYFELLHLQPMQLDISLMRTERVNVEDTLQPSNPLMFIVDVMTMSMGNVNDAPIKLNALMIENARVSFPVLASNIRRHYTQEFLRQIHVVLGSADFLGNPVGLFNNVSSGVAAIFYEPYQGLVMTDRPQELGYGIAKGFGSFAKNTVFGFSDSISKLTGSMSKGLAAATLDKEFQDQRRMSKTRNRPKHALYGITAGGRAFGNSIVSGIEGIARHPLHGAEKEGIQGFFKGVGKGFLGLATKPAIGAFDLASNLAEGVKNTTTVFDAEGLDRVRLTRFVGMDGIVRPYSQREALGQFWLKTADDGKYFNEDYIAHLELPGRDMLIMLTYDRIMLVRSKKLETDWDIRLTDIQTISKERTGMSIMLKGGANGPFIPVQDESARNWLYKQIAIAVNAFNEKYTNRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="105" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B1N0</accession>
    <accession>C8VG61</accession>
    <name>Q5B1N0_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ANIA_05550</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF81689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_663154.1">
        <property type="nucleotide sequence ID" value="XM_658062.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B1N0"/>
    <dbReference type="STRING" id="227321.Q5B1N0"/>
    <dbReference type="GeneID" id="2871843"/>
    <dbReference type="KEGG" id="ani:ANIA_05550"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN5550"/>
    <dbReference type="eggNOG" id="ENOG502SJVQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018354_10_0_1"/>
    <dbReference type="InParanoid" id="Q5B1N0"/>
    <dbReference type="OMA" id="SISFCEV"/>
    <dbReference type="OrthoDB" id="363185at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF7">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="5">
        <location>
            <begin position="46"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBF81689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="482" mass="51430" checksum="5C449F4E6D4CF9A5" modified="2005-04-26" version="1">MATDSSTAGLTSKLARFSSQHDDIILLTTTIESESFDTLRPIFVNPHASPLAIVRPSTIEAVSATVSFLASNKIPFTVRVGGHDLHGRSVEDGGVVLDLRLLNQVVIDKSGSEAVGGKTATARIGGGVLIGDLLSALEPHGLVTPVGTVSGVGYLGWAMHGGYGPYSSGFGVGIDQIVAAKVVDATGRVVDADGKLLKAIKGAGGAFGVVVEAVVRVYELDSILAGTLIFNSQDLATTIRTFNKAYKALALTESIPSALNIFSCILSSPQTPAPIFILLVNWTSPNLSEGKEWIEKIATLIPSAAATLAANTVQKIKPKPFIEAVSKLVAPSVQGRMYSVSFREITDEVAGVIAHFTSAERMPRDEGVLLEIHELRAVSPSANPNTSSVFSAREPHFVVAACATAVHEENVEKVLKWGEELQVALKRTKRENILPTSYISFISREEMERDQERIFGGHLPFLKDLKRRLDPENVFKAAVSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B1W8</accession>
    <accession>C8VGF9</accession>
    <name>Q5B1W8_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ANIA_05462</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF81868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_663066.1">
        <property type="nucleotide sequence ID" value="XM_657974.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B1W8"/>
    <dbReference type="STRING" id="227321.Q5B1W8"/>
    <dbReference type="GeneID" id="2871751"/>
    <dbReference type="KEGG" id="ani:ANIA_05462"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN5462"/>
    <dbReference type="eggNOG" id="KOG1269">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1378107_0_0_1"/>
    <dbReference type="InParanoid" id="Q5B1W8"/>
    <dbReference type="OrthoDB" id="540004at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF81868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="198" mass="22196" checksum="41CA25AD03AAFEE7" modified="2005-04-26" version="1">MALELRVLALSSITYSKQGEIPLDQVFPRSNLCAENGLSPSRNSEAGIYTMENFVATEPEAVLAGTSRTLKPGDVMGQSMRKINGFATMPTNIFSHPGVFQRMLEGAGFTNVTAQHYSDNTKPMTRLFHLIAYIPHLIVTFLGLEKYFINTIAGVLQSYRGRNHWRIWPSQQRNEAGGTCRRSKRSVIMPSKLNLRFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B1Z1</accession>
    <accession>C8VGI1</accession>
    <name>Q5B1Z1_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_05439</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF81907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_663043.1">
        <property type="nucleotide sequence ID" value="XM_657951.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B1Z1"/>
    <dbReference type="GeneID" id="2871730"/>
    <dbReference type="KEGG" id="ani:ANIA_05439"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN5439"/>
    <dbReference type="HOGENOM" id="CLU_1758784_0_0_1"/>
    <dbReference type="InParanoid" id="Q5B1Z1"/>
    <dbReference type="OMA" id="FIYIAKQ"/>
    <dbReference type="OrthoDB" id="4369471at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="113"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="63"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="121"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF81907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="148" mass="17271" checksum="AA6243E1DEF1B0E6" modified="2005-04-26" version="1">MDSFTESISHKLPYLSSDQKTDLIDSIAKKMISTMIIISREIDRGNLDADNTTPIHNFIRTILRHERAQLRKLERRVARYQRRARRWRAERRRIQHEIAEIVRVLHEAWMEKNLKGSSPRTEARAERRPDSGSGDGSCGNFGESENTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B2G5</accession>
    <accession>C8VH23</accession>
    <name>Q5B2G5_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ANIA_05265</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF82215.1"/>
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    </dbReference>
    <dbReference type="RefSeq" id="XP_662869.1">
        <property type="nucleotide sequence ID" value="XM_657777.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B2G5"/>
    <dbReference type="GeneID" id="2871545"/>
    <dbReference type="KEGG" id="ani:ANIA_05265"/>
    <dbReference type="HOGENOM" id="CLU_164172_0_0_1"/>
    <dbReference type="InParanoid" id="Q5B2G5"/>
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        <property type="component" value="Chromosome V"/>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF82215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="96" xmlns="https://uniprot.org/uniprot">
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        <name evidence="8" type="ORF">ANIA_05187</name>
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    <organism evidence="8 9">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
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    <reference evidence="9" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="CBF81043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="XP_662791.1">
        <property type="nucleotide sequence ID" value="XM_657699.1"/>
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    <dbReference type="AlphaFoldDB" id="Q5B2P3"/>
    <dbReference type="STRING" id="227321.Q5B2P3"/>
    <dbReference type="GeneID" id="2871480"/>
    <dbReference type="KEGG" id="ani:ANIA_05187"/>
    <dbReference type="eggNOG" id="KOG4505">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_008635_5_1_1"/>
    <dbReference type="InParanoid" id="Q5B2P3"/>
    <dbReference type="OMA" id="FFGIRGI"/>
    <dbReference type="OrthoDB" id="5327978at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
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        <property type="evidence" value="ECO:0007669"/>
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    <dbReference type="GO" id="GO:0015385">
        <property type="term" value="F:sodium:proton antiporter activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120029">
        <property type="term" value="P:proton export across plasma membrane"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042391">
        <property type="term" value="P:regulation of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036376">
        <property type="term" value="P:sodium ion export across plasma membrane"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
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    <dbReference type="InterPro" id="IPR004712">
        <property type="entry name" value="Na+/H+_antiporter_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31382">
        <property type="entry name" value="NA(+)/H(+) ANTIPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31382:SF1">
        <property type="entry name" value="SODIUM ION_PROTON EXCHANGER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="34"/>
            <end position="52"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="93"/>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="199"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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    <feature type="transmembrane region" description="Helical" evidence="6">
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    <feature type="transmembrane region" description="Helical" evidence="6">
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    <feature type="transmembrane region" description="Helical" evidence="6">
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    <feature type="compositionally biased region" description="Polar residues" evidence="5">
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        <source>
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        <source>
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        <source>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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        <source>
            <dbReference type="Pfam" id="PF00999"/>
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    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBF81043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="605" mass="66597" checksum="9666ED12452B93A6" modified="2005-04-26" version="1">MPTLSLINFNIVCATLGGFISLFGLVSYLFKERFYLSEALISLLAGVVFSPHGANFIRPLDYALGADQNLDQITLCFTRLVLGVQLVLAGVQLPKRYLQLEWKSLSLLLGPGMAAMWMCSALVIWALVPNLSFLHALAVGACVTPTDPVLSNSIVKGKFADKNVPQPLQRIIIAESGANDGLGYPFLFFALYLIQYIGMDGEGFSGGAGKAMGLWFYETWAYTILLSVGYGVTVGWVSRELLHWAEEKHYVDRESFLVFAIALALFIVVRSPCSMANVKLTNSDWFRLETMDDSLQPTIDMLLNLAVFMWFGAVCPWHLFLENNVIPIYRLIPLGILILLVRRMPIIFAMHKYIEQIESLFQTTFVGFFGPIGVGAVFYLSVSREYLNRITVNGEIRADAQQVSDTIEVVVWFLVICSIVVHGLSIPFAKAGYHLPRTISQVISTSTGDNEPIPLARNSHTHSTATHDNVEATSRRARRHDTSLPTSMSRSHTPQPVAFQIGRSVILSASPSSDAQIGLGSGEEPARPVNLVPKSETVGELTRIRSNDDACGQGDRSGIVKSSSIVDAVSSHDTLPKYAAQWGPGKQEKLIRIESLYSPTSMDLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B3I5</accession>
    <accession>C8V9H5</accession>
    <name>Q5B3I5_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">VanZ domain protein, putative (AFU_orthologue AFUA_3G10980)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ANIA_04895</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF76530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_662499.1">
        <property type="nucleotide sequence ID" value="XM_657407.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B3I5"/>
    <dbReference type="GeneID" id="2872695"/>
    <dbReference type="KEGG" id="ani:ANIA_04895"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN4895"/>
    <dbReference type="eggNOG" id="ENOG502S56A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096870_0_0_1"/>
    <dbReference type="InParanoid" id="Q5B3I5"/>
    <dbReference type="OMA" id="FYWVLDT"/>
    <dbReference type="OrthoDB" id="63581at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006976">
        <property type="entry name" value="VanZ-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF037970">
        <property type="entry name" value="vanZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28008">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G10980)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28008:SF1">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G10980)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04892">
        <property type="entry name" value="VanZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="5"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="VanZ-like" evidence="3">
        <location>
            <begin position="36"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBF76530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="212" mass="23552" checksum="73F569FC65061D1B" modified="2005-04-26" version="1">MRIRYPFAGAFIFLLILSAYIGLLPHSESSSIPANLQPNDKLLHVVIFFLISLIFYWIPDTSRRRTLHLTLVVCTLALGVGSEILQGILPNGRSFDPFDLLANIVGSLGAVGLCGWYHRRMLERRRKSRFGSLGEGGEDDVELGMSPDHREREQLEPQESGVVNLEQEVDNWDENAVDTWDTEDGDDPSSGLTGKAAADKDQKGLAEGKRND</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B5Q0</accession>
    <accession>C8V501</accession>
    <name>Q5B5Q0_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ANIA_04130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF74639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_661734.1">
        <property type="nucleotide sequence ID" value="XM_656642.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B5Q0"/>
    <dbReference type="GeneID" id="2873551"/>
    <dbReference type="KEGG" id="ani:ANIA_04130"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN4130"/>
    <dbReference type="HOGENOM" id="CLU_2096854_0_0_1"/>
    <dbReference type="InParanoid" id="Q5B5Q0"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF74639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="116" mass="12884" checksum="1831E3A6D119E4FD" modified="2005-04-26" version="1">MPGKPCLLQSQAGTVGVCGLYGPVMSLMSRDLIQMTCMCVRNRTHKMQGMQYALLLPYLSKAVFHCFRYTDCVYRPMLQPYKCITAFDHFLAHELATQFSTSLPPSGDKNIGAGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="116" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B5X6</accession>
    <accession>C8V5I4</accession>
    <name>Q5B5X6_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">aldehyde dehydrogenase (NAD(+))</fullName>
            <ecNumber evidence="3">1.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ANIA_04054</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>an aldehyde + NAD(+) + H2O = a carboxylate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:16185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="3"/>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF74799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_661658.1">
        <property type="nucleotide sequence ID" value="XM_656566.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B5X6"/>
    <dbReference type="STRING" id="227321.Q5B5X6"/>
    <dbReference type="GeneID" id="2873476"/>
    <dbReference type="KEGG" id="ani:ANIA_04054"/>
    <dbReference type="eggNOG" id="KOG2450">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005391_0_0_1"/>
    <dbReference type="InParanoid" id="Q5B5X6"/>
    <dbReference type="OMA" id="INGGPFN"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000001">
        <property type="entry name" value="Aldehyde dehydrogenase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000012">
        <property type="entry name" value="Betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="7">
        <location>
            <begin position="29"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBF74799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="488" mass="51927" checksum="2DD43DBAB1F7A329" modified="2005-04-26" version="1">MAQVEVPSTNGSGKSVETRLFINGEFQPSSDGKTFSLIDPFTQNSVAEVSQATEEDTNNAVAAAKAAFPAWRDRSPADRGACLHKLAALIRENNEEFARLEALSTGRPVSRYFDATVSADTFSYFAEAGWTVQGTSSLNTPGHLNMTVKQPYGVVACIIPWNVPMAFFAFKVAPALAAGNTVVLKSSEKAPLTSALAATLIAEAGFPPGVINILSGFGTPAGSTLASHMDVRCLSFTGSSFTGQRIQAAAAASNMKIVHMELGGKSPALIFEDADLENAAQATQFSIQCLSGQTCMANSRIYVQESVADEFLALFKEKFGSAVLGNPLESGTTHGPQVDGLQYERVKSYITIGEQDGKLSMGGDAGNGYFVKPTVFEGVPEDSRIVKEEVFGPVVVINTFKTEEEAIKKANASEFGLYASVFTKDLDRAVRTSKLLEAGTVGVNTTSPNVAKDMPFGGYKMSGVGREGFMHSLDNFLETKTILIKMSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B6B1</accession>
    <accession>C8V658</accession>
    <name>Q5B6B1_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Nuclear polyadenylated RNA-binding protein Nab2, putative (AFU_orthologue AFUA_6G08450)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ANIA_03919</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ZC3H14 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF75092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_661523.1">
        <property type="nucleotide sequence ID" value="XM_656431.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B6B1"/>
    <dbReference type="STRING" id="227321.Q5B6B1"/>
    <dbReference type="GeneID" id="2873334"/>
    <dbReference type="KEGG" id="ani:ANIA_03919"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN3919"/>
    <dbReference type="eggNOG" id="KOG3702">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027088_1_0_1"/>
    <dbReference type="InParanoid" id="Q5B6B1"/>
    <dbReference type="OMA" id="CPYAHQS"/>
    <dbReference type="OrthoDB" id="438553at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008143">
        <property type="term" value="F:poly(A) binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043488">
        <property type="term" value="P:regulation of mRNA stability"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.40:FF:000001">
        <property type="entry name" value="Nuclear polyadenylated RNA-binding protein nab2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.30:FF:000002">
        <property type="entry name" value="Nuclear polyadenylated RNA-binding protein Nab2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.40:FF:000002">
        <property type="entry name" value="Nuclear polyadenylated RNA-binding protein Nab2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.40">
        <property type="entry name" value="Nuclear abundant poly(A) RNA-bind protein 2, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055046">
        <property type="entry name" value="Nab2-like_Znf-CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040366">
        <property type="entry name" value="Nab2/ZC3H14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043094">
        <property type="entry name" value="Nab2/ZC3H14_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14738">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14738:SF29">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22683">
        <property type="entry name" value="Nab2-like_zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14608">
        <property type="entry name" value="zf-CCCH_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nab2-like CCCH zinc finger" evidence="9">
        <location>
            <begin position="434"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="92"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="265"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="476"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="92"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="169"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="268"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF22683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBF75092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="503" mass="54324" checksum="50076F1D22AAE976" modified="2005-04-26" version="1">MATVAVGTPLAEALSNAIQPKLVEMGWSSDSSDSALTEYVILMLVNGKTQEQIASELSNDLLGLGEGDTQAVDFSRWLFEQVDAFNQQINGQSAQTSNDNAQAIPSFDDQETTTSQVQGHEKGPQSSDTNMSDAGISGDGIPTGPKSMRNGRQGGQAGRGRMLNQINRNLDRGDSGLHRIRDQTGGGRINSHSRGGNRGGRFNQNGNGRLFGGRGGMGMGNNQMAGAAGNLMNMNPNDQMHLMSLLEEQARMMAQLMPGFVSPAINPAFQQSGPQRSLSDRVERPRGPRQHGAFGNRAQRADSKNNDTDMDMTSDGAVQNGQDENNTDNICHFNLRCTRKDCPFAHQSPAAPEGTPVDVSDVCSYGAACKNRKCTGRHPSPAVKSAHQAEELCRFFPNCTNPHCHFKHPSMPLCRNGADCSTPDCKFTHLQTACKFNPCLNPTCPYKHAEGQRGAFADKVWTADSAKAKARISERKFVNDEDAPEELIKPETGAEPSSQEIVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="104" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B6N8</accession>
    <accession>C8V700</accession>
    <name>Q5B6N8_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Sm domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_03792</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Component of the heptameric LSM1-LSM7 complex, which consists of LSM1, LSM2, LSM3, LSM4, LSM5, LSM6 and LSM7. Component of the heptameric LSM2-LSM8 complex, which consists of LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8. The LSm subunits form a seven-membered ring structure with a doughnut shape.</text>
    </comment>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF75374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_661396.1">
        <property type="nucleotide sequence ID" value="XM_656304.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B6N8"/>
    <dbReference type="FunCoup" id="Q5B6N8">
        <property type="interactions" value="324"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5B6N8"/>
    <dbReference type="GeneID" id="2873216"/>
    <dbReference type="KEGG" id="ani:ANIA_03792"/>
    <dbReference type="eggNOG" id="KOG3168">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076902_4_0_1"/>
    <dbReference type="InParanoid" id="Q5B6N8"/>
    <dbReference type="OMA" id="THEYRCP"/>
    <dbReference type="OrthoDB" id="368909at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031417">
        <property type="term" value="C:NatC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06168">
        <property type="entry name" value="LSMD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034110">
        <property type="entry name" value="LSMD1_Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050914">
        <property type="entry name" value="snRNP_SmB/NAA38-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10701:SF5">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 38, NATC AUXILIARY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10701">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN-ASSOCIATED PROTEIN B AND N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sm" evidence="2">
        <location>
            <begin position="8"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF75374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="113" mass="12489" checksum="C3B1F7E9D2F654F3" modified="2005-04-26" version="1">MDESKAVQYLESLIGRTLRVHATDTRIFVGVFKCTDAARNIILANTHEYRYPTTAAVQDAALNTTPETPKESQKLKLNMTSRFIGLVVVPGQHITSIELEETPQSRKASATVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="119" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B6Y4</accession>
    <accession>C8V7L1</accession>
    <name>Q5B6Y4_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">EH domain binding protein epsin 2 (AFU_orthologue AFUA_6G12570)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">ANIA_03696</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the epsin family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF75589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_661300.1">
        <property type="nucleotide sequence ID" value="XM_656208.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B6Y4"/>
    <dbReference type="FunCoup" id="Q5B6Y4">
        <property type="interactions" value="124"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5B6Y4"/>
    <dbReference type="GeneID" id="2873115"/>
    <dbReference type="KEGG" id="ani:ANIA_03696"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN3696"/>
    <dbReference type="eggNOG" id="KOG2056">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="InParanoid" id="Q5B6Y4"/>
    <dbReference type="OMA" id="STEFYDI"/>
    <dbReference type="OrthoDB" id="4033880at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
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    <dbReference type="GO" id="GO:0030125">
        <property type="term" value="C:clathrin vesicle coat"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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        <property type="term" value="F:clathrin binding"/>
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        <property type="project" value="GO_Central"/>
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    <dbReference type="GO" id="GO:0070530">
        <property type="term" value="F:K63-linked polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000147">
        <property type="term" value="P:actin cortical patch assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd16991">
        <property type="entry name" value="ENTH_Ent1_Ent2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EH domain binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DUF1720"/>
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        <property type="entry name" value="ENTH"/>
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        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12276:SF110">
        <property type="entry name" value="EPSIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12276">
        <property type="entry name" value="EPSIN/ENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DUF1720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01417">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02809">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00273">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00726">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="10" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="ENTH" evidence="13">
        <location>
            <begin position="10"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="158"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="337"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="440"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="536"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="170"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="218"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="239"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="341"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="355"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="366"/>
            <end position="383"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="440"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="537"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010130"/>
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            <dbReference type="ARBA" id="ARBA00022490"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022843"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CBF75589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="561" mass="62953" checksum="76D7302750D44CD0" modified="2005-04-26" version="1">MSKVVRSVKNVTKGYSAVQVKVRNATSNDHWGPTGTEMAEIASLTFGSPTDFYEIMDMLDKRLNDKGKNWRHVLKSLKVLDYCLHEGSELVVTWARKNVYIIKTLREFQYIDEDSRDVGQDVRVAAKELTALILDEDRLRSERSDRKLWKSRVNGLDDYHGGHANGLPPPRRERRDRRRDDEDAEYRLAIEASKHEAEEERRRRAQAQSNGEEDDEDLAKAIKLSKEEEELRRRELEESNAQSLFDDSTPAAQPQPTGYNQGYQQQSAVDWFGNPINPQQPLTTGYLNNQYANPTGFQGQATGMNGYTNGFQAQPTGYTQNPYAQNNFLQPQATLQPQQTGFSTNNPWGTDMFNQQQQHQQPQQQESMLTPGSNNPWGNNQPESLKPMPTGSNNPFAARTQLQPQFQASRPATSGAPSLNTLSEERATKQFSNQFQSSTNPIANYQAPQSSQQNQSLAPPKPMDPHTARLNALLATSEGQDTFGNTGDLRIPAQHTAPGTFVNSAGQGLDRLRAAHTGNNPFFGQQQQQFVPQQTGYLQQPNNPWGAHQQQPQQGGSLIDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="102" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B713</accession>
    <accession>C8V3U1</accession>
    <name>Q5B713_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">HMG box protein, putative (JCVI)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ANIA_03667</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF75653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="XP_661271.1">
        <property type="nucleotide sequence ID" value="XM_656179.1"/>
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    <dbReference type="HOGENOM" id="CLU_022445_4_0_1"/>
    <dbReference type="InParanoid" id="Q5B713"/>
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    <dbReference type="OrthoDB" id="2307332at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
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        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
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        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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            <end position="275"/>
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    <feature type="DNA-binding region" description="HMG box" evidence="3">
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            <begin position="279"/>
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            <begin position="135"/>
            <end position="156"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="4">
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            <begin position="305"/>
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    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CBF75653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="499" mass="55298" checksum="B9D2173AE5DB16F5" modified="2005-04-26" version="1">MQRRLIENHPPSPPQSTDGDFASDASQFGDMYPLYGTPEPYAGAGQGHDESFNEQSSVTINMRYAPTAEYPQNASLHHPVRTWPFSPTAEYSRQELRQAQVLHNGARFSTPPADDGFASGSLDSAPSARWPSPARRQHASRARVLRSPRQRRRAKNRSSTDSSFVLTEPLSVLTKDMTHVPLKDMESHVNRPIEERLADTAKNDGKIPRPMNSFMLYRSAYANRVKEYFRQQNHQVVSSASGASWNKETPEIRAKYERLAVIEKRNHLKAYPGYKFTPAKDKKKRSTFDDSHSFSGEFTPEGSPAQRNISRNSTFSTPEIGSGWNGGHPTPPDMGDHGLPTDGYFPSLWPTSHPARQPVGMMLTSDPSHFMQPASNPEEIHYAPSTMLAGLPGAAHHDLLQPQGGQVDPALLNYPGSTIHPEGGSQVYGHPHYQMWQEGNNNVYAPFEASMEPSPDSYAGAPSIQPGIDGHEIWDSSQRATLEPAGGDFDNWLNQPAGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="112" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B7A2</accession>
    <accession>C8V4F1</accession>
    <name>Q5B7A2_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">CCCH zinc finger and SMR domain protein (AFU_orthologue AFUA_4G13020)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ANIA_03578</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF75847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_661182.1">
        <property type="nucleotide sequence ID" value="XM_656090.1"/>
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    <dbReference type="AlphaFoldDB" id="Q5B7A2"/>
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    <dbReference type="GeneID" id="2872996"/>
    <dbReference type="KEGG" id="ani:ANIA_03578"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN3578"/>
    <dbReference type="eggNOG" id="KOG2401">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015244_0_0_1"/>
    <dbReference type="InParanoid" id="Q5B7A2"/>
    <dbReference type="OMA" id="RQDAIKH"/>
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        <property type="component" value="Chromosome II"/>
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        <property type="evidence" value="ECO:0000318"/>
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        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="entry name" value="CCCH zinc finger and SMR domain protein"/>
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    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="DUF1771"/>
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        <property type="entry name" value="Smr_dom"/>
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        <property type="entry name" value="Smr_dom_sf"/>
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    <dbReference type="InterPro" id="IPR045124">
        <property type="entry name" value="Su(sable)-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
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    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13119:SF12">
        <property type="entry name" value="PROTEIN SUPPRESSOR OF SABLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13119">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08590">
        <property type="entry name" value="DUF1771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01713">
        <property type="entry name" value="Smr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14608">
        <property type="entry name" value="zf-CCCH_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01162">
        <property type="entry name" value="DUF1771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00463">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160443">
        <property type="entry name" value="SMR domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50828">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="280"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="310"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="Smr" evidence="8">
        <location>
            <begin position="609"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="280"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="310"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="57"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="393"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="83"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="413"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBF75847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="734" mass="79585" checksum="7A2DED358A1020A2" modified="2005-04-26" version="1">MVTEELLEDCLQILQDKSLDEEDQVEKIEEFLREKTSLSGTSLENAVLDILWRQRNRTLPDSSPPPPRHTVIRRSSPAPWQMARSSTPLSPHSNLGTSPGSSSWLQSSKGGISRPPLSSTVSPFTSPRPSPRLALAQPIPHSPNLNAYEFSDQQSHVSDFYGDLGSDSNVDWLVADDAMSTTSSVGGLSMHGGLSATAPEFVPDMSPHDILRTVLGDKRSNEEIESALEANGYDLGATIAALTQGADAGAAPSLPDDSRVVVGKSMTMEPPKSTSTPGHNRSPVVCKYWLSTGQCLRADCRFSHDLTSHLCKYWVMGNCLAGDGCPFSHDPSALIANLSVDGNSSATSAGIAFQVDNAPDAFPPLQSTPGSSEQWAGQLGSKYPGYLYGGPGGKNAPHLGGKRSGSMTNLSRPHSRPGSRHQHRELNPTALSVDDPDAFPTLAAVNAKNSGKKNHGRKNRDNNTTRDNMPTSLADVVRMSPAPASGGKGKPSSKNNQTKGRENSAAAQSIPAPQHIPWLETGSRTNQQYIKYRTEAIRHGTVRNKFLQSAAQAWNRNDARAAKALSLRGQAENEAMRKCHREAARQLYEERNKHLLNAGLDDASEELYVDLHGLHPEEAIEYLEKILLKHAREGRRIIYAITGTGHHSKNGKDKIGKAVKAWLNEWKYLFREFSVPGERGGYVGGILGIDPSSYDKTLAKNLEAEANGDEDASQPVLTMGKIQLLKRGDIESQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="101" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B7X5</accession>
    <accession>C8VHT5</accession>
    <name>Q5B7X5_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amidase, putative (AFU_orthologue AFUA_5G09140)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_03355</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the amidase family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF82881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_660959.1">
        <property type="nucleotide sequence ID" value="XM_655867.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B7X5"/>
    <dbReference type="STRING" id="227321.Q5B7X5"/>
    <dbReference type="GeneID" id="2873755"/>
    <dbReference type="KEGG" id="ani:ANIA_03355"/>
    <dbReference type="eggNOG" id="KOG1211">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009600_18_1_1"/>
    <dbReference type="InParanoid" id="Q5B7X5"/>
    <dbReference type="OMA" id="LCHSATS"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895:SF83">
        <property type="entry name" value="AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="2">
        <location>
            <begin position="89"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF82881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="682" mass="74106" checksum="BEBFA697BC160257" modified="2005-04-26" version="1">MSVFSLNINSSNPVTLETLDRVADSLGITVAEHEKEDYLRLLAVYHESAEALMGLPDYVPMVDEERFPRHNIHFPTSEENPLNAWAWRCEIQDQTRSATSGLLAGRTIVLKDNIAVKGVPMLMGTDMVSGYIPDTDATVVTRVLEAGAVVKGKAVCENLCHSATSSSAATGSVHNPFARGYSSGGSSSGCGSLVANGDVDLAIGADQGGSVRVPAGWCGLYGLKPTFGLMPYTGCGSNEPTNDHLGPMTRTLLDNALLLQATAGNDNIDDRSFAAPLPSQIPEYYSILTSLPNPKFLSGVKIGVISEGMNMPGIDPRVHKTVSKAISLFTELGATVSDVSVPFHSRGAAIWTPISKSGNFHSRMNRAFGRRGHALTDLNTLFHPLTQEKWDRAYTSTKNIYLNGAYAETQFPGILSKAMNLSRRLRDEYDAALREYDVLVLPNLPYIANSHVDPATATPLEMIAKQVGLTANTAPFNQSGHPVLAMPVGMLEILEGPLAEKGVKLPGICSSLFERWDRKVGFLCSVISTVDITVHKTWKTAGVLLSVLYLRQRDLRPFINHHWRHPWPSELGAQLDPLRHLSESGFHHSSGGIVYNCVFLSSELTILYHVDLNPTTEASVITGCTPLLSASIPATVATKTNNNLRRVADSLPLSVRLIAAIELCERFAYFGILRPMQNYIQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B8K3</accession>
    <accession>C8VIJ2</accession>
    <name>Q5B8K3_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_03127</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF83356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_660731.1">
        <property type="nucleotide sequence ID" value="XM_655639.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B8K3"/>
    <dbReference type="GeneID" id="2873875"/>
    <dbReference type="KEGG" id="ani:ANIA_03127"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN3127"/>
    <dbReference type="HOGENOM" id="CLU_829068_0_0_1"/>
    <dbReference type="InParanoid" id="Q5B8K3"/>
    <dbReference type="OMA" id="YLQCASS"/>
    <dbReference type="OrthoDB" id="4506991at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010252213" evidence="2">
        <location>
            <begin position="22"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="261"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF83356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="335" mass="35724" checksum="9025455B079BA23C" modified="2005-04-26" version="1">MHFSLHLSALTLLGSLPLTLGEKETDLGYLKTTSFPSCDSSYKLDCFCEANAQLEAANAKENRNGLKSASAFTAPQVELAPEVEELCAENGVPKEEITRYLCDDTAVPATPRRGSTPMIRMGQKKAEESESESDCGSAHHKERDDEETASIRPLAAKRSISPGSTRLLIPENDSLEREVAVDNDDDDDKEEKDDEDRMASTNAIYEIVTVTETRTECSCAETATPVHGDEEDEENNTHMNMSGAMHGTQIAVAILPTPSQMSAAHAAQSDSASTSSVRVASSNDPVPTGVDAQQKHGGDEDVDAKMFEGTASGVVGVSRGVVLGLFGVAVGFVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="116" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B9B6</accession>
    <accession>C8VJC0</accession>
    <name>Q5B9B6_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ANIA_02864</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF83851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_660468.1">
        <property type="nucleotide sequence ID" value="XM_655376.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B9B6"/>
    <dbReference type="FunCoup" id="Q5B9B6">
        <property type="interactions" value="14"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5B9B6"/>
    <dbReference type="GeneID" id="2874030"/>
    <dbReference type="KEGG" id="ani:ANIA_02864"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN2864"/>
    <dbReference type="eggNOG" id="KOG0252">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_46_12_1"/>
    <dbReference type="InParanoid" id="Q5B9B6"/>
    <dbReference type="OMA" id="VRGICGF"/>
    <dbReference type="OrthoDB" id="2153661at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001407">
        <property type="term" value="P:glycerophosphodiester transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000140">
        <property type="entry name" value="Putative MFS phospholipid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508:SF10">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="176"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="252"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="304"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="335"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="359"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="427"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="39"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBF83851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="473" mass="51884" checksum="DED0E4789A8F7281" modified="2005-04-26" version="1">MVMANASKDSRTEAQETVVDQEIEQQKPYRPARWQSNLTILSCYIANFSDGFQNGLANPTNVIFKHLLGSSRYPSEMQTRISNSLIIGAILGVVVLGYVSDMVSRRAGLVFTSGLVTVSTLMAALALQVHPSYNMLWFFVIVRGISGFGVGGEYPPSAAAGLEESDDFRRRYRGPVFVSFTTLMATLASPILQIIYLISLKASSNNLHITFHAMYSIAAILPFTVMLLRFFMADSTLYHNSNFKQSPQNRSLRFYVLLVRRYWARLLTTSTAFFLYDFINFPNSIMSSTIISSLVTDNNIQTTAIWQVILSALPVPGVVLGAYLTNAIGRRNTGLLGFAGYTVTGFLIGGLFHKISKHMAAFVVLYGLLNAFGHMGPGATIGLISSESFPTAMRGMGYSVALALGRTGAAVGTQCFMPLRERGGDSATFYLAGGVAVLGMFVYWFLPESGELDLENEDRKLEGYLRENEIAMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="107" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B9M1</accession>
    <accession>C8VJW3</accession>
    <name>Q5B9M1_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">RNA processing protein Emg1, putative (AFU_orthologue AFUA_3G06010)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">ANIA_02759</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF84070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_660363.1">
        <property type="nucleotide sequence ID" value="XM_655271.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B9M1"/>
    <dbReference type="FunCoup" id="Q5B9M1">
        <property type="interactions" value="916"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5B9M1"/>
    <dbReference type="GeneID" id="2874369"/>
    <dbReference type="KEGG" id="ani:ANIA_02759"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN2759"/>
    <dbReference type="eggNOG" id="KOG3073">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055846_1_1_1"/>
    <dbReference type="InParanoid" id="Q5B9M1"/>
    <dbReference type="OMA" id="VHNTFEL"/>
    <dbReference type="OrthoDB" id="269804at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005880">
        <property type="term" value="C:nuclear microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070037">
        <property type="term" value="F:rRNA (pseudouridine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd18088">
        <property type="entry name" value="Nep1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1280.10:FF:000003">
        <property type="entry name" value="Ribosomal RNA small subunit methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005304">
        <property type="entry name" value="Rbsml_bgen_MeTrfase_EMG1/NEP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12636">
        <property type="entry name" value="NEP1/MRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12636:SF5">
        <property type="entry name" value="RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE NEP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03587">
        <property type="entry name" value="EMG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="alpha/beta knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="8" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CBF84070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="260" mass="28937" checksum="B232D6C86BA47253" modified="2005-04-26" version="1">MSESVQVAGKRKRARTQSCPPPELPQLVAEQHVPIAPNDKETQRLIVVLSHASLETFKASHGGRNGTARDEKYSLLNSDEHIGVMRKMNRDISEARPDITHQCLLTLLDSPVNKAGKLQIYIHTAKGVLIEVNPSVRIPRTFKRFAGLMVQLLHRLSIRSTNSQEKLLKVIKNPITDHLPPNCRKVTLSYEAPVVRVKDYIESLGPKESICIFVGAMAKGQDDFADSFKDDTISISNYSLSASVACSKFCHAAEEVWDIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B9Z4</accession>
    <accession>C8VHG6</accession>
    <name>Q5B9Z4_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_02636</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF84307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_660240.1">
        <property type="nucleotide sequence ID" value="XM_655148.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B9Z4"/>
    <dbReference type="GeneID" id="2873822"/>
    <dbReference type="KEGG" id="ani:ANIA_02636"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN2636"/>
    <dbReference type="eggNOG" id="ENOG502SN3P">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006526_1_0_1"/>
    <dbReference type="InParanoid" id="Q5B9Z4"/>
    <dbReference type="OMA" id="EWEHIAG"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="386"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF84307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="550" mass="62754" checksum="D469640A9F83567D" modified="2005-04-26" version="1">MSVIAKLFQSSDVVPTGLIIRDGFNIARYRTAGEPEIATWDYTGDQDDEPAIECLVLEECRKNSCTLALRHPKERGDDDAVHDPDFEPVEMDFSNDPYECDSEYESADAMSVSESEEENEECSDRKVYEDFLSRTIDRPHQLRGEPVGAFAYSTAVKMDTLVPITSGELPDNYDPEGLEHLPGAACGEANAYSGAAISLAEMRGCRTAQFLVHKSCALGGWQPDGLHEAWEMTEDWFLSGVCDGMISRDCGYPTVWPARGGLEKVASDNVNFDPEHFDSNKLAMPFHPWCFDTFSRQSKALFNRVNVSGLMKWRNAECSYEAFFEFPRIADVFEAQEQFWRHVPGQEYLSANPLYVPGLPALLRAAERNDTTGYETASVSASFFQTNRLASLPLDVRLHIIDFLESADILRLRVVSKAFAQLPNSVWHRLVRGEMPWLWEAWDDSEIDHTPSPWTTMTANEVKFFNQTRKRYHKVLRNESTTVDTTVEHLLPRPILETESVNLTKANTNWHTVYTTIKRNWACLKGLRNRKRIWEDVAEIIRRIQKYDEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BAQ9</accession>
    <accession>C8VNM7</accession>
    <name>Q5BAQ9_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CorA-like transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_02371</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF86709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_659975.1">
        <property type="nucleotide sequence ID" value="XM_654883.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BAQ9"/>
    <dbReference type="STRING" id="227321.Q5BAQ9"/>
    <dbReference type="GeneID" id="2875465"/>
    <dbReference type="KEGG" id="ani:ANIA_02371"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN2371"/>
    <dbReference type="HOGENOM" id="CLU_1170630_0_0_1"/>
    <dbReference type="InParanoid" id="Q5BAQ9"/>
    <dbReference type="OrthoDB" id="5396681at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058257">
        <property type="entry name" value="CorA-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26616">
        <property type="entry name" value="CorA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CorA-like transporter" evidence="1">
        <location>
            <begin position="31"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF26616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF86709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="237" mass="27145" checksum="A32B389B03042464" modified="2005-04-26" version="1">MAENRDETNLARQLTNLVSLKVPTSNGGRSIFSKGPENFQVSLIDLDTYTKGPAEPYIIRNEEQLREYIKSRPEHQARIISICCKNSITPLLITQSAMQILLDRYDIGFEFMDLVQSFGRKPQVSDAGHGRMTIHRRRNGAYGAVFKSYEVIETNYTDRWVGVFNRFSPERPGQNLWIILHPKQNSEAQQRIESATKHALDFCNNPSLLHLVILSTYMGNWRLCIQSIGEKIEEMPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BB18</accession>
    <accession>C8VMW0</accession>
    <name>Q5BB18_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Low-temperature viability protein ltv1 (AFU_orthologue AFUA_5G06520)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_02262</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LTV1 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF86491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_659866.1">
        <property type="nucleotide sequence ID" value="XM_654774.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BB18"/>
    <dbReference type="FunCoup" id="Q5BB18">
        <property type="interactions" value="442"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5BB18"/>
    <dbReference type="GeneID" id="2875304"/>
    <dbReference type="KEGG" id="ani:ANIA_02262"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN2262"/>
    <dbReference type="eggNOG" id="KOG2637">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028555_1_0_1"/>
    <dbReference type="InParanoid" id="Q5BB18"/>
    <dbReference type="OMA" id="TAQHFTL"/>
    <dbReference type="OrthoDB" id="5852896at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007307">
        <property type="entry name" value="Ltv1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21531">
        <property type="entry name" value="LOW-TEMPERATURE VIABILITY PROTEIN LTV1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21531:SF0">
        <property type="entry name" value="PROTEIN LTV1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04180">
        <property type="entry name" value="LTV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="21"/>
            <end position="63"/>
        </location>
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            <begin position="164"/>
            <end position="189"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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            <end position="357"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="436"/>
            <end position="455"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
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            <begin position="27"/>
            <end position="38"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="44"/>
            <end position="59"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
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            <begin position="164"/>
            <end position="178"/>
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    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
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            <begin position="201"/>
            <end position="215"/>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
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        <location>
            <begin position="441"/>
            <end position="452"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF86491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="483" mass="53184" checksum="E01DA273E86F9B72" modified="2005-04-26" version="1">MPPRKQWIDKKNATTYQLFHRSQNDPLIHDPDAQDRILHPVYGPAAQAPSTSSASTSSAGRAKHLSDLASEFGNDSIRKNEGEAANYGIYFDDSKYDYMQHMRELGTGGGAYFVEATNKDKGKTKSLKLEDALAQTSLNNDDTRSNWGNRSSVGSAYGAYSTASTYSRKPTYQDQQDVPDSIAGFKPDMDPRLREVLEALEDEEYVDEKDDDDFFGELTAEGQEMDPGDWEDTLFDHDEDEGWESDATEKAPVQPSTSSLKQESNVAPGELPEHDAPAPDMNPDDQDWMREFAKFKKAGKTKTTPAAPPSIVPSEQRSTLASTVFTAGGTPIRRKKRKGALTNPSAYSMTSSSLARTEGHRLLDDRFERLEALYALDEEEEYDDSMSMVSGMTGMTDMSTASSQAPSLIDANGNAVAPRHDFNNIMDDFLDGWDNNTSAQAKRKGAKNKRGKNGNEAIGIRMLDEIRQGLGPARVPGRVSGKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="101" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BB95</accession>
    <accession>C8VMH4</accession>
    <name>Q5BB95_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Endonuclease</fullName>
            <ecNumber evidence="17">3.1.30.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">ANIA_02185</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="22" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="22">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2 17">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 17">Belongs to the DNA/RNA non-specific endonuclease family.</text>
    </comment>
    <dbReference type="EC" id="3.1.30.-" evidence="17"/>
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        <property type="protein sequence ID" value="CBF86343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_654697.1"/>
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    <dbReference type="STRING" id="227321.Q5BB95"/>
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    <dbReference type="KEGG" id="ani:ANIA_02185"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN2185"/>
    <dbReference type="eggNOG" id="KOG3721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055174_0_2_1"/>
    <dbReference type="InParanoid" id="Q5BB95"/>
    <dbReference type="OMA" id="YVMPNQV"/>
    <dbReference type="OrthoDB" id="5418055at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="term" value="P:apoptotic DNA fragmentation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="NUC"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Nuclease 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Extracellular Endonuclease, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018524">
        <property type="entry name" value="DNA/RNA_endonuclease_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044929">
        <property type="entry name" value="DNA/RNA_non-sp_Endonuclease_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001604">
        <property type="entry name" value="Endo_G_ENPP1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020821">
        <property type="entry name" value="ENPP1-3/EXOG-like_nuc-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044925">
        <property type="entry name" value="His-Me_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040255">
        <property type="entry name" value="Non-specific_endonuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13966:SF5">
        <property type="entry name" value="ENDONUCLEASE G, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13966">
        <property type="entry name" value="ENDONUCLEASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01223">
        <property type="entry name" value="Endonuclease_NS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00892">
        <property type="entry name" value="Endonuclease_NS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00477">
        <property type="entry name" value="NUC"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="His-Me finger endonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01070">
        <property type="entry name" value="NUCLEASE_NON_SPEC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 17" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="10 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0464">Manganese</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 16 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6 17" id="KW-0540">Nuclease</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA/RNA non-specific endonuclease/pyrophosphatase/phosphodiesterase" evidence="20">
        <location>
            <begin position="94"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="ENPP1-3/EXOG-like endonuclease/phosphodiesterase" evidence="19">
        <location>
            <begin position="102"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="28"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="28"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="50"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="15">
        <location>
            <position position="159"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010052"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
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    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR640255-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR640255-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU366055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="CBF86343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="334" mass="36217" checksum="D020368588C453D3" modified="2005-04-26" version="1">MSKATVAAIAAASAATGAGITALFYSRPSPQQQKPATATPTTAPAPPTAPVAVPVPTQPASPSLASKSATATGPVDPAGIYQYGFPGPIADTITSLPLTGAYDRRTRNPSWVAEHITPASLASKNADRKHSTFFEDSTIPPLFRAKLADYFRSGYDRGHQVPAADAKWSQEAMDGTFALTNMCPQVGEGFNRDYWAHFEEFCRDLTKRYPSVRIITGPLYLPHRDADGKWRVNYEVIGTPPNVAVPTHFYKVVYAEEGPGLPSGKVALGAFVLPNARISNDKRLAEFEVPLEAVERASGLEFASKLEPTRRKRLCQEVRCDIVVREFNNAKKKA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2026-01-28" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BD89</accession>
    <accession>C8VMM0</accession>
    <accession>Q56UN7</accession>
    <name>CSN1_EMENI</name>
    <protein>
        <recommendedName>
            <fullName>COP9 signalosome complex subunit 1</fullName>
            <shortName>CSN complex subunit 1</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">csnA</name>
        <name type="synonym">csn1</name>
        <name type="ORF">AN1491</name>
    </gene>
    <organism>
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="8089" last="8094">
            <title>An eight-subunit COP9 signalosome with an intact JAMM motif is required for fungal fruit body formation.</title>
            <authorList>
                <person name="Busch S."/>
                <person name="Schwier E.U."/>
                <person name="Nahlik K."/>
                <person name="Bayram O."/>
                <person name="Helmstaedt K."/>
                <person name="Draht O.W."/>
                <person name="Krappmann S."/>
                <person name="Valerius O."/>
                <person name="Lipscomb W.N."/>
                <person name="Braus G.H."/>
            </authorList>
            <dbReference type="PubMed" id="17470786"/>
            <dbReference type="DOI" id="10.1073/pnas.0702108104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <scope>FUNCTION</scope>
        <scope>IDENTIFICATION IN THE CSN COMPLEX</scope>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 3">Component of the COP9 signalosome (CSN) complex that acts as an regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunit of SCF-type E3 ubiquitin-protein ligase complexes (By similarity). The CSN complex seems to link protein degradation to sexual development. Required for fruit body formation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the COP9 signalosome (CSN) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CSN1 family.</text>
    </comment>
    <comment type="sequence caution" evidence="4">
        <conflict type="erroneous gene model prediction">
            <sequence resource="EMBL-CDS" id="EAA64621" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EMBL" id="AY574249">
        <property type="protein sequence ID" value="AAT73769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AACD01000022">
        <property type="protein sequence ID" value="EAA64621.1"/>
        <property type="status" value="ALT_SEQ"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF84973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BD89"/>
    <dbReference type="SMR" id="Q5BD89"/>
    <dbReference type="DIP" id="DIP-60925N"/>
    <dbReference type="IntAct" id="Q5BD89">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5BD89"/>
    <dbReference type="EnsemblFungi" id="CBF84973">
        <property type="protein sequence ID" value="CBF84973"/>
        <property type="gene ID" value="ANIA_01491"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AN1491"/>
    <dbReference type="eggNOG" id="KOG0686">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022348_1_1_1"/>
    <dbReference type="InParanoid" id="Q5BD89"/>
    <dbReference type="OMA" id="IYLQNWA"/>
    <dbReference type="OrthoDB" id="422427at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070791">
        <property type="term" value="P:cleistothecium development"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.570:FF:000022">
        <property type="entry name" value="COP9 signalosome complex subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019585">
        <property type="entry name" value="Rpn7/CSN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045135">
        <property type="entry name" value="Rpn7_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14145">
        <property type="entry name" value="26S PROTESOME SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14145:SF2">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10602">
        <property type="entry name" value="RPN7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0736">Signalosome</keyword>
    <feature type="chain" id="PRO_0000314738" description="COP9 signalosome complex subunit 1">
        <location>
            <begin position="1"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="PCI" evidence="2">
        <location>
            <begin position="249"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="17470786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="498" mass="55664" checksum="B7EDC2906BD334FE" modified="2008-01-15" version="2">MEPMLPEAGEAALLSSYAPQASGSMGVDPDPITGLVSTSAAPLVRVEEAPKFELESYIANYTGRTRFNRLYLIGTCSSYLAVDALKAAIAEAKSGKDVARYLRAVQALADVAPNEPEATIDSDWVERSQKVVKAETDRLEHELRGYKNNLIKESIRMGNEELGQHYHRIGDLTSAFKAYSRMRDFCTTPSHIASMLFKIINVAIERGDWLNVQSNVHRLRSQGGKPEEQAKHQPKISAAMGLSQLHSGSYLEAANSFIATDPSLGDTFNEVLTSNDVAVYGGLCALASMDRNELQRRVLDNSSFRNFLELEPHIRRAISFFCNSKFRPCLEILEAYRADYLLDIHLQRHVQVLYNRIRTKSIQQYLIPFNRVSLESMAKIFVLGNPTSQSSQSDSKSAFVQELISLIQDGTLDARIDLEKHVLVSTQGDKRIEVQEAVLDSLDNYVREAHLRLLRSNIIRAGLEVRPLGEDRRTKLEERGKKGHSAIGNLLRATGMKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BDA9</accession>
    <accession>C8VME2</accession>
    <name>Q5BDA9_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_01471</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF84926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_659075.1">
        <property type="nucleotide sequence ID" value="XM_653983.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BDA9"/>
    <dbReference type="GeneID" id="2875030"/>
    <dbReference type="KEGG" id="ani:ANIA_01471"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN1471"/>
    <dbReference type="HOGENOM" id="CLU_2038044_0_0_1"/>
    <dbReference type="InParanoid" id="Q5BDA9"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF84926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="121" mass="13058" checksum="BA787A1952015241" modified="2005-04-26" version="1">MAPVCSASRLGDYGSVPSSTRQPAKTEIDNASSTGSSTAKLCGTDPGAWAVATENETGGKEPSETIGDDWSSGYTLRTEHRARFNSQQPLTNPMRHNAPLIRPIDFLGLWPEPDLRTRLVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="101" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BDR6</accession>
    <accession>C8VS67</accession>
    <name>Q5BDR6_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylesterase type B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ANIA_01314</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF87734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_658918.1">
        <property type="nucleotide sequence ID" value="XM_653826.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BDR6"/>
    <dbReference type="GeneID" id="2877091"/>
    <dbReference type="KEGG" id="ani:ANIA_01314"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN1314"/>
    <dbReference type="eggNOG" id="KOG4389">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006586_10_4_1"/>
    <dbReference type="InParanoid" id="Q5BDR6"/>
    <dbReference type="OMA" id="GAWYAPP"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142:SF1">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="3">
        <location>
            <begin position="53"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBF87734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="594" mass="64554" checksum="32C41213722D884E" modified="2005-04-26" version="1">MANLLSVTVGAVLLAIGAIFYQRLLDTLSLSASLKVVDSMRDIIYLGSLSPAGIEHFQNIFYAEEPTGQRRFAAPVPTRPAKGSVIDATRAGAWCPQGTGDILPFTSRVTNISENCLSLRIARPAGTQKDAKIPVAVWIHGGGHALGSASDILYEPDGLVKLAVSDGMPLIYVGINYRLGIFGFATSKALIDKRDTNAGLRDQRLALELTVIGQSVGASDIGLQLTAFGGDQDVPFQQAIMMSGGPGLNFNSKPGLVANNTAAIAQQLGCQRKDDSQTLECLRDVPFEQLTNLSVAASRAARPPFGEGYFYPTIDGDFIQDRPSQLLRAGKFAKGISLVASWVTNDGAWYALPTTATDDEVLGSFGLWLHNLSEPTKERLLQLYPLEDFKHMIKPENEGRISPQYYRAAQLNRDIWFTCPVLDFTWQYVEAGGVEASRVRLYEFNETRYAPVFDSMGVSMWGVAHLSDIPYLFYNDHLGAGADNSDAQLALARDFSQRIIQFVHGTSGGVGDRLQPWPPAFLNDLSKFSTGDMPSHISLLLFGGPDGSTPASCNEGVGADVETLTDAEKALHWEQLFSRCAFINGQRFREEAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BDY2</accession>
    <accession>C8VSJ3</accession>
    <name>Q5BDY2_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Trafficking protein particle complex II-specific subunit 65 IgD3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_01248</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
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    </evidence>
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        <source>
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    <accession>C8VUF4</accession>
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            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
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            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CBF88433.1"/>
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        <property type="nucleotide sequence ID" value="XM_653476.1"/>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
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    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
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        <location>
            <begin position="36"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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    </feature>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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</entry>
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    <accession>Q5BEY0</accession>
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            <fullName evidence="1">Uncharacterized protein</fullName>
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        <lineage>
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            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
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                <person name="Asai K."/>
                <person name="Machida M."/>
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                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
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            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
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                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
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            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF88562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_658504.1">
        <property type="nucleotide sequence ID" value="XM_653412.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BEY0"/>
    <dbReference type="GeneID" id="2876677"/>
    <dbReference type="KEGG" id="ani:ANIA_00900"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN0900"/>
    <dbReference type="HOGENOM" id="CLU_1562858_0_0_1"/>
    <dbReference type="InParanoid" id="Q5BEY0"/>
    <dbReference type="OrthoDB" id="4438748at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF88562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="171" mass="19704" checksum="013CE9CBDA4C618B" modified="2005-04-26" version="1">MPYDFPPPQPLYPHVPFAADRGSEGPFRRPVHHGYQEFQTRLFLDEYRFPGSQQTYQPPHLEAGIQTPLAHPWEGENAYELEGPPVAQNIQLRGDAPEFVPGWKPSVTEESESKPKEPCWLIPYQCLCLFYLRTVYIKQNLALESIQTQTEAQAPQLRSTVWVLILPSKHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="106" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BF81</accession>
    <accession>C8VQH7</accession>
    <name>Q5BF81_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 11">Chitin synthase</fullName>
            <ecNumber evidence="2 11">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">ANIA_00799</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Polymerizes chitin, a structural polymer of the cell wall and septum, by transferring the sugar moiety of UDP-GlcNAc to the non-reducing end of the growing chitin polymer.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9595"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="EC" id="2.4.1.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cell membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the chitin synthase family. Class I subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2 11"/>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF88759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_658403.1">
        <property type="nucleotide sequence ID" value="XM_653311.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BF81"/>
    <dbReference type="STRING" id="227321.Q5BF81"/>
    <dbReference type="CAZy" id="GT2">
        <property type="family name" value="Glycosyltransferase Family 2"/>
    </dbReference>
    <dbReference type="GeneID" id="2876577"/>
    <dbReference type="KEGG" id="ani:ANIA_00799"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN0799"/>
    <dbReference type="eggNOG" id="KOG2571">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004760_3_1_1"/>
    <dbReference type="InParanoid" id="Q5BF81"/>
    <dbReference type="OrthoDB" id="2429941at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013616">
        <property type="entry name" value="Chitin_synth_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF9">
        <property type="entry name" value="CHITIN SYNTHASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01644">
        <property type="entry name" value="Chitin_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08407">
        <property type="entry name" value="Chitin_synth_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="4 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="453"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="499"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="529"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="579"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="627"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="725"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="765"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin synthase N-terminal" evidence="12">
        <location>
            <begin position="48"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00046324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU366040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CBF88759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="797" mass="89973" checksum="13781D4C8C76BE0D" modified="2005-04-26" version="1">MDQGTAETVYDISPKLCSQQSWTGPAAAGPRPTIELVPIERKRPVLEAGLVRRNVVLTCPVHPQIRSQVNGKYDDDELMTVRYSALTCEPSGFHKERFTLRQNLYIKPRRTELLIIIPLCDESGTDLGRTLTSIFANIQYISSQKRVKTWKRHGWKRCVVCILGDGRGRLSEEAKAALTLIGLWQPALAVRDVQGQDVRAHLFEYTTCARLRDSTLQPLPECPQTPVQMILCLTERYQGPQSCGKWLSEAILPELDPQMCVFVPAGAKPSADAIYRLWERLHLHPRCGGVVGQTEMRASLLTWALNPLAAAYGVHLKLASVLENPFQSFLGFAPAFPTQLSAFRCQQERKSQDQTSGGWEAASVRDEPKSITWGSHISDRRLWAFDILSRRWNRDRLDYVRKARAHVQAPPSIDAYIVDLQHYMQDRIVFMMDSWSTMQNIEGGLRKLKFAALLIYSCLNLVVSWFAIGNTFLIFFFINHYFASDSIIGRHSSATETGLLTLYTFLLMVSVLCGLTYQPHTNRLRIIRTVITVGWILLAAYILIAIIVVGFKTTRPTFHILSNNPTDFREWFDERRFSLAILPLVAIYAIRLLASMLFLDPWIIFAAVGFRLQSSPQSNSTDAEQSIQYVLCILAHVNFINITTFMYSKLSVSEEQNTANGGIPIPTNYFVRPGNKVHLDSPSDDDLNKAYDDSLAQLLDPPDLESARLPSRKCENTSRVYPDKVVLTWALSNILLCAVILHAIPSVKGLAGDDLENMNRCPSTAYLLVIFWLIGSLEGVKFMGAILFIIKEVIYFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BFW1</accession>
    <accession>C8VSE0</accession>
    <name>Q5BFW1_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">C2H2 finger domain protein, putative (AFU_orthologue AFUA_6G11250)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_00569</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
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            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
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        <property type="component" value="Chromosome VIII"/>
    </dbReference>
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        <property type="entry name" value="Znf_C2H2_type"/>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
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</entry>
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    <accession>C8VT51</accession>
    <name>Q5BG52_EMENI</name>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
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            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
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            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
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        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
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        <property type="nucleotide sequence ID" value="XM_652990.1"/>
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        <property type="component" value="Chromosome VIII"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF89408.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    </evidence>
    <sequence length="205" mass="22053" checksum="9E163E6D4E6C65E1" modified="2005-04-26" version="1">MWQYLRYCLTQSSPVCHQDLPQECHETADTSPVYPLQNSTAGEDTVAFRFDSGAYTTQTSAGAGYRGDAAAAKFFKEIAREFYGDTVEQVYGYIYGGSGGSLQTVGAIENTIGVWDRGLALIQAIPISNPDNFCIRALAGLVLGEKADQVIDGVQPGGSGNAFAGHEEAERLVLLEATALGMPWLAGKISRARQTYLEAFRPGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BGJ1</accession>
    <accession>C8VU00</accession>
    <name>Q5BGJ1_EMENI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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        <name evidence="2" type="ORF">ANIA_00339</name>
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        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
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            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF89691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_657943.1">
        <property type="nucleotide sequence ID" value="XM_652851.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BGJ1"/>
    <dbReference type="STRING" id="227321.Q5BGJ1"/>
    <dbReference type="GeneID" id="2876117"/>
    <dbReference type="KEGG" id="ani:ANIA_00339"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN0339"/>
    <dbReference type="eggNOG" id="ENOG502RWR6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019222_0_0_1"/>
    <dbReference type="InParanoid" id="Q5BGJ1"/>
    <dbReference type="OMA" id="HNRHLNM"/>
    <dbReference type="OrthoDB" id="5395390at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="586"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="95"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="586"/>
            <end position="609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF89691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="790" mass="88564" checksum="77F181C0BFF57523" modified="2005-04-26" version="1">MARSARRSRPVRSNRTHVPSYNEDSGPSDSLGGDSETDQHRSGGLSHSLRSRDSNRVPISYREESTDDDVLNNSHEEDPDDSLHRTYPLPDADMRATPTTQSTASRPRRRRSVKTRSQTQKAKRTPTKRRLELGRPLNKRRKAADETDTLFASSGVIPPWQTLPYHILFDIFLRASYPLVDERALKRNRTVGWLLNIALLCRGFHEPALAALYHSVPTIPALKSHGLLSLLMKPQDSLSTNYRNKIKELHVDVEALLLYKSGPAFGYFDLPALVQHTPQVNTLRLYHRDDFMVGLPRWGIPSSKWLYPDALFKTINSNSIRLHSWDWNARFMTTQNLLPLMLENHNEASFKSIQDLRIFHICAEDPDGDDQVVGMTDTREDVLAAALNVLPMLRRLEFLGSSILNDCLLPKLPLNLTSLSINNCDDVTTANFSLFLGTHGHSLRELSLSHNRHLSLSFVVDLKGSCPCLEKFTVDISIHDLSSYHDVEPHFDELLSPSEIPSWPTTLQHLELIQLRKWKENTAEAFFASLIEAAPELRSLRTLVISAILKTGWRDRASFRERWIGKLKKVFLRRSTPPNPALCTLARNSEGLSSGKPSEGSQPNDTEFASPSKRKSARIASLRHFDGEEIRSLSTRAHQINENDSELDTPATQGMCNVVEIRIDNQRPRDTQFNESDFLDDELSGDEEWTGQDVDLGDGGHACSSKVCGENTNSLNSGAESAATPTLVSVGRYPGTLGFFIQQSASGLSAMFVSPFMAQQCSSFYALELQFLPKFGTLDGSISDKSILPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BGQ5</accession>
    <accession>C8VUC9</accession>
    <name>Q5BGQ5_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Lysosomal L-cystine transporter (Eurofung)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">ANIA_00275</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="13">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-cystine(out) + H(+)(out) = L-cystine(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:66172"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:35491"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:66173"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lysosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cystinosin family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF89833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_657879.1">
        <property type="nucleotide sequence ID" value="XM_652787.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BGQ5"/>
    <dbReference type="FunCoup" id="Q5BGQ5">
        <property type="interactions" value="206"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5BGQ5"/>
    <dbReference type="GeneID" id="2876050"/>
    <dbReference type="KEGG" id="ani:ANIA_00275"/>
    <dbReference type="eggNOG" id="KOG3145">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046327_0_1_1"/>
    <dbReference type="InParanoid" id="Q5BGQ5"/>
    <dbReference type="OMA" id="WIDVIYT"/>
    <dbReference type="OrthoDB" id="75720at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015184">
        <property type="term" value="F:L-cystine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015811">
        <property type="term" value="P:L-cystine transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000016">
        <property type="entry name" value="Cystinosin homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000071">
        <property type="entry name" value="Lysosomal L-cystine transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005282">
        <property type="entry name" value="LC_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00951">
        <property type="entry name" value="2A43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13131">
        <property type="entry name" value="CYSTINOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13131:SF5">
        <property type="entry name" value="CYSTINOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0458">Lysosome</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0769">Symport</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="92"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="199"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CBF89833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="284" mass="32164" checksum="4DA7EE4AA41099AF" modified="2005-04-26" version="1">MSQLEAFIRALSRLLGWIYTFCWSASFYPQPIDNYRRKATTGLAIDFPTINVLGFVCYAVYTGTFLYSPVIRHQYAARHPLAPEPTVRFNDFAFALHAVVLSGLVYSQFWPSIWGFRVSRFQRVSKPIAGLFWGAFVAVAMVICVILVKSPDDGYEPLSWAWIDVIYTLSYVKLVITVVKYVPQAWVNHKRKSTRGWNIVQILLDFTGGVLSLAQLILDSAFQDDWSGVTGNPIKFLLSNVSIFFDLLFMVQHYILYRDAENKDKNNGPSMYSPLLSGGLPTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>Q5BGZ4</accession>
    <accession>C8VUX7</accession>
    <name>Q5BGZ4_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_00186</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF90017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_657790.1">
        <property type="nucleotide sequence ID" value="XM_652698.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5BGZ4"/>
    <dbReference type="STRING" id="227321.Q5BGZ4"/>
    <dbReference type="GeneID" id="2875964"/>
    <dbReference type="KEGG" id="ani:ANIA_00186"/>
    <dbReference type="eggNOG" id="ENOG502S621">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047721_1_0_1"/>
    <dbReference type="InParanoid" id="Q5BGZ4"/>
    <dbReference type="OMA" id="RVHRTCH"/>
    <dbReference type="OrthoDB" id="5370011at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF90017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="335" mass="37850" checksum="6949CB1189234AD2" modified="2005-04-26" version="1">MSTSQSDGKQEGLAKVLSRMKTVLRRTPSRATTSTARETIAPVQPESSKAPAQPKSTPQPAKPAPEPTVVSHWSAIQEEKARALFAKYGLTLEPGEWKATSDVTVQRVVKPIRMRVRRTCHRCQTTFGPDKVCVNCQHVRCKNCPRYPAAKPKDKQEQTETALQAILAQKAQPVRPKPREHQLTLPSRSGGQDLIRKQPRQRLRRTCHRCNTLFAPHSTECSSCKHIRCKNCPRDPPKLDKYPDGYPGDAEPPYEPPARTWKKPRQRVRYTCHQCSTVYRSGEKNCANCGQEKCAETIRDPPKKIKPEPDPEIVRRVEERLANIRVSEGSETPKS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2022-05-25" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1U8QGV2</accession>
    <accession>C8VDU1</accession>
    <accession>Q5AV63</accession>
    <name>STCG_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">5'-hydroxyaverantin dehydrogenase stcG</fullName>
            <shortName evidence="3">HAVN dehydrogenase</shortName>
            <ecNumber evidence="3">1.1.1.352</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Sterigmatocystin biosynthesis cluster protein G</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">swtcG</name>
        <name type="ORF">AN7817</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="1994" name="Appl. Environ. Microbiol." volume="60" first="1444" last="1450">
            <title>Aspergillus nidulans verA is required for production of the mycotoxin sterigmatocystin.</title>
            <authorList>
                <person name="Keller N.P."/>
                <person name="Kantz N.J."/>
                <person name="Adams T.H."/>
            </authorList>
            <dbReference type="PubMed" id="8017929"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="1995" name="Appl. Environ. Microbiol." volume="61" first="3628" last="3632">
            <title>StcS, a putative P-450 monooxygenase, is required for the conversion of versicolorin A to sterigmatocystin in Aspergillus nidulans.</title>
            <authorList>
                <person name="Keller N.P."/>
                <person name="Segner S."/>
                <person name="Bhatnagar D."/>
                <person name="Adams T.H."/>
            </authorList>
            <dbReference type="PubMed" id="7486998"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="1995" name="J. Bacteriol." volume="177" first="4792" last="4800">
            <title>Sterigmatocystin biosynthesis in Aspergillus nidulans requires a novel type I polyketide synthase.</title>
            <authorList>
                <person name="Yu J.-H."/>
                <person name="Leonard T.J."/>
            </authorList>
            <dbReference type="PubMed" id="7642507"/>
        </citation>
        <scope>FUNCTION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="6">
        <citation type="journal article" date="1996" name="Appl. Environ. Microbiol." volume="62" first="4296" last="4298">
            <title>Aspergillus nidulans stcP encodes an O-methyltransferase that is required for sterigmatocystin biosynthesis.</title>
            <authorList>
                <person name="Kelkar H.S."/>
                <person name="Keller N.P."/>
                <person name="Adams T.H."/>
            </authorList>
            <dbReference type="PubMed" id="8900026"/>
            <dbReference type="DOI" id="10.1128/aem.62.11.4296-4298.1996"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="1996" name="Proc. Natl. Acad. Sci. U.S.A." volume="93" first="14873" last="14877">
            <title>Aspergillus has distinct fatty acid synthases for primary and secondary metabolism.</title>
            <authorList>
                <person name="Brown D.W."/>
                <person name="Adams T.H."/>
                <person name="Keller N.P."/>
            </authorList>
            <dbReference type="PubMed" id="8962148"/>
            <dbReference type="DOI" id="10.1073/pnas.93.25.14873"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="8">
        <citation type="journal article" date="1996" name="Proc. Natl. Acad. Sci. U.S.A." volume="93" first="1418" last="1422">
            <title>Twenty-five coregulated transcripts define a sterigmatocystin gene cluster in Aspergillus nidulans.</title>
            <authorList>
                <person name="Brown D.W."/>
                <person name="Yu J.-H."/>
                <person name="Kelkar H.S."/>
                <person name="Fernandes M."/>
                <person name="Nesbitt T.C."/>
                <person name="Keller N.P."/>
                <person name="Adams T.H."/>
                <person name="Leonard T.J."/>
            </authorList>
            <dbReference type="PubMed" id="8643646"/>
            <dbReference type="DOI" id="10.1073/pnas.93.4.1418"/>
        </citation>
        <scope>INDUCTION</scope>
        <scope>FUNCTION</scope>
        <scope>PATHWAY</scope>
    </reference>
    <reference key="9">
        <citation type="journal article" date="1997" name="J. Biol. Chem." volume="272" first="1589" last="1594">
            <title>Aspergillus nidulans stcL encodes a putative cytochrome P-450 monooxygenase required for bisfuran desaturation during aflatoxin/sterigmatocystin biosynthesis.</title>
            <authorList>
                <person name="Kelkar H.S."/>
                <person name="Skloss T.W."/>
                <person name="Haw J.F."/>
                <person name="Keller N.P."/>
                <person name="Adams T.H."/>
            </authorList>
            <dbReference type="PubMed" id="8999832"/>
            <dbReference type="DOI" id="10.1074/jbc.272.3.1589"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="10">
        <citation type="journal article" date="2000" name="Appl. Environ. Microbiol." volume="66" first="359" last="362">
            <title>Requirement of monooxygenase-mediated steps for sterigmatocystin biosynthesis by Aspergillus nidulans.</title>
            <authorList>
                <person name="Keller N.P."/>
                <person name="Watanabe C.M."/>
                <person name="Kelkar H.S."/>
                <person name="Adams T.H."/>
                <person name="Townsend C.A."/>
            </authorList>
            <dbReference type="PubMed" id="10618248"/>
            <dbReference type="DOI" id="10.1128/aem.66.1.359-362.2000"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="11">
        <citation type="journal article" date="2012" name="Metabolites" volume="2" first="100" last="133">
            <title>Genetics of polyketide metabolism in Aspergillus nidulans.</title>
            <authorList>
                <person name="Klejnstrup M.L."/>
                <person name="Frandsen R.J."/>
                <person name="Holm D.K."/>
                <person name="Nielsen M.T."/>
                <person name="Mortensen U.H."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen J.B."/>
            </authorList>
            <dbReference type="PubMed" id="24957370"/>
            <dbReference type="DOI" id="10.3390/metabo2010100"/>
        </citation>
        <scope>REVIEW ON STERIGMATOCYSTIN BIOSYNTHESIS</scope>
    </reference>
    <comment type="function">
        <text evidence="4 6 7 9 10 11 12 13 17">5'-hydroxyaverantin dehydrogenase; part of the gene cluster that mediates the biosynthesis of sterigmatocystin (ST), a polyketide-derived furanocoumarin which is part of the most toxic and carcinogenic compounds among the known mycotoxins (PubMed:8643646). The first step in the biosynthesis of sterigmatocystin is the production of hexanoate by the fatty acid synthase (FAS) units stcJ and stcK (PubMed:8962148). The polyketide backbone is assembled by the non-reducing polyketide synthase stcA by condensation of the starter hexanoyl-CoA and 7 malonyl-CoA extender units followed by cyclization and release of norsolorinic acid (By similarity). Norsolorinic acid is the first stable intermediate in the biosynthesis of sterigmatocystin and is converted into averantin (AVN) by the ketoreductase stcE which reduces the hexanoate ketone to an alcohol (Probable) (PubMed:8643646). Averantin is then oxidized into 5'-hydroxyaverantin (HAVN) by the cytochrome P450 monooxygenase stcF (PubMed:10618248). 5'-hydroxyaverantin is further converted to 5'-oxyaverantin (OAVN) by the 5'-hydroxyaverantin dehydrogenase stcG (PubMed:24957370). The next step is the conversion of OAVN into averufin (AVF) which is catalyzed by a yet to be identified enzyme (PubMed:24957370). The cytochrome P450 monooxygenase stcB and the flavin-binding monooxygenase stcW are both required for the conversion of averufin to 1-hydroxyversicolorone (PubMed:10618248). The esterase stcI probably catalyzes the formation of versiconal hemiacetal acetate from 1-hydroxyversicolorone (PubMed:24957370). The oxydoreductase stcN then probably catalyzes the biosynthetic step from versiconal to versicolorin B (VERB) (PubMed:24957370). The next step is performed by the versicolorin B desaturase stcL to produce versicolorin A (VERA) (PubMed:8999832). The ketoreductase stcU and the cytochrome P450 monooxygenase stcS are involved in the conversion of versicolorin A to demethylsterigmatocystin (PubMed:7486998). The Baeyer-Villiger oxidas stcQ and the reductase stcR might be involved in the biosynthetic step from versicolorin A to demethylsterigmatocystin (PubMed:24957370). The final step in the biosynthesis of sterigmatocystin is the methylation of demethylsterigmatocystin catalyzed by the methyltransferase stcP (PubMed:8900026).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>(1'S,5'S)-5'-hydroxyaverantin + NAD(+) = (S)-5'-oxoaverantin + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:35475"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:77900"/>
            <dbReference type="ChEBI" id="CHEBI:77933"/>
            <dbReference type="EC" id="1.1.1.352"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>(1'S,5'R)-5'-hydroxyaverantin + NAD(+) = (S)-5'-oxoaverantin + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:35479"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:71536"/>
            <dbReference type="ChEBI" id="CHEBI:77933"/>
            <dbReference type="EC" id="1.1.1.352"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="9">Mycotoxin biosynthesis; sterigmatocystin biosynthesis.</text>
    </comment>
    <comment type="induction">
        <text evidence="8 9">The genes forming the sterigmatocystin biosynthesis cluster are co-regulated and induced on oatmeal porridge or the fungal isolates were grown either on oatmeal porridge or in YEC medium (0.2% yeast extract, 5.0% corn steep liquor).</text>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.352" evidence="3"/>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF80169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AACD01000132">
        <property type="protein sequence ID" value="EAA61605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_681086.1">
        <property type="nucleotide sequence ID" value="XM_675994.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1U8QGV2"/>
    <dbReference type="SMR" id="A0A1U8QGV2"/>
    <dbReference type="STRING" id="227321.Q5AV63"/>
    <dbReference type="EnsemblFungi" id="CBF80169">
        <property type="protein sequence ID" value="CBF80169"/>
        <property type="gene ID" value="ANIA_07817"/>
    </dbReference>
    <dbReference type="KEGG" id="ani:ANIA_07817"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN7817"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_13_3_1"/>
    <dbReference type="OMA" id="AVYNTCY"/>
    <dbReference type="OrthoDB" id="5371740at2759"/>
    <dbReference type="UniPathway" id="UPA00377"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008670">
        <property type="term" value="F:2,4-dienoyl-CoA reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140396">
        <property type="term" value="F:5'-hydroxyaverantin dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
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    <dbReference type="GO" id="GO:0045461">
        <property type="term" value="P:sterigmatocystin biosynthetic process"/>
        <property type="evidence" value="ECO:0000270"/>
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        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
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        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
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    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43658:SF8">
        <property type="entry name" value="17-BETA-HYDROXYSTEROID DEHYDROGENASE 14-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43658">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-0521">NADP</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000455265" description="5'-hydroxyaverantin dehydrogenase stcG">
        <location>
            <begin position="1"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <feature type="active site" description="Lowers pKa of active site Tyr" evidence="2">
        <location>
            <position position="190"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="L0E2Z4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="O93868"/>
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    </evidence>
    <evidence type="ECO:0000250" key="3">
        <source>
            <dbReference type="UniProtKB" id="P87017"/>
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    </evidence>
    <evidence type="ECO:0000250" key="4">
        <source>
            <dbReference type="UniProtKB" id="Q12053"/>
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            <dbReference type="PROSITE-ProRule" id="PRU10001"/>
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            <dbReference type="PubMed" id="10618248"/>
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            <dbReference type="PubMed" id="7486998"/>
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            <dbReference type="PubMed" id="8643646"/>
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            <dbReference type="PubMed" id="8900026"/>
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        <source>
            <dbReference type="PubMed" id="8962148"/>
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        <source>
            <dbReference type="PubMed" id="8999832"/>
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    </evidence>
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        <source>
            <dbReference type="PubMed" id="24957370"/>
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    </evidence>
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        <source>
            <dbReference type="PubMed" id="8643646"/>
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    </evidence>
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        <source>
            <dbReference type="PubMed" id="8900026"/>
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    </evidence>
    <evidence type="ECO:0000305" key="16"/>
    <evidence type="ECO:0000305" key="17">
        <source>
            <dbReference type="PubMed" id="8643646"/>
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    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EAA61605.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000005890"/>
        </source>
    </evidence>
    <sequence length="305" mass="32640" checksum="2DC794D0F5432708" modified="2017-05-10" version="1">MEPLDLTCDLTSLNGKSAFITGGASGLGLATARKWAEAGVYITIADIQPPTSPVQPGLAHCFHYVYCDVTSWESQVAAFKSALRFSPSGALDIVACFAGTALAPGNQIDHVLAAGVPSLEVDPPRPSSSVRNIEVNLVGSYFTSWLGLYYLRIPGTGTDPELPSNKCLLFCASIAAYMDSPKASTYPASKFGVRGLFRSTRSQTKQLGVRCNLLAPWFFDSPLIAPIKHAMAARGVDMAKVLTFTSIDACVDAATYCVASPEIHGRALAVQPEGTFDLKDDLEDGWGGNQLRPIMQRRRDAGFDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>C8V0C1</accession>
    <name>C8V0C1_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">SUMO ligase SizA, putative (AFU_orthologue AFUA_6G05240)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">ANIA_10822</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="16">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein sumoylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIAS family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF70854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467104.1">
        <property type="nucleotide sequence ID" value="XM_050612892.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V0C1"/>
    <dbReference type="FunCoup" id="C8V0C1">
        <property type="interactions" value="210"/>
    </dbReference>
    <dbReference type="STRING" id="227321.C8V0C1"/>
    <dbReference type="GeneID" id="2870234"/>
    <dbReference type="KEGG" id="ani:ANIA_10822"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN10822"/>
    <dbReference type="eggNOG" id="KOG2169">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020537_1_0_1"/>
    <dbReference type="InParanoid" id="C8V0C1"/>
    <dbReference type="OMA" id="TPIVECK"/>
    <dbReference type="OrthoDB" id="28127at2759"/>
    <dbReference type="UniPathway" id="UPA00886"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061665">
        <property type="term" value="F:SUMO ligase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019789">
        <property type="term" value="F:SUMO transferase activity"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097240">
        <property type="term" value="P:chromosome attachment to the nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="CDD" id="cd16792">
        <property type="entry name" value="SP-RING_Siz-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.780:FF:000003">
        <property type="entry name" value="MIZ zinc finger protein, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000247">
        <property type="entry name" value="Uncharacterized protein, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.780">
        <property type="entry name" value="PINIT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023321">
        <property type="entry name" value="PINIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038654">
        <property type="entry name" value="PINIT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031141">
        <property type="entry name" value="SIZ1/2_SP-RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004181">
        <property type="entry name" value="Znf_MIZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10782:SF100">
        <property type="entry name" value="LIGASE SIZA, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G05240)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10782">
        <property type="entry name" value="ZINC FINGER MIZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14324">
        <property type="entry name" value="PINIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02891">
        <property type="entry name" value="zf-MIZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51466">
        <property type="entry name" value="PINIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51044">
        <property type="entry name" value="ZF_SP_RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SAP" evidence="12">
        <location>
            <begin position="16"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="PINIT" evidence="14">
        <location>
            <begin position="106"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="SP-RING-type" evidence="13">
        <location>
            <begin position="292"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="382"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="435"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="471"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CBF70854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="504" mass="55877" checksum="3572EEB71FE40DF1" modified="2009-11-03" version="1">MASGQTSELQSVIALVKTLTNAQLKDILRDEGLAVSGLKAALQVRIINALEGHFQAGRLGRYDSLRKFIYATAHRSMPPSPSIPPPVPGNYYQQIPTTHSVQSHHRQSPLGMPVASHGSVPGPLIFKDSPFYRIIRQLTPTIECKAREHTRDSVELKIHLDADVASRLLAEPKLRVMIFCAADSGLNQFTKSDIAFPHQVELKANLDEVKANLRGLKNKPGTTRPADITNYIRKKAGYTNHVVMTYALTQKRFFIVANLVECTAIEELVDKLKRRKTITREQVLQEMKSKAEDADIVATSTVMSLKCPLSTRRIEVPCRSVLCTHNQCFDASSFLQLQEQAPTWSCPVCAKATSYESLNVDQYVDDILRSTPLDVEQVIIEPNGQWSTPKDEAVATGPGTFTPATDDDELVEIREPGVTPVKQENLSSLDLWRQTPATSREQSSAWSSSKRPAPVIDLTGSDDDDDSPIRPPKRQAVHLHRPLPKQDPRSSYTGGYPLPTFGSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2025-10-08" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>C8V1P8</accession>
    <name>C8V1P8_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">precorrin-2 dehydrogenase</fullName>
            <ecNumber evidence="2">1.3.1.76</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ANIA_06710</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>precorrin-2 + NAD(+) = sirohydrochlorin + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:15613"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58351"/>
            <dbReference type="ChEBI" id="CHEBI:58827"/>
            <dbReference type="EC" id="1.3.1.76"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Porphyrin-containing compound metabolism; siroheme biosynthesis; sirohydrochlorin from precorrin-2: step 1/1.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.76" evidence="2"/>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF71298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_664314.2">
        <property type="nucleotide sequence ID" value="XM_659222.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V1P8"/>
    <dbReference type="FunCoup" id="C8V1P8">
        <property type="interactions" value="108"/>
    </dbReference>
    <dbReference type="STRING" id="227321.C8V1P8"/>
    <dbReference type="GeneID" id="2870371"/>
    <dbReference type="KEGG" id="ani:ANIA_06710"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN6710"/>
    <dbReference type="eggNOG" id="ENOG502RYIW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011276_8_5_1"/>
    <dbReference type="InParanoid" id="C8V1P8"/>
    <dbReference type="OMA" id="TQIWKLC"/>
    <dbReference type="OrthoDB" id="1721126at2759"/>
    <dbReference type="UniPathway" id="UPA00262">
        <property type="reaction ID" value="UER00222"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004325">
        <property type="term" value="F:ferrochelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043115">
        <property type="term" value="F:precorrin-2 dehydrogenase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019354">
        <property type="term" value="P:siroheme biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.110">
        <property type="entry name" value="Siroheme synthase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3280.10">
        <property type="entry name" value="Siroheme synthase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028161">
        <property type="entry name" value="Met8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028162">
        <property type="entry name" value="Met8_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028281">
        <property type="entry name" value="Sirohaem_synthase_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006367">
        <property type="entry name" value="Sirohaem_synthase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01470">
        <property type="entry name" value="cysG_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35330">
        <property type="entry name" value="SIROHEME BIOSYNTHESIS PROTEIN MET8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35330:SF1">
        <property type="entry name" value="SIROHEME BIOSYNTHESIS PROTEIN MET8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13241">
        <property type="entry name" value="NAD_binding_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14823">
        <property type="entry name" value="Sirohm_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14824">
        <property type="entry name" value="Sirohm_synth_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75615">
        <property type="entry name" value="Siroheme synthase middle domains-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Siroheme synthase central" evidence="8">
        <location>
            <begin position="131"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="Siroheme biosynthesis protein Met8 C-terminal" evidence="7">
        <location>
            <begin position="160"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF14824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBF71298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="242" mass="26385" checksum="05DB1B70499C8350" modified="2009-11-03" version="1">MASKFPEVQGGGSLIVAWQVKEKNILVVGGGEVAAGRILHALNADAKVTVVCPASGLNDEVAYRVLEGQVTHIDRNFEPSDLDGADMVLCAIDDPEASTKIWKLCKEKRIPANIADVPSECDFYFGSVHRDGPLQVMVSTNGNGPKLASMVRKKIADTLPTNMGAAIENVGKLRQKLREVAPSPQEGRKRMKWMSAICESWRLEDLVHMTEEDMETLLTHYQHGGIPTLGEIRSSLPPPSTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>C8V1T1</accession>
    <name>C8V1T1_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">INO80 complex subunit F domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ANIA_10785</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF69932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050466968.1">
        <property type="nucleotide sequence ID" value="XM_050611628.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V1T1"/>
    <dbReference type="STRING" id="227321.C8V1T1"/>
    <dbReference type="GeneID" id="74896601"/>
    <dbReference type="KEGG" id="ani:ANIA_10785"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN10785"/>
    <dbReference type="eggNOG" id="KOG0381">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092538_0_0_1"/>
    <dbReference type="InParanoid" id="C8V1T1"/>
    <dbReference type="OMA" id="NEMMRMR"/>
    <dbReference type="OrthoDB" id="10070927at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056513">
        <property type="entry name" value="INO80F"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24245">
        <property type="entry name" value="INO80F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="INO80 complex subunit F" evidence="4">
        <location>
            <begin position="20"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="95"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="177"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="193"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="229"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBF69932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="238" mass="26094" checksum="60774E112BDB5047" modified="2009-11-03" version="1">MESRTTSQPSTNPPSIEIAYKRKCIALKKRLSEIEAENELMRTRNRRGWQYIQKMRLESCILLERLATVTGMAEEAQAGVNPELRARAAAMVTNTASLDGMAPPRNGSGPGYYEDETEGSSDEQPPTPQERPLRVKRSRKSNLPIDDDDLPAGTTPETSGAGASSAWPRLAPAPSQEEMTSSFRIQQGNGSGQEKETPLPSDREGENRYVSGERAVDPSAETSATPMELDNKVLKEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>C8V1V6</accession>
    <name>C8V1V6_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_10853</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
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                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
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                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
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            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
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        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
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</entry>
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    <accession>C8V2Z6</accession>
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        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
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            <taxon>Eurotiomycetidae</taxon>
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        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
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            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
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            <begin position="1"/>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
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        <source>
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    <sequence length="58" mass="6537" checksum="6F875D41F967F06A" modified="2009-11-03" version="1">MQLQLRLQQRLQNPSPAGRTSAGPLIRDSYGTYSVATMDVRLDRPEIAPRYSVLYGDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
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    <name>C8V3H1_EMENI</name>
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        <submittedName>
            <fullName evidence="3">Cold shock NA binding domain protein (JCVI)</fullName>
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        <name evidence="3" type="ORF">ANIA_10761</name>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF70506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467041.1">
        <property type="nucleotide sequence ID" value="XM_050612390.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V3H1"/>
    <dbReference type="STRING" id="227321.C8V3H1"/>
    <dbReference type="GeneID" id="74896589"/>
    <dbReference type="KEGG" id="ani:ANIA_10761"/>
    <dbReference type="HOGENOM" id="CLU_2158349_0_0_1"/>
    <dbReference type="InParanoid" id="C8V3H1"/>
    <dbReference type="OMA" id="QFGTIEW"/>
    <dbReference type="OrthoDB" id="422005at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04458">
        <property type="entry name" value="CSP_CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSD" evidence="2">
        <location>
            <begin position="46"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF70506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="111" mass="12110" checksum="A044998BFF2625BE" modified="2009-11-03" version="1">MSDTSASVSLPLHTKSPSSSTSSSSTPAQAKEQPKMPVAAPASPNRQFGTVKWYNDAQGFGFITSDFGGELILRRQSITEHTQRLKEGMKVSYEAVHLPMLLMAEQVQPEE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2018-05-23" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>C8V3N0</accession>
    <accession>Q5AV08</accession>
    <name>ATNN_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Aspercryptin biosynthesis cluster-specific transcription regulator atnN</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Aspercryptin biosynthesis cluster protein N</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">atnN</name>
        <name type="ORF">ANIA_07872</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="Proc. Natl. Acad. Sci. U.S.A." volume="110" first="E99" last="E107">
            <title>Accurate prediction of secondary metabolite gene clusters in filamentous fungi.</title>
            <authorList>
                <person name="Andersen M.R."/>
                <person name="Nielsen J.B."/>
                <person name="Klitgaard A."/>
                <person name="Petersen L.M."/>
                <person name="Zachariasen M."/>
                <person name="Hansen T.J."/>
                <person name="Blicher L.H."/>
                <person name="Gotfredsen C.H."/>
                <person name="Larsen T.O."/>
                <person name="Nielsen K.F."/>
                <person name="Mortensen U.H."/>
            </authorList>
            <dbReference type="PubMed" id="23248299"/>
            <dbReference type="DOI" id="10.1073/pnas.1205532110"/>
        </citation>
        <scope>IDENTIFICATION OF THE CLUSTER</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2016" name="ACS Chem. Biol." volume="11" first="2117" last="2123">
            <title>New aspercryptins, lipopeptide natural products, revealed by HDAC inhibition in Aspergillus nidulans.</title>
            <authorList>
                <person name="Henke M.T."/>
                <person name="Soukup A.A."/>
                <person name="Goering A.W."/>
                <person name="McClure R.A."/>
                <person name="Thomson R.J."/>
                <person name="Keller N.P."/>
                <person name="Kelleher N.L."/>
            </authorList>
            <dbReference type="PubMed" id="27310134"/>
            <dbReference type="DOI" id="10.1021/acschembio.6b00398"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2016" name="Angew. Chem. Int. Ed." volume="55" first="1662" last="1665">
            <title>Development of genetic dereplication strains in Aspergillus nidulans results in the discovery of aspercryptin.</title>
            <authorList>
                <person name="Chiang Y.M."/>
                <person name="Ahuja M."/>
                <person name="Oakley C.E."/>
                <person name="Entwistle R."/>
                <person name="Asokan A."/>
                <person name="Zutz C."/>
                <person name="Wang C.C."/>
                <person name="Oakley B.R."/>
            </authorList>
            <dbReference type="PubMed" id="26563584"/>
            <dbReference type="DOI" id="10.1002/anie.201507097"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2024" name="Fungal Biol." volume="128" first="2311" last="2316">
            <title>Could the transcription factor AtnN coordinating the aspercryptin secondary metabolite gene cluster in Aspergillus nidulans be a global regulator?</title>
            <authorList>
                <person name="Kocsis B."/>
                <person name="Boldizsar I."/>
                <person name="Kovacs G.M."/>
                <person name="Nagy T."/>
                <person name="Gyemant G."/>
                <person name="Csillag K."/>
                <person name="Pocsi I."/>
                <person name="Leiter E."/>
            </authorList>
            <dbReference type="PubMed" id="39643398"/>
            <dbReference type="DOI" id="10.1016/j.funbio.2024.11.006"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="function">
        <text evidence="3 4 8">Transcription factor that positively regulates the cluster that mediates the production of aspercryptins, linear lipopeptides built from six amino acids including 2 highly unusual and nonproteogenic amino acids, 2-amino-octanoic acid (2aoa) and 2-amino-dodecanol (2adol) (Probable) (PubMed:27310134). Positively regulates the formation of cleistothecia (PubMed:39643398). Negatively regulates the production of the extracellular triacetylfusarinine C (TAFC) while it positively regulates the production of the intracellular ferricrocin (FC) (PubMed:39643398). Also negatively regulates the production of asperthecin and sterigmatocystin (PubMed:39643398).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="4">Leads to higher sensitivity to tert-butyl hydroperoxide (tBOOH), and decreases cleistothecia formation (PubMed:39643398). Affects the synthesis of several secondary metabolites including the siderophores triacetylfusarinine C (TAFC) and ferricrocin (FC), as well as asperthecin and sterigmatocystin (PubMed:39643398).</text>
    </comment>
    <comment type="sequence caution" evidence="7">
        <conflict type="erroneous gene model prediction">
            <sequence resource="EMBL-CDS" id="EAA58917" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF73428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AACD01000134">
        <property type="protein sequence ID" value="EAA58917.1"/>
        <property type="status" value="ALT_SEQ"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V3N0"/>
    <dbReference type="SMR" id="C8V3N0"/>
    <dbReference type="EnsemblFungi" id="CBF73428">
        <property type="protein sequence ID" value="CBF73428"/>
        <property type="gene ID" value="ANIA_07872"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AN7872"/>
    <dbReference type="eggNOG" id="ENOG502SQ3E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_366813_0_0_1"/>
    <dbReference type="InParanoid" id="C8V3N0"/>
    <dbReference type="OMA" id="CRSTGRK"/>
    <dbReference type="OrthoDB" id="2593732at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052360">
        <property type="entry name" value="Transcr_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206:SF12">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000444133" description="Aspercryptin biosynthesis cluster-specific transcription regulator atnN">
        <location>
            <begin position="1"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Zn(2)-C6 fungal-type" evidence="1">
        <location>
            <begin position="30"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="427"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="66"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="437"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="27310134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="39643398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="5">
        <source>
            <dbReference type="PubMed" id="26563584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="6">
        <source>
            <dbReference type="PubMed" id="27310134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="7"/>
    <evidence type="ECO:0000305" key="8">
        <source>
            <dbReference type="PubMed" id="26563584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBF73428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="610" mass="68177" checksum="A64AA9ECF4281164" modified="2009-11-03" version="1">MAPKDSQVSASNEMTGNPPSSVQGRSRNGCITCRIRRVKCDEERPHCRRCQSTGRKCDGYTPLTGQQPKQQPPQQAAKAGSSELRIIQHTPQVTQPTQLCMFPGVDTLLTEDEYRALEFFNVQTVSCFGPRAGGWLLNAACQDSAIRRAAMALGTMHRVVLYHSRTPPHDRRRGMQLALQQYNSAIRQGLKLFAGSNDSSADGILSMCVLFFCLDSLQGHFRSALRHVGSGLRILAQRQLRGQRAENTLLPPDVIQSLFAALEAQMLEIDGQSPLLDENGLPVRGAGRPAPLWTLEEAQDTFRSIYNDFLRLLSFSARLEEPVDELEMVQIVEQVMARKQQVQTDLDAWSLEFDHFLAHIFHWGNQASQQSVRMLQLWRTMLTMVLHMGWPPQDTAWGSHLSELNIILDLAEQIIVMSPPLELESSAGSTFSLQGHSRAGSPSGSRSRSMSTSSSASRDDSPTTTTTTTTTPTPRLKKETDPQSTYTPILPRPFHSSPSRFTLALGILPALWTIATQCRDSSVRYRAIDLIGRSKRREGVWDSDLHFRLALQLARHEEQAAGLDAGAEYTHARIPPEARVTLNGRFDEGRKAKISYIRENVRVGEEIFHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>C8V6T6</accession>
    <name>C8V6T6_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carboxyphosphonoenolpyruvate phosphonomutase, putative (AFU_orthologue AFUA_2G03820)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_03805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = pyruvate + succinate</text>
            <dbReference type="Rhea" id="RHEA:16809"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57429"/>
            <dbReference type="EC" id="4.1.3.30"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF75344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467446.1">
        <property type="nucleotide sequence ID" value="XM_050611414.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V6T6"/>
    <dbReference type="STRING" id="227321.C8V6T6"/>
    <dbReference type="GeneID" id="2873221"/>
    <dbReference type="KEGG" id="ani:ANIA_03805"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN3805"/>
    <dbReference type="eggNOG" id="KOG1260">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027389_3_0_1"/>
    <dbReference type="InParanoid" id="C8V6T6"/>
    <dbReference type="OMA" id="KAFFQVM"/>
    <dbReference type="OrthoDB" id="1923844at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046421">
        <property type="term" value="F:methylisocitrate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00377">
        <property type="entry name" value="ICL_PEPM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039556">
        <property type="entry name" value="ICL/PEPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018523">
        <property type="entry name" value="Isocitrate_lyase_ph_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42905">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42905:SF15">
        <property type="entry name" value="PHOSPHONOMUTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G03820)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13714">
        <property type="entry name" value="PEP_mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00161">
        <property type="entry name" value="ISOCITRATE_LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF75344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="236" mass="25244" checksum="A06D6DC6EF101E98" modified="2009-11-03" version="1">MRANAEMISNLSPSTPVISDADTGYGGPIMVARTTEQYARAGVAAFHLEDQVQTKRCGHLGGKILVDTDTYVTRIRAAVQARKRIDSDIVIIARTDALQVNGYEDSLARLRAAREAGADAGFLEGITSIEMARQVIADLKGWPLLLNMVEHGATPSITAAQARELGFRIIIFPFAALGPACKAIQEGMEKLKRDGIPGLDKEMTPQMLFRVCGLDESIKVDAAAGGAAFSSGVELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>C8V6W5</accession>
    <name>C8V6W5_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ANIA_11590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF73995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V6W5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN11590"/>
    <dbReference type="HOGENOM" id="CLU_3423295_0_0_1"/>
    <dbReference type="InParanoid" id="C8V6W5"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF73995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="23" mass="2685" checksum="D5BCC7CAC34E1599" modified="2009-11-03" version="1">MASLATNKWYLRYLQEVANGNLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>C8V7I2</accession>
    <name>C8V7I2_EMENI</name>
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        <recommendedName>
            <fullName evidence="3">H/ACA ribonucleoprotein complex subunit NOP10</fullName>
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        <alternativeName>
            <fullName evidence="8">Nucleolar protein 10</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Nucleolar protein family A member 3</fullName>
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        <alternativeName>
            <fullName evidence="10">snoRNP protein NOP10</fullName>
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    </protein>
    <gene>
        <name evidence="11" type="ORF">ANIA_08254</name>
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    <organism evidence="11 12">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOP10 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF74217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_681523.2">
        <property type="nucleotide sequence ID" value="XM_676431.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V7I2"/>
    <dbReference type="FunCoup" id="C8V7I2">
        <property type="interactions" value="1255"/>
    </dbReference>
    <dbReference type="STRING" id="227321.C8V7I2"/>
    <dbReference type="GeneID" id="2869306"/>
    <dbReference type="KEGG" id="ani:ANIA_08254"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN8254"/>
    <dbReference type="eggNOG" id="KOG3503">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_184680_2_0_1"/>
    <dbReference type="InParanoid" id="C8V7I2"/>
    <dbReference type="OMA" id="HRIIIKK"/>
    <dbReference type="OrthoDB" id="13807at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
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    <dbReference type="GO" id="GO:0031429">
        <property type="term" value="C:box H/ACA snoRNP complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070034">
        <property type="term" value="F:telomerase RNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031118">
        <property type="term" value="P:rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031120">
        <property type="term" value="P:snRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="entry name" value="H/ACA ribonucleoprotein complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.80.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007264">
        <property type="entry name" value="H/ACA_rnp_Nop10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036756">
        <property type="entry name" value="H/ACA_rnp_Nop10_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13305:SF0">
        <property type="entry name" value="H_ACA RIBONUCLEOPROTEIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13305">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN NOP10"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Nop10p"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Nop10-like SnoRNP"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
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        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031779"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00032266"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="CBF74217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
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    </evidence>
    <sequence length="67" mass="7733" checksum="6B36E5D4942D3A00" modified="2009-11-03" version="1">MHLMYTLDQDGKRVYTLKKVTPTGEVTKSAHPARFSPDDKYSRHRVTLKKRYGLLLTQQADKEAAQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
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        <name evidence="10" type="ORF">ANIA_05021</name>
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    <organism evidence="10 11">
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF76263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467571.1">
        <property type="nucleotide sequence ID" value="XM_050611554.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8V864"/>
    <dbReference type="STRING" id="227321.C8V864"/>
    <dbReference type="GeneID" id="2872819"/>
    <dbReference type="KEGG" id="ani:ANIA_05021"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN5021"/>
    <dbReference type="eggNOG" id="KOG0853">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011001_2_0_1"/>
    <dbReference type="InParanoid" id="C8V864"/>
    <dbReference type="OMA" id="NAAAWMY"/>
    <dbReference type="OrthoDB" id="937291at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03792">
        <property type="entry name" value="GT4_trehalose_phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052078">
        <property type="entry name" value="Trehalose_Metab_GTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049438">
        <property type="entry name" value="TreT_GT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47779">
        <property type="entry name" value="SYNTHASE (CCG-9), PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12100)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47779:SF1">
        <property type="entry name" value="SYNTHASE (CCG-9), PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12100)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21269">
        <property type="entry name" value="TreT_GT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0313">Glucose metabolism</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Trehalose synthase N-terminal" evidence="9">
        <location>
            <begin position="247"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="8">
        <location>
            <begin position="468"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="11"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF21269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBF76263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="705" mass="79424" checksum="280D534809909C2C" modified="2009-11-03" version="1">MLPRLRDNLFDMLGGGSPSPRRASLQQKRRLSTEHSPNSWGAATTGNLYGGLSTVFEKDKVIFAVAIRDATYLVDFAQEELPFSESDDLDLKIGDHMMRHLYKWCDTHLEKMIGLAIPKQLAHTCPTICSRLWLELDIIPLVLSDNSKLDFRGEDLQYGFQQSADWELRTLDEQAESMARKCVRLFGPEGTPLLQVGLSGLVQVDTAFHVQLTNKDNYKNSVTANTWKAIEHYADDLRNRKVKLAFFSATPQGGGVALMRHAMVRFAHSIGTDMKWYVPKPRPGVFRITKTNHNILQGVSAPEERLTDENWEQVTNWIQENADRYWLRPGGPLEHPSKGGADVIVIDDPQMPALIPLAKQKAPERPVVFRSHIQIRSDLVDQDGSPQAECWGTMWKDIQKADIFVSHPVKSFVPKIVPREKVGYMPASTDWLDGLNKNMRNEDIAYYGRIFNSWVRNSGMPVIDYPADEYIVQIARFDPSKGIPHVIESYEKFHQRMQDYCPDKPIPKLLICGHGSVDDPDGSIIYDLAVRYIEDSIPDLADQICVVRLGPSDQVLNALMSKAKVALQLSTREGFEVKVSEAIHKGRPVIATRAGGIPLQVIDKGNGFLVDVGDTDAVAKHLFDLCTDDVLWKKMHEFALAHVCDEVSTVGNSLNWLYLASKLSKGGVIKPNERWLNDMAREDAGIPYQEGEDRLKRELEVQKMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>C8VAL8</accession>
    <name>C8VAL8_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RRM domain protein (AFU_orthologue AFUA_3G06890)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ANIA_04799</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRM CPSF6/7 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF76757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467629.1">
        <property type="nucleotide sequence ID" value="XM_050611620.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VAL8"/>
    <dbReference type="STRING" id="227321.C8VAL8"/>
    <dbReference type="GeneID" id="2872600"/>
    <dbReference type="KEGG" id="ani:ANIA_04799"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN4799"/>
    <dbReference type="eggNOG" id="KOG0118">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033916_1_1_1"/>
    <dbReference type="InParanoid" id="C8VAL8"/>
    <dbReference type="OMA" id="WNTDDDI"/>
    <dbReference type="OrthoDB" id="10065185at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110104">
        <property type="term" value="P:mRNA alternative polyadenylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd12372">
        <property type="entry name" value="RRM_CFIm68_CFIm59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034772">
        <property type="entry name" value="CPSF6/7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23204">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFIC FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="109"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="362"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="25"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="46"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="94"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBF76757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="391" mass="41645" checksum="BFFA407516FF1894" modified="2009-11-03" version="1">MATEDDNFDIDIYGDGSGYNANDQGDFKQDHDMKQEDTDLILDASDNAQNSGNSTDSGTIQQQPNVTTNGAPVTQSDTNNQQMQKDTTPQQGVKRKELDERPVDPDATPALLISELHWWTTDDDIRGWTREAGCEDELKDVTFSEHKVNGKSKGQAFLEFTSLPAATATKHHIDSLSTTGQSGRKFLVNYTSPIPNPFRTLPKDNPMRKDNARTGGFNSPNQNNANFGMGNMAGGFRGGRGGFNNRGGMSNMPGYVNRNFNNPMGGFNNPMVGAGFQGNQMAMGNYGFGGRGGMMGGNMRGGPGGMRGRGGGMAGGPNMMGMPNMGPMGGMGMNPMAGGMNPMMGGIGGNMGMQGGFQGPNQGFNTGFFPQNQGVGDGSWNPHGTKRSRQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>C8VAS4</accession>
    <name>C8VAS4_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ANIA_04750</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF76868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_662354.2">
        <property type="nucleotide sequence ID" value="XM_657262.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VAS4"/>
    <dbReference type="GeneID" id="2872553"/>
    <dbReference type="KEGG" id="ani:ANIA_04750"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN4750"/>
    <dbReference type="HOGENOM" id="CLU_064760_0_0_1"/>
    <dbReference type="InParanoid" id="C8VAS4"/>
    <dbReference type="OrthoDB" id="2123952at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF37">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="116"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="61"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBF76868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="365" mass="40954" checksum="60C6B151715ACD1A" modified="2009-11-03" version="1">MATRTSNSDARPRSQSGQGPSSLVRGVIDSEAQKMRCSRSQQRKQKSNPRRSEVLQNTSSHEVEHPNRRLKGANDPKLSRRQRNMKNLMMLNRLETNIGRLETRLLELGLDLDREGSVQSPRQLAVSDKPRSPSSLSIPGSENIVEEGLWRCGPCPEATLEDSGVPRTFPSMDREDDVPQNPEVNKSPFLDDFNGLLIPRCIMGGPADRKIPVLSREGLQWMNQKAGMTPRISSGIHSNATSFGILGDDFPKAFCPLPSKEEAESLLYQYLQNFNCLCPLFEQAKLTSLFNEDNLNTALRVPSCWASVNVVFALGIAFRVKDTRSVVYPGAPRDDRSWEVERGHYTILRRYATSEKNILDCVLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C8VAW3</accession>
    <name>C8VAW3_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">LCCL domain protein (AFU_orthologue AFUA_5G08630)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ANIA_10589</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF76944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467658.1">
        <property type="nucleotide sequence ID" value="XM_050611653.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VAW3"/>
    <dbReference type="FunCoup" id="C8VAW3">
        <property type="interactions" value="5"/>
    </dbReference>
    <dbReference type="GeneID" id="74896489"/>
    <dbReference type="KEGG" id="ani:ANIA_10589"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN10589"/>
    <dbReference type="eggNOG" id="ENOG502QUEX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011125_0_1_1"/>
    <dbReference type="InParanoid" id="C8VAW3"/>
    <dbReference type="OMA" id="HWDKTVL"/>
    <dbReference type="OrthoDB" id="441660at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.20">
        <property type="entry name" value="LCCL-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051957">
        <property type="entry name" value="CRISP-LCCL_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004043">
        <property type="entry name" value="LCCL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036609">
        <property type="entry name" value="LCCL_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31331:SF1">
        <property type="entry name" value="CYSTEINE RICH SECRETORY PROTEIN LCCL DOMAIN CONTAINING 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31331">
        <property type="entry name" value="LCCL DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G08630)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03815">
        <property type="entry name" value="LCCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00603">
        <property type="entry name" value="LCCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69848">
        <property type="entry name" value="LCCL domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50820">
        <property type="entry name" value="LCCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="304"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="358"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="426"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="459"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="LCCL" evidence="3">
        <location>
            <begin position="163"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBF76944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="660" mass="72747" checksum="CD6764260CADF3C6" modified="2009-11-03" version="1">MPSRSSSSSFERLSQHPDEYSLKSQDDSGSSQAVARNGRDSFDPAPAIREQSTSEPLLPTSNPHSVQQQKRFSCSVGGIWEWMRGPSPPHKYRINPWLGRWQTAPGRLIERYFHSTKTRFCLLSACLLLWGAAFISILHVSVAGQEIPGLGSPVKLSCSSRLWSNATNCGLDGDYCRPFDGETFAFRCPAGCSGFMVLEPYFVGPKEINYQHLVIGGAAAESQPDSVYRGDSSICQAAMHAGLLEDSKGGCGILRRTGEQKNFPAVDRNEISSVDFPSHFPLSFTFDTGASSEHSGLDCQDIRWPLFTFSVVVSTILSLVVASPAAFYASIFFIVYFQVALSSDPPYSPDYYEIVSTALGRFLPCAFVGFAIYHFCIRHTLSDLTAHWDKTILWLGPCWVGALNTDTFDKIPISRLTPHDIQQQPGAIPALIIIIVILVAIVITQALAFRNEGRMPKMLALYATLIAGIVILLLVPSMNLRIHHYILALLFLPGTTLQTRPSLLYQGLLVGLFINGIARWGFDSILQTSASLLDGAQLGSMLPYIPPDIITIPSGNPDIISFAFSSLRSLPSDIDGLSVIVNDVERYHAFRSDGAVDVRLPDLNWTRVVPGEPEYFRFGFIVENALGGFWYEDFTRPIVWDSDGRWNVSVSSSEGGRNSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>C8VBJ2</accession>
    <name>C8VBJ2_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_10968</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF79527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467972.1">
        <property type="nucleotide sequence ID" value="XM_050612008.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VBJ2"/>
    <dbReference type="GeneID" id="74896706"/>
    <dbReference type="KEGG" id="ani:ANIA_10968"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN10968"/>
    <dbReference type="HOGENOM" id="CLU_1845079_0_0_1"/>
    <dbReference type="InParanoid" id="C8VBJ2"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF79527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="139" mass="15446" checksum="DF69D66C041F4FEF" modified="2009-11-03" version="1">MPGRRAGPTGCQKRTGAGTELESFLQIPSNEPRKFRLEQSSASLLRRGSSLSFAARAIPFDSGFDSRIFNRLHKEIIKSRSWTLGWPTTATSSRMIHVAKARTKVEDRVCSVGARTKAMRHSLRPGPEYLPDGSSSRTR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2021-09-29" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>C8VBV0</accession>
    <name>PHHA_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">p-hydroxybenzoate-m-hydroxylase</fullName>
            <ecNumber evidence="8">1.14.13.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">4-hydroxybenzoate-3-monooxygenase phhA</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">FAD-dependent monooxygenase phhA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="ORF">ANIA_10952</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2015" name="Fungal Genet. Biol." volume="74" first="32" last="44">
            <title>The old 3-oxoadipate pathway revisited: new insights in the catabolism of aromatics in the saprophytic fungus Aspergillus nidulans.</title>
            <authorList>
                <person name="Martins T.M."/>
                <person name="Hartmann D.O."/>
                <person name="Planchon S."/>
                <person name="Martins I."/>
                <person name="Renaut J."/>
                <person name="Silva Pereira C."/>
            </authorList>
            <dbReference type="PubMed" id="25479309"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2014.11.002"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INDUCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="1 5 8">FAD-dependent monooxygenase; part of the benzoic acid degradation pathway also known as the protocatechuic acid pathway (PubMed:25479309). Benzoic acid debradation begins with the conversion of benzoic acid into 4-hydroxybenzoic acid through hydroxylation by the benzoate-4-monooxygenase bphA, and its partner NADPH-cytochrome P450 reductase cprA which act as a mediator in electron donation from NADPH (By similarity). 4-Hydroxybenzoic acid is then converted into 3,4-dihydroxybenzoic acid (also called protocatechuic acid) by the p-hydroxybenzoate-m-hydroxylase phhA (Probable). Protocatechuic acid is converted into 3-carboxy-cis,cis-muconic acid by the intradiol ring-cleavage dioxygenase prcA, which is further metabolized through the 3-oxoadipate pathway to finally enter the tricarboxylic acid cycle (TCA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>4-hydroxybenzoate + NADH + O2 + H(+) = 3,4-dihydroxybenzoate + NAD(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:19473"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17879"/>
            <dbReference type="ChEBI" id="CHEBI:36241"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.14.13.33"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:19474"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>4-hydroxybenzoate + NADPH + O2 + H(+) = 3,4-dihydroxybenzoate + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:19477"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17879"/>
            <dbReference type="ChEBI" id="CHEBI:36241"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.14.13.33"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:19478"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="2">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="5">Expression is largely up-regulated in the presence of benzoate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the PheA/TfdB FAD monooxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.33" evidence="8"/>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF79728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467995.1">
        <property type="nucleotide sequence ID" value="XM_050612034.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VBV0"/>
    <dbReference type="SMR" id="C8VBV0"/>
    <dbReference type="STRING" id="227321.C8VBV0"/>
    <dbReference type="EnsemblFungi" id="CBF79728">
        <property type="protein sequence ID" value="CBF79728"/>
        <property type="gene ID" value="ANIA_10952"/>
    </dbReference>
    <dbReference type="GeneID" id="74896695"/>
    <dbReference type="KEGG" id="ani:ANIA_10952"/>
    <dbReference type="eggNOG" id="KOG3855">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009665_9_3_1"/>
    <dbReference type="InParanoid" id="C8VBV0"/>
    <dbReference type="OMA" id="IMAYEPA"/>
    <dbReference type="OrthoDB" id="1716816at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018671">
        <property type="term" value="F:4-hydroxybenzoate 3-monooxygenase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd02979">
        <property type="entry name" value="PHOX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012941">
        <property type="entry name" value="Phe_hydrox_C_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038220">
        <property type="entry name" value="PHOX_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050641">
        <property type="entry name" value="RIFMO-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004:SF7">
        <property type="entry name" value="P-HYDROXYBENZOATE-M-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004">
        <property type="entry name" value="TRK SYSTEM POTASSIUM UPTAKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07976">
        <property type="entry name" value="Phe_hydrox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-0274">FAD</keyword>
    <keyword id="KW-0285">Flavoprotein</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0503">Monooxygenase</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000453617" description="p-hydroxybenzoate-m-hydroxylase">
        <location>
            <begin position="1"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="11"/>
            <end position="40"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="242"/>
            <end position="244"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="4">
        <location>
            <position position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="A2QTW5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="Q6SSJ6"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3"/>
    <evidence type="ECO:0000255" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="25479309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="6">
        <source>
            <dbReference type="PubMed" id="25479309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="7"/>
    <evidence type="ECO:0000305" key="8">
        <source>
            <dbReference type="PubMed" id="25479309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBF79728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="636" mass="71277" checksum="8DC5BBBB49DB809C" modified="2009-11-03" version="1">MTTDSYPKKYDIVIVGAGPVGILLSLCMSRWGYKVKHIDNRPVPTATGRADGIQPRSTEILRNLGLKRKIMAYDPAKVYDVSFWDPRPDGSGIMRTGNWPSCPRFIDTRYPFTTLVHQGKIETVFLDEIKKAGTTVERPWTIIGFKNDGLDATYPVQVQLKCLDTNVVETVRAKYLFSGEGARSFVREQLGIQIRHKDPISYVWGVMDGVVRTDFPDIQTKCTIHSDAGSIMVIPREDDMVRLYVQIASSSDPDFNPRKTATAEEVQNVAKKILKPYYIEWDRVEWYSVYPIGQGISEKYTLDERVFMGGDACHTHSPKAGQGMNTAFHDALNMAWKLHAVESGLAQRSILSTYETERKNIAETLLDFDNKYAALFSKRRPNAGEVGEAATAETGRSAEEDPFVKTFKDSCEFTSGYGVAYLPNIFNWDPSHPAKSPLFDVPGINLVTGKAFTPSTVTRLADSNFVHLEQEIPANGAFRIFIFAGRQSRSKKAIADFAANLEKERSFLSAYRRSDIGEISFFERHNPHSKLFTLCLIYAEKKNDIDMDSIPQILRDYRYHIYSDDIPDVRVPNATYAAHEKLGFDPEKGGVVVTRPDSHIACTVQLAEGSGTVDALNAYFGSFSTKPLGQEQASRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>C8VDD3</accession>
    <name>C8VDD3_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ANIA_10892</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Mediator complex subunit 27 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF79081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050467907.1">
        <property type="nucleotide sequence ID" value="XM_050611938.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VDD3"/>
    <dbReference type="STRING" id="227321.C8VDD3"/>
    <dbReference type="GeneID" id="2869814"/>
    <dbReference type="KEGG" id="ani:ANIA_10892"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN10892"/>
    <dbReference type="eggNOG" id="ENOG502SEH4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068932_0_0_1"/>
    <dbReference type="InParanoid" id="C8VDD3"/>
    <dbReference type="OMA" id="KQTPCVK"/>
    <dbReference type="OrthoDB" id="10254221at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021627">
        <property type="entry name" value="Mediator_Med27"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11571">
        <property type="entry name" value="Med27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
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        </location>
    </feature>
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    </feature>
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    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        <source>
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    </evidence>
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        <source>
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        <source>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="CBF79081.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
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<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>C8VDE3</accession>
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        <name evidence="3" type="ORF">ANIA_07093</name>
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        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
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        <lineage>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
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            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
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    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
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                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
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        <property type="nucleotide sequence ID" value="XM_050611943.1"/>
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    <dbReference type="GeneID" id="2869929"/>
    <dbReference type="KEGG" id="ani:ANIA_07093"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN7093"/>
    <dbReference type="eggNOG" id="ENOG502QUDU">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_804173_0_0_1"/>
    <dbReference type="InParanoid" id="C8VDE3"/>
    <dbReference type="OMA" id="WQHVNSS"/>
    <dbReference type="OrthoDB" id="3550957at2759"/>
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        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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    <dbReference type="GO" id="GO:0016020">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="P:conjugation with cellular fusion"/>
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        <property type="entry name" value="Dni1/Fig1"/>
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        <property type="entry name" value="FACTOR-INDUCED GENE 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28092:SF1">
        <property type="entry name" value="FACTOR-INDUCED GENE 1 PROTEIN"/>
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    </dbReference>
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        <property type="entry name" value="Fig1"/>
        <property type="match status" value="1"/>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
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            <end position="233"/>
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    </feature>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF79099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="345" mass="37712" checksum="0DDBFF7396F80B73" modified="2009-11-03" version="1">MEDSSQPETERTALGAQIPPLRFQNMHALQTPMHRILPTPSHPLLQKLRFHSEWRQRWTRGGSRTESEQLEGGAETAEETEHGQTEEKEEHEDNNGREEEEEEETLLVAGCSSNRMRAIYLLELSYQHDHREPGGEYRLSALNPSFYAMVSNLSSAGDLTIRVGYFGLCAAANSSGTTNWACRSTARDLGAQISTISDPLNILAIADNFRDEIILSVIIIMAIVLIFLSFSALSTFPGRYTDVDASGDEFEIKLLPATEVVYLVLSFDVLASLVLIVAVLWQHVAVVAHAATAEAAFGGAIKGDVGAVAMGLGWGAIGAVLLVTFGIAIQKLSRGELRLITDEED</sequence>
</entry>
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        <submittedName>
            <fullName evidence="3">MutT/nudix family protein (AFU_orthologue AFUA_5G08240)</fullName>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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        </lineage>
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    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF79954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468028.1">
        <property type="nucleotide sequence ID" value="XM_050612070.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VDH4"/>
    <dbReference type="FunCoup" id="C8VDH4">
        <property type="interactions" value="646"/>
    </dbReference>
    <dbReference type="STRING" id="227321.C8VDH4"/>
    <dbReference type="GeneID" id="2869650"/>
    <dbReference type="KEGG" id="ani:ANIA_07711"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN7711"/>
    <dbReference type="eggNOG" id="KOG3041">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062658_0_1_1"/>
    <dbReference type="InParanoid" id="C8VDH4"/>
    <dbReference type="OMA" id="NDPGLCN"/>
    <dbReference type="OrthoDB" id="10249920at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047631">
        <property type="term" value="F:ADP-ribose diphosphatase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006753">
        <property type="term" value="P:nucleoside phosphate metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019693">
        <property type="term" value="P:ribose phosphate metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd18888">
        <property type="entry name" value="NUDIX_ADPRase_Nudt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000016">
        <property type="entry name" value="ADP-sugar pyrophosphatase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11839:SF1">
        <property type="entry name" value="ADP-SUGAR PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11839">
        <property type="entry name" value="UDP/ADP-SUGAR PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="54"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF79954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="207" mass="23090" checksum="E6411FBC6B3ACE76" modified="2009-11-03" version="1">MSDPMYARSKFLSKGPLDPNEAKWTRLVKTTYCDPNGVERTWESAERQTRPANCEVDGVGIVTILDKSSGPELLLQKQYRPPIDKVVIEVPAGLIDPNETVEECAVRELKEETGYVGVADATSTVMYNDPGFCNTNLNMVHVRVDMSLPENQNPKPQLEDNEFIECFTLPLASLFDELKRLEAEGYAIDARIGTIAEGIELAKKLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C8VDX2</accession>
    <name>C8VDX2_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-CoA thioesterase (AFU_orthologue AFUA_1G12060)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_11027</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the C/M/P thioester hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF80225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468061.1">
        <property type="nucleotide sequence ID" value="XM_050612107.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VDX2"/>
    <dbReference type="STRING" id="227321.C8VDX2"/>
    <dbReference type="GeneID" id="74896738"/>
    <dbReference type="KEGG" id="ani:ANIA_11027"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN11027"/>
    <dbReference type="eggNOG" id="KOG3016">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051867_1_0_1"/>
    <dbReference type="InParanoid" id="C8VDX2"/>
    <dbReference type="OMA" id="NGYWTQA"/>
    <dbReference type="OrthoDB" id="68328at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006637">
        <property type="term" value="P:acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009062">
        <property type="term" value="P:fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd03444">
        <property type="entry name" value="Thioesterase_II_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03445">
        <property type="entry name" value="Thioesterase_II_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.210:FF:000018">
        <property type="entry name" value="Acyl-CoA thioesterase (AFU_orthologue AFUA_1G12060)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.210">
        <property type="entry name" value="Acyl-CoA thioesterase, double hotdog domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049450">
        <property type="entry name" value="ACOT8-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042171">
        <property type="entry name" value="Acyl-CoA_hotdog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003703">
        <property type="entry name" value="Acyl_CoA_thio"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11066">
        <property type="entry name" value="ACYL-COA THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11066:SF64">
        <property type="entry name" value="ACYL-COA THIOESTERASE (AFU_ORTHOLOGUE AFUA_1G12060)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20789">
        <property type="entry name" value="4HBT_3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA thioesterase-like C-terminal" evidence="2">
        <location>
            <begin position="221"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF80225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="330" mass="36108" checksum="5BA22D6C646F5A96" modified="2009-11-03" version="1">MPAIAPSEPPSFVQALHLEKLPAAGERYLSTFPALSYDYAPGKPLSVNRSYGGHAFAQAIWAASLGIRDSGLRIHEANGYWTLAGYANRPFLYEVKTLSITRSFALREVIARQPTTPSDECPFPKSDGDKELGPVAFALTCSFKQRESGPAYWLKFDANKYGNLLQQDPSSYLQDVYLKGPNGVGSIRLADFPSLDIRTPDLQEHSIKSPGTSHRRLHVYRASEALDLDPNLVAALHAYVSDRAGLSVLLNAFGATDLGISGSLSHKILFHVSPEKMAVDKRTWFTQEMSSSRGGEGRGVIDSRIWSPSGELVATTIQDALFRQPKAKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>C8VEI1</accession>
    <name>C8VEI1_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Zn(II)2Cys6 transcription factor (Eurofung)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ANIA_08469</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF80615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="XP_050468101.1">
        <property type="nucleotide sequence ID" value="XM_050612151.1"/>
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    <dbReference type="AlphaFoldDB" id="C8VEI1"/>
    <dbReference type="STRING" id="227321.C8VEI1"/>
    <dbReference type="GeneID" id="2868616"/>
    <dbReference type="KEGG" id="ani:ANIA_08469"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN8469"/>
    <dbReference type="eggNOG" id="ENOG502SI37">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013869_1_0_1"/>
    <dbReference type="InParanoid" id="C8VEI1"/>
    <dbReference type="OMA" id="ACILCQY"/>
    <dbReference type="OrthoDB" id="5418899at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
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    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
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        <property type="term" value="F:DNA-binding transcription factor activity"/>
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    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="F:transcription cis-regulatory region binding"/>
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        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF9">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="21"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="66"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBF80615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="571" mass="64433" checksum="1E3DFEBA9AA2820B" modified="2009-11-03" version="1">MTCHQSGIRSRTKGGARSRKGCPECRSRKIKCDEQTPQCGQCLKTGRVCRIVDSLFKPHSYTFLAQTSPEPKSRDARAVRAEDKDVDEGLTRKTNPLNGDHQINIKYAVAPKAVDSKPSEARTHPLYQDDRALTAETMTIPPLPKRVQTERVSLASMSKRPEDATTQAGETYHDRCETAFFLRHFCEGPGQWMDLCTDQSYFSQNVVAISDKSPLVRYAACALAAKQLGQTRHPESHIRQTNVQRSMMKALIDSKLGFTWYGAKYYEKAIQLLAQQLSSRDRGTYSRLPGHVYGVGTTNGQPACGNDEEMYAETISLTVDLVVTQRKTRVDPDDIVLWCKMGLPVDAYGNLLPETRHDGLFETILFKALIRLMCRLVNLDFGNATKWTLISEEYDRWQGAVPSSFYIPITWTPNGPNPGDSIDPCSRGNISRETWFANDICAMTVAFYHMSRIILLANRPNSIAVRPHGIENGLIATCNALQQELRKHALEIMAIVQAMPSERVQKYMLQPLYVAGRHLTDPQERSDILQMLRNMGDDFGLFTDYRIRDLCDEWGMECNGIDRRDGYGILT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C8VHB2</accession>
    <name>C8VHB2_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Nuclear pore complex protein An-Pom152 (Eurofung)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ANIA_03454</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF82674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_661058.2">
        <property type="nucleotide sequence ID" value="XM_655966.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VHB2"/>
    <dbReference type="FunCoup" id="C8VHB2">
        <property type="interactions" value="85"/>
    </dbReference>
    <dbReference type="STRING" id="227321.C8VHB2"/>
    <dbReference type="GeneID" id="2874092"/>
    <dbReference type="KEGG" id="ani:ANIA_03454"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN3454"/>
    <dbReference type="eggNOG" id="ENOG502QQ5B">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002415_0_0_1"/>
    <dbReference type="InParanoid" id="C8VHB2"/>
    <dbReference type="OMA" id="DRSNCKR"/>
    <dbReference type="OrthoDB" id="5529162at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070762">
        <property type="term" value="C:nuclear pore transmembrane ring"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006999">
        <property type="term" value="P:nuclear pore organization"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056541">
        <property type="entry name" value="Ig-like_POM152"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056542">
        <property type="entry name" value="Ig-like_POM152_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056543">
        <property type="entry name" value="Ig-like_POM152_9th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056544">
        <property type="entry name" value="Ig_POM152"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037701">
        <property type="entry name" value="Pom152"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056540">
        <property type="entry name" value="TMD_POM152"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28206">
        <property type="entry name" value="NUCLEOPORIN POM152"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28206:SF1">
        <property type="entry name" value="NUCLEOPORIN POM152"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24312">
        <property type="entry name" value="Ig-like_POM152"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24519">
        <property type="entry name" value="Ig-like_Pom152_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24527">
        <property type="entry name" value="Ig-like_Pom152_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23664">
        <property type="entry name" value="Ig_Pom152"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24097">
        <property type="entry name" value="TMD_POM152"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin POM152 N-terminal transmembrane" evidence="4">
        <location>
            <begin position="63"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin POM152 first Ig-like" evidence="6">
        <location>
            <begin position="198"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin POM152 Ig-like" evidence="5">
        <location>
            <begin position="452"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin POM152 immunoglobulin-like" evidence="3">
        <location>
            <begin position="557"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin POM152 Ig-like" evidence="5">
        <location>
            <begin position="759"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin POM152 immunoglobulin-like" evidence="3">
        <location>
            <begin position="873"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin POM152 ninth Ig-like" evidence="7">
        <location>
            <begin position="1072"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin POM152 Ig-like" evidence="5">
        <location>
            <begin position="1156"/>
            <end position="1244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="43"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF24519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF24527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBF82674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="1257" mass="140592" checksum="32D7635CAEBA0864" modified="2009-11-03" version="1">MSDTPRLRSAFPSTPQTTQKTRDYNRSPSRPIPRNAPRSKVVSQAPSADQDASSSLVPSSIIDPPTQRLYVAAAYVALNAWRFYEAWTASDDLDSTWLFLKWASIDGVFLFGLQALRIPWLEWAFPTTLALLLVHVAFNIFLMFRIPIPVGIWLSGMMRLAYDRELSISGQSIKPGDIINNASLILGKQIINILPEGSAVLNPELAPLCLDAQKTAVELPIRVNQTDPILIELLRLDFNNGDSEIVTIQSKQLKQLKRQSDKRRSQLSSELHRDLLLPIRKTGIYRLQRVVDESKLEVRVRASDSIVTACPRALIKNSHTHKCRGELSNLVLAVEGTPPLKIKYSRQVNDHDRGFSFQNIQPDHLRTPLLGHRSLGRLFDGREPDITWAKSQIIEIPLNESLNIGGDWLYMIEEVHDGSGNVANYSMVLEDLDRQSVKSLAQWHHFSVHEIPKLSLSGCNDQQFLEVARGESHPLPVKFHSTDHGYENDGPFSLIYSFGTDGQGSVDDSARTVRQLSLKSVDQKPMIKEPGWYSLKYVSSQFCSGEILEPSSCYLHNPPEPEISVRSEKIFDKCANNPVGLLVDLDLTGSPPFRLRYTIETSKGVETKHQIIDGLRAQLDFTPLEAGHYRYRFLDISDSVYGPRPLENKVAVLEQDVKPPASANFVGTPEVRKACFGEPISVDVAFHGEAPWTLQYELVHNGKKTRHVLESETARSTIITDNLVSGGGYNLVLTSVKDRSKCKRNLNEILKVDARSKPPHVSFGLVEKSRKYSALQGSKVDIPIRLSGERPWTLQYKNLDADASISTKTFWHENSFLTVSQEGRYELLGVTDSSCPGSVDDAAKVFEISWIPRPQITAVDNTPVGPDGLVAKNDICQGQGDSLELRLTGNPPYTIQCEQQRKGSRGSTAVRIRSLKTALHSLSMELETSEPGDYTYRFKEVGDNLYNNDPRGNQVVVTQKVNPLPSARFDAPGRIYGFCREDDSGDELIPLTMEGVPPFFLEISIKHYAKAKPEIVSIPNIKSNRHNLPIPRRHLDLGQHVVSIHKVRDARGCEKTYHTDPASVRVAVSDVPTIVPLESKTDYCVGERLSFSLSGHSPFEVFYTFNGVARRASSQTNHFRRIAEKPGVFTITAVSDGASGKCKAHKDIVKTIHPMPSVRISNGQVSIVDIHEGGEAKLEFEFWGTPPFEFTYIRSTNARKGKKAEIIDIKHDISYEHHKIIKTSDEGTYEVVAIKDKYCSFSTQPSMEKNEKLLTNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>C8VHG4</accession>
    <name>C8VHG4_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Phosphotransferase</fullName>
            <ecNumber evidence="11">2.7.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">ANIA_02638</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="15">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>D-fructose + ATP = D-fructose 6-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16125"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37721"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:16126"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a D-hexose + ATP = a D-hexose 6-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22740"/>
            <dbReference type="ChEBI" id="CHEBI:4194"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:229467"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:22741"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; hexose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the hexokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="11"/>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF84304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468576.1">
        <property type="nucleotide sequence ID" value="XM_050612685.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VHG4"/>
    <dbReference type="STRING" id="227321.C8VHG4"/>
    <dbReference type="GeneID" id="2873810"/>
    <dbReference type="KEGG" id="ani:ANIA_02638"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN2638"/>
    <dbReference type="eggNOG" id="KOG1369">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014393_5_2_1"/>
    <dbReference type="InParanoid" id="C8VHG4"/>
    <dbReference type="OMA" id="TNIRVCD"/>
    <dbReference type="OrthoDB" id="419537at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005536">
        <property type="term" value="F:D-glucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008865">
        <property type="term" value="F:fructokinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004340">
        <property type="term" value="F:glucokinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019158">
        <property type="term" value="F:mannokinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051156">
        <property type="term" value="P:glucose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001678">
        <property type="term" value="P:intracellular glucose homeostasis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000092">
        <property type="entry name" value="Phosphotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.367.20:FF:000004">
        <property type="entry name" value="Phosphotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.367.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001312">
        <property type="entry name" value="Hexokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022673">
        <property type="entry name" value="Hexokinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022672">
        <property type="entry name" value="Hexokinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443">
        <property type="entry name" value="HEXOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443:SF16">
        <property type="entry name" value="HEXOKINASE TYPE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00349">
        <property type="entry name" value="Hexokinase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03727">
        <property type="entry name" value="Hexokinase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00475">
        <property type="entry name" value="HEXOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51748">
        <property type="entry name" value="HEXOKINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="6 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hexokinase N-terminal" evidence="12">
        <location>
            <begin position="17"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="Hexokinase C-terminal" evidence="13">
        <location>
            <begin position="218"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CBF84304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="463" mass="51223" checksum="8DDE6A1EC0628D6A" modified="2009-11-03" version="1">MTVINEEAISLPILKEINNIKNQFKVDTVSLKHITDHFVRQLEDGLARYDGEIPMNVTWVPSFPTGHETGRYLAIDMGGTNLRICDVTLTEEKGAYTIEQDKYRLPIHLRKGKGVELWEFIAAKLEDFLAKHKLAREDGEKLPLAFTFSYPVTQDHIRHGVLQRWTKGFDISGVEGEDVVAHLEEVFEKRNVPVRLVALVNDTVGTLIASAYKNPAIKIGSIFATGCNAAYMEKVSRIPKIADHGSEFESDALVSINCEYGAFDNAHKVLPMTRFDEEIDQTSARPGQQAYEKMVAGMYMGELLRLLLLHLHESSGFFTDAEIDRLRGYGTMDSASLSRMEAGGSEAERMSDAKCILKDLYGIEATDEEARVCCLLGEIVCTRAARLYACGIAALCRKQGISECAVGVDGSTFEKYSQFRERAVDALGEILDWPEGQQLVKLVTAEDGSGVGSALIGAITLNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>C8VJB6</accession>
    <name>C8VJB6_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RNA exonuclease Rex2, putative (AFU_orthologue AFUA_3G11820)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ANIA_10348</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oligoribonuclease family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF83844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468514.1">
        <property type="nucleotide sequence ID" value="XM_050612608.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VJB6"/>
    <dbReference type="FunCoup" id="C8VJB6">
        <property type="interactions" value="729"/>
    </dbReference>
    <dbReference type="STRING" id="227321.C8VJB6"/>
    <dbReference type="GeneID" id="74896353"/>
    <dbReference type="KEGG" id="ani:ANIA_10348"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN10348"/>
    <dbReference type="eggNOG" id="KOG3242">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064761_3_1_1"/>
    <dbReference type="InParanoid" id="C8VJB6"/>
    <dbReference type="OMA" id="AFFHYRN"/>
    <dbReference type="OrthoDB" id="270189at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06135">
        <property type="entry name" value="Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000003">
        <property type="entry name" value="Oligoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022894">
        <property type="entry name" value="Oligoribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003765">
        <property type="entry name" value="PRK05359.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11046">
        <property type="entry name" value="OLIGORIBONUCLEASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11046:SF0">
        <property type="entry name" value="OLIGORIBONUCLEASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="5">
        <location>
            <begin position="9"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBF83844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="194" mass="21552" checksum="F18324B7CF5AC8FE" modified="2009-11-03" version="1">MPLTRSTDPLVWIDCEMTGLDPTTDHILQICCFITDADLNLLDATGFEAVIHVPQSALDSMSQWCIDTHGRTGLTQRVQNSTVTPEAAAADLLAYIKRYIPKPRTALLAGNSVHADKAFLACGPYAAILEWLHYRIVDVSTIKEVVRRWGGEGLLSAVPPKKEVHEAREDILESIEEMKFYKEQLFGASKLANK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>C8VJF2</accession>
    <name>C8VJF2_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DUF636 domain protein (AFU_orthologue AFUA_6G11530)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ANIA_10368</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF83908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468522.1">
        <property type="nucleotide sequence ID" value="XM_050612619.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VJF2"/>
    <dbReference type="GeneID" id="74896363"/>
    <dbReference type="KEGG" id="ani:ANIA_10368"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN10368"/>
    <dbReference type="HOGENOM" id="CLU_055491_3_6_1"/>
    <dbReference type="InParanoid" id="C8VJF2"/>
    <dbReference type="OMA" id="HIKSFCT"/>
    <dbReference type="OrthoDB" id="406544at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1590.10">
        <property type="entry name" value="glutathione-dependent formaldehyde- activating enzyme (gfa)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337:SF39">
        <property type="entry name" value="DUF636 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G11530)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337">
        <property type="entry name" value="GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="5">
        <location>
            <begin position="6"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBF83908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="141" mass="15702" checksum="072FBBDEC5C65704" modified="2009-11-03" version="1">MAEPTNSGSCLCGAVQYLLYGKPLNSAVCHCDSCQQFTGSAFVANCWYKEENVKLTRGHDSVQTYDEQGTTTGQIMKRSFCKTCGSSLFMQTAELRKQNVISVTSGTMDDRTDCQPGLEVWCANRRGWVTLNHQGVRLERQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>C8VK13</accession>
    <name>C8VK13_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_02715</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF84160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468562.1">
        <property type="nucleotide sequence ID" value="XM_050612667.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VK13"/>
    <dbReference type="FunCoup" id="C8VK13">
        <property type="interactions" value="26"/>
    </dbReference>
    <dbReference type="GeneID" id="2874409"/>
    <dbReference type="KEGG" id="ani:ANIA_02715"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN2715"/>
    <dbReference type="eggNOG" id="KOG1208">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044999_0_0_1"/>
    <dbReference type="InParanoid" id="C8VK13"/>
    <dbReference type="OMA" id="APHIYLI"/>
    <dbReference type="OrthoDB" id="2898509at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000637">
        <property type="entry name" value="Uncharacterized oxidoreductase C736.13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052228">
        <property type="entry name" value="Sec_Metab_Biosynth_Oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47534:SF2">
        <property type="entry name" value="KETOREDUCTASE (KR) DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47534">
        <property type="entry name" value="YALI0E05731P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF84160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="324" mass="35207" checksum="E01329DC934D279C" modified="2009-11-03" version="1">MVSFDQVKQTNSSLKSYGAGLVGVFVGGTSGIGEATARSFVRNATAPQVYLIGRNESQASKIIQELNALNPESKNTFLKCDVSLLKKVDEVCKEIQEKEEKVNVLVLTTGMMTYKGRDETNEGLDKKLSLHYYTRMRFIANLLPQLNAAANSPPSTSTGAAEEFNPHGLASVVSVLEAGGEGQLIKDDLSLKSNYSLANARTHAITMTSLSVTELAQSNPSISFTHSFPGVVKTGVIRELGLLGRTIARAGWALARPWMVPIEESGERHLFAAVDQRGEAGQPHLVGSDSEPRGNWNLLEEFKAKKVGEDVWRHTLNVFEEVCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>C8VKI8</accession>
    <name>C8VKI8_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ANIA_11318</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF85761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468759.1">
        <property type="nucleotide sequence ID" value="XM_050612899.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VKI8"/>
    <dbReference type="GeneID" id="74896922"/>
    <dbReference type="KEGG" id="ani:ANIA_11318"/>
    <dbReference type="HOGENOM" id="CLU_2671043_0_0_1"/>
    <dbReference type="InParanoid" id="C8VKI8"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF85761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="75" mass="7992" checksum="B3EC0896A9FE1F10" modified="2009-11-03" version="1">MPPRSLRFRGVSIPINDAPQVYAAAEKKDGGFIRNLKLDEGLGSSDLVAGLKVLSISGGESFKGGLSCWEVELDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>C8VLD7</accession>
    <name>C8VLD7_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ANIA_02009</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="10">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF86004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468790.1">
        <property type="nucleotide sequence ID" value="XM_050612939.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VLD7"/>
    <dbReference type="STRING" id="227321.C8VLD7"/>
    <dbReference type="GeneID" id="2874956"/>
    <dbReference type="KEGG" id="ani:ANIA_02009"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN2009"/>
    <dbReference type="eggNOG" id="KOG0486">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023524_1_0_1"/>
    <dbReference type="InParanoid" id="C8VLD7"/>
    <dbReference type="OMA" id="SHADPMI"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051000">
        <property type="entry name" value="Homeobox_DNA-bind_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057939">
        <property type="entry name" value="TRF2_HOY1_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24324:SF5">
        <property type="entry name" value="HEMATOPOIETICALLY-EXPRESSED HOMEOBOX PROTEIN HHEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24324">
        <property type="entry name" value="HOMEOBOX PROTEIN HHEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24818">
        <property type="entry name" value="PH_TRF2_HOY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="60"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="62"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBF86004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="604" mass="64875" checksum="5CD9EBC2BCD88B3E" modified="2009-11-03" version="1">MSSIDTPAPSTVSTSATAASHPTTSPSSATSTPSPSTSSATTAPSTSARRPQRKSTLTQQQKNNKRQRATQDQLVLLEMEFNKNPTPTAATRERIAQEINMTERSVQIWFQNRRAKIKMLAKKSIETGEGCDSIPESMRQYLAMQFDPSKPGARDPFGRTGGYGANGAYPNEPTPSGKVVIHHFTCRSLTIGSWRRIGQNAMDLVVFYSPEKACMTYYINNDAAGYKIEYPFSYIKNITLESGDQGPQPNGAPPRPTGLVVELNRPPLFYMDSSNSGGFYQCGDFTEDQQASSVMIHRLGGHPKVLSVQLAKLVSLESFQNRLAYGNFPANNSMSPPFIQRPASQPNQFAPAFMSMYAENPAVMNLQAARGHKRQRSRSVPVAIDFSALGAPMTQFSMPQAQQFSQADSGIYAPIPQSTHSLAANLRIDTSSGYAFDPRAHPMSATTTASPSDLASPALFSAGPQGDSTPVGSVGAQFTLPYVSPAVDSGVSTQAASPYSNVSHVDPMIANHSPPLTNMSHTPHDVYGMGSEHQPSYTEEGMPMGGGMYKHINFSSVPTTVGLEGNAFDLPMHSMSGHASPGVQGDYQGIALENVDPNVLTPGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>C8VLW9</accession>
    <name>C8VLW9_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Tyrosine decarboxylase, putative (AFU_orthologue AFUA_2G04980)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ANIA_02091</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5 6">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the group II decarboxylase family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF86161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_659695.2">
        <property type="nucleotide sequence ID" value="XM_654603.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VLW9"/>
    <dbReference type="STRING" id="227321.C8VLW9"/>
    <dbReference type="GeneID" id="2874852"/>
    <dbReference type="KEGG" id="ani:ANIA_02091"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN2091"/>
    <dbReference type="eggNOG" id="KOG0628">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011856_6_2_1"/>
    <dbReference type="InParanoid" id="C8VLW9"/>
    <dbReference type="OMA" id="SWATDAH"/>
    <dbReference type="OrthoDB" id="2161780at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010977">
        <property type="entry name" value="Aromatic_deC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11999:SF165">
        <property type="entry name" value="DECARBOXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G04980)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11999">
        <property type="entry name" value="GROUP II PYRIDOXAL-5-PHOSPHATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 5 6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="5">
        <location>
            <position position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBF86161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="508" mass="55498" checksum="B68E317A9EF419F8" modified="2009-11-03" version="1">MSTMNVDIEATAKEHGQLHQDLWEFLNTEQSTVLPDASSLARARSSLRQSLDDKGIGYDSTRRHILDDLVPAFNLSSISPLYYGFVTGGVTPAALFADGIVSAYDQNVQVHLTEHTIATDVEYATLGLLVDLLRLDHDWHNGTFTTGATASNILGLACGREYVVRQALRKRGPANTQGVGEIGLFEAMHAAGLSGIQVLSTMPHSSLVKAAGVLGIGRANVQNVSDDNHPLRFDLDKVKAKLGDMSKATIIAVSCGEVNTGYFATGGLDEMQKLRKLCDEYGAWLHVDGAFGIFGRVLPETPEFTAIKQGCEGMELADSIAGDGHKMLNVPYDCGFFLTRHRDEAVNVFQNANAAYLTGGTSDAPSIPSPLNIGLENSRRFRALPVYASLLAYGSRGYQTIIEEQIRLARKIAAWLYDHPKYNVLPEVNSKHELLDKTYMVVLFSAKDDNLNCQLAAKIDETRKIYVSGTSWQQRPACRIAISNWRVQADRDFFIVKGVLDEVAGNGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>C8VMN7</accession>
    <name>C8VMN7_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter, putative (AFU_orthologue AFUA_8G05090)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ANIA_01506</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="9">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF85004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468661.1">
        <property type="nucleotide sequence ID" value="XM_050612783.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VMN7"/>
    <dbReference type="GeneID" id="2874982"/>
    <dbReference type="KEGG" id="ani:ANIA_01506"/>
    <dbReference type="eggNOG" id="ENOG502QU6M">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021993_3_1_1"/>
    <dbReference type="InParanoid" id="C8VMN7"/>
    <dbReference type="OMA" id="CACFANI"/>
    <dbReference type="OrthoDB" id="413079at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000555">
        <property type="entry name" value="MFS transporter, putative (AFU_orthologue AFUA_8G05090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051788">
        <property type="entry name" value="MFS_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23514">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23514:SF15">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05090)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="69"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="241"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="271"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="301"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="326"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="359"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="389"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="41"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBF85004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="417" mass="45367" checksum="B489430DD1C5B70C" modified="2009-11-03" version="1">MTLAEHDDLSPHSEGTTTPDENEPNSPVEGTYNDAREVYGKIASTNFSILCGGFNDAALGPLIPYIQPWFHVGLLEISYIYLVSFAGSFSASFANIHICSHLGTGGTLLLGIAIQCTGFTLMFWAPSFPFFLVAFLFTGFGCGLANAQANSFTVTVRNSHRWLGILHAMYGMGTILAPLVANSIAAHLSRWQIYYLISLGLGATNAAFAAWAFRHGLFKPNSEGAKEAAGRELRETLAHRSLWFLTMFFFLYSGAEITLGVGVRHGDPEKVGYVASVFWCGFTFGRVALADVTHRFGERRMVFIYIALALAFQLMFWLIPNILINAISVCLLGFFIGPFYPVGLYVLTQVVPQELHLGAIGFAASFGSVGCAAFPFLTGAIASRAGVEVLQPIMIGLLIGIAFFWAVVPKPKRIRLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>C8VP72</accession>
    <name>C8VP72_EMENI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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    <gene>
        <name evidence="2" type="ORF">ANIA_10312</name>
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    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF86888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050468895.1">
        <property type="nucleotide sequence ID" value="XM_050613053.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VP72"/>
    <dbReference type="STRING" id="227321.C8VP72"/>
    <dbReference type="GeneID" id="74896332"/>
    <dbReference type="KEGG" id="ani:ANIA_10312"/>
    <dbReference type="HOGENOM" id="CLU_2413252_0_0_1"/>
    <dbReference type="InParanoid" id="C8VP72"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF86888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="92" mass="10306" checksum="E0E272DF5733DF83" modified="2009-11-03" version="1">MLALNFDVLIPQWFPVSENTSIVTCLALTYMLDMVMEYLSASGVKSSPPNVNERSFSSSPKFHHKASDIDSLEILVSGRSVDHTESQLCRRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>C8VQD5</accession>
    <name>C8VQD5_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ANIA_11283</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF88683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050469121.1">
        <property type="nucleotide sequence ID" value="XM_050613293.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VQD5"/>
    <dbReference type="GeneID" id="74896892"/>
    <dbReference type="KEGG" id="ani:ANIA_11283"/>
    <dbReference type="HOGENOM" id="CLU_2812333_0_0_1"/>
    <dbReference type="InParanoid" id="C8VQD5"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF88683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="67" mass="7467" checksum="0B6EEB90CAE1CD2D" modified="2009-11-03" version="1">MCVPLASFLHGVFELSSFRITVGDDWEGALFVDSMEKKLLKKYISISKLGGLQKDFTVEDPFPAALE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>C8VRD6</accession>
    <name>C8VRD6_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Histidine--tRNA ligase, mitochondrial</fullName>
            <ecNumber evidence="3">6.1.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Histidyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">ANIA_00046</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="17">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the aminoacylation of histidyl-tRNA in both the cytoplasm and the mitochondrion.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(His) + L-histidine + ATP = L-histidyl-tRNA(His) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17313"/>
            <dbReference type="Rhea" id="RHEA-COMP:9665"/>
            <dbReference type="Rhea" id="RHEA-COMP:9689"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78527"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.21"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.21" evidence="3"/>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF90310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050469352.1">
        <property type="nucleotide sequence ID" value="XM_050611088.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VRD6"/>
    <dbReference type="FunCoup" id="C8VRD6">
        <property type="interactions" value="851"/>
    </dbReference>
    <dbReference type="STRING" id="227321.C8VRD6"/>
    <dbReference type="GeneID" id="2875824"/>
    <dbReference type="KEGG" id="ani:ANIA_00046"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN0046"/>
    <dbReference type="eggNOG" id="KOG1936">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025113_4_2_1"/>
    <dbReference type="InParanoid" id="C8VRD6"/>
    <dbReference type="OMA" id="CGGGNFK"/>
    <dbReference type="OrthoDB" id="1906957at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004821">
        <property type="term" value="F:histidine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990825">
        <property type="term" value="F:sequence-specific mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006427">
        <property type="term" value="P:histidyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00773">
        <property type="entry name" value="HisRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00859">
        <property type="entry name" value="HisRS_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000015">
        <property type="entry name" value="Histidyl-tRNA synthetase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000021">
        <property type="entry name" value="Probable histidine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00127">
        <property type="entry name" value="His_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015807">
        <property type="entry name" value="His-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041715">
        <property type="entry name" value="HisRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004516">
        <property type="entry name" value="HisRS/HisZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033656">
        <property type="entry name" value="HisRS_anticodon"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00442">
        <property type="entry name" value="hisS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11476:SF7">
        <property type="entry name" value="HISTIDINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11476">
        <property type="entry name" value="HISTIDYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13393">
        <property type="entry name" value="tRNA-synt_His"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001549">
        <property type="entry name" value="His-tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="15">
        <location>
            <begin position="49"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="141"/>
            <end position="143"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="338"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="342"/>
            <end position="343"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00058343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00067413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001549-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CBF90310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="549" mass="61481" checksum="41EC0006F5A4A8EA" modified="2009-11-03" version="1">MRLISSVKSFRDLTLCALRRPLIRTLREIRAINVPYQQHFRSLTSQIQEPIDMATKEGKSNKLSFQLKTPKGTRDWIGVDMIIRESIFSAITEVFKRHGGTQLDTPVFELKEILAGKYGEDSRLIYDLADQGGEDSALRYDLTVPLARWLAMNTSVQHIKRFQIAKVYRRDQPAVAKGRMREFYQCDFDIAGSYDPMIPDAEVLRIVVEVFEALNMRDYITIKLNHRKILDGLFGACGVPGDKIRSISSAVDKLDKLPWEQVKLEMEEKGLAPEVADKVGQYVKLSGGRDILDTIRSDDLLSTNENVMKGVEDMELLFKYLEAFDVLDKISFDLSLARGLDYYTGLIYEVVTPLSSAEGFAQSQKKSKSKSNGEDQNIGVGSIAAGGRYDDLVNMFAKKRQIPCVGISFGVDRIFTIMKQRLENEAKEGNASMRASEVDVFVMAFGGKGFNGLLLERMSVANQLWKAGIKAEFAQTVKPKLPQQFKLAEAGGIPLAVILGEDELAAGKVKLKELGLPEGHPEKDGTLISREDLVEEIKKKLNKISLPIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>C8VRP1</accession>
    <name>C8VRP1_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">D-isomer specific 2-hydroxyacid dehydrogenase family protein (AFU_orthologue AFUA_1G13630)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ANIA_00701</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF88958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050469161.1">
        <property type="nucleotide sequence ID" value="XM_050613335.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VRP1"/>
    <dbReference type="STRING" id="227321.C8VRP1"/>
    <dbReference type="GeneID" id="2876482"/>
    <dbReference type="KEGG" id="ani:ANIA_00701"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN0701"/>
    <dbReference type="eggNOG" id="KOG0069">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019796_1_3_1"/>
    <dbReference type="InParanoid" id="C8VRP1"/>
    <dbReference type="OMA" id="LANYSQM"/>
    <dbReference type="OrthoDB" id="298012at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05198">
        <property type="entry name" value="formate_dh_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050418">
        <property type="entry name" value="D-iso_2-hydroxyacid_DH_PdxB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43761:SF1">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE CATALYTIC DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43761">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_1G13630)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="5">
        <location>
            <begin position="36"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="6">
        <location>
            <begin position="117"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBF88958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="334" mass="36146" checksum="6FEA44BC3B3D80B6" modified="2009-11-03" version="1">MPLPSAEHHHIVFLQGSVLEIPKFELPAPFTYSQTVYDWTSSAEVPDRIRDASIIILSAARVDAAALSRDVSPHLKLIVMVASGFDCIDLEACSKRGIVVCNCPNSNIEAVSEHAIGMYFAARRRLLDMHMSTRAGKWKERGLLMFDYLDKDGIPPLTCQDEVAGIIGNGGVGKRIATLARNLGMKVLVSGRKASATSDPTRVPFETVIKQSTVLFIAVPLMNSTRNFISTPEFENMSSHAIVVNVSRGGTVDEEALVHALRERKISGAATDVFNGEPAGPDTSPLLSEDAKDLNIIATPHLAWLSQRTSVNYGSKLKLAVEAWAAGQPVNVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>C8VRU2</accession>
    <name>C8VRU2_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF431 domain protein (AFU_orthologue AFUA_1G08950)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ANIA_10189</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF87604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_658988.2">
        <property type="nucleotide sequence ID" value="XM_653896.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VRU2"/>
    <dbReference type="FunCoup" id="C8VRU2">
        <property type="interactions" value="24"/>
    </dbReference>
    <dbReference type="STRING" id="227321.C8VRU2"/>
    <dbReference type="GeneID" id="2877162"/>
    <dbReference type="KEGG" id="ani:ANIA_10189"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN10189"/>
    <dbReference type="eggNOG" id="ENOG502RZ65">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080487_0_0_1"/>
    <dbReference type="InParanoid" id="C8VRU2"/>
    <dbReference type="OMA" id="LEYIHIC"/>
    <dbReference type="OrthoDB" id="373498at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035241">
        <property type="term" value="F:protein-arginine omega-N monomethyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd18090">
        <property type="entry name" value="Arginine_MT_Sfm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007364">
        <property type="entry name" value="SFM1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35517">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE SFM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35517:SF1">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE SFM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04252">
        <property type="entry name" value="SFM1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF87604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="202" mass="22717" checksum="9D8C4C7A7F2AC9C0" modified="2009-11-03" version="1">MSGRTPVTIVVEHLDPELGTWSALEYGCIARESHAAGSRFLLSSVPKSLQMPDDLAATKGLEVEHRSVEEVFSDRQSKICLLDPSAKVELSPADGDTFEVFLFGGILDRTSELRKKGYEGRRLGPVQMTTDTAVRVTRMVVHDRVPLEEIQYIDNPEIVINEHERTEMPFRYVKDSKGKPIMPEGMVELIKKDAEKSIEDLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>C8VS84</accession>
    <name>C8VS84_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nucleoside phosphorylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ANIA_10180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF87762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050469003.1">
        <property type="nucleotide sequence ID" value="XM_050613167.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VS84"/>
    <dbReference type="STRING" id="227321.C8VS84"/>
    <dbReference type="GeneID" id="74896254"/>
    <dbReference type="KEGG" id="ani:ANIA_10180"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN10180"/>
    <dbReference type="HOGENOM" id="CLU_611150_0_0_1"/>
    <dbReference type="InParanoid" id="C8VS84"/>
    <dbReference type="OrthoDB" id="1577640at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF11">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF87762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="448" mass="49960" checksum="C871D25F58273FD6" modified="2009-11-03" version="1">MIDVLLQVQSLVSPFATFASFHLLSARETDTITSTIDTAKEMLRSAKQALPVKQRLFLHLFSKTAVGTAFLTHAWCGDNTSGHSRNGEHPVHMLWGPNSKLAAQSLTRQFATGYHRRVNARLVEDLVASLVDVFVCCHNSYRHRSHGNTCNVHHISHSCILHSTRVFLMASDKQTDPARVDREQPMVPGRGRVMPALSRHNTWNTSGTTFRCGLTGTFSAGQTLSRRGYTVGLICALHIELAAVRDMLDEIHADLPAPRSDTNTYILGRMCSRNVVITCLPNGIMALSRPRQLLLKCFRPFSLFVSDSYIRRGEDDQLFQADHKHSSPKGSCSNCNKCFVIPRPQRGTESPQIHYVPIASVARFVKDAELRDRLASKLVNLCFEMEAAGLVDNFPCLIIRGISDYADSHKNNHWHGYTAATAAAYAKELLSVITQEEVENECVISQLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C8VTA5</accession>
    <name>C8VTA5_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CHORD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ANIA_10148</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="7">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF88062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050469043.1">
        <property type="nucleotide sequence ID" value="XM_050613210.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VTA5"/>
    <dbReference type="STRING" id="227321.C8VTA5"/>
    <dbReference type="GeneID" id="74896234"/>
    <dbReference type="KEGG" id="ani:ANIA_10148"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN10148"/>
    <dbReference type="eggNOG" id="KOG1667">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040079_2_0_1"/>
    <dbReference type="InParanoid" id="C8VTA5"/>
    <dbReference type="OMA" id="KGYTCCK"/>
    <dbReference type="OrthoDB" id="1898560at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000905">
        <property type="term" value="P:sporocarp development involved in asexual reproduction"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1130.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007051">
        <property type="entry name" value="CHORD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039790">
        <property type="entry name" value="CHRD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46983:SF3">
        <property type="entry name" value="CHPADIPLOID STATE MAINTENANCE PROTEIN CHPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46983">
        <property type="entry name" value="CYSTEINE AND HISTIDINE-RICH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04968">
        <property type="entry name" value="CHORD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51401">
        <property type="entry name" value="CHORD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CHORD" evidence="5">
        <location>
            <begin position="5"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="CHORD" evidence="5">
        <location>
            <begin position="134"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="58"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="104"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBF88062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="209" mass="22901" checksum="2E43423676D0B02C" modified="2009-11-03" version="1">MATKCVHKGCGKVFTDPEEPCVYHPGPPVFHEGQKGWNCCKPRVLTFEEFMEIPPCTTGKHSAVDDTPAPAQKKDTPAESQPPVAAPVPVRDSGVPRPVAHSPAIPPPSNAPTPVPEEPESDDPELAIPENATCRRRGCGGTYKPDVSRDEERCVYHPGQPVFHEGSKGWSCCKRRVLEFDEFLKIEGLRGEEEASFCREGQACWRGEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>C8VTM0</accession>
    <name>C8VTM0_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">guanosine-diphosphatase</fullName>
            <ecNumber evidence="5">3.6.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ANIA_01082</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">After transfer of sugars to endogenous macromolecular acceptors, the enzyme converts nucleoside diphosphates to nucleoside monophosphates which in turn exit the Golgi lumen in a coupled antiporter reaction, allowing entry of additional nucleotide sugar from the cytosol.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the GDA1/CD39 NTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.42" evidence="5"/>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF88182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050469060.1">
        <property type="nucleotide sequence ID" value="XM_050613229.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C8VTM0"/>
    <dbReference type="FunCoup" id="C8VTM0">
        <property type="interactions" value="363"/>
    </dbReference>
    <dbReference type="STRING" id="227321.C8VTM0"/>
    <dbReference type="GeneID" id="2876858"/>
    <dbReference type="KEGG" id="ani:ANIA_01082"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN1082"/>
    <dbReference type="eggNOG" id="KOG1385">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010246_4_0_1"/>
    <dbReference type="InParanoid" id="C8VTM0"/>
    <dbReference type="OMA" id="WTCRIKE"/>
    <dbReference type="OrthoDB" id="6372431at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004382">
        <property type="term" value="F:GDP phosphatase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017111">
        <property type="term" value="F:ribonucleoside triphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045134">
        <property type="term" value="F:UDP phosphatase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009134">
        <property type="term" value="P:nucleoside diphosphate catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd24040">
        <property type="entry name" value="ASKHA_NBD_GDA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.150">
        <property type="entry name" value="Exopolyphosphatase. Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000407">
        <property type="entry name" value="GDA1_CD39_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11782">
        <property type="entry name" value="ADENOSINE/GUANOSINE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11782:SF83">
        <property type="entry name" value="GUANOSINE-DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01150">
        <property type="entry name" value="GDA1_CD39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01238">
        <property type="entry name" value="GDA1_CD39_NTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="25"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="25"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="160"/>
            <end position="164"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR600407-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600407-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBF88182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="444" mass="48621" checksum="219436000BF3F631" modified="2009-11-03" version="1">MMIDAGSQGSRIHVYRFNNCGPTPELEHEEFKQTEPKEGGSGLSSYKEDAEGAAKSLDPLMAVAMSTVPDEYKSCSPIAVKATAGLRMLGSELSEKILEAVRTRLETVYPFPVVSREKGGVEIMDGKDEGVYAWITTNYLLGKIGGPDETPTAAVFDLGGGSTQIVFQPTFEKSPSGGMPEHLAEGDHKYDLQFGGRHFELYQHSHLGYGLMAARDAVHKAIVEAKLASMPPDDRSWLKQPISNPCIGPGMEREVKLKYEGEQANHPLAPGVTVKMVGPKEGAPSTAAQCRGLTEKILNKDAACTLAPCSFNGVHQPSLEKTFAKEDVYIFSYFYERTQPLGMPDSFTLDELHDLTKTVCAGESAWSVFEGIPDALKELRDRPEWCLDLNFQLGLLHTGYEMPLSREVKIAKKIKGNELGWCLGASLPLLSQESGWTCRVKEIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-11-03" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>C8VTU6</accession>
    <name>C8VTU6_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">[histone H3]-trimethyl-L-lysine(9) demethylase</fullName>
            <ecNumber evidence="2">1.14.11.66</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ANIA_01060</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + 2 2-oxoglutarate + 2 O2 = N(6)-methyl-L-lysyl(9)-[histone H3] + 2 formaldehyde + 2 succinate + 2 CO2</text>
            <dbReference type="Rhea" id="RHEA:60200"/>
            <dbReference type="Rhea" id="RHEA-COMP:15538"/>
            <dbReference type="Rhea" id="RHEA-COMP:15542"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:16842"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:61929"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="1.14.11.66"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the JHDM3 histone demethylase family.</text>
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    <dbReference type="EC" id="1.14.11.66" evidence="2"/>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF88234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="XP_050469070.1">
        <property type="nucleotide sequence ID" value="XM_050613240.1"/>
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    <dbReference type="STRING" id="227321.C8VTU6"/>
    <dbReference type="GeneID" id="2876835"/>
    <dbReference type="KEGG" id="ani:ANIA_01060"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN1060"/>
    <dbReference type="eggNOG" id="KOG0954">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="eggNOG" id="KOG0958">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001442_1_3_1"/>
    <dbReference type="InParanoid" id="C8VTU6"/>
    <dbReference type="OMA" id="EQMWYYL"/>
    <dbReference type="OrthoDB" id="9547406at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
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    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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    <dbReference type="GO" id="GO:0051864">
        <property type="term" value="F:histone H3K36 demethylase activity"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="AspGD"/>
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    <dbReference type="GO" id="GO:0032454">
        <property type="term" value="F:histone H3K9 demethylase activity"/>
        <property type="evidence" value="ECO:0000318"/>
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    <dbReference type="GO" id="GO:0140684">
        <property type="term" value="F:histone H3K9me2/H3K9me3 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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    <dbReference type="GO" id="GO:0040029">
        <property type="term" value="P:epigenetic regulation of gene expression"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="AspGD"/>
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        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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    <dbReference type="CDD" id="cd15571">
        <property type="entry name" value="ePHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.650:FF:000024">
        <property type="entry name" value="Putative jumonji family transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.650:FF:000047">
        <property type="entry name" value="Putative jumonji family transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="2"/>
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    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055500">
        <property type="entry name" value="DUF7072"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034732">
        <property type="entry name" value="EPHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003349">
        <property type="entry name" value="JmjN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10694:SF7">
        <property type="entry name" value="[HISTONE H3]-TRIMETHYL-L-LYSINE(9) DEMETHYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10694">
        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23258">
        <property type="entry name" value="DUF7072"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF02373">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02375">
        <property type="entry name" value="JmjN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13832">
        <property type="entry name" value="zf-HC5HC2H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00545">
        <property type="entry name" value="JmjN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51805">
        <property type="entry name" value="EPHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51183">
        <property type="entry name" value="JMJN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="JmjN" evidence="8">
        <location>
            <begin position="76"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="JmjC" evidence="9">
        <location>
            <begin position="347"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="10">
        <location>
            <begin position="590"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="165"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="549"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1001"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="56"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="218"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="273"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1007"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1020"/>
            <end position="1032"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CBF88234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="1405" mass="156910" checksum="DA6F03372E65DA97" modified="2009-11-03" version="1">MAATIDRPLFEPIAGGPATDAASITPPHSINGKKDGPDGAPSELSDLELDSKPTDAQEDISVEEGDQEIEPDHYYGGGKIPVFKPFRDFQSFIKRIDKYGMRSGVVKVIPPKEWRDALPPLDEAVKKIRVKNPIMQEFHGSHGTYTQANIEKQRSYNLPQWKALCEDGSHQPPARRGERRRNQERVTRAPSAPKAQTTRADTPKRGPGRPAKRSNQAKVKEEPVKIKEEPAADEVMEKIKPEGPPTPVSPESIPAETKSEALSDGESLSAPKSRGRQPKSVTARRKQNKGDTVEHVDEEAYKNFDYRIHDNEDYTPERCEELETAYWKSLMFNNPMYGADMPGSLFDDRITSWNVAKLPNLLDVIGQKVPGVNTAYLYLGMWKATFAWHLEDVDLYSINYIHFGAPKQWYSISQEDAPRFEQAMKSIWPSDAKTCDQFLRHKTYLVSPSLLKSQYGITVNKMVHYEGEFVITYPYGYHSGYNLGYNCAESVNFATEKWLDYGRVAKKCNCEADSVWIDVEEIERKLRGELTPEYYGEYDSDLDGYEAASDLLTPPRSVPEKTSNRGRKRKHDGDMNKAKRMRADMGIPRRLPCLLCPNDLDYEDLLPTEDGKSHAHRRCALYTEETSILRDGSGKEVVCDIDKIPKARMGLKCLYCREVRGACFQCNFGKCTRSYHATCALLAGVQVEEGLVTVVADDGSQYSVPSVDLKCKYHRQKKPTWMTSSESPENDRKLMDTARRLVTGDILQFQADKEIYGAVVIENRVAERTLQVKVLPRGDVIELPYRWMLVVRRSNFAPLAAGIKPLPAHLSRKPEGRRELESALPVAGNPFGDGRSPYQWAEFETVDSTNRPAAPPAVQVDLGKMEQIWYYLGQSSTECRAQYTHNPSVPIHNPRSNFLDSVKSLGAVMARLPSYPHHRLPSYVLTTPPPHLLSSAAATTTASAVAAAAASRPLLPPRPPFAPPRSSPAAPTSAAVAASAMPSAYRSLPNQIARHAPYPQVTKAHLQSQQQHSHQQQQQNTNGSHSTANSHLPANNFANVRELIARRRLAQITDHANVFAGYTIVGPELVVETLLGPMGSVPPSNGLEKLELAMAQQRVQPRAPDGTLLPMQPLNMRSEEVTRLLQMLRFSLISHRDRLDVLQKKETETAKQEAANKVKGATPKLPRKYAYLELQREQAPTVYQSPYDMPSGFTEYARTTFGLTRHEPELPKPSLANDYFASLSPENQEKILKTCGSFVQRAIERSAPHSRQSSSSNFRLASALAQQTENPTIDITTVENMPLSGLDFPLRADSPCSNFSRSHLRFHSPNDFSHHGTEVHHDHHDLFGDQQANTRFWQHGPWAAGDGNTPNEENRPFFGPHERLKHDYASSDISLGRGGPGSLHSVDMAGFGLDNPDDLCAALSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-12-14" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>G5EB10</accession>
    <accession>C8VR25</accession>
    <name>G5EB10_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Integral membrane protein TmpA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">tmpA</name>
        <name evidence="2" type="ORF">ANIA_00055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF90292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_657659.1">
        <property type="nucleotide sequence ID" value="XM_652567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G5EB10"/>
    <dbReference type="GeneID" id="2875832"/>
    <dbReference type="KEGG" id="ani:ANIA_00055"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN0055"/>
    <dbReference type="eggNOG" id="ENOG502QWJ3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005562_3_0_1"/>
    <dbReference type="InParanoid" id="G5EB10"/>
    <dbReference type="OMA" id="MYRRATM"/>
    <dbReference type="OrthoDB" id="3142841at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048315">
        <property type="term" value="P:conidium formation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0075306">
        <property type="term" value="P:regulation of conidium formation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043935">
        <property type="term" value="P:sexual sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052979">
        <property type="entry name" value="Adenylate-forming_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33927:SF3">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN TMPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33927">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="259"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF90292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="486" mass="54473" checksum="3B7D175C57219A14" modified="2011-12-14" version="1">MSQPEEVIVTRPPTAVCVPESPSETSFVNIEKCIIKDVSELMLPDEPSFDLEAQSTARRLISPIRYTFLNIYRRLFTLVFLANIGVFVYVMVADRKLLALVNAAAANLLACGLARQPLVVNTIFFTVCSIPRSAPLWLRRIASKVYHYGGVHSGCGVASLIWYLGFIGEFSRQYWSGSSSPFSAAPIVLAYIILVLLLAIIIVAYPTFRFKRHDYFELTHRFSGWLIVALFVILLMVFVDEASAAEGKPMGRFLIELPAFWFLMLVVLAIIHPWLLLRKVKVTPEYLSPHAVRLHFSHTTTTFGKGIQLSKHPLQDWHGFATFPDVDRDGKSFSSLVSKAGDWTAATIKDQPTHLWKRGVLIYGFAYAMRVYKRVVVVTTGSGIGPCLSFLGDENRPSLRVIWQTRAPKRTYGKEVLNLVGRMDPNPVIIDTNSSGRLDMVPVIRQIAREHDAEAICVISNPFVTKKVVYELESMGIPAYGPIFDS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2024-10-02" modified="2026-01-28" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>G5EB74</accession>
    <accession>C8V172</accession>
    <name>CHS5_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Chitin synthase csmA</fullName>
            <ecNumber evidence="14">2.4.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Chitin-UDP acetyl-glucosaminyl transferase csmA</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Class-V chitin synthase csmA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">csmA</name>
        <name type="ORF">ANIA_06318</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="1997" name="Biochem. Biophys. Res. Commun." volume="236" first="75" last="78">
            <title>A novel fungal gene encoding chitin synthase with a myosin motor-like domain.</title>
            <authorList>
                <person name="Fujiwara M."/>
                <person name="Horiuchi H."/>
                <person name="Ohta A."/>
                <person name="Takagi M."/>
            </authorList>
            <dbReference type="PubMed" id="9223429"/>
            <dbReference type="DOI" id="10.1006/bbrc.1997.6907"/>
        </citation>
        <scope>DOMAIN</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="1999" name="J. Bacteriol." volume="181" first="3721" last="3729">
            <title>Proliferation of intrahyphal hyphae caused by disruption of csmA, which encodes a class V chitin synthase with a myosin motor-like domain in Aspergillus nidulans.</title>
            <authorList>
                <person name="Horiuchi H."/>
                <person name="Fujiwara M."/>
                <person name="Yamashita S."/>
                <person name="Ohta A."/>
                <person name="Takagi M."/>
            </authorList>
            <dbReference type="PubMed" id="10368147"/>
            <dbReference type="DOI" id="10.1128/jb.181.12.3721-3729.1999"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>DOMAIN</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2002" name="Biochem. Biophys. Res. Commun." volume="298" first="103" last="109">
            <title>csmA, a gene encoding a class V chitin synthase with a myosin motor-like domain of Aspergillus nidulans, is translated as a single polypeptide and regulated in response to osmotic conditions.</title>
            <authorList>
                <person name="Takeshita N."/>
                <person name="Ohta A."/>
                <person name="Horiuchi H."/>
            </authorList>
            <dbReference type="PubMed" id="12379226"/>
            <dbReference type="DOI" id="10.1016/s0006-291x(02)02418-x"/>
        </citation>
        <scope>INDUCTION</scope>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2005" name="Mol. Biol. Cell" volume="16" first="1961" last="1970">
            <title>CsmA, a class V chitin synthase with a myosin motor-like domain, is localized through direct interaction with the actin cytoskeleton in Aspergillus nidulans.</title>
            <authorList>
                <person name="Takeshita N."/>
                <person name="Ohta A."/>
                <person name="Horiuchi H."/>
            </authorList>
            <dbReference type="PubMed" id="15703213"/>
            <dbReference type="DOI" id="10.1091/mbc.e04-09-0761"/>
        </citation>
        <scope>DOMAIN</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH F-ACTIN</scope>
        <scope>MUTAGENESIS OF ARG-347 AND 347-ARG--VAL-356</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2006" name="Mol. Microbiol." volume="59" first="1380" last="1394">
            <title>Aspergillus nidulans class V and VI chitin synthases CsmA and CsmB, each with a myosin motor-like domain, perform compensatory functions that are essential for hyphal tip growth.</title>
            <authorList>
                <person name="Takeshita N."/>
                <person name="Yamashita S."/>
                <person name="Ohta A."/>
                <person name="Horiuchi H."/>
            </authorList>
            <dbReference type="PubMed" id="16468983"/>
            <dbReference type="DOI" id="10.1111/j.1365-2958.2006.05030.x"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="8">
        <citation type="journal article" date="2015" name="PLoS ONE" volume="10" first="e0125937" last="e0125937">
            <title>Transportation of Aspergillus nidulans Class III and V Chitin Synthases to the Hyphal Tips Depends on Conventional Kinesin.</title>
            <authorList>
                <person name="Takeshita N."/>
                <person name="Wernet V."/>
                <person name="Tsuizaki M."/>
                <person name="Gruen N."/>
                <person name="Hoshi H.O."/>
                <person name="Ohta A."/>
                <person name="Fischer R."/>
                <person name="Horiuchi H."/>
            </authorList>
            <dbReference type="PubMed" id="25955346"/>
            <dbReference type="DOI" id="10.1371/journal.pone.0125937"/>
        </citation>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>INTERACTION WITH KINA</scope>
    </reference>
    <comment type="function">
        <text evidence="7 8 9 10 14">Polymerizes chitin, a structural polymer of the cell wall and septum, by transferring the sugar moiety of UDP-GlcNAc to the non-reducing end of the growing chitin polymer (Probable). Plays an important role in polarized hyphal cell wall synthesis and maintenance of cell wall integrity (PubMed:10368147, PubMed:15703213, PubMed:16468983). Its role in growth and morphogenesis is particularly important under low osmotic conditions (PubMed:12379226).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9595"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="EC" id="2.4.1.16"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:16638"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="9 11">Binds F-actin via its N-terminal myosin motor-like domain (MMD) (PubMed:15703213). Interacts with kibesin kinA (PubMed:25955346).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9 11">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9 11">Cell septum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9 11">Cell tip</location>
        </subcellularLocation>
        <text evidence="9">Localization to the hyphal tips depends on conventional kinesin kinA (PubMed:15703213). Concentrates at the hyphal tips and septation sites near actin structures, which is dependent on the actin-binding ability of the N-terminal myosin motor-like domain (MMD) (PubMed:15703213).</text>
    </comment>
    <comment type="induction">
        <text evidence="8">Expression is increased under low osmotic conditions (PubMed:12379226). An abaA response element (ARE) and two CCAAT sequences, to which the HAP complex binds, are found in the promoter region of csmA (PubMed:12379226). Moreover, consensus sequences that are recognized by Rlmp and Msn2/Msn4, transcription factors known to be involved in the response to osmotic stress, are also present in the promoter (PubMed:12379226).</text>
    </comment>
    <comment type="domain">
        <text evidence="7 9 15">The N-terminal myosin motor-like domain (MMD) does not seem to have motor activity but is indispensable for polarized cell wall synthesis via binding to actin that ensures the proper localization to the hyphal tips and septation sites near actin structures.</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="7">Severely inhibits hyphal growth in the presence of chitin-binding reagent, Calcofluor white or Congo red (PubMed:10368147). Leads to morphological abnormalities in tip growth and septum formation (PubMed:10368147). Also results in proliferation of intracellular new hyphae, called intrahyphal hyphae (PubMed:10368147).</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">In the N-terminal section; belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">In the C-terminal section; belongs to the chitin synthase family. Class V subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="14"/>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF69713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_663922.1">
        <property type="nucleotide sequence ID" value="XM_658830.1"/>
    </dbReference>
    <dbReference type="SMR" id="G5EB74"/>
    <dbReference type="STRING" id="227321.G5EB74"/>
    <dbReference type="CAZy" id="GT2">
        <property type="family name" value="Glycosyltransferase Family 2"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CBF69713">
        <property type="protein sequence ID" value="CBF69713"/>
        <property type="gene ID" value="ANIA_06318"/>
    </dbReference>
    <dbReference type="KEGG" id="ani:ANIA_06318"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN6318"/>
    <dbReference type="eggNOG" id="KOG2571">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4229">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000192_0_2_1"/>
    <dbReference type="InParanoid" id="G5EB74"/>
    <dbReference type="OMA" id="LEMHHQI"/>
    <dbReference type="OrthoDB" id="370884at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001411">
        <property type="term" value="C:hyphal tip"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009932">
        <property type="term" value="P:cell tip growth"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071470">
        <property type="term" value="P:cellular response to osmotic stress"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048315">
        <property type="term" value="P:conidium formation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030448">
        <property type="term" value="P:hyphal growth"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <dbReference type="CDD" id="cd14879">
        <property type="entry name" value="MYSc_Myo17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000337">
        <property type="entry name" value="Chitin synthase 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.820:FF:000012">
        <property type="entry name" value="Chitin synthase ChsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.530:FF:000017">
        <property type="entry name" value="Chitin synthase ChsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000019">
        <property type="entry name" value="Chitin synthase ChsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000055">
        <property type="entry name" value="Chitin synthase ChsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014876">
        <property type="entry name" value="DEK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036037">
        <property type="entry name" value="MYSc_Myo17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF45">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03142">
        <property type="entry name" value="Chitin_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08766">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109715">
        <property type="entry name" value="DEK C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51998">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0009">Actin-binding</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0328">Glycosyltransferase</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0505">Motor protein</keyword>
    <keyword id="KW-0518">Myosin</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000460854" description="Chitin synthase csmA">
        <location>
            <begin position="1"/>
            <end position="1852"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="895"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="930"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1205"/>
            <end position="1225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1600"/>
            <end position="1620"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1626"/>
            <end position="1646"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1653"/>
            <end position="1673"/>
        </location>
    </feature>
    <feature type="domain" description="Myosin motor" evidence="4">
        <location>
            <begin position="1"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="2">
        <location>
            <begin position="958"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="domain" description="DEK-C" evidence="5">
        <location>
            <begin position="1794"/>
            <end position="1849"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="599"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="4">
        <location>
            <begin position="667"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="102"/>
            <end position="109"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="642"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="840"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="1044"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="1195"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="1428"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="1462"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="1568"/>
        </location>
    </feature>
    <feature type="mutagenesis site" description="Abolished interactions between the MMD and F-actin and impairs localization at hyphal tips and septation sites." evidence="9">
        <original>RTKTIHRERV</original>
        <variation>AAAAAAAAAA</variation>
        <location>
            <begin position="347"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="mutagenesis site" description="Lowers interactions between the MMD and F-actin." evidence="9">
        <original>R</original>
        <variation>A</variation>
        <location>
            <position position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="7">
        <source>
            <dbReference type="PubMed" id="10368147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="8">
        <source>
            <dbReference type="PubMed" id="12379226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="9">
        <source>
            <dbReference type="PubMed" id="15703213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="10">
        <source>
            <dbReference type="PubMed" id="16468983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="11">
        <source>
            <dbReference type="PubMed" id="25955346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="12">
        <source>
            <dbReference type="PubMed" id="9223429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="13"/>
    <evidence type="ECO:0000305" key="14">
        <source>
            <dbReference type="PubMed" id="10368147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="15">
        <source>
            <dbReference type="PubMed" id="9223429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CBF69713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="1852" mass="206027" checksum="DBD2D57A0D42617F" modified="2011-12-14" version="1">MVGTLPAGHTPSHVQSSLPSLPAHLQSDTHLTAHLASRFHVGLPTARLSSHALISLNNYTSSSKGPDGGKEGSAMGETEDLARRAYTRLGARGENQAIVFLGESGAGKTTLRSHLLSSFLSFSSTPLSSKLSYAAFIFDTLTTTKSLTTPTASKAGLFLELQYDASSSVNPTLIGGKIIDHRLERSRIASVPTGERSFHVLYYLLAGTSAAEKAHLGLDSPIHVTTAGGRLSSADHKRWRYLGHPTQLKVGINDADGFQHFKTALRKLEFPRSEIAEICQILAAILHIGQLDFGSGQATLTGAEESGGYSHEGGETVTVVKNKDVLSIIAAFLGLGVGELEASFGYRTKTIHRERVTVMLDPKGARRSADELSRVLYSLLVAYVIENVNQRICAAEDSVANTVSIIDFPGFAQACSTGSTLDQLLNNAACESLYNFCLRSFFDRKADMLEREEVAVPATSYFDNTDAVRGLLKQGNGLLSILDDQTRRGRTDAQFVEAVRRRFENKNPAITAGASGSGNGYGMVSQNARSSFTVKHFAGEVDYSATGLLEENGEVISGDLMNLMKSTRSDFVRELFGQEALQTVAHPKEKTAIMQAQVSSKPLRMPSMARRKTSPASRLTFDATPAEDPYETESQTGSSAKNSSAKRKSGMLMGGMQCAAGQFLSSLDIVNKCLTSGNLNPYFVFCLKPNDRRIANQFDSKCVRTQIQTLGIAEISQRLRNADFSVFLPFAEFLGLAEVGNVVVGSDKEKSEVVLDEKRWPGNEARVGSTGVFLSERCWADLAKVGERVIPSFAAEDDGGDALLHPRTANYADSKVRLLNPSDHSPGAYIYGDESKQASNTSRDFDGRSDAGYSAFNSGDMFHNLETREQMLEKGNEKQMEEVDEVPVSGSRKRWMAIVWLLTFYIPTPAIRYIGRMKRKDIQIAWREKFAINLLIWLACAIAVFIIVGFPSLICPTQHVYSPAELSSHDGKDGHSSYTSIRGLVLDLGEFMDSHYPGIVPDSALKKYAGVDSTALFPVQVSALCLGKDGNVDPKVLLDYKPTNFSGSVTSTSSGDPNSVYHDFRYFRDDYRPDWYAEQMIYLRANYYKGWIGYSSEYLHTLASKSQNVASINGKIYDLTSYIAGGRRIQGREGDDTTGIDTDFMDSLVVDLFQQKAGEDITKYWEDLPLTPKLRVDMMDCLNNLFIVGHVDTRNSTQCQFARYFILAISVLICSVIVFKFFAALQFGKKNVPENLDKFIICQVPAYTEDEESLRRAIDSMARMQYDDKRKLLVVICDGMIIGQGNDRPTPRIVLDILGVPESVDPEPLSFESLGEGMKQHNMGKVYSGLYEVQGHIVPFLVVVKVGKPSEVSRPGNRGKRDSQMVLMRFLNRVHYNLPMSPMELEMHHHIRNIIGVNPTFYEFILQVDADTVVAPDAATRMVSSCLNDTRIIGVCGETSLTNAKTSAVTMIQVYEYYISHNLTKAFESLFGSITCLPGCFTMYRIRSAESGKPLFVSKEIVEAYSEIRVDTLHMKNLLHLGEDRYLTTLLLKHHPKFKTKYNFRAQAYTIAPESWTVFLSQRRRWINSTVHNLVELIPLQQLCGFCCFSMRFVVFIDLISTIIMPVTVAYIVYLIVWLVRDTSTIPWTSFLLLAAIYGLQAIIFIVRRKWEMIGWMIIYILAIPVYSLALPLYSFWHMDDFSWGNTRIITGEKGRKIVISDEGKFDPASIPKKRWEEYQAELWEAQTSRDDRSEISGISYGTKYHPATQSEYGFPGSRPMSQLELPRHMSRMSLAPSEMMSRHMDMELEDVNLPSDDAILSEIRDILRTADLMTVTKKNIKQELERRFGVNLDAKRPYINSATEAVLSGNL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2002-11-15" modified="2025-02-05" version="104" xmlns="https://uniprot.org/uniprot">
    <accession>O60039</accession>
    <accession>C8VHD3</accession>
    <accession>Q5B7P3</accession>
    <name>APSB_EMENI</name>
    <protein>
        <recommendedName>
            <fullName>Anucleate primary sterigmata protein B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">apsB</name>
        <name type="ORF">AN3437</name>
    </gene>
    <organism>
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Mol. Microbiol." volume="30" first="831" last="842">
            <title>Increased nuclear traffic chaos in hyphae of Aspergillus nidulans: molecular characterization of apsB and in vivo observation of nuclear behaviour.</title>
            <authorList>
                <person name="Suelmann R."/>
                <person name="Sievers N."/>
                <person name="Galetzka D."/>
                <person name="Robertson L."/>
                <person name="Timberlake W.E."/>
                <person name="Fischer R."/>
            </authorList>
            <dbReference type="PubMed" id="10094631"/>
            <dbReference type="DOI" id="10.1046/j.1365-2958.1998.01115.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in regulation of nuclear migration. May be involved in regulating nuclear positioning.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AJ003163">
        <property type="protein sequence ID" value="CAA05918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AACD01000057">
        <property type="protein sequence ID" value="EAA62893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF82712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T18302">
        <property type="entry name" value="T18302"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_661041.1">
        <property type="nucleotide sequence ID" value="XM_655949.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O60039"/>
    <dbReference type="SMR" id="O60039"/>
    <dbReference type="STRING" id="227321.O60039"/>
    <dbReference type="EnsemblFungi" id="CBF82712">
        <property type="protein sequence ID" value="CBF82712"/>
        <property type="gene ID" value="ANIA_03437"/>
    </dbReference>
    <dbReference type="GeneID" id="2874340"/>
    <dbReference type="KEGG" id="ani:ANIA_03437"/>
    <dbReference type="eggNOG" id="ENOG502QU0H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000791_0_0_1"/>
    <dbReference type="InParanoid" id="O60039"/>
    <dbReference type="OMA" id="GNILFWP"/>
    <dbReference type="OrthoDB" id="10255000at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012943">
        <property type="entry name" value="Cnn_1N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024545">
        <property type="entry name" value="Mto1-like_Mto2p-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07989">
        <property type="entry name" value="Cnn_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12808">
        <property type="entry name" value="Mto2_bdg"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000064646" description="Anucleate primary sterigmata protein B">
        <location>
            <begin position="1"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="58"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="294"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="877"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="909"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="984"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="10"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="239"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="325"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="787"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="950"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="58"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="294"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="309"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="877"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="916"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="984"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1028"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; CAA05918." evidence="4" ref="1">
        <original>M</original>
        <variation>I</variation>
        <location>
            <position position="840"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="10094631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="1051" mass="121015" checksum="C0CC41EA8C326DBD" modified="2007-05-01" version="2">MTLKEQSSTIDRLSKENFDLKMRIHFLNEALNRRSEEGIKEMISENVELKSDKLKLQKDNQGLKRKIRDLEKQLKDQQSDKESMLNHDPEGGSDEEDRDHAQDEELLFLRERVETYELEIERLRSESIARESEKRRLAEMLKSLNDGRPTGSDSGAREERDMWKDMLDAETAAREQADEENKRLREELMRVRSEATYAIAPAAPLRSGHRNRGDSLVSHSAVSDRELYRNTAAGSSSSSTLVMEFELLKQENAELRREVSAQTSMLTSRNREKERLYQEIEELKLGQRRDRSIAGDSILDRSASRAQGRPSSSISDRTGQSPIDDAEREDWELRNGQLRDQVSALKLENQAIRQELEELDKAYSADVEQAEEDIQTLQQERDQAMQVAEERDAAFQELRAEAQEELDALGDELDQKIEECQRLTEDLRTQDDNLRALQAEMRSASEGIIRLEEDAQNNLQRYKAVQQELEQCNEEMESLEKSLYEANSKVQRLTVQIESSQNEIAFLREEQDGDKIKIGDLESELKTYRMSLQSEKDKTKELEGRLAEERYQREVVGSKEKQEVQRIMNELNREVSAAKEECRKLKKNLSAQEIETNTWKERLTDLENNLRETLGDLTGSRSSLIANIMKLQKELESTALELESTRSTLDEKETLLRNRDALLESHGLESRKLSELLERERQARRADKQSFEQALKSHHQASRTITQNNSRILELENARNQDRKRFTSLEQQFREQLNERNSMLLTIWKRLSGMCGPDWAHSNSLINGNLPSQEVIGNILFWPGFSRNLLLAVKTLENVISSFKTRVKDVERNLTKQYQTLEHAFSLRIKKLDRLEETTMNMRAQLQTRNQTGLSPELSKLRGENRLLKAELNLLQNHPRSRSTTAGVAGSPQSSTIDLAERGSLVRANTAAESPARSSIPQPAQMTNLAEPTGAVTRPRQFKPSDNHGNQEVWIKRLHELERRLKAEREARLLDRNGARRRLEERDAENKRLRAQLDRQRLRQGVSTETSTDDGGHGPPSEPTTGDEGYREREEEHSSSEGEGITVDIEV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-07-19" modified="2026-01-28" version="155" xmlns="https://uniprot.org/uniprot">
    <accession>O93937</accession>
    <accession>C8VSK1</accession>
    <accession>Q5BFW5</accession>
    <name>PYR1_EMENI</name>
    <protein>
        <recommendedName>
            <fullName>Multifunctional protein pyrABCN</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Pyrimidine-specific carbamoyl phosphate synthase-aspartate carbamoyl transferase</fullName>
            <shortName>CPSase-ATCase</shortName>
        </alternativeName>
        <domain>
            <recommendedName>
                <fullName>Glutamine-dependent carbamoyl phosphate synthase</fullName>
                <ecNumber>6.3.5.5</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName>Carbamoyl phosphate synthase P</fullName>
                <shortName>CPS-P</shortName>
                <shortName>CPS-pyr</shortName>
                <shortName>CPSase P</shortName>
            </alternativeName>
            <alternativeName>
                <fullName>Pyrimidine-specific carbamoyl phosphate synthase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName>Glutamine amidotransferase</fullName>
                <shortName>GATase</shortName>
                <shortName>GLNase</shortName>
                <ecNumber>3.5.1.2</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName>Ammonium-dependent carbamoyl phosphate synthase</fullName>
                <shortName>CPS</shortName>
                <shortName>CPSase</shortName>
                <ecNumber>6.3.4.16</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName>Aspartate carbamoyltransferase</fullName>
                <shortName>ATCase</shortName>
                <ecNumber>2.1.3.2</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName>Aspartate transcarbamylase</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="12" type="primary">pyrABCN</name>
        <name type="ORF">AN0565</name>
    </gene>
    <organism>
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="1999" name="Mol. Microbiol." volume="33" first="599" last="611">
            <title>Structural and transcriptional analysis of the pyrABCN, pyrD and pyrF genes in Aspergillus nidulans and the evolutionary origin of fungal dihydroorotases.</title>
            <authorList>
                <person name="Aleksenko A."/>
                <person name="Liu W."/>
                <person name="Gojkovic Z."/>
                <person name="Nielsen J."/>
                <person name="Piskur J."/>
            </authorList>
            <dbReference type="PubMed" id="10417650"/>
            <dbReference type="DOI" id="10.1046/j.1365-2958.1999.01507.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Multifunctional protein that encodes the first 2 enzymatic activities of the de novo pyrimidine pathway: carbamoylphosphate synthetase (CPSase; EC 6.3.5.5) and aspartate transcarbamylase (ATCase; EC 2.1.3.2). The CPSase-function is accomplished in 2 steps, by a glutamine-dependent amidotransferase activity (GATase) that binds and cleaves glutamine to produce ammonia, followed by an ammonium-dependent carbamoyl phosphate synthetase, which reacts with the ammonia, hydrogencarbonate and ATP to form carbamoyl phosphate. The endogenously produced carbamoyl phosphate is sequestered and channeled to the ATCase active site. ATCase then catalyzes the formation of carbamoyl-L-aspartate from L-aspartate and carbamoyl phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>hydrogencarbonate + L-glutamine + 2 ATP + H2O = carbamoyl phosphate + L-glutamate + 2 ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:18633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-glutamine + H2O = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>hydrogencarbonate + NH4(+) + 2 ATP = carbamoyl phosphate + 2 ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:18029"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>carbamoyl phosphate + L-aspartate = N-carbamoyl-L-aspartate + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20013"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:32814"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="EC" id="2.1.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="6">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="6">Binds 4 Mg(2+) or Mn(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 1/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3.</text>
    </comment>
    <comment type="domain">
        <text evidence="11">The DHOase domain is defective. The third step of the de novo pyrimidine pathway, dihydroorotase (DHOase) is encoded by the pyrD gene which is both physically and genetically independent of the pyrABCN gene.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="10">In eukaryotes, carbamoyl phosphate synthase is synthesized by 2 pathway-specific (arginine and pyrimidine) genes under separate control.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="2">GATase (glutamine amidotransferase) and CPSase (carbamoyl phosphate synthase) form together the glutamine-dependent CPSase (CPSase P) (EC 6.3.5.5).</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">In the central section; belongs to the metallo-dependent hydrolases superfamily. DHOase family. CAD subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">In the N-terminal section; belongs to the CarA family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">In the 2nd section; belongs to the CarB family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">In the 3rd section; belongs to the metallo-dependent hydrolases superfamily. DHOase family. CAD subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">In the C-terminal section; belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.</text>
    </comment>
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        <property type="protein sequence ID" value="EAA66664.1"/>
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    </dbReference>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF89223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_653077.1"/>
    </dbReference>
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        <property type="protein sequence ID" value="CBF89223"/>
        <property type="gene ID" value="ANIA_00565"/>
    </dbReference>
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        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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        <property type="reaction ID" value="UER00115"/>
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    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00116"/>
    </dbReference>
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        <property type="component" value="Chromosome VIII"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0006207">
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    </dbReference>
    <dbReference type="GO" id="GO:0044205">
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    <dbReference type="GO" id="GO:0006541">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GATase1_CPSase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01423">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1370:FF:000002">
        <property type="entry name" value="Aspartate carbamoyltransferase 2"/>
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    </dbReference>
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        <property type="entry name" value="Aspartate carbamoyltransferase catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Bifunctional pyrimidine biosynthesis protein"/>
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    </dbReference>
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        <property type="entry name" value="CAD protein-like isoform X1"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Carbamoyl-phosphate synthase 1, mitochondrial"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ATP-grasp fold, A domain"/>
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        <property type="entry name" value="Methylglyoxal synthase-like domain"/>
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        <property type="entry name" value="Asp/Orn_carbamoyltranf_P-bd"/>
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        <property type="entry name" value="Asp/Orn_carbamoylTrfase"/>
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        <property type="entry name" value="CarbamoylP_synth_ssu_N"/>
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        <property type="entry name" value="CarbP_synth_ssu_N_sf"/>
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        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
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        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005483">
        <property type="entry name" value="CPSase_dom"/>
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        <property type="entry name" value="CPSase_GATase1"/>
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        <property type="entry name" value="CPSase_lsu_oligo"/>
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        <property type="entry name" value="CPSase_preATP-grasp"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405">
        <property type="entry name" value="CARBAMOYLTRANSFERASE FAMILY MEMBER"/>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="AOTCASE"/>
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        <property type="entry name" value="ATCASE"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Aspartate/ornithine carbamoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48108">
        <property type="entry name" value="Carbamoyl phosphate synthetase, large subunit connection domain"/>
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    </dbReference>
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        <property type="entry name" value="Carbamoyl phosphate synthetase, small subunit N-terminal domain"/>
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    </dbReference>
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        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52335">
        <property type="entry name" value="Methylglyoxal synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00097">
        <property type="entry name" value="CARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51855">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0511">Multifunctional enzyme</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0808">Transferase</keyword>
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        </source>
    </evidence>
    <sequence length="2275" mass="249540" checksum="25F581F3A50BB5CC" modified="2009-05-26" version="2">MPETVGHEEPALPSSPQAGGAVAYNAISKELQPLPPTETANGGIIPPASSRIEGSTGRLCALELEDGTVYQGYNFGAEKSVAGELVFQTGMVGYPESITDPSYRGQILVITFPLVGNYGVPSRETMDELLKTLPKHFESTEIHIAALVVATYAGENYSHFLAESSLGQWLKEQGVPAIHGVDTRALTKRIRQKGSMLGRLLLHKADVAETDAALAQDTWKSSFEQIDWVDPNTKNLVSEVSIREPKLFSPPENVALKHPSSRPIRVLCLDVGLKFNQLRCLVARGVEVLVVPWDYDFPTLAGKDYDGLFVSNGPGDPATMTTTVNNLAKTMQEARTPIFGICLGHQLIARSVGAQTLKMKFGNRGHNIPCTSLVTGKCHITSQNHGYAVDSSTLPSDWQELFVNANDGSNEGIRHVSRPYFSVQFHPESTPGPRDTEYLFDVFINAIKDTIASPEALQKPVNFPGGAVAENIKASPRVSVKKVLILGSGGLSIGQAGEFDYSGSQAIKALKEEGIYTILINPNIATIQTSKGLADKVYFLPVNADFVRKVIKHERPDAIYVTFGGQTALQVGIQLKDEFESLGVKVLGTPIDTIITTEDRELFARSMDSIGEKCAKSASASSLEEALQVVESIGFPVIVRAAYALGGLGSGFADNLDELKDLCAKAFAASPQVLIERSMKGWKEIEYEVVRDARDNCITVCNMENFDPLGIHTGDSIVVAPSQTLSDEDYNMLRTTAVNVIRHLGVVGECNIQYALNPYSKEYCIIEVNARLSRSSALASKATGYPLAFIAAKLGLNIPLNEIKNSVTKVTCACFEPSLDYCVVKIPRWDLKKFTRVSTQLGSSMKSVGEVMAIGRTFEEAIQKAIRSVDFHNLGFNETNALMSIKTELQTPSDQRLFAIANAMAAGYSVDDIWKLTNIDKWFLTRLKGLSDFGKLMTNYNASTVTAPLLRQAKQLGFSDRQLAKFLSSNELAIRRLRVEAGIIPIVKQIDTVAAEFPSVTNYLYLTYNASEHDVRFDDNGIMVLGSGVYRIGSSVEFDWCSVRTIRTLREQGHKTVMVNYNPETVSTDYDEADRLYFENINLETVLDIYQLESSSGVIMSMGGQTPNNIALPLHRLNVRILGTSPEMIDGAENRYKFSRMLDRIGVDQPAWKELTSIEEAREFCDKVGYPVLVRPSYVLSGAAMNTVYSEHDLASYLNQAADVSREHPVVITKYIENAKEIEMDAVARNGVMVGHFISEHVENAGVHSGDATLILPPQDLDPETVRRIEEATRKIGNALNVTGPFNIQFIAKDNDIKVIECNVRASRSFPFVSKVMGVDLIEMATKAMIGAPFAEYPPVTIPKDYVGVKVPQFSFSRLAGADPVLGVEMASTGEVASFGRDKYEAYLKALLSTGFKLPKRNILLSIGSYKEKMEMLPSIIKLRDVGFELFATSGTADFLKENGVPVKYLEILPGEDEDIKSEYSLTQHLANNLIDLYINLPSSNRFRRPANYMSKGYRTRRMAVDYQTPLVTNVKNAKILIEAIARHYALNVQTIDYQTSHRSIILPGLINVGAFVPGLGSADSKDFEAVTKASIAAGFSMIRVMPVGVDSSITDARTLKLVQQNAGKASFCDYNFSVVATSSNSAEVGQLTGEVGSLFIPFNHLSGNISKVAAVTSHFGAWPSSKPIITDAKSTDLASVLLLASLHSRNIHVMSVTSKEDIGLIALSKEKGLKVTCDVSIYCLFLSRDDYPEAAFLPTAEDQKALWEHLSTIDIFSIGSIPYQLAGEKGSPAAGIAEALPLLFTAVSEGRLTVEDIIARLYENPKKIFELHDQSDSSVEVEIDRPYLFQSAQAWSPFSGKSVKGLVQRVIFQGKTSCLDSEITPDAPKGSDMSGHRIVPASPSLKAMSPRVDGALDRRQSISIAGTPARLGRKPVDHFPAATGAELGPPLYTPVPRASSPLLQMLSRSPFKQKHVLSVNQFNRADLHLLFTVAQEMRLGVQREGVLDILKGRLLCTLFYEPSTRTSASFDAAMQRLGGRTIAISTEHSSTKKGETLQDTLRTLGCYGDAVVLRHPEPSSTEVAAKFSPVPVINGGNGSVEHPTQAFLDLFTIREELGTVGGLTITFTGDLKYGRPVHSLIKLLQFYDVRVQLVAPKDLSLPADIRQQLLATGQLLTESEELTPEIVARSDVLYSTRVQKERFADLEQYERLKNSFIIDNALLKHAKSHMVVMHPLPRNAEVSEEVDFDQRAAYFRQVSLQSRGPSSEFDMLMWMQMRYGLYCRMALLALIMAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AQD7</accession>
    <accession>C8VK23</accession>
    <name>Q5AQD7_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_09493</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001306">
        <property type="protein sequence ID" value="CBF82401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_868875.1">
        <property type="nucleotide sequence ID" value="XM_863782.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AQD7"/>
    <dbReference type="GeneID" id="3684092"/>
    <dbReference type="KEGG" id="ani:ANIA_09493"/>
    <dbReference type="eggNOG" id="ENOG502SJAV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060131_6_3_1"/>
    <dbReference type="InParanoid" id="Q5AQD7"/>
    <dbReference type="OMA" id="WRYVKPK"/>
    <dbReference type="OrthoDB" id="410198at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VI"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF2">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13508">
        <property type="entry name" value="Acetyltransf_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="84"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF82401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="222" mass="24815" checksum="46ED4CE4D001F225" modified="2005-04-26" version="1">MPFTICSLLPSDYVEAFTVADLAFASLNTLLYNTYPLSPESTEKLTAARLRDIEAMPRANMFKAVDTETGKIIGVARWVVAKEEEIVDQSIEDTVSNDIMHRTVPETNEASTRGFYTMAARGKWAILGIEDERAEVVRLKRRVELDALFTHPGYQGNGVGSALLQWGLNEADRLGLITYLEATEEGRPLYERFGFEAIKVVEFDAGAFGGVGKHQYTYPREH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="111" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AQP7</accession>
    <accession>C8VRI6</accession>
    <name>Q5AQP7_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Unsaturated rhamnogalacturonan hydrolase (Eurofung)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_09383</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001308">
        <property type="protein sequence ID" value="CBF87511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_682652.1">
        <property type="nucleotide sequence ID" value="XM_677560.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AQP7"/>
    <dbReference type="SMR" id="Q5AQP7"/>
    <dbReference type="CAZy" id="GH105">
        <property type="family name" value="Glycoside Hydrolase Family 105"/>
    </dbReference>
    <dbReference type="GeneID" id="2867803"/>
    <dbReference type="KEGG" id="ani:ANIA_09383"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN9383"/>
    <dbReference type="eggNOG" id="ENOG502QV67">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038720_1_0_1"/>
    <dbReference type="InParanoid" id="Q5AQP7"/>
    <dbReference type="OMA" id="TAWDDIM"/>
    <dbReference type="OrthoDB" id="540611at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VIII"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010905">
        <property type="entry name" value="Glyco_hydro_88"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052043">
        <property type="entry name" value="PolySaccharide_Degr_Enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33886">
        <property type="entry name" value="UNSATURATED RHAMNOGALACTURONAN HYDROLASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33886:SF9">
        <property type="entry name" value="UNSATURATED RHAMNOGALACTURONAN HYDROLASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07470">
        <property type="entry name" value="Glyco_hydro_88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030175711" evidence="2">
        <location>
            <begin position="20"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF87511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="378" mass="42876" checksum="12DC4EC3C061FB2B" modified="2005-04-26" version="1">MKVPTIAKSALLLATAANAANYTEWLAQSFFSKGVTLSRNYAYAVLYTGVEYAYNKTGDPAYFDYIKAQIDGVVNEDGSLVEPITDTLSLDDIRIGRNFLYLWTVTGDKKYKIAADGLRKQLDFTPRNQDGGFWHRKPTYPNQMWLDGLYMASNFYAQWTNWFQPNNKTAWDDIILQYDLIEAHIRDNETGLLFHGYDASKVAVWADPVTGASPHIWSRAVGWYFVSLVELLDYFPKSHPGYKRTLQRYQSLAKAVKKSQDESGGWWLIQDPPYPSDPRNYIESSASAMFTYALLRGIRKGFIPAKEYKPVALDGYSLLKNEFLSHNANGTLNWEGTVQVGSLSGNGTFEYYISVPVVQNDYKGAGPFMYASYELEAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="100" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ARZ0</accession>
    <accession>C8VLB9</accession>
    <name>Q5ARZ0_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ANIA_08940</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001307">
        <property type="protein sequence ID" value="CBF84611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_682209.1">
        <property type="nucleotide sequence ID" value="XM_677117.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ARZ0"/>
    <dbReference type="GeneID" id="2868226"/>
    <dbReference type="KEGG" id="ani:ANIA_08940"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN8940"/>
    <dbReference type="eggNOG" id="ENOG502SU2F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_396367_0_0_1"/>
    <dbReference type="InParanoid" id="Q5ARZ0"/>
    <dbReference type="OMA" id="TCYAHAT"/>
    <dbReference type="OrthoDB" id="3789175at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome VII"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF84611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="702" mass="77582" checksum="87EC7C8C24FD2B5D" modified="2005-04-26" version="1">MANQESSTLVGCLFDVSGSMRKLLKTGQPDGRAVDRFHAVLGAALDIARKEQQSDPRAKMFVGAFGLDRQDGYPPTVDLCGIVEALLEENDQDDRSGHDSLIEIANQNNLAHITEYIRNKLTDSVARIVHACLRRCPERIHEFKDAIPSAAEIRKSQTMKNGATFGGGAVAIGVGSLVCGPLGGLLGAALTAGGAMSADAYADEVVDSSEGLMLARRICREWFRDFADFIPRPVSDVVRLLQLLQQRSTRARQWLSVEEFVYGDTPMREALSRSLSVFQANSDCDQRVLVLMSDGHATDGDPGEIATELHSEGVAVASVYLTSDTDIAQRRLYDKPAYSWDKGQRTLFNIASKVSASNHPIPVLMSVGWQIPCSGEVALYVCVCTEPAVEEFCSLLVSAHLASTDALLDVIGRLQLDDYIQDELAITCKNPSDQGSSATCYAHAIAAVIHMALLRIERKEPCPTIKEIRDRILHEFPPGDHGRVAEEVLNQAVQWYRLRYRAVDEMRARQAVLQRRPVLTTFRLSEKGWAKFSQYFSQPQTRRSMLTEANMRPYRQGPDGGGHAVVLYACDPRSLSFLNSWGSDWGTNGGFRVQSPAVLEIDEPDCLSPVHFYDVFWYESDLTPSERAAYDAKAEEKLRAYTTYHPSLLELEAMCPLCQRISLISDFTGNAREAKCPRCLFSFVPQPGSLLQVLYARAGLGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="103" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ASD6</accession>
    <accession>C8V9P4</accession>
    <name>Q5ASD6_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNase III domain protein (AFU_orthologue AFUA_5G09670)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_08794</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF78007.1"/>
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        <property type="nucleotide sequence ID" value="XM_676971.1"/>
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    <dbReference type="GeneID" id="2868401"/>
    <dbReference type="KEGG" id="ani:ANIA_08794"/>
    <dbReference type="eggNOG" id="ENOG502RXWY">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_057354_0_0_1"/>
    <dbReference type="InParanoid" id="Q5ASD6"/>
    <dbReference type="OMA" id="AHTMYAV"/>
    <dbReference type="OrthoDB" id="2281895at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="F:structural constituent of ribosome"/>
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        <property type="entry name" value="RNase_III_sf"/>
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        <property type="entry name" value="54S RIBOSOMAL PROTEIN L15, MITOCHONDRIAL"/>
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        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML57"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF14622">
        <property type="entry name" value="Ribonucleas_3_3"/>
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        <property type="entry name" value="RNase III domain-like"/>
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    <feature type="domain" description="RNase III" evidence="1">
        <location>
            <begin position="104"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF78007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="246" mass="27474" checksum="8E3756BF383B7CC6" modified="2005-04-26" version="1">MASLLPIRAFRTASCSACRSLISSGPAQLALPLSRRNYSTPAEQEPVDYTNKPRWSYTPPRAKAPFSLHFDSKRPDFPVNSDPQVLDQFYIRFLGEGGDKVLSDEVKWLAVTHKSFDQGRRGFNDRLAFLAQSASNSYGQPAPDRYGRKPFEHPALNGLENLSINTKRFLTDKSKLAEVARQYDLEKVLRWCPRKPTNLEASGVEVVLAHTLYALIGALSLEKGNLVANKVARERILAPLGFQVTV</sequence>
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    <accession>Q5ASJ6</accession>
    <accession>C8VA10</accession>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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        <name evidence="1" type="ORF">ANIA_08734</name>
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        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
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            <taxon>Fungi</taxon>
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            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="2">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF78138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_682003.1">
        <property type="nucleotide sequence ID" value="XM_676911.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ASJ6"/>
    <dbReference type="GeneID" id="2868399"/>
    <dbReference type="KEGG" id="ani:ANIA_08734"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN8734"/>
    <dbReference type="HOGENOM" id="CLU_2171034_0_0_1"/>
    <dbReference type="InParanoid" id="Q5ASJ6"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CBF78138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="110" mass="12429" checksum="A8DEB9D6B75EF04E" modified="2005-04-26" version="1">MATFAASSLEACSSEIAETFIVPLAKPKSYWRFWPTLFIQSDVQCTEQAVRMMIDAHSPDPTVSPVSRFSWVTFSALTLISSRIWSLFVSMNQSARHAVKLASVTDQYYR</sequence>
</entry>
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    <accession>Q5ASW9</accession>
    <accession>C8VAF8</accession>
    <name>Q5ASW9_EMENI</name>
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        <recommendedName>
            <fullName evidence="1">Nucleoside phosphorylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_08611</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001303">
        <property type="protein sequence ID" value="CBF78331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="XP_681880.1">
        <property type="nucleotide sequence ID" value="XM_676788.1"/>
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    <dbReference type="AlphaFoldDB" id="Q5ASW9"/>
    <dbReference type="STRING" id="227321.Q5ASW9"/>
    <dbReference type="GeneID" id="2868559"/>
    <dbReference type="KEGG" id="ani:ANIA_08611"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN8611"/>
    <dbReference type="eggNOG" id="ENOG502SHMZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_34_22_1"/>
    <dbReference type="InParanoid" id="Q5ASW9"/>
    <dbReference type="OMA" id="SFEMSAV"/>
    <dbReference type="OrthoDB" id="1577640at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome III"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF11">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleoside phosphorylase" evidence="1">
        <location>
            <begin position="38"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF78331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="343" mass="37885" checksum="3A9426715774863E" modified="2005-04-26" version="1">MRSQRPGSHLNYESYTVALICPLEVDLTAARCMLDEEHGRVPGNNIDPNSYLLGTLSGHNVVLTSLLEGSQGPNAAALVAAHLLRTFTAVELRLLVGCAGGVPSRNTDIRLGDVVVSTPTETSGGVVQYDMVRETVAGSQRKGLICPPPAPWRSIITKMKSDHRLRANRIDEFTSRMMHKHPELKAYWRPPPERDVLFAADYNHTVAEAPCTHCDSNKYVARVRRTQPMKSEIFYGLIASGNRVIKNGLKRDILAQEAGGAICFDMEAAGLMNDFQCVVVRGIANYCDSHKNDEWNGYAAAAAAAVAKEMLTYILPVEPVMRMDTLRLRDRRLGFSGELRTYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="126" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AT92</accession>
    <accession>C8VEK2</accession>
    <name>Q5AT92_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Synaptobrevin homolog YKT6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">ANIA_08488</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="14">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the synaptobrevin family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF80654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_681757.1">
        <property type="nucleotide sequence ID" value="XM_676665.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AT92"/>
    <dbReference type="FunCoup" id="Q5AT92">
        <property type="interactions" value="1205"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5AT92"/>
    <dbReference type="GeneID" id="2868603"/>
    <dbReference type="KEGG" id="ani:ANIA_08488"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN8488"/>
    <dbReference type="eggNOG" id="KOG0861">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074848_0_1_1"/>
    <dbReference type="InParanoid" id="Q5AT92"/>
    <dbReference type="OMA" id="HYIGIIR"/>
    <dbReference type="OrthoDB" id="27923at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000421">
        <property type="term" value="C:autophagosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033106">
        <property type="term" value="C:cis-Golgi network membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016409">
        <property type="term" value="F:palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061909">
        <property type="term" value="P:autophagosome-lysosome fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042144">
        <property type="term" value="P:vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd14824">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15867">
        <property type="entry name" value="R-SNARE_YKT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000020">
        <property type="entry name" value="synaptobrevin homolog YKT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.50">
        <property type="entry name" value="Longin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010908">
        <property type="entry name" value="Longin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045848">
        <property type="entry name" value="R-SNARE_YKT6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001388">
        <property type="entry name" value="Synaptobrevin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45806">
        <property type="entry name" value="SYNAPTOBREVIN HOMOLOG YKT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45806:SF1">
        <property type="entry name" value="SYNAPTOBREVIN HOMOLOG YKT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13774">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00219">
        <property type="entry name" value="SYNAPTOBREVN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01270">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50859">
        <property type="entry name" value="LONGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00417">
        <property type="entry name" value="SYNAPTOBREVIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="8" id="KW-0636">Prenylation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Longin" evidence="11">
        <location>
            <begin position="7"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="12">
        <location>
            <begin position="137"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CBF80654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="197" mass="21876" checksum="9A21A6CAF78F173B" modified="2005-04-26" version="1">MKIVYIGVLRNAQPDPIELCCERELSSYSRFTRGSIAEFTTMFSKLLTGRTSPGQRQDVQEKDFTFHVYASSASPGITGVIISDDEYPSMAAHQILSKLLDEFTTQNPSATSATGPVSFPALTSYITKYQDPQNVGSILKIQKELDETKVVLHKTIESVLQRGEKLDDLVQKSEGLSSQSKMFYTSAKKQNSCCIIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ATC4</accession>
    <accession>C8VEG8</accession>
    <name>Q5ATC4_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_08456</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF80591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_681725.1">
        <property type="nucleotide sequence ID" value="XM_676633.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ATC4"/>
    <dbReference type="STRING" id="227321.Q5ATC4"/>
    <dbReference type="GeneID" id="2868741"/>
    <dbReference type="KEGG" id="ani:ANIA_08456"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN8456"/>
    <dbReference type="eggNOG" id="ENOG502QZQY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013929_6_1_1"/>
    <dbReference type="InParanoid" id="Q5ATC4"/>
    <dbReference type="OMA" id="TIELTIX"/>
    <dbReference type="OrthoDB" id="4509955at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF80591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="193" mass="22570" checksum="91C4A6D843D8504E" modified="2005-04-26" version="1">MHHLSTENILLKARCEGLEEALVNERKRRKRGKPLIFQLQAPEAGNAVFYSPRRIQQARDLQKEKDEAIQQAKAAKKEAKLYRQQEKEEKQRNTEKRRRIKALERQIRLQEAEKKKLEKEQQKEEARIAKEAVIQLQNNIRTARQSKSKLPATPKAPEKQKPSCPAPEAIPGTSTTINRRGRQIRLPRRFRNS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2016-11-30" modified="2025-04-09" version="108" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ATG7</accession>
    <accession>C8VEB4</accession>
    <name>APDF_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aspyridones efflux protein apdF</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Aspyridones biosynthesis protein F</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">apdF</name>
        <name type="ORF">AN8413</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2007" name="Nat. Chem. Biol." volume="3" first="213" last="217">
            <title>Genomics-driven discovery of PKS-NRPS hybrid metabolites from Aspergillus nidulans.</title>
            <authorList>
                <person name="Bergmann S."/>
                <person name="Schuemann J."/>
                <person name="Scherlach K."/>
                <person name="Lange C."/>
                <person name="Brakhage A.A."/>
                <person name="Hertweck C."/>
            </authorList>
            <dbReference type="PubMed" id="17369821"/>
            <dbReference type="DOI" id="10.1038/nchembio869"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INDUCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Efflux pump that may be involved in the secretion of aspyridones (PubMed:17369821).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="4">Expression is positively regulated by the aspyridones cluster specific transcription regulator apdR (PubMed:17369821).</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF80489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AACD01000153">
        <property type="protein sequence ID" value="EAA67035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_681682.1">
        <property type="nucleotide sequence ID" value="XM_676590.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5ATG7"/>
    <dbReference type="SMR" id="Q5ATG7"/>
    <dbReference type="STRING" id="227321.Q5ATG7"/>
    <dbReference type="GlyCosmos" id="Q5ATG7">
        <property type="glycosylation" value="2 sites, No reported glycans"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CBF80489">
        <property type="protein sequence ID" value="CBF80489"/>
        <property type="gene ID" value="ANIA_08413"/>
    </dbReference>
    <dbReference type="KEGG" id="ani:ANIA_08413"/>
    <dbReference type="eggNOG" id="KOG2504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_1_1_1"/>
    <dbReference type="InParanoid" id="Q5ATG7"/>
    <dbReference type="OMA" id="ITFCWIR"/>
    <dbReference type="OrthoDB" id="6499973at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd17352">
        <property type="entry name" value="MFS_MCT_SLC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF281">
        <property type="entry name" value="ASPYRIDONES EFFLUX PROTEIN APDF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000438460" description="Aspyridones efflux protein apdF">
        <location>
            <begin position="1"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="119"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="146"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="179"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="211"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="293"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="322"/>
            <end position="342"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="385"/>
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            <begin position="1"/>
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            <begin position="1"/>
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            <position position="67"/>
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            <position position="319"/>
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    <evidence type="ECO:0000255" key="1"/>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="17369821"/>
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    </evidence>
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        <source>
            <dbReference type="PubMed" id="17369821"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EAA67035.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000005890"/>
        </source>
    </evidence>
    <sequence length="487" mass="52253" checksum="3F4CA34360C8EEDD" modified="2005-04-26" version="1">MSSVRESSKDESIVHPPKAPESEPFPDGGARAWMVALGAGGVLFCTFGYVNAFGVYQDYYITHQLSNYSASDIAWIGSVQTFFLFGSGLVGGPLFDRYGAKVIWAPAVLVIFSVMMTSLCTKFYQFFLAQGILGGMSMGLSLAPALSSTAQYFQKKRAAAMGITIAGSSLGGVIFPIALEQMLYSSLGFAWAVRIVGFIILGVMSFAVLGIRARLPPKRQRFLKLEAFKKTHYVATLTAVFFLNVGIFTPFFYLPLYGQSHGMSTGLAFYLIAIQNASSFFGRLVPGVIADKIGPYNMLSTVSIITAIITFCWIRMTTNASIIVFSVLYGFFSGGIIGITPAAIANCAGHPQEIGTYIGMGMAVMSVATLIGPPINGALLNEYGGFLQVQIFSAAVMMFGGVLAFGAKMISFSGEGKGMRKFDHAVAGLAYYVREGGSRMEHIYFGSVAIVAGHLHGPVCAQNKRQMLVTGIGAEMVYVLEYFVEAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>Q5ATY3</accession>
    <accession>C8V7H3</accession>
    <name>Q5ATY3_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF1665 domain protein (AFU_orthologue AFUA_5G03870)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_08247</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRP15 family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_676424.1"/>
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    <dbReference type="KEGG" id="ani:ANIA_08247"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN8247"/>
    <dbReference type="eggNOG" id="KOG2974">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058264_1_2_1"/>
    <dbReference type="InParanoid" id="Q5ATY3"/>
    <dbReference type="OMA" id="FVKQRFY"/>
    <dbReference type="OrthoDB" id="20949at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="term" value="P:maturation of LSU-rRNA"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012459">
        <property type="entry name" value="Rrp15"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13245">
        <property type="entry name" value="RRP15-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13245:SF14">
        <property type="entry name" value="RRP15-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07890">
        <property type="entry name" value="Rrp15p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="71"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="81"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF74201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="283" mass="31099" checksum="3CBB498B33CFFC7C" modified="2005-04-26" version="1">MPLTTSQKKRKVLEGFQGKTGRPNKKFRKQREYHSSSDEADDEPADFKAVDLADSDEETEEPARKQQKQTKSKEAKKPEPQEDSSSEDDESASNDDSDVDDDTDDDAHSDGSTPTGAIGKRTVPKRNDPTAFSTSISKILATKLPTSARADPVLSRSKTVTQITSQIAEEKLDNAARAKLRAEKKEELDRGRVRDVRGISTGQAGAVAEEEKRLRKIAQRGVVKLFNAVRAAQVRGEEAAKEERKKGTVGIGEREKAVNQVSKQGFLELINGKKGKPLNIEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AUE4</accession>
    <accession>C8V6E8</accession>
    <name>Q5AUE4_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_08086</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF73856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_681355.1">
        <property type="nucleotide sequence ID" value="XM_676263.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AUE4"/>
    <dbReference type="GeneID" id="2869259"/>
    <dbReference type="KEGG" id="ani:ANIA_08086"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN8086"/>
    <dbReference type="eggNOG" id="ENOG502RNWF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1669987_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AUE4"/>
    <dbReference type="OMA" id="YQGIPDN"/>
    <dbReference type="OrthoDB" id="2408539at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="AspGD"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010299492" evidence="1">
        <location>
            <begin position="19"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF73856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="153" mass="16908" checksum="61E4C414AA1FCE86" modified="2005-04-26" version="1">MKLTAAVVTGLLATSTSAAFDKWAPWGKRDYSCINAYSGPTENSTLTTGTPLEIKFNRNSGRCDSLNDYPTGNYSLWLHNNPVRNMGFVNSDYQVKIQDGISSDATSVTFTLPDDLPEVADDTVWYLRLDTYLPTAPQMPSLFNALGPFRIVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="116" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AV25</accession>
    <accession>C8V3L6</accession>
    <name>Q5AV25_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">fatty-acyl-CoA synthase system</fullName>
            <ecNumber evidence="1">2.3.1.86</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ANIA_07855</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="11">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>acetyl-CoA + n malonyl-CoA + 2n NADPH + 4n H(+) = a long-chain-acyl-CoA + n CoA + n CO2 + 2n NADP(+).</text>
            <dbReference type="EC" id="2.3.1.86"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">[Alpha(6)beta(6)] hexamers of two multifunctional subunits (alpha and beta).</text>
    </comment>
    <dbReference type="EC" id="2.3.1.86" evidence="1"/>
    <dbReference type="EMBL" id="BN001302">
        <property type="protein sequence ID" value="CBF73392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_681124.1">
        <property type="nucleotide sequence ID" value="XM_676032.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AV25"/>
    <dbReference type="STRING" id="227321.Q5AV25"/>
    <dbReference type="GeneID" id="2869304"/>
    <dbReference type="KEGG" id="ani:ANIA_07855"/>
    <dbReference type="eggNOG" id="ENOG502SKWI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_467702_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AV25"/>
    <dbReference type="OMA" id="ANEWALP"/>
    <dbReference type="OrthoDB" id="4251012at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome II"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005835">
        <property type="term" value="C:fatty acid synthase complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004321">
        <property type="term" value="F:fatty-acyl-CoA synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042759">
        <property type="term" value="P:long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.60.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039569">
        <property type="entry name" value="FAS1-like_DH_region"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050830">
        <property type="entry name" value="Fungal_FAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10982:SF21">
        <property type="entry name" value="FATTY ACID SYNTHASE SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10982">
        <property type="entry name" value="MALONYL COA-ACYL CARRIER PROTEIN TRANSACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13452">
        <property type="entry name" value="FAS1_DH_region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22235">
        <property type="entry name" value="FAS1_thioest_ins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FAS1-like dehydratase" evidence="9">
        <location>
            <begin position="4"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="MaoC-like" evidence="8">
        <location>
            <begin position="164"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Malonyl-CoA:ACP transacylase (MAT)" evidence="7">
        <location>
            <begin position="238"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="482"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="489"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="532"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00033756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBF73392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="583" mass="64363" checksum="88D174EFCFE0072B" modified="2005-04-26" version="1">MASLDVGIIVAWEALLRSLLSPGLGGDLSRLLHISNTFEPVPGMEPLRVGDLLKTTLRITAVTIKPLGKLVEVTVVIKREEASIMKITSEFLIQGQFPHHHQSFPSSEANEWALPLDSPKAVVLLRSRPWFKPDAKCPELLDKTLLFRITSQSSKMFTLNTSGFAGLSTTIVHGMNTSAVVRSMIEDHLAKTGCAKFCRWSTTFEDVVRGGDRLRIELQHQGMISGNMALEVQAPTAYPFCGQGSQKKEMGMAIYETDGSAKSAWHRGHRYLFELYDPALISPQGFSLLNIVRNNPKSLTVYFGTTKGRQIRANYLALARTEVINGREITVPVVDGLSESSSSITFEEPNGLLFSTQFAQLAISLMNIAESSALKARGLFQQGAAFAGHSLGEYSALLACADFMSLENLLSVLPFGFFIFFHSTPTAPSRLIDAALLRHQVSKRRCPSMDDTLWTDARDFELKKTYAKPVEKLVAHPLRSGRVQVEEQTEPRAYRHDDRTGYKEGEAHAMGKDDKEGDVAAIRPGASCTTPRKREEEADNGRNEDDGADGIKAPEYLPPGLLALPLWLQPEKQQTDGRYAAQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="155" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AVF1</accession>
    <accession>C8VDJ3</accession>
    <name>Q5AVF1_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="17">ABC metal ion transporter (Eurofung)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">ANIA_07729</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="18">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF79986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_680998.1">
        <property type="nucleotide sequence ID" value="XM_675906.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q5AVF1">
        <property type="interactions" value="295"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5AVF1"/>
    <dbReference type="GeneID" id="2869402"/>
    <dbReference type="KEGG" id="ani:ANIA_07729"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN7729"/>
    <dbReference type="eggNOG" id="KOG0054">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_27_3_1"/>
    <dbReference type="InParanoid" id="Q5AVF1"/>
    <dbReference type="OMA" id="CFETGMR"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042592">
        <property type="term" value="P:homeostatic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd18595">
        <property type="entry name" value="ABC_6TM_MRP1_2_3_6_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18603">
        <property type="entry name" value="ABC_6TM_MRP1_2_3_6_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000565">
        <property type="entry name" value="ABC bile acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000020">
        <property type="entry name" value="ABC metal ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000450">
        <property type="entry name" value="ABC transporter C family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000001">
        <property type="entry name" value="ATP-binding cassette subfamily C member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056227">
        <property type="entry name" value="TMD0_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF443">
        <property type="entry name" value="MULTIDRUG-RESISTANCE LIKE PROTEIN 1, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24357">
        <property type="entry name" value="TMD0_ABC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-1278">Translocase</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="151"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="341"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="436"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="559"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="962"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1005"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1091"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1195"/>
            <end position="1213"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="16">
        <location>
            <begin position="302"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="15">
        <location>
            <begin position="622"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="16">
        <location>
            <begin position="966"/>
            <end position="1249"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="15">
        <location>
            <begin position="1286"/>
            <end position="1521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="850"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="859"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="879"/>
            <end position="890"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CBF79986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="1535" mass="171784" checksum="30CB322361B078B2" modified="2005-04-26" version="1">MLDDSTQTVLGAIVPESLSSTSFQQYAQLQPFCGDVEGWGPLSRLRFDLTPCFLDVGVSVVALFGLVLGSGALWFLLNKRIPQPVSKNWHFYAKLVVLSALLFTTALQAALQVEIYASWFADFRFWSTVLVFASLCVIFAVQYYEHWRSRYPNGVVLFYWLFFIIAYTVKLRSHVARKTYDDRLPSFVCLNVSLGLAILEFLLEYLVPKKQSAYDALGDEDECPYEYADVFSVLTFSWMTPMMKFGYKNFLTQDDLWNLRRRDTTRATGATLEENWEYELQKDKPSLWTALFKSYGGPYVRGAIIKCGSDILAFVQPQLLRLLINFIDSYRTTEPQPVIRGVAISLAMFVVSVSQTSFLHQYFQRAFDTGMRVKSGLTAMIYAKSLRLSSEGRASKTTGDIVNHMAVDQQRLSDLTQFGTQLWSAPFQITLCMISLYQLVGVSMFAGIGVMILMIPLNGVIARMMKKLQLVQMKNKDARSRLMTEILNNIKSIKLYAWNTAFMNKLSHIRNDLELNTLRKIGATQSVANFTWQSTPFLVSCSTFTVFVLTEDRPLTTSIVFPALTLFNLLTFPLSILPMVITSVIEASVAVRRLTDYFAAEELQTDAVKNEDPVSHIGDESVRIREASFSWDRYKDDTVLENIDLSCRKGELNCIVGRVGSGKSSLLQALLGDLWKTEGEVVVRGRIAYVAQAAWVMNASVRENIVFGHRWDPQFYELTVEACALLDDFKNLPDGDQTEVGERGISLSGGQKARLTLARAVYARADIYLLDDVLSAVDQHVGRHLINRVLGRNGILNSKTRILATNAIPVLKEADFIGLLRDKTLIEKGTYEQLMAMKGEVANLVRTTLNESGDEDSSAESGGLASLESSETTTIIEGPDSDFSDTDEAEQQIGSLAPIKAAGPRRTSTVTLRRASTVSWQGPRRKLGDEENVLKSKQTQETSQQGKVKWSVYGEYAKNSNLIAVAFYLVTLVGAQTAQVGGSYWLKHWTEVSERQSAPNAGKFIGIYLALGLGSSFLVILQNLILWIFCSIEASRKLHERMAFSIFRSPMRFFETTPSGRVLNRFSSDIYRIDEVLARTFNMLFGNSAKAIFTLLVIANSTPPFLIAVIPLGYIYFSYQKYYLRTSRELKRLDSVTRSPIYAHFQESLGGISTIRAYRQEERFSLENEWRMDANLRAYFPSISANRWLAVRLEFIGSVIILVSALLSIVSVATGSKLSAGMVGLAMSYALQITQSLNWIVRQTVEVETNIVSVERVLEYASLPSEAPEVIFKNRPPTGWPAQGAVSFHNYSTRYREGLDLVLKDVNLDIKPREKIGVVGRTGAGKSSLTLALFRIIEPTNGGISIDNLDISTIGLRDLRGRLAIIPQDPAMFEGTVRDNLDPRHVHDDTELWSVLEHARLKEHVSQMQGQLDAHIQEGGSNLSQGQRQLISLARALLTPSNILVLDEATAAVDVETDALLQRTLRSSIFQDRTIITIAHRINTIIDSDRIVVLDKGRVAEFDSPAALIKQRGKFYDLVKEAGLLDSDGNAITVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AVZ9</accession>
    <accession>C8VC66</accession>
    <name>Q5AVZ9_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_07531</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF79577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_680800.1">
        <property type="nucleotide sequence ID" value="XM_675708.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AVZ9"/>
    <dbReference type="KEGG" id="ani:ANIA_07531"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN7531"/>
    <dbReference type="HOGENOM" id="CLU_1165802_0_0_1"/>
    <dbReference type="InParanoid" id="Q5AVZ9"/>
    <dbReference type="OrthoDB" id="4504314at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF79577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="238" mass="26520" checksum="A597EDB0881D8F8E" modified="2005-04-26" version="1">MVWKILWRALCRLEWSVTTGCCWCAFALASPIVARLAFKLFSVRLTGNRRVTDCQEVVSAVLAFSWDSHVVTHHTTNQPACGLSTAERTGSPVFHTLWSYVPGLSGLKNISLGIGFKASNPTWKADALNLVPATAQKEQNRNPNVKLGTGNTQRPSHVQHKGYRLLQRRSGICEEHELTARNRKKQEYTGCGCIGCMSIHHALNFALKRRYSSGGIRHWTMLTRRDGEGSVREAFLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="114" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AX67</accession>
    <accession>C8VDC0</accession>
    <name>Q5AX67_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cysteine synthase B, putative (AFU_orthologue AFUA_4G03930)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_07113</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF79057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_664717.1">
        <property type="nucleotide sequence ID" value="XM_659625.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AX67"/>
    <dbReference type="STRING" id="227321.Q5AX67"/>
    <dbReference type="GeneID" id="2869867"/>
    <dbReference type="KEGG" id="ani:ANIA_07113"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN7113"/>
    <dbReference type="eggNOG" id="KOG1481">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039949_1_0_1"/>
    <dbReference type="InParanoid" id="Q5AX67"/>
    <dbReference type="OMA" id="MPALNML"/>
    <dbReference type="OrthoDB" id="10259545at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004122">
        <property type="term" value="F:cystathionine beta-synthase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00158">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.250.10:FF:000057">
        <property type="entry name" value="Cysteine synthase B, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000058">
        <property type="entry name" value="Cysteine synthase B, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050214">
        <property type="entry name" value="Cys_Synth/Cystath_Beta-Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10314">
        <property type="entry name" value="CYSTATHIONINE BETA-SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="381"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF79057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="522" mass="58116" checksum="A76C58E6A8E68736" modified="2005-04-26" version="1">MANLNGLNVYFGQDSLKKYFNPDEQPPLPLVELPEYLNPYYQDGVRIYAKMMTMHPANNVKAMPAMNMLESNVVPGKTKTIIEYSSGSTVISMSMIARVMHGIGDTRAYLSNKTSDAKLKLMQFFGLNISLFGGPSQPEPYDERGGIQSARRMATESDEILNPNQYENDKNWQSHIRWTGPQIFKQLPEITVLCAGMGTSGTMTGLGTYFKQVKPTVLRLGVCTAPGDRVPGPRSFALMKPVEFPWKEAVDVIEEVNSYDSFSLSLDLCREGIVCGPSSGFNLQGLFQMLEKRKKEGTLSELAGPDGVTHCVFLCCDLPYQYIGEYFSRLGEDKFHPIKNENLARVDLYRYDESWERSPIVLFTHFYSSPTSHNLMDNLTLRPNTCVLDIRTAPDFAQWHLPGSVNYPLKSLTSHTPKPFSNPAVLEAQWLELESLLNKESVLSKLGNQHVLVICYHGDTARVATSVLRAQGIQADSLRGGYQALRDQGLWGDGGVEEIANRNGTGEKLPPAVSVAPIELTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="110" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AXA6</accession>
    <accession>C8VDG4</accession>
    <name>Q5AXA6_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Oxidoreductase, short chain dehydrogenase/reductase family, putative (AFU_orthologue AFUA_4G00940)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ANIA_07074</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="5">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001304">
        <property type="protein sequence ID" value="CBF79138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_664678.1">
        <property type="nucleotide sequence ID" value="XM_659586.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AXA6"/>
    <dbReference type="GeneID" id="2869981"/>
    <dbReference type="KEGG" id="ani:ANIA_07074"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN7074"/>
    <dbReference type="eggNOG" id="KOG1205">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_8_2_1"/>
    <dbReference type="InParanoid" id="Q5AXA6"/>
    <dbReference type="OMA" id="ADFLVWI"/>
    <dbReference type="OrthoDB" id="1933717at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome IV"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42901">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42901:SF1">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="3">
        <location>
            <begin position="31"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBF79138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="310" mass="32334" checksum="F62FA82B6248C4B2" modified="2005-04-26" version="1">MAAPPSYTKVTHSATYPAINPSQPALSTAGKVVLITGASGGIGRATASSFAASGPRALILLGRRADALAETAAIVRASYAEVTVQTHEAELCDASSVRNAMNKAAAEFGGIDILVHCAGSLAPVVPLVEADPATFLDGYKTTVVGTLATAQAVVLANRTVSADEDKPVTFINLTTAGILFPPFPGMGAYVSSKMAAVKILEAFAAENPHVRLHNVHPGFLETAMSAKLGEKIKLPYAYDDISLPADFLVWTASAEAEFLRNKIVFAAWDVDELKARTKEIVGGPPGTGELRIGFQGFPRFMAGQPLPGTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AXM7</accession>
    <accession>C8V387</accession>
    <name>Q5AXM7_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7587 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_06953</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF71813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_664557.1">
        <property type="nucleotide sequence ID" value="XM_659465.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AXM7"/>
    <dbReference type="GeneID" id="2870428"/>
    <dbReference type="KEGG" id="ani:ANIA_06953"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN6953"/>
    <dbReference type="eggNOG" id="ENOG502SJQX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048301_1_0_1"/>
    <dbReference type="InParanoid" id="Q5AXM7"/>
    <dbReference type="OMA" id="LNDHLWW"/>
    <dbReference type="OrthoDB" id="4152607at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056009">
        <property type="entry name" value="DUF7587"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24494">
        <property type="entry name" value="DUF7587"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7587" evidence="1">
        <location>
            <begin position="42"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF71813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="436" mass="49917" checksum="927673F00D400576" modified="2005-04-26" version="1">MDALTQVLESTHLDSSPSQHPEQLLFNPSPDSNLAQHALDNIPRYLFRIVSPKSDGQTDAEWVRSKAATLKTYSSRKDIFANLNPENRKVVACTLNRHLRWWPKDDFHDNFVSWTSSLLFALQFIYYRHQSTKDGSALHDIRLYVVDTTRFPRGTFLRDLDLIDAFCGFDVSEPPGKNLRDFRKLRNGHTWYFGEYLSQGSLRIAGKHQCISASSLFQDRLLYRLQPLFPDIQIRADDGPRWAREVVRFREQFMCASLSGDEIRNRFAALGDIMRLIDRKWKFPLAVHFAGLIGPRAEDEGAATLGDFFRCEDIQAEIERVTLSELHLIAPDTMPELTRAKEIVHDVYIDFLARRADEFARQAEMLVCHLRTEHVAELEHAFPVAGSKQIMYTLLAKTLLSQFGQLRAACESVVDAYAFGRVIGHSLQSVMGSIRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="113" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AXR1</accession>
    <accession>C8V301</accession>
    <name>Q5AXR1_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNA annealing protein Yra1, putative (AFU_orthologue AFUA_5G13860)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ANIA_06919</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
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    <reference evidence="6" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
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            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
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        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="6">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
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        <source>
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    </evidence>
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    </evidence>
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    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
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            <dbReference type="DOI" id="10.1038/nature04341"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
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    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
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                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
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                <person name="Visser J."/>
                <person name="Oliver S.G."/>
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        <scope>GENOME REANNOTATION</scope>
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            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
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        <source>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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        <source>
            <dbReference type="EMBL" id="CBF71236.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
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    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
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    <accession>C8V1K9</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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        <name evidence="2" type="ORF">ANIA_06674</name>
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        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
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            <taxon>Eurotiomycetidae</taxon>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
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            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
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            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF71224.1"/>
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        <property type="nucleotide sequence ID" value="XM_659186.1"/>
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    <dbReference type="KEGG" id="ani:ANIA_06674"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN6674"/>
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        <source>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="137" mass="14543" checksum="FEC536D14BFC05C2" modified="2005-04-26" version="1">MSGAADDRSSWRGGRAFDQNRQSGQRQPNSRTMSAHGGSRGGQQSSNTSHTSWADEVTAASQDQHTPVGGFNAAEAKTALRRAPKPYFYKAQGKDANNRASGPWGSNPNTMASGKDFFLELRKQVTALRQGGSVAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AZF2</accession>
    <accession>C8V113</accession>
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        <submittedName>
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    </gene>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
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    <reference evidence="8" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
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                <person name="Asai K."/>
                <person name="Machida M."/>
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                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
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            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
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                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
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            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
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        <property type="protein sequence ID" value="CBF69691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="XP_663932.1">
        <property type="nucleotide sequence ID" value="XM_658840.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AZF2"/>
    <dbReference type="FunCoup" id="Q5AZF2">
        <property type="interactions" value="580"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5AZF2"/>
    <dbReference type="GeneID" id="2870971"/>
    <dbReference type="KEGG" id="ani:ANIA_06328"/>
    <dbReference type="eggNOG" id="KOG2641">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012923_4_2_1"/>
    <dbReference type="InParanoid" id="Q5AZF2"/>
    <dbReference type="OMA" id="PARQTHV"/>
    <dbReference type="OrthoDB" id="5348404at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005178">
        <property type="entry name" value="Ostalpha/TMEM184C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23423">
        <property type="entry name" value="ORGANIC SOLUTE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03619">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01417">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="107"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="262"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="326"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="420"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="278"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="345"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="361"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="388"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="481"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBF69691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="490" mass="55294" checksum="D85827A044F7E4B4" modified="2005-04-26" version="1">MHGRPPVQHAWPLNHILSKVDISDPYTFLNVKRGILQYTWLKPVLAIVSIVMKATDTYKEGYLGLSSGYLWTGILYNISVTISLYSLALFWVCLHHDLAPFRPVPKFLCVKLIIFASYWQGFFLSILQWLGALPNGTGDYTPDNLAAAIQDSLTCFEMPVFAVAHWYAFSWHDYADSTISAARLPVKYALRDAFGAKDLIEDTKMTMRGENYAYRLFDSGDHIIPHAESNSRVRRVMHGMRYERGGKAKYWIPQPGEVNSRTPLLGGFDGSSGSRRNSTLDRYRSHSESEETTLDDSDERLFSQARELEFGDFNYPVITANLVPRDQRLASPAPSRSTQQPTLVKKARKNRKSHASSSGRKTSEGHASRSSRQERSETSKLQRRGTDSPKSPGSHRSQLVDLVVEDREAEEEERAQIQRAFGSVAVEDEPKHFQRPSGDPVDGGATKDAEGNAESTIKQQRLGELEDEGTSPKTPAWDYRDLEEDNVWSR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-03-21" modified="2026-01-28" version="110" xmlns="https://uniprot.org/uniprot">
    <accession>Q5AZH4</accession>
    <accession>C8V186</accession>
    <name>TIM13_EMENI</name>
    <protein>
        <recommendedName>
            <fullName>Mitochondrial import inner membrane translocase subunit tim13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">tim13</name>
        <name type="ORF">AN6306</name>
    </gene>
    <organism>
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. The TIM8-TIM13 complex is non essential and only mediates the import of few proteins, while the predominant TIM9-TIM10 70 kDa complex is crucial and mediates the import of much more proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterohexamer; composed of 3 copies of TIM8 and 3 copies of TIM13, named soluble 70 kDa complex. Associates with the TIM22 complex, whose core is composed of TIM22 and TIM54. Interacts with the transmembrane regions of multi-pass transmembrane proteins in transit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. However, during the transit of TIM13 from cytoplasm into mitochondrion, the Cys residues probably coordinate zinc, thereby preventing folding and allowing its transfer across mitochondrial outer membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small Tim family.</text>
    </comment>
    <dbReference type="EMBL" id="AACD01000107">
        <property type="protein sequence ID" value="EAA58690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BN001301">
        <property type="protein sequence ID" value="CBF69740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_663910.1">
        <property type="nucleotide sequence ID" value="XM_658818.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5AZH4"/>
    <dbReference type="SMR" id="Q5AZH4"/>
    <dbReference type="FunCoup" id="Q5AZH4">
        <property type="interactions" value="425"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5AZH4"/>
    <dbReference type="EnsemblFungi" id="CBF69740">
        <property type="protein sequence ID" value="CBF69740"/>
        <property type="gene ID" value="ANIA_06306"/>
    </dbReference>
    <dbReference type="GeneID" id="2871095"/>
    <dbReference type="KEGG" id="ani:ANIA_06306"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN6306"/>
    <dbReference type="eggNOG" id="KOG1733">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_141397_0_1_1"/>
    <dbReference type="InParanoid" id="Q5AZH4"/>
    <dbReference type="OMA" id="RCISQCM"/>
    <dbReference type="OrthoDB" id="7813104at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042719">
        <property type="term" value="C:mitochondrial intermembrane space chaperone complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140318">
        <property type="term" value="F:protein transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045039">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.810:FF:000001">
        <property type="entry name" value="mitochondrial import inner membrane translocase subunit TIM13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.810">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim13 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004217">
        <property type="entry name" value="Tim10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035427">
        <property type="entry name" value="Tim10-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02953">
        <property type="entry name" value="zf-Tim10_DDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144122">
        <property type="entry name" value="Tim10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0143">Chaperone</keyword>
    <keyword id="KW-1015">Disulfide bond</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword id="KW-0653">Protein transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0811">Translocation</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000228075" description="Mitochondrial import inner membrane translocase subunit tim13">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Twin CX3C motif">
        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="56"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="108" mass="11313" checksum="8BD93162C2A7052A" modified="2005-04-26" version="1">MALFGSSAPAAAAPANSAEDVQQTKANLIAQLQQEMAMANAKKLISKVNQNCFENCITAPGSSLSASESTCLSSCMEKYIQFWNAASKAYIARATTQTVAANAMATEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="124" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B1P6</accession>
    <accession>C8VG78</accession>
    <name>Q5B1P6_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Hypothetical D-isomer specific 2-hydroxyacid dehydrogenase (Eurofung)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ANIA_05534</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="8">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF81721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_663138.1">
        <property type="nucleotide sequence ID" value="XM_658046.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B1P6"/>
    <dbReference type="FunCoup" id="Q5B1P6">
        <property type="interactions" value="452"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5B1P6"/>
    <dbReference type="GeneID" id="2871826"/>
    <dbReference type="KEGG" id="ani:ANIA_05534"/>
    <dbReference type="eggNOG" id="KOG0069">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019796_1_2_1"/>
    <dbReference type="InParanoid" id="Q5B1P6"/>
    <dbReference type="OMA" id="PHIAWAY"/>
    <dbReference type="OrthoDB" id="9991913at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030267">
        <property type="term" value="F:glyoxylate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016618">
        <property type="term" value="F:hydroxypyruvate reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12168">
        <property type="entry name" value="Mand_dh_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000282">
        <property type="entry name" value="Glyoxylate reductase protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050223">
        <property type="entry name" value="D-isomer_2-hydroxyacid_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996">
        <property type="entry name" value="2-HYDROXYACID DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996:SF269">
        <property type="entry name" value="HYPOTHETICAL D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00670">
        <property type="entry name" value="D_2_HYDROXYACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="5">
        <location>
            <begin position="53"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="6">
        <location>
            <begin position="128"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBF81721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="339" mass="36721" checksum="FC15E94AFE6DD3EE" modified="2005-04-26" version="1">MDTPTRPSISPGPATNPLSAHSTWNSLSSLADLVTPKATNRADFIAECKSGALDGVVVAYRTFDSVSITGLFDEELVNALPSSLVYLAHCGAGYDQISTQACTARNPPLRVSNVPTAVDDATADVNMFLIIGALRNFNAGMHALRQGHWRGLTPPRLGHDPENKVLGILGMGGIGRNLKRKAESFGMKVIYHNRRELSAELAGGAKYVSFEELLKQSDVISLNLPLNKNTRHIISTEQFNQMKDGVVIVNTARGAVMDEDALVKALDNGKVYSAGLDVFEDEPKIHPGLVENPNVLLVPHMGTWTVETQTAMEEWAIENVRMALETGKLKTPVPEQADL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="102" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B1Q0</accession>
    <accession>C8VG82</accession>
    <name>Q5B1Q0_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Splicing factor 3a subunit 2, putative (AFU_orthologue AFUA_4G11880)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">ANIA_05530</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="12">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SF3A2 family.</text>
    </comment>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF81728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_663134.1">
        <property type="nucleotide sequence ID" value="XM_658042.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B1Q0"/>
    <dbReference type="FunCoup" id="Q5B1Q0">
        <property type="interactions" value="396"/>
    </dbReference>
    <dbReference type="STRING" id="227321.Q5B1Q0"/>
    <dbReference type="GeneID" id="2871823"/>
    <dbReference type="KEGG" id="ani:ANIA_05530"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN5530"/>
    <dbReference type="eggNOG" id="KOG0227">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050757_1_0_1"/>
    <dbReference type="InParanoid" id="Q5B1Q0"/>
    <dbReference type="OMA" id="EFWIQIM"/>
    <dbReference type="OrthoDB" id="10250970at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.2690:FF:000002">
        <property type="entry name" value="Splicing factor 3a subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000690">
        <property type="entry name" value="Matrin/U1-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052092">
        <property type="entry name" value="SF3A2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031781">
        <property type="entry name" value="SF3A2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23205">
        <property type="entry name" value="SPLICING FACTOR 3A SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23205:SF0">
        <property type="entry name" value="SPLICING FACTOR 3A SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16835">
        <property type="entry name" value="SF3A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01050">
        <property type="entry name" value="CactinC_cactus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50171">
        <property type="entry name" value="ZF_MATRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Matrin-type" evidence="10">
        <location>
            <begin position="54"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="72"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="86"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CBF81728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="237" mass="27235" checksum="6CD230190D6CF2CA" modified="2005-04-26" version="1">MDYQNRAGSKFGGGGVASHSATNADRRERLRKLALETIDLDKDPYFFKNHVGSFECRLCLTVHQNDGSYLAHTQGRKHQTNLARRAAREQREGKNADPASLPGAMGVQVRKQTIKIGRPGYKITKIRDPLTRQFGLLFQLQYQEITPGVKPRVRFMSAFEQKVEEPPDKNFQYLVIAAEPYQTCGFKLQAREIDRREGRYWTWFDEDSKEFWVQIMFKTEREERFSGVPGLAPMGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2025-10-08" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B1Z3</accession>
    <accession>C8VGI3</accession>
    <name>Q5B1Z3_EMENI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Subtelomeric hrmA-associated cluster protein AFUB-079030/YDR124W-like helical bundle domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ANIA_05437</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="4">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF81911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_663041.1">
        <property type="nucleotide sequence ID" value="XM_657949.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B1Z3"/>
    <dbReference type="STRING" id="227321.Q5B1Z3"/>
    <dbReference type="GeneID" id="2871727"/>
    <dbReference type="KEGG" id="ani:ANIA_05437"/>
    <dbReference type="eggNOG" id="ENOG502S0ES">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045839_0_0_1"/>
    <dbReference type="InParanoid" id="Q5B1Z3"/>
    <dbReference type="OMA" id="CHQKTML"/>
    <dbReference type="OrthoDB" id="5338458at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047092">
        <property type="entry name" value="AFUB_07903/YDR124W-like_hel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021264">
        <property type="entry name" value="AFUB_079030/YDR124W-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36102">
        <property type="entry name" value="CHROMOSOME 10, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36102:SF1">
        <property type="entry name" value="YDR124W-LIKE HELICAL BUNDLE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11001">
        <property type="entry name" value="AFUB_07903_YDR124W_hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Subtelomeric hrmA-associated cluster protein AFUB-079030/YDR124W-like helical bundle" evidence="2">
        <location>
            <begin position="131"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="293"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="425"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="70"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="317"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBF81911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="467" mass="52169" checksum="D9715E084B5D4E87" modified="2005-04-26" version="1">MPGCPDSTNRALDSLESQHFALLYIDESGKLRFEASPSIANDAHAILSPEVTHSFLKAVAGSENGARAGSESAAEFRSGRSSSSPDSPVSSFSPRSNTSLPLDGSRKRKRASHEYVLPMSITSYPKTMLPVGNKRILRSYYEKAFECLQQTNCRILAKAYIKLVEPRKQVTYPYNGHKVVAGVPQQFDPEETRPLWWPTGVTHREPDHLRKPERIRLLIHILCELRESHAICVEKLREADQAIRRQISPVERLQVLDEIYRVRGEEERYLDGRSDSRAVVYVSRVHLPEIADAQTSLHPSNDSTALPDGYREDVPDLVHTSVPPSSSLSTSYSLPKRELDTTSNSITSISIPTSNPTVSTTWEAFHPTIPVSATLPPIHSSMQQDGTDHTKMPYALSYPTSPYGYHQPAPALEMQPFAMGYTNINPHLPPQPSQQNDAHHGHPQTHASMSMMRTDTGFGHHPYYFNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-26" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B2B5</accession>
    <accession>C8VGW2</accession>
    <name>Q5B2B5_EMENI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ANIA_05315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2008.12.003"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain evidence="3">FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="BN001305">
        <property type="protein sequence ID" value="CBF82114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_662919.1">
        <property type="nucleotide sequence ID" value="XM_657827.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5B2B5"/>
    <dbReference type="GeneID" id="2871609"/>
    <dbReference type="KEGG" id="ani:ANIA_05315"/>
    <dbReference type="VEuPathDB" id="FungiDB:AN5315"/>
    <dbReference type="eggNOG" id="ENOG502RYID">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009663_0_0_1"/>
    <dbReference type="InParanoid" id="Q5B2B5"/>
    <dbReference type="OMA" id="DANVRYK"/>
    <dbReference type="OrthoDB" id="3034003at2759"/>
    <dbReference type="Proteomes" id="UP000000560">
        <property type="component" value="Chromosome V"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="699"/>
            <end position="722"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBF82114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000560"/>
        </source>
    </evidence>
    <sequence length="839" mass="90597" checksum="A7583CB9CDDB8E91" modified="2005-04-26" version="1">MELTVAEVSGLIAAGNFVLQILIPLAIPWALSAFLSQENSVITWTILARFFHSSLWPSILGISSTETAGVPWRIYLTSWGQVGLLFLLSVAAICSPLGLYSSIEPASSATEKQFSYIADRSAFRYGTPLRSEGPFTRFCGTESPCPGTTITQTCATRGLSEVCNDTVYESRIPEDLASVFKDGAAAVGPTVASIFDMQYRMYRNSTDQNSELGWYTKPDYRTMSVQILEDKIKLVEGLITDLQDGGIGFRNHTAPKATLKYGASWTEDILFIEPETECVPLNLSIHAITPPSNFNGRFLENFSLVDDGGFADLSRTAPPGSTATAIEQGELDLKDRAYRAAWLNNHYTMVFLNITDGDSQTQTRVDSVHGQRIDLGDGKNNNFSITFSAIQTNLNYGAYLNFTATQNRTFNPHNVTALDFRTASTICGGTTNSSPSNVNSTLVACGLVLGAATRTDGGDNRILDPGTPWTIPLYSCATAIKALVKTVEFQYNGTGFDALKVSSFKPKEYKTPASLPTWGVEDLPEHDIDTAPPMWGLLSPNPNVTALTHYNITTISAASIHLPGYMTPEYPLLRGLNSVPLGSGQNLPGVDFYNQALMTAYTVGAQGFENPEADYSGGHSLALYAKWQGLSKTVDGAAKIIDLVWTDVATNAVVGTAGWGLTASPSSAADGDQSSKSESKNVNVPVFVYGSHIRYRIPWAIPAFVTLGITAMLLALLMTMLVTRRTGFERLRSILESTTLGRVLAPLIPAPDHGHGLGEGADVEITGPGDWVRMVGRRKVLITPEVVSVNGTVLEDKMESIQMSAGQKQQFQPGPVADVDADANADVISPLYPDKVYDS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-04-29" modified="2025-04-09" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>Q5B2V2</accession>
    <accession>C8VEZ0</accession>
    <name>CHZ1_EMENI</name>
    <protein>
        <recommendedName>
            <fullName>Histone H2A.Z-specific chaperone chz1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">chz1</name>
        <name type="ORF">AN5128</name>
    </gene>
    <organism>
        <name type="scientific">Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)</name>
        <name type="synonym">Aspergillus nidulans</name>
        <dbReference type="NCBI Taxonomy" id="227321"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Nidulantes</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2005" name="Nature" volume="438" first="1105" last="1115">
            <title>Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.</title>
            <authorList>
                <person name="Galagan J.E."/>
                <person name="Calvo S.E."/>
                <person name="Cuomo C."/>
                <person name="Ma L.J."/>
                <person name="Wortman J.R."/>
                <person name="Batzoglou S."/>
                <person name="Lee S.I."/>
                <person name="Basturkmen M."/>
                <person name="Spevak C.C."/>
                <person name="Clutterbuck J."/>
                <person name="Kapitonov V."/>
                <person name="Jurka J."/>
                <person name="Scazzocchio C."/>
                <person name="Farman M."/>
                <person name="Butler J."/>
                <person name="Purcell S."/>
                <person name="Harris S."/>
                <person name="Braus G.H."/>
                <person name="Draht O."/>
                <person name="Busch S."/>
                <person name="D'Enfert C."/>
                <person name="Bouchier C."/>
                <person name="Goldman G.H."/>
                <person name="Bell-Pedersen D."/>
                <person name="Griffiths-Jones S."/>
                <person name="Doonan J.H."/>
                <person name="Yu J."/>
                <person name="Vienken K."/>
                <person name="Pain A."/>
                <person name="Freitag M."/>
                <person name="Selker E.U."/>
                <person name="Archer D.B."/>
                <person name="Penalva M.A."/>
                <person name="Oakley B.R."/>
                <person name="Momany M."/>
                <person name="Tanaka T."/>
                <person name="Kumagai T."/>
                <person name="Asai K."/>
                <person name="Machida M."/>
                <person name="Nierman W.C."/>
                <person name="Denning D.W."/>
                <person name="Caddick M."/>
                <person name="Hynes M."/>
                <person name="Paoletti M."/>
                <person name="Fischer R."/>
                <person name="Miller B."/>
                <person name="Dyer P."/>
                <person name="Sachs M.S."/>
                <person name="Osmani S.A."/>
                <person name="Birren B.W."/>
            </authorList>
            <dbReference type="PubMed" id="16372000"/>
            <dbReference type="DOI" id="10.1038/nature04341"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="Fungal Genet. Biol." volume="46" first="S2" last="13">
            <title>The 2008 update of the Aspergillus nidulans genome annotation: a community effort.</title>
            <authorList>
                <person name="Wortman J.R."/>
                <person name="Gilsenan J.M."/>
                <person name="Joardar V."/>
                <person name="Deegan J."/>
                <person name="Clutterbuck J."/>
                <person name="Andersen M.R."/>
                <person name="Archer D."/>
                <person name="Bencina M."/>
                <person name="Braus G."/>
                <person name="Coutinho P."/>
                <person name="von Dohren H."/>
                <person name="Doonan J."/>
                <person name="Driessen A.J."/>
                <person name="Durek P."/>
                <person name="Espeso E."/>
                <person name="Fekete E."/>
                <person name="Flipphi M."/>
                <person name="Estrada C.G."/>
                <person name="Geysens S."/>
                <person name="Goldman G."/>
                <person name="de Groot P.W."/>
                <person name="Hansen K."/>
                <person name="Harris S.D."/>
                <person name="Heinekamp T."/>
                <person name="Helmstaedt K."/>
                <person name="Henrissat B."/>
                <person name="Hofmann G."/>
                <person name="Homan T."/>
                <person name="Horio T."/>
                <person name="Horiuchi H."/>
                <person name="James S."/>
                <person name="Jones M."/>
                <person name="Karaffa L."/>
                <person name="Karanyi Z."/>
                <person name="Kato M."/>
                <person name="Keller N."/>
                <person name="Kelly D.E."/>
                <person name="Kiel J.A."/>
                <person name="Kim J.M."/>
                <person name="van der Klei I.J."/>
                <person name="Klis F.M."/>
                <person name="Kovalchuk A."/>
                <person name="Krasevec N."/>
                <person name="Kubicek C.P."/>
                <person name="Liu B."/>
                <person name="Maccabe A."/>
                <person name="Meyer V."/>
                <person name="Mirabito P."/>
                <person name="Miskei M."/>
                <person name="Mos M."/>
                <person name="Mullins J."/>
                <person name="Nelson D.R."/>
                <person name="Nielsen J."/>
                <person name="Oakley B.R."/>
                <person name="Osmani S.A."/>
                <person name="Pakula T."/>
                <person name="Paszewski A."/>
                <person name="Paulsen I."/>
                <person name="Pilsyk S."/>
                <person name="Pocsi I."/>
                <person name="Punt P.J."/>
                <person name="Ram A.F."/>
                <person name="Ren Q."/>
                <person name="Robellet X."/>
                <person name="Robson G."/>
                <person name="Seiboth B."/>
                <person name="van Solingen P."/>
                <person name="Specht T."/>
                <person name="Sun J."/>
                <person name="Taheri-Talesh N."/>
                <person name="Takeshita N."/>
                <person name="Ussery D."/>
                <person name="vanKuyk P.A."/>
                <person name="Visser H."/>
                <person name="van de Vondervoort P.J."/>
                <person name="de Vries R.P."/>
                <person name="Walton J."/>
                <person name="Xiang X."/>
                <person name="Xiong Y."/>
                <person name="Zeng A.P."/>
                <person name="Brandt B.W."/>
                <person name="Cornell M.J."/>
                <person name="van den Hondel C.A."/>
                <person name="Visser J."/>
                <person name="Oliver S.G."/>
                <person name="Turner G."/>
            </authorList>
            <dbReference type="PubMed" id="19146970"/>
            <dbReference type="DOI" id="
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